locus-tag	class	description
KM398_00010	COG0592	DNA-directed DNA polymerase activity
KM398_00015	COG2501	S4 domain
KM398_00025	COG0187	DNA topoisomerase II activity
KM398_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM398_00065	COG0516	GMP reductase activity
KM398_00065	COG0517	IMP dehydrogenase activity
KM398_00070	COG1686	Belongs to the peptidase S11 family
KM398_00100	COG1428	Deoxynucleoside kinase
KM398_00105	COG1428	Deoxynucleoside kinase
KM398_00110	COG1335	isochorismatase
KM398_00115	COG0590	tRNA wobble adenosine to inosine editing
KM398_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KM398_00180	COG1982	Orn Lys Arg decarboxylase major
KM398_00190	COG0470	DNA polymerase III
KM398_00195	COG1774	PSP1 C-terminal conserved region
KM398_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KM398_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KM398_00220	COG2002	toxin-antitoxin pair type II binding
KM398_00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM398_00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM398_00230	COG0084	hydrolase, TatD family'
KM398_00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM398_00250	COG4466	Protein conserved in bacteria
KM398_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KM398_00270	COG0251	oxidation-reduction process
KM398_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KM398_00305	COG2002	toxin-antitoxin pair type II binding
KM398_00310	COG2244	polysaccharide biosynthetic process
KM398_00315	COG3956	TIGRFAM MazG family protein
KM398_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KM398_00340	COG1098	S1 RNA binding domain
KM398_00355	COG2208	phosphoserine phosphatase activity
KM398_00360	COG0037	tRNA processing
KM398_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KM398_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM398_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM398_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KM398_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
KM398_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM398_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KM398_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KM398_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KM398_00420	COG1396	sequence-specific DNA binding
KM398_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM398_00455	COG3880	PFAM UvrB UvrC protein
KM398_00465	COG0542	response to heat
KM398_00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KM398_00480	COG4956	integral membrane protein (PIN domain superfamily)
KM398_00500	COG1045	serine acetyltransferase
KM398_00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM398_00520	COG3688	RNA-binding protein containing a PIN domain
KM398_00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM398_00540	COG0250	Participates in transcription elongation, termination and antitermination
KM398_00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KM398_00565	COG2813	Specifically methylates the guanine in position
KM398_00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KM398_00580	COG1358	cellular component organization or biogenesis
KM398_00650	COG0255	Belongs to the universal ribosomal protein uL29 family
KM398_00710	COG0201	protein transport
KM398_00720	COG0024	Methionine aminopeptidase
KM398_00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KM398_00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM398_00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM398_00795	COG0489	protein tyrosine kinase activity
KM398_00805	COG2194	sulfuric ester hydrolase activity
KM398_00810	COG0726	polysaccharide deacetylase
KM398_00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KM398_00895	COG4856	YbbR-like protein
KM398_00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KM398_00915	COG0596	Alpha beta hydrolase
KM398_00935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KM398_00940	COG0823	Involved in the tonB-independent uptake of proteins
KM398_00940	COG1506	peptidase
KM398_00940	COG4946	Tricorn protease homolog
KM398_00975	COG2011	ABC-type metal ion transport system permease component
KM398_00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM398_00985	COG1464	Belongs to the NlpA lipoprotein family
KM398_00990	COG0604	alcohol dehydrogenase
KM398_01000	COG0277	FAD linked oxidase domain protein
KM398_01005	COG2271	Major facilitator Superfamily
KM398_01015	COG2814	Major facilitator Superfamily
KM398_01030	COG0601	transmembrane transport
KM398_01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM398_01040	COG0444	Belongs to the ABC transporter superfamily
KM398_01045	COG4608	Belongs to the ABC transporter superfamily
KM398_01050	COG4166	transmembrane transport
KM398_01060	COG2207	Transcriptional regulator
KM398_01080	COG4166	transmembrane transport
KM398_01085	COG0656	L-ascorbic acid biosynthetic process
KM398_01090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM398_01105	COG4149	molybdate abc transporter
KM398_01115	COG1910	domain protein
KM398_01125	COG0583	DNA-binding transcription factor activity
KM398_01130	COG0697	spore germination
KM398_01145	COG0204	Acyl-transferase
KM398_01155	COG1609	Transcriptional regulator
KM398_01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM398_01175	COG0084	hydrolase, TatD family'
KM398_01180	COG5298	Protein conserved in bacteria
KM398_01205	COG0488	(ABC) transporter
KM398_01220	COG0747	negative chemotaxis
KM398_01225	COG0601	transmembrane transport
KM398_01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM398_01235	COG0444	Belongs to the ABC transporter superfamily
KM398_01240	COG4608	Belongs to the ABC transporter superfamily
KM398_01275	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KM398_01280	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM398_01290	COG2814	Major facilitator Superfamily
KM398_01300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KM398_01310	COG4294	response to UV
KM398_01315	COG0457	Tetratricopeptide repeat
KM398_01315	COG0705	Rhomboid family
KM398_01325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KM398_01330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM398_01335	COG0864	Transcriptional regulator
KM398_01340	COG2337	Toxic component of a toxin-antitoxin (TA) module
KM398_01345	COG2183	response to ionizing radiation
KM398_01440	COG0802	atpase or kinase
KM398_01445	COG1214	PFAM Peptidase M22, glycoprotease
KM398_01450	COG0456	acetyltransferase
KM398_01460	COG0488	(ABC) transporter
KM398_01475	COG1266	CAAX protease self-immunity
KM398_01495	COG2252	PERMEase
KM398_01505	COG5002	protein histidine kinase activity
KM398_01535	COG2226	methyltransferase
KM398_01575	COG1968	undecaprenyl-diphosphatase activity
KM398_01590	COG2205	protein histidine kinase activity
KM398_01595	COG0745	RESPONSE REGULATOR receiver
KM398_01615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KM398_01620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KM398_01625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KM398_01635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KM398_01650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KM398_01660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KM398_01670	COG0151	Belongs to the GarS family
KM398_01695	COG0210	DNA helicase
KM398_01705	COG4851	CamS sex pheromone cAM373 precursor
KM398_01725	COG1335	isochorismatase
KM398_01730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM398_01735	COG2011	ABC-type metal ion transport system permease component
KM398_01740	COG1464	Belongs to the NlpA lipoprotein family
KM398_01760	COG1846	Transcriptional regulator
KM398_01785	COG1597	lipid kinase activity
KM398_01790	COG0546	phosphoglycolate phosphatase activity
KM398_01795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM398_01805	COG1012	belongs to the aldehyde dehydrogenase family
KM398_01810	COG2076	Multidrug Resistance protein
KM398_01815	COG2309	aminopeptidase activity
KM398_01830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM398_01835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM398_01840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM398_01850	COG4807	Protein conserved in bacteria
KM398_01875	COG1757	Na H antiporter
KM398_01880	COG1473	amidohydrolase
KM398_01895	COG0450	alkyl hydroperoxide reductase
KM398_01915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM398_01920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM398_01925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM398_01940	COG0166	Belongs to the GPI family
KM398_01975	COG5002	protein histidine kinase activity
KM398_01995	COG3541	Predicted nucleotidyltransferase
KM398_02000	COG2814	Major facilitator Superfamily
KM398_02005	COG0723	plastoquinol--plastocyanin reductase activity
KM398_02005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM398_02015	COG0765	amino acid transport
KM398_02020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM398_02030	COG0840	transmembrane signaling receptor activity
KM398_02035	COG0840	transmembrane signaling receptor activity
KM398_02040	COG0366	Alpha amylase catalytic
KM398_02045	COG2190	(PTS) system
KM398_02045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM398_02045	COG1263	PTS System
KM398_02075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KM398_02090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM398_02100	COG1116	anion transmembrane transporter activity
KM398_02105	COG0488	(ABC) transporter
KM398_02150	COG2270	Major facilitator Superfamily
KM398_02165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM398_02180	COG2310	stress, protein
KM398_02185	COG2310	stress, protein
KM398_02190	COG2310	stress, protein
KM398_02195	COG0861	Integral membrane protein TerC family
KM398_02205	COG3853	Toxic anion resistance protein (TelA)
KM398_02220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KM398_02230	COG1295	ribonuclease BN
KM398_02235	COG2217	Heavy metal translocating P-type atpase
KM398_02240	COG0697	spore germination
KM398_02260	COG0586	Pfam SNARE associated Golgi protein
KM398_02275	COG3871	stress protein (general stress protein 26)
KM398_02280	COG0387	Pfam Sodium calcium exchanger
KM398_02290	COG0535	radical SAM domain protein
KM398_02315	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM398_02320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM398_02325	COG0582	viral genome integration into host DNA
KM398_02335	COG1396	sequence-specific DNA binding
KM398_02350	COG1396	sequence-specific DNA binding
KM398_02380	COG1484	DNA-dependent DNA replication
KM398_02610	COG0101	tRNA pseudouridine synthase activity
KM398_02620	COG3829	transcription factor binding
KM398_02630	COG0833	amino acid
KM398_02635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM398_02665	COG1263	PTS System
KM398_02665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM398_02670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM398_02685	COG0463	Glycosyl transferase, family 2
KM398_02700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KM398_02700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM398_02720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KM398_02740	COG1228	amidohydrolase
KM398_02745	COG1090	epimerase
KM398_02775	COG1988	membrane-bound metal-dependent
KM398_02780	COG1194	a g-specific adenine glycosylase
KM398_02805	COG1132	(ABC) transporter
KM398_02810	COG4129	membrane
KM398_02815	COG0067	glutamate synthase
KM398_02815	COG0069	glutamate synthase activity
KM398_02815	COG0070	glutamate synthase
KM398_02825	COG4555	ABC transporter
KM398_02845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KM398_02850	COG0735	belongs to the Fur family
KM398_02965	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KM398_02970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KM398_02980	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KM398_02990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KM398_03000	COG2766	serine protein kinase
KM398_03020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM398_03030	COG1585	Membrane protein implicated in regulation of membrane protease activity
KM398_03035	COG2268	Band 7 protein
KM398_03045	COG3290	protein histidine kinase activity
KM398_03050	COG4565	transcriptional regulatory protein
KM398_03055	COG2851	Citrate transporter
KM398_03075	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM398_03080	COG3842	ATPase activity
KM398_03085	COG1175	transmembrane transport
KM398_03090	COG0395	ABC-type sugar transport system, permease component
KM398_03100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KM398_03105	COG0745	RESPONSE REGULATOR receiver
KM398_03110	COG5002	protein histidine kinase activity
KM398_03120	COG4990	cell redox homeostasis
KM398_03130	COG3290	protein histidine kinase activity
KM398_03135	COG4565	transcriptional regulatory protein
KM398_03140	COG3493	citrate carrier protein
KM398_03145	COG0281	malic enzyme
KM398_03160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM398_03170	COG5002	protein histidine kinase activity
KM398_03175	COG0745	RESPONSE REGULATOR receiver
KM398_03180	COG0456	acetyltransferase
KM398_03180	COG0454	-acetyltransferase
KM398_03185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM398_03190	COG3383	formate dehydrogenase (NAD+) activity
KM398_03195	COG2427	Protein of unknown function (DUF1641)
KM398_03210	COG0531	amino acid
KM398_03215	COG0640	Transcriptional regulator
KM398_03220	COG2217	Heavy metal translocating P-type atpase
KM398_03225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KM398_03240	COG3227	Zinc metalloprotease (Elastase)
KM398_03260	COG2720	vancomycin resistance protein
KM398_03265	COG1316	TRANSCRIPTIONal
KM398_03270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM398_03275	COG0346	lactoylglutathione lyase activity
KM398_03280	COG1253	flavin adenine dinucleotide binding
KM398_03285	COG1027	Aspartate ammonia-lyase
KM398_03290	COG1620	l-lactate permease
KM398_03305	COG3104	oligopeptide transport
KM398_03310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM398_03315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM398_03320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM398_03330	COG2226	methyltransferase
KM398_03335	COG0156	8-amino-7-oxononanoate synthase activity
KM398_03340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM398_03350	COG4548	von Willebrand factor, type A
KM398_03355	COG0714	Associated with various cellular activities
KM398_03360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM398_03380	COG0531	amino acid
KM398_03385	COG2188	Transcriptional regulator
KM398_03390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM398_03390	COG1263	PTS System
KM398_03395	COG0366	Alpha amylase catalytic
KM398_03410	COG0697	spore germination
KM398_03420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM398_03425	COG1115	amino acid carrier protein
KM398_03430	COG1126	abc transporter atp-binding protein
KM398_03435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM398_03440	COG0765	amino acid transport
KM398_03445	COG0765	amino acid transport
KM398_03450	COG0833	amino acid
KM398_03475	COG2378	regulation of single-species biofilm formation
KM398_03480	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KM398_03485	COG5002	protein histidine kinase activity
KM398_03500	COG0659	secondary active sulfate transmembrane transporter activity
KM398_03515	COG0747	negative chemotaxis
KM398_03525	COG0601	transmembrane transport
KM398_03530	COG4608	Belongs to the ABC transporter superfamily
KM398_03540	COG2271	Major facilitator Superfamily
KM398_03545	COG1846	Transcriptional regulator
KM398_03555	COG1609	Transcriptional regulator
KM398_03560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM398_03575	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM398_03580	COG1879	ABC-type sugar transport system periplasmic component
KM398_03605	COG1063	alcohol dehydrogenase
KM398_03620	COG3568	Endonuclease Exonuclease Phosphatase
KM398_03645	COG1968	undecaprenyl-diphosphatase activity
KM398_03650	COG0840	transmembrane signaling receptor activity
KM398_03655	COG3584	3D domain protein
KM398_03655	COG1388	LysM domain
KM398_03660	COG1476	TRANSCRIPTIONal
KM398_03675	COG3104	oligopeptide transport
KM398_03680	COG1114	Component of the transport system for branched-chain amino acids
KM398_03695	COG1113	amino acid transport
KM398_03700	COG2252	PERMEase
KM398_03725	COG0475	glutathione-regulated potassium exporter activity
KM398_03725	COG0569	domain protein
KM398_03740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KM398_03745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KM398_03750	COG0833	amino acid
KM398_03755	COG4990	cell redox homeostasis
KM398_03770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM398_03775	COG0697	spore germination
KM398_03780	COG0531	amino acid
KM398_03790	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM398_03795	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM398_03800	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM398_03800	COG1918	ferrous iron import across plasma membrane
KM398_03805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM398_03810	COG0573	inorganic phosphate transmembrane transporter activity
KM398_03815	COG0581	inorganic phosphate transmembrane transporter activity
KM398_03825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM398_03945	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KM398_03965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM398_03970	COG1116	anion transmembrane transporter activity
KM398_03975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM398_03980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM398_03985	COG0352	thiamine-phosphate diphosphorylase activity
KM398_03990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM398_03995	COG2104	thiamine diphosphate biosynthetic process
KM398_04005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM398_04010	COG0351	phosphomethylpyrimidine kinase
KM398_04050	COG2205	protein histidine kinase activity
KM398_04055	COG2814	Major facilitator Superfamily
KM398_04060	COG1846	Transcriptional regulator
KM398_04075	COG2252	PERMEase
KM398_04080	COG1028	Short-chain dehydrogenase reductase Sdr
KM398_04095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM398_04100	COG1621	beta-fructofuranosidase activity
KM398_04105	COG1263	PTS System
KM398_04105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM398_04110	COG1609	Transcriptional regulator
KM398_04120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM398_04125	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KM398_04160	COG0778	Nitroreductase
KM398_04165	COG2719	SpoVR family
KM398_04190	COG0446	pyridine nucleotide-disulphide oxidoreductase
KM398_04195	COG1937	Protein conserved in bacteria
KM398_04200	COG0425	Belongs to the sulfur carrier protein TusA family
KM398_04200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM398_04205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM398_04205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM398_04210	COG0425	Belongs to the sulfur carrier protein TusA family
KM398_04215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM398_04225	COG2210	Belongs to the sulfur carrier protein TusA family
KM398_04230	COG0730	response to heat
KM398_04240	COG1316	TRANSCRIPTIONal
KM398_04245	COG0604	alcohol dehydrogenase
KM398_04250	COG1283	sodium-dependent phosphate transmembrane transporter activity
KM398_04265	COG3711	transcriptional antiterminator
KM398_04265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM398_04270	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM398_04275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM398_04295	COG1388	LysM domain
KM398_04295	COG3584	3D domain protein
KM398_04300	COG0577	efflux transmembrane transporter activity
KM398_04305	COG1136	(ABC) transporter
KM398_04315	COG5522	Integral membrane protein (intg_mem_TP0381)
KM398_04330	COG1114	Component of the transport system for branched-chain amino acids
KM398_04335	COG3546	catalase activity
KM398_04370	COG0586	Pfam SNARE associated Golgi protein
KM398_04405	COG0531	amino acid
KM398_04410	COG0475	glutathione-regulated potassium exporter activity
KM398_04420	COG1737	Transcriptional regulator
KM398_04430	COG1263	PTS System
KM398_04430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM398_04440	COG2259	Doxx family
KM398_04455	COG0697	spore germination
KM398_04460	COG1522	sequence-specific DNA binding
KM398_04475	COG2076	Multidrug Resistance protein
KM398_04480	COG1309	transcriptional regulator
KM398_04485	COG2814	Major facilitator Superfamily
KM398_04490	COG1733	regulation of RNA biosynthetic process
KM398_04500	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM398_04505	COG4533	DNA binding
KM398_04510	COG2211	Major facilitator Superfamily
KM398_04520	COG0693	protein deglycase activity
KM398_04525	COG0693	protein deglycase activity
KM398_04525	COG0753	catalase activity
KM398_04535	COG0531	amino acid
KM398_04540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KM398_04550	COG1012	belongs to the aldehyde dehydrogenase family
KM398_04555	COG1132	(ABC) transporter
KM398_04565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM398_04570	COG0765	amino acid transport
KM398_04575	COG1126	abc transporter atp-binding protein
KM398_04590	COG0189	ligase activity
KM398_04620	COG0028	Belongs to the TPP enzyme family
KM398_04625	COG3527	Alpha-acetolactate decarboxylase
KM398_04640	COG0561	phosphatase activity
KM398_04655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM398_04670	COG0659	secondary active sulfate transmembrane transporter activity
KM398_04690	COG0653	protein targeting
KM398_04695	COG2244	polysaccharide biosynthetic process
KM398_04705	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM398_04710	COG4196	transglutaminase domain protein
KM398_04725	COG1696	Membrane protein involved in D-alanine export
KM398_04740	COG1024	Enoyl-CoA hydratase
KM398_04760	COG1363	Peptidase, m42
KM398_04780	COG3938	Belongs to the proline racemase family
KM398_04820	COG0601	transmembrane transport
KM398_04825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM398_04835	COG4608	Belongs to the ABC transporter superfamily
KM398_04840	COG0322	excinuclease ABC activity
KM398_04870	COG0477	Major facilitator Superfamily
KM398_04875	COG3290	protein histidine kinase activity
KM398_04880	COG4565	transcriptional regulatory protein
KM398_04885	COG3181	Tripartite tricarboxylate transporter family receptor
KM398_04915	COG0789	Transcriptional regulator
KM398_04915	COG4978	Transcriptional regulator
KM398_04930	COG0305	Participates in initiation and elongation during chromosome replication
KM398_04970	COG0477	Major facilitator Superfamily
KM398_05015	COG3320	Male sterility
KM398_05015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM398_05020	COG1309	transcriptional regulator
KM398_05040	COG1183	phosphatidylcholine synthase activity
KM398_05060	COG2376	Dihydroxyacetone kinase
KM398_05070	COG2376	Dihydroxyacetone kinase
KM398_05075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM398_05080	COG1959	2 iron, 2 sulfur cluster binding
KM398_05110	COG3437	response regulator, receiver
KM398_05110	COG2770	Histidine kinase
KM398_05160	COG3237	CsbD-like
KM398_05185	COG1191	sigma factor activity
KM398_05195	COG2208	phosphoserine phosphatase activity
KM398_05200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM398_05205	COG2205	protein histidine kinase activity
KM398_05205	COG0784	Response regulator, receiver
KM398_05205	COG2198	Histidine kinase
KM398_05205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM398_05260	COG0420	3'-5' exonuclease activity
KM398_05265	COG4717	serine-type aminopeptidase activity
KM398_05285	COG1309	transcriptional regulator
KM398_05290	COG2814	Major facilitator Superfamily
KM398_05295	COG0346	lactoylglutathione lyase activity
KM398_05305	COG0346	lactoylglutathione lyase activity
KM398_05310	COG0457	Tetratricopeptide repeat
KM398_05315	COG2267	carboxylic ester hydrolase activity
KM398_05335	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM398_05340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KM398_05350	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KM398_05390	COG0477	Major facilitator Superfamily
KM398_05395	COG0477	Major facilitator Superfamily
KM398_05405	COG3973	AAA domain
KM398_05410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM398_05430	COG4980	gas vesicle protein
KM398_05435	COG0537	adenosine 5'-monophosphoramidase activity
KM398_05440	COG1131	(ABC) transporter
KM398_05445	COG4473	ABC transporter
KM398_05460	COG1309	transcriptional regulator
KM398_05470	COG3402	PFAM membrane-flanked domain
KM398_05520	COG3402	PFAM membrane-flanked domain
KM398_05525	COG3428	Bacterial PH domain
KM398_05530	COG2329	Antibiotic biosynthesis monooxygenase
KM398_05535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM398_05540	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KM398_05545	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM398_05550	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM398_05585	COG1309	transcriptional regulator
KM398_05590	COG1511	domain protein
KM398_05615	COG1609	Transcriptional regulator
KM398_05625	COG1234	tRNA 3'-trailer cleavage
KM398_05630	COG0095	Lipoate-protein ligase
KM398_05640	COG0318	PFAM AMP-dependent synthetase and ligase
KM398_05670	COG3209	COG3209 Rhs family protein
KM398_05715	COG1078	dGTPase activity
KM398_05725	COG1595	DNA-templated transcription, initiation
KM398_05730	COG3708	Transcriptional regulator
KM398_05730	COG2207	Transcriptional regulator
KM398_05745	COG2205	protein histidine kinase activity
KM398_05750	COG0745	RESPONSE REGULATOR receiver
KM398_05775	COG0501	Belongs to the peptidase M48B family
KM398_05780	COG0840	transmembrane signaling receptor activity
KM398_05785	COG0697	spore germination
KM398_05805	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KM398_05810	COG2224	Isocitrate lyase
KM398_05835	COG4903	ComK protein
KM398_05840	COG0398	Pfam SNARE associated Golgi protein
KM398_05850	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KM398_05855	COG1074	ATP-dependent DNA helicase activity
KM398_05900	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM398_05925	COG0367	asparagine synthase
KM398_05930	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM398_05935	COG0753	catalase activity
KM398_05940	COG0004	ammonium transporteR
KM398_05960	COG2996	Protein conserved in bacteria
KM398_05970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM398_05980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM398_05995	COG0561	phosphatase activity
KM398_06005	COG0542	response to heat
KM398_06015	COG2267	carboxylic ester hydrolase activity
KM398_06030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM398_06035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KM398_06040	COG5504	Zn-dependent protease
KM398_06050	COG0180	Tryptophanyl-tRNA synthetase
KM398_06060	COG4166	transmembrane transport
KM398_06065	COG0601	transmembrane transport
KM398_06070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM398_06075	COG0444	Belongs to the ABC transporter superfamily
KM398_06080	COG4608	Belongs to the ABC transporter superfamily
KM398_06085	COG0534	Mate efflux family protein
KM398_06090	COG4166	transmembrane transport
KM398_06105	COG0861	Integral membrane protein TerC family
KM398_06110	COG4862	establishment of competence for transformation
KM398_06115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM398_06125	COG1164	Oligoendopeptidase f
KM398_06135	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM398_06140	COG2346	COG2346, Truncated hemoglobins
KM398_06145	COG4116	CYTH
KM398_06155	COG2357	RelA SpoT domain protein
KM398_06165	COG0564	pseudouridine synthase activity
KM398_06185	COG0463	Glycosyl transferase, family 2
KM398_06185	COG1216	Glycosyl transferase, family 2
KM398_06205	COG0457	Tetratricopeptide repeat
KM398_06205	COG0463	Glycosyl transferase, family 2
KM398_06225	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KM398_06240	COG1091	dTDP-4-dehydrorhamnose reductase activity
KM398_06285	COG2153	protein acetylation
KM398_06295	COG2382	esterase
KM398_06310	COG5492	domain, Protein
KM398_06315	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM398_06325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KM398_06325	COG0512	Glutamine amidotransferase of anthranilate synthase
KM398_06360	COG1620	l-lactate permease
KM398_06365	COG5634	Uncharacterized conserved protein (DUF2278)
KM398_06420	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM398_06430	COG1476	TRANSCRIPTIONal
KM398_06490	COG2226	methyltransferase
KM398_06500	COG1686	Belongs to the peptidase S11 family
KM398_06505	COG0681	Belongs to the peptidase S26 family
KM398_06540	COG1012	belongs to the aldehyde dehydrogenase family
KM398_06545	COG3842	ATPase activity
KM398_06550	COG1176	ABC-type spermidine putrescine transport system, permease component I
KM398_06555	COG1177	transmembrane transport
KM398_06560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KM398_06570	COG2409	Drug exporters of the RND superfamily
KM398_06580	COG0564	pseudouridine synthase activity
KM398_06590	COG2340	Cysteine-rich secretory protein family
KM398_06595	COG0247	lactate metabolic process
KM398_06600	COG0277	FAD linked oxidase domain protein
KM398_06605	COG3835	regulator
KM398_06615	COG0745	RESPONSE REGULATOR receiver
KM398_06620	COG5002	protein histidine kinase activity
KM398_06625	COG2186	Transcriptional regulator
KM398_06645	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KM398_06660	COG2116	formate transmembrane transporter activity
KM398_06665	COG0861	Integral membrane protein TerC family
KM398_06670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM398_06680	COG2030	dehydratase
KM398_06700	COG1028	Short-chain dehydrogenase reductase Sdr
KM398_06705	COG3243	poly(R)-hydroxyalkanoic acid synthase
KM398_06710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM398_06715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM398_06730	COG1840	ABC-type Fe3 transport system, periplasmic component
KM398_06760	COG1349	DNA-binding transcription factor activity
KM398_06780	COG2861	carbohydrate metabolic process
KM398_06790	COG3852	Histidine kinase
KM398_06795	COG1846	Transcriptional regulator
KM398_06805	COG2318	DinB family
KM398_06810	COG5002	protein histidine kinase activity
KM398_06820	COG0720	synthase
KM398_06835	COG4873	Protein conserved in bacteria
KM398_06865	COG1780	Probably involved in ribonucleotide reductase function
KM398_06885	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KM398_06890	COG1725	Transcriptional regulator
KM398_06895	COG1131	(ABC) transporter
KM398_06905	COG1131	(ABC) transporter
KM398_06910	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM398_06925	COG1522	sequence-specific DNA binding
KM398_06935	COG1335	isochorismatase
KM398_06945	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM398_06950	COG2070	2-Nitropropane dioxygenase
KM398_06955	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM398_06965	COG1696	Membrane protein involved in D-alanine export
KM398_06990	COG0716	FMN binding
KM398_07005	COG3173	Aminoglycoside phosphotransferase
KM398_07025	COG0534	Mate efflux family protein
KM398_07030	COG1968	undecaprenyl-diphosphatase activity
KM398_07045	COG1846	Transcriptional regulator
KM398_07055	COG1301	dicarboxylic acid transport
KM398_07060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM398_07065	COG4709	membrane
KM398_07070	COG3874	Sporulation protein YtfJ
KM398_07095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM398_07100	COG0028	Belongs to the TPP enzyme family
KM398_07105	COG0440	acetolactate synthase activity
KM398_07110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM398_07120	COG0473	3-isopropylmalate dehydrogenase activity
KM398_07145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KM398_07180	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM398_07195	COG1183	phosphatidylcholine synthase activity
KM398_07200	COG1368	sulfuric ester hydrolase activity
KM398_07210	COG0019	diaminopimelate decarboxylase activity
KM398_07230	COG0529	Catalyzes the synthesis of activated sulfate
KM398_07235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM398_07255	COG1648	precorrin-2 dehydrogenase activity
KM398_07260	COG0733	neurotransmitter:sodium symporter activity
KM398_07280	COG1757	Na H antiporter
KM398_07295	COG4758	membrane
KM398_07300	COG4585	Histidine kinase
KM398_07305	COG2197	response regulator
KM398_07315	COG1114	Component of the transport system for branched-chain amino acids
KM398_07325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KM398_07350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KM398_07350	COG1017	nitric oxide dioxygenase activity
KM398_07365	COG0730	response to heat
KM398_07370	COG0306	phosphate transporter
KM398_07375	COG1392	Phosphate transport regulator
KM398_07380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM398_07395	COG3852	Histidine kinase
KM398_07400	COG1801	Protein of unknown function DUF72
KM398_07410	COG0582	viral genome integration into host DNA
KM398_07415	COG5002	protein histidine kinase activity
KM398_07435	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KM398_07435	COG0392	lysyltransferase activity
KM398_07450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM398_07455	COG1686	Belongs to the peptidase S11 family
KM398_07460	COG2715	membrane protein required for spore maturation
KM398_07465	COG0700	Nucleoside recognition
KM398_07470	COG1187	pseudouridine synthase activity
KM398_07480	COG1333	cytochrome c biogenesis protein
KM398_07485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM398_07490	COG0745	RESPONSE REGULATOR receiver
KM398_07495	COG5002	protein histidine kinase activity
KM398_07500	COG2096	Adenosyltransferase
KM398_07515	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KM398_07520	COG1141	Ferredoxin
KM398_07525	COG4955	Helix-turn-helix domain
KM398_07530	COG0514	ATP-dependent DNA helicase (RecQ)
KM398_07535	COG1266	CAAX protease self-immunity
KM398_07555	COG4862	establishment of competence for transformation
KM398_07560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KM398_07580	COG0492	ferredoxin-NADP+ reductase activity
KM398_07655	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM398_07670	COG0142	geranyltranstransferase activity
KM398_07680	COG0142	geranyltranstransferase activity
KM398_07700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM398_07705	COG0457	Tetratricopeptide repeat
KM398_07725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KM398_07735	COG4347	Protein of unknown function (DUF1405)
KM398_07750	COG2738	Putative neutral zinc metallopeptidase
KM398_07760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM398_07765	COG1694	Mazg nucleotide pyrophosphohydrolase
KM398_07780	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM398_07785	COG0438	transferase activity, transferring glycosyl groups
KM398_07820	COG1199	ATP-dependent helicase activity
KM398_07820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KM398_07840	COG3935	DnaD domain protein
KM398_07845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KM398_07855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM398_07855	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM398_07915	COG0116	Belongs to the methyltransferase superfamily
KM398_07925	COG1199	ATP-dependent helicase activity
KM398_07930	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KM398_07940	COG3173	Aminoglycoside phosphotransferase
KM398_07945	COG0024	Methionine aminopeptidase
KM398_07955	COG2233	PERMEase
KM398_07960	COG2311	Membrane
KM398_07965	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM398_07975	COG0456	acetyltransferase
KM398_08025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM398_08050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KM398_08065	COG1215	transferase activity, transferring glycosyl groups
KM398_08070	COG0438	transferase activity, transferring glycosyl groups
KM398_08085	COG0454	-acetyltransferase
KM398_08105	COG0328	RNA-DNA hybrid ribonuclease activity
KM398_08145	COG1280	lysine exporter protein (LysE YggA)
KM398_08160	COG3162	membrane
KM398_08165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM398_08170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM398_08180	COG0475	glutathione-regulated potassium exporter activity
KM398_08185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM398_08190	COG0789	Transcriptional regulator
KM398_08190	COG4978	Transcriptional regulator
KM398_08200	COG2323	membrane
KM398_08205	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KM398_08260	COG1923	regulation of RNA biosynthetic process
KM398_08270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM398_08275	COG1360	Flagellar Motor Protein
KM398_08280	COG2201	protein-glutamate methylesterase activity
KM398_08285	COG0643	Histidine kinase
KM398_08285	COG2198	Histidine kinase
KM398_08290	COG2198	Histidine kinase
KM398_08290	COG0643	Histidine kinase
KM398_08295	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM398_08295	COG1776	CheC inhibitor of MCP methylation
KM398_08310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM398_08330	COG1256	bacterial-type flagellum assembly
KM398_08355	COG1815	bacterial-type flagellum-dependent cell motility
KM398_08360	COG1558	bacterial-type flagellum-dependent cell motility
KM398_08375	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM398_08385	COG1157	protein secretion by the type III secretion system
KM398_08425	COG0784	Response regulator, receiver
KM398_08425	COG0835	chemotaxis
KM398_08435	COG0463	Glycosyl transferase, family 2
KM398_08470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KM398_08475	COG0741	lytic transglycosylase activity
KM398_08490	COG1776	CheC inhibitor of MCP methylation
KM398_08490	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM398_08500	COG1338	Plays a role in the flagellum-specific transport system
KM398_08505	COG1987	bacterial-type flagellum assembly
KM398_08515	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM398_08520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM398_08525	COG1419	protein localization to endoplasmic reticulum
KM398_08530	COG4786	Flagellar basal body rod
KM398_08535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM398_08560	COG1309	transcriptional regulator
KM398_08580	COG2329	Antibiotic biosynthesis monooxygenase
KM398_08605	COG0583	DNA-binding transcription factor activity
KM398_08610	COG3842	ATPase activity
KM398_08615	COG0725	ABC transporter, periplasmic molybdate-binding protein
KM398_08625	COG1234	tRNA 3'-trailer cleavage
KM398_08650	COG1686	Belongs to the peptidase S11 family
KM398_08660	COG0406	alpha-ribazole phosphatase activity
KM398_08690	COG0367	asparagine synthase
KM398_08720	COG1802	Transcriptional regulator
KM398_08725	COG0697	spore germination
KM398_08730	COG0523	cobalamin synthesis protein
KM398_08735	COG0701	Predicted permease
KM398_08745	COG1216	Glycosyl transferase, family 2
KM398_08745	COG0438	transferase activity, transferring glycosyl groups
KM398_08750	COG1757	Na H antiporter
KM398_08755	COG0114	fumarate hydratase activity
KM398_08780	COG3340	Belongs to the peptidase S51 family
KM398_08800	COG0785	Cytochrome C biogenesis protein
KM398_08830	COG2733	membrane
KM398_08865	COG1131	(ABC) transporter
KM398_08880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM398_08885	COG0528	UMP kinase activity
KM398_08895	COG1027	Aspartate ammonia-lyase
KM398_08900	COG0281	malic enzyme
KM398_08905	COG4191	Histidine kinase
KM398_08910	COG0784	Response regulator, receiver
KM398_08915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM398_08970	COG1051	belongs to the nudix hydrolase family
KM398_08975	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM398_08985	COG2814	Major facilitator Superfamily
KM398_09000	COG1966	Carbon starvation protein
KM398_09015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM398_09025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KM398_09035	COG2223	nitrite transmembrane transporter activity
KM398_09040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM398_09055	COG2244	polysaccharide biosynthetic process
KM398_09060	COG0733	neurotransmitter:sodium symporter activity
KM398_09070	COG5566	PFAM Mor transcription activator
KM398_09075	COG2323	membrane
KM398_09090	COG2084	Dehydrogenase
KM398_09105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM398_09115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM398_09120	COG0028	Belongs to the TPP enzyme family
KM398_09125	COG0440	acetolactate synthase activity
KM398_09130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM398_09140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KM398_09165	COG2814	Major facilitator Superfamily
KM398_09170	COG3384	dioxygenase
KM398_09180	COG3279	Response regulator of the LytR AlgR family
KM398_09185	COG0427	acetyl-CoA hydrolase
KM398_09205	COG1073	alpha beta
KM398_09235	COG0535	radical SAM domain protein
KM398_09240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM398_09260	COG1914	H( )-stimulated, divalent metal cation uptake system
KM398_09275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM398_09305	COG2390	Transcriptional regulator
KM398_09315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM398_09320	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KM398_09335	COG4224	UPF0291 protein
KM398_09355	COG0006	proline dipeptidase activity
KM398_09360	COG2132	Multicopper oxidase
KM398_09375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM398_09390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM398_09405	COG2372	response to copper ion
KM398_09405	COG1276	copper resistance
KM398_09410	COG4549	nuclear export factor GLE1
KM398_09420	COG0697	spore germination
KM398_09425	COG0583	DNA-binding transcription factor activity
KM398_09430	COG1959	2 iron, 2 sulfur cluster binding
KM398_09435	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM398_09440	COG0778	Nitroreductase
KM398_09450	COG0628	permease
KM398_09460	COG1231	oxidoreductase activity
KM398_09465	COG0523	cobalamin synthesis protein
KM398_09480	COG0318	PFAM AMP-dependent synthetase and ligase
KM398_09485	COG2030	dehydratase
KM398_09490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM398_09500	COG0411	ABC transporter
KM398_09520	COG0583	DNA-binding transcription factor activity
KM398_09530	COG1942	4-Oxalocrotonate Tautomerase
KM398_09540	COG1846	Transcriptional regulator
KM398_09550	COG1271	oxidase subunit
KM398_09555	COG1294	oxidase, subunit
KM398_09560	COG4988	ABC transporter
KM398_09565	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KM398_09585	COG1686	Belongs to the peptidase S11 family
KM398_09600	COG1388	LysM domain
KM398_09600	COG0791	NLP P60 protein
KM398_09615	COG0745	RESPONSE REGULATOR receiver
KM398_09620	COG5002	protein histidine kinase activity
KM398_09630	COG0300	oxidoreductase activity
KM398_09665	COG0460	homoserine dehydrogenase
KM398_09690	COG1316	TRANSCRIPTIONal
KM398_09700	COG0745	RESPONSE REGULATOR receiver
KM398_09705	COG5002	protein histidine kinase activity
KM398_09720	COG1285	pathogenesis
KM398_09725	COG1247	-acetyltransferase
KM398_09745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM398_09755	COG1082	Xylose isomerase domain protein TIM barrel
KM398_09770	COG1279	arginine transmembrane transporter activity
KM398_09780	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM398_09820	COG2002	toxin-antitoxin pair type II binding
KM398_09825	COG1404	Belongs to the peptidase S8 family
KM398_09830	COG0640	Transcriptional regulator
KM398_09835	COG0667	Aldo Keto reductase
KM398_09840	COG2814	Major facilitator Superfamily
KM398_09865	COG0840	transmembrane signaling receptor activity
KM398_09880	COG3949	Membrane
KM398_09885	COG0783	Belongs to the Dps family
KM398_09900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM398_09910	COG1231	oxidoreductase activity
KM398_09920	COG4989	oxidoreductase activity
KM398_09925	COG0523	cobalamin synthesis protein
KM398_09930	COG0456	acetyltransferase
KM398_09985	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM398_09985	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM398_09995	COG0702	epimerase
KM398_10005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM398_10015	COG4166	transmembrane transport
KM398_10030	COG0406	alpha-ribazole phosphatase activity
KM398_10040	COG5337	Spore coat protein CotH
KM398_10045	COG1051	belongs to the nudix hydrolase family
KM398_10050	COG0586	Pfam SNARE associated Golgi protein
KM398_10055	COG2244	polysaccharide biosynthetic process
KM398_10065	COG0701	Predicted permease
KM398_10070	COG3689	TIGRFAM TIGR03943 family protein
KM398_10075	COG1607	acyl-coa hydrolase
KM398_10085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM398_10100	COG0702	epimerase
KM398_10105	COG2839	Protein conserved in bacteria
KM398_10110	COG1253	flavin adenine dinucleotide binding
KM398_10125	COG1114	Component of the transport system for branched-chain amino acids
KM398_10130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM398_10150	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM398_10160	COG1876	peptidase activity
KM398_10170	COG0154	amidase activity
KM398_10175	COG2211	Major facilitator Superfamily
KM398_10195	COG0561	phosphatase activity
KM398_10205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM398_10210	COG4106	trans-aconitate 2-methyltransferase activity
KM398_10225	COG1819	glycosyl
KM398_10230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM398_10235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM398_10260	COG0456	acetyltransferase
KM398_10310	COG3874	Sporulation protein YtfJ
KM398_10335	COG2226	methyltransferase
KM398_10360	COG0346	lactoylglutathione lyase activity
KM398_10370	COG0604	alcohol dehydrogenase
KM398_10375	COG1595	DNA-templated transcription, initiation
KM398_10400	COG0386	Belongs to the glutathione peroxidase family
KM398_10405	COG1305	Transglutaminase-like
KM398_10410	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KM398_10415	COG0714	Associated with various cellular activities
KM398_10430	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KM398_10435	COG1140	nitrate reductase beta subunit
KM398_10440	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KM398_10445	COG2181	nitrate reductase activity
KM398_10465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM398_10470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KM398_10475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM398_10480	COG0303	'Molybdopterin
KM398_10485	COG0314	molybdopterin synthase activity
KM398_10495	COG2223	nitrite transmembrane transporter activity
KM398_10510	COG1648	precorrin-2 dehydrogenase activity
KM398_10520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KM398_10520	COG1587	Uroporphyrinogen-III synthase
KM398_10525	COG2146	nitrite reductase [NAD(P)H] activity
KM398_10530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM398_10535	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KM398_10570	COG2359	stage V sporulation protein S
KM398_10585	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM398_10600	COG1418	mRNA catabolic process
KM398_10605	COG0488	(ABC) transporter
KM398_10620	COG0629	single-stranded DNA binding
KM398_10635	COG1413	lyase activity
KM398_10650	COG2521	methyltransferase
KM398_10650	COG2136	Putative SAM-dependent methyltransferase
KM398_10655	COG0018	arginyl-trna synthetase
KM398_10680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KM398_10700	COG0017	Asparaginyl-tRNA synthetase
KM398_10720	COG1674	ftsk spoiiie
KM398_10790	COG1929	Belongs to the glycerate kinase type-1 family
KM398_10795	COG0471	metal ion transport
KM398_10800	COG0745	RESPONSE REGULATOR receiver
KM398_10805	COG5002	protein histidine kinase activity
KM398_10805	COG3850	Histidine kinase
KM398_10820	COG0733	neurotransmitter:sodium symporter activity
KM398_10845	COG2610	gluconate transmembrane transporter activity
KM398_10850	COG1454	alcohol dehydrogenase
KM398_10855	COG1794	racemase activity, acting on amino acids and derivatives
KM398_10865	COG0456	acetyltransferase
KM398_10880	COG1131	(ABC) transporter
KM398_10895	COG0546	phosphoglycolate phosphatase activity
KM398_10915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM398_10930	COG0768	penicillin binding
KM398_10935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM398_10940	COG0204	Acyl-transferase
KM398_10945	COG1272	protein, Hemolysin III
KM398_10955	COG0805	protein transport
KM398_10965	COG1307	EDD domain protein, DegV family
KM398_10970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KM398_10975	COG1999	signal sequence binding
KM398_10980	COG0071	Belongs to the small heat shock protein (HSP20) family
KM398_10985	COG0367	asparagine synthase
KM398_11000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM398_11005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM398_11030	COG1051	belongs to the nudix hydrolase family
KM398_11040	COG0668	transmembrane transport
KM398_11045	COG2203	Gaf domain
KM398_11045	COG4585	Histidine kinase
KM398_11050	COG2197	response regulator
KM398_11060	COG1064	alcohol dehydrogenase
KM398_11085	COG1070	Carbohydrate kinase
KM398_11090	COG1070	Carbohydrate kinase
KM398_11120	COG1125	glycine betaine transport
KM398_11120	COG0517	IMP dehydrogenase activity
KM398_11125	COG1174	glycine betaine transport
KM398_11160	COG1253	flavin adenine dinucleotide binding
KM398_11165	COG1012	belongs to the aldehyde dehydrogenase family
KM398_11170	COG5506	Protein of unknown function (DUF1694)
KM398_11185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM398_11190	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KM398_11195	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KM398_11200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM398_11205	COG0456	acetyltransferase
KM398_11210	COG3829	transcription factor binding
KM398_11215	COG1509	lysine 2,3-aminomutase activity
KM398_11255	COG4326	sporulation control protein
KM398_11260	COG0671	phosphoesterase, PA-phosphatase related
KM398_11265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM398_11270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM398_11300	COG1715	Restriction endonuclease
KM398_11300	COG1787	Restriction endonuclease
KM398_11390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM398_11430	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM398_11430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM398_11435	COG2814	Major facilitator Superfamily
KM398_11440	COG4841	protein insertion into membrane
KM398_11445	COG0372	Belongs to the citrate synthase family
KM398_11450	COG2079	MmgE PrpD family protein
KM398_11455	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KM398_11460	COG1960	acyl-CoA dehydrogenase activity
KM398_11465	COG2084	Dehydrogenase
KM398_11475	COG1280	lysine exporter protein (LysE YggA)
KM398_11480	COG1024	Enoyl-CoA hydratase
KM398_11495	COG0420	3'-5' exonuclease activity
KM398_11500	COG0419	ATPase involved in DNA repair
KM398_11525	COG2223	nitrite transmembrane transporter activity
KM398_11530	COG1028	Short-chain dehydrogenase reductase Sdr
KM398_11535	COG1169	isochorismate synthase
KM398_11540	COG1021	2,3-dihydroxybenzoate-AMP ligase
KM398_11545	COG3433	isochorismatase activity
KM398_11545	COG1535	isochorismatase
KM398_11550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KM398_11555	COG3251	PFAM MbtH domain protein
KM398_11560	COG2814	Major facilitator Superfamily
KM398_11575	COG0776	regulation of translation
KM398_11585	COG2318	DinB family
KM398_11595	COG1115	amino acid carrier protein
KM398_11610	COG2329	Antibiotic biosynthesis monooxygenase
KM398_11615	COG1187	pseudouridine synthase activity
KM398_11620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM398_11635	COG0596	Alpha beta hydrolase
KM398_11640	COG2814	Major facilitator Superfamily
KM398_11660	COG2226	methyltransferase
KM398_11705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM398_11740	COG1247	-acetyltransferase
KM398_11770	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM398_11780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM398_11790	COG1278	Cold shock
KM398_11805	COG0010	Belongs to the arginase family
KM398_11810	COG0561	phosphatase activity
KM398_11855	COG0583	DNA-binding transcription factor activity
KM398_11860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM398_11875	COG0583	DNA-binding transcription factor activity
KM398_11880	COG2258	MOSC domain
KM398_11895	COG1132	(ABC) transporter
KM398_11900	COG1132	(ABC) transporter
KM398_11920	COG1396	sequence-specific DNA binding
KM398_11945	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
KM398_11950	COG1595	DNA-templated transcription, initiation
KM398_11975	COG1649	PFAM Uncharacterised BCR, COG1649
KM398_12000	COG2971	BadF BadG BcrA BcrD
KM398_12005	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM398_12010	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KM398_12030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM398_12060	COG1309	transcriptional regulator
KM398_12075	COG0577	efflux transmembrane transporter activity
KM398_12075	COG1136	(ABC) transporter
KM398_12080	COG0500	methyltransferase
KM398_12080	COG3615	Tellurite resistance protein tehB
KM398_12090	COG2226	methyltransferase
KM398_12095	COG3961	Belongs to the TPP enzyme family
KM398_12100	COG1846	Transcriptional regulator
KM398_12140	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM398_12155	COG1595	DNA-templated transcription, initiation
KM398_12165	COG0768	penicillin binding
KM398_12175	COG2367	Beta-lactamase
KM398_12180	COG0671	phosphoesterase, PA-phosphatase related
KM398_12185	COG1609	Transcriptional regulator
KM398_12190	COG2814	Major facilitator Superfamily
KM398_12195	COG0673	inositol 2-dehydrogenase activity
KM398_12205	COG1012	belongs to the aldehyde dehydrogenase family
KM398_12220	COG0191	fructose-bisphosphate aldolase activity
KM398_12225	COG3718	enzyme involved in inositol metabolism
KM398_12250	COG0457	Tetratricopeptide repeat
KM398_12255	COG1476	TRANSCRIPTIONal
KM398_12270	COG1876	peptidase activity
KM398_12290	COG1309	transcriptional regulator
KM398_12295	COG0488	(ABC) transporter
KM398_12310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM398_12325	COG1252	NADH dehydrogenase
KM398_12330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM398_12345	COG1131	(ABC) transporter
KM398_12355	COG1309	transcriptional regulator
KM398_12370	COG1960	acyl-CoA dehydrogenase activity
KM398_12375	COG0439	Biotin carboxylase
KM398_12380	COG0511	ligase activity, forming carbon-carbon bonds
KM398_12385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KM398_12390	COG1024	Enoyl-CoA hydratase
KM398_12395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KM398_12400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM398_12410	COG1247	-acetyltransferase
KM398_12415	COG0572	uridine kinase
KM398_12425	COG2318	DinB family
KM398_12430	COG1686	Belongs to the peptidase S11 family
KM398_12455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KM398_12495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM398_12495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM398_12520	COG2814	Major facilitator Superfamily
KM398_12540	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM398_12560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM398_12575	COG1063	alcohol dehydrogenase
KM398_12605	COG3773	Cell wall hydrolase
KM398_12615	COG0745	RESPONSE REGULATOR receiver
KM398_12630	COG0488	(ABC) transporter
KM398_12645	COG1136	(ABC) transporter
KM398_12670	COG0460	homoserine dehydrogenase
KM398_12675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM398_12685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM398_12750	COG2124	cytochrome p450
KM398_12785	COG0561	phosphatase activity
KM398_12795	COG5002	protein histidine kinase activity
KM398_12800	COG0768	penicillin binding
KM398_12805	COG1819	glycosyl
KM398_12810	COG1794	racemase activity, acting on amino acids and derivatives
KM398_12820	COG1122	ATPase activity
KM398_12835	COG2205	protein histidine kinase activity
KM398_12845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM398_12850	COG0604	alcohol dehydrogenase
KM398_12855	COG0768	penicillin binding
KM398_12865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM398_12900	COG0693	protein deglycase activity
KM398_12930	COG2814	Major facilitator Superfamily
KM398_12945	COG0584	glycerophosphoryl diester phosphodiesterase
KM398_12965	COG0697	spore germination
KM398_12990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM398_13000	COG2223	nitrite transmembrane transporter activity
KM398_13015	COG2816	NAD+ diphosphatase activity
KM398_13020	COG0592	DNA-directed DNA polymerase activity
KM398_13025	COG1051	belongs to the nudix hydrolase family
KM398_13060	COG3878	Protein conserved in bacteria
KM398_13105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM398_13120	COG0322	excinuclease ABC activity
KM398_13165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM398_13190	COG1011	Hydrolase
KM398_13210	COG0076	glutamate decarboxylase activity
KM398_13225	COG1523	belongs to the glycosyl hydrolase 13 family
KM398_13230	COG3227	Zinc metalloprotease (Elastase)
KM398_13250	COG0201	protein transport
KM398_13260	COG0697	spore germination
KM398_13265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM398_13295	COG4129	membrane
KM398_13300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM398_13315	COG2959	enzyme of heme biosynthesis
KM398_13335	COG3483	tryptophan 2,3-dioxygenase activity
KM398_13340	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KM398_13345	COG3844	kynureninase activity
KM398_13350	COG1309	transcriptional regulator
KM398_13380	COG3284	Transcriptional regulator
KM398_13400	COG1349	DNA-binding transcription factor activity
KM398_13420	COG1959	2 iron, 2 sulfur cluster binding
KM398_13435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM398_13440	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM398_13445	COG0022	dehydrogenase e1 component
KM398_13450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM398_13460	COG1028	Short-chain dehydrogenase reductase Sdr
KM398_13465	COG0456	acetyltransferase
KM398_13465	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM398_13495	COG4176	ABC-type proline glycine betaine transport system permease component
KM398_13500	COG4175	Glycine betaine
KM398_13500	COG0517	IMP dehydrogenase activity
KM398_13525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KM398_13530	COG2153	protein acetylation
KM398_13535	COG3397	chitin binding
KM398_13550	COG2205	protein histidine kinase activity
KM398_13575	COG0658	competence protein
KM398_13575	COG2333	competence protein COMEC
KM398_13625	COG3973	AAA domain
KM398_13640	COG2105	PFAM AIG2 family protein
KM398_13645	COG0514	ATP-dependent DNA helicase (RecQ)
KM398_13665	COG4637	Psort location Cytoplasmic, score
KM398_13690	COG3397	chitin binding
KM398_13705	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KM398_13710	COG1115	amino acid carrier protein
KM398_13715	COG1012	belongs to the aldehyde dehydrogenase family
KM398_13720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KM398_13730	COG3938	Belongs to the proline racemase family
KM398_13735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM398_13775	COG0586	Pfam SNARE associated Golgi protein
KM398_13790	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM398_13795	COG0519	Catalyzes the synthesis of GMP from XMP
KM398_13800	COG4166	transmembrane transport
KM398_13810	COG4948	Mandelate Racemase Muconate Lactonizing
KM398_13855	COG2936	dipeptidyl-peptidase activity
KM398_13860	COG5002	protein histidine kinase activity
KM398_13900	COG1164	Oligoendopeptidase f
KM398_13915	COG1307	EDD domain protein, DegV family
KM398_13935	COG2814	Major facilitator Superfamily
KM398_13945	COG1664	Polymer-forming cytoskeletal
KM398_13950	COG0789	Transcriptional regulator
KM398_13955	COG4533	DNA binding
KM398_13960	COG0477	Major facilitator Superfamily
KM398_13960	COG2814	Major facilitator Superfamily
KM398_13980	COG2261	transglycosylase associated protein
KM398_13995	COG2226	methyltransferase
KM398_14030	COG0436	Aminotransferase
KM398_14035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KM398_14040	COG5146	pantothenate kinase activity
KM398_14060	COG1131	(ABC) transporter
KM398_14105	COG0628	permease
KM398_14115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM398_14120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM398_14125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM398_14130	COG1116	anion transmembrane transporter activity
KM398_14150	COG2816	NAD+ diphosphatase activity
KM398_14170	COG2746	aminoglycoside 3-N-acetyltransferase activity
KM398_14195	COG0697	spore germination
KM398_14200	COG2318	DinB family
KM398_14220	COG4912	Dna alkylation repair
KM398_14240	COG0861	Integral membrane protein TerC family
KM398_14245	COG1368	sulfuric ester hydrolase activity
KM398_14250	COG0488	(ABC) transporter
KM398_14260	COG1033	growth of symbiont in host cell
KM398_14260	COG2409	Drug exporters of the RND superfamily
KM398_14265	COG1033	growth of symbiont in host cell
KM398_14265	COG2409	Drug exporters of the RND superfamily
KM398_14270	COG2409	Drug exporters of the RND superfamily
KM398_14270	COG1033	growth of symbiont in host cell
KM398_14275	COG1309	transcriptional regulator
KM398_14290	COG0287	Prephenate dehydrogenase
KM398_14295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM398_14300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KM398_14305	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KM398_14305	COG1605	Chorismate mutase
KM398_14340	COG3584	3D domain protein
KM398_14340	COG1388	LysM domain
KM398_14350	COG1595	DNA-templated transcription, initiation
KM398_14375	COG1879	ABC-type sugar transport system periplasmic component
KM398_14385	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM398_14395	COG2390	Transcriptional regulator
KM398_14430	COG2329	Antibiotic biosynthesis monooxygenase
KM398_14450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM398_14460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KM398_14465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM398_14470	COG4187	Peptidase family M20/M25/M40
KM398_14475	COG1414	Transcriptional regulator
KM398_14480	COG0833	amino acid
KM398_14485	COG1690	Belongs to the RtcB family
KM398_14490	COG3239	Fatty acid desaturase
KM398_14495	COG1785	Belongs to the alkaline phosphatase family
KM398_14505	COG3655	Transcriptional regulator
KM398_14520	COG4377	Putative membrane peptidase family (DUF2324)
KM398_14530	COG3279	Response regulator of the LytR AlgR family
KM398_14540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM398_14545	COG0346	lactoylglutathione lyase activity
KM398_14565	COG0714	Associated with various cellular activities
KM398_14615	COG0463	Glycosyl transferase, family 2
KM398_14625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM398_14630	COG0753	catalase activity
KM398_14640	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KM398_14665	COG0714	Associated with various cellular activities
KM398_14675	COG0778	Nitroreductase
KM398_14680	COG1846	Transcriptional regulator
KM398_14715	COG1725	Transcriptional regulator
KM398_14725	COG1136	(ABC) transporter
KM398_14725	COG0577	efflux transmembrane transporter activity
KM398_14750	COG2207	Transcriptional regulator
KM398_14755	COG0456	acetyltransferase
KM398_14775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM398_14795	COG0642	Histidine kinase
KM398_14800	COG0745	RESPONSE REGULATOR receiver
KM398_14805	COG0596	Alpha beta hydrolase
KM398_14835	COG0730	response to heat
KM398_14845	COG0833	amino acid
KM398_14855	COG4335	DNA alkylation repair
KM398_14895	COG0768	penicillin binding
KM398_14905	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KM398_14935	COG1984	allophanate hydrolase subunit 2
KM398_14940	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KM398_14945	COG1414	Transcriptional regulator
KM398_14960	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM398_14965	COG0640	Transcriptional regulator
KM398_14975	COG1960	acyl-CoA dehydrogenase activity
KM398_14995	COG3314	Sporulation integral membrane protein YlbJ
KM398_15010	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KM398_15025	COG3848	Pyruvate phosphate dikinase
KM398_15025	COG0574	Belongs to the PEP-utilizing enzyme family
KM398_15030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM398_15045	COG5577	PFAM Coat F domain
KM398_15050	COG3403	YqcI/YcgG family
KM398_15055	COG1280	lysine exporter protein (LysE YggA)
KM398_15090	COG1063	alcohol dehydrogenase
KM398_15105	COG1027	Aspartate ammonia-lyase
KM398_15110	COG0252	asparaginase activity
KM398_15115	COG1396	sequence-specific DNA binding
KM398_15125	COG0322	excinuclease ABC activity
KM398_15130	COG0531	amino acid
KM398_15135	COG1114	Component of the transport system for branched-chain amino acids
KM398_15140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM398_15150	COG0281	malic enzyme
KM398_15165	COG0531	amino acid
KM398_15175	COG0784	Response regulator, receiver
KM398_15185	COG2066	Belongs to the glutaminase family
KM398_15190	COG1115	amino acid carrier protein
KM398_15220	COG0737	Belongs to the 5'-nucleotidase family
KM398_15225	COG0753	catalase activity
KM398_15230	COG2267	carboxylic ester hydrolase activity
KM398_15235	COG1335	isochorismatase
KM398_15255	COG0583	DNA-binding transcription factor activity
KM398_15260	COG1846	Transcriptional regulator
KM398_15300	COG0415	Belongs to the DNA photolyase family
KM398_15305	COG0288	reversible hydration of carbon dioxide
KM398_15315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM398_15320	COG5609	conserved protein (DUF2294)
KM398_15335	COG1575	Belongs to the MenA family. Type 1 subfamily
KM398_15340	COG2267	carboxylic ester hydrolase activity
KM398_15345	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM398_15350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM398_15355	COG1121	(ABC) transporter
KM398_15385	COG0798	PFAM Bile acid sodium symporter
KM398_15390	COG0346	lactoylglutathione lyase activity
KM398_15395	COG0640	Transcriptional regulator
KM398_15410	COG0443	Heat shock 70 kDa protein
KM398_15425	COG1522	sequence-specific DNA binding
KM398_15440	COG0346	lactoylglutathione lyase activity
KM398_15465	COG2169	Transcriptional regulator
KM398_15510	COG2814	Major facilitator Superfamily
KM398_15535	COG0745	RESPONSE REGULATOR receiver
KM398_15540	COG5002	protein histidine kinase activity
KM398_15540	COG3850	Histidine kinase
KM398_15565	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KM398_15585	COG1476	TRANSCRIPTIONal
KM398_15600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM398_15605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM398_15615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM398_15620	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KM398_15635	COG1136	(ABC) transporter
KM398_15640	COG0577	efflux transmembrane transporter activity
KM398_15655	COG5002	protein histidine kinase activity
KM398_15655	COG3850	Histidine kinase
KM398_15665	COG2364	Membrane
KM398_15670	COG1846	Transcriptional regulator
KM398_15680	COG2808	Putative FMN-binding domain
KM398_15685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM398_15690	COG2271	Major facilitator Superfamily
KM398_15695	COG1556	Lactate utilization protein
KM398_15700	COG1139	Iron-sulfur cluster binding protein
KM398_15710	COG0583	DNA-binding transcription factor activity
KM398_15720	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM398_15745	COG0738	Major facilitator superfamily
KM398_15750	COG0673	inositol 2-dehydrogenase activity
KM398_15755	COG0561	phosphatase activity
KM398_15765	COG1609	Transcriptional regulator
KM398_15770	COG0457	Tetratricopeptide repeat
KM398_15790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM398_15820	COG0534	Mate efflux family protein
KM398_15840	COG2814	Major facilitator Superfamily
KM398_15845	COG1309	transcriptional regulator
KM398_15860	COG0814	amino acid
KM398_15865	COG1760	l-serine dehydratase
KM398_15870	COG1760	l-serine dehydratase
KM398_15880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM398_15885	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KM398_15895	COG1335	isochorismatase
KM398_15900	COG1522	sequence-specific DNA binding
KM398_15905	COG0531	amino acid
KM398_15920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KM398_15940	COG1595	DNA-templated transcription, initiation
KM398_15955	COG0662	Cupin 2, conserved barrel domain protein
KM398_15960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM398_15960	COG2207	Transcriptional regulator
KM398_16010	COG0477	Major facilitator Superfamily
KM398_16020	COG1846	Transcriptional regulator
KM398_16025	COG2814	Major facilitator Superfamily
KM398_16035	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM398_16040	COG1131	(ABC) transporter
KM398_16060	COG2076	Multidrug Resistance protein
KM398_16065	COG1309	transcriptional regulator
KM398_16075	COG2031	fatty acid transporter
KM398_16085	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM398_16115	COG1122	ATPase activity
KM398_16120	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM398_16135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KM398_16140	COG1288	antiporter activity
KM398_16145	COG2356	endonuclease I
KM398_16160	COG3620	sequence-specific DNA binding
KM398_16165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM398_16170	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KM398_16175	COG0124	histidyl-tRNA synthetase
KM398_16190	COG1733	regulation of RNA biosynthetic process
KM398_16195	COG0778	Nitroreductase
KM398_16215	COG1028	Short-chain dehydrogenase reductase Sdr
KM398_16225	COG1131	(ABC) transporter
KM398_16250	COG1011	Hydrolase
KM398_16260	COG2365	Tyrosine phosphatase family
KM398_16285	COG0346	lactoylglutathione lyase activity
KM398_16290	COG1940	carbohydrate kinase activity
KM398_16295	COG0738	Major facilitator superfamily
KM398_16300	COG0110	maltose O-acetyltransferase activity
KM398_16310	COG0577	efflux transmembrane transporter activity
KM398_16310	COG1136	(ABC) transporter
KM398_16325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KM398_16330	COG0628	permease
KM398_16350	COG2226	methyltransferase
KM398_16360	COG0477	Major facilitator Superfamily
KM398_16390	COG1253	flavin adenine dinucleotide binding
KM398_16395	COG0789	Transcriptional regulator
KM398_16400	COG0697	spore germination
KM398_16405	COG1357	PFAM Pentapeptide repeats (8 copies)
KM398_16410	COG3813	Protein conserved in bacteria
KM398_16415	COG2706	6-phosphogluconolactonase activity
KM398_16420	COG1070	Carbohydrate kinase
KM398_16430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KM398_16435	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KM398_16445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM398_16450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM398_16455	COG0604	alcohol dehydrogenase
KM398_16460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM398_16470	COG3321	synthase
KM398_16470	COG0604	alcohol dehydrogenase
KM398_16475	COG1028	Short-chain dehydrogenase reductase Sdr
KM398_16500	COG0656	L-ascorbic acid biosynthetic process
KM398_16505	COG2814	Major facilitator Superfamily
KM398_16520	COG0346	lactoylglutathione lyase activity
KM398_16525	COG0814	amino acid
KM398_16550	COG1393	Belongs to the ArsC family
KM398_16555	COG1733	regulation of RNA biosynthetic process
KM398_16560	COG2188	Transcriptional regulator
KM398_16570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KM398_16575	COG1733	regulation of RNA biosynthetic process
KM398_16580	COG1733	regulation of RNA biosynthetic process
KM398_16595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM398_16615	COG0384	phenazine biosynthesis protein PhzF
KM398_16625	COG1028	Short-chain dehydrogenase reductase Sdr
KM398_16635	COG0318	PFAM AMP-dependent synthetase and ligase
KM398_16645	COG1733	regulation of RNA biosynthetic process
KM398_16680	COG1191	sigma factor activity
KM398_16695	COG1309	transcriptional regulator
KM398_16715	COG3152	Membrane
KM398_16740	COG1151	hydroxylamine reductase activity
KM398_16750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM398_16755	COG3757	hydrolase, family 25
KM398_16755	COG3409	Peptidoglycan-binding domain 1 protein
KM398_16790	COG2072	flavoprotein involved in K transport
KM398_16825	COG0604	alcohol dehydrogenase
KM398_16830	COG1113	amino acid transport
KM398_16835	COG2814	Major facilitator Superfamily
KM398_16865	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM398_16870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM398_16890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM398_16895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM398_16900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM398_16905	COG3739	integral membrane protein
KM398_16910	COG0384	phenazine biosynthesis protein PhzF
KM398_16940	COG0583	DNA-binding transcription factor activity
KM398_16960	COG1193	negative regulation of DNA recombination
KM398_16985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM398_17015	COG0584	glycerophosphoryl diester phosphodiesterase
KM398_17040	COG0640	Transcriptional regulator
KM398_17045	COG0604	alcohol dehydrogenase
KM398_17065	COG2808	Putative FMN-binding domain
KM398_17070	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM398_17080	COG0385	Bile acid
KM398_17085	COG0277	FAD linked oxidase domain protein
KM398_17115	COG1216	Glycosyl transferase, family 2
KM398_17120	COG1024	Enoyl-CoA hydratase
KM398_17130	COG1285	pathogenesis
KM398_17145	COG2514	catechol 2,3-dioxygenase activity
KM398_17150	COG2720	vancomycin resistance protein
KM398_17190	COG0716	FMN binding
KM398_17220	COG1028	Short-chain dehydrogenase reductase Sdr
KM398_17230	COG0165	Argininosuccinate lyase
KM398_17245	COG4145	pantothenate transmembrane transporter activity
KM398_17255	COG1012	belongs to the aldehyde dehydrogenase family
KM398_17260	COG1028	Short-chain dehydrogenase reductase Sdr
KM398_17270	COG1657	PFAM Prenyltransferase squalene oxidase
KM398_17275	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KM398_17280	COG2962	Rard protein
KM398_17285	COG3326	Membrane
KM398_17300	COG0489	protein tyrosine kinase activity
KM398_17310	COG0314	molybdopterin synthase activity
KM398_17315	COG0303	'Molybdopterin
KM398_17320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM398_17325	COG2116	formate transmembrane transporter activity
KM398_17335	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM398_17340	COG5609	conserved protein (DUF2294)
KM398_17345	COG2427	Protein of unknown function (DUF1641)
KM398_17350	COG3383	formate dehydrogenase (NAD+) activity
KM398_17355	COG0697	spore germination
KM398_17395	COG2226	methyltransferase
KM398_17400	COG4166	transmembrane transport
KM398_17405	COG4166	transmembrane transport
KM398_17410	COG4166	transmembrane transport
KM398_17415	COG1301	dicarboxylic acid transport
KM398_17420	COG1316	TRANSCRIPTIONal
KM398_17430	COG1595	DNA-templated transcription, initiation
KM398_17450	COG1131	(ABC) transporter
KM398_17460	COG0673	inositol 2-dehydrogenase activity
KM398_17465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM398_17470	COG0187	DNA topoisomerase II activity
KM398_17475	COG1832	CoA-binding protein
KM398_17480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM398_17485	COG0745	RESPONSE REGULATOR receiver
KM398_17500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM398_17505	COG4841	protein insertion into membrane
KM398_17510	COG0824	Thioesterase
KM398_17540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM398_17550	COG2274	protein secretion by the type I secretion system
KM398_17555	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KM398_17595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM398_17610	COG0183	Belongs to the thiolase family
KM398_17615	COG0318	PFAM AMP-dependent synthetase and ligase
KM398_17620	COG1268	BioY protein
KM398_17625	COG0318	PFAM AMP-dependent synthetase and ligase
KM398_17675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM398_17685	COG5002	protein histidine kinase activity
KM398_17690	COG0400	carboxylic ester hydrolase activity
KM398_17695	COG0346	lactoylglutathione lyase activity
KM398_17700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM398_17705	COG0069	glutamate synthase activity
KM398_17710	COG1902	pentaerythritol trinitrate reductase activity
KM398_17715	COG1329	Transcriptional regulator
KM398_17720	COG0010	Belongs to the arginase family
KM398_17745	COG2226	methyltransferase
KM398_17800	COG4846	Membrane protein involved in cytochrome C biogenesis
KM398_17805	COG0785	Cytochrome C biogenesis protein
KM398_17815	COG0583	DNA-binding transcription factor activity
KM398_17820	COG1380	Effector of murein hydrolase LrgA
KM398_17825	COG1346	cytolysis
KM398_17850	COG3409	Peptidoglycan-binding domain 1 protein
KM398_17850	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM398_17865	COG1132	(ABC) transporter
KM398_17870	COG1132	(ABC) transporter
KM398_17900	COG3639	organic phosphonate transmembrane transporter activity
KM398_17905	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KM398_17925	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KM398_17945	COG1695	Transcriptional regulator
KM398_17985	COG3409	Peptidoglycan-binding domain 1 protein
KM398_17985	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM398_17985	COG1388	LysM domain
KM398_17990	COG4824	toxin secretion phage lysis holin
KM398_18145	COG1595	DNA-templated transcription, initiation
KM398_18190	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KM398_18275	COG1396	sequence-specific DNA binding
KM398_18300	COG0174	glutamine synthetase
KM398_18305	COG0789	Transcriptional regulator
KM398_18310	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KM398_18320	COG2860	membrane
KM398_18330	COG0464	growth
KM398_18360	COG3584	3D domain protein
KM398_18360	COG1388	LysM domain
KM398_18365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM398_18365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM398_18365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM398_18370	COG1105	Belongs to the carbohydrate kinase PfkB family
KM398_18375	COG1349	DNA-binding transcription factor activity
KM398_18385	COG2322	membrane
KM398_18395	COG1113	amino acid transport
KM398_18410	COG1408	metallophosphoesterase
KM398_18415	COG2116	formate transmembrane transporter activity
KM398_18430	COG2608	mercury ion transmembrane transporter activity
KM398_18435	COG1937	Protein conserved in bacteria
KM398_18445	COG2819	hydrolase of the alpha beta superfamily
KM398_18450	COG1120	ATPase activity
KM398_18455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM398_18460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM398_18470	COG0708	Exodeoxyribonuclease III
KM398_18475	COG2169	Transcriptional regulator
KM398_18480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM398_18485	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM398_18495	COG2364	Membrane
KM398_18510	COG2267	carboxylic ester hydrolase activity
KM398_18515	COG0346	lactoylglutathione lyase activity
KM398_18520	COG3300	MHYT domain
KM398_18520	COG5001	Diguanylate cyclase
KM398_18535	COG1346	cytolysis
KM398_18540	COG1380	Effector of murein hydrolase LrgA
KM398_18545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM398_18550	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM398_18550	COG0596	Alpha beta hydrolase
KM398_18555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM398_18575	COG1404	Belongs to the peptidase S8 family
KM398_18580	COG3773	Cell wall hydrolase
KM398_18585	COG0562	UDP-galactopyranose mutase
KM398_18590	COG1368	sulfuric ester hydrolase activity
KM398_18595	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM398_18605	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KM398_18630	COG1131	(ABC) transporter
KM398_18650	COG4550	Control of competence regulator ComK, YlbF/YmcA
KM398_18655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM398_18660	COG1013	pyruvate-flavodoxin oxidoreductase activity
KM398_18665	COG0674	pyruvate-flavodoxin oxidoreductase activity
KM398_18665	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KM398_18675	COG2359	stage V sporulation protein S
KM398_18680	COG1692	metallophosphoesterase
KM398_18705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KM398_18710	COG1426	Protein conserved in bacteria
KM398_18725	COG0300	oxidoreductase activity
KM398_18730	COG0612	Peptidase, M16
KM398_18735	COG0612	Peptidase, M16
KM398_18740	COG1079	Belongs to the binding-protein-dependent transport system permease family
KM398_18750	COG3845	ABC transporter
KM398_18755	COG1744	ABC transporter substrate-binding protein PnrA-like
KM398_18760	COG2188	Transcriptional regulator
KM398_18765	COG1674	ftsk spoiiie
KM398_18775	COG0740	serine-type endopeptidase activity
KM398_18780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM398_18790	COG0527	aspartate kinase activity
KM398_18795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM398_18800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM398_18805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM398_18810	COG1873	PFAM PRC-barrel domain
KM398_18815	COG0612	Peptidase, M16
KM398_18820	COG0726	polysaccharide deacetylase
KM398_18835	COG0196	riboflavin kinase activity
KM398_18840	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KM398_18850	COG1550	Protein conserved in bacteria
KM398_18860	COG1358	cellular component organization or biogenesis
KM398_18865	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KM398_18870	COG0195	Participates in both transcription termination and antitermination
KM398_18890	COG0750	zinc metalloprotease
KM398_18900	COG4589	Belongs to the CDS family
KM398_18905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KM398_18915	COG0528	UMP kinase activity
KM398_18945	COG4974	Belongs to the 'phage' integrase family
KM398_18955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM398_18965	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KM398_19005	COG1837	Belongs to the UPF0109 family
KM398_19015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KM398_19025	COG0552	protein localization to endoplasmic reticulum
KM398_19030	COG1196	nuclear chromosome segregation
KM398_19040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM398_19045	COG1028	Short-chain dehydrogenase reductase Sdr
KM398_19050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KM398_19065	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KM398_19070	COG1461	Dihydroxyacetone kinase
KM398_19075	COG1302	Protein conserved in bacteria
KM398_19090	COG1564	THIamine pyrophosphokinase
KM398_19095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KM398_19100	COG1162	GTPase activity
KM398_19105	COG0515	serine threonine protein kinase
KM398_19105	COG2815	serine threonine protein kinase
KM398_19110	COG0631	protein serine/threonine phosphatase activity
KM398_19120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KM398_19120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KM398_19130	COG0242	peptide deformylase activity
KM398_19135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KM398_19140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM398_19160	COG1561	YicC-like family, N-terminal region
KM398_19165	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KM398_19175	COG0006	proline dipeptidase activity
KM398_19190	COG3069	C4-dicarboxylate transmembrane transporter activity
KM398_19255	COG0564	pseudouridine synthase activity
KM398_19275	COG3599	regulation of cell shape
KM398_19280	COG2302	S4 RNA-binding domain
KM398_19285	COG0762	integral membrane protein
KM398_19295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KM398_19300	COG1496	oxidoreductase activity
KM398_19305	COG1873	PFAM PRC-barrel domain
KM398_19310	COG1191	sigma factor activity
KM398_19315	COG1191	sigma factor activity
KM398_19325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KM398_19330	COG0849	cell division
KM398_19335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KM398_19340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM398_19350	COG0772	Belongs to the SEDS family
KM398_19365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KM398_19370	COG0768	penicillin binding
KM398_19375	COG0768	penicillin binding
KM398_19380	COG4839	cell division protein FtsL
KM398_19395	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM398_19410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KM398_19415	COG1399	metal-binding, possibly nucleic acid-binding protein
KM398_19465	COG4824	toxin secretion phage lysis holin
KM398_19550	COG4626	Terminase
KM398_19550	COG1802	Transcriptional regulator
KM398_19575	COG0582	viral genome integration into host DNA
KM398_19640	COG0756	dUTP diphosphatase activity
KM398_19655	COG1191	sigma factor activity
KM398_19680	COG1484	DNA-dependent DNA replication
KM398_19710	COG1396	sequence-specific DNA binding
KM398_19725	COG1396	sequence-specific DNA binding
KM398_19740	COG0582	viral genome integration into host DNA
KM398_19750	COG3480	Lon protease (S16) C-terminal proteolytic domain
KM398_19755	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM398_19760	COG3314	Sporulation integral membrane protein YlbJ
KM398_19770	COG0742	ribosomal rna small subunit methyltransferase
KM398_19785	COG3679	Belongs to the UPF0342 family
KM398_19790	COG0406	alpha-ribazole phosphatase activity
KM398_19805	COG2340	Cysteine-rich secretory protein family
KM398_19820	COG3336	cytochrome c oxidase
KM398_19855	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KM398_19860	COG0772	Belongs to the SEDS family
KM398_19870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KM398_19875	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KM398_19885	COG4896	Protein conserved in bacteria
KM398_19900	COG1217	gtp-binding protein TYPA
KM398_19910	COG0483	inositol monophosphate 1-phosphatase activity
KM398_19930	COG1982	Orn Lys Arg decarboxylase major
KM398_19975	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM398_19980	COG0022	dehydrogenase e1 component
KM398_19985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM398_19995	COG0242	peptide deformylase activity
KM398_20000	COG0561	phosphatase activity
KM398_20010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM398_20015	COG0569	domain protein
KM398_20035	COG0583	DNA-binding transcription factor activity
KM398_20040	COG0517	IMP dehydrogenase activity
KM398_20050	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
KM398_20060	COG4703	Protein of unknown function (DUF1797)
KM398_20075	COG2200	EAL domain
KM398_20080	COG1028	Short-chain dehydrogenase reductase Sdr
KM398_20085	COG1408	metallophosphoesterase
KM398_20095	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KM398_20130	COG2814	Major facilitator Superfamily
KM398_20150	COG3209	COG3209 Rhs family protein
KM398_20160	COG2205	protein histidine kinase activity
KM398_20170	COG0436	Aminotransferase
KM398_20175	COG1609	Transcriptional regulator
KM398_20180	COG3833	ABC-type maltose transport systems, permease component
KM398_20185	COG1175	transmembrane transport
KM398_20190	COG2182	Extracellular solute-binding protein
KM398_20200	COG0366	Alpha amylase catalytic
KM398_20205	COG3842	ATPase activity
KM398_20245	COG0183	Belongs to the thiolase family
KM398_20280	COG1695	Transcriptional regulator
KM398_20285	COG1028	Short-chain dehydrogenase reductase Sdr
KM398_20295	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KM398_20305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KM398_20310	COG0436	Aminotransferase
KM398_20330	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KM398_20350	COG2199	diguanylate cyclase activity
KM398_20355	COG0778	Nitroreductase
KM398_20380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM398_20380	COG2190	(PTS) system
KM398_20380	COG1263	PTS System
KM398_20385	COG3711	transcriptional antiterminator
KM398_20395	COG2188	Transcriptional regulator
KM398_20405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KM398_20430	COG1547	Domain of unknown function (DUF309)
KM398_20435	COG0456	acetyltransferase
KM398_20440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KM398_20445	COG4086	secreted protein
KM398_20450	COG0561	phosphatase activity
KM398_20455	COG0697	spore germination
KM398_20470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM398_20495	COG0733	neurotransmitter:sodium symporter activity
KM398_20515	COG1686	Belongs to the peptidase S11 family
KM398_20520	COG1725	Transcriptional regulator
KM398_20525	COG1131	(ABC) transporter
KM398_20540	COG1846	Transcriptional regulator
KM398_20555	COG0598	Magnesium transport protein CorA
KM398_20580	COG4974	Belongs to the 'phage' integrase family
KM398_20590	COG0735	belongs to the Fur family
KM398_20595	COG1300	Membrane
KM398_20615	COG0667	Aldo Keto reductase
KM398_20620	COG0656	L-ascorbic acid biosynthetic process
KM398_20625	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM398_20625	COG0456	acetyltransferase
KM398_20635	COG0737	Belongs to the 5'-nucleotidase family
KM398_20635	COG1525	nuclease
KM398_20635	COG4085	toxin activity
KM398_20645	COG0596	Alpha beta hydrolase
KM398_20650	COG2056	Na+-H+ antiporter family
KM398_20655	COG1609	Transcriptional regulator
KM398_20660	COG0456	acetyltransferase
KM398_20665	COG1073	alpha beta
KM398_20680	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM398_20680	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM398_20685	COG0307	riboflavin synthase, alpha
KM398_20710	COG4106	trans-aconitate 2-methyltransferase activity
KM398_20715	COG2226	methyltransferase
KM398_20715	COG1073	alpha beta
KM398_20730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM398_20740	COG1757	Na H antiporter
KM398_20745	COG0737	Belongs to the 5'-nucleotidase family
KM398_20755	COG1522	sequence-specific DNA binding
KM398_20775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM398_20785	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KM398_20800	COG0300	oxidoreductase activity
KM398_20810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM398_20815	COG1760	l-serine dehydratase
KM398_20820	COG1760	l-serine dehydratase
KM398_20840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM398_20850	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM398_20855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM398_20870	COG1376	ErfK ybiS ycfS ynhG family protein
KM398_20875	COG4129	membrane
KM398_20880	COG1126	abc transporter atp-binding protein
KM398_20885	COG0765	amino acid transport
KM398_20890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM398_20910	COG0772	Belongs to the SEDS family
KM398_20915	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM398_20920	COG0022	dehydrogenase e1 component
KM398_20925	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM398_20930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM398_20945	COG0280	phosphate acetyltransferase
KM398_20950	COG3829	transcription factor binding
KM398_20950	COG3290	protein histidine kinase activity
KM398_20960	COG0584	glycerophosphoryl diester phosphodiesterase
KM398_20965	COG3093	addiction module antidote protein HigA
KM398_20975	COG0745	RESPONSE REGULATOR receiver
KM398_20980	COG0750	zinc metalloprotease
KM398_20985	COG0497	DNA recombination
KM398_20995	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KM398_21005	COG0142	geranyltranstransferase activity
KM398_21030	COG1302	Protein conserved in bacteria
KM398_21035	COG0439	Biotin carboxylase
KM398_21040	COG0511	ligase activity, forming carbon-carbon bonds
KM398_21085	COG3854	ATPases associated with a variety of cellular activities
KM398_21110	COG0006	proline dipeptidase activity
KM398_21125	COG3872	metal-dependent enzyme
KM398_21135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KM398_21155	COG0095	Lipoate-protein ligase
KM398_21160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM398_21165	COG1609	Transcriptional regulator
KM398_21175	COG2076	Multidrug Resistance protein
KM398_21180	COG2076	Multidrug Resistance protein
KM398_21215	COG1131	(ABC) transporter
KM398_21220	COG1725	Transcriptional regulator
KM398_21250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM398_21305	COG4970	Tfp pilus assembly protein FimT
KM398_21315	COG1459	type II secretion system
KM398_21320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KM398_21370	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KM398_21375	COG1410	methionine synthase
KM398_21375	COG0646	methionine synthase
KM398_21380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KM398_21380	COG0646	methionine synthase
KM398_21385	COG0626	cystathionine gamma-synthase activity
KM398_21390	COG0626	cystathionine gamma-synthase activity
KM398_21410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM398_21420	COG1940	carbohydrate kinase activity
KM398_21425	COG4483	Protein conserved in bacteria
KM398_21430	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KM398_21435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KM398_21440	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KM398_21445	COG0704	Plays a role in the regulation of phosphate uptake
KM398_21455	COG0581	inorganic phosphate transmembrane transporter activity
KM398_21460	COG0573	inorganic phosphate transmembrane transporter activity
KM398_21465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM398_21470	COG0768	penicillin binding
KM398_21475	COG0477	Major facilitator Superfamily
KM398_21480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM398_21505	COG0735	belongs to the Fur family
KM398_21510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM398_21515	COG1121	(ABC) transporter
KM398_21520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM398_21550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM398_21555	COG2384	SAM-dependent methyltransferase
KM398_21560	COG2010	Cytochrome c
KM398_21565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM398_21570	COG0358	DNA primase activity
KM398_21580	COG0517	IMP dehydrogenase activity
KM398_21595	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KM398_21600	COG0295	cytidine deaminase activity
KM398_21605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KM398_21615	COG1480	7TM receptor with intracellular HD hydrolase
KM398_21620	COG1702	phosphate starvation-inducible protein PhoH
KM398_21635	COG1610	YqeY-like protein
KM398_21640	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KM398_21645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM398_21650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KM398_21680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM398_21685	COG1733	regulation of RNA biosynthetic process
KM398_21710	COG1466	dna polymerase III delta subunit
KM398_21720	COG0658	competence protein
KM398_21720	COG2333	competence protein COMEC
KM398_21725	COG2131	deaminase
KM398_21730	COG1596	polysaccharide export
KM398_21730	COG1555	photosystem II stabilization
KM398_21735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM398_21740	COG2226	methyltransferase
KM398_21745	COG0799	negative regulation of ribosome biogenesis
KM398_21750	COG1713	HD superfamily hydrolase involved in NAD metabolism
KM398_21760	COG1534	Rna-binding protein
KM398_21770	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KM398_21775	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KM398_21800	COG1595	DNA-templated transcription, initiation
KM398_21810	COG0778	Nitroreductase
KM398_21815	COG2357	RelA SpoT domain protein
KM398_21825	COG1785	Belongs to the alkaline phosphatase family
KM398_21835	COG2267	carboxylic ester hydrolase activity
KM398_21870	COG1404	Belongs to the peptidase S8 family
KM398_21875	COG3186	Phenylalanine-4-hydroxylase
KM398_21890	COG2259	Doxx family
KM398_21930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM398_21940	COG1454	alcohol dehydrogenase
KM398_21940	COG1012	belongs to the aldehyde dehydrogenase family
KM398_21945	COG0626	cystathionine gamma-synthase activity
KM398_21950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM398_21975	COG0768	penicillin binding
KM398_21990	COG0826	peptidase U32
KM398_21995	COG0826	peptidase U32
KM398_22000	COG4122	O-methyltransferase activity
KM398_22005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KM398_22025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM398_22035	COG0628	permease
KM398_22055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KM398_22065	COG0482	sulfurtransferase activity
KM398_22070	COG1104	cysteine desulfurase activity
KM398_22075	COG1959	2 iron, 2 sulfur cluster binding
KM398_22080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KM398_22090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KM398_22115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KM398_22125	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KM398_22125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KM398_22130	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM398_22135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM398_22135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM398_22145	COG2244	polysaccharide biosynthetic process
KM398_22150	COG2323	membrane
KM398_22160	COG1862	Preprotein translocase
KM398_22190	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KM398_22200	COG0697	spore germination
KM398_22205	COG0697	spore germination
KM398_22210	COG0640	Transcriptional regulator
KM398_22235	COG0157	Belongs to the NadC ModD family
KM398_22240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KM398_22245	COG1104	cysteine desulfurase activity
KM398_22250	COG1827	regulation of RNA biosynthetic process
KM398_22255	COG2258	MOSC domain
KM398_22260	COG0077	Prephenate dehydratase
KM398_22265	COG0577	efflux transmembrane transporter activity
KM398_22270	COG0577	efflux transmembrane transporter activity
KM398_22275	COG1136	(ABC) transporter
KM398_22285	COG0745	RESPONSE REGULATOR receiver
KM398_22290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KM398_22295	COG3290	protein histidine kinase activity
KM398_22305	COG2868	ribosomal protein
KM398_22315	COG1530	ribonuclease E activity
KM398_22320	COG1994	Peptidase M50
KM398_22325	COG0739	heme binding
KM398_22330	COG2894	cell division
KM398_22350	COG1077	Cell shape determining protein MreB Mrl
KM398_22370	COG0285	dihydrofolate synthase activity
KM398_22375	COG0525	valine-tRNA ligase activity
KM398_22385	COG1388	LysM domain
KM398_22395	COG0113	porphobilinogen synthase activity
KM398_22400	COG1587	Uroporphyrinogen-III synthase
KM398_22410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM398_22420	COG1846	Transcriptional regulator
KM398_22425	COG1764	response to oxidative stress
KM398_22440	COG0470	DNA polymerase III
KM398_22440	COG1067	ATP-dependent peptidase activity
KM398_22485	COG0622	Phosphoesterase
KM398_22500	COG5401	PFAM Sporulation and spore germination
KM398_22520	COG1309	transcriptional regulator
KM398_22535	COG2197	response regulator
KM398_22540	COG2233	PERMEase
KM398_22550	COG0402	S-adenosylhomocysteine deaminase activity
KM398_22555	COG0402	S-adenosylhomocysteine deaminase activity
KM398_22565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM398_22575	COG0444	Belongs to the ABC transporter superfamily
KM398_22580	COG4608	Belongs to the ABC transporter superfamily
KM398_22585	COG3275	phosphorelay sensor kinase activity
KM398_22590	COG3279	Response regulator of the LytR AlgR family
KM398_22605	COG1983	PspC domain protein
KM398_22610	COG1396	sequence-specific DNA binding
KM398_22615	COG0697	spore germination
KM398_22625	COG1959	2 iron, 2 sulfur cluster binding
KM398_22630	COG1668	transmembrane transport
KM398_22635	COG4152	abc transporter atp-binding protein
KM398_22640	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KM398_22650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM398_22655	COG1876	peptidase activity
KM398_22660	COG0824	Thioesterase
KM398_22665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KM398_22670	COG1053	succinate dehydrogenase
KM398_22675	COG2009	succinate dehydrogenase
KM398_22680	COG1719	4-vinyl reductase, 4VR
KM398_22690	COG3118	belongs to the thioredoxin family
KM398_22695	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KM398_22700	COG2086	electron transfer activity
KM398_22705	COG1024	Enoyl-CoA hydratase
KM398_22710	COG1309	transcriptional regulator
KM398_22715	COG0318	PFAM AMP-dependent synthetase and ligase
KM398_22735	COG2318	DinB family
KM398_22765	COG1131	(ABC) transporter
KM398_22770	COG2205	protein histidine kinase activity
KM398_22775	COG0745	RESPONSE REGULATOR receiver
KM398_22785	COG4895	conserved protein (DUF2196)
KM398_22790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KM398_22805	COG4509	Sortase family
KM398_22810	COG1120	ATPase activity
KM398_22825	COG5386	Cell surface protein
KM398_22835	COG5386	Cell surface protein
KM398_22840	COG1114	Component of the transport system for branched-chain amino acids
KM398_22845	COG1187	pseudouridine synthase activity
KM398_22855	COG1796	DNA polymerase
KM398_22855	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM398_22860	COG1286	toxin biosynthetic process
KM398_22905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM398_22915	COG1418	mRNA catabolic process
KM398_22940	COG2814	Major facilitator Superfamily
KM398_22945	COG1566	PFAM secretion protein HlyD family protein
KM398_22950	COG1309	transcriptional regulator
KM398_22955	COG1363	Peptidase, m42
KM398_22980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM398_22990	COG1484	DNA-dependent DNA replication
KM398_22995	COG3611	Membrane attachment protein
KM398_23005	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM398_23010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM398_23015	COG0237	dephospho-CoA kinase activity
KM398_23020	COG1971	Probably functions as a manganese efflux pump
KM398_23030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM398_23030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM398_23035	COG5002	protein histidine kinase activity
KM398_23040	COG0745	RESPONSE REGULATOR receiver
KM398_23060	COG0538	isocitrate dehydrogenase activity
KM398_23065	COG0372	Belongs to the citrate synthase family
KM398_23075	COG0628	permease
KM398_23080	COG3030	protein affecting phage T7 exclusion by the F plasmid
KM398_23105	COG1725	Transcriptional regulator
KM398_23110	COG0281	malic enzyme
KM398_23115	COG0587	DNA-directed DNA polymerase activity
KM398_23130	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KM398_23150	COG4109	DRTGG domain
KM398_23165	COG0006	proline dipeptidase activity
KM398_23200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM398_23205	COG0662	Cupin 2, conserved barrel domain protein
KM398_23215	COG1476	TRANSCRIPTIONal
KM398_23230	COG1028	Short-chain dehydrogenase reductase Sdr
KM398_23235	COG0589	response to stress
KM398_23275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM398_23295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KM398_23300	COG0827	DNA restriction-modification system
KM398_23305	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KM398_23310	COG3874	Sporulation protein YtfJ
KM398_23325	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KM398_23335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM398_23350	COG1104	cysteine desulfurase activity
KM398_23360	COG0583	DNA-binding transcription factor activity
KM398_23365	COG0697	spore germination
KM398_23375	COG1956	GAF domain-containing protein
KM398_23380	COG0626	cystathionine gamma-synthase activity
KM398_23410	COG1595	DNA-templated transcription, initiation
KM398_23420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM398_23425	COG0454	-acetyltransferase
KM398_23430	COG0517	IMP dehydrogenase activity
KM398_23435	COG0123	including yeast histone deacetylase and acetoin utilization protein
KM398_23445	COG0745	RESPONSE REGULATOR receiver
KM398_23455	COG0666	response to abiotic stimulus
KM398_23490	COG1609	Transcriptional regulator
KM398_23495	COG4851	CamS sex pheromone cAM373 precursor
KM398_23500	COG3118	belongs to the thioredoxin family
KM398_23510	COG2309	aminopeptidase activity
KM398_23530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM398_23545	COG1674	ftsk spoiiie
KM398_23555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM398_23560	COG4848	Belongs to the UPF0354 family
KM398_23565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM398_23570	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
KM398_23575	COG1363	Peptidase, m42
KM398_23585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM398_23600	COG0510	thiamine kinase activity
KM398_23605	COG1523	belongs to the glycosyl hydrolase 13 family
KM398_23620	COG1349	DNA-binding transcription factor activity
KM398_23625	COG1187	pseudouridine synthase activity
KM398_23630	COG2244	polysaccharide biosynthetic process
KM398_23635	COG2081	HI0933 family
KM398_23640	COG2814	Major facilitator Superfamily
KM398_23650	COG3832	glyoxalase III activity
KM398_23670	COG1329	Transcriptional regulator
KM398_23680	COG4975	Glucose uptake
KM398_23695	COG0314	molybdopterin synthase activity
KM398_23700	COG1763	Mo-molybdopterin cofactor biosynthetic process
KM398_23705	COG0303	'Molybdopterin
KM398_23715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM398_23740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM398_23750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM398_23795	COG2814	Major facilitator Superfamily
KM398_23800	COG0475	glutathione-regulated potassium exporter activity
KM398_23805	COG0490	domain, Protein
KM398_23810	COG0582	viral genome integration into host DNA
KM398_23820	COG1136	(ABC) transporter
KM398_23840	COG1242	4 iron, 4 sulfur cluster binding
KM398_23845	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KM398_23850	COG1131	(ABC) transporter
KM398_23860	COG1794	racemase activity, acting on amino acids and derivatives
KM398_23880	COG2267	carboxylic ester hydrolase activity
KM398_23885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KM398_23890	COG0671	phosphoesterase, PA-phosphatase related
KM398_23895	COG0438	transferase activity, transferring glycosyl groups
KM398_23905	COG0521	Mo-molybdopterin cofactor biosynthetic process
KM398_23960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM398_23965	COG5002	protein histidine kinase activity
KM398_23970	COG4191	Histidine kinase
KM398_23975	COG2267	carboxylic ester hydrolase activity
KM398_23995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM398_24000	COG1116	anion transmembrane transporter activity
KM398_24005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM398_24030	COG0494	nUDIX hydrolase
KM398_24060	COG0288	reversible hydration of carbon dioxide
KM398_24065	COG1271	oxidase subunit
KM398_24070	COG1294	oxidase, subunit
KM398_24090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM398_24115	COG1842	Phage shock protein A
KM398_24145	COG5002	protein histidine kinase activity
KM398_24150	COG0745	RESPONSE REGULATOR receiver
KM398_24180	COG1597	lipid kinase activity
KM398_24215	COG0586	Pfam SNARE associated Golgi protein
KM398_24225	COG0577	efflux transmembrane transporter activity
KM398_24230	COG1136	(ABC) transporter
KM398_24235	COG3708	Transcriptional regulator
KM398_24235	COG2207	Transcriptional regulator
KM398_24240	COG0745	RESPONSE REGULATOR receiver
KM398_24245	COG2205	protein histidine kinase activity
KM398_24250	COG0577	efflux transmembrane transporter activity
KM398_24260	COG0577	efflux transmembrane transporter activity
KM398_24265	COG1136	(ABC) transporter
KM398_24285	COG2188	Transcriptional regulator
KM398_24305	COG3964	amidohydrolase
KM398_24335	COG4948	Mandelate Racemase Muconate Lactonizing
KM398_24345	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KM398_24350	COG0596	Alpha beta hydrolase
KM398_24355	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KM398_24360	COG1169	isochorismate synthase
KM398_24365	COG1575	Belongs to the MenA family. Type 1 subfamily
KM398_24370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KM398_24390	COG0058	SHG alpha-glucan phosphorylase activity
KM398_24395	COG0297	glycogen (starch) synthase activity
KM398_24400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KM398_24520	COG0544	peptidyl-prolyl cis-trans isomerase activity
KM398_24555	COG1285	pathogenesis
KM398_24560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM398_24570	COG0166	Belongs to the GPI family
KM398_24575	COG2155	Conserved Protein
KM398_24580	COG1098	S1 RNA binding domain
KM398_24585	COG0436	Aminotransferase
KM398_24590	COG1522	sequence-specific DNA binding
KM398_24595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM398_24600	COG2267	carboxylic ester hydrolase activity
KM398_24610	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KM398_24630	COG5018	Exonuclease
KM398_24635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM398_24655	COG2050	protein possibly involved in aromatic compounds catabolism
KM398_24665	COG1268	BioY protein
KM398_24675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM398_24680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KM398_24695	COG3584	3D domain protein
KM398_24710	COG1252	NADH dehydrogenase
KM398_24725	COG3708	Transcriptional regulator
KM398_24740	COG1683	Conserved Protein
KM398_24760	COG0316	Belongs to the HesB IscA family
KM398_24775	COG1252	NADH dehydrogenase
KM398_24790	COG0390	transport system, permease component
KM398_24795	COG2824	Alkylphosphonate utilization operon protein PhnA
KM398_24835	COG4837	Protein of unknown function (DUF1462)
KM398_24840	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KM398_24850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM398_24855	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KM398_24865	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM398_24870	COG0647	UMP catabolic process
KM398_24880	COG2445	Protein of unknown function DUF86
KM398_24885	COG1494	fructose-1,6-bisphosphatase
KM398_24900	COG4470	Protein conserved in bacteria
KM398_24910	COG0789	Transcriptional regulator
KM398_24915	COG4377	Putative membrane peptidase family (DUF2324)
KM398_24940	COG0739	heme binding
KM398_24950	COG3377	Domain of unknown function (DUF1805)
KM398_24955	COG0737	Belongs to the 5'-nucleotidase family
KM398_24960	COG1695	Transcriptional regulator
KM398_24970	COG0719	Fe-S assembly protein
KM398_24975	COG0822	iron-sulfur transferase activity
KM398_24980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KM398_24985	COG0719	Fe-S assembly protein
KM398_24990	COG0396	ATPase activity
KM398_24995	COG1464	Belongs to the NlpA lipoprotein family
KM398_25000	COG1464	Belongs to the NlpA lipoprotein family
KM398_25005	COG2011	ABC-type metal ion transport system permease component
KM398_25010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM398_25020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM398_25025	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM398_25035	COG1393	Belongs to the ArsC family
KM398_25080	COG0039	L-malate dehydrogenase activity
KM398_25100	COG1309	transcriptional regulator
KM398_25105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM398_25110	COG1960	acyl-CoA dehydrogenase activity
KM398_25115	COG0183	Belongs to the thiolase family
KM398_25120	COG1024	Enoyl-CoA hydratase
KM398_25120	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM398_25130	COG1686	Belongs to the peptidase S11 family
KM398_25145	COG0011	TIGRFAM Protein of
KM398_25150	COG0840	transmembrane signaling receptor activity
KM398_25170	COG2814	Major facilitator Superfamily
KM398_25175	COG0531	amino acid
KM398_25185	COG0706	membrane insertase activity
KM398_25195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM398_25230	COG0586	Pfam SNARE associated Golgi protein
KM398_25240	COG1376	ErfK ybiS ycfS ynhG family protein
KM398_25245	COG0745	RESPONSE REGULATOR receiver
KM398_25250	COG5002	protein histidine kinase activity
KM398_25275	COG2151	metal-sulfur cluster biosynthetic enzyme
KM398_25280	COG3227	Zinc metalloprotease (Elastase)
KM398_25285	COG1741	Belongs to the pirin family
KM398_25300	COG0475	glutathione-regulated potassium exporter activity
KM398_25305	COG0490	domain, Protein
KM398_25310	COG1115	amino acid carrier protein
KM398_25315	COG0783	Belongs to the Dps family
KM398_25330	COG1611	Belongs to the LOG family
KM398_25350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM398_25355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM398_25360	COG1115	amino acid carrier protein
KM398_25365	COG1115	amino acid carrier protein
KM398_25370	COG2910	NAD(P)H-binding
KM398_25385	COG0656	L-ascorbic acid biosynthetic process
KM398_25390	COG2814	Major facilitator Superfamily
KM398_25395	COG1733	regulation of RNA biosynthetic process
KM398_25405	COG1252	NADH dehydrogenase
KM398_25410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KM398_25415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM398_25425	COG0840	transmembrane signaling receptor activity
KM398_25425	COG3290	protein histidine kinase activity
KM398_25435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM398_25440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM398_25455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM398_25510	COG0557	exoribonuclease II activity
KM398_25515	COG1647	Serine aminopeptidase, S33
KM398_25520	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM398_25525	COG1346	cytolysis
KM398_25625	COG4695	Portal protein
KM398_25650	COG4974	Belongs to the 'phage' integrase family
KM398_25660	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KM398_25665	COG0149	triose-phosphate isomerase activity
KM398_25675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM398_25690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KM398_25715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM398_25730	COG2323	membrane
KM398_25735	COG0740	serine-type endopeptidase activity
KM398_25740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM398_25750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KM398_25760	COG1051	belongs to the nudix hydrolase family
KM398_25770	COG0492	ferredoxin-NADP+ reductase activity
KM398_25775	COG0457	Tetratricopeptide repeat
KM398_25780	COG0110	maltose O-acetyltransferase activity
KM398_25800	COG1950	PFAM Membrane protein of
KM398_25810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM398_25815	COG0556	nucleotide-excision repair
KM398_25835	COG0789	Transcriptional regulator
KM398_25860	COG2855	membrane
KM398_25865	COG0583	DNA-binding transcription factor activity
KM398_25875	COG0655	NAD(P)H dehydrogenase (quinone) activity
KM398_25880	COG0488	(ABC) transporter
KM398_25890	COG1132	(ABC) transporter
KM398_25895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM398_25900	COG0793	Belongs to the peptidase S41A family
KM398_25900	COG3409	Peptidoglycan-binding domain 1 protein
KM398_25905	COG2177	Part of the ABC transporter FtsEX involved in
KM398_25910	COG2884	Cell division ATP-binding protein ftsE
KM398_25925	COG0653	protein targeting
KM398_25930	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KM398_25935	COG1278	Cold shock
KM398_25940	COG1040	competence protein
KM398_25945	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KM398_25950	COG0791	NLP P60 protein
KM398_25950	COG1388	LysM domain
KM398_25955	COG1733	regulation of RNA biosynthetic process
KM398_25960	COG1307	EDD domain protein, DegV family
KM398_25965	COG1739	Uncharacterized protein family UPF0029
KM398_25970	COG1316	TRANSCRIPTIONal
KM398_25975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM398_25980	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KM398_25985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KM398_25995	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KM398_25995	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KM398_26010	COG3394	polysaccharide catabolic process
KM398_26015	COG1486	melibiose metabolic process
KM398_26020	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM398_26025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM398_26035	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KM398_26040	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM398_26045	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM398_26055	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM398_26060	COG1301	dicarboxylic acid transport
KM398_26070	COG0346	lactoylglutathione lyase activity
KM398_26075	COG1511	domain protein
KM398_26080	COG0583	DNA-binding transcription factor activity
KM398_26085	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KM398_26100	COG1271	oxidase subunit
KM398_26105	COG1294	oxidase, subunit
KM398_26110	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM398_26130	COG2389	metal-binding protein
KM398_26140	COG1368	sulfuric ester hydrolase activity
KM398_26155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM398_26165	COG1215	transferase activity, transferring glycosyl groups
KM398_26170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM398_26175	COG1388	LysM domain
KM398_26175	COG3584	3D domain protein
KM398_26200	COG4715	Zinc finger, swim domain protein
KM398_26205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM398_26245	COG0577	efflux transmembrane transporter activity
KM398_26250	COG1136	(ABC) transporter
KM398_26285	COG5002	protein histidine kinase activity
KM398_26290	COG0745	RESPONSE REGULATOR receiver
KM398_26295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM398_26310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM398_26315	COG1134	teichoic acid transport
KM398_26320	COG1682	transport, permease protein
KM398_26325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KM398_26370	COG1609	Transcriptional regulator
KM398_26385	COG0739	heme binding
KM398_26405	COG2385	sporulation resulting in formation of a cellular spore
KM398_26420	COG4836	Membrane
KM398_26425	COG1007	ATP synthesis coupled electron transport
KM398_26430	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM398_26435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM398_26445	COG0839	Belongs to the complex I subunit 6 family
KM398_26460	COG0649	NAD binding
KM398_26465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM398_26480	COG3300	MHYT domain
KM398_26480	COG5001	Diguanylate cyclase
KM398_26530	COG0356	it plays a direct role in the translocation of protons across the membrane
KM398_26565	COG0698	ribose 5-phosphate isomerase
KM398_26575	COG2190	(PTS) system
KM398_26580	COG2259	Doxx family
KM398_26585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KM398_26600	COG0009	L-threonylcarbamoyladenylate synthase
KM398_26615	COG2890	protein-(glutamine-N5) methyltransferase activity
KM398_26635	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KM398_26640	COG1494	fructose-1,6-bisphosphatase
KM398_26660	COG4821	SIS domain
KM398_26670	COG3343	RNA polymerase activity
KM398_26680	COG1960	acyl-CoA dehydrogenase activity
KM398_26685	COG1960	acyl-CoA dehydrogenase activity
KM398_26690	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM398_26695	COG0183	Belongs to the thiolase family
KM398_26700	COG2181	nitrate reductase activity
KM398_26700	COG0247	lactate metabolic process
KM398_26705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM398_26715	COG5001	Diguanylate cyclase
KM398_26715	COG3300	MHYT domain
KM398_26735	COG2197	response regulator
KM398_26740	COG4585	Histidine kinase
KM398_26745	COG0842	Transport permease protein
KM398_26750	COG1131	(ABC) transporter
KM398_26755	COG0024	Methionine aminopeptidase
KM398_26765	COG2234	aminopeptidase activity
KM398_26785	COG1595	DNA-templated transcription, initiation
KM398_26790	COG0018	arginyl-trna synthetase
KM398_26795	COG4506	Protein conserved in bacteria
KM398_26800	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM398_26815	COG0010	Belongs to the arginase family
KM398_26825	COG2814	Major facilitator Superfamily
KM398_26830	COG0789	Transcriptional regulator
KM398_26835	COG0584	glycerophosphoryl diester phosphodiesterase
KM398_26840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM398_26850	COG1994	Peptidase M50
KM398_26860	COG1078	dGTPase activity
KM398_26865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM398_26870	COG1120	ATPase activity
KM398_26875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM398_26900	COG0095	Lipoate-protein ligase
KM398_26905	COG0280	phosphate acetyltransferase
KM398_26920	COG3773	Cell wall hydrolase
KM398_26930	COG2363	Small membrane protein
KM398_26940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM398_26945	COG2233	PERMEase
KM398_26950	COG0561	phosphatase activity
KM398_26955	COG2814	Major facilitator Superfamily
KM398_26965	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM398_26970	COG1131	(ABC) transporter
KM398_26975	COG2755	lipolytic protein G-D-S-L family
KM398_26980	COG1609	Transcriptional regulator
KM398_26990	COG0460	homoserine dehydrogenase
KM398_27000	COG2873	o-acetylhomoserine
KM398_27010	COG1011	Hydrolase
KM398_27015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM398_27025	COG2197	response regulator
KM398_27035	COG0351	phosphomethylpyrimidine kinase
KM398_27040	COG3706	GGDEF domain
KM398_27045	COG2879	small protein
KM398_27050	COG1966	Carbon starvation protein
KM398_27055	COG3279	Response regulator of the LytR AlgR family
KM398_27060	COG0477	Major facilitator Superfamily
KM398_27085	COG0840	transmembrane signaling receptor activity
KM398_27095	COG1607	acyl-coa hydrolase
KM398_27110	COG0488	(ABC) transporter
KM398_27130	COG0463	Glycosyl transferase, family 2
KM398_27135	COG1309	transcriptional regulator
KM398_27140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM398_27145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM398_27145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM398_27150	COG0628	permease
KM398_27165	COG3279	Response regulator of the LytR AlgR family
KM398_27170	COG3275	phosphorelay sensor kinase activity
KM398_27175	COG2814	Major facilitator Superfamily
KM398_27180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM398_27185	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KM398_27190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM398_27210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM398_27215	COG1272	protein, Hemolysin III
KM398_27235	COG0516	GMP reductase activity
KM398_27240	COG1164	Oligoendopeptidase f
KM398_27260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM398_27265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KM398_27270	COG4853	Protein conserved in bacteria
KM398_27275	COG4863	YycH protein
KM398_27280	COG5002	protein histidine kinase activity
KM398_27285	COG0745	RESPONSE REGULATOR receiver
KM398_27315	COG0305	Participates in initiation and elongation during chromosome replication
KM398_27325	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KM398_27330	COG4241	membrane
KM398_27340	COG0629	single-stranded DNA binding
KM398_27350	COG0012	GTP binding
KM398_27355	COG4481	Protein conserved in bacteria
KM398_27360	COG0668	transmembrane transport
KM398_27370	COG1475	DNA binding
KM398_27375	COG1192	Involved in chromosome partitioning
KM398_27400	COG1847	R3H domain protein
KM398_27405	COG0706	membrane insertase activity
KM398_27415	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KM398_27465	COG3344	reverse transcriptase
KM398_27545	COG3344	reverse transcriptase
KM398_27735	COG4962	Type ii secretion system protein e
KM398_27870	COG2311	Membrane
KM398_27895	COG4196	transglutaminase domain protein
KM398_27900	COG0671	phosphoesterase, PA-phosphatase related
KM398_27915	COG1215	transferase activity, transferring glycosyl groups
KM398_27920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM398_27925	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KM398_28095	COG2002	toxin-antitoxin pair type II binding
KM398_28105	COG4974	Belongs to the 'phage' integrase family
KM398_28160	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM398_28170	COG4974	Belongs to the 'phage' integrase family
KM398_28195	COG0457	Tetratricopeptide repeat
KM398_28400	COG0791	NLP P60 protein
KM398_28400	COG0741	lytic transglycosylase activity
KM398_28465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM398_28525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM398_28535	COG4166	transmembrane transport
KM398_28575	COG1280	lysine exporter protein (LysE YggA)
KM398_28600	COG0681	Belongs to the peptidase S26 family
KM398_28675	COG1309	transcriptional regulator
KM398_28680	COG1683	Conserved Protein
KM398_28720	COG1192	Involved in chromosome partitioning