locus-tag class description AOD63_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AOD63_00015 ENOG410848D S4 domain protein YaaA AOD63_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOD63_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AOD63_00100 ENOG4105ZMH deoxynucleoside kinase AOD63_00110 ENOG4105GTG Isochorismatase AOD63_00120 ENOG4108Z6B deaminase AOD63_00125 ENOG4105C6E dna polymerase iii AOD63_00145 ENOG41067KS pro-sigma K processing AOD63_00180 ENOG4105CXN decarboxylase AOD63_00190 ENOG4105FA2 dna polymerase iii AOD63_00195 ENOG4105MA4 psp1 domain protein AOD63_00205 ENOG41060K3 Methyltransferase AOD63_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AOD63_00220 ENOG4105KRN Transcriptional regulator, abrb family AOD63_00230 ENOG4105F8V Hydrolase, tatD family AOD63_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AOD63_00245 ENOG4105XFA sporulation peptidase YabG AOD63_00250 ENOG4105W42 Veg protein AOD63_00265 ENOG4105DFT pur operon repressor AOD63_00270 ENOG4105KME endoribonuclease L-psp AOD63_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AOD63_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AOD63_00300 ENOG4108JA2 transcriptioN-repair coupling factor AOD63_00305 ENOG4108M14 stage v sporulation protein t AOD63_00315 ENOG4108IY2 MazG family AOD63_00320 ENOG41082I2 s4 domain protein AOD63_00325 ENOG4105VYY sporulation protein yabp AOD63_00340 ENOG41060GV RNA binding s1 domain protein AOD63_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AOD63_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase AOD63_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AOD63_00385 ENOG4105C6T cysteine synthase AOD63_00390 ENOG4105CRQ synthase (Component I) AOD63_00395 ENOG4105DDQ anthranilate synthase AOD63_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AOD63_00405 ENOG4105EEI dihydropteroate synthase AOD63_00410 ENOG4105KRF dihydroneopterin aldolase AOD63_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AOD63_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AOD63_00455 ENOG4108Z0C Uvrb UvrC protein AOD63_00470 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AOD63_00480 ENOG4105CTP PilT protein domain protein AOD63_00500 ENOG4105D7W serine acetyltransferase AOD63_00515 ENOG4105C2N RNA methyltransferase TrmH family group 3 AOD63_00520 ENOG4105M0M Tetracycline resistance protein AOD63_00525 ENOG4105QIV RNA polymerase AOD63_00540 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AOD63_00565 ENOG4107Y49 methyltransferase AOD63_00575 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AOD63_00580 ENOG4105XPM ribosomal protein AOD63_00685 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AOD63_00710 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AOD63_00720 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AOD63_00730 ENOG41067V7 50S ribosomal protein L36 AOD63_00760 ENOG4108JJB ABC transporter AOD63_00765 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AOD63_00770 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AOD63_00795 ENOG4105D1F ATP-binding protein AOD63_00810 ENOG4108NMV polysaccharide deacetylase AOD63_00895 ENOG4105C8B TIGR00159 family AOD63_00900 ENOG4107U5W ybbr family AOD63_00915 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AOD63_00920 ENOG4108VQT Alpha beta hydrolase fold protein AOD63_00940 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AOD63_00945 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AOD63_00980 ENOG4108PSK reductase AOD63_00985 ENOG4108UMI ABC transporter, permease AOD63_00990 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOD63_00995 ENOG4105D01 (LipO)protein AOD63_01000 ENOG4105EE1 crotonyl-CoA reductase AOD63_01010 ENOG4105IQ5 FAD linked oxidase domain protein AOD63_01025 ENOG4105C2C drug resistance transporter, Bcr CflA AOD63_01040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOD63_01045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD63_01050 ENOG4105C3U ABC transporter AOD63_01055 ENOG4108JQ7 (ABC) transporter AOD63_01085 ENOG4108J59 Extracellular solute-binding protein, family 5 AOD63_01090 ENOG4108J59 Extracellular solute-binding protein, family 5 AOD63_01100 ENOG4105II7 pyrroline-5-carboxylate reductase AOD63_01110 ENOG4107XDY Nicotinamide Mononucleotide Transporter AOD63_01120 ENOG4105E0C molybdate abc transporter AOD63_01125 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOD63_01130 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOD63_01135 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AOD63_01150 ENOG4105EGI Transcriptional regulator AOD63_01165 ENOG4105F6E Acyl-transferase AOD63_01185 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AOD63_01200 ENOG4108RE7 deoxyribonuclease AOD63_01205 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AOD63_01230 ENOG4105C5H ABC transporter AOD63_01240 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AOD63_01250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD63_01255 ENOG4105C3U ABC transporter AOD63_01260 ENOG4108JQ7 (ABC) transporter AOD63_01285 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AOD63_01290 ENOG4105ERH Fumarylacetoacetate hydrolase AOD63_01300 ENOG4108SC4 )-transporter AOD63_01305 ENOG4105CPF Cell wall formation (By similarity) AOD63_01310 ENOG4105CPF Cell wall formation (By similarity) AOD63_01315 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AOD63_01330 ENOG4107ZXI Rhomboid family AOD63_01340 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AOD63_01345 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AOD63_01355 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AOD63_01455 ENOG4105K8N protein family UPF0079, ATPase AOD63_01460 ENOG41072GX Peptidase M22 Glycoprotease AOD63_01465 ENOG410801F ribosomal-protein-alanine acetyltransferase AOD63_01470 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AOD63_01475 ENOG4105C5H ABC transporter AOD63_01490 ENOG4108TYN CAAX amino terminal protease family protein AOD63_01510 ENOG4105C7N Xanthine uracil vitamin C permease AOD63_01520 ENOG4105BZU Histidine kinase AOD63_01550 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOD63_01590 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOD63_01610 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD63_01630 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AOD63_01635 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AOD63_01640 ENOG4105C83 adenylosuccinate lyase AOD63_01650 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AOD63_01675 ENOG4108V3E phosphoribosylglycinamide formyltransferase AOD63_01685 ENOG4105C12 Phosphoribosylglycinamide synthetase AOD63_01710 ENOG4105C4R Atp-dependent dna helicase AOD63_01740 ENOG4108W2Y isochorismatase AOD63_01745 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOD63_01750 ENOG4108UMI ABC transporter, permease AOD63_01755 ENOG4105D01 (LipO)protein AOD63_01775 ENOG410834F Transcriptional regulator AOD63_01800 ENOG4105CBD Diacylglycerol kinase AOD63_01805 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AOD63_01810 ENOG4108JPW Aminotransferase AOD63_01820 ENOG4105C26 Dehydrogenase AOD63_01825 ENOG4105KPY Small multidrug resistance protein AOD63_01845 ENOG4105D9N nucleoside AOD63_01850 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AOD63_01865 ENOG4108W15 Protein of unknown function (DUF1456) AOD63_01880 ENOG4105DTQ mandelate racemase muconate lactonizing AOD63_01890 ENOG4105DFD Na H antiporter AOD63_01910 ENOG4105D3R alkyl hydroperoxide reductase AOD63_01915 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AOD63_01925 ENOG4107W7X Aldolase AOD63_01930 ENOG4105EHG Permease protein AOD63_01935 ENOG4105DQ5 transport system permease protein AOD63_01940 ENOG4108V5C ABC transporter AOD63_01965 ENOG4106UIA AOD63_01970 ENOG4106UIA AOD63_01995 ENOG4105BZU Histidine kinase AOD63_02015 ENOG410756H nucleotidyltransferase AOD63_02020 ENOG4105D2S major facilitator superfamily AOD63_02035 ENOG4105E5Q amino acid AbC transporter AOD63_02040 ENOG4105EAB amino acid AbC transporter AOD63_02055 ENOG4105C8Q Methyl-accepting chemotaxis AOD63_02060 ENOG4105C8Q Methyl-accepting chemotaxis AOD63_02070 ENOG4105CI1 PTS System AOD63_02100 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AOD63_02115 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AOD63_02130 ENOG4105C5H ABC transporter AOD63_02155 ENOG41062JF Transcriptional regulator AOD63_02175 ENOG4105DEU major facilitator superfamily AOD63_02190 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) AOD63_02205 ENOG4108N0M stress protein AOD63_02210 ENOG4106FN3 tellurium resistance protein AOD63_02215 ENOG4106FN3 tellurium resistance protein AOD63_02220 ENOG4107TS3 membrane protein, TerC AOD63_02225 ENOG4108TTB tellurium resistance protein AOD63_02245 ENOG4105KJF protein tyrosine phosphatase AOD63_02255 ENOG4107U9T Pfam:Ribonuclease_BN AOD63_02260 ENOG4105C59 p-type ATPase AOD63_02265 ENOG4108IPJ Membrane AOD63_02285 ENOG4107ZTW SNARE associated Golgi AOD63_02300 ENOG410606W general stress protein AOD63_02305 ENOG4105UPD Calcium Proton AOD63_02345 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AOD63_02350 ENOG4105VTR Integrase AOD63_02355 ENOG4108IMY Transcriptional regulator AOD63_02630 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AOD63_02640 ENOG4108JUB Transcriptional regulator AOD63_02650 ENOG4108IQI permease AOD63_02685 ENOG4105CSV Glutaminase AOD63_02695 ENOG4108A04 Beta-lactamase AOD63_02710 ENOG4105CKK Glycosyl transferase, family 2 AOD63_02720 ENOG4107QQG Dehydrogenase AOD63_02725 ENOG4105C3I Nad-dependent epimerase dehydratase AOD63_02745 ENOG4105F1A Pyruvate formate-lyase AOD63_02765 ENOG4105CI2 imidazolone-5-propionate hydrolase AOD63_02770 ENOG4105ECP epimerase AOD63_02800 ENOG41067AE Membrane-bound metal-dependent hydrolase AOD63_02805 ENOG4105CEN a g-specific adenine glycosylase AOD63_02810 ENOG4106BXE AOD63_02830 ENOG4105BZ1 (ABC) transporter AOD63_02835 ENOG4107NBY Membrane AOD63_02840 ENOG4105CBC glutamate synthase AOD63_02850 ENOG4108IUW ABC transporter AOD63_02870 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AOD63_02875 ENOG4105G5W regulator Fur family AOD63_02990 ENOG4108JQC penicillin-binding protein 1A AOD63_02995 ENOG4107ZQN disulfide bond AOD63_03005 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AOD63_03015 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AOD63_03020 ENOG4105BZU Histidine kinase AOD63_03030 ENOG4105CYN Serine protein kinase AOD63_03055 ENOG4105C94 Transporter AOD63_03070 ENOG4105DZ6 Band 7 protein AOD63_03080 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AOD63_03090 ENOG4105D4T Citrate transporter AOD63_03110 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AOD63_03115 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOD63_03120 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AOD63_03125 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AOD63_03130 ENOG4105BZ7 extracellular solute-binding protein family 1 AOD63_03135 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AOD63_03140 ENOG4108STX response regulator AOD63_03145 ENOG4105US7 Histidine kinase AOD63_03170 ENOG4108MRH transcriptional regulatory protein AOD63_03180 ENOG4105C6K Malic enzyme AOD63_03190 ENOG4108UZ3 Transporter AOD63_03195 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AOD63_03205 ENOG4105BZU Histidine kinase AOD63_03210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD63_03220 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AOD63_03225 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AOD63_03230 ENOG4108JB9 formate dehydrogenase AOD63_03250 ENOG4105CUB amino acid AOD63_03260 ENOG4105C59 p-type ATPase AOD63_03265 ENOG4105DAP Nicotinate phosphoribosyltransferase AOD63_03295 ENOG41073R8 VanW family AOD63_03300 ENOG4108KGH TRANSCRIPTIONal AOD63_03305 ENOG4105D9N nucleoside AOD63_03310 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AOD63_03315 ENOG4105C37 (CBS) domain AOD63_03320 ENOG4108IJ0 Aspartate ammonia-lyase AOD63_03325 ENOG4105DAA L-lactate AOD63_03340 ENOG4105DUX Transporter AOD63_03345 ENOG4108MES Periplasmic binding protein AOD63_03350 ENOG4105DQ5 transport system permease protein AOD63_03355 ENOG4108IHU transport system permease protein AOD63_03360 ENOG4105E0A ABC, transporter AOD63_03365 ENOG4105DMQ Methyltransferase AOD63_03385 ENOG4107T89 von Willebrand factor, type A AOD63_03390 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AOD63_03395 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOD63_03410 ENOG4105BZU Histidine kinase AOD63_03415 ENOG4105D5Q Arginine ornithine antiporter AOD63_03420 ENOG4107414 GntR