locus-tag class description AOQ80_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AOQ80_00015 ENOG410848D S4 domain protein YaaA AOQ80_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOQ80_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AOQ80_00100 ENOG4105ZMH deoxynucleoside kinase AOQ80_00110 ENOG4105GTG Isochorismatase AOQ80_00120 ENOG4108Z6B deaminase AOQ80_00125 ENOG4105C6E dna polymerase iii AOQ80_00145 ENOG41067KS pro-sigma K processing AOQ80_00180 ENOG4105CXN decarboxylase AOQ80_00190 ENOG4105FA2 dna polymerase iii AOQ80_00195 ENOG4105MA4 psp1 domain protein AOQ80_00205 ENOG41060K3 Methyltransferase AOQ80_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AOQ80_00220 ENOG4105KRN Transcriptional regulator, abrb family AOQ80_00230 ENOG4105F8V Hydrolase, tatD family AOQ80_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AOQ80_00245 ENOG4105XFA sporulation peptidase YabG AOQ80_00250 ENOG4105W42 Veg protein AOQ80_00265 ENOG4105DFT pur operon repressor AOQ80_00270 ENOG4105KME endoribonuclease L-psp AOQ80_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AOQ80_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AOQ80_00300 ENOG4108JA2 transcriptioN-repair coupling factor AOQ80_00305 ENOG4108M14 stage v sporulation protein t AOQ80_00315 ENOG4108IY2 MazG family AOQ80_00320 ENOG41082I2 s4 domain protein AOQ80_00325 ENOG4105VYY sporulation protein yabp AOQ80_00340 ENOG41060GV RNA binding s1 domain protein AOQ80_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AOQ80_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase AOQ80_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AOQ80_00385 ENOG4105C6T cysteine synthase AOQ80_00390 ENOG4105CRQ synthase (Component I) AOQ80_00395 ENOG4105DDQ anthranilate synthase AOQ80_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AOQ80_00405 ENOG4105EEI dihydropteroate synthase AOQ80_00410 ENOG4105KRF dihydroneopterin aldolase AOQ80_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AOQ80_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AOQ80_00455 ENOG4108Z0C Uvrb UvrC protein AOQ80_00470 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AOQ80_00480 ENOG4105CTP PilT protein domain protein AOQ80_00500 ENOG4105D7W serine acetyltransferase AOQ80_00515 ENOG4105C2N RNA methyltransferase TrmH family group 3 AOQ80_00520 ENOG4105M0M Tetracycline resistance protein AOQ80_00525 ENOG4105QIV RNA polymerase AOQ80_00540 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AOQ80_00565 ENOG4107Y49 methyltransferase AOQ80_00575 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AOQ80_00580 ENOG4105XPM ribosomal protein AOQ80_00685 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AOQ80_00710 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AOQ80_00720 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AOQ80_00730 ENOG41067V7 50S ribosomal protein L36 AOQ80_00760 ENOG4108JJB ABC transporter AOQ80_00765 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AOQ80_00770 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AOQ80_00795 ENOG4105D1F ATP-binding protein AOQ80_00810 ENOG4108NMV polysaccharide deacetylase AOQ80_00895 ENOG4105C8B TIGR00159 family AOQ80_00900 ENOG4107U5W ybbr family AOQ80_00915 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AOQ80_00920 ENOG4108VQT Alpha beta hydrolase fold protein AOQ80_00940 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AOQ80_00945 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AOQ80_00980 ENOG4108PSK reductase AOQ80_00985 ENOG4108UMI ABC transporter, permease AOQ80_00990 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOQ80_00995 ENOG4105D01 (LipO)protein AOQ80_01000 ENOG4105EE1 crotonyl-CoA reductase AOQ80_01010 ENOG4105IQ5 FAD linked oxidase domain protein AOQ80_01025 ENOG4105C2C drug resistance transporter, Bcr CflA AOQ80_01040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOQ80_01045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOQ80_01050 ENOG4105C3U ABC transporter AOQ80_01055 ENOG4108JQ7 (ABC) transporter AOQ80_01085 ENOG4108J59 Extracellular solute-binding protein, family 5 AOQ80_01090 ENOG4108J59 Extracellular solute-binding protein, family 5 AOQ80_01100 ENOG4105II7 pyrroline-5-carboxylate reductase AOQ80_01110 ENOG4107XDY Nicotinamide Mononucleotide Transporter AOQ80_01120 ENOG4105E0C molybdate abc transporter AOQ80_01125 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOQ80_01130 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOQ80_01135 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AOQ80_01150 ENOG4105EGI Transcriptional regulator AOQ80_01165 ENOG4105F6E Acyl-transferase AOQ80_01185 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AOQ80_01200 ENOG4108RE7 deoxyribonuclease AOQ80_01205 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AOQ80_01230 ENOG4105C5H ABC transporter AOQ80_01245 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AOQ80_01255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOQ80_01260 ENOG4105C3U ABC transporter AOQ80_01265 ENOG4108JQ7 (ABC) transporter AOQ80_01290 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AOQ80_01295 ENOG4105ERH Fumarylacetoacetate hydrolase AOQ80_01305 ENOG4108SC4 )-transporter AOQ80_01310 ENOG4105CPF Cell wall formation (By similarity) AOQ80_01315 ENOG4105CPF Cell wall formation (By similarity) AOQ80_01320 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AOQ80_01335 ENOG4107ZXI Rhomboid family AOQ80_01345 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AOQ80_01350 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AOQ80_01360 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AOQ80_01460 ENOG4105K8N protein family UPF0079, ATPase AOQ80_01465 ENOG41072GX Peptidase M22 Glycoprotease AOQ80_01470 ENOG410801F ribosomal-protein-alanine acetyltransferase AOQ80_01475 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AOQ80_01480 ENOG4105C5H ABC transporter AOQ80_01495 ENOG4108TYN CAAX amino terminal protease family protein AOQ80_01515 ENOG4105C7N Xanthine uracil vitamin C permease AOQ80_01525 ENOG4105BZU Histidine kinase AOQ80_01555 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOQ80_01595 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOQ80_01615 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOQ80_01635 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AOQ80_01640 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AOQ80_01645 ENOG4105C83 adenylosuccinate lyase AOQ80_01655 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AOQ80_01680 ENOG4108V3E phosphoribosylglycinamide formyltransferase AOQ80_01690 ENOG4105C12 Phosphoribosylglycinamide synthetase AOQ80_01715 ENOG4105C4R Atp-dependent dna helicase AOQ80_01745 ENOG4108W2Y isochorismatase AOQ80_01750 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOQ80_01755 ENOG4108UMI ABC transporter, permease AOQ80_01760 ENOG4105D01 (LipO)protein AOQ80_01780 ENOG410834F Transcriptional regulator AOQ80_01805 ENOG4105CBD Diacylglycerol kinase AOQ80_01810 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AOQ80_01815 ENOG4108JPW Aminotransferase AOQ80_01825 ENOG4105C26 Dehydrogenase AOQ80_01830 ENOG4105KPY Small multidrug resistance protein AOQ80_01850 ENOG4105D9N nucleoside AOQ80_01855 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AOQ80_01870 ENOG4108W15 Protein of unknown function (DUF1456) AOQ80_01885 ENOG4105DTQ mandelate racemase muconate lactonizing AOQ80_01895 ENOG4105DFD Na H antiporter AOQ80_01915 ENOG4105D3R alkyl hydroperoxide reductase AOQ80_01920 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AOQ80_01930 ENOG4107W7X Aldolase AOQ80_01935 ENOG4105EHG Permease protein AOQ80_01940 ENOG4105DQ5 transport system permease protein AOQ80_01945 ENOG4108V5C ABC transporter AOQ80_01970 ENOG4106UIA AOQ80_01975 ENOG4106UIA AOQ80_02000 ENOG4105BZU Histidine kinase AOQ80_02020 ENOG410756H nucleotidyltransferase AOQ80_02025 ENOG4105D2S major facilitator superfamily AOQ80_02040 ENOG4105E5Q amino acid AbC transporter AOQ80_02045 ENOG4105EAB amino acid AbC transporter AOQ80_02060 ENOG4105C8Q Methyl-accepting chemotaxis AOQ80_02065 ENOG4105C8Q Methyl-accepting chemotaxis AOQ80_02075 ENOG4105CI1 PTS System AOQ80_02105 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AOQ80_02120 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AOQ80_02135 ENOG4105C5H ABC transporter AOQ80_02160 ENOG41062JF Transcriptional regulator AOQ80_02180 ENOG4105DEU major facilitator superfamily AOQ80_02195 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) AOQ80_02210 ENOG4108N0M stress protein AOQ80_02215 ENOG4106FN3 tellurium resistance protein AOQ80_02220 ENOG4106FN3 tellurium resistance protein AOQ80_02225 ENOG4107TS3 membrane protein, TerC AOQ80_02230 ENOG4108TTB tellurium resistance protein AOQ80_02250 ENOG4105KJF protein tyrosine phosphatase AOQ80_02260 ENOG4107U9T Pfam:Ribonuclease_BN AOQ80_02265 ENOG4105C59 p-type ATPase AOQ80_02270 ENOG4108IPJ Membrane AOQ80_02290 ENOG4107ZTW SNARE associated Golgi AOQ80_02305 ENOG410606W general stress protein AOQ80_02310 ENOG4105UPD Calcium Proton AOQ80_02350 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AOQ80_02355 ENOG4105VTR Integrase AOQ80_02360 ENOG4108IMY Transcriptional regulator AOQ80_02635 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AOQ80_02645 ENOG4108JUB Transcriptional regulator AOQ80_02655 ENOG4108IQI permease AOQ80_02690 ENOG4105CSV Glutaminase AOQ80_02700 ENOG4108A04 Beta-lactamase AOQ80_02715 ENOG4105CKK Glycosyl transferase, family 2 AOQ80_02725 ENOG4107QQG Dehydrogenase AOQ80_02730 ENOG4105C3I Nad-dependent epimerase dehydratase AOQ80_02750 ENOG4105F1A Pyruvate formate-lyase AOQ80_02770 ENOG4105CI2 imidazolone-5-propionate hydrolase AOQ80_02775 ENOG4105ECP epimerase AOQ80_02805 ENOG41067AE Membrane-bound metal-dependent hydrolase AOQ80_02810 ENOG4105CEN a g-specific adenine glycosylase AOQ80_02815 ENOG4106BXE AOQ80_02835 ENOG4105BZ1 (ABC) transporter AOQ80_02840 ENOG4107NBY Membrane AOQ80_02845 ENOG4105CBC glutamate synthase AOQ80_02855 ENOG4108IUW ABC transporter AOQ80_02875 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AOQ80_02880 ENOG4105G5W regulator Fur family AOQ80_02995 ENOG4108JQC penicillin-binding protein 1A AOQ80_03000 ENOG4107ZQN disulfide bond AOQ80_03010 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AOQ80_03020 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AOQ80_03025 ENOG4105BZU Histidine kinase AOQ80_03035 ENOG4105CYN Serine protein kinase AOQ80_03060 ENOG4105C94 Transporter AOQ80_03075 ENOG4105DZ6 Band 7 protein AOQ80_03085 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AOQ80_03095 ENOG4105D4T Citrate transporter AOQ80_03115 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AOQ80_03120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOQ80_03125 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AOQ80_03130 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AOQ80_03135 ENOG4105BZ7 extracellular solute-binding protein family 1 AOQ80_03140 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AOQ80_03145 ENOG4108STX response regulator AOQ80_03150 ENOG4105US7 Histidine kinase AOQ80_03175 ENOG4108MRH transcriptional regulatory protein AOQ80_03185 ENOG4105C6K Malic enzyme AOQ80_03195 ENOG4108UZ3 Transporter AOQ80_03200 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AOQ80_03210 ENOG4105BZU Histidine kinase AOQ80_03215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOQ80_03225 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AOQ80_03230 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AOQ80_03235 ENOG4108JB9 formate dehydrogenase AOQ80_03255 ENOG4105CUB amino acid AOQ80_03265 ENOG4105C59 p-type ATPase AOQ80_03270 ENOG4105DAP Nicotinate phosphoribosyltransferase AOQ80_03300 ENOG41073R8 VanW family AOQ80_03305 ENOG4108KGH TRANSCRIPTIONal AOQ80_03310 ENOG4105D9N nucleoside AOQ80_03315 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AOQ80_03320 ENOG4105C37 (CBS) domain AOQ80_03325 ENOG4108IJ0 Aspartate ammonia-lyase AOQ80_03330 ENOG4105DAA L-lactate AOQ80_03345 ENOG4105DUX Transporter AOQ80_03350 ENOG4108MES Periplasmic binding protein AOQ80_03355 ENOG4105DQ5 transport system permease protein AOQ80_03360 ENOG4108IHU transport system permease protein AOQ80_03365 ENOG4105E0A ABC, transporter AOQ80_03370 ENOG4105DMQ Methyltransferase AOQ80_03390 ENOG4107T89 von Willebrand factor, type A AOQ80_03395 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AOQ80_03400 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOQ80_03415 ENOG4105BZU Histidine kinase AOQ80_03420 ENOG4105D5Q Arginine ornithine antiporter AOQ80_03425 ENOG4107414 GntR family