locus-tag class description AOD66_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AOD66_00015 ENOG410848D S4 domain protein YaaA AOD66_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOD66_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AOD66_00100 ENOG4105ZMH deoxynucleoside kinase AOD66_00110 ENOG4105GTG Isochorismatase AOD66_00120 ENOG4108Z6B deaminase AOD66_00125 ENOG4105C6E dna polymerase iii AOD66_00145 ENOG41067KS pro-sigma K processing AOD66_00180 ENOG4105CXN decarboxylase AOD66_00190 ENOG4105FA2 dna polymerase iii AOD66_00195 ENOG4105MA4 psp1 domain protein AOD66_00205 ENOG41060K3 Methyltransferase AOD66_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AOD66_00220 ENOG4105KRN Transcriptional regulator, abrb family AOD66_00230 ENOG4105F8V Hydrolase, tatD family AOD66_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AOD66_00245 ENOG4105XFA sporulation peptidase YabG AOD66_00250 ENOG4105W42 Veg protein AOD66_00265 ENOG4105DFT pur operon repressor AOD66_00270 ENOG4105KME endoribonuclease L-psp AOD66_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AOD66_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AOD66_00300 ENOG4108JA2 transcriptioN-repair coupling factor AOD66_00305 ENOG4108M14 stage v sporulation protein t AOD66_00315 ENOG4108IY2 MazG family AOD66_00320 ENOG41082I2 s4 domain protein AOD66_00325 ENOG4105VYY sporulation protein yabp AOD66_00340 ENOG41060GV RNA binding s1 domain protein AOD66_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AOD66_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase AOD66_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AOD66_00385 ENOG4105C6T cysteine synthase AOD66_00390 ENOG4105CRQ synthase (Component I) AOD66_00395 ENOG4105DDQ anthranilate synthase AOD66_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AOD66_00405 ENOG4105EEI dihydropteroate synthase AOD66_00410 ENOG4105KRF dihydroneopterin aldolase AOD66_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AOD66_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AOD66_00455 ENOG4108Z0C Uvrb UvrC protein AOD66_00470 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AOD66_00480 ENOG4105CTP PilT protein domain protein AOD66_00500 ENOG4105D7W serine acetyltransferase AOD66_00515 ENOG4105C2N RNA methyltransferase TrmH family group 3 AOD66_00520 ENOG4105M0M Tetracycline resistance protein AOD66_00525 ENOG4105QIV RNA polymerase AOD66_00540 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AOD66_00565 ENOG4107Y49 methyltransferase AOD66_00575 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AOD66_00580 ENOG4105XPM ribosomal protein AOD66_00685 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AOD66_00710 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AOD66_00720 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AOD66_00730 ENOG41067V7 50S ribosomal protein L36 AOD66_00760 ENOG4108JJB ABC transporter AOD66_00765 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AOD66_00770 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AOD66_00795 ENOG4105D1F ATP-binding protein AOD66_00810 ENOG4108NMV polysaccharide deacetylase AOD66_00895 ENOG4105C8B TIGR00159 family AOD66_00900 ENOG4107U5W ybbr family AOD66_00915 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AOD66_00920 ENOG4108VQT Alpha beta hydrolase fold protein AOD66_00940 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AOD66_00945 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AOD66_00980 ENOG4108PSK reductase AOD66_00985 ENOG4108UMI ABC transporter, permease AOD66_00990 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOD66_00995 ENOG4105D01 (LipO)protein AOD66_01000 ENOG4105EE1 crotonyl-CoA reductase AOD66_01010 ENOG4105IQ5 FAD linked oxidase domain protein AOD66_01025 ENOG4105C2C drug resistance transporter, Bcr CflA AOD66_01040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOD66_01045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD66_01050 ENOG4105C3U ABC transporter AOD66_01055 ENOG4108JQ7 (ABC) transporter AOD66_01085 ENOG4108J59 Extracellular solute-binding protein, family 5 AOD66_01090 ENOG4108J59 Extracellular solute-binding protein, family 5 AOD66_01100 ENOG4105II7 pyrroline-5-carboxylate reductase AOD66_01110 ENOG4107XDY Nicotinamide Mononucleotide Transporter AOD66_01120 ENOG4105E0C molybdate abc transporter AOD66_01125 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOD66_01130 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOD66_01135 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AOD66_01150 ENOG4105EGI Transcriptional regulator AOD66_01165 ENOG4105F6E Acyl-transferase AOD66_01185 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AOD66_01200 ENOG4108RE7 deoxyribonuclease AOD66_01205 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AOD66_01230 ENOG4105C5H ABC transporter AOD66_01245 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AOD66_01255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD66_01260 ENOG4105C3U ABC transporter AOD66_01265 ENOG4108JQ7 (ABC) transporter AOD66_01290 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AOD66_01295 ENOG4105ERH Fumarylacetoacetate hydrolase AOD66_01305 ENOG4108SC4 )-transporter AOD66_01310 ENOG4105CPF Cell wall formation (By similarity) AOD66_01315 ENOG4105CPF Cell wall formation (By similarity) AOD66_01320 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AOD66_01335 ENOG4107ZXI Rhomboid family AOD66_01345 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AOD66_01350 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AOD66_01360 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AOD66_01460 ENOG4105K8N protein family UPF0079, ATPase AOD66_01465 ENOG41072GX Peptidase M22 Glycoprotease AOD66_01470 ENOG410801F ribosomal-protein-alanine acetyltransferase AOD66_01475 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AOD66_01480 ENOG4105C5H ABC transporter AOD66_01495 ENOG4108TYN CAAX amino terminal protease family protein AOD66_01515 ENOG4105C7N Xanthine uracil vitamin C permease AOD66_01525 ENOG4105BZU Histidine kinase AOD66_01555 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOD66_01595 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOD66_01615 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD66_01635 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AOD66_01640 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AOD66_01645 ENOG4105C83 adenylosuccinate lyase AOD66_01655 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AOD66_01680 ENOG4108V3E phosphoribosylglycinamide formyltransferase AOD66_01690 ENOG4105C12 Phosphoribosylglycinamide synthetase AOD66_01715 ENOG4105C4R Atp-dependent dna helicase AOD66_01745 ENOG4108W2Y isochorismatase AOD66_01750 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOD66_01755 ENOG4108UMI ABC transporter, permease AOD66_01760 ENOG4105D01 (LipO)protein AOD66_01780 ENOG410834F Transcriptional regulator AOD66_01805 ENOG4105CBD Diacylglycerol kinase AOD66_01810 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AOD66_01815 ENOG4108JPW Aminotransferase AOD66_01825 ENOG4105C26 Dehydrogenase AOD66_01830 ENOG4105KPY Small multidrug resistance protein AOD66_01850 ENOG4105D9N nucleoside AOD66_01855 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AOD66_01870 ENOG4108W15 Protein of unknown function (DUF1456) AOD66_01885 ENOG4105DTQ mandelate racemase muconate lactonizing AOD66_01895 ENOG4105DFD Na H antiporter AOD66_01915 ENOG4105D3R alkyl hydroperoxide reductase AOD66_01920 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AOD66_01930 ENOG4107W7X Aldolase AOD66_01935 ENOG4105EHG Permease protein AOD66_01940 ENOG4105DQ5 transport system permease protein AOD66_01945 ENOG4108V5C ABC transporter AOD66_01970 ENOG4106UIA AOD66_01975 ENOG4106UIA AOD66_02000 ENOG4105BZU Histidine kinase AOD66_02020 ENOG410756H nucleotidyltransferase AOD66_02025 ENOG4105D2S major facilitator superfamily AOD66_02040 ENOG4105E5Q amino acid AbC transporter AOD66_02045 ENOG4105EAB amino acid AbC transporter AOD66_02060 ENOG4105C8Q Methyl-accepting chemotaxis AOD66_02065 ENOG4105C8Q Methyl-accepting chemotaxis AOD66_02075 ENOG4105CI1 PTS System AOD66_02105 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AOD66_02120 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AOD66_02135 ENOG4105C5H ABC transporter AOD66_02160 ENOG41062JF Transcriptional regulator AOD66_02180 ENOG4105DEU major facilitator superfamily AOD66_02195 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) AOD66_02210 ENOG4108N0M stress protein AOD66_02215 ENOG4106FN3 tellurium resistance protein AOD66_02220 ENOG4106FN3 tellurium resistance protein AOD66_02225 ENOG4107TS3 membrane protein, TerC AOD66_02230 ENOG4108TTB tellurium resistance protein AOD66_02250 ENOG4105KJF protein tyrosine phosphatase AOD66_02260 ENOG4107U9T Pfam:Ribonuclease_BN AOD66_02265 ENOG4105C59 p-type ATPase AOD66_02270 ENOG4108IPJ Membrane AOD66_02290 ENOG4107ZTW SNARE associated Golgi AOD66_02305 ENOG410606W general stress protein AOD66_02310 ENOG4105UPD Calcium Proton AOD66_02350 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AOD66_02355 ENOG4105VTR Integrase AOD66_02360 ENOG4108IMY Transcriptional regulator AOD66_02635 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AOD66_02645 ENOG4108JUB Transcriptional regulator AOD66_02655 ENOG4108IQI permease AOD66_02690 ENOG4105CSV Glutaminase AOD66_02700 ENOG4108A04 Beta-lactamase AOD66_02715 ENOG4105CKK Glycosyl transferase, family 2 AOD66_02725 ENOG4107QQG Dehydrogenase AOD66_02730 ENOG4105C3I Nad-dependent epimerase dehydratase AOD66_02750 ENOG4105F1A Pyruvate formate-lyase AOD66_02770 ENOG4105CI2 imidazolone-5-propionate hydrolase AOD66_02775 ENOG4105ECP epimerase AOD66_02805 ENOG41067AE Membrane-bound metal-dependent hydrolase AOD66_02810 ENOG4105CEN a g-specific adenine glycosylase AOD66_02815 ENOG4106BXE AOD66_02835 ENOG4105BZ1 (ABC) transporter AOD66_02840 ENOG4107NBY Membrane AOD66_02845 ENOG4105CBC glutamate synthase AOD66_02855 ENOG4108IUW ABC transporter AOD66_02875 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AOD66_02880 ENOG4105G5W regulator Fur family AOD66_02995 ENOG4108JQC penicillin-binding protein 1A AOD66_03000 ENOG4107ZQN disulfide bond AOD66_03010 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AOD66_03020 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AOD66_03025 ENOG4105BZU Histidine kinase AOD66_03035 ENOG4105CYN Serine protein kinase AOD66_03060 ENOG4105C94 Transporter AOD66_03075 ENOG4105DZ6 Band 7 protein AOD66_03085 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AOD66_03095 ENOG4105D4T Citrate transporter AOD66_03115 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AOD66_03120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOD66_03125 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AOD66_03130 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AOD66_03135 ENOG4105BZ7 extracellular solute-binding protein family 1 AOD66_03140 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AOD66_03145 ENOG4108STX response regulator AOD66_03150 ENOG4105US7 Histidine kinase AOD66_03175 ENOG4108MRH transcriptional regulatory protein AOD66_03185 ENOG4105C6K Malic enzyme AOD66_03195 ENOG4108UZ3 Transporter AOD66_03200 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AOD66_03210 ENOG4105BZU Histidine kinase AOD66_03215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD66_03225 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AOD66_03230 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AOD66_03235 ENOG4108JB9 formate dehydrogenase AOD66_03255 ENOG4105CUB amino acid AOD66_03265 ENOG4105C59 p-type ATPase AOD66_03270 ENOG4105DAP Nicotinate phosphoribosyltransferase AOD66_03300 ENOG41073R8 VanW family AOD66_03305 ENOG4108KGH TRANSCRIPTIONal AOD66_03310 ENOG4105D9N nucleoside AOD66_03315 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AOD66_03320 ENOG4105C37 (CBS) domain AOD66_03325 ENOG4108IJ0 Aspartate ammonia-lyase AOD66_03330 ENOG4105DAA L-lactate AOD66_03345 ENOG4105DUX Transporter AOD66_03350 ENOG4108MES Periplasmic binding protein AOD66_03355 ENOG4105DQ5 transport system permease protein AOD66_03360 ENOG4108IHU transport system permease protein AOD66_03365 ENOG4105E0A ABC, transporter AOD66_03370 ENOG4105DMQ Methyltransferase AOD66_03390 ENOG4107T89 von Willebrand factor, type A AOD66_03395 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AOD66_03400 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOD66_03415 ENOG4105BZU Histidine kinase AOD66_03420 ENOG4105D5Q Arginine ornithine antiporter AOD66_03425 ENOG4107414 GntR family transcriptional regulator AOD66_03430 ENOG4105C5Y PTS System AOD66_03435 ENOG4105CG3 alpha amylase, catalytic region AOD66_03450 ENOG4105E1K spore germination protein AOD66_03460 ENOG4105CRN Aminoglycoside phosphotransferase AOD66_03465 ENOG4105BZG amino acid carrier protein AOD66_03470 ENOG4105CDA abc transporter atp-binding protein AOD66_03475 ENOG4105CT1 (ABC) transporter AOD66_03480 ENOG4105EAD ABC transporter AOD66_03485 ENOG4105DRP amino acid AbC transporter AOD66_03490 ENOG4108IQI permease AOD66_03515 ENOG4105D29 Helix-turn-helix type 11 domain protein AOD66_03520 ENOG4105NAE bifunctional deaminase-reductase domain protein AOD66_03525 ENOG4105BZU Histidine kinase AOD66_03540 ENOG4105CHH sulfate transporter AOD66_03545 ENOG41068KF Universal stress protein AOD66_03555 ENOG4105DEF Extracellular solute-binding protein, family 5 AOD66_03565 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOD66_03570 ENOG4108JQ7 (ABC) transporter AOD66_03575 ENOG4105C3U ABC transporter AOD66_03580 ENOG4105CXY transporter AOD66_03585 ENOG41067TZ transcriptional regulator, MarR family AOD66_03590 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD66_03595 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD66_03600 ENOG4105ETE Transcriptional regulator (LacI family AOD66_03605 ENOG4108RVA ribokinase AOD66_03615 ENOG4105C2J ABC transporter AOD66_03620 ENOG4105CNN ABC, transporter AOD66_03625 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AOD66_03630 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AOD66_03690 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOD66_03695 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AOD66_03700 ENOG41069ER domain protein AOD66_03705 ENOG4105VZ8 Transcriptional regulator AOD66_03710 ENOG4107D63 AOD66_03720 ENOG4105DUX Transporter AOD66_03740 ENOG4105C85 amino acid AOD66_03745 ENOG4105C7N Xanthine uracil vitamin C permease AOD66_03785 ENOG4105BZ9 Cytochrome C oxidase, subunit I AOD66_03790 ENOG4105E2S oxidase) subunit II AOD66_03795 ENOG4108IQI permease AOD66_03810 ENOG4106CAD Protein of unknown function (DUF3311) AOD66_03815 ENOG4105E1V na solute symporter AOD66_03830 ENOG4108NHD germination protein AOD66_03840 ENOG4105CE1 Ferrous iron transport protein b AOD66_03845 ENOG4105CE1 Ferrous iron transport protein b AOD66_03850 ENOG4105CE1 Ferrous iron transport protein b AOD66_03855 ENOG4105CVA phosphate AOD66_03860 ENOG4105C8U phosphate abc transporter AOD66_03865 ENOG4105E2Z phosphate ABC transporter (Permease AOD66_03990 ENOG41080XQ Signal transduction protein with cbs domains AOD66_04015 ENOG4105ETU transcriptional activator (TenA AOD66_04025 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AOD66_04035 ENOG4108VEU Thiamine monophosphate synthase AOD66_04040 ENOG41080HI glycine oxidase AOD66_04055 ENOG4105D06 uba thif-type nad fad binding protein AOD66_04060 ENOG4105DWF phosphomethylpyrimidine kinase AOD66_04105 ENOG4108INS Transcriptional regulator AOD66_04120 ENOG4105C7N Xanthine uracil vitamin C permease AOD66_04150 ENOG4105C5Y PTS System AOD66_04210 ENOG4107Y03 Nitroreductase AOD66_04215 ENOG4105ED1 spovr family AOD66_04240 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AOD66_04245 ENOG4105XTG Pfam:DUF156 AOD66_04250 ENOG4105VFE sira family AOD66_04255 ENOG4107TPS domain protein AOD66_04260 ENOG4105VFE sira family AOD66_04265 ENOG41085GJ domain protein AOD66_04275 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AOD66_04280 ENOG41087NI Sulfite exporter TauE/SafE AOD66_04290 ENOG4108KGH TRANSCRIPTIONal AOD66_04315 ENOG4105EMD TRANSCRIPTIONal AOD66_04320 ENOG4105VCP PTS System AOD66_04325 ENOG4105VZJ PTS System AOD66_04345 ENOG41069ER domain protein AOD66_04350 ENOG4107RBB ABC transporter, permease AOD66_04355 ENOG4105C19 ABC transporter AOD66_04385 ENOG4105WEF catalase AOD66_04420 ENOG4107T5V SNARE associated Golgi AOD66_04455 ENOG4105CUB amino acid AOD66_04460 ENOG4107RWR Sodium hydrogen exchanger AOD66_04470 ENOG4106KNT transcriptional regulator AOD66_04505 ENOG4108PCN EamA-like transporter family AOD66_04510 ENOG4108YXU transcriptional regulator AsnC family AOD66_04520 ENOG4105KPY Small multidrug resistance protein AOD66_04525 ENOG4105KPY Small multidrug resistance protein AOD66_04550 ENOG4105NF4 modulator of drug activity AOD66_04555 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AOD66_04560 ENOG4105E5W Transporter AOD66_04570 ENOG4107RKG DJ-1/PfpI family AOD66_04575 ENOG4105CH6 catalase AOD66_04585 ENOG4105D5Q Arginine ornithine antiporter AOD66_04590 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AOD66_04600 ENOG4105C26 Dehydrogenase AOD66_04610 ENOG4105BZ1 (ABC) transporter AOD66_04625 ENOG4105DRP amino acid AbC transporter AOD66_04630 ENOG4105CDA abc transporter atp-binding protein AOD66_04645 ENOG410839P AOD66_04680 ENOG4107FQX Alpha-acetolactate decarboxylase AOD66_04710 ENOG4105D4P Coproporphyrinogen iii oxidase AOD66_04725 ENOG4105CHH sulfate transporter AOD66_04765 ENOG4106AKK s-layer domain-containing protein AOD66_04775 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOD66_04780 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOD66_04795 ENOG4105CGU Enoyl-CoA hydratase AOD66_04815 ENOG4105DER m42 family AOD66_04835 ENOG4105CTU Proline racemase AOD66_04880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD66_04890 ENOG4108JQ7 (ABC) transporter AOD66_04920 ENOG4105CSH Transporter AOD66_04930 ENOG4108MRH transcriptional regulatory protein AOD66_04980 ENOG4105CDU Replicative dna helicase AOD66_05020 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD66_05070 ENOG4107P5I polyketide synthase AOD66_05075 ENOG4108IG5 Transcriptional regulator AOD66_05095 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AOD66_05115 ENOG4105CMT Dihydroxyacetone kinase AOD66_05130 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AOD66_05135 ENOG410847I Transcriptional regulator, BadM Rrf2 family AOD66_05160 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AOD66_05225 ENOG4105WN5 stage II sporulation protein AOD66_05235 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD66_05245 ENOG4108MJI response regulator AOD66_05250 ENOG4105BZU Histidine kinase AOD66_05255 ENOG4105BZU Histidine kinase AOD66_05280 ENOG4105K8R UPF0145 protein AOD66_05315 ENOG4107VRP DNA repair exonuclease AOD66_05320 ENOG4106D4I domain protein AOD66_05325 ENOG4105D7V transposase AOD66_05340 ENOG4108IND Tetr family transcriptional regulator AOD66_05345 ENOG4105EQ0 Major Facilitator superfamily AOD66_05365 ENOG4108MUZ hydrolase AOD66_05385 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AOD66_05400 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AOD66_05415 ENOG4105EMN RNA polymerase sigma factor AOD66_05440 ENOG4105C57 major facilitator superfamily AOD66_05445 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD66_05455 ENOG4105EEM helicase AOD66_05460 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOD66_05490 ENOG4105K59 histidine triad (HIT) protein AOD66_05520 ENOG410905X membrane-flanked domain protein AOD66_05530 ENOG4105CKV Membrane AOD66_05570 ENOG410905X membrane-flanked domain protein AOD66_05575 ENOG4105CKV Membrane AOD66_05580 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AOD66_05585 ENOG4105BZ4 penicillin-binding protein AOD66_05590 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AOD66_05600 ENOG4105C1Q protoporphyrinogen oxidase AOD66_05625 ENOG4105NA0 Transcriptional regulator AOD66_05640 ENOG4105ECB domain protein AOD66_05670 ENOG4106AXD AOD66_05675 ENOG4108RQ5 Beta-lactamase domain-containing protein AOD66_05680 ENOG4105DF9 Lipoate-protein, ligase AOD66_05690 ENOG4105CEY Amp-dependent synthetase and ligase AOD66_05720 ENOG4105CNA YD repeat protein AOD66_05755 ENOG4105ENX hydrolase AOD66_05765 ENOG4107RN3 metallophosphoesterase AOD66_05770 ENOG4107TVP HD domain protein AOD66_05780 ENOG4108AEY RNA polymerase sigma factor AOD66_05785 ENOG41086D8 Transcriptional regulator AOD66_05805 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD66_05830 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AOD66_05835 ENOG4105C8Q Methyl-accepting chemotaxis AOD66_05855 ENOG4105ZU5 s-layer protein AOD66_05860 ENOG4107QP3 malate synthase g AOD66_05875 ENOG4105VEQ Cold shock protein AOD66_05890 ENOG4105XVF Competence transcription factor AOD66_05905 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AOD66_05910 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AOD66_05955 ENOG4105ERH Fumarylacetoacetate hydrolase AOD66_05980 ENOG4105CAQ asparagine synthetase AOD66_05985 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AOD66_05990 ENOG4105CH6 catalase AOD66_05995 ENOG4105BZU Histidine kinase AOD66_06020 ENOG4105QNR S1 RNA binding domain protein AOD66_06030 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOD66_06040 ENOG4107AYK membrAne AOD66_06045 ENOG41073B9 AOD66_06055 ENOG4108KP7 hydrolase AOD66_06070 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AOD66_06095 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOD66_06100 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AOD66_06115 ENOG4105C31 Tryptophanyl-tRNA synthetase AOD66_06130 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOD66_06135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD66_06145 ENOG4108JQ7 (ABC) transporter AOD66_06150 ENOG4105UQX Mate efflux family protein AOD66_06175 ENOG4108ZCF integral membrane protein AOD66_06185 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOD66_06195 ENOG4105DPN Oligoendopeptidase f AOD66_06210 ENOG4108Z18 K06886 hemoglobin AOD66_06215 ENOG4105MIX Adenylate cyclase AOD66_06230 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AOD66_06235 ENOG4105EMS pseudouridine synthase AOD66_06255 ENOG4105K64 Glycosyl transferase, family 2 AOD66_06275 ENOG4107TVC Glycosyl transferase, family 2 AOD66_06295 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AOD66_06300 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AOD66_06310 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AOD66_06360 ENOG4108WVJ 2'-5' rna ligase AOD66_06385 ENOG4105CK7 Sodium proline symporter AOD66_06395 ENOG4105CRQ synthase (Component I) AOD66_06400 ENOG4105DDQ anthranilate synthase AOD66_06490 ENOG4105C7S Dehydrogenase AOD66_06500 ENOG4105VZ8 Transcriptional regulator AOD66_06560 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AOD66_06570 ENOG4105DZ1 carboxypeptidase AOD66_06575 ENOG4105VFR signal peptidase AOD66_06610 ENOG4105C26 Dehydrogenase AOD66_06615 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOD66_06620 ENOG4105F38 ABC transporter, permease AOD66_06625 ENOG4105D38 putrescine abc transporter AOD66_06630 ENOG4107RUE extracellular solute-binding protein family 1 AOD66_06640 ENOG4105EYF MMPL domain protein AOD66_06650 ENOG4108YBP pseudouridine synthase AOD66_06660 ENOG4105K4I Scp-like extracellular AOD66_06665 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AOD66_06670 ENOG4105CQB FAD linked oxidase domain protein AOD66_06685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD66_06690 ENOG4105BZU Histidine kinase AOD66_06695 ENOG4105JXH GntR family transcriptional regulator AOD66_06715 ENOG4106A3R peptidase AOD66_06725 ENOG4108QTI )-transporter AOD66_06730 ENOG4107TS3 membrane protein, TerC AOD66_06735 ENOG4105CZN Potassium uptake protein AOD66_06740 ENOG410681C small acid-soluble spore protein AOD66_06745 ENOG4108Z7G MaoC domain protein dehydratase AOD66_06765 ENOG4105CHR reductase AOD66_06775 ENOG4105MWK D-amino acid dehydrogenase, small subunit AOD66_06795 ENOG4105C4Y ABC transporter AOD66_06810 ENOG4107RCV ABC transporter, permease AOD66_06815 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AOD66_06830 ENOG4105E98 transcriptional regulator DeoR family AOD66_06855 ENOG4105PXI polysaccharide deacetylase AOD66_06865 ENOG4105BZU Histidine kinase AOD66_06870 ENOG41090MY MarR family Transcriptional regulator AOD66_06880 ENOG4106DF1 AOD66_06890 ENOG4105BZU Histidine kinase AOD66_06900 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AOD66_06905 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AOD66_06950 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AOD66_06970 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AOD66_06975 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AOD66_06980 ENOG4105CZV ABC transporter AOD66_06990 ENOG4105CJ1 ABC, transporter AOD66_07030 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AOD66_07035 ENOG4105EA8 2-Nitropropane dioxygenase AOD66_07040 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AOD66_07050 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOD66_07075 ENOG4105NQC Flavodoxin AOD66_07110 ENOG4107QMU Mate efflux family protein AOD66_07115 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOD66_07145 ENOG4105CZN Potassium uptake protein AOD66_07150 ENOG41063Y9 AOD66_07155 ENOG4105KBJ sporulation protein ytfj AOD66_07185 ENOG4105CM2 brancheD-chain amino acid aminotransferase AOD66_07190 ENOG4105C7K acetolactate synthase AOD66_07195 ENOG4108ZP8 Acetolactate synthase small subunit AOD66_07200 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AOD66_07210 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AOD66_07235 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AOD66_07270 ENOG4107RVV histidinol phosphate phosphatase, hisj family AOD66_07285 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AOD66_07290 ENOG4105E0M Sulfatase AOD66_07300 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AOD66_07320 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AOD66_07325 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AOD66_07335 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AOD66_07340 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AOD66_07345 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AOD66_07355 ENOG4105C8J )-transporter AOD66_07375 ENOG4105DFD Na H antiporter AOD66_07395 ENOG4105ENE Histidine kinase AOD66_07400 ENOG4105WH1 Two component transcriptional regulator luxr family AOD66_07420 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AOD66_07445 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AOD66_07470 ENOG4105CJ3 phosphate transporter AOD66_07475 ENOG4107GRR phosphate transport regulator AOD66_07480 ENOG4105BZ4 penicillin-binding protein AOD66_07495 ENOG4105BZU Histidine kinase AOD66_07500 ENOG4105I3N Conserved Protein AOD66_07515 ENOG4105BZU Histidine kinase AOD66_07550 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOD66_07555 ENOG4105DZ1 carboxypeptidase AOD66_07560 ENOG4108JIC nucleoside recognition domain protein AOD66_07570 ENOG4105FE9 pseudouridine synthase AOD66_07580 ENOG4107TWT Cytochrome c biogenesis protein AOD66_07585 ENOG4105CRE cytochrome C AOD66_07590 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD66_07595 ENOG4105BZU Histidine kinase AOD66_07600 ENOG4108WBT adenosyltransferase AOD66_07615 ENOG4108SAX Membrane AOD66_07625 ENOG4105T7X AOD66_07630 ENOG4105C9U ATP-dependent DNA helicase RecQ AOD66_07635 ENOG4105I7S Abortive infection protein AOD66_07650 ENOG4107X2D transcriptional regulator, merr family AOD66_07655 ENOG4108S6Z Negative regulator of genetic competence AOD66_07680 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AOD66_07685 ENOG4107RB3 L-asparaginase AOD66_07720 ENOG4105S2F AOD66_07725 ENOG41065D1 AOD66_07755 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AOD66_07770 ENOG4105XXQ heptaprenyl diphosphate synthase component I AOD66_07780 ENOG4105EAH synthase AOD66_07800 ENOG4105CIH Imidazole acetol-phosphate transaminase AOD66_07805 ENOG41068YB TPR repeat-containing protein AOD66_07820 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AOD66_07825 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AOD66_07830 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AOD66_07860 ENOG4108JYZ YitT family AOD66_07865 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AOD66_07880 ENOG4105FJR Lmbe family AOD66_07885 ENOG4105CPK Glycosyl transferase (Group 1 AOD66_07925 ENOG4105DVT helicase AOD66_07930 ENOG4105YAC AOD66_07950 ENOG4105CSM endonuclease III AOD66_07960 ENOG4105BZ4 penicillin-binding protein AOD66_08010 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AOD66_08020 ENOG4105DVT helicase AOD66_08025 ENOG4105CTD carboxy-peptidase AOD66_08040 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AOD66_08050 ENOG4105C2W permease AOD66_08055 ENOG4105DHF Membrane AOD66_08060 ENOG410890F Dynamin family AOD66_08070 ENOG4108W0I acetyltransferase AOD66_08080 ENOG4105KHC sulfurtransferase AOD66_08095 ENOG4106032 Glutathionylspermidine synthase AOD66_08155 ENOG4105CPK Glycosyl transferase (Group 1 AOD66_08170 ENOG4108SZE gCN5-related N-acetyltransferase AOD66_08190 ENOG41081VK Ribonuclease AOD66_08255 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOD66_08265 ENOG4107RWR Sodium hydrogen exchanger AOD66_08270 ENOG4105CN5 Metallo-Beta-Lactamase AOD66_08275 ENOG4108Z5V transcriptional regulator, merr family AOD66_08285 ENOG4105H67 Protein of unknown function (DUF421) AOD66_08290 ENOG41080C8 DUF218 domain AOD66_08345 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AOD66_08355 ENOG4107R0U MotA TolQ exbB proton channel AOD66_08360 ENOG4105ER2 Ompa motb domain protein AOD66_08365 ENOG4107YTP response regulator receiver protein AOD66_08375 ENOG4105DD5 Flagellar motor switch protein AOD66_08390 ENOG4105BZU Histidine kinase AOD66_08410 ENOG4105E1Q flagellar hook-associated protein AOD66_08415 ENOG4105DTJ flagellar hook-associated protein AOD66_08440 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AOD66_08445 ENOG4108ZC9 flagellar basal-body rod protein flgc AOD66_08450 ENOG41075Z6 flagellar hook-basal body complex protein fliE AOD66_08455 ENOG4107U2N Flagellar M-ring protein AOD66_08465 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AOD66_08500 ENOG4105BZE flagellar hook protein, FlgE AOD66_08525 ENOG4105K64 Glycosyl transferase, family 2 AOD66_08555 ENOG4107TVC Glycosyl transferase, family 2 AOD66_08580 ENOG4105I03 Flagellin AOD66_08585 ENOG4105E4C Lytic transglycosylase catalytic AOD66_08600 ENOG4105DD5 Flagellar motor switch protein AOD66_08610 ENOG4105CN7 Flagellar biosynthetic protein FliP AOD66_08615 ENOG4105VS8 Flagellar biosynthetic protein fliq AOD66_08625 ENOG4105D00 flagellar biosynthetic protein flhB AOD66_08630 ENOG4105D7B Flagellar biosynthesis protein flha AOD66_08640 ENOG4105KTQ flagellar basal-body rod protein AOD66_08645 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOD66_08670 ENOG4108RZE Tetr family transcriptional regulator AOD66_08690 ENOG4105KAC Antibiotic biosynthesis monooxygenase AOD66_08715 ENOG4105DUM transcriptional regulator, lysR family AOD66_08720 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOD66_08725 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOD66_08730 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AOD66_08735 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AOD66_08770 ENOG4105CVJ phosphoglycerate mutase AOD66_08800 ENOG4105CAQ asparagine synthetase AOD66_08820 ENOG4105PGM cation diffusion facilitator family transporter AOD66_08830 ENOG4105DRR Transcriptional regulator, GntR family AOD66_08835 ENOG4108UZ3 Transporter AOD66_08840 ENOG4105CKI cobalamin synthesis protein AOD66_08845 ENOG4108PJD permease AOD66_08860 ENOG4105DFD Na H antiporter AOD66_08865 ENOG4105C9Q fumarate hydratase class II AOD66_08895 ENOG4105EC3 peptidase S51, dipeptidase E AOD66_08915 ENOG4107QIV Cytochrome c biogenesis protein AOD66_08950 ENOG4106BRA Membrane AOD66_08985 ENOG4105CJ1 ABC, transporter AOD66_09005 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AOD66_09015 ENOG4108IJ0 Aspartate ammonia-lyase AOD66_09020 ENOG4105C6K Malic enzyme AOD66_09090 ENOG4105FVX AOD66_09130 ENOG4105CSR polyphosphate kinase 2 AOD66_09150 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AOD66_09165 ENOG4105EU0 Major facilitator Superfamily AOD66_09170 ENOG4105C6T cysteine synthase AOD66_09190 ENOG4105C8J )-transporter AOD66_09200 ENOG4105X5K response regulator receiver protein AOD66_09205 ENOG4105H67 Protein of unknown function (DUF421) AOD66_09220 ENOG4106KE4 Dehydrogenase AOD66_09235 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AOD66_09240 ENOG4105CHR reductase AOD66_09245 ENOG4105CM2 brancheD-chain amino acid aminotransferase AOD66_09250 ENOG4105C7K acetolactate synthase AOD66_09255 ENOG4108ZP8 Acetolactate synthase small subunit AOD66_09260 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AOD66_09270 ENOG4105C7B Threonine dehydratase AOD66_09295 ENOG4105C6X Major Facilitator AOD66_09300 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AOD66_09310 ENOG4105DY9 regulatoR AOD66_09315 ENOG4105CYC Transferase AOD66_09335 ENOG4105F6J Alpha beta hydrolase fold AOD66_09340 ENOG4108J59 Extracellular solute-binding protein, family 5 AOD66_09370 ENOG41068WN AOD66_09390 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AOD66_09395 ENOG4105C72 UPF0176 protein AOD66_09405 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AOD66_09440 ENOG4107RHR regulatoR AOD66_09450 ENOG4105D9N nucleoside AOD66_09455 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AOD66_09490 ENOG4107RAQ aminopeptidase AOD66_09495 ENOG4107STQ Multicopper oxidase AOD66_09540 ENOG4108T5E Copper resistance protein AOD66_09545 ENOG4105KTB nuclear export factor GLE1 AOD66_09555 ENOG4107RT3 EamA-like transporter family AOD66_09560 ENOG4105GZI Transcriptional regulator AOD66_09565 ENOG4108Z40 Transcriptional regulator AOD66_09570 ENOG4107ZXU DSBA oxidoreductase AOD66_09575 ENOG4108TVJ Nitroreductase AOD66_09585 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AOD66_09590 ENOG4106F5Q Membrane AOD66_09595 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOD66_09605 ENOG4105CKI cobalamin synthesis protein AOD66_09625 ENOG4108Z7G MaoC domain protein dehydratase AOD66_09630 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOD66_09640 ENOG4105C0Z ABC transporter AOD66_09645 ENOG4108IV0 ABC, transporter AOD66_09650 ENOG4105C32 Amino acid ABC transporter (Permease) AOD66_09660 ENOG4105SKE transcriptional Regulator LysR family AOD66_09680 ENOG4105YGB Transcriptional regulator AOD66_09690 ENOG4105C4M (Ubiquinol oxidase) subunit I AOD66_09695 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AOD66_09700 ENOG4108JJ9 ABC, transporter AOD66_09705 ENOG4108JJ8 (ABC) transporter AOD66_09750 ENOG4105BZ1 (ABC) transporter AOD66_09755 ENOG4105BZ1 (ABC) transporter AOD66_09760 ENOG4105EFI regulatoR AOD66_09765 ENOG4105BZU Histidine kinase AOD66_09785 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AOD66_09790 ENOG4108ZJ4 polysaccharide deacetylase AOD66_09810 ENOG4105D6E homoserine dehydrogenase AOD66_09835 ENOG4108KGH TRANSCRIPTIONal AOD66_09845 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD66_09850 ENOG4105BZU Histidine kinase AOD66_09855 ENOG4107VMI polysaccharide deacetylase AOD66_09865 ENOG4105KT7 mgtC SapB transporter AOD66_09870 ENOG4105VRR gCN5-related N-acetyltransferase AOD66_09880 ENOG4105DUU IucA IucC family protein AOD66_09885 ENOG4105CEY Amp-dependent synthetase and ligase AOD66_09900 ENOG4108WBH protein TIM barrel AOD66_09905 ENOG4105YWU small acid-soluble spore protein AOD66_09915 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AOD66_09965 ENOG4105KRN Transcriptional regulator, abrb family AOD66_09975 ENOG4105YVS arsR family transcriptional regulator AOD66_09980 ENOG4107SET aldo keto reductase AOD66_09985 ENOG4107XZQ multidrug resistance protein AOD66_10010 ENOG4105C8Q Methyl-accepting chemotaxis AOD66_10030 ENOG4108K88 Membrane AOD66_10035 ENOG4108WPJ Ferritin-like domain AOD66_10050 ENOG4105DEN Luciferase family AOD66_10070 ENOG4107QM2 Aldo Keto reductase AOD66_10075 ENOG4105CKI cobalamin synthesis protein AOD66_10140 ENOG4105DSE periplasmic solute binding protein AOD66_10150 ENOG4105K4T epimerase AOD66_10160 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AOD66_10185 ENOG4105CVJ phosphoglycerate mutase AOD66_10205 ENOG4107T5V SNARE associated Golgi AOD66_10220 ENOG4108PJD permease AOD66_10230 ENOG4108S4H thioesterase Superfamily protein AOD66_10235 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOD66_10255 ENOG4105SXS Protein of unknown function (DUF456) AOD66_10260 ENOG4105C37 (CBS) domain AOD66_10280 ENOG4108Z7R Chaperone CsaA AOD66_10300 ENOG4108ZRV stage ii sporulation protein p AOD66_10310 ENOG4108VXD carboxy-peptidase AOD66_10320 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AOD66_10345 ENOG4108X4Q Hydrolase AOD66_10355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AOD66_10360 ENOG4107RBS Methyltransferase AOD66_10375 ENOG41087PP glycosyltransferase MGT family AOD66_10380 ENOG4108JYZ YitT family AOD66_10385 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AOD66_10410 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AOD66_10460 ENOG4105KBJ sporulation protein ytfj AOD66_10485 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AOD66_10505 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AOD66_10510 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase AOD66_10520 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AOD66_10525 ENOG4105EMN RNA polymerase sigma factor AOD66_10550 ENOG4108V06 Glutathione peroxidase AOD66_10565 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOD66_10585 ENOG4108IUE nitrate reductase beta subunit AOD66_10590 ENOG4105R3A Nitrate reductase AOD66_10615 ENOG4107V6Q Cyclic nucleotide-binding domain AOD66_10620 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AOD66_10625 ENOG4105D06 uba thif-type nad fad binding protein AOD66_10630 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOD66_10635 ENOG4108ZAF Molybdopterin AOD66_10660 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AOD66_10665 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AOD66_10670 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AOD66_10675 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AOD66_10680 ENOG4108IFG nitrite reductase, (NAD(P)H) AOD66_10685 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AOD66_10720 ENOG4105MCT stage V sporulation protein S AOD66_10735 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AOD66_10755 ENOG4105C5H ABC transporter AOD66_10770 ENOG4108UUM single-stranded DNA-binding protein AOD66_10785 ENOG41061H0 Monooxygenase AOD66_10805 ENOG4107YX5 Pfam:DUF548 AOD66_10810 ENOG4105C75 arginyL-tRNA synthetase AOD66_10835 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AOD66_10850 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AOD66_10855 ENOG4105C5S asparaginyl-tRNA synthetase AOD66_10875 ENOG4105EC2 ftsk spoIIIe AOD66_10970 ENOG4105BZW Glycerate kinase AOD66_10975 ENOG4107QPK )-transporter AOD66_10980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD66_10985 ENOG41062D9 Histidine kinase AOD66_11000 ENOG4105C8J )-transporter AOD66_11020 ENOG4107XGZ Hydrolase AOD66_11025 ENOG4105CY2 Citrate transporter AOD66_11030 ENOG4105C0A alcohol dehydrogenase AOD66_11045 ENOG4105KD7 acetyltransferase AOD66_11075 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AOD66_11095 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AOD66_11110 ENOG4107RVG penicillin-binding protein AOD66_11115 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AOD66_11120 ENOG4105E9Q Acyl-transferase AOD66_11125 ENOG4108UT2 hemolysin iii AOD66_11135 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AOD66_11145 ENOG4108RCR degv family AOD66_11150 ENOG4105E8R UPF0173 metal-dependent hydrolase AOD66_11155 ENOG4108KF3 Electron transport protein SCO1 SenC AOD66_11160 ENOG4107Y70 Heat shock protein AOD66_11165 ENOG4105CAQ asparagine synthetase AOD66_11185 ENOG4108MES Periplasmic binding protein AOD66_11190 ENOG4105F0I Aminotransferase AOD66_11225 ENOG4105D8X mechanosensitive ion channel AOD66_11230 ENOG4105BZU Histidine kinase AOD66_11235 ENOG4105WH1 Two component transcriptional regulator luxr family AOD66_11245 ENOG4106KNT transcriptional regulator AOD66_11280 ENOG4105CMG Carbohydrate kinase AOD66_11285 ENOG4105CMG Carbohydrate kinase AOD66_11315 ENOG4108IJ8 ABC transporter AOD66_11320 ENOG4105E90 ABC transporter AOD66_11355 ENOG4105C37 (CBS) domain AOD66_11380 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOD66_11395 ENOG4107S4Y M20 DapE family protein YgeY AOD66_11400 ENOG4108TSC N-acetyltransferase AOD66_11405 ENOG4108JUB Transcriptional regulator AOD66_11410 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AOD66_11450 ENOG4108N23 SpoOM-related protein AOD66_11455 ENOG410841Q phosphoesterase PA-phosphatase related protein AOD66_11465 ENOG4105SZ6 Thioredoxin AOD66_11480 ENOG4108IBT Inherit from COG: transposase AOD66_11580 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOD66_11620 ENOG4105BZ4 penicillin-binding protein AOD66_11630 ENOG4105CZM Major Facilitator AOD66_11635 ENOG4105W8X HesB YadR YfhF-family protein AOD66_11645 ENOG4105DXD 2-methylcitrate dehydratase AOD66_11650 ENOG4105CR4 methylisocitrate lyase AOD66_11655 ENOG4105C1G acyl-Coa dehydrogenase AOD66_11660 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AOD66_11670 ENOG4105N14 lysine exporter protein LysE YggA AOD66_11675 ENOG4105E39 Enoyl-CoA hydratase AOD66_11690 ENOG4107RFY SbcCD D subunit AOD66_11695 ENOG4105EYH Exonuclease AOD66_11725 ENOG4105FCD Major Facilitator AOD66_11730 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AOD66_11735 ENOG4105E4F Isochorismate synthase AOD66_11740 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AOD66_11745 ENOG4105WQI isochorismatase AOD66_11750 ENOG4105CEY Amp-dependent synthetase and ligase AOD66_11755 ENOG4105WQT MbtH domain protein AOD66_11760 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD66_11775 ENOG4105K70 DNA-binding protein AOD66_11795 ENOG4105BZG amino acid carrier protein AOD66_11820 ENOG4105FE9 pseudouridine synthase AOD66_11825 ENOG4105C22 threonyL-tRNA synthetase AOD66_11840 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AOD66_11865 ENOG4108D32 Methyltransferase AOD66_11895 ENOG41081I9 integral membrane protein AOD66_11910 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AOD66_11920 ENOG4105EYF MMPL domain protein AOD66_11945 ENOG4105WCN acetyltransferase AOD66_11975 ENOG4105C1Q protoporphyrinogen oxidase AOD66_11985 ENOG41068WN AOD66_11995 ENOG4105VEQ Cold shock protein AOD66_12015 ENOG410667J hydrolase AOD66_12060 ENOG4107V2S Transcriptional regulator AOD66_12065 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AOD66_12080 ENOG4105DND Transcriptional regulator AOD66_12085 ENOG4108RPX mosc domain containing protein AOD66_12100 ENOG4105BZ1 (ABC) transporter AOD66_12105 ENOG4105BZ1 (ABC) transporter AOD66_12125 ENOG4108JCI Transcriptional regulator AOD66_12155 ENOG4108KPJ rna polymerase sigma factor AOD66_12180 ENOG4105F32 YngK protein AOD66_12205 ENOG4105RD7 BadF BadG BcrA BcrD AOD66_12215 ENOG4107STF Involved in phosphonate degradation (By similarity) AOD66_12235 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AOD66_12250 ENOG4105C1J atp-dependent rna helicase AOD66_12265 ENOG4108RZE Tetr family transcriptional regulator AOD66_12285 ENOG41088CC tellurite resistance protein tehB AOD66_12295 ENOG4108I0C methyltransferase AOD66_12300 ENOG4107RA9 decarboxylase AOD66_12305 ENOG41090HR transcriptional regulator AOD66_12345 ENOG4105CIN aminoacyl-histidine dipeptidase AOD66_12370 ENOG4107RF6 penicillin-binding protein AOD66_12385 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AOD66_12390 ENOG4105ETE Transcriptional regulator (LacI family AOD66_12395 ENOG4105IE8 Alpha-ketoglutarate permease AOD66_12400 ENOG4105CK5 oxidoreductase AOD66_12425 ENOG4105D2N Aldolase AOD66_12430 ENOG4105DH8 myo-inositol catabolism AOD66_12445 ENOG4105CGH 5'-nucleotidase AOD66_12455 ENOG4105CGH 5'-nucleotidase AOD66_12470 ENOG4105VZ8 Transcriptional regulator AOD66_12485 ENOG4108VXD carboxy-peptidase AOD66_12505 ENOG41067SE Tetr family transcriptional regulator AOD66_12510 ENOG4105C5H ABC transporter AOD66_12520 ENOG4105BZU Histidine kinase AOD66_12530 ENOG4106ANW SMI1_KNR4 AOD66_12535 ENOG4105CEP NADH dehydrogenase AOD66_12540 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AOD66_12555 ENOG4105CJ1 ABC, transporter AOD66_12565 ENOG4107Z3H Transcriptional regulator, TetR family AOD66_12580 ENOG4105C1G acyl-Coa dehydrogenase AOD66_12585 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AOD66_12590 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AOD66_12595 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AOD66_12600 ENOG4105E39 Enoyl-CoA hydratase AOD66_12605 ENOG4107QX3 carboxylase AOD66_12610 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AOD66_12620 ENOG4105WCN acetyltransferase AOD66_12625 ENOG4105DBI uridine monophosphokinase AOD66_12660 ENOG4105T9C HD domain AOD66_12670 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AOD66_12710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOD66_12710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOD66_12725 ENOG4105FQP Beta-lactamase AOD66_12735 ENOG4107Y80 Major Facilitator superfamily AOD66_12755 ENOG4105CUV Homoserine Kinase AOD66_12790 ENOG4105CPQ Dehydrogenase AOD66_12805 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOD66_12810 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOD66_12905 ENOG4105ETU transcriptional activator (TenA AOD66_13015 ENOG410667J hydrolase AOD66_13025 ENOG4105BZU Histidine kinase AOD66_13030 ENOG4107RF6 penicillin-binding protein AOD66_13050 ENOG4108JJB ABC transporter AOD66_13060 ENOG4108HGU Histidine kinase AOD66_13075 ENOG4105CB2 alcohol dehydrogenase AOD66_13080 ENOG4105CJN penicillin-binding protein AOD66_13090 ENOG4105FQP Beta-lactamase AOD66_13125 ENOG4108V4B ThiJ pfpI AOD66_13155 ENOG4107Y80 Major Facilitator superfamily AOD66_13170 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AOD66_13190 ENOG4107Y9U Membrane AOD66_13225 ENOG4105FCD Major Facilitator AOD66_13240 ENOG4105E09 nadh pyrophosphatase AOD66_13245 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AOD66_13250 ENOG4108Z4K mutator MutT protein AOD66_13285 ENOG4108XI2 Domain of unknown function (DUF1963) AOD66_13315 ENOG4108NRW Phospholipase, patatin family AOD66_13320 ENOG4105KWG Pfam:DUF1696 AOD66_13355 ENOG4105PKS Excinuclease abc c subunit domain protein AOD66_13395 ENOG4107VFR oxidoreductase AOD66_13420 ENOG4105PAD Hydrolase AOD66_13440 ENOG4105DY8 decarboxylase AOD66_13455 ENOG4108IUM Glycogen debranching enzyme AOD66_13480 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AOD66_13490 ENOG4105FDR Membrane AOD66_13525 ENOG4108V3A UPF0421 protein AOD66_13545 ENOG4105MSI germination protein ypeb AOD66_13565 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AOD66_13570 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AOD66_13575 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AOD66_13580 ENOG4107Z3H Transcriptional regulator, TetR family AOD66_13610 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AOD66_13630 ENOG4105E98 transcriptional regulator DeoR family AOD66_13650 ENOG41062ES Transcriptional regulator AOD66_13670 ENOG4107QKR Dehydrogenase AOD66_13680 ENOG4107RUY (E1 component), alpha subunit AOD66_13690 ENOG4105E1F short-chain dehydrogenase reductase AOD66_13695 ENOG4105RHY Pfam:UPF0157 AOD66_13730 ENOG4107SQ8 Glycine betaine AOD66_13735 ENOG4108IJ7 Glycine betaine AOD66_13760 ENOG4105E66 phosphoriboisomerase A AOD66_13765 ENOG41082BV acetyltransferase AOD66_13770 ENOG4108M1A Chitin-binding protein AOD66_13815 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AOD66_13865 ENOG4105EEM helicase AOD66_13885 ENOG4105C9U ATP-dependent DNA helicase RecQ AOD66_13940 ENOG4108M1A Chitin-binding protein AOD66_13955 ENOG4105BZG amino acid carrier protein AOD66_13960 ENOG4105C26 Dehydrogenase AOD66_13965 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AOD66_13970 ENOG4105CTU Proline racemase AOD66_13975 ENOG4105CTU Proline racemase AOD66_13980 ENOG41080HI glycine oxidase AOD66_14020 ENOG4107T5V SNARE associated Golgi AOD66_14035 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AOD66_14040 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AOD66_14055 ENOG4105DTQ mandelate racemase muconate lactonizing AOD66_14095 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AOD66_14100 ENOG4105BZU Histidine kinase AOD66_14105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD66_14145 ENOG4105EPR degv family AOD66_14185 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AOD66_14190 ENOG4106K7D Major facilitator family transporter AOD66_14210 ENOG4107BMA Transglycosylase associated protein AOD66_14225 ENOG41089UC methyltransferase, type 11 AOD66_14260 ENOG4105CHM Aminotransferase AOD66_14295 ENOG4105DVE abc transporter atp-binding protein AOD66_14345 ENOG4105C02 permease AOD66_14360 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AOD66_14365 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AOD66_14370 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AOD66_14395 ENOG4105E09 nadh pyrophosphatase AOD66_14415 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AOD66_14465 ENOG4107VC0 DNA alkylation repair enzyme AOD66_14475 ENOG4107VMI polysaccharide deacetylase AOD66_14485 ENOG4108ZCF integral membrane protein AOD66_14490 ENOG4105E0M Sulfatase AOD66_14495 ENOG4105C5H ABC transporter AOD66_14505 ENOG4105EYF MMPL domain protein AOD66_14510 ENOG4105EYF MMPL domain protein AOD66_14515 ENOG4105EYF MMPL domain protein AOD66_14520 ENOG41082JN Transcriptional regulator AOD66_14540 ENOG4105CIH Imidazole acetol-phosphate transaminase AOD66_14545 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AOD66_14550 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AOD66_14585 ENOG41069ER domain protein AOD66_14595 ENOG4105EMN RNA polymerase sigma factor AOD66_14620 ENOG4105D4B ABC, transporter AOD66_14630 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AOD66_14640 ENOG4105DKT Transcriptional regulator AOD66_14655 ENOG41061GT Aldolase AOD66_14675 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AOD66_14705 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AOD66_14710 ENOG4105II7 pyrroline-5-carboxylate reductase AOD66_14720 ENOG4107258 Transcriptional regulator AOD66_14730 ENOG4105E0Y RtcB Protein AOD66_14735 ENOG4105ECK Fatty Acid Desaturase AOD66_14740 ENOG4105G6Z alkaline phosphatase AOD66_14750 ENOG4105VMP Transcriptional regulator AOD66_14765 ENOG41090T1 Membrane AOD66_14775 ENOG4108WCX response regulator AOD66_14785 ENOG41068WN AOD66_14810 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOD66_14835 ENOG4105CKK Glycosyl transferase, family 2 AOD66_14860 ENOG4105CKK Glycosyl transferase, family 2 AOD66_14870 ENOG4105C8Y Acetylornithine aminotransferase AOD66_14910 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOD66_14920 ENOG4108TVJ Nitroreductase AOD66_14925 ENOG4105FS7 Transcriptional regulator AOD66_14960 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOD66_14970 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AOD66_15000 ENOG4108XET gCN5-related N-acetyltransferase AOD66_15080 ENOG410635A Membrane AOD66_15085 ENOG4105KNA -acetyltransferase AOD66_15090 ENOG4108IQI permease AOD66_15100 ENOG4105F1N DNA alkylation repair AOD66_15140 ENOG4107RF6 penicillin-binding protein AOD66_15150 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AOD66_15190 ENOG4105P4J Allophanate hydrolase, subunit 1 AOD66_15195 ENOG4107258 Transcriptional regulator AOD66_15205 ENOG4106N3A copper homeostasis protein cutc AOD66_15210 ENOG4108ZRV stage ii sporulation protein p AOD66_15215 ENOG4108ZHR arsR family transcriptional regulator AOD66_15225 ENOG4105FDT acyl-CoA dehydrogenase AOD66_15245 ENOG4105DWD nucleoside recognition domain protein AOD66_15275 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AOD66_15340 ENOG4105E2A Dehydrogenase AOD66_15355 ENOG4108IJ0 Aspartate ammonia-lyase AOD66_15360 ENOG4105HDK L-asparaginase AOD66_15365 ENOG4108IMY Transcriptional regulator AOD66_15375 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AOD66_15380 ENOG4105CUB amino acid AOD66_15390 ENOG4105II7 pyrroline-5-carboxylate reductase AOD66_15400 ENOG4105C6K Malic enzyme AOD66_15410 ENOG4108NHD germination protein AOD66_15415 ENOG4108NHD germination protein AOD66_15420 ENOG4108Q8B Spore germination protein AOD66_15440 ENOG4105CSV Glutaminase AOD66_15470 ENOG4105CGH 5'-nucleotidase AOD66_15475 ENOG4105CH6 catalase AOD66_15485 ENOG4105CHJ isochorismatase hydrolase AOD66_15550 ENOG4108606 TspO/MBR family AOD66_15555 ENOG4105CVP deoxyribo-dipyrimidine photolyase AOD66_15570 ENOG4108TWJ NADH dehydrogenase subunit 5 AOD66_15575 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AOD66_15585 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AOD66_15590 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AOD66_15595 ENOG4105DSE periplasmic solute binding protein AOD66_15600 ENOG4105CC5 ABC transporter AOD66_15605 ENOG4105DIK (ABC) transporter AOD66_15635 ENOG4105D6J arsenicaL-resistance protein AOD66_15640 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AOD66_15645 ENOG41085FC arsR family transcriptional regulator AOD66_15660 ENOG4105F7F Chaperone AOD66_15670 ENOG4105CHR reductase AOD66_15675 ENOG4108YXU transcriptional regulator AsnC family AOD66_15750 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AOD66_15760 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD66_15770 ENOG4105IIP Membrane AOD66_15785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD66_15790 ENOG41062D9 Histidine kinase AOD66_15820 ENOG4105K6H D-cysteine desulfhydrase AOD66_15845 ENOG4105VZ8 Transcriptional regulator AOD66_15860 ENOG4108NNI Beta-lactamase domain-containing protein AOD66_15865 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AOD66_15875 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOD66_15880 ENOG4105JQZ Methyltransferase AOD66_15895 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AOD66_15900 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AOD66_15920 ENOG4105BZU Histidine kinase AOD66_15935 ENOG4108U05 Transcriptional regulator AOD66_15950 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AOD66_15955 ENOG4105DJB Major Facilitator Superfamily AOD66_15960 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AOD66_15965 ENOG4107QR9 Iron-sulfur cluster binding protein AOD66_15975 ENOG4106P55 Transcriptional regulator AOD66_15985 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AOD66_16020 ENOG4105TRI Hydrolase AOD66_16055 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AOD66_16085 ENOG4107QJQ Mate efflux family protein AOD66_16100 ENOG4105EQ0 Major Facilitator superfamily AOD66_16105 ENOG4108JGH Tetr family transcriptional regulator AOD66_16120 ENOG4105C44 Serine transporter AOD66_16125 ENOG4105EJQ L-serine dehydratase AOD66_16140 ENOG4108JPW Aminotransferase AOD66_16155 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AOD66_16165 ENOG4105DVH amino acid AOD66_16180 ENOG4108JQ1 Dehydrogenase AOD66_16200 ENOG4108AEY RNA polymerase sigma factor AOD66_16215 ENOG41082W1 Cupin 2, conserved barrel domain protein AOD66_16225 ENOG410874W AraC family transcriptional regulator AOD66_16240 ENOG4105HIR S-layer domain protein AOD66_16280 ENOG4108ISG Major Facilitator AOD66_16290 ENOG4107MII Sugar-specific transcriptional regulator TrmB AOD66_16295 ENOG4105CZM Major Facilitator AOD66_16315 ENOG4105DA5 (ABC) transporter AOD66_16320 ENOG41069JR AOD66_16330 ENOG4105RXJ AOD66_16335 ENOG4105KPY Small multidrug resistance protein AOD66_16340 ENOG4105KBX Transcriptional regulator, TetR family AOD66_16355 ENOG4105CRW Short chain fatty acid transporter AOD66_16365 ENOG4105DYS nad(p)h dehydrogenase (quinone) AOD66_16395 ENOG4108JJB ABC transporter AOD66_16400 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AOD66_16425 ENOG4108K8S endonuclease I AOD66_16440 ENOG41067QW Transcriptional regulator AOD66_16450 ENOG4108Z66 YbaK ebsC protein AOD66_16455 ENOG4105CUT histidyl-tRNA synthetase AOD66_16470 ENOG4105KVH Transcriptional regulator AOD66_16475 ENOG4108RCM Nitroreductase AOD66_16495 ENOG4108PSK reductase AOD66_16505 ENOG4105CJ1 ABC, transporter AOD66_16565 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AOD66_16570 ENOG4105DKQ ROK family AOD66_16575 ENOG4106UW1 Major Facilitator superfamily AOD66_16580 ENOG4108UW5 maltose o-acetyltransferase AOD66_16595 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AOD66_16600 ENOG4105C31 Tryptophanyl-tRNA synthetase AOD66_16605 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AOD66_16630 ENOG4105DMQ Methyltransferase AOD66_16640 ENOG4105EV4 Multidrug resistance protein mdtH AOD66_16670 ENOG4105C37 (CBS) domain AOD66_16685 ENOG4105DDN Pentapeptide repeat-containing protein AOD66_16690 ENOG4105XDF Protein of unknown function (DUF1272) AOD66_16695 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AOD66_16700 ENOG4105CMG Carbohydrate kinase AOD66_16705 ENOG4105C6Z Gluconate AOD66_16710 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AOD66_16725 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AOD66_16730 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AOD66_16735 ENOG4105CIS alcohol dehydrogenase AOD66_16740 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AOD66_16760 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AOD66_16765 ENOG4105D4Y metalloprotease AOD66_16785 ENOG4105CV8 reductase AOD66_16790 ENOG4105F27 Major Facilitator AOD66_16805 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AOD66_16810 ENOG4105C44 Serine transporter AOD66_16845 ENOG4105KVH Transcriptional regulator AOD66_16850 ENOG4108TZY GntR Family Transcriptional Regulator AOD66_16860 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AOD66_16865 ENOG4105KVH Transcriptional regulator AOD66_16870 ENOG4105KVH Transcriptional regulator AOD66_16905 ENOG4105JAB phenazine biosynthesis protein, phzf family AOD66_16915 ENOG4105CHR reductase AOD66_16935 ENOG4105KVH Transcriptional regulator AOD66_17005 ENOG4105KAF membrAne AOD66_17030 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AOD66_17045 ENOG4107YXZ hydrolase, family 25 AOD66_17070 ENOG4105ED2 Beta-lactamase AOD66_17080 ENOG4105H3G oxidoreductase AOD66_17155 ENOG4108TN2 lmbE family AOD66_17165 ENOG4107R3E Citrate transporter AOD66_17185 ENOG4108MES Periplasmic binding protein AOD66_17195 ENOG4105EHG Permease protein AOD66_17200 ENOG4105DQ5 transport system permease protein AOD66_17205 ENOG4105NX3 Membrane AOD66_17210 ENOG4107ZY0 Phenazine biosynthesis-like protein AOD66_17230 ENOG4107CUJ Protein of unknown function (DUF2690) AOD66_17240 ENOG4107V2S Transcriptional regulator AOD66_17260 ENOG4105C98 muts2 protein AOD66_17270 ENOG4105E5K Alpha-amylase AOD66_17275 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AOD66_17280 ENOG4105DPN Oligoendopeptidase f AOD66_17285 ENOG4108A04 Beta-lactamase AOD66_17315 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AOD66_17340 ENOG41082BM Transcriptional regulator, arsr family AOD66_17345 ENOG4105CIS alcohol dehydrogenase AOD66_17370 ENOG4105RHY Pfam:UPF0157 AOD66_17380 ENOG4105C09 Bile acid AOD66_17385 ENOG4105CQB FAD linked oxidase domain protein AOD66_17410 ENOG4108UT6 Transferase hexapeptide repeat containing protein AOD66_17420 ENOG4105K64 Glycosyl transferase, family 2 AOD66_17425 ENOG4105E39 Enoyl-CoA hydratase AOD66_17435 ENOG4105KT7 mgtC SapB transporter AOD66_17445 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOD66_17450 ENOG41073R8 VanW family AOD66_17460 ENOG4108R1P AOD66_17480 ENOG4105VEQ Cold shock protein AOD66_17500 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AOD66_17520 ENOG410904N short-chain dehydrogenase reductase AOD66_17530 ENOG4106IQC argininosuccinate lyase AOD66_17545 ENOG4108IA2 Sodium pantothenate symporter AOD66_17555 ENOG4105C26 Dehydrogenase AOD66_17560 ENOG4105CHR reductase AOD66_17570 ENOG4105EWU Squalene--hopene cyclase AOD66_17580 ENOG4105FR1 rard protein AOD66_17585 ENOG410696E Membrane AOD66_17600 ENOG4105D1F ATP-binding protein AOD66_17610 ENOG4108ZAF Molybdopterin AOD66_17615 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOD66_17620 ENOG4105D06 uba thif-type nad fad binding protein AOD66_17625 ENOG4105TMB Formate nitrite transporter AOD66_17635 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AOD66_17640 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AOD66_17650 ENOG4108JB9 formate dehydrogenase AOD66_17660 ENOG4105E1K spore germination protein AOD66_17720 ENOG4107QJT sodium dicarboxylate symporter AOD66_17725 ENOG4108KGH TRANSCRIPTIONal AOD66_17735 ENOG4105EMN RNA polymerase sigma factor AOD66_17760 ENOG4105CIG ABC transporter AOD66_17770 ENOG4105D9R oxidoreductase AOD66_17780 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOD66_17790 ENOG4105K4P CoA-binding domain protein AOD66_17795 ENOG4105C0H protease AOD66_17800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD66_17810 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AOD66_17815 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AOD66_17820 ENOG4105W8X HesB YadR YfhF-family protein AOD66_17850 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AOD66_17855 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AOD66_17865 ENOG4108JJA ABC, transporter AOD66_17870 ENOG4108I0Z Aconitate hydratase AOD66_17900 ENOG4105E5W Transporter AOD66_17910 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOD66_17930 ENOG4107F3J Amp-dependent synthetase and ligase AOD66_17935 ENOG4107ZYJ bioY protein AOD66_17940 ENOG4105CEY Amp-dependent synthetase and ligase AOD66_17985 ENOG4107AYK membrAne AOD66_17995 ENOG4105BZU Histidine kinase AOD66_18000 ENOG4105FBA Phospholipase Carboxylesterase AOD66_18005 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AOD66_18010 ENOG4105CK7 Sodium proline symporter AOD66_18015 ENOG4105CBC glutamate synthase AOD66_18020 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AOD66_18025 ENOG4108VJ1 Transcriptional regulator (CarD family AOD66_18030 ENOG4108903 Formimidoylglutamase AOD66_18055 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AOD66_18115 ENOG4107QIV Cytochrome c biogenesis protein AOD66_18125 ENOG4107RSM transcriptional regulator AOD66_18130 ENOG4105VAW lrga family AOD66_18135 ENOG41067MG lrgb family AOD66_18160 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AOD66_18175 ENOG4105BZ1 (ABC) transporter AOD66_18180 ENOG4105BZ1 (ABC) transporter AOD66_18200 ENOG4105D7V transposase AOD66_18220 ENOG4105D5T phosphonate abc transporter AOD66_18235 ENOG4105CGH 5'-nucleotidase AOD66_18245 ENOG4108SVB resolvase AOD66_18265 ENOG4105K7K Transcriptional regulator AOD66_18300 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AOD66_18305 ENOG4105XSJ toxin secretion phage lysis holin AOD66_18515 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) AOD66_18620 ENOG4105C5F glutamine synthetase AOD66_18625 ENOG4105KV4 Transcriptional regulator AOD66_18630 ENOG4105CXI aluminum resistance protein AOD66_18640 ENOG4105EN6 Membrane AOD66_18645 ENOG4106F1P AAA ATPase, central domain protein AOD66_18675 ENOG41069ER domain protein AOD66_18680 ENOG4105DM4 PTS System AOD66_18685 ENOG4105DE4 1-phosphofructokinase AOD66_18690 ENOG4105E98 transcriptional regulator DeoR family AOD66_18700 ENOG4108SJC Membrane AOD66_18715 ENOG4105C85 amino acid AOD66_18730 ENOG4105TMB Formate nitrite transporter AOD66_18735 ENOG4105K70 DNA-binding protein AOD66_18740 ENOG4105C59 p-type ATPase AOD66_18745 ENOG410681U heavy metal transport detoxification protein AOD66_18750 ENOG4105VPX protein, conserved in bacteria AOD66_18760 ENOG4105NIV Esterase AOD66_18765 ENOG4105E0A ABC, transporter AOD66_18790 ENOG4105CGK Exodeoxyribonuclease III AOD66_18800 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AOD66_18805 ENOG4105D03 DNA-3-methyladenine glycosylase II AOD66_18835 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AOD66_18840 ENOG4105BZU Histidine kinase AOD66_18860 ENOG41067MG lrgb family AOD66_18875 ENOG4107TTQ Alpha beta hydrolase fold AOD66_18880 ENOG4107YEI lmbE family AOD66_18900 ENOG4105F0V Cell wall hydrolase AOD66_18905 ENOG4107R6R udp-galactopyranose mutase AOD66_18910 ENOG4105E0M Sulfatase AOD66_18915 ENOG410890F Dynamin family AOD66_18925 ENOG4107QHE Choloylglycine hydrolase AOD66_18950 ENOG4105DA5 (ABC) transporter AOD66_18975 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AOD66_18980 ENOG4105DQU oxidoreductase, subunit beta AOD66_18985 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AOD66_18990 ENOG4108IGT Dipeptidase AOD66_18995 ENOG4105MCT stage V sporulation protein S AOD66_19000 ENOG4105D48 metallophosphoesterase AOD66_19025 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AOD66_19040 ENOG4105XZV Protein of unknown function (DUF3243) AOD66_19045 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AOD66_19065 ENOG4105UIB (ABC) transporter AOD66_19070 ENOG4105UIB (ABC) transporter AOD66_19075 ENOG4108JQ9 ABC transporter AOD66_19080 ENOG4105DIH basic membrane AOD66_19085 ENOG4105FDP GntR family transcriptional regulator AOD66_19090 ENOG4107QZI cell division protein FtsK AOD66_19100 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AOD66_19115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AOD66_19125 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AOD66_19130 ENOG4108S0H Dipicolinic acid synthetase, b subunit AOD66_19135 ENOG4105E35 Dipicolinate synthase subunit A AOD66_19145 ENOG4105C1V Peptidase, M16 AOD66_19165 ENOG4105DTN riboflavin biosynthesis protein ribF AOD66_19170 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AOD66_19180 ENOG4105W7A Protein of unknown function (DUF503) AOD66_19190 ENOG4105VHM ribosomal protein AOD66_19195 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AOD66_19200 ENOG4105CHV Transcription elongation factor NusA AOD66_19210 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AOD66_19220 ENOG4105DZP Membrane-associated zinc metalloprotease AOD66_19225 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AOD66_19230 ENOG4105KNE Phosphatidate cytidylyltransferase AOD66_19235 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AOD66_19275 ENOG4108HE4 integrase family AOD66_19285 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AOD66_19295 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AOD66_19310 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AOD66_19335 ENOG4105VB6 UPF0109 protein AOD66_19355 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AOD66_19360 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AOD66_19375 ENOG4105CHR reductase AOD66_19380 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AOD66_19395 ENOG4105CB5 ATP-dependent DNA helicase recG AOD66_19400 ENOG4105DP4 dak2 domain fusion protein ylov AOD66_19405 ENOG4108ZAA Alkaline-shock protein AOD66_19420 ENOG4105FJ0 thiamine AOD66_19425 ENOG4105DJV ribulose-phosphate 3-epimerase AOD66_19430 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AOD66_19435 ENOG4105D9P serine threonine protein kinase AOD66_19440 ENOG4108ZF3 Phosphatase AOD66_19450 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AOD66_19460 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AOD66_19465 ENOG4105C25 Primosomal protein n' AOD66_19470 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AOD66_19490 ENOG4105DSJ YicC domain protein AOD66_19500 ENOG4105F23 Fibronectin-binding protein AOD66_19505 ENOG4105DC7 peptidase M24 AOD66_19560 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AOD66_19585 ENOG4105C34 Pseudouridine synthase AOD66_19600 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AOD66_19610 ENOG4105DBK s4 domain protein AOD66_19615 ENOG41067XK integral membrane protein AOD66_19625 ENOG4105DFA alanine racemase domain protein AOD66_19630 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AOD66_19635 ENOG4105WR5 sporulation protein, YlmC YmxH family AOD66_19645 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD66_19655 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AOD66_19660 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AOD66_19665 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AOD66_19670 ENOG4105D4A Cell wall formation (By similarity) AOD66_19675 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AOD66_19680 ENOG4105CNI cell division protein FtsW AOD66_19695 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOD66_19700 ENOG4105CJN penicillin-binding protein AOD66_19705 ENOG4105CJN penicillin-binding protein AOD66_19710 ENOG41068DC Essential cell division protein (By similarity) AOD66_19745 ENOG4105KNH Nucleic acid-binding protein AOD66_19795 ENOG4105XSJ toxin secretion phage lysis holin AOD66_19880 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AOD66_19890 ENOG4105CAR Terminase, large subunit AOD66_19980 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AOD66_19990 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD66_20045 ENOG4108IMY Transcriptional regulator AOD66_20070 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) AOD66_20080 ENOG41063PX domain protein AOD66_20085 ENOG4105D78 K07001 NTE family protein AOD66_20090 ENOG4105H20 Sporulation integral membrane protein YlbJ AOD66_20100 ENOG4106H78 methyltransferase AOD66_20120 ENOG4107TB6 phosphoglycerate mutase AOD66_20135 ENOG4106UY4 Inherit from COG: Scp-like extracellular AOD66_20185 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AOD66_20190 ENOG4105CNI cell division protein FtsW AOD66_20205 ENOG4108IAB Phoh family AOD66_20225 ENOG4105QA2 AOD66_20230 ENOG4105CI3 gtp-binding protein typa AOD66_20240 ENOG4105ECY inositol monophosphatase AOD66_20260 ENOG4105CXN decarboxylase AOD66_20305 ENOG4105C7S Dehydrogenase AOD66_20310 ENOG4105CPP Dehydrogenase, E1 component AOD66_20325 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AOD66_20330 ENOG4108X4Q Hydrolase AOD66_20340 ENOG4105CN5 Metallo-Beta-Lactamase AOD66_20345 ENOG4107ZYR domain protein AOD66_20380 ENOG4108XRC Protein of unknown function (DUF458) AOD66_20390 ENOG4107IN1 Protein of unknown function (DUF1797) AOD66_20405 ENOG4105EPM Diguanylate phosphodiesterase AOD66_20410 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AOD66_20425 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AOD66_20435 ENOG4105UIN AOD66_20500 ENOG4108HGU Histidine kinase AOD66_20510 ENOG4105CHM Aminotransferase AOD66_20515 ENOG4105FKQ transcriptional regulator AOD66_20520 ENOG4105EG2 ABC transporter, permease AOD66_20530 ENOG4107FKK extracellular solute-binding protein family 1 AOD66_20540 ENOG4105CG3 alpha amylase, catalytic region AOD66_20585 ENOG4105CHU acetyl-coa acetyltransferase AOD66_20625 ENOG4105K7K Transcriptional regulator AOD66_20630 ENOG4105DTD Dehydrogenase AOD66_20640 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AOD66_20650 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AOD66_20675 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AOD66_20695 ENOG4106TD9 Diguanylate cyclase AOD66_20715 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AOD66_20730 ENOG4105CID antiterminator AOD66_20740 ENOG4105FDP GntR family transcriptional regulator AOD66_20750 ENOG4105CE4 GlcNAc 6-P deacetylase AOD66_20795 ENOG4107ZE5 PPIases accelerate the folding of proteins AOD66_20800 ENOG4105PTM secreted protein AOD66_20805 ENOG4105J7I hydrolase AOD66_20815 ENOG4105G6R Stage v sporulation protein ae AOD66_20825 ENOG4105CZ3 stage V sporulation protein ad AOD66_20830 ENOG41090VF Stage v sporulation protein ac AOD66_20850 ENOG4105C8J )-transporter AOD66_20855 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD66_20865 ENOG41082AN stage II sporulation protein AOD66_20870 ENOG4105DZ1 carboxypeptidase AOD66_20875 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOD66_20880 ENOG4105DVE abc transporter atp-binding protein AOD66_20915 ENOG4105D7N magnesium and cobalt transport protein CorA AOD66_20940 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AOD66_20950 ENOG4105I3K Ferric uptake regulator, Fur family AOD66_20955 ENOG4105MZ9 stage II sporulation protein m AOD66_20975 ENOG4105CPC Aldo Keto reductase AOD66_20985 ENOG4105RHY Pfam:UPF0157 AOD66_21005 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AOD66_21015 ENOG4105ETE Transcriptional regulator (LacI family AOD66_21020 ENOG4108YM7 Gcn5-related n-acetyltransferase AOD66_21040 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AOD66_21045 ENOG4108R6K riboflavin synthase, subunit alpha AOD66_21065 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AOD66_21070 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOD66_21075 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOD66_21080 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AOD66_21090 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOD66_21100 ENOG4105DFD Na H antiporter AOD66_21105 ENOG4105CGH 5'-nucleotidase AOD66_21145 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AOD66_21160 ENOG4108IXY short-chain dehydrogenase reductase AOD66_21165 ENOG41069FQ Metallo-beta-lactamase superfamily AOD66_21175 ENOG4105II7 pyrroline-5-carboxylate reductase AOD66_21180 ENOG4105EJQ L-serine dehydratase AOD66_21205 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AOD66_21215 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AOD66_21220 ENOG4105D9U N-acetyltransferase AOD66_21235 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AOD66_21240 ENOG4108QEG Membrane AOD66_21245 ENOG4105CDA abc transporter atp-binding protein AOD66_21250 ENOG4105E5Q amino acid AbC transporter AOD66_21255 ENOG4108HW3 (ABC) transporter AOD66_21265 ENOG4105G7B Protein of unknown function (DUF2992) AOD66_21285 ENOG4105C7S Dehydrogenase AOD66_21290 ENOG4105CPP Dehydrogenase, E1 component AOD66_21310 ENOG4107RDP Dehydrogenase AOD66_21325 ENOG4108JUB Transcriptional regulator AOD66_21335 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AOD66_21350 ENOG4107QQR Sporulation AOD66_21360 ENOG4105S1Z Stage IV sporulation protein B AOD66_21365 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AOD66_21375 ENOG4105DX0 Hemolysin A AOD66_21385 ENOG4105CTB Polyprenyl synthetase AOD66_21410 ENOG4108ZSR alkaline shock protein AOD66_21415 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AOD66_21440 ENOG410644B Stage III sporulation protein af AOD66_21450 ENOG4105KQ4 Stage iii sporulation protein ad AOD66_21455 ENOG4108CQH stage III sporulation protein AC AOD66_21460 ENOG4105KR5 Stage iii sporulation protein AOD66_21465 ENOG4105CD2 stage iii sporulation protein aa AOD66_21490 ENOG4105DC7 peptidase M24 AOD66_21505 ENOG4105CBJ Metal-dependent enzyme AOD66_21515 ENOG4107YBY Hydrolase AOD66_21535 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AOD66_21540 ENOG4105WZW rhodanese family AOD66_21580 ENOG4105CJ1 ABC, transporter AOD66_21585 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOD66_21615 ENOG4105C0D helicase AOD66_21735 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AOD66_21740 ENOG4105C3R Methionine synthase AOD66_21755 ENOG4105C28 cystathionine AOD66_21760 ENOG4105C28 cystathionine AOD66_21785 ENOG4105C5X domain protein AOD66_21795 ENOG4105DKQ ROK family AOD66_21805 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AOD66_21820 ENOG4108UTW Plays a role in the regulation of phosphate uptake AOD66_21825 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AOD66_21830 ENOG4105E2Z phosphate ABC transporter (Permease AOD66_21835 ENOG4105C8U phosphate abc transporter AOD66_21840 ENOG4105PWN phosphate abc transporter AOD66_21845 ENOG4107RF6 penicillin-binding protein AOD66_21855 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOD66_21880 ENOG4105N80 Ferric uptake regulator, Fur family AOD66_21890 ENOG4105FDK ABC transporter AOD66_21895 ENOG4108JYZ YitT family AOD66_21900 ENOG41069ZM Protein of unknown function (DUF2624) AOD66_21925 ENOG4105EGD dinuclear metal center protein, YbgI family AOD66_21940 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD66_21945 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AOD66_21980 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AOD66_21985 ENOG4105KG3 cytidine deaminase AOD66_21990 ENOG4107YR5 Diacylglycerol kinase AOD66_22000 ENOG4105CTJ Metal Dependent Phosphohydrolase AOD66_22005 ENOG4105C9A Phoh family AOD66_22020 ENOG41068P3 sporulation protein YqfC AOD66_22025 ENOG4105KTH gatB Yqey AOD66_22035 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AOD66_22040 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AOD66_22060 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AOD66_22070 ENOG4105CSA Coproporphyrinogen iii oxidase AOD66_22075 ENOG4105KVH Transcriptional regulator AOD66_22100 ENOG4105TQK DNA polymerase iii, delta' subunit AOD66_22110 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AOD66_22115 ENOG4108UK2 deaminase AOD66_22120 ENOG4105KQC Competence protein AOD66_22130 ENOG4105DXX methyltransferase AOD66_22140 ENOG4108WF2 Metal Dependent Phosphohydrolase AOD66_22150 ENOG410812S Rna-binding protein AOD66_22160 ENOG4105CQW ribosome biogenesis GTPase YqeH AOD66_22165 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AOD66_22180 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD66_22200 ENOG4108TVJ Nitroreductase AOD66_22215 ENOG4105G6Z alkaline phosphatase AOD66_22225 ENOG4108MUZ hydrolase AOD66_22260 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AOD66_22265 ENOG4105MIR Phenylalanine 4-monooxygenase AOD66_22275 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOD66_22280 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOD66_22320 ENOG4105S6R Iron-hydroxamate transporter permease subunit AOD66_22325 ENOG4108V5C ABC transporter AOD66_22335 ENOG4108EKI Dehydrogenase AOD66_22340 ENOG4105C28 cystathionine AOD66_22370 ENOG4107XRG penicillin-binding protein AOD66_22385 ENOG4105CFP Peptidase U32 AOD66_22390 ENOG4105XYU peptidase (U32 family) AOD66_22395 ENOG4108VQJ O-methyltransferase AOD66_22400 ENOG4105HHA aminodeoxychorismate lyase AOD66_22420 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOD66_22430 ENOG4105C02 permease AOD66_22445 ENOG41060CR AOD66_22450 ENOG4105C7H Helicase, RecD TraA family AOD66_22460 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AOD66_22465 ENOG4105C3J Cysteine desulfurase AOD66_22475 ENOG4105D1H recombination factor protein RarA AOD66_22480 ENOG4108VCI transcription factor, rsfa family AOD66_22485 ENOG4105CUZ uba thif-type nad fad binding protein AOD66_22495 ENOG4105CUT histidyl-tRNA synthetase AOD66_22510 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AOD66_22520 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AOD66_22525 ENOG41076HS cation diffusion facilitator family transporter AOD66_22530 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AOD66_22540 ENOG4105CKP Polysaccharide Biosynthesis Protein AOD66_22545 ENOG4108QG2 Membrane AOD66_22555 ENOG4105VIE preprotein translocase, subunit YajC AOD66_22570 ENOG41061AI Protein of unknown function (DUF2905) AOD66_22585 ENOG4108HUF Transporter AOD66_22595 ENOG4108IPJ Membrane AOD66_22600 ENOG4108IPJ Membrane AOD66_22605 ENOG41082BM Transcriptional regulator, arsr family AOD66_22630 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AOD66_22635 ENOG4108IYU L-aspartate oxidase AOD66_22650 ENOG4108RPX mosc domain containing protein AOD66_22655 ENOG4105CQC Prephenate dehydratase AOD66_22675 ENOG4105EWM Histidine kinase AOD66_22690 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AOD66_22705 ENOG4105X36 (ribosomal) protein AOD66_22715 ENOG4105C03 ribonuclease AOD66_22730 ENOG4107QMS site-determining protein AOD66_22745 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AOD66_22750 ENOG4105DFF Rod shape-determining protein mreb AOD66_22770 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AOD66_22775 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AOD66_22785 ENOG41068KH stage VI sporulation protein D AOD66_22795 ENOG4105D52 delta-aminolevulinic acid dehydratase AOD66_22820 ENOG4105K56 Transcriptional regulator AOD66_22840 ENOG4108IUQ atp-dependent protease AOD66_22870 ENOG4108QCI YvbH-like oligomerisation region AOD66_22890 ENOG4105M59 Phosphodiesterase, mj0936 family AOD66_22895 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AOD66_22905 ENOG4108XJQ germination protein AOD66_22915 ENOG4108PCX Major Facilitator AOD66_22925 ENOG4105KBX Transcriptional regulator, TetR family AOD66_22940 ENOG4105PFC Transcriptional regulator AOD66_22955 ENOG4105DZC cytosine deaminase AOD66_22960 ENOG4105DZC cytosine deaminase AOD66_22965 ENOG4105DEF Extracellular solute-binding protein, family 5 AOD66_22970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD66_22985 ENOG4108JQ7 (ABC) transporter AOD66_22990 ENOG4108HRK Histidine kinase AOD66_22995 ENOG4105DY9 regulatoR AOD66_23010 ENOG41067S9 phage shock protein C, PspC AOD66_23015 ENOG4108JCI Transcriptional regulator AOD66_23025 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AOD66_23030 ENOG4108Z40 Transcriptional regulator AOD66_23035 ENOG4105RHA ABC transporter, permease AOD66_23040 ENOG4108IUX (ABC) transporter AOD66_23045 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AOD66_23055 ENOG4105E14 MotA TolQ exbB proton channel AOD66_23060 ENOG4108VXD carboxy-peptidase AOD66_23070 ENOG4105E33 succinate dehydrogenase AOD66_23080 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AOD66_23095 ENOG4105K63 Thioredoxin AOD66_23100 ENOG4105C10 Electron transfer flavoprotein AOD66_23105 ENOG4105BZJ Electron transfer flavoprotein AOD66_23110 ENOG41060WC Enoyl-CoA hydratase AOD66_23115 ENOG4107Z3H Transcriptional regulator, TetR family AOD66_23120 ENOG4105CEY Amp-dependent synthetase and ligase AOD66_23130 ENOG4105J76 Periplasmic binding protein AOD66_23135 ENOG4105S6R Iron-hydroxamate transporter permease subunit AOD66_23180 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD66_23195 ENOG4105DR4 Methyltransferase AOD66_23210 ENOG4105KFN sortase, SrtB family AOD66_23215 ENOG4105E0A ABC, transporter AOD66_23230 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AOD66_23240 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AOD66_23250 ENOG4105FE9 pseudouridine synthase AOD66_23265 ENOG4105DCG PHP domain protein AOD66_23300 ENOG4105C5S asparaginyl-tRNA synthetase AOD66_23305 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AOD66_23315 ENOG4108RWN rrna methyltransferase AOD66_23350 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD66_23355 ENOG4105CW7 secretion protein, HlyD family AOD66_23360 ENOG4108JGH Tetr family transcriptional regulator AOD66_23365 ENOG4105CN9 Peptidase m42 family protein AOD66_23385 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AOD66_23390 ENOG4105C22 threonyL-tRNA synthetase AOD66_23395 ENOG4108TDW sporulation protein YtxC AOD66_23415 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AOD66_23420 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AOD66_23425 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AOD66_23435 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AOD66_23440 ENOG4105C2M dna polymerase I AOD66_23445 ENOG4105BZU Histidine kinase AOD66_23450 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD66_23470 ENOG4108HMX isocitrate dehydrogenase (NADP) AOD66_23475 ENOG4105BZN citrate synthase AOD66_23490 ENOG4108REF Sporulation integral membrane protein ytvi AOD66_23495 ENOG4105FS0 cytoplasmic membrane protein AOD66_23520 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AOD66_23525 ENOG4105C6K Malic enzyme AOD66_23530 ENOG4105C0B DNA polymerase III (alpha subunit) AOD66_23535 ENOG4105VV2 AOD66_23545 ENOG4105SFS phosphoesterase RecJ domain protein AOD66_23580 ENOG4105DC7 peptidase M24 AOD66_23615 ENOG4105Z7P Acetyltransferase (GNAT) family AOD66_23620 ENOG41082W1 Cupin 2, conserved barrel domain protein AOD66_23630 ENOG4105VZ8 Transcriptional regulator AOD66_23650 ENOG4107YZX Universal stress protein AOD66_23690 ENOG4108JYZ YitT family AOD66_23710 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AOD66_23720 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AOD66_23725 ENOG4105KBJ sporulation protein ytfj AOD66_23740 ENOG4105EFZ amidohydrolase AOD66_23750 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AOD66_23775 ENOG4106KR7 LysR family Transcriptional regulator AOD66_23795 ENOG4105C28 cystathionine AOD66_23815 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AOD66_23825 ENOG4105EMN RNA polymerase sigma factor AOD66_23840 ENOG4105F1V Acetoin utilization protein AOD66_23845 ENOG4105W87 Cbs domain AOD66_23850 ENOG4105DGU Histone deacetylase AOD66_23860 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD66_23870 ENOG4107SNB ankyrin repeat protein YahD AOD66_23875 ENOG4105EP9 oxidoreductase AOD66_23905 ENOG4105ETE Transcriptional regulator (LacI family AOD66_23930 ENOG4105C88 aminopeptidase AOD66_23975 ENOG4108VDD TRNA binding domain protein AOD66_24005 ENOG4105C8F Beta-lactamase domain protein AOD66_24020 ENOG4108V15 phosphotransferase enzyme family AOD66_24025 ENOG4108IUM Glycogen debranching enzyme AOD66_24040 ENOG4107QSE Dipeptidase AOD66_24045 ENOG4107QSE Dipeptidase AOD66_24050 ENOG4105YW5 deoR family transcriptional regulator AOD66_24065 ENOG4105CBX hi0933 family AOD66_24100 ENOG4108VJ1 Transcriptional regulator (CarD family AOD66_24105 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AOD66_24110 ENOG4105CSC Glucose uptake protein AOD66_24125 ENOG4108ZAF Molybdopterin AOD66_24130 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AOD66_24135 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOD66_24145 ENOG4105D06 uba thif-type nad fad binding protein AOD66_24170 ENOG41085GJ domain protein AOD66_24180 ENOG4105DWV Homoserine O-trans-acetylase AOD66_24190 ENOG4108B31 Spore germination protein AOD66_24225 ENOG410605W Major Facilitator AOD66_24230 ENOG4107S91 Sodium hydrogen exchanger AOD66_24235 ENOG4105NCW Trka-c domain protein AOD66_24250 ENOG4105C19 ABC transporter AOD66_24270 ENOG4105N5T Radical SAM Protein AOD66_24280 ENOG4105DA5 (ABC) transporter AOD66_24310 ENOG4105E8V Alpha Beta Hydrolase Fold protein AOD66_24315 ENOG4108Z0R Transferase AOD66_24320 ENOG4105YVM Phosphoesterase, PA-phosphatase related AOD66_24325 ENOG4105BZF Glycosyl transferase (Group 1 AOD66_24335 ENOG4108RIR Molybdenum cofactor biosynthesis protein AOD66_24390 ENOG4105EGD dinuclear metal center protein, YbgI family AOD66_24395 ENOG4105BZU Histidine kinase AOD66_24400 ENOG4105BZU Histidine kinase AOD66_24405 ENOG4107S9D Alpha beta hydrolase AOD66_24425 ENOG4105D2X ABC transporter substrate-binding protein AOD66_24435 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AOD66_24490 ENOG4108V2W Carbonate dehydratase AOD66_24495 ENOG4105C4M (Ubiquinol oxidase) subunit I AOD66_24500 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AOD66_24545 ENOG41087YS Phage shock protein A AOD66_24580 ENOG4105BZU Histidine kinase AOD66_24585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD66_24610 ENOG4108UGV hypoxanthine phosphoribosyltransferase AOD66_24615 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AOD66_24650 ENOG4107ZTW SNARE associated Golgi AOD66_24665 ENOG4105C19 ABC transporter AOD66_24670 ENOG41086D8 Transcriptional regulator AOD66_24720 ENOG4105C6Z Gluconate AOD66_24725 ENOG4105FDP GntR family transcriptional regulator AOD66_24745 ENOG41069H0 dihydroorotase EC 3.5.2.3 AOD66_24775 ENOG4105DTQ mandelate racemase muconate lactonizing AOD66_24785 ENOG4108IPT Naphthoate synthase AOD66_24790 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AOD66_24795 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AOD66_24800 ENOG4105E4F Isochorismate synthase AOD66_24805 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AOD66_24815 ENOG4105VEQ Cold shock protein AOD66_24840 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AOD66_24850 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AOD66_24860 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOD66_24955 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AOD66_24990 ENOG4105KT7 mgtC SapB transporter AOD66_24995 ENOG4107PBV potassium channel AOD66_25005 ENOG4107QYV phosphohexose isomerase AOD66_25015 ENOG4105WG9 Conserved Protein AOD66_25025 ENOG4105CHM Aminotransferase AOD66_25030 ENOG4108ZB6 transcriptional regulator AsnC family AOD66_25035 ENOG4105C5I Dehydrogenase AOD66_25040 ENOG4108MUZ hydrolase AOD66_25050 ENOG4105C87 Aminotransferase class I and II AOD66_25065 ENOG4105Y38 Kinase-associated protein B AOD66_25075 ENOG4107R3E Citrate transporter AOD66_25090 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AOD66_25095 ENOG4105KA0 thioesterase Superfamily protein AOD66_25115 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AOD66_25135 ENOG41069ER domain protein AOD66_25150 ENOG4105CEP NADH dehydrogenase AOD66_25180 ENOG4105EWC Purine nucleoside phosphorylase AOD66_25200 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AOD66_25225 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOD66_25230 ENOG4105C4B ABC transporter, permease AOD66_25235 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AOD66_25280 ENOG41083MR nifu domain-containing protein AOD66_25295 ENOG4108W5N phosphatidylglycerophosphatase a AOD66_25310 ENOG4105DYS nad(p)h dehydrogenase (quinone) AOD66_25315 ENOG4105D4U had-superfamily hydrolase, subfamily iia AOD66_25330 ENOG4105CBT Fructose-1,6-bisphosphatase AOD66_25350 ENOG4105MMD transcriptional regulator AOD66_25355 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AOD66_25360 ENOG4107TXC Transcriptional regulator AOD66_25365 ENOG41090T1 Membrane AOD66_25390 ENOG4105FAA peptidase M23 AOD66_25400 ENOG4105KZD Domain of unknown function (DUF1805) AOD66_25405 ENOG4107R8B 5'-nucleotidase AOD66_25430 ENOG4105DIW FeS assembly protein SUFB AOD66_25435 ENOG4108UNV SUF system FeS assembly protein, NifU family AOD66_25440 ENOG4105C9B Cysteine desulfurase AOD66_25445 ENOG4105JRK feS assembly protein SufD AOD66_25450 ENOG4105C3K feS assembly ATPase SufC AOD66_25455 ENOG4105D01 (LipO)protein AOD66_25460 ENOG4105D01 (LipO)protein AOD66_25465 ENOG4108UMI ABC transporter, permease AOD66_25500 ENOG41080E8 Transcriptional regulator, Spx MgsR family AOD66_25550 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOD66_25575 ENOG4108W8B Beta-lactamase domain protein AOD66_25580 ENOG4105C1G acyl-Coa dehydrogenase AOD66_25590 ENOG4105CHU acetyl-coa acetyltransferase AOD66_25605 ENOG4105DZ1 carboxypeptidase AOD66_25625 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AOD66_25645 ENOG4108SUT Major Facilitator Superfamily AOD66_25650 ENOG4107R7I amino acid AOD66_25660 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AOD66_25670 ENOG4107AYK membrAne AOD66_25705 ENOG4107ZTW SNARE associated Golgi AOD66_25715 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AOD66_25720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD66_25725 ENOG4105BZU Histidine kinase AOD66_25735 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AOD66_25750 ENOG4105VG1 fes assembly suf system protein AOD66_25755 ENOG4105D4Y metalloprotease AOD66_25775 ENOG4107S91 Sodium hydrogen exchanger AOD66_25780 ENOG4105NCW Trka-c domain protein AOD66_25795 ENOG4108RMU ferritin dps family protein AOD66_25810 ENOG4108URH decarboxylase AOD66_25835 ENOG4105D9N nucleoside AOD66_25840 ENOG4105D9N nucleoside AOD66_25855 ENOG4108RYK Nad-dependent epimerase dehydratase AOD66_25870 ENOG4105CV8 reductase AOD66_25875 ENOG4105F27 Major Facilitator AOD66_25880 ENOG4105KVH Transcriptional regulator AOD66_25895 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AOD66_25900 ENOG4105D4A Cell wall formation (By similarity) AOD66_25910 ENOG4105C8Q Methyl-accepting chemotaxis AOD66_25920 ENOG4105WMR Protein CrcB homolog AOD66_25925 ENOG4105WMR Protein CrcB homolog AOD66_25940 ENOG4108MK9 spermidine N(1)-acetyltransferase AOD66_25945 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AOD66_25960 ENOG4108IPW abc transporter atp-binding protein AOD66_25965 ENOG4105CM4 permease protein AOD66_25990 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AOD66_26000 ENOG4105XZU Preprotein translocase, subunit SecG AOD66_26005 ENOG41067MG lrgb family AOD66_26105 ENOG4105EFC phage portal protein HK97 family AOD66_26130 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AOD66_26140 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AOD66_26145 ENOG4105CP7 Triose-phosphate isomerase AOD66_26170 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD66_26190 ENOG41090VF Stage v sporulation protein ac AOD66_26195 ENOG4105CZ3 stage V sporulation protein ad AOD66_26210 ENOG4105H67 Protein of unknown function (DUF421) AOD66_26215 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AOD66_26220 ENOG4105KRI phosphocarrier protein (HPr AOD66_26230 ENOG4105CHW UPF0052 protein AOD66_26240 ENOG4108Z4K mutator MutT protein AOD66_26250 ENOG4105C3M thioredoxin reductase AOD66_26260 ENOG4108S4C acetyltransferase AOD66_26280 ENOG41086DT Membrane protein of unknown function AOD66_26290 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOD66_26295 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AOD66_26300 ENOG4105D7V transposase AOD66_26315 ENOG4107TXC Transcriptional regulator AOD66_26340 ENOG4105HMI Membrane AOD66_26345 ENOG4105DUM transcriptional regulator, lysR family AOD66_26355 ENOG4108WS4 fmn reductase AOD66_26370 ENOG4105BZ1 (ABC) transporter AOD66_26380 ENOG4105CN1 protease AOD66_26385 ENOG4105CRP Part of the ABC transporter FtsEX involved in AOD66_26390 ENOG4105CAK Cell division ATP-binding protein ftsE AOD66_26405 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AOD66_26410 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AOD66_26415 ENOG4105MS2 ribosomal subunit Interface protein AOD66_26420 ENOG4105VEQ Cold shock protein AOD66_26425 ENOG41081UC Inherit from COG: Competence protein AOD66_26440 ENOG4105KVH Transcriptional regulator AOD66_26455 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AOD66_26460 ENOG4108KGH TRANSCRIPTIONal AOD66_26465 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AOD66_26470 ENOG4105C6Y Udp-glucose 6-dehydrogenase AOD66_26475 ENOG4105ESV Glycosyl transferase, family 4 AOD66_26485 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOD66_26500 ENOG410901P UPF0249 protein AOD66_26505 ENOG4105F8D glycoside hydrolase family 4 AOD66_26510 ENOG4105VCP PTS System AOD66_26515 ENOG4105CK1 PTS System AOD66_26525 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AOD66_26530 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AOD66_26535 ENOG4105VCP PTS System AOD66_26545 ENOG4105VZJ PTS System AOD66_26560 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AOD66_26565 ENOG4105ECB domain protein AOD66_26570 ENOG4107RSM transcriptional regulator AOD66_26615 ENOG4105DAA L-lactate AOD66_26625 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AOD66_26635 ENOG4105E0M Sulfatase AOD66_26670 ENOG4105C94 Transporter AOD66_26675 ENOG41069ER domain protein AOD66_26700 ENOG4105KBK Zinc finger, swim domain protein AOD66_26705 ENOG4105C0D helicase AOD66_26735 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD66_26745 ENOG4107RBB ABC transporter, permease AOD66_26750 ENOG4105C19 ABC transporter AOD66_26770 ENOG4105CXY transporter AOD66_26785 ENOG4105BZU Histidine kinase AOD66_26790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD66_26795 ENOG4105CMR udp-glucose 4-epimerase AOD66_26810 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AOD66_26815 ENOG4105EY8 ABC transporter AOD66_26870 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AOD66_26885 ENOG4105FRN stage II sporulation protein AOD66_26900 ENOG4105DY9 regulatoR AOD66_26905 ENOG4108IUW ABC transporter AOD66_26925 ENOG4106778 Protein of unknown function (DUF1146) AOD66_26930 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AOD66_26935 ENOG4105C8S subunit m AOD66_26940 ENOG4105D65 subunit l AOD66_26965 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AOD66_26970 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AOD66_26980 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AOD66_26985 ENOG4105BZU Histidine kinase AOD66_27035 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AOD66_27040 ENOG41062M3 atp synthase AOD66_27070 ENOG4108YZG isomerase AOD66_27085 ENOG4108VGI doxx family AOD66_27090 ENOG4107XC4 flavin reductase domain protein, FMN-binding AOD66_27105 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AOD66_27115 ENOG4108ZXQ stage ii sporulation protein r AOD66_27120 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AOD66_27125 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AOD66_27140 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AOD66_27145 ENOG4105CBT Fructose-1,6-bisphosphatase AOD66_27150 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AOD66_27185 ENOG4105C1G acyl-Coa dehydrogenase AOD66_27190 ENOG4105C1G acyl-Coa dehydrogenase AOD66_27195 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AOD66_27205 ENOG4105DF6 Fe-S oxidoreductase AOD66_27220 ENOG4105BZU Histidine kinase AOD66_27240 ENOG4105BZU Histidine kinase AOD66_27245 ENOG4105KCT ABC transporter AOD66_27250 ENOG4108M15 ABC transporter AOD66_27255 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AOD66_27275 ENOG4105IIU Aminopeptidase AOD66_27295 ENOG4105EMN RNA polymerase sigma factor AOD66_27305 ENOG410684U Domain of unknown function (DUF1934) AOD66_27330 ENOG4105CYW agmatinase AOD66_27340 ENOG4105DXB Major Facilitator superfamily AOD66_27345 ENOG4107SWG transcriptional regulator MERR family AOD66_27350 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AOD66_27355 ENOG4105BZ4 penicillin-binding protein AOD66_27360 ENOG4108XFG YwhD family AOD66_27365 ENOG4108Z4T Peptidase M50 AOD66_27370 ENOG41069HH 4-oxalocrotonate tautomerase AOD66_27375 ENOG4105DCI Phosphohydrolase AOD66_27380 ENOG4108MES Periplasmic binding protein AOD66_27385 ENOG4105E0A ABC, transporter AOD66_27390 ENOG4105EHG Permease protein AOD66_27395 ENOG4105DQ5 transport system permease protein AOD66_27400 ENOG4105DQ5 transport system permease protein AOD66_27410 ENOG4108VCI transcription factor, rsfa family AOD66_27425 ENOG4108IJ2 phosphate acetyltransferase AOD66_27440 ENOG4108VKI Cell wall hydrolase AOD66_27470 ENOG410667J hydrolase AOD66_27475 ENOG4105VCH membrane AOD66_27485 ENOG4108TU7 Inherit from COG: (ABC) transporter AOD66_27490 ENOG4105CJ1 ABC, transporter AOD66_27495 ENOG41090WU lipolytic protein G-D-S-L family AOD66_27510 ENOG4105D6E homoserine dehydrogenase AOD66_27535 ENOG4108Y4K DNA-binding transcriptional activator AOD66_27545 ENOG4105WH1 Two component transcriptional regulator luxr family AOD66_27555 ENOG4105DWF phosphomethylpyrimidine kinase AOD66_27560 ENOG4105BZU Histidine kinase AOD66_27565 ENOG4105VCD cytoplasmic protein AOD66_27570 ENOG4105D22 carbon starvation protein AOD66_27575 ENOG4105DY9 regulatoR AOD66_27580 ENOG41079KZ Major Facilitator Superfamily AOD66_27600 ENOG4105EN6 Membrane AOD66_27605 ENOG4106YBV Methyl-accepting chemotaxis AOD66_27615 ENOG4108S4H thioesterase Superfamily protein AOD66_27625 ENOG4105JEU Glycosyl transferase, family 2 AOD66_27630 ENOG4105C5H ABC transporter AOD66_27660 ENOG4105CKK Glycosyl transferase, family 2 AOD66_27665 ENOG41067SE Tetr family transcriptional regulator AOD66_27675 ENOG4105E0X reductase AOD66_27680 ENOG4106F5Q Membrane AOD66_27695 ENOG4105DY9 regulatoR AOD66_27700 ENOG4108HRK Histidine kinase AOD66_27705 ENOG4107RGD Major Facilitator superfamily AOD66_27720 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOD66_27730 ENOG4105IW1 AmiS UreI transporter AOD66_27740 ENOG4105CMR udp-glucose 4-epimerase AOD66_27745 ENOG4108UT2 hemolysin iii AOD66_27755 ENOG4105C1J atp-dependent rna helicase AOD66_27770 ENOG4105DPN Oligoendopeptidase f AOD66_27790 ENOG4105C0H protease AOD66_27795 ENOG4105Q2H domain protein AOD66_27810 ENOG4105BZU Histidine kinase AOD66_27815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD66_27845 ENOG4105CDU Replicative dna helicase AOD66_27855 ENOG4105BZR domain protein AOD66_27860 ENOG4108XMW Membrane AOD66_27870 ENOG4108UUM single-stranded DNA-binding protein AOD66_27880 ENOG4105C3G gtp-binding protein AOD66_27885 ENOG4105VDK protein, conserved in bacteria AOD66_27890 ENOG4105D8X mechanosensitive ion channel AOD66_27895 ENOG4108ZDA Sporulation protein YyaC AOD66_27900 ENOG4105FA0 parb-like partition protein AOD66_27905 ENOG4107QJE Chromosome Partitioning Protein AOD66_27925 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AOD66_27935 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins