locus-tag class description BF90_10 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF90_1002 ENOG4105F7F Chaperone BF90_1004 ENOG4105CHR reductase BF90_1005 ENOG4108YXU transcriptional regulator AsnC family BF90_101 ENOG4108MES Periplasmic binding protein BF90_1019 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BF90_102 ENOG4105F0I Aminotransferase BF90_1020 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF90_1022 ENOG4105IIP Membrane BF90_1025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF90_1026 ENOG41062D9 Histidine kinase BF90_1031 ENOG4105K6H D-cysteine desulfhydrase BF90_1037 ENOG4105VZ8 Transcriptional regulator BF90_1040 ENOG4108NNI Beta-lactamase domain-containing protein BF90_1041 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BF90_1043 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF90_1044 ENOG4105JQZ Methyltransferase BF90_1047 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF90_1048 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BF90_1051 ENOG4105BZU Histidine kinase BF90_1054 ENOG4108U05 Transcriptional regulator BF90_1055 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BF90_1057 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF90_1058 ENOG4105DJB Major Facilitator Superfamily BF90_1059 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BF90_1060 ENOG4107QR9 Iron-sulfur cluster binding protein BF90_1062 ENOG4106P55 Transcriptional regulator BF90_1064 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF90_1070 ENOG4105TRI Hydrolase BF90_1078 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF90_1085 ENOG4107QJQ Mate efflux family protein BF90_1088 ENOG4105MZU cell filamentation protein BF90_1089 ENOG4105EQ0 Major Facilitator superfamily BF90_109 ENOG4105D8X mechanosensitive ion channel BF90_1090 ENOG4108JGH Tetr family transcriptional regulator BF90_1093 ENOG4105C44 Serine transporter BF90_1094 ENOG4105EJQ L-serine dehydratase BF90_1097 ENOG4108JPW Aminotransferase BF90_110 ENOG4105BZU Histidine kinase BF90_1103 ENOG4105DVH amino acid BF90_1106 ENOG4108JQ1 Dehydrogenase BF90_111 ENOG4105WH1 Two component transcriptional regulator luxr family BF90_1110 ENOG4108AEY RNA polymerase sigma factor BF90_1113 ENOG41082W1 Cupin 2, conserved barrel domain protein BF90_1114 ENOG410874W AraC family transcriptional regulator BF90_1117 ENOG4105HIR S-layer domain protein BF90_1125 ENOG4108ISG Major Facilitator BF90_1127 ENOG4107MII Sugar-specific transcriptional regulator TrmB BF90_1128 ENOG4105CZM Major Facilitator BF90_113 ENOG4106KNT transcriptional regulator BF90_1132 ENOG4105DA5 (ABC) transporter BF90_1133 ENOG41069JR BF90_1135 ENOG4105RXJ BF90_1136 ENOG4105KPY Small multidrug resistance protein BF90_1137 ENOG4105KBX Transcriptional regulator, TetR family BF90_1139 ENOG4105CRW Short chain fatty acid transporter BF90_1141 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF90_1148 ENOG4108JJB ABC transporter BF90_1149 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF90_1155 ENOG4108K8S endonuclease I BF90_1158 ENOG41067QW Transcriptional regulator BF90_1160 ENOG4108Z66 YbaK ebsC protein BF90_1161 ENOG4105CUT histidyl-tRNA synthetase BF90_1164 ENOG4105KVH Transcriptional regulator BF90_1165 ENOG4108RCM Nitroreductase BF90_1169 ENOG4108PSK reductase BF90_1171 ENOG4105CJ1 ABC, transporter BF90_1183 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BF90_1184 ENOG4105DKQ ROK family BF90_1185 ENOG4106UW1 Major Facilitator superfamily BF90_1186 ENOG4108UW5 maltose o-acetyltransferase BF90_1188 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF90_1190 ENOG4105C31 Tryptophanyl-tRNA synthetase BF90_1191 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF90_1196 ENOG4105DMQ Methyltransferase BF90_1198 ENOG4105EV4 Multidrug resistance protein mdtH BF90_120 ENOG4105CMG Carbohydrate kinase BF90_1204 ENOG4105C37 (CBS) domain BF90_1207 ENOG4105DDN Pentapeptide repeat-containing protein BF90_1208 ENOG4105XDF Protein of unknown function (DUF1272) BF90_1209 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BF90_121 ENOG4105CMG Carbohydrate kinase BF90_1210 ENOG4105CMG Carbohydrate kinase BF90_1211 ENOG4105C6Z Gluconate BF90_1212 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF90_1215 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF90_1216 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF90_1217 ENOG4105CIS alcohol dehydrogenase BF90_1218 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BF90_1221 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BF90_1222 ENOG4105D4Y metalloprotease BF90_1226 ENOG4105CV8 reductase BF90_1227 ENOG4105F27 Major Facilitator BF90_1230 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BF90_1231 ENOG4105C44 Serine transporter BF90_1237 ENOG4105KVH Transcriptional regulator BF90_1238 ENOG4108TZY GntR Family Transcriptional Regulator BF90_1239 ENOG4105D9R oxidoreductase BF90_1240 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BF90_1241 ENOG4105KVH Transcriptional regulator BF90_1242 ENOG4105KVH Transcriptional regulator BF90_1249 ENOG4105JAB phenazine biosynthesis protein, phzf family BF90_1251 ENOG4105CHR reductase BF90_1255 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BF90_1256 ENOG4105KVH Transcriptional regulator BF90_1260 ENOG4108ZJ4 polysaccharide deacetylase BF90_127 ENOG4108IJ8 ABC transporter BF90_1270 ENOG4105KAF membrAne BF90_1275 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BF90_1279 ENOG4107YXZ hydrolase, family 25 BF90_128 ENOG4105E90 ABC transporter BF90_1284 ENOG4105ED2 Beta-lactamase BF90_1286 ENOG4105H3G oxidoreductase BF90_1294 ENOG4105CIS alcohol dehydrogenase BF90_1301 ENOG4108TN2 lmbE family BF90_1303 ENOG4107R3E Citrate transporter BF90_1307 ENOG4108MES Periplasmic binding protein BF90_1309 ENOG4105EHG Permease protein BF90_1310 ENOG4105DQ5 transport system permease protein BF90_1311 ENOG4105NX3 Membrane BF90_1312 ENOG4107ZY0 Phenazine biosynthesis-like protein BF90_1316 ENOG4107CUJ Protein of unknown function (DUF2690) BF90_1318 ENOG4107V2S Transcriptional regulator BF90_1322 ENOG4105C98 muts2 protein BF90_1324 ENOG4105E5K Alpha-amylase BF90_1326 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BF90_1327 ENOG4105DPN Oligoendopeptidase f BF90_1328 ENOG4108A04 Beta-lactamase BF90_1335 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF90_1339 ENOG41082BM Transcriptional regulator, arsr family BF90_1340 ENOG4105CIS alcohol dehydrogenase BF90_1347 ENOG4105RHY Pfam:UPF0157 BF90_1349 ENOG4105C09 Bile acid BF90_135 ENOG4105C37 (CBS) domain BF90_1350 ENOG4105CQB FAD linked oxidase domain protein BF90_1354 ENOG4108UT6 Transferase hexapeptide repeat containing protein BF90_1356 ENOG4105K64 Glycosyl transferase, family 2 BF90_1357 ENOG4105E39 Enoyl-CoA hydratase BF90_1359 ENOG4105KT7 mgtC SapB transporter BF90_1361 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF90_1362 ENOG41073R8 VanW family BF90_1364 ENOG4108R1P BF90_1368 ENOG4105VEQ Cold shock protein BF90_1372 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BF90_1376 ENOG410904N short-chain dehydrogenase reductase BF90_1378 ENOG4106IQC argininosuccinate lyase BF90_1382 ENOG4108IA2 Sodium pantothenate symporter BF90_1384 ENOG4105C26 Dehydrogenase BF90_1385 ENOG4105CHR reductase BF90_1387 ENOG4105EWU Squalene--hopene cyclase BF90_1389 ENOG4105FR1 rard protein BF90_1390 ENOG410696E Membrane BF90_1393 ENOG4105D1F ATP-binding protein BF90_1395 ENOG4108ZAF Molybdopterin BF90_1396 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF90_1397 ENOG4105D06 uba thif-type nad fad binding protein BF90_1398 ENOG4105TMB Formate nitrite transporter BF90_14 ENOG4105C5H ABC transporter BF90_140 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF90_1400 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF90_1401 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BF90_1403 ENOG4108JB9 formate dehydrogenase BF90_1405 ENOG4105E1K spore germination protein BF90_1417 ENOG4107QJT sodium dicarboxylate symporter BF90_1418 ENOG4108KGH TRANSCRIPTIONal BF90_1420 ENOG4105EMN RNA polymerase sigma factor BF90_1424 ENOG4105CIG ABC transporter BF90_1426 ENOG4105D9R oxidoreductase BF90_1428 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF90_1429 ENOG4105K4P CoA-binding domain protein BF90_143 ENOG4107S4Y M20 DapE family protein YgeY BF90_1430 ENOG4105C0H protease BF90_1431 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF90_1433 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BF90_1434 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF90_1435 ENOG4105W8X HesB YadR YfhF-family protein BF90_144 ENOG4108TSC N-acetyltransferase BF90_1441 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF90_1442 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF90_1444 ENOG4108JJA ABC, transporter BF90_1445 ENOG4108I0Z Aconitate hydratase BF90_145 ENOG4108JUB Transcriptional regulator BF90_1450 ENOG4105E5W Transporter BF90_1452 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF90_1456 ENOG4107F3J Amp-dependent synthetase and ligase BF90_1457 ENOG4107ZYJ bioY protein BF90_1458 ENOG4105CEY Amp-dependent synthetase and ligase BF90_146 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BF90_1467 ENOG4107AYK membrAne BF90_1469 ENOG4105BZU Histidine kinase BF90_1470 ENOG4105FBA Phospholipase Carboxylesterase BF90_1471 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BF90_1472 ENOG4105CK7 Sodium proline symporter BF90_1473 ENOG4105CBC glutamate synthase BF90_1474 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF90_1475 ENOG4108VJ1 Transcriptional regulator (CarD family BF90_1476 ENOG4108903 Formimidoylglutamase BF90_1481 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BF90_1492 ENOG4107QIV Cytochrome c biogenesis protein BF90_1494 ENOG4107RSM transcriptional regulator BF90_1495 ENOG4105VAW lrga family BF90_1496 ENOG41067MG lrgb family BF90_1502 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF90_1505 ENOG4105BZ1 (ABC) transporter BF90_1506 ENOG4105BZ1 (ABC) transporter BF90_1510 ENOG4105D7V transposase BF90_1513 ENOG4105D5T phosphonate abc transporter BF90_1516 ENOG4105CGH 5'-nucleotidase BF90_1518 ENOG4108SVB resolvase BF90_1522 ENOG4105K7K Transcriptional regulator BF90_1530 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BF90_1531 ENOG4105XSJ toxin secretion phage lysis holin BF90_154 ENOG4108N23 SpoOM-related protein BF90_156 ENOG410841Q phosphoesterase PA-phosphatase related protein BF90_157 ENOG4105SZ6 Thioredoxin BF90_1571 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BF90_159 ENOG4108IBT Inherit from COG: transposase BF90_1592 ENOG4105C5F glutamine synthetase BF90_1593 ENOG4105KV4 Transcriptional regulator BF90_1594 ENOG4105CXI aluminum resistance protein BF90_1595 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF90_1596 ENOG4105EN6 Membrane BF90_1598 ENOG4106F1P AAA ATPase, central domain protein BF90_1604 ENOG41069ER domain protein BF90_1605 ENOG4105DM4 PTS System BF90_1606 ENOG4105DE4 1-phosphofructokinase BF90_1607 ENOG4105E98 transcriptional regulator DeoR family BF90_1608 ENOG4107QW4 alcohol dehydrogenase BF90_1609 ENOG4107QW4 alcohol dehydrogenase BF90_1610 ENOG4108SJC Membrane BF90_1613 ENOG4105C85 amino acid BF90_1618 ENOG4105TMB Formate nitrite transporter BF90_1619 ENOG4105K70 DNA-binding protein BF90_1620 ENOG4105C59 p-type ATPase BF90_1621 ENOG410681U heavy metal transport detoxification protein BF90_1622 ENOG4105VPX protein, conserved in bacteria BF90_1624 ENOG4105NIV Esterase BF90_1625 ENOG4105E0A ABC, transporter BF90_1630 ENOG4105CGK Exodeoxyribonuclease III BF90_1631 ENOG4105CGK Exodeoxyribonuclease III BF90_1633 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF90_1634 ENOG4105D03 DNA-3-methyladenine glycosylase II BF90_1641 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BF90_1643 ENOG4105BZU Histidine kinase BF90_1646 ENOG41067MG lrgb family BF90_1649 ENOG4107TTQ Alpha beta hydrolase fold BF90_1650 ENOG4107YEI lmbE family BF90_1654 ENOG4105F0V Cell wall hydrolase BF90_1655 ENOG4107R6R udp-galactopyranose mutase BF90_1656 ENOG4105E0M Sulfatase BF90_1657 ENOG410890F Dynamin family BF90_1659 ENOG4107QHE Choloylglycine hydrolase BF90_1664 ENOG4105DA5 (ABC) transporter BF90_1669 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF90_1670 ENOG4105DQU oxidoreductase, subunit beta BF90_1671 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BF90_1672 ENOG4108IGT Dipeptidase BF90_1673 ENOG4105MCT stage V sporulation protein S BF90_1674 ENOG4105D48 metallophosphoesterase BF90_1679 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BF90_1682 ENOG4105XZV Protein of unknown function (DUF3243) BF90_1683 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BF90_1687 ENOG4105UIB (ABC) transporter BF90_1688 ENOG4105UIB (ABC) transporter BF90_1689 ENOG4108JQ9 ABC transporter BF90_1690 ENOG4105DIH basic membrane BF90_1691 ENOG4105FDP GntR family transcriptional regulator BF90_1692 ENOG4107QZI cell division protein FtsK BF90_1694 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BF90_1696 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF90_1698 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF90_1699 ENOG4108S0H Dipicolinic acid synthetase, b subunit BF90_17 ENOG4108UUM single-stranded DNA-binding protein BF90_1700 ENOG4105E35 Dipicolinate synthase subunit A BF90_1702 ENOG4105C1V Peptidase, M16 BF90_1706 ENOG4105DTN riboflavin biosynthesis protein ribF BF90_1707 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BF90_1709 ENOG4105W7A Protein of unknown function (DUF503) BF90_1711 ENOG4105VHM ribosomal protein BF90_1712 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BF90_1713 ENOG4105CHV Transcription elongation factor NusA BF90_1715 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF90_1717 ENOG4105DZP Membrane-associated zinc metalloprotease BF90_1718 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF90_1719 ENOG4105KNE Phosphatidate cytidylyltransferase BF90_1728 ENOG4108HE4 integrase family BF90_1730 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF90_1732 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BF90_1735 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BF90_1740 ENOG4105VB6 UPF0109 protein BF90_1744 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BF90_1745 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BF90_1748 ENOG4105CHR reductase BF90_1749 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BF90_1752 ENOG4105CB5 ATP-dependent DNA helicase recG BF90_1753 ENOG4105DP4 dak2 domain fusion protein ylov BF90_1754 ENOG4108ZAA Alkaline-shock protein BF90_1756 ENOG4105FJ0 thiamine BF90_1757 ENOG4105DJV ribulose-phosphate 3-epimerase BF90_1758 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BF90_1759 ENOG4105D9P serine threonine protein kinase BF90_1760 ENOG4108ZF3 Phosphatase BF90_1762 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF90_1764 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF90_1765 ENOG4105C25 Primosomal protein n' BF90_1766 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BF90_1770 ENOG4105DSJ YicC domain protein BF90_1772 ENOG4105F23 Fibronectin-binding protein BF90_1773 ENOG4105DC7 peptidase M24 BF90_178 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF90_1784 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BF90_1789 ENOG4105C34 Pseudouridine synthase BF90_1792 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF90_1794 ENOG4105DBK s4 domain protein BF90_1795 ENOG41067XK integral membrane protein BF90_1797 ENOG4105DFA alanine racemase domain protein BF90_1798 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BF90_1799 ENOG4105WR5 sporulation protein, YlmC YmxH family BF90_1801 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF90_1803 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BF90_1804 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BF90_1805 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BF90_1806 ENOG4105D4A Cell wall formation (By similarity) BF90_1807 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF90_1808 ENOG4105CNI cell division protein FtsW BF90_1811 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF90_1812 ENOG4105CJN penicillin-binding protein BF90_1813 ENOG4105CJN penicillin-binding protein BF90_1814 ENOG41068DC Essential cell division protein (By similarity) BF90_1821 ENOG4105KNH Nucleic acid-binding protein BF90_1831 ENOG4105XSJ toxin secretion phage lysis holin BF90_1849 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF90_1851 ENOG4105CAR Terminase, large subunit BF90_186 ENOG4105BZ4 penicillin-binding protein BF90_1868 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BF90_187 ENOG4105CZM Major Facilitator BF90_1871 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF90_188 ENOG4105W8X HesB YadR YfhF-family protein BF90_1881 ENOG4108IMY Transcriptional regulator BF90_1889 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BF90_1891 ENOG41063PX domain protein BF90_1892 ENOG4105D78 K07001 NTE family protein BF90_1894 ENOG4105H20 Sporulation integral membrane protein YlbJ BF90_1895 ENOG4106H78 methyltransferase BF90_190 ENOG4105DXD 2-methylcitrate dehydratase BF90_1900 ENOG4107TB6 phosphoglycerate mutase BF90_1903 ENOG4106UY4 Inherit from COG: Scp-like extracellular BF90_191 ENOG4105CR4 methylisocitrate lyase BF90_1913 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BF90_1914 ENOG4105CNI cell division protein FtsW BF90_1917 ENOG4108IAB Phoh family BF90_192 ENOG4105C1G acyl-Coa dehydrogenase BF90_1921 ENOG4105QA2 BF90_1922 ENOG4105CI3 gtp-binding protein typa BF90_1924 ENOG4105ECY inositol monophosphatase BF90_1928 ENOG4105CXN decarboxylase BF90_193 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF90_1938 ENOG4105CPP Dehydrogenase, E1 component BF90_1941 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF90_1942 ENOG4108X4Q Hydrolase BF90_1944 ENOG4105CN5 Metallo-Beta-Lactamase BF90_1945 ENOG4107ZYR domain protein BF90_195 ENOG4105N14 lysine exporter protein LysE YggA BF90_1952 ENOG4108XRC Protein of unknown function (DUF458) BF90_1954 ENOG4107IN1 Protein of unknown function (DUF1797) BF90_1957 ENOG4105EPM Diguanylate phosphodiesterase BF90_1958 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BF90_196 ENOG4105E39 Enoyl-CoA hydratase BF90_1961 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF90_1962 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF90_1964 ENOG4105UIN BF90_1975 ENOG4108HGU Histidine kinase BF90_1977 ENOG4105CHM Aminotransferase BF90_1978 ENOG4105FKQ transcriptional regulator BF90_1979 ENOG4105EG2 ABC transporter, permease BF90_1981 ENOG4107FKK extracellular solute-binding protein family 1 BF90_1983 ENOG4105CG3 alpha amylase, catalytic region BF90_199 ENOG4107RFY SbcCD D subunit BF90_1992 ENOG4105CHU acetyl-coa acetyltransferase BF90_1999 ENOG4105K7K Transcriptional regulator BF90_20 ENOG41061H0 Monooxygenase BF90_200 ENOG4105EYH Exonuclease BF90_2000 ENOG4105DTD Dehydrogenase BF90_2002 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BF90_2004 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BF90_2009 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BF90_2012 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF90_2013 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF90_2014 ENOG4106TD9 Diguanylate cyclase BF90_2018 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BF90_2021 ENOG4105CID antiterminator BF90_2023 ENOG4105FDP GntR family transcriptional regulator BF90_2025 ENOG4105CE4 GlcNAc 6-P deacetylase BF90_2032 ENOG4107ZE5 PPIases accelerate the folding of proteins BF90_2033 ENOG4105PTM secreted protein BF90_2034 ENOG4105J7I hydrolase BF90_2036 ENOG4105G6R Stage v sporulation protein ae BF90_2038 ENOG4105CZ3 stage V sporulation protein ad BF90_2039 ENOG41090VF Stage v sporulation protein ac BF90_204 ENOG4105FCD Major Facilitator BF90_2043 ENOG4105C8J )-transporter BF90_2044 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF90_2046 ENOG41082AN stage II sporulation protein BF90_2047 ENOG4105DZ1 carboxypeptidase BF90_2048 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF90_2049 ENOG4105DVE abc transporter atp-binding protein BF90_205 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BF90_2055 ENOG4105D7N magnesium and cobalt transport protein CorA BF90_206 ENOG4105E4F Isochorismate synthase BF90_2060 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF90_2062 ENOG4105I3K Ferric uptake regulator, Fur family BF90_2063 ENOG4105MZ9 stage II sporulation protein m BF90_2067 ENOG4105CPC Aldo Keto reductase BF90_2069 ENOG4105RHY Pfam:UPF0157 BF90_207 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BF90_2073 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF90_2075 ENOG4105ETE Transcriptional regulator (LacI family BF90_2076 ENOG4108YM7 Gcn5-related n-acetyltransferase BF90_208 ENOG4105WQI isochorismatase BF90_2080 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BF90_2081 ENOG4108R6K riboflavin synthase, subunit alpha BF90_2085 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BF90_2086 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF90_2087 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF90_2088 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BF90_209 ENOG4105CEY Amp-dependent synthetase and ligase BF90_2090 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF90_2092 ENOG4105DFD Na H antiporter BF90_2093 ENOG4105CGH 5'-nucleotidase BF90_210 ENOG4105CEY Amp-dependent synthetase and ligase BF90_2101 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BF90_2104 ENOG4108IXY short-chain dehydrogenase reductase BF90_2105 ENOG41069FQ Metallo-beta-lactamase superfamily BF90_2106 ENOG4105II7 pyrroline-5-carboxylate reductase BF90_2107 ENOG4105EJQ L-serine dehydratase BF90_211 ENOG4105WQT MbtH domain protein BF90_2111 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF90_2113 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF90_2114 ENOG4105D9U N-acetyltransferase BF90_2116 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BF90_2117 ENOG4108QEG Membrane BF90_2118 ENOG4105CDA abc transporter atp-binding protein BF90_2119 ENOG4105E5Q amino acid AbC transporter BF90_212 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF90_2120 ENOG4108HW3 (ABC) transporter BF90_2122 ENOG4105G7B Protein of unknown function (DUF2992) BF90_2123 ENOG4105E09 nadh pyrophosphatase BF90_2125 ENOG4105C7S Dehydrogenase BF90_2126 ENOG4105CPP Dehydrogenase, E1 component BF90_2130 ENOG4107RDP Dehydrogenase BF90_2132 ENOG4108JUB Transcriptional regulator BF90_2134 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF90_2137 ENOG4107QQR Sporulation BF90_2138 ENOG4105S1Z Stage IV sporulation protein B BF90_2139 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BF90_2141 ENOG4105DX0 Hemolysin A BF90_2143 ENOG4105CTB Polyprenyl synthetase BF90_2148 ENOG4108ZSR alkaline shock protein BF90_2149 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF90_215 ENOG4105K70 DNA-binding protein BF90_2154 ENOG410644B Stage III sporulation protein af BF90_2156 ENOG4105KQ4 Stage iii sporulation protein ad BF90_2157 ENOG4108CQH stage III sporulation protein AC BF90_2158 ENOG4105KR5 Stage iii sporulation protein BF90_2159 ENOG4105CD2 stage iii sporulation protein aa BF90_2164 ENOG4105DC7 peptidase M24 BF90_2167 ENOG4105CBJ Metal-dependent enzyme BF90_2168 ENOG4107YBY Hydrolase BF90_2173 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BF90_2174 ENOG4105WZW rhodanese family BF90_2178 ENOG41080TC multidrug resistance protein BF90_2185 ENOG4105CJ1 ABC, transporter BF90_2186 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF90_219 ENOG4105BZG amino acid carrier protein BF90_2192 ENOG4105C0D helicase BF90_220 ENOG4105BZG amino acid carrier protein BF90_2216 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF90_2217 ENOG4105C3R Methionine synthase BF90_2220 ENOG4105C28 cystathionine BF90_2221 ENOG4105C28 cystathionine BF90_2225 ENOG4105C5X domain protein BF90_2227 ENOG4105DKQ ROK family BF90_2229 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BF90_2232 ENOG4108UTW Plays a role in the regulation of phosphate uptake BF90_2233 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BF90_2234 ENOG4105E2Z phosphate ABC transporter (Permease BF90_2235 ENOG4105C8U phosphate abc transporter BF90_2236 ENOG4105PWN phosphate abc transporter BF90_2237 ENOG4107RF6 penicillin-binding protein BF90_2239 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF90_224 ENOG4105FE9 pseudouridine synthase BF90_2244 ENOG4105N80 Ferric uptake regulator, Fur family BF90_2246 ENOG4105FDK ABC transporter BF90_2247 ENOG4108JYZ YitT family BF90_2248 ENOG41069ZM Protein of unknown function (DUF2624) BF90_225 ENOG4105C22 threonyL-tRNA synthetase BF90_2253 ENOG4105EGD dinuclear metal center protein, YbgI family BF90_2256 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF90_2257 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BF90_226 ENOG4105C19 ABC transporter BF90_2262 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BF90_2263 ENOG4105KG3 cytidine deaminase BF90_2264 ENOG4107YR5 Diacylglycerol kinase BF90_2266 ENOG4105CTJ Metal Dependent Phosphohydrolase BF90_2267 ENOG4105C9A Phoh family BF90_2269 ENOG41068P3 sporulation protein YqfC BF90_2270 ENOG4105KTH gatB Yqey BF90_2272 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF90_2273 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BF90_2277 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BF90_2279 ENOG4105CSA Coproporphyrinogen iii oxidase BF90_2280 ENOG4105KVH Transcriptional regulator BF90_2285 ENOG4105TQK DNA polymerase iii, delta' subunit BF90_2287 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF90_2288 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF90_2289 ENOG4108UK2 deaminase BF90_229 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF90_2290 ENOG4105KQC Competence protein BF90_2292 ENOG4105DXX methyltransferase BF90_2294 ENOG4108WF2 Metal Dependent Phosphohydrolase BF90_2296 ENOG410812S Rna-binding protein BF90_2298 ENOG4105CQW ribosome biogenesis GTPase YqeH BF90_2299 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF90_2302 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF90_2306 ENOG4108TVJ Nitroreductase BF90_2309 ENOG4105G6Z alkaline phosphatase BF90_2311 ENOG4108MUZ hydrolase BF90_2318 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF90_2319 ENOG4105MIR Phenylalanine 4-monooxygenase BF90_2321 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF90_2329 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF90_2330 ENOG4108V5C ABC transporter BF90_2332 ENOG4108EKI Dehydrogenase BF90_2333 ENOG4105C28 cystathionine BF90_2339 ENOG4107XRG penicillin-binding protein BF90_2342 ENOG4105CFP Peptidase U32 BF90_2343 ENOG4105XYU peptidase (U32 family) BF90_2344 ENOG4108VQJ O-methyltransferase BF90_2345 ENOG4105HHA aminodeoxychorismate lyase BF90_2349 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF90_235 ENOG4108D32 Methyltransferase BF90_2351 ENOG4105C02 permease BF90_2354 ENOG41060CR BF90_2355 ENOG4105C7H Helicase, RecD TraA family BF90_2357 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BF90_2358 ENOG4105C3J Cysteine desulfurase BF90_2360 ENOG4105D1H recombination factor protein RarA BF90_2361 ENOG4108VCI transcription factor, rsfa family BF90_2362 ENOG4105CUZ uba thif-type nad fad binding protein BF90_2364 ENOG4105CUT histidyl-tRNA synthetase BF90_2367 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF90_2369 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF90_2370 ENOG41076HS cation diffusion facilitator family transporter BF90_2371 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BF90_2373 ENOG4105CKP Polysaccharide Biosynthesis Protein BF90_2374 ENOG4108QG2 Membrane BF90_2376 ENOG4105VIE preprotein translocase, subunit YajC BF90_2379 ENOG41061AI Protein of unknown function (DUF2905) BF90_2382 ENOG4108HUF Transporter BF90_2384 ENOG4108IPJ Membrane BF90_2385 ENOG4108IPJ Membrane BF90_2386 ENOG41082BM Transcriptional regulator, arsr family BF90_2391 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BF90_2392 ENOG4108IYU L-aspartate oxidase BF90_2395 ENOG4108RPX mosc domain containing protein BF90_2396 ENOG4105CQC Prephenate dehydratase BF90_24 ENOG4107YX5 Pfam:DUF548 BF90_2400 ENOG4105EWM Histidine kinase BF90_2403 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BF90_2406 ENOG4105X36 (ribosomal) protein BF90_2408 ENOG4105C03 ribonuclease BF90_241 ENOG41081I9 integral membrane protein BF90_2411 ENOG4107QMS site-determining protein BF90_2414 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BF90_2415 ENOG4105DFF Rod shape-determining protein mreb BF90_2419 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BF90_2420 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BF90_2422 ENOG41068KH stage VI sporulation protein D BF90_2424 ENOG4105D52 delta-aminolevulinic acid dehydratase BF90_2429 ENOG4105K56 Transcriptional regulator BF90_2433 ENOG4108IUQ atp-dependent protease BF90_2439 ENOG4108QCI YvbH-like oligomerisation region BF90_244 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF90_2443 ENOG4105M59 Phosphodiesterase, mj0936 family BF90_2444 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BF90_2446 ENOG4108XJQ germination protein BF90_2448 ENOG4108PCX Major Facilitator BF90_2450 ENOG4105KBX Transcriptional regulator, TetR family BF90_2453 ENOG4105PFC Transcriptional regulator BF90_2456 ENOG4105DZC cytosine deaminase BF90_2457 ENOG4105DZC cytosine deaminase BF90_2458 ENOG4105DEF Extracellular solute-binding protein, family 5 BF90_2459 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF90_246 ENOG4105EYF MMPL domain protein BF90_2462 ENOG4108JQ7 (ABC) transporter BF90_2463 ENOG4108HRK Histidine kinase BF90_2464 ENOG4105DY9 regulatoR BF90_2467 ENOG41067S9 phage shock protein C, PspC BF90_2468 ENOG4108JCI Transcriptional regulator BF90_2470 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BF90_2471 ENOG4108Z40 Transcriptional regulator BF90_2472 ENOG4105RHA ABC transporter, permease BF90_2473 ENOG4108IUX (ABC) transporter BF90_2474 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BF90_2475 ENOG4105ER2 Ompa motb domain protein BF90_2476 ENOG4105ER2 Ompa motb domain protein BF90_2477 ENOG4105E14 MotA TolQ exbB proton channel BF90_2478 ENOG4108VXD carboxy-peptidase BF90_2480 ENOG4105E33 succinate dehydrogenase BF90_2482 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BF90_2485 ENOG4105K63 Thioredoxin BF90_2486 ENOG4105C10 Electron transfer flavoprotein BF90_2487 ENOG4105BZJ Electron transfer flavoprotein BF90_2488 ENOG41060WC Enoyl-CoA hydratase BF90_2489 ENOG4107Z3H Transcriptional regulator, TetR family BF90_2490 ENOG4105CEY Amp-dependent synthetase and ligase BF90_2492 ENOG4105J76 Periplasmic binding protein BF90_2493 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF90_25 ENOG4105C75 arginyL-tRNA synthetase BF90_2502 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF90_2505 ENOG4105DR4 Methyltransferase BF90_2508 ENOG4105KFN sortase, SrtB family BF90_2509 ENOG4105E0A ABC, transporter BF90_251 ENOG4105WCN acetyltransferase BF90_2512 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BF90_2513 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BF90_2515 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BF90_2517 ENOG4105FE9 pseudouridine synthase BF90_2520 ENOG4105DCG PHP domain protein BF90_2527 ENOG4105C5S asparaginyl-tRNA synthetase BF90_2528 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BF90_2530 ENOG4108RWN rrna methyltransferase BF90_2537 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF90_2538 ENOG4105CW7 secretion protein, HlyD family BF90_2539 ENOG4108JGH Tetr family transcriptional regulator BF90_2540 ENOG4105CN9 Peptidase m42 family protein BF90_2544 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BF90_2545 ENOG4105C22 threonyL-tRNA synthetase BF90_2546 ENOG4108TDW sporulation protein YtxC BF90_2550 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF90_2551 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BF90_2552 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BF90_2554 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BF90_2555 ENOG4105C2M dna polymerase I BF90_2556 ENOG4105BZU Histidine kinase BF90_2557 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF90_2561 ENOG4108HMX isocitrate dehydrogenase (NADP) BF90_2562 ENOG4105BZN citrate synthase BF90_2564 ENOG4108REF Sporulation integral membrane protein ytvi BF90_2565 ENOG4105FS0 cytoplasmic membrane protein BF90_257 ENOG4105C1Q protoporphyrinogen oxidase BF90_2570 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF90_2571 ENOG4105C6K Malic enzyme BF90_2572 ENOG4105C0B DNA polymerase III (alpha subunit) BF90_2573 ENOG4105VV2 BF90_2575 ENOG4105SFS phosphoesterase RecJ domain protein BF90_2582 ENOG4105DC7 peptidase M24 BF90_2589 ENOG4105Z7P Acetyltransferase (GNAT) family BF90_259 ENOG41068WN BF90_2590 ENOG41082W1 Cupin 2, conserved barrel domain protein BF90_2592 ENOG4105VZ8 Transcriptional regulator BF90_2596 ENOG4107YZX Universal stress protein BF90_2604 ENOG4108JYZ YitT family BF90_2608 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BF90_261 ENOG4105VEQ Cold shock protein BF90_2610 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BF90_2611 ENOG4105KBJ sporulation protein ytfj BF90_2614 ENOG4105EFZ amidohydrolase BF90_2616 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF90_2621 ENOG4106KR7 LysR family Transcriptional regulator BF90_2623 ENOG4105U5Y Transcriptional regulator BF90_2624 ENOG4105U5Y Transcriptional regulator BF90_2626 ENOG4105C28 cystathionine BF90_2630 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF90_2632 ENOG4105EMN RNA polymerase sigma factor BF90_2635 ENOG4105F1V Acetoin utilization protein BF90_2636 ENOG4105W87 Cbs domain BF90_2637 ENOG4105DGU Histone deacetylase BF90_2639 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF90_2641 ENOG4107SNB ankyrin repeat protein YahD BF90_2642 ENOG4105EP9 oxidoreductase BF90_2648 ENOG4105ETE Transcriptional regulator (LacI family BF90_265 ENOG410667J hydrolase BF90_2652 ENOG4105C88 aminopeptidase BF90_2661 ENOG4108VDD TRNA binding domain protein BF90_2667 ENOG4105C8F Beta-lactamase domain protein BF90_2670 ENOG4108V15 phosphotransferase enzyme family BF90_2671 ENOG4108IUM Glycogen debranching enzyme BF90_2673 ENOG4107QSE Dipeptidase BF90_2674 ENOG4105YW5 deoR family transcriptional regulator BF90_2677 ENOG4105CBX hi0933 family BF90_2684 ENOG4108VJ1 Transcriptional regulator (CarD family BF90_2685 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BF90_2686 ENOG4105CSC Glucose uptake protein BF90_2689 ENOG4108ZAF Molybdopterin BF90_2690 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BF90_2691 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF90_2693 ENOG4105D06 uba thif-type nad fad binding protein BF90_2694 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF90_2698 ENOG41085GJ domain protein BF90_2700 ENOG4105DWV Homoserine O-trans-acetylase BF90_2702 ENOG4108B31 Spore germination protein BF90_2708 ENOG410605W Major Facilitator BF90_2709 ENOG4107S91 Sodium hydrogen exchanger BF90_2710 ENOG4105NCW Trka-c domain protein BF90_2713 ENOG4105C19 ABC transporter BF90_2717 ENOG4105N5T Radical SAM Protein BF90_2719 ENOG4105DA5 (ABC) transporter BF90_2725 ENOG4105E8V Alpha Beta Hydrolase Fold protein BF90_2726 ENOG4108Z0R Transferase BF90_2727 ENOG4105YVM Phosphoesterase, PA-phosphatase related BF90_2728 ENOG4105BZF Glycosyl transferase (Group 1 BF90_273 ENOG4107V2S Transcriptional regulator BF90_2730 ENOG4108RIR Molybdenum cofactor biosynthesis protein BF90_274 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF90_2740 ENOG4105EGD dinuclear metal center protein, YbgI family BF90_2741 ENOG4105BZU Histidine kinase BF90_2742 ENOG4105BZU Histidine kinase BF90_2743 ENOG4107S9D Alpha beta hydrolase BF90_2744 ENOG4107T7U Sulfatase BF90_2747 ENOG4105D2X ABC transporter substrate-binding protein BF90_2749 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BF90_2754 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF90_2760 ENOG4108V2W Carbonate dehydratase BF90_2762 ENOG4105C4M (Ubiquinol oxidase) subunit I BF90_2763 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF90_277 ENOG4105DND Transcriptional regulator BF90_2772 ENOG41087YS Phage shock protein A BF90_2779 ENOG4105BZU Histidine kinase BF90_278 ENOG4108RPX mosc domain containing protein BF90_2780 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF90_2785 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF90_2786 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BF90_2793 ENOG4107ZTW SNARE associated Golgi BF90_2796 ENOG4105C19 ABC transporter BF90_2797 ENOG41086D8 Transcriptional regulator BF90_2806 ENOG4105C6Z Gluconate BF90_2807 ENOG4105FDP GntR family transcriptional regulator BF90_281 ENOG4105BZ1 (ABC) transporter BF90_2811 ENOG41069H0 dihydroorotase EC 3.5.2.3 BF90_2817 ENOG4105DTQ mandelate racemase muconate lactonizing BF90_2819 ENOG4108IPT Naphthoate synthase BF90_282 ENOG4105BZ1 (ABC) transporter BF90_2820 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BF90_2821 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BF90_2822 ENOG4105E4F Isochorismate synthase BF90_2823 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF90_2825 ENOG4105VEQ Cold shock protein BF90_2830 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BF90_2832 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BF90_2834 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF90_2853 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BF90_286 ENOG4108JCI Transcriptional regulator BF90_2861 ENOG4105KT7 mgtC SapB transporter BF90_2863 ENOG4107PBV potassium channel BF90_2864 ENOG4107QYV phosphohexose isomerase BF90_2865 ENOG4105WG9 Conserved Protein BF90_2867 ENOG4105CHM Aminotransferase BF90_2868 ENOG4108ZB6 transcriptional regulator AsnC family BF90_2869 ENOG4105C5I Dehydrogenase BF90_2870 ENOG4108MUZ hydrolase BF90_2872 ENOG4105C87 Aminotransferase class I and II BF90_2875 ENOG4105Y38 Kinase-associated protein B BF90_2877 ENOG4107R3E Citrate transporter BF90_2880 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BF90_2881 ENOG4105KA0 thioesterase Superfamily protein BF90_2885 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF90_2889 ENOG41069ER domain protein BF90_2892 ENOG4105CEP NADH dehydrogenase BF90_2898 ENOG4105EWC Purine nucleoside phosphorylase BF90_2901 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BF90_2905 ENOG4108JJA ABC, transporter BF90_2906 ENOG4105C4B ABC transporter, permease BF90_2907 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BF90_2916 ENOG41083MR nifu domain-containing protein BF90_2919 ENOG4108W5N phosphatidylglycerophosphatase a BF90_292 ENOG4108KPJ rna polymerase sigma factor BF90_2921 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF90_2922 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF90_2925 ENOG4105CBT Fructose-1,6-bisphosphatase BF90_2927 ENOG4105MMD transcriptional regulator BF90_2929 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BF90_2930 ENOG4107TXC Transcriptional regulator BF90_2931 ENOG41090T1 Membrane BF90_2936 ENOG4105FAA peptidase M23 BF90_2938 ENOG4105KZD Domain of unknown function (DUF1805) BF90_2939 ENOG4107R8B 5'-nucleotidase BF90_2942 ENOG4105DIW FeS assembly protein SUFB BF90_2943 ENOG4108UNV SUF system FeS assembly protein, NifU family BF90_2944 ENOG4105C9B Cysteine desulfurase BF90_2945 ENOG4105JRK feS assembly protein SufD BF90_2946 ENOG4105C3K feS assembly ATPase SufC BF90_2947 ENOG4105D01 (LipO)protein BF90_2948 ENOG4105D01 (LipO)protein BF90_2949 ENOG4108UMI ABC transporter, permease BF90_2955 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF90_2956 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF90_2965 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF90_297 ENOG4105F32 YngK protein BF90_2971 ENOG4108W8B Beta-lactamase domain protein BF90_2972 ENOG4105C1G acyl-Coa dehydrogenase BF90_2973 ENOG4105CHU acetyl-coa acetyltransferase BF90_2976 ENOG4105DZ1 carboxypeptidase BF90_2980 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF90_2984 ENOG4108SUT Major Facilitator Superfamily BF90_2985 ENOG4107R7I amino acid BF90_2987 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF90_2989 ENOG4107AYK membrAne BF90_2996 ENOG4107ZTW SNARE associated Golgi BF90_2998 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF90_2999 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF90_3000 ENOG4105BZU Histidine kinase BF90_3002 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BF90_3005 ENOG4105VG1 fes assembly suf system protein BF90_3006 ENOG4105D4Y metalloprotease BF90_3010 ENOG4107S91 Sodium hydrogen exchanger BF90_3011 ENOG4105NCW Trka-c domain protein BF90_3013 ENOG4108RMU ferritin dps family protein BF90_3016 ENOG4108URH decarboxylase BF90_302 ENOG4105RD7 BadF BadG BcrA BcrD BF90_3021 ENOG4105D9N nucleoside BF90_3022 ENOG4105D9N nucleoside BF90_3025 ENOG4108RYK Nad-dependent epimerase dehydratase BF90_3030 ENOG4105CV8 reductase BF90_3031 ENOG4105F27 Major Facilitator BF90_3032 ENOG4105KVH Transcriptional regulator BF90_3035 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF90_3036 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF90_3037 ENOG4105D4A Cell wall formation (By similarity) BF90_3039 ENOG4105C8Q Methyl-accepting chemotaxis BF90_304 ENOG4107STF Involved in phosphonate degradation (By similarity) BF90_3041 ENOG4105WMR Protein CrcB homolog BF90_3042 ENOG4105WMR Protein CrcB homolog BF90_3045 ENOG4108MK9 spermidine N(1)-acetyltransferase BF90_3046 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BF90_3049 ENOG4108IPW abc transporter atp-binding protein BF90_3050 ENOG4105CM4 permease protein BF90_3055 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BF90_3057 ENOG4105XZU Preprotein translocase, subunit SecG BF90_3058 ENOG41067MG lrgb family BF90_3079 ENOG4105EFC phage portal protein HK97 family BF90_308 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF90_3083 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF90_3085 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BF90_3086 ENOG4105CP7 Triose-phosphate isomerase BF90_3091 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF90_3095 ENOG41090VF Stage v sporulation protein ac BF90_3096 ENOG4105CZ3 stage V sporulation protein ad BF90_3099 ENOG4105H67 Protein of unknown function (DUF421) BF90_31 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF90_3100 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF90_3101 ENOG4105KRI phosphocarrier protein (HPr BF90_3103 ENOG4105CHW UPF0052 protein BF90_3105 ENOG4108Z4K mutator MutT protein BF90_3107 ENOG4105C3M thioredoxin reductase BF90_3109 ENOG4108S4C acetyltransferase BF90_311 ENOG4105C1J atp-dependent rna helicase BF90_3113 ENOG41086DT Membrane protein of unknown function BF90_3115 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF90_3116 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BF90_3117 ENOG4105D7V transposase BF90_3120 ENOG4107TXC Transcriptional regulator BF90_3124 ENOG4105HMI Membrane BF90_3125 ENOG4105DUM transcriptional regulator, lysR family BF90_3126 ENOG4105DUM transcriptional regulator, lysR family BF90_3128 ENOG4108WS4 fmn reductase BF90_313 ENOG4108RZE Tetr family transcriptional regulator BF90_3131 ENOG4105BZ1 (ABC) transporter BF90_3133 ENOG4105CN1 protease BF90_3134 ENOG4105CRP Part of the ABC transporter FtsEX involved in BF90_3135 ENOG4105CAK Cell division ATP-binding protein ftsE BF90_3137 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BF90_3138 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BF90_3139 ENOG4105MS2 ribosomal subunit Interface protein BF90_3140 ENOG4105VEQ Cold shock protein BF90_3141 ENOG41081UC Inherit from COG: Competence protein BF90_3144 ENOG4105KVH Transcriptional regulator BF90_3146 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BF90_3147 ENOG4108KGH TRANSCRIPTIONal BF90_3148 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF90_3149 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF90_3150 ENOG4105ESV Glycosyl transferase, family 4 BF90_3152 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BF90_3155 ENOG410901P UPF0249 protein BF90_3156 ENOG4105F8D glycoside hydrolase family 4 BF90_3157 ENOG4105VCP PTS System BF90_3158 ENOG4105CK1 PTS System BF90_3160 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BF90_3161 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF90_3162 ENOG4105VCP PTS System BF90_3164 ENOG4105VZJ PTS System BF90_3167 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BF90_3168 ENOG4105ECB domain protein BF90_3169 ENOG4107RSM transcriptional regulator BF90_317 ENOG41088CC tellurite resistance protein tehB BF90_3177 ENOG4105DAA L-lactate BF90_3179 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BF90_3181 ENOG4105E0M Sulfatase BF90_3187 ENOG4107R8N Glycosyl transferase, family 2 BF90_3189 ENOG4105C94 Transporter BF90_319 ENOG4108I0C methyltransferase BF90_3190 ENOG41069ER domain protein BF90_3195 ENOG4105KBK Zinc finger, swim domain protein BF90_3196 ENOG4105C0D helicase BF90_320 ENOG4107RA9 decarboxylase BF90_3202 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF90_3204 ENOG4107RBB ABC transporter, permease BF90_3205 ENOG4105C19 ABC transporter BF90_3209 ENOG4105CXY transporter BF90_321 ENOG41090HR transcriptional regulator BF90_3212 ENOG4105BZU Histidine kinase BF90_3213 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF90_3214 ENOG4105CMR udp-glucose 4-epimerase BF90_3217 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF90_3218 ENOG4105EY8 ABC transporter BF90_3228 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BF90_3230 ENOG4105FRN stage II sporulation protein BF90_3233 ENOG4105DY9 regulatoR BF90_3234 ENOG4108IUW ABC transporter BF90_3238 ENOG4106778 Protein of unknown function (DUF1146) BF90_3239 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF90_3240 ENOG4105C8S subunit m BF90_3241 ENOG4105D65 subunit l BF90_3246 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF90_3247 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF90_3249 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF90_3250 ENOG4105BZU Histidine kinase BF90_3260 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BF90_3261 ENOG41062M3 atp synthase BF90_3266 ENOG4108YZG isomerase BF90_3269 ENOG4108VGI doxx family BF90_3270 ENOG4107XC4 flavin reductase domain protein, FMN-binding BF90_3273 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF90_3275 ENOG4108ZXQ stage ii sporulation protein r BF90_3276 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF90_3277 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BF90_3280 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BF90_3281 ENOG4105CBT Fructose-1,6-bisphosphatase BF90_3282 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BF90_3289 ENOG4105C1G acyl-Coa dehydrogenase BF90_329 ENOG4105CIN aminoacyl-histidine dipeptidase BF90_3290 ENOG4105C1G acyl-Coa dehydrogenase BF90_3291 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF90_3293 ENOG4105DF6 Fe-S oxidoreductase BF90_3296 ENOG4105BZU Histidine kinase BF90_3301 ENOG4105BZU Histidine kinase BF90_3302 ENOG4105KCT ABC transporter BF90_3303 ENOG4108M15 ABC transporter BF90_3304 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BF90_3307 ENOG4105IIU Aminopeptidase BF90_3311 ENOG4105EMN RNA polymerase sigma factor BF90_3313 ENOG410684U Domain of unknown function (DUF1934) BF90_3317 ENOG4105CYW agmatinase BF90_3319 ENOG4105DXB Major Facilitator superfamily BF90_3320 ENOG4107SWG transcriptional regulator MERR family BF90_3321 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF90_3322 ENOG4105BZ4 penicillin-binding protein BF90_3323 ENOG4108XFG YwhD family BF90_3324 ENOG4108Z4T Peptidase M50 BF90_3325 ENOG41069HH 4-oxalocrotonate tautomerase BF90_3326 ENOG4105DCI Phosphohydrolase BF90_3327 ENOG4108MES Periplasmic binding protein BF90_3328 ENOG4105E0A ABC, transporter BF90_3329 ENOG4105EHG Permease protein BF90_3330 ENOG4105DQ5 transport system permease protein BF90_3332 ENOG4108VCI transcription factor, rsfa family BF90_3335 ENOG4108IJ2 phosphate acetyltransferase BF90_3338 ENOG4108VKI Cell wall hydrolase BF90_3342 ENOG4107SVH Potassium channel protein BF90_3344 ENOG410667J hydrolase BF90_3345 ENOG4105VCH membrane BF90_3347 ENOG4108TU7 Inherit from COG: (ABC) transporter BF90_3348 ENOG4105CJ1 ABC, transporter BF90_3349 ENOG41090WU lipolytic protein G-D-S-L family BF90_335 ENOG4107RF6 penicillin-binding protein BF90_3352 ENOG4105D6E homoserine dehydrogenase BF90_3357 ENOG4108Y4K DNA-binding transcriptional activator BF90_3359 ENOG4105WH1 Two component transcriptional regulator luxr family BF90_336 ENOG4107RF6 penicillin-binding protein BF90_3360 ENOG4105BZU Histidine kinase BF90_3361 ENOG4105BZU Histidine kinase BF90_3362 ENOG4105DWF phosphomethylpyrimidine kinase BF90_3363 ENOG4105BZU Histidine kinase BF90_3364 ENOG4105VCD cytoplasmic protein BF90_3365 ENOG4105D22 carbon starvation protein BF90_3366 ENOG4105DY9 regulatoR BF90_3367 ENOG41079KZ Major Facilitator Superfamily BF90_3371 ENOG4105EN6 Membrane BF90_3372 ENOG4106YBV Methyl-accepting chemotaxis BF90_3374 ENOG4108S4H thioesterase Superfamily protein BF90_3376 ENOG4105JEU Glycosyl transferase, family 2 BF90_3377 ENOG4105C5H ABC transporter BF90_338 ENOG4105ETE Transcriptional regulator (LacI family BF90_3382 ENOG4105CKK Glycosyl transferase, family 2 BF90_3383 ENOG41067SE Tetr family transcriptional regulator BF90_3385 ENOG4105E0X reductase BF90_3386 ENOG4106F5Q Membrane BF90_3389 ENOG4105DY9 regulatoR BF90_339 ENOG4105IE8 Alpha-ketoglutarate permease BF90_3390 ENOG4108HRK Histidine kinase BF90_3391 ENOG4107RGD Major Facilitator superfamily BF90_3395 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF90_3397 ENOG4105IW1 AmiS UreI transporter BF90_3399 ENOG4105CMR udp-glucose 4-epimerase BF90_34 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF90_340 ENOG4105IE8 Alpha-ketoglutarate permease BF90_3400 ENOG4108UT2 hemolysin iii BF90_3402 ENOG4105C1J atp-dependent rna helicase BF90_3405 ENOG4105DPN Oligoendopeptidase f BF90_3406 ENOG4105DPN Oligoendopeptidase f BF90_341 ENOG4105CK5 oxidoreductase BF90_3410 ENOG4105C0H protease BF90_3411 ENOG4105Q2H domain protein BF90_3414 ENOG4105BZU Histidine kinase BF90_3415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF90_3421 ENOG4105CDU Replicative dna helicase BF90_3423 ENOG4105BZR domain protein BF90_3424 ENOG4108XMW Membrane BF90_3426 ENOG4108UUM single-stranded DNA-binding protein BF90_3428 ENOG4105C3G gtp-binding protein BF90_3429 ENOG4105VDK protein, conserved in bacteria BF90_3430 ENOG4105D8X mechanosensitive ion channel BF90_3431 ENOG4108ZDA Sporulation protein YyaC BF90_3432 ENOG4105FA0 parb-like partition protein BF90_3433 ENOG4107QJE Chromosome Partitioning Protein BF90_3437 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BF90_3439 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF90_3443 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF90_3444 ENOG410848D S4 domain protein YaaA BF90_3447 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF90_3455 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF90_346 ENOG4105D2N Aldolase BF90_3462 ENOG4105ZMH deoxynucleoside kinase BF90_3464 ENOG4105GTG Isochorismatase BF90_3465 ENOG4108Z6B deaminase BF90_3466 ENOG4105C6E dna polymerase iii BF90_3470 ENOG41067KS pro-sigma K processing BF90_3476 ENOG4105CXN decarboxylase BF90_3478 ENOG4105FA2 dna polymerase iii BF90_3479 ENOG4105MA4 psp1 domain protein BF90_3481 ENOG41060K3 Methyltransferase BF90_3483 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BF90_3484 ENOG4105KRN Transcriptional regulator, abrb family BF90_3486 ENOG4105F8V Hydrolase, tatD family BF90_3487 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BF90_3489 ENOG4105XFA sporulation peptidase YabG BF90_3490 ENOG4105W42 Veg protein BF90_3493 ENOG4105DFT pur operon repressor BF90_3494 ENOG4105KME endoribonuclease L-psp BF90_3497 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BF90_3498 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BF90_35 ENOG4105C5S asparaginyl-tRNA synthetase BF90_3500 ENOG4108JA2 transcriptioN-repair coupling factor BF90_3501 ENOG4108M14 stage v sporulation protein t BF90_3503 ENOG4108IY2 MazG family BF90_3504 ENOG41082I2 s4 domain protein BF90_3505 ENOG4105VYY sporulation protein yabp BF90_3508 ENOG41060GV RNA binding s1 domain protein BF90_351 ENOG4105CGH 5'-nucleotidase BF90_3512 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BF90_3513 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF90_3514 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BF90_3517 ENOG4105C6T cysteine synthase BF90_3518 ENOG4105CRQ synthase (Component I) BF90_3519 ENOG4105DDQ anthranilate synthase BF90_3520 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BF90_3521 ENOG4105EEI dihydropteroate synthase BF90_3522 ENOG4105KRF dihydroneopterin aldolase BF90_3523 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BF90_3525 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BF90_3532 ENOG4108Z0C Uvrb UvrC protein BF90_3535 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BF90_3537 ENOG4105CTP PilT protein domain protein BF90_354 ENOG4105VZ8 Transcriptional regulator BF90_3541 ENOG4105D7W serine acetyltransferase BF90_3544 ENOG4105C2N RNA methyltransferase TrmH family group 3 BF90_3545 ENOG4105M0M Tetracycline resistance protein BF90_3546 ENOG4105QIV RNA polymerase BF90_3548 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BF90_3553 ENOG4107Y49 methyltransferase BF90_3555 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BF90_3556 ENOG4105XPM ribosomal protein BF90_357 ENOG4108VXD carboxy-peptidase BF90_3577 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BF90_3582 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF90_3584 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF90_3586 ENOG41067V7 50S ribosomal protein L36 BF90_3592 ENOG4108JJB ABC transporter BF90_3593 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF90_3594 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF90_3599 ENOG4105D1F ATP-binding protein BF90_3602 ENOG4108NMV polysaccharide deacetylase BF90_362 ENOG41067SE Tetr family transcriptional regulator BF90_3620 ENOG4105C8B TIGR00159 family BF90_3621 ENOG4107U5W ybbr family BF90_3623 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BF90_3624 ENOG4108VQT Alpha beta hydrolase fold protein BF90_3626 ENOG4105CMG Carbohydrate kinase BF90_3628 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BF90_3629 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BF90_363 ENOG4105C5H ABC transporter BF90_3636 ENOG4108PSK reductase BF90_3637 ENOG4108UMI ABC transporter, permease BF90_3638 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF90_3639 ENOG4105D01 (LipO)protein BF90_3640 ENOG4105EE1 crotonyl-CoA reductase BF90_3642 ENOG4105IQ5 FAD linked oxidase domain protein BF90_3643 ENOG4105IQ5 FAD linked oxidase domain protein BF90_3646 ENOG4105C2C drug resistance transporter, Bcr CflA BF90_3649 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF90_365 ENOG4105BZU Histidine kinase BF90_3650 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF90_3651 ENOG4105C3U ABC transporter BF90_3652 ENOG4108JQ7 (ABC) transporter BF90_3658 ENOG4108J59 Extracellular solute-binding protein, family 5 BF90_3659 ENOG4108J59 Extracellular solute-binding protein, family 5 BF90_3661 ENOG4105II7 pyrroline-5-carboxylate reductase BF90_3662 ENOG4107XDY Nicotinamide Mononucleotide Transporter BF90_3664 ENOG4105E0C molybdate abc transporter BF90_3665 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF90_3666 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BF90_3669 ENOG4105EGI Transcriptional regulator BF90_367 ENOG4106ANW SMI1_KNR4 BF90_3673 ENOG4105F6E Acyl-transferase BF90_3677 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF90_3680 ENOG4108RE7 deoxyribonuclease BF90_3681 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BF90_3685 ENOG4105C5H ABC transporter BF90_3688 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BF90_3690 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF90_3691 ENOG4105C3U ABC transporter BF90_3692 ENOG4108JQ7 (ABC) transporter BF90_3693 ENOG410667J hydrolase BF90_3699 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BF90_370 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BF90_3700 ENOG4105ERH Fumarylacetoacetate hydrolase BF90_3702 ENOG4108SC4 )-transporter BF90_3703 ENOG4105CPF Cell wall formation (By similarity) BF90_3704 ENOG4105CPF Cell wall formation (By similarity) BF90_3705 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF90_3707 ENOG4107ZXI Rhomboid family BF90_3710 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BF90_3711 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF90_3713 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BF90_373 ENOG4105CJ1 ABC, transporter BF90_3733 ENOG4105K8N protein family UPF0079, ATPase BF90_3734 ENOG41072GX Peptidase M22 Glycoprotease BF90_3735 ENOG410801F ribosomal-protein-alanine acetyltransferase BF90_3736 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF90_3737 ENOG4105C5H ABC transporter BF90_3740 ENOG4108TYN CAAX amino terminal protease family protein BF90_3744 ENOG4105C7N Xanthine uracil vitamin C permease BF90_3746 ENOG4105BZU Histidine kinase BF90_375 ENOG4107Z3H Transcriptional regulator, TetR family BF90_3751 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF90_3755 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF90_3760 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BF90_3761 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BF90_3762 ENOG4105C83 adenylosuccinate lyase BF90_3764 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BF90_3769 ENOG4108V3E phosphoribosylglycinamide formyltransferase BF90_3771 ENOG4105C12 Phosphoribosylglycinamide synthetase BF90_3776 ENOG4105C4R Atp-dependent dna helicase BF90_378 ENOG4105C1G acyl-Coa dehydrogenase BF90_3782 ENOG4108W2Y isochorismatase BF90_3783 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF90_3784 ENOG4108UMI ABC transporter, permease BF90_3785 ENOG4105D01 (LipO)protein BF90_3789 ENOG4105D0U Arsenite-activated ATPase (ArsA) BF90_379 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF90_3790 ENOG410834F Transcriptional regulator BF90_3791 ENOG4107I77 yiaA/B two helix domain BF90_3795 ENOG4105CBD Diacylglycerol kinase BF90_3796 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BF90_3797 ENOG4108JPW Aminotransferase BF90_3799 ENOG4105C26 Dehydrogenase BF90_380 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BF90_3800 ENOG4105KPY Small multidrug resistance protein BF90_3804 ENOG4105D9N nucleoside BF90_3805 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF90_3808 ENOG4108W15 Protein of unknown function (DUF1456) BF90_381 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BF90_3811 ENOG4105DTQ mandelate racemase muconate lactonizing BF90_3812 ENOG4105DFD Na H antiporter BF90_3817 ENOG4105D3R alkyl hydroperoxide reductase BF90_3818 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BF90_382 ENOG4105E39 Enoyl-CoA hydratase BF90_3820 ENOG4107W7X Aldolase BF90_3821 ENOG4105EHG Permease protein BF90_3822 ENOG4105DQ5 transport system permease protein BF90_3823 ENOG4108V5C ABC transporter BF90_3827 ENOG4106UIA BF90_3828 ENOG4106UIA BF90_383 ENOG4107QX3 carboxylase BF90_3832 ENOG4105BZU Histidine kinase BF90_3836 ENOG410756H nucleotidyltransferase BF90_3837 ENOG4105D2S major facilitator superfamily BF90_384 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF90_3840 ENOG4105E5Q amino acid AbC transporter BF90_3841 ENOG4105EAB amino acid AbC transporter BF90_3843 ENOG4105C8Q Methyl-accepting chemotaxis BF90_3844 ENOG4105C8Q Methyl-accepting chemotaxis BF90_3846 ENOG4105CI1 PTS System BF90_3852 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BF90_3855 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF90_3858 ENOG4105C5H ABC transporter BF90_386 ENOG4105WCN acetyltransferase BF90_3864 ENOG41062JF Transcriptional regulator BF90_3868 ENOG4105DEU major facilitator superfamily BF90_387 ENOG4105DBI uridine monophosphokinase BF90_3871 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BF90_3874 ENOG4108N0M stress protein BF90_3875 ENOG4106FN3 tellurium resistance protein BF90_3876 ENOG4106FN3 tellurium resistance protein BF90_3877 ENOG4107TS3 membrane protein, TerC BF90_3878 ENOG4108TTB tellurium resistance protein BF90_3882 ENOG4105KJF protein tyrosine phosphatase BF90_3884 ENOG4107U9T Pfam:Ribonuclease_BN BF90_3885 ENOG4105C59 p-type ATPase BF90_3886 ENOG4108IPJ Membrane BF90_3890 ENOG4107ZTW SNARE associated Golgi BF90_3893 ENOG410606W general stress protein BF90_3894 ENOG4105UPD Calcium Proton BF90_39 ENOG4105EC2 ftsk spoIIIe BF90_390 ENOG4105DZ1 carboxypeptidase BF90_3902 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF90_3903 ENOG4105VTR Integrase BF90_393 ENOG4105T9C HD domain BF90_395 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF90_3962 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF90_3964 ENOG4108JUB Transcriptional regulator BF90_3966 ENOG4108IQI permease BF90_3972 ENOG4105CSV Glutaminase BF90_3974 ENOG4108A04 Beta-lactamase BF90_3977 ENOG4105CKK Glycosyl transferase, family 2 BF90_3979 ENOG4107QQG Dehydrogenase BF90_3980 ENOG4105C3I Nad-dependent epimerase dehydratase BF90_3983 ENOG4105F1A Pyruvate formate-lyase BF90_3987 ENOG4105CI2 imidazolone-5-propionate hydrolase BF90_3988 ENOG4105ECP epimerase BF90_3994 ENOG41067AE Membrane-bound metal-dependent hydrolase BF90_3995 ENOG4105CEN a g-specific adenine glycosylase BF90_3996 ENOG4106BXE BF90_4000 ENOG4105BZ1 (ABC) transporter BF90_4001 ENOG4107NBY Membrane BF90_4002 ENOG4105CBC glutamate synthase BF90_4004 ENOG4108IUW ABC transporter BF90_4008 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF90_4009 ENOG4105G5W regulator Fur family BF90_4034 ENOG4108JQC penicillin-binding protein 1A BF90_4035 ENOG4107ZQN disulfide bond BF90_4037 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BF90_4039 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BF90_404 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF90_404 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF90_4040 ENOG4105BZU Histidine kinase BF90_4042 ENOG4105CYN Serine protein kinase BF90_4046 ENOG4105C94 Transporter BF90_4049 ENOG4105DZ6 Band 7 protein BF90_4051 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BF90_4052 ENOG4108MRH transcriptional regulatory protein BF90_4053 ENOG4105D4T Citrate transporter BF90_4057 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF90_4058 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF90_4059 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BF90_4060 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BF90_4061 ENOG4105BZ7 extracellular solute-binding protein family 1 BF90_4063 ENOG4108STX response regulator BF90_4064 ENOG4105US7 Histidine kinase BF90_4069 ENOG4108MRH transcriptional regulatory protein BF90_407 ENOG4105FQP Beta-lactamase BF90_4071 ENOG4105C6K Malic enzyme BF90_4073 ENOG4108UZ3 Transporter BF90_4074 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF90_4076 ENOG4105BZU Histidine kinase BF90_4077 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF90_4079 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF90_4080 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF90_4081 ENOG4108JB9 formate dehydrogenase BF90_4086 ENOG4105CUB amino acid BF90_4088 ENOG4105C59 p-type ATPase BF90_4089 ENOG4105DAP Nicotinate phosphoribosyltransferase BF90_409 ENOG4107Y80 Major Facilitator superfamily BF90_4096 ENOG41073R8 VanW family BF90_4097 ENOG4108KGH TRANSCRIPTIONal BF90_4098 ENOG4105D9N nucleoside BF90_4099 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BF90_4100 ENOG4105C37 (CBS) domain BF90_4101 ENOG4108IJ0 Aspartate ammonia-lyase BF90_4102 ENOG4105DAA L-lactate BF90_4105 ENOG4105DUX Transporter BF90_4106 ENOG4108MES Periplasmic binding protein BF90_4107 ENOG4105DQ5 transport system permease protein BF90_4108 ENOG4108IHU transport system permease protein BF90_4109 ENOG4105E0A ABC, transporter BF90_4110 ENOG4105DMQ Methyltransferase BF90_4112 ENOG4105EXW epimerase dehydratase BF90_4114 ENOG4107T89 von Willebrand factor, type A BF90_4115 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BF90_4116 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF90_4119 ENOG4105BZU Histidine kinase BF90_4120 ENOG4105D5Q Arginine ornithine antiporter BF90_4121 ENOG4107414 GntR family transcriptional regulator BF90_4122 ENOG4105C5Y PTS System BF90_4123 ENOG4105CG3 alpha amylase, catalytic region BF90_4126 ENOG4105E1K spore germination protein BF90_4128 ENOG4105CRN Aminoglycoside phosphotransferase BF90_4129 ENOG4105BZG amino acid carrier protein BF90_413 ENOG4105CUV Homoserine Kinase BF90_4130 ENOG4105CDA abc transporter atp-binding protein BF90_4131 ENOG4105CT1 (ABC) transporter BF90_4132 ENOG4105EAD ABC transporter BF90_4133 ENOG4105DRP amino acid AbC transporter BF90_4134 ENOG4108IQI permease BF90_4139 ENOG4105D29 Helix-turn-helix type 11 domain protein BF90_4140 ENOG4105NAE bifunctional deaminase-reductase domain protein BF90_4141 ENOG4105BZU Histidine kinase BF90_4144 ENOG4105CHH sulfate transporter BF90_4145 ENOG41068KF Universal stress protein BF90_4147 ENOG4105DEF Extracellular solute-binding protein, family 5 BF90_4149 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF90_4150 ENOG4108JQ7 (ABC) transporter BF90_4152 ENOG4105CXY transporter BF90_4153 ENOG41067TZ transcriptional regulator, MarR family BF90_4154 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF90_4155 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF90_4156 ENOG4105ETE Transcriptional regulator (LacI family BF90_4157 ENOG4108RVA ribokinase BF90_4159 ENOG4105C2J ABC transporter BF90_4160 ENOG4105CNN ABC, transporter BF90_4161 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BF90_4162 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF90_4174 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF90_4175 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF90_4176 ENOG41069ER domain protein BF90_4177 ENOG4105VZ8 Transcriptional regulator BF90_4178 ENOG4107D63 BF90_4180 ENOG4105DUX Transporter BF90_4184 ENOG4105C85 amino acid BF90_4185 ENOG4105C7N Xanthine uracil vitamin C permease BF90_419 ENOG4105CPQ Dehydrogenase BF90_4193 ENOG4105BZ9 Cytochrome C oxidase, subunit I BF90_4194 ENOG4105E2S oxidase) subunit II BF90_4197 ENOG4106CAD Protein of unknown function (DUF3311) BF90_4198 ENOG4105E1V na solute symporter BF90_4201 ENOG4108NHD germination protein BF90_4202 ENOG4105CE1 Ferrous iron transport protein b BF90_4203 ENOG4105CE1 Ferrous iron transport protein b BF90_4204 ENOG4105CE1 Ferrous iron transport protein b BF90_4205 ENOG4105CVA phosphate BF90_4206 ENOG4105C8U phosphate abc transporter BF90_4207 ENOG4105E2Z phosphate ABC transporter (Permease BF90_422 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF90_423 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF90_4234 ENOG41080XQ Signal transduction protein with cbs domains BF90_4238 ENOG4105ETU transcriptional activator (TenA BF90_4240 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF90_4242 ENOG4108VEU Thiamine monophosphate synthase BF90_4243 ENOG41080HI glycine oxidase BF90_4246 ENOG4105D06 uba thif-type nad fad binding protein BF90_4247 ENOG4105DWF phosphomethylpyrimidine kinase BF90_4256 ENOG4108INS Transcriptional regulator BF90_4259 ENOG4105C7N Xanthine uracil vitamin C permease BF90_4261 ENOG4108PXI ErfK YbiS YcfS YnhG BF90_4265 ENOG4105C5Y PTS System BF90_4272 ENOG4108B31 Spore germination protein BF90_4276 ENOG4107Y03 Nitroreductase BF90_4277 ENOG4105ED1 spovr family BF90_4282 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BF90_4283 ENOG4105XTG Pfam:DUF156 BF90_4284 ENOG4105VFE sira family BF90_4285 ENOG4107TPS domain protein BF90_4286 ENOG4105VFE sira family BF90_4288 ENOG41085GJ domain protein BF90_4290 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BF90_4291 ENOG41087NI Sulfite exporter TauE/SafE BF90_4293 ENOG4108KGH TRANSCRIPTIONal BF90_4298 ENOG4105EMD TRANSCRIPTIONal BF90_4299 ENOG4105VCP PTS System BF90_4300 ENOG4105VZJ PTS System BF90_4304 ENOG41069ER domain protein BF90_4305 ENOG4107RBB ABC transporter, permease BF90_4306 ENOG4105C19 ABC transporter BF90_4312 ENOG4105WEF catalase BF90_4319 ENOG4107T5V SNARE associated Golgi BF90_4326 ENOG4105CUB amino acid BF90_4327 ENOG4107RWR Sodium hydrogen exchanger BF90_4329 ENOG4106KNT transcriptional regulator BF90_4336 ENOG4108PCN EamA-like transporter family BF90_4337 ENOG4108YXU transcriptional regulator AsnC family BF90_4339 ENOG4105KPY Small multidrug resistance protein BF90_4340 ENOG4105KPY Small multidrug resistance protein BF90_4345 ENOG4105NF4 modulator of drug activity BF90_4346 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF90_4347 ENOG4105E5W Transporter BF90_4349 ENOG4107RKG DJ-1/PfpI family BF90_4350 ENOG4105CH6 catalase BF90_4352 ENOG4105D5Q Arginine ornithine antiporter BF90_4353 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BF90_4355 ENOG4105C26 Dehydrogenase BF90_4356 ENOG4105BZ1 (ABC) transporter BF90_4357 ENOG4105BZ1 (ABC) transporter BF90_4358 ENOG4105BZ1 (ABC) transporter BF90_4360 ENOG4105DRP amino acid AbC transporter BF90_4361 ENOG4105CDA abc transporter atp-binding protein BF90_4364 ENOG410839P BF90_4371 ENOG4107FQX Alpha-acetolactate decarboxylase BF90_4376 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF90_4378 ENOG4105D4P Coproporphyrinogen iii oxidase BF90_4381 ENOG4105CHH sulfate transporter BF90_4389 ENOG4106AKK s-layer domain-containing protein BF90_4391 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF90_4392 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF90_4395 ENOG4105CGU Enoyl-CoA hydratase BF90_4398 ENOG4105DER m42 family BF90_4402 ENOG4105CTU Proline racemase BF90_4410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF90_4413 ENOG4108JQ7 (ABC) transporter BF90_4419 ENOG4105CSH Transporter BF90_4421 ENOG4108MRH transcriptional regulatory protein BF90_4430 ENOG4105CDU Replicative dna helicase BF90_4438 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF90_444 ENOG4105ETU transcriptional activator (TenA BF90_4449 ENOG4107P5I polyketide synthase BF90_4450 ENOG4108IG5 Transcriptional regulator BF90_4454 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF90_4458 ENOG4105CMT Dihydroxyacetone kinase BF90_4460 ENOG4105CMT Dihydroxyacetone kinase BF90_4461 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF90_4462 ENOG410847I Transcriptional regulator, BadM Rrf2 family BF90_4467 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BF90_4481 ENOG4105WN5 stage II sporulation protein BF90_4483 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF90_4485 ENOG4108MJI response regulator BF90_4486 ENOG4105BZU Histidine kinase BF90_4487 ENOG4105BZU Histidine kinase BF90_4492 ENOG4105K8R UPF0145 protein BF90_4498 ENOG4107VRP DNA repair exonuclease BF90_4499 ENOG4106D4I domain protein BF90_4500 ENOG4105D7V transposase BF90_4503 ENOG4108IND Tetr family transcriptional regulator BF90_4504 ENOG4105EQ0 Major Facilitator superfamily BF90_4509 ENOG4108MUZ hydrolase BF90_4514 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF90_4517 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BF90_4520 ENOG4105EMN RNA polymerase sigma factor BF90_4525 ENOG4105C57 major facilitator superfamily BF90_4526 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF90_4528 ENOG4105EEM helicase BF90_4529 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF90_4534 ENOG4105K59 histidine triad (HIT) protein BF90_4541 ENOG410905X membrane-flanked domain protein BF90_4543 ENOG4105CKV Membrane BF90_4552 ENOG410905X membrane-flanked domain protein BF90_4553 ENOG4105CKV Membrane BF90_4554 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BF90_4555 ENOG4105BZ4 penicillin-binding protein BF90_4556 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BF90_4558 ENOG4105C1Q protoporphyrinogen oxidase BF90_4563 ENOG4105NA0 Transcriptional regulator BF90_4566 ENOG4105ECB domain protein BF90_4572 ENOG4106AXD BF90_4573 ENOG4108RQ5 Beta-lactamase domain-containing protein BF90_4574 ENOG4105DF9 Lipoate-protein, ligase BF90_4576 ENOG4105CEY Amp-dependent synthetase and ligase BF90_4582 ENOG4105CNA YD repeat protein BF90_4587 ENOG4105ENX hydrolase BF90_4589 ENOG4107RN3 metallophosphoesterase BF90_4590 ENOG4107TVP HD domain protein BF90_4592 ENOG4108AEY RNA polymerase sigma factor BF90_4593 ENOG41086D8 Transcriptional regulator BF90_4597 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF90_4602 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BF90_4603 ENOG4105C8Q Methyl-accepting chemotaxis BF90_4607 ENOG4105ZU5 s-layer protein BF90_4608 ENOG4107QP3 malate synthase g BF90_4611 ENOG4105VEQ Cold shock protein BF90_4614 ENOG4105XVF Competence transcription factor BF90_4617 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BF90_4618 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BF90_4627 ENOG4105ERH Fumarylacetoacetate hydrolase BF90_4632 ENOG4105CAQ asparagine synthetase BF90_4633 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BF90_4634 ENOG4105CH6 catalase BF90_4635 ENOG4105BZU Histidine kinase BF90_4640 ENOG4105QNR S1 RNA binding domain protein BF90_4642 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF90_4644 ENOG4107AYK membrAne BF90_4645 ENOG41073B9 BF90_4647 ENOG4108KP7 hydrolase BF90_4649 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BF90_4654 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF90_4655 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF90_4658 ENOG4105C31 Tryptophanyl-tRNA synthetase BF90_4661 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF90_4662 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF90_4664 ENOG4108JQ7 (ABC) transporter BF90_4665 ENOG4105UQX Mate efflux family protein BF90_4669 ENOG4108ZCF integral membrane protein BF90_467 ENOG410667J hydrolase BF90_4671 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF90_4673 ENOG4105DPN Oligoendopeptidase f BF90_4676 ENOG4108Z18 K06886 hemoglobin BF90_4677 ENOG4105MIX Adenylate cyclase BF90_4680 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BF90_4681 ENOG4105EMS pseudouridine synthase BF90_4684 ENOG4105CNI cell division protein FtsW BF90_4686 ENOG4105K64 Glycosyl transferase, family 2 BF90_469 ENOG4105BZU Histidine kinase BF90_4690 ENOG4107TVC Glycosyl transferase, family 2 BF90_4695 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BF90_4696 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BF90_4698 ENOG4105C1B dTDP-glucose 4-6-dehydratase BF90_4699 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BF90_470 ENOG4107RF6 penicillin-binding protein BF90_4708 ENOG4108WVJ 2'-5' rna ligase BF90_4713 ENOG4105CK7 Sodium proline symporter BF90_4714 ENOG4105CRQ synthase (Component I) BF90_4715 ENOG4105DDQ anthranilate synthase BF90_4733 ENOG4105C7S Dehydrogenase BF90_4735 ENOG4105VZ8 Transcriptional regulator BF90_474 ENOG4108JJB ABC transporter BF90_4746 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BF90_4748 ENOG4105DZ1 carboxypeptidase BF90_4749 ENOG4105VFR signal peptidase BF90_4755 ENOG4105C26 Dehydrogenase BF90_4756 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF90_4757 ENOG4105F38 ABC transporter, permease BF90_4758 ENOG4105D38 putrescine abc transporter BF90_4759 ENOG4107RUE extracellular solute-binding protein family 1 BF90_4761 ENOG4105EYF MMPL domain protein BF90_4763 ENOG4108YBP pseudouridine synthase BF90_4765 ENOG4105K4I Scp-like extracellular BF90_4766 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF90_4767 ENOG4105CQB FAD linked oxidase domain protein BF90_477 ENOG4108HGU Histidine kinase BF90_4770 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF90_4771 ENOG4105BZU Histidine kinase BF90_4772 ENOG4105JXH GntR family transcriptional regulator BF90_4776 ENOG4106A3R peptidase BF90_4778 ENOG4108QTI )-transporter BF90_4779 ENOG4107TS3 membrane protein, TerC BF90_4781 ENOG4105CZN Potassium uptake protein BF90_4782 ENOG410681C small acid-soluble spore protein BF90_4783 ENOG4108Z7G MaoC domain protein dehydratase BF90_4787 ENOG4105CHR reductase BF90_4789 ENOG4105MWK D-amino acid dehydrogenase, small subunit BF90_4793 ENOG4105C4Y ABC transporter BF90_4795 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF90_4798 ENOG4107RCV ABC transporter, permease BF90_4799 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BF90_480 ENOG4105CB2 alcohol dehydrogenase BF90_4803 ENOG4105E98 transcriptional regulator DeoR family BF90_4808 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF90_4809 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF90_481 ENOG4105CJN penicillin-binding protein BF90_4811 ENOG4105PXI polysaccharide deacetylase BF90_4813 ENOG4105BZU Histidine kinase BF90_4814 ENOG41090MY MarR family Transcriptional regulator BF90_4816 ENOG4106DF1 BF90_4818 ENOG4105BZU Histidine kinase BF90_4820 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BF90_4821 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BF90_4829 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BF90_483 ENOG4105FQP Beta-lactamase BF90_4830 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF90_4832 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF90_4833 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF90_4834 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF90_4835 ENOG4105CZV ABC transporter BF90_4837 ENOG4105CJ1 ABC, transporter BF90_4845 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF90_4846 ENOG4105EA8 2-Nitropropane dioxygenase BF90_4847 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF90_4849 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF90_4854 ENOG4105NQC Flavodoxin BF90_4861 ENOG4107QMU Mate efflux family protein BF90_4862 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF90_4868 ENOG4105CZN Potassium uptake protein BF90_4869 ENOG41063Y9 BF90_4870 ENOG4105KBJ sporulation protein ytfj BF90_4875 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF90_4876 ENOG4105C7K acetolactate synthase BF90_4877 ENOG4108ZP8 Acetolactate synthase small subunit BF90_4878 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF90_4880 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BF90_4885 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BF90_4892 ENOG4107RVV histidinol phosphate phosphatase, hisj family BF90_4895 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF90_4896 ENOG4105E0M Sulfatase BF90_4898 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BF90_490 ENOG4108V4B ThiJ pfpI BF90_4902 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BF90_4903 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BF90_4905 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF90_4906 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF90_4907 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF90_4908 ENOG4105C8J )-transporter BF90_4912 ENOG4105DFD Na H antiporter BF90_4916 ENOG4105ENE Histidine kinase BF90_4917 ENOG4105WH1 Two component transcriptional regulator luxr family BF90_4921 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BF90_4926 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BF90_4930 ENOG4105CJ3 phosphate transporter BF90_4931 ENOG4107GRR phosphate transport regulator BF90_4932 ENOG4105BZ4 penicillin-binding protein BF90_4935 ENOG4105BZU Histidine kinase BF90_4936 ENOG4105I3N Conserved Protein BF90_4939 ENOG4105BZU Histidine kinase BF90_4946 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF90_4947 ENOG4105DZ1 carboxypeptidase BF90_4948 ENOG4108JIC nucleoside recognition domain protein BF90_495 ENOG4107Y80 Major Facilitator superfamily BF90_4950 ENOG4105FE9 pseudouridine synthase BF90_4952 ENOG4107TWT Cytochrome c biogenesis protein BF90_4953 ENOG4105CRE cytochrome C BF90_4954 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF90_4955 ENOG4105BZU Histidine kinase BF90_4956 ENOG4108WBT adenosyltransferase BF90_4959 ENOG4108SAX Membrane BF90_4961 ENOG4105T7X BF90_4962 ENOG4105C9U ATP-dependent DNA helicase RecQ BF90_4963 ENOG4105I7S Abortive infection protein BF90_4965 ENOG4107RGJ metallophosphoesterase BF90_4966 ENOG4107X2D transcriptional regulator, merr family BF90_4967 ENOG4108S6Z Negative regulator of genetic competence BF90_4972 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BF90_4973 ENOG4107RB3 L-asparaginase BF90_4980 ENOG4105S2F BF90_4981 ENOG41065D1 BF90_4987 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BF90_499 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF90_4990 ENOG4105XXQ heptaprenyl diphosphate synthase component I BF90_4992 ENOG4105EAH synthase BF90_4996 ENOG4105CIH Imidazole acetol-phosphate transaminase BF90_4997 ENOG41068YB TPR repeat-containing protein BF90_5000 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BF90_5001 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BF90_5002 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BF90_5008 ENOG4108JYZ YitT family BF90_5009 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BF90_5012 ENOG4105FJR Lmbe family BF90_5013 ENOG4105CPK Glycosyl transferase (Group 1 BF90_5020 ENOG4105DVT helicase BF90_5021 ENOG4105DVT helicase BF90_5022 ENOG4105YAC BF90_5026 ENOG4105CSM endonuclease III BF90_5028 ENOG4105BZ4 penicillin-binding protein BF90_5039 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BF90_504 ENOG4107Y9U Membrane BF90_5041 ENOG4105DVT helicase BF90_5042 ENOG4105CTD carboxy-peptidase BF90_5045 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF90_5047 ENOG4105C2W permease BF90_5048 ENOG4105DHF Membrane BF90_505 ENOG4107Y9U Membrane BF90_5050 ENOG410890F Dynamin family BF90_5052 ENOG4108W0I acetyltransferase BF90_5054 ENOG4105KHC sulfurtransferase BF90_5057 ENOG4106032 Glutathionylspermidine synthase BF90_5071 ENOG4105CPK Glycosyl transferase (Group 1 BF90_5074 ENOG4108SZE gCN5-related N-acetyltransferase BF90_5078 ENOG41081VK Ribonuclease BF90_5091 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF90_5093 ENOG4107RWR Sodium hydrogen exchanger BF90_5094 ENOG4105CN5 Metallo-Beta-Lactamase BF90_5095 ENOG4108Z5V transcriptional regulator, merr family BF90_5097 ENOG4105H67 Protein of unknown function (DUF421) BF90_5098 ENOG41080C8 DUF218 domain BF90_5109 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF90_5111 ENOG4107R0U MotA TolQ exbB proton channel BF90_5112 ENOG4105ER2 Ompa motb domain protein BF90_5113 ENOG4107YTP response regulator receiver protein BF90_5114 ENOG4105CBS Chea signal transduction histidine kinase BF90_5115 ENOG4105CBS Chea signal transduction histidine kinase BF90_5116 ENOG4105DD5 Flagellar motor switch protein BF90_5119 ENOG4105BZU Histidine kinase BF90_512 ENOG4105FCD Major Facilitator BF90_5124 ENOG4105E1Q flagellar hook-associated protein BF90_5125 ENOG4105DTJ flagellar hook-associated protein BF90_5130 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BF90_5131 ENOG4108ZC9 flagellar basal-body rod protein flgc BF90_5132 ENOG41075Z6 flagellar hook-basal body complex protein fliE BF90_5133 ENOG4107U2N Flagellar M-ring protein BF90_5135 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF90_514 ENOG4105E09 nadh pyrophosphatase BF90_5142 ENOG4105BZE flagellar hook protein, FlgE BF90_5146 ENOG4107R88 Chemotaxis protein (CheV) BF90_5148 ENOG4105K64 Glycosyl transferase, family 2 BF90_515 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF90_5154 ENOG4107TVC Glycosyl transferase, family 2 BF90_5159 ENOG4105I03 Flagellin BF90_516 ENOG4108Z4K mutator MutT protein BF90_5160 ENOG4105E4C Lytic transglycosylase catalytic BF90_5161 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF90_5163 ENOG4105DD5 Flagellar motor switch protein BF90_5165 ENOG4105CN7 Flagellar biosynthetic protein FliP BF90_5166 ENOG4105VS8 Flagellar biosynthetic protein fliq BF90_5169 ENOG4105D00 flagellar biosynthetic protein flhB BF90_5170 ENOG4105D7B Flagellar biosynthesis protein flha BF90_5171 ENOG4105FZW flagellar biosynthesis regulator FlhF BF90_5172 ENOG4105KTQ flagellar basal-body rod protein BF90_5173 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF90_5178 ENOG4108RZE Tetr family transcriptional regulator BF90_5182 ENOG4105KAC Antibiotic biosynthesis monooxygenase BF90_5187 ENOG4105DUM transcriptional regulator, lysR family BF90_5188 ENOG4108KB2 LysR family Transcriptional regulator BF90_5189 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF90_5190 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF90_5191 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BF90_5192 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BF90_5199 ENOG4105CVJ phosphoglycerate mutase BF90_5206 ENOG4105CAQ asparagine synthetase BF90_5210 ENOG4105PGM cation diffusion facilitator family transporter BF90_5212 ENOG4105DRR Transcriptional regulator, GntR family BF90_5213 ENOG4108UZ3 Transporter BF90_5214 ENOG4105CKI cobalamin synthesis protein BF90_5215 ENOG4108PJD permease BF90_5218 ENOG4105DFD Na H antiporter BF90_5219 ENOG4105C9Q fumarate hydratase class II BF90_5223 ENOG4107QJQ Mate efflux family protein BF90_5224 ENOG4107QJQ Mate efflux family protein BF90_5225 ENOG4105EC3 peptidase S51, dipeptidase E BF90_5229 ENOG4107QIV Cytochrome c biogenesis protein BF90_523 ENOG4108XI2 Domain of unknown function (DUF1963) BF90_5236 ENOG4106BRA Membrane BF90_5243 ENOG4105CJ1 ABC, transporter BF90_5247 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BF90_5249 ENOG4108IJ0 Aspartate ammonia-lyase BF90_5250 ENOG4105C6K Malic enzyme BF90_5264 ENOG4105FVX BF90_5273 ENOG4105CSR polyphosphate kinase 2 BF90_5274 ENOG4105DXI Major Facilitator superfamily BF90_5277 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF90_5280 ENOG4105EU0 Major facilitator Superfamily BF90_5281 ENOG4105C6T cysteine synthase BF90_5285 ENOG4105C8J )-transporter BF90_5287 ENOG4105X5K response regulator receiver protein BF90_5288 ENOG4105H67 Protein of unknown function (DUF421) BF90_529 ENOG4108NRW Phospholipase, patatin family BF90_5291 ENOG4106KE4 Dehydrogenase BF90_5295 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF90_5296 ENOG4105CHR reductase BF90_5297 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF90_5298 ENOG4105C7K acetolactate synthase BF90_5299 ENOG4108ZP8 Acetolactate synthase small subunit BF90_530 ENOG4105KWG Pfam:DUF1696 BF90_5300 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF90_5302 ENOG4105C7B Threonine dehydratase BF90_5304 ENOG4105PNM synthesis protein BF90_5310 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BF90_5312 ENOG4105DY9 regulatoR BF90_5313 ENOG4105CYC Transferase BF90_5317 ENOG4105F6J Alpha beta hydrolase fold BF90_5324 ENOG41068WN BF90_5328 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BF90_5329 ENOG4105C72 UPF0176 protein BF90_5331 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BF90_5333 ENOG4105C0X amino acid BF90_5334 ENOG4105C0X amino acid BF90_5339 ENOG4107RHR regulatoR BF90_5341 ENOG4105D9N nucleoside BF90_5342 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BF90_5348 ENOG4107RAQ aminopeptidase BF90_5349 ENOG4107STQ Multicopper oxidase BF90_5359 ENOG4108T5E Copper resistance protein BF90_5360 ENOG4105KTB nuclear export factor GLE1 BF90_5362 ENOG4107RT3 EamA-like transporter family BF90_5363 ENOG4105GZI Transcriptional regulator BF90_5364 ENOG4108Z40 Transcriptional regulator BF90_5365 ENOG4107ZXU DSBA oxidoreductase BF90_5366 ENOG4108TVJ Nitroreductase BF90_5368 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF90_5369 ENOG4106F5Q Membrane BF90_537 ENOG4105PKS Excinuclease abc c subunit domain protein BF90_5370 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF90_5372 ENOG4105CKI cobalamin synthesis protein BF90_5376 ENOG4108Z7G MaoC domain protein dehydratase BF90_5377 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF90_5379 ENOG4105C0Z ABC transporter BF90_5380 ENOG4108IV0 ABC, transporter BF90_5381 ENOG4105C32 Amino acid ABC transporter (Permease) BF90_5383 ENOG4105SKE transcriptional Regulator LysR family BF90_5387 ENOG4105YGB Transcriptional regulator BF90_5389 ENOG4105C4M (Ubiquinol oxidase) subunit I BF90_5390 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF90_5391 ENOG4108JJ9 ABC, transporter BF90_5392 ENOG4108JJ8 (ABC) transporter BF90_5400 ENOG4105BZ1 (ABC) transporter BF90_5401 ENOG4105BZ1 (ABC) transporter BF90_5402 ENOG4105EFI regulatoR BF90_5404 ENOG4105BZU Histidine kinase BF90_5407 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BF90_5408 ENOG4108ZJ4 polysaccharide deacetylase BF90_5412 ENOG4105D6E homoserine dehydrogenase BF90_5417 ENOG4108KGH TRANSCRIPTIONal BF90_5419 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF90_5420 ENOG4105BZU Histidine kinase BF90_5421 ENOG4107VMI polysaccharide deacetylase BF90_5423 ENOG4105KT7 mgtC SapB transporter BF90_5424 ENOG4105VRR gCN5-related N-acetyltransferase BF90_5426 ENOG4105DUU IucA IucC family protein BF90_5427 ENOG4105CEY Amp-dependent synthetase and ligase BF90_5430 ENOG4108WBH protein TIM barrel BF90_5431 ENOG4105YWU small acid-soluble spore protein BF90_5433 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF90_5443 ENOG4105KRN Transcriptional regulator, abrb family BF90_5445 ENOG4105YVS arsR family transcriptional regulator BF90_5446 ENOG4107SET aldo keto reductase BF90_5447 ENOG4107XZQ multidrug resistance protein BF90_545 ENOG4107VFR oxidoreductase BF90_5453 ENOG4105C8Q Methyl-accepting chemotaxis BF90_5456 ENOG4108K88 Membrane BF90_5457 ENOG4108WPJ Ferritin-like domain BF90_5460 ENOG4105DEN Luciferase family BF90_5464 ENOG4107QM2 Aldo Keto reductase BF90_5465 ENOG4105CKI cobalamin synthesis protein BF90_5476 ENOG4105DSE periplasmic solute binding protein BF90_5478 ENOG4105K4T epimerase BF90_5480 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF90_5485 ENOG4105CVJ phosphoglycerate mutase BF90_5489 ENOG4107T5V SNARE associated Golgi BF90_5492 ENOG4108PJD permease BF90_5494 ENOG4108S4H thioesterase Superfamily protein BF90_5495 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF90_5499 ENOG4105SXS Protein of unknown function (DUF456) BF90_550 ENOG4105PAD Hydrolase BF90_5500 ENOG4105C37 (CBS) domain BF90_5505 ENOG4108Z7R Chaperone CsaA BF90_5509 ENOG4108ZRV stage ii sporulation protein p BF90_5511 ENOG4108VXD carboxy-peptidase BF90_5513 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF90_5518 ENOG4108X4Q Hydrolase BF90_5520 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF90_5521 ENOG4107RBS Methyltransferase BF90_5524 ENOG41087PP glycosyltransferase MGT family BF90_5525 ENOG4108JYZ YitT family BF90_5526 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF90_5532 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF90_554 ENOG4105DY8 decarboxylase BF90_5541 ENOG4105KBJ sporulation protein ytfj BF90_5546 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF90_5550 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BF90_5551 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BF90_5553 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BF90_5559 ENOG4108V06 Glutathione peroxidase BF90_5562 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF90_5566 ENOG4108IUE nitrate reductase beta subunit BF90_5567 ENOG4105R3A Nitrate reductase BF90_5572 ENOG4107V6Q Cyclic nucleotide-binding domain BF90_5573 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF90_5574 ENOG4105D06 uba thif-type nad fad binding protein BF90_5575 ENOG4105D06 uba thif-type nad fad binding protein BF90_5576 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF90_5577 ENOG4108ZAF Molybdopterin BF90_558 ENOG4108IUM Glycogen debranching enzyme BF90_5582 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF90_5583 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF90_5584 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF90_5585 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BF90_5586 ENOG4108IFG nitrite reductase, (NAD(P)H) BF90_5587 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF90_5595 ENOG4105EKQ RNA-directed DNA polymerase BF90_5617 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF90_5624 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) BF90_5626 ENOG4108MEK Metal-binding protein YodA BF90_5629 ENOG4105DQ6 Transposase BF90_563 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF90_5632 ENOG4105DQ6 Transposase BF90_5634 ENOG4108IBT Inherit from COG: transposase BF90_5641 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF90_5643 ENOG4105KRN Transcriptional regulator, abrb family BF90_565 ENOG4105FDR Membrane BF90_5667 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF90_5673 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BF90_5683 ENOG4105DQ6 Transposase BF90_5684 ENOG4105DQ6 Transposase BF90_5688 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF90_5689 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF90_5693 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF90_5694 ENOG4106AKK s-layer domain-containing protein BF90_57 ENOG4105BZW Glycerate kinase BF90_5700 ENOG4105DHF Membrane BF90_572 ENOG4108V3A UPF0421 protein BF90_5749 ENOG4105CNU cell division protein FtsK BF90_576 ENOG4105MSI germination protein ypeb BF90_5762 ENOG4106JUT Streptomycin 3''-adenylyltransferase BF90_5774 ENOG4105EKQ RNA-directed DNA polymerase BF90_5795 ENOG4105K4H Nlp p60 protein BF90_58 ENOG4107QPK )-transporter BF90_580 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BF90_581 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BF90_5810 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF90_5811 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF90_582 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BF90_5821 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF90_5825 ENOG4108J59 Extracellular solute-binding protein, family 5 BF90_583 ENOG4107Z3H Transcriptional regulator, TetR family BF90_5830 ENOG4105N14 lysine exporter protein LysE YggA BF90_5838 ENOG4105C3F Signal peptidase i BF90_5856 ENOG4105EWC Purine nucleoside phosphorylase BF90_5862 ENOG4105DQ6 Transposase BF90_5866 ENOG4107QJE Chromosome Partitioning Protein BF90_589 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BF90_59 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF90_593 ENOG4105E98 transcriptional regulator DeoR family BF90_597 ENOG41062ES Transcriptional regulator BF90_60 ENOG41062D9 Histidine kinase BF90_602 ENOG4107QKR Dehydrogenase BF90_604 ENOG4107RUY (E1 component), alpha subunit BF90_606 ENOG4105E1F short-chain dehydrogenase reductase BF90_607 ENOG4105RHY Pfam:UPF0157 BF90_612 ENOG4107SQ8 Glycine betaine BF90_613 ENOG4108IJ7 Glycine betaine BF90_618 ENOG4105E66 phosphoriboisomerase A BF90_619 ENOG41082BV acetyltransferase BF90_620 ENOG4108M1A Chitin-binding protein BF90_629 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF90_63 ENOG4105C8J )-transporter BF90_635 ENOG4108Z7F N-acetyltransferase BF90_639 ENOG4105EEM helicase BF90_643 ENOG4105C9U ATP-dependent DNA helicase RecQ BF90_652 ENOG4108M1A Chitin-binding protein BF90_655 ENOG4105BZG amino acid carrier protein BF90_656 ENOG4105C26 Dehydrogenase BF90_657 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF90_658 ENOG4105CTU Proline racemase BF90_659 ENOG4105CTU Proline racemase BF90_660 ENOG41080HI glycine oxidase BF90_667 ENOG4107T5V SNARE associated Golgi BF90_67 ENOG4107XGZ Hydrolase BF90_670 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF90_671 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BF90_674 ENOG4105DTQ mandelate racemase muconate lactonizing BF90_68 ENOG4105CY2 Citrate transporter BF90_682 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BF90_683 ENOG4105BZU Histidine kinase BF90_684 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF90_69 ENOG4105C0A alcohol dehydrogenase BF90_691 ENOG4105DPN Oligoendopeptidase f BF90_694 ENOG4105EPR degv family BF90_7 ENOG4105MCT stage V sporulation protein S BF90_702 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF90_703 ENOG4106K7D Major facilitator family transporter BF90_707 ENOG4107BMA Transglycosylase associated protein BF90_710 ENOG41089UC methyltransferase, type 11 BF90_716 ENOG4105CHM Aminotransferase BF90_72 ENOG4105KD7 acetyltransferase BF90_722 ENOG4105DVE abc transporter atp-binding protein BF90_731 ENOG4105C02 permease BF90_733 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BF90_734 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BF90_735 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BF90_736 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BF90_74 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BF90_742 ENOG4105E09 nadh pyrophosphatase BF90_746 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BF90_756 ENOG4107VC0 DNA alkylation repair enzyme BF90_758 ENOG4107VMI polysaccharide deacetylase BF90_760 ENOG4108ZCF integral membrane protein BF90_761 ENOG4105E0M Sulfatase BF90_762 ENOG4105C5H ABC transporter BF90_764 ENOG4105EYF MMPL domain protein BF90_765 ENOG4105EYF MMPL domain protein BF90_766 ENOG41082JN Transcriptional regulator BF90_770 ENOG4105CIH Imidazole acetol-phosphate transaminase BF90_771 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BF90_772 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF90_780 ENOG41069ER domain protein BF90_782 ENOG4105EMN RNA polymerase sigma factor BF90_788 ENOG4105D4B ABC, transporter BF90_79 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BF90_790 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BF90_792 ENOG4105DKT Transcriptional regulator BF90_793 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BF90_795 ENOG41061GT Aldolase BF90_799 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BF90_805 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BF90_806 ENOG4105II7 pyrroline-5-carboxylate reductase BF90_808 ENOG4107258 Transcriptional regulator BF90_810 ENOG4105E0Y RtcB Protein BF90_811 ENOG4105ECK Fatty Acid Desaturase BF90_812 ENOG4105G6Z alkaline phosphatase BF90_814 ENOG4105VMP Transcriptional regulator BF90_817 ENOG41090T1 Membrane BF90_819 ENOG4108WCX response regulator BF90_821 ENOG41068WN BF90_826 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF90_83 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BF90_831 ENOG4105CKK Glycosyl transferase, family 2 BF90_836 ENOG4105CKK Glycosyl transferase, family 2 BF90_838 ENOG4105C8Y Acetylornithine aminotransferase BF90_847 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF90_849 ENOG4108TVJ Nitroreductase BF90_850 ENOG4105FS7 Transcriptional regulator BF90_857 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF90_859 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF90_86 ENOG4107RVG penicillin-binding protein BF90_865 ENOG4108XET gCN5-related N-acetyltransferase BF90_87 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF90_88 ENOG4105E9Q Acyl-transferase BF90_881 ENOG410635A Membrane BF90_882 ENOG4105KNA -acetyltransferase BF90_883 ENOG4108IQI permease BF90_885 ENOG4105F1N DNA alkylation repair BF90_89 ENOG4108UT2 hemolysin iii BF90_893 ENOG4107RF6 penicillin-binding protein BF90_895 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BF90_904 ENOG4105P4J Allophanate hydrolase, subunit 1 BF90_905 ENOG4107258 Transcriptional regulator BF90_907 ENOG4106N3A copper homeostasis protein cutc BF90_908 ENOG4108ZRV stage ii sporulation protein p BF90_909 ENOG4108ZHR arsR family transcriptional regulator BF90_91 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BF90_911 ENOG4105FDT acyl-CoA dehydrogenase BF90_915 ENOG4105DWD nucleoside recognition domain protein BF90_921 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF90_93 ENOG4108RCR degv family BF90_936 ENOG4105E2A Dehydrogenase BF90_939 ENOG4108IJ0 Aspartate ammonia-lyase BF90_94 ENOG4105E8R UPF0173 metal-dependent hydrolase BF90_940 ENOG4105HDK L-asparaginase BF90_941 ENOG4108IMY Transcriptional regulator BF90_943 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF90_944 ENOG4105CUB amino acid BF90_946 ENOG4105II7 pyrroline-5-carboxylate reductase BF90_948 ENOG4105C6K Malic enzyme BF90_95 ENOG4108KF3 Electron transport protein SCO1 SenC BF90_950 ENOG4108NHD germination protein BF90_951 ENOG4108Q8B Spore germination protein BF90_956 ENOG4105CSV Glutaminase BF90_96 ENOG4107Y70 Heat shock protein BF90_964 ENOG4105CGH 5'-nucleotidase BF90_965 ENOG4105CH6 catalase BF90_967 ENOG4105CHJ isochorismatase hydrolase BF90_97 ENOG4105CAQ asparagine synthetase BF90_972 ENOG41090MY MarR family Transcriptional regulator BF90_979 ENOG4108606 TspO/MBR family BF90_980 ENOG4105CVP deoxyribo-dipyrimidine photolyase BF90_983 ENOG4108TWJ NADH dehydrogenase subunit 5 BF90_984 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BF90_986 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF90_987 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BF90_988 ENOG4105DSE periplasmic solute binding protein BF90_989 ENOG4105CC5 ABC transporter BF90_990 ENOG4105DIK (ABC) transporter BF90_996 ENOG4105D6J arsenicaL-resistance protein BF90_997 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BF90_998 ENOG41085FC arsR family transcriptional regulator