transcriptional regulator AOQ80_03430 ENOG4105C5Y PTS System AOQ80_03435 ENOG4105CG3 alpha amylase, catalytic region AOQ80_03450 ENOG4105E1K spore germination protein AOQ80_03460 ENOG4105CRN Aminoglycoside phosphotransferase AOQ80_03465 ENOG4105BZG amino acid carrier protein AOQ80_03470 ENOG4105CDA abc transporter atp-binding protein AOQ80_03475 ENOG4105CT1 (ABC) transporter AOQ80_03480 ENOG4105EAD ABC transporter AOQ80_03485 ENOG4105DRP amino acid AbC transporter AOQ80_03490 ENOG4108IQI permease AOQ80_03515 ENOG4105D29 Helix-turn-helix type 11 domain protein AOQ80_03520 ENOG4105NAE bifunctional deaminase-reductase domain protein AOQ80_03525 ENOG4105BZU Histidine kinase AOQ80_03540 ENOG4105CHH sulfate transporter AOQ80_03545 ENOG41068KF Universal stress protein AOQ80_03555 ENOG4105DEF Extracellular solute-binding protein, family 5 AOQ80_03565 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOQ80_03570 ENOG4108JQ7 (ABC) transporter AOQ80_03575 ENOG4105C3U ABC transporter AOQ80_03580 ENOG4105CXY transporter AOQ80_03585 ENOG41067TZ transcriptional regulator, MarR family AOQ80_03590 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOQ80_03595 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOQ80_03600 ENOG4105ETE Transcriptional regulator (LacI family AOQ80_03605 ENOG4108RVA ribokinase AOQ80_03615 ENOG4105C2J ABC transporter AOQ80_03620 ENOG4105CNN ABC, transporter AOQ80_03625 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AOQ80_03630 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AOQ80_03690 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOQ80_03695 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AOQ80_03700 ENOG41069ER domain protein AOQ80_03705 ENOG4105VZ8 Transcriptional regulator AOQ80_03710 ENOG4107D63 AOQ80_03720 ENOG4105DUX Transporter AOQ80_03740 ENOG4105C85 amino acid AOQ80_03745 ENOG4105C7N Xanthine uracil vitamin C permease AOQ80_03785 ENOG4105BZ9 Cytochrome C oxidase, subunit I AOQ80_03790 ENOG4105E2S oxidase) subunit II AOQ80_03795 ENOG4108IQI permease AOQ80_03810 ENOG4106CAD Protein of unknown function (DUF3311) AOQ80_03815 ENOG4105E1V na solute symporter AOQ80_03830 ENOG4108NHD germination protein AOQ80_03840 ENOG4105CE1 Ferrous iron transport protein b AOQ80_03845 ENOG4105CE1 Ferrous iron transport protein b AOQ80_03850 ENOG4105CE1 Ferrous iron transport protein b AOQ80_03855 ENOG4105CVA phosphate AOQ80_03860 ENOG4105C8U phosphate abc transporter AOQ80_03865 ENOG4105E2Z phosphate ABC transporter (Permease AOQ80_03990 ENOG41080XQ Signal transduction protein with cbs domains AOQ80_04015 ENOG4105ETU transcriptional activator (TenA AOQ80_04025 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AOQ80_04035 ENOG4108VEU Thiamine monophosphate synthase AOQ80_04040 ENOG41080HI glycine oxidase AOQ80_04055 ENOG4105D06 uba thif-type nad fad binding protein AOQ80_04060 ENOG4105DWF phosphomethylpyrimidine kinase AOQ80_04105 ENOG4108INS Transcriptional regulator AOQ80_04120 ENOG4105C7N Xanthine uracil vitamin C permease AOQ80_04150 ENOG4105C5Y PTS System AOQ80_04210 ENOG4107Y03 Nitroreductase AOQ80_04215 ENOG4105ED1 spovr family AOQ80_04240 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AOQ80_04245 ENOG4105XTG Pfam:DUF156 AOQ80_04250 ENOG4105VFE sira family AOQ80_04255 ENOG4107TPS domain protein AOQ80_04260 ENOG4105VFE sira family AOQ80_04265 ENOG41085GJ domain protein AOQ80_04275 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AOQ80_04280 ENOG41087NI Sulfite exporter TauE/SafE AOQ80_04290 ENOG4108KGH TRANSCRIPTIONal AOQ80_04315 ENOG4105EMD TRANSCRIPTIONal AOQ80_04320 ENOG4105VCP PTS System AOQ80_04325 ENOG4105VZJ PTS System AOQ80_04345 ENOG41069ER domain protein AOQ80_04350 ENOG4107RBB ABC transporter, permease AOQ80_04355 ENOG4105C19 ABC transporter AOQ80_04385 ENOG4105WEF catalase AOQ80_04420 ENOG4107T5V SNARE associated Golgi AOQ80_04455 ENOG4105CUB amino acid AOQ80_04460 ENOG4107RWR Sodium hydrogen exchanger AOQ80_04470 ENOG4106KNT transcriptional regulator AOQ80_04505 ENOG4108PCN EamA-like transporter family AOQ80_04510 ENOG4108YXU transcriptional regulator AsnC family AOQ80_04520 ENOG4105KPY Small multidrug resistance protein AOQ80_04525 ENOG4105KPY Small multidrug resistance protein AOQ80_04550 ENOG4105NF4 modulator of drug activity AOQ80_04555 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AOQ80_04560 ENOG4105E5W Transporter AOQ80_04570 ENOG4107RKG DJ-1/PfpI family AOQ80_04575 ENOG4105CH6 catalase AOQ80_04585 ENOG4105D5Q Arginine ornithine antiporter AOQ80_04590 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AOQ80_04600 ENOG4105C26 Dehydrogenase AOQ80_04610 ENOG4105BZ1 (ABC) transporter AOQ80_04625 ENOG4105DRP amino acid AbC transporter AOQ80_04630 ENOG4105CDA abc transporter atp-binding protein AOQ80_04645 ENOG410839P AOQ80_04680 ENOG4107FQX Alpha-acetolactate decarboxylase AOQ80_04710 ENOG4105D4P Coproporphyrinogen iii oxidase AOQ80_04725 ENOG4105CHH sulfate transporter AOQ80_04765 ENOG4106AKK s-layer domain-containing protein AOQ80_04775 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOQ80_04780 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOQ80_04795 ENOG4105CGU Enoyl-CoA hydratase AOQ80_04815 ENOG4105DER m42 family AOQ80_04835 ENOG4105CTU Proline racemase AOQ80_04880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOQ80_04890 ENOG4108JQ7 (ABC) transporter AOQ80_04920 ENOG4105CSH Transporter AOQ80_04930 ENOG4108MRH transcriptional regulatory protein AOQ80_04980 ENOG4105CDU Replicative dna helicase AOQ80_05020 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOQ80_05070 ENOG4107P5I polyketide synthase AOQ80_05075 ENOG4108IG5 Transcriptional regulator AOQ80_05095 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AOQ80_05115 ENOG4105CMT Dihydroxyacetone kinase AOQ80_05130 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AOQ80_05135 ENOG410847I Transcriptional regulator, BadM Rrf2 family AOQ80_05160 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AOQ80_05225 ENOG4105WN5 stage II sporulation protein AOQ80_05235 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOQ80_05245 ENOG4108MJI response regulator AOQ80_05250 ENOG4105BZU Histidine kinase AOQ80_05255 ENOG4105BZU Histidine kinase AOQ80_05280 ENOG4105K8R UPF0145 protein AOQ80_05315 ENOG4107VRP DNA repair exonuclease AOQ80_05320 ENOG4106D4I domain protein AOQ80_05325 ENOG4105D7V transposase AOQ80_05340 ENOG4108IND Tetr family transcriptional regulator AOQ80_05345 ENOG4105EQ0 Major Facilitator superfamily AOQ80_05365 ENOG4108MUZ hydrolase AOQ80_05385 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AOQ80_05400 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AOQ80_05415 ENOG4105EMN RNA polymerase sigma factor AOQ80_05440 ENOG4105C57 major facilitator superfamily AOQ80_05445 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOQ80_05455 ENOG4105EEM helicase AOQ80_05460 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOQ80_05490 ENOG4105K59 histidine triad (HIT) protein AOQ80_05520 ENOG410905X membrane-flanked domain protein AOQ80_05530 ENOG4105CKV Membrane AOQ80_05570 ENOG410905X membrane-flanked domain protein AOQ80_05575 ENOG4105CKV Membrane AOQ80_05580 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AOQ80_05585 ENOG4105BZ4 penicillin-binding protein AOQ80_05590 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AOQ80_05600 ENOG4105C1Q protoporphyrinogen oxidase AOQ80_05625 ENOG4105NA0 Transcriptional regulator AOQ80_05640 ENOG4105ECB domain protein AOQ80_05670 ENOG4106AXD AOQ80_05675 ENOG4108RQ5 Beta-lactamase domain-containing protein AOQ80_05680 ENOG4105DF9 Lipoate-protein, ligase AOQ80_05690 ENOG4105CEY Amp-dependent synthetase and ligase AOQ80_05720 ENOG4105CNA YD repeat protein AOQ80_05755 ENOG4105ENX hydrolase AOQ80_05765 ENOG4107RN3 metallophosphoesterase AOQ80_05770 ENOG4107TVP HD domain protein AOQ80_05780 ENOG4108AEY RNA polymerase sigma factor AOQ80_05785 ENOG41086D8 Transcriptional regulator AOQ80_05805 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOQ80_05830 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AOQ80_05835 ENOG4105C8Q Methyl-accepting chemotaxis AOQ80_05855 ENOG4105ZU5 s-layer protein AOQ80_05860 ENOG4107QP3 malate synthase g AOQ80_05875 ENOG4105VEQ Cold shock protein AOQ80_05890 ENOG4105XVF Competence transcription factor AOQ80_05905 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AOQ80_05910 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AOQ80_05955 ENOG4105ERH Fumarylacetoacetate hydrolase AOQ80_05980 ENOG4105CAQ asparagine synthetase AOQ80_05985 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AOQ80_05990 ENOG4105CH6 catalase AOQ80_05995 ENOG4105BZU Histidine kinase AOQ80_06020 ENOG4105QNR S1 RNA binding domain protein AOQ80_06030 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOQ80_06040 ENOG4107AYK membrAne AOQ80_06045 ENOG41073B9 AOQ80_06055 ENOG4108KP7 hydrolase AOQ80_06070 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AOQ80_06095 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOQ80_06100 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AOQ80_06115 ENOG4105C31 Tryptophanyl-tRNA synthetase AOQ80_06130 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOQ80_06135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOQ80_06145 ENOG4108JQ7 (ABC) transporter AOQ80_06150 ENOG4105UQX Mate efflux family protein AOQ80_06175 ENOG4108ZCF integral membrane protein AOQ80_06185 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOQ80_06195 ENOG4105DPN Oligoendopeptidase f AOQ80_06210 ENOG4108Z18 K06886 hemoglobin AOQ80_06215 ENOG4105MIX Adenylate cyclase AOQ80_06230 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AOQ80_06235 ENOG4105EMS pseudouridine synthase AOQ80_06255 ENOG4105K64 Glycosyl transferase, family 2 AOQ80_06275 ENOG4107TVC Glycosyl transferase, family 2 AOQ80_06295 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AOQ80_06300 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AOQ80_06310 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AOQ80_06360 ENOG4108WVJ 2'-5' rna ligase AOQ80_06385 ENOG4105CK7 Sodium proline symporter AOQ80_06395 ENOG4105CRQ synthase (Component I) AOQ80_06400 ENOG4105DDQ anthranilate synthase AOQ80_06490 ENOG4105C7S Dehydrogenase AOQ80_06500 ENOG4105VZ8 Transcriptional regulator AOQ80_06560 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AOQ80_06570 ENOG4105DZ1 carboxypeptidase AOQ80_06575 ENOG4105VFR signal peptidase AOQ80_06610 ENOG4105C26 Dehydrogenase AOQ80_06615 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOQ80_06620 ENOG4105F38 ABC transporter, permease AOQ80_06625 ENOG4105D38 putrescine abc transporter AOQ80_06630 ENOG4107RUE extracellular solute-binding protein family 1 AOQ80_06640 ENOG4105EYF MMPL domain protein AOQ80_06650 ENOG4108YBP pseudouridine synthase AOQ80_06660 ENOG4105K4I Scp-like extracellular AOQ80_06665 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AOQ80_06670 ENOG4105CQB FAD linked oxidase domain protein AOQ80_06685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOQ80_06690 ENOG4105BZU Histidine kinase AOQ80_06695 ENOG4105JXH GntR family transcriptional regulator AOQ80_06715 ENOG4106A3R peptidase AOQ80_06725 ENOG4108QTI )-transporter AOQ80_06730 ENOG4107TS3 membrane protein, TerC AOQ80_06735 ENOG4105CZN Potassium uptake protein AOQ80_06740 ENOG410681C small acid-soluble spore protein AOQ80_06745 ENOG4108Z7G MaoC domain protein dehydratase AOQ80_06765 ENOG4105CHR reductase AOQ80_06775 ENOG4105MWK D-amino acid dehydrogenase, small subunit AOQ80_06795 ENOG4105C4Y ABC transporter AOQ80_06810 ENOG4107RCV ABC transporter, permease AOQ80_06815 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AOQ80_06830 ENOG4105E98 transcriptional regulator DeoR family AOQ80_06855 ENOG4105PXI polysaccharide deacetylase AOQ80_06865 ENOG4105BZU Histidine kinase AOQ80_06870 ENOG41090MY MarR family Transcriptional regulator AOQ80_06880 ENOG4106DF1 AOQ80_06890 ENOG4105BZU Histidine kinase AOQ80_06900 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AOQ80_06905 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AOQ80_06950 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AOQ80_06970 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AOQ80_06975 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AOQ80_06980 ENOG4105CZV ABC transporter AOQ80_06990 ENOG4105CJ1 ABC, transporter AOQ80_07030 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AOQ80_07035 ENOG4105EA8 2-Nitropropane dioxygenase AOQ80_07040 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AOQ80_07050 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOQ80_07075 ENOG4105NQC Flavodoxin AOQ80_07110 ENOG4107QMU Mate efflux family protein AOQ80_07115 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOQ80_07145 ENOG4105CZN Potassium uptake protein AOQ80_07150 ENOG41063Y9 AOQ80_07155 ENOG4105KBJ sporulation protein ytfj AOQ80_07185 ENOG4105CM2 brancheD-chain amino acid aminotransferase AOQ80_07190 ENOG4105C7K acetolactate synthase AOQ80_07195 ENOG4108ZP8 Acetolactate synthase small subunit AOQ80_07200 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AOQ80_07210 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AOQ80_07235 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AOQ80_07270 ENOG4107RVV histidinol phosphate phosphatase, hisj family AOQ80_07285 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AOQ80_07290 ENOG4105E0M Sulfatase AOQ80_07300 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AOQ80_07320 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AOQ80_07325 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AOQ80_07335 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AOQ80_07340 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AOQ80_07345 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AOQ80_07355 ENOG4105C8J )-transporter AOQ80_07375 ENOG4105DFD Na H antiporter AOQ80_07395 ENOG4105ENE Histidine kinase AOQ80_07400 ENOG4105WH1 Two component transcriptional regulator luxr family AOQ80_07420 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AOQ80_07445 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AOQ80_07470 ENOG4105CJ3 phosphate transporter AOQ80_07475 ENOG4107GRR phosphate transport regulator AOQ80_07480 ENOG4105BZ4 penicillin-binding protein AOQ80_07495 ENOG4105BZU Histidine kinase AOQ80_07500 ENOG4105I3N Conserved Protein AOQ80_07515 ENOG4105BZU Histidine kinase AOQ80_07550 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOQ80_07555 ENOG4105DZ1 carboxypeptidase AOQ80_07560 ENOG4108JIC nucleoside recognition domain protein AOQ80_07570 ENOG4105FE9 pseudouridine synthase AOQ80_07580 ENOG4107TWT Cytochrome c biogenesis protein AOQ80_07585 ENOG4105CRE cytochrome C AOQ80_07590 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOQ80_07595 ENOG4105BZU Histidine kinase AOQ80_07600 ENOG4108WBT adenosyltransferase AOQ80_07615 ENOG4108SAX Membrane AOQ80_07625 ENOG4105T7X AOQ80_07630 ENOG4105C9U ATP-dependent DNA helicase RecQ AOQ80_07635 ENOG4105I7S Abortive infection protein AOQ80_07650 ENOG4107X2D transcriptional regulator, merr family AOQ80_07655 ENOG4108S6Z Negative regulator of genetic competence AOQ80_07680 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AOQ80_07685 ENOG4107RB3 L-asparaginase AOQ80_07720 ENOG4105S2F AOQ80_07725 ENOG41065D1 AOQ80_07755 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AOQ80_07770 ENOG4105XXQ heptaprenyl diphosphate synthase component I AOQ80_07780 ENOG4105EAH synthase AOQ80_07800 ENOG4105CIH Imidazole acetol-phosphate transaminase AOQ80_07805 ENOG41068YB TPR repeat-containing protein AOQ80_07820 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AOQ80_07825 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AOQ80_07830 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AOQ80_07860 ENOG4108JYZ YitT family AOQ80_07870 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AOQ80_07885 ENOG4105FJR Lmbe family AOQ80_07890 ENOG4105CPK Glycosyl transferase (Group 1 AOQ80_07930 ENOG4105DVT helicase AOQ80_07935 ENOG4105YAC AOQ80_07955 ENOG4105CSM endonuclease III AOQ80_07965 ENOG4105BZ4 penicillin-binding protein AOQ80_08015 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AOQ80_08025 ENOG4105DVT helicase AOQ80_08030 ENOG4105CTD carboxy-peptidase AOQ80_08045 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AOQ80_08055 ENOG4105C2W permease AOQ80_08060 ENOG4105DHF Membrane AOQ80_08065 ENOG410890F Dynamin family AOQ80_08075 ENOG4108W0I acetyltransferase AOQ80_08085 ENOG4105KHC sulfurtransferase AOQ80_08100 ENOG4106032 Glutathionylspermidine synthase AOQ80_08160 ENOG4105CPK Glycosyl transferase (Group 1 AOQ80_08175 ENOG4108SZE gCN5-related N-acetyltransferase AOQ80_08195 ENOG41081VK Ribonuclease AOQ80_08260 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOQ80_08270 ENOG4107RWR Sodium hydrogen exchanger AOQ80_08275 ENOG4105CN5 Metallo-Beta-Lactamase AOQ80_08280 ENOG4108Z5V transcriptional regulator, merr family AOQ80_08290 ENOG4105H67 Protein of unknown function (DUF421) AOQ80_08295 ENOG41080C8 DUF218 domain AOQ80_08350 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AOQ80_08360 ENOG4107R0U MotA TolQ exbB proton channel AOQ80_08365 ENOG4105ER2 Ompa motb domain protein AOQ80_08370 ENOG4107YTP response regulator receiver protein AOQ80_08380 ENOG4105DD5 Flagellar motor switch protein AOQ80_08395 ENOG4105BZU Histidine kinase AOQ80_08415 ENOG4105E1Q flagellar hook-associated protein AOQ80_08420 ENOG4105DTJ flagellar hook-associated protein AOQ80_08445 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AOQ80_08450 ENOG4108ZC9 flagellar basal-body rod protein flgc AOQ80_08455 ENOG41075Z6 flagellar hook-basal body complex protein fliE AOQ80_08460 ENOG4107U2N Flagellar M-ring protein AOQ80_08470 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AOQ80_08505 ENOG4105BZE flagellar hook protein, FlgE AOQ80_08530 ENOG4105K64 Glycosyl transferase, family 2 AOQ80_08560 ENOG4107TVC Glycosyl transferase, family 2 AOQ80_08585 ENOG4105I03 Flagellin AOQ80_08590 ENOG4105E4C Lytic transglycosylase catalytic AOQ80_08605 ENOG4105DD5 Flagellar motor switch protein AOQ80_08615 ENOG4105CN7 Flagellar biosynthetic protein FliP AOQ80_08620 ENOG4105VS8 Flagellar biosynthetic protein fliq AOQ80_08630 ENOG4105D00 flagellar biosynthetic protein flhB AOQ80_08635 ENOG4105D7B Flagellar biosynthesis protein flha AOQ80_08645 ENOG4105KTQ flagellar basal-body rod protein AOQ80_08650 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOQ80_08675 ENOG4108RZE Tetr family transcriptional regulator AOQ80_08695 ENOG4105KAC Antibiotic biosynthesis monooxygenase AOQ80_08720 ENOG4105DUM transcriptional regulator, lysR family AOQ80_08725 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOQ80_08730 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOQ80_08735 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AOQ80_08740 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AOQ80_08775 ENOG4105CVJ phosphoglycerate mutase AOQ80_08805 ENOG4105CAQ asparagine synthetase AOQ80_08825 ENOG4105PGM cation diffusion facilitator family transporter AOQ80_08835 ENOG4105DRR Transcriptional regulator, GntR family AOQ80_08840 ENOG4108UZ3 Transporter AOQ80_08845 ENOG4105CKI cobalamin synthesis protein AOQ80_08850 ENOG4108PJD permease AOQ80_08865 ENOG4105DFD Na H antiporter AOQ80_08870 ENOG4105C9Q fumarate hydratase class II AOQ80_08900 ENOG4105EC3 peptidase S51, dipeptidase E AOQ80_08920 ENOG4107QIV Cytochrome c biogenesis protein AOQ80_08955 ENOG4106BRA Membrane AOQ80_08990 ENOG4105CJ1 ABC, transporter AOQ80_09010 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AOQ80_09020 ENOG4108IJ0 Aspartate ammonia-lyase AOQ80_09025 ENOG4105C6K Malic enzyme AOQ80_09095 ENOG4105FVX AOQ80_09135 ENOG4105CSR polyphosphate kinase 2 AOQ80_09155 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AOQ80_09170 ENOG4105EU0 Major facilitator Superfamily AOQ80_09175 ENOG4105C6T cysteine synthase AOQ80_09195 ENOG4105C8J )-transporter AOQ80_09205 ENOG4105X5K response regulator receiver protein AOQ80_09210 ENOG4105H67 Protein of unknown function (DUF421) AOQ80_09225 ENOG4106KE4 Dehydrogenase AOQ80_09240 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AOQ80_09245 ENOG4105CHR reductase AOQ80_09250 ENOG4105CM2 brancheD-chain amino acid aminotransferase AOQ80_09255 ENOG4105C7K acetolactate synthase AOQ80_09260 ENOG4108ZP8 Acetolactate synthase small subunit AOQ80_09265 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AOQ80_09275 ENOG4105C7B Threonine dehydratase AOQ80_09300 ENOG4105C6X Major Facilitator AOQ80_09305 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AOQ80_09315 ENOG4105DY9 regulatoR AOQ80_09320 ENOG4105CYC Transferase AOQ80_09340 ENOG4105F6J Alpha beta hydrolase fold AOQ80_09345 ENOG4108J59 Extracellular solute-binding protein, family 5 AOQ80_09375 ENOG41068WN AOQ80_09395 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AOQ80_09400 ENOG4105C72 UPF0176 protein AOQ80_09410 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AOQ80_09445 ENOG4107RHR regulatoR AOQ80_09455 ENOG4105D9N nucleoside AOQ80_09460 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AOQ80_09495 ENOG4107RAQ aminopeptidase AOQ80_09500 ENOG4107STQ Multicopper oxidase AOQ80_09545 ENOG4108T5E Copper resistance protein AOQ80_09550 ENOG4105KTB nuclear export factor GLE1 AOQ80_09560 ENOG4107RT3 EamA-like transporter family AOQ80_09565 ENOG4105GZI Transcriptional regulator AOQ80_09570 ENOG4108Z40 Transcriptional regulator AOQ80_09575 ENOG4107ZXU DSBA oxidoreductase AOQ80_09580 ENOG4108TVJ Nitroreductase AOQ80_09590 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AOQ80_09595 ENOG4106F5Q Membrane AOQ80_09600 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOQ80_09610 ENOG4105CKI cobalamin synthesis protein AOQ80_09630 ENOG4108Z7G MaoC domain protein dehydratase AOQ80_09635 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOQ80_09645 ENOG4105C0Z ABC transporter AOQ80_09650 ENOG4108IV0 ABC, transporter AOQ80_09655 ENOG4105C32 Amino acid ABC transporter (Permease) AOQ80_09665 ENOG4105SKE transcriptional Regulator LysR family AOQ80_09675 ENOG4105MDS 4-oxalocrotonate tautomerase AOQ80_09685 ENOG4105YGB Transcriptional regulator AOQ80_09695 ENOG4105C4M (Ubiquinol oxidase) subunit I AOQ80_09700 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AOQ80_09705 ENOG4108JJ9 ABC, transporter AOQ80_09710 ENOG4108JJ8 (ABC) transporter AOQ80_09755 ENOG4105BZ1 (ABC) transporter AOQ80_09760 ENOG4105BZ1 (ABC) transporter AOQ80_09765 ENOG4105EFI regulatoR AOQ80_09770 ENOG4105BZU Histidine kinase AOQ80_09790 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AOQ80_09795 ENOG4108ZJ4 polysaccharide deacetylase AOQ80_09815 ENOG4105D6E homoserine dehydrogenase AOQ80_09840 ENOG4108KGH TRANSCRIPTIONal AOQ80_09850 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOQ80_09855 ENOG4105BZU Histidine kinase AOQ80_09860 ENOG4107VMI polysaccharide deacetylase AOQ80_09870 ENOG4105KT7 mgtC SapB transporter AOQ80_09875 ENOG4105VRR gCN5-related N-acetyltransferase AOQ80_09885 ENOG4105DUU IucA IucC family protein AOQ80_09890 ENOG4105CEY Amp-dependent synthetase and ligase AOQ80_09905 ENOG4108WBH protein TIM barrel AOQ80_09910 ENOG4105YWU small acid-soluble spore protein AOQ80_09920 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AOQ80_09970 ENOG4105KRN Transcriptional regulator, abrb family AOQ80_09980 ENOG4105YVS arsR family transcriptional regulator AOQ80_09985 ENOG4107SET aldo keto reductase AOQ80_09990 ENOG4107XZQ multidrug resistance protein AOQ80_10015 ENOG4105C8Q Methyl-accepting chemotaxis AOQ80_10035 ENOG4108K88 Membrane AOQ80_10040 ENOG4108WPJ Ferritin-like domain AOQ80_10055 ENOG4105DEN Luciferase family AOQ80_10075 ENOG4107QM2 Aldo Keto reductase AOQ80_10080 ENOG4105CKI cobalamin synthesis protein AOQ80_10145 ENOG4105DSE periplasmic solute binding protein AOQ80_10155 ENOG4105K4T epimerase AOQ80_10165 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AOQ80_10190 ENOG4105CVJ phosphoglycerate mutase AOQ80_10210 ENOG4107T5V SNARE associated Golgi AOQ80_10225 ENOG4108PJD permease AOQ80_10235 ENOG4108S4H thioesterase Superfamily protein AOQ80_10240 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOQ80_10260 ENOG4105SXS Protein of unknown function (DUF456) AOQ80_10265 ENOG4105C37 (CBS) domain AOQ80_10285 ENOG4108Z7R Chaperone CsaA AOQ80_10305 ENOG4108ZRV stage ii sporulation protein p AOQ80_10315 ENOG4108VXD carboxy-peptidase AOQ80_10325 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AOQ80_10350 ENOG4108X4Q Hydrolase AOQ80_10360 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AOQ80_10365 ENOG4107RBS Methyltransferase AOQ80_10380 ENOG41087PP glycosyltransferase MGT family AOQ80_10385 ENOG4108JYZ YitT family AOQ80_10390 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AOQ80_10415 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AOQ80_10465 ENOG4105KBJ sporulation protein ytfj AOQ80_10490 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AOQ80_10510 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AOQ80_10515 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AOQ80_10525 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AOQ80_10530 ENOG4105EMN RNA polymerase sigma factor AOQ80_10555 ENOG4108V06 Glutathione peroxidase AOQ80_10570 