family transcriptional regulator AOD63_03425 ENOG4105C5Y PTS System AOD63_03430 ENOG4105CG3 alpha amylase, catalytic region AOD63_03445 ENOG4105E1K spore germination protein AOD63_03455 ENOG4105CRN Aminoglycoside phosphotransferase AOD63_03460 ENOG4105BZG amino acid carrier protein AOD63_03465 ENOG4105CDA abc transporter atp-binding protein AOD63_03470 ENOG4105CT1 (ABC) transporter AOD63_03475 ENOG4105EAD ABC transporter AOD63_03480 ENOG4105DRP amino acid AbC transporter AOD63_03485 ENOG4108IQI permease AOD63_03510 ENOG4105D29 Helix-turn-helix type 11 domain protein AOD63_03515 ENOG4105NAE bifunctional deaminase-reductase domain protein AOD63_03520 ENOG4105BZU Histidine kinase AOD63_03535 ENOG4105CHH sulfate transporter AOD63_03540 ENOG41068KF Universal stress protein AOD63_03550 ENOG4105DEF Extracellular solute-binding protein, family 5 AOD63_03560 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOD63_03565 ENOG4108JQ7 (ABC) transporter AOD63_03570 ENOG4105C3U ABC transporter AOD63_03575 ENOG4105CXY transporter AOD63_03580 ENOG41067TZ transcriptional regulator, MarR family AOD63_03585 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD63_03590 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD63_03595 ENOG4105ETE Transcriptional regulator (LacI family AOD63_03600 ENOG4108RVA ribokinase AOD63_03610 ENOG4105C2J ABC transporter AOD63_03615 ENOG4105CNN ABC, transporter AOD63_03620 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AOD63_03625 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AOD63_03685 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOD63_03690 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AOD63_03695 ENOG41069ER domain protein AOD63_03700 ENOG4105VZ8 Transcriptional regulator AOD63_03705 ENOG4107D63 AOD63_03715 ENOG4105DUX Transporter AOD63_03735 ENOG4105C85 amino acid AOD63_03740 ENOG4105C7N Xanthine uracil vitamin C permease AOD63_03780 ENOG4105BZ9 Cytochrome C oxidase, subunit I AOD63_03785 ENOG4105E2S oxidase) subunit II AOD63_03790 ENOG4108IQI permease AOD63_03805 ENOG4106CAD Protein of unknown function (DUF3311) AOD63_03810 ENOG4105E1V na solute symporter AOD63_03825 ENOG4108NHD germination protein AOD63_03835 ENOG4105CE1 Ferrous iron transport protein b AOD63_03840 ENOG4105CE1 Ferrous iron transport protein b AOD63_03845 ENOG4105CE1 Ferrous iron transport protein b AOD63_03850 ENOG4105CVA phosphate AOD63_03855 ENOG4105C8U phosphate abc transporter AOD63_03860 ENOG4105E2Z phosphate ABC transporter (Permease AOD63_03985 ENOG41080XQ Signal transduction protein with cbs domains AOD63_04010 ENOG4105ETU transcriptional activator (TenA AOD63_04020 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AOD63_04030 ENOG4108VEU Thiamine monophosphate synthase AOD63_04035 ENOG41080HI glycine oxidase AOD63_04050 ENOG4105D06 uba thif-type nad fad binding protein AOD63_04055 ENOG4105DWF phosphomethylpyrimidine kinase AOD63_04105 ENOG4108INS Transcriptional regulator AOD63_04120 ENOG4105C7N Xanthine uracil vitamin C permease AOD63_04150 ENOG4105C5Y PTS System AOD63_04210 ENOG4107Y03 Nitroreductase AOD63_04215 ENOG4105ED1 spovr family AOD63_04240 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AOD63_04245 ENOG4105XTG Pfam:DUF156 AOD63_04250 ENOG4105VFE sira family AOD63_04255 ENOG4107TPS domain protein AOD63_04260 ENOG4105VFE sira family AOD63_04265 ENOG41085GJ domain protein AOD63_04275 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AOD63_04280 ENOG41087NI Sulfite exporter TauE/SafE AOD63_04290 ENOG4108KGH TRANSCRIPTIONal AOD63_04315 ENOG4105EMD TRANSCRIPTIONal AOD63_04320 ENOG4105VCP PTS System AOD63_04325 ENOG4105VZJ PTS System AOD63_04345 ENOG41069ER domain protein AOD63_04350 ENOG4107RBB ABC transporter, permease AOD63_04355 ENOG4105C19 ABC transporter AOD63_04385 ENOG4105WEF catalase AOD63_04420 ENOG4107T5V SNARE associated Golgi AOD63_04455 ENOG4105CUB amino acid AOD63_04460 ENOG4107RWR Sodium hydrogen exchanger AOD63_04470 ENOG4106KNT transcriptional regulator AOD63_04505 ENOG4108PCN EamA-like transporter family AOD63_04510 ENOG4108YXU transcriptional regulator AsnC family AOD63_04520 ENOG4105KPY Small multidrug resistance protein AOD63_04525 ENOG4105KPY Small multidrug resistance protein AOD63_04550 ENOG4105NF4 modulator of drug activity AOD63_04555 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AOD63_04560 ENOG4105E5W Transporter AOD63_04570 ENOG4107RKG DJ-1/PfpI family AOD63_04575 ENOG4105CH6 catalase AOD63_04585 ENOG4105D5Q Arginine ornithine antiporter AOD63_04590 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AOD63_04600 ENOG4105C26 Dehydrogenase AOD63_04610 ENOG4105BZ1 (ABC) transporter AOD63_04625 ENOG4105DRP amino acid AbC transporter AOD63_04630 ENOG4105CDA abc transporter atp-binding protein AOD63_04645 ENOG410839P AOD63_04680 ENOG4107FQX Alpha-acetolactate decarboxylase AOD63_04710 ENOG4105D4P Coproporphyrinogen iii oxidase AOD63_04725 ENOG4105CHH sulfate transporter AOD63_04765 ENOG4106AKK s-layer domain-containing protein AOD63_04775 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOD63_04780 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOD63_04795 ENOG4105CGU Enoyl-CoA hydratase AOD63_04815 ENOG4105DER m42 family AOD63_04835 ENOG4105CTU Proline racemase AOD63_04880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD63_04890 ENOG4108JQ7 (ABC) transporter AOD63_04920 ENOG4105CSH Transporter AOD63_04930 ENOG4108MRH transcriptional regulatory protein AOD63_04980 ENOG4105CDU Replicative dna helicase AOD63_05020 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD63_05070 ENOG4107P5I polyketide synthase AOD63_05075 ENOG4108IG5 Transcriptional regulator AOD63_05095 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AOD63_05115 ENOG4105CMT Dihydroxyacetone kinase AOD63_05130 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AOD63_05135 ENOG410847I Transcriptional regulator, BadM Rrf2 family AOD63_05160 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AOD63_05225 ENOG4105WN5 stage II sporulation protein AOD63_05235 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD63_05245 ENOG4108MJI response regulator AOD63_05250 ENOG4105BZU Histidine kinase AOD63_05255 ENOG4105BZU Histidine kinase AOD63_05280 ENOG4105K8R UPF0145 protein AOD63_05315 ENOG4107VRP DNA repair exonuclease AOD63_05320 ENOG4106D4I domain protein AOD63_05325 ENOG4105D7V transposase AOD63_05340 ENOG4108IND Tetr family transcriptional regulator AOD63_05345 ENOG4105EQ0 Major Facilitator superfamily AOD63_05365 ENOG4108MUZ hydrolase AOD63_05385 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AOD63_05400 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AOD63_05415 ENOG4105EMN RNA polymerase sigma factor AOD63_05440 ENOG4105C57 major facilitator superfamily AOD63_05445 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD63_05455 ENOG4105EEM helicase AOD63_05460 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOD63_05490 ENOG4105K59 histidine triad (HIT) protein AOD63_05520 ENOG410905X membrane-flanked domain protein AOD63_05530 ENOG4105CKV Membrane AOD63_05570 ENOG410905X membrane-flanked domain protein AOD63_05575 ENOG4105CKV Membrane AOD63_05580 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AOD63_05585 ENOG4105BZ4 penicillin-binding protein AOD63_05590 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AOD63_05600 ENOG4105C1Q protoporphyrinogen oxidase AOD63_05625 ENOG4105NA0 Transcriptional regulator AOD63_05640 ENOG4105ECB domain protein AOD63_05670 ENOG4106AXD AOD63_05675 ENOG4108RQ5 Beta-lactamase domain-containing protein AOD63_05680 ENOG4105DF9 Lipoate-protein, ligase AOD63_05690 ENOG4105CEY Amp-dependent synthetase and ligase AOD63_05720 ENOG4105CNA YD repeat protein AOD63_05755 ENOG4105ENX hydrolase AOD63_05765 ENOG4107RN3 metallophosphoesterase AOD63_05770 ENOG4107TVP HD domain protein AOD63_05780 ENOG4108AEY RNA polymerase sigma factor AOD63_05785 ENOG41086D8 Transcriptional regulator AOD63_05805 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD63_05830 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AOD63_05835 ENOG4105C8Q Methyl-accepting chemotaxis AOD63_05855 ENOG4105ZU5 s-layer protein AOD63_05860 ENOG4107QP3 malate synthase g AOD63_05875 ENOG4105VEQ Cold shock protein AOD63_05890 ENOG4105XVF Competence transcription factor AOD63_05905 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AOD63_05910 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AOD63_05955 ENOG4105ERH Fumarylacetoacetate hydrolase AOD63_05980 ENOG4105CAQ asparagine synthetase AOD63_05985 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AOD63_05990 ENOG4105CH6 catalase AOD63_05995 ENOG4105BZU Histidine kinase AOD63_06020 ENOG4105QNR S1 RNA binding domain protein AOD63_06030 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOD63_06040 ENOG4107AYK membrAne AOD63_06045 ENOG41073B9 AOD63_06055 ENOG4108KP7 hydrolase AOD63_06070 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AOD63_06095 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOD63_06100 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AOD63_06115 ENOG4105C31 Tryptophanyl-tRNA synthetase AOD63_06130 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOD63_06135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD63_06145 ENOG4108JQ7 (ABC) transporter AOD63_06150 ENOG4105UQX Mate efflux family protein AOD63_06175 ENOG4108ZCF integral membrane protein AOD63_06185 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOD63_06195 ENOG4105DPN Oligoendopeptidase f AOD63_06210 ENOG4108Z18 K06886 hemoglobin AOD63_06215 ENOG4105MIX Adenylate cyclase AOD63_06230 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AOD63_06235 ENOG4105EMS pseudouridine synthase AOD63_06255 ENOG4105K64 Glycosyl transferase, family 2 AOD63_06275 ENOG4107TVC Glycosyl transferase, family 2 AOD63_06295 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AOD63_06300 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AOD63_06310 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AOD63_06360 ENOG4108WVJ 2'-5' rna ligase AOD63_06385 ENOG4105CK7 Sodium proline symporter AOD63_06395 ENOG4105CRQ synthase (Component I) AOD63_06400 ENOG4105DDQ anthranilate synthase AOD63_06490 ENOG4105C7S Dehydrogenase AOD63_06500 ENOG4105VZ8 Transcriptional regulator AOD63_06560 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AOD63_06570 ENOG4105DZ1 carboxypeptidase AOD63_06575 ENOG4105VFR signal peptidase AOD63_06610 ENOG4105C26 Dehydrogenase AOD63_06615 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOD63_06620 ENOG4105F38 ABC transporter, permease AOD63_06625 ENOG4105D38 putrescine abc transporter AOD63_06630 ENOG4107RUE extracellular solute-binding protein family 1 AOD63_06640 ENOG4105EYF MMPL domain protein AOD63_06650 ENOG4108YBP pseudouridine synthase AOD63_06660 ENOG4105K4I Scp-like extracellular AOD63_06665 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AOD63_06670 ENOG4105CQB FAD linked oxidase domain protein AOD63_06685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD63_06690 ENOG4105BZU Histidine kinase AOD63_06695 ENOG4105JXH GntR family transcriptional regulator AOD63_06715 ENOG4106A3R peptidase AOD63_06725 ENOG4108QTI )-transporter AOD63_06730 ENOG4107TS3 membrane protein, TerC AOD63_06735 ENOG4105CZN Potassium uptake protein AOD63_06740 ENOG410681C small acid-soluble spore protein AOD63_06745 ENOG4108Z7G MaoC domain protein dehydratase AOD63_06765 ENOG4105CHR reductase AOD63_06775 ENOG4105MWK D-amino acid dehydrogenase, small subunit AOD63_06795 ENOG4105C4Y ABC transporter AOD63_06810 ENOG4107RCV ABC transporter, permease AOD63_06815 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AOD63_06830 ENOG4105E98 transcriptional regulator DeoR family AOD63_06855 ENOG4105PXI polysaccharide deacetylase AOD63_06865 ENOG4105BZU Histidine kinase AOD63_06870 ENOG41090MY MarR family Transcriptional regulator AOD63_06880 ENOG4106DF1 AOD63_06890 ENOG4105BZU Histidine kinase AOD63_06900 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AOD63_06905 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AOD63_06950 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AOD63_06970 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AOD63_06975 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AOD63_06980 ENOG4105CZV ABC transporter AOD63_06990 ENOG4105CJ1 ABC, transporter AOD63_07030 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AOD63_07035 ENOG4105EA8 2-Nitropropane dioxygenase AOD63_07040 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AOD63_07050 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOD63_07075 ENOG4105NQC Flavodoxin AOD63_07110 ENOG4107QMU Mate efflux family protein AOD63_07115 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOD63_07145 ENOG4105CZN Potassium uptake protein AOD63_07150 ENOG41063Y9 AOD63_07155 ENOG4105KBJ sporulation protein ytfj AOD63_07185 ENOG4105CM2 brancheD-chain amino acid aminotransferase AOD63_07190 ENOG4105C7K acetolactate synthase AOD63_07195 ENOG4108ZP8 Acetolactate synthase small subunit AOD63_07200 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AOD63_07210 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AOD63_07235 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AOD63_07270 ENOG4107RVV histidinol phosphate phosphatase, hisj family AOD63_07285 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AOD63_07290 ENOG4105E0M Sulfatase AOD63_07300 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AOD63_07320 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AOD63_07325 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AOD63_07335 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AOD63_07340 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AOD63_07345 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AOD63_07355 ENOG4105C8J )-transporter AOD63_07375 ENOG4105DFD Na H antiporter AOD63_07395 ENOG4105ENE Histidine kinase AOD63_07400 ENOG4105WH1 Two component transcriptional regulator luxr family AOD63_07420 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AOD63_07445 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AOD63_07470 ENOG4105CJ3 phosphate transporter AOD63_07475 ENOG4107GRR phosphate transport regulator AOD63_07480 ENOG4105BZ4 penicillin-binding protein AOD63_07495 ENOG4105BZU Histidine kinase AOD63_07500 ENOG4105I3N Conserved Protein AOD63_07515 ENOG4105BZU Histidine kinase AOD63_07550 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOD63_07555 ENOG4105DZ1 carboxypeptidase AOD63_07560 ENOG4108JIC nucleoside recognition domain protein AOD63_07570 ENOG4105FE9 pseudouridine synthase AOD63_07580 ENOG4107TWT Cytochrome c biogenesis protein AOD63_07585 ENOG4105CRE cytochrome C AOD63_07590 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD63_07595 ENOG4105BZU Histidine kinase AOD63_07600 ENOG4108WBT adenosyltransferase AOD63_07615 ENOG4108SAX Membrane AOD63_07625 ENOG4105T7X AOD63_07630 ENOG4105C9U ATP-dependent DNA helicase RecQ AOD63_07635 ENOG4105I7S Abortive infection protein AOD63_07650 ENOG4107X2D transcriptional regulator, merr family AOD63_07655 ENOG4108S6Z Negative regulator of genetic competence AOD63_07680 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AOD63_07685 ENOG4107RB3 L-asparaginase AOD63_07720 ENOG4105S2F AOD63_07725 ENOG41065D1 AOD63_07755 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AOD63_07770 ENOG4105XXQ heptaprenyl diphosphate synthase component I AOD63_07780 ENOG4105EAH synthase AOD63_07800 ENOG4105CIH Imidazole acetol-phosphate transaminase AOD63_07805 ENOG41068YB TPR repeat-containing protein AOD63_07820 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AOD63_07825 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AOD63_07830 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AOD63_07860 ENOG4108JYZ YitT family AOD63_07865 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AOD63_07880 ENOG4105FJR Lmbe family AOD63_07885 ENOG4105CPK Glycosyl transferase (Group 1 AOD63_07925 ENOG4105DVT helicase AOD63_07930 ENOG4105YAC AOD63_07950 ENOG4105CSM endonuclease III AOD63_07960 ENOG4105BZ4 penicillin-binding protein AOD63_08010 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AOD63_08020 ENOG4105DVT helicase AOD63_08025 ENOG4105CTD carboxy-peptidase AOD63_08040 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AOD63_08050 ENOG4105C2W permease AOD63_08055 ENOG4105DHF Membrane AOD63_08060 ENOG410890F Dynamin family AOD63_08070 ENOG4108W0I acetyltransferase AOD63_08080 ENOG4105KHC sulfurtransferase AOD63_08095 ENOG4106032 Glutathionylspermidine synthase AOD63_08155 ENOG4105CPK Glycosyl transferase (Group 1 AOD63_08170 ENOG4108SZE gCN5-related N-acetyltransferase AOD63_08190 ENOG41081VK Ribonuclease AOD63_08255 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOD63_08265 ENOG4107RWR Sodium hydrogen exchanger AOD63_08270 ENOG4105CN5 Metallo-Beta-Lactamase AOD63_08275 ENOG4108Z5V transcriptional regulator, merr family AOD63_08285 ENOG4105H67 Protein of unknown function (DUF421) AOD63_08290 ENOG41080C8 DUF218 domain AOD63_08345 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AOD63_08355 ENOG4107R0U MotA TolQ exbB proton channel AOD63_08360 ENOG4105ER2 Ompa motb domain protein AOD63_08365 ENOG4107YTP response regulator receiver protein AOD63_08375 ENOG4105DD5 Flagellar motor switch protein AOD63_08390 ENOG4105BZU Histidine kinase AOD63_08410 ENOG4105E1Q flagellar hook-associated protein AOD63_08415 ENOG4105DTJ flagellar hook-associated protein AOD63_08440 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AOD63_08445 ENOG4108ZC9 flagellar basal-body rod protein flgc AOD63_08450 ENOG41075Z6 flagellar hook-basal body complex protein fliE AOD63_08455 ENOG4107U2N Flagellar M-ring protein AOD63_08465 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AOD63_08500 ENOG4105BZE flagellar hook protein, FlgE AOD63_08525 ENOG4105K64 Glycosyl transferase, family 2 AOD63_08555 ENOG4107TVC Glycosyl transferase, family 2 AOD63_08580 ENOG4105I03 Flagellin AOD63_08585 ENOG4105E4C Lytic transglycosylase catalytic AOD63_08600 ENOG4105DD5 Flagellar motor switch protein AOD63_08610 ENOG4105CN7 Flagellar biosynthetic protein FliP AOD63_08615 ENOG4105VS8 Flagellar biosynthetic protein fliq AOD63_08625 ENOG4105D00 flagellar biosynthetic protein flhB AOD63_08630 ENOG4105D7B Flagellar biosynthesis protein flha AOD63_08640 ENOG4105KTQ flagellar basal-body rod protein AOD63_08645 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOD63_08670 ENOG4108RZE Tetr family transcriptional regulator AOD63_08690 ENOG4105KAC Antibiotic biosynthesis monooxygenase AOD63_08715 ENOG4105DUM transcriptional regulator, lysR family AOD63_08720 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOD63_08725 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOD63_08730 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AOD63_08735 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AOD63_08770 ENOG4105CVJ phosphoglycerate mutase AOD63_08800 ENOG4105CAQ asparagine synthetase AOD63_08820 ENOG4105PGM cation diffusion facilitator family transporter AOD63_08830 ENOG4105DRR Transcriptional regulator, GntR family AOD63_08835 ENOG4108UZ3 Transporter AOD63_08840 ENOG4105CKI cobalamin synthesis protein AOD63_08845 ENOG4108PJD permease AOD63_08860 ENOG4105DFD Na H antiporter AOD63_08865 ENOG4105C9Q fumarate hydratase class II AOD63_08895 ENOG4105EC3 peptidase S51, dipeptidase E AOD63_08915 ENOG4107QIV Cytochrome c biogenesis protein AOD63_08950 ENOG4106BRA Membrane AOD63_08985 ENOG4105CJ1 ABC, transporter AOD63_09005 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AOD63_09015 ENOG4108IJ0 Aspartate ammonia-lyase AOD63_09020 ENOG4105C6K Malic enzyme AOD63_09090 ENOG4105FVX AOD63_09130 ENOG4105CSR polyphosphate kinase 2 AOD63_09150 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AOD63_09165 ENOG4105EU0 Major facilitator Superfamily AOD63_09170 ENOG4105C6T cysteine synthase AOD63_09190 ENOG4105C8J )-transporter AOD63_09200 ENOG4105X5K response regulator receiver protein AOD63_09205 ENOG4105H67 Protein of unknown function (DUF421) AOD63_09220 ENOG4106KE4 Dehydrogenase AOD63_09235 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AOD63_09240 ENOG4105CHR reductase AOD63_09245 ENOG4105CM2 brancheD-chain amino acid aminotransferase AOD63_09250 ENOG4105C7K acetolactate synthase AOD63_09255 ENOG4108ZP8 Acetolactate synthase small subunit AOD63_09260 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AOD63_09270 ENOG4105C7B Threonine dehydratase AOD63_09295 ENOG4105C6X Major Facilitator AOD63_09300 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AOD63_09310 ENOG4105DY9 regulatoR AOD63_09315 ENOG4105CYC Transferase AOD63_09335 ENOG4105F6J Alpha beta hydrolase fold AOD63_09340 ENOG4108J59 Extracellular solute-binding protein, family 5 AOD63_09370 ENOG41068WN AOD63_09390 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AOD63_09395 ENOG4105C72 UPF0176 protein AOD63_09405 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AOD63_09440 ENOG4107RHR regulatoR AOD63_09450 ENOG4105D9N nucleoside AOD63_09455 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AOD63_09490 ENOG4107RAQ aminopeptidase AOD63_09495 ENOG4107STQ Multicopper oxidase AOD63_09540 ENOG4108T5E Copper resistance protein AOD63_09545 ENOG4105KTB nuclear export factor GLE1 AOD63_09555 ENOG4107RT3 EamA-like transporter family AOD63_09560 ENOG4105GZI Transcriptional regulator AOD63_09565 ENOG4108Z40 Transcriptional regulator AOD63_09570 ENOG4107ZXU DSBA oxidoreductase AOD63_09575 ENOG4108TVJ Nitroreductase AOD63_09585 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AOD63_09590 ENOG4106F5Q Membrane AOD63_09595 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOD63_09605 ENOG4105CKI cobalamin synthesis protein AOD63_09625 ENOG4108Z7G MaoC domain protein dehydratase AOD63_09630 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOD63_09640 ENOG4105C0Z ABC transporter AOD63_09645 ENOG4108IV0 ABC, transporter AOD63_09650 ENOG4105C32 Amino acid ABC transporter (Permease) AOD63_09660 ENOG4105SKE transcriptional Regulator LysR family AOD63_09680 ENOG4105YGB Transcriptional regulator AOD63_09690 ENOG4105C4M (Ubiquinol oxidase) subunit I AOD63_09695 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AOD63_09700 ENOG4108JJ9 ABC, transporter AOD63_09705 ENOG4108JJ8 (ABC) transporter AOD63_09750 ENOG4105BZ1 (ABC) transporter AOD63_09755 ENOG4105BZ1 (ABC) transporter AOD63_09760 ENOG4105EFI regulatoR AOD63_09765 ENOG4105BZU Histidine kinase AOD63_09785 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AOD63_09790 ENOG4108ZJ4 polysaccharide deacetylase AOD63_09810 ENOG4105D6E homoserine dehydrogenase AOD63_09835 ENOG4108KGH TRANSCRIPTIONal AOD63_09845 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD63_09850 ENOG4105BZU Histidine kinase AOD63_09855 ENOG4107VMI polysaccharide deacetylase AOD63_09865 ENOG4105KT7 mgtC SapB transporter AOD63_09870 ENOG4105VRR gCN5-related N-acetyltransferase AOD63_09880 ENOG4105DUU IucA IucC family protein AOD63_09885 ENOG4105CEY Amp-dependent synthetase and ligase AOD63_09900 ENOG4108WBH protein TIM barrel AOD63_09905 ENOG4105YWU small acid-soluble spore protein AOD63_09915 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AOD63_09965 ENOG4105KRN Transcriptional regulator, abrb family AOD63_09975 ENOG4105YVS arsR family transcriptional regulator AOD63_09980 ENOG4107SET aldo keto reductase AOD63_09985 ENOG4107XZQ multidrug resistance protein AOD63_10010 ENOG4105C8Q Methyl-accepting chemotaxis AOD63_10030 ENOG4108K88 Membrane AOD63_10035 ENOG4108WPJ Ferritin-like domain AOD63_10050 ENOG4105DEN Luciferase family AOD63_10070 ENOG4107QM2 Aldo Keto reductase AOD63_10075 ENOG4105CKI cobalamin synthesis protein AOD63_10140 ENOG4105DSE periplasmic solute binding protein AOD63_10150 ENOG4105K4T epimerase AOD63_10160 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AOD63_10185 ENOG4105CVJ phosphoglycerate mutase AOD63_10205 ENOG4107T5V SNARE associated Golgi AOD63_10220 ENOG4108PJD permease AOD63_10230 ENOG4108S4H thioesterase Superfamily protein AOD63_10235 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOD63_10255 ENOG4105SXS Protein of unknown function (DUF456) AOD63_10260 ENOG4105C37 (CBS) domain AOD63_10280 ENOG4108Z7R Chaperone CsaA AOD63_10300 ENOG4108ZRV stage ii sporulation protein p AOD63_10310 ENOG4108VXD carboxy-peptidase AOD63_10320 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AOD63_10345 ENOG4108X4Q Hydrolase AOD63_10355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AOD63_10360 ENOG4107RBS Methyltransferase AOD63_10375 ENOG41087PP glycosyltransferase MGT family AOD63_10380 ENOG4108JYZ YitT family AOD63_10385 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AOD63_10410 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AOD63_10460 ENOG4105KBJ sporulation protein ytfj AOD63_10485 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AOD63_10505 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AOD63_10510 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AOD63_10520 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AOD63_10525 ENOG4105EMN RNA polymerase sigma factor AOD63_10550 ENOG4108V06 Glutathione peroxidase AOD63_10565 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOD63_10585 