locus-tag class description AW166_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AW166_00015 ENOG410848D S4 domain protein YaaA AW166_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW166_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AW166_00100 ENOG4105ZMH deoxynucleoside kinase AW166_00110 ENOG4105GTG Isochorismatase AW166_00120 ENOG4108Z6B deaminase AW166_00130 ENOG4105C6E dna polymerase iii AW166_00150 ENOG41067KS pro-sigma K processing AW166_00185 ENOG4105CXN decarboxylase AW166_00195 ENOG4105FA2 dna polymerase iii AW166_00200 ENOG4105MA4 psp1 domain protein AW166_00210 ENOG41060K3 Methyltransferase AW166_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AW166_00225 ENOG4105KRN Transcriptional regulator, abrb family AW166_00235 ENOG4105F8V Hydrolase, tatD family AW166_00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AW166_00250 ENOG4105XFA sporulation peptidase YabG AW166_00255 ENOG4105W42 Veg protein AW166_00270 ENOG4105DFT pur operon repressor AW166_00275 ENOG4105KME endoribonuclease L-psp AW166_00290 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AW166_00295 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AW166_00305 ENOG4108JA2 transcriptioN-repair coupling factor AW166_00310 ENOG4108M14 stage v sporulation protein t AW166_00320 ENOG4108IY2 MazG family AW166_00325 ENOG41082I2 s4 domain protein AW166_00330 ENOG4105VYY sporulation protein yabp AW166_00345 ENOG41060GV RNA binding s1 domain protein AW166_00365 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AW166_00370 ENOG4108UGV hypoxanthine phosphoribosyltransferase AW166_00375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AW166_00390 ENOG4105C6T cysteine synthase AW166_00395 ENOG4105CRQ synthase (Component I) AW166_00400 ENOG4105DDQ anthranilate synthase AW166_00405 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AW166_00410 ENOG4105EEI dihydropteroate synthase AW166_00415 ENOG4105KRF dihydroneopterin aldolase AW166_00420 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AW166_00430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AW166_00460 ENOG4108Z0C Uvrb UvrC protein AW166_00475 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AW166_00485 ENOG4105CTP PilT protein domain protein AW166_00505 ENOG4105D7W serine acetyltransferase AW166_00520 ENOG4105C2N RNA methyltransferase TrmH family group 3 AW166_00525 ENOG4105M0M Tetracycline resistance protein AW166_00530 ENOG4105QIV RNA polymerase AW166_00545 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AW166_00570 ENOG4107Y49 methyltransferase AW166_00580 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AW166_00585 ENOG4105XPM ribosomal protein AW166_00690 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AW166_00715 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AW166_00725 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AW166_00735 ENOG41067V7 50S ribosomal protein L36 AW166_00765 ENOG4108JJB ABC transporter AW166_00770 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AW166_00775 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AW166_00800 ENOG4105D1F ATP-binding protein AW166_00815 ENOG4108NMV polysaccharide deacetylase AW166_00900 ENOG4105C8B TIGR00159 family AW166_00905 ENOG4107U5W ybbr family AW166_00920 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AW166_00925 ENOG4108VQT Alpha beta hydrolase fold protein AW166_00945 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AW166_00950 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AW166_00985 ENOG4108PSK reductase AW166_00990 ENOG4108UMI ABC transporter, permease AW166_00995 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AW166_01000 ENOG4105D01 (LipO)protein AW166_01005 ENOG4105EE1 crotonyl-CoA reductase AW166_01015 ENOG4105IQ5 FAD linked oxidase domain protein AW166_01030 ENOG4105C2C drug resistance transporter, Bcr CflA AW166_01045 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW166_01050 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW166_01055 ENOG4105C3U ABC transporter AW166_01060 ENOG4108JQ7 (ABC) transporter AW166_01090 ENOG4108J59 Extracellular solute-binding protein, family 5 AW166_01095 ENOG4108J59 Extracellular solute-binding protein, family 5 AW166_01105 ENOG4105II7 pyrroline-5-carboxylate reductase AW166_01115 ENOG4107XDY Nicotinamide Mononucleotide Transporter AW166_01125 ENOG4105E0C molybdate abc transporter AW166_01130 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AW166_01135 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AW166_01140 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AW166_01155 ENOG4105EGI Transcriptional regulator AW166_01170 ENOG4105F6E Acyl-transferase AW166_01190 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AW166_01205 ENOG4108RE7 deoxyribonuclease AW166_01210 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AW166_01235 ENOG4105C5H ABC transporter AW166_01250 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AW166_01260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW166_01265 ENOG4105C3U ABC transporter AW166_01270 ENOG4108JQ7 (ABC) transporter AW166_01295 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AW166_01300 ENOG4105ERH Fumarylacetoacetate hydrolase AW166_01310 ENOG4108SC4 )-transporter AW166_01315 ENOG4105CPF Cell wall formation (By similarity) AW166_01320 ENOG4105CPF Cell wall formation (By similarity) AW166_01325 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AW166_01340 ENOG4107ZXI Rhomboid family AW166_01350 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AW166_01355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AW166_01365 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AW166_01465 ENOG4105K8N protein family UPF0079, ATPase AW166_01470 ENOG41072GX Peptidase M22 Glycoprotease AW166_01475 ENOG410801F ribosomal-protein-alanine acetyltransferase AW166_01480 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AW166_01485 ENOG4105C5H ABC transporter AW166_01500 ENOG4108TYN CAAX amino terminal protease family protein AW166_01520 ENOG4105C7N Xanthine uracil vitamin C permease AW166_01530 ENOG4105BZU Histidine kinase AW166_01560 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AW166_01600 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AW166_01620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW166_01640 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AW166_01645 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AW166_01650 ENOG4105C83 adenylosuccinate lyase AW166_01660 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AW166_01685 ENOG4108V3E phosphoribosylglycinamide formyltransferase AW166_01695 ENOG4105C12 Phosphoribosylglycinamide synthetase AW166_01720 ENOG4105C4R Atp-dependent dna helicase AW166_01750 ENOG4108W2Y isochorismatase AW166_01755 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AW166_01760 ENOG4108UMI ABC transporter, permease AW166_01765 ENOG4105D01 (LipO)protein AW166_01785 ENOG410834F Transcriptional regulator AW166_01810 ENOG4105CBD Diacylglycerol kinase AW166_01815 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AW166_01820 ENOG4108JPW Aminotransferase AW166_01830 ENOG4105C26 Dehydrogenase AW166_01835 ENOG4105KPY Small multidrug resistance protein AW166_01855 ENOG4105D9N nucleoside AW166_01860 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AW166_01875 ENOG4108W15 Protein of unknown function (DUF1456) AW166_01890 ENOG4105DTQ mandelate racemase muconate lactonizing AW166_01900 ENOG4105DFD Na H antiporter AW166_01920 ENOG4105D3R alkyl hydroperoxide reductase AW166_01925 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AW166_01935 ENOG4107W7X Aldolase AW166_01940 ENOG4105EHG Permease protein AW166_01945 ENOG4105DQ5 transport system permease protein AW166_01950 ENOG4108V5C ABC transporter AW166_01975 ENOG4106UIA AW166_01980 ENOG4106UIA AW166_02005 ENOG4105BZU Histidine kinase AW166_02025 ENOG410756H nucleotidyltransferase AW166_02030 ENOG4105D2S major facilitator superfamily AW166_02045 ENOG4105E5Q amino acid AbC transporter AW166_02050 ENOG4105EAB amino acid AbC transporter AW166_02065 ENOG4105C8Q Methyl-accepting chemotaxis AW166_02070 ENOG4105C8Q Methyl-accepting chemotaxis AW166_02080 ENOG4105CI1 PTS System AW166_02110 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AW166_02125 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AW166_02140 ENOG4105C5H ABC transporter AW166_02165 ENOG41062JF Transcriptional regulator AW166_02185 ENOG4105DEU major facilitator superfamily AW166_02200 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) AW166_02215 ENOG4108N0M stress protein AW166_02220 ENOG4106FN3 tellurium resistance protein AW166_02225 ENOG4106FN3 tellurium resistance protein AW166_02230 ENOG4107TS3 membrane protein, TerC AW166_02235 ENOG4108TTB tellurium resistance protein AW166_02255 ENOG4105KJF protein tyrosine phosphatase AW166_02265 ENOG4107U9T Pfam:Ribonuclease_BN AW166_02270 ENOG4105C59 p-type ATPase AW166_02275 ENOG4108IPJ Membrane AW166_02295 ENOG4107ZTW SNARE associated Golgi AW166_02310 ENOG410606W general stress protein AW166_02315 ENOG4105UPD Calcium Proton AW166_02355 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AW166_02360 ENOG4105VTR Integrase AW166_02365 ENOG4108IMY Transcriptional regulator AW166_02640 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AW166_02650 ENOG4108JUB Transcriptional regulator AW166_02660 ENOG4108IQI permease AW166_02695 ENOG4105CSV Glutaminase AW166_02705 ENOG4108A04 Beta-lactamase AW166_02720 ENOG4105CKK Glycosyl transferase, family 2 AW166_02730 ENOG4107QQG Dehydrogenase AW166_02735 ENOG4105C3I Nad-dependent epimerase dehydratase AW166_02755 ENOG4105F1A Pyruvate formate-lyase AW166_02775 ENOG4105CI2 imidazolone-5-propionate hydrolase AW166_02780 ENOG4105ECP epimerase AW166_02810 ENOG41067AE Membrane-bound metal-dependent hydrolase AW166_02815 ENOG4105CEN a g-specific adenine glycosylase AW166_02820 ENOG4106BXE AW166_02840 ENOG4105BZ1 (ABC) transporter AW166_02845 ENOG4107NBY Membrane AW166_02850 ENOG4105CBC glutamate synthase AW166_02860 ENOG4108IUW ABC transporter AW166_02880 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AW166_02885 ENOG4105G5W regulator Fur family AW166_03000 ENOG4108JQC penicillin-binding protein 1A AW166_03005 ENOG4107ZQN disulfide bond AW166_03015 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AW166_03025 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AW166_03030 ENOG4105BZU Histidine kinase AW166_03040 ENOG4105CYN Serine protein kinase AW166_03065 ENOG4105C94 Transporter AW166_03080 ENOG4105DZ6 Band 7 protein AW166_03090 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AW166_03100 ENOG4105D4T Citrate transporter AW166_03120 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AW166_03125 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW166_03130 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AW166_03135 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AW166_03140 ENOG4105BZ7 extracellular solute-binding protein family 1 AW166_03145 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AW166_03150 ENOG4108STX response regulator AW166_03155 ENOG4105US7 Histidine kinase AW166_03180 ENOG4108MRH transcriptional regulatory protein AW166_03190 ENOG4105C6K Malic enzyme AW166_03200 ENOG4108UZ3 Transporter AW166_03205 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW166_03215 ENOG4105BZU Histidine kinase AW166_03220 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW166_03230 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AW166_03235 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AW166_03240 ENOG4108JB9 formate dehydrogenase AW166_03260 ENOG4105CUB amino acid AW166_03270 ENOG4105C59 p-type ATPase AW166_03275 ENOG4105DAP Nicotinate phosphoribosyltransferase AW166_03305 ENOG41073R8 VanW family AW166_03310 ENOG4108KGH TRANSCRIPTIONal AW166_03315 ENOG4105D9N nucleoside AW166_03320 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AW166_03325 ENOG4105C37 (CBS) domain AW166_03330 ENOG4108IJ0 Aspartate ammonia-lyase AW166_03335 ENOG4105DAA L-lactate AW166_03350 ENOG4105DUX Transporter AW166_03355 ENOG4108MES Periplasmic binding protein AW166_03360 ENOG4105DQ5 transport system permease protein AW166_03365 ENOG4108IHU transport system permease protein AW166_03370 ENOG4105E0A ABC, transporter AW166_03375 ENOG4105DMQ Methyltransferase AW166_03385 ENOG4105EXW epimerase dehydratase AW166_03395 ENOG4107T89 von Willebrand factor, type A AW166_03400 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AW166_03405 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW166_03420 ENOG4105BZU Histidine kinase AW166_03425 ENOG4105D5Q Arginine ornithine antiporter AW166_03430 ENOG4107414 GntR family transcriptional regulator AW166_03435 ENOG4105C5Y PTS System AW166_03440 ENOG4105CG3 alpha amylase, catalytic region AW166_03455 ENOG4105E1K spore germination protein AW166_03465 ENOG4105CRN Aminoglycoside phosphotransferase AW166_03470 ENOG4105BZG amino acid carrier protein AW166_03475 ENOG4105CDA abc transporter atp-binding protein AW166_03480 ENOG4105CT1 (ABC) transporter AW166_03485 ENOG4105EAD ABC transporter AW166_03490 ENOG4105DRP amino acid AbC transporter AW166_03495 ENOG4108IQI permease AW166_03520 ENOG4105D29 Helix-turn-helix type 11 domain protein AW166_03525 ENOG4105NAE bifunctional deaminase-reductase domain protein AW166_03530 ENOG4105BZU Histidine kinase AW166_03545 ENOG4105CHH sulfate transporter AW166_03550 ENOG41068KF Universal stress protein AW166_03560 ENOG4105DEF Extracellular solute-binding protein, family 5 AW166_03570 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW166_03575 ENOG4108JQ7 (ABC) transporter AW166_03585 ENOG4105CXY transporter AW166_03590 ENOG41067TZ transcriptional regulator, MarR family AW166_03595 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW166_03600 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW166_03605 ENOG4105ETE Transcriptional regulator (LacI family AW166_03610 ENOG4108RVA ribokinase AW166_03620 ENOG4105C2J ABC transporter AW166_03625 ENOG4105CNN ABC, transporter AW166_03630 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AW166_03635 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AW166_03695 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AW166_03700 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AW166_03705 ENOG41069ER domain protein AW166_03710 ENOG4105VZ8 Transcriptional regulator AW166_03715 ENOG4107D63 AW166_03725 ENOG4105DUX Transporter AW166_03745 ENOG4105C85 amino acid AW166_03750 ENOG4105C7N Xanthine uracil vitamin C permease AW166_03790 ENOG4105BZ9 Cytochrome C oxidase, subunit I AW166_03795 ENOG4105E2S oxidase) subunit II AW166_03800 ENOG4108IQI permease AW166_03815 ENOG4106CAD Protein of unknown function (DUF3311) AW166_03820 ENOG4105E1V na solute symporter AW166_03835 ENOG4108NHD germination protein AW166_03845 ENOG4105CE1 Ferrous iron transport protein b AW166_03850 ENOG4105CE1 Ferrous iron transport protein b AW166_03855 ENOG4105CE1 Ferrous iron transport protein b AW166_03860 ENOG4105CVA phosphate AW166_03865 ENOG4105C8U phosphate abc transporter AW166_03870 ENOG4105E2Z phosphate ABC transporter (Permease AW166_03995 ENOG41080XQ Signal transduction protein with cbs domains AW166_04020 ENOG4105ETU transcriptional activator (TenA AW166_04030 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AW166_04040 ENOG4108VEU Thiamine monophosphate synthase AW166_04045 ENOG41080HI glycine oxidase AW166_04060 ENOG4105D06 uba thif-type nad fad binding protein AW166_04065 ENOG4105DWF phosphomethylpyrimidine kinase AW166_04120 ENOG4108INS Transcriptional regulator AW166_04135 ENOG4105C7N Xanthine uracil vitamin C permease AW166_04165 ENOG4105C5Y PTS System AW166_04225 ENOG4107Y03 Nitroreductase AW166_04230 ENOG4105ED1 spovr family AW166_04255 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AW166_04260 ENOG4105XTG Pfam:DUF156 AW166_04265 ENOG4105VFE sira family AW166_04270 ENOG4107TPS domain protein AW166_04275 ENOG4105VFE sira family AW166_04280 ENOG41085GJ domain protein AW166_04290 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AW166_04295 ENOG41087NI Sulfite exporter TauE/SafE AW166_04305 ENOG4108KGH TRANSCRIPTIONal AW166_04330 ENOG4105EMD TRANSCRIPTIONal AW166_04335 ENOG4105VCP PTS System AW166_04340 ENOG4105VZJ PTS System AW166_04360 ENOG41069ER domain protein AW166_04365 ENOG4107RBB ABC transporter, permease AW166_04370 ENOG4105C19 ABC transporter AW166_04400 ENOG4105WEF catalase AW166_04435 ENOG4107T5V SNARE associated Golgi AW166_04470 ENOG4105CUB amino acid AW166_04475 ENOG4107RWR Sodium hydrogen exchanger AW166_04485 ENOG4106KNT transcriptional regulator AW166_04520 ENOG4108PCN EamA-like transporter family AW166_04525 ENOG4108YXU transcriptional regulator AsnC family AW166_04535 ENOG4105KPY Small multidrug resistance protein AW166_04540 ENOG4105KPY Small multidrug resistance protein AW166_04565 ENOG4105NF4 modulator of drug activity AW166_04570 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AW166_04575 ENOG4105E5W Transporter AW166_04585 ENOG4107RKG DJ-1/PfpI family AW166_04590 ENOG4105CH6 catalase AW166_04600 ENOG4105D5Q Arginine ornithine antiporter AW166_04605 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AW166_04615 ENOG4105C26 Dehydrogenase AW166_04625 ENOG4105BZ1 (ABC) transporter AW166_04640 ENOG4105DRP amino acid AbC transporter AW166_04645 ENOG4105CDA abc transporter atp-binding protein AW166_04660 ENOG410839P AW166_04695 ENOG4107FQX Alpha-acetolactate decarboxylase AW166_04725 ENOG4105D4P Coproporphyrinogen iii oxidase AW166_04740 ENOG4105CHH sulfate transporter AW166_04780 ENOG4106AKK s-layer domain-containing protein AW166_04790 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AW166_04795 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AW166_04810 ENOG4105CGU Enoyl-CoA hydratase AW166_04830 ENOG4105DER m42 family AW166_04850 ENOG4105CTU Proline racemase AW166_04895 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW166_04905 ENOG4108JQ7 (ABC) transporter AW166_04935 ENOG4105CSH Transporter AW166_04945 ENOG4108MRH transcriptional regulatory protein AW166_04995 ENOG4105CDU Replicative dna helicase AW166_05035 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW166_05085 ENOG4107P5I polyketide synthase AW166_05090 ENOG4108IG5 Transcriptional regulator AW166_05110 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AW166_05130 ENOG4105CMT Dihydroxyacetone kinase AW166_05145 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AW166_05150 ENOG410847I Transcriptional regulator, BadM Rrf2 family AW166_05175 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AW166_05240 ENOG4105WN5 stage II sporulation protein AW166_05250 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW166_05260 ENOG4108MJI response regulator AW166_05265 ENOG4105BZU Histidine kinase AW166_05270 ENOG4105BZU Histidine kinase AW166_05295 ENOG4105K8R UPF0145 protein AW166_05330 ENOG4107VRP DNA repair exonuclease AW166_05335 ENOG4106D4I domain protein AW166_05340 ENOG4105D7V transposase AW166_05355 ENOG4108IND Tetr family transcriptional regulator AW166_05360 ENOG4105EQ0 Major Facilitator superfamily AW166_05380 ENOG4108MUZ hydrolase AW166_05400 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AW166_05415 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AW166_05430 ENOG4105EMN RNA polymerase sigma factor AW166_05455 ENOG4105C57 major facilitator superfamily AW166_05460 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW166_05470 ENOG4105EEM helicase AW166_05475 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AW166_05505 ENOG4105K59 histidine triad (HIT) protein AW166_05535 ENOG410905X membrane-flanked domain protein AW166_05545 ENOG4105CKV Membrane AW166_05585 ENOG410905X membrane-flanked domain protein AW166_05590 ENOG4105CKV Membrane AW166_05595 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AW166_05600 ENOG4105BZ4 penicillin-binding protein AW166_05605 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AW166_05615 ENOG4105C1Q protoporphyrinogen oxidase AW166_05640 ENOG4105NA0 Transcriptional regulator AW166_05655 ENOG4105ECB domain protein AW166_05685 ENOG4106AXD AW166_05690 ENOG4108RQ5 Beta-lactamase domain-containing protein AW166_05695 ENOG4105DF9 Lipoate-protein, ligase AW166_05705 ENOG4105CEY Amp-dependent synthetase and ligase AW166_05735 ENOG4105CNA YD repeat protein AW166_05770 ENOG4105ENX hydrolase AW166_05780 ENOG4107RN3 metallophosphoesterase AW166_05785 ENOG4107TVP HD domain protein AW166_05795 ENOG4108AEY RNA polymerase sigma factor AW166_05800 ENOG41086D8 Transcriptional regulator AW166_05820 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW166_05845 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AW166_05850 ENOG4105C8Q Methyl-accepting chemotaxis AW166_05870 ENOG4105ZU5 s-layer protein AW166_05875 ENOG4107QP3 malate synthase g AW166_05890 ENOG4105VEQ Cold shock protein AW166_05905 ENOG4105XVF Competence transcription factor AW166_05920 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AW166_05925 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AW166_05970 ENOG4105ERH Fumarylacetoacetate hydrolase AW166_05995 ENOG4105CAQ asparagine synthetase AW166_06000 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AW166_06005 ENOG4105CH6 catalase AW166_06010 ENOG4105BZU Histidine kinase AW166_06035 ENOG4105QNR S1 RNA binding domain protein AW166_06045 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AW166_06055 ENOG4107AYK membrAne AW166_06060 ENOG41073B9 AW166_06070 ENOG4108KP7 hydrolase AW166_06085 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AW166_06110 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AW166_06115 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AW166_06130 ENOG4105C31 Tryptophanyl-tRNA synthetase AW166_06145 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW166_06150 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW166_06160 ENOG4108JQ7 (ABC) transporter AW166_06165 ENOG4105UQX Mate efflux family protein AW166_06190 ENOG4108ZCF integral membrane protein AW166_06200 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW166_06210 ENOG4105DPN Oligoendopeptidase f AW166_06225 ENOG4108Z18 K06886 hemoglobin AW166_06230 ENOG4105MIX Adenylate cyclase AW166_06245 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AW166_06250 ENOG4105EMS pseudouridine synthase AW166_06270 ENOG4105K64 Glycosyl transferase, family 2 AW166_06290 ENOG4107TVC Glycosyl transferase, family 2 AW166_06310 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AW166_06315 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AW166_06325 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AW166_06375 ENOG4108WVJ 2'-5' rna ligase AW166_06400 ENOG4105CK7 Sodium proline symporter AW166_06410 ENOG4105CRQ synthase (Component I) AW166_06415 ENOG4105DDQ anthranilate synthase AW166_06505 ENOG4105C7S Dehydrogenase AW166_06515 ENOG4105VZ8 Transcriptional regulator AW166_06575 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AW166_06585 ENOG4105DZ1 carboxypeptidase AW166_06590 ENOG4105VFR signal peptidase AW166_06625 ENOG4105C26 Dehydrogenase AW166_06630 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW166_06635 ENOG4105F38 ABC transporter, permease AW166_06640 ENOG4105D38 putrescine abc transporter AW166_06645 ENOG4107RUE extracellular solute-binding protein family 1 AW166_06655 ENOG4105EYF MMPL domain protein AW166_06665 ENOG4108YBP pseudouridine synthase AW166_06675 ENOG4105K4I Scp-like extracellular AW166_06680 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AW166_06685 ENOG4105CQB FAD linked oxidase domain protein AW166_06700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW166_06705 ENOG4105BZU Histidine kinase AW166_06710 ENOG4105JXH GntR family transcriptional regulator AW166_06730 ENOG4106A3R peptidase AW166_06740 ENOG4108QTI )-transporter AW166_06745 ENOG4107TS3 membrane protein, TerC AW166_06750 ENOG4105CZN Potassium uptake protein AW166_06755 ENOG410681C small acid-soluble spore protein AW166_06760 ENOG4108Z7G MaoC domain protein dehydratase AW166_06780 ENOG4105CHR reductase AW166_06810 ENOG4105C4Y ABC transporter AW166_06820 ENOG4107RCV ABC transporter, permease AW166_06825 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AW166_06840 ENOG4105E98 transcriptional regulator DeoR family AW166_06865 ENOG4105PXI polysaccharide deacetylase AW166_06875 ENOG4105BZU Histidine kinase AW166_06880 ENOG41090MY MarR family Transcriptional regulator AW166_06890 ENOG4106DF1 AW166_06900 ENOG4105BZU Histidine kinase AW166_06910 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AW166_06915 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AW166_06960 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AW166_06980 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AW166_06985 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AW166_06990 ENOG4105CZV ABC transporter AW166_07000 ENOG4105CJ1 ABC, transporter AW166_07040 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AW166_07045 ENOG4105EA8 2-Nitropropane dioxygenase AW166_07050 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AW166_07060 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AW166_07085 ENOG4105NQC Flavodoxin AW166_07120 ENOG4107QMU Mate efflux family protein AW166_07125 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AW166_07155 ENOG4105CZN Potassium uptake protein AW166_07160 ENOG41063Y9 AW166_07165 ENOG4105KBJ sporulation protein ytfj AW166_07195 ENOG4105CM2 brancheD-chain amino acid aminotransferase AW166_07200 ENOG4105C7K acetolactate synthase AW166_07205 ENOG4108ZP8 Acetolactate synthase small subunit AW166_07210 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AW166_07220 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AW166_07245 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AW166_07280 ENOG4107RVV histidinol phosphate phosphatase, hisj family AW166_07295 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AW166_07300 ENOG4105E0M Sulfatase AW166_07310 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AW166_07330 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AW166_07335 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AW166_07345 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AW166_07350 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AW166_07355 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AW166_07365 ENOG4105C8J )-transporter AW166_07385 ENOG4105DFD Na H antiporter AW166_07405 ENOG4105ENE Histidine kinase AW166_07410 ENOG4105WH1 Two component transcriptional regulator luxr family AW166_07430 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AW166_07455 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AW166_07480 ENOG4105CJ3 phosphate transporter AW166_07485 ENOG4107GRR phosphate transport regulator AW166_07490 ENOG4105BZ4 penicillin-binding protein AW166_07505 ENOG4105BZU Histidine kinase AW166_07510 ENOG4105I3N Conserved Protein AW166_07525 ENOG4105BZU Histidine kinase AW166_07560 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW166_07565 ENOG4105DZ1 carboxypeptidase AW166_07570 ENOG4108JIC nucleoside recognition domain protein AW166_07580 ENOG4105FE9 pseudouridine synthase AW166_07590 ENOG4107TWT Cytochrome c biogenesis protein AW166_07595 ENOG4105CRE cytochrome C AW166_07600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW166_07605 ENOG4105BZU Histidine kinase AW166_07610 ENOG4108WBT adenosyltransferase AW166_07625 ENOG4108SAX Membrane AW166_07635 ENOG4105T7X AW166_07640 ENOG4105C9U ATP-dependent DNA helicase RecQ AW166_07645 ENOG4105I7S Abortive infection protein AW166_07660 ENOG4107X2D transcriptional regulator, merr family AW166_07665 ENOG4108S6Z Negative regulator of genetic competence AW166_07690 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AW166_07695 ENOG4107RB3 L-asparaginase AW166_07730 ENOG4105S2F AW166_07735 ENOG41065D1 AW166_07765 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AW166_07780 ENOG4105XXQ heptaprenyl diphosphate synthase component I AW166_07790 ENOG4105EAH synthase AW166_07810 ENOG4105CIH Imidazole acetol-phosphate transaminase AW166_07815 ENOG41068YB TPR repeat-containing protein AW166_07830 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AW166_07835 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AW166_07840 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AW166_07870 ENOG4108JYZ YitT family AW166_07880 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AW166_07895 ENOG4105FJR Lmbe family AW166_07900 ENOG4105CPK Glycosyl transferase (Group 1 AW166_07940 ENOG4105DVT helicase AW166_07945 ENOG4105YAC AW166_07965 ENOG4105CSM endonuclease III AW166_07975 ENOG4105BZ4 penicillin-binding protein AW166_08030 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AW166_08040 ENOG4105DVT helicase AW166_08045 ENOG4105CTD carboxy-peptidase AW166_08060 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AW166_08070 ENOG4105C2W permease AW166_08075 ENOG4105DHF Membrane AW166_08080 ENOG410890F Dynamin family AW166_08090 ENOG4108W0I acetyltransferase AW166_08100 ENOG4105KHC sulfurtransferase AW166_08125 ENOG4106032 Glutathionylspermidine synthase AW166_08200 ENOG4108SZE gCN5-related N-acetyltransferase AW166_08220 ENOG41081VK Ribonuclease AW166_08285 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW166_08295 ENOG4107RWR Sodium hydrogen exchanger AW166_08305 ENOG4108Z5V transcriptional regulator, merr family AW166_08315 ENOG4105H67 Protein of unknown function (DUF421) AW166_08320 ENOG41080C8 DUF218 domain AW166_08375 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AW166_08385 ENOG4107R0U MotA TolQ exbB proton channel AW166_08390 ENOG4105ER2 Ompa motb domain protein AW166_08395 ENOG4107YTP response regulator receiver protein AW166_08405 ENOG4105DD5 Flagellar motor switch protein AW166_08420 ENOG4105BZU Histidine kinase AW166_08440 ENOG4105E1Q flagellar hook-associated protein AW166_08445 ENOG4105DTJ flagellar hook-associated protein AW166_08470 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AW166_08475 ENOG4108ZC9 flagellar basal-body rod protein flgc AW166_08480 ENOG41075Z6 flagellar hook-basal body complex protein fliE AW166_08485 ENOG4107U2N Flagellar M-ring protein AW166_08495 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AW166_08530 ENOG4105BZE flagellar hook protein, FlgE AW166_08555 ENOG4105K64 Glycosyl transferase, family 2 AW166_08585 ENOG4107TVC Glycosyl transferase, family 2 AW166_08610 ENOG4105I03 Flagellin AW166_08615 ENOG4105E4C Lytic transglycosylase catalytic AW166_08630 ENOG4105DD5 Flagellar motor switch protein AW166_08640 ENOG4105CN7 Flagellar biosynthetic protein FliP AW166_08645 ENOG4105VS8 Flagellar biosynthetic protein fliq AW166_08655 ENOG4105D00 flagellar biosynthetic protein flhB AW166_08660 ENOG4105D7B Flagellar biosynthesis protein flha AW166_08670 ENOG4105KTQ flagellar basal-body rod protein AW166_08675 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AW166_08700 ENOG4108RZE Tetr family transcriptional regulator AW166_08720 ENOG4105KAC Antibiotic biosynthesis monooxygenase AW166_08745 ENOG4105DUM transcriptional regulator, lysR family AW166_08750 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW166_08755 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AW166_08760 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AW166_08765 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AW166_08800 ENOG4105CVJ phosphoglycerate mutase AW166_08830 ENOG4105CAQ asparagine synthetase AW166_08850 ENOG4105PGM cation diffusion facilitator family transporter AW166_08860 ENOG4105DRR Transcriptional regulator, GntR family AW166_08865 ENOG4108UZ3 Transporter AW166_08870 ENOG4105CKI cobalamin synthesis protein AW166_08875 ENOG4108PJD permease AW166_08890 ENOG4105DFD Na H antiporter AW166_08895 ENOG4105C9Q fumarate hydratase class II AW166_08925 ENOG4105EC3 peptidase S51, dipeptidase E AW166_08945 ENOG4107QIV Cytochrome c biogenesis protein AW166_08980 ENOG4106BRA Membrane AW166_09015 ENOG4105CJ1 ABC, transporter AW166_09035 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AW166_09045 ENOG4108IJ0 Aspartate ammonia-lyase AW166_09050 ENOG4105C6K Malic enzyme AW166_09120 ENOG4105FVX AW166_09160 ENOG4105CSR polyphosphate kinase 2 AW166_09180 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AW166_09195 ENOG4105EU0 Major facilitator Superfamily AW166_09200 ENOG4105C6T cysteine synthase AW166_09220 ENOG4105C8J )-transporter AW166_09230 ENOG4105X5K response regulator receiver protein AW166_09235 ENOG4105H67 Protein of unknown function (DUF421) AW166_09250 ENOG4106KE4 Dehydrogenase AW166_09265 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AW166_09270 ENOG4105CHR reductase AW166_09275 ENOG4105CM2 brancheD-chain amino acid aminotransferase AW166_09280 ENOG4105C7K acetolactate synthase AW166_09285 ENOG4108ZP8 Acetolactate synthase small subunit AW166_09290 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AW166_09300 ENOG4105C7B Threonine dehydratase AW166_09325 ENOG4105C6X Major Facilitator AW166_09330 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AW166_09340 ENOG4105DY9 regulatoR AW166_09345 ENOG4105CYC Transferase AW166_09365 ENOG4105F6J Alpha beta hydrolase fold AW166_09370 ENOG4108J59 Extracellular solute-binding protein, family 5 AW166_09400 ENOG41068WN AW166_09420 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AW166_09425 ENOG4105C72 UPF0176 protein AW166_09435 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AW166_09470 ENOG4107RHR regulatoR AW166_09480 ENOG4105D9N nucleoside AW166_09485 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AW166_09520 ENOG4107RAQ aminopeptidase AW166_09525 ENOG4107STQ Multicopper oxidase AW166_09570 ENOG4108T5E Copper resistance protein AW166_09575 ENOG4105KTB nuclear export factor GLE1 AW166_09585 ENOG4107RT3 EamA-like transporter family AW166_09590 ENOG4105GZI Transcriptional regulator AW166_09595 ENOG4108Z40 Transcriptional regulator AW166_09600 ENOG4107ZXU DSBA oxidoreductase AW166_09605 ENOG4108TVJ Nitroreductase AW166_09615 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AW166_09620 ENOG4106F5Q Membrane AW166_09625 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AW166_09635 ENOG4105CKI cobalamin synthesis protein AW166_09655 ENOG4108Z7G MaoC domain protein dehydratase AW166_09660 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AW166_09670 ENOG4105C0Z ABC transporter AW166_09675 ENOG4108IV0 ABC, transporter AW166_09680 ENOG4105C32 Amino acid ABC transporter (Permease) AW166_09690 ENOG4105SKE transcriptional Regulator LysR family AW166_09700 ENOG4105MDS 4-oxalocrotonate tautomerase AW166_09710 ENOG4105YGB Transcriptional regulator AW166_09720 ENOG4105C4M (Ubiquinol oxidase) subunit I AW166_09725 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AW166_09730 ENOG4108JJ9 ABC, transporter AW166_09735 ENOG4108JJ8 (ABC) transporter AW166_09780 ENOG4105BZ1 (ABC) transporter AW166_09785 ENOG4105BZ1 (ABC) transporter AW166_09790 ENOG4105EFI regulatoR AW166_09795 ENOG4105BZU Histidine kinase AW166_09815 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AW166_09820 ENOG4108ZJ4 polysaccharide deacetylase AW166_09840 ENOG4105D6E homoserine dehydrogenase AW166_09865 ENOG4108KGH TRANSCRIPTIONal AW166_09875 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW166_09880 ENOG4105BZU Histidine kinase AW166_09885 ENOG4107VMI polysaccharide deacetylase AW166_09895 ENOG4105KT7 mgtC SapB transporter AW166_09900 ENOG4105VRR gCN5-related N-acetyltransferase AW166_09910 ENOG4105DUU IucA IucC family protein AW166_09915 ENOG4105CEY Amp-dependent synthetase and ligase AW166_09930 ENOG4108WBH protein TIM barrel AW166_09935 ENOG4105YWU small acid-soluble spore protein AW166_09945 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AW166_09995 ENOG4105KRN Transcriptional regulator, abrb family AW166_10005 ENOG4105YVS arsR family transcriptional regulator AW166_10010 ENOG4107SET aldo keto reductase AW166_10015 ENOG4107XZQ multidrug resistance protein AW166_10040 ENOG4105C8Q Methyl-accepting chemotaxis AW166_10060 ENOG4108K88 Membrane AW166_10065 ENOG4108WPJ Ferritin-like domain AW166_10080 ENOG4105DEN Luciferase family AW166_10100 ENOG4107QM2 Aldo Keto reductase AW166_10105 ENOG4105CKI cobalamin synthesis protein AW166_10170 ENOG4105DSE periplasmic solute binding protein AW166_10180 ENOG4105K4T epimerase AW166_10190 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AW166_10215 ENOG4105CVJ phosphoglycerate mutase AW166_10235 ENOG4107T5V SNARE associated Golgi AW166_10250 ENOG4108PJD permease AW166_10260 ENOG4108S4H thioesterase Superfamily protein AW166_10265 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW166_10285 ENOG4105SXS Protein of unknown function (DUF456) AW166_10290 ENOG4105C37 (CBS) domain AW166_10310 ENOG4108Z7R Chaperone CsaA AW166_10330 ENOG4108ZRV stage ii sporulation protein p AW166_10340 ENOG4108VXD carboxy-peptidase AW166_10350 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AW166_10375 ENOG4108X4Q Hydrolase AW166_10385 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AW166_10390 ENOG4107RBS Methyltransferase AW166_10405 ENOG41087PP glycosyltransferase MGT family AW166_10410 ENOG4108JYZ YitT family AW166_10415 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW166_10440 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AW166_10490 ENOG4105KBJ sporulation protein ytfj AW166_10515 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AW166_10535 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AW166_10540 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase AW166_10550 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AW166_10555 ENOG4105EMN RNA polymerase sigma factor AW166_10580 ENOG4108V06 Glutathione peroxidase AW166_10595 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AW166_10615 ENOG4108IUE nitrate reductase beta subunit AW166_10620 ENOG4105R3A Nitrate reductase AW166_10645 ENOG4107V6Q Cyclic nucleotide-binding domain AW166_10650 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AW166_10655 ENOG4105D06 uba thif-type nad fad binding protein AW166_10660 ENOG4105CVM Molybdenum cofactor synthesis domain protein AW166_10665 ENOG4108ZAF Molybdopterin AW166_10690 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AW166_10695 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AW166_10700 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AW166_10705 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AW166_10710 ENOG4108IFG nitrite reductase, (NAD(P)H) AW166_10715 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AW166_10750 ENOG4105MCT stage V sporulation protein S AW166_10765 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW166_10785 ENOG4105C5H ABC transporter AW166_10800 ENOG4108UUM single-stranded DNA-binding protein AW166_10815 ENOG41061H0 Monooxygenase AW166_10835 ENOG4107YX5 Pfam:DUF548 AW166_10840 ENOG4105C75 arginyL-tRNA synthetase AW166_10865 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AW166_10880 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AW166_10885 ENOG4105C5S asparaginyl-tRNA synthetase AW166_10905 ENOG4105EC2 ftsk spoIIIe AW166_11005 ENOG4105BZW Glycerate kinase AW166_11010 ENOG4107QPK )-transporter AW166_11015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW166_11020 ENOG41062D9 Histidine kinase AW166_11035 ENOG4105C8J )-transporter AW166_11055 ENOG4107XGZ Hydrolase AW166_11060 ENOG4105CY2 Citrate transporter AW166_11065 ENOG4105C0A alcohol dehydrogenase AW166_11080 ENOG4105KD7 acetyltransferase AW166_11110 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AW166_11130 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AW166_11145 ENOG4107RVG penicillin-binding protein AW166_11150 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AW166_11155 ENOG4105E9Q Acyl-transferase AW166_11160 ENOG4108UT2 hemolysin iii AW166_11170 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AW166_11180 ENOG4108RCR degv family AW166_11185 ENOG4105E8R UPF0173 metal-dependent hydrolase AW166_11190 ENOG4108KF3 Electron transport protein SCO1 SenC AW166_11195 ENOG4107Y70 Heat shock protein AW166_11200 ENOG4105CAQ asparagine synthetase AW166_11220 ENOG4108MES Periplasmic binding protein AW166_11225 ENOG4105F0I Aminotransferase AW166_11260 ENOG4105D8X mechanosensitive ion channel AW166_11265 ENOG4105BZU Histidine kinase AW166_11270 ENOG4105WH1 Two component transcriptional regulator luxr family AW166_11280 ENOG4106KNT transcriptional regulator AW166_11315 ENOG4105CMG Carbohydrate kinase AW166_11320 ENOG4105CMG Carbohydrate kinase AW166_11350 ENOG4108IJ8 ABC transporter AW166_11355 ENOG4105E90 ABC transporter AW166_11390 ENOG4105C37 (CBS) domain AW166_11415 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW166_11430 ENOG4107S4Y M20 DapE family protein YgeY AW166_11435 ENOG4108TSC N-acetyltransferase AW166_11440 ENOG4108JUB Transcriptional regulator AW166_11445 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AW166_11485 ENOG4108N23 SpoOM-related protein AW166_11490 ENOG410841Q phosphoesterase PA-phosphatase related protein AW166_11500 ENOG4105SZ6 Thioredoxin AW166_11515 ENOG4108IBT Inherit from COG: transposase AW166_11615 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AW166_11655 ENOG4105BZ4 penicillin-binding protein AW166_11665 ENOG4105CZM Major Facilitator AW166_11670 ENOG4105W8X HesB YadR YfhF-family protein AW166_11680 ENOG4105DXD 2-methylcitrate dehydratase AW166_11685 ENOG4105CR4 methylisocitrate lyase AW166_11690 ENOG4105C1G acyl-Coa dehydrogenase AW166_11695 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AW166_11705 ENOG4105N14 lysine exporter protein LysE YggA AW166_11710 ENOG4105E39 Enoyl-CoA hydratase AW166_11725 ENOG4107RFY SbcCD D subunit AW166_11730 ENOG4105EYH Exonuclease AW166_11760 ENOG4105FCD Major Facilitator AW166_11765 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AW166_11770 ENOG4105E4F Isochorismate synthase AW166_11775 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AW166_11780 ENOG4105WQI isochorismatase AW166_11785 ENOG4105CEY Amp-dependent synthetase and ligase AW166_11790 ENOG4105WQT MbtH domain protein AW166_11795 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW166_11810 ENOG4105K70 DNA-binding protein AW166_11830 ENOG4105BZG amino acid carrier protein AW166_11850 ENOG4105FE9 pseudouridine synthase AW166_11855 ENOG4105C22 threonyL-tRNA synthetase AW166_11870 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AW166_11895 ENOG4108D32 Methyltransferase AW166_11925 ENOG41081I9 integral membrane protein AW166_11940 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AW166_11950 ENOG4105EYF MMPL domain protein AW166_11975 ENOG4105WCN acetyltransferase AW166_12005 ENOG4105C1Q protoporphyrinogen oxidase AW166_12015 ENOG41068WN AW166_12025 ENOG4105VEQ Cold shock protein AW166_12045 ENOG410667J hydrolase AW166_12090 ENOG4107V2S Transcriptional regulator AW166_12095 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AW166_12110 ENOG4105DND Transcriptional regulator AW166_12115 ENOG4108RPX mosc domain containing protein AW166_12130 ENOG4105BZ1 (ABC) transporter AW166_12135 ENOG4105BZ1 (ABC) transporter AW166_12155 ENOG4108JCI Transcriptional regulator AW166_12185 ENOG4108KPJ rna polymerase sigma factor AW166_12235 ENOG4105RD7 BadF BadG BcrA BcrD AW166_12245 ENOG4107STF Involved in phosphonate degradation (By similarity) AW166_12265 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AW166_12280 ENOG4105C1J atp-dependent rna helicase AW166_12295 ENOG4108RZE Tetr family transcriptional regulator AW166_12315 ENOG41088CC tellurite resistance protein tehB AW166_12325 ENOG4108I0C methyltransferase AW166_12330 ENOG4107RA9 decarboxylase AW166_12335 ENOG41090HR transcriptional regulator AW166_12375 ENOG4105CIN aminoacyl-histidine dipeptidase AW166_12400 ENOG4107RF6 penicillin-binding protein AW166_12415 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AW166_12420 ENOG4105ETE Transcriptional regulator (LacI family AW166_12425 ENOG4105IE8 Alpha-ketoglutarate permease AW166_12430 ENOG4105CK5 oxidoreductase AW166_12455 ENOG4105D2N Aldolase AW166_12460 ENOG4105DH8 myo-inositol catabolism AW166_12490 ENOG4105VZ8 Transcriptional regulator AW166_12505 ENOG4108VXD carboxy-peptidase AW166_12525 ENOG41067SE Tetr family transcriptional regulator AW166_12530 ENOG4105C5H ABC transporter AW166_12540 ENOG4105BZU Histidine kinase AW166_12550 ENOG4106ANW SMI1_KNR4 AW166_12555 ENOG4105CEP NADH dehydrogenase AW166_12560 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AW166_12575 ENOG4105CJ1 ABC, transporter AW166_12585 ENOG4107Z3H Transcriptional regulator, TetR family AW166_12600 ENOG4105C1G acyl-Coa dehydrogenase AW166_12605 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AW166_12610 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AW166_12615 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AW166_12620 ENOG4105E39 Enoyl-CoA hydratase AW166_12625 ENOG4107QX3 carboxylase AW166_12630 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AW166_12640 ENOG4105WCN acetyltransferase AW166_12645 ENOG4105DBI uridine monophosphokinase AW166_12660 ENOG4105DZ1 carboxypeptidase AW166_12675 ENOG4105T9C HD domain AW166_12685 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AW166_12725 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AW166_12725 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AW166_12740 ENOG4105FQP Beta-lactamase AW166_12750 ENOG4107Y80 Major Facilitator superfamily AW166_12770 ENOG4105CUV Homoserine Kinase AW166_12805 ENOG4105CPQ Dehydrogenase AW166_12820 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AW166_12825 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AW166_12920 ENOG4105ETU transcriptional activator (TenA AW166_13030 ENOG410667J hydrolase AW166_13040 ENOG4105BZU Histidine kinase AW166_13045 ENOG4107RF6 penicillin-binding protein AW166_13065 ENOG4108JJB ABC transporter AW166_13075 ENOG4108HGU Histidine kinase AW166_13090 ENOG4105CB2 alcohol dehydrogenase AW166_13095 ENOG4105CJN penicillin-binding protein AW166_13105 ENOG4105FQP Beta-lactamase AW166_13140 ENOG4108V4B ThiJ pfpI AW166_13170 ENOG4107Y80 Major Facilitator superfamily AW166_13185 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AW166_13205 ENOG4107Y9U Membrane AW166_13240 ENOG4105FCD Major Facilitator AW166_13255 ENOG4105E09 nadh pyrophosphatase AW166_13260 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AW166_13265 ENOG4108Z4K mutator MutT protein AW166_13300 ENOG4108XI2 Domain of unknown function (DUF1963) AW166_13330 ENOG4108NRW Phospholipase, patatin family AW166_13335 ENOG4105KWG Pfam:DUF1696 AW166_13370 ENOG4105PKS Excinuclease abc c subunit domain protein AW166_13410 ENOG4107VFR oxidoreductase AW166_13435 ENOG4105PAD Hydrolase AW166_13455 ENOG4105DY8 decarboxylase AW166_13470 ENOG4108IUM Glycogen debranching enzyme AW166_13495 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AW166_13505 ENOG4105FDR Membrane AW166_13540 ENOG4108V3A UPF0421 protein AW166_13560 ENOG4105MSI germination protein ypeb AW166_13580 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AW166_13585 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AW166_13590 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AW166_13595 ENOG4107Z3H Transcriptional regulator, TetR family AW166_13625 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AW166_13645 ENOG4105E98 transcriptional regulator DeoR family AW166_13665 ENOG41062ES Transcriptional regulator AW166_13685 ENOG4107QKR Dehydrogenase AW166_13695 ENOG4107RUY (E1 component), alpha subunit AW166_13705 ENOG4105E1F short-chain dehydrogenase reductase AW166_13710 ENOG4105RHY Pfam:UPF0157 AW166_13745 ENOG4107SQ8 Glycine betaine AW166_13750 ENOG4108IJ7 Glycine betaine AW166_13775 ENOG4105E66 phosphoriboisomerase A AW166_13780 ENOG41082BV acetyltransferase AW166_13785 ENOG4108M1A Chitin-binding protein AW166_13830 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AW166_13880 ENOG4105EEM helicase AW166_13900 ENOG4105C9U ATP-dependent DNA helicase RecQ AW166_13955 ENOG4108M1A Chitin-binding protein AW166_13970 ENOG4105BZG amino acid carrier protein AW166_13975 ENOG4105C26 Dehydrogenase AW166_13980 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AW166_13985 ENOG4105CTU Proline racemase AW166_13990 ENOG4105CTU Proline racemase AW166_13995 ENOG41080HI glycine oxidase AW166_14035 ENOG4107T5V SNARE associated Golgi AW166_14050 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AW166_14055 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AW166_14070 ENOG4105DTQ mandelate racemase muconate lactonizing AW166_14110 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AW166_14115 ENOG4105BZU Histidine kinase AW166_14120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW166_14160 ENOG4105EPR degv family AW166_14200 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AW166_14205 ENOG4106K7D Major facilitator family transporter AW166_14225 ENOG4107BMA Transglycosylase associated protein AW166_14240 ENOG41089UC methyltransferase, type 11 AW166_14275 ENOG4105CHM Aminotransferase AW166_14310 ENOG4105DVE abc transporter atp-binding protein AW166_14360 ENOG4105C02 permease AW166_14375 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AW166_14380 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AW166_14385 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AW166_14410 ENOG4105E09 nadh pyrophosphatase AW166_14430 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AW166_14480 ENOG4107VC0 DNA alkylation repair enzyme AW166_14490 ENOG4107VMI polysaccharide deacetylase AW166_14500 ENOG4108ZCF integral membrane protein AW166_14505 ENOG4105E0M Sulfatase AW166_14510 ENOG4105C5H ABC transporter AW166_14520 ENOG4105EYF MMPL domain protein AW166_14525 ENOG4105EYF MMPL domain protein AW166_14530 ENOG4105EYF MMPL domain protein AW166_14535 ENOG41082JN Transcriptional regulator AW166_14555 ENOG4105CIH Imidazole acetol-phosphate transaminase AW166_14560 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AW166_14565 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AW166_14600 ENOG41069ER domain protein AW166_14610 ENOG4105EMN RNA polymerase sigma factor AW166_14635 ENOG4105D4B ABC, transporter AW166_14645 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AW166_14655 ENOG4105DKT Transcriptional regulator AW166_14670 ENOG41061GT Aldolase AW166_14690 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AW166_14720 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AW166_14725 ENOG4105II7 pyrroline-5-carboxylate reductase AW166_14735 ENOG4107258 Transcriptional regulator AW166_14745 ENOG4105E0Y RtcB Protein AW166_14750 ENOG4105ECK Fatty Acid Desaturase AW166_14755 ENOG4105G6Z alkaline phosphatase AW166_14765 ENOG4105VMP Transcriptional regulator AW166_14780 ENOG41090T1 Membrane AW166_14790 ENOG4108WCX response regulator AW166_14800 ENOG41068WN AW166_14825 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AW166_14850 ENOG4105CKK Glycosyl transferase, family 2 AW166_14875 ENOG4105CKK Glycosyl transferase, family 2 AW166_14885 ENOG4105C8Y Acetylornithine aminotransferase AW166_14925 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AW166_14935 ENOG4108TVJ Nitroreductase AW166_14940 ENOG4105FS7 Transcriptional regulator AW166_14975 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AW166_14985 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AW166_15015 ENOG4108XET gCN5-related N-acetyltransferase AW166_15095 ENOG410635A Membrane AW166_15100 ENOG4105KNA -acetyltransferase AW166_15105 ENOG4108IQI permease AW166_15115 ENOG4105F1N DNA alkylation repair AW166_15165 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AW166_15205 ENOG4105P4J Allophanate hydrolase, subunit 1 AW166_15210 ENOG4107258 Transcriptional regulator AW166_15220 ENOG4106N3A copper homeostasis protein cutc AW166_15225 ENOG4108ZRV stage ii sporulation protein p AW166_15230 ENOG4108ZHR arsR family transcriptional regulator AW166_15240 ENOG4105FDT acyl-CoA dehydrogenase AW166_15260 ENOG4105DWD nucleoside recognition domain protein AW166_15290 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AW166_15355 ENOG4105E2A Dehydrogenase AW166_15370 ENOG4108IJ0 Aspartate ammonia-lyase AW166_15375 ENOG4105HDK L-asparaginase AW166_15380 ENOG4108IMY Transcriptional regulator AW166_15390 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AW166_15395 ENOG4105CUB amino acid AW166_15405 ENOG4105II7 pyrroline-5-carboxylate reductase AW166_15415 ENOG4105C6K Malic enzyme AW166_15425 ENOG4108NHD germination protein AW166_15430 ENOG4108NHD germination protein AW166_15455 ENOG4105CSV Glutaminase AW166_15485 ENOG4105CGH 5'-nucleotidase AW166_15490 ENOG4105CH6 catalase AW166_15500 ENOG4105CHJ isochorismatase hydrolase AW166_15560 ENOG4108606 TspO/MBR family AW166_15565 ENOG4105CVP deoxyribo-dipyrimidine photolyase AW166_15580 ENOG4108TWJ NADH dehydrogenase subunit 5 AW166_15585 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AW166_15595 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AW166_15600 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AW166_15605 ENOG4105DSE periplasmic solute binding protein AW166_15610 ENOG4105CC5 ABC transporter AW166_15615 ENOG4105DIK (ABC) transporter AW166_15645 ENOG4105D6J arsenicaL-resistance protein AW166_15650 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AW166_15655 ENOG41085FC arsR family transcriptional regulator AW166_15670 ENOG4105F7F Chaperone AW166_15680 ENOG4105CHR reductase AW166_15685 ENOG4108YXU transcriptional regulator AsnC family AW166_15760 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AW166_15770 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW166_15780 ENOG4105IIP Membrane AW166_15795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW166_15800 ENOG41062D9 Histidine kinase AW166_15830 ENOG4105K6H D-cysteine desulfhydrase AW166_15855 ENOG4105VZ8 Transcriptional regulator AW166_15870 ENOG4108NNI Beta-lactamase domain-containing protein AW166_15875 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AW166_15885 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AW166_15890 ENOG4105JQZ Methyltransferase AW166_15905 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AW166_15910 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AW166_15930 ENOG4105BZU Histidine kinase AW166_15945 ENOG4108U05 Transcriptional regulator AW166_15960 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AW166_15965 ENOG4105DJB Major Facilitator Superfamily AW166_15970 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AW166_15975 ENOG4107QR9 Iron-sulfur cluster binding protein AW166_15985 ENOG4106P55 Transcriptional regulator AW166_15995 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AW166_16030 ENOG4105TRI Hydrolase AW166_16065 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AW166_16095 ENOG4107QJQ Mate efflux family protein AW166_16110 ENOG4105EQ0 Major Facilitator superfamily AW166_16115 ENOG4108JGH Tetr family transcriptional regulator AW166_16130 ENOG4105C44 Serine transporter AW166_16135 ENOG4105EJQ L-serine dehydratase AW166_16150 ENOG4108JPW Aminotransferase AW166_16165 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AW166_16175 ENOG4105DVH amino acid AW166_16190 ENOG4108JQ1 Dehydrogenase AW166_16210 ENOG4108AEY RNA polymerase sigma factor AW166_16225 ENOG41082W1 Cupin 2, conserved barrel domain protein AW166_16235 ENOG410874W AraC family transcriptional regulator AW166_16250 ENOG4105HIR S-layer domain protein AW166_16290 ENOG4108ISG Major Facilitator AW166_16300 ENOG4107MII Sugar-specific transcriptional regulator TrmB AW166_16305 ENOG4105CZM Major Facilitator AW166_16325 ENOG4105DA5 (ABC) transporter AW166_16330 ENOG41069JR AW166_16340 ENOG4105RXJ AW166_16345 ENOG4105KPY Small multidrug resistance protein AW166_16350 ENOG4105KBX Transcriptional regulator, TetR family AW166_16365 ENOG4105CRW Short chain fatty acid transporter AW166_16375 ENOG4105DYS nad(p)h dehydrogenase (quinone) AW166_16405 ENOG4108JJB ABC transporter AW166_16410 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AW166_16435 ENOG4108K8S endonuclease I AW166_16450 ENOG41067QW Transcriptional regulator AW166_16460 ENOG4108Z66 YbaK ebsC protein AW166_16465 ENOG4105CUT histidyl-tRNA synthetase AW166_16480 ENOG4105KVH Transcriptional regulator AW166_16485 ENOG4108RCM Nitroreductase AW166_16505 ENOG4108PSK reductase AW166_16515 ENOG4105CJ1 ABC, transporter AW166_16575 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AW166_16580 ENOG4105DKQ ROK family AW166_16585 ENOG4106UW1 Major Facilitator superfamily AW166_16590 ENOG4108UW5 maltose o-acetyltransferase AW166_16605 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AW166_16610 ENOG4105C31 Tryptophanyl-tRNA synthetase AW166_16615 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AW166_16640 ENOG4105DMQ Methyltransferase AW166_16650 ENOG4105EV4 Multidrug resistance protein mdtH AW166_16680 ENOG4105C37 (CBS) domain AW166_16695 ENOG4105DDN Pentapeptide repeat-containing protein AW166_16700 ENOG4105XDF Protein of unknown function (DUF1272) AW166_16705 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AW166_16710 ENOG4105CMG Carbohydrate kinase AW166_16715 ENOG4105C6Z Gluconate AW166_16720 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AW166_16735 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AW166_16740 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AW166_16745 ENOG4105CIS alcohol dehydrogenase AW166_16750 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AW166_16770 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AW166_16775 ENOG4105D4Y metalloprotease AW166_16795 ENOG4105CV8 reductase AW166_16800 ENOG4105F27 Major Facilitator AW166_16815 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AW166_16820 ENOG4105C44 Serine transporter AW166_16855 ENOG4105KVH Transcriptional regulator AW166_16860 ENOG4108TZY GntR Family Transcriptional Regulator AW166_16870 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AW166_16875 ENOG4105KVH Transcriptional regulator AW166_16880 ENOG4105KVH Transcriptional regulator AW166_16915 ENOG4105JAB phenazine biosynthesis protein, phzf family AW166_16925 ENOG4105CHR reductase AW166_16945 ENOG4105KVH Transcriptional regulator AW166_17015 ENOG4105KAF membrAne AW166_17040 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AW166_17055 ENOG4107YXZ hydrolase, family 25 AW166_17080 ENOG4105ED2 Beta-lactamase AW166_17090 ENOG4105H3G oxidoreductase AW166_17165 ENOG4108TN2 lmbE family AW166_17175 ENOG4107R3E Citrate transporter AW166_17195 ENOG4108MES Periplasmic binding protein AW166_17205 ENOG4105EHG Permease protein AW166_17210 ENOG4105DQ5 transport system permease protein AW166_17215 ENOG4105NX3 Membrane AW166_17220 ENOG4107ZY0 Phenazine biosynthesis-like protein AW166_17240 ENOG4107CUJ Protein of unknown function (DUF2690) AW166_17250 ENOG4107V2S Transcriptional regulator AW166_17270 ENOG4105C98 muts2 protein AW166_17280 ENOG4105E5K Alpha-amylase AW166_17285 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AW166_17290 ENOG4105DPN Oligoendopeptidase f AW166_17295 ENOG4108A04 Beta-lactamase AW166_17325 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AW166_17350 ENOG41082BM Transcriptional regulator, arsr family AW166_17355 ENOG4105CIS alcohol dehydrogenase AW166_17380 ENOG4105RHY Pfam:UPF0157 AW166_17390 ENOG4105C09 Bile acid AW166_17395 ENOG4105CQB FAD linked oxidase domain protein AW166_17420 ENOG4108UT6 Transferase hexapeptide repeat containing protein AW166_17430 ENOG4105K64 Glycosyl transferase, family 2 AW166_17435 ENOG4105E39 Enoyl-CoA hydratase AW166_17445 ENOG4105KT7 mgtC SapB transporter AW166_17455 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AW166_17460 ENOG41073R8 VanW family AW166_17470 ENOG4108R1P AW166_17490 ENOG4105VEQ Cold shock protein AW166_17510 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AW166_17530 ENOG410904N short-chain dehydrogenase reductase AW166_17540 ENOG4106IQC argininosuccinate lyase AW166_17555 ENOG4108IA2 Sodium pantothenate symporter AW166_17560 ENOG4105RG0 Membrane AW166_17565 ENOG4105C26 Dehydrogenase AW166_17570 ENOG4105CHR reductase AW166_17580 ENOG4105EWU Squalene--hopene cyclase AW166_17590 ENOG4105FR1 rard protein AW166_17595 ENOG410696E Membrane AW166_17610 ENOG4105D1F ATP-binding protein AW166_17620 ENOG4108ZAF Molybdopterin AW166_17625 ENOG4105CVM Molybdenum cofactor synthesis domain protein AW166_17630 ENOG4105D06 uba thif-type nad fad binding protein AW166_17635 ENOG4105TMB Formate nitrite transporter AW166_17645 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AW166_17650 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AW166_17660 ENOG4108JB9 formate dehydrogenase AW166_17670 ENOG4105E1K spore germination protein AW166_17735 ENOG4108KGH TRANSCRIPTIONal AW166_17745 ENOG4105EMN RNA polymerase sigma factor AW166_17770 ENOG4105CIG ABC transporter AW166_17780 ENOG4105D9R oxidoreductase AW166_17790 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW166_17800 ENOG4105K4P CoA-binding domain protein AW166_17805 ENOG4105C0H protease AW166_17810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW166_17820 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AW166_17825 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AW166_17830 ENOG4105W8X HesB YadR YfhF-family protein AW166_17860 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AW166_17865 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AW166_17875 ENOG4108JJA ABC, transporter AW166_17880 ENOG4108I0Z Aconitate hydratase AW166_17910 ENOG4105E5W Transporter AW166_17920 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AW166_17940 ENOG4107F3J Amp-dependent synthetase and ligase AW166_17945 ENOG4107ZYJ bioY protein AW166_17950 ENOG4105CEY Amp-dependent synthetase and ligase AW166_17995 ENOG4107AYK membrAne AW166_18005 ENOG4105BZU Histidine kinase AW166_18010 ENOG4105FBA Phospholipase Carboxylesterase AW166_18015 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AW166_18020 ENOG4105CK7 Sodium proline symporter AW166_18025 ENOG4105CBC glutamate synthase AW166_18030 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AW166_18035 ENOG4108VJ1 Transcriptional regulator (CarD family AW166_18040 ENOG4108903 Formimidoylglutamase AW166_18065 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AW166_18125 ENOG4107QIV Cytochrome c biogenesis protein AW166_18135 ENOG4107RSM transcriptional regulator AW166_18140 ENOG4105VAW lrga family AW166_18145 ENOG41067MG lrgb family AW166_18170 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW166_18185 ENOG4105BZ1 (ABC) transporter AW166_18190 ENOG4105BZ1 (ABC) transporter AW166_18210 ENOG4105D7V transposase AW166_18230 ENOG4105D5T phosphonate abc transporter AW166_18245 ENOG4105CGH 5'-nucleotidase AW166_18255 ENOG4108SVB resolvase AW166_18275 ENOG4105K7K Transcriptional regulator AW166_18310 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AW166_18315 ENOG4105XSJ toxin secretion phage lysis holin AW166_18525 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) AW166_18630 ENOG4105C5F glutamine synthetase AW166_18635 ENOG4105KV4 Transcriptional regulator AW166_18640 ENOG4105CXI aluminum resistance protein AW166_18650 ENOG4105EN6 Membrane AW166_18655 ENOG4106F1P AAA ATPase, central domain protein AW166_18685 ENOG41069ER domain protein AW166_18690 ENOG4105DM4 PTS System AW166_18695 ENOG4105DE4 1-phosphofructokinase AW166_18700 ENOG4105E98 transcriptional regulator DeoR family AW166_18710 ENOG4108SJC Membrane AW166_18725 ENOG4105C85 amino acid AW166_18740 ENOG4105TMB Formate nitrite transporter AW166_18745 ENOG4105K70 DNA-binding protein AW166_18750 ENOG4105C59 p-type ATPase AW166_18755 ENOG410681U heavy metal transport detoxification protein AW166_18760 ENOG4105VPX protein, conserved in bacteria AW166_18770 ENOG4105NIV Esterase AW166_18775 ENOG4105E0A ABC, transporter AW166_18800 ENOG4105CGK Exodeoxyribonuclease III AW166_18810 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AW166_18815 ENOG4105D03 DNA-3-methyladenine glycosylase II AW166_18845 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AW166_18850 ENOG4105BZU Histidine kinase AW166_18870 ENOG41067MG lrgb family AW166_18885 ENOG4107TTQ Alpha beta hydrolase fold AW166_18890 ENOG4107YEI lmbE family AW166_18910 ENOG4105F0V Cell wall hydrolase AW166_18915 ENOG4107R6R udp-galactopyranose mutase AW166_18920 ENOG4105E0M Sulfatase AW166_18925 ENOG410890F Dynamin family AW166_18935 ENOG4107QHE Choloylglycine hydrolase AW166_18960 ENOG4105DA5 (ABC) transporter AW166_18985 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AW166_18990 ENOG4105DQU oxidoreductase, subunit beta AW166_18995 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AW166_19000 ENOG4108IGT Dipeptidase AW166_19005 ENOG4105MCT stage V sporulation protein S AW166_19010 ENOG4105D48 metallophosphoesterase AW166_19035 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AW166_19050 ENOG4105XZV Protein of unknown function (DUF3243) AW166_19055 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AW166_19075 ENOG4105UIB (ABC) transporter AW166_19080 ENOG4105UIB (ABC) transporter AW166_19085 ENOG4108JQ9 ABC transporter AW166_19090 ENOG4105DIH basic membrane AW166_19095 ENOG4105FDP GntR family transcriptional regulator AW166_19100 ENOG4107QZI cell division protein FtsK AW166_19110 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AW166_19125 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AW166_19135 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AW166_19140 ENOG4108S0H Dipicolinic acid synthetase, b subunit AW166_19145 ENOG4105E35 Dipicolinate synthase subunit A AW166_19155 ENOG4105C1V Peptidase, M16 AW166_19175 ENOG4105DTN riboflavin biosynthesis protein ribF AW166_19180 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AW166_19190 ENOG4105W7A Protein of unknown function (DUF503) AW166_19200 ENOG4105VHM ribosomal protein AW166_19205 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AW166_19210 ENOG4105CHV Transcription elongation factor NusA AW166_19220 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AW166_19230 ENOG4105DZP Membrane-associated zinc metalloprotease AW166_19235 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AW166_19240 ENOG4105KNE Phosphatidate cytidylyltransferase AW166_19245 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AW166_19285 ENOG4108HE4 integrase family AW166_19295 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AW166_19305 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AW166_19320 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AW166_19345 ENOG4105VB6 UPF0109 protein AW166_19365 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AW166_19370 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AW166_19385 ENOG4105CHR reductase AW166_19390 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AW166_19405 ENOG4105CB5 ATP-dependent DNA helicase recG AW166_19410 ENOG4105DP4 dak2 domain fusion protein ylov AW166_19415 ENOG4108ZAA Alkaline-shock protein AW166_19430 ENOG4105FJ0 thiamine AW166_19435 ENOG4105DJV ribulose-phosphate 3-epimerase AW166_19440 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AW166_19445 ENOG4105D9P serine threonine protein kinase AW166_19450 ENOG4108ZF3 Phosphatase AW166_19460 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AW166_19470 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AW166_19475 ENOG4105C25 Primosomal protein n' AW166_19480 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AW166_19500 ENOG4105DSJ YicC domain protein AW166_19510 ENOG4105F23 Fibronectin-binding protein AW166_19515 ENOG4105DC7 peptidase M24 AW166_19570 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AW166_19595 ENOG4105C34 Pseudouridine synthase AW166_19610 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AW166_19620 ENOG4105DBK s4 domain protein AW166_19625 ENOG41067XK integral membrane protein AW166_19635 ENOG4105DFA alanine racemase domain protein AW166_19640 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AW166_19645 ENOG4105WR5 sporulation protein, YlmC YmxH family AW166_19655 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW166_19665 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AW166_19670 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AW166_19675 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AW166_19680 ENOG4105D4A Cell wall formation (By similarity) AW166_19685 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AW166_19690 ENOG4105CNI cell division protein FtsW AW166_19705 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AW166_19710 ENOG4105CJN penicillin-binding protein AW166_19715 ENOG4105CJN penicillin-binding protein AW166_19720 ENOG41068DC Essential cell division protein (By similarity) AW166_19755 ENOG4105KNH Nucleic acid-binding protein AW166_19805 ENOG4105XSJ toxin secretion phage lysis holin AW166_19890 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AW166_19900 ENOG4105CAR Terminase, large subunit AW166_19990 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AW166_20000 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW166_20055 ENOG4108IMY Transcriptional regulator AW166_20080 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) AW166_20090 ENOG41063PX domain protein AW166_20095 ENOG4105D78 K07001 NTE family protein AW166_20100 ENOG4105H20 Sporulation integral membrane protein YlbJ AW166_20110 ENOG4106H78 methyltransferase AW166_20130 ENOG4107TB6 phosphoglycerate mutase AW166_20145 ENOG4106UY4 Inherit from COG: Scp-like extracellular AW166_20195 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AW166_20200 ENOG4105CNI cell division protein FtsW AW166_20215 ENOG4108IAB Phoh family AW166_20235 ENOG4105QA2 AW166_20240 ENOG4105CI3 gtp-binding protein typa AW166_20250 ENOG4105ECY inositol monophosphatase AW166_20270 ENOG4105CXN decarboxylase AW166_20315 ENOG4105C7S Dehydrogenase AW166_20320 ENOG4105CPP Dehydrogenase, E1 component AW166_20335 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AW166_20340 ENOG4108X4Q Hydrolase AW166_20350 ENOG4105CN5 Metallo-Beta-Lactamase AW166_20355 ENOG4107ZYR domain protein AW166_20390 ENOG4108XRC Protein of unknown function (DUF458) AW166_20400 ENOG4107IN1 Protein of unknown function (DUF1797) AW166_20415 ENOG4105EPM Diguanylate phosphodiesterase AW166_20420 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AW166_20435 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AW166_20445 ENOG4105UIN AW166_20505 ENOG4108HGU Histidine kinase AW166_20515 ENOG4105CHM Aminotransferase AW166_20520 ENOG4105FKQ transcriptional regulator AW166_20525 ENOG4105EG2 ABC transporter, permease AW166_20535 ENOG4107FKK extracellular solute-binding protein family 1 AW166_20545 ENOG4105CG3 alpha amylase, catalytic region AW166_20590 ENOG4105CHU acetyl-coa acetyltransferase AW166_20630 ENOG4105K7K Transcriptional regulator AW166_20635 ENOG4105DTD Dehydrogenase AW166_20645 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AW166_20655 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AW166_20680 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AW166_20700 ENOG4106TD9 Diguanylate cyclase AW166_20720 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AW166_20735 ENOG4105CID antiterminator AW166_20745 ENOG4105FDP GntR family transcriptional regulator AW166_20755 ENOG4105CE4 GlcNAc 6-P deacetylase AW166_20800 ENOG4107ZE5 PPIases accelerate the folding of proteins AW166_20805 ENOG4105PTM secreted protein AW166_20810 ENOG4105J7I hydrolase AW166_20820 ENOG4105G6R Stage v sporulation protein ae AW166_20830 ENOG4105CZ3 stage V sporulation protein ad AW166_20835 ENOG41090VF Stage v sporulation protein ac AW166_20855 ENOG4105C8J )-transporter AW166_20860 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW166_20870 ENOG41082AN stage II sporulation protein AW166_20875 ENOG4105DZ1 carboxypeptidase AW166_20880 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AW166_20885 ENOG4105DVE abc transporter atp-binding protein AW166_20920 ENOG4105D7N magnesium and cobalt transport protein CorA AW166_20945 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW166_20955 ENOG4105I3K Ferric uptake regulator, Fur family AW166_20960 ENOG4105MZ9 stage II sporulation protein m AW166_20980 ENOG4105CPC Aldo Keto reductase AW166_20990 ENOG4105RHY Pfam:UPF0157 AW166_21010 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AW166_21020 ENOG4105ETE Transcriptional regulator (LacI family AW166_21025 ENOG4108YM7 Gcn5-related n-acetyltransferase AW166_21045 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AW166_21050 ENOG4108R6K riboflavin synthase, subunit alpha AW166_21070 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AW166_21075 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AW166_21080 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AW166_21085 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AW166_21095 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW166_21105 ENOG4105DFD Na H antiporter AW166_21110 ENOG4105CGH 5'-nucleotidase AW166_21150 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AW166_21165 ENOG4108IXY short-chain dehydrogenase reductase AW166_21170 ENOG41069FQ Metallo-beta-lactamase superfamily AW166_21180 ENOG4105II7 pyrroline-5-carboxylate reductase AW166_21185 ENOG4105EJQ L-serine dehydratase AW166_21210 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AW166_21220 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AW166_21225 ENOG4105D9U N-acetyltransferase AW166_21240 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AW166_21245 ENOG4108QEG Membrane AW166_21250 ENOG4105CDA abc transporter atp-binding protein AW166_21255 ENOG4105E5Q amino acid AbC transporter AW166_21260 ENOG4108HW3 (ABC) transporter AW166_21270 ENOG4105G7B Protein of unknown function (DUF2992) AW166_21290 ENOG4105C7S Dehydrogenase AW166_21295 ENOG4105CPP Dehydrogenase, E1 component AW166_21315 ENOG4107RDP Dehydrogenase AW166_21330 ENOG4108JUB Transcriptional regulator AW166_21340 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AW166_21355 ENOG4107QQR Sporulation AW166_21365 ENOG4105S1Z Stage IV sporulation protein B AW166_21370 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AW166_21380 ENOG4105DX0 Hemolysin A AW166_21390 ENOG4105CTB Polyprenyl synthetase AW166_21415 ENOG4108ZSR alkaline shock protein AW166_21420 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AW166_21445 ENOG410644B Stage III sporulation protein af AW166_21455 ENOG4105KQ4 Stage iii sporulation protein ad AW166_21460 ENOG4108CQH stage III sporulation protein AC AW166_21465 ENOG4105KR5 Stage iii sporulation protein AW166_21470 ENOG4105CD2 stage iii sporulation protein aa AW166_21495 ENOG4105DC7 peptidase M24 AW166_21510 ENOG4105CBJ Metal-dependent enzyme AW166_21520 ENOG4107YBY Hydrolase AW166_21540 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AW166_21545 ENOG4105WZW rhodanese family AW166_21565 ENOG41080TC multidrug resistance protein AW166_21605 ENOG4105CJ1 ABC, transporter AW166_21610 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AW166_21640 ENOG4105C0D helicase AW166_21760 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AW166_21765 ENOG4105C3R Methionine synthase AW166_21775 ENOG4105C28 cystathionine AW166_21780 ENOG4105C28 cystathionine AW166_21805 ENOG4105C5X domain protein AW166_21815 ENOG4105DKQ ROK family AW166_21825 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AW166_21840 ENOG4108UTW Plays a role in the regulation of phosphate uptake AW166_21845 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AW166_21850 ENOG4105E2Z phosphate ABC transporter (Permease AW166_21855 ENOG4105C8U phosphate abc transporter AW166_21860 ENOG4105PWN phosphate abc transporter AW166_21865 ENOG4107RF6 penicillin-binding protein AW166_21875 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW166_21900 ENOG4105N80 Ferric uptake regulator, Fur family AW166_21910 ENOG4105FDK ABC transporter AW166_21915 ENOG4108JYZ YitT family AW166_21920 ENOG41069ZM Protein of unknown function (DUF2624) AW166_21945 ENOG4105EGD dinuclear metal center protein, YbgI family AW166_21960 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW166_21965 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AW166_22000 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AW166_22005 ENOG4105KG3 cytidine deaminase AW166_22010 ENOG4107YR5 Diacylglycerol kinase AW166_22020 ENOG4105CTJ Metal Dependent Phosphohydrolase AW166_22025 ENOG4105C9A Phoh family AW166_22040 ENOG41068P3 sporulation protein YqfC AW166_22045 ENOG4105KTH gatB Yqey AW166_22055 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AW166_22060 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AW166_22080 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AW166_22090 ENOG4105CSA Coproporphyrinogen iii oxidase AW166_22095 ENOG4105KVH Transcriptional regulator AW166_22120 ENOG4105TQK DNA polymerase iii, delta' subunit AW166_22130 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AW166_22135 ENOG4108UK2 deaminase AW166_22140 ENOG4105KQC Competence protein AW166_22150 ENOG4105DXX methyltransferase AW166_22160 ENOG4108WF2 Metal Dependent Phosphohydrolase AW166_22170 ENOG410812S Rna-binding protein AW166_22180 ENOG4105CQW ribosome biogenesis GTPase YqeH AW166_22185 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AW166_22200 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW166_22220 ENOG4108TVJ Nitroreductase AW166_22235 ENOG4105G6Z alkaline phosphatase AW166_22245 ENOG4108MUZ hydrolase AW166_22280 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AW166_22285 ENOG4105MIR Phenylalanine 4-monooxygenase AW166_22295 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AW166_22300 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AW166_22340 ENOG4105S6R Iron-hydroxamate transporter permease subunit AW166_22345 ENOG4108V5C ABC transporter AW166_22355 ENOG4108EKI Dehydrogenase AW166_22360 ENOG4105C28 cystathionine AW166_22390 ENOG4107XRG penicillin-binding protein AW166_22405 ENOG4105CFP Peptidase U32 AW166_22410 ENOG4105XYU peptidase (U32 family) AW166_22415 ENOG4108VQJ O-methyltransferase AW166_22420 ENOG4105HHA aminodeoxychorismate lyase AW166_22440 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AW166_22450 ENOG4105C02 permease AW166_22465 ENOG41060CR AW166_22470 ENOG4105C7H Helicase, RecD TraA family AW166_22480 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AW166_22485 ENOG4105C3J Cysteine desulfurase AW166_22495 ENOG4105D1H recombination factor protein RarA AW166_22500 ENOG4108VCI transcription factor, rsfa family AW166_22505 ENOG4105CUZ uba thif-type nad fad binding protein AW166_22515 ENOG4105CUT histidyl-tRNA synthetase AW166_22530 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AW166_22540 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AW166_22545 ENOG41076HS cation diffusion facilitator family transporter AW166_22550 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AW166_22560 ENOG4105CKP Polysaccharide Biosynthesis Protein AW166_22565 ENOG4108QG2 Membrane AW166_22575 ENOG4105VIE preprotein translocase, subunit YajC AW166_22590 ENOG41061AI Protein of unknown function (DUF2905) AW166_22605 ENOG4108HUF Transporter AW166_22615 ENOG4108IPJ Membrane AW166_22620 ENOG4108IPJ Membrane AW166_22625 ENOG41082BM Transcriptional regulator, arsr family AW166_22650 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AW166_22655 ENOG4108IYU L-aspartate oxidase AW166_22670 ENOG4108RPX mosc domain containing protein AW166_22675 ENOG4105CQC Prephenate dehydratase AW166_22695 ENOG4105EWM Histidine kinase AW166_22710 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AW166_22725 ENOG4105X36 (ribosomal) protein AW166_22735 ENOG4105C03 ribonuclease AW166_22750 ENOG4107QMS site-determining protein AW166_22765 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AW166_22770 ENOG4105DFF Rod shape-determining protein mreb AW166_22790 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AW166_22795 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AW166_22805 ENOG41068KH stage VI sporulation protein D AW166_22815 ENOG4105D52 delta-aminolevulinic acid dehydratase AW166_22840 ENOG4105K56 Transcriptional regulator AW166_22860 ENOG4108IUQ atp-dependent protease AW166_22890 ENOG4108QCI YvbH-like oligomerisation region AW166_22915 ENOG4105M59 Phosphodiesterase, mj0936 family AW166_22920 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AW166_22930 ENOG4108XJQ germination protein AW166_22940 ENOG4108PCX Major Facilitator AW166_22950 ENOG4105KBX Transcriptional regulator, TetR family AW166_22965 ENOG4105PFC Transcriptional regulator AW166_22980 ENOG4105DZC cytosine deaminase AW166_22985 ENOG4105DZC cytosine deaminase AW166_22990 ENOG4105DEF Extracellular solute-binding protein, family 5 AW166_22995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW166_23010 ENOG4108JQ7 (ABC) transporter AW166_23015 ENOG4108HRK Histidine kinase AW166_23020 ENOG4105DY9 regulatoR AW166_23035 ENOG41067S9 phage shock protein C, PspC AW166_23040 ENOG4108JCI Transcriptional regulator AW166_23050 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AW166_23055 ENOG4108Z40 Transcriptional regulator AW166_23060 ENOG4105RHA ABC transporter, permease AW166_23065 ENOG4108IUX (ABC) transporter AW166_23070 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AW166_23080 ENOG4105E14 MotA TolQ exbB proton channel AW166_23085 ENOG4108VXD carboxy-peptidase AW166_23095 ENOG4105E33 succinate dehydrogenase AW166_23105 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AW166_23120 ENOG4105K63 Thioredoxin AW166_23125 ENOG4105C10 Electron transfer flavoprotein AW166_23130 ENOG4105BZJ Electron transfer flavoprotein AW166_23135 ENOG41060WC Enoyl-CoA hydratase AW166_23140 ENOG4107Z3H Transcriptional regulator, TetR family AW166_23145 ENOG4105CEY Amp-dependent synthetase and ligase AW166_23155 ENOG4105J76 Periplasmic binding protein AW166_23160 ENOG4105S6R Iron-hydroxamate transporter permease subunit AW166_23205 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW166_23220 ENOG4105DR4 Methyltransferase AW166_23235 ENOG4105KFN sortase, SrtB family AW166_23240 ENOG4105E0A ABC, transporter AW166_23255 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AW166_23265 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AW166_23275 ENOG4105FE9 pseudouridine synthase AW166_23290 ENOG4105DCG PHP domain protein AW166_23325 ENOG4105C5S asparaginyl-tRNA synthetase AW166_23330 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AW166_23340 ENOG4108RWN rrna methyltransferase AW166_23375 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW166_23380 ENOG4105CW7 secretion protein, HlyD family AW166_23385 ENOG4108JGH Tetr family transcriptional regulator AW166_23390 ENOG4105CN9 Peptidase m42 family protein AW166_23410 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AW166_23415 ENOG4105C22 threonyL-tRNA synthetase AW166_23420 ENOG4108TDW sporulation protein YtxC AW166_23440 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AW166_23445 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AW166_23450 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AW166_23460 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AW166_23465 ENOG4105C2M dna polymerase I AW166_23470 ENOG4105BZU Histidine kinase AW166_23475 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW166_23495 ENOG4108HMX isocitrate dehydrogenase (NADP) AW166_23500 ENOG4105BZN citrate synthase AW166_23515 ENOG4108REF Sporulation integral membrane protein ytvi AW166_23520 ENOG4105FS0 cytoplasmic membrane protein AW166_23545 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AW166_23550 ENOG4105C6K Malic enzyme AW166_23555 ENOG4105C0B DNA polymerase III (alpha subunit) AW166_23560 ENOG4105VV2 AW166_23570 ENOG4105SFS phosphoesterase RecJ domain protein AW166_23605 ENOG4105DC7 peptidase M24 AW166_23640 ENOG4105Z7P Acetyltransferase (GNAT) family AW166_23645 ENOG41082W1 Cupin 2, conserved barrel domain protein AW166_23655 ENOG4105VZ8 Transcriptional regulator AW166_23675 ENOG4107YZX Universal stress protein AW166_23715 ENOG4108JYZ YitT family AW166_23735 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AW166_23745 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AW166_23750 ENOG4105KBJ sporulation protein ytfj AW166_23765 ENOG4105EFZ amidohydrolase AW166_23775 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AW166_23800 ENOG4106KR7 LysR family Transcriptional regulator AW166_23820 ENOG4105C28 cystathionine AW166_23840 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AW166_23850 ENOG4105EMN RNA polymerase sigma factor AW166_23865 ENOG4105F1V Acetoin utilization protein AW166_23870 ENOG4105W87 Cbs domain AW166_23875 ENOG4105DGU Histone deacetylase AW166_23885 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW166_23895 ENOG4107SNB ankyrin repeat protein YahD AW166_23900 ENOG4105EP9 oxidoreductase AW166_23930 ENOG4105ETE Transcriptional regulator (LacI family AW166_23955 ENOG4105C88 aminopeptidase AW166_24000 ENOG4108VDD TRNA binding domain protein AW166_24030 ENOG4105C8F Beta-lactamase domain protein AW166_24045 ENOG4108V15 phosphotransferase enzyme family AW166_24050 ENOG4108IUM Glycogen debranching enzyme AW166_24065 ENOG4107QSE Dipeptidase AW166_24070 ENOG4107QSE Dipeptidase AW166_24075 ENOG4105YW5 deoR family transcriptional regulator AW166_24090 ENOG4105CBX hi0933 family AW166_24125 ENOG4108VJ1 Transcriptional regulator (CarD family AW166_24130 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AW166_24135 ENOG4105CSC Glucose uptake protein AW166_24150 ENOG4108ZAF Molybdopterin AW166_24155 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AW166_24160 ENOG4105CVM Molybdenum cofactor synthesis domain protein AW166_24170 ENOG4105D06 uba thif-type nad fad binding protein AW166_24195 ENOG41085GJ domain protein AW166_24205 ENOG4105DWV Homoserine O-trans-acetylase AW166_24215 ENOG4108B31 Spore germination protein AW166_24250 ENOG410605W Major Facilitator AW166_24255 ENOG4107S91 Sodium hydrogen exchanger AW166_24260 ENOG4105NCW Trka-c domain protein AW166_24275 ENOG4105C19 ABC transporter AW166_24295 ENOG4105N5T Radical SAM Protein AW166_24305 ENOG4105DA5 (ABC) transporter AW166_24335 ENOG4105E8V Alpha Beta Hydrolase Fold protein AW166_24340 ENOG4108Z0R Transferase AW166_24345 ENOG4105YVM Phosphoesterase, PA-phosphatase related AW166_24350 ENOG4105BZF Glycosyl transferase (Group 1 AW166_24360 ENOG4108RIR Molybdenum cofactor biosynthesis protein AW166_24415 ENOG4105EGD dinuclear metal center protein, YbgI family AW166_24420 ENOG4105BZU Histidine kinase AW166_24425 ENOG4105BZU Histidine kinase AW166_24430 ENOG4107S9D Alpha beta hydrolase AW166_24450 ENOG4105D2X ABC transporter substrate-binding protein AW166_24460 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AW166_24515 ENOG4108V2W Carbonate dehydratase AW166_24520 ENOG4105C4M (Ubiquinol oxidase) subunit I AW166_24525 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AW166_24570 ENOG41087YS Phage shock protein A AW166_24605 ENOG4105BZU Histidine kinase AW166_24610 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW166_24635 ENOG4108UGV hypoxanthine phosphoribosyltransferase AW166_24640 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AW166_24675 ENOG4107ZTW SNARE associated Golgi AW166_24690 ENOG4105C19 ABC transporter AW166_24695 ENOG41086D8 Transcriptional regulator AW166_24740 ENOG4105C6Z Gluconate AW166_24745 ENOG4105FDP GntR family transcriptional regulator AW166_24765 ENOG41069H0 dihydroorotase EC 3.5.2.3 AW166_24795 ENOG4105DTQ mandelate racemase muconate lactonizing AW166_24805 ENOG4108IPT Naphthoate synthase AW166_24810 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AW166_24815 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AW166_24820 ENOG4105E4F Isochorismate synthase AW166_24825 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AW166_24835 ENOG4105VEQ Cold shock protein AW166_24860 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AW166_24870 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AW166_24880 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AW166_24975 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AW166_25010 ENOG4105KT7 mgtC SapB transporter AW166_25015 ENOG4107PBV potassium channel AW166_25025 ENOG4107QYV phosphohexose isomerase AW166_25035 ENOG4105WG9 Conserved Protein AW166_25045 ENOG4105CHM Aminotransferase AW166_25050 ENOG4108ZB6 transcriptional regulator AsnC family AW166_25055 ENOG4105C5I Dehydrogenase AW166_25060 ENOG4108MUZ hydrolase AW166_25070 ENOG4105C87 Aminotransferase class I and II AW166_25085 ENOG4105Y38 Kinase-associated protein B AW166_25095 ENOG4107R3E Citrate transporter AW166_25110 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AW166_25115 ENOG4105KA0 thioesterase Superfamily protein AW166_25135 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AW166_25155 ENOG41069ER domain protein AW166_25170 ENOG4105CEP NADH dehydrogenase AW166_25200 ENOG4105EWC Purine nucleoside phosphorylase AW166_25220 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AW166_25245 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AW166_25250 ENOG4105C4B ABC transporter, permease AW166_25255 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AW166_25300 ENOG41083MR nifu domain-containing protein AW166_25315 ENOG4108W5N phosphatidylglycerophosphatase a AW166_25330 ENOG4105DYS nad(p)h dehydrogenase (quinone) AW166_25335 ENOG4105D4U had-superfamily hydrolase, subfamily iia AW166_25350 ENOG4105CBT Fructose-1,6-bisphosphatase AW166_25370 ENOG4105MMD transcriptional regulator AW166_25375 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AW166_25380 ENOG4107TXC Transcriptional regulator AW166_25385 ENOG41090T1 Membrane AW166_25410 ENOG4105FAA peptidase M23 AW166_25420 ENOG4105KZD Domain of unknown function (DUF1805) AW166_25425 ENOG4107R8B 5'-nucleotidase AW166_25450 ENOG4105DIW FeS assembly protein SUFB AW166_25455 ENOG4108UNV SUF system FeS assembly protein, NifU family AW166_25460 ENOG4105C9B Cysteine desulfurase AW166_25465 ENOG4105JRK feS assembly protein SufD AW166_25470 ENOG4105C3K feS assembly ATPase SufC AW166_25475 ENOG4105D01 (LipO)protein AW166_25480 ENOG4105D01 (LipO)protein AW166_25485 ENOG4108UMI ABC transporter, permease AW166_25520 ENOG41080E8 Transcriptional regulator, Spx MgsR family AW166_25570 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AW166_25595 ENOG4108W8B Beta-lactamase domain protein AW166_25600 ENOG4105C1G acyl-Coa dehydrogenase AW166_25610 ENOG4105CHU acetyl-coa acetyltransferase AW166_25625 ENOG4105DZ1 carboxypeptidase AW166_25645 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AW166_25665 ENOG4108SUT Major Facilitator Superfamily AW166_25670 ENOG4107R7I amino acid AW166_25680 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AW166_25690 ENOG4107AYK membrAne AW166_25725 ENOG4107ZTW SNARE associated Golgi AW166_25735 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AW166_25740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW166_25745 ENOG4105BZU Histidine kinase AW166_25755 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AW166_25770 ENOG4105VG1 fes assembly suf system protein AW166_25775 ENOG4105D4Y metalloprotease AW166_25795 ENOG4107S91 Sodium hydrogen exchanger AW166_25800 ENOG4105NCW Trka-c domain protein AW166_25815 ENOG4108RMU ferritin dps family protein AW166_25830 ENOG4108URH decarboxylase AW166_25855 ENOG4105D9N nucleoside AW166_25860 ENOG4105D9N nucleoside AW166_25875 ENOG4108RYK Nad-dependent epimerase dehydratase AW166_25890 ENOG4105CV8 reductase AW166_25895 ENOG4105F27 Major Facilitator AW166_25900 ENOG4105KVH Transcriptional regulator AW166_25915 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AW166_25920 ENOG4105D4A Cell wall formation (By similarity) AW166_25930 ENOG4105C8Q Methyl-accepting chemotaxis AW166_25940 ENOG4105WMR Protein CrcB homolog AW166_25945 ENOG4105WMR Protein CrcB homolog AW166_25960 ENOG4108MK9 spermidine N(1)-acetyltransferase AW166_25965 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AW166_25980 ENOG4108IPW abc transporter atp-binding protein AW166_25985 ENOG4105CM4 permease protein AW166_26015 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AW166_26025 ENOG4105XZU Preprotein translocase, subunit SecG AW166_26030 ENOG41067MG lrgb family AW166_26130 ENOG4105EFC phage portal protein HK97 family AW166_26155 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW166_26165 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AW166_26170 ENOG4105CP7 Triose-phosphate isomerase AW166_26195 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW166_26215 ENOG41090VF Stage v sporulation protein ac AW166_26220 ENOG4105CZ3 stage V sporulation protein ad AW166_26235 ENOG4105H67 Protein of unknown function (DUF421) AW166_26240 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AW166_26245 ENOG4105KRI phosphocarrier protein (HPr AW166_26255 ENOG4105CHW UPF0052 protein AW166_26265 ENOG4108Z4K mutator MutT protein AW166_26275 ENOG4105C3M thioredoxin reductase AW166_26285 ENOG4108S4C acetyltransferase AW166_26305 ENOG41086DT Membrane protein of unknown function AW166_26315 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AW166_26320 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AW166_26325 ENOG4105D7V transposase AW166_26340 ENOG4107TXC Transcriptional regulator AW166_26365 ENOG4105HMI Membrane AW166_26370 ENOG4105DUM transcriptional regulator, lysR family AW166_26380 ENOG4108WS4 fmn reductase AW166_26395 ENOG4105BZ1 (ABC) transporter AW166_26405 ENOG4105CN1 protease AW166_26410 ENOG4105CRP Part of the ABC transporter FtsEX involved in AW166_26415 ENOG4105CAK Cell division ATP-binding protein ftsE AW166_26430 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AW166_26435 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AW166_26440 ENOG4105MS2 ribosomal subunit Interface protein AW166_26445 ENOG4105VEQ Cold shock protein AW166_26450 ENOG41081UC Inherit from COG: Competence protein AW166_26465 ENOG4105KVH Transcriptional regulator AW166_26480 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AW166_26485 ENOG4108KGH TRANSCRIPTIONal AW166_26490 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AW166_26495 ENOG4105C6Y Udp-glucose 6-dehydrogenase AW166_26500 ENOG4105ESV Glycosyl transferase, family 4 AW166_26510 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AW166_26525 ENOG410901P UPF0249 protein AW166_26530 ENOG4105F8D glycoside hydrolase family 4 AW166_26535 ENOG4105VCP PTS System AW166_26540 ENOG4105CK1 PTS System AW166_26550 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AW166_26555 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AW166_26560 ENOG4105VCP PTS System AW166_26570 ENOG4105VZJ PTS System AW166_26585 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AW166_26590 ENOG4105ECB domain protein AW166_26595 ENOG4107RSM transcriptional regulator AW166_26640 ENOG4105DAA L-lactate AW166_26650 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AW166_26660 ENOG4105E0M Sulfatase AW166_26695 ENOG4105C94 Transporter AW166_26700 ENOG41069ER domain protein AW166_26725 ENOG4105KBK Zinc finger, swim domain protein AW166_26730 ENOG4105C0D helicase AW166_26760 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW166_26770 ENOG4107RBB ABC transporter, permease AW166_26775 ENOG4105C19 ABC transporter AW166_26795 ENOG4105CXY transporter AW166_26810 ENOG4105BZU Histidine kinase AW166_26815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW166_26820 ENOG4105CMR udp-glucose 4-epimerase AW166_26835 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AW166_26840 ENOG4105EY8 ABC transporter AW166_26895 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AW166_26910 ENOG4105FRN stage II sporulation protein AW166_26925 ENOG4105DY9 regulatoR AW166_26930 ENOG4108IUW ABC transporter AW166_26950 ENOG4106778 Protein of unknown function (DUF1146) AW166_26955 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AW166_26960 ENOG4105C8S subunit m AW166_26965 ENOG4105D65 subunit l AW166_26990 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AW166_26995 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AW166_27005 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AW166_27010 ENOG4105BZU Histidine kinase AW166_27060 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AW166_27065 ENOG41062M3 atp synthase AW166_27095 ENOG4108YZG isomerase AW166_27110 ENOG4108VGI doxx family AW166_27115 ENOG4107XC4 flavin reductase domain protein, FMN-binding AW166_27130 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AW166_27140 ENOG4108ZXQ stage ii sporulation protein r AW166_27145 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AW166_27150 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AW166_27165 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AW166_27170 ENOG4105CBT Fructose-1,6-bisphosphatase AW166_27175 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AW166_27210 ENOG4105C1G acyl-Coa dehydrogenase AW166_27215 ENOG4105C1G acyl-Coa dehydrogenase AW166_27220 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AW166_27230 ENOG4105DF6 Fe-S oxidoreductase AW166_27245 ENOG4105BZU Histidine kinase AW166_27265 ENOG4105BZU Histidine kinase AW166_27270 ENOG4105KCT ABC transporter AW166_27275 ENOG4108M15 ABC transporter AW166_27280 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AW166_27300 ENOG4105IIU Aminopeptidase AW166_27320 ENOG4105EMN RNA polymerase sigma factor AW166_27330 ENOG410684U Domain of unknown function (DUF1934) AW166_27355 ENOG4105CYW agmatinase AW166_27365 ENOG4105DXB Major Facilitator superfamily AW166_27370 ENOG4107SWG transcriptional regulator MERR family AW166_27375 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AW166_27380 ENOG4105BZ4 penicillin-binding protein AW166_27385 ENOG4108XFG YwhD family AW166_27390 ENOG4108Z4T Peptidase M50 AW166_27395 ENOG41069HH 4-oxalocrotonate tautomerase AW166_27400 ENOG4105DCI Phosphohydrolase AW166_27405 ENOG4108MES Periplasmic binding protein AW166_27410 ENOG4105E0A ABC, transporter AW166_27415 ENOG4105EHG Permease protein AW166_27420 ENOG4105DQ5 transport system permease protein AW166_27425 ENOG4105DQ5 transport system permease protein AW166_27435 ENOG4108VCI transcription factor, rsfa family AW166_27450 ENOG4108IJ2 phosphate acetyltransferase AW166_27465 ENOG4108VKI Cell wall hydrolase AW166_27495 ENOG410667J hydrolase AW166_27500 ENOG4105VCH membrane AW166_27510 ENOG4108TU7 Inherit from COG: (ABC) transporter AW166_27515 ENOG4105CJ1 ABC, transporter AW166_27520 ENOG41090WU lipolytic protein G-D-S-L family AW166_27535 ENOG4105D6E homoserine dehydrogenase AW166_27560 ENOG4108Y4K DNA-binding transcriptional activator AW166_27570 ENOG4105WH1 Two component transcriptional regulator luxr family AW166_27580 ENOG4105DWF phosphomethylpyrimidine kinase AW166_27585 ENOG4105BZU Histidine kinase AW166_27590 ENOG4105VCD cytoplasmic protein AW166_27595 ENOG4105D22 carbon starvation protein AW166_27600 ENOG4105DY9 regulatoR AW166_27605 ENOG41079KZ Major Facilitator Superfamily AW166_27625 ENOG4105EN6 Membrane AW166_27630 ENOG4106YBV Methyl-accepting chemotaxis AW166_27640 ENOG4108S4H thioesterase Superfamily protein AW166_27650 ENOG4105JEU Glycosyl transferase, family 2 AW166_27655 ENOG4105C5H ABC transporter AW166_27680 ENOG4105CKK Glycosyl transferase, family 2 AW166_27685 ENOG41067SE Tetr family transcriptional regulator AW166_27695 ENOG4105E0X reductase AW166_27700 ENOG4106F5Q Membrane AW166_27715 ENOG4105DY9 regulatoR AW166_27720 ENOG4108HRK Histidine kinase AW166_27725 ENOG4107RGD Major Facilitator superfamily AW166_27745 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW166_27755 ENOG4105IW1 AmiS UreI transporter AW166_27765 ENOG4105CMR udp-glucose 4-epimerase AW166_27770 ENOG4108UT2 hemolysin iii AW166_27780 ENOG4105C1J atp-dependent rna helicase AW166_27795 ENOG4105DPN Oligoendopeptidase f AW166_27815 ENOG4105C0H protease AW166_27820 ENOG4105Q2H domain protein AW166_27835 ENOG4105BZU Histidine kinase AW166_27840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW166_27870 ENOG4105CDU Replicative dna helicase AW166_27880 ENOG4105BZR domain protein AW166_27885 ENOG4108XMW Membrane AW166_27895 ENOG4108UUM single-stranded DNA-binding protein AW166_27905 ENOG4105C3G gtp-binding protein AW166_27910 ENOG4105VDK protein, conserved in bacteria AW166_27915 ENOG4105D8X mechanosensitive ion channel AW166_27920 ENOG4108ZDA Sporulation protein YyaC AW166_27925 ENOG4105FA0 parb-like partition protein AW166_27930 ENOG4107QJE Chromosome Partitioning Protein AW166_27950 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AW166_27960 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AW166_28015 ENOG4105EKQ RNA-directed DNA polymerase AW166_28095 ENOG4105EKQ RNA-directed DNA polymerase AW166_28215 ENOG4105CNU cell division protein FtsK AW166_28440 ENOG4105DHF Membrane AW166_28465 ENOG4106AKK s-layer domain-containing protein AW166_28470 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AW166_28495 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AW166_28500 ENOG4105C6Y Udp-glucose 6-dehydrogenase AW166_28515 ENOG4105DQ6 Transposase AW166_28555 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AW166_28670 ENOG4105KRN Transcriptional regulator, abrb family AW166_28680 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW166_28710 ENOG4108IBT Inherit from COG: transposase AW166_28720 ENOG4105DQ6 Transposase AW166_28740 ENOG4108MEK Metal-binding protein YodA AW166_28750 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AW166_28780 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AW166_28860 ENOG4105K4H Nlp p60 protein AW166_29005 ENOG4107QJE Chromosome Partitioning Protein AW166_29025 ENOG4105DQ6 Transposase AW166_29050 ENOG4105EWC Purine nucleoside phosphorylase AW166_29125 ENOG4105C3F Signal peptidase i AW166_29155 ENOG4105N14 lysine exporter protein LysE YggA AW166_29190 ENOG4108J59 Extracellular solute-binding protein, family 5 AW166_29205 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AW166_29265 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AW166_29270 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)