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOQ80_10590 ENOG4108IUE nitrate reductase beta subunit AOQ80_10595 ENOG4105R3A Nitrate reductase AOQ80_10620 ENOG4107V6Q Cyclic nucleotide-binding domain AOQ80_10625 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AOQ80_10630 ENOG4105D06 uba thif-type nad fad binding protein AOQ80_10635 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOQ80_10640 ENOG4108ZAF Molybdopterin AOQ80_10665 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AOQ80_10670 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AOQ80_10675 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AOQ80_10680 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AOQ80_10685 ENOG4108IFG nitrite reductase, (NAD(P)H) AOQ80_10690 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AOQ80_10725 ENOG4105MCT stage V sporulation protein S AOQ80_10740 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AOQ80_10760 ENOG4105C5H ABC transporter AOQ80_10775 ENOG4108UUM single-stranded DNA-binding protein AOQ80_10790 ENOG41061H0 Monooxygenase AOQ80_10810 ENOG4107YX5 Pfam:DUF548 AOQ80_10815 ENOG4105C75 arginyL-tRNA synthetase AOQ80_10840 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AOQ80_10855 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AOQ80_10860 ENOG4105C5S asparaginyl-tRNA synthetase AOQ80_10880 ENOG4105EC2 ftsk spoIIIe AOQ80_10975 ENOG4105BZW Glycerate kinase AOQ80_10980 ENOG4107QPK )-transporter AOQ80_10985 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOQ80_10990 ENOG41062D9 Histidine kinase AOQ80_11005 ENOG4105C8J )-transporter AOQ80_11025 ENOG4107XGZ Hydrolase AOQ80_11030 ENOG4105CY2 Citrate transporter AOQ80_11035 ENOG4105C0A alcohol dehydrogenase AOQ80_11050 ENOG4105KD7 acetyltransferase AOQ80_11080 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AOQ80_11100 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AOQ80_11115 ENOG4107RVG penicillin-binding protein AOQ80_11120 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AOQ80_11125 ENOG4105E9Q Acyl-transferase AOQ80_11130 ENOG4108UT2 hemolysin iii AOQ80_11140 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AOQ80_11150 ENOG4108RCR degv family AOQ80_11155 ENOG4105E8R UPF0173 metal-dependent hydrolase AOQ80_11160 ENOG4108KF3 Electron transport protein SCO1 SenC AOQ80_11165 ENOG4107Y70 Heat shock protein AOQ80_11170 ENOG4105CAQ asparagine synthetase AOQ80_11190 ENOG4108MES Periplasmic binding protein AOQ80_11195 ENOG4105F0I Aminotransferase AOQ80_11230 ENOG4105D8X mechanosensitive ion channel AOQ80_11235 ENOG4105BZU Histidine kinase AOQ80_11240 ENOG4105WH1 Two component transcriptional regulator luxr family AOQ80_11250 ENOG4106KNT transcriptional regulator AOQ80_11285 ENOG4105CMG Carbohydrate kinase AOQ80_11290 ENOG4105CMG Carbohydrate kinase AOQ80_11320 ENOG4108IJ8 ABC transporter AOQ80_11325 ENOG4105E90 ABC transporter AOQ80_11360 ENOG4105C37 (CBS) domain AOQ80_11385 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOQ80_11400 ENOG4107S4Y M20 DapE family protein YgeY AOQ80_11405 ENOG4108TSC N-acetyltransferase AOQ80_11410 ENOG4108JUB Transcriptional regulator AOQ80_11415 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AOQ80_11455 ENOG4108N23 SpoOM-related protein AOQ80_11460 ENOG410841Q phosphoesterase PA-phosphatase related protein AOQ80_11470 ENOG4105SZ6 Thioredoxin AOQ80_11485 ENOG4108IBT Inherit from COG: transposase AOQ80_11585 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOQ80_11625 ENOG4105BZ4 penicillin-binding protein AOQ80_11635 ENOG4105CZM Major Facilitator AOQ80_11640 ENOG4105W8X HesB YadR YfhF-family protein AOQ80_11650 ENOG4105DXD 2-methylcitrate dehydratase AOQ80_11655 ENOG4105CR4 methylisocitrate lyase AOQ80_11660 ENOG4105C1G acyl-Coa dehydrogenase AOQ80_11665 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AOQ80_11675 ENOG4105N14 lysine exporter protein LysE YggA AOQ80_11680 ENOG4105E39 Enoyl-CoA hydratase AOQ80_11695 ENOG4107RFY SbcCD D subunit AOQ80_11700 ENOG4105EYH Exonuclease AOQ80_11730 ENOG4105FCD Major Facilitator AOQ80_11735 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AOQ80_11740 ENOG4105E4F Isochorismate synthase AOQ80_11745 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AOQ80_11750 ENOG4105WQI isochorismatase AOQ80_11755 ENOG4105CEY Amp-dependent synthetase and ligase AOQ80_11760 ENOG4105WQT MbtH domain protein AOQ80_11765 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOQ80_11780 ENOG4105K70 DNA-binding protein AOQ80_11800 ENOG4105BZG amino acid carrier protein AOQ80_11825 ENOG4105FE9 pseudouridine synthase AOQ80_11830 ENOG4105C22 threonyL-tRNA synthetase AOQ80_11845 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AOQ80_11870 ENOG4108D32 Methyltransferase AOQ80_11900 ENOG41081I9 integral membrane protein AOQ80_11915 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AOQ80_11925 ENOG4105EYF MMPL domain protein AOQ80_11950 ENOG4105WCN acetyltransferase AOQ80_11980 ENOG4105C1Q protoporphyrinogen oxidase AOQ80_11990 ENOG41068WN AOQ80_12000 ENOG4105VEQ Cold shock protein AOQ80_12020 ENOG410667J hydrolase AOQ80_12065 ENOG4107V2S Transcriptional regulator AOQ80_12070 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AOQ80_12085 ENOG4105DND Transcriptional regulator AOQ80_12090 ENOG4108RPX mosc domain containing protein AOQ80_12105 ENOG4105BZ1 (ABC) transporter AOQ80_12110 ENOG4105BZ1 (ABC) transporter AOQ80_12130 ENOG4108JCI Transcriptional regulator AOQ80_12160 ENOG4108KPJ rna polymerase sigma factor AOQ80_12185 ENOG4105F32 YngK protein AOQ80_12210 ENOG4105RD7 BadF BadG BcrA BcrD AOQ80_12220 ENOG4107STF Involved in phosphonate degradation (By similarity) AOQ80_12240 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AOQ80_12255 ENOG4105C1J atp-dependent rna helicase AOQ80_12270 ENOG4108RZE Tetr family transcriptional regulator AOQ80_12290 ENOG41088CC tellurite resistance protein tehB AOQ80_12300 ENOG4108I0C methyltransferase AOQ80_12305 ENOG4107RA9 decarboxylase AOQ80_12310 ENOG41090HR transcriptional regulator AOQ80_12350 ENOG4105CIN aminoacyl-histidine dipeptidase AOQ80_12375 ENOG4107RF6 penicillin-binding protein AOQ80_12390 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AOQ80_12395 ENOG4105ETE Transcriptional regulator (LacI family AOQ80_12400 ENOG4105IE8 Alpha-ketoglutarate permease AOQ80_12405 ENOG4105CK5 oxidoreductase AOQ80_12430 ENOG4105D2N Aldolase AOQ80_12435 ENOG4105DH8 myo-inositol catabolism AOQ80_12450 ENOG4105CGH 5'-nucleotidase AOQ80_12460 ENOG4105CGH 5'-nucleotidase AOQ80_12475 ENOG4105VZ8 Transcriptional regulator AOQ80_12490 ENOG4108VXD carboxy-peptidase AOQ80_12510 ENOG41067SE Tetr family transcriptional regulator AOQ80_12515 ENOG4105C5H ABC transporter AOQ80_12525 ENOG4105BZU Histidine kinase AOQ80_12535 ENOG4106ANW SMI1_KNR4 AOQ80_12540 ENOG4105CEP NADH dehydrogenase AOQ80_12545 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AOQ80_12560 ENOG4105CJ1 ABC, transporter AOQ80_12570 ENOG4107Z3H Transcriptional regulator, TetR family AOQ80_12585 ENOG4105C1G acyl-Coa dehydrogenase AOQ80_12590 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AOQ80_12595 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AOQ80_12600 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AOQ80_12605 ENOG4105E39 Enoyl-CoA hydratase AOQ80_12610 ENOG4107QX3 carboxylase AOQ80_12615 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AOQ80_12625 ENOG4105WCN acetyltransferase AOQ80_12630 ENOG4105DBI uridine monophosphokinase AOQ80_12665 ENOG4105T9C HD domain AOQ80_12675 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AOQ80_12715 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOQ80_12715 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOQ80_12730 ENOG4105FQP Beta-lactamase AOQ80_12740 ENOG4107Y80 Major Facilitator superfamily AOQ80_12760 ENOG4105CUV Homoserine Kinase AOQ80_12795 ENOG4105CPQ Dehydrogenase AOQ80_12810 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOQ80_12815 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOQ80_12910 ENOG4105ETU transcriptional activator (TenA AOQ80_13020 ENOG410667J hydrolase AOQ80_13030 ENOG4105BZU Histidine kinase AOQ80_13035 ENOG4107RF6 penicillin-binding protein AOQ80_13055 ENOG4108JJB ABC transporter AOQ80_13065 ENOG4108HGU Histidine kinase AOQ80_13080 ENOG4105CB2 alcohol dehydrogenase AOQ80_13085 ENOG4105CJN penicillin-binding protein AOQ80_13095 ENOG4105FQP Beta-lactamase AOQ80_13130 ENOG4108V4B ThiJ pfpI AOQ80_13160 ENOG4107Y80 Major Facilitator superfamily AOQ80_13175 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AOQ80_13195 ENOG4107Y9U Membrane AOQ80_13230 ENOG4105FCD Major Facilitator AOQ80_13245 ENOG4105E09 nadh pyrophosphatase AOQ80_13250 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AOQ80_13255 ENOG4108Z4K mutator MutT protein AOQ80_13290 ENOG4108XI2 Domain of unknown function (DUF1963) AOQ80_13320 ENOG4108NRW Phospholipase, patatin family AOQ80_13325 ENOG4105KWG Pfam:DUF1696 AOQ80_13360 ENOG4105PKS Excinuclease abc c subunit domain protein AOQ80_13400 ENOG4107VFR oxidoreductase AOQ80_13425 ENOG4105PAD Hydrolase AOQ80_13445 ENOG4105DY8 decarboxylase AOQ80_13460 ENOG4108IUM Glycogen debranching enzyme AOQ80_13485 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AOQ80_13495 ENOG4105FDR Membrane AOQ80_13530 ENOG4108V3A UPF0421 protein AOQ80_13550 ENOG4105MSI germination protein ypeb AOQ80_13570 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AOQ80_13575 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AOQ80_13580 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AOQ80_13585 ENOG4107Z3H Transcriptional regulator, TetR family AOQ80_13615 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AOQ80_13635 ENOG4105E98 transcriptional regulator DeoR family AOQ80_13655 ENOG41062ES Transcriptional regulator AOQ80_13675 ENOG4107QKR Dehydrogenase AOQ80_13685 ENOG4107RUY (E1 component), alpha subunit AOQ80_13695 ENOG4105E1F short-chain dehydrogenase reductase AOQ80_13700 ENOG4105RHY Pfam:UPF0157 AOQ80_13735 ENOG4107SQ8 Glycine betaine AOQ80_13740 ENOG4108IJ7 Glycine betaine AOQ80_13765 ENOG4105E66 phosphoriboisomerase A AOQ80_13770 ENOG41082BV acetyltransferase AOQ80_13775 ENOG4108M1A Chitin-binding protein AOQ80_13820 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AOQ80_13870 ENOG4105EEM helicase AOQ80_13890 ENOG4105C9U ATP-dependent DNA helicase RecQ AOQ80_13945 ENOG4108M1A Chitin-binding protein AOQ80_13960 ENOG4105BZG amino acid carrier protein AOQ80_13965 ENOG4105C26 Dehydrogenase AOQ80_13970 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AOQ80_13975 ENOG4105CTU Proline racemase AOQ80_13980 ENOG4105CTU Proline racemase AOQ80_13985 ENOG41080HI glycine oxidase AOQ80_14025 ENOG4107T5V SNARE associated Golgi AOQ80_14040 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AOQ80_14045 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AOQ80_14060 ENOG4105DTQ mandelate racemase muconate lactonizing AOQ80_14100 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AOQ80_14105 ENOG4105BZU Histidine kinase AOQ80_14110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOQ80_14150 ENOG4105EPR degv family AOQ80_14190 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AOQ80_14195 ENOG4106K7D Major facilitator family transporter AOQ80_14215 ENOG4107BMA Transglycosylase associated protein AOQ80_14230 ENOG41089UC methyltransferase, type 11 AOQ80_14265 ENOG4105CHM Aminotransferase AOQ80_14300 ENOG4105DVE abc transporter atp-binding protein AOQ80_14350 ENOG4105C02 permease AOQ80_14365 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AOQ80_14370 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AOQ80_14375 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AOQ80_14400 ENOG4105E09 nadh pyrophosphatase AOQ80_14420 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AOQ80_14470 ENOG4107VC0 DNA alkylation repair enzyme AOQ80_14480 ENOG4107VMI polysaccharide deacetylase AOQ80_14490 ENOG4108ZCF integral membrane protein AOQ80_14495 ENOG4105E0M Sulfatase AOQ80_14500 ENOG4105C5H ABC transporter AOQ80_14510 ENOG4105EYF MMPL domain protein AOQ80_14515 ENOG4105EYF MMPL domain protein AOQ80_14520 ENOG4105EYF MMPL domain protein AOQ80_14525 ENOG41082JN Transcriptional regulator AOQ80_14545 ENOG4105CIH Imidazole acetol-phosphate transaminase AOQ80_14550 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AOQ80_14555 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AOQ80_14590 ENOG41069ER domain protein AOQ80_14600 ENOG4105EMN RNA polymerase sigma factor AOQ80_14625 ENOG4105D4B ABC, transporter AOQ80_14635 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AOQ80_14645 ENOG4105DKT Transcriptional regulator AOQ80_14660 ENOG41061GT Aldolase AOQ80_14680 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AOQ80_14710 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AOQ80_14715 ENOG4105II7 pyrroline-5-carboxylate reductase AOQ80_14725 ENOG4107258 Transcriptional regulator AOQ80_14735 ENOG4105E0Y RtcB Protein AOQ80_14740 ENOG4105ECK Fatty Acid Desaturase AOQ80_14745 ENOG4105G6Z alkaline phosphatase AOQ80_14755 ENOG4105VMP Transcriptional regulator AOQ80_14770 ENOG41090T1 Membrane AOQ80_14780 ENOG4108WCX response regulator AOQ80_14790 ENOG41068WN AOQ80_14815 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOQ80_14840 ENOG4105CKK Glycosyl transferase, family 2 AOQ80_14865 ENOG4105CKK Glycosyl transferase, family 2 AOQ80_14875 ENOG4105C8Y Acetylornithine aminotransferase AOQ80_14915 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOQ80_14925 ENOG4108TVJ Nitroreductase AOQ80_14930 ENOG4105FS7 Transcriptional regulator AOQ80_14965 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOQ80_14975 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AOQ80_15005 ENOG4108XET gCN5-related N-acetyltransferase AOQ80_15085 ENOG410635A Membrane AOQ80_15090 ENOG4105KNA -acetyltransferase AOQ80_15095 ENOG4108IQI permease AOQ80_15105 ENOG4105F1N DNA alkylation repair AOQ80_15145 ENOG4107RF6 penicillin-binding protein AOQ80_15155 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AOQ80_15195 ENOG4105P4J Allophanate hydrolase, subunit 1 AOQ80_15200 ENOG4107258 Transcriptional regulator AOQ80_15210 ENOG4106N3A copper homeostasis protein cutc AOQ80_15215 ENOG4108ZRV stage ii sporulation protein p AOQ80_15220 ENOG4108ZHR arsR family transcriptional regulator AOQ80_15230 ENOG4105FDT acyl-CoA dehydrogenase AOQ80_15250 ENOG4105DWD nucleoside recognition domain protein AOQ80_15280 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AOQ80_15345 ENOG4105E2A Dehydrogenase AOQ80_15360 ENOG4108IJ0 Aspartate ammonia-lyase AOQ80_15365 ENOG4105HDK L-asparaginase AOQ80_15370 ENOG4108IMY Transcriptional regulator AOQ80_15380 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AOQ80_15385 ENOG4105CUB amino acid AOQ80_15395 ENOG4105II7 pyrroline-5-carboxylate reductase AOQ80_15405 ENOG4105C6K Malic enzyme AOQ80_15415 ENOG4108NHD germination protein AOQ80_15420 ENOG4108NHD germination protein AOQ80_15425 ENOG4108Q8B Spore germination protein AOQ80_15445 ENOG4105CSV Glutaminase AOQ80_15475 ENOG4105CGH 5'-nucleotidase AOQ80_15480 ENOG4105CH6 catalase AOQ80_15490 ENOG4105CHJ isochorismatase hydrolase AOQ80_15555 ENOG4108606 TspO/MBR family AOQ80_15560 ENOG4105CVP deoxyribo-dipyrimidine photolyase AOQ80_15575 ENOG4108TWJ NADH dehydrogenase subunit 5 AOQ80_15580 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AOQ80_15590 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AOQ80_15595 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AOQ80_15600 ENOG4105DSE periplasmic solute binding protein AOQ80_15605 ENOG4105CC5 ABC transporter AOQ80_15610 ENOG4105DIK (ABC) transporter AOQ80_15640 ENOG4105D6J arsenicaL-resistance protein AOQ80_15645 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AOQ80_15650 ENOG41085FC arsR family transcriptional regulator AOQ80_15665 ENOG4105F7F Chaperone AOQ80_15675 ENOG4105CHR reductase AOQ80_15680 ENOG4108YXU transcriptional regulator AsnC family AOQ80_15755 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AOQ80_15765 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOQ80_15775 ENOG4105IIP Membrane AOQ80_15790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOQ80_15795 ENOG41062D9 Histidine kinase AOQ80_15825 ENOG4105K6H D-cysteine desulfhydrase AOQ80_15850 ENOG4105VZ8 Transcriptional regulator AOQ80_15865 ENOG4108NNI Beta-lactamase domain-containing protein AOQ80_15870 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AOQ80_15880 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOQ80_15885 ENOG4105JQZ Methyltransferase AOQ80_15900 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AOQ80_15905 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AOQ80_15925 ENOG4105BZU Histidine kinase AOQ80_15940 ENOG4108U05 Transcriptional regulator AOQ80_15955 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AOQ80_15960 ENOG4105DJB Major Facilitator Superfamily AOQ80_15965 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AOQ80_15970 ENOG4107QR9 Iron-sulfur cluster binding protein AOQ80_15980 ENOG4106P55 Transcriptional regulator AOQ80_15990 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AOQ80_16030 ENOG4105TRI Hydrolase AOQ80_16065 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AOQ80_16095 ENOG4107QJQ Mate efflux family protein AOQ80_16110 ENOG4105EQ0 Major Facilitator superfamily AOQ80_16115 ENOG4108JGH Tetr family transcriptional regulator AOQ80_16130 ENOG4105C44 Serine transporter AOQ80_16135 ENOG4105EJQ L-serine dehydratase AOQ80_16150 ENOG4108JPW Aminotransferase AOQ80_16165 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AOQ80_16175 ENOG4105DVH amino acid AOQ80_16190 ENOG4108JQ1 Dehydrogenase AOQ80_16210 ENOG4108AEY RNA polymerase sigma factor AOQ80_16225 ENOG41082W1 Cupin 2, conserved barrel domain protein AOQ80_16235 ENOG410874W AraC family transcriptional regulator AOQ80_16250 ENOG4105HIR S-layer domain protein AOQ80_16290 ENOG4108ISG Major Facilitator AOQ80_16300 ENOG4107MII Sugar-specific transcriptional regulator TrmB AOQ80_16305 ENOG4105CZM Major Facilitator AOQ80_16325 ENOG4105DA5 (ABC) transporter AOQ80_16330 ENOG41069JR AOQ80_16340 ENOG4105RXJ AOQ80_16345 ENOG4105KPY Small multidrug resistance protein AOQ80_16350 ENOG4105KBX Transcriptional regulator, TetR family AOQ80_16365 ENOG4105CRW Short chain fatty acid transporter AOQ80_16375 ENOG4105DYS nad(p)h dehydrogenase (quinone) AOQ80_16405 ENOG4108JJB ABC transporter AOQ80_16410 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AOQ80_16435 ENOG4108K8S endonuclease I AOQ80_16450 ENOG41067QW Transcriptional regulator AOQ80_16460 ENOG4108Z66 YbaK ebsC protein AOQ80_16465 ENOG4105CUT histidyl-tRNA synthetase AOQ80_16480 ENOG4105KVH Transcriptional regulator AOQ80_16485 ENOG4108RCM Nitroreductase AOQ80_16505 ENOG4108PSK reductase AOQ80_16515 ENOG4105CJ1 ABC, transporter AOQ80_16575 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AOQ80_16580 ENOG4105DKQ ROK family AOQ80_16585 ENOG4106UW1 Major Facilitator superfamily AOQ80_16590 ENOG4108UW5 maltose o-acetyltransferase AOQ80_16605 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AOQ80_16610 ENOG4105C31 Tryptophanyl-tRNA synthetase AOQ80_16615 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AOQ80_16640 ENOG4105DMQ Methyltransferase AOQ80_16650 ENOG4105EV4 Multidrug resistance protein mdtH AOQ80_16680 ENOG4105C37 (CBS) domain AOQ80_16695 ENOG4105DDN Pentapeptide repeat-containing protein AOQ80_16700 ENOG4105XDF Protein of unknown function (DUF1272) AOQ80_16705 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AOQ80_16710 ENOG4105CMG Carbohydrate kinase AOQ80_16715 ENOG4105C6Z Gluconate AOQ80_16720 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AOQ80_16735 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AOQ80_16740 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AOQ80_16745 ENOG4105CIS alcohol dehydrogenase AOQ80_16750 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AOQ80_16770 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AOQ80_16775 ENOG4105D4Y metalloprotease AOQ80_16795 ENOG4105CV8 reductase AOQ80_16800 ENOG4105F27 Major Facilitator AOQ80_16815 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AOQ80_16820 ENOG4105C44 Serine transporter AOQ80_16855 ENOG4105KVH Transcriptional regulator AOQ80_16860 ENOG4108TZY GntR Family Transcriptional Regulator AOQ80_16870 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AOQ80_16875 ENOG4105KVH Transcriptional regulator AOQ80_16880 ENOG4105KVH Transcriptional regulator AOQ80_16915 ENOG4105JAB phenazine biosynthesis protein, phzf family AOQ80_16925 ENOG4105CHR reductase AOQ80_16945 ENOG4105KVH Transcriptional regulator AOQ80_17015 ENOG4105KAF membrAne AOQ80_17040 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AOQ80_17055 ENOG4107YXZ hydrolase, family 25 AOQ80_17080 ENOG4105ED2 Beta-lactamase AOQ80_17090 ENOG4105H3G oxidoreductase AOQ80_17165 ENOG4108TN2 lmbE family AOQ80_17175 ENOG4107R3E Citrate transporter AOQ80_17195 ENOG4108MES Periplasmic binding protein AOQ80_17205 ENOG4105EHG Permease protein AOQ80_17210 ENOG4105DQ5 transport system permease protein AOQ80_17215 ENOG4105NX3 Membrane AOQ80_17220 ENOG4107ZY0 Phenazine biosynthesis-like protein AOQ80_17240 ENOG4107CUJ Protein of unknown function (DUF2690) AOQ80_17250 ENOG4107V2S Transcriptional regulator AOQ80_17270 ENOG4105C98 muts2 protein AOQ80_17280 ENOG4105E5K Alpha-amylase AOQ80_17285 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AOQ80_17290 ENOG4105DPN Oligoendopeptidase f AOQ80_17295 ENOG4108A04 Beta-lactamase AOQ80_17325 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AOQ80_17350 ENOG41082BM Transcriptional regulator, arsr family AOQ80_17355 ENOG4105CIS alcohol dehydrogenase AOQ80_17380 ENOG4105RHY Pfam:UPF0157 AOQ80_17390 ENOG4105C09 Bile acid AOQ80_17395 ENOG4105CQB FAD linked oxidase domain protein AOQ80_17420 ENOG4108UT6 Transferase hexapeptide repeat containing protein AOQ80_17430 ENOG4105K64 Glycosyl transferase, family 2 AOQ80_17435 ENOG4105E39 Enoyl-CoA hydratase AOQ80_17445 ENOG4105KT7 mgtC SapB transporter AOQ80_17455 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOQ80_17460 ENOG41073R8 VanW family AOQ80_17470 ENOG4108R1P AOQ80_17490 ENOG4105VEQ Cold shock protein AOQ80_17510 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AOQ80_17530 ENOG410904N short-chain dehydrogenase reductase AOQ80_17540 ENOG4106IQC argininosuccinate lyase AOQ80_17555 ENOG4108IA2 Sodium pantothenate symporter AOQ80_17565 ENOG4105C26 Dehydrogenase AOQ80_17570 ENOG4105CHR reductase AOQ80_17580 ENOG4105EWU Squalene--hopene cyclase AOQ80_17590 ENOG4105FR1 rard protein AOQ80_17595 ENOG410696E Membrane AOQ80_17610 ENOG4105D1F ATP-binding protein AOQ80_17620 ENOG4108ZAF Molybdopterin AOQ80_17625 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOQ80_17630 ENOG4105D06 uba thif-type nad fad binding protein AOQ80_17635 ENOG4105TMB Formate nitrite transporter AOQ80_17645 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AOQ80_17650 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AOQ80_17660 ENOG4108JB9 formate dehydrogenase AOQ80_17670 ENOG4105E1K spore germination protein AOQ80_17730 ENOG4107QJT sodium dicarboxylate symporter AOQ80_17735 ENOG4108KGH TRANSCRIPTIONal AOQ80_17745 ENOG4105EMN RNA polymerase sigma factor AOQ80_17770 ENOG4105CIG ABC transporter AOQ80_17780 ENOG4105D9R oxidoreductase AOQ80_17790 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOQ80_17800 ENOG4105K4P CoA-binding domain protein AOQ80_17805 ENOG4105C0H protease AOQ80_17810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOQ80_17820 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AOQ80_17825 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AOQ80_17830 ENOG4105W8X HesB YadR YfhF-family protein AOQ80_17860 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AOQ80_17865 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AOQ80_17875 ENOG4108JJA ABC, transporter AOQ80_17880 ENOG4108I0Z Aconitate hydratase AOQ80_17910 ENOG4105E5W Transporter AOQ80_17920 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOQ80_17940 ENOG4107F3J Amp-dependent synthetase and ligase AOQ80_17945 ENOG4107ZYJ bioY protein AOQ80_17950 ENOG4105CEY Amp-dependent synthetase and ligase AOQ80_17995 ENOG4107AYK membrAne AOQ80_18005 ENOG4105BZU Histidine kinase AOQ80_18010 ENOG4105FBA Phospholipase Carboxylesterase AOQ80_18015 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AOQ80_18020 ENOG4105CK7 Sodium proline symporter AOQ80_18025 ENOG4105CBC glutamate synthase AOQ80_18030 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AOQ80_18035 ENOG4108VJ1 Transcriptional regulator (CarD family AOQ80_18040 ENOG4108903 Formimidoylglutamase AOQ80_18065 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AOQ80_18125 ENOG4107QIV Cytochrome c biogenesis protein AOQ80_18135 ENOG4107RSM transcriptional regulator AOQ80_18140 ENOG4105VAW lrga family AOQ80_18145 ENOG41067MG lrgb family AOQ80_18170 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AOQ80_18185 ENOG4105BZ1 (ABC) transporter AOQ80_18190 ENOG4105BZ1 (ABC) transporter AOQ80_18210 ENOG4105D7V transposase AOQ80_18230 ENOG4105D5T phosphonate abc transporter AOQ80_18245 ENOG4105CGH 5'-nucleotidase AOQ80_18255 ENOG4108SVB resolvase AOQ80_18275 ENOG4105K7K Transcriptional regulator AOQ80_18310 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AOQ80_18315 ENOG4105XSJ toxin secretion phage lysis holin AOQ80_18525 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) AOQ80_18630 ENOG4105C5F glutamine synthetase AOQ80_18635 ENOG4105KV4 Transcriptional regulator AOQ80_18640 ENOG4105CXI aluminum resistance protein AOQ80_18650 ENOG4105EN6 Membrane AOQ80_18655 ENOG4106F1P AAA ATPase, central domain protein AOQ80_18685 ENOG41069ER domain protein AOQ80_18690 ENOG4105DM4 PTS System AOQ80_18695 ENOG4105DE4 1-phosphofructokinase AOQ80_18700 ENOG4105E98 transcriptional regulator DeoR family AOQ80_18710 ENOG4108SJC Membrane AOQ80_18725 ENOG4105C85 amino acid AOQ80_18740 ENOG4105TMB Formate nitrite transporter AOQ80_18745 ENOG4105K70 DNA-binding protein AOQ80_18750 ENOG4105C59 p-type ATPase AOQ80_18755 ENOG410681U heavy metal transport detoxification protein AOQ80_18760 ENOG4105VPX protein, conserved in bacteria AOQ80_18770 ENOG4105NIV Esterase AOQ80_18775 ENOG4105E0A ABC, transporter AOQ80_18800 ENOG4105CGK Exodeoxyribonuclease III AOQ80_18810 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AOQ80_18815 ENOG4105D03 DNA-3-methyladenine glycosylase II AOQ80_18845 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AOQ80_18850 ENOG4105BZU Histidine kinase AOQ80_18870 ENOG41067MG lrgb family AOQ80_18885 ENOG4107TTQ Alpha beta hydrolase fold AOQ80_18890 ENOG4107YEI lmbE family AOQ80_18910 ENOG4105F0V Cell wall hydrolase AOQ80_18915 ENOG4107R6R udp-galactopyranose mutase AOQ80_18920 ENOG4105E0M Sulfatase AOQ80_18925 ENOG410890F Dynamin family AOQ80_18935 ENOG4107QHE Choloylglycine hydrolase AOQ80_18960 ENOG4105DA5 (ABC) transporter AOQ80_18985 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AOQ80_18990 ENOG4105DQU oxidoreductase, subunit beta AOQ80_18995 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AOQ80_19000 ENOG4108IGT Dipeptidase AOQ80_19005 ENOG4105MCT stage V sporulation protein S AOQ80_19010 ENOG4105D48 metallophosphoesterase AOQ80_19035 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AOQ80_19050 ENOG4105XZV Protein of unknown function (DUF3243) AOQ80_19055 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AOQ80_19075 ENOG4105UIB (ABC) transporter AOQ80_19080 ENOG4105UIB (ABC) transporter AOQ80_19085 ENOG4108JQ9 ABC transporter AOQ80_19090 ENOG4105DIH basic membrane AOQ80_19095 ENOG4105FDP GntR family transcriptional regulator AOQ80_19100 ENOG4107QZI cell division protein FtsK AOQ80_19110 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AOQ80_19125 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AOQ80_19135 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AOQ80_19140 ENOG4108S0H Dipicolinic acid synthetase, b subunit AOQ80_19145 ENOG4105E35 Dipicolinate synthase subunit A AOQ80_19155 ENOG4105C1V Peptidase, M16 AOQ80_19175 ENOG4105DTN riboflavin biosynthesis protein ribF AOQ80_19180 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AOQ80_19190 ENOG4105W7A Protein of unknown function (DUF503) AOQ80_19200 ENOG4105VHM ribosomal protein AOQ80_19205 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AOQ80_19210 ENOG4105CHV Transcription elongation factor NusA AOQ80_19220 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AOQ80_19230 ENOG4105DZP Membrane-associated zinc metalloprotease AOQ80_19235 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AOQ80_19240 ENOG4105KNE Phosphatidate cytidylyltransferase AOQ80_19245 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AOQ80_19285 ENOG4108HE4 integrase family AOQ80_19295 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AOQ80_19305 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AOQ80_19320 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AOQ80_19345 ENOG4105VB6 UPF0109 protein AOQ80_19365 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AOQ80_19370 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AOQ80_19385 ENOG4105CHR reductase AOQ80_19390 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AOQ80_19405 ENOG4105CB5 ATP-dependent DNA helicase recG AOQ80_19410 ENOG4105DP4 dak2 domain fusion protein ylov AOQ80_19415 ENOG4108ZAA Alkaline-shock protein AOQ80_19430 ENOG4105FJ0 thiamine AOQ80_19435 ENOG4105DJV ribulose-phosphate 3-epimerase AOQ80_19440 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AOQ80_19445 ENOG4105D9P serine threonine protein kinase AOQ80_19450 ENOG4108ZF3 Phosphatase AOQ80_19460 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AOQ80_19470 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AOQ80_19475 ENOG4105C25 Primosomal protein n' AOQ80_19480 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AOQ80_19500 ENOG4105DSJ YicC domain protein AOQ80_19510 ENOG4105F23 Fibronectin-binding protein AOQ80_19515 ENOG4105DC7 peptidase M24 AOQ80_19570 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AOQ80_19595 ENOG4105C34 Pseudouridine synthase AOQ80_19610 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AOQ80_19620 ENOG4105DBK s4 domain protein AOQ80_19625 ENOG41067XK integral membrane protein AOQ80_19635 ENOG4105DFA alanine racemase domain protein AOQ80_19640 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AOQ80_19645 ENOG4105WR5 sporulation protein, YlmC YmxH family AOQ80_19655 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOQ80_19665 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AOQ80_19670 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AOQ80_19675 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AOQ80_19680 ENOG4105D4A Cell wall formation (By similarity) AOQ80_19685 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AOQ80_19690 ENOG4105CNI cell division protein FtsW AOQ80_19705 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOQ80_19710 ENOG4105CJN penicillin-binding protein AOQ80_19715 ENOG4105CJN penicillin-binding protein AOQ80_19720 ENOG41068DC Essential cell division protein (By similarity) AOQ80_19755 ENOG4105KNH Nucleic acid-binding protein AOQ80_19805 ENOG4105XSJ toxin secretion phage lysis holin AOQ80_19890 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AOQ80_19900 ENOG4105CAR Terminase, large subunit AOQ80_19990 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AOQ80_20000 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOQ80_20055 ENOG4108IMY Transcriptional regulator AOQ80_20080 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) AOQ80_20090 ENOG41063PX domain protein AOQ80_20095 ENOG4105D78 K07001 NTE family protein AOQ80_20100 ENOG4105H20 Sporulation integral membrane protein YlbJ AOQ80_20110 ENOG4106H78 methyltransferase AOQ80_20130 ENOG4107TB6 phosphoglycerate mutase AOQ80_20145 ENOG4106UY4 Inherit from COG: Scp-like extracellular AOQ80_20195 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AOQ80_20200 ENOG4105CNI cell division protein FtsW AOQ80_20215 ENOG4108IAB Phoh family AOQ80_20235 ENOG4105QA2 AOQ80_20240 ENOG4105CI3 gtp-binding protein typa AOQ80_20250 ENOG4105ECY inositol monophosphatase AOQ80_20270 ENOG4105CXN decarboxylase AOQ80_20315 ENOG4105C7S Dehydrogenase AOQ80_20320 ENOG4105CPP Dehydrogenase, E1 component AOQ80_20335 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AOQ80_20340 ENOG4108X4Q Hydrolase AOQ80_20350 ENOG4105CN5 Metallo-Beta-Lactamase AOQ80_20355 ENOG4107ZYR domain protein AOQ80_20390 ENOG4108XRC Protein of unknown function (DUF458) AOQ80_20400 ENOG4107IN1 Protein of unknown function (DUF1797) AOQ80_20415 ENOG4105EPM Diguanylate phosphodiesterase AOQ80_20420 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AOQ80_20435 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AOQ80_20445 ENOG4105UIN AOQ80_20510 ENOG4108HGU Histidine kinase AOQ80_20520 ENOG4105CHM Aminotransferase AOQ80_20525 ENOG4105FKQ transcriptional regulator AOQ80_20530 ENOG4105EG2 ABC transporter, permease AOQ80_20540 ENOG4107FKK extracellular solute-binding protein family 1 AOQ80_20550 ENOG4105CG3 alpha amylase, catalytic region AOQ80_20595 ENOG4105CHU acetyl-coa acetyltransferase AOQ80_20635 ENOG4105K7K Transcriptional regulator AOQ80_20640 ENOG4105DTD Dehydrogenase AOQ80_20650 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AOQ80_20660 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AOQ80_20685 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AOQ80_20705 ENOG4106TD9 Diguanylate cyclase AOQ80_20725 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AOQ80_20740 ENOG4105CID antiterminator AOQ80_20750 ENOG4105FDP GntR family transcriptional regulator AOQ80_20760 ENOG4105CE4 GlcNAc 6-P deacetylase AOQ80_20805 ENOG4107ZE5 PPIases accelerate the folding of proteins AOQ80_20810 ENOG4105PTM secreted protein AOQ80_20815 ENOG4105J7I hydrolase AOQ80_20825 ENOG4105G6R Stage v sporulation protein ae AOQ80_20835 ENOG4105CZ3 stage V sporulation protein ad AOQ80_20840 ENOG41090VF Stage v sporulation protein ac AOQ80_20860 ENOG4105C8J )-transporter AOQ80_20865 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOQ80_20875 ENOG41082AN stage II sporulation protein AOQ80_20880 ENOG4105DZ1 carboxypeptidase AOQ80_20885 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOQ80_20890 ENOG4105DVE abc transporter atp-binding protein AOQ80_20925 ENOG4105D7N magnesium and cobalt transport protein CorA AOQ80_20950 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AOQ80_20960 ENOG4105I3K Ferric uptake regulator, Fur family AOQ80_20965 ENOG4105MZ9 stage II sporulation protein m AOQ80_20985 ENOG4105CPC Aldo Keto reductase AOQ80_20995 ENOG4105RHY Pfam:UPF0157 AOQ80_21015 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AOQ80_21025 ENOG4105ETE Transcriptional regulator (LacI family AOQ80_21030 ENOG4108YM7 Gcn5-related n-acetyltransferase AOQ80_21050 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AOQ80_21055 ENOG4108R6K riboflavin synthase, subunit alpha AOQ80_21075 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AOQ80_21080 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOQ80_21085 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOQ80_21090 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AOQ80_21100 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOQ80_21110 ENOG4105DFD Na H antiporter AOQ80_21115 ENOG4105CGH 5'-nucleotidase AOQ80_21155 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AOQ80_21170 ENOG4108IXY short-chain dehydrogenase reductase AOQ80_21175 ENOG41069FQ Metallo-beta-lactamase superfamily AOQ80_21185 ENOG4105II7 pyrroline-5-carboxylate reductase AOQ80_21190 ENOG4105EJQ L-serine dehydratase AOQ80_21215 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AOQ80_21225 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AOQ80_21230 ENOG4105D9U N-acetyltransferase AOQ80_21245 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AOQ80_21250 ENOG4108QEG Membrane AOQ80_21255 ENOG4105CDA abc transporter atp-binding protein AOQ80_21260 ENOG4105E5Q amino acid AbC transporter AOQ80_21265 ENOG4108HW3 (ABC) transporter AOQ80_21275 ENOG4105G7B Protein of unknown function (DUF2992) AOQ80_21295 ENOG4105C7S Dehydrogenase AOQ80_21300 ENOG4105CPP Dehydrogenase, E1 component AOQ80_21320 ENOG4107RDP Dehydrogenase AOQ80_21335 ENOG4108JUB Transcriptional regulator AOQ80_21345 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AOQ80_21360 ENOG4107QQR Sporulation AOQ80_21370 ENOG4105S1Z Stage IV sporulation protein B AOQ80_21375 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AOQ80_21385 ENOG4105DX0 Hemolysin A AOQ80_21395 ENOG4105CTB Polyprenyl synthetase AOQ80_21420 ENOG4108ZSR alkaline shock protein AOQ80_21425 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AOQ80_21450 ENOG410644B Stage III sporulation protein af AOQ80_21460 ENOG4105KQ4 Stage iii sporulation protein ad AOQ80_21465 ENOG4108CQH stage III sporulation protein AC AOQ80_21470 ENOG4105KR5 Stage iii sporulation protein AOQ80_21475 ENOG4105CD2 stage iii sporulation protein aa AOQ80_21500 ENOG4105DC7 peptidase M24 AOQ80_21515 ENOG4105CBJ Metal-dependent enzyme AOQ80_21525 ENOG4107YBY Hydrolase AOQ80_21545 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AOQ80_21550 ENOG4105WZW rhodanese family AOQ80_21570 ENOG41080TC multidrug resistance protein AOQ80_21610 ENOG4105CJ1 ABC, transporter AOQ80_21615 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOQ80_21645 ENOG4105C0D helicase AOQ80_21765 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AOQ80_21770 ENOG4105C3R Methionine synthase AOQ80_21785 ENOG4105C28 cystathionine AOQ80_21790 ENOG4105C28 cystathionine AOQ80_21815 ENOG4105C5X domain protein AOQ80_21825 ENOG4105DKQ ROK family AOQ80_21835 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AOQ80_21850 ENOG4108UTW Plays a role in