locus-tag class description BF31_1 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF31_100 ENOG4107VRP DNA repair exonuclease BF31_1016 ENOG4108NMV polysaccharide deacetylase BF31_1019 ENOG4105D1F ATP-binding protein BF31_1024 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF31_1025 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF31_1026 ENOG4108JJB ABC transporter BF31_1032 ENOG41067V7 50S ribosomal protein L36 BF31_1034 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF31_1036 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF31_1041 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BF31_106 ENOG4105K8R UPF0145 protein BF31_1062 ENOG4105XPM ribosomal protein BF31_1063 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BF31_1065 ENOG4107Y49 methyltransferase BF31_1070 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BF31_1072 ENOG4105QIV RNA polymerase BF31_1073 ENOG4105M0M Tetracycline resistance protein BF31_1078 ENOG4105D7W serine acetyltransferase BF31_1082 ENOG4105CTP PilT protein domain protein BF31_1084 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BF31_1087 ENOG4108Z0C Uvrb UvrC protein BF31_1094 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BF31_1096 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BF31_1097 ENOG4105KRF dihydroneopterin aldolase BF31_1098 ENOG4105EEI dihydropteroate synthase BF31_1099 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BF31_11 ENOG4105ENX hydrolase BF31_1100 ENOG4105DDQ anthranilate synthase BF31_1101 ENOG4105CRQ synthase (Component I) BF31_1102 ENOG4105C6T cysteine synthase BF31_1105 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BF31_1106 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF31_1107 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BF31_111 ENOG4105BZU Histidine kinase BF31_1111 ENOG41060GV RNA binding s1 domain protein BF31_1114 ENOG4105VYY sporulation protein yabp BF31_1115 ENOG41082I2 s4 domain protein BF31_1116 ENOG4108IY2 MazG family BF31_1118 ENOG4108M14 stage v sporulation protein t BF31_1119 ENOG4108JA2 transcriptioN-repair coupling factor BF31_112 ENOG4105BZU Histidine kinase BF31_1121 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BF31_1122 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BF31_1125 ENOG4105KME endoribonuclease L-psp BF31_1126 ENOG4105DFT pur operon repressor BF31_1129 ENOG4105W42 Veg protein BF31_113 ENOG4108MJI response regulator BF31_1130 ENOG4105XFA sporulation peptidase YabG BF31_1132 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BF31_1133 ENOG4105F8V Hydrolase, tatD family BF31_1135 ENOG4105KRN Transcriptional regulator, abrb family BF31_1136 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BF31_1138 ENOG41060K3 Methyltransferase BF31_1140 ENOG4105MA4 psp1 domain protein BF31_1141 ENOG4105FA2 dna polymerase iii BF31_1143 ENOG4105CXN decarboxylase BF31_115 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF31_1151 ENOG41067KS pro-sigma K processing BF31_1155 ENOG4105C6E dna polymerase iii BF31_1156 ENOG4108Z6B deaminase BF31_1157 ENOG4105GTG Isochorismatase BF31_1159 ENOG4105ZMH deoxynucleoside kinase BF31_1166 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF31_117 ENOG4105WN5 stage II sporulation protein BF31_1175 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF31_1178 ENOG410848D S4 domain protein YaaA BF31_1179 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF31_1183 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF31_1185 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BF31_1189 ENOG4107QJE Chromosome Partitioning Protein BF31_1190 ENOG4105FA0 parb-like partition protein BF31_1191 ENOG4108ZDA Sporulation protein YyaC BF31_1192 ENOG4105D8X mechanosensitive ion channel BF31_1193 ENOG4105VDK protein, conserved in bacteria BF31_1194 ENOG4105C3G gtp-binding protein BF31_1196 ENOG4108UUM single-stranded DNA-binding protein BF31_1198 ENOG4108XMW Membrane BF31_1199 ENOG4105BZR domain protein BF31_1201 ENOG4105CDU Replicative dna helicase BF31_1207 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF31_1208 ENOG4105BZU Histidine kinase BF31_1211 ENOG4105Q2H domain protein BF31_1212 ENOG4105C0H protease BF31_1216 ENOG4105DPN Oligoendopeptidase f BF31_1219 ENOG4105C1J atp-dependent rna helicase BF31_1221 ENOG4108UT2 hemolysin iii BF31_1222 ENOG4105CMR udp-glucose 4-epimerase BF31_1224 ENOG4105IW1 AmiS UreI transporter BF31_1226 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF31_1229 ENOG4107RGD Major Facilitator superfamily BF31_1230 ENOG4108HRK Histidine kinase BF31_1231 ENOG4105DY9 regulatoR BF31_1234 ENOG4106F5Q Membrane BF31_1235 ENOG4105E0X reductase BF31_1237 ENOG41067SE Tetr family transcriptional regulator BF31_1238 ENOG4105CKK Glycosyl transferase, family 2 BF31_1243 ENOG4105C5H ABC transporter BF31_1244 ENOG4105JEU Glycosyl transferase, family 2 BF31_1246 ENOG4108S4H thioesterase Superfamily protein BF31_1248 ENOG4106YBV Methyl-accepting chemotaxis BF31_1249 ENOG4105EN6 Membrane BF31_1253 ENOG41079KZ Major Facilitator Superfamily BF31_1254 ENOG4105DY9 regulatoR BF31_1255 ENOG4105D22 carbon starvation protein BF31_1256 ENOG4105VCD cytoplasmic protein BF31_1257 ENOG4105BZU Histidine kinase BF31_1258 ENOG4105DWF phosphomethylpyrimidine kinase BF31_1259 ENOG4105BZU Histidine kinase BF31_1260 ENOG4105BZU Histidine kinase BF31_1261 ENOG4105WH1 Two component transcriptional regulator luxr family BF31_1263 ENOG4108Y4K DNA-binding transcriptional activator BF31_1268 ENOG4105D6E homoserine dehydrogenase BF31_1271 ENOG41090WU lipolytic protein G-D-S-L family BF31_1272 ENOG4105CJ1 ABC, transporter BF31_1273 ENOG4108TU7 Inherit from COG: (ABC) transporter BF31_1275 ENOG4105VCH membrane BF31_1276 ENOG410667J hydrolase BF31_1278 ENOG4107SVH Potassium channel protein BF31_1282 ENOG4108VKI Cell wall hydrolase BF31_1285 ENOG4108IJ2 phosphate acetyltransferase BF31_1288 ENOG4108VCI transcription factor, rsfa family BF31_1290 ENOG4105DQ5 transport system permease protein BF31_1291 ENOG4105DQ5 transport system permease protein BF31_1292 ENOG4105EHG Permease protein BF31_1293 ENOG4105E0A ABC, transporter BF31_1294 ENOG4108MES Periplasmic binding protein BF31_1295 ENOG4105DCI Phosphohydrolase BF31_1296 ENOG41069HH 4-oxalocrotonate tautomerase BF31_1297 ENOG4108Z4T Peptidase M50 BF31_1298 ENOG4108XFG YwhD family BF31_1299 ENOG4105BZ4 penicillin-binding protein BF31_130 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BF31_1300 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF31_1301 ENOG4107SWG transcriptional regulator MERR family BF31_1302 ENOG4105DXB Major Facilitator superfamily BF31_1304 ENOG4105CYW agmatinase BF31_1308 ENOG410684U Domain of unknown function (DUF1934) BF31_1310 ENOG4105EMN RNA polymerase sigma factor BF31_1314 ENOG4105IIU Aminopeptidase BF31_1318 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BF31_1319 ENOG4108M15 ABC transporter BF31_1320 ENOG4105KCT ABC transporter BF31_1321 ENOG4105BZU Histidine kinase BF31_1326 ENOG4105BZU Histidine kinase BF31_1329 ENOG4105DF6 Fe-S oxidoreductase BF31_1331 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF31_1332 ENOG4105C1G acyl-Coa dehydrogenase BF31_1333 ENOG4105C1G acyl-Coa dehydrogenase BF31_1340 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BF31_1341 ENOG4105CBT Fructose-1,6-bisphosphatase BF31_1342 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BF31_1345 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BF31_1346 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF31_1347 ENOG4108ZXQ stage ii sporulation protein r BF31_1349 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF31_1352 ENOG4107XC4 flavin reductase domain protein, FMN-binding BF31_1353 ENOG4108VGI doxx family BF31_1356 ENOG4108YZG isomerase BF31_136 ENOG410847I Transcriptional regulator, BadM Rrf2 family BF31_1361 ENOG41062M3 atp synthase BF31_1362 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BF31_137 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF31_1372 ENOG4105BZU Histidine kinase BF31_1373 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF31_1375 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF31_1376 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF31_138 ENOG4105CMT Dihydroxyacetone kinase BF31_1381 ENOG4105D65 subunit l BF31_1382 ENOG4105C8S subunit m BF31_1383 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF31_1384 ENOG4106778 Protein of unknown function (DUF1146) BF31_1388 ENOG4108IUW ABC transporter BF31_1389 ENOG4105DY9 regulatoR BF31_1392 ENOG4105FRN stage II sporulation protein BF31_1394 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BF31_140 ENOG4105CMT Dihydroxyacetone kinase BF31_1404 ENOG4105EY8 ABC transporter BF31_1405 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF31_1406 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF31_1407 ENOG4105ESV Glycosyl transferase, family 4 BF31_1409 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BF31_1412 ENOG410901P UPF0249 protein BF31_1413 ENOG4105F8D glycoside hydrolase family 4 BF31_1414 ENOG4105VCP PTS System BF31_1415 ENOG4105CK1 PTS System BF31_1417 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BF31_1418 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF31_1419 ENOG4105VCP PTS System BF31_1421 ENOG4105VZJ PTS System BF31_1424 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BF31_1425 ENOG4105ECB domain protein BF31_1426 ENOG4107RSM transcriptional regulator BF31_1434 ENOG4105DAA L-lactate BF31_1436 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BF31_1438 ENOG4105E0M Sulfatase BF31_144 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF31_1444 ENOG4107R8N Glycosyl transferase, family 2 BF31_1446 ENOG4105C94 Transporter BF31_1447 ENOG41069ER domain protein BF31_1452 ENOG4105KBK Zinc finger, swim domain protein BF31_1453 ENOG4105C0D helicase BF31_1459 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF31_1461 ENOG4107RBB ABC transporter, permease BF31_1462 ENOG4105C19 ABC transporter BF31_1466 ENOG4105CXY transporter BF31_1469 ENOG4105BZU Histidine kinase BF31_1470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF31_1471 ENOG4105CMR udp-glucose 4-epimerase BF31_1474 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF31_1475 ENOG4108KGH TRANSCRIPTIONal BF31_1476 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BF31_1478 ENOG4105KVH Transcriptional regulator BF31_148 ENOG4108IG5 Transcriptional regulator BF31_1481 ENOG41081UC Inherit from COG: Competence protein BF31_1482 ENOG4105VEQ Cold shock protein BF31_1483 ENOG4105MS2 ribosomal subunit Interface protein BF31_1484 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BF31_1485 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BF31_1487 ENOG4105CAK Cell division ATP-binding protein ftsE BF31_1488 ENOG4105CRP Part of the ABC transporter FtsEX involved in BF31_1489 ENOG4105CN1 protease BF31_149 ENOG4107P5I polyketide synthase BF31_1491 ENOG4105BZ1 (ABC) transporter BF31_1494 ENOG4108WS4 fmn reductase BF31_1496 ENOG4105DUM transcriptional regulator, lysR family BF31_1497 ENOG4105HMI Membrane BF31_1501 ENOG4107TXC Transcriptional regulator BF31_1504 ENOG4105D7V transposase BF31_1505 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BF31_1506 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF31_1508 ENOG41086DT Membrane protein of unknown function BF31_1512 ENOG4108S4C acetyltransferase BF31_1514 ENOG4105C3M thioredoxin reductase BF31_1516 ENOG4108Z4K mutator MutT protein BF31_1518 ENOG4105CHW UPF0052 protein BF31_1520 ENOG4105KRI phosphocarrier protein (HPr BF31_1521 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF31_1522 ENOG4105H67 Protein of unknown function (DUF421) BF31_1525 ENOG4105CZ3 stage V sporulation protein ad BF31_1526 ENOG41090VF Stage v sporulation protein ac BF31_1530 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF31_1535 ENOG4105CP7 Triose-phosphate isomerase BF31_1536 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BF31_1538 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF31_1543 ENOG4105EFC phage portal protein HK97 family BF31_1562 ENOG41067MG lrgb family BF31_1563 ENOG4105XZU Preprotein translocase, subunit SecG BF31_1565 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BF31_1570 ENOG4105CM4 permease protein BF31_1571 ENOG4108IPW abc transporter atp-binding protein BF31_1574 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BF31_1575 ENOG4108MK9 spermidine N(1)-acetyltransferase BF31_1578 ENOG4105WMR Protein CrcB homolog BF31_1579 ENOG4105WMR Protein CrcB homolog BF31_1581 ENOG4105C8Q Methyl-accepting chemotaxis BF31_1583 ENOG4105D4A Cell wall formation (By similarity) BF31_1584 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF31_1587 ENOG4105KVH Transcriptional regulator BF31_1588 ENOG4105F27 Major Facilitator BF31_1589 ENOG4105CV8 reductase BF31_159 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF31_1594 ENOG4108RYK Nad-dependent epimerase dehydratase BF31_1597 ENOG4105D9N nucleoside BF31_1598 ENOG4105D9N nucleoside BF31_16 ENOG4105CNA YD repeat protein BF31_1603 ENOG4108URH decarboxylase BF31_1606 ENOG4108RMU ferritin dps family protein BF31_1608 ENOG4105NCW Trka-c domain protein BF31_1609 ENOG4107S91 Sodium hydrogen exchanger BF31_1613 ENOG4105D4Y metalloprotease BF31_1614 ENOG4105VG1 fes assembly suf system protein BF31_1617 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BF31_1619 ENOG4105BZU Histidine kinase BF31_1620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF31_1621 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF31_1623 ENOG4107ZTW SNARE associated Golgi BF31_1630 ENOG4107AYK membrAne BF31_1632 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF31_1634 ENOG4107R7I amino acid BF31_1635 ENOG4108SUT Major Facilitator Superfamily BF31_1639 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF31_1643 ENOG4105DZ1 carboxypeptidase BF31_1646 ENOG4105CHU acetyl-coa acetyltransferase BF31_1647 ENOG4105C1G acyl-Coa dehydrogenase BF31_1648 ENOG4108W8B Beta-lactamase domain protein BF31_1654 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF31_1663 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF31_1669 ENOG4108UMI ABC transporter, permease BF31_167 ENOG4105CDU Replicative dna helicase BF31_1670 ENOG4105D01 (LipO)protein BF31_1671 ENOG4105D01 (LipO)protein BF31_1672 ENOG4105C3K feS assembly ATPase SufC BF31_1673 ENOG4105JRK feS assembly protein SufD BF31_1674 ENOG4105C9B Cysteine desulfurase BF31_1675 ENOG4108UNV SUF system FeS assembly protein, NifU family BF31_1676 ENOG4105DIW FeS assembly protein SUFB BF31_1679 ENOG4107R8B 5'-nucleotidase BF31_1680 ENOG4105KZD Domain of unknown function (DUF1805) BF31_1682 ENOG4105FAA peptidase M23 BF31_1687 ENOG41090T1 Membrane BF31_1688 ENOG4107TXC Transcriptional regulator BF31_1689 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BF31_1690 ENOG4105MMD transcriptional regulator BF31_1693 ENOG4105CBT Fructose-1,6-bisphosphatase BF31_1696 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF31_1697 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF31_1699 ENOG4108W5N phosphatidylglycerophosphatase a BF31_1702 ENOG41083MR nifu domain-containing protein BF31_1711 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BF31_1712 ENOG4105C4B ABC transporter, permease BF31_1713 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF31_1717 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BF31_1720 ENOG4105EWC Purine nucleoside phosphorylase BF31_1726 ENOG4105CEP NADH dehydrogenase BF31_1729 ENOG41069ER domain protein BF31_1733 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF31_1737 ENOG4105KA0 thioesterase Superfamily protein BF31_1738 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BF31_1741 ENOG4107R3E Citrate transporter BF31_1743 ENOG4105Y38 Kinase-associated protein B BF31_1746 ENOG4105C87 Aminotransferase class I and II BF31_1748 ENOG4108MUZ hydrolase BF31_1749 ENOG4105C5I Dehydrogenase BF31_1750 ENOG4108ZB6 transcriptional regulator AsnC family BF31_1751 ENOG4105CHM Aminotransferase BF31_1753 ENOG4105WG9 Conserved Protein BF31_1754 ENOG4107QYV phosphohexose isomerase BF31_1755 ENOG4107PBV potassium channel BF31_1757 ENOG4105KT7 mgtC SapB transporter BF31_176 ENOG4108MRH transcriptional regulatory protein BF31_1765 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BF31_178 ENOG4105CSH Transporter BF31_1784 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF31_1786 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BF31_1788 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BF31_1793 ENOG4105VEQ Cold shock protein BF31_1795 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF31_1796 ENOG4105E4F Isochorismate synthase BF31_1797 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BF31_1798 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BF31_1799 ENOG4108IPT Naphthoate synthase BF31_1801 ENOG4105DTQ mandelate racemase muconate lactonizing BF31_1807 ENOG41069H0 dihydroorotase EC 3.5.2.3 BF31_1811 ENOG4105FDP GntR family transcriptional regulator BF31_1812 ENOG4105C6Z Gluconate BF31_1822 ENOG41086D8 Transcriptional regulator BF31_1823 ENOG4105C19 ABC transporter BF31_1826 ENOG4107ZTW SNARE associated Golgi BF31_1833 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BF31_1834 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF31_1839 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF31_184 ENOG4108JQ7 (ABC) transporter BF31_1840 ENOG4105BZU Histidine kinase BF31_1847 ENOG41087YS Phage shock protein A BF31_1856 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF31_1857 ENOG4105C4M (Ubiquinol oxidase) subunit I BF31_1859 ENOG4108V2W Carbonate dehydratase BF31_1866 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF31_187 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF31_1870 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BF31_1872 ENOG4105D2X ABC transporter substrate-binding protein BF31_1876 ENOG4107T7U Sulfatase BF31_1877 ENOG4107S9D Alpha beta hydrolase BF31_1878 ENOG4105BZU Histidine kinase BF31_1879 ENOG4105BZU Histidine kinase BF31_1880 ENOG4105EGD dinuclear metal center protein, YbgI family BF31_1890 ENOG4108RIR Molybdenum cofactor biosynthesis protein BF31_1892 ENOG4105BZF Glycosyl transferase (Group 1 BF31_1893 ENOG4105YVM Phosphoesterase, PA-phosphatase related BF31_1894 ENOG4108Z0R Transferase BF31_1895 ENOG4105E8V Alpha Beta Hydrolase Fold protein BF31_1901 ENOG4105DA5 (ABC) transporter BF31_1903 ENOG4105N5T Radical SAM Protein BF31_1907 ENOG4105C19 ABC transporter BF31_1910 ENOG4105NCW Trka-c domain protein BF31_1911 ENOG4107S91 Sodium hydrogen exchanger BF31_1912 ENOG410605W Major Facilitator BF31_1918 ENOG4108B31 Spore germination protein BF31_1920 ENOG4105DWV Homoserine O-trans-acetylase BF31_1922 ENOG41085GJ domain protein BF31_1926 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF31_1927 ENOG4105D06 uba thif-type nad fad binding protein BF31_1929 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF31_1930 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BF31_1931 ENOG4108ZAF Molybdopterin BF31_1934 ENOG4105CSC Glucose uptake protein BF31_1935 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BF31_1936 ENOG4108VJ1 Transcriptional regulator (CarD family BF31_1943 ENOG4105CBX hi0933 family BF31_1946 ENOG4105YW5 deoR family transcriptional regulator BF31_1947 ENOG4107QSE Dipeptidase BF31_1948 ENOG4107QSE Dipeptidase BF31_195 ENOG4105CTU Proline racemase BF31_1950 ENOG4108IUM Glycogen debranching enzyme BF31_1951 ENOG4108V15 phosphotransferase enzyme family BF31_1954 ENOG4105C8F Beta-lactamase domain protein BF31_1960 ENOG4108VDD TRNA binding domain protein BF31_1969 ENOG4105C88 aminopeptidase BF31_1973 ENOG4105ETE Transcriptional regulator (LacI family BF31_1979 ENOG4105EP9 oxidoreductase BF31_1980 ENOG4107SNB ankyrin repeat protein YahD BF31_1982 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF31_1984 ENOG4105DGU Histone deacetylase BF31_1985 ENOG4105W87 Cbs domain BF31_1986 ENOG4105F1V Acetoin utilization protein BF31_1989 ENOG4105EMN RNA polymerase sigma factor BF31_199 ENOG4105DER m42 family BF31_1991 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF31_1995 ENOG4105C28 cystathionine BF31_1997 ENOG4105U5Y Transcriptional regulator BF31_1998 ENOG4105U5Y Transcriptional regulator BF31_2000 ENOG4106KR7 LysR family Transcriptional regulator BF31_2005 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF31_2007 ENOG4105EFZ amidohydrolase BF31_2010 ENOG4105KBJ sporulation protein ytfj BF31_2011 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BF31_2013 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BF31_2017 ENOG4108JYZ YitT family BF31_202 ENOG4105CGU Enoyl-CoA hydratase BF31_2026 ENOG4107YZX Universal stress protein BF31_2030 ENOG4105VZ8 Transcriptional regulator BF31_2032 ENOG41082W1 Cupin 2, conserved barrel domain protein BF31_2033 ENOG4105Z7P Acetyltransferase (GNAT) family BF31_2040 ENOG4105DC7 peptidase M24 BF31_2047 ENOG4105SFS phosphoesterase RecJ domain protein BF31_2049 ENOG4105VV2 BF31_205 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF31_2050 ENOG4105C0B DNA polymerase III (alpha subunit) BF31_2051 ENOG4105C6K Malic enzyme BF31_2052 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF31_2057 ENOG4105FS0 cytoplasmic membrane protein BF31_2058 ENOG4108REF Sporulation integral membrane protein ytvi BF31_206 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF31_2060 ENOG4105BZN citrate synthase BF31_2061 ENOG4108HMX isocitrate dehydrogenase (NADP) BF31_2065 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF31_2066 ENOG4105BZU Histidine kinase BF31_2067 ENOG4105C2M dna polymerase I BF31_2068 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BF31_2070 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BF31_2071 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BF31_2072 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF31_2076 ENOG4108TDW sporulation protein YtxC BF31_2077 ENOG4105C22 threonyL-tRNA synthetase BF31_2078 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BF31_208 ENOG4106AKK s-layer domain-containing protein BF31_2082 ENOG4105CN9 Peptidase m42 family protein BF31_2083 ENOG4108JGH Tetr family transcriptional regulator BF31_2084 ENOG4105CW7 secretion protein, HlyD family BF31_2085 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF31_2092 ENOG4108RWN rrna methyltransferase BF31_2094 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BF31_2095 ENOG4105C5S asparaginyl-tRNA synthetase BF31_2102 ENOG4105DCG PHP domain protein BF31_2105 ENOG4105FE9 pseudouridine synthase BF31_2107 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BF31_2109 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BF31_2112 ENOG4105E0A ABC, transporter BF31_2113 ENOG4105KFN sortase, SrtB family BF31_2116 ENOG4105DR4 Methyltransferase BF31_2119 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF31_2128 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF31_2129 ENOG4105J76 Periplasmic binding protein BF31_2131 ENOG4105CEY Amp-dependent synthetase and ligase BF31_2132 ENOG4107Z3H Transcriptional regulator, TetR family BF31_2133 ENOG41060WC Enoyl-CoA hydratase BF31_2134 ENOG4105BZJ Electron transfer flavoprotein BF31_2135 ENOG4105C10 Electron transfer flavoprotein BF31_2136 ENOG4105K63 Thioredoxin BF31_2139 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BF31_2141 ENOG4105E33 succinate dehydrogenase BF31_2143 ENOG4108VXD carboxy-peptidase BF31_2144 ENOG4105E14 MotA TolQ exbB proton channel BF31_2145 ENOG4105ER2 Ompa motb domain protein BF31_2146 ENOG4105ER2 Ompa motb domain protein BF31_2147 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BF31_2148 ENOG4108IUX (ABC) transporter BF31_2149 ENOG4105RHA ABC transporter, permease BF31_2150 ENOG4108Z40 Transcriptional regulator BF31_2151 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BF31_2153 ENOG4108JCI Transcriptional regulator BF31_2154 ENOG41067S9 phage shock protein C, PspC BF31_2157 ENOG4105DY9 regulatoR BF31_2158 ENOG4108HRK Histidine kinase BF31_2159 ENOG4108JQ7 (ABC) transporter BF31_216 ENOG4105CHH sulfate transporter BF31_2162 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF31_2163 ENOG4105DEF Extracellular solute-binding protein, family 5 BF31_2164 ENOG4105DZC cytosine deaminase BF31_2165 ENOG4105DZC cytosine deaminase BF31_2168 ENOG4105PFC Transcriptional regulator BF31_2171 ENOG4105KBX Transcriptional regulator, TetR family BF31_2173 ENOG4108PCX Major Facilitator BF31_2175 ENOG4108XJQ germination protein BF31_2177 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BF31_2178 ENOG4105M59 Phosphodiesterase, mj0936 family BF31_2182 ENOG4108QCI YvbH-like oligomerisation region BF31_2188 ENOG4108IUQ atp-dependent protease BF31_219 ENOG4105D4P Coproporphyrinogen iii oxidase BF31_2192 ENOG4105K56 Transcriptional regulator BF31_2197 ENOG4105D52 delta-aminolevulinic acid dehydratase BF31_2199 ENOG41068KH stage VI sporulation protein D BF31_22 ENOG4105CEY Amp-dependent synthetase and ligase BF31_2201 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BF31_2202 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BF31_2206 ENOG4105DFF Rod shape-determining protein mreb BF31_2207 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BF31_221 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF31_2210 ENOG4107QMS site-determining protein BF31_2213 ENOG4105C03 ribonuclease BF31_2215 ENOG4105X36 (ribosomal) protein BF31_2218 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BF31_2221 ENOG4105EWM Histidine kinase BF31_2226 ENOG4105CQC Prephenate dehydratase BF31_2227 ENOG4108RPX mosc domain containing protein BF31_2230 ENOG4108IYU L-aspartate oxidase BF31_2231 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BF31_2236 ENOG41082BM Transcriptional regulator, arsr family BF31_2237 ENOG4108IPJ Membrane BF31_2238 ENOG4108IPJ Membrane BF31_2240 ENOG4108HUF Transporter BF31_2243 ENOG41061AI Protein of unknown function (DUF2905) BF31_2246 ENOG4105VIE preprotein translocase, subunit YajC BF31_2248 ENOG4108QG2 Membrane BF31_2249 ENOG4105CKP Polysaccharide Biosynthesis Protein BF31_2251 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BF31_2252 ENOG41076HS cation diffusion facilitator family transporter BF31_2253 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF31_2255 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF31_2258 ENOG4105CUT histidyl-tRNA synthetase BF31_226 ENOG4107FQX Alpha-acetolactate decarboxylase BF31_2260 ENOG4105CUZ uba thif-type nad fad binding protein BF31_2261 ENOG4105D1H recombination factor protein RarA BF31_2263 ENOG4105C3J Cysteine desulfurase BF31_2264 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BF31_2266 ENOG4105C7H Helicase, RecD TraA family BF31_2267 ENOG41060CR BF31_2270 ENOG4105C02 permease BF31_2272 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF31_2276 ENOG4105HHA aminodeoxychorismate lyase BF31_2277 ENOG4108VQJ O-methyltransferase BF31_2278 ENOG4105XYU peptidase (U32 family) BF31_2279 ENOG4105CFP Peptidase U32 BF31_2282 ENOG4107XRG penicillin-binding protein BF31_2288 ENOG4105C28 cystathionine BF31_2289 ENOG4108EKI Dehydrogenase BF31_2291 ENOG4108V5C ABC transporter BF31_2292 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF31_2300 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF31_2301 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF31_2303 ENOG4105MIR Phenylalanine 4-monooxygenase BF31_2304 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF31_2311 ENOG4108MUZ hydrolase BF31_2313 ENOG4105G6Z alkaline phosphatase BF31_2316 ENOG4108TVJ Nitroreductase BF31_2321 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF31_2324 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF31_2325 ENOG4105CQW ribosome biogenesis GTPase YqeH BF31_2327 ENOG410812S Rna-binding protein BF31_2329 ENOG4108WF2 Metal Dependent Phosphohydrolase BF31_233 ENOG410839P BF31_2331 ENOG4105DXX methyltransferase BF31_2333 ENOG4105KQC Competence protein BF31_2334 ENOG4108UK2 deaminase BF31_2335 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF31_2337 ENOG4105TQK DNA polymerase iii, delta' subunit BF31_2342 ENOG4105KVH Transcriptional regulator BF31_2343 ENOG4105CSA Coproporphyrinogen iii oxidase BF31_2345 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BF31_2349 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BF31_2350 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF31_2352 ENOG4105KTH gatB Yqey BF31_2353 ENOG41068P3 sporulation protein YqfC BF31_2355 ENOG4105C9A Phoh family BF31_2356 ENOG4105CTJ Metal Dependent Phosphohydrolase BF31_2358 ENOG4107YR5 Diacylglycerol kinase BF31_2359 ENOG4105KG3 cytidine deaminase BF31_236 ENOG4105CDA abc transporter atp-binding protein BF31_2360 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BF31_2365 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BF31_2366 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF31_2369 ENOG4105EGD dinuclear metal center protein, YbgI family BF31_237 ENOG4105DRP amino acid AbC transporter BF31_2374 ENOG41069ZM Protein of unknown function (DUF2624) BF31_2375 ENOG4108JYZ YitT family BF31_2376 ENOG4105FDK ABC transporter BF31_2378 ENOG4105N80 Ferric uptake regulator, Fur family BF31_2383 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF31_2385 ENOG4107RF6 penicillin-binding protein BF31_2386 ENOG4105PWN phosphate abc transporter BF31_2387 ENOG4105C8U phosphate abc transporter BF31_2388 ENOG4105E2Z phosphate ABC transporter (Permease BF31_2389 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BF31_239 ENOG4105BZ1 (ABC) transporter BF31_2390 ENOG4108UTW Plays a role in the regulation of phosphate uptake BF31_2394 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BF31_2396 ENOG4105DKQ ROK family BF31_2398 ENOG4105C5X domain protein BF31_24 ENOG4105DF9 Lipoate-protein, ligase BF31_240 ENOG4105BZ1 (ABC) transporter BF31_2402 ENOG4105C28 cystathionine BF31_2403 ENOG4105C28 cystathionine BF31_2405 ENOG4105C3R Methionine synthase BF31_2406 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF31_241 ENOG4105BZ1 (ABC) transporter BF31_242 ENOG4105C26 Dehydrogenase BF31_2430 ENOG4105C0D helicase BF31_2436 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF31_2437 ENOG4105CJ1 ABC, transporter BF31_244 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BF31_2444 ENOG41080TC multidrug resistance protein BF31_2448 ENOG4105WZW rhodanese family BF31_2449 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BF31_245 ENOG4105D5Q Arginine ornithine antiporter BF31_2454 ENOG4107YBY Hydrolase BF31_2455 ENOG4105CBJ Metal-dependent enzyme BF31_2458 ENOG4105DC7 peptidase M24 BF31_2463 ENOG4105CD2 stage iii sporulation protein aa BF31_2464 ENOG4105KR5 Stage iii sporulation protein BF31_2465 ENOG4108CQH stage III sporulation protein AC BF31_2466 ENOG4105KQ4 Stage iii sporulation protein ad BF31_2468 ENOG410644B Stage III sporulation protein af BF31_247 ENOG4105CH6 catalase BF31_2473 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF31_2474 ENOG4108ZSR alkaline shock protein BF31_2479 ENOG4105CTB Polyprenyl synthetase BF31_248 ENOG4107RKG DJ-1/PfpI family BF31_2481 ENOG4105DX0 Hemolysin A BF31_2483 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BF31_2484 ENOG4105S1Z Stage IV sporulation protein B BF31_2485 ENOG4107QQR Sporulation BF31_2488 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF31_2490 ENOG4108JUB Transcriptional regulator BF31_2492 ENOG4107RDP Dehydrogenase BF31_2496 ENOG4105CPP Dehydrogenase, E1 component BF31_2497 ENOG4105C7S Dehydrogenase BF31_2499 ENOG4105E09 nadh pyrophosphatase BF31_25 ENOG4108RQ5 Beta-lactamase domain-containing protein BF31_250 ENOG4105E5W Transporter BF31_2500 ENOG4105G7B Protein of unknown function (DUF2992) BF31_2502 ENOG4108HW3 (ABC) transporter BF31_2503 ENOG4105E5Q amino acid AbC transporter BF31_2504 ENOG4105CDA abc transporter atp-binding protein BF31_2505 ENOG4108QEG Membrane BF31_2506 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BF31_2508 ENOG4105D9U N-acetyltransferase BF31_2509 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF31_251 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF31_2511 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF31_2515 ENOG4105EJQ L-serine dehydratase BF31_2516 ENOG4105II7 pyrroline-5-carboxylate reductase BF31_2518 ENOG41069FQ Metallo-beta-lactamase superfamily BF31_2519 ENOG4108IXY short-chain dehydrogenase reductase BF31_252 ENOG4105NF4 modulator of drug activity BF31_2522 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BF31_2530 ENOG4105CGH 5'-nucleotidase BF31_2531 ENOG4105DFD Na H antiporter BF31_2533 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF31_2535 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BF31_2536 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF31_2537 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF31_2538 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BF31_2542 ENOG4108R6K riboflavin synthase, subunit alpha BF31_2543 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BF31_2547 ENOG4108YM7 Gcn5-related n-acetyltransferase BF31_2548 ENOG4105ETE Transcriptional regulator (LacI family BF31_2550 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF31_2554 ENOG4105RHY Pfam:UPF0157 BF31_2556 ENOG4105CPC Aldo Keto reductase BF31_2560 ENOG4105MZ9 stage II sporulation protein m BF31_2561 ENOG4105I3K Ferric uptake regulator, Fur family BF31_2563 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF31_2568 ENOG4105D7N magnesium and cobalt transport protein CorA BF31_257 ENOG4105KPY Small multidrug resistance protein BF31_2574 ENOG4105DVE abc transporter atp-binding protein BF31_2575 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF31_2576 ENOG4105DZ1 carboxypeptidase BF31_2577 ENOG41082AN stage II sporulation protein BF31_2579 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF31_258 ENOG4105KPY Small multidrug resistance protein BF31_2580 ENOG4105C8J )-transporter BF31_2584 ENOG41090VF Stage v sporulation protein ac BF31_2585 ENOG4105CZ3 stage V sporulation protein ad BF31_2587 ENOG4105G6R Stage v sporulation protein ae BF31_2589 ENOG4105J7I hydrolase BF31_2590 ENOG4105PTM secreted protein BF31_2591 ENOG4107ZE5 PPIases accelerate the folding of proteins BF31_2598 ENOG4105CE4 GlcNAc 6-P deacetylase BF31_26 ENOG4106AXD BF31_260 ENOG4108YXU transcriptional regulator AsnC family BF31_2600 ENOG4105FDP GntR family transcriptional regulator BF31_2602 ENOG4105CID antiterminator BF31_2605 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BF31_2609 ENOG4106TD9 Diguanylate cyclase BF31_261 ENOG4108PCN EamA-like transporter family BF31_2610 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF31_2611 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF31_2614 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BF31_2619 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BF31_2621 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BF31_2623 ENOG4105DTD Dehydrogenase BF31_2624 ENOG4105K7K Transcriptional regulator BF31_2631 ENOG4105CHU acetyl-coa acetyltransferase BF31_2640 ENOG4105CG3 alpha amylase, catalytic region BF31_2642 ENOG4107FKK extracellular solute-binding protein family 1 BF31_2644 ENOG4105EG2 ABC transporter, permease BF31_2645 ENOG4105FKQ transcriptional regulator BF31_2646 ENOG4105CHM Aminotransferase BF31_2648 ENOG4108HGU Histidine kinase BF31_2659 ENOG4105UIN BF31_2661 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF31_2664 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BF31_2665 ENOG4105EPM Diguanylate phosphodiesterase BF31_2668 ENOG4107IN1 Protein of unknown function (DUF1797) BF31_2670 ENOG4108XRC Protein of unknown function (DUF458) BF31_2677 ENOG4107ZYR domain protein BF31_2678 ENOG4105CN5 Metallo-Beta-Lactamase BF31_268 ENOG4106KNT transcriptional regulator BF31_2680 ENOG4108X4Q Hydrolase BF31_2681 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF31_2684 ENOG4105CPP Dehydrogenase, E1 component BF31_2685 ENOG4105C7S Dehydrogenase BF31_2694 ENOG4105CXN decarboxylase BF31_2698 ENOG4105ECY inositol monophosphatase BF31_270 ENOG4107RWR Sodium hydrogen exchanger BF31_2700 ENOG4105CI3 gtp-binding protein typa BF31_2701 ENOG4105QA2 BF31_2705 ENOG4108IAB Phoh family BF31_2708 ENOG4105CNI cell division protein FtsW BF31_2709 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BF31_271 ENOG4105CUB amino acid BF31_2719 ENOG4106UY4 Inherit from COG: Scp-like extracellular BF31_2722 ENOG4107TB6 phosphoglycerate mutase BF31_2727 ENOG4106H78 methyltransferase BF31_2728 ENOG4105H20 Sporulation integral membrane protein YlbJ BF31_2730 ENOG4105D78 K07001 NTE family protein BF31_2731 ENOG41063PX domain protein BF31_2733 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BF31_2741 ENOG4108IMY Transcriptional regulator BF31_2752 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF31_2755 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BF31_277 ENOG4107T5V SNARE associated Golgi BF31_2772 ENOG4105CAR Terminase, large subunit BF31_2774 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF31_2791 ENOG4105XSJ toxin secretion phage lysis holin BF31_2801 ENOG4105KNH Nucleic acid-binding protein BF31_2808 ENOG41068DC Essential cell division protein (By similarity) BF31_2809 ENOG4105CJN penicillin-binding protein BF31_2810 ENOG4105CJN penicillin-binding protein BF31_2811 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF31_2814 ENOG4105CNI cell division protein FtsW BF31_2815 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF31_2816 ENOG4105D4A Cell wall formation (By similarity) BF31_2817 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BF31_2818 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BF31_2819 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BF31_2821 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF31_2823 ENOG4105WR5 sporulation protein, YlmC YmxH family BF31_2824 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BF31_2825 ENOG4105DFA alanine racemase domain protein BF31_2827 ENOG41067XK integral membrane protein BF31_2828 ENOG4105DBK s4 domain protein BF31_2830 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF31_2833 ENOG4105C34 Pseudouridine synthase BF31_2838 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BF31_284 ENOG4105WEF catalase BF31_2849 ENOG4105DC7 peptidase M24 BF31_2850 ENOG4105F23 Fibronectin-binding protein BF31_2852 ENOG4105DSJ YicC domain protein BF31_2856 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BF31_2857 ENOG4105C25 Primosomal protein n' BF31_2858 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF31_2860 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF31_2862 ENOG4108ZF3 Phosphatase BF31_2863 ENOG4105D9P serine threonine protein kinase BF31_2864 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BF31_2865 ENOG4105DJV ribulose-phosphate 3-epimerase BF31_2866 ENOG4105FJ0 thiamine BF31_2868 ENOG4108ZAA Alkaline-shock protein BF31_2869 ENOG4105DP4 dak2 domain fusion protein ylov BF31_2870 ENOG4105CB5 ATP-dependent DNA helicase recG BF31_2873 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BF31_2874 ENOG4105CHR reductase BF31_2877 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BF31_2878 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BF31_2882 ENOG4105VB6 UPF0109 protein BF31_2887 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BF31_2890 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BF31_2892 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF31_2894 ENOG4108HE4 integrase family BF31_290 ENOG4105C19 ABC transporter BF31_2902 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BF31_2903 ENOG4105KNE Phosphatidate cytidylyltransferase BF31_2904 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF31_2905 ENOG4105DZP Membrane-associated zinc metalloprotease BF31_2907 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF31_2909 ENOG4105CHV Transcription elongation factor NusA BF31_291 ENOG4107RBB ABC transporter, permease BF31_2910 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BF31_2911 ENOG4105VHM ribosomal protein BF31_2913 ENOG4105W7A Protein of unknown function (DUF503) BF31_2915 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BF31_2916 ENOG4105DTN riboflavin biosynthesis protein ribF BF31_292 ENOG41069ER domain protein BF31_2920 ENOG4105C1V Peptidase, M16 BF31_2922 ENOG4105E35 Dipicolinate synthase subunit A BF31_2923 ENOG4108S0H Dipicolinic acid synthetase, b subunit BF31_2924 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF31_2926 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF31_2928 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BF31_2930 ENOG4107QZI cell division protein FtsK BF31_2931 ENOG4105FDP GntR family transcriptional regulator BF31_2932 ENOG4105DIH basic membrane BF31_2933 ENOG4108JQ9 ABC transporter BF31_2934 ENOG4105UIB (ABC) transporter BF31_2935 ENOG4105UIB (ABC) transporter BF31_2939 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BF31_2940 ENOG4105XZV Protein of unknown function (DUF3243) BF31_2943 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BF31_2948 ENOG4105D48 metallophosphoesterase BF31_2949 ENOG4105MCT stage V sporulation protein S BF31_2950 ENOG4108IGT Dipeptidase BF31_2951 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BF31_2952 ENOG4105DQU oxidoreductase, subunit beta BF31_2953 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF31_2958 ENOG4105DA5 (ABC) transporter BF31_296 ENOG4105VZJ PTS System BF31_2963 ENOG4107QHE Choloylglycine hydrolase BF31_2965 ENOG410890F Dynamin family BF31_2966 ENOG4105E0M Sulfatase BF31_2967 ENOG4107R6R udp-galactopyranose mutase BF31_2968 ENOG4105F0V Cell wall hydrolase BF31_297 ENOG4105VCP PTS System BF31_2972 ENOG4107YEI lmbE family BF31_2973 ENOG4107TTQ Alpha beta hydrolase fold BF31_2976 ENOG41067MG lrgb family BF31_2979 ENOG4105BZU Histidine kinase BF31_298 ENOG4105EMD TRANSCRIPTIONal BF31_2980 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BF31_2986 ENOG4105D03 DNA-3-methyladenine glycosylase II BF31_2987 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF31_2989 ENOG4105CGK Exodeoxyribonuclease III BF31_2994 ENOG4105E0A ABC, transporter BF31_2995 ENOG4105NIV Esterase BF31_2997 ENOG4105VPX protein, conserved in bacteria BF31_2998 ENOG410681U heavy metal transport detoxification protein BF31_2999 ENOG4105C59 p-type ATPase BF31_3000 ENOG4105K70 DNA-binding protein BF31_3001 ENOG4105TMB Formate nitrite transporter BF31_3005 ENOG4105C85 amino acid BF31_3008 ENOG4108SJC Membrane BF31_3009 ENOG4107QW4 alcohol dehydrogenase BF31_3010 ENOG4107QW4 alcohol dehydrogenase BF31_3011 ENOG4105E98 transcriptional regulator DeoR family BF31_3012 ENOG4105DE4 1-phosphofructokinase BF31_3013 ENOG4105DM4 PTS System BF31_3014 ENOG41069ER domain protein BF31_3021 ENOG4106F1P AAA ATPase, central domain protein BF31_3022 ENOG4105EN6 Membrane BF31_3023 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF31_3024 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF31_3025 ENOG4105CXI aluminum resistance protein BF31_3026 ENOG4105KV4 Transcriptional regulator BF31_3027 ENOG4105C5F glutamine synthetase BF31_303 ENOG4108KGH TRANSCRIPTIONal BF31_3048 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BF31_305 ENOG41087NI Sulfite exporter TauE/SafE BF31_306 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BF31_308 ENOG41085GJ domain protein BF31_3088 ENOG4105XSJ toxin secretion phage lysis holin BF31_3089 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BF31_3097 ENOG4105K7K Transcriptional regulator BF31_310 ENOG4105VFE sira family BF31_3101 ENOG4108SVB resolvase BF31_3103 ENOG4105CGH 5'-nucleotidase BF31_3106 ENOG4105D5T phosphonate abc transporter BF31_3109 ENOG4105D7V transposase BF31_311 ENOG4107TPS domain protein BF31_3113 ENOG4105BZ1 (ABC) transporter BF31_3114 ENOG4105BZ1 (ABC) transporter BF31_3117 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF31_312 ENOG4105VFE sira family BF31_3122 ENOG41067MG lrgb family BF31_3123 ENOG4105VAW lrga family BF31_3124 ENOG4107RSM transcriptional regulator BF31_3126 ENOG4107QIV Cytochrome c biogenesis protein BF31_313 ENOG4105XTG Pfam:DUF156 BF31_3137 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BF31_314 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BF31_3142 ENOG4108903 Formimidoylglutamase BF31_3143 ENOG4108VJ1 Transcriptional regulator (CarD family BF31_3144 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF31_3145 ENOG4105CBC glutamate synthase BF31_3146 ENOG4105CK7 Sodium proline symporter BF31_3147 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BF31_3148 ENOG4105FBA Phospholipase Carboxylesterase BF31_3149 ENOG4105BZU Histidine kinase BF31_3151 ENOG4107AYK membrAne BF31_3160 ENOG4105CEY Amp-dependent synthetase and ligase BF31_3161 ENOG4107ZYJ bioY protein BF31_3162 ENOG4107F3J Amp-dependent synthetase and ligase BF31_3166 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF31_3168 ENOG4105E5W Transporter BF31_3173 ENOG4108I0Z Aconitate hydratase BF31_3174 ENOG4108JJA ABC, transporter BF31_3176 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF31_3177 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF31_3183 ENOG4105W8X HesB YadR YfhF-family protein BF31_3184 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF31_3185 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BF31_3187 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF31_3188 ENOG4105C0H protease BF31_3189 ENOG4105K4P CoA-binding domain protein BF31_319 ENOG4105ED1 spovr family BF31_3190 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF31_3192 ENOG4105D9R oxidoreductase BF31_3194 ENOG4105CIG ABC transporter BF31_3198 ENOG4105EMN RNA polymerase sigma factor BF31_32 ENOG4105ECB domain protein BF31_320 ENOG4107Y03 Nitroreductase BF31_3200 ENOG4108KGH TRANSCRIPTIONal BF31_3201 ENOG4107QJT sodium dicarboxylate symporter BF31_3213 ENOG4105E1K spore germination protein BF31_3215 ENOG4108JB9 formate dehydrogenase BF31_3217 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BF31_3218 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF31_3220 ENOG4105TMB Formate nitrite transporter BF31_3221 ENOG4105D06 uba thif-type nad fad binding protein BF31_3222 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF31_3223 ENOG4108ZAF Molybdopterin BF31_3225 ENOG4105D1F ATP-binding protein BF31_3228 ENOG410696E Membrane BF31_3229 ENOG4105FR1 rard protein BF31_3231 ENOG4105EWU Squalene--hopene cyclase BF31_3233 ENOG4105CHR reductase BF31_3234 ENOG4105C26 Dehydrogenase BF31_3236 ENOG4108IA2 Sodium pantothenate symporter BF31_3239 ENOG4106IQC argininosuccinate lyase BF31_3241 ENOG410904N short-chain dehydrogenase reductase BF31_3245 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BF31_3249 ENOG4105VEQ Cold shock protein BF31_325 ENOG4108B31 Spore germination protein BF31_3253 ENOG4108R1P BF31_3255 ENOG41073R8 VanW family BF31_3256 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF31_3258 ENOG4105KT7 mgtC SapB transporter BF31_3260 ENOG4105E39 Enoyl-CoA hydratase BF31_3261 ENOG4105K64 Glycosyl transferase, family 2 BF31_3263 ENOG4108UT6 Transferase hexapeptide repeat containing protein BF31_3267 ENOG4105CQB FAD linked oxidase domain protein BF31_3268 ENOG4105C09 Bile acid BF31_3270 ENOG4105RHY Pfam:UPF0157 BF31_3276 ENOG4105CIS alcohol dehydrogenase BF31_3277 ENOG41082BM Transcriptional regulator, arsr family BF31_3281 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF31_3287 ENOG4108A04 Beta-lactamase BF31_3288 ENOG4105DPN Oligoendopeptidase f BF31_3289 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BF31_3290 ENOG4105E5K Alpha-amylase BF31_3292 ENOG4105C98 muts2 protein BF31_3296 ENOG4107V2S Transcriptional regulator BF31_3298 ENOG4107CUJ Protein of unknown function (DUF2690) BF31_3302 ENOG4107ZY0 Phenazine biosynthesis-like protein BF31_3303 ENOG4105NX3 Membrane BF31_3304 ENOG4105DQ5 transport system permease protein BF31_3305 ENOG4105EHG Permease protein BF31_3307 ENOG4108MES Periplasmic binding protein BF31_3311 ENOG4107R3E Citrate transporter BF31_3313 ENOG4108TN2 lmbE family BF31_332 ENOG4105C5Y PTS System BF31_3320 ENOG4105CIS alcohol dehydrogenase BF31_3327 ENOG4105H3G oxidoreductase BF31_3329 ENOG4105ED2 Beta-lactamase BF31_3334 ENOG4107YXZ hydrolase, family 25 BF31_3338 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BF31_3343 ENOG4105KAF membrAne BF31_3353 ENOG4108ZJ4 polysaccharide deacetylase BF31_3357 ENOG4105KVH Transcriptional regulator BF31_3358 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BF31_3362 ENOG4105CHR reductase BF31_3364 ENOG4105JAB phenazine biosynthesis protein, phzf family BF31_3371 ENOG4105KVH Transcriptional regulator BF31_3372 ENOG4105KVH Transcriptional regulator BF31_3373 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BF31_3375 ENOG4105D9R oxidoreductase BF31_3376 ENOG4108TZY GntR Family Transcriptional Regulator BF31_3377 ENOG4105KVH Transcriptional regulator BF31_3383 ENOG4105C44 Serine transporter BF31_3384 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BF31_3387 ENOG4105F27 Major Facilitator BF31_3388 ENOG4105CV8 reductase BF31_339 ENOG4105C7N Xanthine uracil vitamin C permease BF31_3392 ENOG4105D4Y metalloprotease BF31_3393 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BF31_3396 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BF31_3397 ENOG4105CIS alcohol dehydrogenase BF31_3398 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF31_3399 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF31_3402 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF31_3403 ENOG4105C6Z Gluconate BF31_3404 ENOG4105CMG Carbohydrate kinase BF31_3405 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BF31_3406 ENOG4105XDF Protein of unknown function (DUF1272) BF31_3407 ENOG4105DDN Pentapeptide repeat-containing protein BF31_3410 ENOG4105C37 (CBS) domain BF31_3416 ENOG4105EV4 Multidrug resistance protein mdtH BF31_3418 ENOG4105DMQ Methyltransferase BF31_342 ENOG4108INS Transcriptional regulator BF31_3423 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF31_3424 ENOG4105C31 Tryptophanyl-tRNA synthetase BF31_3426 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF31_3428 ENOG4108UW5 maltose o-acetyltransferase BF31_3429 ENOG4106UW1 Major Facilitator superfamily BF31_3430 ENOG4105DKQ ROK family BF31_3431 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BF31_3443 ENOG4105CJ1 ABC, transporter BF31_3445 ENOG4108PSK reductase BF31_3449 ENOG4108RCM Nitroreductase BF31_3450 ENOG4105KVH Transcriptional regulator BF31_3453 ENOG4105CUT histidyl-tRNA synthetase BF31_3454 ENOG4108Z66 YbaK ebsC protein BF31_3456 ENOG41067QW Transcriptional regulator BF31_3459 ENOG4108K8S endonuclease I BF31_3464 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF31_3465 ENOG4108JJB ABC transporter BF31_3471 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF31_3473 ENOG4105CRW Short chain fatty acid transporter BF31_3475 ENOG4105KBX Transcriptional regulator, TetR family BF31_3476 ENOG4105KPY Small multidrug resistance protein BF31_3477 ENOG4105RXJ BF31_3479 ENOG41069JR BF31_3480 ENOG4105DA5 (ABC) transporter BF31_3484 ENOG4105CZM Major Facilitator BF31_3485 ENOG4107MII Sugar-specific transcriptional regulator TrmB BF31_3487 ENOG4108ISG Major Facilitator BF31_3495 ENOG4105HIR S-layer domain protein BF31_3498 ENOG410874W AraC family transcriptional regulator BF31_3499 ENOG41082W1 Cupin 2, conserved barrel domain protein BF31_35 ENOG4105NA0 Transcriptional regulator BF31_3502 ENOG4108AEY RNA polymerase sigma factor BF31_3506 ENOG4108JQ1 Dehydrogenase BF31_3509 ENOG4105DVH amino acid BF31_351 ENOG4105DWF phosphomethylpyrimidine kinase BF31_3511 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BF31_3514 ENOG4108JPW Aminotransferase BF31_3516 ENOG4105EJQ L-serine dehydratase BF31_3517 ENOG4105C44 Serine transporter BF31_352 ENOG4105D06 uba thif-type nad fad binding protein BF31_3520 ENOG4108JGH Tetr family transcriptional regulator BF31_3521 ENOG4105EQ0 Major Facilitator superfamily BF31_3522 ENOG4105MZU cell filamentation protein BF31_3525 ENOG4107QJQ Mate efflux family protein BF31_3530 ENOG4105C8Q Methyl-accepting chemotaxis BF31_3533 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF31_3541 ENOG4105TRI Hydrolase BF31_3547 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF31_3549 ENOG4106P55 Transcriptional regulator BF31_355 ENOG41080HI glycine oxidase BF31_3551 ENOG4107QR9 Iron-sulfur cluster binding protein BF31_3552 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BF31_3553 ENOG4105DJB Major Facilitator Superfamily BF31_3554 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF31_3556 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BF31_3557 ENOG4108U05 Transcriptional regulator BF31_356 ENOG4108VEU Thiamine monophosphate synthase BF31_3560 ENOG4105BZU Histidine kinase BF31_3563 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BF31_3564 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF31_3567 ENOG4105JQZ Methyltransferase BF31_3568 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF31_3570 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BF31_3571 ENOG4108NNI Beta-lactamase domain-containing protein BF31_3574 ENOG4105VZ8 Transcriptional regulator BF31_358 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF31_3580 ENOG4105K6H D-cysteine desulfhydrase BF31_3585 ENOG41062D9 Histidine kinase BF31_3586 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF31_3589 ENOG4105IIP Membrane BF31_3591 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF31_3592 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BF31_360 ENOG4105ETU transcriptional activator (TenA BF31_3606 ENOG4108YXU transcriptional regulator AsnC family BF31_3607 ENOG4105CHR reductase BF31_3609 ENOG4105F7F Chaperone BF31_3613 ENOG41085FC arsR family transcriptional regulator BF31_3614 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BF31_3615 ENOG4105D6J arsenicaL-resistance protein BF31_3621 ENOG4105DIK (ABC) transporter BF31_3622 ENOG4105CC5 ABC transporter BF31_3623 ENOG4105DSE periplasmic solute binding protein BF31_3624 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BF31_3625 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF31_3627 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BF31_3628 ENOG4108TWJ NADH dehydrogenase subunit 5 BF31_3631 ENOG4105CVP deoxyribo-dipyrimidine photolyase BF31_3632 ENOG4108606 TspO/MBR family BF31_364 ENOG41080XQ Signal transduction protein with cbs domains BF31_3640 ENOG41090MY MarR family Transcriptional regulator BF31_3646 ENOG4105CHJ isochorismatase hydrolase BF31_3648 ENOG4105CH6 catalase BF31_3649 ENOG4105CGH 5'-nucleotidase BF31_3657 ENOG4105CSV Glutaminase BF31_3662 ENOG4108Q8B Spore germination protein BF31_3663 ENOG4108NHD germination protein BF31_3664 ENOG4108NHD germination protein BF31_3666 ENOG4105C6K Malic enzyme BF31_3668 ENOG4105II7 pyrroline-5-carboxylate reductase BF31_3670 ENOG4105CUB amino acid BF31_3671 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF31_3673 ENOG4108IMY Transcriptional regulator BF31_3674 ENOG4105HDK L-asparaginase BF31_3675 ENOG4108IJ0 Aspartate ammonia-lyase BF31_3678 ENOG4105E2A Dehydrogenase BF31_3693 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF31_3699 ENOG4105DWD nucleoside recognition domain protein BF31_3703 ENOG4105FDT acyl-CoA dehydrogenase BF31_3705 ENOG4108ZHR arsR family transcriptional regulator BF31_3706 ENOG4108ZRV stage ii sporulation protein p BF31_3707 ENOG4106N3A copper homeostasis protein cutc BF31_3709 ENOG4107258 Transcriptional regulator BF31_3710 ENOG4105P4J Allophanate hydrolase, subunit 1 BF31_3717 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BF31_3719 ENOG4107RF6 penicillin-binding protein BF31_3727 ENOG4105F1N DNA alkylation repair BF31_3729 ENOG4108IQI permease BF31_3730 ENOG4105KNA -acetyltransferase BF31_3731 ENOG410635A Membrane BF31_3747 ENOG4108XET gCN5-related N-acetyltransferase BF31_3753 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF31_3755 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF31_3762 ENOG4105FS7 Transcriptional regulator BF31_3763 ENOG4108TVJ Nitroreductase BF31_3765 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF31_3777 ENOG4105CKK Glycosyl transferase, family 2 BF31_3782 ENOG4105CKK Glycosyl transferase, family 2 BF31_3787 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF31_3792 ENOG41068WN BF31_3794 ENOG4108WCX response regulator BF31_3796 ENOG41090T1 Membrane BF31_3799 ENOG4105VMP Transcriptional regulator BF31_3801 ENOG4105G6Z alkaline phosphatase BF31_3802 ENOG4105ECK Fatty Acid Desaturase BF31_3803 ENOG4105E0Y RtcB Protein BF31_3805 ENOG4107258 Transcriptional regulator BF31_3807 ENOG4105II7 pyrroline-5-carboxylate reductase BF31_3808 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BF31_3814 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BF31_3818 ENOG41061GT Aldolase BF31_3821 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BF31_3822 ENOG4105DKT Transcriptional regulator BF31_3824 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BF31_3826 ENOG4105D4B ABC, transporter BF31_3832 ENOG4105EMN RNA polymerase sigma factor BF31_3834 ENOG41069ER domain protein BF31_3842 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF31_3843 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BF31_3844 ENOG4105CIH Imidazole acetol-phosphate transaminase BF31_3848 ENOG41082JN Transcriptional regulator BF31_3849 ENOG4105EYF MMPL domain protein BF31_3850 ENOG4105EYF MMPL domain protein BF31_3852 ENOG4105C5H ABC transporter BF31_3853 ENOG4105E0M Sulfatase BF31_3854 ENOG4108ZCF integral membrane protein BF31_3856 ENOG4107VMI polysaccharide deacetylase BF31_3858 ENOG4107VC0 DNA alkylation repair enzyme BF31_3868 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BF31_3872 ENOG4105E09 nadh pyrophosphatase BF31_3877 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BF31_3878 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BF31_3879 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BF31_3881 ENOG4105C02 permease BF31_3890 ENOG4105DVE abc transporter atp-binding protein BF31_3896 ENOG4105CHM Aminotransferase BF31_3903 ENOG41089UC methyltransferase, type 11 BF31_3906 ENOG4107BMA Transglycosylase associated protein BF31_391 ENOG4105E2Z phosphate ABC transporter (Permease BF31_3910 ENOG4106K7D Major facilitator family transporter BF31_3911 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF31_3919 ENOG4105EPR degv family BF31_392 ENOG4105C8U phosphate abc transporter BF31_3922 ENOG4105DPN Oligoendopeptidase f BF31_3929 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF31_393 ENOG4105CVA phosphate BF31_3930 ENOG4105BZU Histidine kinase BF31_3931 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BF31_3939 ENOG4105DTQ mandelate racemase muconate lactonizing BF31_394 ENOG4105CE1 Ferrous iron transport protein b BF31_3942 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BF31_3943 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF31_3946 ENOG4107T5V SNARE associated Golgi BF31_395 ENOG4105CE1 Ferrous iron transport protein b BF31_3953 ENOG41080HI glycine oxidase BF31_3954 ENOG4105CTU Proline racemase BF31_3955 ENOG4105CTU Proline racemase BF31_3956 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF31_3957 ENOG4105C26 Dehydrogenase BF31_3958 ENOG4105BZG amino acid carrier protein BF31_396 ENOG4105CE1 Ferrous iron transport protein b BF31_3961 ENOG4108M1A Chitin-binding protein BF31_397 ENOG4108NHD germination protein BF31_3970 ENOG4105C9U ATP-dependent DNA helicase RecQ BF31_3974 ENOG4105EEM helicase BF31_3978 ENOG4108Z7F N-acetyltransferase BF31_3984 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF31_3993 ENOG4108M1A Chitin-binding protein BF31_3994 ENOG41082BV acetyltransferase BF31_3995 ENOG4105E66 phosphoriboisomerase A BF31_40 ENOG4105C1Q protoporphyrinogen oxidase BF31_400 ENOG4105E1V na solute symporter BF31_4000 ENOG4108IJ7 Glycine betaine BF31_4001 ENOG4107SQ8 Glycine betaine BF31_4007 ENOG4105RHY Pfam:UPF0157 BF31_4008 ENOG4105E1F short-chain dehydrogenase reductase BF31_401 ENOG4106CAD Protein of unknown function (DUF3311) BF31_4010 ENOG4107RUY (E1 component), alpha subunit BF31_4012 ENOG4107QKR Dehydrogenase BF31_4017 ENOG41062ES Transcriptional regulator BF31_4021 ENOG4105E98 transcriptional regulator DeoR family BF31_4025 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BF31_4031 ENOG4107Z3H Transcriptional regulator, TetR family BF31_4032 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BF31_4033 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BF31_4034 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BF31_4038 ENOG4105MSI germination protein ypeb BF31_404 ENOG4105E2S oxidase) subunit II BF31_4042 ENOG4108V3A UPF0421 protein BF31_4049 ENOG4105FDR Membrane BF31_405 ENOG4105BZ9 Cytochrome C oxidase, subunit I BF31_4051 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF31_4056 ENOG4108IUM Glycogen debranching enzyme BF31_4059 ENOG4105DY8 decarboxylase BF31_4064 ENOG4105PAD Hydrolase BF31_4069 ENOG4107VFR oxidoreductase BF31_4077 ENOG4105PKS Excinuclease abc c subunit domain protein BF31_4085 ENOG4105KWG Pfam:DUF1696 BF31_4086 ENOG4108NRW Phospholipase, patatin family BF31_4092 ENOG4108XI2 Domain of unknown function (DUF1963) BF31_4099 ENOG4108Z4K mutator MutT protein BF31_4100 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF31_4101 ENOG4105E09 nadh pyrophosphatase BF31_4103 ENOG4105FCD Major Facilitator BF31_4110 ENOG4107Y9U Membrane BF31_4115 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF31_4119 ENOG4107Y80 Major Facilitator superfamily BF31_4124 ENOG4108V4B ThiJ pfpI BF31_413 ENOG4105C7N Xanthine uracil vitamin C permease BF31_4130 ENOG4105FQP Beta-lactamase BF31_4132 ENOG4105CJN penicillin-binding protein BF31_4133 ENOG4105CB2 alcohol dehydrogenase BF31_4136 ENOG4108HGU Histidine kinase BF31_4139 ENOG4108JJB ABC transporter BF31_414 ENOG4105C85 amino acid BF31_4143 ENOG4107RF6 penicillin-binding protein BF31_4144 ENOG4105BZU Histidine kinase BF31_4146 ENOG410667J hydrolase BF31_4169 ENOG4105ETU transcriptional activator (TenA BF31_418 ENOG4105DUX Transporter BF31_4190 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF31_4191 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF31_4194 ENOG4105CPQ Dehydrogenase BF31_42 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BF31_420 ENOG4107D63 BF31_4200 ENOG4105CUV Homoserine Kinase BF31_4204 ENOG4107Y80 Major Facilitator superfamily BF31_4206 ENOG4105FQP Beta-lactamase BF31_4209 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF31_4209 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF31_421 ENOG4105VZ8 Transcriptional regulator BF31_4218 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF31_422 ENOG41069ER domain protein BF31_4220 ENOG4105T9C HD domain BF31_4223 ENOG4105DZ1 carboxypeptidase BF31_4226 ENOG4105DBI uridine monophosphokinase BF31_4227 ENOG4105WCN acetyltransferase BF31_4229 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF31_423 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF31_4230 ENOG4107QX3 carboxylase BF31_4231 ENOG4105E39 Enoyl-CoA hydratase BF31_4232 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BF31_4233 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BF31_4234 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF31_4235 ENOG4105C1G acyl-Coa dehydrogenase BF31_4238 ENOG4107Z3H Transcriptional regulator, TetR family BF31_424 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF31_4240 ENOG4105CJ1 ABC, transporter BF31_4243 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BF31_4244 ENOG4105CEP NADH dehydrogenase BF31_4245 ENOG4106ANW SMI1_KNR4 BF31_4247 ENOG4105BZU Histidine kinase BF31_4249 ENOG4105C5H ABC transporter BF31_4250 ENOG41067SE Tetr family transcriptional regulator BF31_4255 ENOG4108VXD carboxy-peptidase BF31_4258 ENOG4105VZ8 Transcriptional regulator BF31_4261 ENOG4105CGH 5'-nucleotidase BF31_4262 ENOG4105CGH 5'-nucleotidase BF31_4266 ENOG4105DH8 myo-inositol catabolism BF31_4267 ENOG4105D2N Aldolase BF31_4272 ENOG4105CK5 oxidoreductase BF31_4273 ENOG4105IE8 Alpha-ketoglutarate permease BF31_4274 ENOG4105ETE Transcriptional regulator (LacI family BF31_4275 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF31_4277 ENOG4107RF6 penicillin-binding protein BF31_4278 ENOG4107RF6 penicillin-binding protein BF31_4279 ENOG4107RF6 penicillin-binding protein BF31_4285 ENOG4105CIN aminoacyl-histidine dipeptidase BF31_4293 ENOG41090HR transcriptional regulator BF31_4294 ENOG4107RA9 decarboxylase BF31_4295 ENOG4108I0C methyltransferase BF31_4297 ENOG41088CC tellurite resistance protein tehB BF31_43 ENOG4105BZ4 penicillin-binding protein BF31_4301 ENOG4108RZE Tetr family transcriptional regulator BF31_4303 ENOG4105C1J atp-dependent rna helicase BF31_4306 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF31_4309 ENOG4107STF Involved in phosphonate degradation (By similarity) BF31_4311 ENOG4105RD7 BadF BadG BcrA BcrD BF31_4316 ENOG4105F32 YngK protein BF31_4321 ENOG4108KPJ rna polymerase sigma factor BF31_4326 ENOG4108JCI Transcriptional regulator BF31_4330 ENOG4105BZ1 (ABC) transporter BF31_4331 ENOG4105BZ1 (ABC) transporter BF31_4334 ENOG4108RPX mosc domain containing protein BF31_4335 ENOG4105DND Transcriptional regulator BF31_4338 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF31_4339 ENOG4107V2S Transcriptional regulator BF31_4347 ENOG410667J hydrolase BF31_4351 ENOG4105VEQ Cold shock protein BF31_4353 ENOG41068WN BF31_4355 ENOG4105C1Q protoporphyrinogen oxidase BF31_436 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF31_4361 ENOG4105WCN acetyltransferase BF31_4366 ENOG4105EYF MMPL domain protein BF31_4368 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF31_437 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BF31_4371 ENOG41081I9 integral membrane protein BF31_4377 ENOG4108D32 Methyltransferase BF31_438 ENOG4105CNN ABC, transporter BF31_4383 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF31_4387 ENOG4105C22 threonyL-tRNA synthetase BF31_4388 ENOG4105FE9 pseudouridine synthase BF31_439 ENOG4105C2J ABC transporter BF31_4392 ENOG4105BZG amino acid carrier protein BF31_4396 ENOG4105K70 DNA-binding protein BF31_4399 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF31_44 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BF31_4400 ENOG4105WQT MbtH domain protein BF31_4401 ENOG4105CEY Amp-dependent synthetase and ligase BF31_4402 ENOG4105WQI isochorismatase BF31_4403 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BF31_4404 ENOG4105E4F Isochorismate synthase BF31_4405 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BF31_4406 ENOG4105FCD Major Facilitator BF31_441 ENOG4108RVA ribokinase BF31_4410 ENOG4105EYH Exonuclease BF31_4411 ENOG4107RFY SbcCD D subunit BF31_4414 ENOG4105E39 Enoyl-CoA hydratase BF31_4415 ENOG4105N14 lysine exporter protein LysE YggA BF31_4417 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF31_4418 ENOG4105C1G acyl-Coa dehydrogenase BF31_4419 ENOG4105CR4 methylisocitrate lyase BF31_442 ENOG4105ETE Transcriptional regulator (LacI family BF31_4420 ENOG4105DXD 2-methylcitrate dehydratase BF31_4422 ENOG4105W8X HesB YadR YfhF-family protein BF31_4423 ENOG4105CZM Major Facilitator BF31_4424 ENOG4105BZ4 penicillin-binding protein BF31_443 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF31_4432 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF31_444 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF31_445 ENOG41067TZ transcriptional regulator, MarR family BF31_4451 ENOG4108IBT Inherit from COG: transposase BF31_4453 ENOG4105SZ6 Thioredoxin BF31_4454 ENOG410841Q phosphoesterase PA-phosphatase related protein BF31_4456 ENOG4108N23 SpoOM-related protein BF31_446 ENOG4105CXY transporter BF31_4464 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BF31_4465 ENOG4108JUB Transcriptional regulator BF31_4466 ENOG4108TSC N-acetyltransferase BF31_4467 ENOG4107S4Y M20 DapE family protein YgeY BF31_4470 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF31_4475 ENOG4105C37 (CBS) domain BF31_448 ENOG4108JQ7 (ABC) transporter BF31_4482 ENOG4105E90 ABC transporter BF31_4483 ENOG4108IJ8 ABC transporter BF31_4489 ENOG4105CMG Carbohydrate kinase BF31_449 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF31_4490 ENOG4105CMG Carbohydrate kinase BF31_4498 ENOG4106KNT transcriptional regulator BF31_45 ENOG4105CKV Membrane BF31_4500 ENOG4105WH1 Two component transcriptional regulator luxr family BF31_4501 ENOG4105BZU Histidine kinase BF31_4502 ENOG4105D8X mechanosensitive ion channel BF31_4509 ENOG4105F0I Aminotransferase BF31_451 ENOG4105DEF Extracellular solute-binding protein, family 5 BF31_4510 ENOG4108MES Periplasmic binding protein BF31_4514 ENOG4105CAQ asparagine synthetase BF31_4515 ENOG4107Y70 Heat shock protein BF31_4516 ENOG4108KF3 Electron transport protein SCO1 SenC BF31_4517 ENOG4105E8R UPF0173 metal-dependent hydrolase BF31_4518 ENOG4108RCR degv family BF31_4520 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BF31_4522 ENOG4108UT2 hemolysin iii BF31_4523 ENOG4105E9Q Acyl-transferase BF31_4524 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF31_4529 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BF31_453 ENOG41068KF Universal stress protein BF31_4533 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BF31_4538 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BF31_454 ENOG4105CHH sulfate transporter BF31_4540 ENOG4105KD7 acetyltransferase BF31_4543 ENOG4105C0A alcohol dehydrogenase BF31_4544 ENOG4105CY2 Citrate transporter BF31_4545 ENOG4107XGZ Hydrolase BF31_4549 ENOG4105C8J )-transporter BF31_4552 ENOG41062D9 Histidine kinase BF31_4553 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF31_4554 ENOG4107QPK )-transporter BF31_4555 ENOG4105BZW Glycerate kinase BF31_457 ENOG4105BZU Histidine kinase BF31_4574 ENOG4105EC2 ftsk spoIIIe BF31_4578 ENOG4105C5S asparaginyl-tRNA synthetase BF31_4579 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF31_458 ENOG4105NAE bifunctional deaminase-reductase domain protein BF31_4582 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF31_4588 ENOG4105C75 arginyL-tRNA synthetase BF31_4589 ENOG4107YX5 Pfam:DUF548 BF31_459 ENOG4105D29 Helix-turn-helix type 11 domain protein BF31_4593 ENOG41061H0 Monooxygenase BF31_4596 ENOG4108UUM single-stranded DNA-binding protein BF31_4599 ENOG4105C5H ABC transporter BF31_46 ENOG410905X membrane-flanked domain protein BF31_4603 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF31_4606 ENOG4105MCT stage V sporulation protein S BF31_4613 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF31_4614 ENOG4108IFG nitrite reductase, (NAD(P)H) BF31_4615 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BF31_4616 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF31_4617 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF31_4618 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF31_4623 ENOG4108ZAF Molybdopterin BF31_4624 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF31_4625 ENOG4105D06 uba thif-type nad fad binding protein BF31_4626 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF31_4627 ENOG4107V6Q Cyclic nucleotide-binding domain BF31_4632 ENOG4105R3A Nitrate reductase BF31_4633 ENOG4108IUE nitrate reductase beta subunit BF31_4637 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF31_464 ENOG4108IQI permease BF31_4640 ENOG4108V06 Glutathione peroxidase BF31_4645 ENOG4105EMN RNA polymerase sigma factor BF31_4646 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BF31_4648 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BF31_4649 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BF31_465 ENOG4105DRP amino acid AbC transporter BF31_4653 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF31_4658 ENOG4105KBJ sporulation protein ytfj BF31_466 ENOG4105EAD ABC transporter BF31_4667 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF31_467 ENOG4105CT1 (ABC) transporter BF31_4673 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF31_4674 ENOG4108JYZ YitT family BF31_4675 ENOG41087PP glycosyltransferase MGT family BF31_4678 ENOG4107RBS Methyltransferase BF31_4679 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF31_468 ENOG4105CDA abc transporter atp-binding protein BF31_4681 ENOG4108X4Q Hydrolase BF31_4686 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF31_4688 ENOG4108VXD carboxy-peptidase BF31_469 ENOG4105BZG amino acid carrier protein BF31_4690 ENOG4108ZRV stage ii sporulation protein p BF31_4694 ENOG4108Z7R Chaperone CsaA BF31_4698 ENOG4105C37 (CBS) domain BF31_4699 ENOG4105SXS Protein of unknown function (DUF456) BF31_470 ENOG4105CRN Aminoglycoside phosphotransferase BF31_4703 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF31_4704 ENOG4108S4H thioesterase Superfamily protein BF31_4706 ENOG4108PJD permease BF31_4709 ENOG4107T5V SNARE associated Golgi BF31_4713 ENOG4105CVJ phosphoglycerate mutase BF31_4718 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF31_472 ENOG4105E1K spore germination protein BF31_4720 ENOG4105K4T epimerase BF31_4722 ENOG4105DSE periplasmic solute binding protein BF31_4734 ENOG4105CKI cobalamin synthesis protein BF31_4735 ENOG4107QM2 Aldo Keto reductase BF31_4739 ENOG4105DEN Luciferase family BF31_4742 ENOG4108WPJ Ferritin-like domain BF31_4743 ENOG4108K88 Membrane BF31_4746 ENOG4105C8Q Methyl-accepting chemotaxis BF31_4751 ENOG4107XZQ multidrug resistance protein BF31_4752 ENOG4107SET aldo keto reductase BF31_4753 ENOG4105YVS arsR family transcriptional regulator BF31_4755 ENOG4105KRN Transcriptional regulator, abrb family BF31_476 ENOG4105CG3 alpha amylase, catalytic region BF31_4766 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF31_4768 ENOG4107RCC Major Facilitator Superfamily BF31_4769 ENOG4105YWU small acid-soluble spore protein BF31_477 ENOG4105C5Y PTS System BF31_4770 ENOG4108WBH protein TIM barrel BF31_4773 ENOG4105CEY Amp-dependent synthetase and ligase BF31_4774 ENOG4105DUU IucA IucC family protein BF31_4776 ENOG4105VRR gCN5-related N-acetyltransferase BF31_4777 ENOG4105KT7 mgtC SapB transporter BF31_4779 ENOG4107VMI polysaccharide deacetylase BF31_478 ENOG4107414 GntR family transcriptional regulator BF31_4780 ENOG4105BZU Histidine kinase BF31_4781 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF31_4783 ENOG4108KGH TRANSCRIPTIONal BF31_4788 ENOG4105D6E homoserine dehydrogenase BF31_479 ENOG4105D5Q Arginine ornithine antiporter BF31_4792 ENOG4108ZJ4 polysaccharide deacetylase BF31_4793 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BF31_4796 ENOG4105BZU Histidine kinase BF31_4797 ENOG4105EFI regulatoR BF31_4798 ENOG4105BZ1 (ABC) transporter BF31_4799 ENOG4105BZ1 (ABC) transporter BF31_480 ENOG4105BZU Histidine kinase BF31_4807 ENOG4108JJ8 (ABC) transporter BF31_4808 ENOG4108JJ9 ABC, transporter BF31_4809 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF31_4810 ENOG4105C4M (Ubiquinol oxidase) subunit I BF31_4812 ENOG4105YGB Transcriptional regulator BF31_4816 ENOG4105SKE transcriptional Regulator LysR family BF31_4818 ENOG4105C32 Amino acid ABC transporter (Permease) BF31_4819 ENOG4108IV0 ABC, transporter BF31_4820 ENOG4105C0Z ABC transporter BF31_4822 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF31_4823 ENOG4108Z7G MaoC domain protein dehydratase BF31_4827 ENOG4105CKI cobalamin synthesis protein BF31_4829 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF31_483 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF31_4830 ENOG4106F5Q Membrane BF31_4831 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF31_4833 ENOG4108TVJ Nitroreductase BF31_4834 ENOG4107ZXU DSBA oxidoreductase BF31_4835 ENOG4108Z40 Transcriptional regulator BF31_4836 ENOG4105GZI Transcriptional regulator BF31_4837 ENOG4107RT3 EamA-like transporter family BF31_4839 ENOG4105KTB nuclear export factor GLE1 BF31_484 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BF31_4840 ENOG4108T5E Copper resistance protein BF31_485 ENOG4107T89 von Willebrand factor, type A BF31_4850 ENOG4107R16 Multicopper oxidase BF31_4851 ENOG4107STQ Multicopper oxidase BF31_4852 ENOG4107RAQ aminopeptidase BF31_4858 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BF31_4859 ENOG4105D9N nucleoside BF31_4861 ENOG4107RHR regulatoR BF31_4866 ENOG4105C0X amino acid BF31_4867 ENOG4105C0X amino acid BF31_4869 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BF31_487 ENOG4105EXW epimerase dehydratase BF31_4871 ENOG4105C72 UPF0176 protein BF31_4872 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BF31_4877 ENOG41068WN BF31_4883 ENOG4108J59 Extracellular solute-binding protein, family 5 BF31_4884 ENOG4105F6J Alpha beta hydrolase fold BF31_4889 ENOG4105CYC Transferase BF31_489 ENOG4105DMQ Methyltransferase BF31_4890 ENOG4105DY9 regulatoR BF31_4892 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BF31_4893 ENOG4105C6X Major Facilitator BF31_4898 ENOG4105C7B Threonine dehydratase BF31_490 ENOG4105E0A ABC, transporter BF31_4900 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF31_4901 ENOG4108ZP8 Acetolactate synthase small subunit BF31_4902 ENOG4105C7K acetolactate synthase BF31_4903 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF31_4904 ENOG4105CHR reductase BF31_4905 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF31_4909 ENOG4106KE4 Dehydrogenase BF31_491 ENOG4108IHU transport system permease protein BF31_4912 ENOG4105H67 Protein of unknown function (DUF421) BF31_4913 ENOG4105X5K response regulator receiver protein BF31_4915 ENOG4105C8J )-transporter BF31_4919 ENOG4105C6T cysteine synthase BF31_492 ENOG4105DQ5 transport system permease protein BF31_4920 ENOG4105EU0 Major facilitator Superfamily BF31_4923 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF31_4926 ENOG4105DXI Major Facilitator superfamily BF31_4927 ENOG4105DXI Major Facilitator superfamily BF31_4928 ENOG4105CSR polyphosphate kinase 2 BF31_493 ENOG4108MES Periplasmic binding protein BF31_4936 ENOG4105FVX BF31_494 ENOG4105DUX Transporter BF31_4949 ENOG4105C6K Malic enzyme BF31_4950 ENOG4108IJ0 Aspartate ammonia-lyase BF31_4952 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BF31_4957 ENOG4105CJ1 ABC, transporter BF31_4964 ENOG4106BRA Membrane BF31_497 ENOG4105DAA L-lactate BF31_4971 ENOG4107QIV Cytochrome c biogenesis protein BF31_4975 ENOG4105EC3 peptidase S51, dipeptidase E BF31_4976 ENOG4107QJQ Mate efflux family protein BF31_4977 ENOG4107QJQ Mate efflux family protein BF31_498 ENOG4108IJ0 Aspartate ammonia-lyase BF31_4981 ENOG4105C9Q fumarate hydratase class II BF31_4982 ENOG4105DFD Na H antiporter BF31_4985 ENOG4108PJD permease BF31_4986 ENOG4105CKI cobalamin synthesis protein BF31_4987 ENOG4108UZ3 Transporter BF31_4988 ENOG4105DRR Transcriptional regulator, GntR family BF31_499 ENOG4105C37 (CBS) domain BF31_4990 ENOG4105PGM cation diffusion facilitator family transporter BF31_4994 ENOG4105CAQ asparagine synthetase BF31_5 ENOG41086D8 Transcriptional regulator BF31_500 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BF31_5001 ENOG4105CVJ phosphoglycerate mutase BF31_5008 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BF31_5009 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BF31_501 ENOG4105D9N nucleoside BF31_5010 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF31_5011 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF31_5012 ENOG4105DUM transcriptional regulator, lysR family BF31_5017 ENOG4105KAC Antibiotic biosynthesis monooxygenase BF31_502 ENOG4108KGH TRANSCRIPTIONal BF31_5021 ENOG4108RZE Tetr family transcriptional regulator BF31_5026 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF31_5027 ENOG4105KTQ flagellar basal-body rod protein BF31_5028 ENOG4105FZW flagellar biosynthesis regulator FlhF BF31_5029 ENOG4105D7B Flagellar biosynthesis protein flha BF31_503 ENOG41073R8 VanW family BF31_5030 ENOG4105D00 flagellar biosynthetic protein flhB BF31_5032 ENOG4105VS8 Flagellar biosynthetic protein fliq BF31_5033 ENOG4105CN7 Flagellar biosynthetic protein FliP BF31_5035 ENOG4105DD5 Flagellar motor switch protein BF31_5037 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF31_5038 ENOG4105E4C Lytic transglycosylase catalytic BF31_5039 ENOG4105I03 Flagellin BF31_5044 ENOG4107TVC Glycosyl transferase, family 2 BF31_5050 ENOG4105K64 Glycosyl transferase, family 2 BF31_5052 ENOG4107R88 Chemotaxis protein (CheV) BF31_5056 ENOG4105BZE flagellar hook protein, FlgE BF31_5063 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF31_5065 ENOG4107U2N Flagellar M-ring protein BF31_5066 ENOG41075Z6 flagellar hook-basal body complex protein fliE BF31_5067 ENOG4108ZC9 flagellar basal-body rod protein flgc BF31_5068 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BF31_5073 ENOG4105DTJ flagellar hook-associated protein BF31_5079 ENOG4105BZU Histidine kinase BF31_5082 ENOG4105DD5 Flagellar motor switch protein BF31_5083 ENOG4105CBS Chea signal transduction histidine kinase BF31_5084 ENOG4105CBS Chea signal transduction histidine kinase BF31_5085 ENOG4107YTP response regulator receiver protein BF31_5086 ENOG4105ER2 Ompa motb domain protein BF31_5087 ENOG4107R0U MotA TolQ exbB proton channel BF31_5089 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF31_510 ENOG4105DAP Nicotinate phosphoribosyltransferase BF31_5100 ENOG41080C8 DUF218 domain BF31_5101 ENOG4105H67 Protein of unknown function (DUF421) BF31_5103 ENOG4108Z5V transcriptional regulator, merr family BF31_5104 ENOG4105CN5 Metallo-Beta-Lactamase BF31_5105 ENOG4107RWR Sodium hydrogen exchanger BF31_5107 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF31_511 ENOG4105C59 p-type ATPase BF31_5120 ENOG41081VK Ribonuclease BF31_5124 ENOG4108SZE gCN5-related N-acetyltransferase BF31_5127 ENOG4105CPK Glycosyl transferase (Group 1 BF31_513 ENOG4105CUB amino acid BF31_5141 ENOG4106032 Glutathionylspermidine synthase BF31_5144 ENOG4105KHC sulfurtransferase BF31_5146 ENOG4108W0I acetyltransferase BF31_5148 ENOG410890F Dynamin family BF31_5150 ENOG4105DHF Membrane BF31_5151 ENOG4105C2W permease BF31_5153 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF31_5156 ENOG4105CTD carboxy-peptidase BF31_5157 ENOG4105DVT helicase BF31_5159 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BF31_5170 ENOG4105BZ4 penicillin-binding protein BF31_5172 ENOG4105CSM endonuclease III BF31_5176 ENOG4105YAC BF31_5177 ENOG4105DVT helicase BF31_518 ENOG4108JB9 formate dehydrogenase BF31_5184 ENOG4105CPK Glycosyl transferase (Group 1 BF31_5185 ENOG4105FJR Lmbe family BF31_5188 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BF31_5189 ENOG4108JYZ YitT family BF31_519 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF31_5195 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BF31_5196 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BF31_5197 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BF31_520 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF31_5200 ENOG41068YB TPR repeat-containing protein BF31_5201 ENOG4105CIH Imidazole acetol-phosphate transaminase BF31_5205 ENOG4105EAH synthase BF31_5207 ENOG4105XXQ heptaprenyl diphosphate synthase component I BF31_5210 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BF31_5216 ENOG41065D1 BF31_5217 ENOG4105S2F BF31_522 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF31_5224 ENOG4107RB3 L-asparaginase BF31_5225 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BF31_5230 ENOG4108S6Z Negative regulator of genetic competence BF31_5231 ENOG4107X2D transcriptional regulator, merr family BF31_5232 ENOG4107RGJ metallophosphoesterase BF31_5234 ENOG4105I7S Abortive infection protein BF31_5235 ENOG4105C9U ATP-dependent DNA helicase RecQ BF31_5236 ENOG4105T7X BF31_5238 ENOG4108SAX Membrane BF31_5241 ENOG4108WBT adenosyltransferase BF31_5242 ENOG4105BZU Histidine kinase BF31_5243 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF31_5244 ENOG4105CRE cytochrome C BF31_5245 ENOG4107TWT Cytochrome c biogenesis protein BF31_5247 ENOG4105FE9 pseudouridine synthase BF31_5249 ENOG4108JIC nucleoside recognition domain protein BF31_5250 ENOG4105DZ1 carboxypeptidase BF31_5251 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF31_5258 ENOG4105BZU Histidine kinase BF31_526 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF31_5261 ENOG4105I3N Conserved Protein BF31_5262 ENOG4105BZU Histidine kinase BF31_5265 ENOG4105BZ4 penicillin-binding protein BF31_5266 ENOG4107GRR phosphate transport regulator BF31_5267 ENOG4105CJ3 phosphate transporter BF31_527 ENOG4108UZ3 Transporter BF31_5271 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BF31_5276 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BF31_5280 ENOG4105WH1 Two component transcriptional regulator luxr family BF31_5281 ENOG4105ENE Histidine kinase BF31_5285 ENOG4105DFD Na H antiporter BF31_5289 ENOG4105C8J )-transporter BF31_529 ENOG4105C6K Malic enzyme BF31_5290 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF31_5291 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF31_5292 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF31_5294 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BF31_5295 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BF31_5299 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BF31_5301 ENOG4105E0M Sulfatase BF31_5302 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF31_5305 ENOG4107RVV histidinol phosphate phosphatase, hisj family BF31_531 ENOG4108MRH transcriptional regulatory protein BF31_5312 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BF31_5317 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BF31_5319 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF31_5320 ENOG4108ZP8 Acetolactate synthase small subunit BF31_5321 ENOG4105C7K acetolactate synthase BF31_5322 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF31_5327 ENOG4105KBJ sporulation protein ytfj BF31_5328 ENOG41063Y9 BF31_5329 ENOG4105CZN Potassium uptake protein BF31_5335 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF31_5336 ENOG4107QMU Mate efflux family protein BF31_5343 ENOG4105NQC Flavodoxin BF31_5348 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF31_5350 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF31_5351 ENOG4105EA8 2-Nitropropane dioxygenase BF31_5352 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF31_536 ENOG4105US7 Histidine kinase BF31_5360 ENOG4105CJ1 ABC, transporter BF31_5362 ENOG4105CZV ABC transporter BF31_5363 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF31_5364 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF31_5365 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF31_5367 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF31_5368 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BF31_537 ENOG4108STX response regulator BF31_5377 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BF31_5378 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BF31_538 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BF31_5380 ENOG4105BZU Histidine kinase BF31_5382 ENOG4106DF1 BF31_5384 ENOG41090MY MarR family Transcriptional regulator BF31_5385 ENOG4105BZU Histidine kinase BF31_5387 ENOG4105PXI polysaccharide deacetylase BF31_5389 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF31_539 ENOG4105BZ7 extracellular solute-binding protein family 1 BF31_5390 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF31_5395 ENOG4105E98 transcriptional regulator DeoR family BF31_5398 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BF31_5399 ENOG4107RCV ABC transporter, permease BF31_540 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BF31_5402 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF31_5404 ENOG4105C4Y ABC transporter BF31_5408 ENOG4105MWK D-amino acid dehydrogenase, small subunit BF31_541 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BF31_5410 ENOG4105CHR reductase BF31_5414 ENOG4108Z7G MaoC domain protein dehydratase BF31_5415 ENOG410681C small acid-soluble spore protein BF31_5418 ENOG4107TS3 membrane protein, TerC BF31_5419 ENOG4108QTI )-transporter BF31_542 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF31_5421 ENOG4106A3R peptidase BF31_5425 ENOG4105JXH GntR family transcriptional regulator BF31_5426 ENOG4105BZU Histidine kinase BF31_5427 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF31_543 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF31_5430 ENOG4105CQB FAD linked oxidase domain protein BF31_5431 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF31_5432 ENOG4105K4I Scp-like extracellular BF31_5434 ENOG4108YBP pseudouridine synthase BF31_5436 ENOG4105EYF MMPL domain protein BF31_5438 ENOG4107RUE extracellular solute-binding protein family 1 BF31_5439 ENOG4105D38 putrescine abc transporter BF31_5440 ENOG4105F38 ABC transporter, permease BF31_5441 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF31_5442 ENOG4105C26 Dehydrogenase BF31_5448 ENOG4105VFR signal peptidase BF31_5449 ENOG4105DZ1 carboxypeptidase BF31_5451 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BF31_5462 ENOG4105VZ8 Transcriptional regulator BF31_5464 ENOG4105C7S Dehydrogenase BF31_547 ENOG4105D4T Citrate transporter BF31_548 ENOG4108MRH transcriptional regulatory protein BF31_5482 ENOG4105DDQ anthranilate synthase BF31_5483 ENOG4105CRQ synthase (Component I) BF31_5484 ENOG4105CK7 Sodium proline symporter BF31_5489 ENOG4108WVJ 2'-5' rna ligase BF31_549 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BF31_5498 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BF31_5500 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BF31_5501 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BF31_5505 ENOG4107TVC Glycosyl transferase, family 2 BF31_5509 ENOG4105K64 Glycosyl transferase, family 2 BF31_551 ENOG4105DZ6 Band 7 protein BF31_5511 ENOG4105CNI cell division protein FtsW BF31_5514 ENOG4105EMS pseudouridine synthase BF31_5515 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BF31_5518 ENOG4105MIX Adenylate cyclase BF31_5519 ENOG4108Z18 K06886 hemoglobin BF31_5522 ENOG4105DPN Oligoendopeptidase f BF31_5524 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF31_5526 ENOG4108ZCF integral membrane protein BF31_5530 ENOG4105UQX Mate efflux family protein BF31_5531 ENOG4108JQ7 (ABC) transporter BF31_5533 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF31_5534 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF31_5537 ENOG4105C31 Tryptophanyl-tRNA synthetase BF31_554 ENOG4105C94 Transporter BF31_5540 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF31_5541 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF31_5546 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BF31_5548 ENOG4108KP7 hydrolase BF31_5550 ENOG41073B9 BF31_5551 ENOG4107AYK membrAne BF31_5553 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF31_5555 ENOG4105QNR S1 RNA binding domain protein BF31_5559 ENOG4105BZU Histidine kinase BF31_5560 ENOG4105CH6 catalase BF31_5561 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BF31_5562 ENOG4105CAQ asparagine synthetase BF31_5576 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BF31_5577 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BF31_558 ENOG4105CYN Serine protein kinase BF31_5580 ENOG4105XVF Competence transcription factor BF31_5583 ENOG4105VEQ Cold shock protein BF31_5586 ENOG4107QP3 malate synthase g BF31_5587 ENOG4105ZU5 s-layer protein BF31_5591 ENOG4105C8Q Methyl-accepting chemotaxis BF31_5592 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BF31_56 ENOG4105CKV Membrane BF31_560 ENOG4105BZU Histidine kinase BF31_5604 ENOG4105CNU cell division protein FtsK BF31_561 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BF31_5616 ENOG4106JUT Streptomycin 3''-adenylyltransferase BF31_5628 ENOG4105EKQ RNA-directed DNA polymerase BF31_563 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BF31_565 ENOG4107ZQN disulfide bond BF31_5650 ENOG4105EKQ RNA-directed DNA polymerase BF31_566 ENOG4108JQC penicillin-binding protein 1A BF31_5671 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF31_5678 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) BF31_5680 ENOG4108MEK Metal-binding protein YodA BF31_5682 ENOG4105DQ6 Transposase BF31_5684 ENOG4105DQ6 Transposase BF31_5687 ENOG4105DQ6 Transposase BF31_5689 ENOG4108IBT Inherit from COG: transposase BF31_5696 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF31_5698 ENOG4105KRN Transcriptional regulator, abrb family BF31_5725 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BF31_5733 ENOG4105DQ6 Transposase BF31_5734 ENOG4105DQ6 Transposase BF31_5738 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF31_5739 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF31_5743 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF31_5744 ENOG4106AKK s-layer domain-containing protein BF31_5750 ENOG4105DHF Membrane BF31_5796 ENOG4108J59 Extracellular solute-binding protein, family 5 BF31_5799 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF31_58 ENOG410905X membrane-flanked domain protein BF31_5809 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF31_5810 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF31_5824 ENOG4105K4H Nlp p60 protein BF31_5858 ENOG4107QJE Chromosome Partitioning Protein BF31_5863 ENOG4105DQ6 Transposase BF31_5869 ENOG4105EWC Purine nucleoside phosphorylase BF31_5887 ENOG4105C3F Signal peptidase i BF31_5895 ENOG4105N14 lysine exporter protein LysE YggA BF31_591 ENOG4105G5W regulator Fur family BF31_592 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF31_596 ENOG4108IUW ABC transporter BF31_598 ENOG4105CBC glutamate synthase BF31_599 ENOG4107NBY Membrane BF31_6 ENOG4108AEY RNA polymerase sigma factor BF31_600 ENOG4105BZ1 (ABC) transporter BF31_604 ENOG4106BXE BF31_605 ENOG4105CEN a g-specific adenine glycosylase BF31_606 ENOG41067AE Membrane-bound metal-dependent hydrolase BF31_612 ENOG4105ECP epimerase BF31_613 ENOG4105CI2 imidazolone-5-propionate hydrolase BF31_617 ENOG4105F1A Pyruvate formate-lyase BF31_620 ENOG4105C3I Nad-dependent epimerase dehydratase BF31_621 ENOG4107QQG Dehydrogenase BF31_623 ENOG4105CKK Glycosyl transferase, family 2 BF31_626 ENOG4108A04 Beta-lactamase BF31_628 ENOG4105CSV Glutaminase BF31_634 ENOG4108IQI permease BF31_636 ENOG4108JUB Transcriptional regulator BF31_638 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF31_65 ENOG4105K59 histidine triad (HIT) protein BF31_696 ENOG4105VTR Integrase BF31_697 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF31_70 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF31_705 ENOG4105UPD Calcium Proton BF31_706 ENOG410606W general stress protein BF31_709 ENOG4107ZTW SNARE associated Golgi BF31_71 ENOG4105EEM helicase BF31_712 ENOG4105C3F Signal peptidase i BF31_714 ENOG4108IPJ Membrane BF31_715 ENOG4105C59 p-type ATPase BF31_716 ENOG4107U9T Pfam:Ribonuclease_BN BF31_718 ENOG4105KJF protein tyrosine phosphatase BF31_722 ENOG4108TTB tellurium resistance protein BF31_723 ENOG4107TS3 membrane protein, TerC BF31_724 ENOG4106FN3 tellurium resistance protein BF31_725 ENOG4106FN3 tellurium resistance protein BF31_726 ENOG4108N0M stress protein BF31_729 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BF31_73 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF31_732 ENOG4105DEU major facilitator superfamily BF31_736 ENOG41062JF Transcriptional regulator BF31_74 ENOG4105C57 major facilitator superfamily BF31_741 ENOG4105C5H ABC transporter BF31_744 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF31_747 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BF31_753 ENOG4105CI1 PTS System BF31_755 ENOG4105C8Q Methyl-accepting chemotaxis BF31_756 ENOG4105C8Q Methyl-accepting chemotaxis BF31_758 ENOG4105EAB amino acid AbC transporter BF31_759 ENOG4105E5Q amino acid AbC transporter BF31_762 ENOG4105D2S major facilitator superfamily BF31_763 ENOG410756H nucleotidyltransferase BF31_767 ENOG4105BZU Histidine kinase BF31_771 ENOG4106UIA BF31_772 ENOG4106UIA BF31_776 ENOG4108V5C ABC transporter BF31_777 ENOG4105DQ5 transport system permease protein BF31_778 ENOG4105EHG Permease protein BF31_779 ENOG4107W7X Aldolase BF31_781 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BF31_782 ENOG4105D3R alkyl hydroperoxide reductase BF31_787 ENOG4105DFD Na H antiporter BF31_788 ENOG4105DTQ mandelate racemase muconate lactonizing BF31_79 ENOG4105EMN RNA polymerase sigma factor BF31_791 ENOG4108W15 Protein of unknown function (DUF1456) BF31_794 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF31_795 ENOG4105D9N nucleoside BF31_799 ENOG4105KPY Small multidrug resistance protein BF31_8 ENOG4107TVP HD domain protein BF31_800 ENOG4105C26 Dehydrogenase BF31_802 ENOG4108JPW Aminotransferase BF31_803 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BF31_804 ENOG4105CBD Diacylglycerol kinase BF31_808 ENOG4107I77 yiaA/B two helix domain BF31_809 ENOG410834F Transcriptional regulator BF31_810 ENOG4105D0U Arsenite-activated ATPase (ArsA) BF31_814 ENOG4105D01 (LipO)protein BF31_815 ENOG4108UMI ABC transporter, permease BF31_816 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF31_817 ENOG4108W2Y isochorismatase BF31_82 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BF31_829 ENOG4105C12 Phosphoribosylglycinamide synthetase BF31_831 ENOG4108V3E phosphoribosylglycinamide formyltransferase BF31_836 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BF31_838 ENOG4105C83 adenylosuccinate lyase BF31_839 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BF31_840 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BF31_845 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF31_849 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF31_85 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF31_855 ENOG4108SHN Glycosyl transferase, family 2 BF31_861 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF31_869 ENOG4105BZU Histidine kinase BF31_871 ENOG4105C7N Xanthine uracil vitamin C permease BF31_875 ENOG4108TYN CAAX amino terminal protease family protein BF31_878 ENOG4105C5H ABC transporter BF31_879 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF31_880 ENOG410801F ribosomal-protein-alanine acetyltransferase BF31_881 ENOG41072GX Peptidase M22 Glycoprotease BF31_882 ENOG4105K8N protein family UPF0079, ATPase BF31_89 ENOG4108MUZ hydrolase BF31_9 ENOG4107RN3 metallophosphoesterase BF31_902 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BF31_904 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF31_905 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BF31_908 ENOG4107ZXI Rhomboid family BF31_910 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF31_911 ENOG4105CPF Cell wall formation (By similarity) BF31_912 ENOG4105CPF Cell wall formation (By similarity) BF31_913 ENOG4108SC4 )-transporter BF31_915 ENOG4105ERH Fumarylacetoacetate hydrolase BF31_916 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BF31_923 ENOG410667J hydrolase BF31_924 ENOG4108JQ7 (ABC) transporter BF31_925 ENOG4105C3U ABC transporter BF31_926 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF31_928 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BF31_931 ENOG4105C5H ABC transporter BF31_935 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BF31_936 ENOG4108RE7 deoxyribonuclease BF31_939 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF31_94 ENOG4105EQ0 Major Facilitator superfamily BF31_943 ENOG4105F6E Acyl-transferase BF31_947 ENOG4105EGI Transcriptional regulator BF31_95 ENOG4108IND Tetr family transcriptional regulator BF31_950 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BF31_951 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF31_952 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF31_953 ENOG4105E0C molybdate abc transporter BF31_955 ENOG4107XDY Nicotinamide Mononucleotide Transporter BF31_956 ENOG4105II7 pyrroline-5-carboxylate reductase BF31_958 ENOG4108J59 Extracellular solute-binding protein, family 5 BF31_959 ENOG4108J59 Extracellular solute-binding protein, family 5 BF31_965 ENOG4108JQ7 (ABC) transporter BF31_966 ENOG4105C3U ABC transporter BF31_967 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF31_968 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF31_971 ENOG4105C2C drug resistance transporter, Bcr CflA BF31_974 ENOG4105IQ5 FAD linked oxidase domain protein BF31_976 ENOG4105EE1 crotonyl-CoA reductase BF31_977 ENOG4105D01 (LipO)protein BF31_978 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF31_979 ENOG4108UMI ABC transporter, permease BF31_98 ENOG4105D7V transposase BF31_980 ENOG4108PSK reductase BF31_988 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BF31_989 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BF31_99 ENOG4106D4I domain protein BF31_991 ENOG4105CMG Carbohydrate kinase BF31_992 ENOG4105CMG Carbohydrate kinase BF31_994 ENOG4108VQT Alpha beta hydrolase fold protein BF31_995 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BF31_997 ENOG4107U5W ybbr family BF31_998 ENOG4105C8B TIGR00159 family