locus-tag	class	description
KM393_00010	COG0592	DNA-directed DNA polymerase activity
KM393_00015	COG2501	S4 domain
KM393_00025	COG0187	DNA topoisomerase II activity
KM393_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM393_00065	COG0516	GMP reductase activity
KM393_00065	COG0517	IMP dehydrogenase activity
KM393_00070	COG1686	Belongs to the peptidase S11 family
KM393_00100	COG1428	Deoxynucleoside kinase
KM393_00105	COG1428	Deoxynucleoside kinase
KM393_00110	COG1335	isochorismatase
KM393_00115	COG0590	tRNA wobble adenosine to inosine editing
KM393_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KM393_00180	COG1982	Orn Lys Arg decarboxylase major
KM393_00190	COG0470	DNA polymerase III
KM393_00195	COG1774	PSP1 C-terminal conserved region
KM393_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KM393_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KM393_00220	COG2002	toxin-antitoxin pair type II binding
KM393_00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM393_00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM393_00230	COG0084	hydrolase, TatD family'
KM393_00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM393_00250	COG4466	Protein conserved in bacteria
KM393_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KM393_00270	COG0251	oxidation-reduction process
KM393_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KM393_00305	COG2002	toxin-antitoxin pair type II binding
KM393_00310	COG2244	polysaccharide biosynthetic process
KM393_00315	COG3956	TIGRFAM MazG family protein
KM393_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KM393_00340	COG1098	S1 RNA binding domain
KM393_00355	COG2208	phosphoserine phosphatase activity
KM393_00360	COG0037	tRNA processing
KM393_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KM393_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM393_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM393_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KM393_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
KM393_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM393_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KM393_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KM393_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KM393_00420	COG1396	sequence-specific DNA binding
KM393_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM393_00455	COG3880	PFAM UvrB UvrC protein
KM393_00465	COG0542	response to heat
KM393_00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KM393_00480	COG4956	integral membrane protein (PIN domain superfamily)
KM393_00500	COG1045	serine acetyltransferase
KM393_00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM393_00520	COG3688	RNA-binding protein containing a PIN domain
KM393_00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM393_00540	COG0250	Participates in transcription elongation, termination and antitermination
KM393_00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KM393_00565	COG2813	Specifically methylates the guanine in position
KM393_00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KM393_00580	COG1358	cellular component organization or biogenesis
KM393_00650	COG0255	Belongs to the universal ribosomal protein uL29 family
KM393_00710	COG0201	protein transport
KM393_00720	COG0024	Methionine aminopeptidase
KM393_00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KM393_00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM393_00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM393_00795	COG0489	protein tyrosine kinase activity
KM393_00805	COG2194	sulfuric ester hydrolase activity
KM393_00810	COG0726	polysaccharide deacetylase
KM393_00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KM393_00895	COG4856	YbbR-like protein
KM393_00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KM393_00915	COG0596	Alpha beta hydrolase
KM393_00935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KM393_00940	COG1506	peptidase
KM393_00940	COG0823	Involved in the tonB-independent uptake of proteins
KM393_00940	COG4946	Tricorn protease homolog
KM393_00975	COG2011	ABC-type metal ion transport system permease component
KM393_00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM393_00985	COG1464	Belongs to the NlpA lipoprotein family
KM393_00990	COG0604	alcohol dehydrogenase
KM393_01000	COG0277	FAD linked oxidase domain protein
KM393_01005	COG2271	Major facilitator Superfamily
KM393_01015	COG2814	Major facilitator Superfamily
KM393_01030	COG0601	transmembrane transport
KM393_01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM393_01040	COG0444	Belongs to the ABC transporter superfamily
KM393_01045	COG4608	Belongs to the ABC transporter superfamily
KM393_01050	COG4166	transmembrane transport
KM393_01060	COG2207	Transcriptional regulator
KM393_01075	COG4166	transmembrane transport
KM393_01080	COG4166	transmembrane transport
KM393_01085	COG0656	L-ascorbic acid biosynthetic process
KM393_01090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM393_01105	COG4149	molybdate abc transporter
KM393_01115	COG1910	domain protein
KM393_01125	COG0583	DNA-binding transcription factor activity
KM393_01130	COG0697	spore germination
KM393_01145	COG0204	Acyl-transferase
KM393_01155	COG1609	Transcriptional regulator
KM393_01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM393_01175	COG0084	hydrolase, TatD family'
KM393_01180	COG5298	Protein conserved in bacteria
KM393_01205	COG0488	(ABC) transporter
KM393_01220	COG0747	negative chemotaxis
KM393_01225	COG0601	transmembrane transport
KM393_01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM393_01235	COG0444	Belongs to the ABC transporter superfamily
KM393_01240	COG4608	Belongs to the ABC transporter superfamily
KM393_01285	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KM393_01290	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM393_01300	COG2814	Major facilitator Superfamily
KM393_01310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KM393_01320	COG4294	response to UV
KM393_01325	COG0705	Rhomboid family
KM393_01325	COG0457	Tetratricopeptide repeat
KM393_01335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KM393_01340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM393_01345	COG0864	Transcriptional regulator
KM393_01350	COG2337	Toxic component of a toxin-antitoxin (TA) module
KM393_01355	COG2183	response to ionizing radiation
KM393_01450	COG0802	atpase or kinase
KM393_01455	COG1214	PFAM Peptidase M22, glycoprotease
KM393_01460	COG0456	acetyltransferase
KM393_01470	COG0488	(ABC) transporter
KM393_01485	COG1266	CAAX protease self-immunity
KM393_01505	COG2252	PERMEase
KM393_01515	COG5002	protein histidine kinase activity
KM393_01545	COG2226	methyltransferase
KM393_01585	COG1968	undecaprenyl-diphosphatase activity
KM393_01600	COG2205	protein histidine kinase activity
KM393_01605	COG0745	RESPONSE REGULATOR receiver
KM393_01625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KM393_01630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KM393_01635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KM393_01645	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KM393_01660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KM393_01670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KM393_01680	COG0151	Belongs to the GarS family
KM393_01705	COG0210	DNA helicase
KM393_01715	COG4851	CamS sex pheromone cAM373 precursor
KM393_01735	COG1335	isochorismatase
KM393_01740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM393_01745	COG2011	ABC-type metal ion transport system permease component
KM393_01750	COG1464	Belongs to the NlpA lipoprotein family
KM393_01770	COG1846	Transcriptional regulator
KM393_01795	COG1597	lipid kinase activity
KM393_01800	COG0546	phosphoglycolate phosphatase activity
KM393_01805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM393_01815	COG1012	belongs to the aldehyde dehydrogenase family
KM393_01820	COG2076	Multidrug Resistance protein
KM393_01825	COG2309	aminopeptidase activity
KM393_01840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM393_01845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM393_01850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM393_01860	COG4807	Protein conserved in bacteria
KM393_01885	COG1757	Na H antiporter
KM393_01890	COG1473	amidohydrolase
KM393_01905	COG0450	alkyl hydroperoxide reductase
KM393_01925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM393_01930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM393_01935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM393_01950	COG0166	Belongs to the GPI family
KM393_01985	COG5002	protein histidine kinase activity
KM393_02005	COG3541	Predicted nucleotidyltransferase
KM393_02010	COG2814	Major facilitator Superfamily
KM393_02015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM393_02015	COG0723	plastoquinol--plastocyanin reductase activity
KM393_02025	COG0765	amino acid transport
KM393_02030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM393_02040	COG0840	transmembrane signaling receptor activity
KM393_02045	COG0840	transmembrane signaling receptor activity
KM393_02050	COG0366	Alpha amylase catalytic
KM393_02055	COG2190	(PTS) system
KM393_02055	COG1263	PTS System
KM393_02055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM393_02085	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KM393_02100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM393_02110	COG1116	anion transmembrane transporter activity
KM393_02115	COG0488	(ABC) transporter
KM393_02160	COG2270	Major facilitator Superfamily
KM393_02175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM393_02190	COG2310	stress, protein
KM393_02195	COG2310	stress, protein
KM393_02200	COG2310	stress, protein
KM393_02205	COG0861	Integral membrane protein TerC family
KM393_02215	COG3853	Toxic anion resistance protein (TelA)
KM393_02230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KM393_02240	COG1295	ribonuclease BN
KM393_02245	COG2217	Heavy metal translocating P-type atpase
KM393_02250	COG0697	spore germination
KM393_02270	COG0586	Pfam SNARE associated Golgi protein
KM393_02285	COG3871	stress protein (general stress protein 26)
KM393_02290	COG0387	Pfam Sodium calcium exchanger
KM393_02300	COG0535	radical SAM domain protein
KM393_02325	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM393_02330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM393_02335	COG0582	viral genome integration into host DNA
KM393_02345	COG1396	sequence-specific DNA binding
KM393_02360	COG1396	sequence-specific DNA binding
KM393_02395	COG1484	DNA-dependent DNA replication
KM393_02625	COG0101	tRNA pseudouridine synthase activity
KM393_02635	COG3829	transcription factor binding
KM393_02645	COG0833	amino acid
KM393_02650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM393_02680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM393_02680	COG1263	PTS System
KM393_02685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM393_02700	COG0463	Glycosyl transferase, family 2
KM393_02715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM393_02715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KM393_02735	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KM393_02755	COG1228	amidohydrolase
KM393_02760	COG1090	epimerase
KM393_02790	COG1988	membrane-bound metal-dependent
KM393_02795	COG1194	a g-specific adenine glycosylase
KM393_02820	COG1132	(ABC) transporter
KM393_02825	COG4129	membrane
KM393_02830	COG0070	glutamate synthase
KM393_02830	COG0069	glutamate synthase activity
KM393_02830	COG0067	glutamate synthase
KM393_02840	COG4555	ABC transporter
KM393_02860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KM393_02865	COG0735	belongs to the Fur family
KM393_02980	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KM393_02985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KM393_02995	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KM393_03005	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KM393_03015	COG2766	serine protein kinase
KM393_03035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM393_03045	COG1585	Membrane protein implicated in regulation of membrane protease activity
KM393_03050	COG2268	Band 7 protein
KM393_03060	COG3290	protein histidine kinase activity
KM393_03065	COG4565	transcriptional regulatory protein
KM393_03070	COG2851	Citrate transporter
KM393_03090	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM393_03095	COG3842	ATPase activity
KM393_03100	COG1175	transmembrane transport
KM393_03105	COG0395	ABC-type sugar transport system, permease component
KM393_03115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KM393_03120	COG0745	RESPONSE REGULATOR receiver
KM393_03125	COG5002	protein histidine kinase activity
KM393_03135	COG4990	cell redox homeostasis
KM393_03145	COG3290	protein histidine kinase activity
KM393_03150	COG4565	transcriptional regulatory protein
KM393_03155	COG3493	citrate carrier protein
KM393_03160	COG0281	malic enzyme
KM393_03175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM393_03185	COG5002	protein histidine kinase activity
KM393_03190	COG0745	RESPONSE REGULATOR receiver
KM393_03195	COG0456	acetyltransferase
KM393_03195	COG0454	-acetyltransferase
KM393_03200	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM393_03205	COG3383	formate dehydrogenase (NAD+) activity
KM393_03210	COG2427	Protein of unknown function (DUF1641)
KM393_03225	COG0531	amino acid
KM393_03230	COG0640	Transcriptional regulator
KM393_03235	COG2217	Heavy metal translocating P-type atpase
KM393_03240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KM393_03255	COG3227	Zinc metalloprotease (Elastase)
KM393_03275	COG2720	vancomycin resistance protein
KM393_03280	COG1316	TRANSCRIPTIONal
KM393_03285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM393_03290	COG0346	lactoylglutathione lyase activity
KM393_03295	COG1253	flavin adenine dinucleotide binding
KM393_03300	COG1027	Aspartate ammonia-lyase
KM393_03305	COG1620	l-lactate permease
KM393_03320	COG3104	oligopeptide transport
KM393_03325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM393_03330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM393_03335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM393_03345	COG2226	methyltransferase
KM393_03350	COG0156	8-amino-7-oxononanoate synthase activity
KM393_03355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM393_03365	COG4548	von Willebrand factor, type A
KM393_03370	COG0714	Associated with various cellular activities
KM393_03375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM393_03395	COG0531	amino acid
KM393_03400	COG2188	Transcriptional regulator
KM393_03405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM393_03405	COG1263	PTS System
KM393_03410	COG0366	Alpha amylase catalytic
KM393_03425	COG0697	spore germination
KM393_03435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM393_03440	COG1115	amino acid carrier protein
KM393_03445	COG1126	abc transporter atp-binding protein
KM393_03450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM393_03455	COG0765	amino acid transport
KM393_03460	COG0765	amino acid transport
KM393_03465	COG0833	amino acid
KM393_03490	COG2378	regulation of single-species biofilm formation
KM393_03495	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KM393_03500	COG5002	protein histidine kinase activity
KM393_03515	COG0659	secondary active sulfate transmembrane transporter activity
KM393_03540	COG0601	transmembrane transport
KM393_03545	COG4608	Belongs to the ABC transporter superfamily
KM393_03555	COG2271	Major facilitator Superfamily
KM393_03560	COG1846	Transcriptional regulator
KM393_03570	COG1609	Transcriptional regulator
KM393_03575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM393_03590	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM393_03595	COG1879	ABC-type sugar transport system periplasmic component
KM393_03620	COG1063	alcohol dehydrogenase
KM393_03635	COG3568	Endonuclease Exonuclease Phosphatase
KM393_03660	COG1968	undecaprenyl-diphosphatase activity
KM393_03665	COG0840	transmembrane signaling receptor activity
KM393_03670	COG3584	3D domain protein
KM393_03670	COG1388	LysM domain
KM393_03675	COG1476	TRANSCRIPTIONal
KM393_03690	COG3104	oligopeptide transport
KM393_03695	COG1114	Component of the transport system for branched-chain amino acids
KM393_03710	COG1113	amino acid transport
KM393_03715	COG2252	PERMEase
KM393_03740	COG0475	glutathione-regulated potassium exporter activity
KM393_03740	COG0569	domain protein
KM393_03755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KM393_03760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KM393_03765	COG0833	amino acid
KM393_03770	COG4990	cell redox homeostasis
KM393_03785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM393_03790	COG0697	spore germination
KM393_03795	COG0531	amino acid
KM393_03805	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM393_03810	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM393_03815	COG1918	ferrous iron import across plasma membrane
KM393_03815	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM393_03820	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM393_03825	COG0573	inorganic phosphate transmembrane transporter activity
KM393_03830	COG0581	inorganic phosphate transmembrane transporter activity
KM393_03840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM393_03960	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KM393_03980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM393_03985	COG1116	anion transmembrane transporter activity
KM393_03990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM393_03995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM393_04000	COG0352	thiamine-phosphate diphosphorylase activity
KM393_04005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM393_04010	COG2104	thiamine diphosphate biosynthetic process
KM393_04020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM393_04025	COG0351	phosphomethylpyrimidine kinase
KM393_04065	COG2205	protein histidine kinase activity
KM393_04070	COG2814	Major facilitator Superfamily
KM393_04075	COG1846	Transcriptional regulator
KM393_04090	COG2252	PERMEase
KM393_04095	COG1028	Short-chain dehydrogenase reductase Sdr
KM393_04110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM393_04115	COG1621	beta-fructofuranosidase activity
KM393_04120	COG1263	PTS System
KM393_04120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM393_04125	COG1609	Transcriptional regulator
KM393_04135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM393_04140	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KM393_04175	COG0778	Nitroreductase
KM393_04180	COG2719	SpoVR family
KM393_04205	COG0446	pyridine nucleotide-disulphide oxidoreductase
KM393_04210	COG1937	Protein conserved in bacteria
KM393_04215	COG0425	Belongs to the sulfur carrier protein TusA family
KM393_04215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM393_04220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM393_04220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM393_04225	COG0425	Belongs to the sulfur carrier protein TusA family
KM393_04230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM393_04240	COG2210	Belongs to the sulfur carrier protein TusA family
KM393_04245	COG0730	response to heat
KM393_04255	COG1316	TRANSCRIPTIONal
KM393_04260	COG0604	alcohol dehydrogenase
KM393_04265	COG1283	sodium-dependent phosphate transmembrane transporter activity
KM393_04280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM393_04280	COG3711	transcriptional antiterminator
KM393_04285	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM393_04290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM393_04310	COG1388	LysM domain
KM393_04310	COG3584	3D domain protein
KM393_04315	COG0577	efflux transmembrane transporter activity
KM393_04320	COG1136	(ABC) transporter
KM393_04330	COG5522	Integral membrane protein (intg_mem_TP0381)
KM393_04345	COG1114	Component of the transport system for branched-chain amino acids
KM393_04350	COG3546	catalase activity
KM393_04385	COG0586	Pfam SNARE associated Golgi protein
KM393_04420	COG0531	amino acid
KM393_04425	COG0475	glutathione-regulated potassium exporter activity
KM393_04435	COG1737	Transcriptional regulator
KM393_04445	COG1263	PTS System
KM393_04445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM393_04455	COG2259	Doxx family
KM393_04470	COG0697	spore germination
KM393_04475	COG1522	sequence-specific DNA binding
KM393_04490	COG2076	Multidrug Resistance protein
KM393_04495	COG1309	transcriptional regulator
KM393_04500	COG2814	Major facilitator Superfamily
KM393_04505	COG1733	regulation of RNA biosynthetic process
KM393_04515	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM393_04520	COG4533	DNA binding
KM393_04525	COG2211	Major facilitator Superfamily
KM393_04535	COG0693	protein deglycase activity
KM393_04540	COG0693	protein deglycase activity
KM393_04540	COG0753	catalase activity
KM393_04550	COG0531	amino acid
KM393_04555	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KM393_04565	COG1012	belongs to the aldehyde dehydrogenase family
KM393_04570	COG1132	(ABC) transporter
KM393_04580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM393_04585	COG0765	amino acid transport
KM393_04590	COG1126	abc transporter atp-binding protein
KM393_04605	COG0189	ligase activity
KM393_04635	COG0028	Belongs to the TPP enzyme family
KM393_04640	COG3527	Alpha-acetolactate decarboxylase
KM393_04655	COG0561	phosphatase activity
KM393_04670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM393_04685	COG0659	secondary active sulfate transmembrane transporter activity
KM393_04705	COG0653	protein targeting
KM393_04710	COG2244	polysaccharide biosynthetic process
KM393_04720	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM393_04725	COG4196	transglutaminase domain protein
KM393_04740	COG1696	Membrane protein involved in D-alanine export
KM393_04755	COG1024	Enoyl-CoA hydratase
KM393_04775	COG1363	Peptidase, m42
KM393_04795	COG3938	Belongs to the proline racemase family
KM393_04835	COG0601	transmembrane transport
KM393_04840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM393_04850	COG4608	Belongs to the ABC transporter superfamily
KM393_04855	COG0322	excinuclease ABC activity
KM393_04885	COG0477	Major facilitator Superfamily
KM393_04890	COG3290	protein histidine kinase activity
KM393_04895	COG4565	transcriptional regulatory protein
KM393_04900	COG3181	Tripartite tricarboxylate transporter family receptor
KM393_04930	COG0789	Transcriptional regulator
KM393_04930	COG4978	Transcriptional regulator
KM393_04945	COG0305	Participates in initiation and elongation during chromosome replication
KM393_04985	COG0477	Major facilitator Superfamily
KM393_05030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM393_05030	COG3320	Male sterility
KM393_05035	COG1309	transcriptional regulator
KM393_05055	COG1183	phosphatidylcholine synthase activity
KM393_05075	COG2376	Dihydroxyacetone kinase
KM393_05085	COG2376	Dihydroxyacetone kinase
KM393_05090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM393_05095	COG1959	2 iron, 2 sulfur cluster binding
KM393_05125	COG2770	Histidine kinase
KM393_05125	COG3437	response regulator, receiver
KM393_05175	COG3237	CsbD-like
KM393_05200	COG1191	sigma factor activity
KM393_05210	COG2208	phosphoserine phosphatase activity
KM393_05215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM393_05220	COG0784	Response regulator, receiver
KM393_05220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM393_05220	COG2198	Histidine kinase
KM393_05220	COG2205	protein histidine kinase activity
KM393_05275	COG0420	3'-5' exonuclease activity
KM393_05280	COG4717	serine-type aminopeptidase activity
KM393_05300	COG1309	transcriptional regulator
KM393_05305	COG2814	Major facilitator Superfamily
KM393_05310	COG0346	lactoylglutathione lyase activity
KM393_05320	COG0346	lactoylglutathione lyase activity
KM393_05325	COG0457	Tetratricopeptide repeat
KM393_05330	COG2267	carboxylic ester hydrolase activity
KM393_05350	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM393_05355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KM393_05365	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KM393_05405	COG0477	Major facilitator Superfamily
KM393_05410	COG0477	Major facilitator Superfamily
KM393_05420	COG3973	AAA domain
KM393_05425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM393_05445	COG4980	gas vesicle protein
KM393_05450	COG0537	adenosine 5'-monophosphoramidase activity
KM393_05455	COG1131	(ABC) transporter
KM393_05460	COG4473	ABC transporter
KM393_05475	COG1309	transcriptional regulator
KM393_05485	COG3402	PFAM membrane-flanked domain
KM393_05535	COG3402	PFAM membrane-flanked domain
KM393_05540	COG3428	Bacterial PH domain
KM393_05545	COG2329	Antibiotic biosynthesis monooxygenase
KM393_05550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM393_05555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KM393_05560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM393_05565	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM393_05600	COG1309	transcriptional regulator
KM393_05605	COG1511	domain protein
KM393_05630	COG1609	Transcriptional regulator
KM393_05640	COG1234	tRNA 3'-trailer cleavage
KM393_05645	COG0095	Lipoate-protein ligase
KM393_05655	COG0318	PFAM AMP-dependent synthetase and ligase
KM393_05685	COG3209	COG3209 Rhs family protein
KM393_05725	COG1078	dGTPase activity
KM393_05735	COG1595	DNA-templated transcription, initiation
KM393_05740	COG2207	Transcriptional regulator
KM393_05740	COG3708	Transcriptional regulator
KM393_05755	COG2205	protein histidine kinase activity
KM393_05760	COG0745	RESPONSE REGULATOR receiver
KM393_05790	COG0501	Belongs to the peptidase M48B family
KM393_05795	COG0840	transmembrane signaling receptor activity
KM393_05800	COG0697	spore germination
KM393_05820	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KM393_05825	COG2224	Isocitrate lyase
KM393_05850	COG4903	ComK protein
KM393_05855	COG0398	Pfam SNARE associated Golgi protein
KM393_05865	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KM393_05870	COG1074	ATP-dependent DNA helicase activity
KM393_05915	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM393_05940	COG0367	asparagine synthase
KM393_05945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM393_05950	COG0753	catalase activity
KM393_05955	COG0004	ammonium transporteR
KM393_05975	COG2996	Protein conserved in bacteria
KM393_05985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM393_05995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM393_06010	COG0561	phosphatase activity
KM393_06020	COG0542	response to heat
KM393_06030	COG2267	carboxylic ester hydrolase activity
KM393_06045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM393_06050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KM393_06055	COG5504	Zn-dependent protease
KM393_06065	COG0180	Tryptophanyl-tRNA synthetase
KM393_06075	COG4166	transmembrane transport
KM393_06080	COG0601	transmembrane transport
KM393_06085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM393_06090	COG0444	Belongs to the ABC transporter superfamily
KM393_06095	COG4608	Belongs to the ABC transporter superfamily
KM393_06100	COG0534	Mate efflux family protein
KM393_06105	COG4166	transmembrane transport
KM393_06120	COG0861	Integral membrane protein TerC family
KM393_06125	COG4862	establishment of competence for transformation
KM393_06130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM393_06140	COG1164	Oligoendopeptidase f
KM393_06150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM393_06155	COG2346	COG2346, Truncated hemoglobins
KM393_06160	COG4116	CYTH
KM393_06170	COG2357	RelA SpoT domain protein
KM393_06180	COG0564	pseudouridine synthase activity
KM393_06200	COG1216	Glycosyl transferase, family 2
KM393_06200	COG0463	Glycosyl transferase, family 2
KM393_06220	COG0463	Glycosyl transferase, family 2
KM393_06220	COG0457	Tetratricopeptide repeat
KM393_06240	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KM393_06255	COG1091	dTDP-4-dehydrorhamnose reductase activity
KM393_06300	COG2153	protein acetylation
KM393_06310	COG2382	esterase
KM393_06325	COG5492	domain, Protein
KM393_06330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM393_06340	COG0512	Glutamine amidotransferase of anthranilate synthase
KM393_06340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KM393_06375	COG1620	l-lactate permease
KM393_06380	COG5634	Uncharacterized conserved protein (DUF2278)
KM393_06435	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM393_06445	COG1476	TRANSCRIPTIONal
KM393_06505	COG2226	methyltransferase
KM393_06515	COG1686	Belongs to the peptidase S11 family
KM393_06520	COG0681	Belongs to the peptidase S26 family
KM393_06555	COG1012	belongs to the aldehyde dehydrogenase family
KM393_06560	COG3842	ATPase activity
KM393_06565	COG1176	ABC-type spermidine putrescine transport system, permease component I
KM393_06570	COG1177	transmembrane transport
KM393_06575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KM393_06585	COG2409	Drug exporters of the RND superfamily
KM393_06595	COG0564	pseudouridine synthase activity
KM393_06605	COG2340	Cysteine-rich secretory protein family
KM393_06610	COG0247	lactate metabolic process
KM393_06615	COG0277	FAD linked oxidase domain protein
KM393_06620	COG3835	regulator
KM393_06630	COG0745	RESPONSE REGULATOR receiver
KM393_06635	COG5002	protein histidine kinase activity
KM393_06640	COG2186	Transcriptional regulator
KM393_06660	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KM393_06675	COG2116	formate transmembrane transporter activity
KM393_06680	COG0861	Integral membrane protein TerC family
KM393_06685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM393_06695	COG2030	dehydratase
KM393_06715	COG1028	Short-chain dehydrogenase reductase Sdr
KM393_06720	COG3243	poly(R)-hydroxyalkanoic acid synthase
KM393_06725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM393_06730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM393_06745	COG1840	ABC-type Fe3 transport system, periplasmic component
KM393_06775	COG1349	DNA-binding transcription factor activity
KM393_06795	COG2861	carbohydrate metabolic process
KM393_06805	COG3852	Histidine kinase
KM393_06810	COG1846	Transcriptional regulator
KM393_06820	COG2318	DinB family
KM393_06825	COG5002	protein histidine kinase activity
KM393_06835	COG0720	synthase
KM393_06850	COG4873	Protein conserved in bacteria
KM393_06880	COG1780	Probably involved in ribonucleotide reductase function
KM393_06900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KM393_06905	COG1725	Transcriptional regulator
KM393_06910	COG1131	(ABC) transporter
KM393_06920	COG1131	(ABC) transporter
KM393_06925	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM393_06940	COG1522	sequence-specific DNA binding
KM393_06950	COG1335	isochorismatase
KM393_06960	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM393_06965	COG2070	2-Nitropropane dioxygenase
KM393_06970	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM393_06980	COG1696	Membrane protein involved in D-alanine export
KM393_07005	COG0716	FMN binding
KM393_07020	COG3173	Aminoglycoside phosphotransferase
KM393_07040	COG0534	Mate efflux family protein
KM393_07045	COG1968	undecaprenyl-diphosphatase activity
KM393_07060	COG1846	Transcriptional regulator
KM393_07070	COG1301	dicarboxylic acid transport
KM393_07075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM393_07080	COG4709	membrane
KM393_07085	COG3874	Sporulation protein YtfJ
KM393_07110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM393_07115	COG0028	Belongs to the TPP enzyme family
KM393_07120	COG0440	acetolactate synthase activity
KM393_07125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM393_07135	COG0473	3-isopropylmalate dehydrogenase activity
KM393_07160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KM393_07195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM393_07210	COG1183	phosphatidylcholine synthase activity
KM393_07215	COG1368	sulfuric ester hydrolase activity
KM393_07225	COG0019	diaminopimelate decarboxylase activity
KM393_07245	COG0529	Catalyzes the synthesis of activated sulfate
KM393_07250	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM393_07270	COG1648	precorrin-2 dehydrogenase activity
KM393_07275	COG0733	neurotransmitter:sodium symporter activity
KM393_07295	COG1757	Na H antiporter
KM393_07310	COG4758	membrane
KM393_07315	COG4585	Histidine kinase
KM393_07320	COG2197	response regulator
KM393_07330	COG1114	Component of the transport system for branched-chain amino acids
KM393_07340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KM393_07365	COG1017	nitric oxide dioxygenase activity
KM393_07365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KM393_07380	COG0730	response to heat
KM393_07385	COG0306	phosphate transporter
KM393_07390	COG1392	Phosphate transport regulator
KM393_07395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM393_07410	COG3852	Histidine kinase
KM393_07415	COG1801	Protein of unknown function DUF72
KM393_07425	COG0582	viral genome integration into host DNA
KM393_07430	COG5002	protein histidine kinase activity
KM393_07450	COG0392	lysyltransferase activity
KM393_07450	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KM393_07465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM393_07470	COG1686	Belongs to the peptidase S11 family
KM393_07475	COG2715	membrane protein required for spore maturation
KM393_07480	COG0700	Nucleoside recognition
KM393_07485	COG1187	pseudouridine synthase activity
KM393_07495	COG1333	cytochrome c biogenesis protein
KM393_07500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM393_07505	COG0745	RESPONSE REGULATOR receiver
KM393_07510	COG5002	protein histidine kinase activity
KM393_07515	COG2096	Adenosyltransferase
KM393_07530	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KM393_07535	COG1141	Ferredoxin
KM393_07540	COG4955	Helix-turn-helix domain
KM393_07545	COG0514	ATP-dependent DNA helicase (RecQ)
KM393_07550	COG1266	CAAX protease self-immunity
KM393_07570	COG4862	establishment of competence for transformation
KM393_07575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KM393_07595	COG0492	ferredoxin-NADP+ reductase activity
KM393_07670	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM393_07685	COG0142	geranyltranstransferase activity
KM393_07695	COG0142	geranyltranstransferase activity
KM393_07715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM393_07720	COG0457	Tetratricopeptide repeat
KM393_07740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KM393_07750	COG4347	Protein of unknown function (DUF1405)
KM393_07765	COG2738	Putative neutral zinc metallopeptidase
KM393_07775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM393_07780	COG1694	Mazg nucleotide pyrophosphohydrolase
KM393_07795	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM393_07800	COG0438	transferase activity, transferring glycosyl groups
KM393_07835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KM393_07835	COG1199	ATP-dependent helicase activity
KM393_07855	COG3935	DnaD domain protein
KM393_07860	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KM393_07870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM393_07870	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM393_07935	COG0116	Belongs to the methyltransferase superfamily
KM393_07945	COG1199	ATP-dependent helicase activity
KM393_07950	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KM393_07960	COG3173	Aminoglycoside phosphotransferase
KM393_07965	COG0024	Methionine aminopeptidase
KM393_07975	COG2233	PERMEase
KM393_07980	COG2311	Membrane
KM393_07985	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM393_07995	COG0456	acetyltransferase
KM393_08045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM393_08070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KM393_08085	COG1215	transferase activity, transferring glycosyl groups
KM393_08090	COG0438	transferase activity, transferring glycosyl groups
KM393_08105	COG0454	-acetyltransferase
KM393_08125	COG0328	RNA-DNA hybrid ribonuclease activity
KM393_08165	COG1280	lysine exporter protein (LysE YggA)
KM393_08180	COG3162	membrane
KM393_08185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM393_08190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM393_08200	COG0475	glutathione-regulated potassium exporter activity
KM393_08205	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM393_08210	COG0789	Transcriptional regulator
KM393_08210	COG4978	Transcriptional regulator
KM393_08220	COG2323	membrane
KM393_08225	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KM393_08280	COG1923	regulation of RNA biosynthetic process
KM393_08290	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM393_08295	COG1360	Flagellar Motor Protein
KM393_08300	COG2201	protein-glutamate methylesterase activity
KM393_08305	COG0643	Histidine kinase
KM393_08305	COG2198	Histidine kinase
KM393_08310	COG0643	Histidine kinase
KM393_08310	COG2198	Histidine kinase
KM393_08315	COG1776	CheC inhibitor of MCP methylation
KM393_08315	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM393_08330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM393_08350	COG1256	bacterial-type flagellum assembly
KM393_08375	COG1815	bacterial-type flagellum-dependent cell motility
KM393_08380	COG1558	bacterial-type flagellum-dependent cell motility
KM393_08395	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM393_08405	COG1157	protein secretion by the type III secretion system
KM393_08445	COG0835	chemotaxis
KM393_08445	COG0784	Response regulator, receiver
KM393_08455	COG0463	Glycosyl transferase, family 2
KM393_08490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KM393_08495	COG0741	lytic transglycosylase activity
KM393_08510	COG1776	CheC inhibitor of MCP methylation
KM393_08510	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM393_08520	COG1338	Plays a role in the flagellum-specific transport system
KM393_08525	COG1987	bacterial-type flagellum assembly
KM393_08535	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM393_08540	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM393_08545	COG1419	protein localization to endoplasmic reticulum
KM393_08550	COG4786	Flagellar basal body rod
KM393_08555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM393_08580	COG1309	transcriptional regulator
KM393_08600	COG2329	Antibiotic biosynthesis monooxygenase
KM393_08625	COG0583	DNA-binding transcription factor activity
KM393_08630	COG3842	ATPase activity
KM393_08635	COG0725	ABC transporter, periplasmic molybdate-binding protein
KM393_08645	COG1234	tRNA 3'-trailer cleavage
KM393_08670	COG1686	Belongs to the peptidase S11 family
KM393_08680	COG0406	alpha-ribazole phosphatase activity
KM393_08710	COG0367	asparagine synthase
KM393_08740	COG1802	Transcriptional regulator
KM393_08745	COG0697	spore germination
KM393_08750	COG0523	cobalamin synthesis protein
KM393_08755	COG0701	Predicted permease
KM393_08765	COG1216	Glycosyl transferase, family 2
KM393_08765	COG0438	transferase activity, transferring glycosyl groups
KM393_08770	COG1757	Na H antiporter
KM393_08775	COG0114	fumarate hydratase activity
KM393_08800	COG3340	Belongs to the peptidase S51 family
KM393_08820	COG0785	Cytochrome C biogenesis protein
KM393_08850	COG2733	membrane
KM393_08885	COG1131	(ABC) transporter
KM393_08900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM393_08905	COG0528	UMP kinase activity
KM393_08915	COG1027	Aspartate ammonia-lyase
KM393_08920	COG0281	malic enzyme
KM393_08925	COG4191	Histidine kinase
KM393_08930	COG0784	Response regulator, receiver
KM393_08935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM393_08990	COG1051	belongs to the nudix hydrolase family
KM393_08995	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM393_09005	COG2814	Major facilitator Superfamily
KM393_09020	COG1966	Carbon starvation protein
KM393_09035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM393_09045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KM393_09055	COG2223	nitrite transmembrane transporter activity
KM393_09060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM393_09075	COG2244	polysaccharide biosynthetic process
KM393_09080	COG0733	neurotransmitter:sodium symporter activity
KM393_09090	COG5566	PFAM Mor transcription activator
KM393_09095	COG2323	membrane
KM393_09110	COG2084	Dehydrogenase
KM393_09125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM393_09135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM393_09140	COG0028	Belongs to the TPP enzyme family
KM393_09145	COG0440	acetolactate synthase activity
KM393_09150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM393_09160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KM393_09185	COG2814	Major facilitator Superfamily
KM393_09190	COG3384	dioxygenase
KM393_09200	COG3279	Response regulator of the LytR AlgR family
KM393_09205	COG0427	acetyl-CoA hydrolase
KM393_09225	COG1073	alpha beta
KM393_09255	COG0535	radical SAM domain protein
KM393_09260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM393_09280	COG1914	H( )-stimulated, divalent metal cation uptake system
KM393_09295	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM393_09325	COG2390	Transcriptional regulator
KM393_09335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM393_09340	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KM393_09355	COG4224	UPF0291 protein
KM393_09375	COG0006	proline dipeptidase activity
KM393_09380	COG2132	Multicopper oxidase
KM393_09395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM393_09410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM393_09425	COG2372	response to copper ion
KM393_09425	COG1276	copper resistance
KM393_09430	COG4549	nuclear export factor GLE1
KM393_09440	COG0697	spore germination
KM393_09445	COG0583	DNA-binding transcription factor activity
KM393_09450	COG1959	2 iron, 2 sulfur cluster binding
KM393_09455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM393_09460	COG0778	Nitroreductase
KM393_09470	COG0628	permease
KM393_09480	COG1231	oxidoreductase activity
KM393_09485	COG0523	cobalamin synthesis protein
KM393_09500	COG0318	PFAM AMP-dependent synthetase and ligase
KM393_09505	COG2030	dehydratase
KM393_09510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM393_09520	COG0411	ABC transporter
KM393_09540	COG0583	DNA-binding transcription factor activity
KM393_09550	COG1942	4-Oxalocrotonate Tautomerase
KM393_09560	COG1846	Transcriptional regulator
KM393_09570	COG1271	oxidase subunit
KM393_09575	COG1294	oxidase, subunit
KM393_09580	COG4988	ABC transporter
KM393_09585	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KM393_09605	COG1686	Belongs to the peptidase S11 family
KM393_09620	COG0791	NLP P60 protein
KM393_09620	COG1388	LysM domain
KM393_09635	COG0745	RESPONSE REGULATOR receiver
KM393_09640	COG5002	protein histidine kinase activity
KM393_09650	COG0300	oxidoreductase activity
KM393_09685	COG0460	homoserine dehydrogenase
KM393_09710	COG1316	TRANSCRIPTIONal
KM393_09720	COG0745	RESPONSE REGULATOR receiver
KM393_09725	COG5002	protein histidine kinase activity
KM393_09740	COG1285	pathogenesis
KM393_09745	COG1247	-acetyltransferase
KM393_09765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM393_09775	COG1082	Xylose isomerase domain protein TIM barrel
KM393_09790	COG1279	arginine transmembrane transporter activity
KM393_09800	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM393_09840	COG2002	toxin-antitoxin pair type II binding
KM393_09845	COG1404	Belongs to the peptidase S8 family
KM393_09850	COG0640	Transcriptional regulator
KM393_09855	COG0667	Aldo Keto reductase
KM393_09860	COG2814	Major facilitator Superfamily
KM393_09885	COG0840	transmembrane signaling receptor activity
KM393_09900	COG3949	Membrane
KM393_09905	COG0783	Belongs to the Dps family
KM393_09920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM393_09930	COG1231	oxidoreductase activity
KM393_09940	COG4989	oxidoreductase activity
KM393_09945	COG0523	cobalamin synthesis protein
KM393_09950	COG0456	acetyltransferase
KM393_10005	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM393_10005	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM393_10015	COG0702	epimerase
KM393_10025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM393_10035	COG4166	transmembrane transport
KM393_10050	COG0406	alpha-ribazole phosphatase activity
KM393_10060	COG5337	Spore coat protein CotH
KM393_10065	COG1051	belongs to the nudix hydrolase family
KM393_10070	COG0586	Pfam SNARE associated Golgi protein
KM393_10075	COG2244	polysaccharide biosynthetic process
KM393_10085	COG0701	Predicted permease
KM393_10090	COG3689	TIGRFAM TIGR03943 family protein
KM393_10095	COG1607	acyl-coa hydrolase
KM393_10105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM393_10120	COG0702	epimerase
KM393_10125	COG2839	Protein conserved in bacteria
KM393_10130	COG1253	flavin adenine dinucleotide binding
KM393_10145	COG1114	Component of the transport system for branched-chain amino acids
KM393_10150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM393_10170	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM393_10180	COG1876	peptidase activity
KM393_10190	COG0154	amidase activity
KM393_10195	COG2211	Major facilitator Superfamily
KM393_10215	COG0561	phosphatase activity
KM393_10225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM393_10230	COG4106	trans-aconitate 2-methyltransferase activity
KM393_10245	COG1819	glycosyl
KM393_10250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM393_10255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM393_10280	COG0456	acetyltransferase
KM393_10330	COG3874	Sporulation protein YtfJ
KM393_10355	COG2226	methyltransferase
KM393_10380	COG0346	lactoylglutathione lyase activity
KM393_10390	COG0604	alcohol dehydrogenase
KM393_10395	COG1595	DNA-templated transcription, initiation
KM393_10420	COG0386	Belongs to the glutathione peroxidase family
KM393_10425	COG1305	Transglutaminase-like
KM393_10430	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KM393_10435	COG0714	Associated with various cellular activities
KM393_10450	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KM393_10455	COG1140	nitrate reductase beta subunit
KM393_10460	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KM393_10465	COG2181	nitrate reductase activity
KM393_10485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM393_10490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KM393_10495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM393_10500	COG0303	'Molybdopterin
KM393_10505	COG0314	molybdopterin synthase activity
KM393_10515	COG2223	nitrite transmembrane transporter activity
KM393_10530	COG1648	precorrin-2 dehydrogenase activity
KM393_10540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KM393_10540	COG1587	Uroporphyrinogen-III synthase
KM393_10545	COG2146	nitrite reductase [NAD(P)H] activity
KM393_10550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM393_10555	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KM393_10590	COG2359	stage V sporulation protein S
KM393_10605	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM393_10620	COG1418	mRNA catabolic process
KM393_10625	COG0488	(ABC) transporter
KM393_10640	COG0629	single-stranded DNA binding
KM393_10655	COG1413	lyase activity
KM393_10670	COG2521	methyltransferase
KM393_10670	COG2136	Putative SAM-dependent methyltransferase
KM393_10675	COG0018	arginyl-trna synthetase
KM393_10700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KM393_10720	COG0017	Asparaginyl-tRNA synthetase
KM393_10740	COG1674	ftsk spoiiie
KM393_10810	COG1794	racemase activity, acting on amino acids and derivatives
KM393_10820	COG0456	acetyltransferase
KM393_10835	COG1131	(ABC) transporter
KM393_10850	COG0546	phosphoglycolate phosphatase activity
KM393_10870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM393_10885	COG0768	penicillin binding
KM393_10890	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM393_10895	COG0204	Acyl-transferase
KM393_10900	COG1272	protein, Hemolysin III
KM393_10910	COG0805	protein transport
KM393_10920	COG1307	EDD domain protein, DegV family
KM393_10925	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KM393_10930	COG1999	signal sequence binding
KM393_10935	COG0071	Belongs to the small heat shock protein (HSP20) family
KM393_10940	COG0367	asparagine synthase
KM393_10955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM393_10960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM393_10985	COG1051	belongs to the nudix hydrolase family
KM393_10995	COG0668	transmembrane transport
KM393_11000	COG4585	Histidine kinase
KM393_11000	COG2203	Gaf domain
KM393_11005	COG2197	response regulator
KM393_11015	COG1064	alcohol dehydrogenase
KM393_11040	COG1070	Carbohydrate kinase
KM393_11045	COG1070	Carbohydrate kinase
KM393_11075	COG1125	glycine betaine transport
KM393_11075	COG0517	IMP dehydrogenase activity
KM393_11080	COG1174	glycine betaine transport
KM393_11120	COG1012	belongs to the aldehyde dehydrogenase family
KM393_11125	COG5506	Protein of unknown function (DUF1694)
KM393_11140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM393_11145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KM393_11150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KM393_11155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM393_11160	COG0456	acetyltransferase
KM393_11165	COG3829	transcription factor binding
KM393_11170	COG1509	lysine 2,3-aminomutase activity
KM393_11210	COG4326	sporulation control protein
KM393_11215	COG0671	phosphoesterase, PA-phosphatase related
KM393_11220	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM393_11225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM393_11255	COG1715	Restriction endonuclease
KM393_11255	COG1787	Restriction endonuclease
KM393_11345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM393_11385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM393_11385	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM393_11390	COG2814	Major facilitator Superfamily
KM393_11395	COG4841	protein insertion into membrane
KM393_11400	COG0372	Belongs to the citrate synthase family
KM393_11405	COG2079	MmgE PrpD family protein
KM393_11410	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KM393_11415	COG1960	acyl-CoA dehydrogenase activity
KM393_11420	COG2084	Dehydrogenase
KM393_11430	COG1280	lysine exporter protein (LysE YggA)
KM393_11435	COG1024	Enoyl-CoA hydratase
KM393_11450	COG0420	3'-5' exonuclease activity
KM393_11455	COG0419	ATPase involved in DNA repair
KM393_11475	COG2223	nitrite transmembrane transporter activity
KM393_11480	COG1028	Short-chain dehydrogenase reductase Sdr
KM393_11485	COG1169	isochorismate synthase
KM393_11490	COG1021	2,3-dihydroxybenzoate-AMP ligase
KM393_11495	COG3433	isochorismatase activity
KM393_11495	COG1535	isochorismatase
KM393_11500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KM393_11505	COG3251	PFAM MbtH domain protein
KM393_11510	COG2814	Major facilitator Superfamily
KM393_11525	COG0776	regulation of translation
KM393_11535	COG2318	DinB family
KM393_11545	COG1115	amino acid carrier protein
KM393_11560	COG2329	Antibiotic biosynthesis monooxygenase
KM393_11565	COG1187	pseudouridine synthase activity
KM393_11570	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM393_11585	COG0596	Alpha beta hydrolase
KM393_11590	COG2814	Major facilitator Superfamily
KM393_11610	COG2226	methyltransferase
KM393_11655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM393_11690	COG1247	-acetyltransferase
KM393_11720	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM393_11730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM393_11740	COG1278	Cold shock
KM393_11755	COG0010	Belongs to the arginase family
KM393_11765	COG1132	(ABC) transporter
KM393_11785	COG1396	sequence-specific DNA binding
KM393_11810	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
KM393_11815	COG1595	DNA-templated transcription, initiation
KM393_11840	COG1649	PFAM Uncharacterised BCR, COG1649
KM393_11865	COG2971	BadF BadG BcrA BcrD
KM393_11870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM393_11875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KM393_11895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM393_11925	COG1309	transcriptional regulator
KM393_11940	COG0577	efflux transmembrane transporter activity
KM393_11940	COG1136	(ABC) transporter
KM393_11945	COG0500	methyltransferase
KM393_11945	COG3615	Tellurite resistance protein tehB
KM393_11955	COG2226	methyltransferase
KM393_11960	COG3961	Belongs to the TPP enzyme family
KM393_11965	COG1846	Transcriptional regulator
KM393_12005	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM393_12020	COG1595	DNA-templated transcription, initiation
KM393_12030	COG0768	penicillin binding
KM393_12040	COG2367	Beta-lactamase
KM393_12045	COG0671	phosphoesterase, PA-phosphatase related
KM393_12050	COG1609	Transcriptional regulator
KM393_12055	COG2814	Major facilitator Superfamily
KM393_12060	COG0673	inositol 2-dehydrogenase activity
KM393_12070	COG1012	belongs to the aldehyde dehydrogenase family
KM393_12085	COG0191	fructose-bisphosphate aldolase activity
KM393_12090	COG3718	enzyme involved in inositol metabolism
KM393_12115	COG0457	Tetratricopeptide repeat
KM393_12120	COG1476	TRANSCRIPTIONal
KM393_12135	COG1876	peptidase activity
KM393_12155	COG1309	transcriptional regulator
KM393_12160	COG0488	(ABC) transporter
KM393_12175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM393_12190	COG1252	NADH dehydrogenase
KM393_12195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM393_12210	COG1131	(ABC) transporter
KM393_12220	COG1309	transcriptional regulator
KM393_12235	COG1960	acyl-CoA dehydrogenase activity
KM393_12240	COG0439	Biotin carboxylase
KM393_12245	COG0511	ligase activity, forming carbon-carbon bonds
KM393_12250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KM393_12255	COG1024	Enoyl-CoA hydratase
KM393_12260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KM393_12265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM393_12275	COG1247	-acetyltransferase
KM393_12280	COG0572	uridine kinase
KM393_12290	COG2318	DinB family
KM393_12295	COG1686	Belongs to the peptidase S11 family
KM393_12320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KM393_12360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM393_12360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM393_12385	COG2814	Major facilitator Superfamily
KM393_12405	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM393_12425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM393_12440	COG1063	alcohol dehydrogenase
KM393_12470	COG3773	Cell wall hydrolase
KM393_12480	COG0745	RESPONSE REGULATOR receiver
KM393_12495	COG0488	(ABC) transporter
KM393_12510	COG1136	(ABC) transporter
KM393_12535	COG0460	homoserine dehydrogenase
KM393_12540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM393_12550	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM393_12615	COG2124	cytochrome p450
KM393_12650	COG0561	phosphatase activity
KM393_12660	COG5002	protein histidine kinase activity
KM393_12665	COG0768	penicillin binding
KM393_12670	COG1819	glycosyl
KM393_12675	COG1794	racemase activity, acting on amino acids and derivatives
KM393_12685	COG1122	ATPase activity
KM393_12700	COG2205	protein histidine kinase activity
KM393_12710	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM393_12715	COG0604	alcohol dehydrogenase
KM393_12720	COG0768	penicillin binding
KM393_12730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM393_12765	COG0693	protein deglycase activity
KM393_12795	COG2814	Major facilitator Superfamily
KM393_12810	COG0584	glycerophosphoryl diester phosphodiesterase
KM393_12830	COG0697	spore germination
KM393_12855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM393_12865	COG2223	nitrite transmembrane transporter activity
KM393_12880	COG2816	NAD+ diphosphatase activity
KM393_12885	COG0592	DNA-directed DNA polymerase activity
KM393_12890	COG1051	belongs to the nudix hydrolase family
KM393_12925	COG3878	Protein conserved in bacteria
KM393_12970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM393_12985	COG0322	excinuclease ABC activity
KM393_13025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM393_13050	COG1011	Hydrolase
KM393_13070	COG0076	glutamate decarboxylase activity
KM393_13085	COG1523	belongs to the glycosyl hydrolase 13 family
KM393_13090	COG3227	Zinc metalloprotease (Elastase)
KM393_13110	COG0201	protein transport
KM393_13120	COG0697	spore germination
KM393_13125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM393_13155	COG4129	membrane
KM393_13160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM393_13175	COG2959	enzyme of heme biosynthesis
KM393_13195	COG3483	tryptophan 2,3-dioxygenase activity
KM393_13200	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KM393_13205	COG3844	kynureninase activity
KM393_13210	COG1309	transcriptional regulator
KM393_13240	COG3284	Transcriptional regulator
KM393_13260	COG1349	DNA-binding transcription factor activity
KM393_13280	COG1959	2 iron, 2 sulfur cluster binding
KM393_13295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM393_13300	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM393_13305	COG0022	dehydrogenase e1 component
KM393_13310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM393_13320	COG1028	Short-chain dehydrogenase reductase Sdr
KM393_13325	COG0456	acetyltransferase
KM393_13325	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM393_13355	COG4176	ABC-type proline glycine betaine transport system permease component
KM393_13360	COG0517	IMP dehydrogenase activity
KM393_13360	COG4175	Glycine betaine
KM393_13385	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KM393_13390	COG2153	protein acetylation
KM393_13395	COG3397	chitin binding
KM393_13410	COG2205	protein histidine kinase activity
KM393_13435	COG0658	competence protein
KM393_13435	COG2333	competence protein COMEC
KM393_13485	COG3973	AAA domain
KM393_13500	COG2105	PFAM AIG2 family protein
KM393_13505	COG0514	ATP-dependent DNA helicase (RecQ)
KM393_13525	COG4637	Psort location Cytoplasmic, score
KM393_13550	COG3397	chitin binding
KM393_13565	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KM393_13570	COG1115	amino acid carrier protein
KM393_13575	COG1012	belongs to the aldehyde dehydrogenase family
KM393_13580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KM393_13590	COG3938	Belongs to the proline racemase family
KM393_13595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM393_13635	COG0586	Pfam SNARE associated Golgi protein
KM393_13650	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM393_13655	COG0519	Catalyzes the synthesis of GMP from XMP
KM393_13660	COG4166	transmembrane transport
KM393_13670	COG4948	Mandelate Racemase Muconate Lactonizing
KM393_13715	COG2936	dipeptidyl-peptidase activity
KM393_13720	COG5002	protein histidine kinase activity
KM393_13760	COG1164	Oligoendopeptidase f
KM393_13775	COG1307	EDD domain protein, DegV family
KM393_13795	COG2814	Major facilitator Superfamily
KM393_13805	COG1664	Polymer-forming cytoskeletal
KM393_13810	COG0789	Transcriptional regulator
KM393_13815	COG4533	DNA binding
KM393_13820	COG0477	Major facilitator Superfamily
KM393_13820	COG2814	Major facilitator Superfamily
KM393_13840	COG2261	transglycosylase associated protein
KM393_13855	COG2226	methyltransferase
KM393_13890	COG0436	Aminotransferase
KM393_13895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KM393_13900	COG5146	pantothenate kinase activity
KM393_13920	COG1131	(ABC) transporter
KM393_13960	COG0628	permease
KM393_13970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM393_13975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM393_13980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM393_13985	COG1116	anion transmembrane transporter activity
KM393_14005	COG2816	NAD+ diphosphatase activity
KM393_14025	COG2746	aminoglycoside 3-N-acetyltransferase activity
KM393_14050	COG0697	spore germination
KM393_14055	COG2318	DinB family
KM393_14075	COG4912	Dna alkylation repair
KM393_14095	COG0861	Integral membrane protein TerC family
KM393_14100	COG1368	sulfuric ester hydrolase activity
KM393_14105	COG0488	(ABC) transporter
KM393_14115	COG2409	Drug exporters of the RND superfamily
KM393_14115	COG1033	growth of symbiont in host cell
KM393_14120	COG1033	growth of symbiont in host cell
KM393_14120	COG2409	Drug exporters of the RND superfamily
KM393_14125	COG1033	growth of symbiont in host cell
KM393_14125	COG2409	Drug exporters of the RND superfamily
KM393_14130	COG1309	transcriptional regulator
KM393_14145	COG0287	Prephenate dehydrogenase
KM393_14150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM393_14155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KM393_14160	COG1605	Chorismate mutase
KM393_14160	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KM393_14195	COG1388	LysM domain
KM393_14195	COG3584	3D domain protein
KM393_14205	COG1595	DNA-templated transcription, initiation
KM393_14230	COG1879	ABC-type sugar transport system periplasmic component
KM393_14240	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM393_14250	COG2390	Transcriptional regulator
KM393_14285	COG2329	Antibiotic biosynthesis monooxygenase
KM393_14315	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KM393_14320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM393_14325	COG4187	Peptidase family M20/M25/M40
KM393_14330	COG1414	Transcriptional regulator
KM393_14335	COG0833	amino acid
KM393_14340	COG1690	Belongs to the RtcB family
KM393_14345	COG3239	Fatty acid desaturase
KM393_14350	COG1785	Belongs to the alkaline phosphatase family
KM393_14360	COG3655	Transcriptional regulator
KM393_14375	COG4377	Putative membrane peptidase family (DUF2324)
KM393_14385	COG3279	Response regulator of the LytR AlgR family
KM393_14395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM393_14400	COG0346	lactoylglutathione lyase activity
KM393_14420	COG0714	Associated with various cellular activities
KM393_14445	COG0463	Glycosyl transferase, family 2
KM393_14470	COG0463	Glycosyl transferase, family 2
KM393_14480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM393_14485	COG0753	catalase activity
KM393_14495	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KM393_14520	COG0714	Associated with various cellular activities
KM393_14530	COG0778	Nitroreductase
KM393_14535	COG1846	Transcriptional regulator
KM393_14570	COG1725	Transcriptional regulator
KM393_14580	COG0577	efflux transmembrane transporter activity
KM393_14580	COG1136	(ABC) transporter
KM393_14605	COG2207	Transcriptional regulator
KM393_14610	COG0456	acetyltransferase
KM393_14630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM393_14650	COG0642	Histidine kinase
KM393_14655	COG0745	RESPONSE REGULATOR receiver
KM393_14660	COG0596	Alpha beta hydrolase
KM393_14690	COG0730	response to heat
KM393_14700	COG0833	amino acid
KM393_14710	COG4335	DNA alkylation repair
KM393_14750	COG0768	penicillin binding
KM393_14760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KM393_14790	COG1984	allophanate hydrolase subunit 2
KM393_14795	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KM393_14800	COG1414	Transcriptional regulator
KM393_14815	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM393_14820	COG0640	Transcriptional regulator
KM393_14830	COG1960	acyl-CoA dehydrogenase activity
KM393_14845	COG3314	Sporulation integral membrane protein YlbJ
KM393_14860	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KM393_14875	COG3848	Pyruvate phosphate dikinase
KM393_14875	COG0574	Belongs to the PEP-utilizing enzyme family
KM393_14880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM393_14895	COG5577	PFAM Coat F domain
KM393_14900	COG3403	YqcI/YcgG family
KM393_14905	COG1280	lysine exporter protein (LysE YggA)
KM393_14940	COG1063	alcohol dehydrogenase
KM393_14955	COG1027	Aspartate ammonia-lyase
KM393_14960	COG0252	asparaginase activity
KM393_14965	COG1396	sequence-specific DNA binding
KM393_14975	COG0322	excinuclease ABC activity
KM393_14980	COG0531	amino acid
KM393_14985	COG1114	Component of the transport system for branched-chain amino acids
KM393_14990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM393_15000	COG0281	malic enzyme
KM393_15015	COG0531	amino acid
KM393_15025	COG0784	Response regulator, receiver
KM393_15035	COG2066	Belongs to the glutaminase family
KM393_15040	COG1115	amino acid carrier protein
KM393_15070	COG0737	Belongs to the 5'-nucleotidase family
KM393_15075	COG0753	catalase activity
KM393_15080	COG2267	carboxylic ester hydrolase activity
KM393_15085	COG1335	isochorismatase
KM393_15105	COG0583	DNA-binding transcription factor activity
KM393_15110	COG1846	Transcriptional regulator
KM393_15150	COG0415	Belongs to the DNA photolyase family
KM393_15155	COG0288	reversible hydration of carbon dioxide
KM393_15165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM393_15170	COG5609	conserved protein (DUF2294)
KM393_15185	COG1575	Belongs to the MenA family. Type 1 subfamily
KM393_15190	COG2267	carboxylic ester hydrolase activity
KM393_15195	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM393_15200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM393_15205	COG1121	(ABC) transporter
KM393_15235	COG0798	PFAM Bile acid sodium symporter
KM393_15240	COG0346	lactoylglutathione lyase activity
KM393_15245	COG0640	Transcriptional regulator
KM393_15260	COG0443	Heat shock 70 kDa protein
KM393_15275	COG1522	sequence-specific DNA binding
KM393_15290	COG0346	lactoylglutathione lyase activity
KM393_15315	COG2169	Transcriptional regulator
KM393_15360	COG2814	Major facilitator Superfamily
KM393_15385	COG0745	RESPONSE REGULATOR receiver
KM393_15390	COG3850	Histidine kinase
KM393_15390	COG5002	protein histidine kinase activity
KM393_15415	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KM393_15435	COG1476	TRANSCRIPTIONal
KM393_15450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM393_15455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM393_15465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM393_15470	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KM393_15485	COG1136	(ABC) transporter
KM393_15490	COG0577	efflux transmembrane transporter activity
KM393_15505	COG3850	Histidine kinase
KM393_15505	COG5002	protein histidine kinase activity
KM393_15515	COG2364	Membrane
KM393_15520	COG1846	Transcriptional regulator
KM393_15530	COG2808	Putative FMN-binding domain
KM393_15535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM393_15540	COG2271	Major facilitator Superfamily
KM393_15545	COG1556	Lactate utilization protein
KM393_15550	COG1139	Iron-sulfur cluster binding protein
KM393_15560	COG0583	DNA-binding transcription factor activity
KM393_15570	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM393_15590	COG0738	Major facilitator superfamily
KM393_15595	COG0673	inositol 2-dehydrogenase activity
KM393_15600	COG0561	phosphatase activity
KM393_15610	COG1609	Transcriptional regulator
KM393_15615	COG0457	Tetratricopeptide repeat
KM393_15635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM393_15665	COG0534	Mate efflux family protein
KM393_15685	COG2814	Major facilitator Superfamily
KM393_15690	COG1309	transcriptional regulator
KM393_15705	COG0814	amino acid
KM393_15710	COG1760	l-serine dehydratase
KM393_15715	COG1760	l-serine dehydratase
KM393_15725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM393_15730	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KM393_15740	COG1335	isochorismatase
KM393_15745	COG1522	sequence-specific DNA binding
KM393_15750	COG0531	amino acid
KM393_15765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KM393_15785	COG1595	DNA-templated transcription, initiation
KM393_15800	COG0662	Cupin 2, conserved barrel domain protein
KM393_15805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM393_15805	COG2207	Transcriptional regulator
KM393_15855	COG0477	Major facilitator Superfamily
KM393_15865	COG1846	Transcriptional regulator
KM393_15870	COG2814	Major facilitator Superfamily
KM393_15880	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM393_15885	COG1131	(ABC) transporter
KM393_15905	COG2076	Multidrug Resistance protein
KM393_15910	COG1309	transcriptional regulator
KM393_15920	COG2031	fatty acid transporter
KM393_15930	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM393_15960	COG1122	ATPase activity
KM393_15965	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM393_15980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KM393_15985	COG1288	antiporter activity
KM393_15990	COG2356	endonuclease I
KM393_16005	COG3620	sequence-specific DNA binding
KM393_16010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM393_16015	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KM393_16020	COG0124	histidyl-tRNA synthetase
KM393_16035	COG1733	regulation of RNA biosynthetic process
KM393_16040	COG0778	Nitroreductase
KM393_16060	COG1028	Short-chain dehydrogenase reductase Sdr
KM393_16070	COG1131	(ABC) transporter
KM393_16095	COG1011	Hydrolase
KM393_16105	COG2365	Tyrosine phosphatase family
KM393_16130	COG0346	lactoylglutathione lyase activity
KM393_16135	COG1940	carbohydrate kinase activity
KM393_16140	COG0738	Major facilitator superfamily
KM393_16145	COG0110	maltose O-acetyltransferase activity
KM393_16155	COG1136	(ABC) transporter
KM393_16155	COG0577	efflux transmembrane transporter activity
KM393_16170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KM393_16175	COG0628	permease
KM393_16195	COG2226	methyltransferase
KM393_16205	COG0477	Major facilitator Superfamily
KM393_16235	COG1253	flavin adenine dinucleotide binding
KM393_16240	COG0789	Transcriptional regulator
KM393_16245	COG0697	spore germination
KM393_16250	COG1357	PFAM Pentapeptide repeats (8 copies)
KM393_16255	COG3813	Protein conserved in bacteria
KM393_16260	COG2706	6-phosphogluconolactonase activity
KM393_16265	COG1070	Carbohydrate kinase
KM393_16275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KM393_16280	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KM393_16290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM393_16295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM393_16300	COG0604	alcohol dehydrogenase
KM393_16305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM393_16315	COG0604	alcohol dehydrogenase
KM393_16315	COG3321	synthase
KM393_16320	COG1028	Short-chain dehydrogenase reductase Sdr
KM393_16345	COG0656	L-ascorbic acid biosynthetic process
KM393_16350	COG2814	Major facilitator Superfamily
KM393_16365	COG0346	lactoylglutathione lyase activity
KM393_16370	COG0814	amino acid
KM393_16395	COG1393	Belongs to the ArsC family
KM393_16400	COG1733	regulation of RNA biosynthetic process
KM393_16405	COG2188	Transcriptional regulator
KM393_16415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KM393_16420	COG1733	regulation of RNA biosynthetic process
KM393_16425	COG1733	regulation of RNA biosynthetic process
KM393_16440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM393_16460	COG0384	phenazine biosynthesis protein PhzF
KM393_16470	COG1028	Short-chain dehydrogenase reductase Sdr
KM393_16480	COG0318	PFAM AMP-dependent synthetase and ligase
KM393_16490	COG1733	regulation of RNA biosynthetic process
KM393_16525	COG1191	sigma factor activity
KM393_16540	COG1309	transcriptional regulator
KM393_16560	COG3152	Membrane
KM393_16585	COG1151	hydroxylamine reductase activity
KM393_16595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM393_16600	COG3409	Peptidoglycan-binding domain 1 protein
KM393_16600	COG3757	hydrolase, family 25
KM393_16635	COG2072	flavoprotein involved in K transport
KM393_16670	COG0604	alcohol dehydrogenase
KM393_16675	COG1113	amino acid transport
KM393_16680	COG2814	Major facilitator Superfamily
KM393_16710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM393_16715	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM393_16735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM393_16740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM393_16745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM393_16750	COG3739	integral membrane protein
KM393_16755	COG0384	phenazine biosynthesis protein PhzF
KM393_16785	COG0583	DNA-binding transcription factor activity
KM393_16805	COG1193	negative regulation of DNA recombination
KM393_16830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM393_16860	COG0584	glycerophosphoryl diester phosphodiesterase
KM393_16885	COG0640	Transcriptional regulator
KM393_16890	COG0604	alcohol dehydrogenase
KM393_16910	COG2808	Putative FMN-binding domain
KM393_16915	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM393_16925	COG0385	Bile acid
KM393_16930	COG0277	FAD linked oxidase domain protein
KM393_16960	COG1216	Glycosyl transferase, family 2
KM393_16965	COG1024	Enoyl-CoA hydratase
KM393_16975	COG1285	pathogenesis
KM393_16990	COG2514	catechol 2,3-dioxygenase activity
KM393_16995	COG2720	vancomycin resistance protein
KM393_17035	COG0716	FMN binding
KM393_17065	COG1028	Short-chain dehydrogenase reductase Sdr
KM393_17075	COG0165	Argininosuccinate lyase
KM393_17090	COG4145	pantothenate transmembrane transporter activity
KM393_17100	COG1012	belongs to the aldehyde dehydrogenase family
KM393_17105	COG1028	Short-chain dehydrogenase reductase Sdr
KM393_17115	COG1657	PFAM Prenyltransferase squalene oxidase
KM393_17120	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KM393_17125	COG2962	Rard protein
KM393_17130	COG3326	Membrane
KM393_17145	COG0489	protein tyrosine kinase activity
KM393_17155	COG0314	molybdopterin synthase activity
KM393_17160	COG0303	'Molybdopterin
KM393_17165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM393_17170	COG2116	formate transmembrane transporter activity
KM393_17180	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM393_17185	COG5609	conserved protein (DUF2294)
KM393_17190	COG2427	Protein of unknown function (DUF1641)
KM393_17195	COG3383	formate dehydrogenase (NAD+) activity
KM393_17200	COG0697	spore germination
KM393_17240	COG2226	methyltransferase
KM393_17245	COG4166	transmembrane transport
KM393_17250	COG4166	transmembrane transport
KM393_17255	COG4166	transmembrane transport
KM393_17260	COG1301	dicarboxylic acid transport
KM393_17265	COG1316	TRANSCRIPTIONal
KM393_17275	COG1595	DNA-templated transcription, initiation
KM393_17295	COG1131	(ABC) transporter
KM393_17305	COG0673	inositol 2-dehydrogenase activity
KM393_17310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM393_17315	COG0187	DNA topoisomerase II activity
KM393_17320	COG1832	CoA-binding protein
KM393_17325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM393_17330	COG0745	RESPONSE REGULATOR receiver
KM393_17345	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM393_17350	COG4841	protein insertion into membrane
KM393_17355	COG0824	Thioesterase
KM393_17385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM393_17395	COG2274	protein secretion by the type I secretion system
KM393_17400	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KM393_17440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM393_17455	COG0183	Belongs to the thiolase family
KM393_17460	COG0318	PFAM AMP-dependent synthetase and ligase
KM393_17465	COG1268	BioY protein
KM393_17470	COG0318	PFAM AMP-dependent synthetase and ligase
KM393_17520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM393_17535	COG0400	carboxylic ester hydrolase activity
KM393_17540	COG0346	lactoylglutathione lyase activity
KM393_17545	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM393_17550	COG0069	glutamate synthase activity
KM393_17555	COG1902	pentaerythritol trinitrate reductase activity
KM393_17560	COG1329	Transcriptional regulator
KM393_17565	COG0010	Belongs to the arginase family
KM393_17590	COG2226	methyltransferase
KM393_17645	COG4846	Membrane protein involved in cytochrome C biogenesis
KM393_17650	COG0785	Cytochrome C biogenesis protein
KM393_17660	COG0583	DNA-binding transcription factor activity
KM393_17665	COG1380	Effector of murein hydrolase LrgA
KM393_17670	COG1346	cytolysis
KM393_17695	COG3409	Peptidoglycan-binding domain 1 protein
KM393_17695	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM393_17710	COG1132	(ABC) transporter
KM393_17715	COG1132	(ABC) transporter
KM393_17745	COG3639	organic phosphonate transmembrane transporter activity
KM393_17750	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KM393_17770	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KM393_17790	COG1695	Transcriptional regulator
KM393_17825	COG1388	LysM domain
KM393_17825	COG3409	Peptidoglycan-binding domain 1 protein
KM393_17825	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM393_17830	COG4824	toxin secretion phage lysis holin
KM393_17985	COG1595	DNA-templated transcription, initiation
KM393_18030	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KM393_18110	COG1396	sequence-specific DNA binding
KM393_18135	COG0174	glutamine synthetase
KM393_18140	COG0789	Transcriptional regulator
KM393_18145	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KM393_18155	COG2860	membrane
KM393_18165	COG0464	growth
KM393_18195	COG1388	LysM domain
KM393_18195	COG3584	3D domain protein
KM393_18200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM393_18200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM393_18200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM393_18205	COG1105	Belongs to the carbohydrate kinase PfkB family
KM393_18210	COG1349	DNA-binding transcription factor activity
KM393_18220	COG2322	membrane
KM393_18230	COG1113	amino acid transport
KM393_18245	COG1408	metallophosphoesterase
KM393_18250	COG2116	formate transmembrane transporter activity
KM393_18260	COG2217	Heavy metal translocating P-type atpase
KM393_18265	COG2608	mercury ion transmembrane transporter activity
KM393_18270	COG1937	Protein conserved in bacteria
KM393_18280	COG2819	hydrolase of the alpha beta superfamily
KM393_18285	COG1120	ATPase activity
KM393_18290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM393_18295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM393_18300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM393_18305	COG0708	Exodeoxyribonuclease III
KM393_18310	COG2169	Transcriptional regulator
KM393_18315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM393_18320	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM393_18330	COG2364	Membrane
KM393_18345	COG2267	carboxylic ester hydrolase activity
KM393_18350	COG0346	lactoylglutathione lyase activity
KM393_18355	COG5001	Diguanylate cyclase
KM393_18355	COG3300	MHYT domain
KM393_18370	COG1346	cytolysis
KM393_18375	COG1380	Effector of murein hydrolase LrgA
KM393_18380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM393_18385	COG0596	Alpha beta hydrolase
KM393_18385	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM393_18390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM393_18410	COG1404	Belongs to the peptidase S8 family
KM393_18415	COG3773	Cell wall hydrolase
KM393_18420	COG0562	UDP-galactopyranose mutase
KM393_18425	COG1368	sulfuric ester hydrolase activity
KM393_18430	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM393_18440	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KM393_18465	COG1131	(ABC) transporter
KM393_18485	COG4550	Control of competence regulator ComK, YlbF/YmcA
KM393_18490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM393_18495	COG1013	pyruvate-flavodoxin oxidoreductase activity
KM393_18500	COG0674	pyruvate-flavodoxin oxidoreductase activity
KM393_18500	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KM393_18510	COG2359	stage V sporulation protein S
KM393_18515	COG1692	metallophosphoesterase
KM393_18540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KM393_18545	COG1426	Protein conserved in bacteria
KM393_18560	COG0300	oxidoreductase activity
KM393_18565	COG0612	Peptidase, M16
KM393_18570	COG0612	Peptidase, M16
KM393_18575	COG1079	Belongs to the binding-protein-dependent transport system permease family
KM393_18585	COG3845	ABC transporter
KM393_18590	COG1744	ABC transporter substrate-binding protein PnrA-like
KM393_18595	COG2188	Transcriptional regulator
KM393_18600	COG1674	ftsk spoiiie
KM393_18610	COG0740	serine-type endopeptidase activity
KM393_18615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM393_18625	COG0527	aspartate kinase activity
KM393_18630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM393_18635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM393_18640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM393_18645	COG1873	PFAM PRC-barrel domain
KM393_18650	COG0612	Peptidase, M16
KM393_18655	COG0726	polysaccharide deacetylase
KM393_18670	COG0196	riboflavin kinase activity
KM393_18675	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KM393_18685	COG1550	Protein conserved in bacteria
KM393_18695	COG1358	cellular component organization or biogenesis
KM393_18700	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KM393_18705	COG0195	Participates in both transcription termination and antitermination
KM393_18725	COG0750	zinc metalloprotease
KM393_18735	COG4589	Belongs to the CDS family
KM393_18740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KM393_18750	COG0528	UMP kinase activity
KM393_18780	COG4974	Belongs to the 'phage' integrase family
KM393_18790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM393_18800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KM393_18840	COG1837	Belongs to the UPF0109 family
KM393_18850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KM393_18860	COG0552	protein localization to endoplasmic reticulum
KM393_18865	COG1196	nuclear chromosome segregation
KM393_18875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM393_18880	COG1028	Short-chain dehydrogenase reductase Sdr
KM393_18885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KM393_18900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KM393_18905	COG1461	Dihydroxyacetone kinase
KM393_18910	COG1302	Protein conserved in bacteria
KM393_18925	COG1564	THIamine pyrophosphokinase
KM393_18930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KM393_18935	COG1162	GTPase activity
KM393_18940	COG0515	serine threonine protein kinase
KM393_18940	COG2815	serine threonine protein kinase
KM393_18945	COG0631	protein serine/threonine phosphatase activity
KM393_18955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KM393_18955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KM393_18965	COG0242	peptide deformylase activity
KM393_18970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KM393_18975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM393_18995	COG1561	YicC-like family, N-terminal region
KM393_19000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KM393_19010	COG0006	proline dipeptidase activity
KM393_19025	COG3069	C4-dicarboxylate transmembrane transporter activity
KM393_19090	COG0564	pseudouridine synthase activity
KM393_19110	COG3599	regulation of cell shape
KM393_19115	COG2302	S4 RNA-binding domain
KM393_19120	COG0762	integral membrane protein
KM393_19130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KM393_19135	COG1496	oxidoreductase activity
KM393_19140	COG1873	PFAM PRC-barrel domain
KM393_19145	COG1191	sigma factor activity
KM393_19150	COG1191	sigma factor activity
KM393_19160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KM393_19165	COG0849	cell division
KM393_19170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KM393_19175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM393_19185	COG0772	Belongs to the SEDS family
KM393_19200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KM393_19205	COG0768	penicillin binding
KM393_19210	COG0768	penicillin binding
KM393_19215	COG4839	cell division protein FtsL
KM393_19230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM393_19245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KM393_19250	COG1399	metal-binding, possibly nucleic acid-binding protein
KM393_19300	COG4824	toxin secretion phage lysis holin
KM393_19385	COG4626	Terminase
KM393_19385	COG1802	Transcriptional regulator
KM393_19475	COG0756	dUTP diphosphatase activity
KM393_19490	COG1191	sigma factor activity
KM393_19515	COG1484	DNA-dependent DNA replication
KM393_19545	COG1396	sequence-specific DNA binding
KM393_19560	COG1396	sequence-specific DNA binding
KM393_19575	COG0582	viral genome integration into host DNA
KM393_19585	COG3480	Lon protease (S16) C-terminal proteolytic domain
KM393_19590	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM393_19595	COG3314	Sporulation integral membrane protein YlbJ
KM393_19605	COG0742	ribosomal rna small subunit methyltransferase
KM393_19620	COG3679	Belongs to the UPF0342 family
KM393_19625	COG0406	alpha-ribazole phosphatase activity
KM393_19640	COG2340	Cysteine-rich secretory protein family
KM393_19655	COG3336	cytochrome c oxidase
KM393_19690	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KM393_19695	COG0772	Belongs to the SEDS family
KM393_19705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KM393_19710	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KM393_19720	COG4896	Protein conserved in bacteria
KM393_19735	COG1217	gtp-binding protein TYPA
KM393_19745	COG0483	inositol monophosphate 1-phosphatase activity
KM393_19765	COG1982	Orn Lys Arg decarboxylase major
KM393_19810	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM393_19815	COG0022	dehydrogenase e1 component
KM393_19820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM393_19830	COG0242	peptide deformylase activity
KM393_19835	COG0561	phosphatase activity
KM393_19845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM393_19850	COG0569	domain protein
KM393_19870	COG0583	DNA-binding transcription factor activity
KM393_19875	COG0517	IMP dehydrogenase activity
KM393_19885	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
KM393_19895	COG4703	Protein of unknown function (DUF1797)
KM393_19910	COG2200	EAL domain
KM393_19915	COG1028	Short-chain dehydrogenase reductase Sdr
KM393_19920	COG1408	metallophosphoesterase
KM393_19930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KM393_19965	COG2814	Major facilitator Superfamily
KM393_19985	COG3209	COG3209 Rhs family protein
KM393_19995	COG2205	protein histidine kinase activity
KM393_20005	COG0436	Aminotransferase
KM393_20010	COG1609	Transcriptional regulator
KM393_20015	COG3833	ABC-type maltose transport systems, permease component
KM393_20020	COG1175	transmembrane transport
KM393_20025	COG2182	Extracellular solute-binding protein
KM393_20035	COG0366	Alpha amylase catalytic
KM393_20040	COG3842	ATPase activity
KM393_20080	COG0183	Belongs to the thiolase family
KM393_20115	COG1695	Transcriptional regulator
KM393_20120	COG1028	Short-chain dehydrogenase reductase Sdr
KM393_20130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KM393_20140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KM393_20145	COG0436	Aminotransferase
KM393_20165	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KM393_20185	COG2199	diguanylate cyclase activity
KM393_20190	COG0778	Nitroreductase
KM393_20215	COG1263	PTS System
KM393_20215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM393_20215	COG2190	(PTS) system
KM393_20220	COG3711	transcriptional antiterminator
KM393_20230	COG2188	Transcriptional regulator
KM393_20240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KM393_20265	COG1547	Domain of unknown function (DUF309)
KM393_20270	COG0456	acetyltransferase
KM393_20275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KM393_20280	COG4086	secreted protein
KM393_20285	COG0561	phosphatase activity
KM393_20290	COG0697	spore germination
KM393_20305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM393_20330	COG0733	neurotransmitter:sodium symporter activity
KM393_20350	COG1686	Belongs to the peptidase S11 family
KM393_20355	COG1725	Transcriptional regulator
KM393_20360	COG1131	(ABC) transporter
KM393_20375	COG1846	Transcriptional regulator
KM393_20390	COG0598	Magnesium transport protein CorA
KM393_20415	COG4974	Belongs to the 'phage' integrase family
KM393_20425	COG0735	belongs to the Fur family
KM393_20430	COG1300	Membrane
KM393_20450	COG0667	Aldo Keto reductase
KM393_20455	COG0656	L-ascorbic acid biosynthetic process
KM393_20460	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM393_20460	COG0456	acetyltransferase
KM393_20470	COG0737	Belongs to the 5'-nucleotidase family
KM393_20470	COG1525	nuclease
KM393_20470	COG4085	toxin activity
KM393_20480	COG0596	Alpha beta hydrolase
KM393_20485	COG2056	Na+-H+ antiporter family
KM393_20490	COG1609	Transcriptional regulator
KM393_20495	COG0456	acetyltransferase
KM393_20500	COG1073	alpha beta
KM393_20515	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM393_20515	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM393_20520	COG0307	riboflavin synthase, alpha
KM393_20545	COG4106	trans-aconitate 2-methyltransferase activity
KM393_20550	COG1073	alpha beta
KM393_20550	COG2226	methyltransferase
KM393_20565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM393_20575	COG1757	Na H antiporter
KM393_20580	COG0737	Belongs to the 5'-nucleotidase family
KM393_20590	COG1522	sequence-specific DNA binding
KM393_20610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM393_20620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KM393_20635	COG0300	oxidoreductase activity
KM393_20645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM393_20650	COG1760	l-serine dehydratase
KM393_20655	COG1760	l-serine dehydratase
KM393_20675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM393_20685	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM393_20690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM393_20705	COG1376	ErfK ybiS ycfS ynhG family protein
KM393_20710	COG4129	membrane
KM393_20715	COG1126	abc transporter atp-binding protein
KM393_20720	COG0765	amino acid transport
KM393_20725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM393_20745	COG0772	Belongs to the SEDS family
KM393_20750	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM393_20755	COG0022	dehydrogenase e1 component
KM393_20760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM393_20765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM393_20780	COG0280	phosphate acetyltransferase
KM393_20785	COG3829	transcription factor binding
KM393_20785	COG3290	protein histidine kinase activity
KM393_20795	COG0584	glycerophosphoryl diester phosphodiesterase
KM393_20800	COG3093	addiction module antidote protein HigA
KM393_20810	COG0745	RESPONSE REGULATOR receiver
KM393_20815	COG0750	zinc metalloprotease
KM393_20820	COG0497	DNA recombination
KM393_20830	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KM393_20840	COG0142	geranyltranstransferase activity
KM393_20865	COG1302	Protein conserved in bacteria
KM393_20870	COG0439	Biotin carboxylase
KM393_20875	COG0511	ligase activity, forming carbon-carbon bonds
KM393_20920	COG3854	ATPases associated with a variety of cellular activities
KM393_20945	COG0006	proline dipeptidase activity
KM393_20960	COG3872	metal-dependent enzyme
KM393_20970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KM393_20990	COG0095	Lipoate-protein ligase
KM393_20995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM393_21000	COG1609	Transcriptional regulator
KM393_21010	COG2076	Multidrug Resistance protein
KM393_21015	COG2076	Multidrug Resistance protein
KM393_21050	COG1131	(ABC) transporter
KM393_21055	COG1725	Transcriptional regulator
KM393_21085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM393_21140	COG4970	Tfp pilus assembly protein FimT
KM393_21150	COG1459	type II secretion system
KM393_21155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KM393_21205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KM393_21210	COG0646	methionine synthase
KM393_21210	COG1410	methionine synthase
KM393_21215	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KM393_21215	COG0646	methionine synthase
KM393_21220	COG0626	cystathionine gamma-synthase activity
KM393_21225	COG0626	cystathionine gamma-synthase activity
KM393_21245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM393_21255	COG1940	carbohydrate kinase activity
KM393_21260	COG4483	Protein conserved in bacteria
KM393_21265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KM393_21270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KM393_21275	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KM393_21280	COG0704	Plays a role in the regulation of phosphate uptake
KM393_21290	COG0581	inorganic phosphate transmembrane transporter activity
KM393_21295	COG0573	inorganic phosphate transmembrane transporter activity
KM393_21300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM393_21305	COG0768	penicillin binding
KM393_21310	COG0477	Major facilitator Superfamily
KM393_21315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM393_21340	COG0735	belongs to the Fur family
KM393_21345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM393_21350	COG1121	(ABC) transporter
KM393_21355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM393_21385	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM393_21390	COG2384	SAM-dependent methyltransferase
KM393_21395	COG2010	Cytochrome c
KM393_21400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM393_21405	COG0358	DNA primase activity
KM393_21415	COG0517	IMP dehydrogenase activity
KM393_21430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KM393_21435	COG0295	cytidine deaminase activity
KM393_21440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KM393_21455	COG1702	phosphate starvation-inducible protein PhoH
KM393_21470	COG1610	YqeY-like protein
KM393_21475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KM393_21480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM393_21485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KM393_21515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM393_21520	COG1733	regulation of RNA biosynthetic process
KM393_21545	COG1466	dna polymerase III delta subunit
KM393_21555	COG0658	competence protein
KM393_21555	COG2333	competence protein COMEC
KM393_21560	COG2131	deaminase
KM393_21565	COG1555	photosystem II stabilization
KM393_21565	COG1596	polysaccharide export
KM393_21570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM393_21575	COG2226	methyltransferase
KM393_21580	COG0799	negative regulation of ribosome biogenesis
KM393_21585	COG1713	HD superfamily hydrolase involved in NAD metabolism
KM393_21595	COG1534	Rna-binding protein
KM393_21605	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KM393_21610	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KM393_21635	COG1595	DNA-templated transcription, initiation
KM393_21645	COG0778	Nitroreductase
KM393_21650	COG2357	RelA SpoT domain protein
KM393_21660	COG1785	Belongs to the alkaline phosphatase family
KM393_21670	COG2267	carboxylic ester hydrolase activity
KM393_21705	COG1404	Belongs to the peptidase S8 family
KM393_21710	COG3186	Phenylalanine-4-hydroxylase
KM393_21725	COG2259	Doxx family
KM393_21765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM393_21775	COG1012	belongs to the aldehyde dehydrogenase family
KM393_21775	COG1454	alcohol dehydrogenase
KM393_21780	COG0626	cystathionine gamma-synthase activity
KM393_21785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM393_21810	COG0768	penicillin binding
KM393_21825	COG0826	peptidase U32
KM393_21830	COG0826	peptidase U32
KM393_21835	COG4122	O-methyltransferase activity
KM393_21840	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KM393_21860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM393_21870	COG0628	permease
KM393_21890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KM393_21900	COG0482	sulfurtransferase activity
KM393_21905	COG1104	cysteine desulfurase activity
KM393_21910	COG1959	2 iron, 2 sulfur cluster binding
KM393_21915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KM393_21925	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KM393_21950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KM393_21960	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KM393_21960	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KM393_21965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM393_21970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM393_21970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM393_21980	COG2244	polysaccharide biosynthetic process
KM393_21985	COG2323	membrane
KM393_21995	COG1862	Preprotein translocase
KM393_22025	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KM393_22035	COG0697	spore germination
KM393_22040	COG0697	spore germination
KM393_22045	COG0640	Transcriptional regulator
KM393_22070	COG0157	Belongs to the NadC ModD family
KM393_22075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KM393_22080	COG1104	cysteine desulfurase activity
KM393_22085	COG1827	regulation of RNA biosynthetic process
KM393_22090	COG2258	MOSC domain
KM393_22095	COG0077	Prephenate dehydratase
KM393_22100	COG0577	efflux transmembrane transporter activity
KM393_22105	COG0577	efflux transmembrane transporter activity
KM393_22110	COG1136	(ABC) transporter
KM393_22120	COG0745	RESPONSE REGULATOR receiver
KM393_22125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KM393_22130	COG3290	protein histidine kinase activity
KM393_22140	COG2868	ribosomal protein
KM393_22150	COG1530	ribonuclease E activity
KM393_22155	COG1994	Peptidase M50
KM393_22160	COG0739	heme binding
KM393_22165	COG2894	cell division
KM393_22185	COG1077	Cell shape determining protein MreB Mrl
KM393_22205	COG0285	dihydrofolate synthase activity
KM393_22210	COG0525	valine-tRNA ligase activity
KM393_22220	COG1388	LysM domain
KM393_22230	COG0113	porphobilinogen synthase activity
KM393_22235	COG1587	Uroporphyrinogen-III synthase
KM393_22245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM393_22255	COG1846	Transcriptional regulator
KM393_22260	COG1764	response to oxidative stress
KM393_22275	COG0470	DNA polymerase III
KM393_22275	COG1067	ATP-dependent peptidase activity
KM393_22320	COG0622	Phosphoesterase
KM393_22335	COG5401	PFAM Sporulation and spore germination
KM393_22355	COG1309	transcriptional regulator
KM393_22370	COG2197	response regulator
KM393_22375	COG2233	PERMEase
KM393_22385	COG0402	S-adenosylhomocysteine deaminase activity
KM393_22390	COG0402	S-adenosylhomocysteine deaminase activity
KM393_22400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM393_22410	COG0444	Belongs to the ABC transporter superfamily
KM393_22415	COG4608	Belongs to the ABC transporter superfamily
KM393_22420	COG3275	phosphorelay sensor kinase activity
KM393_22425	COG3279	Response regulator of the LytR AlgR family
KM393_22440	COG1983	PspC domain protein
KM393_22445	COG1396	sequence-specific DNA binding
KM393_22450	COG0697	spore germination
KM393_22460	COG1959	2 iron, 2 sulfur cluster binding
KM393_22465	COG1668	transmembrane transport
KM393_22470	COG4152	abc transporter atp-binding protein
KM393_22475	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KM393_22485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM393_22490	COG1876	peptidase activity
KM393_22495	COG0824	Thioesterase
KM393_22500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KM393_22505	COG1053	succinate dehydrogenase
KM393_22510	COG2009	succinate dehydrogenase
KM393_22515	COG1719	4-vinyl reductase, 4VR
KM393_22525	COG3118	belongs to the thioredoxin family
KM393_22530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KM393_22535	COG2086	electron transfer activity
KM393_22540	COG1024	Enoyl-CoA hydratase
KM393_22545	COG1309	transcriptional regulator
KM393_22550	COG0318	PFAM AMP-dependent synthetase and ligase
KM393_22570	COG2318	DinB family
KM393_22600	COG1131	(ABC) transporter
KM393_22605	COG2205	protein histidine kinase activity
KM393_22610	COG0745	RESPONSE REGULATOR receiver
KM393_22620	COG4895	conserved protein (DUF2196)
KM393_22625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KM393_22640	COG4509	Sortase family
KM393_22645	COG1120	ATPase activity
KM393_22660	COG5386	Cell surface protein
KM393_22670	COG5386	Cell surface protein
KM393_22675	COG1114	Component of the transport system for branched-chain amino acids
KM393_22680	COG1187	pseudouridine synthase activity
KM393_22690	COG1796	DNA polymerase
KM393_22690	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM393_22695	COG1286	toxin biosynthetic process
KM393_22740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM393_22750	COG1418	mRNA catabolic process
KM393_22775	COG2814	Major facilitator Superfamily
KM393_22780	COG1566	PFAM secretion protein HlyD family protein
KM393_22785	COG1309	transcriptional regulator
KM393_22790	COG1363	Peptidase, m42
KM393_22815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM393_22825	COG1484	DNA-dependent DNA replication
KM393_22830	COG3611	Membrane attachment protein
KM393_22840	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM393_22845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM393_22850	COG0237	dephospho-CoA kinase activity
KM393_22855	COG1971	Probably functions as a manganese efflux pump
KM393_22865	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM393_22865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM393_22870	COG5002	protein histidine kinase activity
KM393_22875	COG0745	RESPONSE REGULATOR receiver
KM393_22895	COG0538	isocitrate dehydrogenase activity
KM393_22900	COG0372	Belongs to the citrate synthase family
KM393_22910	COG0628	permease
KM393_22915	COG3030	protein affecting phage T7 exclusion by the F plasmid
KM393_22940	COG1725	Transcriptional regulator
KM393_22945	COG0281	malic enzyme
KM393_22950	COG0587	DNA-directed DNA polymerase activity
KM393_22965	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KM393_22985	COG4109	DRTGG domain
KM393_23000	COG0006	proline dipeptidase activity
KM393_23035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM393_23040	COG0662	Cupin 2, conserved barrel domain protein
KM393_23050	COG1476	TRANSCRIPTIONal
KM393_23065	COG1028	Short-chain dehydrogenase reductase Sdr
KM393_23070	COG0589	response to stress
KM393_23110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM393_23130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KM393_23135	COG0827	DNA restriction-modification system
KM393_23140	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KM393_23145	COG3874	Sporulation protein YtfJ
KM393_23160	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KM393_23170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM393_23185	COG1104	cysteine desulfurase activity
KM393_23195	COG0583	DNA-binding transcription factor activity
KM393_23200	COG0697	spore germination
KM393_23210	COG1956	GAF domain-containing protein
KM393_23215	COG0626	cystathionine gamma-synthase activity
KM393_23245	COG1595	DNA-templated transcription, initiation
KM393_23255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM393_23260	COG0454	-acetyltransferase
KM393_23265	COG0517	IMP dehydrogenase activity
KM393_23270	COG0123	including yeast histone deacetylase and acetoin utilization protein
KM393_23280	COG0745	RESPONSE REGULATOR receiver
KM393_23290	COG0666	response to abiotic stimulus
KM393_23325	COG1609	Transcriptional regulator
KM393_23330	COG4851	CamS sex pheromone cAM373 precursor
KM393_23335	COG3118	belongs to the thioredoxin family
KM393_23345	COG2309	aminopeptidase activity
KM393_23365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM393_23380	COG1674	ftsk spoiiie
KM393_23390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM393_23395	COG4848	Belongs to the UPF0354 family
KM393_23400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM393_23405	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
KM393_23410	COG1363	Peptidase, m42
KM393_23420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM393_23435	COG0510	thiamine kinase activity
KM393_23440	COG1523	belongs to the glycosyl hydrolase 13 family
KM393_23455	COG1349	DNA-binding transcription factor activity
KM393_23460	COG1187	pseudouridine synthase activity
KM393_23465	COG2244	polysaccharide biosynthetic process
KM393_23470	COG2081	HI0933 family
KM393_23475	COG2814	Major facilitator Superfamily
KM393_23485	COG3832	glyoxalase III activity
KM393_23505	COG1329	Transcriptional regulator
KM393_23515	COG4975	Glucose uptake
KM393_23530	COG0314	molybdopterin synthase activity
KM393_23535	COG1763	Mo-molybdopterin cofactor biosynthetic process
KM393_23540	COG0303	'Molybdopterin
KM393_23550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM393_23575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM393_23585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM393_23625	COG2814	Major facilitator Superfamily
KM393_23630	COG0475	glutathione-regulated potassium exporter activity
KM393_23635	COG0490	domain, Protein
KM393_23640	COG0582	viral genome integration into host DNA
KM393_23650	COG1136	(ABC) transporter
KM393_23670	COG1242	4 iron, 4 sulfur cluster binding
KM393_23675	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KM393_23680	COG1131	(ABC) transporter
KM393_23690	COG1794	racemase activity, acting on amino acids and derivatives
KM393_23710	COG2267	carboxylic ester hydrolase activity
KM393_23715	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KM393_23720	COG0671	phosphoesterase, PA-phosphatase related
KM393_23725	COG0438	transferase activity, transferring glycosyl groups
KM393_23735	COG0521	Mo-molybdopterin cofactor biosynthetic process
KM393_23790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM393_23795	COG3852	Histidine kinase
KM393_23800	COG4191	Histidine kinase
KM393_23805	COG2267	carboxylic ester hydrolase activity
KM393_23810	COG1368	sulfuric ester hydrolase activity
KM393_23825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM393_23830	COG1116	anion transmembrane transporter activity
KM393_23835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM393_23860	COG0494	nUDIX hydrolase
KM393_23890	COG0288	reversible hydration of carbon dioxide
KM393_23895	COG1271	oxidase subunit
KM393_23900	COG1294	oxidase, subunit
KM393_23920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM393_23945	COG1842	Phage shock protein A
KM393_23975	COG5002	protein histidine kinase activity
KM393_23980	COG0745	RESPONSE REGULATOR receiver
KM393_24010	COG1597	lipid kinase activity
KM393_24045	COG0586	Pfam SNARE associated Golgi protein
KM393_24055	COG0577	efflux transmembrane transporter activity
KM393_24060	COG1136	(ABC) transporter
KM393_24065	COG3708	Transcriptional regulator
KM393_24065	COG2207	Transcriptional regulator
KM393_24070	COG0745	RESPONSE REGULATOR receiver
KM393_24075	COG2205	protein histidine kinase activity
KM393_24080	COG0577	efflux transmembrane transporter activity
KM393_24090	COG0577	efflux transmembrane transporter activity
KM393_24095	COG1136	(ABC) transporter
KM393_24115	COG2188	Transcriptional regulator
KM393_24135	COG3964	amidohydrolase
KM393_24165	COG4948	Mandelate Racemase Muconate Lactonizing
KM393_24175	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KM393_24180	COG0596	Alpha beta hydrolase
KM393_24185	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KM393_24190	COG1169	isochorismate synthase
KM393_24195	COG1575	Belongs to the MenA family. Type 1 subfamily
KM393_24200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KM393_24220	COG0058	SHG alpha-glucan phosphorylase activity
KM393_24225	COG0297	glycogen (starch) synthase activity
KM393_24230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KM393_24350	COG0544	peptidyl-prolyl cis-trans isomerase activity
KM393_24385	COG1285	pathogenesis
KM393_24390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM393_24400	COG0166	Belongs to the GPI family
KM393_24405	COG2155	Conserved Protein
KM393_24410	COG1098	S1 RNA binding domain
KM393_24415	COG0436	Aminotransferase
KM393_24420	COG1522	sequence-specific DNA binding
KM393_24425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM393_24430	COG2267	carboxylic ester hydrolase activity
KM393_24440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KM393_24460	COG5018	Exonuclease
KM393_24465	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM393_24485	COG2050	protein possibly involved in aromatic compounds catabolism
KM393_24495	COG1268	BioY protein
KM393_24505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM393_24510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KM393_24525	COG3584	3D domain protein
KM393_24540	COG1252	NADH dehydrogenase
KM393_24555	COG3708	Transcriptional regulator
KM393_24570	COG1683	Conserved Protein
KM393_24590	COG0316	Belongs to the HesB IscA family
KM393_24605	COG1252	NADH dehydrogenase
KM393_24620	COG0390	transport system, permease component
KM393_24625	COG2824	Alkylphosphonate utilization operon protein PhnA
KM393_24665	COG4837	Protein of unknown function (DUF1462)
KM393_24670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KM393_24680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM393_24685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KM393_24695	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM393_24700	COG0647	UMP catabolic process
KM393_24710	COG2445	Protein of unknown function DUF86
KM393_24715	COG1494	fructose-1,6-bisphosphatase
KM393_24730	COG4470	Protein conserved in bacteria
KM393_24740	COG0789	Transcriptional regulator
KM393_24745	COG4377	Putative membrane peptidase family (DUF2324)
KM393_24770	COG0739	heme binding
KM393_24780	COG3377	Domain of unknown function (DUF1805)
KM393_24785	COG0737	Belongs to the 5'-nucleotidase family
KM393_24790	COG1695	Transcriptional regulator
KM393_24800	COG0719	Fe-S assembly protein
KM393_24805	COG0822	iron-sulfur transferase activity
KM393_24810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KM393_24815	COG0719	Fe-S assembly protein
KM393_24820	COG0396	ATPase activity
KM393_24825	COG1464	Belongs to the NlpA lipoprotein family
KM393_24830	COG1464	Belongs to the NlpA lipoprotein family
KM393_24835	COG2011	ABC-type metal ion transport system permease component
KM393_24840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM393_24850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM393_24855	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM393_24865	COG1393	Belongs to the ArsC family
KM393_24910	COG0039	L-malate dehydrogenase activity
KM393_24930	COG1309	transcriptional regulator
KM393_24935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM393_24940	COG1960	acyl-CoA dehydrogenase activity
KM393_24945	COG0183	Belongs to the thiolase family
KM393_24950	COG1024	Enoyl-CoA hydratase
KM393_24950	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM393_24960	COG1686	Belongs to the peptidase S11 family
KM393_24975	COG0011	TIGRFAM Protein of
KM393_24980	COG0840	transmembrane signaling receptor activity
KM393_25000	COG2814	Major facilitator Superfamily
KM393_25005	COG0531	amino acid
KM393_25015	COG0706	membrane insertase activity
KM393_25025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM393_25060	COG0586	Pfam SNARE associated Golgi protein
KM393_25070	COG1376	ErfK ybiS ycfS ynhG family protein
KM393_25075	COG0745	RESPONSE REGULATOR receiver
KM393_25080	COG5002	protein histidine kinase activity
KM393_25105	COG2151	metal-sulfur cluster biosynthetic enzyme
KM393_25110	COG3227	Zinc metalloprotease (Elastase)
KM393_25115	COG1741	Belongs to the pirin family
KM393_25130	COG0475	glutathione-regulated potassium exporter activity
KM393_25135	COG0490	domain, Protein
KM393_25140	COG1115	amino acid carrier protein
KM393_25145	COG0783	Belongs to the Dps family
KM393_25160	COG1611	Belongs to the LOG family
KM393_25180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM393_25185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM393_25190	COG1115	amino acid carrier protein
KM393_25195	COG1115	amino acid carrier protein
KM393_25200	COG2910	NAD(P)H-binding
KM393_25215	COG0656	L-ascorbic acid biosynthetic process
KM393_25220	COG2814	Major facilitator Superfamily
KM393_25225	COG1733	regulation of RNA biosynthetic process
KM393_25235	COG1252	NADH dehydrogenase
KM393_25240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KM393_25245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM393_25255	COG0840	transmembrane signaling receptor activity
KM393_25255	COG3290	protein histidine kinase activity
KM393_25265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM393_25270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM393_25285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM393_25340	COG0557	exoribonuclease II activity
KM393_25345	COG1647	Serine aminopeptidase, S33
KM393_25350	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM393_25355	COG1346	cytolysis
KM393_25455	COG4695	Portal protein
KM393_25480	COG4974	Belongs to the 'phage' integrase family
KM393_25490	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KM393_25495	COG0149	triose-phosphate isomerase activity
KM393_25505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM393_25520	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KM393_25545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM393_25560	COG2323	membrane
KM393_25565	COG0740	serine-type endopeptidase activity
KM393_25570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM393_25580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KM393_25590	COG1051	belongs to the nudix hydrolase family
KM393_25600	COG0492	ferredoxin-NADP+ reductase activity
KM393_25605	COG0457	Tetratricopeptide repeat
KM393_25610	COG0110	maltose O-acetyltransferase activity
KM393_25630	COG1950	PFAM Membrane protein of
KM393_25640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM393_25645	COG0556	nucleotide-excision repair
KM393_25665	COG0789	Transcriptional regulator
KM393_25690	COG2855	membrane
KM393_25695	COG0583	DNA-binding transcription factor activity
KM393_25705	COG0655	NAD(P)H dehydrogenase (quinone) activity
KM393_25710	COG0488	(ABC) transporter
KM393_25720	COG1132	(ABC) transporter
KM393_25725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM393_25730	COG3409	Peptidoglycan-binding domain 1 protein
KM393_25730	COG0793	Belongs to the peptidase S41A family
KM393_25735	COG2177	Part of the ABC transporter FtsEX involved in
KM393_25740	COG2884	Cell division ATP-binding protein ftsE
KM393_25755	COG0653	protein targeting
KM393_25760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KM393_25765	COG1278	Cold shock
KM393_25770	COG1040	competence protein
KM393_25775	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KM393_25780	COG1388	LysM domain
KM393_25780	COG0791	NLP P60 protein
KM393_25785	COG1733	regulation of RNA biosynthetic process
KM393_25790	COG1307	EDD domain protein, DegV family
KM393_25795	COG1739	Uncharacterized protein family UPF0029
KM393_25800	COG1316	TRANSCRIPTIONal
KM393_25805	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM393_25810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KM393_25815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KM393_25825	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KM393_25825	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KM393_25840	COG3394	polysaccharide catabolic process
KM393_25845	COG1486	melibiose metabolic process
KM393_25850	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM393_25855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM393_25865	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KM393_25870	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM393_25875	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM393_25885	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM393_25890	COG1301	dicarboxylic acid transport
KM393_25900	COG0346	lactoylglutathione lyase activity
KM393_25905	COG1511	domain protein
KM393_25910	COG0583	DNA-binding transcription factor activity
KM393_25915	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KM393_25930	COG1271	oxidase subunit
KM393_25935	COG1294	oxidase, subunit
KM393_25940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM393_25950	COG1620	l-lactate permease
KM393_25960	COG2389	metal-binding protein
KM393_25970	COG1368	sulfuric ester hydrolase activity
KM393_25985	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM393_25995	COG1215	transferase activity, transferring glycosyl groups
KM393_26000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM393_26005	COG3584	3D domain protein
KM393_26005	COG1388	LysM domain
KM393_26030	COG4715	Zinc finger, swim domain protein
KM393_26035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM393_26075	COG0577	efflux transmembrane transporter activity
KM393_26080	COG1136	(ABC) transporter
KM393_26120	COG0745	RESPONSE REGULATOR receiver
KM393_26125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM393_26140	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM393_26145	COG1134	teichoic acid transport
KM393_26150	COG1682	transport, permease protein
KM393_26155	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KM393_26200	COG1609	Transcriptional regulator
KM393_26215	COG0739	heme binding
KM393_26235	COG2385	sporulation resulting in formation of a cellular spore
KM393_26250	COG4836	Membrane
KM393_26255	COG1007	ATP synthesis coupled electron transport
KM393_26260	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM393_26265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM393_26275	COG0839	Belongs to the complex I subunit 6 family
KM393_26290	COG0649	NAD binding
KM393_26295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM393_26310	COG3300	MHYT domain
KM393_26310	COG5001	Diguanylate cyclase
KM393_26360	COG0356	it plays a direct role in the translocation of protons across the membrane
KM393_26395	COG0698	ribose 5-phosphate isomerase
KM393_26405	COG2190	(PTS) system
KM393_26410	COG2259	Doxx family
KM393_26415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KM393_26430	COG0009	L-threonylcarbamoyladenylate synthase
KM393_26445	COG2890	protein-(glutamine-N5) methyltransferase activity
KM393_26465	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KM393_26470	COG1494	fructose-1,6-bisphosphatase
KM393_26490	COG4821	SIS domain
KM393_26500	COG3343	RNA polymerase activity
KM393_26510	COG1960	acyl-CoA dehydrogenase activity
KM393_26515	COG1960	acyl-CoA dehydrogenase activity
KM393_26520	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM393_26525	COG0183	Belongs to the thiolase family
KM393_26530	COG0247	lactate metabolic process
KM393_26530	COG2181	nitrate reductase activity
KM393_26535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM393_26545	COG5001	Diguanylate cyclase
KM393_26545	COG3300	MHYT domain
KM393_26565	COG2197	response regulator
KM393_26570	COG4585	Histidine kinase
KM393_26575	COG0842	Transport permease protein
KM393_26580	COG1131	(ABC) transporter
KM393_26585	COG0024	Methionine aminopeptidase
KM393_26595	COG2234	aminopeptidase activity
KM393_26615	COG1595	DNA-templated transcription, initiation
KM393_26620	COG0018	arginyl-trna synthetase
KM393_26625	COG4506	Protein conserved in bacteria
KM393_26630	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM393_26645	COG0010	Belongs to the arginase family
KM393_26655	COG2814	Major facilitator Superfamily
KM393_26660	COG0789	Transcriptional regulator
KM393_26665	COG0584	glycerophosphoryl diester phosphodiesterase
KM393_26670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM393_26680	COG1994	Peptidase M50
KM393_26690	COG1078	dGTPase activity
KM393_26695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM393_26700	COG1120	ATPase activity
KM393_26705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM393_26730	COG0095	Lipoate-protein ligase
KM393_26735	COG0280	phosphate acetyltransferase
KM393_26750	COG3773	Cell wall hydrolase
KM393_26760	COG2363	Small membrane protein
KM393_26770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM393_26775	COG2233	PERMEase
KM393_26780	COG0561	phosphatase activity
KM393_26785	COG2814	Major facilitator Superfamily
KM393_26795	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM393_26800	COG1131	(ABC) transporter
KM393_26805	COG2755	lipolytic protein G-D-S-L family
KM393_26810	COG1609	Transcriptional regulator
KM393_26820	COG0460	homoserine dehydrogenase
KM393_26830	COG2873	o-acetylhomoserine
KM393_26840	COG1011	Hydrolase
KM393_26845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM393_26855	COG2197	response regulator
KM393_26865	COG0351	phosphomethylpyrimidine kinase
KM393_26870	COG3706	GGDEF domain
KM393_26875	COG2879	small protein
KM393_26880	COG1966	Carbon starvation protein
KM393_26885	COG3279	Response regulator of the LytR AlgR family
KM393_26890	COG0477	Major facilitator Superfamily
KM393_26915	COG0840	transmembrane signaling receptor activity
KM393_26925	COG1607	acyl-coa hydrolase
KM393_26940	COG0488	(ABC) transporter
KM393_26960	COG0463	Glycosyl transferase, family 2
KM393_26965	COG1309	transcriptional regulator
KM393_26970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM393_26975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM393_26975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM393_26980	COG0628	permease
KM393_26995	COG3279	Response regulator of the LytR AlgR family
KM393_27000	COG3275	phosphorelay sensor kinase activity
KM393_27005	COG2814	Major facilitator Superfamily
KM393_27010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM393_27015	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KM393_27020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM393_27040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM393_27045	COG1272	protein, Hemolysin III
KM393_27065	COG0516	GMP reductase activity
KM393_27070	COG1164	Oligoendopeptidase f
KM393_27090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM393_27095	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KM393_27100	COG4853	Protein conserved in bacteria
KM393_27105	COG4863	YycH protein
KM393_27110	COG5002	protein histidine kinase activity
KM393_27115	COG0745	RESPONSE REGULATOR receiver
KM393_27145	COG0305	Participates in initiation and elongation during chromosome replication
KM393_27155	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KM393_27160	COG4241	membrane
KM393_27170	COG0629	single-stranded DNA binding
KM393_27180	COG0012	GTP binding
KM393_27185	COG4481	Protein conserved in bacteria
KM393_27190	COG0668	transmembrane transport
KM393_27200	COG1475	DNA binding
KM393_27205	COG1192	Involved in chromosome partitioning
KM393_27230	COG1847	R3H domain protein
KM393_27235	COG0706	membrane insertase activity
KM393_27245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KM393_27405	COG0791	NLP P60 protein
KM393_27405	COG0741	lytic transglycosylase activity
KM393_27470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM393_27525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM393_27535	COG4166	transmembrane transport
KM393_27575	COG1280	lysine exporter protein (LysE YggA)
KM393_27600	COG0681	Belongs to the peptidase S26 family
KM393_27675	COG1309	transcriptional regulator
KM393_27680	COG1683	Conserved Protein
KM393_27720	COG1192	Involved in chromosome partitioning