ENOG4108IUE nitrate reductase beta subunit AOD63_10590 ENOG4105R3A Nitrate reductase AOD63_10615 ENOG4107V6Q Cyclic nucleotide-binding domain AOD63_10620 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AOD63_10625 ENOG4105D06 uba thif-type nad fad binding protein AOD63_10630 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOD63_10635 ENOG4108ZAF Molybdopterin AOD63_10660 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AOD63_10665 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AOD63_10670 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AOD63_10675 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AOD63_10680 ENOG4108IFG nitrite reductase, (NAD(P)H) AOD63_10685 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AOD63_10720 ENOG4105MCT stage V sporulation protein S AOD63_10735 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AOD63_10755 ENOG4105C5H ABC transporter AOD63_10770 ENOG4108UUM single-stranded DNA-binding protein AOD63_10785 ENOG41061H0 Monooxygenase AOD63_10805 ENOG4107YX5 Pfam:DUF548 AOD63_10810 ENOG4105C75 arginyL-tRNA synthetase AOD63_10835 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AOD63_10850 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AOD63_10855 ENOG4105C5S asparaginyl-tRNA synthetase AOD63_10875 ENOG4105EC2 ftsk spoIIIe AOD63_10970 ENOG4105BZW Glycerate kinase AOD63_10975 ENOG4107QPK )-transporter AOD63_10980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD63_10985 ENOG41062D9 Histidine kinase AOD63_11000 ENOG4105C8J )-transporter AOD63_11020 ENOG4107XGZ Hydrolase AOD63_11025 ENOG4105CY2 Citrate transporter AOD63_11030 ENOG4105C0A alcohol dehydrogenase AOD63_11045 ENOG4105KD7 acetyltransferase AOD63_11075 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AOD63_11095 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AOD63_11110 ENOG4107RVG penicillin-binding protein AOD63_11115 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AOD63_11120 ENOG4105E9Q Acyl-transferase AOD63_11125 ENOG4108UT2 hemolysin iii AOD63_11135 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AOD63_11145 ENOG4108RCR degv family AOD63_11150 ENOG4105E8R UPF0173 metal-dependent hydrolase AOD63_11155 ENOG4108KF3 Electron transport protein SCO1 SenC AOD63_11160 ENOG4107Y70 Heat shock protein AOD63_11165 ENOG4105CAQ asparagine synthetase AOD63_11185 ENOG4108MES Periplasmic binding protein AOD63_11190 ENOG4105F0I Aminotransferase AOD63_11225 ENOG4105D8X mechanosensitive ion channel AOD63_11230 ENOG4105BZU Histidine kinase AOD63_11235 ENOG4105WH1 Two component transcriptional regulator luxr family AOD63_11245 ENOG4106KNT transcriptional regulator AOD63_11280 ENOG4105CMG Carbohydrate kinase AOD63_11285 ENOG4105CMG Carbohydrate kinase AOD63_11315 ENOG4108IJ8 ABC transporter AOD63_11320 ENOG4105E90 ABC transporter AOD63_11355 ENOG4105C37 (CBS) domain AOD63_11380 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOD63_11395 ENOG4107S4Y M20 DapE family protein YgeY AOD63_11400 ENOG4108TSC N-acetyltransferase AOD63_11405 ENOG4108JUB Transcriptional regulator AOD63_11410 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AOD63_11450 ENOG4108N23 SpoOM-related protein AOD63_11455 ENOG410841Q phosphoesterase PA-phosphatase related protein AOD63_11465 ENOG4105SZ6 Thioredoxin AOD63_11480 ENOG4108IBT Inherit from COG: transposase AOD63_11580 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOD63_11620 ENOG4105BZ4 penicillin-binding protein AOD63_11630 ENOG4105CZM Major Facilitator AOD63_11635 ENOG4105W8X HesB YadR YfhF-family protein AOD63_11645 ENOG4105DXD 2-methylcitrate dehydratase AOD63_11650 ENOG4105CR4 methylisocitrate lyase AOD63_11655 ENOG4105C1G acyl-Coa dehydrogenase AOD63_11660 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AOD63_11670 ENOG4105N14 lysine exporter protein LysE YggA AOD63_11675 ENOG4105E39 Enoyl-CoA hydratase AOD63_11690 ENOG4107RFY SbcCD D subunit AOD63_11695 ENOG4105EYH Exonuclease AOD63_11725 ENOG4105FCD Major Facilitator AOD63_11730 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AOD63_11735 ENOG4105E4F Isochorismate synthase AOD63_11740 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AOD63_11745 ENOG4105WQI isochorismatase AOD63_11750 ENOG4105CEY Amp-dependent synthetase and ligase AOD63_11755 ENOG4105WQT MbtH domain protein AOD63_11760 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD63_11775 ENOG4105K70 DNA-binding protein AOD63_11795 ENOG4105BZG amino acid carrier protein AOD63_11820 ENOG4105FE9 pseudouridine synthase AOD63_11825 ENOG4105C22 threonyL-tRNA synthetase AOD63_11840 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AOD63_11865 ENOG4108D32 Methyltransferase AOD63_11895 ENOG41081I9 integral membrane protein AOD63_11910 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AOD63_11920 ENOG4105EYF MMPL domain protein AOD63_11945 ENOG4105WCN acetyltransferase AOD63_11975 ENOG4105C1Q protoporphyrinogen oxidase AOD63_11985 ENOG41068WN AOD63_11995 ENOG4105VEQ Cold shock protein AOD63_12015 ENOG410667J hydrolase AOD63_12060 ENOG4107V2S Transcriptional regulator AOD63_12065 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AOD63_12080 ENOG4105DND Transcriptional regulator AOD63_12085 ENOG4108RPX mosc domain containing protein AOD63_12100 ENOG4105BZ1 (ABC) transporter AOD63_12105 ENOG4105BZ1 (ABC) transporter AOD63_12125 ENOG4108JCI Transcriptional regulator AOD63_12155 ENOG4108KPJ rna polymerase sigma factor AOD63_12180 ENOG4105F32 YngK protein AOD63_12205 ENOG4105RD7 BadF BadG BcrA BcrD AOD63_12215 ENOG4107STF Involved in phosphonate degradation (By similarity) AOD63_12235 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AOD63_12250 ENOG4105C1J atp-dependent rna helicase AOD63_12265 ENOG4108RZE Tetr family transcriptional regulator AOD63_12285 ENOG41088CC tellurite resistance protein tehB AOD63_12295 ENOG4108I0C methyltransferase AOD63_12300 ENOG4107RA9 decarboxylase AOD63_12305 ENOG41090HR transcriptional regulator AOD63_12345 ENOG4105CIN aminoacyl-histidine dipeptidase AOD63_12370 ENOG4107RF6 penicillin-binding protein AOD63_12385 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AOD63_12390 ENOG4105ETE Transcriptional regulator (LacI family AOD63_12395 ENOG4105IE8 Alpha-ketoglutarate permease AOD63_12400 ENOG4105CK5 oxidoreductase AOD63_12425 ENOG4105D2N Aldolase AOD63_12430 ENOG4105DH8 myo-inositol catabolism AOD63_12445 ENOG4105CGH 5'-nucleotidase AOD63_12455 ENOG4105CGH 5'-nucleotidase AOD63_12470 ENOG4105VZ8 Transcriptional regulator AOD63_12485 ENOG4108VXD carboxy-peptidase AOD63_12505 ENOG41067SE Tetr family transcriptional regulator AOD63_12510 ENOG4105C5H ABC transporter AOD63_12520 ENOG4105BZU Histidine kinase AOD63_12530 ENOG4106ANW SMI1_KNR4 AOD63_12535 ENOG4105CEP NADH dehydrogenase AOD63_12540 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AOD63_12555 ENOG4105CJ1 ABC, transporter AOD63_12565 ENOG4107Z3H Transcriptional regulator, TetR family AOD63_12580 ENOG4105C1G acyl-Coa dehydrogenase AOD63_12585 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AOD63_12590 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AOD63_12595 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AOD63_12600 ENOG4105E39 Enoyl-CoA hydratase AOD63_12605 ENOG4107QX3 carboxylase AOD63_12610 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AOD63_12620 ENOG4105WCN acetyltransferase AOD63_12625 ENOG4105DBI uridine monophosphokinase AOD63_12660 ENOG4105T9C HD domain AOD63_12670 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AOD63_12710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOD63_12710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOD63_12725 ENOG4105FQP Beta-lactamase AOD63_12735 ENOG4107Y80 Major Facilitator superfamily AOD63_12755 ENOG4105CUV Homoserine Kinase AOD63_12790 ENOG4105CPQ Dehydrogenase AOD63_12805 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOD63_12810 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOD63_12905 ENOG4105ETU transcriptional activator (TenA AOD63_13015 ENOG410667J hydrolase AOD63_13025 ENOG4105BZU Histidine kinase AOD63_13030 ENOG4107RF6 penicillin-binding protein AOD63_13050 ENOG4108JJB ABC transporter AOD63_13060 ENOG4108HGU Histidine kinase AOD63_13075 ENOG4105CB2 alcohol dehydrogenase AOD63_13080 ENOG4105CJN penicillin-binding protein AOD63_13090 ENOG4105FQP Beta-lactamase AOD63_13125 ENOG4108V4B ThiJ pfpI AOD63_13155 ENOG4107Y80 Major Facilitator superfamily AOD63_13170 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AOD63_13190 ENOG4107Y9U Membrane AOD63_13225 ENOG4105FCD Major Facilitator AOD63_13240 ENOG4105E09 nadh pyrophosphatase AOD63_13245 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AOD63_13250 ENOG4108Z4K mutator MutT protein AOD63_13285 ENOG4108XI2 Domain of unknown function (DUF1963) AOD63_13315 ENOG4108NRW Phospholipase, patatin family AOD63_13320 ENOG4105KWG Pfam:DUF1696 AOD63_13355 ENOG4105PKS Excinuclease abc c subunit domain protein AOD63_13395 ENOG4107VFR oxidoreductase AOD63_13420 ENOG4105PAD Hydrolase AOD63_13440 ENOG4105DY8 decarboxylase AOD63_13455 ENOG4108IUM Glycogen debranching enzyme AOD63_13480 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AOD63_13490 ENOG4105FDR Membrane AOD63_13525 ENOG4108V3A UPF0421 protein AOD63_13545 ENOG4105MSI germination protein ypeb AOD63_13565 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AOD63_13570 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AOD63_13575 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AOD63_13580 ENOG4107Z3H Transcriptional regulator, TetR family AOD63_13610 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AOD63_13630 ENOG4105E98 transcriptional regulator DeoR family AOD63_13650 ENOG41062ES Transcriptional regulator AOD63_13670 ENOG4107QKR Dehydrogenase AOD63_13680 ENOG4107RUY (E1 component), alpha subunit AOD63_13690 ENOG4105E1F short-chain dehydrogenase reductase AOD63_13695 ENOG4105RHY Pfam:UPF0157 AOD63_13730 ENOG4107SQ8 Glycine betaine AOD63_13735 ENOG4108IJ7 Glycine betaine AOD63_13760 ENOG4105E66 phosphoriboisomerase A AOD63_13765 ENOG41082BV acetyltransferase AOD63_13770 ENOG4108M1A Chitin-binding protein AOD63_13815 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AOD63_13865 ENOG4105EEM helicase AOD63_13885 ENOG4105C9U ATP-dependent DNA helicase RecQ AOD63_13940 ENOG4108M1A Chitin-binding protein AOD63_13955 ENOG4105BZG amino acid carrier protein AOD63_13960 ENOG4105C26 Dehydrogenase AOD63_13965 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AOD63_13970 ENOG4105CTU Proline racemase AOD63_13975 ENOG4105CTU Proline racemase AOD63_13980 ENOG41080HI glycine oxidase AOD63_14020 ENOG4107T5V SNARE associated Golgi AOD63_14035 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AOD63_14040 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AOD63_14055 ENOG4105DTQ mandelate racemase muconate lactonizing AOD63_14095 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AOD63_14100 ENOG4105BZU Histidine kinase AOD63_14105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD63_14145 ENOG4105EPR degv family AOD63_14185 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AOD63_14190 ENOG4106K7D Major facilitator family transporter AOD63_14210 ENOG4107BMA Transglycosylase associated protein AOD63_14225 ENOG41089UC methyltransferase, type 11 AOD63_14260 ENOG4105CHM Aminotransferase AOD63_14295 ENOG4105DVE abc transporter atp-binding protein AOD63_14345 ENOG4105C02 permease AOD63_14360 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AOD63_14365 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AOD63_14370 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AOD63_14395 ENOG4105E09 nadh pyrophosphatase AOD63_14415 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AOD63_14465 ENOG4107VC0 DNA alkylation repair enzyme AOD63_14475 ENOG4107VMI polysaccharide deacetylase AOD63_14485 ENOG4108ZCF integral membrane protein AOD63_14490 ENOG4105E0M Sulfatase AOD63_14495 ENOG4105C5H ABC transporter AOD63_14505 ENOG4105EYF MMPL domain protein AOD63_14510 ENOG4105EYF MMPL domain protein AOD63_14515 ENOG4105EYF MMPL domain protein AOD63_14520 ENOG41082JN Transcriptional regulator AOD63_14540 ENOG4105CIH Imidazole acetol-phosphate transaminase AOD63_14545 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AOD63_14550 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AOD63_14585 ENOG41069ER domain protein AOD63_14595 ENOG4105EMN RNA polymerase sigma factor AOD63_14620 ENOG4105D4B ABC, transporter AOD63_14630 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AOD63_14640 ENOG4105DKT Transcriptional regulator AOD63_14655 ENOG41061GT Aldolase AOD63_14675 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AOD63_14705 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AOD63_14710 ENOG4105II7 pyrroline-5-carboxylate reductase AOD63_14720 ENOG4107258 Transcriptional regulator AOD63_14730 ENOG4105E0Y RtcB Protein AOD63_14735 ENOG4105ECK Fatty Acid Desaturase AOD63_14740 ENOG4105G6Z alkaline phosphatase AOD63_14750 ENOG4105VMP Transcriptional regulator AOD63_14765 ENOG41090T1 Membrane AOD63_14775 ENOG4108WCX response regulator AOD63_14785 ENOG41068WN AOD63_14810 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOD63_14835 ENOG4105CKK Glycosyl transferase, family 2 AOD63_14860 ENOG4105CKK Glycosyl transferase, family 2 AOD63_14870 ENOG4105C8Y Acetylornithine aminotransferase AOD63_14910 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOD63_14920 ENOG4108TVJ Nitroreductase AOD63_14925 ENOG4105FS7 Transcriptional regulator AOD63_14960 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOD63_14970 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AOD63_15000 ENOG4108XET gCN5-related N-acetyltransferase AOD63_15080 ENOG410635A Membrane AOD63_15085 ENOG4105KNA -acetyltransferase AOD63_15090 ENOG4108IQI permease AOD63_15100 ENOG4105F1N DNA alkylation repair AOD63_15140 ENOG4107RF6 penicillin-binding protein AOD63_15150 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AOD63_15190 ENOG4105P4J Allophanate hydrolase, subunit 1 AOD63_15195 ENOG4107258 Transcriptional regulator AOD63_15205 ENOG4106N3A copper homeostasis protein cutc AOD63_15210 ENOG4108ZRV stage ii sporulation protein p AOD63_15215 ENOG4108ZHR arsR family transcriptional regulator AOD63_15225 ENOG4105FDT acyl-CoA dehydrogenase AOD63_15245 ENOG4105DWD nucleoside recognition domain protein AOD63_15275 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AOD63_15340 ENOG4105E2A Dehydrogenase AOD63_15355 ENOG4108IJ0 Aspartate ammonia-lyase AOD63_15360 ENOG4105HDK L-asparaginase AOD63_15365 ENOG4108IMY Transcriptional regulator AOD63_15375 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AOD63_15380 ENOG4105CUB amino acid AOD63_15390 ENOG4105II7 pyrroline-5-carboxylate reductase AOD63_15400 ENOG4105C6K Malic enzyme AOD63_15410 ENOG4108NHD germination protein AOD63_15415 ENOG4108NHD germination protein AOD63_15420 ENOG4108Q8B Spore germination protein AOD63_15440 ENOG4105CSV Glutaminase AOD63_15470 ENOG4105CGH 5'-nucleotidase AOD63_15475 ENOG4105CH6 catalase AOD63_15485 ENOG4105CHJ isochorismatase hydrolase AOD63_15550 ENOG4108606 TspO/MBR family AOD63_15555 ENOG4105CVP deoxyribo-dipyrimidine photolyase AOD63_15570 ENOG4108TWJ NADH dehydrogenase subunit 5 AOD63_15575 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AOD63_15585 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AOD63_15590 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AOD63_15595 ENOG4105DSE periplasmic solute binding protein AOD63_15600 ENOG4105CC5 ABC transporter AOD63_15605 ENOG4105DIK (ABC) transporter AOD63_15635 ENOG4105D6J arsenicaL-resistance protein AOD63_15640 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AOD63_15645 ENOG41085FC arsR family transcriptional regulator AOD63_15660 ENOG4105F7F Chaperone AOD63_15670 ENOG4105CHR reductase AOD63_15675 ENOG4108YXU transcriptional regulator AsnC family AOD63_15750 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AOD63_15760 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD63_15770 ENOG4105IIP Membrane AOD63_15785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD63_15790 ENOG41062D9 Histidine kinase AOD63_15820 ENOG4105K6H D-cysteine desulfhydrase AOD63_15845 ENOG4105VZ8 Transcriptional regulator AOD63_15860 ENOG4108NNI Beta-lactamase domain-containing protein AOD63_15865 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AOD63_15875 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOD63_15880 ENOG4105JQZ Methyltransferase AOD63_15895 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AOD63_15900 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AOD63_15920 ENOG4105BZU Histidine kinase AOD63_15935 ENOG4108U05 Transcriptional regulator AOD63_15950 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AOD63_15955 ENOG4105DJB Major Facilitator Superfamily AOD63_15960 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AOD63_15965 ENOG4107QR9 Iron-sulfur cluster binding protein AOD63_15975 ENOG4106P55 Transcriptional regulator AOD63_15985 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AOD63_16020 ENOG4105TRI Hydrolase AOD63_16055 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AOD63_16085 ENOG4107QJQ Mate efflux family protein AOD63_16100 ENOG4105EQ0 Major Facilitator superfamily AOD63_16105 ENOG4108JGH Tetr family transcriptional regulator AOD63_16120 ENOG4105C44 Serine transporter AOD63_16125 ENOG4105EJQ L-serine dehydratase AOD63_16140 ENOG4108JPW Aminotransferase AOD63_16155 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AOD63_16165 ENOG4105DVH amino acid AOD63_16180 ENOG4108JQ1 Dehydrogenase AOD63_16200 ENOG4108AEY RNA polymerase sigma factor AOD63_16215 ENOG41082W1 Cupin 2, conserved barrel domain protein AOD63_16225 ENOG410874W AraC family transcriptional regulator AOD63_16240 ENOG4105HIR S-layer domain protein AOD63_16280 ENOG4108ISG Major Facilitator AOD63_16290 ENOG4107MII Sugar-specific transcriptional regulator TrmB AOD63_16295 ENOG4105CZM Major Facilitator AOD63_16315 ENOG4105DA5 (ABC) transporter AOD63_16320 ENOG41069JR AOD63_16330 ENOG4105RXJ AOD63_16335 ENOG4105KPY Small multidrug resistance protein AOD63_16340 ENOG4105KBX Transcriptional regulator, TetR family AOD63_16355 ENOG4105CRW Short chain fatty acid transporter AOD63_16365 ENOG4105DYS nad(p)h dehydrogenase (quinone) AOD63_16395 ENOG4108JJB ABC transporter AOD63_16400 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AOD63_16425 ENOG4108K8S endonuclease I AOD63_16440 ENOG41067QW Transcriptional regulator AOD63_16450 ENOG4108Z66 YbaK ebsC protein AOD63_16455 ENOG4105CUT histidyl-tRNA synthetase AOD63_16470 ENOG4105KVH Transcriptional regulator AOD63_16475 ENOG4108RCM Nitroreductase AOD63_16495 ENOG4108PSK reductase AOD63_16505 ENOG4105CJ1 ABC, transporter AOD63_16565 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AOD63_16570 ENOG4105DKQ ROK family AOD63_16575 ENOG4106UW1 Major Facilitator superfamily AOD63_16580 ENOG4108UW5 maltose o-acetyltransferase AOD63_16595 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AOD63_16600 ENOG4105C31 Tryptophanyl-tRNA synthetase AOD63_16605 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AOD63_16630 ENOG4105DMQ Methyltransferase AOD63_16640 ENOG4105EV4 Multidrug resistance protein mdtH AOD63_16670 ENOG4105C37 (CBS) domain AOD63_16685 ENOG4105DDN Pentapeptide repeat-containing protein AOD63_16690 ENOG4105XDF Protein of unknown function (DUF1272) AOD63_16695 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AOD63_16700 ENOG4105CMG Carbohydrate kinase AOD63_16705 ENOG4105C6Z Gluconate AOD63_16710 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AOD63_16725 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AOD63_16730 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AOD63_16735 ENOG4105CIS alcohol dehydrogenase AOD63_16740 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AOD63_16760 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AOD63_16765 ENOG4105D4Y metalloprotease AOD63_16785 ENOG4105CV8 reductase AOD63_16790 ENOG4105F27 Major Facilitator AOD63_16805 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AOD63_16810 ENOG4105C44 Serine transporter AOD63_16845 ENOG4105KVH Transcriptional regulator AOD63_16850 ENOG4108TZY GntR Family Transcriptional Regulator AOD63_16860 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AOD63_16865 ENOG4105KVH Transcriptional regulator AOD63_16870 ENOG4105KVH Transcriptional regulator AOD63_16905 ENOG4105JAB phenazine biosynthesis protein, phzf family AOD63_16915 ENOG4105CHR reductase AOD63_16935 ENOG4105KVH Transcriptional regulator AOD63_17005 ENOG4105KAF membrAne AOD63_17030 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AOD63_17045 ENOG4107YXZ hydrolase, family 25 AOD63_17070 ENOG4105ED2 Beta-lactamase AOD63_17080 ENOG4105H3G oxidoreductase AOD63_17155 ENOG4108TN2 lmbE family AOD63_17165 ENOG4107R3E Citrate transporter AOD63_17185 ENOG4108MES Periplasmic binding protein AOD63_17195 ENOG4105EHG Permease protein AOD63_17200 ENOG4105DQ5 transport system permease protein AOD63_17205 ENOG4105NX3 Membrane AOD63_17210 ENOG4107ZY0 Phenazine biosynthesis-like protein AOD63_17230 ENOG4107CUJ Protein of unknown function (DUF2690) AOD63_17240 ENOG4107V2S Transcriptional regulator AOD63_17260 ENOG4105C98 muts2 protein AOD63_17270 ENOG4105E5K Alpha-amylase AOD63_17275 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AOD63_17280 ENOG4105DPN Oligoendopeptidase f AOD63_17285 ENOG4108A04 Beta-lactamase AOD63_17315 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AOD63_17340 ENOG41082BM Transcriptional regulator, arsr family AOD63_17345 ENOG4105CIS alcohol dehydrogenase AOD63_17370 ENOG4105RHY Pfam:UPF0157 AOD63_17380 ENOG4105C09 Bile acid AOD63_17385 ENOG4105CQB FAD linked oxidase domain protein AOD63_17410 ENOG4108UT6 Transferase hexapeptide repeat containing protein AOD63_17420 ENOG4105K64 Glycosyl transferase, family 2 AOD63_17425 ENOG4105E39 Enoyl-CoA hydratase AOD63_17435 ENOG4105KT7 mgtC SapB transporter AOD63_17445 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOD63_17450 ENOG41073R8 VanW family AOD63_17460 ENOG4108R1P AOD63_17480 ENOG4105VEQ Cold shock protein AOD63_17500 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AOD63_17520 ENOG410904N short-chain dehydrogenase reductase AOD63_17530 ENOG4106IQC argininosuccinate lyase AOD63_17545 ENOG4108IA2 Sodium pantothenate symporter AOD63_17555 ENOG4105C26 Dehydrogenase AOD63_17560 ENOG4105CHR reductase AOD63_17570 ENOG4105EWU Squalene--hopene cyclase AOD63_17580 ENOG4105FR1 rard protein AOD63_17585 ENOG410696E Membrane AOD63_17600 ENOG4105D1F ATP-binding protein AOD63_17610 ENOG4108ZAF Molybdopterin AOD63_17615 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOD63_17620 ENOG4105D06 uba thif-type nad fad binding protein AOD63_17625 ENOG4105TMB Formate nitrite transporter AOD63_17635 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AOD63_17640 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AOD63_17650 ENOG4108JB9 formate dehydrogenase AOD63_17660 ENOG4105E1K spore germination protein AOD63_17720 ENOG4107QJT sodium dicarboxylate symporter AOD63_17725 ENOG4108KGH TRANSCRIPTIONal AOD63_17735 ENOG4105EMN RNA polymerase sigma factor AOD63_17760 ENOG4105CIG ABC transporter AOD63_17770 ENOG4105D9R oxidoreductase AOD63_17780 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOD63_17790 ENOG4105K4P CoA-binding domain protein AOD63_17795 ENOG4105C0H protease AOD63_17800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD63_17810 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AOD63_17815 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AOD63_17820 ENOG4105W8X HesB YadR YfhF-family protein AOD63_17850 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AOD63_17855 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AOD63_17865 ENOG4108JJA ABC, transporter AOD63_17870 ENOG4108I0Z Aconitate hydratase AOD63_17900 ENOG4105E5W Transporter AOD63_17910 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOD63_17930 ENOG4107F3J Amp-dependent synthetase and ligase AOD63_17935 ENOG4107ZYJ bioY protein AOD63_17940 ENOG4105CEY Amp-dependent synthetase and ligase AOD63_17985 ENOG4107AYK membrAne AOD63_17995 ENOG4105BZU Histidine kinase AOD63_18000 ENOG4105FBA Phospholipase Carboxylesterase AOD63_18005 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AOD63_18010 ENOG4105CK7 Sodium proline symporter AOD63_18015 ENOG4105CBC glutamate synthase AOD63_18020 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AOD63_18025 ENOG4108VJ1 Transcriptional regulator (CarD family AOD63_18030 ENOG4108903 Formimidoylglutamase AOD63_18055 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AOD63_18115 ENOG4107QIV Cytochrome c biogenesis protein AOD63_18125 ENOG4107RSM transcriptional regulator AOD63_18130 ENOG4105VAW lrga family AOD63_18135 ENOG41067MG lrgb family AOD63_18160 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AOD63_18175 ENOG4105BZ1 (ABC) transporter AOD63_18180 ENOG4105BZ1 (ABC) transporter AOD63_18200 ENOG4105D7V transposase AOD63_18220 ENOG4105D5T phosphonate abc transporter AOD63_18235 ENOG4105CGH 5'-nucleotidase AOD63_18245 ENOG4108SVB resolvase AOD63_18265 ENOG4105K7K Transcriptional regulator AOD63_18300 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AOD63_18305 ENOG4105XSJ toxin secretion phage lysis holin AOD63_18515 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) AOD63_18620 ENOG4105C5F glutamine synthetase AOD63_18625 ENOG4105KV4 Transcriptional regulator AOD63_18630 ENOG4105CXI aluminum resistance protein AOD63_18640 ENOG4105EN6 Membrane AOD63_18645 ENOG4106F1P AAA ATPase, central domain protein AOD63_18675 ENOG41069ER domain protein AOD63_18680 ENOG4105DM4 PTS System AOD63_18685 ENOG4105DE4 1-phosphofructokinase AOD63_18690 ENOG4105E98 transcriptional regulator DeoR family AOD63_18700 ENOG4108SJC Membrane AOD63_18715 ENOG4105C85 amino acid AOD63_18730 ENOG4105TMB Formate nitrite transporter AOD63_18735 ENOG4105K70 DNA-binding protein AOD63_18740 ENOG4105C59 p-type ATPase AOD63_18745 ENOG410681U heavy metal transport detoxification protein AOD63_18750 ENOG4105VPX protein, conserved in bacteria AOD63_18760 ENOG4105NIV Esterase AOD63_18765 ENOG4105E0A ABC, transporter AOD63_18790 ENOG4105CGK Exodeoxyribonuclease III AOD63_18800 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AOD63_18805 ENOG4105D03 DNA-3-methyladenine glycosylase II AOD63_18835 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AOD63_18840 ENOG4105BZU Histidine kinase AOD63_18860 ENOG41067MG lrgb family AOD63_18875 ENOG4107TTQ Alpha beta hydrolase fold AOD63_18880 ENOG4107YEI lmbE family AOD63_18900 ENOG4105F0V Cell wall hydrolase AOD63_18905 ENOG4107R6R udp-galactopyranose mutase AOD63_18910 ENOG4105E0M Sulfatase AOD63_18915 ENOG410890F Dynamin family AOD63_18925 ENOG4107QHE Choloylglycine hydrolase AOD63_18950 ENOG4105DA5 (ABC) transporter AOD63_18975 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AOD63_18980 ENOG4105DQU oxidoreductase, subunit beta AOD63_18985 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AOD63_18990 ENOG4108IGT Dipeptidase AOD63_18995 ENOG4105MCT stage V sporulation protein S AOD63_19000 ENOG4105D48 metallophosphoesterase AOD63_19025 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AOD63_19040 ENOG4105XZV Protein of unknown function (DUF3243) AOD63_19045 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AOD63_19065 ENOG4105UIB (ABC) transporter AOD63_19070 ENOG4105UIB (ABC) transporter AOD63_19075 ENOG4108JQ9 ABC transporter AOD63_19080 ENOG4105DIH basic membrane AOD63_19085 ENOG4105FDP GntR family transcriptional regulator AOD63_19090 ENOG4107QZI cell division protein FtsK AOD63_19100 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AOD63_19115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AOD63_19125 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AOD63_19130 ENOG4108S0H Dipicolinic acid synthetase, b subunit AOD63_19135 ENOG4105E35 Dipicolinate synthase subunit A AOD63_19145 ENOG4105C1V Peptidase, M16 AOD63_19165 ENOG4105DTN riboflavin biosynthesis protein ribF AOD63_19170 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AOD63_19180 ENOG4105W7A Protein of unknown function (DUF503) AOD63_19190 ENOG4105VHM ribosomal protein AOD63_19195 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AOD63_19200 ENOG4105CHV Transcription elongation factor NusA AOD63_19210 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AOD63_19220 ENOG4105DZP Membrane-associated zinc metalloprotease AOD63_19225 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AOD63_19230 ENOG4105KNE Phosphatidate cytidylyltransferase AOD63_19235 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AOD63_19275 ENOG4108HE4 integrase family AOD63_19285 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AOD63_19295 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AOD63_19310 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AOD63_19335 ENOG4105VB6 UPF0109 protein AOD63_19355 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AOD63_19360 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AOD63_19375 ENOG4105CHR reductase AOD63_19380 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AOD63_19395 ENOG4105CB5 ATP-dependent DNA helicase recG AOD63_19400 ENOG4105DP4 dak2 domain fusion protein ylov AOD63_19405 ENOG4108ZAA Alkaline-shock protein AOD63_19420 ENOG4105FJ0 thiamine AOD63_19425 ENOG4105DJV ribulose-phosphate 3-epimerase AOD63_19430 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AOD63_19435 ENOG4105D9P serine threonine protein kinase AOD63_19440 ENOG4108ZF3 Phosphatase AOD63_19450 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AOD63_19460 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AOD63_19465 ENOG4105C25 Primosomal protein n' AOD63_19470 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AOD63_19490 ENOG4105DSJ YicC domain protein AOD63_19500 ENOG4105F23 Fibronectin-binding protein AOD63_19505 ENOG4105DC7 peptidase M24 AOD63_19560 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AOD63_19585 ENOG4105C34 Pseudouridine synthase AOD63_19600 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AOD63_19610 ENOG4105DBK s4 domain protein AOD63_19615 ENOG41067XK integral membrane protein AOD63_19625 ENOG4105DFA alanine racemase domain protein AOD63_19630 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AOD63_19635 ENOG4105WR5 sporulation protein, YlmC YmxH family AOD63_19645 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD63_19655 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AOD63_19660 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AOD63_19665 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AOD63_19670 ENOG4105D4A Cell wall formation (By similarity) AOD63_19675 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AOD63_19680 ENOG4105CNI cell division protein FtsW AOD63_19695 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOD63_19700 ENOG4105CJN penicillin-binding protein AOD63_19705 ENOG4105CJN penicillin-binding protein AOD63_19710 ENOG41068DC Essential cell division protein (By similarity) AOD63_19745 ENOG4105KNH Nucleic acid-binding protein AOD63_19795 ENOG4105XSJ toxin secretion phage lysis holin AOD63_19880 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AOD63_19890 ENOG4105CAR Terminase, large subunit AOD63_19980 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AOD63_19990 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD63_20045 ENOG4108IMY Transcriptional regulator AOD63_20070 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) AOD63_20080 ENOG41063PX domain protein AOD63_20085 ENOG4105D78 K07001 NTE family protein AOD63_20090 ENOG4105H20 Sporulation integral membrane protein YlbJ AOD63_20100 ENOG4106H78 methyltransferase AOD63_20120 ENOG4107TB6 phosphoglycerate mutase AOD63_20135 ENOG4106UY4 Inherit from COG: Scp-like extracellular AOD63_20185 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AOD63_20190 ENOG4105CNI cell division protein FtsW AOD63_20205 ENOG4108IAB Phoh family AOD63_20225 ENOG4105QA2 AOD63_20230 ENOG4105CI3 gtp-binding protein typa AOD63_20240 ENOG4105ECY inositol monophosphatase AOD63_20260 ENOG4105CXN decarboxylase AOD63_20305 ENOG4105C7S Dehydrogenase AOD63_20310 ENOG4105CPP Dehydrogenase, E1 component AOD63_20325 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AOD63_20330 ENOG4108X4Q Hydrolase AOD63_20340 ENOG4105CN5 Metallo-Beta-Lactamase AOD63_20345 ENOG4107ZYR domain protein AOD63_20380 ENOG4108XRC Protein of unknown function (DUF458) AOD63_20390 ENOG4107IN1 Protein of unknown function (DUF1797) AOD63_20405 ENOG4105EPM Diguanylate phosphodiesterase AOD63_20410 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AOD63_20425 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AOD63_20435 ENOG4105UIN AOD63_20500 ENOG4108HGU Histidine kinase AOD63_20510 ENOG4105CHM Aminotransferase AOD63_20515 ENOG4105FKQ transcriptional regulator AOD63_20520 ENOG4105EG2 ABC transporter, permease AOD63_20530 ENOG4107FKK extracellular solute-binding protein family 1 AOD63_20540 ENOG4105CG3 alpha amylase, catalytic region AOD63_20585 ENOG4105CHU acetyl-coa acetyltransferase AOD63_20625 ENOG4105K7K Transcriptional regulator AOD63_20630 ENOG4105DTD Dehydrogenase AOD63_20640 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AOD63_20650 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AOD63_20675 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AOD63_20695 ENOG4106TD9 Diguanylate cyclase AOD63_20715 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AOD63_20730 ENOG4105CID antiterminator AOD63_20740 ENOG4105FDP GntR family transcriptional regulator AOD63_20750 ENOG4105CE4 GlcNAc 6-P deacetylase AOD63_20795 ENOG4107ZE5 PPIases accelerate the folding of proteins AOD63_20800 ENOG4105PTM secreted protein AOD63_20805 ENOG4105J7I hydrolase AOD63_20815 ENOG4105G6R Stage v sporulation protein ae AOD63_20825 ENOG4105CZ3 stage V sporulation protein ad AOD63_20830 ENOG41090VF Stage v sporulation protein ac AOD63_20850 ENOG4105C8J )-transporter AOD63_20855 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD63_20865 ENOG41082AN stage II sporulation protein AOD63_20870 ENOG4105DZ1 carboxypeptidase AOD63_20875 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOD63_20880 ENOG4105DVE abc transporter atp-binding protein AOD63_20915 ENOG4105D7N magnesium and cobalt transport protein CorA AOD63_20940 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AOD63_20950 ENOG4105I3K Ferric uptake regulator, Fur family AOD63_20955 ENOG4105MZ9 stage II sporulation protein m AOD63_20975 ENOG4105CPC Aldo Keto reductase AOD63_20985 ENOG4105RHY Pfam:UPF0157 AOD63_21005 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AOD63_21015 ENOG4105ETE Transcriptional regulator (LacI family AOD63_21020 ENOG4108YM7 Gcn5-related n-acetyltransferase AOD63_21040 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AOD63_21045 ENOG4108R6K riboflavin synthase, subunit alpha AOD63_21065 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AOD63_21070 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOD63_21075 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOD63_21080 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AOD63_21090 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOD63_21100 ENOG4105DFD Na H antiporter AOD63_21105 ENOG4105CGH 5'-nucleotidase AOD63_21145 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AOD63_21160 ENOG4108IXY short-chain dehydrogenase reductase AOD63_21165 ENOG41069FQ Metallo-beta-lactamase superfamily AOD63_21175 ENOG4105II7 pyrroline-5-carboxylate reductase AOD63_21180 ENOG4105EJQ L-serine dehydratase AOD63_21205 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AOD63_21215 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AOD63_21220 ENOG4105D9U N-acetyltransferase AOD63_21235 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AOD63_21240 ENOG4108QEG Membrane AOD63_21245 ENOG4105CDA abc transporter atp-binding protein AOD63_21250 ENOG4105E5Q amino acid AbC transporter AOD63_21255 ENOG4108HW3 (ABC) transporter AOD63_21265 ENOG4105G7B Protein of unknown function (DUF2992) AOD63_21285 ENOG4105C7S Dehydrogenase AOD63_21290 ENOG4105CPP Dehydrogenase, E1 component AOD63_21310 ENOG4107RDP Dehydrogenase AOD63_21325 ENOG4108JUB Transcriptional regulator AOD63_21335 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AOD63_21350 ENOG4107QQR Sporulation AOD63_21360 ENOG4105S1Z Stage IV sporulation protein B AOD63_21365 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AOD63_21375 ENOG4105DX0 Hemolysin A AOD63_21385 ENOG4105CTB Polyprenyl synthetase AOD63_21410 ENOG4108ZSR alkaline shock protein AOD63_21415 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AOD63_21440 ENOG410644B Stage III sporulation protein af AOD63_21450 ENOG4105KQ4 Stage iii sporulation protein ad AOD63_21455 ENOG4108CQH stage III sporulation protein AC AOD63_21460 ENOG4105KR5 Stage iii sporulation protein AOD63_21465 ENOG4105CD2 stage iii sporulation protein aa AOD63_21490 ENOG4105DC7 peptidase M24 AOD63_21505 ENOG4105CBJ Metal-dependent enzyme AOD63_21515 ENOG4107YBY Hydrolase AOD63_21535 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AOD63_21540 ENOG4105WZW rhodanese family AOD63_21560 ENOG41080TC multidrug resistance protein AOD63_21600 ENOG4105CJ1 ABC, transporter AOD63_21605 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOD63_21635 ENOG4105C0D helicase AOD63_21755 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AOD63_21760 ENOG4105C3R Methionine synthase AOD63_21775 ENOG4105C28 cystathionine AOD63_21780 ENOG4105C28 cystathionine AOD63_21805 ENOG4105C5X domain protein AOD63_21815 ENOG4105DKQ ROK family AOD63_21825 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AOD63_21840 ENOG4108UTW Plays a role in the regulation