locus-tag class description AOD69_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AOD69_00015 ENOG410848D S4 domain protein YaaA AOD69_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOD69_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AOD69_00100 ENOG4105ZMH deoxynucleoside kinase AOD69_00110 ENOG4105GTG Isochorismatase AOD69_00120 ENOG4108Z6B deaminase AOD69_00125 ENOG4105C6E dna polymerase iii AOD69_00145 ENOG41067KS pro-sigma K processing AOD69_00180 ENOG4105CXN decarboxylase AOD69_00190 ENOG4105FA2 dna polymerase iii AOD69_00195 ENOG4105MA4 psp1 domain protein AOD69_00205 ENOG41060K3 Methyltransferase AOD69_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AOD69_00220 ENOG4105KRN Transcriptional regulator, abrb family AOD69_00230 ENOG4105F8V Hydrolase, tatD family AOD69_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AOD69_00245 ENOG4105XFA sporulation peptidase YabG AOD69_00250 ENOG4105W42 Veg protein AOD69_00265 ENOG4105DFT pur operon repressor AOD69_00270 ENOG4105KME endoribonuclease L-psp AOD69_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AOD69_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AOD69_00300 ENOG4108JA2 transcriptioN-repair coupling factor AOD69_00305 ENOG4108M14 stage v sporulation protein t AOD69_00315 ENOG4108IY2 MazG family AOD69_00320 ENOG41082I2 s4 domain protein AOD69_00325 ENOG4105VYY sporulation protein yabp AOD69_00340 ENOG41060GV RNA binding s1 domain protein AOD69_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AOD69_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase AOD69_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AOD69_00385 ENOG4105C6T cysteine synthase AOD69_00390 ENOG4105CRQ synthase (Component I) AOD69_00395 ENOG4105DDQ anthranilate synthase AOD69_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AOD69_00405 ENOG4105EEI dihydropteroate synthase AOD69_00410 ENOG4105KRF dihydroneopterin aldolase AOD69_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AOD69_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AOD69_00455 ENOG4108Z0C Uvrb UvrC protein AOD69_00470 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AOD69_00480 ENOG4105CTP PilT protein domain protein AOD69_00500 ENOG4105D7W serine acetyltransferase AOD69_00515 ENOG4105C2N RNA methyltransferase TrmH family group 3 AOD69_00520 ENOG4105M0M Tetracycline resistance protein AOD69_00525 ENOG4105QIV RNA polymerase AOD69_00540 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AOD69_00565 ENOG4107Y49 methyltransferase AOD69_00575 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AOD69_00580 ENOG4105XPM ribosomal protein AOD69_00685 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AOD69_00710 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AOD69_00720 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AOD69_00730 ENOG41067V7 50S ribosomal protein L36 AOD69_00760 ENOG4108JJB ABC transporter AOD69_00765 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AOD69_00770 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AOD69_00795 ENOG4105D1F ATP-binding protein AOD69_00810 ENOG4108NMV polysaccharide deacetylase AOD69_00895 ENOG4105C8B TIGR00159 family AOD69_00900 ENOG4107U5W ybbr family AOD69_00915 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AOD69_00920 ENOG4108VQT Alpha beta hydrolase fold protein AOD69_00940 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AOD69_00945 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AOD69_00980 ENOG4108PSK reductase AOD69_00985 ENOG4108UMI ABC transporter, permease AOD69_00990 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOD69_00995 ENOG4105D01 (LipO)protein AOD69_01000 ENOG4105EE1 crotonyl-CoA reductase AOD69_01010 ENOG4105IQ5 FAD linked oxidase domain protein AOD69_01025 ENOG4105C2C drug resistance transporter, Bcr CflA AOD69_01040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOD69_01045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD69_01050 ENOG4105C3U ABC transporter AOD69_01055 ENOG4108JQ7 (ABC) transporter AOD69_01085 ENOG4108J59 Extracellular solute-binding protein, family 5 AOD69_01090 ENOG4108J59 Extracellular solute-binding protein, family 5 AOD69_01100 ENOG4105II7 pyrroline-5-carboxylate reductase AOD69_01110 ENOG4107XDY Nicotinamide Mononucleotide Transporter AOD69_01120 ENOG4105E0C molybdate abc transporter AOD69_01125 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOD69_01130 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOD69_01135 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AOD69_01150 ENOG4105EGI Transcriptional regulator AOD69_01165 ENOG4105F6E Acyl-transferase AOD69_01185 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AOD69_01200 ENOG4108RE7 deoxyribonuclease AOD69_01205 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AOD69_01230 ENOG4105C5H ABC transporter AOD69_01245 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AOD69_01255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD69_01260 ENOG4105C3U ABC transporter AOD69_01265 ENOG4108JQ7 (ABC) transporter AOD69_01290 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AOD69_01295 ENOG4105ERH Fumarylacetoacetate hydrolase AOD69_01305 ENOG4108SC4 )-transporter AOD69_01310 ENOG4105CPF Cell wall formation (By similarity) AOD69_01315 ENOG4105CPF Cell wall formation (By similarity) AOD69_01320 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AOD69_01335 ENOG4107ZXI Rhomboid family AOD69_01345 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AOD69_01350 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AOD69_01360 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AOD69_01460 ENOG4105K8N protein family UPF0079, ATPase AOD69_01465 ENOG41072GX Peptidase M22 Glycoprotease AOD69_01470 ENOG410801F ribosomal-protein-alanine acetyltransferase AOD69_01475 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AOD69_01480 ENOG4105C5H ABC transporter AOD69_01495 ENOG4108TYN CAAX amino terminal protease family protein AOD69_01515 ENOG4105C7N Xanthine uracil vitamin C permease AOD69_01525 ENOG4105BZU Histidine kinase AOD69_01555 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOD69_01595 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOD69_01615 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD69_01635 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AOD69_01640 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AOD69_01645 ENOG4105C83 adenylosuccinate lyase AOD69_01655 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AOD69_01680 ENOG4108V3E phosphoribosylglycinamide formyltransferase AOD69_01690 ENOG4105C12 Phosphoribosylglycinamide synthetase AOD69_01715 ENOG4105C4R Atp-dependent dna helicase AOD69_01745 ENOG4108W2Y isochorismatase AOD69_01750 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOD69_01755 ENOG4108UMI ABC transporter, permease AOD69_01760 ENOG4105D01 (LipO)protein AOD69_01780 ENOG410834F Transcriptional regulator AOD69_01805 ENOG4105CBD Diacylglycerol kinase AOD69_01810 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AOD69_01815 ENOG4108JPW Aminotransferase AOD69_01825 ENOG4105C26 Dehydrogenase AOD69_01830 ENOG4105KPY Small multidrug resistance protein AOD69_01850 ENOG4105D9N nucleoside AOD69_01855 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AOD69_01870 ENOG4108W15 Protein of unknown function (DUF1456) AOD69_01885 ENOG4105DTQ mandelate racemase muconate lactonizing AOD69_01895 ENOG4105DFD Na H antiporter AOD69_01915 ENOG4105D3R alkyl hydroperoxide reductase AOD69_01920 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AOD69_01930 ENOG4107W7X Aldolase AOD69_01935 ENOG4105EHG Permease protein AOD69_01940 ENOG4105DQ5 transport system permease protein AOD69_01945 ENOG4108V5C ABC transporter AOD69_01970 ENOG4106UIA AOD69_01975 ENOG4106UIA AOD69_02000 ENOG4105BZU Histidine kinase AOD69_02020 ENOG410756H nucleotidyltransferase AOD69_02025 ENOG4105D2S major facilitator superfamily AOD69_02040 ENOG4105E5Q amino acid AbC transporter AOD69_02045 ENOG4105EAB amino acid AbC transporter AOD69_02060 ENOG4105C8Q Methyl-accepting chemotaxis AOD69_02065 ENOG4105C8Q Methyl-accepting chemotaxis AOD69_02075 ENOG4105CI1 PTS System AOD69_02105 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AOD69_02120 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AOD69_02135 ENOG4105C5H ABC transporter AOD69_02160 ENOG41062JF Transcriptional regulator AOD69_02180 ENOG4105DEU major facilitator superfamily AOD69_02195 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) AOD69_02210 ENOG4108N0M stress protein AOD69_02215 ENOG4106FN3 tellurium resistance protein AOD69_02220 ENOG4106FN3 tellurium resistance protein AOD69_02225 ENOG4107TS3 membrane protein, TerC AOD69_02230 ENOG4108TTB tellurium resistance protein AOD69_02250 ENOG4105KJF protein tyrosine phosphatase AOD69_02260 ENOG4107U9T Pfam:Ribonuclease_BN AOD69_02265 ENOG4105C59 p-type ATPase AOD69_02270 ENOG4108IPJ Membrane AOD69_02290 ENOG4107ZTW SNARE associated Golgi AOD69_02305 ENOG410606W general stress protein AOD69_02310 ENOG4105UPD Calcium Proton AOD69_02350 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AOD69_02355 ENOG4105VTR Integrase AOD69_02360 ENOG4108IMY Transcriptional regulator AOD69_02635 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AOD69_02645 ENOG4108JUB Transcriptional regulator AOD69_02655 ENOG4108IQI permease AOD69_02690 ENOG4105CSV Glutaminase AOD69_02700 ENOG4108A04 Beta-lactamase AOD69_02715 ENOG4105CKK Glycosyl transferase, family 2 AOD69_02725 ENOG4107QQG Dehydrogenase AOD69_02730 ENOG4105C3I Nad-dependent epimerase dehydratase AOD69_02750 ENOG4105F1A Pyruvate formate-lyase AOD69_02770 ENOG4105CI2 imidazolone-5-propionate hydrolase AOD69_02775 ENOG4105ECP epimerase AOD69_02805 ENOG41067AE Membrane-bound metal-dependent hydrolase AOD69_02810 ENOG4105CEN a g-specific adenine glycosylase AOD69_02815 ENOG4106BXE AOD69_02835 ENOG4105BZ1 (ABC) transporter AOD69_02840 ENOG4107NBY Membrane AOD69_02845 ENOG4105CBC glutamate synthase AOD69_02855 ENOG4108IUW ABC transporter AOD69_02875 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AOD69_02880 ENOG4105G5W regulator Fur family AOD69_02995 ENOG4108JQC penicillin-binding protein 1A AOD69_03000 ENOG4107ZQN disulfide bond AOD69_03010 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AOD69_03020 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AOD69_03025 ENOG4105BZU Histidine kinase AOD69_03035 ENOG4105CYN Serine protein kinase AOD69_03060 ENOG4105C94 Transporter AOD69_03075 ENOG4105DZ6 Band 7 protein AOD69_03085 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AOD69_03095 ENOG4105D4T Citrate transporter AOD69_03115 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AOD69_03120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOD69_03125 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AOD69_03130 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AOD69_03135 ENOG4105BZ7 extracellular solute-binding protein family 1 AOD69_03140 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AOD69_03145 ENOG4108STX response regulator AOD69_03150 ENOG4105US7 Histidine kinase AOD69_03175 ENOG4108MRH transcriptional regulatory protein AOD69_03185 ENOG4105C6K Malic enzyme AOD69_03195 ENOG4108UZ3 Transporter AOD69_03200 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AOD69_03210 ENOG4105BZU Histidine kinase AOD69_03215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD69_03225 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AOD69_03230 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AOD69_03235 ENOG4108JB9 formate dehydrogenase AOD69_03255 ENOG4105CUB amino acid AOD69_03265 ENOG4105C59 p-type ATPase AOD69_03270 ENOG4105DAP Nicotinate phosphoribosyltransferase AOD69_03300 ENOG41073R8 VanW family AOD69_03305 ENOG4108KGH TRANSCRIPTIONal AOD69_03310 ENOG4105D9N nucleoside AOD69_03315 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AOD69_03320 ENOG4105C37 (CBS) domain AOD69_03325 ENOG4108IJ0 Aspartate ammonia-lyase AOD69_03330 ENOG4105DAA L-lactate AOD69_03345 ENOG4105DUX Transporter AOD69_03350 ENOG4108MES Periplasmic binding protein AOD69_03355 ENOG4105DQ5 transport system permease protein AOD69_03360 ENOG4108IHU transport system permease protein AOD69_03365 ENOG4105E0A ABC, transporter AOD69_03370 ENOG4105DMQ Methyltransferase AOD69_03390 ENOG4107T89 von Willebrand factor, type A AOD69_03395 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AOD69_03400 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOD69_03415 ENOG4105BZU Histidine kinase AOD69_03420 ENOG4105D5Q Arginine ornithine antiporter AOD69_03425 ENOG4107414 GntR