locus-tag class description BAA_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BAA_0003 ENOG410848D S4 domain protein YaaA BAA_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BAA_0014 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BAA_0021 ENOG4105ZMH deoxynucleoside kinase BAA_0023 ENOG4105GTG Isochorismatase BAA_0024 ENOG4108Z6B deaminase BAA_0026 ENOG4105C6E dna polymerase iii BAA_0030 ENOG41067KS pro-sigma K processing BAA_0038 ENOG4105CXN decarboxylase BAA_0040 ENOG4105FA2 dna polymerase iii BAA_0041 ENOG4105MA4 psp1 domain protein BAA_0043 ENOG41060K3 Methyltransferase BAA_0045 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BAA_0046 ENOG4105KRN Transcriptional regulator, abrb family BAA_0048 ENOG4105F8V Hydrolase, tatD family BAA_0049 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BAA_0051 ENOG4105XFA sporulation peptidase YabG BAA_0052 ENOG4105W42 Veg protein BAA_0055 ENOG4105DFT pur operon repressor BAA_0057 ENOG4105KME endoribonuclease L-psp BAA_0060 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BAA_0061 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BAA_0063 ENOG4108JA2 transcriptioN-repair coupling factor BAA_0064 ENOG4108M14 stage v sporulation protein t BAA_0066 ENOG4108IY2 MazG family BAA_0067 ENOG41082I2 s4 domain protein BAA_0068 ENOG4105VYY sporulation protein yabp BAA_0071 ENOG41060GV RNA binding s1 domain protein BAA_0075 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BAA_0076 ENOG4108UGV hypoxanthine phosphoribosyltransferase BAA_0077 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BAA_0080 ENOG4105C6T cysteine synthase BAA_0081 ENOG4105CRQ synthase (Component I) BAA_0082 ENOG4105DDQ anthranilate synthase BAA_0083 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BAA_0084 ENOG4105EEI dihydropteroate synthase BAA_0085 ENOG4105KRF dihydroneopterin aldolase BAA_0086 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BAA_0088 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BAA_0095 ENOG4108Z0C Uvrb UvrC protein BAA_0098 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BAA_0100 ENOG4105CTP PilT protein domain protein BAA_0104 ENOG4105D7W serine acetyltransferase BAA_0107 ENOG4105C2N RNA methyltransferase TrmH family group 3 BAA_0108 ENOG4105M0M Tetracycline resistance protein BAA_0109 ENOG4105QIV RNA polymerase BAA_0111 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BAA_0117 ENOG4107Y49 methyltransferase BAA_0119 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BAA_0120 ENOG4105XPM ribosomal protein BAA_0141 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BAA_0146 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BAA_0148 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BAA_0150 ENOG41067V7 50S ribosomal protein L36 BAA_0156 ENOG4108JJB ABC transporter BAA_0157 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BAA_0158 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BAA_0164 ENOG4105D1F ATP-binding protein BAA_0167 ENOG4108NMV polysaccharide deacetylase BAA_0185 ENOG4105C8B TIGR00159 family BAA_0186 ENOG4107U5W ybbr family BAA_0189 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BAA_0190 ENOG4108VQT Alpha beta hydrolase fold protein BAA_0195 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BAA_0196 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BAA_0205 ENOG4108UMI ABC transporter, permease BAA_0206 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BAA_0207 ENOG4105D01 (LipO)protein BAA_0209 ENOG4105EE1 crotonyl-CoA reductase BAA_0211 ENOG4105IQ5 FAD linked oxidase domain protein BAA_0214 ENOG4105C2C drug resistance transporter, Bcr CflA BAA_0218 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BAA_0219 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BAA_0220 ENOG4105C3U ABC transporter BAA_0221 ENOG4108JQ7 (ABC) transporter BAA_0227 ENOG4108J59 Extracellular solute-binding protein, family 5 BAA_0228 ENOG4108J59 Extracellular solute-binding protein, family 5 BAA_0232 ENOG4107XDY Nicotinamide Mononucleotide Transporter BAA_0234 ENOG4105E0C molybdate abc transporter BAA_0237 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BAA_0238 ENOG4105EGI Transcriptional regulator BAA_0241 ENOG4105F6E Acyl-transferase BAA_0245 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BAA_0248 ENOG4108RE7 deoxyribonuclease BAA_0249 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BAA_0255 ENOG4105C5H ABC transporter BAA_0258 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BAA_0260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BAA_0261 ENOG4105C3U ABC transporter BAA_0267 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BAA_0268 ENOG4105ERH Fumarylacetoacetate hydrolase BAA_0270 ENOG4108SC4 )-transporter BAA_0272 ENOG4105CPF Cell wall formation (By similarity) BAA_0273 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BAA_0275 ENOG4107ZXI Rhomboid family BAA_0278 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BAA_0279 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BAA_0281 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BAA_0301 ENOG4105K8N protein family UPF0079, ATPase BAA_0302 ENOG41072GX Peptidase M22 Glycoprotease BAA_0303 ENOG410801F ribosomal-protein-alanine acetyltransferase BAA_0304 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BAA_0305 ENOG4105C5H ABC transporter BAA_0307 ENOG4108TYN CAAX amino terminal protease family protein BAA_0313 ENOG4105C7N Xanthine uracil vitamin C permease BAA_0315 ENOG4105BZU Histidine kinase BAA_0322 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BAA_0333 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BAA_0337 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BAA_0343 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BAA_0344 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BAA_0345 ENOG4105C83 adenylosuccinate lyase BAA_0347 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BAA_0352 ENOG4108V3E phosphoribosylglycinamide formyltransferase BAA_0354 ENOG4105C12 Phosphoribosylglycinamide synthetase BAA_0359 ENOG4105C4R Atp-dependent dna helicase BAA_0365 ENOG4108W2Y isochorismatase BAA_0367 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BAA_0368 ENOG4108UMI ABC transporter, permease BAA_0369 ENOG4105D01 (LipO)protein BAA_0374 ENOG410834F Transcriptional regulator BAA_0379 ENOG4105CBD Diacylglycerol kinase BAA_0380 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BAA_0381 ENOG4108JPW Aminotransferase BAA_0383 ENOG4105C26 Dehydrogenase BAA_0384 ENOG4105KPY Small multidrug resistance protein BAA_0388 ENOG4105D9N nucleoside BAA_0390 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BAA_0393 ENOG4108W15 Protein of unknown function (DUF1456) BAA_0396 ENOG4105DTQ mandelate racemase muconate lactonizing BAA_0397 ENOG4105DFD Na H antiporter BAA_0402 ENOG4105D3R alkyl hydroperoxide reductase BAA_0403 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BAA_0405 ENOG4107W7X Aldolase BAA_0406 ENOG4105EHG Permease protein BAA_0407 ENOG4105DQ5 transport system permease protein BAA_0408 ENOG4108V5C ABC transporter BAA_0412 ENOG4106UIA BAA_0413 ENOG4106UIA BAA_0423 ENOG410756H nucleotidyltransferase BAA_0424 ENOG4105D2S major facilitator superfamily BAA_0427 ENOG4105E5Q amino acid AbC transporter BAA_0428 ENOG4105EAB amino acid AbC transporter BAA_0430 ENOG4105C8Q Methyl-accepting chemotaxis BAA_0431 ENOG4105C8Q Methyl-accepting chemotaxis BAA_0433 ENOG4105CI1 PTS System BAA_0441 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BAA_0445 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BAA_0448 ENOG4105C5H ABC transporter BAA_0453 ENOG41062JF Transcriptional regulator BAA_0457 ENOG4105DEU major facilitator superfamily BAA_0463 ENOG4108N0M stress protein BAA_0464 ENOG4106FN3 tellurium resistance protein BAA_0465 ENOG4106FN3 tellurium resistance protein BAA_0466 ENOG4107TS3 membrane protein, TerC BAA_0467 ENOG4108TTB tellurium resistance protein BAA_0471 ENOG4105KJF protein tyrosine phosphatase BAA_0473 ENOG4107U9T Pfam:Ribonuclease_BN BAA_0474 ENOG4105C59 p-type ATPase BAA_0475 ENOG4108IPJ Membrane BAA_0480 ENOG4107ZTW SNARE associated Golgi BAA_0483 ENOG410606W general stress protein BAA_0484 ENOG4105UPD Calcium Proton BAA_0492 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BAA_0493 ENOG4105VTR Integrase BAA_0549 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BAA_0551 ENOG4108JUB Transcriptional regulator BAA_0553 ENOG4108IQI permease BAA_0559 ENOG4105CSV Glutaminase BAA_0562 ENOG4108A04 Beta-lactamase BAA_0565 ENOG4105CKK Glycosyl transferase, family 2 BAA_0567 ENOG4107QQG Dehydrogenase BAA_0568 ENOG4105C3I Nad-dependent epimerase dehydratase BAA_0571 ENOG4105F1A Pyruvate formate-lyase BAA_0575 ENOG4105CI2 imidazolone-5-propionate hydrolase BAA_0576 ENOG4105ECP epimerase BAA_0582 ENOG41067AE Membrane-bound metal-dependent hydrolase BAA_0583 ENOG4105CEN a g-specific adenine glycosylase BAA_0584 ENOG4106BXE BAA_0590 ENOG4105BZ1 (ABC) transporter BAA_0591 ENOG4107NBY Membrane BAA_0592 ENOG4105CBC glutamate synthase BAA_0594 ENOG4108IUW ABC transporter BAA_0598 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BAA_0599 ENOG4105G5W regulator Fur family BAA_0624 ENOG4108JQC penicillin-binding protein 1A BAA_0625 ENOG4107ZQN disulfide bond BAA_0627 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BAA_0629 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BAA_0630 ENOG4105BZU Histidine kinase BAA_0632 ENOG4105CYN Serine protein kinase BAA_0636 ENOG4105C94 Transporter BAA_0639 ENOG4105DZ6 Band 7 protein BAA_0641 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BAA_0644 ENOG4105D4T Citrate transporter BAA_0648 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BAA_0649 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BAA_0650 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BAA_0651 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BAA_0652 ENOG4105BZ7 extracellular solute-binding protein family 1 BAA_0653 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BAA_0654 ENOG4108STX response regulator BAA_0655 ENOG4105US7 Histidine kinase BAA_0660 ENOG4108MRH transcriptional regulatory protein BAA_0662 ENOG4105C6K Malic enzyme BAA_0664 ENOG4108UZ3 Transporter BAA_0665 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BAA_0667 ENOG4105BZU Histidine kinase BAA_0668 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAA_0670 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BAA_0671 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BAA_0672 ENOG4108JB9 formate dehydrogenase BAA_0677 ENOG4105CUB amino acid BAA_0679 ENOG4105C59 p-type ATPase BAA_0680 ENOG4105DAP Nicotinate phosphoribosyltransferase BAA_0687 ENOG41073R8 VanW family BAA_0688 ENOG4108KGH TRANSCRIPTIONal BAA_0689 ENOG4105D9N nucleoside BAA_0690 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BAA_0691 ENOG4105C37 (CBS) domain BAA_0692 ENOG4108IJ0 Aspartate ammonia-lyase BAA_0693 ENOG4105DAA L-lactate BAA_0696 ENOG4105DUX Transporter BAA_0697 ENOG4108MES Periplasmic binding protein BAA_0698 ENOG4105DQ5 transport system permease protein BAA_0699 ENOG4108IHU transport system permease protein BAA_0700 ENOG4105E0A ABC, transporter BAA_0701 ENOG4105DMQ Methyltransferase BAA_0705 ENOG4107T89 von Willebrand factor, type A BAA_0706 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BAA_0707 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BAA_0710 ENOG4105BZU Histidine kinase BAA_0711 ENOG4105D5Q Arginine ornithine antiporter BAA_0712 ENOG4107414 GntR family transcriptional regulator BAA_0713 ENOG4105C5Y PTS System BAA_0714 ENOG4105CG3 alpha amylase, catalytic region BAA_0717 ENOG4105E1K spore germination protein BAA_0719 ENOG4105CRN Aminoglycoside phosphotransferase BAA_0720 ENOG4105BZG amino acid carrier protein BAA_0721 ENOG4105CDA abc transporter atp-binding protein BAA_0722 ENOG4105CT1 (ABC) transporter BAA_0723 ENOG4105EAD ABC transporter BAA_0724 ENOG4105DRP amino acid AbC transporter BAA_0725 ENOG4108IQI permease BAA_0730 ENOG4105D29 Helix-turn-helix type 11 domain protein BAA_0731 ENOG4105NAE bifunctional deaminase-reductase domain protein BAA_0732 ENOG4105BZU Histidine kinase BAA_0736 ENOG4105CHH sulfate transporter BAA_0737 ENOG41068KF Universal stress protein BAA_0739 ENOG4105DEF Extracellular solute-binding protein, family 5 BAA_0741 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BAA_0742 ENOG4108JQ7 (ABC) transporter BAA_0744 ENOG4105CXY transporter BAA_0745 ENOG41067TZ transcriptional regulator, MarR family BAA_0748 ENOG4105ETE Transcriptional regulator (LacI family BAA_0749 ENOG4108RVA ribokinase BAA_0751 ENOG4105C2J ABC transporter BAA_0752 ENOG4105CNN ABC, transporter BAA_0753 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BAA_0754 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BAA_0766 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BAA_0767 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BAA_0768 ENOG41069ER domain protein BAA_0769 ENOG4105VZ8 Transcriptional regulator BAA_0770 ENOG4107D63 BAA_0772 ENOG4105DUX Transporter BAA_0776 ENOG4105C85 amino acid BAA_0777 ENOG4105C7N Xanthine uracil vitamin C permease BAA_0785 ENOG4105BZ9 Cytochrome C oxidase, subunit I BAA_0786 ENOG4105E2S oxidase) subunit II BAA_0789 ENOG4106CAD Protein of unknown function (DUF3311) BAA_0790 ENOG4105E1V na solute symporter BAA_0793 ENOG4108NHD germination protein BAA_0795 ENOG4105CE1 Ferrous iron transport protein b BAA_0796 ENOG4105CE1 Ferrous iron transport protein b BAA_0797 ENOG4105CE1 Ferrous iron transport protein b BAA_0798 ENOG4105CVA phosphate BAA_0799 ENOG4105C8U phosphate abc transporter BAA_0800 ENOG4105E2Z phosphate ABC transporter (Permease BAA_0825 ENOG41080XQ Signal transduction protein with cbs domains BAA_0832 ENOG4105ETU transcriptional activator (TenA BAA_0834 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BAA_0836 ENOG4108VEU Thiamine monophosphate synthase BAA_0837 ENOG41080HI glycine oxidase BAA_0840 ENOG4105D06 uba thif-type nad fad binding protein BAA_0841 ENOG4105DWF phosphomethylpyrimidine kinase BAA_0852 ENOG4108INS Transcriptional regulator BAA_0855 ENOG4105C7N Xanthine uracil vitamin C permease BAA_0862 ENOG4105C5Y PTS System BAA_0875 ENOG4107Y03 Nitroreductase BAA_0876 ENOG4105ED1 spovr family BAA_0882 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BAA_0883 ENOG4105XTG Pfam:DUF156 BAA_0884 ENOG4105VFE sira family BAA_0885 ENOG4107TPS domain protein BAA_0886 ENOG4105VFE sira family BAA_0890 ENOG41087NI Sulfite exporter TauE/SafE BAA_0892 ENOG4108KGH TRANSCRIPTIONal BAA_0898 ENOG4105EMD TRANSCRIPTIONal BAA_0899 ENOG4105VCP PTS System BAA_0900 ENOG4105VZJ PTS System BAA_0904 ENOG41069ER domain protein BAA_0905 ENOG4107RBB ABC transporter, permease BAA_0906 ENOG4105C19 ABC transporter BAA_0913 ENOG4105WEF catalase BAA_0921 ENOG4107T5V SNARE associated Golgi BAA_0927 ENOG4105CUB amino acid BAA_0928 ENOG4107RWR Sodium hydrogen exchanger BAA_0930 ENOG4106KNT transcriptional regulator BAA_0937 ENOG4108PCN EamA-like transporter family BAA_0938 ENOG4108YXU transcriptional regulator AsnC family BAA_0940 ENOG4105KPY Small multidrug resistance protein BAA_0941 ENOG4105KPY Small multidrug resistance protein BAA_0946 ENOG4105NF4 modulator of drug activity BAA_0947 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BAA_0948 ENOG4105E5W Transporter BAA_0950 ENOG4107RKG DJ-1/PfpI family BAA_0951 ENOG4105CH6 catalase BAA_0953 ENOG4105D5Q Arginine ornithine antiporter BAA_0955 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BAA_0957 ENOG4105C26 Dehydrogenase BAA_0958 ENOG4105BZ1 (ABC) transporter BAA_0962 ENOG4105DRP amino acid AbC transporter BAA_0963 ENOG4105CDA abc transporter atp-binding protein BAA_0966 ENOG410839P BAA_0973 ENOG4107FQX Alpha-acetolactate decarboxylase BAA_0980 ENOG4105D4P Coproporphyrinogen iii oxidase BAA_0983 ENOG4105CHH sulfate transporter BAA_0991 ENOG4106AKK s-layer domain-containing protein BAA_0993 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BAA_0994 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BAA_0997 ENOG4105CGU Enoyl-CoA hydratase BAA_1000 ENOG4105DER m42 family BAA_1004 ENOG4105CTU Proline racemase BAA_1013 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BAA_1016 ENOG4108JQ7 (ABC) transporter BAA_1022 ENOG4105CSH Transporter BAA_1024 ENOG4108MRH transcriptional regulatory protein BAA_1035 ENOG4105CDU Replicative dna helicase BAA_1043 ENOG4105C0R drug resistance transporter emrb qaca subfamily BAA_1052 ENOG4107P5I polyketide synthase BAA_1053 ENOG4108IG5 Transcriptional regulator BAA_1057 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BAA_1061 ENOG4105CMT Dihydroxyacetone kinase BAA_1063 ENOG4105CMT Dihydroxyacetone kinase BAA_1064 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BAA_1065 ENOG410847I Transcriptional regulator, BadM Rrf2 family BAA_1072 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BAA_1084 ENOG4105WN5 stage II sporulation protein BAA_1086 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BAA_1088 ENOG4108MJI response regulator BAA_1089 ENOG4105BZU Histidine kinase BAA_1090 ENOG4105BZU Histidine kinase BAA_1095 ENOG4105K8R UPF0145 protein BAA_1102 ENOG4107VRP DNA repair exonuclease BAA_1103 ENOG4106D4I domain protein BAA_1105 ENOG4105D7V transposase BAA_1108 ENOG4108IND Tetr family transcriptional regulator BAA_1109 ENOG4105EQ0 Major Facilitator superfamily BAA_1114 ENOG4108MUZ hydrolase BAA_1118 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BAA_1121 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BAA_1124 ENOG4105EMN RNA polymerase sigma factor BAA_1129 ENOG4105C57 major facilitator superfamily BAA_1130 ENOG4105C0R drug resistance transporter emrb qaca subfamily BAA_1132 ENOG4105EEM helicase BAA_1133 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BAA_1138 ENOG4105K59 histidine triad (HIT) protein BAA_1145 ENOG410905X membrane-flanked domain protein BAA_1155 ENOG410905X membrane-flanked domain protein BAA_1156 ENOG4105CKV Membrane BAA_1157 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BAA_1158 ENOG4105BZ4 penicillin-binding protein BAA_1159 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BAA_1161 ENOG4105C1Q protoporphyrinogen oxidase BAA_1166 ENOG4105NA0 Transcriptional regulator BAA_1169 ENOG4105ECB domain protein BAA_1175 ENOG4106AXD BAA_1176 ENOG4108RQ5 Beta-lactamase domain-containing protein BAA_1177 ENOG4105DF9 Lipoate-protein, ligase BAA_1179 ENOG4105CEY Amp-dependent synthetase and ligase BAA_1185 ENOG4105CNA YD repeat protein BAA_1193 ENOG4105ENX hydrolase BAA_1196 ENOG4107TVP HD domain protein BAA_1198 ENOG4108AEY RNA polymerase sigma factor BAA_1199 ENOG41086D8 Transcriptional regulator BAA_1203 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BAA_1208 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BAA_1209 ENOG4105C8Q Methyl-accepting chemotaxis BAA_1214 ENOG4105ZU5 s-layer protein BAA_1215 ENOG4107QP3 malate synthase g BAA_1218 ENOG4105VEQ Cold shock protein BAA_1221 ENOG4105XVF Competence transcription factor BAA_1224 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BAA_1225 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BAA_1234 ENOG4105ERH Fumarylacetoacetate hydrolase BAA_1239 ENOG4105CAQ asparagine synthetase BAA_1240 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BAA_1241 ENOG4105CH6 catalase BAA_1247 ENOG4105QNR S1 RNA binding domain protein BAA_1249 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BAA_1251 ENOG4107AYK membrAne BAA_1252 ENOG41073B9 BAA_1254 ENOG4108KP7 hydrolase BAA_1256 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BAA_1261 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BAA_1262 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BAA_1265 ENOG4105C31 Tryptophanyl-tRNA synthetase BAA_1268 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BAA_1269 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BAA_1271 ENOG4108JQ7 (ABC) transporter BAA_1272 ENOG4105UQX Mate efflux family protein BAA_1277 ENOG4108ZCF integral membrane protein BAA_1279 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BAA_1281 ENOG4105DPN Oligoendopeptidase f BAA_1284 ENOG4108Z18 K06886 hemoglobin BAA_1285 ENOG4105MIX Adenylate cyclase BAA_1288 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BAA_1289 ENOG4105EMS pseudouridine synthase BAA_1295 ENOG4105K64 Glycosyl transferase, family 2 BAA_1300 ENOG4107TVC Glycosyl transferase, family 2 BAA_1304 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BAA_1305 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BAA_1307 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BAA_1317 ENOG4108WVJ 2'-5' rna ligase BAA_1322 ENOG4105CK7 Sodium proline symporter BAA_1324 ENOG4105CRQ synthase (Component I) BAA_1325 ENOG4105DDQ anthranilate synthase BAA_1343 ENOG4105C7S Dehydrogenase BAA_1345 ENOG4105VZ8 Transcriptional regulator BAA_1355 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BAA_1357 ENOG4105DZ1 carboxypeptidase BAA_1358 ENOG4105VFR signal peptidase BAA_1364 ENOG4105C26 Dehydrogenase BAA_1365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BAA_1366 ENOG4105F38 ABC transporter, permease BAA_1368 ENOG4107RUE extracellular solute-binding protein family 1 BAA_1370 ENOG4105EYF MMPL domain protein BAA_1372 ENOG4108YBP pseudouridine synthase BAA_1374 ENOG4105K4I Scp-like extracellular BAA_1375 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BAA_1376 ENOG4105CQB FAD linked oxidase domain protein BAA_1379 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAA_1380 ENOG4105BZU Histidine kinase BAA_1381 ENOG4105JXH GntR family transcriptional regulator BAA_1385 ENOG4106A3R peptidase BAA_1388 ENOG4108QTI )-transporter BAA_1389 ENOG4107TS3 membrane protein, TerC BAA_1391 ENOG4105CZN Potassium uptake protein BAA_1392 ENOG410681C small acid-soluble spore protein BAA_1393 ENOG4108Z7G MaoC domain protein dehydratase BAA_1397 ENOG4105CHR reductase BAA_1399 ENOG4105MWK D-amino acid dehydrogenase, small subunit BAA_1403 ENOG4105C4Y ABC transporter BAA_1407 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BAA_1410 ENOG4105E98 transcriptional regulator DeoR family BAA_1418 ENOG4105PXI polysaccharide deacetylase BAA_1420 ENOG4105BZU Histidine kinase BAA_1421 ENOG41090MY MarR family Transcriptional regulator BAA_1423 ENOG4106DF1 BAA_1425 ENOG4105BZU Histidine kinase BAA_1428 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BAA_1429 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BAA_1437 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BAA_1438 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BAA_1440 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BAA_1441 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BAA_1442 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BAA_1443 ENOG4105CZV ABC transporter BAA_1445 ENOG4105CJ1 ABC, transporter BAA_1453 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BAA_1454 ENOG4105EA8 2-Nitropropane dioxygenase BAA_1455 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BAA_1457 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BAA_1462 ENOG4105NQC Flavodoxin BAA_1469 ENOG4107QMU Mate efflux family protein BAA_1470 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BAA_1476 ENOG4105CZN Potassium uptake protein BAA_1477 ENOG41063Y9 BAA_1478 ENOG4105KBJ sporulation protein ytfj BAA_1483 ENOG4105CM2 brancheD-chain amino acid aminotransferase BAA_1484 ENOG4105C7K acetolactate synthase BAA_1485 ENOG4108ZP8 Acetolactate synthase small subunit BAA_1486 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BAA_1488 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BAA_1493 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BAA_1500 ENOG4107RVV histidinol phosphate phosphatase, hisj family BAA_1503 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BAA_1504 ENOG4105E0M Sulfatase BAA_1507 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BAA_1512 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BAA_1513 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BAA_1515 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BAA_1516 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BAA_1517 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BAA_1518 ENOG4105C8J )-transporter BAA_1523 ENOG4105DFD Na H antiporter BAA_1527 ENOG4105ENE Histidine kinase BAA_1528 ENOG4105WH1 Two component transcriptional regulator luxr family BAA_1531 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BAA_1536 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BAA_1540 ENOG4105CJ3 phosphate transporter BAA_1541 ENOG4107GRR phosphate transport regulator BAA_1542 ENOG4105BZ4 penicillin-binding protein BAA_1547 ENOG4105I3N Conserved Protein BAA_1550 ENOG4105BZU Histidine kinase BAA_1557 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BAA_1558 ENOG4105DZ1 carboxypeptidase BAA_1559 ENOG4108JIC nucleoside recognition domain protein BAA_1561 ENOG4105FE9 pseudouridine synthase BAA_1563 ENOG4107TWT Cytochrome c biogenesis protein BAA_1564 ENOG4105CRE cytochrome C BAA_1565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAA_1566 ENOG4105BZU Histidine kinase BAA_1567 ENOG4108WBT adenosyltransferase BAA_1571 ENOG4108SAX Membrane BAA_1573 ENOG4105T7X BAA_1574 ENOG4105C9U ATP-dependent DNA helicase RecQ BAA_1575 ENOG4105I7S Abortive infection protein BAA_1579 ENOG4107X2D transcriptional regulator, merr family BAA_1580 ENOG4108S6Z Negative regulator of genetic competence BAA_1585 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BAA_1586 ENOG4105HDK L-asparaginase BAA_1592 ENOG4105S2F BAA_1593 ENOG41065D1 BAA_1599 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BAA_1602 ENOG4105XXQ heptaprenyl diphosphate synthase component I BAA_1604 ENOG4105EAH synthase BAA_1608 ENOG4105CIH Imidazole acetol-phosphate transaminase BAA_1609 ENOG41068YB TPR repeat-containing protein BAA_1612 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BAA_1613 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BAA_1614 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BAA_1620 ENOG4108JYZ YitT family BAA_1621 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BAA_1624 ENOG4105FJR Lmbe family BAA_1625 ENOG4105CPK Glycosyl transferase (Group 1 BAA_1632 ENOG4105DVT helicase BAA_1633 ENOG4105YAC BAA_1637 ENOG4105CSM endonuclease III BAA_1639 ENOG4105BZ4 penicillin-binding protein BAA_1651 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BAA_1653 ENOG4105DVT helicase BAA_1654 ENOG4105CTD carboxy-peptidase BAA_1657 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BAA_1661 ENOG4105C2W permease BAA_1662 ENOG4105DHF Membrane BAA_1664 ENOG410890F Dynamin family BAA_1666 ENOG4108W0I acetyltransferase BAA_1668 ENOG4105KHC sulfurtransferase BAA_1691 ENOG4108SZE gCN5-related N-acetyltransferase BAA_1695 ENOG41081VK Ribonuclease BAA_1709 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BAA_1711 ENOG4107RWR Sodium hydrogen exchanger BAA_1713 ENOG4108Z5V transcriptional regulator, merr family BAA_1715 ENOG4105H67 Protein of unknown function (DUF421) BAA_1717 ENOG41080C8 DUF218 domain BAA_1728 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BAA_1731 ENOG4105ER2 Ompa motb domain protein BAA_1732 ENOG4107YTP response regulator receiver protein BAA_1735 ENOG4105DD5 Flagellar motor switch protein BAA_1738 ENOG4105BZU Histidine kinase BAA_1742 ENOG4105E1Q flagellar hook-associated protein BAA_1748 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BAA_1749 ENOG4108ZC9 flagellar basal-body rod protein flgc BAA_1750 ENOG41075Z6 flagellar hook-basal body complex protein fliE BAA_1753 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BAA_1761 ENOG4105BZE flagellar hook protein, FlgE BAA_1780 ENOG4105I03 Flagellin BAA_1781 ENOG4105E4C Lytic transglycosylase catalytic BAA_1785 ENOG4105DD5 Flagellar motor switch protein BAA_1787 ENOG4105CN7 Flagellar biosynthetic protein FliP BAA_1788 ENOG4105VS8 Flagellar biosynthetic protein fliq BAA_1790 ENOG4105D00 flagellar biosynthetic protein flhB BAA_1791 ENOG4105D7B Flagellar biosynthesis protein flha BAA_1794 ENOG4105KTQ flagellar basal-body rod protein BAA_1795 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BAA_1800 ENOG4108RZE Tetr family transcriptional regulator BAA_1803 ENOG4105KAC Antibiotic biosynthesis monooxygenase BAA_1808 ENOG4105DUM transcriptional regulator, lysR family BAA_1810 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BAA_1811 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BAA_1812 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BAA_1819 ENOG4105CVJ phosphoglycerate mutase BAA_1826 ENOG4105CAQ asparagine synthetase BAA_1830 ENOG4105PGM cation diffusion facilitator family transporter BAA_1832 ENOG4105DRR Transcriptional regulator, GntR family BAA_1833 ENOG4108UZ3 Transporter BAA_1834 ENOG4105CKI cobalamin synthesis protein BAA_1835 ENOG4108PJD permease BAA_1839 ENOG4105DFD Na H antiporter BAA_1840 ENOG4105C9Q fumarate hydratase class II BAA_1846 ENOG4105EC3 peptidase S51, dipeptidase E BAA_1850 ENOG4107QIV Cytochrome c biogenesis protein BAA_1857 ENOG4106BRA Membrane BAA_1864 ENOG4105CJ1 ABC, transporter BAA_1868 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BAA_1870 ENOG4108IJ0 Aspartate ammonia-lyase BAA_1871 ENOG4105C6K Malic enzyme BAA_1885 ENOG4105FVX BAA_1898 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BAA_1901 ENOG4105EU0 Major facilitator Superfamily BAA_1902 ENOG4105C6T cysteine synthase BAA_1906 ENOG4105C8J )-transporter BAA_1908 ENOG4105X5K response regulator receiver protein BAA_1909 ENOG4105H67 Protein of unknown function (DUF421) BAA_1913 ENOG4106KE4 Dehydrogenase BAA_1916 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BAA_1917 ENOG4105CHR reductase BAA_1918 ENOG4105CM2 brancheD-chain amino acid aminotransferase BAA_1919 ENOG4105C7K acetolactate synthase BAA_1920 ENOG4108ZP8 Acetolactate synthase small subunit BAA_1921 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BAA_1923 ENOG4105C7B Threonine dehydratase BAA_1927 ENOG4105C6X Major Facilitator BAA_1928 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BAA_1930 ENOG4105DY9 regulatoR BAA_1931 ENOG4105CYC Transferase BAA_1935 ENOG4105F6J Alpha beta hydrolase fold BAA_1942 ENOG41068WN BAA_1947 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BAA_1948 ENOG4105C72 UPF0176 protein BAA_1950 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BAA_1959 ENOG4107RHR regulatoR BAA_1961 ENOG4105D9N nucleoside BAA_1962 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BAA_1969 ENOG4107RAQ aminopeptidase BAA_1970 ENOG4107STQ Multicopper oxidase BAA_1982 ENOG4108T5E Copper resistance protein BAA_1983 ENOG4105KTB nuclear export factor GLE1 BAA_1985 ENOG4107RT3 EamA-like transporter family BAA_1986 ENOG4105GZI Transcriptional regulator BAA_1987 ENOG4108Z40 Transcriptional regulator BAA_1988 ENOG4107ZXU DSBA oxidoreductase BAA_1989 ENOG4108TVJ Nitroreductase BAA_1991 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BAA_1992 ENOG4106F5Q Membrane BAA_1993 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BAA_1995 ENOG4105CKI cobalamin synthesis protein BAA_1999 ENOG4108Z7G MaoC domain protein dehydratase BAA_2000 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BAA_2002 ENOG4105C0Z ABC transporter BAA_2003 ENOG4108IV0 ABC, transporter BAA_2004 ENOG4105C32 Amino acid ABC transporter (Permease) BAA_2006 ENOG4105SKE transcriptional Regulator LysR family BAA_2010 ENOG4105YGB Transcriptional regulator BAA_2012 ENOG4105C4M (Ubiquinol oxidase) subunit I BAA_2013 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BAA_2014 ENOG4108JJ9 ABC, transporter BAA_2015 ENOG4108JJ8 (ABC) transporter BAA_2025 ENOG4105EFI regulatoR BAA_2026 ENOG4105BZU Histidine kinase BAA_2030 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BAA_2031 ENOG4108ZJ4 polysaccharide deacetylase BAA_2036 ENOG4105D6E homoserine dehydrogenase BAA_2041 ENOG4108KGH TRANSCRIPTIONal BAA_2043 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BAA_2044 ENOG4105BZU Histidine kinase BAA_2045 ENOG4107VMI polysaccharide deacetylase BAA_2047 ENOG4105KT7 mgtC SapB transporter BAA_2048 ENOG4105VRR gCN5-related N-acetyltransferase BAA_2050 ENOG4105DUU IucA IucC family protein BAA_2051 ENOG4105CEY Amp-dependent synthetase and ligase BAA_2054 ENOG4108WBH protein TIM barrel BAA_2055 ENOG4105YWU small acid-soluble spore protein BAA_2059 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BAA_2071 ENOG4105KRN Transcriptional regulator, abrb family BAA_2073 ENOG4105YVS arsR family transcriptional regulator BAA_2074 ENOG4107SET aldo keto reductase BAA_2075 ENOG4107XZQ multidrug resistance protein BAA_2080 ENOG4105C8Q Methyl-accepting chemotaxis BAA_2083 ENOG4108K88 Membrane BAA_2084 ENOG4108WPJ Ferritin-like domain BAA_2087 ENOG4105DEN Luciferase family BAA_2091 ENOG4107QM2 Aldo Keto reductase BAA_2092 ENOG4105CKI cobalamin synthesis protein BAA_2102 ENOG4105DSE periplasmic solute binding protein BAA_2104 ENOG4105K4T epimerase BAA_2106 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BAA_2111 ENOG4105CVJ phosphoglycerate mutase BAA_2115 ENOG4107T5V SNARE associated Golgi BAA_2118 ENOG4108PJD permease BAA_2120 ENOG4108S4H thioesterase Superfamily protein BAA_2126 ENOG4105SXS Protein of unknown function (DUF456) BAA_2127 ENOG4105C37 (CBS) domain BAA_2131 ENOG4108Z7R Chaperone CsaA BAA_2134 ENOG4108ZRV stage ii sporulation protein p BAA_2136 ENOG4108VXD carboxy-peptidase BAA_2138 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BAA_2143 ENOG4108X4Q Hydrolase BAA_2145 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BAA_2146 ENOG4107RBS Methyltransferase BAA_2149 ENOG41087PP glycosyltransferase MGT family BAA_2150 ENOG4108JYZ YitT family BAA_2151 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BAA_2158 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BAA_2167 ENOG4105KBJ sporulation protein ytfj BAA_2172 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BAA_2176 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BAA_2177 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BAA_2179 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BAA_2180 ENOG4105EMN RNA polymerase sigma factor BAA_2185 ENOG4108V06 Glutathione peroxidase BAA_2188 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BAA_2192 ENOG4108IUE nitrate reductase beta subunit BAA_2193 ENOG4105R3A Nitrate reductase BAA_2198 ENOG4107V6Q Cyclic nucleotide-binding domain BAA_2199 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BAA_2200 ENOG4105D06 uba thif-type nad fad binding protein BAA_2201 ENOG4105CVM Molybdenum cofactor synthesis domain protein BAA_2202 ENOG4108ZAF Molybdopterin BAA_2207 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BAA_2208 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BAA_2209 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BAA_2210 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BAA_2211 ENOG4108IFG nitrite reductase, (NAD(P)H) BAA_2212 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BAA_2219 ENOG4105MCT stage V sporulation protein S BAA_2226 ENOG4105C5H ABC transporter BAA_2229 ENOG4108UUM single-stranded DNA-binding protein BAA_2236 ENOG4107YX5 Pfam:DUF548 BAA_2237 ENOG4105C75 arginyL-tRNA synthetase BAA_2243 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BAA_2247 ENOG4105C5S asparaginyl-tRNA synthetase BAA_2251 ENOG4105EC2 ftsk spoIIIe BAA_2272 ENOG4105BZW Glycerate kinase BAA_2273 ENOG4107QPK )-transporter BAA_2274 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAA_2275 ENOG41062D9 Histidine kinase BAA_2278 ENOG4105C8J )-transporter BAA_2282 ENOG4107XGZ Hydrolase BAA_2283 ENOG4105CY2 Citrate transporter BAA_2284 ENOG4105C0A alcohol dehydrogenase BAA_2287 ENOG4105KD7 acetyltransferase BAA_2295 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BAA_2299 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BAA_2302 ENOG4107RVG penicillin-binding protein BAA_2303 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BAA_2304 ENOG4105E9Q Acyl-transferase BAA_2305 ENOG4108UT2 hemolysin iii BAA_2307 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BAA_2309 ENOG4108RCR degv family BAA_2310 ENOG4105E8R UPF0173 metal-dependent hydrolase BAA_2311 ENOG4108KF3 Electron transport protein SCO1 SenC BAA_2312 ENOG4107Y70 Heat shock protein BAA_2313 ENOG4105CAQ asparagine synthetase BAA_2317 ENOG4108MES Periplasmic binding protein BAA_2318 ENOG4105F0I Aminotransferase BAA_2325 ENOG4105D8X mechanosensitive ion channel BAA_2326 ENOG4105BZU Histidine kinase BAA_2327 ENOG4105WH1 Two component transcriptional regulator luxr family BAA_2344 ENOG4108IJ8 ABC transporter BAA_2345 ENOG4105E90 ABC transporter BAA_2352 ENOG4105C37 (CBS) domain BAA_2358 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BAA_2361 ENOG4107S4Y M20 DapE family protein YgeY BAA_2362 ENOG4108TSC N-acetyltransferase BAA_2363 ENOG4108JUB Transcriptional regulator BAA_2364 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BAA_2372 ENOG4108N23 SpoOM-related protein BAA_2374 ENOG410841Q phosphoesterase PA-phosphatase related protein BAA_2375 ENOG4105SZ6 Thioredoxin BAA_2378 ENOG4108IBT Inherit from COG: transposase BAA_2396 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BAA_2403 ENOG4105BZ4 penicillin-binding protein BAA_2404 ENOG4105CZM Major Facilitator BAA_2405 ENOG4105W8X HesB YadR YfhF-family protein BAA_2407 ENOG4105DXD 2-methylcitrate dehydratase BAA_2408 ENOG4105CR4 methylisocitrate lyase BAA_2410 ENOG4105C1G acyl-Coa dehydrogenase BAA_2411 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BAA_2413 ENOG4105N14 lysine exporter protein LysE YggA BAA_2414 ENOG4105E39 Enoyl-CoA hydratase BAA_2417 ENOG4107RFY SbcCD D subunit BAA_2418 ENOG4105EYH Exonuclease BAA_2425 ENOG4105FCD Major Facilitator BAA_2426 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BAA_2427 ENOG4105E4F Isochorismate synthase BAA_2428 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BAA_2429 ENOG4105WQI isochorismatase BAA_2430 ENOG4105CEY Amp-dependent synthetase and ligase BAA_2431 ENOG4105WQT MbtH domain protein BAA_2432 ENOG4105C0R drug resistance transporter emrb qaca subfamily BAA_2435 ENOG4105K70 DNA-binding protein BAA_2439 ENOG4105BZG amino acid carrier protein BAA_2444 ENOG4105FE9 pseudouridine synthase BAA_2446 ENOG4105C22 threonyL-tRNA synthetase BAA_2450 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BAA_2456 ENOG4108D32 Methyltransferase BAA_2462 ENOG41081I9 integral membrane protein BAA_2464 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BAA_2466 ENOG4105EYF MMPL domain protein BAA_2471 ENOG4105WCN acetyltransferase BAA_2477 ENOG4105C1Q protoporphyrinogen oxidase BAA_2479 ENOG41068WN BAA_2481 ENOG4105VEQ Cold shock protein BAA_2486 ENOG410667J hydrolase BAA_2493 ENOG4107V2S Transcriptional regulator BAA_2494 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BAA_2497 ENOG4105DND Transcriptional regulator BAA_2498 ENOG4108RPX mosc domain containing protein BAA_2501 ENOG4105BZ1 (ABC) transporter BAA_2502 ENOG4105BZ1 (ABC) transporter BAA_2505 ENOG4108JCI Transcriptional regulator BAA_2511 ENOG4108KPJ rna polymerase sigma factor BAA_2523 ENOG4105RD7 BadF BadG BcrA BcrD BAA_2525 ENOG4107STF Involved in phosphonate degradation (By similarity) BAA_2528 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BAA_2531 ENOG4105C1J atp-dependent rna helicase BAA_2535 ENOG4108RZE Tetr family transcriptional regulator BAA_2539 ENOG41088CC tellurite resistance protein tehB BAA_2541 ENOG4108I0C methyltransferase BAA_2542 ENOG4107RA9 decarboxylase BAA_2543 ENOG41090HR transcriptional regulator BAA_2553 ENOG4105CIN aminoacyl-histidine dipeptidase BAA_2559 ENOG4107RF6 penicillin-binding protein BAA_2564 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BAA_2565 ENOG4105ETE Transcriptional regulator (LacI family BAA_2566 ENOG4105IE8 Alpha-ketoglutarate permease BAA_2567 ENOG4105CK5 oxidoreductase BAA_2574 ENOG4105D2N Aldolase BAA_2575 ENOG4105DH8 myo-inositol catabolism BAA_2583 ENOG4105VZ8 Transcriptional regulator BAA_2585 ENOG4108VXD carboxy-peptidase BAA_2590 ENOG41067SE Tetr family transcriptional regulator BAA_2591 ENOG4105C5H ABC transporter BAA_2593 ENOG4105BZU Histidine kinase BAA_2596 ENOG4106ANW SMI1_KNR4 BAA_2597 ENOG4105CEP NADH dehydrogenase BAA_2598 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BAA_2601 ENOG4105CJ1 ABC, transporter BAA_2603 ENOG4107Z3H Transcriptional regulator, TetR family BAA_2606 ENOG4105C1G acyl-Coa dehydrogenase BAA_2607 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BAA_2608 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BAA_2609 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BAA_2610 ENOG4105E39 Enoyl-CoA hydratase BAA_2611 ENOG4107QX3 carboxylase BAA_2612 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BAA_2614 ENOG4105WCN acetyltransferase BAA_2615 ENOG4105DBI uridine monophosphokinase BAA_2618 ENOG4105DZ1 carboxypeptidase BAA_2621 ENOG4105T9C HD domain BAA_2623 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BAA_2632 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BAA_2632 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BAA_2635 ENOG4105FQP Beta-lactamase BAA_2637 ENOG4107Y80 Major Facilitator superfamily BAA_2641 ENOG4105CUV Homoserine Kinase BAA_2648 ENOG4105CPQ Dehydrogenase BAA_2675 ENOG4105ETU transcriptional activator (TenA BAA_2700 ENOG410667J hydrolase BAA_2703 ENOG4107RF6 penicillin-binding protein BAA_2708 ENOG4108JJB ABC transporter BAA_2711 ENOG4108HGU Histidine kinase BAA_2714 ENOG4105CB2 alcohol dehydrogenase BAA_2715 ENOG4105CJN penicillin-binding protein BAA_2717 ENOG4105FQP Beta-lactamase BAA_2723 ENOG4108V4B ThiJ pfpI BAA_2728 ENOG4107Y80 Major Facilitator superfamily BAA_2731 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BAA_2736 ENOG4107Y9U Membrane BAA_2744 ENOG4105FCD Major Facilitator BAA_2747 ENOG4105E09 nadh pyrophosphatase BAA_2748 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BAA_2749 ENOG4108Z4K mutator MutT protein BAA_2756 ENOG4108XI2 Domain of unknown function (DUF1963) BAA_2762 ENOG4105KWG Pfam:DUF1696 BAA_2770 ENOG4105PKS Excinuclease abc c subunit domain protein BAA_2779 ENOG4107VFR oxidoreductase BAA_2784 ENOG4105PAD Hydrolase BAA_2789 ENOG4105DY8 decarboxylase BAA_2793 ENOG4108IUM Glycogen debranching enzyme BAA_2798 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BAA_2800 ENOG4105FDR Membrane BAA_2807 ENOG4108V3A UPF0421 protein BAA_2811 ENOG4105MSI germination protein ypeb BAA_2815 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BAA_2816 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BAA_2817 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BAA_2818 ENOG4107Z3H Transcriptional regulator, TetR family BAA_2824 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BAA_2828 ENOG4105E98 transcriptional regulator DeoR family BAA_2832 ENOG41062ES Transcriptional regulator BAA_2837 ENOG4107QKR Dehydrogenase BAA_2839 ENOG4107RUY (E1 component), alpha subunit BAA_2842 ENOG4105E1F short-chain dehydrogenase reductase BAA_2843 ENOG4105RHY Pfam:UPF0157 BAA_2848 ENOG4107SQ8 Glycine betaine BAA_2849 ENOG4108IJ7 Glycine betaine BAA_2854 ENOG4105E66 phosphoriboisomerase A BAA_2855 ENOG41082BV acetyltransferase BAA_2856 ENOG4108M1A Chitin-binding protein BAA_2866 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BAA_2877 ENOG4105EEM helicase BAA_2881 ENOG4105C9U ATP-dependent DNA helicase RecQ BAA_2889 ENOG4108M1A Chitin-binding protein BAA_2892 ENOG4105BZG amino acid carrier protein BAA_2893 ENOG4105C26 Dehydrogenase BAA_2894 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BAA_2895 ENOG4105CTU Proline racemase BAA_2896 ENOG4105CTU Proline racemase BAA_2897 ENOG41080HI glycine oxidase BAA_2905 ENOG4107T5V SNARE associated Golgi BAA_2908 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BAA_2909 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BAA_2912 ENOG4105DTQ mandelate racemase muconate lactonizing BAA_2920 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BAA_2921 ENOG4105BZU Histidine kinase BAA_2932 ENOG4105EPR degv family BAA_2940 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BAA_2941 ENOG4106K7D Major facilitator family transporter BAA_2946 ENOG4107BMA Transglycosylase associated protein BAA_2955 ENOG4105CHM Aminotransferase BAA_2971 ENOG4105C02 permease BAA_2973 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BAA_2974 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BAA_2975 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BAA_2980 ENOG4105E09 nadh pyrophosphatase BAA_2984 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BAA_2994 ENOG4107VC0 DNA alkylation repair enzyme BAA_2997 ENOG4107VMI polysaccharide deacetylase BAA_2999 ENOG4108ZCF integral membrane protein BAA_3000 ENOG4105E0M Sulfatase BAA_3001 ENOG4105C5H ABC transporter BAA_3006 ENOG41082JN Transcriptional regulator BAA_3010 ENOG4105CIH Imidazole acetol-phosphate transaminase BAA_3011 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BAA_3012 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BAA_3020 ENOG41069ER domain protein BAA_3022 ENOG4105EMN RNA polymerase sigma factor BAA_3027 ENOG4105D4B ABC, transporter BAA_3029 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BAA_3032 ENOG4105DKT Transcriptional regulator BAA_3036 ENOG41061GT Aldolase BAA_3041 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BAA_3047 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BAA_3048 ENOG4105II7 pyrroline-5-carboxylate reductase BAA_3050 ENOG4107258 Transcriptional regulator BAA_3052 ENOG4105E0Y RtcB Protein BAA_3054 ENOG4105G6Z alkaline phosphatase BAA_3056 ENOG4105VMP Transcriptional regulator BAA_3059 ENOG41090T1 Membrane BAA_3061 ENOG4108WCX response regulator BAA_3063 ENOG41068WN BAA_3068 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BAA_3072 ENOG4105CKK Glycosyl transferase, family 2 BAA_3076 ENOG4105CKK Glycosyl transferase, family 2 BAA_3079 ENOG4105C8Y Acetylornithine aminotransferase BAA_3088 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BAA_3090 ENOG4108TVJ Nitroreductase BAA_3091 ENOG4105FS7 Transcriptional regulator BAA_3100 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BAA_3102 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BAA_3108 ENOG4108XET gCN5-related N-acetyltransferase BAA_3124 ENOG410635A Membrane BAA_3125 ENOG4105KNA -acetyltransferase BAA_3127 ENOG4108IQI permease BAA_3129 ENOG4105F1N DNA alkylation repair BAA_3140 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BAA_3148 ENOG4105P4J Allophanate hydrolase, subunit 1 BAA_3149 ENOG4107258 Transcriptional regulator BAA_3151 ENOG4106N3A copper homeostasis protein cutc BAA_3152 ENOG4108ZRV stage ii sporulation protein p BAA_3153 ENOG4108ZHR arsR family transcriptional regulator BAA_3155 ENOG4105FDT acyl-CoA dehydrogenase BAA_3159 ENOG4105DWD nucleoside recognition domain protein BAA_3165 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BAA_3180 ENOG4105E2A Dehydrogenase BAA_3183 ENOG4108IJ0 Aspartate ammonia-lyase BAA_3184 ENOG4105HDK L-asparaginase BAA_3185 ENOG4108IMY Transcriptional regulator BAA_3187 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BAA_3188 ENOG4105CUB amino acid BAA_3190 ENOG4105II7 pyrroline-5-carboxylate reductase BAA_3192 ENOG4105C6K Malic enzyme BAA_3205 ENOG4105CSV Glutaminase BAA_3213 ENOG4105CGH 5'-nucleotidase BAA_3214 ENOG4105CH6 catalase BAA_3216 ENOG4105CHJ isochorismatase hydrolase BAA_3229 ENOG4108606 TspO/MBR family BAA_3230 ENOG4105CVP deoxyribo-dipyrimidine photolyase BAA_3233 ENOG4108TWJ NADH dehydrogenase subunit 5 BAA_3234 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BAA_3236 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BAA_3237 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BAA_3238 ENOG4105DSE periplasmic solute binding protein BAA_3239 ENOG4105CC5 ABC transporter BAA_3240 ENOG4105DIK (ABC) transporter BAA_3246 ENOG4105D6J arsenicaL-resistance protein BAA_3247 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BAA_3248 ENOG41085FC arsR family transcriptional regulator BAA_3251 ENOG4105F7F Chaperone BAA_3253 ENOG4105CHR reductase BAA_3254 ENOG4108YXU transcriptional regulator AsnC family BAA_3269 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BAA_3271 ENOG4105C0R drug resistance transporter emrb qaca subfamily BAA_3273 ENOG4105IIP Membrane BAA_3276 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAA_3277 ENOG41062D9 Histidine kinase BAA_3282 ENOG4105K6H D-cysteine desulfhydrase BAA_3288 ENOG4105VZ8 Transcriptional regulator BAA_3291 ENOG4108NNI Beta-lactamase domain-containing protein BAA_3292 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BAA_3294 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BAA_3295 ENOG4105JQZ Methyltransferase BAA_3298 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BAA_3299 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BAA_3302 ENOG4105BZU Histidine kinase BAA_3305 ENOG4108U05 Transcriptional regulator BAA_3309 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BAA_3310 ENOG4105DJB Major Facilitator Superfamily BAA_3311 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BAA_3312 ENOG4107QR9 Iron-sulfur cluster binding protein BAA_3314 ENOG4106P55 Transcriptional regulator BAA_3316 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BAA_3321 ENOG4105TRI Hydrolase BAA_3329 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BAA_3336 ENOG4107QJQ Mate efflux family protein BAA_3340 ENOG4105EQ0 Major Facilitator superfamily BAA_3341 ENOG4108JGH Tetr family transcriptional regulator BAA_3343 ENOG4105C44 Serine transporter BAA_3344 ENOG4105EJQ L-serine dehydratase BAA_3347 ENOG4108JPW Aminotransferase BAA_3350 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BAA_3352 ENOG4105DVH amino acid BAA_3355 ENOG4108JQ1 Dehydrogenase BAA_3359 ENOG4108AEY RNA polymerase sigma factor BAA_3362 ENOG41082W1 Cupin 2, conserved barrel domain protein BAA_3363 ENOG410874W AraC family transcriptional regulator BAA_3375 ENOG4108ISG Major Facilitator BAA_3377 ENOG4107MII Sugar-specific transcriptional regulator TrmB BAA_3378 ENOG4105CZM Major Facilitator BAA_3382 ENOG4105DA5 (ABC) transporter BAA_3383 ENOG41069JR BAA_3386 ENOG4105RXJ BAA_3387 ENOG4105KPY Small multidrug resistance protein BAA_3388 ENOG4105KBX Transcriptional regulator, TetR family BAA_3390 ENOG4105CRW Short chain fatty acid transporter BAA_3392 ENOG4105DYS nad(p)h dehydrogenase (quinone) BAA_3399 ENOG4108JJB ABC transporter BAA_3400 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BAA_3405 ENOG4108K8S endonuclease I BAA_3408 ENOG41067QW Transcriptional regulator BAA_3410 ENOG4108Z66 YbaK ebsC protein BAA_3411 ENOG4105CUT histidyl-tRNA synthetase BAA_3414 ENOG4105KVH Transcriptional regulator BAA_3415 ENOG4108RCM Nitroreductase BAA_3419 ENOG4108PSK reductase BAA_3421 ENOG4105CJ1 ABC, transporter BAA_3433 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BAA_3434 ENOG4105DKQ ROK family BAA_3435 ENOG4106UW1 Major Facilitator superfamily BAA_3436 ENOG4108UW5 maltose o-acetyltransferase BAA_3439 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BAA_3441 ENOG4105C31 Tryptophanyl-tRNA synthetase BAA_3442 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BAA_3448 ENOG4105DMQ Methyltransferase BAA_3450 ENOG4105EV4 Multidrug resistance protein mdtH BAA_3456 ENOG4105C37 (CBS) domain BAA_3459 ENOG4105DDN Pentapeptide repeat-containing protein BAA_3460 ENOG4105XDF Protein of unknown function (DUF1272) BAA_3461 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BAA_3462 ENOG4105CMG Carbohydrate kinase BAA_3463 ENOG4105C6Z Gluconate BAA_3464 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BAA_3467 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BAA_3468 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BAA_3469 ENOG4105CIS alcohol dehydrogenase BAA_3470 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BAA_3473 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BAA_3474 ENOG4105D4Y metalloprotease BAA_3478 ENOG4105CV8 reductase BAA_3479 ENOG4105F27 Major Facilitator BAA_3482 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BAA_3483 ENOG4105C44 Serine transporter BAA_3489 ENOG4105KVH Transcriptional regulator BAA_3490 ENOG4108TZY GntR Family Transcriptional Regulator BAA_3493 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BAA_3494 ENOG4105KVH Transcriptional regulator BAA_3495 ENOG4105KVH Transcriptional regulator BAA_3502 ENOG4105JAB phenazine biosynthesis protein, phzf family BAA_3504 ENOG4105CHR reductase BAA_3509 ENOG4105KVH Transcriptional regulator BAA_3525 ENOG4105KAF membrAne BAA_3530 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BAA_3533 ENOG4107YXZ hydrolase, family 25 BAA_3538 ENOG4105ED2 Beta-lactamase BAA_3540 ENOG4105H3G oxidoreductase BAA_3556 ENOG4108TN2 lmbE family BAA_3558 ENOG4107R3E Citrate transporter BAA_3565 ENOG4105EHG Permease protein BAA_3566 ENOG4105DQ5 transport system permease protein BAA_3567 ENOG4105NX3 Membrane BAA_3568 ENOG4107ZY0 Phenazine biosynthesis-like protein BAA_3572 ENOG4107CUJ Protein of unknown function (DUF2690) BAA_3574 ENOG4107V2S Transcriptional regulator BAA_3578 ENOG4105C98 muts2 protein BAA_3581 ENOG4105E5K Alpha-amylase BAA_3583 ENOG4105DPN Oligoendopeptidase f BAA_3584 ENOG4108A04 Beta-lactamase BAA_3590 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BAA_3594 ENOG41082BM Transcriptional regulator, arsr family BAA_3595 ENOG4105CIS alcohol dehydrogenase BAA_3601 ENOG4105RHY Pfam:UPF0157 BAA_3603 ENOG4105C09 Bile acid BAA_3604 ENOG4105CQB FAD linked oxidase domain protein BAA_3608 ENOG4108UT6 Transferase hexapeptide repeat containing protein BAA_3610 ENOG4105K64 Glycosyl transferase, family 2 BAA_3611 ENOG4105E39 Enoyl-CoA hydratase BAA_3613 ENOG4105KT7 mgtC SapB transporter BAA_3616 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BAA_3617 ENOG41073R8 VanW family BAA_3619 ENOG4108R1P BAA_3623 ENOG4105VEQ Cold shock protein BAA_3627 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BAA_3631 ENOG410904N short-chain dehydrogenase reductase BAA_3633 ENOG4106IQC argininosuccinate lyase BAA_3636 ENOG4108IA2 Sodium pantothenate symporter BAA_3638 ENOG4105C26 Dehydrogenase BAA_3639 ENOG4105CHR reductase BAA_3641 ENOG4105EWU Squalene--hopene cyclase BAA_3643 ENOG4105FR1 rard protein BAA_3644 ENOG410696E Membrane BAA_3647 ENOG4105D1F ATP-binding protein BAA_3649 ENOG4108ZAF Molybdopterin BAA_3650 ENOG4105CVM Molybdenum cofactor synthesis domain protein BAA_3651 ENOG4105D06 uba thif-type nad fad binding protein BAA_3652 ENOG4105TMB Formate nitrite transporter BAA_3654 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BAA_3655 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BAA_3657 ENOG4108JB9 formate dehydrogenase BAA_3659 ENOG4105E1K spore germination protein BAA_3675 ENOG4108KGH TRANSCRIPTIONal BAA_3677 ENOG4105EMN RNA polymerase sigma factor BAA_3682 ENOG4105CIG ABC transporter BAA_3684 ENOG4105D9R oxidoreductase BAA_3686 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BAA_3687 ENOG4105K4P CoA-binding domain protein BAA_3688 ENOG4105C0H protease BAA_3689 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAA_3692 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BAA_3693 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BAA_3694 ENOG4105W8X HesB YadR YfhF-family protein BAA_3700 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BAA_3701 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BAA_3704 ENOG4108JJA ABC, transporter BAA_3705 ENOG4108I0Z Aconitate hydratase BAA_3710 ENOG4105E5W Transporter BAA_3712 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BAA_3716 ENOG4107F3J Amp-dependent synthetase and ligase BAA_3717 ENOG4107ZYJ bioY protein BAA_3718 ENOG4105CEY Amp-dependent synthetase and ligase BAA_3727 ENOG4107AYK membrAne BAA_3729 ENOG4105BZU Histidine kinase BAA_3730 ENOG4105FBA Phospholipase Carboxylesterase BAA_3731 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BAA_3732 ENOG4105CK7 Sodium proline symporter BAA_3733 ENOG4105CBC glutamate synthase BAA_3734 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BAA_3735 ENOG4108VJ1 Transcriptional regulator (CarD family BAA_3736 ENOG4108903 Formimidoylglutamase BAA_3741 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BAA_3752 ENOG4107QIV Cytochrome c biogenesis protein BAA_3754 ENOG4107RSM transcriptional regulator BAA_3755 ENOG4105VAW lrga family BAA_3756 ENOG41067MG lrgb family BAA_3762 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BAA_3765 ENOG4105BZ1 (ABC) transporter BAA_3766 ENOG4105BZ1 (ABC) transporter BAA_3770 ENOG4105D7V transposase BAA_3773 ENOG4105D5T phosphonate abc transporter BAA_3778 ENOG4108SVB resolvase BAA_3782 ENOG4105K7K Transcriptional regulator BAA_3792 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BAA_3793 ENOG4105XSJ toxin secretion phage lysis holin BAA_3835 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BAA_3856 ENOG4105C5F glutamine synthetase BAA_3857 ENOG4105KV4 Transcriptional regulator BAA_3858 ENOG4105CXI aluminum resistance protein BAA_3861 ENOG4105EN6 Membrane BAA_3862 ENOG4106F1P AAA ATPase, central domain protein BAA_3868 ENOG41069ER domain protein BAA_3869 ENOG4105DM4 PTS System BAA_3870 ENOG4105DE4 1-phosphofructokinase BAA_3871 ENOG4105E98 transcriptional regulator DeoR family BAA_3874 ENOG4108SJC Membrane BAA_3877 ENOG4105C85 amino acid BAA_3881 ENOG4105TMB Formate nitrite transporter BAA_3882 ENOG4105K70 DNA-binding protein BAA_3883 ENOG4105C59 p-type ATPase BAA_3885 ENOG4105VPX protein, conserved in bacteria BAA_3887 ENOG4105NIV Esterase BAA_3888 ENOG4105E0A ABC, transporter BAA_3893 ENOG4105CGK Exodeoxyribonuclease III BAA_3895 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BAA_3896 ENOG4105D03 DNA-3-methyladenine glycosylase II BAA_3903 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BAA_3905 ENOG4105BZU Histidine kinase BAA_3909 ENOG41067MG lrgb family BAA_3912 ENOG4107TTQ Alpha beta hydrolase fold BAA_3913 ENOG4107YEI lmbE family BAA_3918 ENOG4105F0V Cell wall hydrolase BAA_3919 ENOG4107R6R udp-galactopyranose mutase BAA_3920 ENOG4105E0M Sulfatase BAA_3921 ENOG410890F Dynamin family BAA_3923 ENOG4107QHE Choloylglycine hydrolase BAA_3928 ENOG4105DA5 (ABC) transporter BAA_3933 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BAA_3934 ENOG4105DQU oxidoreductase, subunit beta BAA_3935 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BAA_3936 ENOG4108IGT Dipeptidase BAA_3937 ENOG4105MCT stage V sporulation protein S BAA_3938 ENOG4105D48 metallophosphoesterase BAA_3943 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BAA_3946 ENOG4105XZV Protein of unknown function (DUF3243) BAA_3947 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BAA_3953 ENOG4108JQ9 ABC transporter BAA_3954 ENOG4105DIH basic membrane BAA_3955 ENOG4105FDP GntR family transcriptional regulator BAA_3957 ENOG4107QZI cell division protein FtsK BAA_3959 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BAA_3961 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BAA_3963 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BAA_3964 ENOG4108S0H Dipicolinic acid synthetase, b subunit BAA_3965 ENOG4105E35 Dipicolinate synthase subunit A BAA_3967 ENOG4105C1V Peptidase, M16 BAA_3970 ENOG4105DTN riboflavin biosynthesis protein ribF BAA_3971 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BAA_3973 ENOG4105W7A Protein of unknown function (DUF503) BAA_3975 ENOG4105VHM ribosomal protein BAA_3976 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BAA_3977 ENOG4105CHV Transcription elongation factor NusA BAA_3979 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BAA_3981 ENOG4105DZP Membrane-associated zinc metalloprotease BAA_3982 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BAA_3983 ENOG4105KNE Phosphatidate cytidylyltransferase BAA_3984 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BAA_3992 ENOG4108HE4 integrase family BAA_3994 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BAA_3996 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BAA_3999 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BAA_4005 ENOG4105VB6 UPF0109 protein BAA_4009 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BAA_4010 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BAA_4013 ENOG4105CHR reductase BAA_4014 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BAA_4017 ENOG4105CB5 ATP-dependent DNA helicase recG BAA_4018 ENOG4105DP4 dak2 domain fusion protein ylov BAA_4019 ENOG4108ZAA Alkaline-shock protein BAA_4021 ENOG4105FJ0 thiamine BAA_4022 ENOG4105DJV ribulose-phosphate 3-epimerase BAA_4023 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BAA_4024 ENOG4105D9P serine threonine protein kinase BAA_4025 ENOG4108ZF3 Phosphatase BAA_4027 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BAA_4029 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BAA_4030 ENOG4105C25 Primosomal protein n' BAA_4031 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BAA_4035 ENOG4105DSJ YicC domain protein BAA_4037 ENOG4105F23 Fibronectin-binding protein BAA_4038 ENOG4105DC7 peptidase M24 BAA_4049 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BAA_4057 ENOG4105C34 Pseudouridine synthase BAA_4060 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BAA_4062 ENOG4105DBK s4 domain protein BAA_4063 ENOG41067XK integral membrane protein BAA_4065 ENOG4105DFA alanine racemase domain protein BAA_4066 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BAA_4067 ENOG4105WR5 sporulation protein, YlmC YmxH family BAA_4069 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BAA_4071 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BAA_4072 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BAA_4073 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BAA_4074 ENOG4105D4A Cell wall formation (By similarity) BAA_4075 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BAA_4076 ENOG4105CNI cell division protein FtsW BAA_4079 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BAA_4080 ENOG4105CJN penicillin-binding protein BAA_4081 ENOG4105CJN penicillin-binding protein BAA_4082 ENOG41068DC Essential cell division protein (By similarity) BAA_4089 ENOG4105KNH Nucleic acid-binding protein BAA_4099 ENOG4105XSJ toxin secretion phage lysis holin BAA_4117 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BAA_4119 ENOG4105CAR Terminase, large subunit BAA_4136 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BAA_4139 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BAA_4150 ENOG4108IMY Transcriptional regulator BAA_4157 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BAA_4159 ENOG41063PX domain protein BAA_4160 ENOG4105D78 K07001 NTE family protein BAA_4162 ENOG4105H20 Sporulation integral membrane protein YlbJ BAA_4163 ENOG4106H78 methyltransferase BAA_4169 ENOG4107TB6 phosphoglycerate mutase BAA_4172 ENOG4106UY4 Inherit from COG: Scp-like extracellular BAA_4182 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BAA_4183 ENOG4105CNI cell division protein FtsW BAA_4186 ENOG4108IAB Phoh family BAA_4190 ENOG4105QA2 BAA_4191 ENOG4105CI3 gtp-binding protein typa BAA_4193 ENOG4105ECY inositol monophosphatase BAA_4197 ENOG4105CXN decarboxylase BAA_4205 ENOG4105C7S Dehydrogenase BAA_4206 ENOG4105CPP Dehydrogenase, E1 component BAA_4209 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BAA_4210 ENOG4108X4Q Hydrolase BAA_4212 ENOG4105CN5 Metallo-Beta-Lactamase BAA_4213 ENOG4107ZYR domain protein BAA_4220 ENOG4108XRC Protein of unknown function (DUF458) BAA_4222 ENOG4107IN1 Protein of unknown function (DUF1797) BAA_4226 ENOG4105EPM Diguanylate phosphodiesterase BAA_4227 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BAA_4230 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BAA_4232 ENOG4105UIN BAA_4245 ENOG4108HGU Histidine kinase BAA_4247 ENOG4105CHM Aminotransferase BAA_4248 ENOG4105FKQ transcriptional regulator BAA_4250 ENOG4105EG2 ABC transporter, permease BAA_4252 ENOG4107FKK extracellular solute-binding protein family 1 BAA_4254 ENOG4105CG3 alpha amylase, catalytic region BAA_4262 ENOG4105CHU acetyl-coa acetyltransferase BAA_4269 ENOG4105K7K Transcriptional regulator BAA_4270 ENOG4105DTD Dehydrogenase BAA_4272 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BAA_4275 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BAA_4281 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BAA_4286 ENOG4106TD9 Diguanylate cyclase BAA_4290 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BAA_4293 ENOG4105CID antiterminator BAA_4295 ENOG4105FDP GntR family transcriptional regulator BAA_4297 ENOG4105CE4 GlcNAc 6-P deacetylase BAA_4304 ENOG4107ZE5 PPIases accelerate the folding of proteins BAA_4305 ENOG4105PTM secreted protein BAA_4306 ENOG4105J7I hydrolase BAA_4308 ENOG4105G6R Stage v sporulation protein ae BAA_4310 ENOG4105CZ3 stage V sporulation protein ad BAA_4311 ENOG41090VF Stage v sporulation protein ac BAA_4315 ENOG4105C8J )-transporter BAA_4316 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BAA_4318 ENOG41082AN stage II sporulation protein BAA_4319 ENOG4105DZ1 carboxypeptidase BAA_4320 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BAA_4321 ENOG4105DVE abc transporter atp-binding protein BAA_4327 ENOG4105D7N magnesium and cobalt transport protein CorA BAA_4332 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BAA_4334 ENOG4105I3K Ferric uptake regulator, Fur family BAA_4335 ENOG4105MZ9 stage II sporulation protein m BAA_4339 ENOG4105CPC Aldo Keto reductase BAA_4341 ENOG4105RHY Pfam:UPF0157 BAA_4345 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BAA_4347 ENOG4105ETE Transcriptional regulator (LacI family BAA_4348 ENOG4108YM7 Gcn5-related n-acetyltransferase BAA_4353 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BAA_4354 ENOG4108R6K riboflavin synthase, subunit alpha BAA_4358 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BAA_4359 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BAA_4360 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BAA_4361 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BAA_4363 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BAA_4366 ENOG4105DFD Na H antiporter BAA_4367 ENOG4105CGH 5'-nucleotidase BAA_4375 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BAA_4378 ENOG4108IXY short-chain dehydrogenase reductase BAA_4381 ENOG4105II7 pyrroline-5-carboxylate reductase BAA_4382 ENOG4105EJQ L-serine dehydratase BAA_4387 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BAA_4388 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BAA_4389 ENOG4105D9U N-acetyltransferase BAA_4391 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BAA_4392 ENOG4108QEG Membrane BAA_4393 ENOG4105CDA abc transporter atp-binding protein BAA_4394 ENOG4105E5Q amino acid AbC transporter BAA_4395 ENOG4108HW3 (ABC) transporter BAA_4398 ENOG4105G7B Protein of unknown function (DUF2992) BAA_4401 ENOG4105C7S Dehydrogenase BAA_4402 ENOG4105CPP Dehydrogenase, E1 component BAA_4406 ENOG4107RDP Dehydrogenase BAA_4408 ENOG4108JUB Transcriptional regulator BAA_4410 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BAA_4413 ENOG4107QQR Sporulation BAA_4414 ENOG4105S1Z Stage IV sporulation protein B BAA_4415 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BAA_4417 ENOG4105DX0 Hemolysin A BAA_4419 ENOG4105CTB Polyprenyl synthetase BAA_4424 ENOG4108ZSR alkaline shock protein BAA_4425 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BAA_4429 ENOG410644B Stage III sporulation protein af BAA_4431 ENOG4105KQ4 Stage iii sporulation protein ad BAA_4432 ENOG4108CQH stage III sporulation protein AC BAA_4433 ENOG4105KR5 Stage iii sporulation protein BAA_4434 ENOG4105CD2 stage iii sporulation protein aa BAA_4438 ENOG4105DC7 peptidase M24 BAA_4441 ENOG4105CBJ Metal-dependent enzyme BAA_4442 ENOG4107YBY Hydrolase BAA_4448 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BAA_4449 ENOG4105WZW rhodanese family BAA_4453 ENOG41080TC multidrug resistance protein BAA_4461 ENOG4105CJ1 ABC, transporter BAA_4462 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BAA_4468 ENOG4105C0D helicase BAA_4494 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BAA_4495 ENOG4105C3R Methionine synthase BAA_4499 ENOG4105C28 cystathionine BAA_4500 ENOG4105C28 cystathionine BAA_4504 ENOG4105C5X domain protein BAA_4506 ENOG4105DKQ ROK family BAA_4508 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BAA_4511 ENOG4108UTW Plays a role in the regulation of phosphate uptake BAA_4512 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BAA_4513 ENOG4105E2Z phosphate ABC transporter (Permease BAA_4514 ENOG4105C8U phosphate abc transporter BAA_4515 ENOG4105PWN phosphate abc transporter BAA_4516 ENOG4107RF6 penicillin-binding protein BAA_4518 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BAA_4523 ENOG4105N80 Ferric uptake regulator, Fur family BAA_4525 ENOG4105FDK ABC transporter BAA_4526 ENOG4108JYZ YitT family BAA_4527 ENOG41069ZM Protein of unknown function (DUF2624) BAA_4533 ENOG4105EGD dinuclear metal center protein, YbgI family BAA_4536 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BAA_4537 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BAA_4544 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BAA_4545 ENOG4105KG3 cytidine deaminase BAA_4546 ENOG4107YR5 Diacylglycerol kinase BAA_4548 ENOG4105CTJ Metal Dependent Phosphohydrolase BAA_4549 ENOG4105C9A Phoh family BAA_4551 ENOG41068P3 sporulation protein YqfC BAA_4552 ENOG4105KTH gatB Yqey BAA_4554 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BAA_4555 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BAA_4559 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BAA_4561 ENOG4105CSA Coproporphyrinogen iii oxidase BAA_4562 ENOG4105KVH Transcriptional regulator BAA_4567 ENOG4105TQK DNA polymerase iii, delta' subunit BAA_4569 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BAA_4571 ENOG4108UK2 deaminase BAA_4572 ENOG4105KQC Competence protein BAA_4574 ENOG4105DXX methyltransferase BAA_4576 ENOG4108WF2 Metal Dependent Phosphohydrolase BAA_4578 ENOG410812S Rna-binding protein BAA_4580 ENOG4105CQW ribosome biogenesis GTPase YqeH BAA_4581 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BAA_4584 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BAA_4589 ENOG4108TVJ Nitroreductase BAA_4593 ENOG4105G6Z alkaline phosphatase BAA_4596 ENOG4108MUZ hydrolase BAA_4603 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BAA_4605 ENOG4105MIR Phenylalanine 4-monooxygenase BAA_4616 ENOG4105S6R Iron-hydroxamate transporter permease subunit BAA_4617 ENOG4108V5C ABC transporter BAA_4619 ENOG4108EKI Dehydrogenase BAA_4620 ENOG4105C28 cystathionine BAA_4626 ENOG4107XRG penicillin-binding protein BAA_4629 ENOG4105CFP Peptidase U32 BAA_4630 ENOG4105XYU peptidase (U32 family) BAA_4631 ENOG4108VQJ O-methyltransferase BAA_4632 ENOG4105HHA aminodeoxychorismate lyase BAA_4636 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BAA_4638 ENOG4105C02 permease BAA_4641 ENOG41060CR BAA_4642 ENOG4105C7H Helicase, RecD TraA family BAA_4644 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BAA_4645 ENOG4105C3J Cysteine desulfurase BAA_4647 ENOG4105D1H recombination factor protein RarA BAA_4648 ENOG4108VCI transcription factor, rsfa family BAA_4649 ENOG4105CUZ uba thif-type nad fad binding protein BAA_4651 ENOG4105CUT histidyl-tRNA synthetase BAA_4654 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BAA_4656 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BAA_4657 ENOG41076HS cation diffusion facilitator family transporter BAA_4658 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BAA_4660 ENOG4105CKP Polysaccharide Biosynthesis Protein BAA_4661 ENOG4108QG2 Membrane BAA_4663 ENOG4105VIE preprotein translocase, subunit YajC BAA_4666 ENOG41061AI Protein of unknown function (DUF2905) BAA_4669 ENOG4108HUF Transporter BAA_4673 ENOG41082BM Transcriptional regulator, arsr family BAA_4678 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BAA_4679 ENOG4108IYU L-aspartate oxidase BAA_4682 ENOG4108RPX mosc domain containing protein BAA_4683 ENOG4105CQC Prephenate dehydratase BAA_4690 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BAA_4693 ENOG4105X36 (ribosomal) protein BAA_4696 ENOG4105C03 ribonuclease BAA_4699 ENOG4107QMS site-determining protein BAA_4702 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BAA_4703 ENOG4105DFF Rod shape-determining protein mreb BAA_4707 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BAA_4708 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BAA_4710 ENOG41068KH stage VI sporulation protein D BAA_4712 ENOG4105D52 delta-aminolevulinic acid dehydratase BAA_4717 ENOG4105K56 Transcriptional regulator BAA_4721 ENOG4108IUQ atp-dependent protease BAA_4726 ENOG4108QCI YvbH-like oligomerisation region BAA_4730 ENOG4105M59 Phosphodiesterase, mj0936 family BAA_4731 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BAA_4733 ENOG4108XJQ germination protein BAA_4735 ENOG4108PCX Major Facilitator BAA_4738 ENOG4105KBX Transcriptional regulator, TetR family BAA_4741 ENOG4105PFC Transcriptional regulator BAA_4744 ENOG4105DZC cytosine deaminase BAA_4745 ENOG4105DZC cytosine deaminase BAA_4746 ENOG4105DEF Extracellular solute-binding protein, family 5 BAA_4747 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BAA_4750 ENOG4108JQ7 (ABC) transporter BAA_4752 ENOG4105DY9 regulatoR BAA_4755 ENOG41067S9 phage shock protein C, PspC BAA_4756 ENOG4108JCI Transcriptional regulator BAA_4758 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BAA_4759 ENOG4108Z40 Transcriptional regulator BAA_4760 ENOG4105RHA ABC transporter, permease BAA_4761 ENOG4108IUX (ABC) transporter BAA_4762 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BAA_4765 ENOG4105E14 MotA TolQ exbB proton channel BAA_4766 ENOG4108VXD carboxy-peptidase BAA_4768 ENOG4105E33 succinate dehydrogenase BAA_4770 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BAA_4773 ENOG4105K63 Thioredoxin BAA_4774 ENOG4105C10 Electron transfer flavoprotein BAA_4775 ENOG4105BZJ Electron transfer flavoprotein BAA_4776 ENOG41060WC Enoyl-CoA hydratase BAA_4777 ENOG4107Z3H Transcriptional regulator, TetR family BAA_4778 ENOG4105CEY Amp-dependent synthetase and ligase BAA_4782 ENOG4105S6R Iron-hydroxamate transporter permease subunit BAA_4790 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BAA_4793 ENOG4105DR4 Methyltransferase BAA_4796 ENOG4105KFN sortase, SrtB family BAA_4797 ENOG4105E0A ABC, transporter BAA_4800 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BAA_4802 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BAA_4804 ENOG4105FE9 pseudouridine synthase BAA_4806 ENOG4105DCG PHP domain protein BAA_4812 ENOG4105C5S asparaginyl-tRNA synthetase BAA_4813 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BAA_4815 ENOG4108RWN rrna methyltransferase BAA_4822 ENOG4105C0R drug resistance transporter emrb qaca subfamily BAA_4823 ENOG4105CW7 secretion protein, HlyD family BAA_4824 ENOG4108JGH Tetr family transcriptional regulator BAA_4825 ENOG4105CN9 Peptidase m42 family protein BAA_4829 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BAA_4831 ENOG4105C22 threonyL-tRNA synthetase BAA_4832 ENOG4108TDW sporulation protein YtxC BAA_4836 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BAA_4838 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BAA_4839 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BAA_4841 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BAA_4842 ENOG4105C2M dna polymerase I BAA_4843 ENOG4105BZU Histidine kinase BAA_4844 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BAA_4849 ENOG4108HMX isocitrate dehydrogenase (NADP) BAA_4850 ENOG4105BZN citrate synthase BAA_4852 ENOG4108REF Sporulation integral membrane protein ytvi BAA_4853 ENOG4105FS0 cytoplasmic membrane protein BAA_4858 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BAA_4859 ENOG4105C6K Malic enzyme BAA_4860 ENOG4105C0B DNA polymerase III (alpha subunit) BAA_4862 ENOG4105VV2 BAA_4864 ENOG4105SFS phosphoesterase RecJ domain protein BAA_4872 ENOG4105DC7 peptidase M24 BAA_4879 ENOG4105Z7P Acetyltransferase (GNAT) family BAA_4880 ENOG41082W1 Cupin 2, conserved barrel domain protein BAA_4882 ENOG4105VZ8 Transcriptional regulator BAA_4886 ENOG4107YZX Universal stress protein BAA_4895 ENOG4108JYZ YitT family BAA_4899 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BAA_4901 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BAA_4902 ENOG4105KBJ sporulation protein ytfj BAA_4905 ENOG4105EFZ amidohydrolase BAA_4907 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BAA_4913 ENOG4106KR7 LysR family Transcriptional regulator BAA_4918 ENOG4105C28 cystathionine BAA_4922 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BAA_4924 ENOG4105EMN RNA polymerase sigma factor BAA_4927 ENOG4105F1V Acetoin utilization protein BAA_4928 ENOG4105W87 Cbs domain BAA_4929 ENOG4105DGU Histone deacetylase BAA_4931 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BAA_4933 ENOG4107SNB ankyrin repeat protein YahD BAA_4934 ENOG4105EP9 oxidoreductase BAA_4940 ENOG4105ETE Transcriptional regulator (LacI family BAA_4944 ENOG4105C88 aminopeptidase BAA_4952 ENOG4108VDD TRNA binding domain protein BAA_4958 ENOG4105C8F Beta-lactamase domain protein BAA_4961 ENOG4108V15 phosphotransferase enzyme family BAA_4962 ENOG4108IUM Glycogen debranching enzyme BAA_4966 ENOG4105YW5 deoR family transcriptional regulator BAA_4969 ENOG4105CBX hi0933 family BAA_4978 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BAA_4979 ENOG4105CSC Glucose uptake protein BAA_4982 ENOG4108ZAF Molybdopterin BAA_4983 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BAA_4984 ENOG4105CVM Molybdenum cofactor synthesis domain protein BAA_4986 ENOG4105D06 uba thif-type nad fad binding protein BAA_4992 ENOG41085GJ domain protein BAA_4994 ENOG4105DWV Homoserine O-trans-acetylase BAA_4998 ENOG4108B31 Spore germination protein BAA_5005 ENOG410605W Major Facilitator BAA_5006 ENOG4107S91 Sodium hydrogen exchanger BAA_5007 ENOG4105NCW Trka-c domain protein BAA_5010 ENOG4105C19 ABC transporter BAA_5014 ENOG4105N5T Radical SAM Protein BAA_5016 ENOG4105DA5 (ABC) transporter BAA_5022 ENOG4105E8V Alpha Beta Hydrolase Fold protein BAA_5024 ENOG4108Z0R Transferase BAA_5025 ENOG4105YVM Phosphoesterase, PA-phosphatase related BAA_5026 ENOG4105BZF Glycosyl transferase (Group 1 BAA_5028 ENOG4108RIR Molybdenum cofactor biosynthesis protein BAA_5039 ENOG4105EGD dinuclear metal center protein, YbgI family BAA_5040 ENOG4105BZU Histidine kinase BAA_5041 ENOG4105BZU Histidine kinase BAA_5042 ENOG4107S9D Alpha beta hydrolase BAA_5047 ENOG4105D2X ABC transporter substrate-binding protein BAA_5049 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BAA_5059 ENOG4108V2W Carbonate dehydratase BAA_5061 ENOG4105C4M (Ubiquinol oxidase) subunit I BAA_5062 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BAA_5072 ENOG41087YS Phage shock protein A BAA_5079 ENOG4105BZU Histidine kinase BAA_5080 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAA_5085 ENOG4108UGV hypoxanthine phosphoribosyltransferase BAA_5086 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BAA_5093 ENOG4107ZTW SNARE associated Golgi BAA_5096 ENOG4105C19 ABC transporter BAA_5097 ENOG41086D8 Transcriptional regulator BAA_5108 ENOG4105C6Z Gluconate BAA_5109 ENOG4105FDP GntR family transcriptional regulator BAA_5113 ENOG41069H0 dihydroorotase EC 3.5.2.3 BAA_5119 ENOG4105DTQ mandelate racemase muconate lactonizing BAA_5121 ENOG4108IPT Naphthoate synthase BAA_5122 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BAA_5123 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BAA_5124 ENOG4105E4F Isochorismate synthase BAA_5125 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BAA_5127 ENOG4105VEQ Cold shock protein BAA_5132 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BAA_5134 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BAA_5136 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BAA_5163 ENOG4105KT7 mgtC SapB transporter BAA_5165 ENOG4107PBV potassium channel BAA_5166 ENOG4107QYV phosphohexose isomerase BAA_5167 ENOG4105WG9 Conserved Protein BAA_5169 ENOG4105CHM Aminotransferase BAA_5170 ENOG4108ZB6 transcriptional regulator AsnC family BAA_5171 ENOG4105C5I Dehydrogenase BAA_5172 ENOG4108MUZ hydrolase BAA_5174 ENOG4105C87 Aminotransferase class I and II BAA_5177 ENOG4105Y38 Kinase-associated protein B BAA_5179 ENOG4107R3E Citrate transporter BAA_5183 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BAA_5184 ENOG4105KA0 thioesterase Superfamily protein BAA_5188 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BAA_5192 ENOG41069ER domain protein BAA_5195 ENOG4105CEP NADH dehydrogenase BAA_5202 ENOG4105EWC Purine nucleoside phosphorylase BAA_5206 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BAA_5211 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BAA_5212 ENOG4105C4B ABC transporter, permease BAA_5213 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BAA_5222 ENOG41083MR nifu domain-containing protein BAA_5225 ENOG4108W5N phosphatidylglycerophosphatase a BAA_5227 ENOG4105DYS nad(p)h dehydrogenase (quinone) BAA_5228 ENOG4105D4U had-superfamily hydrolase, subfamily iia BAA_5231 ENOG4105CBT Fructose-1,6-bisphosphatase BAA_5234 ENOG4105MMD transcriptional regulator BAA_5235 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BAA_5236 ENOG4107TXC Transcriptional regulator BAA_5237 ENOG41090T1 Membrane BAA_5242 ENOG4105FAA peptidase M23 BAA_5244 ENOG4105KZD Domain of unknown function (DUF1805) BAA_5245 ENOG4107R8B 5'-nucleotidase BAA_5249 ENOG4105DIW FeS assembly protein SUFB BAA_5250 ENOG4108UNV SUF system FeS assembly protein, NifU family BAA_5251 ENOG4105C9B Cysteine desulfurase BAA_5252 ENOG4105JRK feS assembly protein SufD BAA_5253 ENOG4105C3K feS assembly ATPase SufC BAA_5254 ENOG4105D01 (LipO)protein BAA_5255 ENOG4105D01 (LipO)protein BAA_5256 ENOG4108UMI ABC transporter, permease BAA_5264 ENOG41080E8 Transcriptional regulator, Spx MgsR family BAA_5272 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BAA_5277 ENOG4108W8B Beta-lactamase domain protein BAA_5278 ENOG4105C1G acyl-Coa dehydrogenase BAA_5280 ENOG4105CHU acetyl-coa acetyltransferase BAA_5283 ENOG4105DZ1 carboxypeptidase BAA_5287 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BAA_5291 ENOG4108SUT Major Facilitator Superfamily BAA_5292 ENOG4107R7I amino acid BAA_5294 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BAA_5296 ENOG4107AYK membrAne BAA_5303 ENOG4107ZTW SNARE associated Golgi BAA_5305 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BAA_5306 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAA_5307 ENOG4105BZU Histidine kinase BAA_5309 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BAA_5312 ENOG4105VG1 fes assembly suf system protein BAA_5313 ENOG4105D4Y metalloprotease BAA_5317 ENOG4107S91 Sodium hydrogen exchanger BAA_5318 ENOG4105NCW Trka-c domain protein BAA_5320 ENOG4108RMU ferritin dps family protein BAA_5324 ENOG4108URH decarboxylase BAA_5329 ENOG4105D9N nucleoside BAA_5330 ENOG4105D9N nucleoside BAA_5333 ENOG4108RYK Nad-dependent epimerase dehydratase BAA_5338 ENOG4105CV8 reductase BAA_5339 ENOG4105F27 Major Facilitator BAA_5340 ENOG4105KVH Transcriptional regulator BAA_5343 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BAA_5344 ENOG4105D4A Cell wall formation (By similarity) BAA_5346 ENOG4105C8Q Methyl-accepting chemotaxis BAA_5348 ENOG4105WMR Protein CrcB homolog BAA_5349 ENOG4105WMR Protein CrcB homolog BAA_5352 ENOG4108MK9 spermidine N(1)-acetyltransferase BAA_5353 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BAA_5356 ENOG4108IPW abc transporter atp-binding protein BAA_5357 ENOG4105CM4 permease protein BAA_5365 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BAA_5367 ENOG4105XZU Preprotein translocase, subunit SecG BAA_5368 ENOG41067MG lrgb family BAA_5388 ENOG4105EFC phage portal protein HK97 family BAA_5393 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BAA_5395 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BAA_5396 ENOG4105CP7 Triose-phosphate isomerase BAA_5401 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BAA_5405 ENOG41090VF Stage v sporulation protein ac BAA_5406 ENOG4105CZ3 stage V sporulation protein ad BAA_5409 ENOG4105H67 Protein of unknown function (DUF421) BAA_5410 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BAA_5411 ENOG4105KRI phosphocarrier protein (HPr BAA_5413 ENOG4105CHW UPF0052 protein BAA_5415 ENOG4108Z4K mutator MutT protein BAA_5417 ENOG4105C3M thioredoxin reductase BAA_5419 ENOG4108S4C acetyltransferase BAA_5423 ENOG41086DT Membrane protein of unknown function BAA_5425 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BAA_5426 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BAA_5427 ENOG4105D7V transposase BAA_5430 ENOG4107TXC Transcriptional regulator BAA_5435 ENOG4105HMI Membrane BAA_5436 ENOG4105DUM transcriptional regulator, lysR family BAA_5438 ENOG4108WS4 fmn reductase BAA_5441 ENOG4105BZ1 (ABC) transporter BAA_5443 ENOG4105CN1 protease BAA_5444 ENOG4105CRP Part of the ABC transporter FtsEX involved in BAA_5445 ENOG4105CAK Cell division ATP-binding protein ftsE BAA_5450 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BAA_5451 ENOG4105MS2 ribosomal subunit Interface protein BAA_5453 ENOG4105VEQ Cold shock protein BAA_5454 ENOG41081UC Inherit from COG: Competence protein BAA_5457 ENOG4105KVH Transcriptional regulator BAA_5459 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BAA_5460 ENOG4108KGH TRANSCRIPTIONal BAA_5461 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BAA_5462 ENOG4105C6Y Udp-glucose 6-dehydrogenase BAA_5463 ENOG4105ESV Glycosyl transferase, family 4 BAA_5465 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BAA_5468 ENOG410901P UPF0249 protein BAA_5469 ENOG4105F8D glycoside hydrolase family 4 BAA_5470 ENOG4105VCP PTS System BAA_5471 ENOG4105CK1 PTS System BAA_5473 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BAA_5474 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BAA_5475 ENOG4105VCP PTS System BAA_5477 ENOG4105VZJ PTS System BAA_5480 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BAA_5481 ENOG4105ECB domain protein BAA_5482 ENOG4107RSM transcriptional regulator BAA_5493 ENOG4105DAA L-lactate BAA_5495 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BAA_5497 ENOG4105E0M Sulfatase BAA_5507 ENOG4105C94 Transporter BAA_5508 ENOG41069ER domain protein BAA_5513 ENOG4105KBK Zinc finger, swim domain protein BAA_5514 ENOG4105C0D helicase BAA_5520 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BAA_5522 ENOG4107RBB ABC transporter, permease BAA_5523 ENOG4105C19 ABC transporter BAA_5527 ENOG4105CXY transporter BAA_5530 ENOG4105BZU Histidine kinase BAA_5531 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAA_5532 ENOG4105CMR udp-glucose 4-epimerase BAA_5536 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BAA_5537 ENOG4105EY8 ABC transporter BAA_5548 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BAA_5551 ENOG4105FRN stage II sporulation protein BAA_5559 ENOG4106778 Protein of unknown function (DUF1146) BAA_5560 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BAA_5561 ENOG4105C8S subunit m BAA_5562 ENOG4105D65 subunit l BAA_5567 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BAA_5568 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BAA_5570 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BAA_5571 ENOG4105BZU Histidine kinase BAA_5581 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BAA_5582 ENOG41062M3 atp synthase BAA_5588 ENOG4108YZG isomerase BAA_5591 ENOG4108VGI doxx family BAA_5592 ENOG4107XC4 flavin reductase domain protein, FMN-binding BAA_5595 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BAA_5597 ENOG4108ZXQ stage ii sporulation protein r BAA_5598 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BAA_5599 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BAA_5602 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BAA_5603 ENOG4105CBT Fructose-1,6-bisphosphatase BAA_5604 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BAA_5611 ENOG4105C1G acyl-Coa dehydrogenase BAA_5612 ENOG4105C1G acyl-Coa dehydrogenase BAA_5613 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BAA_5615 ENOG4105DF6 Fe-S oxidoreductase BAA_5618 ENOG4105BZU Histidine kinase BAA_5623 ENOG4105BZU Histidine kinase BAA_5624 ENOG4105KCT ABC transporter BAA_5625 ENOG4108M15 ABC transporter BAA_5626 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BAA_5632 ENOG4105IIU Aminopeptidase BAA_5636 ENOG4105EMN RNA polymerase sigma factor BAA_5638 ENOG410684U Domain of unknown function (DUF1934) BAA_5643 ENOG4105CYW agmatinase BAA_5645 ENOG4105DXB Major Facilitator superfamily BAA_5646 ENOG4107SWG transcriptional regulator MERR family BAA_5648 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BAA_5649 ENOG4105BZ4 penicillin-binding protein BAA_5650 ENOG4108XFG YwhD family BAA_5651 ENOG4108Z4T Peptidase M50 BAA_5652 ENOG41069HH 4-oxalocrotonate tautomerase BAA_5653 ENOG4105DCI Phosphohydrolase BAA_5654 ENOG4108MES Periplasmic binding protein BAA_5655 ENOG4105E0A ABC, transporter BAA_5656 ENOG4105EHG Permease protein BAA_5660 ENOG4108VCI transcription factor, rsfa family BAA_5663 ENOG4108IJ2 phosphate acetyltransferase BAA_5666 ENOG4108VKI Cell wall hydrolase BAA_5673 ENOG410667J hydrolase BAA_5674 ENOG4105VCH membrane BAA_5676 ENOG4108TU7 Inherit from COG: (ABC) transporter BAA_5677 ENOG4105CJ1 ABC, transporter BAA_5678 ENOG41090WU lipolytic protein G-D-S-L family BAA_5681 ENOG4105D6E homoserine dehydrogenase BAA_5687 ENOG4108Y4K DNA-binding transcriptional activator BAA_5689 ENOG4105WH1 Two component transcriptional regulator luxr family BAA_5692 ENOG4105DWF phosphomethylpyrimidine kinase BAA_5693 ENOG4105BZU Histidine kinase BAA_5694 ENOG4105VCD cytoplasmic protein BAA_5695 ENOG4105D22 carbon starvation protein BAA_5696 ENOG4105DY9 regulatoR BAA_5697 ENOG41079KZ Major Facilitator Superfamily BAA_5702 ENOG4105EN6 Membrane BAA_5703 ENOG4106YBV Methyl-accepting chemotaxis BAA_5705 ENOG4108S4H thioesterase Superfamily protein BAA_5707 ENOG4105JEU Glycosyl transferase, family 2 BAA_5708 ENOG4105C5H ABC transporter BAA_5713 ENOG4105CKK Glycosyl transferase, family 2 BAA_5714 ENOG41067SE Tetr family transcriptional regulator BAA_5716 ENOG4105E0X reductase BAA_5718 ENOG4106F5Q Membrane BAA_5721 ENOG4105DY9 regulatoR BAA_5722 ENOG4108HRK Histidine kinase BAA_5724 ENOG4107RGD Major Facilitator superfamily BAA_5727 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BAA_5729 ENOG4105IW1 AmiS UreI transporter BAA_5731 ENOG4105CMR udp-glucose 4-epimerase BAA_5732 ENOG4108UT2 hemolysin iii BAA_5734 ENOG4105C1J atp-dependent rna helicase BAA_5737 ENOG4105DPN Oligoendopeptidase f BAA_5741 ENOG4105C0H protease BAA_5742 ENOG4105Q2H domain protein BAA_5745 ENOG4105BZU Histidine kinase BAA_5746 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAA_5752 ENOG4105CDU Replicative dna helicase BAA_5754 ENOG4105BZR domain protein BAA_5755 ENOG4108XMW Membrane BAA_5757 ENOG4108UUM single-stranded DNA-binding protein BAA_5759 ENOG4105C3G gtp-binding protein BAA_5760 ENOG4105VDK protein, conserved in bacteria BAA_5761 ENOG4105D8X mechanosensitive ion channel BAA_5762 ENOG4108ZDA Sporulation protein YyaC BAA_5763 ENOG4105FA0 parb-like partition protein BAA_5764 ENOG4107QJE Chromosome Partitioning Protein BAA_5768 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BAA_5770 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BAA_A0013 ENOG4105EKQ RNA-directed DNA polymerase BAA_A0035 ENOG4105EKQ RNA-directed DNA polymerase BAA_A0064 ENOG4105CNU cell division protein FtsK BAA_A0115 ENOG4105DHF Membrane BAA_A0122 ENOG4106AKK s-layer domain-containing protein BAA_A0123 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BAA_A0128 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BAA_A0129 ENOG4105C6Y Udp-glucose 6-dehydrogenase BAA_A0150 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BAA_A0180 ENOG4105KRN Transcriptional regulator, abrb family BAA_A0183 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BAA_A0192 ENOG4108IBT Inherit from COG: transposase BAA_A0201 ENOG4108MEK Metal-binding protein YodA BAA_A0204 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) BAA_A0211 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BAA_B0007 ENOG4105K4H Nlp p60 protein BAA_B0043 ENOG4107QJE Chromosome Partitioning Protein BAA_B0056 ENOG4105EWC Purine nucleoside phosphorylase BAA_B0077 ENOG4105C3F Signal peptidase i BAA_B0084 ENOG4105N14 lysine exporter protein LysE YggA BAA_B0092 ENOG4108J59 Extracellular solute-binding protein, family 5 BAA_B0096 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)