the regulation of phosphate uptake AOQ80_21855 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AOQ80_21860 ENOG4105E2Z phosphate ABC transporter (Permease AOQ80_21865 ENOG4105C8U phosphate abc transporter AOQ80_21870 ENOG4105PWN phosphate abc transporter AOQ80_21875 ENOG4107RF6 penicillin-binding protein AOQ80_21885 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOQ80_21910 ENOG4105N80 Ferric uptake regulator, Fur family AOQ80_21920 ENOG4105FDK ABC transporter AOQ80_21925 ENOG4108JYZ YitT family AOQ80_21930 ENOG41069ZM Protein of unknown function (DUF2624) AOQ80_21955 ENOG4105EGD dinuclear metal center protein, YbgI family AOQ80_21970 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOQ80_21975 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AOQ80_22010 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AOQ80_22015 ENOG4105KG3 cytidine deaminase AOQ80_22020 ENOG4107YR5 Diacylglycerol kinase AOQ80_22030 ENOG4105CTJ Metal Dependent Phosphohydrolase AOQ80_22035 ENOG4105C9A Phoh family AOQ80_22050 ENOG41068P3 sporulation protein YqfC AOQ80_22055 ENOG4105KTH gatB Yqey AOQ80_22065 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AOQ80_22070 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AOQ80_22090 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AOQ80_22100 ENOG4105CSA Coproporphyrinogen iii oxidase AOQ80_22105 ENOG4105KVH Transcriptional regulator AOQ80_22130 ENOG4105TQK DNA polymerase iii, delta' subunit AOQ80_22140 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AOQ80_22145 ENOG4108UK2 deaminase AOQ80_22150 ENOG4105KQC Competence protein AOQ80_22160 ENOG4105DXX methyltransferase AOQ80_22170 ENOG4108WF2 Metal Dependent Phosphohydrolase AOQ80_22180 ENOG410812S Rna-binding protein AOQ80_22190 ENOG4105CQW ribosome biogenesis GTPase YqeH AOQ80_22195 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AOQ80_22210 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOQ80_22230 ENOG4108TVJ Nitroreductase AOQ80_22245 ENOG4105G6Z alkaline phosphatase AOQ80_22255 ENOG4108MUZ hydrolase AOQ80_22290 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AOQ80_22295 ENOG4105MIR Phenylalanine 4-monooxygenase AOQ80_22305 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOQ80_22310 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOQ80_22350 ENOG4105S6R Iron-hydroxamate transporter permease subunit AOQ80_22355 ENOG4108V5C ABC transporter AOQ80_22365 ENOG4108EKI Dehydrogenase AOQ80_22370 ENOG4105C28 cystathionine AOQ80_22400 ENOG4107XRG penicillin-binding protein AOQ80_22415 ENOG4105CFP Peptidase U32 AOQ80_22420 ENOG4105XYU peptidase (U32 family) AOQ80_22425 ENOG4108VQJ O-methyltransferase AOQ80_22430 ENOG4105HHA aminodeoxychorismate lyase AOQ80_22450 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOQ80_22460 ENOG4105C02 permease AOQ80_22475 ENOG41060CR AOQ80_22480 ENOG4105C7H Helicase, RecD TraA family AOQ80_22490 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AOQ80_22495 ENOG4105C3J Cysteine desulfurase AOQ80_22505 ENOG4105D1H recombination factor protein RarA AOQ80_22510 ENOG4108VCI transcription factor, rsfa family AOQ80_22515 ENOG4105CUZ uba thif-type nad fad binding protein AOQ80_22525 ENOG4105CUT histidyl-tRNA synthetase AOQ80_22540 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AOQ80_22550 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AOQ80_22555 ENOG41076HS cation diffusion facilitator family transporter AOQ80_22560 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AOQ80_22570 ENOG4105CKP Polysaccharide Biosynthesis Protein AOQ80_22575 ENOG4108QG2 Membrane AOQ80_22585 ENOG4105VIE preprotein translocase, subunit YajC AOQ80_22600 ENOG41061AI Protein of unknown function (DUF2905) AOQ80_22615 ENOG4108HUF Transporter AOQ80_22625 ENOG4108IPJ Membrane AOQ80_22630 ENOG4108IPJ Membrane AOQ80_22635 ENOG41082BM Transcriptional regulator, arsr family AOQ80_22660 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AOQ80_22665 ENOG4108IYU L-aspartate oxidase AOQ80_22680 ENOG4108RPX mosc domain containing protein AOQ80_22685 ENOG4105CQC Prephenate dehydratase AOQ80_22705 ENOG4105EWM Histidine kinase AOQ80_22720 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AOQ80_22735 ENOG4105X36 (ribosomal) protein AOQ80_22745 ENOG4105C03 ribonuclease AOQ80_22760 ENOG4107QMS site-determining protein AOQ80_22775 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AOQ80_22780 ENOG4105DFF Rod shape-determining protein mreb AOQ80_22800 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AOQ80_22805 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AOQ80_22815 ENOG41068KH stage VI sporulation protein D AOQ80_22825 ENOG4105D52 delta-aminolevulinic acid dehydratase AOQ80_22850 ENOG4105K56 Transcriptional regulator AOQ80_22870 ENOG4108IUQ atp-dependent protease AOQ80_22900 ENOG4108QCI YvbH-like oligomerisation region AOQ80_22920 ENOG4105M59 Phosphodiesterase, mj0936 family AOQ80_22925 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AOQ80_22935 ENOG4108XJQ germination protein AOQ80_22945 ENOG4108PCX Major Facilitator AOQ80_22955 ENOG4105KBX Transcriptional regulator, TetR family AOQ80_22970 ENOG4105PFC Transcriptional regulator AOQ80_22985 ENOG4105DZC cytosine deaminase AOQ80_22990 ENOG4105DZC cytosine deaminase AOQ80_22995 ENOG4105DEF Extracellular solute-binding protein, family 5 AOQ80_23000 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOQ80_23015 ENOG4108JQ7 (ABC) transporter AOQ80_23020 ENOG4108HRK Histidine kinase AOQ80_23025 ENOG4105DY9 regulatoR AOQ80_23040 ENOG41067S9 phage shock protein C, PspC AOQ80_23045 ENOG4108JCI Transcriptional regulator AOQ80_23055 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AOQ80_23060 ENOG4108Z40 Transcriptional regulator AOQ80_23065 ENOG4105RHA ABC transporter, permease AOQ80_23070 ENOG4108IUX (ABC) transporter AOQ80_23075 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AOQ80_23085 ENOG4105E14 MotA TolQ exbB proton channel AOQ80_23090 ENOG4108VXD carboxy-peptidase AOQ80_23100 ENOG4105E33 succinate dehydrogenase AOQ80_23110 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AOQ80_23125 ENOG4105K63 Thioredoxin AOQ80_23130 ENOG4105C10 Electron transfer flavoprotein AOQ80_23135 ENOG4105BZJ Electron transfer flavoprotein AOQ80_23140 ENOG41060WC Enoyl-CoA hydratase AOQ80_23145 ENOG4107Z3H Transcriptional regulator, TetR family AOQ80_23150 ENOG4105CEY Amp-dependent synthetase and ligase AOQ80_23160 ENOG4105J76 Periplasmic binding protein AOQ80_23165 ENOG4105S6R Iron-hydroxamate transporter permease subunit AOQ80_23210 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOQ80_23225 ENOG4105DR4 Methyltransferase AOQ80_23240 ENOG4105KFN sortase, SrtB family AOQ80_23245 ENOG4105E0A ABC, transporter AOQ80_23260 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AOQ80_23270 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AOQ80_23280 ENOG4105FE9 pseudouridine synthase AOQ80_23295 ENOG4105DCG PHP domain protein AOQ80_23330 ENOG4105C5S asparaginyl-tRNA synthetase AOQ80_23335 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AOQ80_23345 ENOG4108RWN rrna methyltransferase AOQ80_23380 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOQ80_23385 ENOG4105CW7 secretion protein, HlyD family AOQ80_23390 ENOG4108JGH Tetr family transcriptional regulator AOQ80_23395 ENOG4105CN9 Peptidase m42 family protein AOQ80_23415 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AOQ80_23420 ENOG4105C22 threonyL-tRNA synthetase AOQ80_23425 ENOG4108TDW sporulation protein YtxC AOQ80_23445 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AOQ80_23450 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AOQ80_23455 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AOQ80_23465 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AOQ80_23470 ENOG4105C2M dna polymerase I AOQ80_23475 ENOG4105BZU Histidine kinase AOQ80_23480 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOQ80_23500 ENOG4108HMX isocitrate dehydrogenase (NADP) AOQ80_23505 ENOG4105BZN citrate synthase AOQ80_23520 ENOG4108REF Sporulation integral membrane protein ytvi AOQ80_23525 ENOG4105FS0 cytoplasmic membrane protein AOQ80_23550 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AOQ80_23555 ENOG4105C6K Malic enzyme AOQ80_23560 ENOG4105C0B DNA polymerase III (alpha subunit) AOQ80_23565 ENOG4105VV2 AOQ80_23575 ENOG4105SFS phosphoesterase RecJ domain protein AOQ80_23610 ENOG4105DC7 peptidase M24 AOQ80_23645 ENOG4105Z7P Acetyltransferase (GNAT) family AOQ80_23650 ENOG41082W1 Cupin 2, conserved barrel domain protein AOQ80_23660 ENOG4105VZ8 Transcriptional regulator AOQ80_23680 ENOG4107YZX Universal stress protein AOQ80_23720 ENOG4108JYZ YitT family AOQ80_23740 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AOQ80_23750 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AOQ80_23755 ENOG4105KBJ sporulation protein ytfj AOQ80_23770 ENOG4105EFZ amidohydrolase AOQ80_23780 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AOQ80_23805 ENOG4106KR7 LysR family Transcriptional regulator AOQ80_23825 ENOG4105C28 cystathionine AOQ80_23845 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AOQ80_23855 ENOG4105EMN RNA polymerase sigma factor AOQ80_23870 ENOG4105F1V Acetoin utilization protein AOQ80_23875 ENOG4105W87 Cbs domain AOQ80_23880 ENOG4105DGU Histone deacetylase AOQ80_23890 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOQ80_23900 ENOG4107SNB ankyrin repeat protein YahD AOQ80_23905 ENOG4105EP9 oxidoreductase AOQ80_23935 ENOG4105ETE Transcriptional regulator (LacI family AOQ80_23960 ENOG4105C88 aminopeptidase AOQ80_24005 ENOG4108VDD TRNA binding domain protein AOQ80_24035 ENOG4105C8F Beta-lactamase domain protein AOQ80_24050 ENOG4108V15 phosphotransferase enzyme family AOQ80_24055 ENOG4108IUM Glycogen debranching enzyme AOQ80_24070 ENOG4107QSE Dipeptidase AOQ80_24075 ENOG4107QSE Dipeptidase AOQ80_24080 ENOG4105YW5 deoR family transcriptional regulator AOQ80_24095 ENOG4105CBX hi0933 family AOQ80_24130 ENOG4108VJ1 Transcriptional regulator (CarD family AOQ80_24135 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AOQ80_24140 ENOG4105CSC Glucose uptake protein AOQ80_24155 ENOG4108ZAF Molybdopterin AOQ80_24160 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AOQ80_24165 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOQ80_24175 ENOG4105D06 uba thif-type nad fad binding protein AOQ80_24200 ENOG41085GJ domain protein AOQ80_24210 ENOG4105DWV Homoserine O-trans-acetylase AOQ80_24220 ENOG4108B31 Spore germination protein AOQ80_24255 ENOG410605W Major Facilitator AOQ80_24260 ENOG4107S91 Sodium hydrogen exchanger AOQ80_24265 ENOG4105NCW Trka-c domain protein AOQ80_24280 ENOG4105C19 ABC transporter AOQ80_24300 ENOG4105N5T Radical SAM Protein AOQ80_24310 ENOG4105DA5 (ABC) transporter AOQ80_24340 ENOG4105E8V Alpha Beta Hydrolase Fold protein AOQ80_24345 ENOG4108Z0R Transferase AOQ80_24350 ENOG4105YVM Phosphoesterase, PA-phosphatase related AOQ80_24355 ENOG4105BZF Glycosyl transferase (Group 1 AOQ80_24365 ENOG4108RIR Molybdenum cofactor biosynthesis protein AOQ80_24420 ENOG4105EGD dinuclear metal center protein, YbgI family AOQ80_24425 ENOG4105BZU Histidine kinase AOQ80_24430 ENOG4105BZU Histidine kinase AOQ80_24435 ENOG4107S9D Alpha beta hydrolase AOQ80_24455 ENOG4105D2X ABC transporter substrate-binding protein AOQ80_24465 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AOQ80_24520 ENOG4108V2W Carbonate dehydratase AOQ80_24525 ENOG4105C4M (Ubiquinol oxidase) subunit I AOQ80_24530 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AOQ80_24575 ENOG41087YS Phage shock protein A AOQ80_24610 ENOG4105BZU Histidine kinase AOQ80_24615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOQ80_24640 ENOG4108UGV hypoxanthine phosphoribosyltransferase AOQ80_24645 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AOQ80_24680 ENOG4107ZTW SNARE associated Golgi AOQ80_24695 ENOG4105C19 ABC transporter AOQ80_24700 ENOG41086D8 Transcriptional regulator AOQ80_24750 ENOG4105C6Z Gluconate AOQ80_24755 ENOG4105FDP GntR family transcriptional regulator AOQ80_24775 ENOG41069H0 dihydroorotase EC 3.5.2.3 AOQ80_24805 ENOG4105DTQ mandelate racemase muconate lactonizing AOQ80_24815 ENOG4108IPT Naphthoate synthase AOQ80_24820 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AOQ80_24825 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AOQ80_24830 ENOG4105E4F Isochorismate synthase AOQ80_24835 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AOQ80_24845 ENOG4105VEQ Cold shock protein AOQ80_24870 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AOQ80_24880 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AOQ80_24890 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOQ80_24985 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AOQ80_25020 ENOG4105KT7 mgtC SapB transporter AOQ80_25025 ENOG4107PBV potassium channel AOQ80_25035 ENOG4107QYV phosphohexose isomerase AOQ80_25045 ENOG4105WG9 Conserved Protein AOQ80_25055 ENOG4105CHM Aminotransferase AOQ80_25060 ENOG4108ZB6 transcriptional regulator AsnC family AOQ80_25065 ENOG4105C5I Dehydrogenase AOQ80_25070 ENOG4108MUZ hydrolase AOQ80_25080 ENOG4105C87 Aminotransferase class I and II AOQ80_25095 ENOG4105Y38 Kinase-associated protein B AOQ80_25105 ENOG4107R3E Citrate transporter AOQ80_25120 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AOQ80_25125 ENOG4105KA0 thioesterase Superfamily protein AOQ80_25145 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AOQ80_25165 ENOG41069ER domain protein AOQ80_25180 ENOG4105CEP NADH dehydrogenase AOQ80_25210 ENOG4105EWC Purine nucleoside phosphorylase AOQ80_25230 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AOQ80_25255 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOQ80_25260 ENOG4105C4B ABC transporter, permease AOQ80_25265 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AOQ80_25310 ENOG41083MR nifu domain-containing protein AOQ80_25325 ENOG4108W5N phosphatidylglycerophosphatase a AOQ80_25340 ENOG4105DYS nad(p)h dehydrogenase (quinone) AOQ80_25345 ENOG4105D4U had-superfamily hydrolase, subfamily iia AOQ80_25360 ENOG4105CBT Fructose-1,6-bisphosphatase AOQ80_25380 ENOG4105MMD transcriptional regulator AOQ80_25385 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AOQ80_25390 ENOG4107TXC Transcriptional regulator AOQ80_25395 ENOG41090T1 Membrane AOQ80_25420 ENOG4105FAA peptidase M23 AOQ80_25430 ENOG4105KZD Domain of unknown function (DUF1805) AOQ80_25435 ENOG4107R8B 5'-nucleotidase AOQ80_25460 ENOG4105DIW FeS assembly protein SUFB AOQ80_25465 ENOG4108UNV SUF system FeS assembly protein, NifU family AOQ80_25470 ENOG4105C9B Cysteine desulfurase AOQ80_25475 ENOG4105JRK feS assembly protein SufD AOQ80_25480 ENOG4105C3K feS assembly ATPase SufC AOQ80_25485 ENOG4105D01 (LipO)protein AOQ80_25490 ENOG4105D01 (LipO)protein AOQ80_25495 ENOG4108UMI ABC transporter, permease AOQ80_25530 ENOG41080E8 Transcriptional regulator, Spx MgsR family AOQ80_25580 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOQ80_25605 ENOG4108W8B Beta-lactamase domain protein AOQ80_25610 ENOG4105C1G acyl-Coa dehydrogenase AOQ80_25620 ENOG4105CHU acetyl-coa acetyltransferase AOQ80_25635 ENOG4105DZ1 carboxypeptidase AOQ80_25655 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AOQ80_25675 ENOG4108SUT Major Facilitator Superfamily AOQ80_25680 ENOG4107R7I amino acid AOQ80_25690 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AOQ80_25700 ENOG4107AYK membrAne AOQ80_25735 ENOG4107ZTW SNARE associated Golgi AOQ80_25745 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AOQ80_25750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOQ80_25755 ENOG4105BZU Histidine kinase AOQ80_25765 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AOQ80_25780 ENOG4105VG1 fes assembly suf system protein AOQ80_25785 ENOG4105D4Y metalloprotease AOQ80_25805 ENOG4107S91 Sodium hydrogen exchanger AOQ80_25810 ENOG4105NCW Trka-c domain protein AOQ80_25825 ENOG4108RMU ferritin dps family protein AOQ80_25840 ENOG4108URH decarboxylase AOQ80_25865 ENOG4105D9N nucleoside AOQ80_25870 ENOG4105D9N nucleoside AOQ80_25885 ENOG4108RYK Nad-dependent epimerase dehydratase AOQ80_25900 ENOG4105CV8 reductase AOQ80_25905 ENOG4105F27 Major Facilitator AOQ80_25910 ENOG4105KVH Transcriptional regulator AOQ80_25925 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AOQ80_25930 ENOG4105D4A Cell wall formation (By similarity) AOQ80_25940 ENOG4105C8Q Methyl-accepting chemotaxis AOQ80_25950 ENOG4105WMR Protein CrcB homolog AOQ80_25955 ENOG4105WMR Protein CrcB homolog AOQ80_25970 ENOG4108MK9 spermidine N(1)-acetyltransferase AOQ80_25975 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AOQ80_25990 ENOG4108IPW abc transporter atp-binding protein AOQ80_25995 ENOG4105CM4 permease protein AOQ80_26020 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AOQ80_26030 ENOG4105XZU Preprotein translocase, subunit SecG AOQ80_26035 ENOG41067MG lrgb family AOQ80_26135 ENOG4105EFC phage portal protein HK97 family AOQ80_26160 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AOQ80_26170 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AOQ80_26175 ENOG4105CP7 Triose-phosphate isomerase AOQ80_26200 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOQ80_26220 ENOG41090VF Stage v sporulation protein ac AOQ80_26225 ENOG4105CZ3 stage V sporulation protein ad AOQ80_26240 ENOG4105H67 Protein of unknown function (DUF421) AOQ80_26245 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AOQ80_26250 ENOG4105KRI phosphocarrier protein (HPr AOQ80_26260 ENOG4105CHW UPF0052 protein AOQ80_26270 ENOG4108Z4K mutator MutT protein AOQ80_26280 ENOG4105C3M thioredoxin reductase AOQ80_26290 ENOG4108S4C acetyltransferase AOQ80_26310 ENOG41086DT Membrane protein of unknown function AOQ80_26320 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOQ80_26325 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AOQ80_26330 ENOG4105D7V transposase AOQ80_26345 ENOG4107TXC Transcriptional regulator AOQ80_26370 ENOG4105HMI Membrane AOQ80_26375 ENOG4105DUM transcriptional regulator, lysR family AOQ80_26385 ENOG4108WS4 fmn reductase AOQ80_26400 ENOG4105BZ1 (ABC) transporter AOQ80_26410 ENOG4105CN1 protease AOQ80_26415 ENOG4105CRP Part of the ABC transporter FtsEX involved in AOQ80_26420 ENOG4105CAK Cell division ATP-binding protein ftsE AOQ80_26435 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AOQ80_26440 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AOQ80_26445 ENOG4105MS2 ribosomal subunit Interface protein AOQ80_26450 ENOG4105VEQ Cold shock protein AOQ80_26455 ENOG41081UC Inherit from COG: Competence protein AOQ80_26470 ENOG4105KVH Transcriptional regulator AOQ80_26485 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AOQ80_26490 ENOG4108KGH TRANSCRIPTIONal AOQ80_26495 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AOQ80_26500 ENOG4105C6Y Udp-glucose 6-dehydrogenase AOQ80_26505 ENOG4105ESV Glycosyl transferase, family 4 AOQ80_26515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOQ80_26530 ENOG410901P UPF0249 protein AOQ80_26535 ENOG4105F8D glycoside hydrolase family 4 AOQ80_26540 ENOG4105VCP PTS System AOQ80_26545 ENOG4105CK1 PTS System AOQ80_26555 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AOQ80_26560 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AOQ80_26565 ENOG4105VCP PTS System AOQ80_26575 ENOG4105VZJ PTS System AOQ80_26590 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AOQ80_26595 ENOG4105ECB domain protein AOQ80_26600 ENOG4107RSM transcriptional regulator AOQ80_26645 ENOG4105DAA L-lactate AOQ80_26655 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AOQ80_26665 ENOG4105E0M Sulfatase AOQ80_26700 ENOG4105C94 Transporter AOQ80_26705 ENOG41069ER domain protein AOQ80_26730 ENOG4105KBK Zinc finger, swim domain protein AOQ80_26735 ENOG4105C0D helicase AOQ80_26765 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOQ80_26775 ENOG4107RBB ABC transporter, permease AOQ80_26780 ENOG4105C19 ABC transporter AOQ80_26800 ENOG4105CXY transporter AOQ80_26815 ENOG4105BZU Histidine kinase AOQ80_26820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOQ80_26825 ENOG4105CMR udp-glucose 4-epimerase AOQ80_26840 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AOQ80_26845 ENOG4105EY8 ABC transporter AOQ80_26900 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AOQ80_26915 ENOG4105FRN stage II sporulation protein AOQ80_26930 ENOG4105DY9 regulatoR AOQ80_26935 ENOG4108IUW ABC transporter AOQ80_26955 ENOG4106778 Protein of unknown function (DUF1146) AOQ80_26960 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AOQ80_26965 ENOG4105C8S subunit m AOQ80_26970 ENOG4105D65 subunit l AOQ80_26995 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AOQ80_27000 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AOQ80_27010 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AOQ80_27015 ENOG4105BZU Histidine kinase AOQ80_27065 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AOQ80_27070 ENOG41062M3 atp synthase AOQ80_27100 ENOG4108YZG isomerase AOQ80_27115 ENOG4108VGI doxx family AOQ80_27120 ENOG4107XC4 flavin reductase domain protein, FMN-binding AOQ80_27135 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AOQ80_27145 ENOG4108ZXQ stage ii sporulation protein r AOQ80_27150 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AOQ80_27155 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AOQ80_27170 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AOQ80_27175 ENOG4105CBT Fructose-1,6-bisphosphatase AOQ80_27180 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AOQ80_27215 ENOG4105C1G acyl-Coa dehydrogenase AOQ80_27220 ENOG4105C1G acyl-Coa dehydrogenase AOQ80_27225 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AOQ80_27235 ENOG4105DF6 Fe-S oxidoreductase AOQ80_27250 ENOG4105BZU Histidine kinase AOQ80_27270 ENOG4105BZU Histidine kinase AOQ80_27275 ENOG4105KCT ABC transporter AOQ80_27280 ENOG4108M15 ABC transporter AOQ80_27285 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AOQ80_27305 ENOG4105IIU Aminopeptidase AOQ80_27325 ENOG4105EMN RNA polymerase sigma factor AOQ80_27335 ENOG410684U Domain of unknown function (DUF1934) AOQ80_27360 ENOG4105CYW agmatinase AOQ80_27370 ENOG4105DXB Major Facilitator superfamily AOQ80_27375 ENOG4107SWG transcriptional regulator MERR family AOQ80_27380 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AOQ80_27385 ENOG4105BZ4 penicillin-binding protein AOQ80_27390 ENOG4108XFG YwhD family AOQ80_27395 ENOG4108Z4T Peptidase M50 AOQ80_27400 ENOG41069HH 4-oxalocrotonate tautomerase AOQ80_27405 ENOG4105DCI Phosphohydrolase AOQ80_27410 ENOG4108MES Periplasmic binding protein AOQ80_27415 ENOG4105E0A ABC, transporter AOQ80_27420 ENOG4105EHG Permease protein AOQ80_27425 ENOG4105DQ5 transport system permease protein AOQ80_27430 ENOG4105DQ5 transport system permease protein AOQ80_27440 ENOG4108VCI transcription factor, rsfa family AOQ80_27455 ENOG4108IJ2 phosphate acetyltransferase AOQ80_27470 ENOG4108VKI Cell wall hydrolase AOQ80_27500 ENOG410667J hydrolase AOQ80_27505 ENOG4105VCH membrane AOQ80_27515 ENOG4108TU7 Inherit from COG: (ABC) transporter AOQ80_27520 ENOG4105CJ1 ABC, transporter AOQ80_27525 ENOG41090WU lipolytic protein G-D-S-L family AOQ80_27540 ENOG4105D6E homoserine dehydrogenase AOQ80_27565 ENOG4108Y4K DNA-binding transcriptional activator AOQ80_27575 ENOG4105WH1 Two component transcriptional regulator luxr family AOQ80_27585 ENOG4105DWF phosphomethylpyrimidine kinase AOQ80_27590 ENOG4105BZU Histidine kinase AOQ80_27595 ENOG4105VCD cytoplasmic protein AOQ80_27600 ENOG4105D22 carbon starvation protein AOQ80_27605 ENOG4105DY9 regulatoR AOQ80_27610 ENOG41079KZ Major Facilitator Superfamily AOQ80_27630 ENOG4105EN6 Membrane AOQ80_27635 ENOG4106YBV Methyl-accepting chemotaxis AOQ80_27645 ENOG4108S4H thioesterase Superfamily protein AOQ80_27655 ENOG4105JEU Glycosyl transferase, family 2 AOQ80_27660 ENOG4105C5H ABC transporter AOQ80_27690 ENOG4105CKK Glycosyl transferase, family 2 AOQ80_27695 ENOG41067SE Tetr family transcriptional regulator AOQ80_27705 ENOG4105E0X reductase AOQ80_27710 ENOG4106F5Q Membrane AOQ80_27725 ENOG4105DY9 regulatoR AOQ80_27730 ENOG4108HRK Histidine kinase AOQ80_27735 ENOG4107RGD Major Facilitator superfamily AOQ80_27750 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOQ80_27760 ENOG4105IW1 AmiS UreI transporter AOQ80_27770 ENOG4105CMR udp-glucose 4-epimerase AOQ80_27775 ENOG4108UT2 hemolysin iii AOQ80_27785 ENOG4105C1J atp-dependent rna helicase AOQ80_27800 ENOG4105DPN Oligoendopeptidase f AOQ80_27820 ENOG4105C0H protease AOQ80_27825 ENOG4105Q2H domain protein AOQ80_27840 ENOG4105BZU Histidine kinase AOQ80_27845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOQ80_27875 ENOG4105CDU Replicative dna helicase AOQ80_27885 ENOG4105BZR domain protein AOQ80_27890 ENOG4108XMW Membrane AOQ80_27900 ENOG4108UUM single-stranded DNA-binding protein AOQ80_27910 ENOG4105C3G gtp-binding protein AOQ80_27915 ENOG4105VDK protein, conserved in bacteria AOQ80_27920 ENOG4105D8X mechanosensitive ion channel AOQ80_27925 ENOG4108ZDA Sporulation protein YyaC AOQ80_27930 ENOG4105FA0 parb-like partition protein AOQ80_27935 ENOG4107QJE Chromosome Partitioning Protein AOQ80_27955 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AOQ80_27965 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins