locus-tag class description BF26_10 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF26_1002 ENOG4108JJ8 (ABC) transporter BF26_1003 ENOG4108JJ9 ABC, transporter BF26_1004 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF26_1005 ENOG4105C4M (Ubiquinol oxidase) subunit I BF26_1007 ENOG4105YGB Transcriptional regulator BF26_101 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BF26_1011 ENOG4105SKE transcriptional Regulator LysR family BF26_1013 ENOG4105C32 Amino acid ABC transporter (Permease) BF26_1014 ENOG4108IV0 ABC, transporter BF26_1015 ENOG4105C0Z ABC transporter BF26_1017 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF26_1018 ENOG4108Z7G MaoC domain protein dehydratase BF26_102 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BF26_1022 ENOG4105CKI cobalamin synthesis protein BF26_1024 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF26_1025 ENOG4106F5Q Membrane BF26_1026 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF26_1028 ENOG4108TVJ Nitroreductase BF26_1029 ENOG4107ZXU DSBA oxidoreductase BF26_103 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BF26_1030 ENOG4108Z40 Transcriptional regulator BF26_1031 ENOG4105GZI Transcriptional regulator BF26_1032 ENOG4107RT3 EamA-like transporter family BF26_1034 ENOG4105KTB nuclear export factor GLE1 BF26_1035 ENOG4108T5E Copper resistance protein BF26_1045 ENOG4107STQ Multicopper oxidase BF26_1046 ENOG4107RAQ aminopeptidase BF26_105 ENOG4105C02 permease BF26_1052 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BF26_1053 ENOG4105D9N nucleoside BF26_1055 ENOG4107RHR regulatoR BF26_1060 ENOG4105C0X amino acid BF26_1061 ENOG4105C0X amino acid BF26_1063 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BF26_1065 ENOG4105C72 UPF0176 protein BF26_1066 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BF26_1071 ENOG41068WN BF26_1077 ENOG4108J59 Extracellular solute-binding protein, family 5 BF26_1078 ENOG4105F6J Alpha beta hydrolase fold BF26_1082 ENOG4105CYC Transferase BF26_1083 ENOG4105DY9 regulatoR BF26_1085 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BF26_1086 ENOG4105C6X Major Facilitator BF26_1091 ENOG4105C7B Threonine dehydratase BF26_1093 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF26_1094 ENOG4108ZP8 Acetolactate synthase small subunit BF26_1095 ENOG4105C7K acetolactate synthase BF26_1096 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF26_1097 ENOG4105CHR reductase BF26_1098 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF26_1102 ENOG4106KE4 Dehydrogenase BF26_1105 ENOG4105H67 Protein of unknown function (DUF421) BF26_1106 ENOG4105X5K response regulator receiver protein BF26_1108 ENOG4105C8J )-transporter BF26_1112 ENOG4105C6T cysteine synthase BF26_1113 ENOG4105EU0 Major facilitator Superfamily BF26_1116 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF26_1119 ENOG4105DXI Major Facilitator superfamily BF26_1120 ENOG4105DXI Major Facilitator superfamily BF26_1121 ENOG4105CSR polyphosphate kinase 2 BF26_1129 ENOG4105FVX BF26_114 ENOG4105DVE abc transporter atp-binding protein BF26_1142 ENOG4105C6K Malic enzyme BF26_1143 ENOG4108IJ0 Aspartate ammonia-lyase BF26_1145 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BF26_1149 ENOG4105CJ1 ABC, transporter BF26_1157 ENOG4106BRA Membrane BF26_1164 ENOG4107QIV Cytochrome c biogenesis protein BF26_1169 ENOG4105EC3 peptidase S51, dipeptidase E BF26_1170 ENOG4107QJQ Mate efflux family protein BF26_1171 ENOG4107QJQ Mate efflux family protein BF26_1175 ENOG4105C9Q fumarate hydratase class II BF26_1176 ENOG4105DFD Na H antiporter BF26_1179 ENOG4108PJD permease BF26_1180 ENOG4105CKI cobalamin synthesis protein BF26_1181 ENOG4108UZ3 Transporter BF26_1182 ENOG4105DRR Transcriptional regulator, GntR family BF26_1184 ENOG4105PGM cation diffusion facilitator family transporter BF26_1188 ENOG4105CAQ asparagine synthetase BF26_1195 ENOG4105CVJ phosphoglycerate mutase BF26_1202 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BF26_1203 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BF26_1204 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF26_1205 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF26_1206 ENOG4105DUM transcriptional regulator, lysR family BF26_121 ENOG4105CHM Aminotransferase BF26_1212 ENOG4105KAC Antibiotic biosynthesis monooxygenase BF26_1216 ENOG4108RZE Tetr family transcriptional regulator BF26_1221 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF26_1222 ENOG4105KTQ flagellar basal-body rod protein BF26_1223 ENOG4105FZW flagellar biosynthesis regulator FlhF BF26_1224 ENOG4105D7B Flagellar biosynthesis protein flha BF26_1225 ENOG4105D00 flagellar biosynthetic protein flhB BF26_1227 ENOG4105VS8 Flagellar biosynthetic protein fliq BF26_1228 ENOG4105CN7 Flagellar biosynthetic protein FliP BF26_1230 ENOG4105DD5 Flagellar motor switch protein BF26_1232 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF26_1233 ENOG4105E4C Lytic transglycosylase catalytic BF26_1234 ENOG4105I03 Flagellin BF26_1239 ENOG4107TVC Glycosyl transferase, family 2 BF26_1245 ENOG4105K64 Glycosyl transferase, family 2 BF26_1247 ENOG4107R88 Chemotaxis protein (CheV) BF26_1251 ENOG4105BZE flagellar hook protein, FlgE BF26_1258 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF26_1260 ENOG4107U2N Flagellar M-ring protein BF26_1261 ENOG41075Z6 flagellar hook-basal body complex protein fliE BF26_1262 ENOG4108ZC9 flagellar basal-body rod protein flgc BF26_1263 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BF26_1268 ENOG4105DTJ flagellar hook-associated protein BF26_1269 ENOG4105E1Q flagellar hook-associated protein BF26_127 ENOG41089UC methyltransferase, type 11 BF26_1273 ENOG4105BZU Histidine kinase BF26_1276 ENOG4105DD5 Flagellar motor switch protein BF26_1277 ENOG4105CBS Chea signal transduction histidine kinase BF26_1278 ENOG4105CBS Chea signal transduction histidine kinase BF26_1279 ENOG4107YTP response regulator receiver protein BF26_1280 ENOG4105ER2 Ompa motb domain protein BF26_1281 ENOG4107R0U MotA TolQ exbB proton channel BF26_1283 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF26_1294 ENOG41080C8 DUF218 domain BF26_1295 ENOG4105H67 Protein of unknown function (DUF421) BF26_1297 ENOG4108Z5V transcriptional regulator, merr family BF26_1298 ENOG4105CN5 Metallo-Beta-Lactamase BF26_1299 ENOG4107RWR Sodium hydrogen exchanger BF26_130 ENOG4107BMA Transglycosylase associated protein BF26_1301 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF26_1314 ENOG41081VK Ribonuclease BF26_1318 ENOG4108SZE gCN5-related N-acetyltransferase BF26_1321 ENOG4105CPK Glycosyl transferase (Group 1 BF26_1335 ENOG4106032 Glutathionylspermidine synthase BF26_1338 ENOG4105KHC sulfurtransferase BF26_134 ENOG4106K7D Major facilitator family transporter BF26_1340 ENOG4108W0I acetyltransferase BF26_1342 ENOG410890F Dynamin family BF26_1344 ENOG4105DHF Membrane BF26_1345 ENOG4105C2W permease BF26_1347 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF26_135 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF26_1350 ENOG4105CTD carboxy-peptidase BF26_1351 ENOG4105DVT helicase BF26_1353 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BF26_1365 ENOG4105BZ4 penicillin-binding protein BF26_1367 ENOG4105CSM endonuclease III BF26_1371 ENOG4105YAC BF26_1372 ENOG4105DVT helicase BF26_1379 ENOG4105CPK Glycosyl transferase (Group 1 BF26_1380 ENOG4105FJR Lmbe family BF26_1383 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BF26_1384 ENOG4108JYZ YitT family BF26_1390 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BF26_1391 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BF26_1392 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BF26_1395 ENOG41068YB TPR repeat-containing protein BF26_1396 ENOG4105CIH Imidazole acetol-phosphate transaminase BF26_1400 ENOG4105EAH synthase BF26_1402 ENOG4105XXQ heptaprenyl diphosphate synthase component I BF26_1405 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BF26_1411 ENOG41065D1 BF26_1412 ENOG4105S2F BF26_1420 ENOG4107RB3 L-asparaginase BF26_1421 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BF26_1426 ENOG4108S6Z Negative regulator of genetic competence BF26_1427 ENOG4107X2D transcriptional regulator, merr family BF26_1428 ENOG4107RGJ metallophosphoesterase BF26_143 ENOG4105EPR degv family BF26_1430 ENOG4105I7S Abortive infection protein BF26_1431 ENOG4105C9U ATP-dependent DNA helicase RecQ BF26_1432 ENOG4105T7X BF26_1434 ENOG4108SAX Membrane BF26_1437 ENOG4108WBT adenosyltransferase BF26_1438 ENOG4105BZU Histidine kinase BF26_1439 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF26_1440 ENOG4105CRE cytochrome C BF26_1441 ENOG4107TWT Cytochrome c biogenesis protein BF26_1443 ENOG4105FE9 pseudouridine synthase BF26_1445 ENOG4108JIC nucleoside recognition domain protein BF26_1446 ENOG4105DZ1 carboxypeptidase BF26_1447 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF26_1454 ENOG4105BZU Histidine kinase BF26_1457 ENOG4105I3N Conserved Protein BF26_1458 ENOG4105BZU Histidine kinase BF26_146 ENOG4105DPN Oligoendopeptidase f BF26_1461 ENOG4105BZ4 penicillin-binding protein BF26_1462 ENOG4107GRR phosphate transport regulator BF26_1463 ENOG4105CJ3 phosphate transporter BF26_1467 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BF26_1472 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BF26_1476 ENOG4105WH1 Two component transcriptional regulator luxr family BF26_1477 ENOG4105ENE Histidine kinase BF26_1481 ENOG4105DFD Na H antiporter BF26_1485 ENOG4105C8J )-transporter BF26_1486 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF26_1487 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF26_1488 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF26_1490 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BF26_1491 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BF26_1495 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BF26_1497 ENOG4105E0M Sulfatase BF26_1498 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF26_15 ENOG41068WN BF26_1501 ENOG4107RVV histidinol phosphate phosphatase, hisj family BF26_1508 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BF26_1513 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BF26_1515 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF26_1516 ENOG4108ZP8 Acetolactate synthase small subunit BF26_1517 ENOG4105C7K acetolactate synthase BF26_1518 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF26_1523 ENOG4105KBJ sporulation protein ytfj BF26_1524 ENOG41063Y9 BF26_1525 ENOG4105CZN Potassium uptake protein BF26_153 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF26_1531 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF26_1532 ENOG4107QMU Mate efflux family protein BF26_1539 ENOG4105NQC Flavodoxin BF26_154 ENOG4105BZU Histidine kinase BF26_1544 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF26_1546 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF26_1547 ENOG4105EA8 2-Nitropropane dioxygenase BF26_1548 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF26_155 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BF26_1556 ENOG4105CJ1 ABC, transporter BF26_1558 ENOG4105CZV ABC transporter BF26_1559 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF26_1560 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF26_1561 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF26_1563 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF26_1564 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BF26_1572 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BF26_1573 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BF26_1575 ENOG4105BZU Histidine kinase BF26_1577 ENOG4106DF1 BF26_1579 ENOG41090MY MarR family Transcriptional regulator BF26_1580 ENOG4105BZU Histidine kinase BF26_1582 ENOG4105PXI polysaccharide deacetylase BF26_1584 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF26_1585 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF26_1590 ENOG4105E98 transcriptional regulator DeoR family BF26_1593 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BF26_1594 ENOG4107RCV ABC transporter, permease BF26_1597 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF26_1599 ENOG4105C4Y ABC transporter BF26_1603 ENOG4105MWK D-amino acid dehydrogenase, small subunit BF26_1605 ENOG4105CHR reductase BF26_1609 ENOG4108Z7G MaoC domain protein dehydratase BF26_1610 ENOG410681C small acid-soluble spore protein BF26_1611 ENOG4105CZN Potassium uptake protein BF26_1612 ENOG4107TS3 membrane protein, TerC BF26_1613 ENOG4108QTI )-transporter BF26_1615 ENOG4106A3R peptidase BF26_1619 ENOG4105JXH GntR family transcriptional regulator BF26_1620 ENOG4105BZU Histidine kinase BF26_1621 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF26_1624 ENOG4105CQB FAD linked oxidase domain protein BF26_1625 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF26_1626 ENOG4105K4I Scp-like extracellular BF26_1628 ENOG4108YBP pseudouridine synthase BF26_163 ENOG4105DTQ mandelate racemase muconate lactonizing BF26_1630 ENOG4105EYF MMPL domain protein BF26_1632 ENOG4107RUE extracellular solute-binding protein family 1 BF26_1633 ENOG4105D38 putrescine abc transporter BF26_1634 ENOG4105F38 ABC transporter, permease BF26_1635 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF26_1636 ENOG4105C26 Dehydrogenase BF26_1642 ENOG4105VFR signal peptidase BF26_1643 ENOG4105DZ1 carboxypeptidase BF26_1645 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BF26_1656 ENOG4105VZ8 Transcriptional regulator BF26_1658 ENOG4105C7S Dehydrogenase BF26_166 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BF26_167 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF26_1676 ENOG4105DDQ anthranilate synthase BF26_1677 ENOG4105CRQ synthase (Component I) BF26_1678 ENOG4105CK7 Sodium proline symporter BF26_1683 ENOG4108WVJ 2'-5' rna ligase BF26_1692 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BF26_1694 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BF26_1695 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BF26_17 ENOG4108WCX response regulator BF26_170 ENOG4107T5V SNARE associated Golgi BF26_1700 ENOG4107TVC Glycosyl transferase, family 2 BF26_1704 ENOG4105K64 Glycosyl transferase, family 2 BF26_1706 ENOG4105CNI cell division protein FtsW BF26_1710 ENOG4105EMS pseudouridine synthase BF26_1711 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BF26_1714 ENOG4105MIX Adenylate cyclase BF26_1715 ENOG4108Z18 K06886 hemoglobin BF26_1718 ENOG4105DPN Oligoendopeptidase f BF26_1720 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF26_1722 ENOG4108ZCF integral membrane protein BF26_1726 ENOG4105UQX Mate efflux family protein BF26_1727 ENOG4108JQ7 (ABC) transporter BF26_1729 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF26_1730 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF26_1733 ENOG4105C31 Tryptophanyl-tRNA synthetase BF26_1736 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF26_1737 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF26_1742 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BF26_1744 ENOG4108KP7 hydrolase BF26_1746 ENOG41073B9 BF26_1747 ENOG4107AYK membrAne BF26_1749 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF26_1751 ENOG4105QNR S1 RNA binding domain protein BF26_1755 ENOG4105BZU Histidine kinase BF26_1756 ENOG4105CH6 catalase BF26_1757 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BF26_1758 ENOG4105CAQ asparagine synthetase BF26_1763 ENOG4105ERH Fumarylacetoacetate hydrolase BF26_177 ENOG41080HI glycine oxidase BF26_1771 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BF26_1772 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BF26_1775 ENOG4105XVF Competence transcription factor BF26_1778 ENOG4105VEQ Cold shock protein BF26_178 ENOG4105CTU Proline racemase BF26_1781 ENOG4107QP3 malate synthase g BF26_1782 ENOG4105ZU5 s-layer protein BF26_1786 ENOG4105C8Q Methyl-accepting chemotaxis BF26_1787 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BF26_179 ENOG4105CTU Proline racemase BF26_1793 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF26_1797 ENOG41086D8 Transcriptional regulator BF26_1798 ENOG4108AEY RNA polymerase sigma factor BF26_180 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF26_1800 ENOG4107TVP HD domain protein BF26_1801 ENOG4107RN3 metallophosphoesterase BF26_1803 ENOG4105ENX hydrolase BF26_1808 ENOG4105CNA YD repeat protein BF26_181 ENOG4105C26 Dehydrogenase BF26_1815 ENOG4105CEY Amp-dependent synthetase and ligase BF26_1817 ENOG4105DF9 Lipoate-protein, ligase BF26_1818 ENOG4108RQ5 Beta-lactamase domain-containing protein BF26_1819 ENOG4106AXD BF26_182 ENOG4105BZG amino acid carrier protein BF26_1829 ENOG4105NA0 Transcriptional regulator BF26_1834 ENOG4105C1Q protoporphyrinogen oxidase BF26_1836 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BF26_1837 ENOG4105BZ4 penicillin-binding protein BF26_1838 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BF26_1839 ENOG4105CKV Membrane BF26_1840 ENOG410905X membrane-flanked domain protein BF26_1849 ENOG4105CKV Membrane BF26_185 ENOG4108M1A Chitin-binding protein BF26_1851 ENOG410905X membrane-flanked domain protein BF26_1858 ENOG4105K59 histidine triad (HIT) protein BF26_1863 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF26_1864 ENOG4105EEM helicase BF26_1866 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF26_1867 ENOG4105C57 major facilitator superfamily BF26_1872 ENOG4105EMN RNA polymerase sigma factor BF26_1875 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BF26_1878 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF26_1883 ENOG4108MUZ hydrolase BF26_1889 ENOG4105EQ0 Major Facilitator superfamily BF26_1890 ENOG4108IND Tetr family transcriptional regulator BF26_1893 ENOG4105D7V transposase BF26_1894 ENOG4106D4I domain protein BF26_1895 ENOG4107VRP DNA repair exonuclease BF26_19 ENOG41090T1 Membrane BF26_1901 ENOG4105K8R UPF0145 protein BF26_1906 ENOG4105BZU Histidine kinase BF26_1907 ENOG4105BZU Histidine kinase BF26_1908 ENOG4108MJI response regulator BF26_1910 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF26_1912 ENOG4105WN5 stage II sporulation protein BF26_1925 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BF26_193 ENOG4105C9U ATP-dependent DNA helicase RecQ BF26_1930 ENOG410847I Transcriptional regulator, BadM Rrf2 family BF26_1931 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF26_1932 ENOG4105CMT Dihydroxyacetone kinase BF26_1934 ENOG4105CMT Dihydroxyacetone kinase BF26_1938 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF26_1942 ENOG4108IG5 Transcriptional regulator BF26_1943 ENOG4107P5I polyketide synthase BF26_1953 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF26_1961 ENOG4105CDU Replicative dna helicase BF26_197 ENOG4105EEM helicase BF26_1970 ENOG4108MRH transcriptional regulatory protein BF26_1972 ENOG4105CSH Transporter BF26_1978 ENOG4105PKS Excinuclease abc c subunit domain protein BF26_1979 ENOG4108JQ7 (ABC) transporter BF26_1982 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF26_1990 ENOG4105CTU Proline racemase BF26_1994 ENOG4105DER m42 family BF26_1997 ENOG4105CGU Enoyl-CoA hydratase BF26_2000 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF26_2001 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF26_2003 ENOG4106AKK s-layer domain-containing protein BF26_2011 ENOG4105CHH sulfate transporter BF26_2014 ENOG4105D4P Coproporphyrinogen iii oxidase BF26_2016 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF26_2021 ENOG4107FQX Alpha-acetolactate decarboxylase BF26_2028 ENOG410839P BF26_2031 ENOG4105CDA abc transporter atp-binding protein BF26_2032 ENOG4105DRP amino acid AbC transporter BF26_2034 ENOG4105BZ1 (ABC) transporter BF26_2035 ENOG4105BZ1 (ABC) transporter BF26_2036 ENOG4105BZ1 (ABC) transporter BF26_2037 ENOG4105C26 Dehydrogenase BF26_2039 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BF26_2040 ENOG4105D5Q Arginine ornithine antiporter BF26_2042 ENOG4105CH6 catalase BF26_2043 ENOG4107RKG DJ-1/PfpI family BF26_2045 ENOG4105E5W Transporter BF26_2046 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF26_2047 ENOG4105NF4 modulator of drug activity BF26_2052 ENOG4105KPY Small multidrug resistance protein BF26_2053 ENOG4105KPY Small multidrug resistance protein BF26_2055 ENOG4108YXU transcriptional regulator AsnC family BF26_2056 ENOG4108PCN EamA-like transporter family BF26_2063 ENOG4106KNT transcriptional regulator BF26_2065 ENOG4107RWR Sodium hydrogen exchanger BF26_2066 ENOG4105CUB amino acid BF26_2072 ENOG4107T5V SNARE associated Golgi BF26_2079 ENOG4105WEF catalase BF26_208 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF26_2085 ENOG4105C19 ABC transporter BF26_2086 ENOG4107RBB ABC transporter, permease BF26_2087 ENOG41069ER domain protein BF26_2091 ENOG4105VZJ PTS System BF26_2092 ENOG4105VCP PTS System BF26_2093 ENOG4105EMD TRANSCRIPTIONal BF26_2098 ENOG4108KGH TRANSCRIPTIONal BF26_2100 ENOG41087NI Sulfite exporter TauE/SafE BF26_2101 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BF26_2103 ENOG41085GJ domain protein BF26_2105 ENOG4105VFE sira family BF26_2106 ENOG4107TPS domain protein BF26_2107 ENOG4105VFE sira family BF26_2108 ENOG4105XTG Pfam:DUF156 BF26_2109 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BF26_2114 ENOG4105ED1 spovr family BF26_2115 ENOG4107Y03 Nitroreductase BF26_2121 ENOG4108B31 Spore germination protein BF26_2128 ENOG4105C5Y PTS System BF26_2135 ENOG4105C7N Xanthine uracil vitamin C permease BF26_2138 ENOG4108INS Transcriptional regulator BF26_2146 ENOG4105DWF phosphomethylpyrimidine kinase BF26_2147 ENOG4105D06 uba thif-type nad fad binding protein BF26_2150 ENOG41080HI glycine oxidase BF26_2151 ENOG4108VEU Thiamine monophosphate synthase BF26_2153 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF26_2155 ENOG4105ETU transcriptional activator (TenA BF26_2159 ENOG41080XQ Signal transduction protein with cbs domains BF26_217 ENOG4108M1A Chitin-binding protein BF26_218 ENOG41082BV acetyltransferase BF26_2186 ENOG4105E2Z phosphate ABC transporter (Permease BF26_2187 ENOG4105C8U phosphate abc transporter BF26_2188 ENOG4105CVA phosphate BF26_2189 ENOG4105CE1 Ferrous iron transport protein b BF26_219 ENOG4105E66 phosphoriboisomerase A BF26_2190 ENOG4105CE1 Ferrous iron transport protein b BF26_2191 ENOG4105CE1 Ferrous iron transport protein b BF26_2192 ENOG4108NHD germination protein BF26_2195 ENOG4105E1V na solute symporter BF26_2196 ENOG4106CAD Protein of unknown function (DUF3311) BF26_2199 ENOG4105E2S oxidase) subunit II BF26_22 ENOG4105VMP Transcriptional regulator BF26_2200 ENOG4105BZ9 Cytochrome C oxidase, subunit I BF26_2208 ENOG4105C7N Xanthine uracil vitamin C permease BF26_2209 ENOG4105C85 amino acid BF26_2213 ENOG4105DUX Transporter BF26_2215 ENOG4107D63 BF26_2216 ENOG4105VZ8 Transcriptional regulator BF26_2217 ENOG41069ER domain protein BF26_2218 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF26_2219 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF26_2231 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF26_2232 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BF26_2233 ENOG4105CNN ABC, transporter BF26_2234 ENOG4105C2J ABC transporter BF26_2236 ENOG4108RVA ribokinase BF26_2237 ENOG4105ETE Transcriptional regulator (LacI family BF26_2238 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF26_2239 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF26_224 ENOG4108IJ7 Glycine betaine BF26_2240 ENOG41067TZ transcriptional regulator, MarR family BF26_2241 ENOG4105CXY transporter BF26_2243 ENOG4108JQ7 (ABC) transporter BF26_2244 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF26_2249 ENOG41068KF Universal stress protein BF26_225 ENOG4107SQ8 Glycine betaine BF26_2250 ENOG4105CHH sulfate transporter BF26_2253 ENOG4105BZU Histidine kinase BF26_2254 ENOG4105NAE bifunctional deaminase-reductase domain protein BF26_2255 ENOG4105D29 Helix-turn-helix type 11 domain protein BF26_2260 ENOG4108IQI permease BF26_2261 ENOG4105DRP amino acid AbC transporter BF26_2262 ENOG4105EAD ABC transporter BF26_2263 ENOG4105CT1 (ABC) transporter BF26_2264 ENOG4105CDA abc transporter atp-binding protein BF26_2265 ENOG4105BZG amino acid carrier protein BF26_2266 ENOG4105CRN Aminoglycoside phosphotransferase BF26_2268 ENOG4105E1K spore germination protein BF26_2271 ENOG4105CG3 alpha amylase, catalytic region BF26_2272 ENOG4105C5Y PTS System BF26_2273 ENOG4107414 GntR family transcriptional regulator BF26_2274 ENOG4105D5Q Arginine ornithine antiporter BF26_2275 ENOG4105BZU Histidine kinase BF26_2278 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF26_2279 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BF26_2280 ENOG4107T89 von Willebrand factor, type A BF26_2282 ENOG4105EXW epimerase dehydratase BF26_2284 ENOG4105DMQ Methyltransferase BF26_2285 ENOG4105E0A ABC, transporter BF26_2286 ENOG4108IHU transport system permease protein BF26_2287 ENOG4105DQ5 transport system permease protein BF26_2288 ENOG4108MES Periplasmic binding protein BF26_2289 ENOG4105DUX Transporter BF26_2292 ENOG4105DAA L-lactate BF26_2293 ENOG4108IJ0 Aspartate ammonia-lyase BF26_2294 ENOG4105C37 (CBS) domain BF26_2295 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BF26_2296 ENOG4105D9N nucleoside BF26_2297 ENOG4108KGH TRANSCRIPTIONal BF26_2298 ENOG41073R8 VanW family BF26_2306 ENOG4105DAP Nicotinate phosphoribosyltransferase BF26_2307 ENOG4105C59 p-type ATPase BF26_2309 ENOG4105CUB amino acid BF26_231 ENOG4105RHY Pfam:UPF0157 BF26_2314 ENOG4108JB9 formate dehydrogenase BF26_2315 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF26_2316 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF26_2318 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF26_2319 ENOG4105BZU Histidine kinase BF26_232 ENOG4105E1F short-chain dehydrogenase reductase BF26_2321 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF26_2322 ENOG4108UZ3 Transporter BF26_2324 ENOG4105C6K Malic enzyme BF26_2326 ENOG4108MRH transcriptional regulatory protein BF26_2331 ENOG4105US7 Histidine kinase BF26_2332 ENOG4108STX response regulator BF26_2333 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BF26_2334 ENOG4105BZ7 extracellular solute-binding protein family 1 BF26_2335 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BF26_2336 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BF26_2337 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF26_2338 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF26_234 ENOG4107RUY (E1 component), alpha subunit BF26_2342 ENOG4105D4T Citrate transporter BF26_2343 ENOG4108MRH transcriptional regulatory protein BF26_2344 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BF26_2346 ENOG4105DZ6 Band 7 protein BF26_2349 ENOG4105C94 Transporter BF26_2353 ENOG4105CYN Serine protein kinase BF26_2355 ENOG4105BZU Histidine kinase BF26_2356 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BF26_2358 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BF26_236 ENOG4107QKR Dehydrogenase BF26_2360 ENOG4107ZQN disulfide bond BF26_2361 ENOG4108JQC penicillin-binding protein 1A BF26_2386 ENOG4105G5W regulator Fur family BF26_2387 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF26_2391 ENOG4108IUW ABC transporter BF26_2393 ENOG4105CBC glutamate synthase BF26_2394 ENOG4107NBY Membrane BF26_2395 ENOG4105BZ1 (ABC) transporter BF26_2399 ENOG4106BXE BF26_24 ENOG4105G6Z alkaline phosphatase BF26_2400 ENOG4105CEN a g-specific adenine glycosylase BF26_2401 ENOG41067AE Membrane-bound metal-dependent hydrolase BF26_2407 ENOG4105ECP epimerase BF26_2408 ENOG4105CI2 imidazolone-5-propionate hydrolase BF26_241 ENOG41062ES Transcriptional regulator BF26_2412 ENOG4105F1A Pyruvate formate-lyase BF26_2415 ENOG4105C3I Nad-dependent epimerase dehydratase BF26_2416 ENOG4107QQG Dehydrogenase BF26_2418 ENOG4105CKK Glycosyl transferase, family 2 BF26_2421 ENOG4108A04 Beta-lactamase BF26_2423 ENOG4105CSV Glutaminase BF26_2429 ENOG4108IQI permease BF26_2431 ENOG4108JUB Transcriptional regulator BF26_2433 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF26_245 ENOG4105E98 transcriptional regulator DeoR family BF26_249 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BF26_2491 ENOG4105VTR Integrase BF26_2492 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF26_25 ENOG4105ECK Fatty Acid Desaturase BF26_2500 ENOG4105UPD Calcium Proton BF26_2501 ENOG410606W general stress protein BF26_2504 ENOG4107ZTW SNARE associated Golgi BF26_2507 ENOG4105C3F Signal peptidase i BF26_2509 ENOG4108IPJ Membrane BF26_2510 ENOG4105C59 p-type ATPase BF26_2511 ENOG4107U9T Pfam:Ribonuclease_BN BF26_2513 ENOG4105KJF protein tyrosine phosphatase BF26_2517 ENOG4108TTB tellurium resistance protein BF26_2518 ENOG4107TS3 membrane protein, TerC BF26_2519 ENOG4106FN3 tellurium resistance protein BF26_2520 ENOG4106FN3 tellurium resistance protein BF26_2521 ENOG4108N0M stress protein BF26_2524 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BF26_2527 ENOG4105DEU major facilitator superfamily BF26_2531 ENOG41062JF Transcriptional regulator BF26_2536 ENOG4105C5H ABC transporter BF26_2539 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF26_2542 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BF26_2548 ENOG4105CI1 PTS System BF26_255 ENOG4107Z3H Transcriptional regulator, TetR family BF26_2550 ENOG4105C8Q Methyl-accepting chemotaxis BF26_2551 ENOG4105C8Q Methyl-accepting chemotaxis BF26_2553 ENOG4105EAB amino acid AbC transporter BF26_2554 ENOG4105E5Q amino acid AbC transporter BF26_2557 ENOG4105D2S major facilitator superfamily BF26_2558 ENOG410756H nucleotidyltransferase BF26_256 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BF26_2562 ENOG4105BZU Histidine kinase BF26_2566 ENOG4106UIA BF26_2567 ENOG4106UIA BF26_257 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BF26_2571 ENOG4108V5C ABC transporter BF26_2572 ENOG4105DQ5 transport system permease protein BF26_2573 ENOG4105EHG Permease protein BF26_2574 ENOG4107W7X Aldolase BF26_2576 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BF26_2577 ENOG4105D3R alkyl hydroperoxide reductase BF26_258 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BF26_2582 ENOG4105DFD Na H antiporter BF26_2583 ENOG4105DTQ mandelate racemase muconate lactonizing BF26_2586 ENOG4108W15 Protein of unknown function (DUF1456) BF26_2589 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF26_2590 ENOG4105D9N nucleoside BF26_2594 ENOG4105KPY Small multidrug resistance protein BF26_2595 ENOG4105C26 Dehydrogenase BF26_2597 ENOG4108JPW Aminotransferase BF26_2598 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BF26_2599 ENOG4105CBD Diacylglycerol kinase BF26_26 ENOG4105E0Y RtcB Protein BF26_2604 ENOG410834F Transcriptional regulator BF26_2605 ENOG4105D0U Arsenite-activated ATPase (ArsA) BF26_2609 ENOG4105D01 (LipO)protein BF26_2610 ENOG4108UMI ABC transporter, permease BF26_2611 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF26_2612 ENOG4108W2Y isochorismatase BF26_2618 ENOG4105C4R Atp-dependent dna helicase BF26_262 ENOG4105MSI germination protein ypeb BF26_2623 ENOG4105C12 Phosphoribosylglycinamide synthetase BF26_2625 ENOG4108V3E phosphoribosylglycinamide formyltransferase BF26_2630 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BF26_2632 ENOG4105C83 adenylosuccinate lyase BF26_2633 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BF26_2634 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BF26_2639 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF26_2643 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF26_2648 ENOG4108SHN Glycosyl transferase, family 2 BF26_2654 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF26_266 ENOG4108V3A UPF0421 protein BF26_2662 ENOG4105BZU Histidine kinase BF26_2664 ENOG4105C7N Xanthine uracil vitamin C permease BF26_2668 ENOG4108TYN CAAX amino terminal protease family protein BF26_2671 ENOG4105C5H ABC transporter BF26_2672 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF26_2673 ENOG410801F ribosomal-protein-alanine acetyltransferase BF26_2674 ENOG41072GX Peptidase M22 Glycoprotease BF26_2675 ENOG4105K8N protein family UPF0079, ATPase BF26_2695 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BF26_2697 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF26_2698 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BF26_2701 ENOG4107ZXI Rhomboid family BF26_2703 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF26_2704 ENOG4105CPF Cell wall formation (By similarity) BF26_2705 ENOG4105CPF Cell wall formation (By similarity) BF26_2706 ENOG4108SC4 )-transporter BF26_2708 ENOG4105ERH Fumarylacetoacetate hydrolase BF26_2709 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BF26_2718 ENOG410667J hydrolase BF26_2719 ENOG4108JQ7 (ABC) transporter BF26_2720 ENOG4105C3U ABC transporter BF26_2721 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF26_2723 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BF26_2726 ENOG4105C5H ABC transporter BF26_273 ENOG4105FDR Membrane BF26_2730 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BF26_2731 ENOG4108RE7 deoxyribonuclease BF26_2734 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF26_2738 ENOG4105F6E Acyl-transferase BF26_2742 ENOG4105EGI Transcriptional regulator BF26_2745 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BF26_2746 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF26_2747 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF26_2748 ENOG4105E0C molybdate abc transporter BF26_275 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF26_2750 ENOG4107XDY Nicotinamide Mononucleotide Transporter BF26_2751 ENOG4105II7 pyrroline-5-carboxylate reductase BF26_2753 ENOG4108J59 Extracellular solute-binding protein, family 5 BF26_2754 ENOG4108J59 Extracellular solute-binding protein, family 5 BF26_2760 ENOG4108JQ7 (ABC) transporter BF26_2761 ENOG4105C3U ABC transporter BF26_2762 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF26_2763 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF26_2766 ENOG4105C2C drug resistance transporter, Bcr CflA BF26_2769 ENOG4105IQ5 FAD linked oxidase domain protein BF26_2771 ENOG4105EE1 crotonyl-CoA reductase BF26_2772 ENOG4105D01 (LipO)protein BF26_2773 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF26_2774 ENOG4108UMI ABC transporter, permease BF26_2775 ENOG4108PSK reductase BF26_2783 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BF26_2784 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BF26_2786 ENOG4105CMG Carbohydrate kinase BF26_2787 ENOG4105CMG Carbohydrate kinase BF26_2789 ENOG4108VQT Alpha beta hydrolase fold protein BF26_2790 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BF26_2792 ENOG4107U5W ybbr family BF26_2793 ENOG4105C8B TIGR00159 family BF26_28 ENOG4107258 Transcriptional regulator BF26_280 ENOG4108IUM Glycogen debranching enzyme BF26_2811 ENOG4108NMV polysaccharide deacetylase BF26_2814 ENOG4105D1F ATP-binding protein BF26_2819 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF26_2820 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF26_2821 ENOG4108JJB ABC transporter BF26_2827 ENOG41067V7 50S ribosomal protein L36 BF26_2829 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF26_283 ENOG4105DY8 decarboxylase BF26_2831 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF26_2836 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BF26_2857 ENOG4105XPM ribosomal protein BF26_2858 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BF26_2860 ENOG4107Y49 methyltransferase BF26_2865 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BF26_2867 ENOG4105QIV RNA polymerase BF26_2868 ENOG4105M0M Tetracycline resistance protein BF26_2869 ENOG4105C2N RNA methyltransferase TrmH family group 3 BF26_2872 ENOG4105D7W serine acetyltransferase BF26_2876 ENOG4105CTP PilT protein domain protein BF26_2878 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BF26_288 ENOG4105PAD Hydrolase BF26_2881 ENOG4108Z0C Uvrb UvrC protein BF26_2888 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BF26_2890 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BF26_2891 ENOG4105KRF dihydroneopterin aldolase BF26_2892 ENOG4105EEI dihydropteroate synthase BF26_2893 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BF26_2894 ENOG4105DDQ anthranilate synthase BF26_2895 ENOG4105CRQ synthase (Component I) BF26_2896 ENOG4105C6T cysteine synthase BF26_2899 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BF26_2900 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF26_2901 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BF26_2905 ENOG41060GV RNA binding s1 domain protein BF26_2908 ENOG4105VYY sporulation protein yabp BF26_2909 ENOG41082I2 s4 domain protein BF26_2910 ENOG4108IY2 MazG family BF26_2912 ENOG4108M14 stage v sporulation protein t BF26_2913 ENOG4108JA2 transcriptioN-repair coupling factor BF26_2915 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BF26_2916 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BF26_2919 ENOG4105KME endoribonuclease L-psp BF26_2920 ENOG4105DFT pur operon repressor BF26_2923 ENOG4105W42 Veg protein BF26_2924 ENOG4105XFA sporulation peptidase YabG BF26_2926 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BF26_2927 ENOG4105F8V Hydrolase, tatD family BF26_2929 ENOG4105KRN Transcriptional regulator, abrb family BF26_293 ENOG4107VFR oxidoreductase BF26_2930 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BF26_2932 ENOG41060K3 Methyltransferase BF26_2934 ENOG4105MA4 psp1 domain protein BF26_2935 ENOG4105FA2 dna polymerase iii BF26_2937 ENOG4105CXN decarboxylase BF26_2945 ENOG41067KS pro-sigma K processing BF26_2949 ENOG4105C6E dna polymerase iii BF26_2950 ENOG4108Z6B deaminase BF26_2951 ENOG4105GTG Isochorismatase BF26_2953 ENOG4105ZMH deoxynucleoside kinase BF26_2960 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF26_2968 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF26_2971 ENOG410848D S4 domain protein YaaA BF26_2972 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF26_2976 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF26_2978 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BF26_2982 ENOG4107QJE Chromosome Partitioning Protein BF26_2983 ENOG4105FA0 parb-like partition protein BF26_2984 ENOG4108ZDA Sporulation protein YyaC BF26_2985 ENOG4105D8X mechanosensitive ion channel BF26_2986 ENOG4105VDK protein, conserved in bacteria BF26_2987 ENOG4105C3G gtp-binding protein BF26_2989 ENOG4108UUM single-stranded DNA-binding protein BF26_2991 ENOG4108XMW Membrane BF26_2992 ENOG4105BZR domain protein BF26_2994 ENOG4105CDU Replicative dna helicase BF26_30 ENOG4105II7 pyrroline-5-carboxylate reductase BF26_3000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF26_3001 ENOG4105BZU Histidine kinase BF26_3004 ENOG4105Q2H domain protein BF26_3005 ENOG4105C0H protease BF26_3009 ENOG4105DPN Oligoendopeptidase f BF26_3012 ENOG4105C1J atp-dependent rna helicase BF26_3014 ENOG4108UT2 hemolysin iii BF26_3015 ENOG4105CMR udp-glucose 4-epimerase BF26_3017 ENOG4105IW1 AmiS UreI transporter BF26_3019 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF26_302 ENOG4105PKS Excinuclease abc c subunit domain protein BF26_3022 ENOG4107RGD Major Facilitator superfamily BF26_3023 ENOG4108HRK Histidine kinase BF26_3024 ENOG4105DY9 regulatoR BF26_3027 ENOG4106F5Q Membrane BF26_3028 ENOG4105E0X reductase BF26_3030 ENOG41067SE Tetr family transcriptional regulator BF26_3031 ENOG4105CKK Glycosyl transferase, family 2 BF26_3036 ENOG4105C5H ABC transporter BF26_3037 ENOG4105JEU Glycosyl transferase, family 2 BF26_3039 ENOG4108S4H thioesterase Superfamily protein BF26_3041 ENOG4106YBV Methyl-accepting chemotaxis BF26_3042 ENOG4105EN6 Membrane BF26_3046 ENOG41079KZ Major Facilitator Superfamily BF26_3047 ENOG4105DY9 regulatoR BF26_3048 ENOG4105D22 carbon starvation protein BF26_3049 ENOG4105VCD cytoplasmic protein BF26_3050 ENOG4105BZU Histidine kinase BF26_3051 ENOG4105DWF phosphomethylpyrimidine kinase BF26_3052 ENOG4105BZU Histidine kinase BF26_3053 ENOG4105BZU Histidine kinase BF26_3054 ENOG4105WH1 Two component transcriptional regulator luxr family BF26_3056 ENOG4108Y4K DNA-binding transcriptional activator BF26_3061 ENOG4105D6E homoserine dehydrogenase BF26_3066 ENOG4105CJ1 ABC, transporter BF26_3067 ENOG4108TU7 Inherit from COG: (ABC) transporter BF26_3069 ENOG4105VCH membrane BF26_3070 ENOG410667J hydrolase BF26_3072 ENOG4107SVH Potassium channel protein BF26_3076 ENOG4108VKI Cell wall hydrolase BF26_3079 ENOG4108IJ2 phosphate acetyltransferase BF26_3082 ENOG4108VCI transcription factor, rsfa family BF26_3084 ENOG4105DQ5 transport system permease protein BF26_3085 ENOG4105DQ5 transport system permease protein BF26_3086 ENOG4105EHG Permease protein BF26_3087 ENOG4105E0A ABC, transporter BF26_3088 ENOG4108MES Periplasmic binding protein BF26_3089 ENOG4105DCI Phosphohydrolase BF26_309 ENOG4105KWG Pfam:DUF1696 BF26_3090 ENOG41069HH 4-oxalocrotonate tautomerase BF26_3091 ENOG4108Z4T Peptidase M50 BF26_3092 ENOG4108XFG YwhD family BF26_3093 ENOG4105BZ4 penicillin-binding protein BF26_3094 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF26_3095 ENOG4107SWG transcriptional regulator MERR family BF26_3096 ENOG4105DXB Major Facilitator superfamily BF26_3098 ENOG4105CYW agmatinase BF26_31 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BF26_310 ENOG4108NRW Phospholipase, patatin family BF26_3102 ENOG410684U Domain of unknown function (DUF1934) BF26_3104 ENOG4105EMN RNA polymerase sigma factor BF26_3108 ENOG4105IIU Aminopeptidase BF26_3112 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BF26_3113 ENOG4108M15 ABC transporter BF26_3114 ENOG4105KCT ABC transporter BF26_3115 ENOG4105BZU Histidine kinase BF26_3120 ENOG4105BZU Histidine kinase BF26_3123 ENOG4105DF6 Fe-S oxidoreductase BF26_3125 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF26_3126 ENOG4105C1G acyl-Coa dehydrogenase BF26_3127 ENOG4105C1G acyl-Coa dehydrogenase BF26_3134 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BF26_3135 ENOG4105CBT Fructose-1,6-bisphosphatase BF26_3136 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BF26_3139 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BF26_3140 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF26_3141 ENOG4108ZXQ stage ii sporulation protein r BF26_3143 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF26_3146 ENOG4107XC4 flavin reductase domain protein, FMN-binding BF26_3147 ENOG4108VGI doxx family BF26_3150 ENOG4108YZG isomerase BF26_3155 ENOG41062M3 atp synthase BF26_3156 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BF26_316 ENOG4108XI2 Domain of unknown function (DUF1963) BF26_3166 ENOG4105BZU Histidine kinase BF26_3167 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF26_3169 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF26_3170 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF26_3175 ENOG4105D65 subunit l BF26_3176 ENOG4105C8S subunit m BF26_3177 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF26_3178 ENOG4106778 Protein of unknown function (DUF1146) BF26_3182 ENOG4108IUW ABC transporter BF26_3183 ENOG4105DY9 regulatoR BF26_3186 ENOG4105FRN stage II sporulation protein BF26_3188 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BF26_3198 ENOG4105EY8 ABC transporter BF26_3199 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF26_3202 ENOG4105CMR udp-glucose 4-epimerase BF26_3203 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF26_3207 ENOG4105CXY transporter BF26_3211 ENOG4105C19 ABC transporter BF26_3215 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF26_3221 ENOG4105C0D helicase BF26_3222 ENOG4105KBK Zinc finger, swim domain protein BF26_3227 ENOG41069ER domain protein BF26_3228 ENOG4105C94 Transporter BF26_323 ENOG4108Z4K mutator MutT protein BF26_3230 ENOG4107R8N Glycosyl transferase, family 2 BF26_3236 ENOG4105E0M Sulfatase BF26_3239 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BF26_324 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF26_3241 ENOG4105DAA L-lactate BF26_325 ENOG4105E09 nadh pyrophosphatase BF26_3250 ENOG4107RSM transcriptional regulator BF26_3251 ENOG4105ECB domain protein BF26_3252 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BF26_3255 ENOG4105VZJ PTS System BF26_3257 ENOG4105VCP PTS System BF26_3258 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF26_3259 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BF26_3261 ENOG4105CK1 PTS System BF26_3262 ENOG4105VCP PTS System BF26_3263 ENOG4105F8D glycoside hydrolase family 4 BF26_3264 ENOG410901P UPF0249 protein BF26_3267 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BF26_3269 ENOG4105ESV Glycosyl transferase, family 4 BF26_327 ENOG4105FCD Major Facilitator BF26_3270 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF26_3271 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF26_3272 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF26_3273 ENOG4108KGH TRANSCRIPTIONal BF26_3274 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BF26_3276 ENOG4105KVH Transcriptional regulator BF26_3279 ENOG41081UC Inherit from COG: Competence protein BF26_3280 ENOG4105VEQ Cold shock protein BF26_3281 ENOG4105MS2 ribosomal subunit Interface protein BF26_3282 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BF26_3283 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BF26_3285 ENOG4105CAK Cell division ATP-binding protein ftsE BF26_3286 ENOG4105CRP Part of the ABC transporter FtsEX involved in BF26_3287 ENOG4105CN1 protease BF26_3289 ENOG4105BZ1 (ABC) transporter BF26_3292 ENOG4108WS4 fmn reductase BF26_3294 ENOG4105DUM transcriptional regulator, lysR family BF26_3295 ENOG4105HMI Membrane BF26_3299 ENOG4107TXC Transcriptional regulator BF26_3302 ENOG4105D7V transposase BF26_3303 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BF26_3304 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF26_3306 ENOG41086DT Membrane protein of unknown function BF26_3310 ENOG4108S4C acetyltransferase BF26_3312 ENOG4105C3M thioredoxin reductase BF26_3314 ENOG4108Z4K mutator MutT protein BF26_3316 ENOG4105CHW UPF0052 protein BF26_3318 ENOG4105KRI phosphocarrier protein (HPr BF26_3319 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF26_3320 ENOG4105H67 Protein of unknown function (DUF421) BF26_3323 ENOG4105CZ3 stage V sporulation protein ad BF26_3324 ENOG41090VF Stage v sporulation protein ac BF26_3328 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF26_3333 ENOG4105CP7 Triose-phosphate isomerase BF26_3334 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BF26_3336 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF26_334 ENOG4107Y9U Membrane BF26_3341 ENOG4105EFC phage portal protein HK97 family BF26_3362 ENOG41067MG lrgb family BF26_3363 ENOG4105XZU Preprotein translocase, subunit SecG BF26_3365 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BF26_3370 ENOG4105CM4 permease protein BF26_3371 ENOG4108IPW abc transporter atp-binding protein BF26_3374 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BF26_3375 ENOG4108MK9 spermidine N(1)-acetyltransferase BF26_3378 ENOG4105WMR Protein CrcB homolog BF26_3379 ENOG4105WMR Protein CrcB homolog BF26_3381 ENOG4105C8Q Methyl-accepting chemotaxis BF26_3383 ENOG4105D4A Cell wall formation (By similarity) BF26_3384 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF26_3387 ENOG4105KVH Transcriptional regulator BF26_3388 ENOG4105F27 Major Facilitator BF26_3389 ENOG4105CV8 reductase BF26_339 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF26_3394 ENOG4108RYK Nad-dependent epimerase dehydratase BF26_3397 ENOG4105D9N nucleoside BF26_3398 ENOG4105D9N nucleoside BF26_3401 ENOG41090A1 ferritin BF26_3403 ENOG4108URH decarboxylase BF26_3406 ENOG4108RMU ferritin dps family protein BF26_3408 ENOG4105NCW Trka-c domain protein BF26_3409 ENOG4107S91 Sodium hydrogen exchanger BF26_3413 ENOG4105D4Y metalloprotease BF26_3414 ENOG4105VG1 fes assembly suf system protein BF26_3417 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BF26_3419 ENOG4105BZU Histidine kinase BF26_3420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF26_3421 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF26_3423 ENOG4107ZTW SNARE associated Golgi BF26_343 ENOG4107Y80 Major Facilitator superfamily BF26_3430 ENOG4107AYK membrAne BF26_3432 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF26_3434 ENOG4107R7I amino acid BF26_3435 ENOG4108SUT Major Facilitator Superfamily BF26_3439 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF26_3443 ENOG4105DZ1 carboxypeptidase BF26_3446 ENOG4105CHU acetyl-coa acetyltransferase BF26_3447 ENOG4105C1G acyl-Coa dehydrogenase BF26_3448 ENOG4108W8B Beta-lactamase domain protein BF26_3454 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF26_3463 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF26_3469 ENOG4108UMI ABC transporter, permease BF26_3470 ENOG4105D01 (LipO)protein BF26_3471 ENOG4105D01 (LipO)protein BF26_3472 ENOG4105C3K feS assembly ATPase SufC BF26_3473 ENOG4105JRK feS assembly protein SufD BF26_3474 ENOG4105C9B Cysteine desulfurase BF26_3475 ENOG4108UNV SUF system FeS assembly protein, NifU family BF26_3476 ENOG4105DIW FeS assembly protein SUFB BF26_3479 ENOG4107R8B 5'-nucleotidase BF26_348 ENOG4108V4B ThiJ pfpI BF26_3480 ENOG4105KZD Domain of unknown function (DUF1805) BF26_3482 ENOG4105FAA peptidase M23 BF26_3487 ENOG41090T1 Membrane BF26_3488 ENOG4107TXC Transcriptional regulator BF26_3489 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BF26_3490 ENOG4105MMD transcriptional regulator BF26_3493 ENOG4105CBT Fructose-1,6-bisphosphatase BF26_3496 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF26_3497 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF26_3499 ENOG4108W5N phosphatidylglycerophosphatase a BF26_3502 ENOG41083MR nifu domain-containing protein BF26_3511 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BF26_3512 ENOG4105C4B ABC transporter, permease BF26_3513 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF26_3517 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BF26_3520 ENOG4105EWC Purine nucleoside phosphorylase BF26_3526 ENOG4105CEP NADH dehydrogenase BF26_3529 ENOG41069ER domain protein BF26_3533 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF26_3537 ENOG4105KA0 thioesterase Superfamily protein BF26_3538 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BF26_354 ENOG4105FQP Beta-lactamase BF26_3541 ENOG4107R3E Citrate transporter BF26_3543 ENOG4105Y38 Kinase-associated protein B BF26_3546 ENOG4105C87 Aminotransferase class I and II BF26_3548 ENOG4108MUZ hydrolase BF26_3549 ENOG4105C5I Dehydrogenase BF26_3550 ENOG4108ZB6 transcriptional regulator AsnC family BF26_3551 ENOG4105CHM Aminotransferase BF26_3553 ENOG4105WG9 Conserved Protein BF26_3554 ENOG4107QYV phosphohexose isomerase BF26_3555 ENOG4107PBV potassium channel BF26_3557 ENOG4105KT7 mgtC SapB transporter BF26_356 ENOG4105CJN penicillin-binding protein BF26_3565 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BF26_357 ENOG4105CB2 alcohol dehydrogenase BF26_3584 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF26_3586 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BF26_3588 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BF26_3593 ENOG4105VEQ Cold shock protein BF26_3595 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF26_3596 ENOG4105E4F Isochorismate synthase BF26_3597 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BF26_3598 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BF26_3599 ENOG4108IPT Naphthoate synthase BF26_360 ENOG4108HGU Histidine kinase BF26_3601 ENOG4105DTQ mandelate racemase muconate lactonizing BF26_3608 ENOG41069H0 dihydroorotase EC 3.5.2.3 BF26_3612 ENOG4105FDP GntR family transcriptional regulator BF26_3613 ENOG4105C6Z Gluconate BF26_3624 ENOG41086D8 Transcriptional regulator BF26_3625 ENOG4105C19 ABC transporter BF26_3628 ENOG4107ZTW SNARE associated Golgi BF26_363 ENOG4108JJB ABC transporter BF26_3635 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BF26_3636 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF26_3641 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF26_3642 ENOG4105BZU Histidine kinase BF26_3649 ENOG41087YS Phage shock protein A BF26_3658 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF26_3659 ENOG4105C4M (Ubiquinol oxidase) subunit I BF26_3661 ENOG4108V2W Carbonate dehydratase BF26_3668 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF26_367 ENOG4107RF6 penicillin-binding protein BF26_3672 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BF26_3674 ENOG4105D2X ABC transporter substrate-binding protein BF26_3677 ENOG4107T7U Sulfatase BF26_3678 ENOG4107S9D Alpha beta hydrolase BF26_3679 ENOG4105BZU Histidine kinase BF26_368 ENOG4105BZU Histidine kinase BF26_3680 ENOG4105BZU Histidine kinase BF26_3681 ENOG4105EGD dinuclear metal center protein, YbgI family BF26_3691 ENOG4108RIR Molybdenum cofactor biosynthesis protein BF26_3693 ENOG4105BZF Glycosyl transferase (Group 1 BF26_3694 ENOG4105YVM Phosphoesterase, PA-phosphatase related BF26_3695 ENOG4108Z0R Transferase BF26_3696 ENOG4105E8V Alpha Beta Hydrolase Fold protein BF26_370 ENOG410667J hydrolase BF26_3702 ENOG4105DA5 (ABC) transporter BF26_3704 ENOG4105N5T Radical SAM Protein BF26_3708 ENOG4105C19 ABC transporter BF26_3711 ENOG4105NCW Trka-c domain protein BF26_3712 ENOG4107S91 Sodium hydrogen exchanger BF26_3713 ENOG410605W Major Facilitator BF26_3720 ENOG4108B31 Spore germination protein BF26_3722 ENOG4105DWV Homoserine O-trans-acetylase BF26_3724 ENOG41085GJ domain protein BF26_3728 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF26_3729 ENOG4105D06 uba thif-type nad fad binding protein BF26_3731 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF26_3732 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BF26_3733 ENOG4108ZAF Molybdopterin BF26_3736 ENOG4105CSC Glucose uptake protein BF26_3737 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BF26_3738 ENOG4108VJ1 Transcriptional regulator (CarD family BF26_3745 ENOG4105CBX hi0933 family BF26_3748 ENOG4105YW5 deoR family transcriptional regulator BF26_3749 ENOG4107QSE Dipeptidase BF26_3750 ENOG4107QSE Dipeptidase BF26_3752 ENOG4108IUM Glycogen debranching enzyme BF26_3753 ENOG4108V15 phosphotransferase enzyme family BF26_3756 ENOG4105C8F Beta-lactamase domain protein BF26_3762 ENOG4108VDD TRNA binding domain protein BF26_3771 ENOG4105C88 aminopeptidase BF26_3775 ENOG4105ETE Transcriptional regulator (LacI family BF26_3781 ENOG4105EP9 oxidoreductase BF26_3782 ENOG4107SNB ankyrin repeat protein YahD BF26_3784 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF26_3786 ENOG4105DGU Histone deacetylase BF26_3787 ENOG4105W87 Cbs domain BF26_3788 ENOG4105F1V Acetoin utilization protein BF26_3791 ENOG4105EMN RNA polymerase sigma factor BF26_3793 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF26_3797 ENOG4105C28 cystathionine BF26_3799 ENOG4105U5Y Transcriptional regulator BF26_38 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BF26_3800 ENOG4105U5Y Transcriptional regulator BF26_3802 ENOG4106KR7 LysR family Transcriptional regulator BF26_3807 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF26_3809 ENOG4105EFZ amidohydrolase BF26_3812 ENOG4105KBJ sporulation protein ytfj BF26_3813 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BF26_3815 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BF26_3819 ENOG4108JYZ YitT family BF26_3828 ENOG4107YZX Universal stress protein BF26_3832 ENOG4105VZ8 Transcriptional regulator BF26_3834 ENOG41082W1 Cupin 2, conserved barrel domain protein BF26_3835 ENOG4105Z7P Acetyltransferase (GNAT) family BF26_3842 ENOG4105DC7 peptidase M24 BF26_3849 ENOG4105SFS phosphoesterase RecJ domain protein BF26_3851 ENOG4105VV2 BF26_3852 ENOG4105C0B DNA polymerase III (alpha subunit) BF26_3853 ENOG4105C6K Malic enzyme BF26_3854 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF26_3859 ENOG4105FS0 cytoplasmic membrane protein BF26_3860 ENOG4108REF Sporulation integral membrane protein ytvi BF26_3862 ENOG4105BZN citrate synthase BF26_3863 ENOG4108HMX isocitrate dehydrogenase (NADP) BF26_3867 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF26_3868 ENOG4105BZU Histidine kinase BF26_3869 ENOG4105C2M dna polymerase I BF26_3870 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BF26_3872 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BF26_3873 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BF26_3874 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF26_3878 ENOG4108TDW sporulation protein YtxC BF26_3879 ENOG4105C22 threonyL-tRNA synthetase BF26_3880 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BF26_3884 ENOG4105CN9 Peptidase m42 family protein BF26_3885 ENOG4108JGH Tetr family transcriptional regulator BF26_3886 ENOG4105CW7 secretion protein, HlyD family BF26_3887 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF26_3894 ENOG4108RWN rrna methyltransferase BF26_3896 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BF26_3897 ENOG4105C5S asparaginyl-tRNA synthetase BF26_3904 ENOG4105DCG PHP domain protein BF26_3907 ENOG4105FE9 pseudouridine synthase BF26_3909 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BF26_3911 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BF26_3914 ENOG4105E0A ABC, transporter BF26_3915 ENOG4105KFN sortase, SrtB family BF26_3918 ENOG4105DR4 Methyltransferase BF26_3921 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF26_393 ENOG4105ETU transcriptional activator (TenA BF26_3930 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF26_3931 ENOG4105J76 Periplasmic binding protein BF26_3933 ENOG4105CEY Amp-dependent synthetase and ligase BF26_3934 ENOG4107Z3H Transcriptional regulator, TetR family BF26_3935 ENOG41060WC Enoyl-CoA hydratase BF26_3936 ENOG4105BZJ Electron transfer flavoprotein BF26_3937 ENOG4105C10 Electron transfer flavoprotein BF26_3938 ENOG4105K63 Thioredoxin BF26_3941 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BF26_3943 ENOG4105E33 succinate dehydrogenase BF26_3945 ENOG4108VXD carboxy-peptidase BF26_3946 ENOG4105E14 MotA TolQ exbB proton channel BF26_3947 ENOG4105ER2 Ompa motb domain protein BF26_3948 ENOG4105ER2 Ompa motb domain protein BF26_3949 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BF26_3950 ENOG4108IUX (ABC) transporter BF26_3951 ENOG4105RHA ABC transporter, permease BF26_3952 ENOG4108Z40 Transcriptional regulator BF26_3953 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BF26_3955 ENOG4108JCI Transcriptional regulator BF26_3956 ENOG41067S9 phage shock protein C, PspC BF26_3959 ENOG4105DY9 regulatoR BF26_3960 ENOG4108HRK Histidine kinase BF26_3961 ENOG4108JQ7 (ABC) transporter BF26_3964 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF26_3965 ENOG4105DEF Extracellular solute-binding protein, family 5 BF26_3966 ENOG4105DZC cytosine deaminase BF26_3967 ENOG4105DZC cytosine deaminase BF26_3971 ENOG4105PFC Transcriptional regulator BF26_3974 ENOG4105KBX Transcriptional regulator, TetR family BF26_3976 ENOG4108PCX Major Facilitator BF26_3978 ENOG4108XJQ germination protein BF26_3980 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BF26_3981 ENOG4105M59 Phosphodiesterase, mj0936 family BF26_3985 ENOG4108QCI YvbH-like oligomerisation region BF26_3991 ENOG4108IUQ atp-dependent protease BF26_3995 ENOG4105K56 Transcriptional regulator BF26_4000 ENOG4105D52 delta-aminolevulinic acid dehydratase BF26_4002 ENOG41068KH stage VI sporulation protein D BF26_4004 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BF26_4005 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BF26_4009 ENOG4105DFF Rod shape-determining protein mreb BF26_4010 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BF26_4013 ENOG4107QMS site-determining protein BF26_4016 ENOG4105C03 ribonuclease BF26_4018 ENOG4105X36 (ribosomal) protein BF26_4021 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BF26_4024 ENOG4105EWM Histidine kinase BF26_4028 ENOG4105CQC Prephenate dehydratase BF26_4029 ENOG4108RPX mosc domain containing protein BF26_4032 ENOG4108IYU L-aspartate oxidase BF26_4033 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BF26_4038 ENOG41082BM Transcriptional regulator, arsr family BF26_4039 ENOG4108IPJ Membrane BF26_4040 ENOG4108IPJ Membrane BF26_4042 ENOG4108HUF Transporter BF26_4045 ENOG41061AI Protein of unknown function (DUF2905) BF26_4048 ENOG4105VIE preprotein translocase, subunit YajC BF26_4050 ENOG4108QG2 Membrane BF26_4051 ENOG4105CKP Polysaccharide Biosynthesis Protein BF26_4053 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BF26_4054 ENOG41076HS cation diffusion facilitator family transporter BF26_4055 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF26_4057 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF26_4060 ENOG4105CUT histidyl-tRNA synthetase BF26_4062 ENOG4105CUZ uba thif-type nad fad binding protein BF26_4063 ENOG4108VCI transcription factor, rsfa family BF26_4064 ENOG4105D1H recombination factor protein RarA BF26_4066 ENOG4105C3J Cysteine desulfurase BF26_4067 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BF26_4069 ENOG4105C7H Helicase, RecD TraA family BF26_4070 ENOG41060CR BF26_4073 ENOG4105C02 permease BF26_4075 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF26_4079 ENOG4105HHA aminodeoxychorismate lyase BF26_4080 ENOG4108VQJ O-methyltransferase BF26_4081 ENOG4105XYU peptidase (U32 family) BF26_4082 ENOG4105CFP Peptidase U32 BF26_4085 ENOG4107XRG penicillin-binding protein BF26_4091 ENOG4105C28 cystathionine BF26_4092 ENOG4108EKI Dehydrogenase BF26_4094 ENOG4108V5C ABC transporter BF26_4095 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF26_4103 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF26_4104 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF26_4106 ENOG4105MIR Phenylalanine 4-monooxygenase BF26_4107 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF26_4114 ENOG4108MUZ hydrolase BF26_4116 ENOG4105G6Z alkaline phosphatase BF26_4119 ENOG4108TVJ Nitroreductase BF26_4124 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF26_4127 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF26_4128 ENOG4105CQW ribosome biogenesis GTPase YqeH BF26_4130 ENOG410812S Rna-binding protein BF26_4132 ENOG4108WF2 Metal Dependent Phosphohydrolase BF26_4134 ENOG4105DXX methyltransferase BF26_4136 ENOG4105KQC Competence protein BF26_4137 ENOG4108UK2 deaminase BF26_4138 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF26_414 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF26_4140 ENOG4105TQK DNA polymerase iii, delta' subunit BF26_4145 ENOG4105KVH Transcriptional regulator BF26_4146 ENOG4105CSA Coproporphyrinogen iii oxidase BF26_4148 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BF26_415 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF26_4152 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BF26_4153 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF26_4155 ENOG4105KTH gatB Yqey BF26_4156 ENOG41068P3 sporulation protein YqfC BF26_4158 ENOG4105C9A Phoh family BF26_4159 ENOG4105CTJ Metal Dependent Phosphohydrolase BF26_4161 ENOG4107YR5 Diacylglycerol kinase BF26_4162 ENOG4105KG3 cytidine deaminase BF26_4163 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BF26_4168 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BF26_4169 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF26_4172 ENOG4105EGD dinuclear metal center protein, YbgI family BF26_4177 ENOG41069ZM Protein of unknown function (DUF2624) BF26_4178 ENOG4108JYZ YitT family BF26_4179 ENOG4105FDK ABC transporter BF26_418 ENOG4105CPQ Dehydrogenase BF26_4181 ENOG4105N80 Ferric uptake regulator, Fur family BF26_4186 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF26_4188 ENOG4107RF6 penicillin-binding protein BF26_4189 ENOG4105PWN phosphate abc transporter BF26_4190 ENOG4105C8U phosphate abc transporter BF26_4191 ENOG4105E2Z phosphate ABC transporter (Permease BF26_4192 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BF26_4193 ENOG4108UTW Plays a role in the regulation of phosphate uptake BF26_4196 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BF26_4198 ENOG4105DKQ ROK family BF26_42 ENOG41061GT Aldolase BF26_4200 ENOG4105C5X domain protein BF26_4204 ENOG4105C28 cystathionine BF26_4205 ENOG4105C28 cystathionine BF26_4207 ENOG4105C3R Methionine synthase BF26_4208 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF26_4232 ENOG4105C0D helicase BF26_4238 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF26_4239 ENOG4105CJ1 ABC, transporter BF26_424 ENOG4105CUV Homoserine Kinase BF26_4246 ENOG41080TC multidrug resistance protein BF26_4250 ENOG4105WZW rhodanese family BF26_4251 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BF26_4255 ENOG4107YBY Hydrolase BF26_4257 ENOG4105CBJ Metal-dependent enzyme BF26_4260 ENOG4105DC7 peptidase M24 BF26_4265 ENOG4105CD2 stage iii sporulation protein aa BF26_4266 ENOG4105KR5 Stage iii sporulation protein BF26_4267 ENOG4108CQH stage III sporulation protein AC BF26_4268 ENOG4105KQ4 Stage iii sporulation protein ad BF26_4270 ENOG410644B Stage III sporulation protein af BF26_4275 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF26_4276 ENOG4108ZSR alkaline shock protein BF26_428 ENOG4107Y80 Major Facilitator superfamily BF26_4281 ENOG4105CTB Polyprenyl synthetase BF26_4283 ENOG4105DX0 Hemolysin A BF26_4285 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BF26_4286 ENOG4105S1Z Stage IV sporulation protein B BF26_4287 ENOG4107QQR Sporulation BF26_4290 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF26_4292 ENOG4108JUB Transcriptional regulator BF26_4294 ENOG4107RDP Dehydrogenase BF26_4298 ENOG4105CPP Dehydrogenase, E1 component BF26_4299 ENOG4105C7S Dehydrogenase BF26_430 ENOG4105FQP Beta-lactamase BF26_4301 ENOG4105E09 nadh pyrophosphatase BF26_4302 ENOG4105G7B Protein of unknown function (DUF2992) BF26_4304 ENOG4108HW3 (ABC) transporter BF26_4305 ENOG4105E5Q amino acid AbC transporter BF26_4306 ENOG4105CDA abc transporter atp-binding protein BF26_4307 ENOG4108QEG Membrane BF26_4308 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BF26_4310 ENOG4105D9U N-acetyltransferase BF26_4311 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF26_4313 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF26_4317 ENOG4105EJQ L-serine dehydratase BF26_4318 ENOG4105II7 pyrroline-5-carboxylate reductase BF26_4320 ENOG41069FQ Metallo-beta-lactamase superfamily BF26_4321 ENOG4108IXY short-chain dehydrogenase reductase BF26_4324 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BF26_433 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF26_433 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF26_4332 ENOG4105CGH 5'-nucleotidase BF26_4333 ENOG4105DFD Na H antiporter BF26_4335 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF26_4337 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BF26_4338 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF26_4339 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF26_4340 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BF26_4344 ENOG4108R6K riboflavin synthase, subunit alpha BF26_4345 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BF26_4349 ENOG4108YM7 Gcn5-related n-acetyltransferase BF26_4350 ENOG4105ETE Transcriptional regulator (LacI family BF26_4352 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF26_4356 ENOG4105RHY Pfam:UPF0157 BF26_4358 ENOG4105CPC Aldo Keto reductase BF26_4362 ENOG4105MZ9 stage II sporulation protein m BF26_4363 ENOG4105I3K Ferric uptake regulator, Fur family BF26_4365 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF26_4370 ENOG4105D7N magnesium and cobalt transport protein CorA BF26_4376 ENOG4105DVE abc transporter atp-binding protein BF26_4377 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF26_4378 ENOG4105DZ1 carboxypeptidase BF26_4379 ENOG41082AN stage II sporulation protein BF26_4381 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF26_4382 ENOG4105C8J )-transporter BF26_4386 ENOG41090VF Stage v sporulation protein ac BF26_4387 ENOG4105CZ3 stage V sporulation protein ad BF26_4389 ENOG4105G6R Stage v sporulation protein ae BF26_4391 ENOG4105J7I hydrolase BF26_4392 ENOG4105PTM secreted protein BF26_4393 ENOG4107ZE5 PPIases accelerate the folding of proteins BF26_4400 ENOG4105CE4 GlcNAc 6-P deacetylase BF26_4402 ENOG4105FDP GntR family transcriptional regulator BF26_4404 ENOG4105CID antiterminator BF26_4407 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BF26_4411 ENOG4106TD9 Diguanylate cyclase BF26_4412 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF26_4413 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF26_4416 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BF26_442 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF26_4421 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BF26_4423 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BF26_4425 ENOG4105DTD Dehydrogenase BF26_4426 ENOG4105K7K Transcriptional regulator BF26_4433 ENOG4105CHU acetyl-coa acetyltransferase BF26_444 ENOG4105T9C HD domain BF26_4442 ENOG4105CG3 alpha amylase, catalytic region BF26_4444 ENOG4107FKK extracellular solute-binding protein family 1 BF26_4446 ENOG4105EG2 ABC transporter, permease BF26_4447 ENOG4105FKQ transcriptional regulator BF26_4448 ENOG4105CHM Aminotransferase BF26_4450 ENOG4108HGU Histidine kinase BF26_4461 ENOG4105UIN BF26_4463 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF26_4466 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BF26_4467 ENOG4105EPM Diguanylate phosphodiesterase BF26_447 ENOG4105DZ1 carboxypeptidase BF26_4470 ENOG4107IN1 Protein of unknown function (DUF1797) BF26_4472 ENOG4108XRC Protein of unknown function (DUF458) BF26_4479 ENOG4107ZYR domain protein BF26_4480 ENOG4105CN5 Metallo-Beta-Lactamase BF26_4482 ENOG4108X4Q Hydrolase BF26_4483 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF26_4486 ENOG4105CPP Dehydrogenase, E1 component BF26_4487 ENOG4105C7S Dehydrogenase BF26_4496 ENOG4105CXN decarboxylase BF26_45 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BF26_450 ENOG4105DBI uridine monophosphokinase BF26_4500 ENOG4105ECY inositol monophosphatase BF26_4502 ENOG4105CI3 gtp-binding protein typa BF26_4503 ENOG4105QA2 BF26_4507 ENOG4108IAB Phoh family BF26_451 ENOG4105WCN acetyltransferase BF26_4510 ENOG4105CNI cell division protein FtsW BF26_4511 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BF26_4521 ENOG4106UY4 Inherit from COG: Scp-like extracellular BF26_4524 ENOG4107TB6 phosphoglycerate mutase BF26_4529 ENOG4106H78 methyltransferase BF26_453 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF26_4530 ENOG4105H20 Sporulation integral membrane protein YlbJ BF26_4532 ENOG4105D78 K07001 NTE family protein BF26_4533 ENOG41063PX domain protein BF26_4535 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BF26_454 ENOG4107QX3 carboxylase BF26_4543 ENOG4108IMY Transcriptional regulator BF26_455 ENOG4105E39 Enoyl-CoA hydratase BF26_4554 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF26_4557 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BF26_456 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BF26_457 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BF26_4575 ENOG4105CAR Terminase, large subunit BF26_4577 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF26_458 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF26_459 ENOG4105C1G acyl-Coa dehydrogenase BF26_4594 ENOG4105XSJ toxin secretion phage lysis holin BF26_46 ENOG4105DKT Transcriptional regulator BF26_4605 ENOG4105KNH Nucleic acid-binding protein BF26_4612 ENOG41068DC Essential cell division protein (By similarity) BF26_4613 ENOG4105CJN penicillin-binding protein BF26_4614 ENOG4105CJN penicillin-binding protein BF26_4615 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF26_4618 ENOG4105CNI cell division protein FtsW BF26_4619 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF26_462 ENOG4107Z3H Transcriptional regulator, TetR family BF26_4620 ENOG4105D4A Cell wall formation (By similarity) BF26_4621 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BF26_4622 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BF26_4623 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BF26_4625 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF26_4627 ENOG4105WR5 sporulation protein, YlmC YmxH family BF26_4628 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BF26_4629 ENOG4105DFA alanine racemase domain protein BF26_4631 ENOG41067XK integral membrane protein BF26_4632 ENOG4105DBK s4 domain protein BF26_4634 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF26_4637 ENOG4105C34 Pseudouridine synthase BF26_464 ENOG4105CJ1 ABC, transporter BF26_4642 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BF26_4653 ENOG4105DC7 peptidase M24 BF26_4654 ENOG4105F23 Fibronectin-binding protein BF26_4656 ENOG4105DSJ YicC domain protein BF26_4660 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BF26_4661 ENOG4105C25 Primosomal protein n' BF26_4662 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF26_4664 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF26_4666 ENOG4108ZF3 Phosphatase BF26_4667 ENOG4105D9P serine threonine protein kinase BF26_4668 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BF26_4669 ENOG4105DJV ribulose-phosphate 3-epimerase BF26_467 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BF26_4670 ENOG4105FJ0 thiamine BF26_4672 ENOG4108ZAA Alkaline-shock protein BF26_4673 ENOG4105DP4 dak2 domain fusion protein ylov BF26_4674 ENOG4105CB5 ATP-dependent DNA helicase recG BF26_4677 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BF26_4678 ENOG4105CHR reductase BF26_468 ENOG4105CEP NADH dehydrogenase BF26_4681 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BF26_4682 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BF26_4686 ENOG4105VB6 UPF0109 protein BF26_469 ENOG4106ANW SMI1_KNR4 BF26_4691 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BF26_4694 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BF26_4696 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF26_4698 ENOG4108HE4 integrase family BF26_4706 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BF26_4707 ENOG4105KNE Phosphatidate cytidylyltransferase BF26_4708 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF26_4709 ENOG4105DZP Membrane-associated zinc metalloprotease BF26_471 ENOG4105BZU Histidine kinase BF26_4711 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF26_4713 ENOG4105CHV Transcription elongation factor NusA BF26_4714 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BF26_4715 ENOG4105VHM ribosomal protein BF26_4717 ENOG4105W7A Protein of unknown function (DUF503) BF26_4719 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BF26_4720 ENOG4105DTN riboflavin biosynthesis protein ribF BF26_4724 ENOG4105C1V Peptidase, M16 BF26_4726 ENOG4105E35 Dipicolinate synthase subunit A BF26_4727 ENOG4108S0H Dipicolinic acid synthetase, b subunit BF26_4728 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF26_473 ENOG4105C5H ABC transporter BF26_4730 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF26_4732 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BF26_4734 ENOG4107QZI cell division protein FtsK BF26_4735 ENOG4105FDP GntR family transcriptional regulator BF26_4736 ENOG4105DIH basic membrane BF26_4737 ENOG4108JQ9 ABC transporter BF26_4738 ENOG4105UIB (ABC) transporter BF26_4739 ENOG4105UIB (ABC) transporter BF26_474 ENOG41067SE Tetr family transcriptional regulator BF26_4743 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BF26_4744 ENOG4105XZV Protein of unknown function (DUF3243) BF26_4747 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BF26_4752 ENOG4105D48 metallophosphoesterase BF26_4753 ENOG4105MCT stage V sporulation protein S BF26_4754 ENOG4108IGT Dipeptidase BF26_4755 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BF26_4756 ENOG4105DQU oxidoreductase, subunit beta BF26_4757 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF26_4762 ENOG4105DA5 (ABC) transporter BF26_4767 ENOG4107QHE Choloylglycine hydrolase BF26_4769 ENOG410890F Dynamin family BF26_4770 ENOG4105E0M Sulfatase BF26_4773 ENOG4105F0V Cell wall hydrolase BF26_4777 ENOG4107YEI lmbE family BF26_4778 ENOG4107TTQ Alpha beta hydrolase fold BF26_4781 ENOG41067MG lrgb family BF26_4784 ENOG4105BZU Histidine kinase BF26_4785 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BF26_479 ENOG4108VXD carboxy-peptidase BF26_4791 ENOG4105D03 DNA-3-methyladenine glycosylase II BF26_4792 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF26_4794 ENOG4105CGK Exodeoxyribonuclease III BF26_4798 ENOG4105E0A ABC, transporter BF26_4799 ENOG4105NIV Esterase BF26_48 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BF26_4801 ENOG4105VPX protein, conserved in bacteria BF26_4802 ENOG410681U heavy metal transport detoxification protein BF26_4803 ENOG4105C59 p-type ATPase BF26_4804 ENOG4105K70 DNA-binding protein BF26_4805 ENOG4105TMB Formate nitrite transporter BF26_4809 ENOG4105C85 amino acid BF26_4812 ENOG4108SJC Membrane BF26_4813 ENOG4107QW4 alcohol dehydrogenase BF26_4814 ENOG4107QW4 alcohol dehydrogenase BF26_4815 ENOG4105E98 transcriptional regulator DeoR family BF26_4816 ENOG4105DE4 1-phosphofructokinase BF26_4817 ENOG4105DM4 PTS System BF26_4818 ENOG41069ER domain protein BF26_482 ENOG4105VZ8 Transcriptional regulator BF26_4825 ENOG4106F1P AAA ATPase, central domain protein BF26_4826 ENOG4105EN6 Membrane BF26_4827 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF26_4828 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF26_4829 ENOG4105CXI aluminum resistance protein BF26_4830 ENOG4105KV4 Transcriptional regulator BF26_4831 ENOG4105C5F glutamine synthetase BF26_485 ENOG4105CGH 5'-nucleotidase BF26_4852 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BF26_486 ENOG4105CGH 5'-nucleotidase BF26_4892 ENOG4105XSJ toxin secretion phage lysis holin BF26_4893 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BF26_490 ENOG4105DH8 myo-inositol catabolism BF26_4901 ENOG4105K7K Transcriptional regulator BF26_4905 ENOG4108SVB resolvase BF26_4907 ENOG4105CGH 5'-nucleotidase BF26_491 ENOG4105D2N Aldolase BF26_4910 ENOG4105D5T phosphonate abc transporter BF26_4913 ENOG4105D7V transposase BF26_4917 ENOG4105BZ1 (ABC) transporter BF26_4918 ENOG4105BZ1 (ABC) transporter BF26_4921 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF26_4926 ENOG41067MG lrgb family BF26_4927 ENOG4105VAW lrga family BF26_4928 ENOG4107RSM transcriptional regulator BF26_4930 ENOG4107QIV Cytochrome c biogenesis protein BF26_4941 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BF26_4946 ENOG4108903 Formimidoylglutamase BF26_4947 ENOG4108VJ1 Transcriptional regulator (CarD family BF26_4948 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF26_4949 ENOG4105CBC glutamate synthase BF26_4950 ENOG4105CK7 Sodium proline symporter BF26_4951 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BF26_4952 ENOG4105FBA Phospholipase Carboxylesterase BF26_4956 ENOG4107AYK membrAne BF26_496 ENOG4105CK5 oxidoreductase BF26_4965 ENOG4105CEY Amp-dependent synthetase and ligase BF26_4966 ENOG4107ZYJ bioY protein BF26_4967 ENOG4107F3J Amp-dependent synthetase and ligase BF26_497 ENOG4105IE8 Alpha-ketoglutarate permease BF26_4971 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF26_4973 ENOG4105E5W Transporter BF26_4978 ENOG4108I0Z Aconitate hydratase BF26_4979 ENOG4108JJA ABC, transporter BF26_498 ENOG4105ETE Transcriptional regulator (LacI family BF26_4981 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF26_4982 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF26_4988 ENOG4105W8X HesB YadR YfhF-family protein BF26_4989 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF26_499 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF26_4990 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BF26_4992 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF26_4993 ENOG4105C0H protease BF26_4994 ENOG4105K4P CoA-binding domain protein BF26_4995 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF26_4997 ENOG4105D9R oxidoreductase BF26_4999 ENOG4105CIG ABC transporter BF26_5 ENOG4105CKK Glycosyl transferase, family 2 BF26_50 ENOG4105D4B ABC, transporter BF26_5003 ENOG4105EMN RNA polymerase sigma factor BF26_5005 ENOG4108KGH TRANSCRIPTIONal BF26_5006 ENOG4107QJT sodium dicarboxylate symporter BF26_501 ENOG4107RF6 penicillin-binding protein BF26_5018 ENOG4105E1K spore germination protein BF26_502 ENOG4107RF6 penicillin-binding protein BF26_5020 ENOG4108JB9 formate dehydrogenase BF26_5022 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BF26_5023 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF26_5025 ENOG4105TMB Formate nitrite transporter BF26_5026 ENOG4105D06 uba thif-type nad fad binding protein BF26_5027 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF26_5028 ENOG4108ZAF Molybdopterin BF26_503 ENOG4107RF6 penicillin-binding protein BF26_5030 ENOG4105D1F ATP-binding protein BF26_5033 ENOG410696E Membrane BF26_5034 ENOG4105FR1 rard protein BF26_5036 ENOG4105EWU Squalene--hopene cyclase BF26_5038 ENOG4105CHR reductase BF26_5039 ENOG4105C26 Dehydrogenase BF26_5041 ENOG4108IA2 Sodium pantothenate symporter BF26_5044 ENOG4106IQC argininosuccinate lyase BF26_5046 ENOG410904N short-chain dehydrogenase reductase BF26_5050 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BF26_5054 ENOG4105VEQ Cold shock protein BF26_5058 ENOG4108R1P BF26_5060 ENOG41073R8 VanW family BF26_5061 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF26_5063 ENOG4105KT7 mgtC SapB transporter BF26_5065 ENOG4105E39 Enoyl-CoA hydratase BF26_5066 ENOG4105K64 Glycosyl transferase, family 2 BF26_5068 ENOG4108UT6 Transferase hexapeptide repeat containing protein BF26_5072 ENOG4105CQB FAD linked oxidase domain protein BF26_5073 ENOG4105C09 Bile acid BF26_5075 ENOG4105RHY Pfam:UPF0157 BF26_5081 ENOG4105CIS alcohol dehydrogenase BF26_5082 ENOG41082BM Transcriptional regulator, arsr family BF26_5086 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF26_509 ENOG4105CIN aminoacyl-histidine dipeptidase BF26_5092 ENOG4108A04 Beta-lactamase BF26_5095 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BF26_5096 ENOG4105E5K Alpha-amylase BF26_5098 ENOG4105C98 muts2 protein BF26_5102 ENOG4107V2S Transcriptional regulator BF26_5104 ENOG4107CUJ Protein of unknown function (DUF2690) BF26_5108 ENOG4107ZY0 Phenazine biosynthesis-like protein BF26_5109 ENOG4105NX3 Membrane BF26_5110 ENOG4105DQ5 transport system permease protein BF26_5111 ENOG4105EHG Permease protein BF26_5113 ENOG4108MES Periplasmic binding protein BF26_5117 ENOG4107R3E Citrate transporter BF26_5119 ENOG4108TN2 lmbE family BF26_5126 ENOG4105CIS alcohol dehydrogenase BF26_5133 ENOG4105H3G oxidoreductase BF26_5135 ENOG4105ED2 Beta-lactamase BF26_5140 ENOG4107YXZ hydrolase, family 25 BF26_5144 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BF26_5149 ENOG4105KAF membrAne BF26_5159 ENOG4108ZJ4 polysaccharide deacetylase BF26_5163 ENOG4105KVH Transcriptional regulator BF26_5164 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BF26_5168 ENOG4105CHR reductase BF26_517 ENOG41090HR transcriptional regulator BF26_5170 ENOG4105JAB phenazine biosynthesis protein, phzf family BF26_5177 ENOG4105KVH Transcriptional regulator BF26_5178 ENOG4105KVH Transcriptional regulator BF26_5179 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BF26_518 ENOG4107RA9 decarboxylase BF26_5181 ENOG4105D9R oxidoreductase BF26_5182 ENOG4108TZY GntR Family Transcriptional Regulator BF26_5183 ENOG4105KVH Transcriptional regulator BF26_5189 ENOG4105C44 Serine transporter BF26_519 ENOG4108I0C methyltransferase BF26_5190 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BF26_5193 ENOG4105F27 Major Facilitator BF26_5194 ENOG4105CV8 reductase BF26_5198 ENOG4105D4Y metalloprotease BF26_5199 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BF26_5202 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BF26_5203 ENOG4105CIS alcohol dehydrogenase BF26_5204 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF26_5205 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF26_5208 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF26_5209 ENOG4105C6Z Gluconate BF26_521 ENOG41088CC tellurite resistance protein tehB BF26_5210 ENOG4105CMG Carbohydrate kinase BF26_5211 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BF26_5212 ENOG4105XDF Protein of unknown function (DUF1272) BF26_5213 ENOG4105DDN Pentapeptide repeat-containing protein BF26_5216 ENOG4105C37 (CBS) domain BF26_5222 ENOG4105EV4 Multidrug resistance protein mdtH BF26_5224 ENOG4105DMQ Methyltransferase BF26_5229 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF26_5230 ENOG4105C31 Tryptophanyl-tRNA synthetase BF26_5232 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF26_5234 ENOG4108UW5 maltose o-acetyltransferase BF26_5235 ENOG4106UW1 Major Facilitator superfamily BF26_5236 ENOG4105DKQ ROK family BF26_5237 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BF26_5249 ENOG4105CJ1 ABC, transporter BF26_525 ENOG4108RZE Tetr family transcriptional regulator BF26_5251 ENOG4108PSK reductase BF26_5255 ENOG4108RCM Nitroreductase BF26_5256 ENOG4105KVH Transcriptional regulator BF26_5259 ENOG4105CUT histidyl-tRNA synthetase BF26_5260 ENOG4108Z66 YbaK ebsC protein BF26_5262 ENOG41067QW Transcriptional regulator BF26_5265 ENOG4108K8S endonuclease I BF26_527 ENOG4105C1J atp-dependent rna helicase BF26_5270 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF26_5278 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF26_5280 ENOG4105CRW Short chain fatty acid transporter BF26_5282 ENOG4105KBX Transcriptional regulator, TetR family BF26_5283 ENOG4105KPY Small multidrug resistance protein BF26_5284 ENOG4105RXJ BF26_5286 ENOG41069JR BF26_5287 ENOG4105DA5 (ABC) transporter BF26_5291 ENOG4105CZM Major Facilitator BF26_5292 ENOG4107MII Sugar-specific transcriptional regulator TrmB BF26_5294 ENOG4108ISG Major Facilitator BF26_530 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF26_5302 ENOG4105HIR S-layer domain protein BF26_5305 ENOG410874W AraC family transcriptional regulator BF26_5306 ENOG41082W1 Cupin 2, conserved barrel domain protein BF26_5309 ENOG4108AEY RNA polymerase sigma factor BF26_5313 ENOG4108JQ1 Dehydrogenase BF26_5316 ENOG4105DVH amino acid BF26_5318 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BF26_5321 ENOG4108JPW Aminotransferase BF26_5323 ENOG4105EJQ L-serine dehydratase BF26_5324 ENOG4105C44 Serine transporter BF26_5327 ENOG4108JGH Tetr family transcriptional regulator BF26_5328 ENOG4105EQ0 Major Facilitator superfamily BF26_5329 ENOG4105MZU cell filamentation protein BF26_533 ENOG4107STF Involved in phosphonate degradation (By similarity) BF26_5332 ENOG4107QJQ Mate efflux family protein BF26_5339 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF26_5347 ENOG4105TRI Hydrolase BF26_535 ENOG4105RD7 BadF BadG BcrA BcrD BF26_5353 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF26_5355 ENOG4106P55 Transcriptional regulator BF26_5357 ENOG4107QR9 Iron-sulfur cluster binding protein BF26_5358 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BF26_5359 ENOG4105DJB Major Facilitator Superfamily BF26_5360 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF26_5362 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BF26_5363 ENOG4108U05 Transcriptional regulator BF26_5366 ENOG4105BZU Histidine kinase BF26_5369 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BF26_5370 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF26_5373 ENOG4105JQZ Methyltransferase BF26_5374 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF26_5376 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BF26_5377 ENOG4108NNI Beta-lactamase domain-containing protein BF26_5380 ENOG4105VZ8 Transcriptional regulator BF26_5386 ENOG4105K6H D-cysteine desulfhydrase BF26_5391 ENOG41062D9 Histidine kinase BF26_5392 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF26_5395 ENOG4105IIP Membrane BF26_5397 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF26_5398 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BF26_540 ENOG4105F32 YngK protein BF26_5412 ENOG4108YXU transcriptional regulator AsnC family BF26_5413 ENOG4105CHR reductase BF26_5415 ENOG4105F7F Chaperone BF26_5419 ENOG41085FC arsR family transcriptional regulator BF26_5420 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BF26_5421 ENOG4105D6J arsenicaL-resistance protein BF26_5427 ENOG4105DIK (ABC) transporter BF26_5428 ENOG4105CC5 ABC transporter BF26_5429 ENOG4105DSE periplasmic solute binding protein BF26_5430 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BF26_5431 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF26_5433 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BF26_5434 ENOG4108TWJ NADH dehydrogenase subunit 5 BF26_5437 ENOG4105CVP deoxyribo-dipyrimidine photolyase BF26_5438 ENOG4108606 TspO/MBR family BF26_5446 ENOG41090MY MarR family Transcriptional regulator BF26_545 ENOG4108KPJ rna polymerase sigma factor BF26_5452 ENOG4105CHJ isochorismatase hydrolase BF26_5454 ENOG4105CH6 catalase BF26_5455 ENOG4105CGH 5'-nucleotidase BF26_5463 ENOG4105CSV Glutaminase BF26_5468 ENOG4108Q8B Spore germination protein BF26_5469 ENOG4108NHD germination protein BF26_5470 ENOG4108NHD germination protein BF26_5473 ENOG4105C6K Malic enzyme BF26_5475 ENOG4105II7 pyrroline-5-carboxylate reductase BF26_5477 ENOG4105CUB amino acid BF26_5478 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF26_5480 ENOG4108IMY Transcriptional regulator BF26_5481 ENOG4105HDK L-asparaginase BF26_5482 ENOG4108IJ0 Aspartate ammonia-lyase BF26_5485 ENOG4105E2A Dehydrogenase BF26_550 ENOG4108JCI Transcriptional regulator BF26_5501 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF26_5507 ENOG4105DWD nucleoside recognition domain protein BF26_5511 ENOG4105FDT acyl-CoA dehydrogenase BF26_5513 ENOG4108ZHR arsR family transcriptional regulator BF26_5514 ENOG4108ZRV stage ii sporulation protein p BF26_5515 ENOG4106N3A copper homeostasis protein cutc BF26_5517 ENOG4107258 Transcriptional regulator BF26_5518 ENOG4105P4J Allophanate hydrolase, subunit 1 BF26_5525 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BF26_5527 ENOG4107RF6 penicillin-binding protein BF26_5535 ENOG4105F1N DNA alkylation repair BF26_5537 ENOG4108IQI permease BF26_5538 ENOG4105KNA -acetyltransferase BF26_5539 ENOG410635A Membrane BF26_554 ENOG4105BZ1 (ABC) transporter BF26_555 ENOG4105BZ1 (ABC) transporter BF26_5555 ENOG4108XET gCN5-related N-acetyltransferase BF26_5561 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF26_5563 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF26_5570 ENOG4105FS7 Transcriptional regulator BF26_5571 ENOG4108TVJ Nitroreductase BF26_5573 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF26_5582 ENOG4105C8Y Acetylornithine aminotransferase BF26_5584 ENOG4105CKK Glycosyl transferase, family 2 BF26_5585 ENOG4108J59 Extracellular solute-binding protein, family 5 BF26_5589 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF26_559 ENOG4105VEQ Cold shock protein BF26_5599 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF26_56 ENOG4105EMN RNA polymerase sigma factor BF26_5600 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF26_561 ENOG41068WN BF26_5614 ENOG4105K4H Nlp p60 protein BF26_563 ENOG4105C1Q protoporphyrinogen oxidase BF26_5648 ENOG4107QJE Chromosome Partitioning Protein BF26_5653 ENOG4105DQ6 Transposase BF26_5660 ENOG4105EWC Purine nucleoside phosphorylase BF26_5678 ENOG4105C3F Signal peptidase i BF26_5686 ENOG4105N14 lysine exporter protein LysE YggA BF26_569 ENOG4105WCN acetyltransferase BF26_574 ENOG4105EYF MMPL domain protein BF26_576 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF26_579 ENOG41081I9 integral membrane protein BF26_58 ENOG41069ER domain protein BF26_585 ENOG4108D32 Methyltransferase BF26_591 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF26_595 ENOG4105C22 threonyL-tRNA synthetase BF26_596 ENOG4105FE9 pseudouridine synthase BF26_600 ENOG4105BZG amino acid carrier protein BF26_604 ENOG4105K70 DNA-binding protein BF26_607 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF26_608 ENOG4105WQT MbtH domain protein BF26_609 ENOG4105CEY Amp-dependent synthetase and ligase BF26_610 ENOG4105WQI isochorismatase BF26_611 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BF26_612 ENOG4105E4F Isochorismate synthase BF26_613 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BF26_614 ENOG4105FCD Major Facilitator BF26_618 ENOG4105EYH Exonuclease BF26_619 ENOG4107RFY SbcCD D subunit BF26_622 ENOG4105E39 Enoyl-CoA hydratase BF26_623 ENOG4105N14 lysine exporter protein LysE YggA BF26_625 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF26_626 ENOG4105C1G acyl-Coa dehydrogenase BF26_627 ENOG4105CR4 methylisocitrate lyase BF26_628 ENOG4105DXD 2-methylcitrate dehydratase BF26_630 ENOG4105W8X HesB YadR YfhF-family protein BF26_631 ENOG4105CZM Major Facilitator BF26_632 ENOG4105BZ4 penicillin-binding protein BF26_640 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF26_659 ENOG4108IBT Inherit from COG: transposase BF26_66 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF26_661 ENOG4105SZ6 Thioredoxin BF26_662 ENOG410841Q phosphoesterase PA-phosphatase related protein BF26_664 ENOG4108N23 SpoOM-related protein BF26_67 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BF26_672 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BF26_673 ENOG4108JUB Transcriptional regulator BF26_674 ENOG4108TSC N-acetyltransferase BF26_675 ENOG4107S4Y M20 DapE family protein YgeY BF26_678 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF26_68 ENOG4105CIH Imidazole acetol-phosphate transaminase BF26_692 ENOG4105E90 ABC transporter BF26_693 ENOG4108IJ8 ABC transporter BF26_699 ENOG4105CMG Carbohydrate kinase BF26_700 ENOG4105CMG Carbohydrate kinase BF26_708 ENOG4106KNT transcriptional regulator BF26_710 ENOG4105WH1 Two component transcriptional regulator luxr family BF26_711 ENOG4105BZU Histidine kinase BF26_712 ENOG4105D8X mechanosensitive ion channel BF26_719 ENOG4105F0I Aminotransferase BF26_72 ENOG41082JN Transcriptional regulator BF26_720 ENOG4108MES Periplasmic binding protein BF26_724 ENOG4105CAQ asparagine synthetase BF26_725 ENOG4107Y70 Heat shock protein BF26_726 ENOG4108KF3 Electron transport protein SCO1 SenC BF26_727 ENOG4105E8R UPF0173 metal-dependent hydrolase BF26_728 ENOG4108RCR degv family BF26_73 ENOG4105EYF MMPL domain protein BF26_730 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BF26_732 ENOG4108UT2 hemolysin iii BF26_733 ENOG4105E9Q Acyl-transferase BF26_734 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF26_735 ENOG4107RVG penicillin-binding protein BF26_738 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BF26_74 ENOG4105EYF MMPL domain protein BF26_742 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BF26_747 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BF26_749 ENOG4105KD7 acetyltransferase BF26_76 ENOG4105C5H ABC transporter BF26_769 ENOG4105EC2 ftsk spoIIIe BF26_77 ENOG4105E0M Sulfatase BF26_773 ENOG4105C5S asparaginyl-tRNA synthetase BF26_774 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF26_777 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF26_78 ENOG4108ZCF integral membrane protein BF26_783 ENOG4105C75 arginyL-tRNA synthetase BF26_784 ENOG4107YX5 Pfam:DUF548 BF26_788 ENOG41061H0 Monooxygenase BF26_791 ENOG4108UUM single-stranded DNA-binding protein BF26_794 ENOG4105C5H ABC transporter BF26_798 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF26_80 ENOG4107VMI polysaccharide deacetylase BF26_801 ENOG4105MCT stage V sporulation protein S BF26_808 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF26_809 ENOG4108IFG nitrite reductase, (NAD(P)H) BF26_810 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BF26_811 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF26_812 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF26_813 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF26_818 ENOG4108ZAF Molybdopterin BF26_819 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF26_82 ENOG4107VC0 DNA alkylation repair enzyme BF26_820 ENOG4105D06 uba thif-type nad fad binding protein BF26_821 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF26_822 ENOG4107V6Q Cyclic nucleotide-binding domain BF26_827 ENOG4105R3A Nitrate reductase BF26_828 ENOG4108IUE nitrate reductase beta subunit BF26_832 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF26_835 ENOG4108V06 Glutathione peroxidase BF26_840 ENOG4105EMN RNA polymerase sigma factor BF26_841 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BF26_843 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BF26_844 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BF26_848 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF26_853 ENOG4105KBJ sporulation protein ytfj BF26_862 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF26_868 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF26_869 ENOG4108JYZ YitT family BF26_870 ENOG41087PP glycosyltransferase MGT family BF26_873 ENOG4107RBS Methyltransferase BF26_874 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF26_876 ENOG4108X4Q Hydrolase BF26_881 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF26_883 ENOG4108VXD carboxy-peptidase BF26_885 ENOG4108ZRV stage ii sporulation protein p BF26_889 ENOG4108Z7R Chaperone CsaA BF26_893 ENOG4105C37 (CBS) domain BF26_894 ENOG4105SXS Protein of unknown function (DUF456) BF26_898 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF26_899 ENOG4108S4H thioesterase Superfamily protein BF26_901 ENOG4108PJD permease BF26_904 ENOG4107T5V SNARE associated Golgi BF26_908 ENOG4105CVJ phosphoglycerate mutase BF26_913 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF26_915 ENOG4105K4T epimerase BF26_917 ENOG4105DSE periplasmic solute binding protein BF26_92 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BF26_929 ENOG4105CKI cobalamin synthesis protein BF26_930 ENOG4107QM2 Aldo Keto reductase BF26_934 ENOG4105DEN Luciferase family BF26_937 ENOG4108WPJ Ferritin-like domain BF26_938 ENOG4108K88 Membrane BF26_941 ENOG4105C8Q Methyl-accepting chemotaxis BF26_946 ENOG4107XZQ multidrug resistance protein BF26_947 ENOG4107SET aldo keto reductase BF26_948 ENOG4105YVS arsR family transcriptional regulator BF26_950 ENOG4105KRN Transcriptional regulator, abrb family BF26_96 ENOG4105E09 nadh pyrophosphatase BF26_961 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF26_964 ENOG4105YWU small acid-soluble spore protein BF26_965 ENOG4108WBH protein TIM barrel BF26_968 ENOG4105CEY Amp-dependent synthetase and ligase BF26_969 ENOG4105DUU IucA IucC family protein BF26_971 ENOG4105VRR gCN5-related N-acetyltransferase BF26_972 ENOG4105KT7 mgtC SapB transporter BF26_974 ENOG4107VMI polysaccharide deacetylase BF26_975 ENOG4105BZU Histidine kinase BF26_976 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF26_978 ENOG4108KGH TRANSCRIPTIONal BF26_983 ENOG4105D6E homoserine dehydrogenase BF26_987 ENOG4108ZJ4 polysaccharide deacetylase BF26_988 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BF26_991 ENOG4105BZU Histidine kinase BF26_992 ENOG4105EFI regulatoR BF26_993 ENOG4105BZ1 (ABC) transporter BF26_994 ENOG4105BZ1 (ABC) transporter