locus-tag class description BF39_100 ENOG4105BZU Histidine kinase BF39_1004 ENOG4105C37 (CBS) domain BF39_1009 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF39_1012 ENOG4107S4Y M20 DapE family protein YgeY BF39_1013 ENOG4108TSC N-acetyltransferase BF39_1014 ENOG4108JUB Transcriptional regulator BF39_1015 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BF39_102 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BF39_1023 ENOG4108N23 SpoOM-related protein BF39_1025 ENOG410841Q phosphoesterase PA-phosphatase related protein BF39_1026 ENOG4105SZ6 Thioredoxin BF39_1028 ENOG4108IBT Inherit from COG: transposase BF39_103 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BF39_1047 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF39_1057 ENOG4105CZM Major Facilitator BF39_1058 ENOG4105W8X HesB YadR YfhF-family protein BF39_1060 ENOG4105DXD 2-methylcitrate dehydratase BF39_1061 ENOG4105CR4 methylisocitrate lyase BF39_1062 ENOG4105C1G acyl-Coa dehydrogenase BF39_1063 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF39_1065 ENOG4105N14 lysine exporter protein LysE YggA BF39_1066 ENOG4105E39 Enoyl-CoA hydratase BF39_1069 ENOG4107RFY SbcCD D subunit BF39_1070 ENOG4105EYH Exonuclease BF39_1074 ENOG4105FCD Major Facilitator BF39_1075 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BF39_1076 ENOG4105E4F Isochorismate synthase BF39_1077 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BF39_1078 ENOG4105WQI isochorismatase BF39_1079 ENOG4105CEY Amp-dependent synthetase and ligase BF39_1080 ENOG4105WQT MbtH domain protein BF39_1081 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF39_1084 ENOG4105K70 DNA-binding protein BF39_1088 ENOG4105BZG amino acid carrier protein BF39_1092 ENOG4105FE9 pseudouridine synthase BF39_1093 ENOG4105C22 threonyL-tRNA synthetase BF39_1098 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF39_1104 ENOG4108D32 Methyltransferase BF39_1110 ENOG41081I9 integral membrane protein BF39_1113 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF39_1115 ENOG4105EYF MMPL domain protein BF39_112 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BF39_1120 ENOG4105WCN acetyltransferase BF39_1126 ENOG4105C1Q protoporphyrinogen oxidase BF39_1128 ENOG41068WN BF39_113 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF39_1130 ENOG4105VEQ Cold shock protein BF39_1134 ENOG410667J hydrolase BF39_1142 ENOG4107V2S Transcriptional regulator BF39_1143 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF39_1146 ENOG4105DND Transcriptional regulator BF39_1147 ENOG4108RPX mosc domain containing protein BF39_115 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF39_1150 ENOG4105BZ1 (ABC) transporter BF39_1151 ENOG4105BZ1 (ABC) transporter BF39_1155 ENOG4108JCI Transcriptional regulator BF39_116 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF39_1160 ENOG4108KPJ rna polymerase sigma factor BF39_1165 ENOG4105F32 YngK protein BF39_117 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF39_1170 ENOG4105RD7 BadF BadG BcrA BcrD BF39_1172 ENOG4107STF Involved in phosphonate degradation (By similarity) BF39_1175 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF39_1178 ENOG4105C1J atp-dependent rna helicase BF39_118 ENOG4105CZV ABC transporter BF39_1180 ENOG4108RZE Tetr family transcriptional regulator BF39_1184 ENOG41088CC tellurite resistance protein tehB BF39_1186 ENOG4108I0C methyltransferase BF39_1187 ENOG4107RA9 decarboxylase BF39_1188 ENOG41090HR transcriptional regulator BF39_1196 ENOG4105CIN aminoacyl-histidine dipeptidase BF39_120 ENOG4105CJ1 ABC, transporter BF39_1202 ENOG4107RF6 penicillin-binding protein BF39_1203 ENOG4107RF6 penicillin-binding protein BF39_1204 ENOG4107RF6 penicillin-binding protein BF39_1206 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF39_1207 ENOG4105ETE Transcriptional regulator (LacI family BF39_1208 ENOG4105IE8 Alpha-ketoglutarate permease BF39_1209 ENOG4105CK5 oxidoreductase BF39_1214 ENOG4105D2N Aldolase BF39_1215 ENOG4105DH8 myo-inositol catabolism BF39_1219 ENOG4105CGH 5'-nucleotidase BF39_1220 ENOG4105CGH 5'-nucleotidase BF39_1223 ENOG4105VZ8 Transcriptional regulator BF39_1226 ENOG4108VXD carboxy-peptidase BF39_1231 ENOG41067SE Tetr family transcriptional regulator BF39_1232 ENOG4105C5H ABC transporter BF39_1234 ENOG4105BZU Histidine kinase BF39_1236 ENOG4106ANW SMI1_KNR4 BF39_1237 ENOG4105CEP NADH dehydrogenase BF39_1238 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BF39_1241 ENOG4105CJ1 ABC, transporter BF39_1246 ENOG4105C1G acyl-Coa dehydrogenase BF39_1247 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF39_1248 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BF39_1249 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BF39_1250 ENOG4105E39 Enoyl-CoA hydratase BF39_1251 ENOG4107QX3 carboxylase BF39_1252 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF39_1254 ENOG4105WCN acetyltransferase BF39_1255 ENOG4105DBI uridine monophosphokinase BF39_1258 ENOG4105DZ1 carboxypeptidase BF39_1261 ENOG4105T9C HD domain BF39_1263 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF39_1272 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF39_1272 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF39_1275 ENOG4105FQP Beta-lactamase BF39_1277 ENOG4107Y80 Major Facilitator superfamily BF39_128 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF39_1281 ENOG4105CUV Homoserine Kinase BF39_1287 ENOG4105CPQ Dehydrogenase BF39_129 ENOG4105EA8 2-Nitropropane dioxygenase BF39_1290 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF39_1291 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF39_130 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF39_1312 ENOG4105ETU transcriptional activator (TenA BF39_132 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF39_1335 ENOG410667J hydrolase BF39_1337 ENOG4105BZU Histidine kinase BF39_1338 ENOG4107RF6 penicillin-binding protein BF39_1342 ENOG4108JJB ABC transporter BF39_1345 ENOG4108HGU Histidine kinase BF39_1348 ENOG4105CB2 alcohol dehydrogenase BF39_1349 ENOG4105CJN penicillin-binding protein BF39_1358 ENOG4108V4B ThiJ pfpI BF39_1363 ENOG4107Y80 Major Facilitator superfamily BF39_1367 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF39_137 ENOG4105NQC Flavodoxin BF39_1372 ENOG4107Y9U Membrane BF39_1379 ENOG4105FCD Major Facilitator BF39_1381 ENOG4105E09 nadh pyrophosphatase BF39_1382 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF39_1383 ENOG4108Z4K mutator MutT protein BF39_1390 ENOG4108XI2 Domain of unknown function (DUF1963) BF39_1396 ENOG4108NRW Phospholipase, patatin family BF39_1397 ENOG4105KWG Pfam:DUF1696 BF39_1405 ENOG4105PKS Excinuclease abc c subunit domain protein BF39_1413 ENOG4107VFR oxidoreductase BF39_1418 ENOG4105PAD Hydrolase BF39_1423 ENOG4105DY8 decarboxylase BF39_1426 ENOG4108IUM Glycogen debranching enzyme BF39_1431 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF39_1433 ENOG4105FDR Membrane BF39_144 ENOG4107QMU Mate efflux family protein BF39_1440 ENOG4108V3A UPF0421 protein BF39_1444 ENOG4105MSI germination protein ypeb BF39_1448 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BF39_1449 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BF39_145 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF39_1450 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BF39_1451 ENOG4107Z3H Transcriptional regulator, TetR family BF39_1457 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BF39_1461 ENOG4105E98 transcriptional regulator DeoR family BF39_1465 ENOG41062ES Transcriptional regulator BF39_1470 ENOG4107QKR Dehydrogenase BF39_1472 ENOG4107RUY (E1 component), alpha subunit BF39_1474 ENOG4105E1F short-chain dehydrogenase reductase BF39_1475 ENOG4105RHY Pfam:UPF0157 BF39_1481 ENOG4107SQ8 Glycine betaine BF39_1482 ENOG4108IJ7 Glycine betaine BF39_1487 ENOG4105E66 phosphoriboisomerase A BF39_1488 ENOG41082BV acetyltransferase BF39_1489 ENOG4108M1A Chitin-binding protein BF39_1498 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF39_1504 ENOG4108Z7F N-acetyltransferase BF39_1508 ENOG4105EEM helicase BF39_151 ENOG4105CZN Potassium uptake protein BF39_1512 ENOG4105C9U ATP-dependent DNA helicase RecQ BF39_152 ENOG41063Y9 BF39_1521 ENOG4108M1A Chitin-binding protein BF39_1524 ENOG4105BZG amino acid carrier protein BF39_1525 ENOG4105C26 Dehydrogenase BF39_1526 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF39_1527 ENOG4105CTU Proline racemase BF39_1528 ENOG4105CTU Proline racemase BF39_1529 ENOG41080HI glycine oxidase BF39_153 ENOG4105KBJ sporulation protein ytfj BF39_1536 ENOG4107T5V SNARE associated Golgi BF39_1539 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF39_1540 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BF39_1543 ENOG4105DTQ mandelate racemase muconate lactonizing BF39_1551 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BF39_1552 ENOG4105BZU Histidine kinase BF39_1553 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF39_1560 ENOG4105DPN Oligoendopeptidase f BF39_1563 ENOG4105EPR degv family BF39_1571 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF39_1572 ENOG4106K7D Major facilitator family transporter BF39_1576 ENOG4107BMA Transglycosylase associated protein BF39_1579 ENOG41089UC methyltransferase, type 11 BF39_158 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF39_1586 ENOG4105CHM Aminotransferase BF39_159 ENOG4105C7K acetolactate synthase BF39_1592 ENOG4105DVE abc transporter atp-binding protein BF39_16 ENOG4105C7S Dehydrogenase BF39_160 ENOG4108ZP8 Acetolactate synthase small subunit BF39_1601 ENOG4105C02 permease BF39_1603 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BF39_1604 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BF39_1605 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BF39_161 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF39_1610 ENOG4105E09 nadh pyrophosphatase BF39_1614 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BF39_1624 ENOG4107VC0 DNA alkylation repair enzyme BF39_1626 ENOG4107VMI polysaccharide deacetylase BF39_1628 ENOG4108ZCF integral membrane protein BF39_1629 ENOG4105E0M Sulfatase BF39_163 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BF39_1630 ENOG4105C5H ABC transporter BF39_1632 ENOG4105EYF MMPL domain protein BF39_1633 ENOG4105EYF MMPL domain protein BF39_1634 ENOG41082JN Transcriptional regulator BF39_1638 ENOG4105CIH Imidazole acetol-phosphate transaminase BF39_1639 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BF39_1640 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF39_1648 ENOG41069ER domain protein BF39_1650 ENOG4105EMN RNA polymerase sigma factor BF39_1656 ENOG4105D4B ABC, transporter BF39_1658 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BF39_1660 ENOG4105DKT Transcriptional regulator BF39_1661 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BF39_1664 ENOG41061GT Aldolase BF39_1668 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BF39_1674 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BF39_1675 ENOG4105II7 pyrroline-5-carboxylate reductase BF39_1677 ENOG4107258 Transcriptional regulator BF39_1679 ENOG4105E0Y RtcB Protein BF39_168 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BF39_1680 ENOG4105ECK Fatty Acid Desaturase BF39_1681 ENOG4105G6Z alkaline phosphatase BF39_1683 ENOG4105VMP Transcriptional regulator BF39_1686 ENOG41090T1 Membrane BF39_1688 ENOG4108WCX response regulator BF39_1690 ENOG41068WN BF39_1695 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF39_1700 ENOG4105CKK Glycosyl transferase, family 2 BF39_1705 ENOG4105CKK Glycosyl transferase, family 2 BF39_1707 ENOG4105C8Y Acetylornithine aminotransferase BF39_1716 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF39_1718 ENOG4108TVJ Nitroreductase BF39_1719 ENOG4105FS7 Transcriptional regulator BF39_1726 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF39_1728 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF39_1734 ENOG4108XET gCN5-related N-acetyltransferase BF39_175 ENOG4107RVV histidinol phosphate phosphatase, hisj family BF39_1751 ENOG410635A Membrane BF39_1752 ENOG4105KNA -acetyltransferase BF39_1753 ENOG4108IQI permease BF39_1755 ENOG4105F1N DNA alkylation repair BF39_1763 ENOG4107RF6 penicillin-binding protein BF39_1765 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BF39_1772 ENOG4105P4J Allophanate hydrolase, subunit 1 BF39_1773 ENOG4107258 Transcriptional regulator BF39_1775 ENOG4106N3A copper homeostasis protein cutc BF39_1776 ENOG4108ZRV stage ii sporulation protein p BF39_1777 ENOG4108ZHR arsR family transcriptional regulator BF39_1779 ENOG4105FDT acyl-CoA dehydrogenase BF39_178 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF39_1783 ENOG4105DWD nucleoside recognition domain protein BF39_1789 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF39_179 ENOG4105E0M Sulfatase BF39_18 ENOG4105VZ8 Transcriptional regulator BF39_1804 ENOG4105E2A Dehydrogenase BF39_1807 ENOG4108IJ0 Aspartate ammonia-lyase BF39_1808 ENOG4105HDK L-asparaginase BF39_1809 ENOG4108IMY Transcriptional regulator BF39_181 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BF39_1811 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF39_1812 ENOG4105CUB amino acid BF39_1814 ENOG4105II7 pyrroline-5-carboxylate reductase BF39_1816 ENOG4105C6K Malic enzyme BF39_1818 ENOG4108NHD germination protein BF39_1819 ENOG4108NHD germination protein BF39_1820 ENOG4108Q8B Spore germination protein BF39_1825 ENOG4105CSV Glutaminase BF39_1833 ENOG4105CGH 5'-nucleotidase BF39_1834 ENOG4105CH6 catalase BF39_1836 ENOG4105CHJ isochorismatase hydrolase BF39_1842 ENOG41090MY MarR family Transcriptional regulator BF39_185 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BF39_1850 ENOG4108606 TspO/MBR family BF39_1851 ENOG4105CVP deoxyribo-dipyrimidine photolyase BF39_1854 ENOG4108TWJ NADH dehydrogenase subunit 5 BF39_1855 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BF39_1857 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF39_1858 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BF39_1859 ENOG4105DSE periplasmic solute binding protein BF39_186 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BF39_1860 ENOG4105CC5 ABC transporter BF39_1861 ENOG4105DIK (ABC) transporter BF39_1867 ENOG4105D6J arsenicaL-resistance protein BF39_1868 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BF39_1869 ENOG41085FC arsR family transcriptional regulator BF39_1873 ENOG4105F7F Chaperone BF39_1875 ENOG4105CHR reductase BF39_1876 ENOG4108YXU transcriptional regulator AsnC family BF39_188 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF39_189 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF39_1890 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BF39_1891 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF39_1893 ENOG4105IIP Membrane BF39_1896 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF39_1897 ENOG41062D9 Histidine kinase BF39_190 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF39_1902 ENOG4105K6H D-cysteine desulfhydrase BF39_1908 ENOG4105VZ8 Transcriptional regulator BF39_191 ENOG4105C8J )-transporter BF39_1911 ENOG4108NNI Beta-lactamase domain-containing protein BF39_1912 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BF39_1914 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF39_1915 ENOG4105JQZ Methyltransferase BF39_1918 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF39_1919 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BF39_1922 ENOG4105BZU Histidine kinase BF39_1925 ENOG4108U05 Transcriptional regulator BF39_1926 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BF39_1928 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF39_1929 ENOG4105DJB Major Facilitator Superfamily BF39_1930 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BF39_1931 ENOG4107QR9 Iron-sulfur cluster binding protein BF39_1933 ENOG4106P55 Transcriptional regulator BF39_1935 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF39_1941 ENOG4105TRI Hydrolase BF39_1949 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF39_195 ENOG4105DFD Na H antiporter BF39_1952 ENOG4105C8Q Methyl-accepting chemotaxis BF39_1957 ENOG4107QJQ Mate efflux family protein BF39_1960 ENOG4105MZU cell filamentation protein BF39_1961 ENOG4105EQ0 Major Facilitator superfamily BF39_1962 ENOG4108JGH Tetr family transcriptional regulator BF39_1965 ENOG4105C44 Serine transporter BF39_1966 ENOG4105EJQ L-serine dehydratase BF39_1968 ENOG4108JPW Aminotransferase BF39_1971 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BF39_1973 ENOG4105DVH amino acid BF39_1976 ENOG4108JQ1 Dehydrogenase BF39_1980 ENOG4108AEY RNA polymerase sigma factor BF39_1983 ENOG41082W1 Cupin 2, conserved barrel domain protein BF39_1984 ENOG410874W AraC family transcriptional regulator BF39_1987 ENOG4105HIR S-layer domain protein BF39_199 ENOG4105ENE Histidine kinase BF39_1995 ENOG4108ISG Major Facilitator BF39_1997 ENOG4107MII Sugar-specific transcriptional regulator TrmB BF39_1998 ENOG4105CZM Major Facilitator BF39_200 ENOG4105WH1 Two component transcriptional regulator luxr family BF39_2002 ENOG4105DA5 (ABC) transporter BF39_2003 ENOG41069JR BF39_2005 ENOG4105RXJ BF39_2006 ENOG4105KPY Small multidrug resistance protein BF39_2007 ENOG4105KBX Transcriptional regulator, TetR family BF39_2009 ENOG4105CRW Short chain fatty acid transporter BF39_2011 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF39_2017 ENOG4108JJB ABC transporter BF39_2018 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF39_2023 ENOG4108K8S endonuclease I BF39_2026 ENOG41067QW Transcriptional regulator BF39_2028 ENOG4108Z66 YbaK ebsC protein BF39_2029 ENOG4105CUT histidyl-tRNA synthetase BF39_2032 ENOG4105KVH Transcriptional regulator BF39_2033 ENOG4108RCM Nitroreductase BF39_2037 ENOG4108PSK reductase BF39_2039 ENOG4105CJ1 ABC, transporter BF39_204 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BF39_2051 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BF39_2052 ENOG4105DKQ ROK family BF39_2053 ENOG4106UW1 Major Facilitator superfamily BF39_2054 ENOG4108UW5 maltose o-acetyltransferase BF39_2056 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF39_2058 ENOG4105C31 Tryptophanyl-tRNA synthetase BF39_2059 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF39_2064 ENOG4105DMQ Methyltransferase BF39_2066 ENOG4105EV4 Multidrug resistance protein mdtH BF39_2072 ENOG4105C37 (CBS) domain BF39_2075 ENOG4105DDN Pentapeptide repeat-containing protein BF39_2076 ENOG4105XDF Protein of unknown function (DUF1272) BF39_2077 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BF39_2078 ENOG4105CMG Carbohydrate kinase BF39_2079 ENOG4105C6Z Gluconate BF39_2080 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF39_2083 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF39_2084 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF39_2085 ENOG4105CIS alcohol dehydrogenase BF39_2086 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BF39_2089 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BF39_209 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BF39_2090 ENOG4105D4Y metalloprotease BF39_2094 ENOG4105CV8 reductase BF39_2095 ENOG4105F27 Major Facilitator BF39_2098 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BF39_2099 ENOG4105C44 Serine transporter BF39_2105 ENOG4105KVH Transcriptional regulator BF39_2106 ENOG4108TZY GntR Family Transcriptional Regulator BF39_2107 ENOG4105D9R oxidoreductase BF39_2109 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BF39_2110 ENOG4105KVH Transcriptional regulator BF39_2111 ENOG4105KVH Transcriptional regulator BF39_2118 ENOG4105JAB phenazine biosynthesis protein, phzf family BF39_2120 ENOG4105CHR reductase BF39_2124 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BF39_2125 ENOG4105KVH Transcriptional regulator BF39_2129 ENOG4108ZJ4 polysaccharide deacetylase BF39_213 ENOG4105CJ3 phosphate transporter BF39_2139 ENOG4105KAF membrAne BF39_214 ENOG4107GRR phosphate transport regulator BF39_2144 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BF39_2148 ENOG4107YXZ hydrolase, family 25 BF39_215 ENOG4105BZ4 penicillin-binding protein BF39_2153 ENOG4105ED2 Beta-lactamase BF39_2155 ENOG4105H3G oxidoreductase BF39_2162 ENOG4105CIS alcohol dehydrogenase BF39_2169 ENOG4108TN2 lmbE family BF39_217 ENOG4105BZU Histidine kinase BF39_2171 ENOG4107R3E Citrate transporter BF39_2175 ENOG4108MES Periplasmic binding protein BF39_2177 ENOG4105EHG Permease protein BF39_2178 ENOG4105DQ5 transport system permease protein BF39_2179 ENOG4105NX3 Membrane BF39_218 ENOG4105I3N Conserved Protein BF39_2180 ENOG4107ZY0 Phenazine biosynthesis-like protein BF39_2184 ENOG4107CUJ Protein of unknown function (DUF2690) BF39_2186 ENOG4107V2S Transcriptional regulator BF39_2190 ENOG4105C98 muts2 protein BF39_2192 ENOG4105E5K Alpha-amylase BF39_2193 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BF39_2194 ENOG4105DPN Oligoendopeptidase f BF39_2195 ENOG4108A04 Beta-lactamase BF39_2201 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF39_2205 ENOG41082BM Transcriptional regulator, arsr family BF39_2206 ENOG4105CIS alcohol dehydrogenase BF39_221 ENOG4105BZU Histidine kinase BF39_2212 ENOG4105RHY Pfam:UPF0157 BF39_2214 ENOG4105C09 Bile acid BF39_2215 ENOG4105CQB FAD linked oxidase domain protein BF39_2219 ENOG4108UT6 Transferase hexapeptide repeat containing protein BF39_2221 ENOG4105K64 Glycosyl transferase, family 2 BF39_2222 ENOG4105E39 Enoyl-CoA hydratase BF39_2224 ENOG4105KT7 mgtC SapB transporter BF39_2226 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF39_2227 ENOG41073R8 VanW family BF39_2229 ENOG4108R1P BF39_2233 ENOG4105VEQ Cold shock protein BF39_2237 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BF39_2241 ENOG410904N short-chain dehydrogenase reductase BF39_2243 ENOG4106IQC argininosuccinate lyase BF39_2246 ENOG4108IA2 Sodium pantothenate symporter BF39_2248 ENOG4105C26 Dehydrogenase BF39_2249 ENOG4105CHR reductase BF39_2251 ENOG4105EWU Squalene--hopene cyclase BF39_2253 ENOG4105FR1 rard protein BF39_2254 ENOG410696E Membrane BF39_2257 ENOG4105D1F ATP-binding protein BF39_2259 ENOG4108ZAF Molybdopterin BF39_2260 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF39_2261 ENOG4105D06 uba thif-type nad fad binding protein BF39_2262 ENOG4105TMB Formate nitrite transporter BF39_2264 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF39_2265 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BF39_2267 ENOG4108JB9 formate dehydrogenase BF39_2269 ENOG4105E1K spore germination protein BF39_228 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF39_2281 ENOG4107QJT sodium dicarboxylate symporter BF39_2282 ENOG4108KGH TRANSCRIPTIONal BF39_2284 ENOG4105EMN RNA polymerase sigma factor BF39_2288 ENOG4105CIG ABC transporter BF39_229 ENOG4105DZ1 carboxypeptidase BF39_2290 ENOG4105D9R oxidoreductase BF39_2292 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF39_2293 ENOG4105K4P CoA-binding domain protein BF39_2294 ENOG4105C0H protease BF39_2295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF39_2297 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BF39_2298 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF39_2299 ENOG4105W8X HesB YadR YfhF-family protein BF39_230 ENOG4108JIC nucleoside recognition domain protein BF39_2305 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF39_2306 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF39_2308 ENOG4108JJA ABC, transporter BF39_2309 ENOG4108I0Z Aconitate hydratase BF39_2315 ENOG4105E5W Transporter BF39_2317 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF39_232 ENOG4105FE9 pseudouridine synthase BF39_2321 ENOG4107F3J Amp-dependent synthetase and ligase BF39_2322 ENOG4107ZYJ bioY protein BF39_2323 ENOG4105CEY Amp-dependent synthetase and ligase BF39_2332 ENOG4107AYK membrAne BF39_2334 ENOG4105BZU Histidine kinase BF39_2335 ENOG4105FBA Phospholipase Carboxylesterase BF39_2336 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BF39_2337 ENOG4105CK7 Sodium proline symporter BF39_2338 ENOG4105CBC glutamate synthase BF39_2339 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF39_234 ENOG4107TWT Cytochrome c biogenesis protein BF39_2340 ENOG4108VJ1 Transcriptional regulator (CarD family BF39_2341 ENOG4108903 Formimidoylglutamase BF39_2346 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BF39_235 ENOG4105CRE cytochrome C BF39_2357 ENOG4107QIV Cytochrome c biogenesis protein BF39_2359 ENOG4107RSM transcriptional regulator BF39_236 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF39_2360 ENOG4105VAW lrga family BF39_2361 ENOG41067MG lrgb family BF39_2366 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF39_2369 ENOG4105BZ1 (ABC) transporter BF39_237 ENOG4105BZU Histidine kinase BF39_2370 ENOG4105BZ1 (ABC) transporter BF39_2374 ENOG4105D7V transposase BF39_2377 ENOG4105D5T phosphonate abc transporter BF39_238 ENOG4108WBT adenosyltransferase BF39_2380 ENOG4105CGH 5'-nucleotidase BF39_2382 ENOG4108SVB resolvase BF39_2386 ENOG4105K7K Transcriptional regulator BF39_2394 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BF39_2395 ENOG4105XSJ toxin secretion phage lysis holin BF39_241 ENOG4108SAX Membrane BF39_243 ENOG4105T7X BF39_2435 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BF39_244 ENOG4105C9U ATP-dependent DNA helicase RecQ BF39_245 ENOG4105I7S Abortive infection protein BF39_2456 ENOG4105C5F glutamine synthetase BF39_2457 ENOG4105KV4 Transcriptional regulator BF39_2458 ENOG4105CXI aluminum resistance protein BF39_2459 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF39_2460 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF39_2461 ENOG4105EN6 Membrane BF39_2462 ENOG4106F1P AAA ATPase, central domain protein BF39_2469 ENOG41069ER domain protein BF39_247 ENOG4107RGJ metallophosphoesterase BF39_2470 ENOG4105DM4 PTS System BF39_2471 ENOG4105DE4 1-phosphofructokinase BF39_2472 ENOG4105E98 transcriptional regulator DeoR family BF39_2473 ENOG4107QW4 alcohol dehydrogenase BF39_2474 ENOG4107QW4 alcohol dehydrogenase BF39_2475 ENOG4108SJC Membrane BF39_2478 ENOG4105C85 amino acid BF39_248 ENOG4107X2D transcriptional regulator, merr family BF39_2482 ENOG4105TMB Formate nitrite transporter BF39_2483 ENOG4105K70 DNA-binding protein BF39_2484 ENOG4105C59 p-type ATPase BF39_2485 ENOG410681U heavy metal transport detoxification protein BF39_2486 ENOG4105VPX protein, conserved in bacteria BF39_2488 ENOG4105NIV Esterase BF39_2489 ENOG4105E0A ABC, transporter BF39_249 ENOG4108S6Z Negative regulator of genetic competence BF39_2494 ENOG4105CGK Exodeoxyribonuclease III BF39_2496 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF39_2497 ENOG4105D03 DNA-3-methyladenine glycosylase II BF39_2503 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BF39_2504 ENOG4105BZU Histidine kinase BF39_2507 ENOG41067MG lrgb family BF39_2510 ENOG4107TTQ Alpha beta hydrolase fold BF39_2511 ENOG4107YEI lmbE family BF39_2515 ENOG4105F0V Cell wall hydrolase BF39_2516 ENOG4107R6R udp-galactopyranose mutase BF39_2517 ENOG4105E0M Sulfatase BF39_2518 ENOG410890F Dynamin family BF39_2520 ENOG4107QHE Choloylglycine hydrolase BF39_2525 ENOG4105DA5 (ABC) transporter BF39_2530 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF39_2531 ENOG4105DQU oxidoreductase, subunit beta BF39_2532 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BF39_2533 ENOG4108IGT Dipeptidase BF39_2534 ENOG4105MCT stage V sporulation protein S BF39_2535 ENOG4105D48 metallophosphoesterase BF39_254 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BF39_2540 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BF39_2543 ENOG4105XZV Protein of unknown function (DUF3243) BF39_2544 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BF39_2548 ENOG4105UIB (ABC) transporter BF39_2549 ENOG4105UIB (ABC) transporter BF39_255 ENOG4107RB3 L-asparaginase BF39_2550 ENOG4108JQ9 ABC transporter BF39_2551 ENOG4105DIH basic membrane BF39_2552 ENOG4105FDP GntR family transcriptional regulator BF39_2553 ENOG4107QZI cell division protein FtsK BF39_2555 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BF39_2557 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF39_2559 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF39_2560 ENOG4108S0H Dipicolinic acid synthetase, b subunit BF39_2561 ENOG4105E35 Dipicolinate synthase subunit A BF39_2563 ENOG4105C1V Peptidase, M16 BF39_2567 ENOG4105DTN riboflavin biosynthesis protein ribF BF39_2568 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BF39_2570 ENOG4105W7A Protein of unknown function (DUF503) BF39_2572 ENOG4105VHM ribosomal protein BF39_2573 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BF39_2574 ENOG4105CHV Transcription elongation factor NusA BF39_2576 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF39_2578 ENOG4105DZP Membrane-associated zinc metalloprotease BF39_2579 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF39_2580 ENOG4105KNE Phosphatidate cytidylyltransferase BF39_2581 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BF39_2589 ENOG4108HE4 integrase family BF39_2591 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF39_2593 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BF39_2596 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BF39_2601 ENOG4105VB6 UPF0109 protein BF39_2605 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BF39_2606 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BF39_2609 ENOG4105CHR reductase BF39_2610 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BF39_2613 ENOG4105CB5 ATP-dependent DNA helicase recG BF39_2614 ENOG4105DP4 dak2 domain fusion protein ylov BF39_2615 ENOG4108ZAA Alkaline-shock protein BF39_2617 ENOG4105FJ0 thiamine BF39_2618 ENOG4105DJV ribulose-phosphate 3-epimerase BF39_2619 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BF39_262 ENOG4105S2F BF39_2620 ENOG4105D9P serine threonine protein kinase BF39_2621 ENOG4108ZF3 Phosphatase BF39_2623 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF39_2625 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF39_2626 ENOG4105C25 Primosomal protein n' BF39_2627 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BF39_263 ENOG41065D1 BF39_2631 ENOG4105DSJ YicC domain protein BF39_2633 ENOG4105F23 Fibronectin-binding protein BF39_2634 ENOG4105DC7 peptidase M24 BF39_2645 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BF39_2650 ENOG4105C34 Pseudouridine synthase BF39_2653 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF39_2655 ENOG4105DBK s4 domain protein BF39_2656 ENOG41067XK integral membrane protein BF39_2658 ENOG4105DFA alanine racemase domain protein BF39_2659 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BF39_2660 ENOG4105WR5 sporulation protein, YlmC YmxH family BF39_2662 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF39_2664 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BF39_2665 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BF39_2666 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BF39_2667 ENOG4105D4A Cell wall formation (By similarity) BF39_2668 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF39_2669 ENOG4105CNI cell division protein FtsW BF39_2672 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF39_2673 ENOG4105CJN penicillin-binding protein BF39_2674 ENOG4105CJN penicillin-binding protein BF39_2675 ENOG41068DC Essential cell division protein (By similarity) BF39_2682 ENOG4105KNH Nucleic acid-binding protein BF39_269 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BF39_2692 ENOG4105XSJ toxin secretion phage lysis holin BF39_2709 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF39_2711 ENOG4105CAR Terminase, large subunit BF39_272 ENOG4105XXQ heptaprenyl diphosphate synthase component I BF39_2728 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BF39_2731 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF39_274 ENOG4105EAH synthase BF39_2742 ENOG4108IMY Transcriptional regulator BF39_2750 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BF39_2752 ENOG41063PX domain protein BF39_2753 ENOG4105D78 K07001 NTE family protein BF39_2755 ENOG4105H20 Sporulation integral membrane protein YlbJ BF39_2756 ENOG4106H78 methyltransferase BF39_2761 ENOG4107TB6 phosphoglycerate mutase BF39_2764 ENOG4106UY4 Inherit from COG: Scp-like extracellular BF39_2774 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BF39_2775 ENOG4105CNI cell division protein FtsW BF39_2778 ENOG4108IAB Phoh family BF39_278 ENOG4105CIH Imidazole acetol-phosphate transaminase BF39_2782 ENOG4105QA2 BF39_2783 ENOG4105CI3 gtp-binding protein typa BF39_2785 ENOG4105ECY inositol monophosphatase BF39_2789 ENOG4105CXN decarboxylase BF39_279 ENOG41068YB TPR repeat-containing protein BF39_2798 ENOG4105C7S Dehydrogenase BF39_2799 ENOG4105CPP Dehydrogenase, E1 component BF39_2802 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF39_2803 ENOG4108X4Q Hydrolase BF39_2805 ENOG4105CN5 Metallo-Beta-Lactamase BF39_2806 ENOG4107ZYR domain protein BF39_2813 ENOG4108XRC Protein of unknown function (DUF458) BF39_2815 ENOG4107IN1 Protein of unknown function (DUF1797) BF39_2818 ENOG4105EPM Diguanylate phosphodiesterase BF39_2819 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BF39_282 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BF39_2822 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF39_2824 ENOG4105UIN BF39_283 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BF39_2835 ENOG4108HGU Histidine kinase BF39_2837 ENOG4105CHM Aminotransferase BF39_2838 ENOG4105FKQ transcriptional regulator BF39_2839 ENOG4105EG2 ABC transporter, permease BF39_284 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BF39_2841 ENOG4107FKK extracellular solute-binding protein family 1 BF39_2843 ENOG4105CG3 alpha amylase, catalytic region BF39_2852 ENOG4105CHU acetyl-coa acetyltransferase BF39_2859 ENOG4105K7K Transcriptional regulator BF39_2860 ENOG4105DTD Dehydrogenase BF39_2862 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BF39_2864 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BF39_2869 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BF39_2872 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF39_2873 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF39_2874 ENOG4106TD9 Diguanylate cyclase BF39_2878 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BF39_2881 ENOG4105CID antiterminator BF39_2883 ENOG4105FDP GntR family transcriptional regulator BF39_2885 ENOG4105CE4 GlcNAc 6-P deacetylase BF39_2892 ENOG4107ZE5 PPIases accelerate the folding of proteins BF39_2893 ENOG4105PTM secreted protein BF39_2894 ENOG4105J7I hydrolase BF39_2896 ENOG4105G6R Stage v sporulation protein ae BF39_2898 ENOG4105CZ3 stage V sporulation protein ad BF39_2899 ENOG41090VF Stage v sporulation protein ac BF39_29 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BF39_290 ENOG4108JYZ YitT family BF39_2903 ENOG4105C8J )-transporter BF39_2904 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF39_2906 ENOG41082AN stage II sporulation protein BF39_2907 ENOG4105DZ1 carboxypeptidase BF39_2908 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF39_2909 ENOG4105DVE abc transporter atp-binding protein BF39_291 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BF39_2915 ENOG4105D7N magnesium and cobalt transport protein CorA BF39_2920 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF39_2922 ENOG4105I3K Ferric uptake regulator, Fur family BF39_2923 ENOG4105MZ9 stage II sporulation protein m BF39_2927 ENOG4105CPC Aldo Keto reductase BF39_2929 ENOG4105RHY Pfam:UPF0157 BF39_2933 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF39_2935 ENOG4105ETE Transcriptional regulator (LacI family BF39_2936 ENOG4108YM7 Gcn5-related n-acetyltransferase BF39_294 ENOG4105FJR Lmbe family BF39_2940 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BF39_2941 ENOG4108R6K riboflavin synthase, subunit alpha BF39_2945 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BF39_2946 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF39_2947 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF39_2948 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BF39_295 ENOG4105CPK Glycosyl transferase (Group 1 BF39_2950 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF39_2952 ENOG4105DFD Na H antiporter BF39_2953 ENOG4105CGH 5'-nucleotidase BF39_2961 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BF39_2964 ENOG4108IXY short-chain dehydrogenase reductase BF39_2965 ENOG41069FQ Metallo-beta-lactamase superfamily BF39_2967 ENOG4105II7 pyrroline-5-carboxylate reductase BF39_2968 ENOG4105EJQ L-serine dehydratase BF39_2972 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF39_2974 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF39_2975 ENOG4105D9U N-acetyltransferase BF39_2977 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BF39_2978 ENOG4108QEG Membrane BF39_2979 ENOG4105CDA abc transporter atp-binding protein BF39_2980 ENOG4105E5Q amino acid AbC transporter BF39_2981 ENOG4108HW3 (ABC) transporter BF39_2983 ENOG4105G7B Protein of unknown function (DUF2992) BF39_2984 ENOG4105E09 nadh pyrophosphatase BF39_2986 ENOG4105C7S Dehydrogenase BF39_2987 ENOG4105CPP Dehydrogenase, E1 component BF39_2991 ENOG4107RDP Dehydrogenase BF39_2993 ENOG4108JUB Transcriptional regulator BF39_2995 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF39_2998 ENOG4107QQR Sporulation BF39_2999 ENOG4105S1Z Stage IV sporulation protein B BF39_3000 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BF39_3002 ENOG4105DX0 Hemolysin A BF39_3004 ENOG4105CTB Polyprenyl synthetase BF39_3009 ENOG4108ZSR alkaline shock protein BF39_3010 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF39_3015 ENOG410644B Stage III sporulation protein af BF39_3017 ENOG4105KQ4 Stage iii sporulation protein ad BF39_3018 ENOG4108CQH stage III sporulation protein AC BF39_3019 ENOG4105KR5 Stage iii sporulation protein BF39_302 ENOG4105DVT helicase BF39_3020 ENOG4105CD2 stage iii sporulation protein aa BF39_3025 ENOG4105DC7 peptidase M24 BF39_3028 ENOG4105CBJ Metal-dependent enzyme BF39_3029 ENOG4107YBY Hydrolase BF39_303 ENOG4105YAC BF39_3034 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BF39_3035 ENOG4105WZW rhodanese family BF39_3039 ENOG41080TC multidrug resistance protein BF39_3046 ENOG4105CJ1 ABC, transporter BF39_3047 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF39_3053 ENOG4105C0D helicase BF39_307 ENOG4105CSM endonuclease III BF39_3077 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF39_3078 ENOG4105C3R Methionine synthase BF39_3080 ENOG4105C28 cystathionine BF39_3081 ENOG4105C28 cystathionine BF39_3085 ENOG4105C5X domain protein BF39_3087 ENOG4105DKQ ROK family BF39_3089 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BF39_309 ENOG4105BZ4 penicillin-binding protein BF39_3093 ENOG4108UTW Plays a role in the regulation of phosphate uptake BF39_3094 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BF39_3095 ENOG4105E2Z phosphate ABC transporter (Permease BF39_3096 ENOG4105C8U phosphate abc transporter BF39_3097 ENOG4105PWN phosphate abc transporter BF39_3098 ENOG4107RF6 penicillin-binding protein BF39_31 ENOG4105DZ1 carboxypeptidase BF39_3100 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF39_3105 ENOG4105N80 Ferric uptake regulator, Fur family BF39_3107 ENOG4105FDK ABC transporter BF39_3108 ENOG4108JYZ YitT family BF39_3109 ENOG41069ZM Protein of unknown function (DUF2624) BF39_3114 ENOG4105EGD dinuclear metal center protein, YbgI family BF39_3117 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF39_3118 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BF39_3123 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BF39_3124 ENOG4105KG3 cytidine deaminase BF39_3125 ENOG4107YR5 Diacylglycerol kinase BF39_3127 ENOG4105CTJ Metal Dependent Phosphohydrolase BF39_3128 ENOG4105C9A Phoh family BF39_3130 ENOG41068P3 sporulation protein YqfC BF39_3131 ENOG4105KTH gatB Yqey BF39_3133 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF39_3134 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BF39_3138 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BF39_3140 ENOG4105CSA Coproporphyrinogen iii oxidase BF39_3141 ENOG4105KVH Transcriptional regulator BF39_3146 ENOG4105TQK DNA polymerase iii, delta' subunit BF39_3148 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF39_3149 ENOG4108UK2 deaminase BF39_3150 ENOG4105KQC Competence protein BF39_3152 ENOG4105DXX methyltransferase BF39_3154 ENOG4108WF2 Metal Dependent Phosphohydrolase BF39_3156 ENOG410812S Rna-binding protein BF39_3158 ENOG4105CQW ribosome biogenesis GTPase YqeH BF39_3159 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF39_3162 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF39_3167 ENOG4108TVJ Nitroreductase BF39_3170 ENOG4105G6Z alkaline phosphatase BF39_3172 ENOG4108MUZ hydrolase BF39_3179 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF39_3180 ENOG4105MIR Phenylalanine 4-monooxygenase BF39_3182 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF39_3183 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF39_3191 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF39_3192 ENOG4108V5C ABC transporter BF39_3194 ENOG4108EKI Dehydrogenase BF39_3195 ENOG4105C28 cystathionine BF39_32 ENOG4105VFR signal peptidase BF39_320 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BF39_3201 ENOG4107XRG penicillin-binding protein BF39_3204 ENOG4105CFP Peptidase U32 BF39_3205 ENOG4105XYU peptidase (U32 family) BF39_3206 ENOG4108VQJ O-methyltransferase BF39_3207 ENOG4105HHA aminodeoxychorismate lyase BF39_3211 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF39_3213 ENOG4105C02 permease BF39_3216 ENOG41060CR BF39_3217 ENOG4105C7H Helicase, RecD TraA family BF39_3219 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BF39_322 ENOG4105DVT helicase BF39_3220 ENOG4105C3J Cysteine desulfurase BF39_3222 ENOG4105D1H recombination factor protein RarA BF39_3223 ENOG4108VCI transcription factor, rsfa family BF39_3224 ENOG4105CUZ uba thif-type nad fad binding protein BF39_3226 ENOG4105CUT histidyl-tRNA synthetase BF39_3229 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF39_323 ENOG4105CTD carboxy-peptidase BF39_3231 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF39_3232 ENOG41076HS cation diffusion facilitator family transporter BF39_3233 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BF39_3235 ENOG4105CKP Polysaccharide Biosynthesis Protein BF39_3236 ENOG4108QG2 Membrane BF39_3238 ENOG4105VIE preprotein translocase, subunit YajC BF39_3241 ENOG41061AI Protein of unknown function (DUF2905) BF39_3244 ENOG4108HUF Transporter BF39_3246 ENOG4108IPJ Membrane BF39_3247 ENOG4108IPJ Membrane BF39_3248 ENOG41082BM Transcriptional regulator, arsr family BF39_3253 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BF39_3254 ENOG4108IYU L-aspartate oxidase BF39_3257 ENOG4108RPX mosc domain containing protein BF39_3258 ENOG4105CQC Prephenate dehydratase BF39_326 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF39_3262 ENOG4105EWM Histidine kinase BF39_3265 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BF39_3268 ENOG4105X36 (ribosomal) protein BF39_3270 ENOG4105C03 ribonuclease BF39_3273 ENOG4107QMS site-determining protein BF39_3276 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BF39_3277 ENOG4105DFF Rod shape-determining protein mreb BF39_328 ENOG4105C2W permease BF39_3281 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BF39_3282 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BF39_3284 ENOG41068KH stage VI sporulation protein D BF39_3286 ENOG4105D52 delta-aminolevulinic acid dehydratase BF39_329 ENOG4105DHF Membrane BF39_3291 ENOG4105K56 Transcriptional regulator BF39_3295 ENOG4108IUQ atp-dependent protease BF39_3301 ENOG4108QCI YvbH-like oligomerisation region BF39_3305 ENOG4105M59 Phosphodiesterase, mj0936 family BF39_3306 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BF39_3308 ENOG4108XJQ germination protein BF39_331 ENOG410890F Dynamin family BF39_3310 ENOG4108PCX Major Facilitator BF39_3312 ENOG4105KBX Transcriptional regulator, TetR family BF39_3315 ENOG4105PFC Transcriptional regulator BF39_3318 ENOG4105DZC cytosine deaminase BF39_3319 ENOG4105DZC cytosine deaminase BF39_3320 ENOG4105DEF Extracellular solute-binding protein, family 5 BF39_3321 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF39_3324 ENOG4108JQ7 (ABC) transporter BF39_3325 ENOG4108HRK Histidine kinase BF39_3326 ENOG4105DY9 regulatoR BF39_3329 ENOG41067S9 phage shock protein C, PspC BF39_333 ENOG4108W0I acetyltransferase BF39_3330 ENOG4108JCI Transcriptional regulator BF39_3332 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BF39_3333 ENOG4108Z40 Transcriptional regulator BF39_3334 ENOG4105RHA ABC transporter, permease BF39_3335 ENOG4108IUX (ABC) transporter BF39_3336 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BF39_3337 ENOG4105ER2 Ompa motb domain protein BF39_3338 ENOG4105ER2 Ompa motb domain protein BF39_3339 ENOG4105E14 MotA TolQ exbB proton channel BF39_3340 ENOG4108VXD carboxy-peptidase BF39_3342 ENOG4105E33 succinate dehydrogenase BF39_3344 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BF39_3347 ENOG4105K63 Thioredoxin BF39_3348 ENOG4105C10 Electron transfer flavoprotein BF39_3349 ENOG4105BZJ Electron transfer flavoprotein BF39_335 ENOG4105KHC sulfurtransferase BF39_3350 ENOG41060WC Enoyl-CoA hydratase BF39_3351 ENOG4107Z3H Transcriptional regulator, TetR family BF39_3352 ENOG4105CEY Amp-dependent synthetase and ligase BF39_3354 ENOG4105J76 Periplasmic binding protein BF39_3355 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF39_3364 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF39_3367 ENOG4105DR4 Methyltransferase BF39_3370 ENOG4105KFN sortase, SrtB family BF39_3371 ENOG4105E0A ABC, transporter BF39_3374 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BF39_3376 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BF39_3378 ENOG4105FE9 pseudouridine synthase BF39_338 ENOG4106032 Glutathionylspermidine synthase BF39_3381 ENOG4105DCG PHP domain protein BF39_3388 ENOG4105C5S asparaginyl-tRNA synthetase BF39_3389 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BF39_3391 ENOG4108RWN rrna methyltransferase BF39_3398 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF39_3399 ENOG4105CW7 secretion protein, HlyD family BF39_3400 ENOG4108JGH Tetr family transcriptional regulator BF39_3401 ENOG4105CN9 Peptidase m42 family protein BF39_3405 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BF39_3406 ENOG4105C22 threonyL-tRNA synthetase BF39_3407 ENOG4108TDW sporulation protein YtxC BF39_3411 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF39_3412 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BF39_3413 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BF39_3415 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BF39_3416 ENOG4105C2M dna polymerase I BF39_3417 ENOG4105BZU Histidine kinase BF39_3418 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF39_3422 ENOG4108HMX isocitrate dehydrogenase (NADP) BF39_3423 ENOG4105BZN citrate synthase BF39_3425 ENOG4108REF Sporulation integral membrane protein ytvi BF39_3426 ENOG4105FS0 cytoplasmic membrane protein BF39_3431 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF39_3432 ENOG4105C6K Malic enzyme BF39_3433 ENOG4105C0B DNA polymerase III (alpha subunit) BF39_3434 ENOG4105VV2 BF39_3436 ENOG4105SFS phosphoesterase RecJ domain protein BF39_3443 ENOG4105DC7 peptidase M24 BF39_3450 ENOG4105Z7P Acetyltransferase (GNAT) family BF39_3451 ENOG41082W1 Cupin 2, conserved barrel domain protein BF39_3453 ENOG4105VZ8 Transcriptional regulator BF39_3457 ENOG4107YZX Universal stress protein BF39_3466 ENOG4108JYZ YitT family BF39_3470 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BF39_3472 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BF39_3473 ENOG4105KBJ sporulation protein ytfj BF39_3476 ENOG4105EFZ amidohydrolase BF39_3478 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF39_3483 ENOG4106KR7 LysR family Transcriptional regulator BF39_3485 ENOG4105U5Y Transcriptional regulator BF39_3486 ENOG4105U5Y Transcriptional regulator BF39_3488 ENOG4105C28 cystathionine BF39_3492 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF39_3494 ENOG4105EMN RNA polymerase sigma factor BF39_3497 ENOG4105F1V Acetoin utilization protein BF39_3498 ENOG4105W87 Cbs domain BF39_3499 ENOG4105DGU Histone deacetylase BF39_3501 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF39_3503 ENOG4107SNB ankyrin repeat protein YahD BF39_3504 ENOG4105EP9 oxidoreductase BF39_3510 ENOG4105ETE Transcriptional regulator (LacI family BF39_3514 ENOG4105C88 aminopeptidase BF39_352 ENOG4105CPK Glycosyl transferase (Group 1 BF39_3524 ENOG4108VDD TRNA binding domain protein BF39_3530 ENOG4105C8F Beta-lactamase domain protein BF39_3533 ENOG4108V15 phosphotransferase enzyme family BF39_3534 ENOG4108IUM Glycogen debranching enzyme BF39_3536 ENOG4107QSE Dipeptidase BF39_3537 ENOG4107QSE Dipeptidase BF39_3538 ENOG4105YW5 deoR family transcriptional regulator BF39_3541 ENOG4105CBX hi0933 family BF39_3548 ENOG4108VJ1 Transcriptional regulator (CarD family BF39_3549 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BF39_355 ENOG4108SZE gCN5-related N-acetyltransferase BF39_3550 ENOG4105CSC Glucose uptake protein BF39_3553 ENOG4108ZAF Molybdopterin BF39_3554 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BF39_3555 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF39_3557 ENOG4105D06 uba thif-type nad fad binding protein BF39_3558 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF39_3562 ENOG41085GJ domain protein BF39_3564 ENOG4105DWV Homoserine O-trans-acetylase BF39_3566 ENOG4108B31 Spore germination protein BF39_3572 ENOG410605W Major Facilitator BF39_3573 ENOG4107S91 Sodium hydrogen exchanger BF39_3574 ENOG4105NCW Trka-c domain protein BF39_3577 ENOG4105C19 ABC transporter BF39_3581 ENOG4105N5T Radical SAM Protein BF39_3583 ENOG4105DA5 (ABC) transporter BF39_3589 ENOG4105E8V Alpha Beta Hydrolase Fold protein BF39_359 ENOG41081VK Ribonuclease BF39_3590 ENOG4108Z0R Transferase BF39_3591 ENOG4105YVM Phosphoesterase, PA-phosphatase related BF39_3592 ENOG4105BZF Glycosyl transferase (Group 1 BF39_3594 ENOG4108RIR Molybdenum cofactor biosynthesis protein BF39_3604 ENOG4105EGD dinuclear metal center protein, YbgI family BF39_3605 ENOG4105BZU Histidine kinase BF39_3606 ENOG4105BZU Histidine kinase BF39_3607 ENOG4107S9D Alpha beta hydrolase BF39_3608 ENOG4107T7U Sulfatase BF39_3612 ENOG4105D2X ABC transporter substrate-binding protein BF39_3614 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BF39_3618 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF39_3625 ENOG4108V2W Carbonate dehydratase BF39_3627 ENOG4105C4M (Ubiquinol oxidase) subunit I BF39_3628 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF39_3637 ENOG41087YS Phage shock protein A BF39_3644 ENOG4105BZU Histidine kinase BF39_3645 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF39_3650 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF39_3651 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BF39_3658 ENOG4107ZTW SNARE associated Golgi BF39_3661 ENOG4105C19 ABC transporter BF39_3662 ENOG41086D8 Transcriptional regulator BF39_3672 ENOG4105C6Z Gluconate BF39_3673 ENOG4105FDP GntR family transcriptional regulator BF39_3677 ENOG41069H0 dihydroorotase EC 3.5.2.3 BF39_3683 ENOG4105DTQ mandelate racemase muconate lactonizing BF39_3685 ENOG4108IPT Naphthoate synthase BF39_3686 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BF39_3687 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BF39_3688 ENOG4105E4F Isochorismate synthase BF39_3689 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF39_3691 ENOG4105VEQ Cold shock protein BF39_3696 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BF39_3698 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BF39_3701 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF39_372 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF39_3720 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BF39_3728 ENOG4105KT7 mgtC SapB transporter BF39_3730 ENOG4107PBV potassium channel BF39_3731 ENOG4107QYV phosphohexose isomerase BF39_3732 ENOG4105WG9 Conserved Protein BF39_3734 ENOG4105CHM Aminotransferase BF39_3735 ENOG4108ZB6 transcriptional regulator AsnC family BF39_3736 ENOG4105C5I Dehydrogenase BF39_3737 ENOG4108MUZ hydrolase BF39_3739 ENOG4105C87 Aminotransferase class I and II BF39_374 ENOG4107RWR Sodium hydrogen exchanger BF39_3742 ENOG4105Y38 Kinase-associated protein B BF39_3744 ENOG4107R3E Citrate transporter BF39_3747 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BF39_3748 ENOG4105KA0 thioesterase Superfamily protein BF39_375 ENOG4105CN5 Metallo-Beta-Lactamase BF39_3752 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF39_3756 ENOG41069ER domain protein BF39_3759 ENOG4105CEP NADH dehydrogenase BF39_376 ENOG4108Z5V transcriptional regulator, merr family BF39_3765 ENOG4105EWC Purine nucleoside phosphorylase BF39_3768 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BF39_3772 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF39_3773 ENOG4105C4B ABC transporter, permease BF39_3774 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BF39_378 ENOG4105H67 Protein of unknown function (DUF421) BF39_3783 ENOG41083MR nifu domain-containing protein BF39_3786 ENOG4108W5N phosphatidylglycerophosphatase a BF39_3788 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF39_3789 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF39_379 ENOG41080C8 DUF218 domain BF39_3792 ENOG4105CBT Fructose-1,6-bisphosphatase BF39_3795 ENOG4105MMD transcriptional regulator BF39_3796 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BF39_3797 ENOG4107TXC Transcriptional regulator BF39_3798 ENOG41090T1 Membrane BF39_38 ENOG4105C26 Dehydrogenase BF39_3803 ENOG4105FAA peptidase M23 BF39_3805 ENOG4105KZD Domain of unknown function (DUF1805) BF39_3806 ENOG4107R8B 5'-nucleotidase BF39_3809 ENOG4105DIW FeS assembly protein SUFB BF39_3810 ENOG4108UNV SUF system FeS assembly protein, NifU family BF39_3811 ENOG4105C9B Cysteine desulfurase BF39_3812 ENOG4105JRK feS assembly protein SufD BF39_3813 ENOG4105C3K feS assembly ATPase SufC BF39_3814 ENOG4105D01 (LipO)protein BF39_3815 ENOG4105D01 (LipO)protein BF39_3816 ENOG4108UMI ABC transporter, permease BF39_3822 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF39_3831 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF39_3837 ENOG4108W8B Beta-lactamase domain protein BF39_3838 ENOG4105C1G acyl-Coa dehydrogenase BF39_3839 ENOG4105CHU acetyl-coa acetyltransferase BF39_3842 ENOG4105DZ1 carboxypeptidase BF39_3846 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF39_3850 ENOG4108SUT Major Facilitator Superfamily BF39_3851 ENOG4107R7I amino acid BF39_3853 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF39_3855 ENOG4107AYK membrAne BF39_3862 ENOG4107ZTW SNARE associated Golgi BF39_3864 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF39_3865 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF39_3866 ENOG4105BZU Histidine kinase BF39_3868 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BF39_3871 ENOG4105VG1 fes assembly suf system protein BF39_3872 ENOG4105D4Y metalloprotease BF39_3876 ENOG4107S91 Sodium hydrogen exchanger BF39_3877 ENOG4105NCW Trka-c domain protein BF39_3879 ENOG4108RMU ferritin dps family protein BF39_3882 ENOG4108URH decarboxylase BF39_3887 ENOG4105D9N nucleoside BF39_3888 ENOG4105D9N nucleoside BF39_3891 ENOG4108RYK Nad-dependent epimerase dehydratase BF39_3896 ENOG4105CV8 reductase BF39_3897 ENOG4105F27 Major Facilitator BF39_3898 ENOG4105KVH Transcriptional regulator BF39_39 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF39_390 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF39_3901 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF39_3902 ENOG4105D4A Cell wall formation (By similarity) BF39_3904 ENOG4105C8Q Methyl-accepting chemotaxis BF39_3906 ENOG4105WMR Protein CrcB homolog BF39_3907 ENOG4105WMR Protein CrcB homolog BF39_3910 ENOG4108MK9 spermidine N(1)-acetyltransferase BF39_3911 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BF39_3914 ENOG4108IPW abc transporter atp-binding protein BF39_3915 ENOG4105CM4 permease protein BF39_392 ENOG4107R0U MotA TolQ exbB proton channel BF39_3920 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BF39_3922 ENOG4105XZU Preprotein translocase, subunit SecG BF39_3923 ENOG41067MG lrgb family BF39_393 ENOG4105ER2 Ompa motb domain protein BF39_394 ENOG4107YTP response regulator receiver protein BF39_3942 ENOG4105EFC phage portal protein HK97 family BF39_3947 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF39_3949 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BF39_395 ENOG4105CBS Chea signal transduction histidine kinase BF39_3950 ENOG4105CP7 Triose-phosphate isomerase BF39_3955 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF39_3959 ENOG41090VF Stage v sporulation protein ac BF39_396 ENOG4105CBS Chea signal transduction histidine kinase BF39_3960 ENOG4105CZ3 stage V sporulation protein ad BF39_3963 ENOG4105H67 Protein of unknown function (DUF421) BF39_3964 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF39_3965 ENOG4105KRI phosphocarrier protein (HPr BF39_3967 ENOG4105CHW UPF0052 protein BF39_3969 ENOG4108Z4K mutator MutT protein BF39_397 ENOG4105DD5 Flagellar motor switch protein BF39_3971 ENOG4105C3M thioredoxin reductase BF39_3973 ENOG4108S4C acetyltransferase BF39_3977 ENOG41086DT Membrane protein of unknown function BF39_3979 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF39_3980 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BF39_3981 ENOG4105D7V transposase BF39_3984 ENOG4107TXC Transcriptional regulator BF39_3988 ENOG4105HMI Membrane BF39_3989 ENOG4105DUM transcriptional regulator, lysR family BF39_3991 ENOG4108WS4 fmn reductase BF39_3994 ENOG4105BZ1 (ABC) transporter BF39_3996 ENOG4105CN1 protease BF39_3997 ENOG4105CRP Part of the ABC transporter FtsEX involved in BF39_3998 ENOG4105CAK Cell division ATP-binding protein ftsE BF39_40 ENOG4105F38 ABC transporter, permease BF39_400 ENOG4105BZU Histidine kinase BF39_4000 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BF39_4001 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BF39_4002 ENOG4105MS2 ribosomal subunit Interface protein BF39_4003 ENOG4105VEQ Cold shock protein BF39_4004 ENOG41081UC Inherit from COG: Competence protein BF39_4007 ENOG4105KVH Transcriptional regulator BF39_4009 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BF39_4010 ENOG4108KGH TRANSCRIPTIONal BF39_4011 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF39_4012 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF39_4013 ENOG4105ESV Glycosyl transferase, family 4 BF39_4015 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BF39_4018 ENOG410901P UPF0249 protein BF39_4019 ENOG4105F8D glycoside hydrolase family 4 BF39_4020 ENOG4105VCP PTS System BF39_4021 ENOG4105CK1 PTS System BF39_4023 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BF39_4024 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF39_4025 ENOG4105VCP PTS System BF39_4027 ENOG4105VZJ PTS System BF39_4030 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BF39_4031 ENOG4105ECB domain protein BF39_4032 ENOG4107RSM transcriptional regulator BF39_4040 ENOG4105DAA L-lactate BF39_4042 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BF39_4044 ENOG4105E0M Sulfatase BF39_4050 ENOG4107R8N Glycosyl transferase, family 2 BF39_4052 ENOG4105C94 Transporter BF39_4053 ENOG41069ER domain protein BF39_4058 ENOG4105KBK Zinc finger, swim domain protein BF39_4059 ENOG4105C0D helicase BF39_406 ENOG4105DTJ flagellar hook-associated protein BF39_4065 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF39_4067 ENOG4107RBB ABC transporter, permease BF39_4068 ENOG4105C19 ABC transporter BF39_4072 ENOG4105CXY transporter BF39_4075 ENOG4105BZU Histidine kinase BF39_4076 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF39_4077 ENOG4105CMR udp-glucose 4-epimerase BF39_4080 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF39_4081 ENOG4105EY8 ABC transporter BF39_4091 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BF39_4093 ENOG4105FRN stage II sporulation protein BF39_4096 ENOG4105DY9 regulatoR BF39_4097 ENOG4108IUW ABC transporter BF39_41 ENOG4105D38 putrescine abc transporter BF39_4101 ENOG4106778 Protein of unknown function (DUF1146) BF39_4102 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF39_4103 ENOG4105C8S subunit m BF39_4104 ENOG4105D65 subunit l BF39_4109 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF39_411 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BF39_4110 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF39_4112 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF39_4113 ENOG4105BZU Histidine kinase BF39_412 ENOG4108ZC9 flagellar basal-body rod protein flgc BF39_4123 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BF39_4124 ENOG41062M3 atp synthase BF39_4129 ENOG4108YZG isomerase BF39_413 ENOG41075Z6 flagellar hook-basal body complex protein fliE BF39_4132 ENOG4108VGI doxx family BF39_4133 ENOG4107XC4 flavin reductase domain protein, FMN-binding BF39_4136 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF39_4138 ENOG4108ZXQ stage ii sporulation protein r BF39_4139 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF39_414 ENOG4107U2N Flagellar M-ring protein BF39_4140 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BF39_4143 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BF39_4144 ENOG4105CBT Fructose-1,6-bisphosphatase BF39_4145 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BF39_4152 ENOG4105C1G acyl-Coa dehydrogenase BF39_4153 ENOG4105C1G acyl-Coa dehydrogenase BF39_4154 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF39_4156 ENOG4105DF6 Fe-S oxidoreductase BF39_4159 ENOG4105BZU Histidine kinase BF39_416 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF39_4164 ENOG4105BZU Histidine kinase BF39_4165 ENOG4105KCT ABC transporter BF39_4166 ENOG4108M15 ABC transporter BF39_4167 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BF39_4171 ENOG4105IIU Aminopeptidase BF39_4175 ENOG4105EMN RNA polymerase sigma factor BF39_4177 ENOG410684U Domain of unknown function (DUF1934) BF39_4181 ENOG4105CYW agmatinase BF39_4183 ENOG4105DXB Major Facilitator superfamily BF39_4184 ENOG4107SWG transcriptional regulator MERR family BF39_4185 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF39_4186 ENOG4105BZ4 penicillin-binding protein BF39_4187 ENOG4108XFG YwhD family BF39_4188 ENOG4108Z4T Peptidase M50 BF39_4189 ENOG41069HH 4-oxalocrotonate tautomerase BF39_4190 ENOG4105DCI Phosphohydrolase BF39_4191 ENOG4108MES Periplasmic binding protein BF39_4192 ENOG4105E0A ABC, transporter BF39_4193 ENOG4105EHG Permease protein BF39_4194 ENOG4105DQ5 transport system permease protein BF39_4195 ENOG4105DQ5 transport system permease protein BF39_4197 ENOG4108VCI transcription factor, rsfa family BF39_42 ENOG4107RUE extracellular solute-binding protein family 1 BF39_4200 ENOG4108IJ2 phosphate acetyltransferase BF39_4203 ENOG4108VKI Cell wall hydrolase BF39_4207 ENOG4107SVH Potassium channel protein BF39_4209 ENOG410667J hydrolase BF39_4210 ENOG4105VCH membrane BF39_4212 ENOG4108TU7 Inherit from COG: (ABC) transporter BF39_4213 ENOG4105CJ1 ABC, transporter BF39_4214 ENOG41090WU lipolytic protein G-D-S-L family BF39_4217 ENOG4105D6E homoserine dehydrogenase BF39_4222 ENOG4108Y4K DNA-binding transcriptional activator BF39_4224 ENOG4105WH1 Two component transcriptional regulator luxr family BF39_4225 ENOG4105BZU Histidine kinase BF39_4226 ENOG4105BZU Histidine kinase BF39_4227 ENOG4105DWF phosphomethylpyrimidine kinase BF39_4228 ENOG4105BZU Histidine kinase BF39_4229 ENOG4105VCD cytoplasmic protein BF39_423 ENOG4105BZE flagellar hook protein, FlgE BF39_4230 ENOG4105D22 carbon starvation protein BF39_4231 ENOG4105DY9 regulatoR BF39_4232 ENOG41079KZ Major Facilitator Superfamily BF39_4236 ENOG4105EN6 Membrane BF39_4237 ENOG4106YBV Methyl-accepting chemotaxis BF39_4239 ENOG4108S4H thioesterase Superfamily protein BF39_4241 ENOG4105JEU Glycosyl transferase, family 2 BF39_4242 ENOG4105C5H ABC transporter BF39_4247 ENOG4105CKK Glycosyl transferase, family 2 BF39_4248 ENOG41067SE Tetr family transcriptional regulator BF39_4250 ENOG4105E0X reductase BF39_4251 ENOG4106F5Q Membrane BF39_4254 ENOG4105DY9 regulatoR BF39_4255 ENOG4108HRK Histidine kinase BF39_4256 ENOG4107RGD Major Facilitator superfamily BF39_4259 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF39_4261 ENOG4105IW1 AmiS UreI transporter BF39_4263 ENOG4105CMR udp-glucose 4-epimerase BF39_4264 ENOG4108UT2 hemolysin iii BF39_4266 ENOG4105C1J atp-dependent rna helicase BF39_4269 ENOG4105DPN Oligoendopeptidase f BF39_427 ENOG4107R88 Chemotaxis protein (CheV) BF39_4273 ENOG4105C0H protease BF39_4274 ENOG4105Q2H domain protein BF39_4277 ENOG4105BZU Histidine kinase BF39_4278 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF39_4284 ENOG4105CDU Replicative dna helicase BF39_4286 ENOG4105BZR domain protein BF39_4287 ENOG4108XMW Membrane BF39_4289 ENOG4108UUM single-stranded DNA-binding protein BF39_429 ENOG4105K64 Glycosyl transferase, family 2 BF39_4291 ENOG4105C3G gtp-binding protein BF39_4292 ENOG4105VDK protein, conserved in bacteria BF39_4293 ENOG4105D8X mechanosensitive ion channel BF39_4294 ENOG4108ZDA Sporulation protein YyaC BF39_4295 ENOG4105FA0 parb-like partition protein BF39_4296 ENOG4107QJE Chromosome Partitioning Protein BF39_4300 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BF39_4302 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF39_4306 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF39_4307 ENOG410848D S4 domain protein YaaA BF39_4310 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF39_4316 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF39_4323 ENOG4105ZMH deoxynucleoside kinase BF39_4325 ENOG4105GTG Isochorismatase BF39_4326 ENOG4108Z6B deaminase BF39_4327 ENOG4105C6E dna polymerase iii BF39_4331 ENOG41067KS pro-sigma K processing BF39_4337 ENOG4105CXN decarboxylase BF39_4339 ENOG4105FA2 dna polymerase iii BF39_4340 ENOG4105MA4 psp1 domain protein BF39_4342 ENOG41060K3 Methyltransferase BF39_4344 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BF39_4345 ENOG4105KRN Transcriptional regulator, abrb family BF39_4347 ENOG4105F8V Hydrolase, tatD family BF39_4348 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BF39_435 ENOG4107TVC Glycosyl transferase, family 2 BF39_4350 ENOG4105XFA sporulation peptidase YabG BF39_4351 ENOG4105W42 Veg protein BF39_4354 ENOG4105DFT pur operon repressor BF39_4355 ENOG4105KME endoribonuclease L-psp BF39_4358 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BF39_4359 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BF39_4361 ENOG4108JA2 transcriptioN-repair coupling factor BF39_4362 ENOG4108M14 stage v sporulation protein t BF39_4364 ENOG4108IY2 MazG family BF39_4365 ENOG41082I2 s4 domain protein BF39_4366 ENOG4105VYY sporulation protein yabp BF39_4369 ENOG41060GV RNA binding s1 domain protein BF39_4373 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BF39_4374 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BF39_4375 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF39_4376 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BF39_4379 ENOG4105C6T cysteine synthase BF39_4380 ENOG4105CRQ synthase (Component I) BF39_4381 ENOG4105DDQ anthranilate synthase BF39_4382 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BF39_4383 ENOG4105EEI dihydropteroate synthase BF39_4384 ENOG4105KRF dihydroneopterin aldolase BF39_4385 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BF39_4387 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BF39_4394 ENOG4108Z0C Uvrb UvrC protein BF39_4397 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BF39_4399 ENOG4105CTP PilT protein domain protein BF39_44 ENOG4105EYF MMPL domain protein BF39_440 ENOG4105I03 Flagellin BF39_4403 ENOG4105D7W serine acetyltransferase BF39_4406 ENOG4105C2N RNA methyltransferase TrmH family group 3 BF39_4407 ENOG4105M0M Tetracycline resistance protein BF39_4408 ENOG4105QIV RNA polymerase BF39_441 ENOG4105E4C Lytic transglycosylase catalytic BF39_4410 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BF39_4415 ENOG4107Y49 methyltransferase BF39_4417 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BF39_4418 ENOG4105XPM ribosomal protein BF39_442 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF39_4439 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BF39_444 ENOG4105DD5 Flagellar motor switch protein BF39_4444 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF39_4446 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF39_4448 ENOG41067V7 50S ribosomal protein L36 BF39_4456 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF39_4457 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF39_446 ENOG4105CN7 Flagellar biosynthetic protein FliP BF39_4462 ENOG4105D1F ATP-binding protein BF39_4465 ENOG4108NMV polysaccharide deacetylase BF39_447 ENOG4105VS8 Flagellar biosynthetic protein fliq BF39_4483 ENOG4105C8B TIGR00159 family BF39_4484 ENOG4107U5W ybbr family BF39_4486 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BF39_4487 ENOG4108VQT Alpha beta hydrolase fold protein BF39_4489 ENOG4105CMG Carbohydrate kinase BF39_449 ENOG4105D00 flagellar biosynthetic protein flhB BF39_4490 ENOG4105CMG Carbohydrate kinase BF39_4492 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BF39_4493 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BF39_450 ENOG4105D7B Flagellar biosynthesis protein flha BF39_4501 ENOG4108PSK reductase BF39_4502 ENOG4108UMI ABC transporter, permease BF39_4503 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF39_4504 ENOG4105D01 (LipO)protein BF39_4505 ENOG4105EE1 crotonyl-CoA reductase BF39_4507 ENOG4105IQ5 FAD linked oxidase domain protein BF39_451 ENOG4105FZW flagellar biosynthesis regulator FlhF BF39_4510 ENOG4105C2C drug resistance transporter, Bcr CflA BF39_4513 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF39_4514 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF39_4515 ENOG4105C3U ABC transporter BF39_4516 ENOG4108JQ7 (ABC) transporter BF39_452 ENOG4105KTQ flagellar basal-body rod protein BF39_4522 ENOG4108J59 Extracellular solute-binding protein, family 5 BF39_4523 ENOG4108J59 Extracellular solute-binding protein, family 5 BF39_4525 ENOG4105II7 pyrroline-5-carboxylate reductase BF39_4526 ENOG4107XDY Nicotinamide Mononucleotide Transporter BF39_4528 ENOG4105E0C molybdate abc transporter BF39_4529 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF39_453 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF39_4530 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF39_4531 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BF39_4534 ENOG4105EGI Transcriptional regulator BF39_4538 ENOG4105F6E Acyl-transferase BF39_4542 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF39_4545 ENOG4108RE7 deoxyribonuclease BF39_4546 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BF39_4550 ENOG4105C5H ABC transporter BF39_4553 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BF39_4555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF39_4556 ENOG4105C3U ABC transporter BF39_4557 ENOG4108JQ7 (ABC) transporter BF39_4558 ENOG410667J hydrolase BF39_4565 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BF39_4566 ENOG4105ERH Fumarylacetoacetate hydrolase BF39_4568 ENOG4108SC4 )-transporter BF39_4569 ENOG4105CPF Cell wall formation (By similarity) BF39_4570 ENOG4105CPF Cell wall formation (By similarity) BF39_4571 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF39_4573 ENOG4107ZXI Rhomboid family BF39_4576 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BF39_4577 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF39_4579 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BF39_458 ENOG4108RZE Tetr family transcriptional regulator BF39_4599 ENOG4105K8N protein family UPF0079, ATPase BF39_46 ENOG4108YBP pseudouridine synthase BF39_4600 ENOG41072GX Peptidase M22 Glycoprotease BF39_4601 ENOG410801F ribosomal-protein-alanine acetyltransferase BF39_4602 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF39_4603 ENOG4105C5H ABC transporter BF39_4606 ENOG4108TYN CAAX amino terminal protease family protein BF39_4610 ENOG4105C7N Xanthine uracil vitamin C permease BF39_4612 ENOG4105BZU Histidine kinase BF39_462 ENOG4105KAC Antibiotic biosynthesis monooxygenase BF39_4620 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF39_4626 ENOG4108SHN Glycosyl transferase, family 2 BF39_4632 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF39_4636 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF39_4640 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BF39_4641 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BF39_4642 ENOG4105C83 adenylosuccinate lyase BF39_4644 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BF39_4649 ENOG4108V3E phosphoribosylglycinamide formyltransferase BF39_4651 ENOG4105C12 Phosphoribosylglycinamide synthetase BF39_4656 ENOG4105C4R Atp-dependent dna helicase BF39_4662 ENOG4108W2Y isochorismatase BF39_4663 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF39_4664 ENOG4108UMI ABC transporter, permease BF39_4665 ENOG4105D01 (LipO)protein BF39_4669 ENOG4105D0U Arsenite-activated ATPase (ArsA) BF39_467 ENOG4105DUM transcriptional regulator, lysR family BF39_4670 ENOG410834F Transcriptional regulator BF39_4671 ENOG4107I77 yiaA/B two helix domain BF39_4675 ENOG4105CBD Diacylglycerol kinase BF39_4676 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BF39_4677 ENOG4108JPW Aminotransferase BF39_468 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF39_4680 ENOG4105C26 Dehydrogenase BF39_4681 ENOG4105KPY Small multidrug resistance protein BF39_4685 ENOG4105D9N nucleoside BF39_4686 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF39_4689 ENOG4108W15 Protein of unknown function (DUF1456) BF39_469 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF39_4692 ENOG4105DTQ mandelate racemase muconate lactonizing BF39_4693 ENOG4105DFD Na H antiporter BF39_4698 ENOG4105D3R alkyl hydroperoxide reductase BF39_4699 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BF39_470 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BF39_4701 ENOG4107W7X Aldolase BF39_4702 ENOG4105EHG Permease protein BF39_4703 ENOG4105DQ5 transport system permease protein BF39_4704 ENOG4108V5C ABC transporter BF39_4708 ENOG4106UIA BF39_4709 ENOG4106UIA BF39_471 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BF39_4713 ENOG4105BZU Histidine kinase BF39_4717 ENOG410756H nucleotidyltransferase BF39_4718 ENOG4105D2S major facilitator superfamily BF39_4721 ENOG4105E5Q amino acid AbC transporter BF39_4722 ENOG4105EAB amino acid AbC transporter BF39_4724 ENOG4105C8Q Methyl-accepting chemotaxis BF39_4725 ENOG4105C8Q Methyl-accepting chemotaxis BF39_4727 ENOG4105CI1 PTS System BF39_4733 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BF39_4736 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF39_4739 ENOG4105C5H ABC transporter BF39_4744 ENOG41062JF Transcriptional regulator BF39_4748 ENOG4105DEU major facilitator superfamily BF39_4751 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BF39_4754 ENOG4108N0M stress protein BF39_4755 ENOG4106FN3 tellurium resistance protein BF39_4756 ENOG4106FN3 tellurium resistance protein BF39_4757 ENOG4107TS3 membrane protein, TerC BF39_4758 ENOG4108TTB tellurium resistance protein BF39_4762 ENOG4105KJF protein tyrosine phosphatase BF39_4764 ENOG4107U9T Pfam:Ribonuclease_BN BF39_4765 ENOG4105C59 p-type ATPase BF39_4766 ENOG4108IPJ Membrane BF39_4768 ENOG4105C3F Signal peptidase i BF39_4771 ENOG4107ZTW SNARE associated Golgi BF39_4774 ENOG410606W general stress protein BF39_4775 ENOG4105UPD Calcium Proton BF39_478 ENOG4105CVJ phosphoglycerate mutase BF39_4783 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF39_4784 ENOG4105VTR Integrase BF39_48 ENOG4105K4I Scp-like extracellular BF39_4842 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF39_4844 ENOG4108JUB Transcriptional regulator BF39_4846 ENOG4108IQI permease BF39_485 ENOG4105CAQ asparagine synthetase BF39_4852 ENOG4105CSV Glutaminase BF39_4854 ENOG4108A04 Beta-lactamase BF39_4857 ENOG4105CKK Glycosyl transferase, family 2 BF39_4859 ENOG4107QQG Dehydrogenase BF39_4860 ENOG4105C3I Nad-dependent epimerase dehydratase BF39_4863 ENOG4105F1A Pyruvate formate-lyase BF39_4867 ENOG4105CI2 imidazolone-5-propionate hydrolase BF39_4868 ENOG4105ECP epimerase BF39_4874 ENOG41067AE Membrane-bound metal-dependent hydrolase BF39_4875 ENOG4105CEN a g-specific adenine glycosylase BF39_4876 ENOG4106BXE BF39_4880 ENOG4105BZ1 (ABC) transporter BF39_4881 ENOG4107NBY Membrane BF39_4882 ENOG4105CBC glutamate synthase BF39_4884 ENOG4108IUW ABC transporter BF39_4888 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF39_4889 ENOG4105G5W regulator Fur family BF39_489 ENOG4105PGM cation diffusion facilitator family transporter BF39_49 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF39_491 ENOG4105DRR Transcriptional regulator, GntR family BF39_4914 ENOG4108JQC penicillin-binding protein 1A BF39_4915 ENOG4107ZQN disulfide bond BF39_4917 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BF39_4919 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BF39_492 ENOG4108UZ3 Transporter BF39_4920 ENOG4105BZU Histidine kinase BF39_4922 ENOG4105CYN Serine protein kinase BF39_4926 ENOG4105C94 Transporter BF39_4929 ENOG4105DZ6 Band 7 protein BF39_493 ENOG4105CKI cobalamin synthesis protein BF39_4931 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BF39_4932 ENOG4108MRH transcriptional regulatory protein BF39_4933 ENOG4105D4T Citrate transporter BF39_4937 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF39_4938 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF39_4939 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BF39_494 ENOG4108PJD permease BF39_4940 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BF39_4941 ENOG4105BZ7 extracellular solute-binding protein family 1 BF39_4942 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BF39_4943 ENOG4108STX response regulator BF39_4944 ENOG4105US7 Histidine kinase BF39_4949 ENOG4108MRH transcriptional regulatory protein BF39_4951 ENOG4105C6K Malic enzyme BF39_4953 ENOG4108UZ3 Transporter BF39_4954 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF39_4956 ENOG4105BZU Histidine kinase BF39_4957 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF39_4959 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF39_4960 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF39_4961 ENOG4108JB9 formate dehydrogenase BF39_4966 ENOG4105CUB amino acid BF39_4968 ENOG4105C59 p-type ATPase BF39_4969 ENOG4105DAP Nicotinate phosphoribosyltransferase BF39_497 ENOG4105DFD Na H antiporter BF39_4976 ENOG41073R8 VanW family BF39_4977 ENOG4108KGH TRANSCRIPTIONal BF39_4978 ENOG4105D9N nucleoside BF39_4979 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BF39_498 ENOG4105C9Q fumarate hydratase class II BF39_4980 ENOG4105C37 (CBS) domain BF39_4981 ENOG4108IJ0 Aspartate ammonia-lyase BF39_4982 ENOG4105DAA L-lactate BF39_4985 ENOG4105DUX Transporter BF39_4986 ENOG4108MES Periplasmic binding protein BF39_4987 ENOG4105DQ5 transport system permease protein BF39_4988 ENOG4108IHU transport system permease protein BF39_4989 ENOG4105E0A ABC, transporter BF39_4990 ENOG4105DMQ Methyltransferase BF39_4992 ENOG4105EXW epimerase dehydratase BF39_4994 ENOG4107T89 von Willebrand factor, type A BF39_4995 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BF39_4996 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF39_4999 ENOG4105BZU Histidine kinase BF39_50 ENOG4105CQB FAD linked oxidase domain protein BF39_5000 ENOG4105D5Q Arginine ornithine antiporter BF39_5001 ENOG4107414 GntR family transcriptional regulator BF39_5002 ENOG4105C5Y PTS System BF39_5003 ENOG4105CG3 alpha amylase, catalytic region BF39_5007 ENOG4105E1K spore germination protein BF39_5009 ENOG4105CRN Aminoglycoside phosphotransferase BF39_5010 ENOG4105BZG amino acid carrier protein BF39_5011 ENOG4105CDA abc transporter atp-binding protein BF39_5012 ENOG4105CT1 (ABC) transporter BF39_5013 ENOG4105EAD ABC transporter BF39_5014 ENOG4105DRP amino acid AbC transporter BF39_5015 ENOG4108IQI permease BF39_502 ENOG4107QJQ Mate efflux family protein BF39_5020 ENOG4105D29 Helix-turn-helix type 11 domain protein BF39_5021 ENOG4105NAE bifunctional deaminase-reductase domain protein BF39_5022 ENOG4105BZU Histidine kinase BF39_5025 ENOG4105CHH sulfate transporter BF39_5026 ENOG41068KF Universal stress protein BF39_5028 ENOG4105DEF Extracellular solute-binding protein, family 5 BF39_503 ENOG4107QJQ Mate efflux family protein BF39_5030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF39_5031 ENOG4108JQ7 (ABC) transporter BF39_5033 ENOG4105CXY transporter BF39_5034 ENOG41067TZ transcriptional regulator, MarR family BF39_5035 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF39_5036 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF39_5037 ENOG4105ETE Transcriptional regulator (LacI family BF39_5038 ENOG4108RVA ribokinase BF39_504 ENOG4105EC3 peptidase S51, dipeptidase E BF39_5040 ENOG4105C2J ABC transporter BF39_5041 ENOG4105CNN ABC, transporter BF39_5042 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BF39_5043 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF39_5055 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF39_5056 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF39_5057 ENOG41069ER domain protein BF39_5058 ENOG4105VZ8 Transcriptional regulator BF39_5059 ENOG4107D63 BF39_5061 ENOG4105DUX Transporter BF39_5066 ENOG4105C85 amino acid BF39_5067 ENOG4105C7N Xanthine uracil vitamin C permease BF39_5075 ENOG4105BZ9 Cytochrome C oxidase, subunit I BF39_5076 ENOG4105E2S oxidase) subunit II BF39_5079 ENOG4106CAD Protein of unknown function (DUF3311) BF39_508 ENOG4107QIV Cytochrome c biogenesis protein BF39_5080 ENOG4105E1V na solute symporter BF39_5083 ENOG4108NHD germination protein BF39_5084 ENOG4105CE1 Ferrous iron transport protein b BF39_5085 ENOG4105CE1 Ferrous iron transport protein b BF39_5086 ENOG4105CE1 Ferrous iron transport protein b BF39_5087 ENOG4105CVA phosphate BF39_5088 ENOG4105C8U phosphate abc transporter BF39_5089 ENOG4105E2Z phosphate ABC transporter (Permease BF39_5118 ENOG41080XQ Signal transduction protein with cbs domains BF39_5122 ENOG4105ETU transcriptional activator (TenA BF39_5124 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF39_5126 ENOG4108VEU Thiamine monophosphate synthase BF39_5127 ENOG41080HI glycine oxidase BF39_5130 ENOG4105D06 uba thif-type nad fad binding protein BF39_5131 ENOG4105DWF phosphomethylpyrimidine kinase BF39_5140 ENOG4108INS Transcriptional regulator BF39_5143 ENOG4105C7N Xanthine uracil vitamin C permease BF39_515 ENOG4106BRA Membrane BF39_5150 ENOG4105C5Y PTS System BF39_5157 ENOG4108B31 Spore germination protein BF39_5162 ENOG4107Y03 Nitroreductase BF39_5163 ENOG4105ED1 spovr family BF39_5168 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BF39_5169 ENOG4105XTG Pfam:DUF156 BF39_5170 ENOG4105VFE sira family BF39_5171 ENOG4107TPS domain protein BF39_5172 ENOG4105VFE sira family BF39_5174 ENOG41085GJ domain protein BF39_5176 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BF39_5177 ENOG41087NI Sulfite exporter TauE/SafE BF39_5179 ENOG4108KGH TRANSCRIPTIONal BF39_5184 ENOG4105EMD TRANSCRIPTIONal BF39_5185 ENOG4105VCP PTS System BF39_5186 ENOG4105VZJ PTS System BF39_5190 ENOG41069ER domain protein BF39_5191 ENOG4107RBB ABC transporter, permease BF39_5192 ENOG4105C19 ABC transporter BF39_5198 ENOG4105WEF catalase BF39_5205 ENOG4107T5V SNARE associated Golgi BF39_5211 ENOG4105CUB amino acid BF39_5212 ENOG4107RWR Sodium hydrogen exchanger BF39_5214 ENOG4106KNT transcriptional regulator BF39_522 ENOG4105CJ1 ABC, transporter BF39_5221 ENOG4108PCN EamA-like transporter family BF39_5222 ENOG4108YXU transcriptional regulator AsnC family BF39_5224 ENOG4105KPY Small multidrug resistance protein BF39_5225 ENOG4105KPY Small multidrug resistance protein BF39_5230 ENOG4105NF4 modulator of drug activity BF39_5231 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF39_5232 ENOG4105E5W Transporter BF39_5234 ENOG4107RKG DJ-1/PfpI family BF39_5235 ENOG4105CH6 catalase BF39_5237 ENOG4105D5Q Arginine ornithine antiporter BF39_5238 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BF39_5240 ENOG4105C26 Dehydrogenase BF39_5241 ENOG4105BZ1 (ABC) transporter BF39_5242 ENOG4105BZ1 (ABC) transporter BF39_5243 ENOG4105BZ1 (ABC) transporter BF39_5245 ENOG4105DRP amino acid AbC transporter BF39_5246 ENOG4105CDA abc transporter atp-binding protein BF39_5249 ENOG410839P BF39_5256 ENOG4107FQX Alpha-acetolactate decarboxylase BF39_526 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BF39_5261 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF39_5263 ENOG4105D4P Coproporphyrinogen iii oxidase BF39_5266 ENOG4105CHH sulfate transporter BF39_5274 ENOG4106AKK s-layer domain-containing protein BF39_5276 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF39_5277 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF39_528 ENOG4108IJ0 Aspartate ammonia-lyase BF39_5280 ENOG4105CGU Enoyl-CoA hydratase BF39_5283 ENOG4105DER m42 family BF39_5287 ENOG4105CTU Proline racemase BF39_529 ENOG4105C6K Malic enzyme BF39_5295 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF39_5298 ENOG4108JQ7 (ABC) transporter BF39_53 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF39_5304 ENOG4105CSH Transporter BF39_5306 ENOG4108MRH transcriptional regulatory protein BF39_5315 ENOG4105CDU Replicative dna helicase BF39_5323 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF39_5333 ENOG4107P5I polyketide synthase BF39_5334 ENOG4108IG5 Transcriptional regulator BF39_5338 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF39_5342 ENOG4105CMT Dihydroxyacetone kinase BF39_5344 ENOG4105CMT Dihydroxyacetone kinase BF39_5345 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF39_5346 ENOG410847I Transcriptional regulator, BadM Rrf2 family BF39_5352 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BF39_5365 ENOG4105WN5 stage II sporulation protein BF39_5367 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF39_5369 ENOG4108MJI response regulator BF39_5370 ENOG4105BZU Histidine kinase BF39_5371 ENOG4105BZU Histidine kinase BF39_5376 ENOG4105K8R UPF0145 protein BF39_5382 ENOG4107VRP DNA repair exonuclease BF39_5383 ENOG4106D4I domain protein BF39_5384 ENOG4105D7V transposase BF39_5387 ENOG4108IND Tetr family transcriptional regulator BF39_5388 ENOG4105EQ0 Major Facilitator superfamily BF39_5393 ENOG4108MUZ hydrolase BF39_5397 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF39_54 ENOG4105BZU Histidine kinase BF39_5400 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BF39_5403 ENOG4105EMN RNA polymerase sigma factor BF39_5408 ENOG4105C57 major facilitator superfamily BF39_5409 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF39_5411 ENOG4105EEM helicase BF39_5412 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF39_5417 ENOG4105K59 histidine triad (HIT) protein BF39_5424 ENOG410905X membrane-flanked domain protein BF39_5426 ENOG4105CKV Membrane BF39_543 ENOG4105FVX BF39_5436 ENOG410905X membrane-flanked domain protein BF39_5437 ENOG4105CKV Membrane BF39_5438 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BF39_5439 ENOG4105BZ4 penicillin-binding protein BF39_5440 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BF39_5442 ENOG4105C1Q protoporphyrinogen oxidase BF39_5447 ENOG4105NA0 Transcriptional regulator BF39_5450 ENOG4105ECB domain protein BF39_5456 ENOG4106AXD BF39_5457 ENOG4108RQ5 Beta-lactamase domain-containing protein BF39_5458 ENOG4105DF9 Lipoate-protein, ligase BF39_5460 ENOG4105CEY Amp-dependent synthetase and ligase BF39_5466 ENOG4105CNA YD repeat protein BF39_5471 ENOG4105ENX hydrolase BF39_5473 ENOG4107RN3 metallophosphoesterase BF39_5474 ENOG4107TVP HD domain protein BF39_5476 ENOG4108AEY RNA polymerase sigma factor BF39_5477 ENOG41086D8 Transcriptional regulator BF39_5481 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF39_5486 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BF39_5487 ENOG4105C8Q Methyl-accepting chemotaxis BF39_5491 ENOG4105ZU5 s-layer protein BF39_5492 ENOG4107QP3 malate synthase g BF39_5495 ENOG4105VEQ Cold shock protein BF39_5498 ENOG4105XVF Competence transcription factor BF39_55 ENOG4105JXH GntR family transcriptional regulator BF39_5502 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BF39_5503 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BF39_551 ENOG4105CSR polyphosphate kinase 2 BF39_5511 ENOG4105ERH Fumarylacetoacetate hydrolase BF39_5516 ENOG4105CAQ asparagine synthetase BF39_5517 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BF39_5518 ENOG4105CH6 catalase BF39_5519 ENOG4105BZU Histidine kinase BF39_552 ENOG4105DXI Major Facilitator superfamily BF39_5523 ENOG4105QNR S1 RNA binding domain protein BF39_5525 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF39_5527 ENOG4107AYK membrAne BF39_5528 ENOG41073B9 BF39_553 ENOG4105DXI Major Facilitator superfamily BF39_5530 ENOG4108KP7 hydrolase BF39_5532 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BF39_5537 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF39_5538 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF39_5541 ENOG4105C31 Tryptophanyl-tRNA synthetase BF39_5544 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF39_5545 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF39_5547 ENOG4108JQ7 (ABC) transporter BF39_5548 ENOG4105UQX Mate efflux family protein BF39_5552 ENOG4108ZCF integral membrane protein BF39_5554 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF39_5556 ENOG4105DPN Oligoendopeptidase f BF39_5559 ENOG4108Z18 K06886 hemoglobin BF39_556 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF39_5560 ENOG4105MIX Adenylate cyclase BF39_5563 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BF39_5564 ENOG4105EMS pseudouridine synthase BF39_5567 ENOG4105CNI cell division protein FtsW BF39_5569 ENOG4105K64 Glycosyl transferase, family 2 BF39_5573 ENOG4107TVC Glycosyl transferase, family 2 BF39_5577 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BF39_5578 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BF39_5580 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BF39_5589 ENOG4108WVJ 2'-5' rna ligase BF39_559 ENOG4105EU0 Major facilitator Superfamily BF39_5594 ENOG4105CK7 Sodium proline symporter BF39_5595 ENOG4105CRQ synthase (Component I) BF39_5596 ENOG4105DDQ anthranilate synthase BF39_560 ENOG4105C6T cysteine synthase BF39_5612 ENOG4105KRN Transcriptional regulator, abrb family BF39_5614 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF39_5621 ENOG4108IBT Inherit from COG: transposase BF39_5623 ENOG4105DQ6 Transposase BF39_5624 ENOG4105DQ6 Transposase BF39_5627 ENOG4105DQ6 Transposase BF39_5630 ENOG4108MEK Metal-binding protein YodA BF39_5632 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) BF39_5639 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF39_564 ENOG4105C8J )-transporter BF39_566 ENOG4105X5K response regulator receiver protein BF39_5660 ENOG4105EKQ RNA-directed DNA polymerase BF39_567 ENOG4105H67 Protein of unknown function (DUF421) BF39_5681 ENOG4105EKQ RNA-directed DNA polymerase BF39_5693 ENOG4106JUT Streptomycin 3''-adenylyltransferase BF39_570 ENOG4106KE4 Dehydrogenase BF39_5708 ENOG4105CNU cell division protein FtsK BF39_574 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF39_575 ENOG4105CHR reductase BF39_5757 ENOG4105DHF Membrane BF39_576 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF39_5763 ENOG4106AKK s-layer domain-containing protein BF39_5764 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF39_5768 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF39_5769 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF39_577 ENOG4105C7K acetolactate synthase BF39_5770 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF39_5776 ENOG4105DQ6 Transposase BF39_578 ENOG4108ZP8 Acetolactate synthase small subunit BF39_5785 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BF39_579 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF39_5791 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF39_581 ENOG4105C7B Threonine dehydratase BF39_5832 ENOG4105K4H Nlp p60 protein BF39_5846 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF39_5847 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF39_5857 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF39_586 ENOG4105C6X Major Facilitator BF39_5860 ENOG4108J59 Extracellular solute-binding protein, family 5 BF39_5866 ENOG4105N14 lysine exporter protein LysE YggA BF39_587 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BF39_5874 ENOG4105C3F Signal peptidase i BF39_589 ENOG4105DY9 regulatoR BF39_5893 ENOG4105EWC Purine nucleoside phosphorylase BF39_59 ENOG4106A3R peptidase BF39_590 ENOG4105CYC Transferase BF39_5900 ENOG4105DQ6 Transposase BF39_5904 ENOG4107QJE Chromosome Partitioning Protein BF39_595 ENOG4105F6J Alpha beta hydrolase fold BF39_596 ENOG4108J59 Extracellular solute-binding protein, family 5 BF39_602 ENOG41068WN BF39_607 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BF39_608 ENOG4105C72 UPF0176 protein BF39_61 ENOG4108QTI )-transporter BF39_610 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BF39_612 ENOG4105C0X amino acid BF39_613 ENOG4105C0X amino acid BF39_618 ENOG4107RHR regulatoR BF39_62 ENOG4107TS3 membrane protein, TerC BF39_620 ENOG4105D9N nucleoside BF39_621 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BF39_627 ENOG4107RAQ aminopeptidase BF39_628 ENOG4107STQ Multicopper oxidase BF39_629 ENOG4107R16 Multicopper oxidase BF39_639 ENOG4108T5E Copper resistance protein BF39_640 ENOG4105KTB nuclear export factor GLE1 BF39_642 ENOG4107RT3 EamA-like transporter family BF39_643 ENOG4105GZI Transcriptional regulator BF39_644 ENOG4108Z40 Transcriptional regulator BF39_645 ENOG4107ZXU DSBA oxidoreductase BF39_646 ENOG4108TVJ Nitroreductase BF39_648 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF39_649 ENOG4106F5Q Membrane BF39_65 ENOG410681C small acid-soluble spore protein BF39_650 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF39_652 ENOG4105CKI cobalamin synthesis protein BF39_656 ENOG4108Z7G MaoC domain protein dehydratase BF39_657 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF39_659 ENOG4105C0Z ABC transporter BF39_66 ENOG4108Z7G MaoC domain protein dehydratase BF39_660 ENOG4108IV0 ABC, transporter BF39_661 ENOG4105C32 Amino acid ABC transporter (Permease) BF39_663 ENOG4105SKE transcriptional Regulator LysR family BF39_667 ENOG4105YGB Transcriptional regulator BF39_669 ENOG4105C4M (Ubiquinol oxidase) subunit I BF39_670 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF39_671 ENOG4108JJ9 ABC, transporter BF39_672 ENOG4108JJ8 (ABC) transporter BF39_680 ENOG4105BZ1 (ABC) transporter BF39_681 ENOG4105BZ1 (ABC) transporter BF39_682 ENOG4105EFI regulatoR BF39_683 ENOG4105BZU Histidine kinase BF39_686 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BF39_687 ENOG4108ZJ4 polysaccharide deacetylase BF39_691 ENOG4105D6E homoserine dehydrogenase BF39_696 ENOG4108KGH TRANSCRIPTIONal BF39_698 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF39_699 ENOG4105BZU Histidine kinase BF39_70 ENOG4105CHR reductase BF39_700 ENOG4107VMI polysaccharide deacetylase BF39_702 ENOG4105KT7 mgtC SapB transporter BF39_703 ENOG4105VRR gCN5-related N-acetyltransferase BF39_705 ENOG4105DUU IucA IucC family protein BF39_706 ENOG4105CEY Amp-dependent synthetase and ligase BF39_709 ENOG4108WBH protein TIM barrel BF39_710 ENOG4105YWU small acid-soluble spore protein BF39_712 ENOG4107RCC Major Facilitator Superfamily BF39_714 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF39_72 ENOG4105MWK D-amino acid dehydrogenase, small subunit BF39_725 ENOG4105KRN Transcriptional regulator, abrb family BF39_727 ENOG4105YVS arsR family transcriptional regulator BF39_728 ENOG4107SET aldo keto reductase BF39_729 ENOG4107XZQ multidrug resistance protein BF39_734 ENOG4105C8Q Methyl-accepting chemotaxis BF39_737 ENOG4108K88 Membrane BF39_738 ENOG4108WPJ Ferritin-like domain BF39_741 ENOG4105DEN Luciferase family BF39_745 ENOG4107QM2 Aldo Keto reductase BF39_746 ENOG4105CKI cobalamin synthesis protein BF39_757 ENOG4105DSE periplasmic solute binding protein BF39_759 ENOG4105K4T epimerase BF39_76 ENOG4105C4Y ABC transporter BF39_761 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF39_766 ENOG4105CVJ phosphoglycerate mutase BF39_770 ENOG4107T5V SNARE associated Golgi BF39_773 ENOG4108PJD permease BF39_775 ENOG4108S4H thioesterase Superfamily protein BF39_776 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF39_78 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF39_780 ENOG4105SXS Protein of unknown function (DUF456) BF39_781 ENOG4105C37 (CBS) domain BF39_785 ENOG4108Z7R Chaperone CsaA BF39_789 ENOG4108ZRV stage ii sporulation protein p BF39_791 ENOG4108VXD carboxy-peptidase BF39_793 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF39_798 ENOG4108X4Q Hydrolase BF39_800 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF39_801 ENOG4107RBS Methyltransferase BF39_804 ENOG41087PP glycosyltransferase MGT family BF39_805 ENOG4108JYZ YitT family BF39_806 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF39_81 ENOG4107RCV ABC transporter, permease BF39_812 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF39_82 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BF39_821 ENOG4105KBJ sporulation protein ytfj BF39_826 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF39_830 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BF39_831 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BF39_833 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BF39_834 ENOG4105EMN RNA polymerase sigma factor BF39_839 ENOG4108V06 Glutathione peroxidase BF39_842 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF39_846 ENOG4108IUE nitrate reductase beta subunit BF39_847 ENOG4105R3A Nitrate reductase BF39_85 ENOG4105E98 transcriptional regulator DeoR family BF39_852 ENOG4107V6Q Cyclic nucleotide-binding domain BF39_853 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF39_854 ENOG4105D06 uba thif-type nad fad binding protein BF39_855 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF39_856 ENOG4108ZAF Molybdopterin BF39_861 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF39_862 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF39_863 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF39_864 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BF39_865 ENOG4108IFG nitrite reductase, (NAD(P)H) BF39_866 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF39_873 ENOG4105MCT stage V sporulation protein S BF39_876 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF39_880 ENOG4105C5H ABC transporter BF39_883 ENOG4108UUM single-stranded DNA-binding protein BF39_886 ENOG41061H0 Monooxygenase BF39_890 ENOG4107YX5 Pfam:DUF548 BF39_891 ENOG4105C75 arginyL-tRNA synthetase BF39_897 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF39_90 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF39_900 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF39_901 ENOG4105C5S asparaginyl-tRNA synthetase BF39_905 ENOG4105EC2 ftsk spoIIIe BF39_91 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF39_924 ENOG4105BZW Glycerate kinase BF39_925 ENOG4107QPK )-transporter BF39_926 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF39_927 ENOG41062D9 Histidine kinase BF39_93 ENOG4105PXI polysaccharide deacetylase BF39_930 ENOG4105C8J )-transporter BF39_936 ENOG4105CY2 Citrate transporter BF39_937 ENOG4105C0A alcohol dehydrogenase BF39_940 ENOG4105KD7 acetyltransferase BF39_942 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BF39_947 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BF39_95 ENOG4105BZU Histidine kinase BF39_951 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BF39_954 ENOG4107RVG penicillin-binding protein BF39_955 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF39_956 ENOG4105E9Q Acyl-transferase BF39_957 ENOG4108UT2 hemolysin iii BF39_959 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BF39_96 ENOG41090MY MarR family Transcriptional regulator BF39_961 ENOG4108RCR degv family BF39_962 ENOG4105E8R UPF0173 metal-dependent hydrolase BF39_963 ENOG4108KF3 Electron transport protein SCO1 SenC BF39_964 ENOG4107Y70 Heat shock protein BF39_965 ENOG4105CAQ asparagine synthetase BF39_969 ENOG4108MES Periplasmic binding protein BF39_970 ENOG4105F0I Aminotransferase BF39_977 ENOG4105D8X mechanosensitive ion channel BF39_978 ENOG4105BZU Histidine kinase BF39_979 ENOG4105WH1 Two component transcriptional regulator luxr family BF39_98 ENOG4106DF1 BF39_981 ENOG4106KNT transcriptional regulator BF39_989 ENOG4105CMG Carbohydrate kinase BF39_990 ENOG4105CMG Carbohydrate kinase BF39_996 ENOG4108IJ8 ABC transporter BF39_997 ENOG4105E90 ABC transporter