locus-tag class description BZG08_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BZG08_00015 ENOG410848D S4 domain protein YaaA BZG08_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BZG08_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BZG08_00100 ENOG4105ZMH deoxynucleoside kinase BZG08_00110 ENOG4105GTG Isochorismatase BZG08_00120 ENOG4108Z6B deaminase BZG08_00130 ENOG4105C6E dna polymerase iii BZG08_00150 ENOG41067KS pro-sigma K processing BZG08_00185 ENOG4105CXN decarboxylase BZG08_00195 ENOG4105FA2 dna polymerase iii BZG08_00200 ENOG4105MA4 psp1 domain protein BZG08_00210 ENOG41060K3 Methyltransferase BZG08_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BZG08_00225 ENOG4105KRN Transcriptional regulator, abrb family BZG08_00235 ENOG4105F8V Hydrolase, tatD family BZG08_00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BZG08_00250 ENOG4105XFA sporulation peptidase YabG BZG08_00255 ENOG4105W42 Veg protein BZG08_00270 ENOG4105DFT pur operon repressor BZG08_00280 ENOG4105KME endoribonuclease L-psp BZG08_00295 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BZG08_00300 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BZG08_00310 ENOG4108JA2 transcriptioN-repair coupling factor BZG08_00315 ENOG4108M14 stage v sporulation protein t BZG08_00325 ENOG4108IY2 MazG family BZG08_00330 ENOG41082I2 s4 domain protein BZG08_00335 ENOG4105VYY sporulation protein yabp BZG08_00350 ENOG41060GV RNA binding s1 domain protein BZG08_00370 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BZG08_00375 ENOG4108UGV hypoxanthine phosphoribosyltransferase BZG08_00380 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BZG08_00395 ENOG4105C6T cysteine synthase BZG08_00400 ENOG4105CRQ synthase (Component I) BZG08_00405 ENOG4105DDQ anthranilate synthase BZG08_00410 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BZG08_00415 ENOG4105EEI dihydropteroate synthase BZG08_00420 ENOG4105KRF dihydroneopterin aldolase BZG08_00425 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BZG08_00435 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BZG08_00465 ENOG4108Z0C Uvrb UvrC protein BZG08_00480 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BZG08_00490 ENOG4105CTP PilT protein domain protein BZG08_00510 ENOG4105D7W serine acetyltransferase BZG08_00525 ENOG4105C2N RNA methyltransferase TrmH family group 3 BZG08_00530 ENOG4105M0M Tetracycline resistance protein BZG08_00535 ENOG4105QIV RNA polymerase BZG08_00550 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BZG08_00575 ENOG4107Y49 methyltransferase BZG08_00585 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BZG08_00590 ENOG4105XPM ribosomal protein BZG08_00695 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BZG08_00720 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BZG08_00730 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BZG08_00740 ENOG41067V7 50S ribosomal protein L36 BZG08_00770 ENOG4108JJB ABC transporter BZG08_00775 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BZG08_00780 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BZG08_00805 ENOG4105D1F ATP-binding protein BZG08_00820 ENOG4108NMV polysaccharide deacetylase BZG08_00910 ENOG4105C8B TIGR00159 family BZG08_00915 ENOG4107U5W ybbr family BZG08_00930 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BZG08_00935 ENOG4108VQT Alpha beta hydrolase fold protein BZG08_00945 ENOG4105CMG Carbohydrate kinase BZG08_00950 ENOG4105CMG Carbohydrate kinase BZG08_00960 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BZG08_00965 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BZG08_01005 ENOG4108UMI ABC transporter, permease BZG08_01010 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BZG08_01015 ENOG4105D01 (LipO)protein BZG08_01020 ENOG4105EE1 crotonyl-CoA reductase BZG08_01030 ENOG4105IQ5 FAD linked oxidase domain protein BZG08_01045 ENOG4105C2C drug resistance transporter, Bcr CflA BZG08_01060 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BZG08_01065 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BZG08_01070 ENOG4105C3U ABC transporter BZG08_01075 ENOG4108JQ7 (ABC) transporter BZG08_01105 ENOG4108J59 Extracellular solute-binding protein, family 5 BZG08_01110 ENOG4108J59 Extracellular solute-binding protein, family 5 BZG08_01120 ENOG4105II7 pyrroline-5-carboxylate reductase BZG08_01130 ENOG4107XDY Nicotinamide Mononucleotide Transporter BZG08_01140 ENOG4105E0C molybdate abc transporter BZG08_01150 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BZG08_01170 ENOG4105EGI Transcriptional regulator BZG08_01190 ENOG4105F6E Acyl-transferase BZG08_01215 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BZG08_01230 ENOG4108RE7 deoxyribonuclease BZG08_01235 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BZG08_01260 ENOG4105C5H ABC transporter BZG08_01275 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BZG08_01285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BZG08_01290 ENOG4105C3U ABC transporter BZG08_01320 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BZG08_01325 ENOG4105ERH Fumarylacetoacetate hydrolase BZG08_01340 ENOG4108SC4 )-transporter BZG08_01350 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BZG08_01365 ENOG4107ZXI Rhomboid family BZG08_01375 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BZG08_01380 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BZG08_01390 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BZG08_01490 ENOG4105K8N protein family UPF0079, ATPase BZG08_01495 ENOG41072GX Peptidase M22 Glycoprotease BZG08_01500 ENOG410801F ribosomal-protein-alanine acetyltransferase BZG08_01505 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BZG08_01510 ENOG4105C5H ABC transporter BZG08_01525 ENOG4108TYN CAAX amino terminal protease family protein BZG08_01545 ENOG4105C7N Xanthine uracil vitamin C permease BZG08_01555 ENOG4105BZU Histidine kinase BZG08_01585 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BZG08_01630 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BZG08_01650 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BZG08_01675 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BZG08_01680 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BZG08_01685 ENOG4105C83 adenylosuccinate lyase BZG08_01695 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BZG08_01720 ENOG4108V3E phosphoribosylglycinamide formyltransferase BZG08_01730 ENOG4105C12 Phosphoribosylglycinamide synthetase BZG08_01760 ENOG4105C4R Atp-dependent dna helicase BZG08_01790 ENOG4108W2Y isochorismatase BZG08_01800 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BZG08_01805 ENOG4108UMI ABC transporter, permease BZG08_01810 ENOG4105D01 (LipO)protein BZG08_01830 ENOG4105D0U Arsenite-activated ATPase (ArsA) BZG08_01835 ENOG410834F Transcriptional regulator BZG08_01860 ENOG4105CBD Diacylglycerol kinase BZG08_01865 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BZG08_01870 ENOG4108JPW Aminotransferase BZG08_01880 ENOG4105C26 Dehydrogenase BZG08_01885 ENOG4105KPY Small multidrug resistance protein BZG08_01905 ENOG4105D9N nucleoside BZG08_01910 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BZG08_01925 ENOG4108W15 Protein of unknown function (DUF1456) BZG08_01940 ENOG4105DTQ mandelate racemase muconate lactonizing BZG08_01950 ENOG4105DFD Na H antiporter BZG08_01970 ENOG4105D3R alkyl hydroperoxide reductase BZG08_01975 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BZG08_01985 ENOG4107W7X Aldolase BZG08_01990 ENOG4105EHG Permease protein BZG08_01995 ENOG4105DQ5 transport system permease protein BZG08_02000 ENOG4108V5C ABC transporter BZG08_02030 ENOG4106UIA BZG08_02035 ENOG4106UIA BZG08_02065 ENOG4105BZU Histidine kinase BZG08_02085 ENOG410756H nucleotidyltransferase BZG08_02090 ENOG4105D2S major facilitator superfamily BZG08_02105 ENOG4105E5Q amino acid AbC transporter BZG08_02110 ENOG4105EAB amino acid AbC transporter BZG08_02125 ENOG4105C8Q Methyl-accepting chemotaxis BZG08_02130 ENOG4105C8Q Methyl-accepting chemotaxis BZG08_02140 ENOG4105CI1 PTS System BZG08_02170 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BZG08_02185 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BZG08_02200 ENOG4105C5H ABC transporter BZG08_02225 ENOG41062JF Transcriptional regulator BZG08_02245 ENOG4105DEU major facilitator superfamily BZG08_02275 ENOG4108N0M stress protein BZG08_02280 ENOG4106FN3 tellurium resistance protein BZG08_02285 ENOG4106FN3 tellurium resistance protein BZG08_02290 ENOG4107TS3 membrane protein, TerC BZG08_02295 ENOG4108TTB tellurium resistance protein BZG08_02315 ENOG4105KJF protein tyrosine phosphatase BZG08_02325 ENOG4107U9T Pfam:Ribonuclease_BN BZG08_02335 ENOG4105C59 p-type ATPase BZG08_02340 ENOG4108IPJ Membrane BZG08_02360 ENOG4107ZTW SNARE associated Golgi BZG08_02375 ENOG410606W general stress protein BZG08_02380 ENOG4105UPD Calcium Proton BZG08_02420 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BZG08_02425 ENOG4105VTR Integrase BZG08_02430 ENOG4108IMY Transcriptional regulator BZG08_02740 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BZG08_02750 ENOG4108JUB Transcriptional regulator BZG08_02760 ENOG4108IQI permease BZG08_02795 ENOG4105CSV Glutaminase BZG08_02810 ENOG4108A04 Beta-lactamase BZG08_02825 ENOG4105CKK Glycosyl transferase, family 2 BZG08_02835 ENOG4107QQG Dehydrogenase BZG08_02840 ENOG4105C3I Nad-dependent epimerase dehydratase BZG08_02860 ENOG4105F1A Pyruvate formate-lyase BZG08_02880 ENOG4105CI2 imidazolone-5-propionate hydrolase BZG08_02885 ENOG4105ECP epimerase BZG08_02915 ENOG41067AE Membrane-bound metal-dependent hydrolase BZG08_02920 ENOG4105CEN a g-specific adenine glycosylase BZG08_02925 ENOG4106BXE BZG08_02945 ENOG4105BZ1 (ABC) transporter BZG08_02950 ENOG4107NBY Membrane BZG08_02955 ENOG4105CBC glutamate synthase BZG08_02965 ENOG4108IUW ABC transporter BZG08_02985 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BZG08_02990 ENOG4105G5W regulator Fur family BZG08_03110 ENOG4108JQC penicillin-binding protein 1A BZG08_03115 ENOG4107ZQN disulfide bond BZG08_03125 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BZG08_03135 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BZG08_03140 ENOG4105BZU Histidine kinase BZG08_03150 ENOG4105CYN Serine protein kinase BZG08_03175 ENOG4105C94 Transporter BZG08_03190 ENOG4105DZ6 Band 7 protein BZG08_03200 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BZG08_03210 ENOG4105D4T Citrate transporter BZG08_03230 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BZG08_03235 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BZG08_03240 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BZG08_03245 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BZG08_03250 ENOG4105BZ7 extracellular solute-binding protein family 1 BZG08_03255 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BZG08_03260 ENOG4108STX response regulator BZG08_03265 ENOG4105US7 Histidine kinase BZG08_03290 ENOG4108MRH transcriptional regulatory protein BZG08_03300 ENOG4105C6K Malic enzyme BZG08_03310 ENOG4108UZ3 Transporter BZG08_03315 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BZG08_03325 ENOG4105BZU Histidine kinase BZG08_03330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZG08_03340 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BZG08_03345 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BZG08_03350 ENOG4108JB9 formate dehydrogenase BZG08_03370 ENOG4105CUB amino acid BZG08_03385 ENOG4105C59 p-type ATPase BZG08_03390 ENOG4105DAP Nicotinate phosphoribosyltransferase BZG08_03425 ENOG41073R8 VanW family BZG08_03430 ENOG4108KGH TRANSCRIPTIONal BZG08_03435 ENOG4105D9N nucleoside BZG08_03440 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BZG08_03445 ENOG4105C37 (CBS) domain BZG08_03450 ENOG4108IJ0 Aspartate ammonia-lyase BZG08_03455 ENOG4105DAA L-lactate BZG08_03470 ENOG4105DUX Transporter BZG08_03475 ENOG4108MES Periplasmic binding protein BZG08_03480 ENOG4105DQ5 transport system permease protein BZG08_03485 ENOG4108IHU transport system permease protein BZG08_03490 ENOG4105E0A ABC, transporter BZG08_03495 ENOG4105DMQ Methyltransferase BZG08_03515 ENOG4107T89 von Willebrand factor, type A BZG08_03520 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BZG08_03525 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BZG08_03540 ENOG4105BZU Histidine kinase BZG08_03545 ENOG4105D5Q Arginine ornithine antiporter BZG08_03550 ENOG4107414 GntR family transcriptional regulator BZG08_03555 ENOG4105C5Y PTS System BZG08_03560 ENOG4105CG3 alpha amylase, catalytic region BZG08_03575 ENOG4105E1K spore germination protein BZG08_03585 ENOG4105CRN Aminoglycoside phosphotransferase BZG08_03590 ENOG4105BZG amino acid carrier protein BZG08_03595 ENOG4105CDA abc transporter atp-binding protein BZG08_03600 ENOG4105CT1 (ABC) transporter BZG08_03605 ENOG4105EAD ABC transporter BZG08_03610 ENOG4105DRP amino acid AbC transporter BZG08_03615 ENOG4108IQI permease BZG08_03640 ENOG4105D29 Helix-turn-helix type 11 domain protein BZG08_03645 ENOG4105NAE bifunctional deaminase-reductase domain protein BZG08_03650 ENOG4105BZU Histidine kinase BZG08_03665 ENOG4105CHH sulfate transporter BZG08_03670 ENOG41068KF Universal stress protein BZG08_03680 ENOG4105DEF Extracellular solute-binding protein, family 5 BZG08_03690 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BZG08_03695 ENOG4108JQ7 (ABC) transporter BZG08_03700 ENOG4105C3U ABC transporter BZG08_03705 ENOG4105CXY transporter BZG08_03710 ENOG41067TZ transcriptional regulator, MarR family BZG08_03720 ENOG4105ETE Transcriptional regulator (LacI family BZG08_03725 ENOG4108RVA ribokinase BZG08_03735 ENOG4105C2J ABC transporter BZG08_03740 ENOG4105CNN ABC, transporter BZG08_03745 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BZG08_03750 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BZG08_03810 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BZG08_03815 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BZG08_03820 ENOG41069ER domain protein BZG08_03825 ENOG4105VZ8 Transcriptional regulator BZG08_03830 ENOG4107D63 BZG08_03840 ENOG4105DUX Transporter BZG08_03860 ENOG4105C85 amino acid BZG08_03865 ENOG4105C7N Xanthine uracil vitamin C permease BZG08_03905 ENOG4105BZ9 Cytochrome C oxidase, subunit I BZG08_03910 ENOG4105E2S oxidase) subunit II BZG08_03915 ENOG4108IQI permease BZG08_03930 ENOG4106CAD Protein of unknown function (DUF3311) BZG08_03935 ENOG4105E1V na solute symporter BZG08_03950 ENOG4108NHD germination protein BZG08_03960 ENOG4105CE1 Ferrous iron transport protein b BZG08_03965 ENOG4105CE1 Ferrous iron transport protein b BZG08_03970 ENOG4105CE1 Ferrous iron transport protein b BZG08_03975 ENOG4105CVA phosphate BZG08_03980 ENOG4105C8U phosphate abc transporter BZG08_03985 ENOG4105E2Z phosphate ABC transporter (Permease BZG08_04110 ENOG41080XQ Signal transduction protein with cbs domains BZG08_04135 ENOG4105ETU transcriptional activator (TenA BZG08_04145 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BZG08_04155 ENOG4108VEU Thiamine monophosphate synthase BZG08_04160 ENOG41080HI glycine oxidase BZG08_04175 ENOG4105D06 uba thif-type nad fad binding protein BZG08_04180 ENOG4105DWF phosphomethylpyrimidine kinase BZG08_04235 ENOG4108INS Transcriptional regulator BZG08_04250 ENOG4105C7N Xanthine uracil vitamin C permease BZG08_04280 ENOG4105C5Y PTS System BZG08_04340 ENOG4107Y03 Nitroreductase BZG08_04345 ENOG4105ED1 spovr family BZG08_04375 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BZG08_04380 ENOG4105XTG Pfam:DUF156 BZG08_04385 ENOG4105VFE sira family BZG08_04390 ENOG4107TPS domain protein BZG08_04395 ENOG4105VFE sira family BZG08_04410 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BZG08_04415 ENOG41087NI Sulfite exporter TauE/SafE BZG08_04425 ENOG4108KGH TRANSCRIPTIONal BZG08_04450 ENOG4105EMD TRANSCRIPTIONal BZG08_04455 ENOG4105VCP PTS System BZG08_04460 ENOG4105VZJ PTS System BZG08_04480 ENOG41069ER domain protein BZG08_04485 ENOG4107RBB ABC transporter, permease BZG08_04490 ENOG4105C19 ABC transporter BZG08_04520 ENOG4105WEF catalase BZG08_04555 ENOG4107T5V SNARE associated Golgi BZG08_04595 ENOG4105CUB amino acid BZG08_04600 ENOG4107RWR Sodium hydrogen exchanger BZG08_04610 ENOG4106KNT transcriptional regulator BZG08_04645 ENOG4108PCN EamA-like transporter family BZG08_04650 ENOG4108YXU transcriptional regulator AsnC family BZG08_04660 ENOG4105KPY Small multidrug resistance protein BZG08_04665 ENOG4105KPY Small multidrug resistance protein BZG08_04690 ENOG4105NF4 modulator of drug activity BZG08_04695 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BZG08_04700 ENOG4105E5W Transporter BZG08_04710 ENOG4107RKG DJ-1/PfpI family BZG08_04715 ENOG4105CH6 catalase BZG08_04725 ENOG4105D5Q Arginine ornithine antiporter BZG08_04730 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BZG08_04740 ENOG4105C26 Dehydrogenase BZG08_04760 ENOG4105BZ1 (ABC) transporter BZG08_04780 ENOG4105DRP amino acid AbC transporter BZG08_04785 ENOG4105CDA abc transporter atp-binding protein BZG08_04800 ENOG410839P BZG08_04835 ENOG4107FQX Alpha-acetolactate decarboxylase BZG08_04860 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BZG08_04870 ENOG4105D4P Coproporphyrinogen iii oxidase BZG08_04890 ENOG4105CHH sulfate transporter BZG08_04930 ENOG4106AKK s-layer domain-containing protein BZG08_04940 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BZG08_04945 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BZG08_04965 ENOG4105CGU Enoyl-CoA hydratase BZG08_04985 ENOG4105DER m42 family BZG08_05005 ENOG4105CTU Proline racemase BZG08_05055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BZG08_05070 ENOG4108JQ7 (ABC) transporter BZG08_05080 ENOG4105PKS Excinuclease abc c subunit domain protein BZG08_05115 ENOG4105CSH Transporter BZG08_05125 ENOG4108MRH transcriptional regulatory protein BZG08_05175 ENOG4105CDU Replicative dna helicase BZG08_05225 ENOG4105C0R drug resistance transporter emrb qaca subfamily BZG08_05275 ENOG4107P5I polyketide synthase BZG08_05280 ENOG4108IG5 Transcriptional regulator BZG08_05300 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BZG08_05320 ENOG4105CMT Dihydroxyacetone kinase BZG08_05330 ENOG4105CMT Dihydroxyacetone kinase BZG08_05335 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BZG08_05340 ENOG410847I Transcriptional regulator, BadM Rrf2 family BZG08_05375 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BZG08_05455 ENOG4105WN5 stage II sporulation protein BZG08_05465 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BZG08_05475 ENOG4108MJI response regulator BZG08_05480 ENOG4105BZU Histidine kinase BZG08_05485 ENOG4105BZU Histidine kinase BZG08_05510 ENOG4105K8R UPF0145 protein BZG08_05545 ENOG4107VRP DNA repair exonuclease BZG08_05550 ENOG4106D4I domain protein BZG08_05555 ENOG4105D7V transposase BZG08_05570 ENOG4108IND Tetr family transcriptional regulator BZG08_05575 ENOG4105EQ0 Major Facilitator superfamily BZG08_05600 ENOG4108MUZ hydrolase BZG08_05620 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BZG08_05635 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BZG08_05655 ENOG4105EMN RNA polymerase sigma factor BZG08_05680 ENOG4105C57 major facilitator superfamily BZG08_05685 ENOG4105C0R drug resistance transporter emrb qaca subfamily BZG08_05695 ENOG4105EEM helicase BZG08_05700 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BZG08_05730 ENOG4105K59 histidine triad (HIT) protein BZG08_05770 ENOG410905X membrane-flanked domain protein BZG08_05815 ENOG410905X membrane-flanked domain protein BZG08_05820 ENOG4105CKV Membrane BZG08_05825 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BZG08_05830 ENOG4105BZ4 penicillin-binding protein BZG08_05835 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BZG08_05845 ENOG4105C1Q protoporphyrinogen oxidase BZG08_05870 ENOG4105NA0 Transcriptional regulator BZG08_05885 ENOG4105ECB domain protein BZG08_05915 ENOG4106AXD BZG08_05920 ENOG4108RQ5 Beta-lactamase domain-containing protein BZG08_05925 ENOG4105DF9 Lipoate-protein, ligase BZG08_05940 ENOG4105CEY Amp-dependent synthetase and ligase BZG08_05970 ENOG4105CNA YD repeat protein BZG08_06015 ENOG4105ENX hydrolase BZG08_06025 ENOG4107RN3 metallophosphoesterase BZG08_06030 ENOG4107TVP HD domain protein BZG08_06040 ENOG4108AEY RNA polymerase sigma factor BZG08_06045 ENOG41086D8 Transcriptional regulator BZG08_06070 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BZG08_06095 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BZG08_06100 ENOG4105C8Q Methyl-accepting chemotaxis BZG08_06120 ENOG4105ZU5 s-layer protein BZG08_06125 ENOG4107QP3 malate synthase g BZG08_06140 ENOG4105VEQ Cold shock protein BZG08_06155 ENOG4105XVF Competence transcription factor BZG08_06170 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BZG08_06175 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BZG08_06220 ENOG4105ERH Fumarylacetoacetate hydrolase BZG08_06245 ENOG4105CAQ asparagine synthetase BZG08_06250 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BZG08_06255 ENOG4105CH6 catalase BZG08_06260 ENOG4105BZU Histidine kinase BZG08_06285 ENOG4105QNR S1 RNA binding domain protein BZG08_06295 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BZG08_06305 ENOG4107AYK membrAne BZG08_06310 ENOG41073B9 BZG08_06320 ENOG4108KP7 hydrolase BZG08_06335 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BZG08_06365 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BZG08_06370 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BZG08_06385 ENOG4105C31 Tryptophanyl-tRNA synthetase BZG08_06405 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BZG08_06410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BZG08_06420 ENOG4108JQ7 (ABC) transporter BZG08_06425 ENOG4105UQX Mate efflux family protein BZG08_06450 ENOG4108ZCF integral membrane protein BZG08_06460 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BZG08_06470 ENOG4105DPN Oligoendopeptidase f BZG08_06485 ENOG4108Z18 K06886 hemoglobin BZG08_06490 ENOG4105MIX Adenylate cyclase BZG08_06505 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BZG08_06510 ENOG4105EMS pseudouridine synthase BZG08_06540 ENOG4105K64 Glycosyl transferase, family 2 BZG08_06560 ENOG4107TVC Glycosyl transferase, family 2 BZG08_06580 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BZG08_06585 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BZG08_06595 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BZG08_06645 ENOG4108WVJ 2'-5' rna ligase BZG08_06670 ENOG4105CK7 Sodium proline symporter BZG08_06680 ENOG4105CRQ synthase (Component I) BZG08_06685 ENOG4105DDQ anthranilate synthase BZG08_06780 ENOG4105C7S Dehydrogenase BZG08_06790 ENOG4105VZ8 Transcriptional regulator BZG08_06850 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BZG08_06865 ENOG4105DZ1 carboxypeptidase BZG08_06870 ENOG4105VFR signal peptidase BZG08_06905 ENOG4105C26 Dehydrogenase BZG08_06910 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BZG08_06915 ENOG4105F38 ABC transporter, permease BZG08_06920 ENOG4105D38 putrescine abc transporter BZG08_06925 ENOG4107RUE extracellular solute-binding protein family 1 BZG08_06935 ENOG4105EYF MMPL domain protein BZG08_06945 ENOG4108YBP pseudouridine synthase BZG08_06955 ENOG4105K4I Scp-like extracellular BZG08_06960 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BZG08_06965 ENOG4105CQB FAD linked oxidase domain protein BZG08_06980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZG08_06985 ENOG4105BZU Histidine kinase BZG08_06990 ENOG4105JXH GntR family transcriptional regulator BZG08_07010 ENOG4106A3R peptidase BZG08_07020 ENOG4108QTI )-transporter BZG08_07025 ENOG4107TS3 membrane protein, TerC BZG08_07030 ENOG4105CZN Potassium uptake protein BZG08_07035 ENOG410681C small acid-soluble spore protein BZG08_07040 ENOG4108Z7G MaoC domain protein dehydratase BZG08_07060 ENOG4105CHR reductase BZG08_07070 ENOG4105MWK D-amino acid dehydrogenase, small subunit BZG08_07095 ENOG4105C4Y ABC transporter BZG08_07110 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BZG08_07125 ENOG4105E98 transcriptional regulator DeoR family BZG08_07140 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BZG08_07155 ENOG4105PXI polysaccharide deacetylase BZG08_07165 ENOG4105BZU Histidine kinase BZG08_07170 ENOG41090MY MarR family Transcriptional regulator BZG08_07180 ENOG4106DF1 BZG08_07190 ENOG4105BZU Histidine kinase BZG08_07200 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BZG08_07205 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BZG08_07250 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BZG08_07255 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BZG08_07265 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BZG08_07270 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BZG08_07275 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BZG08_07280 ENOG4105CZV ABC transporter BZG08_07290 ENOG4105CJ1 ABC, transporter BZG08_07330 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BZG08_07335 ENOG4105EA8 2-Nitropropane dioxygenase BZG08_07340 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BZG08_07350 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BZG08_07375 ENOG4105NQC Flavodoxin BZG08_07415 ENOG4107QMU Mate efflux family protein BZG08_07420 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BZG08_07450 ENOG4105CZN Potassium uptake protein BZG08_07455 ENOG41063Y9 BZG08_07460 ENOG4105KBJ sporulation protein ytfj BZG08_07490 ENOG4105CM2 brancheD-chain amino acid aminotransferase BZG08_07495 ENOG4105C7K acetolactate synthase BZG08_07500 ENOG4108ZP8 Acetolactate synthase small subunit BZG08_07505 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BZG08_07515 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BZG08_07540 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BZG08_07575 ENOG4107RVV histidinol phosphate phosphatase, hisj family BZG08_07590 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BZG08_07595 ENOG4105E0M Sulfatase BZG08_07605 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BZG08_07625 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BZG08_07630 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BZG08_07640 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BZG08_07645 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BZG08_07650 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BZG08_07660 ENOG4105C8J )-transporter BZG08_07680 ENOG4105DFD Na H antiporter BZG08_07700 ENOG4105ENE Histidine kinase BZG08_07705 ENOG4105WH1 Two component transcriptional regulator luxr family BZG08_07725 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BZG08_07750 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BZG08_07775 ENOG4105CJ3 phosphate transporter BZG08_07780 ENOG4107GRR phosphate transport regulator BZG08_07785 ENOG4105BZ4 penicillin-binding protein BZG08_07810 ENOG4105I3N Conserved Protein BZG08_07825 ENOG4105BZU Histidine kinase BZG08_07870 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BZG08_07875 ENOG4105DZ1 carboxypeptidase BZG08_07880 ENOG4108JIC nucleoside recognition domain protein BZG08_07890 ENOG4105FE9 pseudouridine synthase BZG08_07900 ENOG4107TWT Cytochrome c biogenesis protein BZG08_07905 ENOG4105CRE cytochrome C BZG08_07910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZG08_07915 ENOG4105BZU Histidine kinase BZG08_07920 ENOG4108WBT adenosyltransferase BZG08_07935 ENOG4108SAX Membrane BZG08_07945 ENOG4105T7X BZG08_07950 ENOG4105C9U ATP-dependent DNA helicase RecQ BZG08_07955 ENOG4105I7S Abortive infection protein BZG08_07970 ENOG4107X2D transcriptional regulator, merr family BZG08_07975 ENOG4108S6Z Negative regulator of genetic competence BZG08_08000 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BZG08_08005 ENOG4105HDK L-asparaginase BZG08_08040 ENOG4105S2F BZG08_08045 ENOG41065D1 BZG08_08075 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BZG08_08090 ENOG4105XXQ heptaprenyl diphosphate synthase component I BZG08_08100 ENOG4105EAH synthase BZG08_08120 ENOG4105CIH Imidazole acetol-phosphate transaminase BZG08_08125 ENOG41068YB TPR repeat-containing protein BZG08_08140 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BZG08_08145 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BZG08_08150 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BZG08_08185 ENOG4108JYZ YitT family BZG08_08195 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BZG08_08210 ENOG4105FJR Lmbe family BZG08_08215 ENOG4105CPK Glycosyl transferase (Group 1 BZG08_08255 ENOG4105DVT helicase BZG08_08260 ENOG4105YAC BZG08_08280 ENOG4105CSM endonuclease III BZG08_08290 ENOG4105BZ4 penicillin-binding protein BZG08_08355 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BZG08_08365 ENOG4105DVT helicase BZG08_08370 ENOG4105CTD carboxy-peptidase BZG08_08385 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BZG08_08395 ENOG4105C2W permease BZG08_08400 ENOG4105DHF Membrane BZG08_08410 ENOG410890F Dynamin family BZG08_08420 ENOG4108W0I acetyltransferase BZG08_08430 ENOG4105KHC sulfurtransferase BZG08_08455 ENOG4106032 Glutathionylspermidine synthase BZG08_08520 ENOG4105CPK Glycosyl transferase (Group 1 BZG08_08535 ENOG4108SZE gCN5-related N-acetyltransferase BZG08_08555 ENOG41081VK Ribonuclease BZG08_08620 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BZG08_08635 ENOG4107RWR Sodium hydrogen exchanger BZG08_08640 ENOG4105CN5 Metallo-Beta-Lactamase BZG08_08645 ENOG4108Z5V transcriptional regulator, merr family BZG08_08655 ENOG4105H67 Protein of unknown function (DUF421) BZG08_08660 ENOG41080C8 DUF218 domain BZG08_08715 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BZG08_08725 ENOG4107R0U MotA TolQ exbB proton channel BZG08_08730 ENOG4105ER2 Ompa motb domain protein BZG08_08735 ENOG4107YTP response regulator receiver protein BZG08_08740 ENOG4105CBS Chea signal transduction histidine kinase BZG08_08745 ENOG4105CBS Chea signal transduction histidine kinase BZG08_08750 ENOG4105DD5 Flagellar motor switch protein BZG08_08765 ENOG4105BZU Histidine kinase BZG08_08785 ENOG4105E1Q flagellar hook-associated protein BZG08_08815 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BZG08_08820 ENOG4108ZC9 flagellar basal-body rod protein flgc BZG08_08825 ENOG41075Z6 flagellar hook-basal body complex protein fliE BZG08_08835 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BZG08_08870 ENOG4105BZE flagellar hook protein, FlgE BZG08_08900 ENOG4105K64 Glycosyl transferase, family 2 BZG08_08960 ENOG4105I03 Flagellin BZG08_08965 ENOG4105E4C Lytic transglycosylase catalytic BZG08_08975 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BZG08_08985 ENOG4105DD5 Flagellar motor switch protein BZG08_08995 ENOG4105CN7 Flagellar biosynthetic protein FliP BZG08_09000 ENOG4105VS8 Flagellar biosynthetic protein fliq BZG08_09010 ENOG4105D00 flagellar biosynthetic protein flhB BZG08_09015 ENOG4105D7B Flagellar biosynthesis protein flha BZG08_09025 ENOG4105KTQ flagellar basal-body rod protein BZG08_09030 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BZG08_09055 ENOG4108RZE Tetr family transcriptional regulator BZG08_09075 ENOG4105KAC Antibiotic biosynthesis monooxygenase BZG08_09100 ENOG4105DUM transcriptional regulator, lysR family BZG08_09110 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BZG08_09115 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BZG08_09120 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BZG08_09160 ENOG4105CVJ phosphoglycerate mutase BZG08_09190 ENOG4105CAQ asparagine synthetase BZG08_09210 ENOG4105PGM cation diffusion facilitator family transporter BZG08_09220 ENOG4105DRR Transcriptional regulator, GntR family BZG08_09225 ENOG4108UZ3 Transporter BZG08_09230 ENOG4105CKI cobalamin synthesis protein BZG08_09240 ENOG4108PJD permease BZG08_09255 ENOG4105DFD Na H antiporter BZG08_09260 ENOG4105C9Q fumarate hydratase class II BZG08_09290 ENOG4105EC3 peptidase S51, dipeptidase E BZG08_09310 ENOG4107QIV Cytochrome c biogenesis protein BZG08_09345 ENOG4106BRA Membrane BZG08_09385 ENOG4105CJ1 ABC, transporter BZG08_09405 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BZG08_09415 ENOG4108IJ0 Aspartate ammonia-lyase BZG08_09420 ENOG4105C6K Malic enzyme BZG08_09495 ENOG4105FVX BZG08_09535 ENOG4105CSR polyphosphate kinase 2 BZG08_09560 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BZG08_09570 ENOG4105EU0 Major facilitator Superfamily BZG08_09575 ENOG4105C6T cysteine synthase BZG08_09595 ENOG4105C8J )-transporter BZG08_09605 ENOG4105X5K response regulator receiver protein BZG08_09610 ENOG4105H67 Protein of unknown function (DUF421) BZG08_09630 ENOG4106KE4 Dehydrogenase BZG08_09650 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BZG08_09655 ENOG4105CHR reductase BZG08_09660 ENOG4105CM2 brancheD-chain amino acid aminotransferase BZG08_09665 ENOG4105C7K acetolactate synthase BZG08_09670 ENOG4108ZP8 Acetolactate synthase small subunit BZG08_09675 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BZG08_09685 ENOG4105C7B Threonine dehydratase BZG08_09710 ENOG4105C6X Major Facilitator BZG08_09715 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BZG08_09725 ENOG4105DY9 regulatoR BZG08_09730 ENOG4105CYC Transferase BZG08_09750 ENOG4105F6J Alpha beta hydrolase fold BZG08_09795 ENOG41068WN BZG08_09820 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BZG08_09825 ENOG4105C72 UPF0176 protein BZG08_09835 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BZG08_09870 ENOG4107RHR regulatoR BZG08_09880 ENOG4105D9N nucleoside BZG08_09885 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BZG08_09920 ENOG4107RAQ aminopeptidase BZG08_09925 ENOG4107STQ Multicopper oxidase BZG08_09970 ENOG4108T5E Copper resistance protein BZG08_09975 ENOG4105KTB nuclear export factor GLE1 BZG08_09985 ENOG4107RT3 EamA-like transporter family BZG08_09990 ENOG4105GZI Transcriptional regulator BZG08_09995 ENOG4108Z40 Transcriptional regulator BZG08_10000 ENOG4107ZXU DSBA oxidoreductase BZG08_10005 ENOG4108TVJ Nitroreductase BZG08_10015 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BZG08_10020 ENOG4106F5Q Membrane BZG08_10025 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BZG08_10035 ENOG4105CKI cobalamin synthesis protein BZG08_10055 ENOG4108Z7G MaoC domain protein dehydratase BZG08_10060 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BZG08_10075 ENOG4105C0Z ABC transporter BZG08_10080 ENOG4108IV0 ABC, transporter BZG08_10085 ENOG4105C32 Amino acid ABC transporter (Permease) BZG08_10095 ENOG4105SKE transcriptional Regulator LysR family BZG08_10115 ENOG4105YGB Transcriptional regulator BZG08_10125 ENOG4105C4M (Ubiquinol oxidase) subunit I BZG08_10130 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BZG08_10135 ENOG4108JJ9 ABC, transporter BZG08_10140 ENOG4108JJ8 (ABC) transporter BZG08_10185 ENOG4105BZ1 (ABC) transporter BZG08_10190 ENOG4105BZ1 (ABC) transporter BZG08_10195 ENOG4105EFI regulatoR BZG08_10200 ENOG4105BZU Histidine kinase BZG08_10220 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BZG08_10225 ENOG4108ZJ4 polysaccharide deacetylase BZG08_10255 ENOG4105D6E homoserine dehydrogenase BZG08_10280 ENOG4108KGH TRANSCRIPTIONal BZG08_10290 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BZG08_10295 ENOG4105BZU Histidine kinase BZG08_10300 ENOG4107VMI polysaccharide deacetylase BZG08_10310 ENOG4105KT7 mgtC SapB transporter BZG08_10315 ENOG4105VRR gCN5-related N-acetyltransferase BZG08_10325 ENOG4105DUU IucA IucC family protein BZG08_10330 ENOG4105CEY Amp-dependent synthetase and ligase BZG08_10345 ENOG4108WBH protein TIM barrel BZG08_10350 ENOG4105YWU small acid-soluble spore protein BZG08_10360 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BZG08_10415 ENOG4105KRN Transcriptional regulator, abrb family BZG08_10425 ENOG4105YVS arsR family transcriptional regulator BZG08_10430 ENOG4107SET aldo keto reductase BZG08_10435 ENOG4107XZQ multidrug resistance protein BZG08_10460 ENOG4105C8Q Methyl-accepting chemotaxis BZG08_10480 ENOG4108K88 Membrane BZG08_10485 ENOG4108WPJ Ferritin-like domain BZG08_10500 ENOG4105DEN Luciferase family BZG08_10520 ENOG4107QM2 Aldo Keto reductase BZG08_10525 ENOG4105CKI cobalamin synthesis protein BZG08_10605 ENOG4105DSE periplasmic solute binding protein BZG08_10615 ENOG4105K4T epimerase BZG08_10625 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BZG08_10650 ENOG4105CVJ phosphoglycerate mutase BZG08_10670 ENOG4107T5V SNARE associated Golgi BZG08_10685 ENOG4108PJD permease BZG08_10695 ENOG4108S4H thioesterase Superfamily protein BZG08_10710 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BZG08_10730 ENOG4105SXS Protein of unknown function (DUF456) BZG08_10735 ENOG4105C37 (CBS) domain BZG08_10755 ENOG4108Z7R Chaperone CsaA BZG08_10775 ENOG4108ZRV stage ii sporulation protein p BZG08_10785 ENOG4108VXD carboxy-peptidase BZG08_10795 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BZG08_10820 ENOG4108X4Q Hydrolase BZG08_10830 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BZG08_10835 ENOG4107RBS Methyltransferase BZG08_10850 ENOG41087PP glycosyltransferase MGT family BZG08_10855 ENOG4108JYZ YitT family BZG08_10860 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BZG08_10890 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BZG08_10950 ENOG4105KBJ sporulation protein ytfj BZG08_10975 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BZG08_10995 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BZG08_11000 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BZG08_11010 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BZG08_11015 ENOG4105EMN RNA polymerase sigma factor BZG08_11040 ENOG4108V06 Glutathione peroxidase BZG08_11055 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BZG08_11075 ENOG4108IUE nitrate reductase beta subunit BZG08_11080 ENOG4105R3A Nitrate reductase BZG08_11105 ENOG4107V6Q Cyclic nucleotide-binding domain BZG08_11110 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BZG08_11115 ENOG4105D06 uba thif-type nad fad binding protein BZG08_11120 ENOG4105CVM Molybdenum cofactor synthesis domain protein BZG08_11125 ENOG4108ZAF Molybdopterin BZG08_11155 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BZG08_11160 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BZG08_11165 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BZG08_11170 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BZG08_11175 ENOG4108IFG nitrite reductase, (NAD(P)H) BZG08_11180 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BZG08_11215 ENOG4105MCT stage V sporulation protein S BZG08_11235 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BZG08_11255 ENOG4105C5H ABC transporter BZG08_11270 ENOG4108UUM single-stranded DNA-binding protein BZG08_11300 ENOG4107YX5 Pfam:DUF548 BZG08_11305 ENOG4105C75 arginyL-tRNA synthetase BZG08_11335 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BZG08_11355 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BZG08_11360 ENOG4105C5S asparaginyl-tRNA synthetase BZG08_11380 ENOG4105EC2 ftsk spoIIIe BZG08_11490 ENOG4105BZW Glycerate kinase BZG08_11495 ENOG4107QPK )-transporter BZG08_11500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZG08_11505 ENOG41062D9 Histidine kinase BZG08_11520 ENOG4105C8J )-transporter BZG08_11540 ENOG4107XGZ Hydrolase BZG08_11545 ENOG4105CY2 Citrate transporter BZG08_11550 ENOG4105C0A alcohol dehydrogenase BZG08_11565 ENOG4105KD7 acetyltransferase BZG08_11595 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BZG08_11615 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BZG08_11630 ENOG4107RVG penicillin-binding protein BZG08_11635 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BZG08_11640 ENOG4105E9Q Acyl-transferase BZG08_11645 ENOG4108UT2 hemolysin iii BZG08_11655 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BZG08_11670 ENOG4108RCR degv family BZG08_11675 ENOG4105E8R UPF0173 metal-dependent hydrolase BZG08_11680 ENOG4108KF3 Electron transport protein SCO1 SenC BZG08_11685 ENOG4107Y70 Heat shock protein BZG08_11690 ENOG4105CAQ asparagine synthetase BZG08_11710 ENOG4108MES Periplasmic binding protein BZG08_11715 ENOG4105F0I Aminotransferase BZG08_11750 ENOG4105D8X mechanosensitive ion channel BZG08_11755 ENOG4105BZU Histidine kinase BZG08_11760 ENOG4105WH1 Two component transcriptional regulator luxr family BZG08_11770 ENOG4106KNT transcriptional regulator BZG08_11790 ENOG4105FQP Beta-lactamase BZG08_11810 ENOG4105CMG Carbohydrate kinase BZG08_11815 ENOG4105CMG Carbohydrate kinase BZG08_11845 ENOG4108IJ8 ABC transporter BZG08_11850 ENOG4105E90 ABC transporter BZG08_11885 ENOG4105C37 (CBS) domain BZG08_11915 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BZG08_11930 ENOG4107S4Y M20 DapE family protein YgeY BZG08_11935 ENOG4108TSC N-acetyltransferase BZG08_11940 ENOG4108JUB Transcriptional regulator BZG08_11950 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BZG08_11990 ENOG4108N23 SpoOM-related protein BZG08_11995 ENOG410841Q phosphoesterase PA-phosphatase related protein BZG08_12005 ENOG4105SZ6 Thioredoxin BZG08_12020 ENOG4108IBT Inherit from COG: transposase BZG08_12155 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BZG08_12195 ENOG4105BZ4 penicillin-binding protein BZG08_12200 ENOG4105CZM Major Facilitator BZG08_12205 ENOG4105W8X HesB YadR YfhF-family protein BZG08_12215 ENOG4105DXD 2-methylcitrate dehydratase BZG08_12220 ENOG4105CR4 methylisocitrate lyase BZG08_12225 ENOG4105C1G acyl-Coa dehydrogenase BZG08_12230 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BZG08_12240 ENOG4105N14 lysine exporter protein LysE YggA BZG08_12245 ENOG4105E39 Enoyl-CoA hydratase BZG08_12260 ENOG4107RFY SbcCD D subunit BZG08_12265 ENOG4105EYH Exonuclease BZG08_12300 ENOG4105FCD Major Facilitator BZG08_12310 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BZG08_12315 ENOG4105E4F Isochorismate synthase BZG08_12320 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BZG08_12325 ENOG4105WQI isochorismatase BZG08_12330 ENOG4105CEY Amp-dependent synthetase and ligase BZG08_12335 ENOG4105WQT MbtH domain protein BZG08_12340 ENOG4105C0R drug resistance transporter emrb qaca subfamily BZG08_12355 ENOG4105K70 DNA-binding protein BZG08_12375 ENOG4105BZG amino acid carrier protein BZG08_12395 ENOG4105FE9 pseudouridine synthase BZG08_12400 ENOG4105C22 threonyL-tRNA synthetase BZG08_12405 ENOG4105C19 ABC transporter BZG08_12425 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BZG08_12450 ENOG4108D32 Methyltransferase BZG08_12480 ENOG41081I9 integral membrane protein BZG08_12495 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BZG08_12505 ENOG4105EYF MMPL domain protein BZG08_12530 ENOG4105WCN acetyltransferase BZG08_12560 ENOG4105C1Q protoporphyrinogen oxidase BZG08_12570 ENOG41068WN BZG08_12580 ENOG4105VEQ Cold shock protein BZG08_12600 ENOG410667J hydrolase BZG08_12645 ENOG4107V2S Transcriptional regulator BZG08_12650 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BZG08_12665 ENOG4105DND Transcriptional regulator BZG08_12670 ENOG4108RPX mosc domain containing protein BZG08_12685 ENOG4105BZ1 (ABC) transporter BZG08_12690 ENOG4105BZ1 (ABC) transporter BZG08_12710 ENOG4108JCI Transcriptional regulator BZG08_12740 ENOG4108KPJ rna polymerase sigma factor BZG08_12770 ENOG4105F32 YngK protein BZG08_12810 ENOG4107STF Involved in phosphonate degradation (By similarity) BZG08_12830 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BZG08_12845 ENOG4105C1J atp-dependent rna helicase BZG08_12860 ENOG4108RZE Tetr family transcriptional regulator BZG08_12880 ENOG41088CC tellurite resistance protein tehB BZG08_12890 ENOG4108I0C methyltransferase BZG08_12895 ENOG4107RA9 decarboxylase BZG08_12900 ENOG41090HR transcriptional regulator BZG08_12950 ENOG4105CIN aminoacyl-histidine dipeptidase BZG08_12985 ENOG4107RF6 penicillin-binding protein BZG08_12990 ENOG4107RF6 penicillin-binding protein BZG08_13000 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BZG08_13005 ENOG4105ETE Transcriptional regulator (LacI family BZG08_13010 ENOG4105IE8 Alpha-ketoglutarate permease BZG08_13015 ENOG4105CK5 oxidoreductase BZG08_13040 ENOG4105D2N Aldolase BZG08_13045 ENOG4105DH8 myo-inositol catabolism BZG08_13075 ENOG4105VZ8 Transcriptional regulator BZG08_13095 ENOG4108VXD carboxy-peptidase BZG08_13115 ENOG41067SE Tetr family transcriptional regulator BZG08_13120 ENOG4105C5H ABC transporter BZG08_13130 ENOG4105BZU Histidine kinase BZG08_13145 ENOG4106ANW SMI1_KNR4 BZG08_13150 ENOG4105CEP NADH dehydrogenase BZG08_13155 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BZG08_13170 ENOG4105CJ1 ABC, transporter BZG08_13180 ENOG4107Z3H Transcriptional regulator, TetR family BZG08_13200 ENOG4105C1G acyl-Coa dehydrogenase BZG08_13205 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BZG08_13210 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BZG08_13215 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BZG08_13220 ENOG4105E39 Enoyl-CoA hydratase BZG08_13225 ENOG4107QX3 carboxylase BZG08_13230 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BZG08_13240 ENOG4105WCN acetyltransferase BZG08_13245 ENOG4105DBI uridine monophosphokinase BZG08_13275 ENOG4105T9C HD domain BZG08_13285 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BZG08_13325 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BZG08_13325 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BZG08_13340 ENOG4105FQP Beta-lactamase BZG08_13350 ENOG4107Y80 Major Facilitator superfamily BZG08_13370 ENOG4105CUV Homoserine Kinase BZG08_13405 ENOG4105CPQ Dehydrogenase BZG08_13525 ENOG4105ETU transcriptional activator (TenA BZG08_13660 ENOG410667J hydrolase BZG08_13670 ENOG4105BZU Histidine kinase BZG08_13675 ENOG4107RF6 penicillin-binding protein BZG08_13695 ENOG4108JJB ABC transporter BZG08_13710 ENOG4108HGU Histidine kinase BZG08_13725 ENOG4105CB2 alcohol dehydrogenase BZG08_13730 ENOG4105CJN penicillin-binding protein BZG08_13740 ENOG4105FQP Beta-lactamase BZG08_13775 ENOG4108V4B ThiJ pfpI BZG08_13815 ENOG4107Y80 Major Facilitator superfamily BZG08_13835 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BZG08_13855 ENOG4107Y9U Membrane BZG08_13895 ENOG4105FCD Major Facilitator BZG08_13910 ENOG4105E09 nadh pyrophosphatase BZG08_13915 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BZG08_13920 ENOG4108Z4K mutator MutT protein BZG08_13955 ENOG4108XI2 Domain of unknown function (DUF1963) BZG08_13990 ENOG4105KWG Pfam:DUF1696 BZG08_14025 ENOG4105PKS Excinuclease abc c subunit domain protein BZG08_14070 ENOG4107VFR oxidoreductase BZG08_14095 ENOG4105PAD Hydrolase BZG08_14115 ENOG4105DY8 decarboxylase BZG08_14130 ENOG4108IUM Glycogen debranching enzyme BZG08_14155 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BZG08_14165 ENOG4105FDR Membrane BZG08_14200 ENOG4108V3A UPF0421 protein BZG08_14220 ENOG4105MSI germination protein ypeb BZG08_14240 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BZG08_14245 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BZG08_14250 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BZG08_14255 ENOG4107Z3H Transcriptional regulator, TetR family BZG08_14290 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BZG08_14310 ENOG4105E98 transcriptional regulator DeoR family BZG08_14335 ENOG41062ES Transcriptional regulator BZG08_14360 ENOG4107QKR Dehydrogenase BZG08_14370 ENOG4107RUY (E1 component), alpha subunit BZG08_14380 ENOG4105E1F short-chain dehydrogenase reductase BZG08_14385 ENOG4105RHY Pfam:UPF0157 BZG08_14420 ENOG4107SQ8 Glycine betaine BZG08_14425 ENOG4108IJ7 Glycine betaine BZG08_14450 ENOG4105E66 phosphoriboisomerase A BZG08_14455 ENOG41082BV acetyltransferase BZG08_14460 ENOG4108M1A Chitin-binding protein BZG08_14505 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BZG08_14555 ENOG4105EEM helicase BZG08_14575 ENOG4105C9U ATP-dependent DNA helicase RecQ BZG08_14630 ENOG4108M1A Chitin-binding protein BZG08_14645 ENOG4105BZG amino acid carrier protein BZG08_14650 ENOG4105C26 Dehydrogenase BZG08_14655 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BZG08_14660 ENOG4105CTU Proline racemase BZG08_14665 ENOG4105CTU Proline racemase BZG08_14670 ENOG41080HI glycine oxidase BZG08_14710 ENOG4107T5V SNARE associated Golgi BZG08_14725 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BZG08_14730 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BZG08_14745 ENOG4105DTQ mandelate racemase muconate lactonizing BZG08_14795 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BZG08_14800 ENOG4105BZU Histidine kinase BZG08_14840 ENOG4105DPN Oligoendopeptidase f BZG08_14855 ENOG4105EPR degv family BZG08_14900 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BZG08_14905 ENOG4106K7D Major facilitator family transporter BZG08_14925 ENOG4107BMA Transglycosylase associated protein BZG08_14940 ENOG41089UC methyltransferase, type 11 BZG08_14980 ENOG4105CHM Aminotransferase BZG08_15060 ENOG4105C02 permease BZG08_15075 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BZG08_15080 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BZG08_15085 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BZG08_15110 ENOG4105E09 nadh pyrophosphatase BZG08_15130 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BZG08_15185 ENOG4107VC0 DNA alkylation repair enzyme BZG08_15200 ENOG4107VMI polysaccharide deacetylase BZG08_15210 ENOG4108ZCF integral membrane protein BZG08_15215 ENOG4105E0M Sulfatase BZG08_15225 ENOG4105C5H ABC transporter BZG08_15240 ENOG4105EYF MMPL domain protein BZG08_15245 ENOG41082JN Transcriptional regulator BZG08_15265 ENOG4105CIH Imidazole acetol-phosphate transaminase BZG08_15270 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BZG08_15280 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BZG08_15330 ENOG41069ER domain protein BZG08_15345 ENOG4105EMN RNA polymerase sigma factor BZG08_15370 ENOG4105D4B ABC, transporter BZG08_15380 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BZG08_15390 ENOG4105DKT Transcriptional regulator BZG08_15405 ENOG41061GT Aldolase BZG08_15425 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BZG08_15455 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BZG08_15465 ENOG4105II7 pyrroline-5-carboxylate reductase BZG08_15475 ENOG4107258 Transcriptional regulator BZG08_15490 ENOG4105E0Y RtcB Protein BZG08_15495 ENOG4105ECK Fatty Acid Desaturase BZG08_15500 ENOG4105G6Z alkaline phosphatase BZG08_15510 ENOG4105VMP Transcriptional regulator BZG08_15525 ENOG41090T1 Membrane BZG08_15535 ENOG4108WCX response regulator BZG08_15545 ENOG41068WN BZG08_15570 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BZG08_15600 ENOG4105CKK Glycosyl transferase, family 2 BZG08_15625 ENOG4105CKK Glycosyl transferase, family 2 BZG08_15635 ENOG4105C8Y Acetylornithine aminotransferase BZG08_15680 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BZG08_15690 ENOG4108TVJ Nitroreductase BZG08_15695 ENOG4105FS7 Transcriptional regulator BZG08_15735 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BZG08_15750 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BZG08_15785 ENOG4108XET gCN5-related N-acetyltransferase BZG08_15870 ENOG410635A Membrane BZG08_15875 ENOG4105KNA -acetyltransferase BZG08_15880 ENOG4108IQI permease BZG08_15890 ENOG4105F1N DNA alkylation repair BZG08_15930 ENOG4107RF6 penicillin-binding protein BZG08_15940 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BZG08_15980 ENOG4105P4J Allophanate hydrolase, subunit 1 BZG08_15985 ENOG4107258 Transcriptional regulator BZG08_15995 ENOG4106N3A copper homeostasis protein cutc BZG08_16005 ENOG4108ZRV stage ii sporulation protein p BZG08_16010 ENOG4108ZHR arsR family transcriptional regulator BZG08_16020 ENOG4105FDT acyl-CoA dehydrogenase BZG08_16040 ENOG4105DWD nucleoside recognition domain protein BZG08_16070 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BZG08_16145 ENOG4105E2A Dehydrogenase BZG08_16160 ENOG4108IJ0 Aspartate ammonia-lyase BZG08_16165 ENOG4105HDK L-asparaginase BZG08_16170 ENOG4108IMY Transcriptional regulator BZG08_16180 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BZG08_16185 ENOG4105CUB amino acid BZG08_16195 ENOG4105II7 pyrroline-5-carboxylate reductase BZG08_16205 ENOG4105C6K Malic enzyme BZG08_16225 ENOG4108Q8B Spore germination protein BZG08_16255 ENOG4105CSV Glutaminase BZG08_16290 ENOG4105CGH 5'-nucleotidase BZG08_16295 ENOG4105CH6 catalase BZG08_16305 ENOG4105CHJ isochorismatase hydrolase BZG08_16340 ENOG41090MY MarR family Transcriptional regulator BZG08_16380 ENOG4108606 TspO/MBR family BZG08_16385 ENOG4105CVP deoxyribo-dipyrimidine photolyase BZG08_16400 ENOG4108TWJ NADH dehydrogenase subunit 5 BZG08_16405 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BZG08_16420 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BZG08_16425 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BZG08_16435 ENOG4105DSE periplasmic solute binding protein BZG08_16440 ENOG4105CC5 ABC transporter BZG08_16445 ENOG4105DIK (ABC) transporter BZG08_16475 ENOG4105D6J arsenicaL-resistance protein BZG08_16480 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BZG08_16485 ENOG41085FC arsR family transcriptional regulator BZG08_16500 ENOG4105F7F Chaperone BZG08_16510 ENOG4105CHR reductase BZG08_16515 ENOG4108YXU transcriptional regulator AsnC family BZG08_16595 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BZG08_16605 ENOG4105C0R drug resistance transporter emrb qaca subfamily BZG08_16620 ENOG4105IIP Membrane BZG08_16635 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZG08_16640 ENOG41062D9 Histidine kinase BZG08_16670 ENOG4105K6H D-cysteine desulfhydrase BZG08_16700 ENOG4105VZ8 Transcriptional regulator BZG08_16715 ENOG4108NNI Beta-lactamase domain-containing protein BZG08_16720 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BZG08_16730 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BZG08_16735 ENOG4105JQZ Methyltransferase BZG08_16750 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BZG08_16755 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BZG08_16775 ENOG4105BZU Histidine kinase BZG08_16790 ENOG4108U05 Transcriptional regulator BZG08_16795 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BZG08_16800 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BZG08_16810 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BZG08_16815 ENOG4105DJB Major Facilitator Superfamily BZG08_16820 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BZG08_16825 ENOG4107QR9 Iron-sulfur cluster binding protein BZG08_16835 ENOG4106P55 Transcriptional regulator BZG08_16845 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BZG08_16885 ENOG4105TRI Hydrolase BZG08_16925 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BZG08_16955 ENOG4107QJQ Mate efflux family protein BZG08_16975 ENOG4105MZU cell filamentation protein BZG08_16980 ENOG4105EQ0 Major Facilitator superfamily BZG08_16985 ENOG4108JGH Tetr family transcriptional regulator BZG08_17000 ENOG4105C44 Serine transporter BZG08_17005 ENOG4105EJQ L-serine dehydratase BZG08_17025 ENOG4108JPW Aminotransferase BZG08_17040 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BZG08_17050 ENOG4105DVH amino acid BZG08_17070 ENOG4108JQ1 Dehydrogenase BZG08_17090 ENOG4108AEY RNA polymerase sigma factor BZG08_17105 ENOG41082W1 Cupin 2, conserved barrel domain protein BZG08_17115 ENOG410874W AraC family transcriptional regulator BZG08_17165 ENOG4108ISG Major Facilitator BZG08_17175 ENOG4107MII Sugar-specific transcriptional regulator TrmB BZG08_17180 ENOG4105CZM Major Facilitator BZG08_17200 ENOG4105DA5 (ABC) transporter BZG08_17205 ENOG41069JR BZG08_17215 ENOG4105RXJ BZG08_17220 ENOG4105KPY Small multidrug resistance protein BZG08_17225 ENOG4105KBX Transcriptional regulator, TetR family BZG08_17240 ENOG4105CRW Short chain fatty acid transporter BZG08_17250 ENOG4105DYS nad(p)h dehydrogenase (quinone) BZG08_17280 ENOG4108JJB ABC transporter BZG08_17285 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BZG08_17310 ENOG4108K8S endonuclease I BZG08_17325 ENOG41067QW Transcriptional regulator BZG08_17335 ENOG4108Z66 YbaK ebsC protein BZG08_17340 ENOG4105CUT histidyl-tRNA synthetase BZG08_17355 ENOG4105KVH Transcriptional regulator BZG08_17360 ENOG4108RCM Nitroreductase BZG08_17385 ENOG4108PSK reductase BZG08_17395 ENOG4105CJ1 ABC, transporter BZG08_17455 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BZG08_17460 ENOG4105DKQ ROK family BZG08_17465 ENOG4106UW1 Major Facilitator superfamily BZG08_17470 ENOG4108UW5 maltose o-acetyltransferase BZG08_17480 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BZG08_17490 ENOG4105C31 Tryptophanyl-tRNA synthetase BZG08_17495 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BZG08_17520 ENOG4105DMQ Methyltransferase BZG08_17530 ENOG4105EV4 Multidrug resistance protein mdtH BZG08_17560 ENOG4105C37 (CBS) domain BZG08_17575 ENOG4105DDN Pentapeptide repeat-containing protein BZG08_17580 ENOG4105XDF Protein of unknown function (DUF1272) BZG08_17585 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BZG08_17590 ENOG4105CMG Carbohydrate kinase BZG08_17595 ENOG4105C6Z Gluconate BZG08_17600 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BZG08_17615 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BZG08_17620 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BZG08_17625 ENOG4105CIS alcohol dehydrogenase BZG08_17630 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BZG08_17650 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BZG08_17655 ENOG4105D4Y metalloprotease BZG08_17675 ENOG4105CV8 reductase BZG08_17680 ENOG4105F27 Major Facilitator BZG08_17700 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BZG08_17705 ENOG4105C44 Serine transporter BZG08_17740 ENOG4105KVH Transcriptional regulator BZG08_17745 ENOG4108TZY GntR Family Transcriptional Regulator BZG08_17755 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BZG08_17765 ENOG4105KVH Transcriptional regulator BZG08_17770 ENOG4105KVH Transcriptional regulator BZG08_17805 ENOG4105JAB phenazine biosynthesis protein, phzf family BZG08_17815 ENOG4105CHR reductase BZG08_17835 ENOG4105KVH Transcriptional regulator BZG08_17860 ENOG4108ZJ4 polysaccharide deacetylase BZG08_17910 ENOG4105KAF membrAne BZG08_17940 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BZG08_17960 ENOG4107YXZ hydrolase, family 25 BZG08_17985 ENOG4105ED2 Beta-lactamase BZG08_17995 ENOG4105H3G oxidoreductase BZG08_18030 ENOG4105CIS alcohol dehydrogenase BZG08_18035 ENOG4105CIS alcohol dehydrogenase BZG08_18075 ENOG4108TN2 lmbE family BZG08_18085 ENOG4107R3E Citrate transporter BZG08_18105 ENOG4108MES Periplasmic binding protein BZG08_18115 ENOG4105EHG Permease protein BZG08_18120 ENOG4105DQ5 transport system permease protein BZG08_18125 ENOG4105NX3 Membrane BZG08_18130 ENOG4107ZY0 Phenazine biosynthesis-like protein BZG08_18150 ENOG4107CUJ Protein of unknown function (DUF2690) BZG08_18160 ENOG4107V2S Transcriptional regulator BZG08_18180 ENOG4105C98 muts2 protein BZG08_18190 ENOG4105E5K Alpha-amylase BZG08_18200 ENOG4105DPN Oligoendopeptidase f BZG08_18205 ENOG4108A04 Beta-lactamase BZG08_18235 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BZG08_18260 ENOG41082BM Transcriptional regulator, arsr family BZG08_18265 ENOG4105CIS alcohol dehydrogenase BZG08_18290 ENOG4105RHY Pfam:UPF0157 BZG08_18300 ENOG4105C09 Bile acid BZG08_18305 ENOG4105CQB FAD linked oxidase domain protein BZG08_18335 ENOG4108UT6 Transferase hexapeptide repeat containing protein BZG08_18345 ENOG4105K64 Glycosyl transferase, family 2 BZG08_18350 ENOG4105E39 Enoyl-CoA hydratase BZG08_18360 ENOG4105KT7 mgtC SapB transporter BZG08_18375 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BZG08_18380 ENOG41073R8 VanW family BZG08_18390 ENOG4108R1P BZG08_18410 ENOG4105VEQ Cold shock protein BZG08_18430 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BZG08_18450 ENOG410904N short-chain dehydrogenase reductase BZG08_18460 ENOG4106IQC argininosuccinate lyase BZG08_18475 ENOG4108IA2 Sodium pantothenate symporter BZG08_18480 ENOG4105RG0 Membrane BZG08_18485 ENOG4105C26 Dehydrogenase BZG08_18490 ENOG4105CHR reductase BZG08_18500 ENOG4105EWU Squalene--hopene cyclase BZG08_18510 ENOG4105FR1 rard protein BZG08_18515 ENOG410696E Membrane BZG08_18530 ENOG4105D1F ATP-binding protein BZG08_18540 ENOG4108ZAF Molybdopterin BZG08_18545 ENOG4105CVM Molybdenum cofactor synthesis domain protein BZG08_18550 ENOG4105D06 uba thif-type nad fad binding protein BZG08_18555 ENOG4105TMB Formate nitrite transporter BZG08_18570 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BZG08_18575 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BZG08_18585 ENOG4108JB9 formate dehydrogenase BZG08_18595 ENOG4105E1K spore germination protein BZG08_18655 ENOG4107QJT sodium dicarboxylate symporter BZG08_18660 ENOG4108KGH TRANSCRIPTIONal BZG08_18670 ENOG4105EMN RNA polymerase sigma factor BZG08_18695 ENOG4105CIG ABC transporter BZG08_18705 ENOG4105D9R oxidoreductase BZG08_18715 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BZG08_18725 ENOG4105K4P CoA-binding domain protein BZG08_18730 ENOG4105C0H protease BZG08_18735 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZG08_18745 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BZG08_18750 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BZG08_18755 ENOG4105W8X HesB YadR YfhF-family protein BZG08_18785 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BZG08_18795 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BZG08_18805 ENOG4108JJA ABC, transporter BZG08_18810 ENOG4108I0Z Aconitate hydratase BZG08_18840 ENOG4105E5W Transporter BZG08_18850 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BZG08_18870 ENOG4107F3J Amp-dependent synthetase and ligase BZG08_18875 ENOG4107ZYJ bioY protein BZG08_18880 ENOG4105CEY Amp-dependent synthetase and ligase BZG08_18935 ENOG4107AYK membrAne BZG08_18950 ENOG4105BZU Histidine kinase BZG08_18955 ENOG4105FBA Phospholipase Carboxylesterase BZG08_18960 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BZG08_18965 ENOG4105CK7 Sodium proline symporter BZG08_18970 ENOG4105CBC glutamate synthase BZG08_18975 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BZG08_18980 ENOG4108VJ1 Transcriptional regulator (CarD family BZG08_18985 ENOG4108903 Formimidoylglutamase BZG08_19010 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BZG08_19075 ENOG4107QIV Cytochrome c biogenesis protein BZG08_19090 ENOG4107RSM transcriptional regulator BZG08_19095 ENOG4105VAW lrga family BZG08_19100 ENOG41067MG lrgb family BZG08_19125 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BZG08_19140 ENOG4105BZ1 (ABC) transporter BZG08_19145 ENOG4105BZ1 (ABC) transporter BZG08_19170 ENOG4105D7V transposase BZG08_19190 ENOG4105D5T phosphonate abc transporter BZG08_19210 ENOG4108SVB resolvase BZG08_19230 ENOG4105K7K Transcriptional regulator BZG08_19275 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BZG08_19280 ENOG4105XSJ toxin secretion phage lysis holin BZG08_19485 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BZG08_19600 ENOG4105C5F glutamine synthetase BZG08_19605 ENOG4105KV4 Transcriptional regulator BZG08_19610 ENOG4105CXI aluminum resistance protein BZG08_19620 ENOG4105EN6 Membrane BZG08_19630 ENOG4106F1P AAA ATPase, central domain protein BZG08_19660 ENOG41069ER domain protein BZG08_19665 ENOG4105DM4 PTS System BZG08_19670 ENOG4105DE4 1-phosphofructokinase BZG08_19675 ENOG4105E98 transcriptional regulator DeoR family BZG08_19685 ENOG4108SJC Membrane BZG08_19700 ENOG4105C85 amino acid BZG08_19730 ENOG4105TMB Formate nitrite transporter BZG08_19735 ENOG4105K70 DNA-binding protein BZG08_19745 ENOG4105C59 p-type ATPase BZG08_19750 ENOG410681U heavy metal transport detoxification protein BZG08_19755 ENOG4105VPX protein, conserved in bacteria BZG08_19765 ENOG4105NIV Esterase BZG08_19770 ENOG4105E0A ABC, transporter BZG08_19790 ENOG4105CGK Exodeoxyribonuclease III BZG08_19800 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BZG08_19805 ENOG4105D03 DNA-3-methyladenine glycosylase II BZG08_19835 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BZG08_19840 ENOG4105BZU Histidine kinase BZG08_19860 ENOG41067MG lrgb family BZG08_19875 ENOG4107TTQ Alpha beta hydrolase fold BZG08_19880 ENOG4107YEI lmbE family BZG08_19905 ENOG4105F0V Cell wall hydrolase BZG08_19910 ENOG4107R6R udp-galactopyranose mutase BZG08_19915 ENOG4105E0M Sulfatase BZG08_19920 ENOG410890F Dynamin family BZG08_19930 ENOG4107QHE Choloylglycine hydrolase BZG08_19955 ENOG4105DA5 (ABC) transporter BZG08_19980 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BZG08_19985 ENOG4105DQU oxidoreductase, subunit beta BZG08_19990 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BZG08_19995 ENOG4108IGT Dipeptidase BZG08_20000 ENOG4105MCT stage V sporulation protein S BZG08_20005 ENOG4105D48 metallophosphoesterase BZG08_20030 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BZG08_20045 ENOG4105XZV Protein of unknown function (DUF3243) BZG08_20050 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BZG08_20070 ENOG4105UIB (ABC) transporter BZG08_20075 ENOG4105UIB (ABC) transporter BZG08_20080 ENOG4108JQ9 ABC transporter BZG08_20085 ENOG4105DIH basic membrane BZG08_20090 ENOG4105FDP GntR family transcriptional regulator BZG08_20095 ENOG4107QZI cell division protein FtsK BZG08_20105 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BZG08_20120 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BZG08_20130 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BZG08_20135 ENOG4108S0H Dipicolinic acid synthetase, b subunit BZG08_20140 ENOG4105E35 Dipicolinate synthase subunit A BZG08_20155 ENOG4105C1V Peptidase, M16 BZG08_20175 ENOG4105DTN riboflavin biosynthesis protein ribF BZG08_20180 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BZG08_20190 ENOG4105W7A Protein of unknown function (DUF503) BZG08_20200 ENOG4105VHM ribosomal protein BZG08_20205 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BZG08_20210 ENOG4105CHV Transcription elongation factor NusA BZG08_20220 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BZG08_20235 ENOG4105DZP Membrane-associated zinc metalloprotease BZG08_20240 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BZG08_20245 ENOG4105KNE Phosphatidate cytidylyltransferase BZG08_20250 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BZG08_20290 ENOG4108HE4 integrase family BZG08_20300 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BZG08_20310 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BZG08_20325 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BZG08_20350 ENOG4105VB6 UPF0109 protein BZG08_20370 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BZG08_20375 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BZG08_20390 ENOG4105CHR reductase BZG08_20395 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BZG08_20410 ENOG4105CB5 ATP-dependent DNA helicase recG BZG08_20415 ENOG4105DP4 dak2 domain fusion protein ylov BZG08_20420 ENOG4108ZAA Alkaline-shock protein BZG08_20435 ENOG4105FJ0 thiamine BZG08_20440 ENOG4105DJV ribulose-phosphate 3-epimerase BZG08_20445 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BZG08_20450 ENOG4105D9P serine threonine protein kinase BZG08_20455 ENOG4108ZF3 Phosphatase BZG08_20465 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BZG08_20475 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BZG08_20480 ENOG4105C25 Primosomal protein n' BZG08_20485 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BZG08_20505 ENOG4105DSJ YicC domain protein BZG08_20515 ENOG4105F23 Fibronectin-binding protein BZG08_20520 ENOG4105DC7 peptidase M24 BZG08_20580 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BZG08_20605 ENOG4105C34 Pseudouridine synthase BZG08_20620 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BZG08_20630 ENOG4105DBK s4 domain protein BZG08_20635 ENOG41067XK integral membrane protein BZG08_20645 ENOG4105DFA alanine racemase domain protein BZG08_20650 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BZG08_20655 ENOG4105WR5 sporulation protein, YlmC YmxH family BZG08_20665 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BZG08_20675 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BZG08_20680 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BZG08_20685 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BZG08_20690 ENOG4105D4A Cell wall formation (By similarity) BZG08_20695 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BZG08_20700 ENOG4105CNI cell division protein FtsW BZG08_20715 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BZG08_20720 ENOG4105CJN penicillin-binding protein BZG08_20725 ENOG4105CJN penicillin-binding protein BZG08_20730 ENOG41068DC Essential cell division protein (By similarity) BZG08_20765 ENOG4105KNH Nucleic acid-binding protein BZG08_20815 ENOG4105XSJ toxin secretion phage lysis holin BZG08_20895 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BZG08_20905 ENOG4105CAR Terminase, large subunit BZG08_21010 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BZG08_21025 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BZG08_21080 ENOG4108IMY Transcriptional regulator BZG08_21115 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BZG08_21125 ENOG41063PX domain protein BZG08_21130 ENOG4105D78 K07001 NTE family protein BZG08_21135 ENOG4105H20 Sporulation integral membrane protein YlbJ BZG08_21145 ENOG4106H78 methyltransferase BZG08_21165 ENOG4107TB6 phosphoglycerate mutase BZG08_21180 ENOG4106UY4 Inherit from COG: Scp-like extracellular BZG08_21230 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BZG08_21240 ENOG4105CNI cell division protein FtsW BZG08_21255 ENOG4108IAB Phoh family BZG08_21275 ENOG4105QA2 BZG08_21280 ENOG4105CI3 gtp-binding protein typa BZG08_21290 ENOG4105ECY inositol monophosphatase BZG08_21310 ENOG4105CXN decarboxylase BZG08_21355 ENOG4105C7S Dehydrogenase BZG08_21360 ENOG4105CPP Dehydrogenase, E1 component BZG08_21375 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BZG08_21380 ENOG4108X4Q Hydrolase BZG08_21395 ENOG4105CN5 Metallo-Beta-Lactamase BZG08_21400 ENOG4107ZYR domain protein BZG08_21435 ENOG4108XRC Protein of unknown function (DUF458) BZG08_21445 ENOG4107IN1 Protein of unknown function (DUF1797) BZG08_21460 ENOG4105EPM Diguanylate phosphodiesterase BZG08_21465 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BZG08_21485 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BZG08_21495 ENOG4105UIN BZG08_21560 ENOG4108HGU Histidine kinase BZG08_21570 ENOG4105CHM Aminotransferase BZG08_21575 ENOG4105FKQ transcriptional regulator BZG08_21580 ENOG4105EG2 ABC transporter, permease BZG08_21590 ENOG4107FKK extracellular solute-binding protein family 1 BZG08_21600 ENOG4105CG3 alpha amylase, catalytic region BZG08_21645 ENOG4105CHU acetyl-coa acetyltransferase BZG08_21685 ENOG4105K7K Transcriptional regulator BZG08_21690 ENOG4105DTD Dehydrogenase BZG08_21700 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BZG08_21710 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BZG08_21735 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BZG08_21760 ENOG4106TD9 Diguanylate cyclase BZG08_21780 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BZG08_21795 ENOG4105CID antiterminator BZG08_21805 ENOG4105FDP GntR family transcriptional regulator BZG08_21815 ENOG4105CE4 GlcNAc 6-P deacetylase BZG08_21860 ENOG4107ZE5 PPIases accelerate the folding of proteins BZG08_21865 ENOG4105PTM secreted protein BZG08_21870 ENOG4105J7I hydrolase BZG08_21880 ENOG4105G6R Stage v sporulation protein ae BZG08_21890 ENOG4105CZ3 stage V sporulation protein ad BZG08_21895 ENOG41090VF Stage v sporulation protein ac BZG08_21915 ENOG4105C8J )-transporter BZG08_21920 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BZG08_21930 ENOG41082AN stage II sporulation protein BZG08_21935 ENOG4105DZ1 carboxypeptidase BZG08_21945 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BZG08_21950 ENOG4105DVE abc transporter atp-binding protein BZG08_21985 ENOG4105D7N magnesium and cobalt transport protein CorA BZG08_22010 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BZG08_22020 ENOG4105I3K Ferric uptake regulator, Fur family BZG08_22025 ENOG4105MZ9 stage II sporulation protein m BZG08_22045 ENOG4105CPC Aldo Keto reductase BZG08_22055 ENOG4105RHY Pfam:UPF0157 BZG08_22075 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BZG08_22085 ENOG4105ETE Transcriptional regulator (LacI family BZG08_22090 ENOG4108YM7 Gcn5-related n-acetyltransferase BZG08_22110 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BZG08_22115 ENOG4108R6K riboflavin synthase, subunit alpha BZG08_22135 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BZG08_22140 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BZG08_22145 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BZG08_22150 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BZG08_22160 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BZG08_22175 ENOG4105DFD Na H antiporter BZG08_22180 ENOG4105CGH 5'-nucleotidase BZG08_22220 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BZG08_22235 ENOG4108IXY short-chain dehydrogenase reductase BZG08_22245 ENOG4105II7 pyrroline-5-carboxylate reductase BZG08_22250 ENOG4105EJQ L-serine dehydratase BZG08_22280 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BZG08_22290 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BZG08_22295 ENOG4105D9U N-acetyltransferase BZG08_22310 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BZG08_22315 ENOG4108QEG Membrane BZG08_22320 ENOG4105CDA abc transporter atp-binding protein BZG08_22325 ENOG4105E5Q amino acid AbC transporter BZG08_22330 ENOG4108HW3 (ABC) transporter BZG08_22345 ENOG4105G7B Protein of unknown function (DUF2992) BZG08_22350 ENOG4105E09 nadh pyrophosphatase BZG08_22365 ENOG4105C7S Dehydrogenase BZG08_22370 ENOG4105CPP Dehydrogenase, E1 component BZG08_22390 ENOG4107RDP Dehydrogenase BZG08_22405 ENOG4108JUB Transcriptional regulator BZG08_22415 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BZG08_22430 ENOG4107QQR Sporulation BZG08_22440 ENOG4105S1Z Stage IV sporulation protein B BZG08_22445 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BZG08_22455 ENOG4105DX0 Hemolysin A BZG08_22465 ENOG4105CTB Polyprenyl synthetase BZG08_22490 ENOG4108ZSR alkaline shock protein BZG08_22495 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BZG08_22520 ENOG410644B Stage III sporulation protein af BZG08_22530 ENOG4105KQ4 Stage iii sporulation protein ad BZG08_22535 ENOG4108CQH stage III sporulation protein AC BZG08_22540 ENOG4105KR5 Stage iii sporulation protein BZG08_22545 ENOG4105CD2 stage iii sporulation protein aa BZG08_22570 ENOG4105DC7 peptidase M24 BZG08_22585 ENOG4105CBJ Metal-dependent enzyme BZG08_22595 ENOG4107YBY Hydrolase BZG08_22615 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BZG08_22620 ENOG4105WZW rhodanese family BZG08_22640 ENOG41080TC multidrug resistance protein BZG08_22680 ENOG4105CJ1 ABC, transporter BZG08_22685 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BZG08_22720 ENOG4105C0D helicase BZG08_22845 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BZG08_22850 ENOG4105C3R Methionine synthase BZG08_22860 ENOG4105C28 cystathionine BZG08_22865 ENOG4105C28 cystathionine BZG08_22885 ENOG4105C5X domain protein BZG08_22895 ENOG4105DKQ ROK family BZG08_22905 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BZG08_22920 ENOG4108UTW Plays a role in the regulation of phosphate uptake BZG08_22925 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BZG08_22930 ENOG4105E2Z phosphate ABC transporter (Permease BZG08_22935 ENOG4105C8U phosphate abc transporter BZG08_22940 ENOG4105PWN phosphate abc transporter BZG08_22945 ENOG4107RF6 penicillin-binding protein BZG08_22955 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BZG08_22980 ENOG4105N80 Ferric uptake regulator, Fur family BZG08_22990 ENOG4105FDK ABC transporter BZG08_22995 ENOG4108JYZ YitT family BZG08_23000 ENOG41069ZM Protein of unknown function (DUF2624) BZG08_23025 ENOG4105EGD dinuclear metal center protein, YbgI family BZG08_23040 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BZG08_23045 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BZG08_23085 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BZG08_23090 ENOG4105KG3 cytidine deaminase BZG08_23095 ENOG4107YR5 Diacylglycerol kinase BZG08_23105 ENOG4105CTJ Metal Dependent Phosphohydrolase BZG08_23110 ENOG4105C9A Phoh family BZG08_23125 ENOG41068P3 sporulation protein YqfC BZG08_23130 ENOG4105KTH gatB Yqey BZG08_23145 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BZG08_23150 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BZG08_23170 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BZG08_23180 ENOG4105CSA Coproporphyrinogen iii oxidase BZG08_23185 ENOG4105KVH Transcriptional regulator BZG08_23210 ENOG4105TQK DNA polymerase iii, delta' subunit BZG08_23220 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BZG08_23225 ENOG4108UK2 deaminase BZG08_23230 ENOG4105KQC Competence protein BZG08_23240 ENOG4105DXX methyltransferase BZG08_23250 ENOG4108WF2 Metal Dependent Phosphohydrolase BZG08_23260 ENOG410812S Rna-binding protein BZG08_23270 ENOG4105CQW ribosome biogenesis GTPase YqeH BZG08_23275 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BZG08_23290 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BZG08_23315 ENOG4108TVJ Nitroreductase BZG08_23330 ENOG4105G6Z alkaline phosphatase BZG08_23340 ENOG4108MUZ hydrolase BZG08_23375 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BZG08_23380 ENOG4105MIR Phenylalanine 4-monooxygenase BZG08_23430 ENOG4105S6R Iron-hydroxamate transporter permease subunit BZG08_23435 ENOG4108V5C ABC transporter BZG08_23450 ENOG4108EKI Dehydrogenase BZG08_23455 ENOG4105C28 cystathionine BZG08_23485 ENOG4107XRG penicillin-binding protein BZG08_23500 ENOG4105CFP Peptidase U32 BZG08_23505 ENOG4105XYU peptidase (U32 family) BZG08_23510 ENOG4108VQJ O-methyltransferase BZG08_23515 ENOG4105HHA aminodeoxychorismate lyase BZG08_23535 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BZG08_23545 ENOG4105C02 permease BZG08_23560 ENOG41060CR BZG08_23565 ENOG4105C7H Helicase, RecD TraA family BZG08_23575 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BZG08_23580 ENOG4105C3J Cysteine desulfurase BZG08_23590 ENOG4105D1H recombination factor protein RarA BZG08_23595 ENOG4108VCI transcription factor, rsfa family BZG08_23600 ENOG4105CUZ uba thif-type nad fad binding protein BZG08_23610 ENOG4105CUT histidyl-tRNA synthetase BZG08_23630 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BZG08_23640 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BZG08_23645 ENOG41076HS cation diffusion facilitator family transporter BZG08_23650 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BZG08_23660 ENOG4105CKP Polysaccharide Biosynthesis Protein BZG08_23665 ENOG4108QG2 Membrane BZG08_23675 ENOG4105VIE preprotein translocase, subunit YajC BZG08_23690 ENOG41061AI Protein of unknown function (DUF2905) BZG08_23705 ENOG4108HUF Transporter BZG08_23715 ENOG4108IPJ Membrane BZG08_23720 ENOG4108IPJ Membrane BZG08_23725 ENOG41082BM Transcriptional regulator, arsr family BZG08_23750 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BZG08_23755 ENOG4108IYU L-aspartate oxidase BZG08_23770 ENOG4108RPX mosc domain containing protein BZG08_23775 ENOG4105CQC Prephenate dehydratase BZG08_23805 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BZG08_23820 ENOG4105X36 (ribosomal) protein BZG08_23830 ENOG4105C03 ribonuclease BZG08_23845 ENOG4107QMS site-determining protein BZG08_23860 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BZG08_23865 ENOG4105DFF Rod shape-determining protein mreb BZG08_23890 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BZG08_23895 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BZG08_23905 ENOG41068KH stage VI sporulation protein D BZG08_23915 ENOG4105D52 delta-aminolevulinic acid dehydratase BZG08_23940 ENOG4105K56 Transcriptional regulator BZG08_23960 ENOG4108IUQ atp-dependent protease BZG08_23990 ENOG4108QCI YvbH-like oligomerisation region BZG08_24015 ENOG4105M59 Phosphodiesterase, mj0936 family BZG08_24020 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BZG08_24030 ENOG4108XJQ germination protein BZG08_24040 ENOG4108PCX Major Facilitator BZG08_24050 ENOG4105KBX Transcriptional regulator, TetR family BZG08_24065 ENOG4105PFC Transcriptional regulator BZG08_24080 ENOG4105DZC cytosine deaminase BZG08_24085 ENOG4105DZC cytosine deaminase BZG08_24090 ENOG4105DEF Extracellular solute-binding protein, family 5 BZG08_24095 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BZG08_24110 ENOG4108JQ7 (ABC) transporter BZG08_24120 ENOG4105DY9 regulatoR BZG08_24135 ENOG41067S9 phage shock protein C, PspC BZG08_24140 ENOG4108JCI Transcriptional regulator BZG08_24150 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BZG08_24155 ENOG4108Z40 Transcriptional regulator BZG08_24160 ENOG4105RHA ABC transporter, permease BZG08_24165 ENOG4108IUX (ABC) transporter BZG08_24170 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BZG08_24175 ENOG4105ER2 Ompa motb domain protein BZG08_24180 ENOG4105ER2 Ompa motb domain protein BZG08_24185 ENOG4105E14 MotA TolQ exbB proton channel BZG08_24190 ENOG4108VXD carboxy-peptidase BZG08_24200 ENOG4105E33 succinate dehydrogenase BZG08_24210 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BZG08_24225 ENOG4105K63 Thioredoxin BZG08_24230 ENOG4105C10 Electron transfer flavoprotein BZG08_24235 ENOG4105BZJ Electron transfer flavoprotein BZG08_24240 ENOG41060WC Enoyl-CoA hydratase BZG08_24245 ENOG4107Z3H Transcriptional regulator, TetR family BZG08_24250 ENOG4105CEY Amp-dependent synthetase and ligase BZG08_24265 ENOG4105J76 Periplasmic binding protein BZG08_24270 ENOG4105S6R Iron-hydroxamate transporter permease subunit BZG08_24315 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BZG08_24330 ENOG4105DR4 Methyltransferase BZG08_24345 ENOG4105KFN sortase, SrtB family BZG08_24350 ENOG4105E0A ABC, transporter BZG08_24365 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BZG08_24375 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BZG08_24385 ENOG4105FE9 pseudouridine synthase BZG08_24400 ENOG4105DCG PHP domain protein BZG08_24435 ENOG4105C5S asparaginyl-tRNA synthetase BZG08_24440 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BZG08_24450 ENOG4108RWN rrna methyltransferase BZG08_24485 ENOG4105C0R drug resistance transporter emrb qaca subfamily BZG08_24490 ENOG4105CW7 secretion protein, HlyD family BZG08_24495 ENOG4108JGH Tetr family transcriptional regulator BZG08_24500 ENOG4105CN9 Peptidase m42 family protein BZG08_24520 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BZG08_24525 ENOG4105C22 threonyL-tRNA synthetase BZG08_24530 ENOG4108TDW sporulation protein YtxC BZG08_24550 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BZG08_24560 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BZG08_24565 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BZG08_24575 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BZG08_24580 ENOG4105C2M dna polymerase I BZG08_24585 ENOG4105BZU Histidine kinase BZG08_24590 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BZG08_24615 ENOG4108HMX isocitrate dehydrogenase (NADP) BZG08_24620 ENOG4105BZN citrate synthase BZG08_24635 ENOG4108REF Sporulation integral membrane protein ytvi BZG08_24640 ENOG4105FS0 cytoplasmic membrane protein BZG08_24665 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BZG08_24670 ENOG4105C6K Malic enzyme BZG08_24675 ENOG4105C0B DNA polymerase III (alpha subunit) BZG08_24680 ENOG4105VV2 BZG08_24690 ENOG4105SFS phosphoesterase RecJ domain protein BZG08_24730 ENOG4105DC7 peptidase M24 BZG08_24770 ENOG4105Z7P Acetyltransferase (GNAT) family BZG08_24775 ENOG41082W1 Cupin 2, conserved barrel domain protein BZG08_24785 ENOG4105VZ8 Transcriptional regulator BZG08_24805 ENOG4107YZX Universal stress protein BZG08_24855 ENOG4108JYZ YitT family BZG08_24875 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BZG08_24885 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BZG08_24890 ENOG4105KBJ sporulation protein ytfj BZG08_24905 ENOG4105EFZ amidohydrolase BZG08_24915 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BZG08_24940 ENOG4106KR7 LysR family Transcriptional regulator BZG08_24960 ENOG4105C28 cystathionine BZG08_24985 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BZG08_24995 ENOG4105EMN RNA polymerase sigma factor BZG08_25010 ENOG4105F1V Acetoin utilization protein BZG08_25015 ENOG4105W87 Cbs domain BZG08_25020 ENOG4105DGU Histone deacetylase BZG08_25035 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BZG08_25045 ENOG4107SNB ankyrin repeat protein YahD BZG08_25050 ENOG4105EP9 oxidoreductase BZG08_25080 ENOG4105ETE Transcriptional regulator (LacI family BZG08_25105 ENOG4105C88 aminopeptidase BZG08_25150 ENOG4108VDD TRNA binding domain protein BZG08_25180 ENOG4105C8F Beta-lactamase domain protein BZG08_25195 ENOG4108V15 phosphotransferase enzyme family BZG08_25200 ENOG4108IUM Glycogen debranching enzyme BZG08_25215 ENOG4107QSE Dipeptidase BZG08_25220 ENOG4107QSE Dipeptidase BZG08_25225 ENOG4105YW5 deoR family transcriptional regulator BZG08_25240 ENOG4105CBX hi0933 family BZG08_25285 ENOG4108VJ1 Transcriptional regulator (CarD family BZG08_25290 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BZG08_25295 ENOG4105CSC Glucose uptake protein BZG08_25310 ENOG4108ZAF Molybdopterin BZG08_25315 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BZG08_25320 ENOG4105CVM Molybdenum cofactor synthesis domain protein BZG08_25330 ENOG4105D06 uba thif-type nad fad binding protein BZG08_25355 ENOG41085GJ domain protein BZG08_25365 ENOG4105DWV Homoserine O-trans-acetylase BZG08_25375 ENOG4108B31 Spore germination protein BZG08_25410 ENOG410605W Major Facilitator BZG08_25415 ENOG4107S91 Sodium hydrogen exchanger BZG08_25420 ENOG4105NCW Trka-c domain protein BZG08_25435 ENOG4105C19 ABC transporter BZG08_25455 ENOG4105N5T Radical SAM Protein BZG08_25465 ENOG4105DA5 (ABC) transporter BZG08_25495 ENOG4105E8V Alpha Beta Hydrolase Fold protein BZG08_25500 ENOG4108Z0R Transferase BZG08_25505 ENOG4105YVM Phosphoesterase, PA-phosphatase related BZG08_25510 ENOG4105BZF Glycosyl transferase (Group 1 BZG08_25520 ENOG4108RIR Molybdenum cofactor biosynthesis protein BZG08_25580 ENOG4105EGD dinuclear metal center protein, YbgI family BZG08_25585 ENOG4105BZU Histidine kinase BZG08_25590 ENOG4105BZU Histidine kinase BZG08_25595 ENOG4107S9D Alpha beta hydrolase BZG08_25600 ENOG4107T7U Sulfatase BZG08_25620 ENOG4105D2X ABC transporter substrate-binding protein BZG08_25630 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BZG08_25650 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BZG08_25695 ENOG4108V2W Carbonate dehydratase BZG08_25700 ENOG4105C4M (Ubiquinol oxidase) subunit I BZG08_25705 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BZG08_25755 ENOG41087YS Phage shock protein A BZG08_25790 ENOG4105BZU Histidine kinase BZG08_25795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZG08_25820 ENOG4108UGV hypoxanthine phosphoribosyltransferase BZG08_25830 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BZG08_25865 ENOG4107ZTW SNARE associated Golgi BZG08_25880 ENOG4105C19 ABC transporter BZG08_25885 ENOG41086D8 Transcriptional regulator BZG08_25925 ENOG4105C6Z Gluconate BZG08_25930 ENOG4105FDP GntR family transcriptional regulator BZG08_25950 ENOG41069H0 dihydroorotase EC 3.5.2.3 BZG08_25980 ENOG4105DTQ mandelate racemase muconate lactonizing BZG08_25990 ENOG4108IPT Naphthoate synthase BZG08_25995 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BZG08_26000 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BZG08_26005 ENOG4105E4F Isochorismate synthase BZG08_26010 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BZG08_26020 ENOG4105VEQ Cold shock protein BZG08_26045 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BZG08_26055 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BZG08_26080 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BZG08_26180 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BZG08_26225 ENOG4105KT7 mgtC SapB transporter BZG08_26230 ENOG4107PBV potassium channel BZG08_26240 ENOG4107QYV phosphohexose isomerase BZG08_26250 ENOG4105WG9 Conserved Protein BZG08_26260 ENOG4105CHM Aminotransferase BZG08_26265 ENOG4108ZB6 transcriptional regulator AsnC family BZG08_26270 ENOG4105C5I Dehydrogenase BZG08_26275 ENOG4108MUZ hydrolase BZG08_26285 ENOG4105C87 Aminotransferase class I and II BZG08_26300 ENOG4105Y38 Kinase-associated protein B BZG08_26310 ENOG4107R3E Citrate transporter BZG08_26330 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BZG08_26335 ENOG4105KA0 thioesterase Superfamily protein BZG08_26375 ENOG41069ER domain protein BZG08_26390 ENOG4105CEP NADH dehydrogenase BZG08_26420 ENOG4105EWC Purine nucleoside phosphorylase BZG08_26440 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BZG08_26465 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BZG08_26470 ENOG4105C4B ABC transporter, permease BZG08_26480 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BZG08_26525 ENOG41083MR nifu domain-containing protein BZG08_26540 ENOG4108W5N phosphatidylglycerophosphatase a BZG08_26550 ENOG4105DYS nad(p)h dehydrogenase (quinone) BZG08_26555 ENOG4105D4U had-superfamily hydrolase, subfamily iia BZG08_26570 ENOG4105CBT Fructose-1,6-bisphosphatase BZG08_26590 ENOG4105MMD transcriptional regulator BZG08_26595 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BZG08_26600 ENOG4107TXC Transcriptional regulator BZG08_26605 ENOG41090T1 Membrane BZG08_26630 ENOG4105FAA peptidase M23 BZG08_26640 ENOG4105KZD Domain of unknown function (DUF1805) BZG08_26645 ENOG4107R8B 5'-nucleotidase BZG08_26665 ENOG4105DIW FeS assembly protein SUFB BZG08_26670 ENOG4108UNV SUF system FeS assembly protein, NifU family BZG08_26675 ENOG4105C9B Cysteine desulfurase BZG08_26680 ENOG4105JRK feS assembly protein SufD BZG08_26685 ENOG4105C3K feS assembly ATPase SufC BZG08_26690 ENOG4105D01 (LipO)protein BZG08_26695 ENOG4105D01 (LipO)protein BZG08_26700 ENOG4108UMI ABC transporter, permease BZG08_26745 ENOG41080E8 Transcriptional regulator, Spx MgsR family BZG08_26800 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BZG08_26830 ENOG4108W8B Beta-lactamase domain protein BZG08_26835 ENOG4105C1G acyl-Coa dehydrogenase BZG08_26845 ENOG4105CHU acetyl-coa acetyltransferase BZG08_26865 ENOG4105DZ1 carboxypeptidase BZG08_26885 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BZG08_26905 ENOG4108SUT Major Facilitator Superfamily BZG08_26910 ENOG4107R7I amino acid BZG08_26920 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BZG08_26930 ENOG4107AYK membrAne BZG08_26970 ENOG4107ZTW SNARE associated Golgi BZG08_26980 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BZG08_26985 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZG08_26990 ENOG4105BZU Histidine kinase BZG08_27000 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BZG08_27015 ENOG4105VG1 fes assembly suf system protein BZG08_27020 ENOG4105D4Y metalloprotease BZG08_27040 ENOG4107S91 Sodium hydrogen exchanger BZG08_27045 ENOG4105NCW Trka-c domain protein BZG08_27060 ENOG4108RMU ferritin dps family protein BZG08_27075 ENOG4108URH decarboxylase BZG08_27100 ENOG4105D9N nucleoside BZG08_27105 ENOG4105D9N nucleoside BZG08_27120 ENOG4108RYK Nad-dependent epimerase dehydratase BZG08_27150 ENOG4105CV8 reductase BZG08_27155 ENOG4105F27 Major Facilitator BZG08_27160 ENOG4105KVH Transcriptional regulator BZG08_27175 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BZG08_27180 ENOG4105D4A Cell wall formation (By similarity) BZG08_27190 ENOG4105C8Q Methyl-accepting chemotaxis BZG08_27200 ENOG4105WMR Protein CrcB homolog BZG08_27205 ENOG4105WMR Protein CrcB homolog BZG08_27220 ENOG4108MK9 spermidine N(1)-acetyltransferase BZG08_27225 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BZG08_27245 ENOG4108IPW abc transporter atp-binding protein BZG08_27250 ENOG4105CM4 permease protein BZG08_27285 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BZG08_27295 ENOG4105XZU Preprotein translocase, subunit SecG BZG08_27300 ENOG41067MG lrgb family BZG08_27410 ENOG4105EFC phage portal protein HK97 family BZG08_27435 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BZG08_27445 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BZG08_27450 ENOG4105CP7 Triose-phosphate isomerase BZG08_27475 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BZG08_27495 ENOG41090VF Stage v sporulation protein ac BZG08_27500 ENOG4105CZ3 stage V sporulation protein ad BZG08_27515 ENOG4105H67 Protein of unknown function (DUF421) BZG08_27520 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BZG08_27525 ENOG4105KRI phosphocarrier protein (HPr BZG08_27535 ENOG4105CHW UPF0052 protein BZG08_27545 ENOG4108Z4K mutator MutT protein BZG08_27555 ENOG4105C3M thioredoxin reductase BZG08_27565 ENOG4108S4C acetyltransferase BZG08_27585 ENOG41086DT Membrane protein of unknown function BZG08_27595 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BZG08_27600 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BZG08_27605 ENOG4105D7V transposase BZG08_27620 ENOG4107TXC Transcriptional regulator BZG08_27640 ENOG41067QW Transcriptional regulator BZG08_27650 ENOG4105DUM transcriptional regulator, lysR family BZG08_27660 ENOG4108WS4 fmn reductase BZG08_27675 ENOG4105BZ1 (ABC) transporter BZG08_27685 ENOG4105CN1 protease BZG08_27690 ENOG4105CRP Part of the ABC transporter FtsEX involved in BZG08_27695 ENOG4105CAK Cell division ATP-binding protein ftsE BZG08_27710 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BZG08_27720 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BZG08_27725 ENOG4105MS2 ribosomal subunit Interface protein BZG08_27730 ENOG4105VEQ Cold shock protein BZG08_27735 ENOG41081UC Inherit from COG: Competence protein BZG08_27750 ENOG4105KVH Transcriptional regulator BZG08_27765 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BZG08_27770 ENOG4108KGH TRANSCRIPTIONal BZG08_27775 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BZG08_27780 ENOG4105C6Y Udp-glucose 6-dehydrogenase BZG08_27785 ENOG4105ESV Glycosyl transferase, family 4 BZG08_27795 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BZG08_27810 ENOG410901P UPF0249 protein BZG08_27815 ENOG4105F8D glycoside hydrolase family 4 BZG08_27820 ENOG4105VCP PTS System BZG08_27825 ENOG4105CK1 PTS System BZG08_27835 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BZG08_27840 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BZG08_27845 ENOG4105VCP PTS System BZG08_27855 ENOG4105VZJ PTS System BZG08_27870 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BZG08_27875 ENOG4105ECB domain protein BZG08_27880 ENOG4107RSM transcriptional regulator BZG08_27925 ENOG4105DAA L-lactate BZG08_27935 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BZG08_27945 ENOG4105E0M Sulfatase BZG08_27985 ENOG4105C94 Transporter BZG08_27995 ENOG41069ER domain protein BZG08_28020 ENOG4105KBK Zinc finger, swim domain protein BZG08_28025 ENOG4105C0D helicase BZG08_28055 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BZG08_28065 ENOG4107RBB ABC transporter, permease BZG08_28070 ENOG4105C19 ABC transporter BZG08_28090 ENOG4105CXY transporter BZG08_28105 ENOG4105BZU Histidine kinase BZG08_28110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZG08_28115 ENOG4105CMR udp-glucose 4-epimerase BZG08_28130 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BZG08_28135 ENOG4105EY8 ABC transporter BZG08_28190 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BZG08_28205 ENOG4105FRN stage II sporulation protein BZG08_28240 ENOG4106778 Protein of unknown function (DUF1146) BZG08_28245 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BZG08_28250 ENOG4105C8S subunit m BZG08_28255 ENOG4105D65 subunit l BZG08_28280 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BZG08_28285 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BZG08_28295 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BZG08_28300 ENOG4105BZU Histidine kinase BZG08_28355 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BZG08_28360 ENOG41062M3 atp synthase BZG08_28390 ENOG4108YZG isomerase BZG08_28410 ENOG4108VGI doxx family BZG08_28415 ENOG4107XC4 flavin reductase domain protein, FMN-binding BZG08_28430 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BZG08_28440 ENOG4108ZXQ stage ii sporulation protein r BZG08_28445 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BZG08_28450 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BZG08_28465 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BZG08_28470 ENOG4105CBT Fructose-1,6-bisphosphatase BZG08_28480 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BZG08_28515 ENOG4105C1G acyl-Coa dehydrogenase BZG08_28520 ENOG4105C1G acyl-Coa dehydrogenase BZG08_28525 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BZG08_28535 ENOG4105DF6 Fe-S oxidoreductase BZG08_28550 ENOG4105BZU Histidine kinase BZG08_28580 ENOG4105BZU Histidine kinase BZG08_28585 ENOG4105KCT ABC transporter BZG08_28590 ENOG4108M15 ABC transporter BZG08_28595 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BZG08_28620 ENOG4105IIU Aminopeptidase BZG08_28640 ENOG4105EMN RNA polymerase sigma factor BZG08_28650 ENOG410684U Domain of unknown function (DUF1934) BZG08_28675 ENOG4105CYW agmatinase BZG08_28685 ENOG4105DXB Major Facilitator superfamily BZG08_28690 ENOG4107SWG transcriptional regulator MERR family BZG08_28695 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BZG08_28700 ENOG4105BZ4 penicillin-binding protein BZG08_28705 ENOG4108XFG YwhD family BZG08_28710 ENOG4108Z4T Peptidase M50 BZG08_28715 ENOG41069HH 4-oxalocrotonate tautomerase BZG08_28720 ENOG4105DCI Phosphohydrolase BZG08_28725 ENOG4108MES Periplasmic binding protein BZG08_28730 ENOG4105E0A ABC, transporter BZG08_28735 ENOG4105EHG Permease protein BZG08_28740 ENOG4105DQ5 transport system permease protein BZG08_28745 ENOG4105DQ5 transport system permease protein BZG08_28755 ENOG4108VCI transcription factor, rsfa family BZG08_28770 ENOG4108IJ2 phosphate acetyltransferase BZG08_28785 ENOG4108VKI Cell wall hydrolase BZG08_28815 ENOG410667J hydrolase BZG08_28820 ENOG4105VCH membrane BZG08_28830 ENOG4108TU7 Inherit from COG: (ABC) transporter BZG08_28835 ENOG4105CJ1 ABC, transporter BZG08_28840 ENOG41090WU lipolytic protein G-D-S-L family BZG08_28855 ENOG4105D6E homoserine dehydrogenase BZG08_28880 ENOG4108Y4K DNA-binding transcriptional activator BZG08_28890 ENOG4105WH1 Two component transcriptional regulator luxr family BZG08_28900 ENOG4105DWF phosphomethylpyrimidine kinase BZG08_28905 ENOG4105BZU Histidine kinase BZG08_28910 ENOG4105VCD cytoplasmic protein BZG08_28915 ENOG4105D22 carbon starvation protein BZG08_28920 ENOG4105DY9 regulatoR BZG08_28925 ENOG41079KZ Major Facilitator Superfamily BZG08_28945 ENOG4105EN6 Membrane BZG08_28950 ENOG4106YBV Methyl-accepting chemotaxis BZG08_28960 ENOG4108S4H thioesterase Superfamily protein BZG08_28970 ENOG4105JEU Glycosyl transferase, family 2 BZG08_28975 ENOG4105C5H ABC transporter BZG08_29005 ENOG4105CKK Glycosyl transferase, family 2 BZG08_29010 ENOG41067SE Tetr family transcriptional regulator BZG08_29020 ENOG4105E0X reductase BZG08_29025 ENOG4106F5Q Membrane BZG08_29040 ENOG4105DY9 regulatoR BZG08_29045 ENOG4108HRK Histidine kinase BZG08_29050 ENOG4107RGD Major Facilitator superfamily BZG08_29070 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BZG08_29080 ENOG4105IW1 AmiS UreI transporter BZG08_29090 ENOG4105CMR udp-glucose 4-epimerase BZG08_29095 ENOG4108UT2 hemolysin iii BZG08_29105 ENOG4105C1J atp-dependent rna helicase BZG08_29120 ENOG4105DPN Oligoendopeptidase f BZG08_29140 ENOG4105C0H protease BZG08_29145 ENOG4105Q2H domain protein BZG08_29160 ENOG4105BZU Histidine kinase BZG08_29165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZG08_29195 ENOG4105CDU Replicative dna helicase BZG08_29205 ENOG4105BZR domain protein BZG08_29210 ENOG4108XMW Membrane BZG08_29220 ENOG4108UUM single-stranded DNA-binding protein BZG08_29230 ENOG4105C3G gtp-binding protein BZG08_29235 ENOG4105VDK protein, conserved in bacteria BZG08_29240 ENOG4105D8X mechanosensitive ion channel BZG08_29245 ENOG4108ZDA Sporulation protein YyaC BZG08_29250 ENOG4105FA0 parb-like partition protein BZG08_29255 ENOG4107QJE Chromosome Partitioning Protein BZG08_29275 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BZG08_29285 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BZG08_29350 ENOG4105EKQ RNA-directed DNA polymerase BZG08_29450 ENOG4105EKQ RNA-directed DNA polymerase BZG08_29580 ENOG4105CNU cell division protein FtsK BZG08_29805 ENOG4105DHF Membrane BZG08_29830 ENOG4106AKK s-layer domain-containing protein BZG08_29835 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BZG08_29865 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BZG08_29870 ENOG4105C6Y Udp-glucose 6-dehydrogenase BZG08_29950 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BZG08_30070 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BZG08_30100 ENOG4108IBT Inherit from COG: transposase BZG08_30110 ENOG4105DQ6 Transposase BZG08_30135 ENOG4108MEK Metal-binding protein YodA BZG08_30150 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) BZG08_30180 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)