family transcriptional regulator AOD69_03430 ENOG4105C5Y PTS System AOD69_03435 ENOG4105CG3 alpha amylase, catalytic region AOD69_03450 ENOG4105E1K spore germination protein AOD69_03460 ENOG4105CRN Aminoglycoside phosphotransferase AOD69_03465 ENOG4105BZG amino acid carrier protein AOD69_03470 ENOG4105CDA abc transporter atp-binding protein AOD69_03475 ENOG4105CT1 (ABC) transporter AOD69_03480 ENOG4105EAD ABC transporter AOD69_03485 ENOG4105DRP amino acid AbC transporter AOD69_03490 ENOG4108IQI permease AOD69_03515 ENOG4105D29 Helix-turn-helix type 11 domain protein AOD69_03520 ENOG4105NAE bifunctional deaminase-reductase domain protein AOD69_03525 ENOG4105BZU Histidine kinase AOD69_03540 ENOG4105CHH sulfate transporter AOD69_03545 ENOG41068KF Universal stress protein AOD69_03555 ENOG4105DEF Extracellular solute-binding protein, family 5 AOD69_03565 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOD69_03570 ENOG4108JQ7 (ABC) transporter AOD69_03575 ENOG4105C3U ABC transporter AOD69_03580 ENOG4105CXY transporter AOD69_03585 ENOG41067TZ transcriptional regulator, MarR family AOD69_03590 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD69_03595 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD69_03600 ENOG4105ETE Transcriptional regulator (LacI family AOD69_03605 ENOG4108RVA ribokinase AOD69_03615 ENOG4105C2J ABC transporter AOD69_03620 ENOG4105CNN ABC, transporter AOD69_03625 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AOD69_03630 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AOD69_03690 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOD69_03695 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AOD69_03700 ENOG41069ER domain protein AOD69_03705 ENOG4105VZ8 Transcriptional regulator AOD69_03710 ENOG4107D63 AOD69_03720 ENOG4105DUX Transporter AOD69_03740 ENOG4105C85 amino acid AOD69_03745 ENOG4105C7N Xanthine uracil vitamin C permease AOD69_03785 ENOG4105BZ9 Cytochrome C oxidase, subunit I AOD69_03790 ENOG4105E2S oxidase) subunit II AOD69_03795 ENOG4108IQI permease AOD69_03810 ENOG4106CAD Protein of unknown function (DUF3311) AOD69_03815 ENOG4105E1V na solute symporter AOD69_03830 ENOG4108NHD germination protein AOD69_03840 ENOG4105CE1 Ferrous iron transport protein b AOD69_03845 ENOG4105CE1 Ferrous iron transport protein b AOD69_03850 ENOG4105CE1 Ferrous iron transport protein b AOD69_03855 ENOG4105CVA phosphate AOD69_03860 ENOG4105C8U phosphate abc transporter AOD69_03865 ENOG4105E2Z phosphate ABC transporter (Permease AOD69_03990 ENOG41080XQ Signal transduction protein with cbs domains AOD69_04015 ENOG4105ETU transcriptional activator (TenA AOD69_04025 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AOD69_04035 ENOG4108VEU Thiamine monophosphate synthase AOD69_04040 ENOG41080HI glycine oxidase AOD69_04055 ENOG4105D06 uba thif-type nad fad binding protein AOD69_04060 ENOG4105DWF phosphomethylpyrimidine kinase AOD69_04105 ENOG4108INS Transcriptional regulator AOD69_04120 ENOG4105C7N Xanthine uracil vitamin C permease AOD69_04150 ENOG4105C5Y PTS System AOD69_04210 ENOG4107Y03 Nitroreductase AOD69_04215 ENOG4105ED1 spovr family AOD69_04240 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AOD69_04245 ENOG4105XTG Pfam:DUF156 AOD69_04250 ENOG4105VFE sira family AOD69_04255 ENOG4107TPS domain protein AOD69_04260 ENOG4105VFE sira family AOD69_04265 ENOG41085GJ domain protein AOD69_04275 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AOD69_04280 ENOG41087NI Sulfite exporter TauE/SafE AOD69_04290 ENOG4108KGH TRANSCRIPTIONal AOD69_04315 ENOG4105EMD TRANSCRIPTIONal AOD69_04320 ENOG4105VCP PTS System AOD69_04325 ENOG4105VZJ PTS System AOD69_04345 ENOG41069ER domain protein AOD69_04350 ENOG4107RBB ABC transporter, permease AOD69_04355 ENOG4105C19 ABC transporter AOD69_04385 ENOG4105WEF catalase AOD69_04420 ENOG4107T5V SNARE associated Golgi AOD69_04455 ENOG4105CUB amino acid AOD69_04460 ENOG4107RWR Sodium hydrogen exchanger AOD69_04470 ENOG4106KNT transcriptional regulator AOD69_04505 ENOG4108PCN EamA-like transporter family AOD69_04510 ENOG4108YXU transcriptional regulator AsnC family AOD69_04520 ENOG4105KPY Small multidrug resistance protein AOD69_04525 ENOG4105KPY Small multidrug resistance protein AOD69_04550 ENOG4105NF4 modulator of drug activity AOD69_04555 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AOD69_04560 ENOG4105E5W Transporter AOD69_04570 ENOG4107RKG DJ-1/PfpI family AOD69_04575 ENOG4105CH6 catalase AOD69_04585 ENOG4105D5Q Arginine ornithine antiporter AOD69_04590 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AOD69_04600 ENOG4105C26 Dehydrogenase AOD69_04610 ENOG4105BZ1 (ABC) transporter AOD69_04625 ENOG4105DRP amino acid AbC transporter AOD69_04630 ENOG4105CDA abc transporter atp-binding protein AOD69_04645 ENOG410839P AOD69_04680 ENOG4107FQX Alpha-acetolactate decarboxylase AOD69_04710 ENOG4105D4P Coproporphyrinogen iii oxidase AOD69_04725 ENOG4105CHH sulfate transporter AOD69_04765 ENOG4106AKK s-layer domain-containing protein AOD69_04775 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOD69_04780 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOD69_04795 ENOG4105CGU Enoyl-CoA hydratase AOD69_04815 ENOG4105DER m42 family AOD69_04835 ENOG4105CTU Proline racemase AOD69_04880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD69_04890 ENOG4108JQ7 (ABC) transporter AOD69_04920 ENOG4105CSH Transporter AOD69_04930 ENOG4108MRH transcriptional regulatory protein AOD69_04980 ENOG4105CDU Replicative dna helicase AOD69_05020 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD69_05070 ENOG4107P5I polyketide synthase AOD69_05075 ENOG4108IG5 Transcriptional regulator AOD69_05095 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AOD69_05115 ENOG4105CMT Dihydroxyacetone kinase AOD69_05130 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AOD69_05135 ENOG410847I Transcriptional regulator, BadM Rrf2 family AOD69_05160 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AOD69_05225 ENOG4105WN5 stage II sporulation protein AOD69_05235 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD69_05245 ENOG4108MJI response regulator AOD69_05250 ENOG4105BZU Histidine kinase AOD69_05255 ENOG4105BZU Histidine kinase AOD69_05280 ENOG4105K8R UPF0145 protein AOD69_05315 ENOG4107VRP DNA repair exonuclease AOD69_05320 ENOG4106D4I domain protein AOD69_05325 ENOG4105D7V transposase AOD69_05340 ENOG4108IND Tetr family transcriptional regulator AOD69_05345 ENOG4105EQ0 Major Facilitator superfamily AOD69_05365 ENOG4108MUZ hydrolase AOD69_05385 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AOD69_05400 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AOD69_05415 ENOG4105EMN RNA polymerase sigma factor AOD69_05440 ENOG4105C57 major facilitator superfamily AOD69_05445 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD69_05455 ENOG4105EEM helicase AOD69_05460 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOD69_05490 ENOG4105K59 histidine triad (HIT) protein AOD69_05520 ENOG410905X membrane-flanked domain protein AOD69_05530 ENOG4105CKV Membrane AOD69_05570 ENOG410905X membrane-flanked domain protein AOD69_05575 ENOG4105CKV Membrane AOD69_05580 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AOD69_05585 ENOG4105BZ4 penicillin-binding protein AOD69_05590 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AOD69_05600 ENOG4105C1Q protoporphyrinogen oxidase AOD69_05625 ENOG4105NA0 Transcriptional regulator AOD69_05640 ENOG4105ECB domain protein AOD69_05670 ENOG4106AXD AOD69_05675 ENOG4108RQ5 Beta-lactamase domain-containing protein AOD69_05680 ENOG4105DF9 Lipoate-protein, ligase AOD69_05690 ENOG4105CEY Amp-dependent synthetase and ligase AOD69_05720 ENOG4105CNA YD repeat protein AOD69_05755 ENOG4105ENX hydrolase AOD69_05765 ENOG4107RN3 metallophosphoesterase AOD69_05770 ENOG4107TVP HD domain protein AOD69_05780 ENOG4108AEY RNA polymerase sigma factor AOD69_05785 ENOG41086D8 Transcriptional regulator AOD69_05805 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD69_05830 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AOD69_05835 ENOG4105C8Q Methyl-accepting chemotaxis AOD69_05855 ENOG4105ZU5 s-layer protein AOD69_05860 ENOG4107QP3 malate synthase g AOD69_05875 ENOG4105VEQ Cold shock protein AOD69_05890 ENOG4105XVF Competence transcription factor AOD69_05905 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AOD69_05910 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AOD69_05955 ENOG4105ERH Fumarylacetoacetate hydrolase AOD69_05980 ENOG4105CAQ asparagine synthetase AOD69_05985 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AOD69_05990 ENOG4105CH6 catalase AOD69_05995 ENOG4105BZU Histidine kinase AOD69_06020 ENOG4105QNR S1 RNA binding domain protein AOD69_06030 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOD69_06040 ENOG4107AYK membrAne AOD69_06045 ENOG41073B9 AOD69_06055 ENOG4108KP7 hydrolase AOD69_06070 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AOD69_06095 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOD69_06100 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AOD69_06115 ENOG4105C31 Tryptophanyl-tRNA synthetase AOD69_06130 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOD69_06135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD69_06145 ENOG4108JQ7 (ABC) transporter AOD69_06150 ENOG4105UQX Mate efflux family protein AOD69_06175 ENOG4108ZCF integral membrane protein AOD69_06185 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOD69_06195 ENOG4105DPN Oligoendopeptidase f AOD69_06210 ENOG4108Z18 K06886 hemoglobin AOD69_06215 ENOG4105MIX Adenylate cyclase AOD69_06230 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AOD69_06235 ENOG4105EMS pseudouridine synthase AOD69_06255 ENOG4105K64 Glycosyl transferase, family 2 AOD69_06275 ENOG4107TVC Glycosyl transferase, family 2 AOD69_06295 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AOD69_06300 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AOD69_06310 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AOD69_06360 ENOG4108WVJ 2'-5' rna ligase AOD69_06385 ENOG4105CK7 Sodium proline symporter AOD69_06395 ENOG4105CRQ synthase (Component I) AOD69_06400 ENOG4105DDQ anthranilate synthase AOD69_06490 ENOG4105C7S Dehydrogenase AOD69_06500 ENOG4105VZ8 Transcriptional regulator AOD69_06560 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AOD69_06570 ENOG4105DZ1 carboxypeptidase AOD69_06575 ENOG4105VFR signal peptidase AOD69_06610 ENOG4105C26 Dehydrogenase AOD69_06615 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOD69_06620 ENOG4105F38 ABC transporter, permease AOD69_06625 ENOG4105D38 putrescine abc transporter AOD69_06630 ENOG4107RUE extracellular solute-binding protein family 1 AOD69_06640 ENOG4105EYF MMPL domain protein AOD69_06650 ENOG4108YBP pseudouridine synthase AOD69_06660 ENOG4105K4I Scp-like extracellular AOD69_06665 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AOD69_06670 ENOG4105CQB FAD linked oxidase domain protein AOD69_06685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD69_06690 ENOG4105BZU Histidine kinase AOD69_06695 ENOG4105JXH GntR family transcriptional regulator AOD69_06715 ENOG4106A3R peptidase AOD69_06725 ENOG4108QTI )-transporter AOD69_06730 ENOG4107TS3 membrane protein, TerC AOD69_06735 ENOG4105CZN Potassium uptake protein AOD69_06740 ENOG410681C small acid-soluble spore protein AOD69_06745 ENOG4108Z7G MaoC domain protein dehydratase AOD69_06765 ENOG4105CHR reductase AOD69_06775 ENOG4105MWK D-amino acid dehydrogenase, small subunit AOD69_06795 ENOG4105C4Y ABC transporter AOD69_06810 ENOG4107RCV ABC transporter, permease AOD69_06815 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AOD69_06830 ENOG4105E98 transcriptional regulator DeoR family AOD69_06855 ENOG4105PXI polysaccharide deacetylase AOD69_06865 ENOG4105BZU Histidine kinase AOD69_06870 ENOG41090MY MarR family Transcriptional regulator AOD69_06880 ENOG4106DF1 AOD69_06890 ENOG4105BZU Histidine kinase AOD69_06900 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AOD69_06905 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AOD69_06950 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AOD69_06970 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AOD69_06975 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AOD69_06980 ENOG4105CZV ABC transporter AOD69_06990 ENOG4105CJ1 ABC, transporter AOD69_07030 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AOD69_07035 ENOG4105EA8 2-Nitropropane dioxygenase AOD69_07040 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AOD69_07050 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOD69_07075 ENOG4105NQC Flavodoxin AOD69_07110 ENOG4107QMU Mate efflux family protein AOD69_07115 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOD69_07145 ENOG4105CZN Potassium uptake protein AOD69_07150 ENOG41063Y9 AOD69_07155 ENOG4105KBJ sporulation protein ytfj AOD69_07185 ENOG4105CM2 brancheD-chain amino acid aminotransferase AOD69_07190 ENOG4105C7K acetolactate synthase AOD69_07195 ENOG4108ZP8 Acetolactate synthase small subunit AOD69_07200 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AOD69_07210 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AOD69_07235 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AOD69_07270 ENOG4107RVV histidinol phosphate phosphatase, hisj family AOD69_07285 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AOD69_07290 ENOG4105E0M Sulfatase AOD69_07300 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AOD69_07320 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AOD69_07325 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AOD69_07335 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AOD69_07340 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AOD69_07345 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AOD69_07355 ENOG4105C8J )-transporter AOD69_07375 ENOG4105DFD Na H antiporter AOD69_07395 ENOG4105ENE Histidine kinase AOD69_07400 ENOG4105WH1 Two component transcriptional regulator luxr family AOD69_07420 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AOD69_07445 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AOD69_07470 ENOG4105CJ3 phosphate transporter AOD69_07475 ENOG4107GRR phosphate transport regulator AOD69_07480 ENOG4105BZ4 penicillin-binding protein AOD69_07495 ENOG4105BZU Histidine kinase AOD69_07500 ENOG4105I3N Conserved Protein AOD69_07515 ENOG4105BZU Histidine kinase AOD69_07550 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOD69_07555 ENOG4105DZ1 carboxypeptidase AOD69_07560 ENOG4108JIC nucleoside recognition domain protein AOD69_07570 ENOG4105FE9 pseudouridine synthase AOD69_07580 ENOG4107TWT Cytochrome c biogenesis protein AOD69_07585 ENOG4105CRE cytochrome C AOD69_07590 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD69_07595 ENOG4105BZU Histidine kinase AOD69_07600 ENOG4108WBT adenosyltransferase AOD69_07615 ENOG4108SAX Membrane AOD69_07625 ENOG4105T7X AOD69_07630 ENOG4105C9U ATP-dependent DNA helicase RecQ AOD69_07635 ENOG4105I7S Abortive infection protein AOD69_07650 ENOG4107X2D transcriptional regulator, merr family AOD69_07655 ENOG4108S6Z Negative regulator of genetic competence AOD69_07680 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AOD69_07685 ENOG4107RB3 L-asparaginase AOD69_07720 ENOG4105S2F AOD69_07725 ENOG41065D1 AOD69_07755 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AOD69_07770 ENOG4105XXQ heptaprenyl diphosphate synthase component I AOD69_07780 ENOG4105EAH synthase AOD69_07800 ENOG4105CIH Imidazole acetol-phosphate transaminase AOD69_07805 ENOG41068YB TPR repeat-containing protein AOD69_07820 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AOD69_07825 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AOD69_07830 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AOD69_07860 ENOG4108JYZ YitT family AOD69_07865 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AOD69_07880 ENOG4105FJR Lmbe family AOD69_07885 ENOG4105CPK Glycosyl transferase (Group 1 AOD69_07925 ENOG4105DVT helicase AOD69_07930 ENOG4105YAC AOD69_07950 ENOG4105CSM endonuclease III AOD69_07960 ENOG4105BZ4 penicillin-binding protein AOD69_08010 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AOD69_08020 ENOG4105DVT helicase AOD69_08025 ENOG4105CTD carboxy-peptidase AOD69_08040 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AOD69_08050 ENOG4105C2W permease AOD69_08055 ENOG4105DHF Membrane AOD69_08060 ENOG410890F Dynamin family AOD69_08070 ENOG4108W0I acetyltransferase AOD69_08080 ENOG4105KHC sulfurtransferase AOD69_08095 ENOG4106032 Glutathionylspermidine synthase AOD69_08155 ENOG4105CPK Glycosyl transferase (Group 1 AOD69_08170 ENOG4108SZE gCN5-related N-acetyltransferase AOD69_08190 ENOG41081VK Ribonuclease AOD69_08255 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOD69_08265 ENOG4107RWR Sodium hydrogen exchanger AOD69_08270 ENOG4105CN5 Metallo-Beta-Lactamase AOD69_08275 ENOG4108Z5V transcriptional regulator, merr family AOD69_08285 ENOG4105H67 Protein of unknown function (DUF421) AOD69_08290 ENOG41080C8 DUF218 domain AOD69_08345 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AOD69_08355 ENOG4107R0U MotA TolQ exbB proton channel AOD69_08360 ENOG4105ER2 Ompa motb domain protein AOD69_08365 ENOG4107YTP response regulator receiver protein AOD69_08375 ENOG4105DD5 Flagellar motor switch protein AOD69_08390 ENOG4105BZU Histidine kinase AOD69_08410 ENOG4105E1Q flagellar hook-associated protein AOD69_08415 ENOG4105DTJ flagellar hook-associated protein AOD69_08440 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AOD69_08445 ENOG4108ZC9 flagellar basal-body rod protein flgc AOD69_08450 ENOG41075Z6 flagellar hook-basal body complex protein fliE AOD69_08455 ENOG4107U2N Flagellar M-ring protein AOD69_08465 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AOD69_08500 ENOG4105BZE flagellar hook protein, FlgE AOD69_08525 ENOG4105K64 Glycosyl transferase, family 2 AOD69_08555 ENOG4107TVC Glycosyl transferase, family 2 AOD69_08580 ENOG4105I03 Flagellin AOD69_08585 ENOG4105E4C Lytic transglycosylase catalytic AOD69_08600 ENOG4105DD5 Flagellar motor switch protein AOD69_08610 ENOG4105CN7 Flagellar biosynthetic protein FliP AOD69_08615 ENOG4105VS8 Flagellar biosynthetic protein fliq AOD69_08625 ENOG4105D00 flagellar biosynthetic protein flhB AOD69_08630 ENOG4105D7B Flagellar biosynthesis protein flha AOD69_08640 ENOG4105KTQ flagellar basal-body rod protein AOD69_08645 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOD69_08670 ENOG4108RZE Tetr family transcriptional regulator AOD69_08690 ENOG4105KAC Antibiotic biosynthesis monooxygenase AOD69_08715 ENOG4105DUM transcriptional regulator, lysR family AOD69_08720 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOD69_08725 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOD69_08730 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AOD69_08735 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AOD69_08770 ENOG4105CVJ phosphoglycerate mutase AOD69_08800 ENOG4105CAQ asparagine synthetase AOD69_08820 ENOG4105PGM cation diffusion facilitator family transporter AOD69_08830 ENOG4105DRR Transcriptional regulator, GntR family AOD69_08835 ENOG4108UZ3 Transporter AOD69_08840 ENOG4105CKI cobalamin synthesis protein AOD69_08845 ENOG4108PJD permease AOD69_08860 ENOG4105DFD Na H antiporter AOD69_08865 ENOG4105C9Q fumarate hydratase class II AOD69_08895 ENOG4105EC3 peptidase S51, dipeptidase E AOD69_08915 ENOG4107QIV Cytochrome c biogenesis protein AOD69_08950 ENOG4106BRA Membrane AOD69_08985 ENOG4105CJ1 ABC, transporter AOD69_09005 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AOD69_09020 ENOG4105C6K Malic enzyme AOD69_09090 ENOG4105FVX AOD69_09130 ENOG4105CSR polyphosphate kinase 2 AOD69_09150 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AOD69_09165 ENOG4105EU0 Major facilitator Superfamily AOD69_09170 ENOG4105C6T cysteine synthase AOD69_09190 ENOG4105C8J )-transporter AOD69_09200 ENOG4105X5K response regulator receiver protein AOD69_09205 ENOG4105H67 Protein of unknown function (DUF421) AOD69_09220 ENOG4106KE4 Dehydrogenase AOD69_09235 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AOD69_09240 ENOG4105CHR reductase AOD69_09245 ENOG4105CM2 brancheD-chain amino acid aminotransferase AOD69_09250 ENOG4105C7K acetolactate synthase AOD69_09255 ENOG4108ZP8 Acetolactate synthase small subunit AOD69_09260 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AOD69_09270 ENOG4105C7B Threonine dehydratase AOD69_09295 ENOG4105C6X Major Facilitator AOD69_09300 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AOD69_09310 ENOG4105DY9 regulatoR AOD69_09315 ENOG4105CYC Transferase AOD69_09335 ENOG4105F6J Alpha beta hydrolase fold AOD69_09340 ENOG4108J59 Extracellular solute-binding protein, family 5 AOD69_09370 ENOG41068WN AOD69_09390 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AOD69_09395 ENOG4105C72 UPF0176 protein AOD69_09405 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AOD69_09440 ENOG4107RHR regulatoR AOD69_09450 ENOG4105D9N nucleoside AOD69_09455 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AOD69_09490 ENOG4107RAQ aminopeptidase AOD69_09495 ENOG4107STQ Multicopper oxidase AOD69_09540 ENOG4108T5E Copper resistance protein AOD69_09545 ENOG4105KTB nuclear export factor GLE1 AOD69_09555 ENOG4107RT3 EamA-like transporter family AOD69_09560 ENOG4105GZI Transcriptional regulator AOD69_09565 ENOG4108Z40 Transcriptional regulator AOD69_09570 ENOG4107ZXU DSBA oxidoreductase AOD69_09575 ENOG4108TVJ Nitroreductase AOD69_09585 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AOD69_09590 ENOG4106F5Q Membrane AOD69_09595 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOD69_09605 ENOG4105CKI cobalamin synthesis protein AOD69_09625 ENOG4108Z7G MaoC domain protein dehydratase AOD69_09630 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOD69_09640 ENOG4105C0Z ABC transporter AOD69_09645 ENOG4108IV0 ABC, transporter AOD69_09650 ENOG4105C32 Amino acid ABC transporter (Permease) AOD69_09660 ENOG4105SKE transcriptional Regulator LysR family AOD69_09670 ENOG4105MDS 4-oxalocrotonate tautomerase AOD69_09680 ENOG4105YGB Transcriptional regulator AOD69_09690 ENOG4105C4M (Ubiquinol oxidase) subunit I AOD69_09695 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AOD69_09700 ENOG4108JJ9 ABC, transporter AOD69_09705 ENOG4108JJ8 (ABC) transporter AOD69_09750 ENOG4105BZ1 (ABC) transporter AOD69_09755 ENOG4105BZ1 (ABC) transporter AOD69_09760 ENOG4105EFI regulatoR AOD69_09765 ENOG4105BZU Histidine kinase AOD69_09785 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AOD69_09790 ENOG4108ZJ4 polysaccharide deacetylase AOD69_09810 ENOG4105D6E homoserine dehydrogenase AOD69_09835 ENOG4108KGH TRANSCRIPTIONal AOD69_09845 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD69_09850 ENOG4105BZU Histidine kinase AOD69_09855 ENOG4107VMI polysaccharide deacetylase AOD69_09865 ENOG4105KT7 mgtC SapB transporter AOD69_09870 ENOG4105VRR gCN5-related N-acetyltransferase AOD69_09880 ENOG4105DUU IucA IucC family protein AOD69_09885 ENOG4105CEY Amp-dependent synthetase and ligase AOD69_09900 ENOG4108WBH protein TIM barrel AOD69_09905 ENOG4105YWU small acid-soluble spore protein AOD69_09915 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AOD69_09965 ENOG4105KRN Transcriptional regulator, abrb family AOD69_09975 ENOG4105YVS arsR family transcriptional regulator AOD69_09980 ENOG4107SET aldo keto reductase AOD69_09985 ENOG4107XZQ multidrug resistance protein AOD69_10010 ENOG4105C8Q Methyl-accepting chemotaxis AOD69_10030 ENOG4108K88 Membrane AOD69_10035 ENOG4108WPJ Ferritin-like domain AOD69_10050 ENOG4105DEN Luciferase family AOD69_10070 ENOG4107QM2 Aldo Keto reductase AOD69_10075 ENOG4105CKI cobalamin synthesis protein AOD69_10140 ENOG4105DSE periplasmic solute binding protein AOD69_10150 ENOG4105K4T epimerase AOD69_10160 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AOD69_10185 ENOG4105CVJ phosphoglycerate mutase AOD69_10205 ENOG4107T5V SNARE associated Golgi AOD69_10220 ENOG4108PJD permease AOD69_10230 ENOG4108S4H thioesterase Superfamily protein AOD69_10235 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOD69_10255 ENOG4105SXS Protein of unknown function (DUF456) AOD69_10260 ENOG4105C37 (CBS) domain AOD69_10280 ENOG4108Z7R Chaperone CsaA AOD69_10300 ENOG4108ZRV stage ii sporulation protein p AOD69_10310 ENOG4108VXD carboxy-peptidase AOD69_10320 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AOD69_10345 ENOG4108X4Q Hydrolase AOD69_10355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AOD69_10360 ENOG4107RBS Methyltransferase AOD69_10375 ENOG41087PP glycosyltransferase MGT family AOD69_10380 ENOG4108JYZ YitT family AOD69_10385 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AOD69_10410 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AOD69_10460 ENOG4105KBJ sporulation protein ytfj AOD69_10485 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AOD69_10505 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AOD69_10510 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase AOD69_10520 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AOD69_10525 ENOG4105EMN RNA polymerase sigma factor AOD69_10550 ENOG4108V06 Glutathione peroxidase AOD69_10565 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOD69_10585 ENOG4108IUE nitrate reductase beta subunit AOD69_10590 ENOG4105R3A Nitrate reductase AOD69_10615 ENOG4107V6Q Cyclic nucleotide-binding domain AOD69_10620 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AOD69_10625 ENOG4105D06 uba thif-type nad fad binding protein AOD69_10630 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOD69_10635 ENOG4108ZAF Molybdopterin AOD69_10660 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AOD69_10665 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AOD69_10670 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AOD69_10675 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AOD69_10680 ENOG4108IFG nitrite reductase, (NAD(P)H) AOD69_10685 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AOD69_10720 ENOG4105MCT stage V sporulation protein S AOD69_10735 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AOD69_10755 ENOG4105C5H ABC transporter AOD69_10770 ENOG4108UUM single-stranded DNA-binding protein AOD69_10785 ENOG41061H0 Monooxygenase AOD69_10805 ENOG4107YX5 Pfam:DUF548 AOD69_10810 ENOG4105C75 arginyL-tRNA synthetase AOD69_10835 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AOD69_10850 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AOD69_10855 ENOG4105C5S asparaginyl-tRNA synthetase AOD69_10875 ENOG4105EC2 ftsk spoIIIe AOD69_10970 ENOG4105BZW Glycerate kinase AOD69_10975 ENOG4107QPK )-transporter AOD69_10980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD69_10985 ENOG41062D9 Histidine kinase AOD69_11000 ENOG4105C8J )-transporter AOD69_11020 ENOG4107XGZ Hydrolase AOD69_11025 ENOG4105CY2 Citrate transporter AOD69_11030 ENOG4105C0A alcohol dehydrogenase AOD69_11045 ENOG4105KD7 acetyltransferase AOD69_11075 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AOD69_11095 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AOD69_11110 ENOG4107RVG penicillin-binding protein AOD69_11115 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AOD69_11120 ENOG4105E9Q Acyl-transferase AOD69_11125 ENOG4108UT2 hemolysin iii AOD69_11135 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AOD69_11145 ENOG4108RCR degv family AOD69_11150 ENOG4105E8R UPF0173 metal-dependent hydrolase AOD69_11155 ENOG4108KF3 Electron transport protein SCO1 SenC AOD69_11160 ENOG4107Y70 Heat shock protein AOD69_11165 ENOG4105CAQ asparagine synthetase AOD69_11185 ENOG4108MES Periplasmic binding protein AOD69_11190 ENOG4105F0I Aminotransferase AOD69_11225 ENOG4105D8X mechanosensitive ion channel AOD69_11230 ENOG4105BZU Histidine kinase AOD69_11235 ENOG4105WH1 Two component transcriptional regulator luxr family AOD69_11245 ENOG4106KNT transcriptional regulator AOD69_11280 ENOG4105CMG Carbohydrate kinase AOD69_11285 ENOG4105CMG Carbohydrate kinase AOD69_11315 ENOG4108IJ8 ABC transporter AOD69_11320 ENOG4105E90 ABC transporter AOD69_11355 ENOG4105C37 (CBS) domain AOD69_11380 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOD69_11395 ENOG4107S4Y M20 DapE family protein YgeY AOD69_11400 ENOG4108TSC N-acetyltransferase AOD69_11405 ENOG4108JUB Transcriptional regulator AOD69_11410 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AOD69_11450 ENOG4108N23 SpoOM-related protein AOD69_11455 ENOG410841Q phosphoesterase PA-phosphatase related protein AOD69_11465 ENOG4105SZ6 Thioredoxin AOD69_11480 ENOG4108IBT Inherit from COG: transposase AOD69_11580 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOD69_11620 ENOG4105BZ4 penicillin-binding protein AOD69_11630 ENOG4105CZM Major Facilitator AOD69_11635 ENOG4105W8X HesB YadR YfhF-family protein AOD69_11645 ENOG4105DXD 2-methylcitrate dehydratase AOD69_11650 ENOG4105CR4 methylisocitrate lyase AOD69_11655 ENOG4105C1G acyl-Coa dehydrogenase AOD69_11660 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AOD69_11670 ENOG4105N14 lysine exporter protein LysE YggA AOD69_11675 ENOG4105E39 Enoyl-CoA hydratase AOD69_11690 ENOG4107RFY SbcCD D subunit AOD69_11695 ENOG4105EYH Exonuclease AOD69_11725 ENOG4105FCD Major Facilitator AOD69_11730 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AOD69_11735 ENOG4105E4F Isochorismate synthase AOD69_11740 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AOD69_11745 ENOG4105WQI isochorismatase AOD69_11750 ENOG4105CEY Amp-dependent synthetase and ligase AOD69_11755 ENOG4105WQT MbtH domain protein AOD69_11760 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD69_11775 ENOG4105K70 DNA-binding protein AOD69_11795 ENOG4105BZG amino acid carrier protein AOD69_11820 ENOG4105FE9 pseudouridine synthase AOD69_11825 ENOG4105C22 threonyL-tRNA synthetase AOD69_11840 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AOD69_11865 ENOG4108D32 Methyltransferase AOD69_11895 ENOG41081I9 integral membrane protein AOD69_11910 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AOD69_11920 ENOG4105EYF MMPL domain protein AOD69_11945 ENOG4105WCN acetyltransferase AOD69_11975 ENOG4105C1Q protoporphyrinogen oxidase AOD69_11985 ENOG41068WN AOD69_11995 ENOG4105VEQ Cold shock protein AOD69_12015 ENOG410667J hydrolase AOD69_12060 ENOG4107V2S Transcriptional regulator AOD69_12065 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AOD69_12080 ENOG4105DND Transcriptional regulator AOD69_12085 ENOG4108RPX mosc domain containing protein AOD69_12100 ENOG4105BZ1 (ABC) transporter AOD69_12105 ENOG4105BZ1 (ABC) transporter AOD69_12125 ENOG4108JCI Transcriptional regulator AOD69_12155 ENOG4108KPJ rna polymerase sigma factor AOD69_12180 ENOG4105F32 YngK protein AOD69_12205 ENOG4105RD7 BadF BadG BcrA BcrD AOD69_12215 ENOG4107STF Involved in phosphonate degradation (By similarity) AOD69_12235 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AOD69_12250 ENOG4105C1J atp-dependent rna helicase AOD69_12265 ENOG4108RZE Tetr family transcriptional regulator AOD69_12285 ENOG41088CC tellurite resistance protein tehB AOD69_12295 ENOG4108I0C methyltransferase AOD69_12300 ENOG4107RA9 decarboxylase AOD69_12305 ENOG41090HR transcriptional regulator AOD69_12345 ENOG4105CIN aminoacyl-histidine dipeptidase AOD69_12370 ENOG4107RF6 penicillin-binding protein AOD69_12385 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AOD69_12390 ENOG4105ETE Transcriptional regulator (LacI family AOD69_12395 ENOG4105IE8 Alpha-ketoglutarate permease AOD69_12400 ENOG4105CK5 oxidoreductase AOD69_12425 ENOG4105D2N Aldolase AOD69_12430 ENOG4105DH8 myo-inositol catabolism AOD69_12445 ENOG4105CGH 5'-nucleotidase AOD69_12455 ENOG4105CGH 5'-nucleotidase AOD69_12470 ENOG4105VZ8 Transcriptional regulator AOD69_12485 ENOG4108VXD carboxy-peptidase AOD69_12505 ENOG41067SE Tetr family transcriptional regulator AOD69_12510 ENOG4105C5H ABC transporter AOD69_12520 ENOG4105BZU Histidine kinase AOD69_12530 ENOG4106ANW SMI1_KNR4 AOD69_12535 ENOG4105CEP NADH dehydrogenase AOD69_12540 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AOD69_12555 ENOG4105CJ1 ABC, transporter AOD69_12565 ENOG4107Z3H Transcriptional regulator, TetR family AOD69_12580 ENOG4105C1G acyl-Coa dehydrogenase AOD69_12585 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AOD69_12590 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AOD69_12595 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AOD69_12600 ENOG4105E39 Enoyl-CoA hydratase AOD69_12605 ENOG4107QX3 carboxylase AOD69_12610 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AOD69_12620 ENOG4105WCN acetyltransferase AOD69_12625 ENOG4105DBI uridine monophosphokinase AOD69_12660 ENOG4105T9C HD domain AOD69_12670 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AOD69_12710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOD69_12710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOD69_12725 ENOG4105FQP Beta-lactamase AOD69_12735 ENOG4107Y80 Major Facilitator superfamily AOD69_12755 ENOG4105CUV Homoserine Kinase AOD69_12790 ENOG4105CPQ Dehydrogenase AOD69_12805 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOD69_12810 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOD69_12905 ENOG4105ETU transcriptional activator (TenA AOD69_13015 ENOG410667J hydrolase AOD69_13025 ENOG4105BZU Histidine kinase AOD69_13030 ENOG4107RF6 penicillin-binding protein AOD69_13050 ENOG4108JJB ABC transporter AOD69_13060 ENOG4108HGU Histidine kinase AOD69_13075 ENOG4105CB2 alcohol dehydrogenase AOD69_13080 ENOG4105CJN penicillin-binding protein AOD69_13090 ENOG4105FQP Beta-lactamase AOD69_13125 ENOG4108V4B ThiJ pfpI AOD69_13155 ENOG4107Y80 Major Facilitator superfamily AOD69_13170 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AOD69_13190 ENOG4107Y9U Membrane AOD69_13225 ENOG4105FCD Major Facilitator AOD69_13240 ENOG4105E09 nadh pyrophosphatase AOD69_13245 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AOD69_13250 ENOG4108Z4K mutator MutT protein AOD69_13285 ENOG4108XI2 Domain of unknown function (DUF1963) AOD69_13315 ENOG4108NRW Phospholipase, patatin family AOD69_13320 ENOG4105KWG Pfam:DUF1696 AOD69_13355 ENOG4105PKS Excinuclease abc c subunit domain protein AOD69_13395 ENOG4107VFR oxidoreductase AOD69_13420 ENOG4105PAD Hydrolase AOD69_13440 ENOG4105DY8 decarboxylase AOD69_13455 ENOG4108IUM Glycogen debranching enzyme AOD69_13480 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AOD69_13490 ENOG4105FDR Membrane AOD69_13525 ENOG4108V3A UPF0421 protein AOD69_13545 ENOG4105MSI germination protein ypeb AOD69_13565 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AOD69_13570 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AOD69_13575 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AOD69_13580 ENOG4107Z3H Transcriptional regulator, TetR family AOD69_13610 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AOD69_13630 ENOG4105E98 transcriptional regulator DeoR family AOD69_13650 ENOG41062ES Transcriptional regulator AOD69_13670 ENOG4107QKR Dehydrogenase AOD69_13680 ENOG4107RUY (E1 component), alpha subunit AOD69_13690 ENOG4105E1F short-chain dehydrogenase reductase AOD69_13695 ENOG4105RHY Pfam:UPF0157 AOD69_13730 ENOG4107SQ8 Glycine betaine AOD69_13735 ENOG4108IJ7 Glycine betaine AOD69_13760 ENOG4105E66 phosphoriboisomerase A AOD69_13765 ENOG41082BV acetyltransferase AOD69_13770 ENOG4108M1A Chitin-binding protein AOD69_13815 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AOD69_13865 ENOG4105EEM helicase AOD69_13885 ENOG4105C9U ATP-dependent DNA helicase RecQ AOD69_13940 ENOG4108M1A Chitin-binding protein AOD69_13955 ENOG4105BZG amino acid carrier protein AOD69_13960 ENOG4105C26 Dehydrogenase AOD69_13965 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AOD69_13970 ENOG4105CTU Proline racemase AOD69_13975 ENOG4105CTU Proline racemase AOD69_13980 ENOG41080HI glycine oxidase AOD69_14020 ENOG4107T5V SNARE associated Golgi AOD69_14035 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AOD69_14040 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AOD69_14055 ENOG4105DTQ mandelate racemase muconate lactonizing AOD69_14095 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AOD69_14100 ENOG4105BZU Histidine kinase AOD69_14105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD69_14145 ENOG4105EPR degv family AOD69_14185 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AOD69_14190 ENOG4106K7D Major facilitator family transporter AOD69_14210 ENOG4107BMA Transglycosylase associated protein AOD69_14225 ENOG41089UC methyltransferase, type 11 AOD69_14260 ENOG4105CHM Aminotransferase AOD69_14295 ENOG4105DVE abc transporter atp-binding protein AOD69_14345 ENOG4105C02 permease AOD69_14360 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AOD69_14365 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AOD69_14370 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AOD69_14395 ENOG4105E09 nadh pyrophosphatase AOD69_14415 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AOD69_14465 ENOG4107VC0 DNA alkylation repair enzyme AOD69_14475 ENOG4107VMI polysaccharide deacetylase AOD69_14485 ENOG4108ZCF integral membrane protein AOD69_14490 ENOG4105E0M Sulfatase AOD69_14495 ENOG4105C5H ABC transporter AOD69_14505 ENOG4105EYF MMPL domain protein AOD69_14510 ENOG4105EYF MMPL domain protein AOD69_14515 ENOG4105EYF MMPL domain protein AOD69_14520 ENOG41082JN Transcriptional regulator AOD69_14540 ENOG4105CIH Imidazole acetol-phosphate transaminase AOD69_14545 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AOD69_14550 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AOD69_14585 ENOG41069ER domain protein AOD69_14595 ENOG4105EMN RNA polymerase sigma factor AOD69_14620 ENOG4105D4B ABC, transporter AOD69_14630 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AOD69_14640 ENOG4105DKT Transcriptional regulator AOD69_14655 ENOG41061GT Aldolase AOD69_14675 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AOD69_14705 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AOD69_14710 ENOG4105II7 pyrroline-5-carboxylate reductase AOD69_14720 ENOG4107258 Transcriptional regulator AOD69_14730 ENOG4105E0Y RtcB Protein AOD69_14735 ENOG4105ECK Fatty Acid Desaturase AOD69_14740 ENOG4105G6Z alkaline phosphatase AOD69_14750 ENOG4105VMP Transcriptional regulator AOD69_14765 ENOG41090T1 Membrane AOD69_14775 ENOG4108WCX response regulator AOD69_14785 ENOG41068WN AOD69_14810 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOD69_14835 ENOG4105CKK Glycosyl transferase, family 2 AOD69_14860 ENOG4105CKK Glycosyl transferase, family 2 AOD69_14870 ENOG4105C8Y Acetylornithine aminotransferase AOD69_14910 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOD69_14920 ENOG4108TVJ Nitroreductase AOD69_14925 ENOG4105FS7 Transcriptional regulator AOD69_14960 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOD69_14970 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AOD69_15000 ENOG4108XET gCN5-related N-acetyltransferase AOD69_15080 ENOG410635A Membrane AOD69_15085 ENOG4105KNA -acetyltransferase AOD69_15090 ENOG4108IQI permease AOD69_15100 ENOG4105F1N DNA alkylation repair AOD69_15140 ENOG4107RF6 penicillin-binding protein AOD69_15150 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AOD69_15190 ENOG4105P4J Allophanate hydrolase, subunit 1 AOD69_15195 ENOG4107258 Transcriptional regulator AOD69_15205 ENOG4106N3A copper homeostasis protein cutc AOD69_15210 ENOG4108ZRV stage ii sporulation protein p AOD69_15215 ENOG4108ZHR arsR family transcriptional regulator AOD69_15225 ENOG4105FDT acyl-CoA dehydrogenase AOD69_15245 ENOG4105DWD nucleoside recognition domain protein AOD69_15275 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AOD69_15340 ENOG4105E2A Dehydrogenase AOD69_15355 ENOG4108IJ0 Aspartate ammonia-lyase AOD69_15360 ENOG4105HDK L-asparaginase AOD69_15365 ENOG4108IMY Transcriptional regulator AOD69_15375 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AOD69_15380 ENOG4105CUB amino acid AOD69_15390 ENOG4105II7 pyrroline-5-carboxylate reductase AOD69_15400 ENOG4105C6K Malic enzyme AOD69_15410 ENOG4108NHD germination protein AOD69_15415 ENOG4108NHD germination protein AOD69_15420 ENOG4108Q8B Spore germination protein AOD69_15440 ENOG4105CSV Glutaminase AOD69_15470 ENOG4105CGH 5'-nucleotidase AOD69_15475 ENOG4105CH6 catalase AOD69_15485 ENOG4105CHJ isochorismatase hydrolase AOD69_15550 ENOG4108606 TspO/MBR family AOD69_15555 ENOG4105CVP deoxyribo-dipyrimidine photolyase AOD69_15570 ENOG4108TWJ NADH dehydrogenase subunit 5 AOD69_15575 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AOD69_15585 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AOD69_15590 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AOD69_15595 ENOG4105DSE periplasmic solute binding protein AOD69_15600 ENOG4105CC5 ABC transporter AOD69_15605 ENOG4105DIK (ABC) transporter AOD69_15635 ENOG4105D6J arsenicaL-resistance protein AOD69_15640 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AOD69_15645 ENOG41085FC arsR family transcriptional regulator AOD69_15660 ENOG4105F7F Chaperone AOD69_15670 ENOG4105CHR reductase AOD69_15675 ENOG4108YXU transcriptional regulator AsnC family AOD69_15750 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AOD69_15760 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD69_15770 ENOG4105IIP Membrane AOD69_15785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD69_15790 ENOG41062D9 Histidine kinase AOD69_15820 ENOG4105K6H D-cysteine desulfhydrase AOD69_15845 ENOG4105VZ8 Transcriptional regulator AOD69_15860 ENOG4108NNI Beta-lactamase domain-containing protein AOD69_15865 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AOD69_15875 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOD69_15880 ENOG4105JQZ Methyltransferase AOD69_15895 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AOD69_15900 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AOD69_15920 ENOG4105BZU Histidine kinase AOD69_15935 ENOG4108U05 Transcriptional regulator AOD69_15950 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AOD69_15955 ENOG4105DJB Major Facilitator Superfamily AOD69_15960 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AOD69_15965 ENOG4107QR9 Iron-sulfur cluster binding protein AOD69_15975 ENOG4106P55 Transcriptional regulator AOD69_15985 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AOD69_16020 ENOG4105TRI Hydrolase AOD69_16055 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AOD69_16085 ENOG4107QJQ Mate efflux family protein AOD69_16100 ENOG4105EQ0 Major Facilitator superfamily AOD69_16105 ENOG4108JGH Tetr family transcriptional regulator AOD69_16120 ENOG4105C44 Serine transporter AOD69_16125 ENOG4105EJQ L-serine dehydratase AOD69_16140 ENOG4108JPW Aminotransferase AOD69_16155 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AOD69_16165 ENOG4105DVH amino acid AOD69_16180 ENOG4108JQ1 Dehydrogenase AOD69_16200 ENOG4108AEY RNA polymerase sigma factor AOD69_16215 ENOG41082W1 Cupin 2, conserved barrel domain protein AOD69_16225 ENOG410874W AraC family transcriptional regulator AOD69_16240 ENOG4105HIR S-layer domain protein AOD69_16280 ENOG4108ISG Major Facilitator AOD69_16290 ENOG4107MII Sugar-specific transcriptional regulator TrmB AOD69_16295 ENOG4105CZM Major Facilitator AOD69_16315 ENOG4105DA5 (ABC) transporter AOD69_16320 ENOG41069JR AOD69_16330 ENOG4105RXJ AOD69_16335 ENOG4105KPY Small multidrug resistance protein AOD69_16340 ENOG4105KBX Transcriptional regulator, TetR family AOD69_16355 ENOG4105CRW Short chain fatty acid transporter AOD69_16365 ENOG4105DYS nad(p)h dehydrogenase (quinone) AOD69_16395 ENOG4108JJB ABC transporter AOD69_16400 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AOD69_16425 ENOG4108K8S endonuclease I AOD69_16440 ENOG41067QW Transcriptional regulator AOD69_16450 ENOG4108Z66 YbaK ebsC protein AOD69_16455 ENOG4105CUT histidyl-tRNA synthetase AOD69_16470 ENOG4105KVH Transcriptional regulator AOD69_16475 ENOG4108RCM Nitroreductase AOD69_16495 ENOG4108PSK reductase AOD69_16505 ENOG4105CJ1 ABC, transporter AOD69_16565 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AOD69_16570 ENOG4105DKQ ROK family AOD69_16575 ENOG4106UW1 Major Facilitator superfamily AOD69_16580 ENOG4108UW5 maltose o-acetyltransferase AOD69_16595 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AOD69_16600 ENOG4105C31 Tryptophanyl-tRNA synthetase AOD69_16605 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AOD69_16630 ENOG4105DMQ Methyltransferase AOD69_16640 ENOG4105EV4 Multidrug resistance protein mdtH AOD69_16670 ENOG4105C37 (CBS) domain AOD69_16685 ENOG4105DDN Pentapeptide repeat-containing protein AOD69_16690 ENOG4105XDF Protein of unknown function (DUF1272) AOD69_16695 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AOD69_16700 ENOG4105CMG Carbohydrate kinase AOD69_16705 ENOG4105C6Z Gluconate AOD69_16710 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AOD69_16725 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AOD69_16730 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AOD69_16735 ENOG4105CIS alcohol dehydrogenase AOD69_16740 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AOD69_16760 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AOD69_16765 ENOG4105D4Y metalloprotease AOD69_16785 ENOG4105CV8 reductase AOD69_16790 ENOG4105F27 Major Facilitator AOD69_16805 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AOD69_16810 ENOG4105C44 Serine transporter AOD69_16845 ENOG4105KVH Transcriptional regulator AOD69_16850 ENOG4108TZY GntR Family Transcriptional Regulator AOD69_16860 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AOD69_16865 ENOG4105KVH Transcriptional regulator AOD69_16870 ENOG4105KVH Transcriptional regulator AOD69_16905 ENOG4105JAB phenazine biosynthesis protein, phzf family AOD69_16915 ENOG4105CHR reductase AOD69_16935 ENOG4105KVH Transcriptional regulator AOD69_17005 ENOG4105KAF membrAne AOD69_17030 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AOD69_17045 ENOG4107YXZ hydrolase, family 25 AOD69_17070 ENOG4105ED2 Beta-lactamase AOD69_17080 ENOG4105H3G oxidoreductase AOD69_17155 ENOG4108TN2 lmbE family AOD69_17165 ENOG4107R3E Citrate transporter AOD69_17185 ENOG4108MES Periplasmic binding protein AOD69_17195 ENOG4105EHG Permease protein AOD69_17200 ENOG4105DQ5 transport system permease protein AOD69_17205 ENOG4105NX3 Membrane AOD69_17210 ENOG4107ZY0 Phenazine biosynthesis-like protein AOD69_17230 ENOG4107CUJ Protein of unknown function (DUF2690) AOD69_17240 ENOG4107V2S Transcriptional regulator AOD69_17260 ENOG4105C98 muts2 protein AOD69_17270 ENOG4105E5K Alpha-amylase AOD69_17275 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AOD69_17280 ENOG4105DPN Oligoendopeptidase f AOD69_17285 ENOG4108A04 Beta-lactamase AOD69_17315 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AOD69_17340 ENOG41082BM Transcriptional regulator, arsr family AOD69_17345 ENOG4105CIS alcohol dehydrogenase AOD69_17370 ENOG4105RHY Pfam:UPF0157 AOD69_17380 ENOG4105C09 Bile acid AOD69_17385 ENOG4105CQB FAD linked oxidase domain protein AOD69_17410 ENOG4108UT6 Transferase hexapeptide repeat containing protein AOD69_17420 ENOG4105K64 Glycosyl transferase, family 2 AOD69_17425 ENOG4105E39 Enoyl-CoA hydratase AOD69_17435 ENOG4105KT7 mgtC SapB transporter AOD69_17445 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOD69_17450 ENOG41073R8 VanW family AOD69_17460 ENOG4108R1P AOD69_17480 ENOG4105VEQ Cold shock protein AOD69_17500 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AOD69_17520 ENOG410904N short-chain dehydrogenase reductase AOD69_17530 ENOG4106IQC argininosuccinate lyase AOD69_17545 ENOG4108IA2 Sodium pantothenate symporter AOD69_17555 ENOG4105C26 Dehydrogenase AOD69_17560 ENOG4105CHR reductase AOD69_17570 ENOG4105EWU Squalene--hopene cyclase AOD69_17580 ENOG4105FR1 rard protein AOD69_17585 ENOG410696E Membrane AOD69_17600 ENOG4105D1F ATP-binding protein AOD69_17610 ENOG4108ZAF Molybdopterin AOD69_17615 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOD69_17620 ENOG4105D06 uba thif-type nad fad binding protein AOD69_17625 ENOG4105TMB Formate nitrite transporter AOD69_17635 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AOD69_17640 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AOD69_17650 ENOG4108JB9 formate dehydrogenase AOD69_17660 ENOG4105E1K spore germination protein AOD69_17720 ENOG4107QJT sodium dicarboxylate symporter AOD69_17725 ENOG4108KGH TRANSCRIPTIONal AOD69_17735 ENOG4105EMN RNA polymerase sigma factor AOD69_17760 ENOG4105CIG ABC transporter AOD69_17770 ENOG4105D9R oxidoreductase AOD69_17780 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOD69_17790 ENOG4105K4P CoA-binding domain protein AOD69_17795 ENOG4105C0H protease AOD69_17800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD69_17810 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AOD69_17815 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AOD69_17820 ENOG4105W8X HesB YadR YfhF-family protein AOD69_17850 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AOD69_17855 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AOD69_17865 ENOG4108JJA ABC, transporter AOD69_17870 ENOG4108I0Z Aconitate hydratase AOD69_17900 ENOG4105E5W Transporter AOD69_17910 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOD69_17930 ENOG4107F3J Amp-dependent synthetase and ligase AOD69_17935 ENOG4107ZYJ bioY protein AOD69_17940 ENOG4105CEY Amp-dependent synthetase and ligase AOD69_17985 ENOG4107AYK membrAne AOD69_17995 ENOG4105BZU Histidine kinase AOD69_18000 ENOG4105FBA Phospholipase Carboxylesterase AOD69_18005 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AOD69_18010 ENOG4105CK7 Sodium proline symporter AOD69_18015 ENOG4105CBC glutamate synthase AOD69_18020 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AOD69_18025 ENOG4108VJ1 Transcriptional regulator (CarD family AOD69_18030 ENOG4108903 Formimidoylglutamase AOD69_18055 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AOD69_18115 ENOG4107QIV Cytochrome c biogenesis protein AOD69_18125 ENOG4107RSM transcriptional regulator AOD69_18130 ENOG4105VAW lrga family AOD69_18135 ENOG41067MG lrgb family AOD69_18160 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AOD69_18175 ENOG4105BZ1 (ABC) transporter AOD69_18180 ENOG4105BZ1 (ABC) transporter AOD69_18200 ENOG4105D7V transposase AOD69_18220 ENOG4105D5T phosphonate abc transporter AOD69_18235 ENOG4105CGH 5'-nucleotidase AOD69_18245 ENOG4108SVB resolvase AOD69_18265 ENOG4105K7K Transcriptional regulator AOD69_18300 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AOD69_18305 ENOG4105XSJ toxin secretion phage lysis holin AOD69_18515 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) AOD69_18620 ENOG4105C5F glutamine synthetase AOD69_18625 ENOG4105KV4 Transcriptional regulator AOD69_18630 ENOG4105CXI aluminum resistance protein AOD69_18640 ENOG4105EN6 Membrane AOD69_18645 ENOG4106F1P AAA ATPase, central domain protein AOD69_18675 ENOG41069ER domain protein AOD69_18680 ENOG4105DM4 PTS System AOD69_18685 ENOG4105DE4 1-phosphofructokinase AOD69_18690 ENOG4105E98 transcriptional regulator DeoR family AOD69_18700 ENOG4108SJC Membrane AOD69_18715 ENOG4105C85 amino acid AOD69_18730 ENOG4105TMB Formate nitrite transporter AOD69_18735 ENOG4105K70 DNA-binding protein AOD69_18740 ENOG4105C59 p-type ATPase AOD69_18745 ENOG410681U heavy metal transport detoxification protein AOD69_18750 ENOG4105VPX protein, conserved in bacteria AOD69_18760 ENOG4105NIV Esterase AOD69_18765 ENOG4105E0A ABC, transporter AOD69_18790 ENOG4105CGK Exodeoxyribonuclease III AOD69_18800 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AOD69_18805 ENOG4105D03 DNA-3-methyladenine glycosylase II AOD69_18835 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AOD69_18840 ENOG4105BZU Histidine kinase AOD69_18860 ENOG41067MG lrgb family AOD69_18875 ENOG4107TTQ Alpha beta hydrolase fold AOD69_18880 ENOG4107YEI lmbE family AOD69_18900 ENOG4105F0V Cell wall hydrolase AOD69_18905 ENOG4107R6R udp-galactopyranose mutase AOD69_18910 ENOG4105E0M Sulfatase AOD69_18915 ENOG410890F Dynamin family AOD69_18925 ENOG4107QHE Choloylglycine hydrolase AOD69_18950 ENOG4105DA5 (ABC) transporter AOD69_18975 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AOD69_18980 ENOG4105DQU oxidoreductase, subunit beta AOD69_18985 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AOD69_18990 ENOG4108IGT Dipeptidase AOD69_18995 ENOG4105MCT stage V sporulation protein S AOD69_19000 ENOG4105D48 metallophosphoesterase AOD69_19025 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AOD69_19040 ENOG4105XZV Protein of unknown function (DUF3243) AOD69_19045 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AOD69_19065 ENOG4105UIB (ABC) transporter AOD69_19070 ENOG4105UIB (ABC) transporter AOD69_19075 ENOG4108JQ9 ABC transporter AOD69_19080 ENOG4105DIH basic membrane AOD69_19085 ENOG4105FDP GntR family transcriptional regulator AOD69_19090 ENOG4107QZI cell division protein FtsK AOD69_19100 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AOD69_19115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AOD69_19125 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AOD69_19130 ENOG4108S0H Dipicolinic acid synthetase, b subunit AOD69_19135 ENOG4105E35 Dipicolinate synthase subunit A AOD69_19145 ENOG4105C1V Peptidase, M16 AOD69_19165 ENOG4105DTN riboflavin biosynthesis protein ribF AOD69_19170 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AOD69_19180 ENOG4105W7A Protein of unknown function (DUF503) AOD69_19190 ENOG4105VHM ribosomal protein AOD69_19195 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AOD69_19200 ENOG4105CHV Transcription elongation factor NusA AOD69_19210 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AOD69_19220 ENOG4105DZP Membrane-associated zinc metalloprotease AOD69_19225 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AOD69_19230 ENOG4105KNE Phosphatidate cytidylyltransferase AOD69_19235 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AOD69_19275 ENOG4108HE4 integrase family AOD69_19285 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AOD69_19295 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AOD69_19310 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AOD69_19335 ENOG4105VB6 UPF0109 protein AOD69_19355 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AOD69_19360 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AOD69_19375 ENOG4105CHR reductase AOD69_19380 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AOD69_19395 ENOG4105CB5 ATP-dependent DNA helicase recG AOD69_19400 ENOG4105DP4 dak2 domain fusion protein ylov AOD69_19405 ENOG4108ZAA Alkaline-shock protein AOD69_19420 ENOG4105FJ0 thiamine AOD69_19425 ENOG4105DJV ribulose-phosphate 3-epimerase AOD69_19430 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AOD69_19435 ENOG4105D9P serine threonine protein kinase AOD69_19440 ENOG4108ZF3 Phosphatase AOD69_19450 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AOD69_19460 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AOD69_19465 ENOG4105C25 Primosomal protein n' AOD69_19470 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AOD69_19490 ENOG4105DSJ YicC domain protein AOD69_19500 ENOG4105F23 Fibronectin-binding protein AOD69_19505 ENOG4105DC7 peptidase M24 AOD69_19560 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AOD69_19585 ENOG4105C34 Pseudouridine synthase AOD69_19600 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AOD69_19610 ENOG4105DBK s4 domain protein AOD69_19615 ENOG41067XK integral membrane protein AOD69_19625 ENOG4105DFA alanine racemase domain protein AOD69_19630 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AOD69_19635 ENOG4105WR5 sporulation protein, YlmC YmxH family AOD69_19645 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD69_19655 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AOD69_19660 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AOD69_19665 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AOD69_19670 ENOG4105D4A Cell wall formation (By similarity) AOD69_19675 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AOD69_19680 ENOG4105CNI cell division protein FtsW AOD69_19695 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOD69_19700 ENOG4105CJN penicillin-binding protein AOD69_19705 ENOG4105CJN penicillin-binding protein AOD69_19710 ENOG41068DC Essential cell division protein (By similarity) AOD69_19745 ENOG4105KNH Nucleic acid-binding protein AOD69_19795 ENOG4105XSJ toxin secretion phage lysis holin AOD69_19880 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AOD69_19890 ENOG4105CAR Terminase, large subunit AOD69_19980 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AOD69_19990 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD69_20045 ENOG4108IMY Transcriptional regulator AOD69_20070 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) AOD69_20080 ENOG41063PX domain protein AOD69_20085 ENOG4105D78 K07001 NTE family protein AOD69_20090 ENOG4105H20 Sporulation integral membrane protein YlbJ AOD69_20100 ENOG4106H78 methyltransferase AOD69_20120 ENOG4107TB6 phosphoglycerate mutase AOD69_20135 ENOG4106UY4 Inherit from COG: Scp-like extracellular AOD69_20185 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AOD69_20190 ENOG4105CNI cell division protein FtsW AOD69_20205 ENOG4108IAB Phoh family AOD69_20225 ENOG4105QA2 AOD69_20230 ENOG4105CI3 gtp-binding protein typa AOD69_20240 ENOG4105ECY inositol monophosphatase AOD69_20260 ENOG4105CXN decarboxylase AOD69_20305 ENOG4105C7S Dehydrogenase AOD69_20310 ENOG4105CPP Dehydrogenase, E1 component AOD69_20325 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AOD69_20330 ENOG4108X4Q Hydrolase AOD69_20340 ENOG4105CN5 Metallo-Beta-Lactamase AOD69_20345 ENOG4107ZYR domain protein AOD69_20380 ENOG4108XRC Protein of unknown function (DUF458) AOD69_20390 ENOG4107IN1 Protein of unknown function (DUF1797) AOD69_20405 ENOG4105EPM Diguanylate phosphodiesterase AOD69_20410 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AOD69_20425 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AOD69_20435 ENOG4105UIN AOD69_20500 ENOG4108HGU Histidine kinase AOD69_20510 ENOG4105CHM Aminotransferase AOD69_20515 ENOG4105FKQ transcriptional regulator AOD69_20520 ENOG4105EG2 ABC transporter, permease AOD69_20530 ENOG4107FKK extracellular solute-binding protein family 1 AOD69_20540 ENOG4105CG3 alpha amylase, catalytic region AOD69_20585 ENOG4105CHU acetyl-coa acetyltransferase AOD69_20625 ENOG4105K7K Transcriptional regulator AOD69_20630 ENOG4105DTD Dehydrogenase AOD69_20640 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AOD69_20650 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AOD69_20675 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AOD69_20695 ENOG4106TD9 Diguanylate cyclase AOD69_20715 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AOD69_20730 ENOG4105CID antiterminator AOD69_20740 ENOG4105FDP GntR family transcriptional regulator AOD69_20750 ENOG4105CE4 GlcNAc 6-P deacetylase AOD69_20795 ENOG4107ZE5 PPIases accelerate the folding of proteins AOD69_20800 ENOG4105PTM secreted protein AOD69_20805 ENOG4105J7I hydrolase AOD69_20815 ENOG4105G6R Stage v sporulation protein ae AOD69_20825 ENOG4105CZ3 stage V sporulation protein ad AOD69_20830 ENOG41090VF Stage v sporulation protein ac AOD69_20850 ENOG4105C8J )-transporter AOD69_20855 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD69_20865 ENOG41082AN stage II sporulation protein AOD69_20870 ENOG4105DZ1 carboxypeptidase AOD69_20875 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOD69_20880 ENOG4105DVE abc transporter atp-binding protein AOD69_20915 ENOG4105D7N magnesium and cobalt transport protein CorA AOD69_20940 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AOD69_20950 ENOG4105I3K Ferric uptake regulator, Fur family AOD69_20955 ENOG4105MZ9 stage II sporulation protein m AOD69_20975 ENOG4105CPC Aldo Keto reductase AOD69_20985 ENOG4105RHY Pfam:UPF0157 AOD69_21005 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AOD69_21015 ENOG4105ETE Transcriptional regulator (LacI family AOD69_21020 ENOG4108YM7 Gcn5-related n-acetyltransferase AOD69_21040 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AOD69_21045 ENOG4108R6K riboflavin synthase, subunit alpha AOD69_21065 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AOD69_21070 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOD69_21075 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOD69_21080 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AOD69_21090 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOD69_21100 ENOG4105DFD Na H antiporter AOD69_21105 ENOG4105CGH 5'-nucleotidase AOD69_21145 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AOD69_21160 ENOG4108IXY short-chain dehydrogenase reductase AOD69_21165 ENOG41069FQ Metallo-beta-lactamase superfamily AOD69_21175 ENOG4105II7 pyrroline-5-carboxylate reductase AOD69_21180 ENOG4105EJQ L-serine dehydratase AOD69_21205 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AOD69_21215 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AOD69_21220 ENOG4105D9U N-acetyltransferase AOD69_21235 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AOD69_21240 ENOG4108QEG Membrane AOD69_21245 ENOG4105CDA abc transporter atp-binding protein AOD69_21250 ENOG4105E5Q amino acid AbC transporter AOD69_21255 ENOG4108HW3 (ABC) transporter AOD69_21265 ENOG4105G7B Protein of unknown function (DUF2992) AOD69_21285 ENOG4105C7S Dehydrogenase AOD69_21290 ENOG4105CPP Dehydrogenase, E1 component AOD69_21310 ENOG4107RDP Dehydrogenase AOD69_21325 ENOG4108JUB Transcriptional regulator AOD69_21335 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AOD69_21350 ENOG4107QQR Sporulation AOD69_21360 ENOG4105S1Z Stage IV sporulation protein B AOD69_21365 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AOD69_21375 ENOG4105DX0 Hemolysin A AOD69_21385 ENOG4105CTB Polyprenyl synthetase AOD69_21410 ENOG4108ZSR alkaline shock protein AOD69_21415 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AOD69_21440 ENOG410644B Stage III sporulation protein af AOD69_21450 ENOG4105KQ4 Stage iii sporulation protein ad AOD69_21455 ENOG4108CQH stage III sporulation protein AC AOD69_21460 ENOG4105KR5 Stage iii sporulation protein AOD69_21465 ENOG4105CD2 stage iii sporulation protein aa AOD69_21490 ENOG4105DC7 peptidase M24 AOD69_21505 ENOG4105CBJ Metal-dependent enzyme AOD69_21515 ENOG4107YBY Hydrolase AOD69_21535 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AOD69_21540 ENOG4105WZW rhodanese family AOD69_21580 ENOG4105CJ1 ABC, transporter AOD69_21585 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOD69_21615 ENOG4105C0D helicase AOD69_21735 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AOD69_21740 ENOG4105C3R Methionine synthase AOD69_21755 ENOG4105C28 cystathionine AOD69_21760 ENOG4105C28 cystathionine AOD69_21785 ENOG4105C5X domain protein AOD69_21795 ENOG4105DKQ ROK family AOD69_21805 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AOD69_21820 ENOG4108UTW Plays a role in the regulation of phosphate uptake AOD69_21825 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AOD69_21830 ENOG4105E2Z phosphate ABC transporter (Permease AOD69_21835 ENOG4105C8U phosphate abc transporter AOD69_21840 ENOG4105PWN phosphate abc transporter AOD69_21845 ENOG4107RF6 penicillin-binding protein AOD69_21855 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOD69_21880 ENOG4105N80 Ferric uptake regulator, Fur family AOD69_21890 ENOG4105FDK ABC transporter AOD69_21895 ENOG4108JYZ YitT family AOD69_21900 ENOG41069ZM Protein of unknown function (DUF2624) AOD69_21925 ENOG4105EGD dinuclear metal center protein, YbgI family AOD69_21940 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD69_21945 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AOD69_21980 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AOD69_21985 ENOG4105KG3 cytidine deaminase AOD69_21990 ENOG4107YR5 Diacylglycerol kinase AOD69_22000 ENOG4105CTJ Metal Dependent Phosphohydrolase AOD69_22005 ENOG4105C9A Phoh family AOD69_22020 ENOG41068P3 sporulation protein YqfC AOD69_22025 ENOG4105KTH gatB Yqey AOD69_22035 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AOD69_22040 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AOD69_22060 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AOD69_22070 ENOG4105CSA Coproporphyrinogen iii oxidase AOD69_22075 ENOG4105KVH Transcriptional regulator AOD69_22100 ENOG4105TQK DNA polymerase iii, delta' subunit AOD69_22110 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AOD69_22115 ENOG4108UK2 deaminase AOD69_22120 ENOG4105KQC Competence protein AOD69_22130 ENOG4105DXX methyltransferase AOD69_22140 ENOG4108WF2 Metal Dependent Phosphohydrolase AOD69_22150 ENOG410812S Rna-binding protein AOD69_22160 ENOG4105CQW ribosome biogenesis GTPase YqeH AOD69_22165 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AOD69_22180 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD69_22200 ENOG4108TVJ Nitroreductase AOD69_22215 ENOG4105G6Z alkaline phosphatase AOD69_22225 ENOG4108MUZ hydrolase AOD69_22260 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AOD69_22265 ENOG4105MIR Phenylalanine 4-monooxygenase AOD69_22275 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOD69_22280 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOD69_22320 ENOG4105S6R Iron-hydroxamate transporter permease subunit AOD69_22325 ENOG4108V5C ABC transporter AOD69_22335 ENOG4108EKI Dehydrogenase AOD69_22340 ENOG4105C28 cystathionine AOD69_22370 ENOG4107XRG penicillin-binding protein AOD69_22385 ENOG4105CFP Peptidase U32 AOD69_22390 ENOG4105XYU peptidase (U32 family) AOD69_22395 ENOG4108VQJ O-methyltransferase AOD69_22400 ENOG4105HHA aminodeoxychorismate lyase AOD69_22420 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOD69_22430 ENOG4105C02 permease AOD69_22445 ENOG41060CR AOD69_22450 ENOG4105C7H Helicase, RecD TraA family AOD69_22460 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AOD69_22465 ENOG4105C3J Cysteine desulfurase AOD69_22475 ENOG4105D1H recombination factor protein RarA AOD69_22480 ENOG4108VCI transcription factor, rsfa family AOD69_22485 ENOG4105CUZ uba thif-type nad fad binding protein AOD69_22495 ENOG4105CUT histidyl-tRNA synthetase AOD69_22510 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AOD69_22520 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AOD69_22525 ENOG41076HS cation diffusion facilitator family transporter AOD69_22530 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AOD69_22540 ENOG4105CKP Polysaccharide Biosynthesis Protein AOD69_22545 ENOG4108QG2 Membrane AOD69_22555 ENOG4105VIE preprotein translocase, subunit YajC AOD69_22570 ENOG41061AI Protein of unknown function (DUF2905) AOD69_22585 ENOG4108HUF Transporter AOD69_22595 ENOG4108IPJ Membrane AOD69_22600 ENOG4108IPJ Membrane AOD69_22605 ENOG41082BM Transcriptional regulator, arsr family AOD69_22630 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AOD69_22635 ENOG4108IYU L-aspartate oxidase AOD69_22650 ENOG4108RPX mosc domain containing protein AOD69_22655 ENOG4105CQC Prephenate dehydratase AOD69_22675 ENOG4105EWM Histidine kinase AOD69_22690 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AOD69_22705 ENOG4105X36 (ribosomal) protein AOD69_22715 ENOG4105C03 ribonuclease AOD69_22730 ENOG4107QMS site-determining protein AOD69_22745 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AOD69_22750 ENOG4105DFF Rod shape-determining protein mreb AOD69_22770 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AOD69_22775 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AOD69_22785 ENOG41068KH stage VI sporulation protein D AOD69_22795 ENOG4105D52 delta-aminolevulinic acid dehydratase AOD69_22820 ENOG4105K56 Transcriptional regulator AOD69_22840 ENOG4108IUQ atp-dependent protease AOD69_22870 ENOG4108QCI YvbH-like oligomerisation region AOD69_22890 ENOG4105M59 Phosphodiesterase, mj0936 family AOD69_22895 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AOD69_22905 ENOG4108XJQ germination protein AOD69_22915 ENOG4108PCX Major Facilitator AOD69_22925 ENOG4105KBX Transcriptional regulator, TetR family AOD69_22940 ENOG4105PFC Transcriptional regulator AOD69_22955 ENOG4105DZC cytosine deaminase AOD69_22960 ENOG4105DZC cytosine deaminase AOD69_22965 ENOG4105DEF Extracellular solute-binding protein, family 5 AOD69_22970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD69_22985 ENOG4108JQ7 (ABC) transporter AOD69_22990 ENOG4108HRK Histidine kinase AOD69_22995 ENOG4105DY9 regulatoR AOD69_23010 ENOG41067S9 phage shock protein C, PspC AOD69_23015 ENOG4108JCI Transcriptional regulator AOD69_23025 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AOD69_23030 ENOG4108Z40 Transcriptional regulator AOD69_23035 ENOG4105RHA ABC transporter, permease AOD69_23040 ENOG4108IUX (ABC) transporter AOD69_23045 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AOD69_23055 ENOG4105E14 MotA TolQ exbB proton channel AOD69_23060 ENOG4108VXD carboxy-peptidase AOD69_23070 ENOG4105E33 succinate dehydrogenase AOD69_23080 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AOD69_23095 ENOG4105K63 Thioredoxin AOD69_23100 ENOG4105C10 Electron transfer flavoprotein AOD69_23105 ENOG4105BZJ Electron transfer flavoprotein AOD69_23110 ENOG41060WC Enoyl-CoA hydratase AOD69_23115 ENOG4107Z3H Transcriptional regulator, TetR family AOD69_23120 ENOG4105CEY Amp-dependent synthetase and ligase AOD69_23130 ENOG4105J76 Periplasmic binding protein AOD69_23135 ENOG4105S6R Iron-hydroxamate transporter permease subunit AOD69_23180 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD69_23195 ENOG4105DR4 Methyltransferase AOD69_23210 ENOG4105KFN sortase, SrtB family AOD69_23215 ENOG4105E0A ABC, transporter AOD69_23230 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AOD69_23240 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AOD69_23250 ENOG4105FE9 pseudouridine synthase AOD69_23265 ENOG4105DCG PHP domain protein AOD69_23300 ENOG4105C5S asparaginyl-tRNA synthetase AOD69_23305 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AOD69_23315 ENOG4108RWN rrna methyltransferase AOD69_23350 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD69_23355 ENOG4105CW7 secretion protein, HlyD family AOD69_23360 ENOG4108JGH Tetr family transcriptional regulator AOD69_23365 ENOG4105CN9 Peptidase m42 family protein AOD69_23385 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AOD69_23390 ENOG4105C22 threonyL-tRNA synthetase AOD69_23395 ENOG4108TDW sporulation protein YtxC AOD69_23415 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AOD69_23420 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AOD69_23425 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AOD69_23435 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AOD69_23440 ENOG4105C2M dna polymerase I AOD69_23445 ENOG4105BZU Histidine kinase AOD69_23450 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD69_23470 ENOG4108HMX isocitrate dehydrogenase (NADP) AOD69_23475 ENOG4105BZN citrate synthase AOD69_23490 ENOG4108REF Sporulation integral membrane protein ytvi AOD69_23495 ENOG4105FS0 cytoplasmic membrane protein AOD69_23520 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AOD69_23525 ENOG4105C6K Malic enzyme AOD69_23530 ENOG4105C0B DNA polymerase III (alpha subunit) AOD69_23535 ENOG4105VV2 AOD69_23545 ENOG4105SFS phosphoesterase RecJ domain protein AOD69_23580 ENOG4105DC7 peptidase M24 AOD69_23615 ENOG4105Z7P Acetyltransferase (GNAT) family AOD69_23620 ENOG41082W1 Cupin 2, conserved barrel domain protein AOD69_23630 ENOG4105VZ8 Transcriptional regulator AOD69_23650 ENOG4107YZX Universal stress protein AOD69_23690 ENOG4108JYZ YitT family AOD69_23710 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AOD69_23720 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AOD69_23725 ENOG4105KBJ sporulation protein ytfj AOD69_23740 ENOG4105EFZ amidohydrolase AOD69_23750 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AOD69_23775 ENOG4106KR7 LysR family Transcriptional regulator AOD69_23795 ENOG4105C28 cystathionine AOD69_23815 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AOD69_23825 ENOG4105EMN RNA polymerase sigma factor AOD69_23840 ENOG4105F1V Acetoin utilization protein AOD69_23845 ENOG4105W87 Cbs domain AOD69_23850 ENOG4105DGU Histone deacetylase AOD69_23860 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD69_23870 ENOG4107SNB ankyrin repeat protein YahD AOD69_23875 ENOG4105EP9 oxidoreductase AOD69_23905 ENOG4105ETE Transcriptional regulator (LacI family AOD69_23930 ENOG4105C88 aminopeptidase AOD69_23975 ENOG4108VDD TRNA binding domain protein AOD69_24005 ENOG4105C8F Beta-lactamase domain protein AOD69_24020 ENOG4108V15 phosphotransferase enzyme family AOD69_24025 ENOG4108IUM Glycogen debranching enzyme AOD69_24040 ENOG4107QSE Dipeptidase AOD69_24045 ENOG4107QSE Dipeptidase AOD69_24050 ENOG4105YW5 deoR family transcriptional regulator AOD69_24065 ENOG4105CBX hi0933 family AOD69_24100 ENOG4108VJ1 Transcriptional regulator (CarD family AOD69_24105 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AOD69_24110 ENOG4105CSC Glucose uptake protein AOD69_24125 ENOG4108ZAF Molybdopterin AOD69_24130 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AOD69_24135 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOD69_24145 ENOG4105D06 uba thif-type nad fad binding protein AOD69_24170 ENOG41085GJ domain protein AOD69_24180 ENOG4105DWV Homoserine O-trans-acetylase AOD69_24190 ENOG4108B31 Spore germination protein AOD69_24225 ENOG410605W Major Facilitator AOD69_24230 ENOG4107S91 Sodium hydrogen exchanger AOD69_24235 ENOG4105NCW Trka-c domain protein AOD69_24250 ENOG4105C19 ABC transporter AOD69_24270 ENOG4105N5T Radical SAM Protein AOD69_24280 ENOG4105DA5 (ABC) transporter AOD69_24310 ENOG4105E8V Alpha Beta Hydrolase Fold protein AOD69_24315 ENOG4108Z0R Transferase AOD69_24320 ENOG4105YVM Phosphoesterase, PA-phosphatase related AOD69_24325 ENOG4105BZF Glycosyl transferase (Group 1 AOD69_24335 ENOG4108RIR Molybdenum cofactor biosynthesis protein AOD69_24390 ENOG4105EGD dinuclear metal center protein, YbgI family AOD69_24395 ENOG4105BZU Histidine kinase AOD69_24400 ENOG4105BZU Histidine kinase AOD69_24405 ENOG4107S9D Alpha beta hydrolase AOD69_24425 ENOG4105D2X ABC transporter substrate-binding protein AOD69_24435 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AOD69_24490 ENOG4108V2W Carbonate dehydratase AOD69_24495 ENOG4105C4M (Ubiquinol oxidase) subunit I AOD69_24500 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AOD69_24545 ENOG41087YS Phage shock protein A AOD69_24580 ENOG4105BZU Histidine kinase AOD69_24585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD69_24610 ENOG4108UGV hypoxanthine phosphoribosyltransferase AOD69_24615 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AOD69_24650 ENOG4107ZTW SNARE associated Golgi AOD69_24665 ENOG4105C19 ABC transporter AOD69_24670 ENOG41086D8 Transcriptional regulator AOD69_24720 ENOG4105C6Z Gluconate AOD69_24725 ENOG4105FDP GntR family transcriptional regulator AOD69_24745 ENOG41069H0 dihydroorotase EC 3.5.2.3 AOD69_24775 ENOG4105DTQ mandelate racemase muconate lactonizing AOD69_24785 ENOG4108IPT Naphthoate synthase AOD69_24790 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AOD69_24795 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AOD69_24800 ENOG4105E4F Isochorismate synthase AOD69_24805 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AOD69_24815 ENOG4105VEQ Cold shock protein AOD69_24840 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AOD69_24850 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AOD69_24860 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOD69_24955 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AOD69_24990 ENOG4105KT7 mgtC SapB transporter AOD69_24995 ENOG4107PBV potassium channel AOD69_25005 ENOG4107QYV phosphohexose isomerase AOD69_25015 ENOG4105WG9 Conserved Protein AOD69_25025 ENOG4105CHM Aminotransferase AOD69_25030 ENOG4108ZB6 transcriptional regulator AsnC family AOD69_25035 ENOG4105C5I Dehydrogenase AOD69_25040 ENOG4108MUZ hydrolase AOD69_25050 ENOG4105C87 Aminotransferase class I and II AOD69_25065 ENOG4105Y38 Kinase-associated protein B AOD69_25075 ENOG4107R3E Citrate transporter AOD69_25090 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AOD69_25095 ENOG4105KA0 thioesterase Superfamily protein AOD69_25115 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AOD69_25135 ENOG41069ER domain protein AOD69_25150 ENOG4105CEP NADH dehydrogenase AOD69_25180 ENOG4105EWC Purine nucleoside phosphorylase AOD69_25200 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AOD69_25225 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOD69_25230 ENOG4105C4B ABC transporter, permease AOD69_25235 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AOD69_25280 ENOG41083MR nifu domain-containing protein AOD69_25295 ENOG4108W5N phosphatidylglycerophosphatase a AOD69_25310 ENOG4105DYS nad(p)h dehydrogenase (quinone) AOD69_25315 ENOG4105D4U had-superfamily hydrolase, subfamily iia AOD69_25330 ENOG4105CBT Fructose-1,6-bisphosphatase AOD69_25350 ENOG4105MMD transcriptional regulator AOD69_25355 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AOD69_25360 ENOG4107TXC Transcriptional regulator AOD69_25365 ENOG41090T1 Membrane AOD69_25390 ENOG4105FAA peptidase M23 AOD69_25400 ENOG4105KZD Domain of unknown function (DUF1805) AOD69_25405 ENOG4107R8B 5'-nucleotidase AOD69_25430 ENOG4105DIW FeS assembly protein SUFB AOD69_25435 ENOG4108UNV SUF system FeS assembly protein, NifU family AOD69_25440 ENOG4105C9B Cysteine desulfurase AOD69_25445 ENOG4105JRK feS assembly protein SufD AOD69_25450 ENOG4105C3K feS assembly ATPase SufC AOD69_25455 ENOG4105D01 (LipO)protein AOD69_25460 ENOG4105D01 (LipO)protein AOD69_25465 ENOG4108UMI ABC transporter, permease AOD69_25500 ENOG41080E8 Transcriptional regulator, Spx MgsR family AOD69_25550 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOD69_25575 ENOG4108W8B Beta-lactamase domain protein AOD69_25580 ENOG4105C1G acyl-Coa dehydrogenase AOD69_25590 ENOG4105CHU acetyl-coa acetyltransferase AOD69_25605 ENOG4105DZ1 carboxypeptidase AOD69_25625 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AOD69_25645 ENOG4108SUT Major Facilitator Superfamily AOD69_25650 ENOG4107R7I amino acid AOD69_25660 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AOD69_25670 ENOG4107AYK membrAne AOD69_25705 ENOG4107ZTW SNARE associated Golgi AOD69_25715 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AOD69_25720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD69_25725 ENOG4105BZU Histidine kinase AOD69_25735 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AOD69_25750 ENOG4105VG1 fes assembly suf system protein AOD69_25755 ENOG4105D4Y metalloprotease AOD69_25775 ENOG4107S91 Sodium hydrogen exchanger AOD69_25780 ENOG4105NCW Trka-c domain protein AOD69_25795 ENOG4108RMU ferritin dps family protein AOD69_25810 ENOG4108URH decarboxylase AOD69_25835 ENOG4105D9N nucleoside AOD69_25840 ENOG4105D9N nucleoside AOD69_25855 ENOG4108RYK Nad-dependent epimerase dehydratase AOD69_25870 ENOG4105CV8 reductase AOD69_25875 ENOG4105F27 Major Facilitator AOD69_25880 ENOG4105KVH Transcriptional regulator AOD69_25895 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AOD69_25900 ENOG4105D4A Cell wall formation (By similarity) AOD69_25910 ENOG4105C8Q Methyl-accepting chemotaxis AOD69_25920 ENOG4105WMR Protein CrcB homolog AOD69_25925 ENOG4105WMR Protein CrcB homolog AOD69_25940 ENOG4108MK9 spermidine N(1)-acetyltransferase AOD69_25945 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AOD69_25960 ENOG4108IPW abc transporter atp-binding protein AOD69_25965 ENOG4105CM4 permease protein AOD69_25990 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AOD69_26000 ENOG4105XZU Preprotein translocase, subunit SecG AOD69_26005 ENOG41067MG lrgb family AOD69_26105 ENOG4105EFC phage portal protein HK97 family AOD69_26130 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AOD69_26140 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AOD69_26145 ENOG4105CP7 Triose-phosphate isomerase AOD69_26170 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD69_26190 ENOG41090VF Stage v sporulation protein ac AOD69_26195 ENOG4105CZ3 stage V sporulation protein ad AOD69_26210 ENOG4105H67 Protein of unknown function (DUF421) AOD69_26215 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AOD69_26220 ENOG4105KRI phosphocarrier protein (HPr AOD69_26230 ENOG4105CHW UPF0052 protein AOD69_26240 ENOG4108Z4K mutator MutT protein AOD69_26250 ENOG4105C3M thioredoxin reductase AOD69_26260 ENOG4108S4C acetyltransferase AOD69_26280 ENOG41086DT Membrane protein of unknown function AOD69_26290 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOD69_26295 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AOD69_26300 ENOG4105D7V transposase AOD69_26315 ENOG4107TXC Transcriptional regulator AOD69_26340 ENOG4105HMI Membrane AOD69_26345 ENOG4105DUM transcriptional regulator, lysR family AOD69_26355 ENOG4108WS4 fmn reductase AOD69_26370 ENOG4105BZ1 (ABC) transporter AOD69_26380 ENOG4105CN1 protease AOD69_26385 ENOG4105CRP Part of the ABC transporter FtsEX involved in AOD69_26390 ENOG4105CAK Cell division ATP-binding protein ftsE AOD69_26405 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AOD69_26410 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AOD69_26415 ENOG4105MS2 ribosomal subunit Interface protein AOD69_26420 ENOG4105VEQ Cold shock protein AOD69_26425 ENOG41081UC Inherit from COG: Competence protein AOD69_26440 ENOG4105KVH Transcriptional regulator AOD69_26455 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AOD69_26460 ENOG4108KGH TRANSCRIPTIONal AOD69_26465 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AOD69_26470 ENOG4105C6Y Udp-glucose 6-dehydrogenase AOD69_26475 ENOG4105ESV Glycosyl transferase, family 4 AOD69_26485 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOD69_26500 ENOG410901P UPF0249 protein AOD69_26505 ENOG4105F8D glycoside hydrolase family 4 AOD69_26510 ENOG4105VCP PTS System AOD69_26515 ENOG4105CK1 PTS System AOD69_26525 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AOD69_26530 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AOD69_26535 ENOG4105VCP PTS System AOD69_26545 ENOG4105VZJ PTS System AOD69_26560 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AOD69_26565 ENOG4105ECB domain protein AOD69_26570 ENOG4107RSM transcriptional regulator AOD69_26615 ENOG4105DAA L-lactate AOD69_26625 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AOD69_26635 ENOG4105E0M Sulfatase AOD69_26670 ENOG4105C94 Transporter AOD69_26675 ENOG41069ER domain protein AOD69_26700 ENOG4105KBK Zinc finger, swim domain protein AOD69_26705 ENOG4105C0D helicase AOD69_26735 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD69_26745 ENOG4107RBB ABC transporter, permease AOD69_26750 ENOG4105C19 ABC transporter AOD69_26770 ENOG4105CXY transporter AOD69_26785 ENOG4105BZU Histidine kinase AOD69_26790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD69_26795 ENOG4105CMR udp-glucose 4-epimerase AOD69_26810 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AOD69_26815 ENOG4105EY8 ABC transporter AOD69_26870 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AOD69_26885 ENOG4105FRN stage II sporulation protein AOD69_26900 ENOG4105DY9 regulatoR AOD69_26905 ENOG4108IUW ABC transporter AOD69_26925 ENOG4106778 Protein of unknown function (DUF1146) AOD69_26930 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AOD69_26935 ENOG4105C8S subunit m AOD69_26940 ENOG4105D65 subunit l AOD69_26965 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AOD69_26970 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AOD69_26980 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AOD69_26985 ENOG4105BZU Histidine kinase AOD69_27035 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AOD69_27040 ENOG41062M3 atp synthase AOD69_27070 ENOG4108YZG isomerase AOD69_27085 ENOG4108VGI doxx family AOD69_27090 ENOG4107XC4 flavin reductase domain protein, FMN-binding AOD69_27105 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AOD69_27115 ENOG4108ZXQ stage ii sporulation protein r AOD69_27120 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AOD69_27125 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AOD69_27140 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AOD69_27145 ENOG4105CBT Fructose-1,6-bisphosphatase AOD69_27150 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AOD69_27185 ENOG4105C1G acyl-Coa dehydrogenase AOD69_27190 ENOG4105C1G acyl-Coa dehydrogenase AOD69_27195 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AOD69_27205 ENOG4105DF6 Fe-S oxidoreductase AOD69_27220 ENOG4105BZU Histidine kinase AOD69_27240 ENOG4105BZU Histidine kinase AOD69_27245 ENOG4105KCT ABC transporter AOD69_27250 ENOG4108M15 ABC transporter AOD69_27255 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AOD69_27275 ENOG4105IIU Aminopeptidase AOD69_27295 ENOG4105EMN RNA polymerase sigma factor AOD69_27305 ENOG410684U Domain of unknown function (DUF1934) AOD69_27330 ENOG4105CYW agmatinase AOD69_27340 ENOG4105DXB Major Facilitator superfamily AOD69_27345 ENOG4107SWG transcriptional regulator MERR family AOD69_27350 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AOD69_27355 ENOG4105BZ4 penicillin-binding protein AOD69_27360 ENOG4108XFG YwhD family AOD69_27365 ENOG4108Z4T Peptidase M50 AOD69_27370 ENOG41069HH 4-oxalocrotonate tautomerase AOD69_27375 ENOG4105DCI Phosphohydrolase AOD69_27380 ENOG4108MES Periplasmic binding protein AOD69_27385 ENOG4105E0A ABC, transporter AOD69_27390 ENOG4105EHG Permease protein AOD69_27395 ENOG4105DQ5 transport system permease protein AOD69_27400 ENOG4105DQ5 transport system permease protein AOD69_27410 ENOG4108VCI transcription factor, rsfa family AOD69_27425 ENOG4108IJ2 phosphate acetyltransferase AOD69_27440 ENOG4108VKI Cell wall hydrolase AOD69_27470 ENOG410667J hydrolase AOD69_27475 ENOG4105VCH membrane AOD69_27485 ENOG4108TU7 Inherit from COG: (ABC) transporter AOD69_27490 ENOG4105CJ1 ABC, transporter AOD69_27495 ENOG41090WU lipolytic protein G-D-S-L family AOD69_27510 ENOG4105D6E homoserine dehydrogenase AOD69_27535 ENOG4108Y4K DNA-binding transcriptional activator AOD69_27545 ENOG4105WH1 Two component transcriptional regulator luxr family AOD69_27555 ENOG4105DWF phosphomethylpyrimidine kinase AOD69_27560 ENOG4105BZU Histidine kinase AOD69_27565 ENOG4105VCD cytoplasmic protein AOD69_27570 ENOG4105D22 carbon starvation protein AOD69_27575 ENOG4105DY9 regulatoR AOD69_27580 ENOG41079KZ Major Facilitator Superfamily AOD69_27600 ENOG4105EN6 Membrane AOD69_27605 ENOG4106YBV Methyl-accepting chemotaxis AOD69_27615 ENOG4108S4H thioesterase Superfamily protein AOD69_27625 ENOG4105JEU Glycosyl transferase, family 2 AOD69_27630 ENOG4105C5H ABC transporter AOD69_27660 ENOG4105CKK Glycosyl transferase, family 2 AOD69_27665 ENOG41067SE Tetr family transcriptional regulator AOD69_27675 ENOG4105E0X reductase AOD69_27680 ENOG4106F5Q Membrane AOD69_27695 ENOG4105DY9 regulatoR AOD69_27700 ENOG4108HRK Histidine kinase AOD69_27705 ENOG4107RGD Major Facilitator superfamily AOD69_27720 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOD69_27730 ENOG4105IW1 AmiS UreI transporter AOD69_27740 ENOG4105CMR udp-glucose 4-epimerase AOD69_27745 ENOG4108UT2 hemolysin iii AOD69_27755 ENOG4105C1J atp-dependent rna helicase AOD69_27770 ENOG4105DPN Oligoendopeptidase f AOD69_27790 ENOG4105C0H protease AOD69_27795 ENOG4105Q2H domain protein AOD69_27810 ENOG4105BZU Histidine kinase AOD69_27815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD69_27845 ENOG4105CDU Replicative dna helicase AOD69_27855 ENOG4105BZR domain protein AOD69_27860 ENOG4108XMW Membrane AOD69_27870 ENOG4108UUM single-stranded DNA-binding protein AOD69_27880 ENOG4105C3G gtp-binding protein AOD69_27885 ENOG4105VDK protein, conserved in bacteria AOD69_27890 ENOG4105D8X mechanosensitive ion channel AOD69_27895 ENOG4108ZDA Sporulation protein YyaC AOD69_27900 ENOG4105FA0 parb-like partition protein AOD69_27905 ENOG4107QJE Chromosome Partitioning Protein AOD69_27925 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AOD69_27935 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins