locus-tag	class	description
KM399_00010	COG0592	DNA-directed DNA polymerase activity
KM399_00015	COG2501	S4 domain
KM399_00025	COG0187	DNA topoisomerase II activity
KM399_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM399_00065	COG0516	GMP reductase activity
KM399_00065	COG0517	IMP dehydrogenase activity
KM399_00070	COG1686	Belongs to the peptidase S11 family
KM399_00100	COG1428	Deoxynucleoside kinase
KM399_00105	COG1428	Deoxynucleoside kinase
KM399_00110	COG1335	isochorismatase
KM399_00115	COG0590	tRNA wobble adenosine to inosine editing
KM399_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KM399_00180	COG1982	Orn Lys Arg decarboxylase major
KM399_00190	COG0470	DNA polymerase III
KM399_00195	COG1774	PSP1 C-terminal conserved region
KM399_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KM399_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KM399_00220	COG2002	toxin-antitoxin pair type II binding
KM399_00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM399_00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM399_00230	COG0084	hydrolase, TatD family'
KM399_00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM399_00250	COG4466	Protein conserved in bacteria
KM399_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KM399_00270	COG0251	oxidation-reduction process
KM399_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KM399_00305	COG2002	toxin-antitoxin pair type II binding
KM399_00310	COG2244	polysaccharide biosynthetic process
KM399_00315	COG3956	TIGRFAM MazG family protein
KM399_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KM399_00340	COG1098	S1 RNA binding domain
KM399_00355	COG2208	phosphoserine phosphatase activity
KM399_00360	COG0037	tRNA processing
KM399_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KM399_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM399_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM399_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KM399_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
KM399_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM399_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KM399_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KM399_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KM399_00420	COG1396	sequence-specific DNA binding
KM399_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM399_00455	COG3880	PFAM UvrB UvrC protein
KM399_00465	COG0542	response to heat
KM399_00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KM399_00480	COG4956	integral membrane protein (PIN domain superfamily)
KM399_00500	COG1045	serine acetyltransferase
KM399_00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM399_00520	COG3688	RNA-binding protein containing a PIN domain
KM399_00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM399_00540	COG0250	Participates in transcription elongation, termination and antitermination
KM399_00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KM399_00565	COG2813	Specifically methylates the guanine in position
KM399_00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KM399_00580	COG1358	cellular component organization or biogenesis
KM399_00650	COG0255	Belongs to the universal ribosomal protein uL29 family
KM399_00710	COG0201	protein transport
KM399_00720	COG0024	Methionine aminopeptidase
KM399_00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KM399_00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM399_00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM399_00795	COG0489	protein tyrosine kinase activity
KM399_00805	COG2194	sulfuric ester hydrolase activity
KM399_00810	COG0726	polysaccharide deacetylase
KM399_00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KM399_00895	COG4856	YbbR-like protein
KM399_00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KM399_00915	COG0596	Alpha beta hydrolase
KM399_00935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KM399_00940	COG0823	Involved in the tonB-independent uptake of proteins
KM399_00940	COG4946	Tricorn protease homolog
KM399_00940	COG1506	peptidase
KM399_00975	COG2011	ABC-type metal ion transport system permease component
KM399_00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM399_00985	COG1464	Belongs to the NlpA lipoprotein family
KM399_00990	COG0604	alcohol dehydrogenase
KM399_01000	COG0277	FAD linked oxidase domain protein
KM399_01005	COG2271	Major facilitator Superfamily
KM399_01015	COG2814	Major facilitator Superfamily
KM399_01030	COG0601	transmembrane transport
KM399_01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM399_01040	COG0444	Belongs to the ABC transporter superfamily
KM399_01045	COG4608	Belongs to the ABC transporter superfamily
KM399_01050	COG4166	transmembrane transport
KM399_01060	COG2207	Transcriptional regulator
KM399_01075	COG4166	transmembrane transport
KM399_01080	COG4166	transmembrane transport
KM399_01085	COG0656	L-ascorbic acid biosynthetic process
KM399_01090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM399_01105	COG4149	molybdate abc transporter
KM399_01115	COG1910	domain protein
KM399_01125	COG0583	DNA-binding transcription factor activity
KM399_01130	COG0697	spore germination
KM399_01145	COG0204	Acyl-transferase
KM399_01155	COG1609	Transcriptional regulator
KM399_01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM399_01175	COG0084	hydrolase, TatD family'
KM399_01180	COG5298	Protein conserved in bacteria
KM399_01205	COG0488	(ABC) transporter
KM399_01220	COG0747	negative chemotaxis
KM399_01225	COG0601	transmembrane transport
KM399_01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM399_01235	COG0444	Belongs to the ABC transporter superfamily
KM399_01240	COG4608	Belongs to the ABC transporter superfamily
KM399_01275	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KM399_01280	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM399_01290	COG2814	Major facilitator Superfamily
KM399_01300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KM399_01310	COG4294	response to UV
KM399_01315	COG0705	Rhomboid family
KM399_01315	COG0457	Tetratricopeptide repeat
KM399_01325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KM399_01330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM399_01335	COG0864	Transcriptional regulator
KM399_01340	COG2337	Toxic component of a toxin-antitoxin (TA) module
KM399_01345	COG2183	response to ionizing radiation
KM399_01440	COG0802	atpase or kinase
KM399_01445	COG1214	PFAM Peptidase M22, glycoprotease
KM399_01450	COG0456	acetyltransferase
KM399_01460	COG0488	(ABC) transporter
KM399_01475	COG1266	CAAX protease self-immunity
KM399_01495	COG2252	PERMEase
KM399_01505	COG5002	protein histidine kinase activity
KM399_01535	COG2226	methyltransferase
KM399_01575	COG1968	undecaprenyl-diphosphatase activity
KM399_01590	COG2205	protein histidine kinase activity
KM399_01595	COG0745	RESPONSE REGULATOR receiver
KM399_01615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KM399_01620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KM399_01625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KM399_01635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KM399_01650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KM399_01660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KM399_01670	COG0151	Belongs to the GarS family
KM399_01695	COG0210	DNA helicase
KM399_01705	COG4851	CamS sex pheromone cAM373 precursor
KM399_01725	COG1335	isochorismatase
KM399_01730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM399_01735	COG2011	ABC-type metal ion transport system permease component
KM399_01740	COG1464	Belongs to the NlpA lipoprotein family
KM399_01760	COG1846	Transcriptional regulator
KM399_01785	COG1597	lipid kinase activity
KM399_01790	COG0546	phosphoglycolate phosphatase activity
KM399_01795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM399_01805	COG1012	belongs to the aldehyde dehydrogenase family
KM399_01810	COG2076	Multidrug Resistance protein
KM399_01815	COG2309	aminopeptidase activity
KM399_01830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM399_01835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM399_01840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM399_01850	COG4807	Protein conserved in bacteria
KM399_01875	COG1757	Na H antiporter
KM399_01880	COG1473	amidohydrolase
KM399_01895	COG0450	alkyl hydroperoxide reductase
KM399_01915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM399_01920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM399_01925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM399_01940	COG0166	Belongs to the GPI family
KM399_01975	COG5002	protein histidine kinase activity
KM399_01995	COG3541	Predicted nucleotidyltransferase
KM399_02000	COG2814	Major facilitator Superfamily
KM399_02005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM399_02005	COG0723	plastoquinol--plastocyanin reductase activity
KM399_02015	COG0765	amino acid transport
KM399_02020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM399_02030	COG0840	transmembrane signaling receptor activity
KM399_02035	COG0840	transmembrane signaling receptor activity
KM399_02040	COG0366	Alpha amylase catalytic
KM399_02045	COG1263	PTS System
KM399_02045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM399_02045	COG2190	(PTS) system
KM399_02075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KM399_02090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM399_02100	COG1116	anion transmembrane transporter activity
KM399_02105	COG0488	(ABC) transporter
KM399_02150	COG2270	Major facilitator Superfamily
KM399_02165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM399_02180	COG2310	stress, protein
KM399_02185	COG2310	stress, protein
KM399_02190	COG2310	stress, protein
KM399_02195	COG0861	Integral membrane protein TerC family
KM399_02205	COG3853	Toxic anion resistance protein (TelA)
KM399_02220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KM399_02230	COG1295	ribonuclease BN
KM399_02235	COG2217	Heavy metal translocating P-type atpase
KM399_02240	COG0697	spore germination
KM399_02260	COG0586	Pfam SNARE associated Golgi protein
KM399_02275	COG3871	stress protein (general stress protein 26)
KM399_02280	COG0387	Pfam Sodium calcium exchanger
KM399_02290	COG0535	radical SAM domain protein
KM399_02315	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM399_02320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM399_02325	COG0582	viral genome integration into host DNA
KM399_02335	COG1396	sequence-specific DNA binding
KM399_02350	COG1396	sequence-specific DNA binding
KM399_02385	COG1484	DNA-dependent DNA replication
KM399_02615	COG0101	tRNA pseudouridine synthase activity
KM399_02625	COG3829	transcription factor binding
KM399_02635	COG0833	amino acid
KM399_02640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM399_02670	COG1263	PTS System
KM399_02670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM399_02675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM399_02690	COG0463	Glycosyl transferase, family 2
KM399_02705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KM399_02705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM399_02725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KM399_02745	COG1228	amidohydrolase
KM399_02750	COG1090	epimerase
KM399_02780	COG1988	membrane-bound metal-dependent
KM399_02785	COG1194	a g-specific adenine glycosylase
KM399_02810	COG1132	(ABC) transporter
KM399_02815	COG4129	membrane
KM399_02820	COG0069	glutamate synthase activity
KM399_02820	COG0070	glutamate synthase
KM399_02820	COG0067	glutamate synthase
KM399_02830	COG4555	ABC transporter
KM399_02850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KM399_02855	COG0735	belongs to the Fur family
KM399_02970	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KM399_02975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KM399_02985	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KM399_02995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KM399_03005	COG2766	serine protein kinase
KM399_03025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM399_03035	COG1585	Membrane protein implicated in regulation of membrane protease activity
KM399_03040	COG2268	Band 7 protein
KM399_03050	COG3290	protein histidine kinase activity
KM399_03055	COG4565	transcriptional regulatory protein
KM399_03060	COG2851	Citrate transporter
KM399_03080	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM399_03085	COG3842	ATPase activity
KM399_03090	COG1175	transmembrane transport
KM399_03095	COG0395	ABC-type sugar transport system, permease component
KM399_03105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KM399_03110	COG0745	RESPONSE REGULATOR receiver
KM399_03115	COG5002	protein histidine kinase activity
KM399_03125	COG4990	cell redox homeostasis
KM399_03135	COG3290	protein histidine kinase activity
KM399_03140	COG4565	transcriptional regulatory protein
KM399_03145	COG3493	citrate carrier protein
KM399_03150	COG0281	malic enzyme
KM399_03165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM399_03175	COG5002	protein histidine kinase activity
KM399_03180	COG0745	RESPONSE REGULATOR receiver
KM399_03185	COG0456	acetyltransferase
KM399_03185	COG0454	-acetyltransferase
KM399_03190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM399_03195	COG3383	formate dehydrogenase (NAD+) activity
KM399_03200	COG2427	Protein of unknown function (DUF1641)
KM399_03215	COG0531	amino acid
KM399_03220	COG0640	Transcriptional regulator
KM399_03225	COG2217	Heavy metal translocating P-type atpase
KM399_03230	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KM399_03245	COG3227	Zinc metalloprotease (Elastase)
KM399_03265	COG2720	vancomycin resistance protein
KM399_03270	COG1316	TRANSCRIPTIONal
KM399_03275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM399_03280	COG0346	lactoylglutathione lyase activity
KM399_03285	COG1253	flavin adenine dinucleotide binding
KM399_03290	COG1027	Aspartate ammonia-lyase
KM399_03295	COG1620	l-lactate permease
KM399_03310	COG3104	oligopeptide transport
KM399_03315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM399_03320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM399_03325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM399_03335	COG2226	methyltransferase
KM399_03340	COG0156	8-amino-7-oxononanoate synthase activity
KM399_03345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM399_03355	COG4548	von Willebrand factor, type A
KM399_03360	COG0714	Associated with various cellular activities
KM399_03365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM399_03385	COG0531	amino acid
KM399_03390	COG2188	Transcriptional regulator
KM399_03395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM399_03395	COG1263	PTS System
KM399_03400	COG0366	Alpha amylase catalytic
KM399_03415	COG0697	spore germination
KM399_03425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM399_03430	COG1115	amino acid carrier protein
KM399_03435	COG1126	abc transporter atp-binding protein
KM399_03440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM399_03445	COG0765	amino acid transport
KM399_03450	COG0765	amino acid transport
KM399_03455	COG0833	amino acid
KM399_03480	COG2378	regulation of single-species biofilm formation
KM399_03485	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KM399_03490	COG5002	protein histidine kinase activity
KM399_03505	COG0659	secondary active sulfate transmembrane transporter activity
KM399_03520	COG0747	negative chemotaxis
KM399_03530	COG0601	transmembrane transport
KM399_03535	COG4608	Belongs to the ABC transporter superfamily
KM399_03545	COG2271	Major facilitator Superfamily
KM399_03550	COG1846	Transcriptional regulator
KM399_03560	COG1609	Transcriptional regulator
KM399_03565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM399_03580	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM399_03585	COG1879	ABC-type sugar transport system periplasmic component
KM399_03610	COG1063	alcohol dehydrogenase
KM399_03625	COG3568	Endonuclease Exonuclease Phosphatase
KM399_03650	COG1968	undecaprenyl-diphosphatase activity
KM399_03655	COG0840	transmembrane signaling receptor activity
KM399_03660	COG1388	LysM domain
KM399_03660	COG3584	3D domain protein
KM399_03665	COG1476	TRANSCRIPTIONal
KM399_03680	COG3104	oligopeptide transport
KM399_03685	COG1114	Component of the transport system for branched-chain amino acids
KM399_03700	COG1113	amino acid transport
KM399_03705	COG2252	PERMEase
KM399_03730	COG0475	glutathione-regulated potassium exporter activity
KM399_03730	COG0569	domain protein
KM399_03745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KM399_03750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KM399_03755	COG0833	amino acid
KM399_03760	COG4990	cell redox homeostasis
KM399_03775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM399_03780	COG0697	spore germination
KM399_03785	COG0531	amino acid
KM399_03795	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM399_03800	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM399_03805	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM399_03805	COG1918	ferrous iron import across plasma membrane
KM399_03810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM399_03815	COG0573	inorganic phosphate transmembrane transporter activity
KM399_03820	COG0581	inorganic phosphate transmembrane transporter activity
KM399_03830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM399_03950	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KM399_03970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM399_03975	COG1116	anion transmembrane transporter activity
KM399_03980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM399_03985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM399_03990	COG0352	thiamine-phosphate diphosphorylase activity
KM399_03995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM399_04000	COG2104	thiamine diphosphate biosynthetic process
KM399_04010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM399_04015	COG0351	phosphomethylpyrimidine kinase
KM399_04055	COG2205	protein histidine kinase activity
KM399_04060	COG2814	Major facilitator Superfamily
KM399_04065	COG1846	Transcriptional regulator
KM399_04080	COG2252	PERMEase
KM399_04085	COG1028	Short-chain dehydrogenase reductase Sdr
KM399_04100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM399_04105	COG1621	beta-fructofuranosidase activity
KM399_04110	COG1263	PTS System
KM399_04110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM399_04115	COG1609	Transcriptional regulator
KM399_04125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM399_04130	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KM399_04165	COG0778	Nitroreductase
KM399_04170	COG2719	SpoVR family
KM399_04195	COG0446	pyridine nucleotide-disulphide oxidoreductase
KM399_04200	COG1937	Protein conserved in bacteria
KM399_04205	COG0425	Belongs to the sulfur carrier protein TusA family
KM399_04205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM399_04210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM399_04210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM399_04215	COG0425	Belongs to the sulfur carrier protein TusA family
KM399_04220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM399_04230	COG2210	Belongs to the sulfur carrier protein TusA family
KM399_04235	COG0730	response to heat
KM399_04245	COG1316	TRANSCRIPTIONal
KM399_04250	COG0604	alcohol dehydrogenase
KM399_04255	COG1283	sodium-dependent phosphate transmembrane transporter activity
KM399_04270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM399_04270	COG3711	transcriptional antiterminator
KM399_04275	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM399_04280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM399_04300	COG1388	LysM domain
KM399_04300	COG3584	3D domain protein
KM399_04305	COG0577	efflux transmembrane transporter activity
KM399_04310	COG1136	(ABC) transporter
KM399_04320	COG5522	Integral membrane protein (intg_mem_TP0381)
KM399_04335	COG1114	Component of the transport system for branched-chain amino acids
KM399_04340	COG3546	catalase activity
KM399_04375	COG0586	Pfam SNARE associated Golgi protein
KM399_04410	COG0531	amino acid
KM399_04415	COG0475	glutathione-regulated potassium exporter activity
KM399_04425	COG1737	Transcriptional regulator
KM399_04435	COG1263	PTS System
KM399_04435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM399_04445	COG2259	Doxx family
KM399_04460	COG0697	spore germination
KM399_04465	COG1522	sequence-specific DNA binding
KM399_04480	COG2076	Multidrug Resistance protein
KM399_04485	COG1309	transcriptional regulator
KM399_04490	COG2814	Major facilitator Superfamily
KM399_04495	COG1733	regulation of RNA biosynthetic process
KM399_04505	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM399_04510	COG4533	DNA binding
KM399_04515	COG2211	Major facilitator Superfamily
KM399_04525	COG0693	protein deglycase activity
KM399_04530	COG0753	catalase activity
KM399_04530	COG0693	protein deglycase activity
KM399_04540	COG0531	amino acid
KM399_04545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KM399_04555	COG1012	belongs to the aldehyde dehydrogenase family
KM399_04560	COG1132	(ABC) transporter
KM399_04570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM399_04575	COG0765	amino acid transport
KM399_04580	COG1126	abc transporter atp-binding protein
KM399_04595	COG0189	ligase activity
KM399_04625	COG0028	Belongs to the TPP enzyme family
KM399_04630	COG3527	Alpha-acetolactate decarboxylase
KM399_04645	COG0561	phosphatase activity
KM399_04660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM399_04675	COG0659	secondary active sulfate transmembrane transporter activity
KM399_04695	COG0653	protein targeting
KM399_04700	COG2244	polysaccharide biosynthetic process
KM399_04710	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM399_04715	COG4196	transglutaminase domain protein
KM399_04730	COG1696	Membrane protein involved in D-alanine export
KM399_04745	COG1024	Enoyl-CoA hydratase
KM399_04765	COG1363	Peptidase, m42
KM399_04785	COG3938	Belongs to the proline racemase family
KM399_04825	COG0601	transmembrane transport
KM399_04830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM399_04840	COG4608	Belongs to the ABC transporter superfamily
KM399_04845	COG0322	excinuclease ABC activity
KM399_04875	COG0477	Major facilitator Superfamily
KM399_04880	COG3290	protein histidine kinase activity
KM399_04885	COG4565	transcriptional regulatory protein
KM399_04890	COG3181	Tripartite tricarboxylate transporter family receptor
KM399_04920	COG0789	Transcriptional regulator
KM399_04920	COG4978	Transcriptional regulator
KM399_04935	COG0305	Participates in initiation and elongation during chromosome replication
KM399_04975	COG0477	Major facilitator Superfamily
KM399_05020	COG3320	Male sterility
KM399_05020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM399_05025	COG1309	transcriptional regulator
KM399_05045	COG1183	phosphatidylcholine synthase activity
KM399_05065	COG2376	Dihydroxyacetone kinase
KM399_05075	COG2376	Dihydroxyacetone kinase
KM399_05080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM399_05085	COG1959	2 iron, 2 sulfur cluster binding
KM399_05115	COG2770	Histidine kinase
KM399_05115	COG3437	response regulator, receiver
KM399_05165	COG3237	CsbD-like
KM399_05190	COG1191	sigma factor activity
KM399_05200	COG2208	phosphoserine phosphatase activity
KM399_05205	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM399_05210	COG2205	protein histidine kinase activity
KM399_05210	COG0784	Response regulator, receiver
KM399_05210	COG2198	Histidine kinase
KM399_05210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM399_05265	COG0420	3'-5' exonuclease activity
KM399_05270	COG4717	serine-type aminopeptidase activity
KM399_05290	COG1309	transcriptional regulator
KM399_05295	COG2814	Major facilitator Superfamily
KM399_05300	COG0346	lactoylglutathione lyase activity
KM399_05310	COG0346	lactoylglutathione lyase activity
KM399_05315	COG0457	Tetratricopeptide repeat
KM399_05320	COG2267	carboxylic ester hydrolase activity
KM399_05340	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM399_05345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KM399_05355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KM399_05395	COG0477	Major facilitator Superfamily
KM399_05400	COG0477	Major facilitator Superfamily
KM399_05410	COG3973	AAA domain
KM399_05415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM399_05435	COG4980	gas vesicle protein
KM399_05440	COG0537	adenosine 5'-monophosphoramidase activity
KM399_05445	COG1131	(ABC) transporter
KM399_05450	COG4473	ABC transporter
KM399_05465	COG1309	transcriptional regulator
KM399_05475	COG3402	PFAM membrane-flanked domain
KM399_05525	COG3402	PFAM membrane-flanked domain
KM399_05530	COG3428	Bacterial PH domain
KM399_05535	COG2329	Antibiotic biosynthesis monooxygenase
KM399_05540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM399_05545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KM399_05550	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM399_05555	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM399_05590	COG1309	transcriptional regulator
KM399_05595	COG1511	domain protein
KM399_05620	COG1609	Transcriptional regulator
KM399_05630	COG1234	tRNA 3'-trailer cleavage
KM399_05635	COG0095	Lipoate-protein ligase
KM399_05645	COG0318	PFAM AMP-dependent synthetase and ligase
KM399_05675	COG3209	COG3209 Rhs family protein
KM399_05720	COG1078	dGTPase activity
KM399_05730	COG1595	DNA-templated transcription, initiation
KM399_05735	COG2207	Transcriptional regulator
KM399_05735	COG3708	Transcriptional regulator
KM399_05750	COG2205	protein histidine kinase activity
KM399_05755	COG0745	RESPONSE REGULATOR receiver
KM399_05780	COG0501	Belongs to the peptidase M48B family
KM399_05785	COG0840	transmembrane signaling receptor activity
KM399_05790	COG0697	spore germination
KM399_05810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KM399_05815	COG2224	Isocitrate lyase
KM399_05840	COG4903	ComK protein
KM399_05845	COG0398	Pfam SNARE associated Golgi protein
KM399_05855	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KM399_05860	COG1074	ATP-dependent DNA helicase activity
KM399_05905	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM399_05930	COG0367	asparagine synthase
KM399_05935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM399_05940	COG0753	catalase activity
KM399_05945	COG0004	ammonium transporteR
KM399_05965	COG2996	Protein conserved in bacteria
KM399_05975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM399_05985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM399_06000	COG0561	phosphatase activity
KM399_06010	COG0542	response to heat
KM399_06020	COG2267	carboxylic ester hydrolase activity
KM399_06035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM399_06040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KM399_06045	COG5504	Zn-dependent protease
KM399_06055	COG0180	Tryptophanyl-tRNA synthetase
KM399_06065	COG4166	transmembrane transport
KM399_06070	COG0601	transmembrane transport
KM399_06075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM399_06080	COG0444	Belongs to the ABC transporter superfamily
KM399_06085	COG4608	Belongs to the ABC transporter superfamily
KM399_06090	COG0534	Mate efflux family protein
KM399_06095	COG4166	transmembrane transport
KM399_06110	COG0861	Integral membrane protein TerC family
KM399_06115	COG4862	establishment of competence for transformation
KM399_06120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM399_06130	COG1164	Oligoendopeptidase f
KM399_06140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM399_06145	COG2346	COG2346, Truncated hemoglobins
KM399_06150	COG4116	CYTH
KM399_06160	COG2357	RelA SpoT domain protein
KM399_06170	COG0564	pseudouridine synthase activity
KM399_06190	COG1216	Glycosyl transferase, family 2
KM399_06190	COG0463	Glycosyl transferase, family 2
KM399_06210	COG0463	Glycosyl transferase, family 2
KM399_06210	COG0457	Tetratricopeptide repeat
KM399_06230	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KM399_06245	COG1091	dTDP-4-dehydrorhamnose reductase activity
KM399_06290	COG2153	protein acetylation
KM399_06300	COG2382	esterase
KM399_06315	COG5492	domain, Protein
KM399_06320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM399_06330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KM399_06330	COG0512	Glutamine amidotransferase of anthranilate synthase
KM399_06365	COG1620	l-lactate permease
KM399_06370	COG5634	Uncharacterized conserved protein (DUF2278)
KM399_06425	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM399_06435	COG1476	TRANSCRIPTIONal
KM399_06495	COG2226	methyltransferase
KM399_06505	COG1686	Belongs to the peptidase S11 family
KM399_06510	COG0681	Belongs to the peptidase S26 family
KM399_06545	COG1012	belongs to the aldehyde dehydrogenase family
KM399_06550	COG3842	ATPase activity
KM399_06555	COG1176	ABC-type spermidine putrescine transport system, permease component I
KM399_06560	COG1177	transmembrane transport
KM399_06565	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KM399_06575	COG2409	Drug exporters of the RND superfamily
KM399_06585	COG0564	pseudouridine synthase activity
KM399_06595	COG2340	Cysteine-rich secretory protein family
KM399_06600	COG0247	lactate metabolic process
KM399_06605	COG0277	FAD linked oxidase domain protein
KM399_06610	COG3835	regulator
KM399_06620	COG0745	RESPONSE REGULATOR receiver
KM399_06625	COG5002	protein histidine kinase activity
KM399_06630	COG2186	Transcriptional regulator
KM399_06650	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KM399_06665	COG2116	formate transmembrane transporter activity
KM399_06670	COG0861	Integral membrane protein TerC family
KM399_06675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM399_06685	COG2030	dehydratase
KM399_06705	COG1028	Short-chain dehydrogenase reductase Sdr
KM399_06710	COG3243	poly(R)-hydroxyalkanoic acid synthase
KM399_06715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM399_06720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM399_06735	COG1840	ABC-type Fe3 transport system, periplasmic component
KM399_06765	COG1349	DNA-binding transcription factor activity
KM399_06785	COG2861	carbohydrate metabolic process
KM399_06795	COG3852	Histidine kinase
KM399_06800	COG1846	Transcriptional regulator
KM399_06810	COG2318	DinB family
KM399_06815	COG5002	protein histidine kinase activity
KM399_06825	COG0720	synthase
KM399_06840	COG4873	Protein conserved in bacteria
KM399_06870	COG1780	Probably involved in ribonucleotide reductase function
KM399_06890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KM399_06895	COG1725	Transcriptional regulator
KM399_06900	COG1131	(ABC) transporter
KM399_06910	COG1131	(ABC) transporter
KM399_06915	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM399_06930	COG1522	sequence-specific DNA binding
KM399_06940	COG1335	isochorismatase
KM399_06950	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM399_06955	COG2070	2-Nitropropane dioxygenase
KM399_06960	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM399_06970	COG1696	Membrane protein involved in D-alanine export
KM399_06995	COG0716	FMN binding
KM399_07010	COG3173	Aminoglycoside phosphotransferase
KM399_07030	COG0534	Mate efflux family protein
KM399_07035	COG1968	undecaprenyl-diphosphatase activity
KM399_07050	COG1846	Transcriptional regulator
KM399_07060	COG1301	dicarboxylic acid transport
KM399_07065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM399_07070	COG4709	membrane
KM399_07075	COG3874	Sporulation protein YtfJ
KM399_07100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM399_07105	COG0028	Belongs to the TPP enzyme family
KM399_07110	COG0440	acetolactate synthase activity
KM399_07115	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM399_07125	COG0473	3-isopropylmalate dehydrogenase activity
KM399_07150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KM399_07185	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM399_07200	COG1183	phosphatidylcholine synthase activity
KM399_07205	COG1368	sulfuric ester hydrolase activity
KM399_07215	COG0019	diaminopimelate decarboxylase activity
KM399_07235	COG0529	Catalyzes the synthesis of activated sulfate
KM399_07240	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM399_07260	COG1648	precorrin-2 dehydrogenase activity
KM399_07265	COG0733	neurotransmitter:sodium symporter activity
KM399_07285	COG1757	Na H antiporter
KM399_07300	COG4758	membrane
KM399_07305	COG4585	Histidine kinase
KM399_07310	COG2197	response regulator
KM399_07320	COG1114	Component of the transport system for branched-chain amino acids
KM399_07330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KM399_07355	COG1017	nitric oxide dioxygenase activity
KM399_07355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KM399_07370	COG0730	response to heat
KM399_07375	COG0306	phosphate transporter
KM399_07380	COG1392	Phosphate transport regulator
KM399_07385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM399_07400	COG3852	Histidine kinase
KM399_07405	COG1801	Protein of unknown function DUF72
KM399_07415	COG0582	viral genome integration into host DNA
KM399_07420	COG5002	protein histidine kinase activity
KM399_07440	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KM399_07440	COG0392	lysyltransferase activity
KM399_07455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM399_07460	COG1686	Belongs to the peptidase S11 family
KM399_07465	COG2715	membrane protein required for spore maturation
KM399_07470	COG0700	Nucleoside recognition
KM399_07475	COG1187	pseudouridine synthase activity
KM399_07485	COG1333	cytochrome c biogenesis protein
KM399_07490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM399_07495	COG0745	RESPONSE REGULATOR receiver
KM399_07500	COG5002	protein histidine kinase activity
KM399_07505	COG2096	Adenosyltransferase
KM399_07520	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KM399_07525	COG1141	Ferredoxin
KM399_07530	COG4955	Helix-turn-helix domain
KM399_07535	COG0514	ATP-dependent DNA helicase (RecQ)
KM399_07540	COG1266	CAAX protease self-immunity
KM399_07560	COG4862	establishment of competence for transformation
KM399_07565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KM399_07585	COG0492	ferredoxin-NADP+ reductase activity
KM399_07660	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM399_07675	COG0142	geranyltranstransferase activity
KM399_07685	COG0142	geranyltranstransferase activity
KM399_07705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM399_07710	COG0457	Tetratricopeptide repeat
KM399_07730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KM399_07740	COG4347	Protein of unknown function (DUF1405)
KM399_07755	COG2738	Putative neutral zinc metallopeptidase
KM399_07765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM399_07770	COG1694	Mazg nucleotide pyrophosphohydrolase
KM399_07785	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM399_07790	COG0438	transferase activity, transferring glycosyl groups
KM399_07825	COG1199	ATP-dependent helicase activity
KM399_07825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KM399_07845	COG3935	DnaD domain protein
KM399_07850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KM399_07860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM399_07860	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM399_07920	COG0116	Belongs to the methyltransferase superfamily
KM399_07930	COG1199	ATP-dependent helicase activity
KM399_07935	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KM399_07945	COG3173	Aminoglycoside phosphotransferase
KM399_07950	COG0024	Methionine aminopeptidase
KM399_07960	COG2233	PERMEase
KM399_07965	COG2311	Membrane
KM399_07970	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM399_07980	COG0456	acetyltransferase
KM399_08030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM399_08055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KM399_08070	COG1215	transferase activity, transferring glycosyl groups
KM399_08075	COG0438	transferase activity, transferring glycosyl groups
KM399_08090	COG0454	-acetyltransferase
KM399_08110	COG0328	RNA-DNA hybrid ribonuclease activity
KM399_08150	COG1280	lysine exporter protein (LysE YggA)
KM399_08165	COG3162	membrane
KM399_08170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM399_08175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM399_08185	COG0475	glutathione-regulated potassium exporter activity
KM399_08190	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM399_08195	COG0789	Transcriptional regulator
KM399_08195	COG4978	Transcriptional regulator
KM399_08205	COG2323	membrane
KM399_08210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KM399_08265	COG1923	regulation of RNA biosynthetic process
KM399_08275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM399_08280	COG1360	Flagellar Motor Protein
KM399_08285	COG2201	protein-glutamate methylesterase activity
KM399_08290	COG2198	Histidine kinase
KM399_08290	COG0643	Histidine kinase
KM399_08295	COG2198	Histidine kinase
KM399_08295	COG0643	Histidine kinase
KM399_08300	COG1776	CheC inhibitor of MCP methylation
KM399_08300	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM399_08315	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM399_08335	COG1256	bacterial-type flagellum assembly
KM399_08360	COG1815	bacterial-type flagellum-dependent cell motility
KM399_08365	COG1558	bacterial-type flagellum-dependent cell motility
KM399_08380	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM399_08390	COG1157	protein secretion by the type III secretion system
KM399_08430	COG0835	chemotaxis
KM399_08430	COG0784	Response regulator, receiver
KM399_08440	COG0463	Glycosyl transferase, family 2
KM399_08475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KM399_08480	COG0741	lytic transglycosylase activity
KM399_08495	COG1776	CheC inhibitor of MCP methylation
KM399_08495	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM399_08505	COG1338	Plays a role in the flagellum-specific transport system
KM399_08510	COG1987	bacterial-type flagellum assembly
KM399_08520	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM399_08525	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM399_08530	COG1419	protein localization to endoplasmic reticulum
KM399_08535	COG4786	Flagellar basal body rod
KM399_08540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM399_08565	COG1309	transcriptional regulator
KM399_08585	COG2329	Antibiotic biosynthesis monooxygenase
KM399_08610	COG0583	DNA-binding transcription factor activity
KM399_08615	COG3842	ATPase activity
KM399_08620	COG0725	ABC transporter, periplasmic molybdate-binding protein
KM399_08630	COG1234	tRNA 3'-trailer cleavage
KM399_08655	COG1686	Belongs to the peptidase S11 family
KM399_08665	COG0406	alpha-ribazole phosphatase activity
KM399_08695	COG0367	asparagine synthase
KM399_08725	COG1802	Transcriptional regulator
KM399_08730	COG0697	spore germination
KM399_08735	COG0523	cobalamin synthesis protein
KM399_08740	COG0701	Predicted permease
KM399_08750	COG1216	Glycosyl transferase, family 2
KM399_08750	COG0438	transferase activity, transferring glycosyl groups
KM399_08755	COG1757	Na H antiporter
KM399_08760	COG0114	fumarate hydratase activity
KM399_08785	COG3340	Belongs to the peptidase S51 family
KM399_08805	COG0785	Cytochrome C biogenesis protein
KM399_08835	COG2733	membrane
KM399_08870	COG1131	(ABC) transporter
KM399_08885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM399_08890	COG0528	UMP kinase activity
KM399_08900	COG1027	Aspartate ammonia-lyase
KM399_08905	COG0281	malic enzyme
KM399_08910	COG4191	Histidine kinase
KM399_08915	COG0784	Response regulator, receiver
KM399_08920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM399_08975	COG1051	belongs to the nudix hydrolase family
KM399_08980	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM399_08990	COG2814	Major facilitator Superfamily
KM399_09005	COG1966	Carbon starvation protein
KM399_09020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM399_09030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KM399_09040	COG2223	nitrite transmembrane transporter activity
KM399_09045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM399_09060	COG2244	polysaccharide biosynthetic process
KM399_09065	COG0733	neurotransmitter:sodium symporter activity
KM399_09075	COG5566	PFAM Mor transcription activator
KM399_09080	COG2323	membrane
KM399_09095	COG2084	Dehydrogenase
KM399_09110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM399_09120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM399_09125	COG0028	Belongs to the TPP enzyme family
KM399_09130	COG0440	acetolactate synthase activity
KM399_09135	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM399_09145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KM399_09170	COG2814	Major facilitator Superfamily
KM399_09175	COG3384	dioxygenase
KM399_09185	COG3279	Response regulator of the LytR AlgR family
KM399_09190	COG0427	acetyl-CoA hydrolase
KM399_09210	COG1073	alpha beta
KM399_09240	COG0535	radical SAM domain protein
KM399_09245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM399_09265	COG1914	H( )-stimulated, divalent metal cation uptake system
KM399_09280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM399_09310	COG2390	Transcriptional regulator
KM399_09320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM399_09325	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KM399_09340	COG4224	UPF0291 protein
KM399_09360	COG0006	proline dipeptidase activity
KM399_09365	COG2132	Multicopper oxidase
KM399_09380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM399_09395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM399_09410	COG1276	copper resistance
KM399_09410	COG2372	response to copper ion
KM399_09415	COG4549	nuclear export factor GLE1
KM399_09425	COG0697	spore germination
KM399_09430	COG0583	DNA-binding transcription factor activity
KM399_09435	COG1959	2 iron, 2 sulfur cluster binding
KM399_09440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM399_09445	COG0778	Nitroreductase
KM399_09455	COG0628	permease
KM399_09465	COG1231	oxidoreductase activity
KM399_09470	COG0523	cobalamin synthesis protein
KM399_09485	COG0318	PFAM AMP-dependent synthetase and ligase
KM399_09490	COG2030	dehydratase
KM399_09495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM399_09505	COG0411	ABC transporter
KM399_09525	COG0583	DNA-binding transcription factor activity
KM399_09535	COG1942	4-Oxalocrotonate Tautomerase
KM399_09545	COG1846	Transcriptional regulator
KM399_09555	COG1271	oxidase subunit
KM399_09560	COG1294	oxidase, subunit
KM399_09565	COG4988	ABC transporter
KM399_09570	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KM399_09590	COG1686	Belongs to the peptidase S11 family
KM399_09605	COG0791	NLP P60 protein
KM399_09605	COG1388	LysM domain
KM399_09620	COG0745	RESPONSE REGULATOR receiver
KM399_09625	COG5002	protein histidine kinase activity
KM399_09635	COG0300	oxidoreductase activity
KM399_09670	COG0460	homoserine dehydrogenase
KM399_09695	COG1316	TRANSCRIPTIONal
KM399_09705	COG0745	RESPONSE REGULATOR receiver
KM399_09710	COG5002	protein histidine kinase activity
KM399_09725	COG1285	pathogenesis
KM399_09730	COG1247	-acetyltransferase
KM399_09750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM399_09760	COG1082	Xylose isomerase domain protein TIM barrel
KM399_09775	COG1279	arginine transmembrane transporter activity
KM399_09785	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM399_09825	COG2002	toxin-antitoxin pair type II binding
KM399_09830	COG1404	Belongs to the peptidase S8 family
KM399_09835	COG0640	Transcriptional regulator
KM399_09840	COG0667	Aldo Keto reductase
KM399_09845	COG2814	Major facilitator Superfamily
KM399_09870	COG0840	transmembrane signaling receptor activity
KM399_09885	COG3949	Membrane
KM399_09890	COG0783	Belongs to the Dps family
KM399_09905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM399_09915	COG1231	oxidoreductase activity
KM399_09925	COG4989	oxidoreductase activity
KM399_09930	COG0523	cobalamin synthesis protein
KM399_09935	COG0456	acetyltransferase
KM399_09990	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM399_09990	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM399_10000	COG0702	epimerase
KM399_10010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM399_10020	COG4166	transmembrane transport
KM399_10035	COG0406	alpha-ribazole phosphatase activity
KM399_10045	COG5337	Spore coat protein CotH
KM399_10050	COG1051	belongs to the nudix hydrolase family
KM399_10055	COG0586	Pfam SNARE associated Golgi protein
KM399_10060	COG2244	polysaccharide biosynthetic process
KM399_10070	COG0701	Predicted permease
KM399_10075	COG3689	TIGRFAM TIGR03943 family protein
KM399_10080	COG1607	acyl-coa hydrolase
KM399_10090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM399_10105	COG0702	epimerase
KM399_10110	COG2839	Protein conserved in bacteria
KM399_10115	COG1253	flavin adenine dinucleotide binding
KM399_10130	COG1114	Component of the transport system for branched-chain amino acids
KM399_10135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM399_10155	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM399_10165	COG1876	peptidase activity
KM399_10175	COG0154	amidase activity
KM399_10180	COG2211	Major facilitator Superfamily
KM399_10200	COG0561	phosphatase activity
KM399_10210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM399_10215	COG4106	trans-aconitate 2-methyltransferase activity
KM399_10230	COG1819	glycosyl
KM399_10235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM399_10240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM399_10265	COG0456	acetyltransferase
KM399_10315	COG3874	Sporulation protein YtfJ
KM399_10340	COG2226	methyltransferase
KM399_10365	COG0346	lactoylglutathione lyase activity
KM399_10375	COG0604	alcohol dehydrogenase
KM399_10380	COG1595	DNA-templated transcription, initiation
KM399_10405	COG0386	Belongs to the glutathione peroxidase family
KM399_10410	COG1305	Transglutaminase-like
KM399_10415	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KM399_10420	COG0714	Associated with various cellular activities
KM399_10435	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KM399_10440	COG1140	nitrate reductase beta subunit
KM399_10445	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KM399_10450	COG2181	nitrate reductase activity
KM399_10470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM399_10475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KM399_10480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM399_10485	COG0303	'Molybdopterin
KM399_10490	COG0314	molybdopterin synthase activity
KM399_10500	COG2223	nitrite transmembrane transporter activity
KM399_10515	COG1648	precorrin-2 dehydrogenase activity
KM399_10525	COG1587	Uroporphyrinogen-III synthase
KM399_10525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KM399_10530	COG2146	nitrite reductase [NAD(P)H] activity
KM399_10535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM399_10540	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KM399_10575	COG2359	stage V sporulation protein S
KM399_10590	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM399_10605	COG1418	mRNA catabolic process
KM399_10610	COG0488	(ABC) transporter
KM399_10625	COG0629	single-stranded DNA binding
KM399_10640	COG1413	lyase activity
KM399_10655	COG2136	Putative SAM-dependent methyltransferase
KM399_10655	COG2521	methyltransferase
KM399_10660	COG0018	arginyl-trna synthetase
KM399_10685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KM399_10705	COG0017	Asparaginyl-tRNA synthetase
KM399_10725	COG1674	ftsk spoiiie
KM399_10795	COG1929	Belongs to the glycerate kinase type-1 family
KM399_10800	COG0471	metal ion transport
KM399_10805	COG0745	RESPONSE REGULATOR receiver
KM399_10810	COG5002	protein histidine kinase activity
KM399_10810	COG3850	Histidine kinase
KM399_10825	COG0733	neurotransmitter:sodium symporter activity
KM399_10850	COG2610	gluconate transmembrane transporter activity
KM399_10855	COG1454	alcohol dehydrogenase
KM399_10860	COG1794	racemase activity, acting on amino acids and derivatives
KM399_10885	COG1131	(ABC) transporter
KM399_10900	COG0546	phosphoglycolate phosphatase activity
KM399_10920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM399_10935	COG0768	penicillin binding
KM399_10940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM399_10945	COG0204	Acyl-transferase
KM399_10950	COG1272	protein, Hemolysin III
KM399_10960	COG0805	protein transport
KM399_10970	COG1307	EDD domain protein, DegV family
KM399_10975	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KM399_10980	COG1999	signal sequence binding
KM399_10985	COG0071	Belongs to the small heat shock protein (HSP20) family
KM399_10990	COG0367	asparagine synthase
KM399_11005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM399_11010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM399_11035	COG1051	belongs to the nudix hydrolase family
KM399_11045	COG0668	transmembrane transport
KM399_11050	COG2203	Gaf domain
KM399_11050	COG4585	Histidine kinase
KM399_11055	COG2197	response regulator
KM399_11065	COG1064	alcohol dehydrogenase
KM399_11090	COG1070	Carbohydrate kinase
KM399_11095	COG1070	Carbohydrate kinase
KM399_11125	COG0517	IMP dehydrogenase activity
KM399_11125	COG1125	glycine betaine transport
KM399_11130	COG1174	glycine betaine transport
KM399_11165	COG1253	flavin adenine dinucleotide binding
KM399_11170	COG1012	belongs to the aldehyde dehydrogenase family
KM399_11175	COG5506	Protein of unknown function (DUF1694)
KM399_11190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM399_11195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KM399_11200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KM399_11205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM399_11210	COG0456	acetyltransferase
KM399_11215	COG3829	transcription factor binding
KM399_11220	COG1509	lysine 2,3-aminomutase activity
KM399_11260	COG4326	sporulation control protein
KM399_11265	COG0671	phosphoesterase, PA-phosphatase related
KM399_11270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM399_11275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM399_11305	COG1787	Restriction endonuclease
KM399_11305	COG1715	Restriction endonuclease
KM399_11395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM399_11435	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM399_11435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM399_11440	COG2814	Major facilitator Superfamily
KM399_11445	COG4841	protein insertion into membrane
KM399_11450	COG0372	Belongs to the citrate synthase family
KM399_11455	COG2079	MmgE PrpD family protein
KM399_11460	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KM399_11465	COG1960	acyl-CoA dehydrogenase activity
KM399_11470	COG2084	Dehydrogenase
KM399_11480	COG1280	lysine exporter protein (LysE YggA)
KM399_11485	COG1024	Enoyl-CoA hydratase
KM399_11500	COG0420	3'-5' exonuclease activity
KM399_11505	COG0419	ATPase involved in DNA repair
KM399_11530	COG2223	nitrite transmembrane transporter activity
KM399_11535	COG1028	Short-chain dehydrogenase reductase Sdr
KM399_11540	COG1169	isochorismate synthase
KM399_11545	COG1021	2,3-dihydroxybenzoate-AMP ligase
KM399_11550	COG3433	isochorismatase activity
KM399_11550	COG1535	isochorismatase
KM399_11555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KM399_11560	COG3251	PFAM MbtH domain protein
KM399_11565	COG2814	Major facilitator Superfamily
KM399_11580	COG0776	regulation of translation
KM399_11590	COG2318	DinB family
KM399_11600	COG1115	amino acid carrier protein
KM399_11615	COG2329	Antibiotic biosynthesis monooxygenase
KM399_11620	COG1187	pseudouridine synthase activity
KM399_11625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM399_11640	COG0596	Alpha beta hydrolase
KM399_11645	COG2814	Major facilitator Superfamily
KM399_11665	COG2226	methyltransferase
KM399_11710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM399_11745	COG1247	-acetyltransferase
KM399_11775	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM399_11785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM399_11795	COG1278	Cold shock
KM399_11810	COG0010	Belongs to the arginase family
KM399_11815	COG0561	phosphatase activity
KM399_11860	COG0583	DNA-binding transcription factor activity
KM399_11865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM399_11880	COG0583	DNA-binding transcription factor activity
KM399_11885	COG2258	MOSC domain
KM399_11900	COG1132	(ABC) transporter
KM399_11905	COG1132	(ABC) transporter
KM399_11925	COG1396	sequence-specific DNA binding
KM399_11950	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
KM399_11955	COG1595	DNA-templated transcription, initiation
KM399_11980	COG1649	PFAM Uncharacterised BCR, COG1649
KM399_12005	COG2971	BadF BadG BcrA BcrD
KM399_12010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM399_12015	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KM399_12035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM399_12065	COG1309	transcriptional regulator
KM399_12080	COG0577	efflux transmembrane transporter activity
KM399_12080	COG1136	(ABC) transporter
KM399_12085	COG0500	methyltransferase
KM399_12085	COG3615	Tellurite resistance protein tehB
KM399_12095	COG2226	methyltransferase
KM399_12100	COG3961	Belongs to the TPP enzyme family
KM399_12105	COG1846	Transcriptional regulator
KM399_12145	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM399_12160	COG1595	DNA-templated transcription, initiation
KM399_12170	COG0768	penicillin binding
KM399_12180	COG2367	Beta-lactamase
KM399_12185	COG0671	phosphoesterase, PA-phosphatase related
KM399_12190	COG1609	Transcriptional regulator
KM399_12195	COG2814	Major facilitator Superfamily
KM399_12200	COG0673	inositol 2-dehydrogenase activity
KM399_12210	COG1012	belongs to the aldehyde dehydrogenase family
KM399_12225	COG0191	fructose-bisphosphate aldolase activity
KM399_12230	COG3718	enzyme involved in inositol metabolism
KM399_12255	COG0457	Tetratricopeptide repeat
KM399_12260	COG1476	TRANSCRIPTIONal
KM399_12275	COG1876	peptidase activity
KM399_12295	COG1309	transcriptional regulator
KM399_12300	COG0488	(ABC) transporter
KM399_12315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM399_12330	COG1252	NADH dehydrogenase
KM399_12335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM399_12350	COG1131	(ABC) transporter
KM399_12360	COG1309	transcriptional regulator
KM399_12375	COG1960	acyl-CoA dehydrogenase activity
KM399_12380	COG0439	Biotin carboxylase
KM399_12385	COG0511	ligase activity, forming carbon-carbon bonds
KM399_12390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KM399_12395	COG1024	Enoyl-CoA hydratase
KM399_12400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KM399_12405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM399_12415	COG1247	-acetyltransferase
KM399_12420	COG0572	uridine kinase
KM399_12430	COG2318	DinB family
KM399_12435	COG1686	Belongs to the peptidase S11 family
KM399_12460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KM399_12500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM399_12500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM399_12525	COG2814	Major facilitator Superfamily
KM399_12545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM399_12565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM399_12580	COG1063	alcohol dehydrogenase
KM399_12610	COG3773	Cell wall hydrolase
KM399_12620	COG0745	RESPONSE REGULATOR receiver
KM399_12635	COG0488	(ABC) transporter
KM399_12650	COG1136	(ABC) transporter
KM399_12675	COG0460	homoserine dehydrogenase
KM399_12680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM399_12690	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM399_12755	COG2124	cytochrome p450
KM399_12790	COG0561	phosphatase activity
KM399_12800	COG5002	protein histidine kinase activity
KM399_12805	COG0768	penicillin binding
KM399_12810	COG1819	glycosyl
KM399_12815	COG1794	racemase activity, acting on amino acids and derivatives
KM399_12825	COG1122	ATPase activity
KM399_12840	COG2205	protein histidine kinase activity
KM399_12850	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM399_12855	COG0604	alcohol dehydrogenase
KM399_12860	COG0768	penicillin binding
KM399_12870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM399_12905	COG0693	protein deglycase activity
KM399_12935	COG2814	Major facilitator Superfamily
KM399_12950	COG0584	glycerophosphoryl diester phosphodiesterase
KM399_12970	COG0697	spore germination
KM399_12995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM399_13005	COG2223	nitrite transmembrane transporter activity
KM399_13020	COG2816	NAD+ diphosphatase activity
KM399_13025	COG0592	DNA-directed DNA polymerase activity
KM399_13030	COG1051	belongs to the nudix hydrolase family
KM399_13065	COG3878	Protein conserved in bacteria
KM399_13110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM399_13125	COG0322	excinuclease ABC activity
KM399_13170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM399_13195	COG1011	Hydrolase
KM399_13215	COG0076	glutamate decarboxylase activity
KM399_13230	COG1523	belongs to the glycosyl hydrolase 13 family
KM399_13235	COG3227	Zinc metalloprotease (Elastase)
KM399_13255	COG0201	protein transport
KM399_13265	COG0697	spore germination
KM399_13270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM399_13300	COG4129	membrane
KM399_13305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM399_13320	COG2959	enzyme of heme biosynthesis
KM399_13340	COG3483	tryptophan 2,3-dioxygenase activity
KM399_13345	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KM399_13350	COG3844	kynureninase activity
KM399_13355	COG1309	transcriptional regulator
KM399_13385	COG3284	Transcriptional regulator
KM399_13405	COG1349	DNA-binding transcription factor activity
KM399_13425	COG1959	2 iron, 2 sulfur cluster binding
KM399_13440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM399_13445	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM399_13450	COG0022	dehydrogenase e1 component
KM399_13455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM399_13465	COG1028	Short-chain dehydrogenase reductase Sdr
KM399_13470	COG0456	acetyltransferase
KM399_13470	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM399_13500	COG4176	ABC-type proline glycine betaine transport system permease component
KM399_13505	COG4175	Glycine betaine
KM399_13505	COG0517	IMP dehydrogenase activity
KM399_13530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KM399_13535	COG2153	protein acetylation
KM399_13540	COG3397	chitin binding
KM399_13555	COG2205	protein histidine kinase activity
KM399_13580	COG0658	competence protein
KM399_13580	COG2333	competence protein COMEC
KM399_13630	COG3973	AAA domain
KM399_13645	COG2105	PFAM AIG2 family protein
KM399_13650	COG0514	ATP-dependent DNA helicase (RecQ)
KM399_13670	COG4637	Psort location Cytoplasmic, score
KM399_13695	COG3397	chitin binding
KM399_13710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KM399_13715	COG1115	amino acid carrier protein
KM399_13720	COG1012	belongs to the aldehyde dehydrogenase family
KM399_13725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KM399_13735	COG3938	Belongs to the proline racemase family
KM399_13740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM399_13780	COG0586	Pfam SNARE associated Golgi protein
KM399_13795	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM399_13800	COG0519	Catalyzes the synthesis of GMP from XMP
KM399_13805	COG4166	transmembrane transport
KM399_13815	COG4948	Mandelate Racemase Muconate Lactonizing
KM399_13860	COG2936	dipeptidyl-peptidase activity
KM399_13865	COG5002	protein histidine kinase activity
KM399_13905	COG1164	Oligoendopeptidase f
KM399_13920	COG1307	EDD domain protein, DegV family
KM399_13940	COG2814	Major facilitator Superfamily
KM399_13950	COG1664	Polymer-forming cytoskeletal
KM399_13955	COG0789	Transcriptional regulator
KM399_13960	COG4533	DNA binding
KM399_13965	COG0477	Major facilitator Superfamily
KM399_13965	COG2814	Major facilitator Superfamily
KM399_13985	COG2261	transglycosylase associated protein
KM399_14000	COG2226	methyltransferase
KM399_14035	COG0436	Aminotransferase
KM399_14040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KM399_14045	COG5146	pantothenate kinase activity
KM399_14065	COG1131	(ABC) transporter
KM399_14110	COG0628	permease
KM399_14120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM399_14125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM399_14130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM399_14135	COG1116	anion transmembrane transporter activity
KM399_14155	COG2816	NAD+ diphosphatase activity
KM399_14175	COG2746	aminoglycoside 3-N-acetyltransferase activity
KM399_14200	COG0697	spore germination
KM399_14205	COG2318	DinB family
KM399_14225	COG4912	Dna alkylation repair
KM399_14245	COG0861	Integral membrane protein TerC family
KM399_14250	COG1368	sulfuric ester hydrolase activity
KM399_14255	COG0488	(ABC) transporter
KM399_14265	COG1033	growth of symbiont in host cell
KM399_14265	COG2409	Drug exporters of the RND superfamily
KM399_14270	COG1033	growth of symbiont in host cell
KM399_14270	COG2409	Drug exporters of the RND superfamily
KM399_14275	COG2409	Drug exporters of the RND superfamily
KM399_14275	COG1033	growth of symbiont in host cell
KM399_14280	COG1309	transcriptional regulator
KM399_14295	COG0287	Prephenate dehydrogenase
KM399_14300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM399_14305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KM399_14310	COG1605	Chorismate mutase
KM399_14310	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KM399_14345	COG1388	LysM domain
KM399_14345	COG3584	3D domain protein
KM399_14355	COG1595	DNA-templated transcription, initiation
KM399_14380	COG1879	ABC-type sugar transport system periplasmic component
KM399_14390	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM399_14400	COG2390	Transcriptional regulator
KM399_14435	COG2329	Antibiotic biosynthesis monooxygenase
KM399_14455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM399_14465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KM399_14470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM399_14475	COG4187	Peptidase family M20/M25/M40
KM399_14480	COG1414	Transcriptional regulator
KM399_14485	COG0833	amino acid
KM399_14490	COG1690	Belongs to the RtcB family
KM399_14495	COG3239	Fatty acid desaturase
KM399_14500	COG1785	Belongs to the alkaline phosphatase family
KM399_14510	COG3655	Transcriptional regulator
KM399_14525	COG4377	Putative membrane peptidase family (DUF2324)
KM399_14535	COG3279	Response regulator of the LytR AlgR family
KM399_14545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM399_14550	COG0346	lactoylglutathione lyase activity
KM399_14570	COG0714	Associated with various cellular activities
KM399_14595	COG0463	Glycosyl transferase, family 2
KM399_14620	COG0463	Glycosyl transferase, family 2
KM399_14630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM399_14635	COG0753	catalase activity
KM399_14645	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KM399_14670	COG0714	Associated with various cellular activities
KM399_14680	COG0778	Nitroreductase
KM399_14685	COG1846	Transcriptional regulator
KM399_14720	COG1725	Transcriptional regulator
KM399_14730	COG1136	(ABC) transporter
KM399_14730	COG0577	efflux transmembrane transporter activity
KM399_14755	COG2207	Transcriptional regulator
KM399_14760	COG0456	acetyltransferase
KM399_14780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM399_14800	COG0642	Histidine kinase
KM399_14805	COG0745	RESPONSE REGULATOR receiver
KM399_14810	COG0596	Alpha beta hydrolase
KM399_14840	COG0730	response to heat
KM399_14850	COG0833	amino acid
KM399_14860	COG4335	DNA alkylation repair
KM399_14900	COG0768	penicillin binding
KM399_14910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KM399_14940	COG1984	allophanate hydrolase subunit 2
KM399_14945	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KM399_14950	COG1414	Transcriptional regulator
KM399_14965	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM399_14970	COG0640	Transcriptional regulator
KM399_14980	COG1960	acyl-CoA dehydrogenase activity
KM399_15000	COG3314	Sporulation integral membrane protein YlbJ
KM399_15015	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KM399_15030	COG0574	Belongs to the PEP-utilizing enzyme family
KM399_15030	COG3848	Pyruvate phosphate dikinase
KM399_15035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM399_15050	COG5577	PFAM Coat F domain
KM399_15055	COG3403	YqcI/YcgG family
KM399_15060	COG1280	lysine exporter protein (LysE YggA)
KM399_15095	COG1063	alcohol dehydrogenase
KM399_15110	COG1027	Aspartate ammonia-lyase
KM399_15115	COG0252	asparaginase activity
KM399_15120	COG1396	sequence-specific DNA binding
KM399_15130	COG0322	excinuclease ABC activity
KM399_15135	COG0531	amino acid
KM399_15140	COG1114	Component of the transport system for branched-chain amino acids
KM399_15145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM399_15155	COG0281	malic enzyme
KM399_15170	COG0531	amino acid
KM399_15180	COG0784	Response regulator, receiver
KM399_15190	COG2066	Belongs to the glutaminase family
KM399_15195	COG1115	amino acid carrier protein
KM399_15225	COG0737	Belongs to the 5'-nucleotidase family
KM399_15230	COG0753	catalase activity
KM399_15235	COG2267	carboxylic ester hydrolase activity
KM399_15240	COG1335	isochorismatase
KM399_15260	COG0583	DNA-binding transcription factor activity
KM399_15265	COG1846	Transcriptional regulator
KM399_15305	COG0415	Belongs to the DNA photolyase family
KM399_15310	COG0288	reversible hydration of carbon dioxide
KM399_15320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM399_15325	COG5609	conserved protein (DUF2294)
KM399_15340	COG1575	Belongs to the MenA family. Type 1 subfamily
KM399_15345	COG2267	carboxylic ester hydrolase activity
KM399_15350	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM399_15355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM399_15360	COG1121	(ABC) transporter
KM399_15390	COG0798	PFAM Bile acid sodium symporter
KM399_15395	COG0346	lactoylglutathione lyase activity
KM399_15400	COG0640	Transcriptional regulator
KM399_15415	COG0443	Heat shock 70 kDa protein
KM399_15430	COG1522	sequence-specific DNA binding
KM399_15445	COG0346	lactoylglutathione lyase activity
KM399_15470	COG2169	Transcriptional regulator
KM399_15515	COG2814	Major facilitator Superfamily
KM399_15540	COG0745	RESPONSE REGULATOR receiver
KM399_15545	COG3850	Histidine kinase
KM399_15545	COG5002	protein histidine kinase activity
KM399_15570	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KM399_15590	COG1476	TRANSCRIPTIONal
KM399_15605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM399_15610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM399_15620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM399_15625	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KM399_15640	COG1136	(ABC) transporter
KM399_15645	COG0577	efflux transmembrane transporter activity
KM399_15660	COG3850	Histidine kinase
KM399_15660	COG5002	protein histidine kinase activity
KM399_15670	COG2364	Membrane
KM399_15675	COG1846	Transcriptional regulator
KM399_15685	COG2808	Putative FMN-binding domain
KM399_15690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM399_15695	COG2271	Major facilitator Superfamily
KM399_15700	COG1556	Lactate utilization protein
KM399_15705	COG1139	Iron-sulfur cluster binding protein
KM399_15715	COG0583	DNA-binding transcription factor activity
KM399_15725	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM399_15750	COG0738	Major facilitator superfamily
KM399_15755	COG0673	inositol 2-dehydrogenase activity
KM399_15760	COG0561	phosphatase activity
KM399_15770	COG1609	Transcriptional regulator
KM399_15775	COG0457	Tetratricopeptide repeat
KM399_15795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM399_15825	COG0534	Mate efflux family protein
KM399_15845	COG2814	Major facilitator Superfamily
KM399_15850	COG1309	transcriptional regulator
KM399_15865	COG0814	amino acid
KM399_15870	COG1760	l-serine dehydratase
KM399_15875	COG1760	l-serine dehydratase
KM399_15885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM399_15890	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KM399_15900	COG1335	isochorismatase
KM399_15905	COG1522	sequence-specific DNA binding
KM399_15910	COG0531	amino acid
KM399_15925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KM399_15945	COG1595	DNA-templated transcription, initiation
KM399_15960	COG0662	Cupin 2, conserved barrel domain protein
KM399_15965	COG2207	Transcriptional regulator
KM399_15965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM399_16015	COG0477	Major facilitator Superfamily
KM399_16025	COG1846	Transcriptional regulator
KM399_16030	COG2814	Major facilitator Superfamily
KM399_16040	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM399_16045	COG1131	(ABC) transporter
KM399_16065	COG2076	Multidrug Resistance protein
KM399_16070	COG1309	transcriptional regulator
KM399_16080	COG2031	fatty acid transporter
KM399_16090	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM399_16120	COG1122	ATPase activity
KM399_16125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM399_16140	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KM399_16145	COG1288	antiporter activity
KM399_16150	COG2356	endonuclease I
KM399_16165	COG3620	sequence-specific DNA binding
KM399_16170	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM399_16175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KM399_16180	COG0124	histidyl-tRNA synthetase
KM399_16195	COG1733	regulation of RNA biosynthetic process
KM399_16200	COG0778	Nitroreductase
KM399_16220	COG1028	Short-chain dehydrogenase reductase Sdr
KM399_16230	COG1131	(ABC) transporter
KM399_16255	COG1011	Hydrolase
KM399_16265	COG2365	Tyrosine phosphatase family
KM399_16290	COG0346	lactoylglutathione lyase activity
KM399_16295	COG1940	carbohydrate kinase activity
KM399_16300	COG0738	Major facilitator superfamily
KM399_16305	COG0110	maltose O-acetyltransferase activity
KM399_16315	COG0577	efflux transmembrane transporter activity
KM399_16315	COG1136	(ABC) transporter
KM399_16330	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KM399_16335	COG0628	permease
KM399_16355	COG2226	methyltransferase
KM399_16365	COG0477	Major facilitator Superfamily
KM399_16395	COG1253	flavin adenine dinucleotide binding
KM399_16400	COG0789	Transcriptional regulator
KM399_16405	COG0697	spore germination
KM399_16410	COG1357	PFAM Pentapeptide repeats (8 copies)
KM399_16415	COG3813	Protein conserved in bacteria
KM399_16420	COG2706	6-phosphogluconolactonase activity
KM399_16425	COG1070	Carbohydrate kinase
KM399_16435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KM399_16440	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KM399_16450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM399_16455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM399_16460	COG0604	alcohol dehydrogenase
KM399_16465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM399_16475	COG3321	synthase
KM399_16475	COG0604	alcohol dehydrogenase
KM399_16480	COG1028	Short-chain dehydrogenase reductase Sdr
KM399_16505	COG0656	L-ascorbic acid biosynthetic process
KM399_16510	COG2814	Major facilitator Superfamily
KM399_16525	COG0346	lactoylglutathione lyase activity
KM399_16530	COG0814	amino acid
KM399_16555	COG1393	Belongs to the ArsC family
KM399_16560	COG1733	regulation of RNA biosynthetic process
KM399_16565	COG2188	Transcriptional regulator
KM399_16575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KM399_16580	COG1733	regulation of RNA biosynthetic process
KM399_16585	COG1733	regulation of RNA biosynthetic process
KM399_16600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM399_16620	COG0384	phenazine biosynthesis protein PhzF
KM399_16630	COG1028	Short-chain dehydrogenase reductase Sdr
KM399_16640	COG0318	PFAM AMP-dependent synthetase and ligase
KM399_16650	COG1733	regulation of RNA biosynthetic process
KM399_16685	COG1191	sigma factor activity
KM399_16700	COG1309	transcriptional regulator
KM399_16720	COG3152	Membrane
KM399_16745	COG1151	hydroxylamine reductase activity
KM399_16755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM399_16760	COG3757	hydrolase, family 25
KM399_16760	COG3409	Peptidoglycan-binding domain 1 protein
KM399_16795	COG2072	flavoprotein involved in K transport
KM399_16830	COG0604	alcohol dehydrogenase
KM399_16835	COG1113	amino acid transport
KM399_16840	COG2814	Major facilitator Superfamily
KM399_16870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM399_16875	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM399_16895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM399_16900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM399_16905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM399_16910	COG3739	integral membrane protein
KM399_16915	COG0384	phenazine biosynthesis protein PhzF
KM399_16945	COG0583	DNA-binding transcription factor activity
KM399_16965	COG1193	negative regulation of DNA recombination
KM399_16990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM399_17020	COG0584	glycerophosphoryl diester phosphodiesterase
KM399_17045	COG0640	Transcriptional regulator
KM399_17050	COG0604	alcohol dehydrogenase
KM399_17070	COG2808	Putative FMN-binding domain
KM399_17075	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM399_17085	COG0385	Bile acid
KM399_17090	COG0277	FAD linked oxidase domain protein
KM399_17125	COG1024	Enoyl-CoA hydratase
KM399_17135	COG1285	pathogenesis
KM399_17150	COG2514	catechol 2,3-dioxygenase activity
KM399_17155	COG2720	vancomycin resistance protein
KM399_17195	COG0716	FMN binding
KM399_17225	COG1028	Short-chain dehydrogenase reductase Sdr
KM399_17235	COG0165	Argininosuccinate lyase
KM399_17250	COG4145	pantothenate transmembrane transporter activity
KM399_17260	COG1012	belongs to the aldehyde dehydrogenase family
KM399_17265	COG1028	Short-chain dehydrogenase reductase Sdr
KM399_17275	COG1657	PFAM Prenyltransferase squalene oxidase
KM399_17280	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KM399_17285	COG2962	Rard protein
KM399_17290	COG3326	Membrane
KM399_17305	COG0489	protein tyrosine kinase activity
KM399_17315	COG0314	molybdopterin synthase activity
KM399_17320	COG0303	'Molybdopterin
KM399_17325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM399_17330	COG2116	formate transmembrane transporter activity
KM399_17340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM399_17345	COG5609	conserved protein (DUF2294)
KM399_17350	COG2427	Protein of unknown function (DUF1641)
KM399_17365	COG0697	spore germination
KM399_17405	COG2226	methyltransferase
KM399_17410	COG4166	transmembrane transport
KM399_17415	COG4166	transmembrane transport
KM399_17420	COG4166	transmembrane transport
KM399_17425	COG1301	dicarboxylic acid transport
KM399_17430	COG1316	TRANSCRIPTIONal
KM399_17440	COG1595	DNA-templated transcription, initiation
KM399_17460	COG1131	(ABC) transporter
KM399_17470	COG0673	inositol 2-dehydrogenase activity
KM399_17475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM399_17480	COG0187	DNA topoisomerase II activity
KM399_17485	COG1832	CoA-binding protein
KM399_17490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM399_17495	COG0745	RESPONSE REGULATOR receiver
KM399_17510	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM399_17515	COG4841	protein insertion into membrane
KM399_17520	COG0824	Thioesterase
KM399_17550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM399_17560	COG2274	protein secretion by the type I secretion system
KM399_17565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KM399_17605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM399_17620	COG0183	Belongs to the thiolase family
KM399_17625	COG0318	PFAM AMP-dependent synthetase and ligase
KM399_17630	COG1268	BioY protein
KM399_17635	COG0318	PFAM AMP-dependent synthetase and ligase
KM399_17685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM399_17695	COG5002	protein histidine kinase activity
KM399_17700	COG0400	carboxylic ester hydrolase activity
KM399_17705	COG0346	lactoylglutathione lyase activity
KM399_17710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM399_17715	COG0069	glutamate synthase activity
KM399_17720	COG1902	pentaerythritol trinitrate reductase activity
KM399_17725	COG1329	Transcriptional regulator
KM399_17730	COG0010	Belongs to the arginase family
KM399_17755	COG2226	methyltransferase
KM399_17810	COG4846	Membrane protein involved in cytochrome C biogenesis
KM399_17815	COG0785	Cytochrome C biogenesis protein
KM399_17825	COG0583	DNA-binding transcription factor activity
KM399_17830	COG1380	Effector of murein hydrolase LrgA
KM399_17835	COG1346	cytolysis
KM399_17860	COG3409	Peptidoglycan-binding domain 1 protein
KM399_17860	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM399_17875	COG1132	(ABC) transporter
KM399_17880	COG1132	(ABC) transporter
KM399_17910	COG3639	organic phosphonate transmembrane transporter activity
KM399_17915	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KM399_17935	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KM399_17955	COG1695	Transcriptional regulator
KM399_17995	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM399_17995	COG1388	LysM domain
KM399_17995	COG3409	Peptidoglycan-binding domain 1 protein
KM399_18000	COG4824	toxin secretion phage lysis holin
KM399_18155	COG1595	DNA-templated transcription, initiation
KM399_18200	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KM399_18285	COG1396	sequence-specific DNA binding
KM399_18310	COG0174	glutamine synthetase
KM399_18315	COG0789	Transcriptional regulator
KM399_18320	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KM399_18330	COG2860	membrane
KM399_18340	COG0464	growth
KM399_18370	COG3584	3D domain protein
KM399_18370	COG1388	LysM domain
KM399_18375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM399_18375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM399_18375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM399_18380	COG1105	Belongs to the carbohydrate kinase PfkB family
KM399_18385	COG1349	DNA-binding transcription factor activity
KM399_18395	COG2322	membrane
KM399_18405	COG1113	amino acid transport
KM399_18420	COG1408	metallophosphoesterase
KM399_18425	COG2116	formate transmembrane transporter activity
KM399_18435	COG2217	Heavy metal translocating P-type atpase
KM399_18440	COG2608	mercury ion transmembrane transporter activity
KM399_18445	COG1937	Protein conserved in bacteria
KM399_18455	COG2819	hydrolase of the alpha beta superfamily
KM399_18460	COG1120	ATPase activity
KM399_18465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM399_18470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM399_18480	COG0708	Exodeoxyribonuclease III
KM399_18485	COG2169	Transcriptional regulator
KM399_18490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM399_18495	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM399_18505	COG2364	Membrane
KM399_18520	COG2267	carboxylic ester hydrolase activity
KM399_18525	COG0346	lactoylglutathione lyase activity
KM399_18530	COG5001	Diguanylate cyclase
KM399_18530	COG3300	MHYT domain
KM399_18545	COG1346	cytolysis
KM399_18550	COG1380	Effector of murein hydrolase LrgA
KM399_18555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM399_18560	COG0596	Alpha beta hydrolase
KM399_18560	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM399_18565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM399_18585	COG1404	Belongs to the peptidase S8 family
KM399_18590	COG3773	Cell wall hydrolase
KM399_18595	COG0562	UDP-galactopyranose mutase
KM399_18600	COG1368	sulfuric ester hydrolase activity
KM399_18605	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM399_18615	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KM399_18640	COG1131	(ABC) transporter
KM399_18660	COG4550	Control of competence regulator ComK, YlbF/YmcA
KM399_18665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM399_18670	COG1013	pyruvate-flavodoxin oxidoreductase activity
KM399_18675	COG0674	pyruvate-flavodoxin oxidoreductase activity
KM399_18675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KM399_18685	COG2359	stage V sporulation protein S
KM399_18690	COG1692	metallophosphoesterase
KM399_18715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KM399_18720	COG1426	Protein conserved in bacteria
KM399_18735	COG0300	oxidoreductase activity
KM399_18740	COG0612	Peptidase, M16
KM399_18745	COG0612	Peptidase, M16
KM399_18750	COG1079	Belongs to the binding-protein-dependent transport system permease family
KM399_18760	COG3845	ABC transporter
KM399_18765	COG1744	ABC transporter substrate-binding protein PnrA-like
KM399_18770	COG2188	Transcriptional regulator
KM399_18775	COG1674	ftsk spoiiie
KM399_18785	COG0740	serine-type endopeptidase activity
KM399_18790	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM399_18800	COG0527	aspartate kinase activity
KM399_18805	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM399_18810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM399_18815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM399_18820	COG1873	PFAM PRC-barrel domain
KM399_18825	COG0612	Peptidase, M16
KM399_18830	COG0726	polysaccharide deacetylase
KM399_18845	COG0196	riboflavin kinase activity
KM399_18850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KM399_18860	COG1550	Protein conserved in bacteria
KM399_18870	COG1358	cellular component organization or biogenesis
KM399_18875	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KM399_18880	COG0195	Participates in both transcription termination and antitermination
KM399_18900	COG0750	zinc metalloprotease
KM399_18910	COG4589	Belongs to the CDS family
KM399_18915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KM399_18925	COG0528	UMP kinase activity
KM399_18955	COG4974	Belongs to the 'phage' integrase family
KM399_18965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM399_18975	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KM399_19015	COG1837	Belongs to the UPF0109 family
KM399_19025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KM399_19035	COG0552	protein localization to endoplasmic reticulum
KM399_19040	COG1196	nuclear chromosome segregation
KM399_19050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM399_19055	COG1028	Short-chain dehydrogenase reductase Sdr
KM399_19060	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KM399_19075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KM399_19080	COG1461	Dihydroxyacetone kinase
KM399_19085	COG1302	Protein conserved in bacteria
KM399_19100	COG1564	THIamine pyrophosphokinase
KM399_19105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KM399_19110	COG1162	GTPase activity
KM399_19115	COG0515	serine threonine protein kinase
KM399_19115	COG2815	serine threonine protein kinase
KM399_19120	COG0631	protein serine/threonine phosphatase activity
KM399_19130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KM399_19130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KM399_19140	COG0242	peptide deformylase activity
KM399_19145	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KM399_19150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM399_19170	COG1561	YicC-like family, N-terminal region
KM399_19175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KM399_19185	COG0006	proline dipeptidase activity
KM399_19200	COG3069	C4-dicarboxylate transmembrane transporter activity
KM399_19265	COG0564	pseudouridine synthase activity
KM399_19285	COG3599	regulation of cell shape
KM399_19290	COG2302	S4 RNA-binding domain
KM399_19295	COG0762	integral membrane protein
KM399_19305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KM399_19310	COG1496	oxidoreductase activity
KM399_19315	COG1873	PFAM PRC-barrel domain
KM399_19320	COG1191	sigma factor activity
KM399_19325	COG1191	sigma factor activity
KM399_19335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KM399_19340	COG0849	cell division
KM399_19345	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KM399_19350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM399_19360	COG0772	Belongs to the SEDS family
KM399_19375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KM399_19380	COG0768	penicillin binding
KM399_19385	COG0768	penicillin binding
KM399_19390	COG4839	cell division protein FtsL
KM399_19405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM399_19420	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KM399_19425	COG1399	metal-binding, possibly nucleic acid-binding protein
KM399_19475	COG4824	toxin secretion phage lysis holin
KM399_19560	COG4626	Terminase
KM399_19560	COG1802	Transcriptional regulator
KM399_19585	COG0582	viral genome integration into host DNA
KM399_19650	COG0756	dUTP diphosphatase activity
KM399_19665	COG1191	sigma factor activity
KM399_19690	COG1484	DNA-dependent DNA replication
KM399_19720	COG1396	sequence-specific DNA binding
KM399_19735	COG1396	sequence-specific DNA binding
KM399_19750	COG0582	viral genome integration into host DNA
KM399_19760	COG3480	Lon protease (S16) C-terminal proteolytic domain
KM399_19765	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM399_19770	COG3314	Sporulation integral membrane protein YlbJ
KM399_19780	COG0742	ribosomal rna small subunit methyltransferase
KM399_19795	COG3679	Belongs to the UPF0342 family
KM399_19800	COG0406	alpha-ribazole phosphatase activity
KM399_19815	COG2340	Cysteine-rich secretory protein family
KM399_19830	COG3336	cytochrome c oxidase
KM399_19865	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KM399_19870	COG0772	Belongs to the SEDS family
KM399_19880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KM399_19885	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KM399_19895	COG4896	Protein conserved in bacteria
KM399_19910	COG1217	gtp-binding protein TYPA
KM399_19920	COG0483	inositol monophosphate 1-phosphatase activity
KM399_19940	COG1982	Orn Lys Arg decarboxylase major
KM399_19985	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM399_19990	COG0022	dehydrogenase e1 component
KM399_19995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM399_20005	COG0242	peptide deformylase activity
KM399_20010	COG0561	phosphatase activity
KM399_20020	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM399_20025	COG0569	domain protein
KM399_20045	COG0583	DNA-binding transcription factor activity
KM399_20050	COG0517	IMP dehydrogenase activity
KM399_20060	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
KM399_20070	COG4703	Protein of unknown function (DUF1797)
KM399_20085	COG2200	EAL domain
KM399_20090	COG1028	Short-chain dehydrogenase reductase Sdr
KM399_20095	COG1408	metallophosphoesterase
KM399_20105	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KM399_20140	COG2814	Major facilitator Superfamily
KM399_20160	COG3209	COG3209 Rhs family protein
KM399_20170	COG2205	protein histidine kinase activity
KM399_20180	COG0436	Aminotransferase
KM399_20185	COG1609	Transcriptional regulator
KM399_20190	COG3833	ABC-type maltose transport systems, permease component
KM399_20195	COG1175	transmembrane transport
KM399_20200	COG2182	Extracellular solute-binding protein
KM399_20210	COG0366	Alpha amylase catalytic
KM399_20215	COG3842	ATPase activity
KM399_20255	COG0183	Belongs to the thiolase family
KM399_20290	COG1695	Transcriptional regulator
KM399_20295	COG1028	Short-chain dehydrogenase reductase Sdr
KM399_20305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KM399_20315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KM399_20320	COG0436	Aminotransferase
KM399_20340	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KM399_20360	COG2199	diguanylate cyclase activity
KM399_20365	COG0778	Nitroreductase
KM399_20390	COG2190	(PTS) system
KM399_20390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM399_20390	COG1263	PTS System
KM399_20395	COG3711	transcriptional antiterminator
KM399_20405	COG2188	Transcriptional regulator
KM399_20415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KM399_20440	COG1547	Domain of unknown function (DUF309)
KM399_20445	COG0456	acetyltransferase
KM399_20450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KM399_20455	COG4086	secreted protein
KM399_20460	COG0561	phosphatase activity
KM399_20465	COG0697	spore germination
KM399_20480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM399_20505	COG0733	neurotransmitter:sodium symporter activity
KM399_20525	COG1686	Belongs to the peptidase S11 family
KM399_20530	COG1725	Transcriptional regulator
KM399_20535	COG1131	(ABC) transporter
KM399_20550	COG1846	Transcriptional regulator
KM399_20565	COG0598	Magnesium transport protein CorA
KM399_20590	COG4974	Belongs to the 'phage' integrase family
KM399_20600	COG0735	belongs to the Fur family
KM399_20605	COG1300	Membrane
KM399_20625	COG0667	Aldo Keto reductase
KM399_20630	COG0656	L-ascorbic acid biosynthetic process
KM399_20635	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM399_20635	COG0456	acetyltransferase
KM399_20645	COG1525	nuclease
KM399_20645	COG0737	Belongs to the 5'-nucleotidase family
KM399_20645	COG4085	toxin activity
KM399_20655	COG0596	Alpha beta hydrolase
KM399_20660	COG2056	Na+-H+ antiporter family
KM399_20670	COG0456	acetyltransferase
KM399_20675	COG1073	alpha beta
KM399_20690	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM399_20690	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM399_20695	COG0307	riboflavin synthase, alpha
KM399_20720	COG4106	trans-aconitate 2-methyltransferase activity
KM399_20725	COG1073	alpha beta
KM399_20725	COG2226	methyltransferase
KM399_20740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM399_20750	COG1757	Na H antiporter
KM399_20755	COG0737	Belongs to the 5'-nucleotidase family
KM399_20765	COG1522	sequence-specific DNA binding
KM399_20785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM399_20795	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KM399_20810	COG0300	oxidoreductase activity
KM399_20820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM399_20825	COG1760	l-serine dehydratase
KM399_20830	COG1760	l-serine dehydratase
KM399_20850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM399_20860	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM399_20865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM399_20880	COG1376	ErfK ybiS ycfS ynhG family protein
KM399_20885	COG4129	membrane
KM399_20890	COG1126	abc transporter atp-binding protein
KM399_20895	COG0765	amino acid transport
KM399_20900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM399_20920	COG0772	Belongs to the SEDS family
KM399_20925	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM399_20930	COG0022	dehydrogenase e1 component
KM399_20935	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM399_20940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM399_20955	COG0280	phosphate acetyltransferase
KM399_20960	COG3290	protein histidine kinase activity
KM399_20960	COG3829	transcription factor binding
KM399_20970	COG0584	glycerophosphoryl diester phosphodiesterase
KM399_20975	COG3093	addiction module antidote protein HigA
KM399_20985	COG0745	RESPONSE REGULATOR receiver
KM399_20990	COG0750	zinc metalloprotease
KM399_20995	COG0497	DNA recombination
KM399_21005	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KM399_21015	COG0142	geranyltranstransferase activity
KM399_21040	COG1302	Protein conserved in bacteria
KM399_21045	COG0439	Biotin carboxylase
KM399_21050	COG0511	ligase activity, forming carbon-carbon bonds
KM399_21095	COG3854	ATPases associated with a variety of cellular activities
KM399_21120	COG0006	proline dipeptidase activity
KM399_21135	COG3872	metal-dependent enzyme
KM399_21145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KM399_21165	COG0095	Lipoate-protein ligase
KM399_21170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM399_21175	COG1609	Transcriptional regulator
KM399_21185	COG2076	Multidrug Resistance protein
KM399_21190	COG2076	Multidrug Resistance protein
KM399_21225	COG1131	(ABC) transporter
KM399_21230	COG1725	Transcriptional regulator
KM399_21260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM399_21315	COG4970	Tfp pilus assembly protein FimT
KM399_21325	COG1459	type II secretion system
KM399_21330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KM399_21380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KM399_21385	COG0646	methionine synthase
KM399_21385	COG1410	methionine synthase
KM399_21390	COG0646	methionine synthase
KM399_21390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KM399_21395	COG0626	cystathionine gamma-synthase activity
KM399_21400	COG0626	cystathionine gamma-synthase activity
KM399_21420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM399_21430	COG1940	carbohydrate kinase activity
KM399_21435	COG4483	Protein conserved in bacteria
KM399_21440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KM399_21445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KM399_21450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KM399_21455	COG0704	Plays a role in the regulation of phosphate uptake
KM399_21465	COG0581	inorganic phosphate transmembrane transporter activity
KM399_21470	COG0573	inorganic phosphate transmembrane transporter activity
KM399_21475	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM399_21480	COG0768	penicillin binding
KM399_21485	COG0477	Major facilitator Superfamily
KM399_21490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM399_21515	COG0735	belongs to the Fur family
KM399_21520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM399_21525	COG1121	(ABC) transporter
KM399_21530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM399_21560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM399_21565	COG2384	SAM-dependent methyltransferase
KM399_21570	COG2010	Cytochrome c
KM399_21575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM399_21580	COG0358	DNA primase activity
KM399_21590	COG0517	IMP dehydrogenase activity
KM399_21605	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KM399_21610	COG0295	cytidine deaminase activity
KM399_21615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KM399_21625	COG1480	7TM receptor with intracellular HD hydrolase
KM399_21630	COG1702	phosphate starvation-inducible protein PhoH
KM399_21645	COG1610	YqeY-like protein
KM399_21650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KM399_21655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM399_21660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KM399_21690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM399_21695	COG1733	regulation of RNA biosynthetic process
KM399_21720	COG1466	dna polymerase III delta subunit
KM399_21730	COG2333	competence protein COMEC
KM399_21730	COG0658	competence protein
KM399_21735	COG2131	deaminase
KM399_21740	COG1596	polysaccharide export
KM399_21740	COG1555	photosystem II stabilization
KM399_21745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM399_21750	COG2226	methyltransferase
KM399_21755	COG0799	negative regulation of ribosome biogenesis
KM399_21760	COG1713	HD superfamily hydrolase involved in NAD metabolism
KM399_21770	COG1534	Rna-binding protein
KM399_21780	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KM399_21785	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KM399_21810	COG1595	DNA-templated transcription, initiation
KM399_21820	COG0778	Nitroreductase
KM399_21825	COG2357	RelA SpoT domain protein
KM399_21835	COG1785	Belongs to the alkaline phosphatase family
KM399_21845	COG2267	carboxylic ester hydrolase activity
KM399_21880	COG1404	Belongs to the peptidase S8 family
KM399_21885	COG3186	Phenylalanine-4-hydroxylase
KM399_21900	COG2259	Doxx family
KM399_21940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM399_21950	COG1012	belongs to the aldehyde dehydrogenase family
KM399_21950	COG1454	alcohol dehydrogenase
KM399_21955	COG0626	cystathionine gamma-synthase activity
KM399_21960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM399_21985	COG0768	penicillin binding
KM399_22000	COG0826	peptidase U32
KM399_22005	COG0826	peptidase U32
KM399_22010	COG4122	O-methyltransferase activity
KM399_22015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KM399_22035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM399_22045	COG0628	permease
KM399_22065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KM399_22075	COG0482	sulfurtransferase activity
KM399_22080	COG1104	cysteine desulfurase activity
KM399_22085	COG1959	2 iron, 2 sulfur cluster binding
KM399_22090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KM399_22100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KM399_22125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KM399_22135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KM399_22135	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KM399_22140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM399_22145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM399_22145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM399_22155	COG2244	polysaccharide biosynthetic process
KM399_22160	COG2323	membrane
KM399_22170	COG1862	Preprotein translocase
KM399_22200	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KM399_22210	COG0697	spore germination
KM399_22215	COG0697	spore germination
KM399_22220	COG0640	Transcriptional regulator
KM399_22245	COG0157	Belongs to the NadC ModD family
KM399_22250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KM399_22255	COG1104	cysteine desulfurase activity
KM399_22260	COG1827	regulation of RNA biosynthetic process
KM399_22265	COG2258	MOSC domain
KM399_22270	COG0077	Prephenate dehydratase
KM399_22275	COG0577	efflux transmembrane transporter activity
KM399_22280	COG0577	efflux transmembrane transporter activity
KM399_22285	COG1136	(ABC) transporter
KM399_22295	COG0745	RESPONSE REGULATOR receiver
KM399_22300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KM399_22305	COG3290	protein histidine kinase activity
KM399_22315	COG2868	ribosomal protein
KM399_22325	COG1530	ribonuclease E activity
KM399_22330	COG1994	Peptidase M50
KM399_22335	COG0739	heme binding
KM399_22340	COG2894	cell division
KM399_22360	COG1077	Cell shape determining protein MreB Mrl
KM399_22380	COG0285	dihydrofolate synthase activity
KM399_22385	COG0525	valine-tRNA ligase activity
KM399_22395	COG1388	LysM domain
KM399_22405	COG0113	porphobilinogen synthase activity
KM399_22410	COG1587	Uroporphyrinogen-III synthase
KM399_22420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM399_22430	COG1846	Transcriptional regulator
KM399_22435	COG1764	response to oxidative stress
KM399_22450	COG1067	ATP-dependent peptidase activity
KM399_22450	COG0470	DNA polymerase III
KM399_22495	COG0622	Phosphoesterase
KM399_22510	COG5401	PFAM Sporulation and spore germination
KM399_22530	COG1309	transcriptional regulator
KM399_22545	COG2197	response regulator
KM399_22550	COG2233	PERMEase
KM399_22560	COG0402	S-adenosylhomocysteine deaminase activity
KM399_22565	COG0402	S-adenosylhomocysteine deaminase activity
KM399_22575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM399_22585	COG0444	Belongs to the ABC transporter superfamily
KM399_22590	COG4608	Belongs to the ABC transporter superfamily
KM399_22595	COG3275	phosphorelay sensor kinase activity
KM399_22600	COG3279	Response regulator of the LytR AlgR family
KM399_22615	COG1983	PspC domain protein
KM399_22620	COG1396	sequence-specific DNA binding
KM399_22625	COG0697	spore germination
KM399_22635	COG1959	2 iron, 2 sulfur cluster binding
KM399_22640	COG1668	transmembrane transport
KM399_22645	COG4152	abc transporter atp-binding protein
KM399_22650	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KM399_22660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM399_22665	COG1876	peptidase activity
KM399_22670	COG0824	Thioesterase
KM399_22675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KM399_22680	COG1053	succinate dehydrogenase
KM399_22685	COG2009	succinate dehydrogenase
KM399_22690	COG1719	4-vinyl reductase, 4VR
KM399_22700	COG3118	belongs to the thioredoxin family
KM399_22705	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KM399_22710	COG2086	electron transfer activity
KM399_22715	COG1024	Enoyl-CoA hydratase
KM399_22720	COG1309	transcriptional regulator
KM399_22725	COG0318	PFAM AMP-dependent synthetase and ligase
KM399_22745	COG2318	DinB family
KM399_22775	COG1131	(ABC) transporter
KM399_22780	COG2205	protein histidine kinase activity
KM399_22785	COG0745	RESPONSE REGULATOR receiver
KM399_22795	COG4895	conserved protein (DUF2196)
KM399_22800	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KM399_22815	COG4509	Sortase family
KM399_22820	COG1120	ATPase activity
KM399_22835	COG5386	Cell surface protein
KM399_22845	COG5386	Cell surface protein
KM399_22850	COG1114	Component of the transport system for branched-chain amino acids
KM399_22855	COG1187	pseudouridine synthase activity
KM399_22865	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM399_22865	COG1796	DNA polymerase
KM399_22870	COG1286	toxin biosynthetic process
KM399_22915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM399_22925	COG1418	mRNA catabolic process
KM399_22950	COG2814	Major facilitator Superfamily
KM399_22955	COG1566	PFAM secretion protein HlyD family protein
KM399_22960	COG1309	transcriptional regulator
KM399_22965	COG1363	Peptidase, m42
KM399_22990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM399_23000	COG1484	DNA-dependent DNA replication
KM399_23005	COG3611	Membrane attachment protein
KM399_23015	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM399_23020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM399_23025	COG0237	dephospho-CoA kinase activity
KM399_23030	COG1971	Probably functions as a manganese efflux pump
KM399_23040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM399_23040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM399_23045	COG5002	protein histidine kinase activity
KM399_23050	COG0745	RESPONSE REGULATOR receiver
KM399_23070	COG0538	isocitrate dehydrogenase activity
KM399_23075	COG0372	Belongs to the citrate synthase family
KM399_23085	COG0628	permease
KM399_23090	COG3030	protein affecting phage T7 exclusion by the F plasmid
KM399_23115	COG1725	Transcriptional regulator
KM399_23120	COG0281	malic enzyme
KM399_23125	COG0587	DNA-directed DNA polymerase activity
KM399_23140	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KM399_23160	COG4109	DRTGG domain
KM399_23175	COG0006	proline dipeptidase activity
KM399_23210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM399_23215	COG0662	Cupin 2, conserved barrel domain protein
KM399_23225	COG1476	TRANSCRIPTIONal
KM399_23240	COG1028	Short-chain dehydrogenase reductase Sdr
KM399_23245	COG0589	response to stress
KM399_23285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM399_23305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KM399_23310	COG0827	DNA restriction-modification system
KM399_23315	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KM399_23320	COG3874	Sporulation protein YtfJ
KM399_23335	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KM399_23345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM399_23360	COG1104	cysteine desulfurase activity
KM399_23370	COG0583	DNA-binding transcription factor activity
KM399_23375	COG0697	spore germination
KM399_23385	COG1956	GAF domain-containing protein
KM399_23390	COG0626	cystathionine gamma-synthase activity
KM399_23420	COG1595	DNA-templated transcription, initiation
KM399_23430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM399_23435	COG0454	-acetyltransferase
KM399_23440	COG0517	IMP dehydrogenase activity
KM399_23445	COG0123	including yeast histone deacetylase and acetoin utilization protein
KM399_23455	COG0745	RESPONSE REGULATOR receiver
KM399_23465	COG0666	response to abiotic stimulus
KM399_23500	COG1609	Transcriptional regulator
KM399_23505	COG4851	CamS sex pheromone cAM373 precursor
KM399_23510	COG3118	belongs to the thioredoxin family
KM399_23520	COG2309	aminopeptidase activity
KM399_23540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM399_23555	COG1674	ftsk spoiiie
KM399_23565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM399_23570	COG4848	Belongs to the UPF0354 family
KM399_23575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM399_23580	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
KM399_23585	COG1363	Peptidase, m42
KM399_23595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM399_23610	COG0510	thiamine kinase activity
KM399_23615	COG1523	belongs to the glycosyl hydrolase 13 family
KM399_23630	COG1349	DNA-binding transcription factor activity
KM399_23635	COG1187	pseudouridine synthase activity
KM399_23640	COG2244	polysaccharide biosynthetic process
KM399_23645	COG2081	HI0933 family
KM399_23650	COG2814	Major facilitator Superfamily
KM399_23660	COG3832	glyoxalase III activity
KM399_23680	COG1329	Transcriptional regulator
KM399_23690	COG4975	Glucose uptake
KM399_23705	COG0314	molybdopterin synthase activity
KM399_23710	COG1763	Mo-molybdopterin cofactor biosynthetic process
KM399_23715	COG0303	'Molybdopterin
KM399_23725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM399_23750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM399_23760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM399_23805	COG2814	Major facilitator Superfamily
KM399_23810	COG0475	glutathione-regulated potassium exporter activity
KM399_23815	COG0490	domain, Protein
KM399_23820	COG0582	viral genome integration into host DNA
KM399_23830	COG1136	(ABC) transporter
KM399_23850	COG1242	4 iron, 4 sulfur cluster binding
KM399_23855	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KM399_23860	COG1131	(ABC) transporter
KM399_23870	COG1794	racemase activity, acting on amino acids and derivatives
KM399_23890	COG2267	carboxylic ester hydrolase activity
KM399_23895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KM399_23900	COG0671	phosphoesterase, PA-phosphatase related
KM399_23905	COG0438	transferase activity, transferring glycosyl groups
KM399_23915	COG0521	Mo-molybdopterin cofactor biosynthetic process
KM399_23970	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM399_23975	COG5002	protein histidine kinase activity
KM399_23980	COG4191	Histidine kinase
KM399_23985	COG2267	carboxylic ester hydrolase activity
KM399_24005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM399_24010	COG1116	anion transmembrane transporter activity
KM399_24015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM399_24040	COG0494	nUDIX hydrolase
KM399_24070	COG0288	reversible hydration of carbon dioxide
KM399_24075	COG1271	oxidase subunit
KM399_24080	COG1294	oxidase, subunit
KM399_24100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM399_24125	COG1842	Phage shock protein A
KM399_24155	COG5002	protein histidine kinase activity
KM399_24160	COG0745	RESPONSE REGULATOR receiver
KM399_24190	COG1597	lipid kinase activity
KM399_24225	COG0586	Pfam SNARE associated Golgi protein
KM399_24235	COG0577	efflux transmembrane transporter activity
KM399_24240	COG1136	(ABC) transporter
KM399_24245	COG3708	Transcriptional regulator
KM399_24245	COG2207	Transcriptional regulator
KM399_24250	COG0745	RESPONSE REGULATOR receiver
KM399_24255	COG2205	protein histidine kinase activity
KM399_24260	COG0577	efflux transmembrane transporter activity
KM399_24270	COG0577	efflux transmembrane transporter activity
KM399_24275	COG1136	(ABC) transporter
KM399_24295	COG2188	Transcriptional regulator
KM399_24315	COG3964	amidohydrolase
KM399_24345	COG4948	Mandelate Racemase Muconate Lactonizing
KM399_24355	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KM399_24360	COG0596	Alpha beta hydrolase
KM399_24365	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KM399_24370	COG1169	isochorismate synthase
KM399_24375	COG1575	Belongs to the MenA family. Type 1 subfamily
KM399_24380	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KM399_24400	COG0058	SHG alpha-glucan phosphorylase activity
KM399_24405	COG0297	glycogen (starch) synthase activity
KM399_24410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KM399_24530	COG0544	peptidyl-prolyl cis-trans isomerase activity
KM399_24565	COG1285	pathogenesis
KM399_24570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM399_24580	COG0166	Belongs to the GPI family
KM399_24585	COG2155	Conserved Protein
KM399_24590	COG1098	S1 RNA binding domain
KM399_24595	COG0436	Aminotransferase
KM399_24600	COG1522	sequence-specific DNA binding
KM399_24605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM399_24610	COG2267	carboxylic ester hydrolase activity
KM399_24620	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KM399_24640	COG5018	Exonuclease
KM399_24645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM399_24665	COG2050	protein possibly involved in aromatic compounds catabolism
KM399_24675	COG1268	BioY protein
KM399_24685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM399_24690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KM399_24705	COG3584	3D domain protein
KM399_24720	COG1252	NADH dehydrogenase
KM399_24735	COG3708	Transcriptional regulator
KM399_24750	COG1683	Conserved Protein
KM399_24770	COG0316	Belongs to the HesB IscA family
KM399_24785	COG1252	NADH dehydrogenase
KM399_24800	COG0390	transport system, permease component
KM399_24805	COG2824	Alkylphosphonate utilization operon protein PhnA
KM399_24845	COG4837	Protein of unknown function (DUF1462)
KM399_24850	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KM399_24860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM399_24865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KM399_24875	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM399_24880	COG0647	UMP catabolic process
KM399_24890	COG2445	Protein of unknown function DUF86
KM399_24895	COG1494	fructose-1,6-bisphosphatase
KM399_24910	COG4470	Protein conserved in bacteria
KM399_24920	COG0789	Transcriptional regulator
KM399_24925	COG4377	Putative membrane peptidase family (DUF2324)
KM399_24950	COG0739	heme binding
KM399_24960	COG3377	Domain of unknown function (DUF1805)
KM399_24965	COG0737	Belongs to the 5'-nucleotidase family
KM399_24970	COG1695	Transcriptional regulator
KM399_24980	COG0719	Fe-S assembly protein
KM399_24985	COG0822	iron-sulfur transferase activity
KM399_24990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KM399_24995	COG0719	Fe-S assembly protein
KM399_25000	COG0396	ATPase activity
KM399_25005	COG1464	Belongs to the NlpA lipoprotein family
KM399_25010	COG1464	Belongs to the NlpA lipoprotein family
KM399_25015	COG2011	ABC-type metal ion transport system permease component
KM399_25020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM399_25030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM399_25035	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM399_25045	COG1393	Belongs to the ArsC family
KM399_25090	COG0039	L-malate dehydrogenase activity
KM399_25110	COG1309	transcriptional regulator
KM399_25115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM399_25120	COG1960	acyl-CoA dehydrogenase activity
KM399_25125	COG0183	Belongs to the thiolase family
KM399_25130	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM399_25130	COG1024	Enoyl-CoA hydratase
KM399_25140	COG1686	Belongs to the peptidase S11 family
KM399_25155	COG0011	TIGRFAM Protein of
KM399_25160	COG0840	transmembrane signaling receptor activity
KM399_25180	COG2814	Major facilitator Superfamily
KM399_25185	COG0531	amino acid
KM399_25195	COG0706	membrane insertase activity
KM399_25205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM399_25240	COG0586	Pfam SNARE associated Golgi protein
KM399_25250	COG1376	ErfK ybiS ycfS ynhG family protein
KM399_25255	COG0745	RESPONSE REGULATOR receiver
KM399_25260	COG5002	protein histidine kinase activity
KM399_25285	COG2151	metal-sulfur cluster biosynthetic enzyme
KM399_25290	COG3227	Zinc metalloprotease (Elastase)
KM399_25295	COG1741	Belongs to the pirin family
KM399_25310	COG0475	glutathione-regulated potassium exporter activity
KM399_25315	COG0490	domain, Protein
KM399_25320	COG1115	amino acid carrier protein
KM399_25325	COG0783	Belongs to the Dps family
KM399_25340	COG1611	Belongs to the LOG family
KM399_25360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM399_25365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM399_25370	COG1115	amino acid carrier protein
KM399_25375	COG1115	amino acid carrier protein
KM399_25380	COG2910	NAD(P)H-binding
KM399_25395	COG0656	L-ascorbic acid biosynthetic process
KM399_25400	COG2814	Major facilitator Superfamily
KM399_25405	COG1733	regulation of RNA biosynthetic process
KM399_25415	COG1252	NADH dehydrogenase
KM399_25420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KM399_25425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM399_25435	COG3290	protein histidine kinase activity
KM399_25435	COG0840	transmembrane signaling receptor activity
KM399_25445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM399_25450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM399_25465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM399_25520	COG0557	exoribonuclease II activity
KM399_25525	COG1647	Serine aminopeptidase, S33
KM399_25530	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM399_25535	COG1346	cytolysis
KM399_25630	COG4695	Portal protein
KM399_25655	COG4974	Belongs to the 'phage' integrase family
KM399_25665	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KM399_25670	COG0149	triose-phosphate isomerase activity
KM399_25680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM399_25695	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KM399_25720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM399_25735	COG2323	membrane
KM399_25740	COG0740	serine-type endopeptidase activity
KM399_25745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM399_25755	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KM399_25765	COG1051	belongs to the nudix hydrolase family
KM399_25775	COG0492	ferredoxin-NADP+ reductase activity
KM399_25780	COG0457	Tetratricopeptide repeat
KM399_25785	COG0110	maltose O-acetyltransferase activity
KM399_25805	COG1950	PFAM Membrane protein of
KM399_25815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM399_25820	COG0556	nucleotide-excision repair
KM399_25840	COG0789	Transcriptional regulator
KM399_25865	COG2855	membrane
KM399_25870	COG0583	DNA-binding transcription factor activity
KM399_25880	COG0655	NAD(P)H dehydrogenase (quinone) activity
KM399_25885	COG0488	(ABC) transporter
KM399_25895	COG1132	(ABC) transporter
KM399_25900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM399_25905	COG3409	Peptidoglycan-binding domain 1 protein
KM399_25905	COG0793	Belongs to the peptidase S41A family
KM399_25910	COG2177	Part of the ABC transporter FtsEX involved in
KM399_25915	COG2884	Cell division ATP-binding protein ftsE
KM399_25930	COG0653	protein targeting
KM399_25935	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KM399_25940	COG1278	Cold shock
KM399_25945	COG1040	competence protein
KM399_25950	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KM399_25955	COG1388	LysM domain
KM399_25955	COG0791	NLP P60 protein
KM399_25960	COG1733	regulation of RNA biosynthetic process
KM399_25965	COG1307	EDD domain protein, DegV family
KM399_25970	COG1739	Uncharacterized protein family UPF0029
KM399_25975	COG1316	TRANSCRIPTIONal
KM399_25980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM399_25985	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KM399_25990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KM399_26000	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KM399_26000	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KM399_26015	COG3394	polysaccharide catabolic process
KM399_26020	COG1486	melibiose metabolic process
KM399_26025	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM399_26030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM399_26040	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KM399_26045	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM399_26050	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM399_26060	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM399_26065	COG1301	dicarboxylic acid transport
KM399_26075	COG0346	lactoylglutathione lyase activity
KM399_26080	COG1511	domain protein
KM399_26085	COG0583	DNA-binding transcription factor activity
KM399_26090	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KM399_26105	COG1271	oxidase subunit
KM399_26110	COG1294	oxidase, subunit
KM399_26115	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM399_26135	COG2389	metal-binding protein
KM399_26145	COG1368	sulfuric ester hydrolase activity
KM399_26160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM399_26170	COG1215	transferase activity, transferring glycosyl groups
KM399_26175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM399_26180	COG3584	3D domain protein
KM399_26180	COG1388	LysM domain
KM399_26205	COG4715	Zinc finger, swim domain protein
KM399_26210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM399_26250	COG0577	efflux transmembrane transporter activity
KM399_26255	COG1136	(ABC) transporter
KM399_26290	COG5002	protein histidine kinase activity
KM399_26295	COG0745	RESPONSE REGULATOR receiver
KM399_26300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM399_26315	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM399_26320	COG1134	teichoic acid transport
KM399_26325	COG1682	transport, permease protein
KM399_26330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KM399_26375	COG1609	Transcriptional regulator
KM399_26390	COG0739	heme binding
KM399_26410	COG2385	sporulation resulting in formation of a cellular spore
KM399_26425	COG4836	Membrane
KM399_26430	COG1007	ATP synthesis coupled electron transport
KM399_26435	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM399_26440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM399_26450	COG0839	Belongs to the complex I subunit 6 family
KM399_26465	COG0649	NAD binding
KM399_26470	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM399_26485	COG5001	Diguanylate cyclase
KM399_26485	COG3300	MHYT domain
KM399_26535	COG0356	it plays a direct role in the translocation of protons across the membrane
KM399_26570	COG0698	ribose 5-phosphate isomerase
KM399_26580	COG2190	(PTS) system
KM399_26585	COG2259	Doxx family
KM399_26590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KM399_26605	COG0009	L-threonylcarbamoyladenylate synthase
KM399_26620	COG2890	protein-(glutamine-N5) methyltransferase activity
KM399_26640	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KM399_26645	COG1494	fructose-1,6-bisphosphatase
KM399_26665	COG4821	SIS domain
KM399_26675	COG3343	RNA polymerase activity
KM399_26685	COG1960	acyl-CoA dehydrogenase activity
KM399_26690	COG1960	acyl-CoA dehydrogenase activity
KM399_26695	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM399_26700	COG0183	Belongs to the thiolase family
KM399_26705	COG2181	nitrate reductase activity
KM399_26705	COG0247	lactate metabolic process
KM399_26710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM399_26720	COG5001	Diguanylate cyclase
KM399_26720	COG3300	MHYT domain
KM399_26740	COG2197	response regulator
KM399_26745	COG4585	Histidine kinase
KM399_26750	COG0842	Transport permease protein
KM399_26755	COG1131	(ABC) transporter
KM399_26760	COG0024	Methionine aminopeptidase
KM399_26770	COG2234	aminopeptidase activity
KM399_26790	COG1595	DNA-templated transcription, initiation
KM399_26795	COG0018	arginyl-trna synthetase
KM399_26800	COG4506	Protein conserved in bacteria
KM399_26805	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM399_26820	COG0010	Belongs to the arginase family
KM399_26830	COG2814	Major facilitator Superfamily
KM399_26835	COG0789	Transcriptional regulator
KM399_26840	COG0584	glycerophosphoryl diester phosphodiesterase
KM399_26845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM399_26855	COG1994	Peptidase M50
KM399_26865	COG1078	dGTPase activity
KM399_26870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM399_26875	COG1120	ATPase activity
KM399_26880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM399_26905	COG0095	Lipoate-protein ligase
KM399_26910	COG0280	phosphate acetyltransferase
KM399_26925	COG3773	Cell wall hydrolase
KM399_26935	COG2363	Small membrane protein
KM399_26945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM399_26950	COG2233	PERMEase
KM399_26955	COG0561	phosphatase activity
KM399_26960	COG2814	Major facilitator Superfamily
KM399_26970	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM399_26975	COG1131	(ABC) transporter
KM399_26980	COG2755	lipolytic protein G-D-S-L family
KM399_26985	COG1609	Transcriptional regulator
KM399_26995	COG0460	homoserine dehydrogenase
KM399_27005	COG2873	o-acetylhomoserine
KM399_27015	COG1011	Hydrolase
KM399_27020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM399_27030	COG2197	response regulator
KM399_27040	COG0351	phosphomethylpyrimidine kinase
KM399_27045	COG3706	GGDEF domain
KM399_27050	COG2879	small protein
KM399_27055	COG1966	Carbon starvation protein
KM399_27060	COG3279	Response regulator of the LytR AlgR family
KM399_27065	COG0477	Major facilitator Superfamily
KM399_27090	COG0840	transmembrane signaling receptor activity
KM399_27100	COG1607	acyl-coa hydrolase
KM399_27115	COG0488	(ABC) transporter
KM399_27135	COG0463	Glycosyl transferase, family 2
KM399_27140	COG1309	transcriptional regulator
KM399_27145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM399_27150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM399_27150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM399_27155	COG0628	permease
KM399_27170	COG3279	Response regulator of the LytR AlgR family
KM399_27175	COG3275	phosphorelay sensor kinase activity
KM399_27180	COG2814	Major facilitator Superfamily
KM399_27185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM399_27190	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KM399_27195	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM399_27215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM399_27220	COG1272	protein, Hemolysin III
KM399_27240	COG0516	GMP reductase activity
KM399_27245	COG1164	Oligoendopeptidase f
KM399_27265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM399_27270	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KM399_27275	COG4853	Protein conserved in bacteria
KM399_27280	COG4863	YycH protein
KM399_27285	COG5002	protein histidine kinase activity
KM399_27290	COG0745	RESPONSE REGULATOR receiver
KM399_27320	COG0305	Participates in initiation and elongation during chromosome replication
KM399_27330	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KM399_27335	COG4241	membrane
KM399_27345	COG0629	single-stranded DNA binding
KM399_27355	COG0012	GTP binding
KM399_27360	COG4481	Protein conserved in bacteria
KM399_27365	COG0668	transmembrane transport
KM399_27375	COG1475	DNA binding
KM399_27380	COG1192	Involved in chromosome partitioning
KM399_27405	COG1847	R3H domain protein
KM399_27410	COG0706	membrane insertase activity
KM399_27420	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KM399_27475	COG3344	reverse transcriptase
KM399_27555	COG3344	reverse transcriptase
KM399_27750	COG4962	Type ii secretion system protein e
KM399_27885	COG2311	Membrane
KM399_27905	COG4196	transglutaminase domain protein
KM399_27910	COG0671	phosphoesterase, PA-phosphatase related
KM399_27925	COG1215	transferase activity, transferring glycosyl groups
KM399_27930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM399_27935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KM399_28105	COG2002	toxin-antitoxin pair type II binding
KM399_28115	COG4974	Belongs to the 'phage' integrase family
KM399_28170	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM399_28180	COG4974	Belongs to the 'phage' integrase family
KM399_28205	COG0457	Tetratricopeptide repeat
KM399_28410	COG0791	NLP P60 protein
KM399_28410	COG0741	lytic transglycosylase activity
KM399_28475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM399_28535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM399_28545	COG4166	transmembrane transport
KM399_28585	COG1280	lysine exporter protein (LysE YggA)
KM399_28610	COG0681	Belongs to the peptidase S26 family
KM399_28685	COG1309	transcriptional regulator
KM399_28690	COG1683	Conserved Protein
KM399_28730	COG1192	Involved in chromosome partitioning