of phosphate uptake AOD63_21845 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AOD63_21850 ENOG4105E2Z phosphate ABC transporter (Permease AOD63_21855 ENOG4105C8U phosphate abc transporter AOD63_21860 ENOG4105PWN phosphate abc transporter AOD63_21865 ENOG4107RF6 penicillin-binding protein AOD63_21875 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOD63_21900 ENOG4105N80 Ferric uptake regulator, Fur family AOD63_21910 ENOG4105FDK ABC transporter AOD63_21915 ENOG4108JYZ YitT family AOD63_21920 ENOG41069ZM Protein of unknown function (DUF2624) AOD63_21945 ENOG4105EGD dinuclear metal center protein, YbgI family AOD63_21960 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD63_21965 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AOD63_22000 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AOD63_22005 ENOG4105KG3 cytidine deaminase AOD63_22010 ENOG4107YR5 Diacylglycerol kinase AOD63_22020 ENOG4105CTJ Metal Dependent Phosphohydrolase AOD63_22025 ENOG4105C9A Phoh family AOD63_22040 ENOG41068P3 sporulation protein YqfC AOD63_22045 ENOG4105KTH gatB Yqey AOD63_22055 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AOD63_22060 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AOD63_22080 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AOD63_22090 ENOG4105CSA Coproporphyrinogen iii oxidase AOD63_22095 ENOG4105KVH Transcriptional regulator AOD63_22120 ENOG4105TQK DNA polymerase iii, delta' subunit AOD63_22130 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AOD63_22135 ENOG4108UK2 deaminase AOD63_22140 ENOG4105KQC Competence protein AOD63_22150 ENOG4105DXX methyltransferase AOD63_22160 ENOG4108WF2 Metal Dependent Phosphohydrolase AOD63_22170 ENOG410812S Rna-binding protein AOD63_22180 ENOG4105CQW ribosome biogenesis GTPase YqeH AOD63_22185 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AOD63_22200 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD63_22220 ENOG4108TVJ Nitroreductase AOD63_22235 ENOG4105G6Z alkaline phosphatase AOD63_22245 ENOG4108MUZ hydrolase AOD63_22280 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AOD63_22285 ENOG4105MIR Phenylalanine 4-monooxygenase AOD63_22295 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOD63_22300 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOD63_22340 ENOG4105S6R Iron-hydroxamate transporter permease subunit AOD63_22345 ENOG4108V5C ABC transporter AOD63_22355 ENOG4108EKI Dehydrogenase AOD63_22360 ENOG4105C28 cystathionine AOD63_22390 ENOG4107XRG penicillin-binding protein AOD63_22405 ENOG4105CFP Peptidase U32 AOD63_22410 ENOG4105XYU peptidase (U32 family) AOD63_22415 ENOG4108VQJ O-methyltransferase AOD63_22420 ENOG4105HHA aminodeoxychorismate lyase AOD63_22440 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOD63_22450 ENOG4105C02 permease AOD63_22465 ENOG41060CR AOD63_22470 ENOG4105C7H Helicase, RecD TraA family AOD63_22480 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AOD63_22485 ENOG4105C3J Cysteine desulfurase AOD63_22495 ENOG4105D1H recombination factor protein RarA AOD63_22500 ENOG4108VCI transcription factor, rsfa family AOD63_22505 ENOG4105CUZ uba thif-type nad fad binding protein AOD63_22515 ENOG4105CUT histidyl-tRNA synthetase AOD63_22530 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AOD63_22540 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AOD63_22545 ENOG41076HS cation diffusion facilitator family transporter AOD63_22550 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AOD63_22560 ENOG4105CKP Polysaccharide Biosynthesis Protein AOD63_22565 ENOG4108QG2 Membrane AOD63_22575 ENOG4105VIE preprotein translocase, subunit YajC AOD63_22590 ENOG41061AI Protein of unknown function (DUF2905) AOD63_22605 ENOG4108HUF Transporter AOD63_22615 ENOG4108IPJ Membrane AOD63_22620 ENOG4108IPJ Membrane AOD63_22625 ENOG41082BM Transcriptional regulator, arsr family AOD63_22650 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AOD63_22655 ENOG4108IYU L-aspartate oxidase AOD63_22670 ENOG4108RPX mosc domain containing protein AOD63_22675 ENOG4105CQC Prephenate dehydratase AOD63_22695 ENOG4105EWM Histidine kinase AOD63_22710 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AOD63_22725 ENOG4105X36 (ribosomal) protein AOD63_22735 ENOG4105C03 ribonuclease AOD63_22750 ENOG4107QMS site-determining protein AOD63_22765 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AOD63_22770 ENOG4105DFF Rod shape-determining protein mreb AOD63_22790 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AOD63_22795 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AOD63_22805 ENOG41068KH stage VI sporulation protein D AOD63_22815 ENOG4105D52 delta-aminolevulinic acid dehydratase AOD63_22840 ENOG4105K56 Transcriptional regulator AOD63_22860 ENOG4108IUQ atp-dependent protease AOD63_22890 ENOG4108QCI YvbH-like oligomerisation region AOD63_22910 ENOG4105M59 Phosphodiesterase, mj0936 family AOD63_22915 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AOD63_22925 ENOG4108XJQ germination protein AOD63_22935 ENOG4108PCX Major Facilitator AOD63_22945 ENOG4105KBX Transcriptional regulator, TetR family AOD63_22960 ENOG4105PFC Transcriptional regulator AOD63_22975 ENOG4105DZC cytosine deaminase AOD63_22980 ENOG4105DZC cytosine deaminase AOD63_22985 ENOG4105DEF Extracellular solute-binding protein, family 5 AOD63_22990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD63_23005 ENOG4108JQ7 (ABC) transporter AOD63_23010 ENOG4108HRK Histidine kinase AOD63_23015 ENOG4105DY9 regulatoR AOD63_23030 ENOG41067S9 phage shock protein C, PspC AOD63_23035 ENOG4108JCI Transcriptional regulator AOD63_23045 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AOD63_23050 ENOG4108Z40 Transcriptional regulator AOD63_23055 ENOG4105RHA ABC transporter, permease AOD63_23060 ENOG4108IUX (ABC) transporter AOD63_23065 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AOD63_23075 ENOG4105E14 MotA TolQ exbB proton channel AOD63_23080 ENOG4108VXD carboxy-peptidase AOD63_23090 ENOG4105E33 succinate dehydrogenase AOD63_23100 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AOD63_23115 ENOG4105K63 Thioredoxin AOD63_23120 ENOG4105C10 Electron transfer flavoprotein AOD63_23125 ENOG4105BZJ Electron transfer flavoprotein AOD63_23130 ENOG41060WC Enoyl-CoA hydratase AOD63_23135 ENOG4107Z3H Transcriptional regulator, TetR family AOD63_23140 ENOG4105CEY Amp-dependent synthetase and ligase AOD63_23150 ENOG4105J76 Periplasmic binding protein AOD63_23155 ENOG4105S6R Iron-hydroxamate transporter permease subunit AOD63_23200 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD63_23215 ENOG4105DR4 Methyltransferase AOD63_23230 ENOG4105KFN sortase, SrtB family AOD63_23235 ENOG4105E0A ABC, transporter AOD63_23250 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AOD63_23260 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AOD63_23270 ENOG4105FE9 pseudouridine synthase AOD63_23285 ENOG4105DCG PHP domain protein AOD63_23320 ENOG4105C5S asparaginyl-tRNA synthetase AOD63_23325 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AOD63_23335 ENOG4108RWN rrna methyltransferase AOD63_23370 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD63_23375 ENOG4105CW7 secretion protein, HlyD family AOD63_23380 ENOG4108JGH Tetr family transcriptional regulator AOD63_23385 ENOG4105CN9 Peptidase m42 family protein AOD63_23405 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AOD63_23410 ENOG4105C22 threonyL-tRNA synthetase AOD63_23415 ENOG4108TDW sporulation protein YtxC AOD63_23435 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AOD63_23440 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AOD63_23445 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AOD63_23455 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AOD63_23460 ENOG4105C2M dna polymerase I AOD63_23465 ENOG4105BZU Histidine kinase AOD63_23470 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD63_23490 ENOG4108HMX isocitrate dehydrogenase (NADP) AOD63_23495 ENOG4105BZN citrate synthase AOD63_23510 ENOG4108REF Sporulation integral membrane protein ytvi AOD63_23515 ENOG4105FS0 cytoplasmic membrane protein AOD63_23540 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AOD63_23545 ENOG4105C6K Malic enzyme AOD63_23550 ENOG4105C0B DNA polymerase III (alpha subunit) AOD63_23555 ENOG4105VV2 AOD63_23565 ENOG4105SFS phosphoesterase RecJ domain protein AOD63_23600 ENOG4105DC7 peptidase M24 AOD63_23635 ENOG4105Z7P Acetyltransferase (GNAT) family AOD63_23640 ENOG41082W1 Cupin 2, conserved barrel domain protein AOD63_23650 ENOG4105VZ8 Transcriptional regulator AOD63_23670 ENOG4107YZX Universal stress protein AOD63_23710 ENOG4108JYZ YitT family AOD63_23730 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AOD63_23740 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AOD63_23745 ENOG4105KBJ sporulation protein ytfj AOD63_23760 ENOG4105EFZ amidohydrolase AOD63_23770 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AOD63_23795 ENOG4106KR7 LysR family Transcriptional regulator AOD63_23815 ENOG4105C28 cystathionine AOD63_23835 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AOD63_23845 ENOG4105EMN RNA polymerase sigma factor AOD63_23860 ENOG4105F1V Acetoin utilization protein AOD63_23865 ENOG4105W87 Cbs domain AOD63_23870 ENOG4105DGU Histone deacetylase AOD63_23880 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD63_23890 ENOG4107SNB ankyrin repeat protein YahD AOD63_23895 ENOG4105EP9 oxidoreductase AOD63_23925 ENOG4105ETE Transcriptional regulator (LacI family AOD63_23950 ENOG4105C88 aminopeptidase AOD63_23995 ENOG4108VDD TRNA binding domain protein AOD63_24025 ENOG4105C8F Beta-lactamase domain protein AOD63_24040 ENOG4108V15 phosphotransferase enzyme family AOD63_24045 ENOG4108IUM Glycogen debranching enzyme AOD63_24060 ENOG4107QSE Dipeptidase AOD63_24065 ENOG4107QSE Dipeptidase AOD63_24070 ENOG4105YW5 deoR family transcriptional regulator AOD63_24085 ENOG4105CBX hi0933 family AOD63_24120 ENOG4108VJ1 Transcriptional regulator (CarD family AOD63_24125 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AOD63_24130 ENOG4105CSC Glucose uptake protein AOD63_24145 ENOG4108ZAF Molybdopterin AOD63_24150 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AOD63_24155 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOD63_24165 ENOG4105D06 uba thif-type nad fad binding protein AOD63_24190 ENOG41085GJ domain protein AOD63_24200 ENOG4105DWV Homoserine O-trans-acetylase AOD63_24210 ENOG4108B31 Spore germination protein AOD63_24245 ENOG410605W Major Facilitator AOD63_24250 ENOG4107S91 Sodium hydrogen exchanger AOD63_24255 ENOG4105NCW Trka-c domain protein AOD63_24270 ENOG4105C19 ABC transporter AOD63_24290 ENOG4105N5T Radical SAM Protein AOD63_24300 ENOG4105DA5 (ABC) transporter AOD63_24330 ENOG4105E8V Alpha Beta Hydrolase Fold protein AOD63_24335 ENOG4108Z0R Transferase AOD63_24340 ENOG4105YVM Phosphoesterase, PA-phosphatase related AOD63_24345 ENOG4105BZF Glycosyl transferase (Group 1 AOD63_24355 ENOG4108RIR Molybdenum cofactor biosynthesis protein AOD63_24410 ENOG4105EGD dinuclear metal center protein, YbgI family AOD63_24415 ENOG4105BZU Histidine kinase AOD63_24420 ENOG4105BZU Histidine kinase AOD63_24425 ENOG4107S9D Alpha beta hydrolase AOD63_24445 ENOG4105D2X ABC transporter substrate-binding protein AOD63_24455 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AOD63_24510 ENOG4108V2W Carbonate dehydratase AOD63_24515 ENOG4105C4M (Ubiquinol oxidase) subunit I AOD63_24520 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AOD63_24565 ENOG41087YS Phage shock protein A AOD63_24600 ENOG4105BZU Histidine kinase AOD63_24605 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD63_24630 ENOG4108UGV hypoxanthine phosphoribosyltransferase AOD63_24635 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AOD63_24670 ENOG4107ZTW SNARE associated Golgi AOD63_24685 ENOG4105C19 ABC transporter AOD63_24690 ENOG41086D8 Transcriptional regulator AOD63_24740 ENOG4105C6Z Gluconate AOD63_24745 ENOG4105FDP GntR family transcriptional regulator AOD63_24765 ENOG41069H0 dihydroorotase EC 3.5.2.3 AOD63_24795 ENOG4105DTQ mandelate racemase muconate lactonizing AOD63_24805 ENOG4108IPT Naphthoate synthase AOD63_24810 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AOD63_24815 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AOD63_24820 ENOG4105E4F Isochorismate synthase AOD63_24825 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AOD63_24835 ENOG4105VEQ Cold shock protein AOD63_24860 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AOD63_24870 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AOD63_24880 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOD63_24975 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AOD63_25010 ENOG4105KT7 mgtC SapB transporter AOD63_25015 ENOG4107PBV potassium channel AOD63_25025 ENOG4107QYV phosphohexose isomerase AOD63_25035 ENOG4105WG9 Conserved Protein AOD63_25045 ENOG4105CHM Aminotransferase AOD63_25050 ENOG4108ZB6 transcriptional regulator AsnC family AOD63_25055 ENOG4105C5I Dehydrogenase AOD63_25060 ENOG4108MUZ hydrolase AOD63_25070 ENOG4105C87 Aminotransferase class I and II AOD63_25085 ENOG4105Y38 Kinase-associated protein B AOD63_25095 ENOG4107R3E Citrate transporter AOD63_25110 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AOD63_25115 ENOG4105KA0 thioesterase Superfamily protein AOD63_25135 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AOD63_25155 ENOG41069ER domain protein AOD63_25170 ENOG4105CEP NADH dehydrogenase AOD63_25200 ENOG4105EWC Purine nucleoside phosphorylase AOD63_25220 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AOD63_25245 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOD63_25250 ENOG4105C4B ABC transporter, permease AOD63_25255 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AOD63_25300 ENOG41083MR nifu domain-containing protein AOD63_25315 ENOG4108W5N phosphatidylglycerophosphatase a AOD63_25330 ENOG4105DYS nad(p)h dehydrogenase (quinone) AOD63_25335 ENOG4105D4U had-superfamily hydrolase, subfamily iia AOD63_25350 ENOG4105CBT Fructose-1,6-bisphosphatase AOD63_25370 ENOG4105MMD transcriptional regulator AOD63_25375 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AOD63_25380 ENOG4107TXC Transcriptional regulator AOD63_25385 ENOG41090T1 Membrane AOD63_25410 ENOG4105FAA peptidase M23 AOD63_25420 ENOG4105KZD Domain of unknown function (DUF1805) AOD63_25425 ENOG4107R8B 5'-nucleotidase AOD63_25450 ENOG4105DIW FeS assembly protein SUFB AOD63_25455 ENOG4108UNV SUF system FeS assembly protein, NifU family AOD63_25460 ENOG4105C9B Cysteine desulfurase AOD63_25465 ENOG4105JRK feS assembly protein SufD AOD63_25470 ENOG4105C3K feS assembly ATPase SufC AOD63_25475 ENOG4105D01 (LipO)protein AOD63_25480 ENOG4105D01 (LipO)protein AOD63_25485 ENOG4108UMI ABC transporter, permease AOD63_25520 ENOG41080E8 Transcriptional regulator, Spx MgsR family AOD63_25570 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOD63_25595 ENOG4108W8B Beta-lactamase domain protein AOD63_25600 ENOG4105C1G acyl-Coa dehydrogenase AOD63_25610 ENOG4105CHU acetyl-coa acetyltransferase AOD63_25625 ENOG4105DZ1 carboxypeptidase AOD63_25645 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AOD63_25665 ENOG4108SUT Major Facilitator Superfamily AOD63_25670 ENOG4107R7I amino acid AOD63_25680 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AOD63_25690 ENOG4107AYK membrAne AOD63_25725 ENOG4107ZTW SNARE associated Golgi AOD63_25735 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AOD63_25740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD63_25745 ENOG4105BZU Histidine kinase AOD63_25755 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AOD63_25770 ENOG4105VG1 fes assembly suf system protein AOD63_25775 ENOG4105D4Y metalloprotease AOD63_25795 ENOG4107S91 Sodium hydrogen exchanger AOD63_25800 ENOG4105NCW Trka-c domain protein AOD63_25815 ENOG4108RMU ferritin dps family protein AOD63_25830 ENOG4108URH decarboxylase AOD63_25855 ENOG4105D9N nucleoside AOD63_25860 ENOG4105D9N nucleoside AOD63_25875 ENOG4108RYK Nad-dependent epimerase dehydratase AOD63_25890 ENOG4105CV8 reductase AOD63_25895 ENOG4105F27 Major Facilitator AOD63_25900 ENOG4105KVH Transcriptional regulator AOD63_25915 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AOD63_25920 ENOG4105D4A Cell wall formation (By similarity) AOD63_25930 ENOG4105C8Q Methyl-accepting chemotaxis AOD63_25940 ENOG4105WMR Protein CrcB homolog AOD63_25945 ENOG4105WMR Protein CrcB homolog AOD63_25960 ENOG4108MK9 spermidine N(1)-acetyltransferase AOD63_25965 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AOD63_25980 ENOG4108IPW abc transporter atp-binding protein AOD63_25985 ENOG4105CM4 permease protein AOD63_26010 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AOD63_26020 ENOG4105XZU Preprotein translocase, subunit SecG AOD63_26025 ENOG41067MG lrgb family AOD63_26125 ENOG4105EFC phage portal protein HK97 family AOD63_26150 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AOD63_26160 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AOD63_26165 ENOG4105CP7 Triose-phosphate isomerase AOD63_26190 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD63_26210 ENOG41090VF Stage v sporulation protein ac AOD63_26215 ENOG4105CZ3 stage V sporulation protein ad AOD63_26230 ENOG4105H67 Protein of unknown function (DUF421) AOD63_26235 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AOD63_26240 ENOG4105KRI phosphocarrier protein (HPr AOD63_26250 ENOG4105CHW UPF0052 protein AOD63_26260 ENOG4108Z4K mutator MutT protein AOD63_26270 ENOG4105C3M thioredoxin reductase AOD63_26280 ENOG4108S4C acetyltransferase AOD63_26300 ENOG41086DT Membrane protein of unknown function AOD63_26310 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOD63_26315 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AOD63_26320 ENOG4105D7V transposase AOD63_26335 ENOG4107TXC Transcriptional regulator AOD63_26360 ENOG4105HMI Membrane AOD63_26365 ENOG4105DUM transcriptional regulator, lysR family AOD63_26375 ENOG4108WS4 fmn reductase AOD63_26390 ENOG4105BZ1 (ABC) transporter AOD63_26400 ENOG4105CN1 protease AOD63_26405 ENOG4105CRP Part of the ABC transporter FtsEX involved in AOD63_26410 ENOG4105CAK Cell division ATP-binding protein ftsE AOD63_26425 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AOD63_26430 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AOD63_26435 ENOG4105MS2 ribosomal subunit Interface protein AOD63_26440 ENOG4105VEQ Cold shock protein AOD63_26445 ENOG41081UC Inherit from COG: Competence protein AOD63_26460 ENOG4105KVH Transcriptional regulator AOD63_26475 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AOD63_26480 ENOG4108KGH TRANSCRIPTIONal AOD63_26485 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AOD63_26490 ENOG4105C6Y Udp-glucose 6-dehydrogenase AOD63_26495 ENOG4105ESV Glycosyl transferase, family 4 AOD63_26505 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOD63_26520 ENOG410901P UPF0249 protein AOD63_26525 ENOG4105F8D glycoside hydrolase family 4 AOD63_26530 ENOG4105VCP PTS System AOD63_26535 ENOG4105CK1 PTS System AOD63_26545 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AOD63_26550 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AOD63_26555 ENOG4105VCP PTS System AOD63_26565 ENOG4105VZJ PTS System AOD63_26580 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AOD63_26585 ENOG4105ECB domain protein AOD63_26590 ENOG4107RSM transcriptional regulator AOD63_26635 ENOG4105DAA L-lactate AOD63_26645 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AOD63_26655 ENOG4105E0M Sulfatase AOD63_26690 ENOG4105C94 Transporter AOD63_26695 ENOG41069ER domain protein AOD63_26720 ENOG4105KBK Zinc finger, swim domain protein AOD63_26725 ENOG4105C0D helicase AOD63_26755 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD63_26765 ENOG4107RBB ABC transporter, permease AOD63_26770 ENOG4105C19 ABC transporter AOD63_26790 ENOG4105CXY transporter AOD63_26805 ENOG4105BZU Histidine kinase AOD63_26810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD63_26815 ENOG4105CMR udp-glucose 4-epimerase AOD63_26830 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AOD63_26835 ENOG4105EY8 ABC transporter AOD63_26890 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AOD63_26905 ENOG4105FRN stage II sporulation protein AOD63_26920 ENOG4105DY9 regulatoR AOD63_26925 ENOG4108IUW ABC transporter AOD63_26945 ENOG4106778 Protein of unknown function (DUF1146) AOD63_26950 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AOD63_26955 ENOG4105C8S subunit m AOD63_26960 ENOG4105D65 subunit l AOD63_26985 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AOD63_26990 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AOD63_27000 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AOD63_27005 ENOG4105BZU Histidine kinase AOD63_27055 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AOD63_27060 ENOG41062M3 atp synthase AOD63_27090 ENOG4108YZG isomerase AOD63_27105 ENOG4108VGI doxx family AOD63_27110 ENOG4107XC4 flavin reductase domain protein, FMN-binding AOD63_27125 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AOD63_27135 ENOG4108ZXQ stage ii sporulation protein r AOD63_27140 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AOD63_27145 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AOD63_27160 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AOD63_27165 ENOG4105CBT Fructose-1,6-bisphosphatase AOD63_27170 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AOD63_27205 ENOG4105C1G acyl-Coa dehydrogenase AOD63_27210 ENOG4105C1G acyl-Coa dehydrogenase AOD63_27215 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AOD63_27225 ENOG4105DF6 Fe-S oxidoreductase AOD63_27240 ENOG4105BZU Histidine kinase AOD63_27260 ENOG4105BZU Histidine kinase AOD63_27265 ENOG4105KCT ABC transporter AOD63_27270 ENOG4108M15 ABC transporter AOD63_27275 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AOD63_27295 ENOG4105IIU Aminopeptidase AOD63_27315 ENOG4105EMN RNA polymerase sigma factor AOD63_27325 ENOG410684U Domain of unknown function (DUF1934) AOD63_27350 ENOG4105CYW agmatinase AOD63_27360 ENOG4105DXB Major Facilitator superfamily AOD63_27365 ENOG4107SWG transcriptional regulator MERR family AOD63_27370 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AOD63_27375 ENOG4105BZ4 penicillin-binding protein AOD63_27380 ENOG4108XFG YwhD family AOD63_27385 ENOG4108Z4T Peptidase M50 AOD63_27390 ENOG41069HH 4-oxalocrotonate tautomerase AOD63_27395 ENOG4105DCI Phosphohydrolase AOD63_27400 ENOG4108MES Periplasmic binding protein AOD63_27405 ENOG4105E0A ABC, transporter AOD63_27410 ENOG4105EHG Permease protein AOD63_27415 ENOG4105DQ5 transport system permease protein AOD63_27420 ENOG4105DQ5 transport system permease protein AOD63_27430 ENOG4108VCI transcription factor, rsfa family AOD63_27445 ENOG4108IJ2 phosphate acetyltransferase AOD63_27460 ENOG4108VKI Cell wall hydrolase AOD63_27490 ENOG410667J hydrolase AOD63_27495 ENOG4105VCH membrane AOD63_27505 ENOG4108TU7 Inherit from COG: (ABC) transporter AOD63_27510 ENOG4105CJ1 ABC, transporter AOD63_27515 ENOG41090WU lipolytic protein G-D-S-L family AOD63_27530 ENOG4105D6E homoserine dehydrogenase AOD63_27555 ENOG4108Y4K DNA-binding transcriptional activator AOD63_27565 ENOG4105WH1 Two component transcriptional regulator luxr family AOD63_27575 ENOG4105DWF phosphomethylpyrimidine kinase AOD63_27580 ENOG4105BZU Histidine kinase AOD63_27585 ENOG4105VCD cytoplasmic protein AOD63_27590 ENOG4105D22 carbon starvation protein AOD63_27595 ENOG4105DY9 regulatoR AOD63_27600 ENOG41079KZ Major Facilitator Superfamily AOD63_27620 ENOG4105EN6 Membrane AOD63_27625 ENOG4106YBV Methyl-accepting chemotaxis AOD63_27635 ENOG4108S4H thioesterase Superfamily protein AOD63_27645 ENOG4105JEU Glycosyl transferase, family 2 AOD63_27650 ENOG4105C5H ABC transporter AOD63_27680 ENOG4105CKK Glycosyl transferase, family 2 AOD63_27685 ENOG41067SE Tetr family transcriptional regulator AOD63_27695 ENOG4105E0X reductase AOD63_27700 ENOG4106F5Q Membrane AOD63_27715 ENOG4105DY9 regulatoR AOD63_27720 ENOG4108HRK Histidine kinase AOD63_27725 ENOG4107RGD Major Facilitator superfamily AOD63_27745 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOD63_27755 ENOG4105IW1 AmiS UreI transporter AOD63_27765 ENOG4105CMR udp-glucose 4-epimerase AOD63_27770 ENOG4108UT2 hemolysin iii AOD63_27780 ENOG4105C1J atp-dependent rna helicase AOD63_27795 ENOG4105DPN Oligoendopeptidase f AOD63_27815 ENOG4105C0H protease AOD63_27820 ENOG4105Q2H domain protein AOD63_27835 ENOG4105BZU Histidine kinase AOD63_27840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD63_27870 ENOG4105CDU Replicative dna helicase AOD63_27880 ENOG4105BZR domain protein AOD63_27885 ENOG4108XMW Membrane AOD63_27895 ENOG4108UUM single-stranded DNA-binding protein AOD63_27905 ENOG4105C3G gtp-binding protein AOD63_27910 ENOG4105VDK protein, conserved in bacteria AOD63_27915 ENOG4105D8X mechanosensitive ion channel AOD63_27920 ENOG4108ZDA Sporulation protein YyaC AOD63_27925 ENOG4105FA0 parb-like partition protein AOD63_27930 ENOG4107QJE Chromosome Partitioning Protein AOD63_27950 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AOD63_27960 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins