locus-tag class description A16_00020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A16_00030 ENOG410848D S4 domain protein YaaA A16_00060 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A16_00110 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) A16_00180 ENOG4105ZMH deoxynucleoside kinase A16_00200 ENOG4105GTG Isochorismatase A16_00210 ENOG4108Z6B deaminase A16_00220 ENOG4105C6E dna polymerase iii A16_00260 ENOG41067KS pro-sigma K processing A16_00330 ENOG4105CXN decarboxylase A16_00350 ENOG4105FA2 dna polymerase iii A16_00360 ENOG4105MA4 psp1 domain protein A16_00380 ENOG41060K3 Methyltransferase A16_00400 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) A16_00410 ENOG4105KRN Transcriptional regulator, abrb family A16_00430 ENOG4105F8V Hydrolase, tatD family A16_00440 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) A16_00460 ENOG4105XFA sporulation peptidase YabG A16_00470 ENOG4105W42 Veg protein A16_00500 ENOG4105DFT pur operon repressor A16_00520 ENOG4105KME endoribonuclease L-psp A16_00550 ENOG4105C5T Phosphoribosyl pyrophosphate synthase A16_00560 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) A16_00580 ENOG4108JA2 transcriptioN-repair coupling factor A16_00590 ENOG4108M14 stage v sporulation protein t A16_00610 ENOG4108IY2 MazG family A16_00620 ENOG41082I2 s4 domain protein A16_00630 ENOG4105VYY sporulation protein yabp A16_00660 ENOG41060GV RNA binding s1 domain protein A16_00700 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) A16_00710 ENOG4108UGV hypoxanthine phosphoribosyltransferase A16_00720 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) A16_00750 ENOG4105C6T cysteine synthase A16_00760 ENOG4105CRQ synthase (Component I) A16_00770 ENOG4105DDQ anthranilate synthase A16_00780 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 A16_00790 ENOG4105EEI dihydropteroate synthase A16_00800 ENOG4105KRF dihydroneopterin aldolase A16_00810 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase A16_00830 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) A16_00890 ENOG4108Z0C Uvrb UvrC protein A16_00930 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) A16_00950 ENOG4105CTP PilT protein domain protein A16_00990 ENOG4105D7W serine acetyltransferase A16_01020 ENOG4105C2N RNA methyltransferase TrmH family group 3 A16_01030 ENOG4105M0M Tetracycline resistance protein A16_01040 ENOG4105QIV RNA polymerase A16_01060 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) A16_01110 ENOG4107Y49 methyltransferase A16_01140 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A16_01150 ENOG4105XPM ribosomal protein A16_01360 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) A16_01410 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) A16_01430 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) A16_01450 ENOG41067V7 50S ribosomal protein L36 A16_01510 ENOG4108JJB ABC transporter A16_01520 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) A16_01530 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) A16_01580 ENOG4105D1F ATP-binding protein A16_01610 ENOG4108NMV polysaccharide deacetylase A16_01780 ENOG4105C8B TIGR00159 family A16_01820 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) A16_01830 ENOG4108VQT Alpha beta hydrolase fold protein A16_01880 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) A16_01890 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein A16_01970 ENOG4108PSK reductase A16_01980 ENOG4108UMI ABC transporter, permease A16_01990 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) A16_02000 ENOG4105D01 (LipO)protein A16_02010 ENOG4105EE1 crotonyl-CoA reductase A16_02030 ENOG4105IQ5 FAD linked oxidase domain protein A16_02060 ENOG4105C2C drug resistance transporter, Bcr CflA A16_02090 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A16_02100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A16_02110 ENOG4105C3U ABC transporter A16_02120 ENOG4108JQ7 (ABC) transporter A16_02180 ENOG4108J59 Extracellular solute-binding protein, family 5 A16_02190 ENOG4108J59 Extracellular solute-binding protein, family 5 A16_02210 ENOG4105II7 pyrroline-5-carboxylate reductase A16_02220 ENOG4107XDY Nicotinamide Mononucleotide Transporter A16_02240 ENOG4105E0C molybdate abc transporter A16_02250 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein A16_02260 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein A16_02270 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family A16_02280 ENOG4105EGI Transcriptional regulator A16_02310 ENOG4105F6E Acyl-transferase A16_02350 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) A16_02380 ENOG4108RE7 deoxyribonuclease A16_02390 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) A16_02440 ENOG4105C5H ABC transporter A16_02480 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein A16_02500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A16_02510 ENOG4105C3U ABC transporter A16_02520 ENOG4108JQ7 (ABC) transporter A16_02570 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase A16_02580 ENOG4105ERH Fumarylacetoacetate hydrolase A16_02600 ENOG4108SC4 )-transporter A16_02610 ENOG4105CPF Cell wall formation (By similarity) A16_02620 ENOG4105CPF Cell wall formation (By similarity) A16_02630 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) A16_02660 ENOG4107ZXI Rhomboid family A16_02680 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein A16_02690 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A16_02710 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) A16_02900 ENOG4105K8N protein family UPF0079, ATPase A16_02910 ENOG41072GX Peptidase M22 Glycoprotease A16_02920 ENOG410801F ribosomal-protein-alanine acetyltransferase A16_02930 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A16_02940 ENOG4105C5H ABC transporter A16_02970 ENOG4108TYN CAAX amino terminal protease family protein A16_03010 ENOG4105C7N Xanthine uracil vitamin C permease A16_03030 ENOG4105BZU Histidine kinase A16_03090 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) A16_03180 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) A16_03220 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A16_03260 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) A16_03270 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit A16_03280 ENOG4105C83 adenylosuccinate lyase A16_03300 ENOG4105VR9 phosphoribosylformylglycinamidine synthase A16_03350 ENOG4108V3E phosphoribosylglycinamide formyltransferase A16_03370 ENOG4105C12 Phosphoribosylglycinamide synthetase A16_03420 ENOG4105C4R Atp-dependent dna helicase A16_03480 ENOG4108W2Y isochorismatase A16_03490 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) A16_03500 ENOG4108UMI ABC transporter, permease A16_03510 ENOG4105D01 (LipO)protein A16_03550 ENOG410834F Transcriptional regulator A16_03600 ENOG4105CBD Diacylglycerol kinase A16_03610 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) A16_03620 ENOG4108JPW Aminotransferase A16_03640 ENOG4105C26 Dehydrogenase A16_03650 ENOG4105KPY Small multidrug resistance protein A16_03690 ENOG4105D9N nucleoside A16_03700 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A16_03730 ENOG4108W15 Protein of unknown function (DUF1456) A16_03760 ENOG4105DTQ mandelate racemase muconate lactonizing A16_03780 ENOG4105DFD Na H antiporter A16_03820 ENOG4105D3R alkyl hydroperoxide reductase A16_03860 ENOG4107W7X Aldolase A16_03870 ENOG4105EHG Permease protein A16_03880 ENOG4105DQ5 transport system permease protein A16_03890 ENOG4108V5C ABC transporter A16_03930 ENOG4106UIA A16_03940 ENOG4106UIA A16_03990 ENOG4105BZU Histidine kinase A16_04030 ENOG410756H nucleotidyltransferase A16_04040 ENOG4105D2S major facilitator superfamily A16_04070 ENOG4105E5Q amino acid AbC transporter A16_04080 ENOG4105EAB amino acid AbC transporter A16_04100 ENOG4105C8Q Methyl-accepting chemotaxis A16_04110 ENOG4105C8Q Methyl-accepting chemotaxis A16_04130 ENOG4105CI1 PTS System A16_04200 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter A16_04230 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component A16_04260 ENOG4105C5H ABC transporter A16_04310 ENOG41062JF Transcriptional regulator A16_04350 ENOG4105DEU major facilitator superfamily A16_04380 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) A16_04410 ENOG4108N0M stress protein A16_04420 ENOG4106FN3 tellurium resistance protein A16_04430 ENOG4106FN3 tellurium resistance protein A16_04440 ENOG4107TS3 membrane protein, TerC A16_04450 ENOG4108TTB tellurium resistance protein A16_04490 ENOG4105KJF protein tyrosine phosphatase A16_04510 ENOG4107U9T Pfam:Ribonuclease_BN A16_04520 ENOG4105C59 p-type ATPase A16_04530 ENOG4108IPJ Membrane A16_04580 ENOG4107ZTW SNARE associated Golgi A16_04610 ENOG410606W general stress protein A16_04620 ENOG4105UPD Calcium Proton A16_04700 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A16_04710 ENOG4105VTR Integrase A16_05270 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) A16_05290 ENOG4108JUB Transcriptional regulator A16_05310 ENOG4108IQI permease A16_05370 ENOG4105CSV Glutaminase A16_05400 ENOG4108A04 Beta-lactamase A16_05430 ENOG4105CKK Glycosyl transferase, family 2 A16_05460 ENOG4105C3I Nad-dependent epimerase dehydratase A16_05490 ENOG4105F1A Pyruvate formate-lyase A16_05530 ENOG4105CI2 imidazolone-5-propionate hydrolase A16_05540 ENOG4105ECP epimerase A16_05600 ENOG41067AE Membrane-bound metal-dependent hydrolase A16_05610 ENOG4105CEN a g-specific adenine glycosylase A16_05620 ENOG4106BXE A16_05680 ENOG4105BZ1 (ABC) transporter A16_05690 ENOG4107NBY Membrane A16_05700 ENOG4105CBC glutamate synthase A16_05720 ENOG4108IUW ABC transporter A16_05760 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A16_05770 ENOG4105G5W regulator Fur family A16_06000 ENOG4108JQC penicillin-binding protein 1A A16_06010 ENOG4107ZQN disulfide bond A16_06030 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) A16_06050 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) A16_06060 ENOG4105BZU Histidine kinase A16_06070 ENOG4105CYN Serine protein kinase A16_06110 ENOG4105C94 Transporter A16_06140 ENOG4105DZ6 Band 7 protein A16_06160 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism A16_06190 ENOG4105D4T Citrate transporter A16_06230 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator A16_06240 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A16_06250 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component A16_06260 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component A16_06270 ENOG4105BZ7 extracellular solute-binding protein family 1 A16_06280 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) A16_06290 ENOG4108STX response regulator A16_06300 ENOG4105US7 Histidine kinase A16_06350 ENOG4108MRH transcriptional regulatory protein A16_06370 ENOG4105C6K Malic enzyme A16_06390 ENOG4108UZ3 Transporter A16_06400 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A16_06420 ENOG4105BZU Histidine kinase A16_06430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A16_06450 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) A16_06460 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) A16_06470 ENOG4108JB9 formate dehydrogenase A16_06520 ENOG4105CUB amino acid A16_06540 ENOG4105C59 p-type ATPase A16_06550 ENOG4105DAP Nicotinate phosphoribosyltransferase A16_06630 ENOG41073R8 VanW family A16_06640 ENOG4108KGH TRANSCRIPTIONal A16_06650 ENOG4105D9N nucleoside A16_06670 ENOG4105C37 (CBS) domain A16_06680 ENOG4108IJ0 Aspartate ammonia-lyase A16_06690 ENOG4105DAA L-lactate A16_06720 ENOG4105DUX Transporter A16_06730 ENOG4108MES Periplasmic binding protein A16_06740 ENOG4105DQ5 transport system permease protein A16_06750 ENOG4108IHU transport system permease protein A16_06760 ENOG4105E0A ABC, transporter A16_06800 ENOG4105EXW epimerase dehydratase A16_06840 ENOG4105GMT ATPase associated with various cellular activities aaa_5 A16_06850 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) A16_06880 ENOG4105BZU Histidine kinase A16_06890 ENOG4105D5Q Arginine ornithine antiporter A16_06910 ENOG4105C5Y PTS System A16_06930 ENOG4105CG3 alpha amylase, catalytic region A16_06960 ENOG4105E1K spore germination protein A16_06980 ENOG4105CRN Aminoglycoside phosphotransferase A16_06990 ENOG4105BZG amino acid carrier protein A16_07000 ENOG4105CDA abc transporter atp-binding protein A16_07010 ENOG4105CT1 (ABC) transporter A16_07020 ENOG4105EAD ABC transporter A16_07030 ENOG4105DRP amino acid AbC transporter A16_07040 ENOG4108IQI permease A16_07090 ENOG4105D29 Helix-turn-helix type 11 domain protein A16_07100 ENOG4105NAE bifunctional deaminase-reductase domain protein A16_07110 ENOG4105BZU Histidine kinase A16_07150 ENOG4105CHH sulfate transporter A16_07160 ENOG41068KF Universal stress protein A16_07180 ENOG4105DEF Extracellular solute-binding protein, family 5 A16_07200 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A16_07210 ENOG4108JQ7 (ABC) transporter A16_07230 ENOG4105CXY transporter A16_07240 ENOG41067TZ transcriptional regulator, MarR family A16_07250 ENOG4105C0R drug resistance transporter emrb qaca subfamily A16_07260 ENOG4105C0R drug resistance transporter emrb qaca subfamily A16_07290 ENOG4108RVA ribokinase A16_07310 ENOG4105C2J ABC transporter A16_07320 ENOG4105CNN ABC, transporter A16_07330 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator A16_07340 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) A16_07460 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) A16_07470 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer A16_07480 ENOG41069ER domain protein A16_07490 ENOG4105VZ8 Transcriptional regulator A16_07500 ENOG4107D63 A16_07520 ENOG4105DUX Transporter A16_07560 ENOG4105C85 amino acid A16_07570 ENOG4105C7N Xanthine uracil vitamin C permease A16_07650 ENOG4105BZ9 Cytochrome C oxidase, subunit I A16_07660 ENOG4105E2S oxidase) subunit II A16_07690 ENOG4106CAD Protein of unknown function (DUF3311) A16_07700 ENOG4105E1V na solute symporter A16_07730 ENOG4108NHD germination protein A16_07750 ENOG4105CE1 Ferrous iron transport protein b A16_07760 ENOG4105CE1 Ferrous iron transport protein b A16_07770 ENOG4105CE1 Ferrous iron transport protein b A16_07780 ENOG4105CVA phosphate A16_07790 ENOG4105C8U phosphate abc transporter A16_07800 ENOG4105E2Z phosphate ABC transporter (Permease A16_08050 ENOG41080XQ Signal transduction protein with cbs domains A16_08100 ENOG4105ETU transcriptional activator (TenA A16_08120 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component A16_08140 ENOG4108VEU Thiamine monophosphate synthase A16_08150 ENOG41080HI glycine oxidase A16_08180 ENOG4105D06 uba thif-type nad fad binding protein A16_08190 ENOG4105DWF phosphomethylpyrimidine kinase A16_08280 ENOG4108INS Transcriptional regulator A16_08310 ENOG4105C7N Xanthine uracil vitamin C permease A16_08380 ENOG4105C5Y PTS System A16_08510 ENOG4107Y03 Nitroreductase A16_08520 ENOG4105ED1 spovr family A16_08580 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase A16_08590 ENOG4105XTG Pfam:DUF156 A16_08600 ENOG4105VFE sira family A16_08610 ENOG4107TPS domain protein A16_08620 ENOG4105VFE sira family A16_08630 ENOG41085GJ domain protein A16_08650 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase A16_08660 ENOG41087NI Sulfite exporter TauE/SafE A16_08680 ENOG4108KGH TRANSCRIPTIONal A16_08740 ENOG4105EMD TRANSCRIPTIONal A16_08750 ENOG4105VCP PTS System A16_08760 ENOG4105VZJ PTS System A16_08800 ENOG41069ER domain protein A16_08810 ENOG4107RBB ABC transporter, permease A16_08820 ENOG4105C19 ABC transporter A16_08890 ENOG4105WEF catalase A16_08960 ENOG4107T5V SNARE associated Golgi A16_09030 ENOG4105CUB amino acid A16_09040 ENOG4107RWR Sodium hydrogen exchanger A16_09060 ENOG4106KNT transcriptional regulator A16_09130 ENOG4108PCN EamA-like transporter family A16_09140 ENOG4108YXU transcriptional regulator AsnC family A16_09160 ENOG4105KPY Small multidrug resistance protein A16_09170 ENOG4105KPY Small multidrug resistance protein A16_09220 ENOG4105NF4 modulator of drug activity A16_09230 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) A16_09240 ENOG4105E5W Transporter A16_09260 ENOG4107RKG DJ-1/PfpI family A16_09270 ENOG4105CH6 catalase A16_09300 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) A16_09320 ENOG4105C26 Dehydrogenase A16_09330 ENOG4105BZ1 (ABC) transporter A16_09370 ENOG4105DRP amino acid AbC transporter A16_09380 ENOG4105CDA abc transporter atp-binding protein A16_09410 ENOG410839P A16_09480 ENOG4107FQX Alpha-acetolactate decarboxylase A16_09550 ENOG4105D4P Coproporphyrinogen iii oxidase A16_09580 ENOG4105CHH sulfate transporter A16_09670 ENOG4106AKK s-layer domain-containing protein A16_09690 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein A16_09700 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein A16_09730 ENOG4105CGU Enoyl-CoA hydratase A16_09760 ENOG4105DER m42 family A16_09800 ENOG4105CTU Proline racemase A16_09890 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A16_09920 ENOG4108JQ7 (ABC) transporter A16_09980 ENOG4105CSH Transporter A16_10000 ENOG4108MRH transcriptional regulatory protein A16_10110 ENOG4105CDU Replicative dna helicase A16_10180 ENOG4105C0R drug resistance transporter emrb qaca subfamily A16_10270 ENOG4107P5I polyketide synthase A16_10280 ENOG4108IG5 Transcriptional regulator A16_10320 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase A16_10360 ENOG4105CMT Dihydroxyacetone kinase A16_10380 ENOG4105CMT Dihydroxyacetone kinase A16_10390 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) A16_10400 ENOG410847I Transcriptional regulator, BadM Rrf2 family A16_10470 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase A16_10590 ENOG4105WN5 stage II sporulation protein A16_10610 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A16_10630 ENOG4108MJI response regulator A16_10640 ENOG4105BZU Histidine kinase A16_10650 ENOG4105BZU Histidine kinase A16_10700 ENOG4105K8R UPF0145 protein A16_10770 ENOG4107VRP DNA repair exonuclease A16_10780 ENOG4106D4I domain protein A16_10790 ENOG4105D7V transposase A16_10820 ENOG4108IND Tetr family transcriptional regulator A16_10830 ENOG4105EQ0 Major Facilitator superfamily A16_10880 ENOG4108MUZ hydrolase A16_10920 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator A16_10950 ENOG4105C6V Glycerol-3-phosphate dehydrogenase A16_10980 ENOG4105EMN RNA polymerase sigma factor A16_11030 ENOG4105C57 major facilitator superfamily A16_11040 ENOG4105C0R drug resistance transporter emrb qaca subfamily A16_11060 ENOG4105EEM helicase A16_11070 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A16_11120 ENOG4105K59 histidine triad (HIT) protein A16_11190 ENOG410905X membrane-flanked domain protein A16_11210 ENOG4105CKV Membrane A16_11290 ENOG410905X membrane-flanked domain protein A16_11300 ENOG4105CKV Membrane A16_11310 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation A16_11320 ENOG4105BZ4 penicillin-binding protein A16_11330 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) A16_11350 ENOG4105C1Q protoporphyrinogen oxidase A16_11400 ENOG4105NA0 Transcriptional regulator A16_11430 ENOG4105ECB domain protein A16_11490 ENOG4106AXD A16_11500 ENOG4108RQ5 Beta-lactamase domain-containing protein A16_11510 ENOG4105DF9 Lipoate-protein, ligase A16_11530 ENOG4105CEY Amp-dependent synthetase and ligase A16_11590 ENOG4105CNA YD repeat protein A16_11670 ENOG4105ENX hydrolase A16_11690 ENOG4107RN3 metallophosphoesterase A16_11700 ENOG4107TVP HD domain protein A16_11720 ENOG4108AEY RNA polymerase sigma factor A16_11730 ENOG41086D8 Transcriptional regulator A16_11770 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A16_11820 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 A16_11830 ENOG4105C8Q Methyl-accepting chemotaxis A16_11880 ENOG4105ZU5 s-layer protein A16_11890 ENOG4107QP3 malate synthase g A16_11920 ENOG4105VEQ Cold shock protein A16_11950 ENOG4105XVF Competence transcription factor A16_11980 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination A16_11990 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation A16_12070 ENOG4105ERH Fumarylacetoacetate hydrolase A16_12120 ENOG4105CAQ asparagine synthetase A16_12130 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) A16_12140 ENOG4105CH6 catalase A16_12150 ENOG4105BZU Histidine kinase A16_12190 ENOG4105QNR S1 RNA binding domain protein A16_12210 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A16_12230 ENOG4107AYK membrAne A16_12240 ENOG41073B9 A16_12260 ENOG4108KP7 hydrolase A16_12290 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit A16_12340 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) A16_12350 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) A16_12380 ENOG4105C31 Tryptophanyl-tRNA synthetase A16_12410 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A16_12420 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A16_12460 ENOG4105UQX Mate efflux family protein A16_12510 ENOG4108ZCF integral membrane protein A16_12530 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) A16_12550 ENOG4105DPN Oligoendopeptidase f A16_12580 ENOG4108Z18 K06886 hemoglobin A16_12590 ENOG4105MIX Adenylate cyclase A16_12620 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) A16_12630 ENOG4105EMS pseudouridine synthase A16_12700 ENOG4105K64 Glycosyl transferase, family 2 A16_12750 ENOG4107TVC Glycosyl transferase, family 2 A16_12790 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) A16_12800 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase A16_12820 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase A16_12920 ENOG4108WVJ 2'-5' rna ligase A16_12970 ENOG4105CK7 Sodium proline symporter A16_12990 ENOG4105CRQ synthase (Component I) A16_13000 ENOG4105DDQ anthranilate synthase A16_13180 ENOG4105C7S Dehydrogenase A16_13200 ENOG4105VZ8 Transcriptional regulator A16_13300 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) A16_13320 ENOG4105DZ1 carboxypeptidase A16_13330 ENOG4105VFR signal peptidase A16_13400 ENOG4105C26 Dehydrogenase A16_13410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A16_13420 ENOG4105F38 ABC transporter, permease A16_13430 ENOG4105D38 putrescine abc transporter A16_13440 ENOG4107RUE extracellular solute-binding protein family 1 A16_13460 ENOG4105EYF MMPL domain protein A16_13480 ENOG4108YBP pseudouridine synthase A16_13500 ENOG4105K4I Scp-like extracellular A16_13510 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) A16_13520 ENOG4105CQB FAD linked oxidase domain protein A16_13550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A16_13560 ENOG4105BZU Histidine kinase A16_13570 ENOG4105JXH GntR family transcriptional regulator A16_13610 ENOG4106A3R peptidase A16_13640 ENOG4108QTI )-transporter A16_13650 ENOG4107TS3 membrane protein, TerC A16_13680 ENOG410681C small acid-soluble spore protein A16_13690 ENOG4108Z7G MaoC domain protein dehydratase A16_13730 ENOG4105CHR reductase A16_13760 ENOG4105MWK D-amino acid dehydrogenase, small subunit A16_13800 ENOG4105C4Y ABC transporter A16_13830 ENOG4107RCV ABC transporter, permease A16_13840 ENOG4108KAZ Involved in phosphonate degradation (By similarity) A16_13870 ENOG4105E98 transcriptional regulator DeoR family A16_13950 ENOG4105PXI polysaccharide deacetylase A16_13970 ENOG4105BZU Histidine kinase A16_13980 ENOG41090MY MarR family Transcriptional regulator A16_14000 ENOG4106DF1 A16_14020 ENOG4105BZU Histidine kinase A16_14040 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase A16_14050 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) A16_14140 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) A16_14180 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A16_14190 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family A16_14200 ENOG4105CZV ABC transporter A16_14220 ENOG4105CJ1 ABC, transporter A16_14300 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A A16_14310 ENOG4105EA8 2-Nitropropane dioxygenase A16_14320 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD A16_14340 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein A16_14400 ENOG4105NQC Flavodoxin A16_14470 ENOG4107QMU Mate efflux family protein A16_14480 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) A16_14540 ENOG4105CZN Potassium uptake protein A16_14550 ENOG41063Y9 A16_14560 ENOG4105KBJ sporulation protein ytfj A16_14610 ENOG4105CM2 brancheD-chain amino acid aminotransferase A16_14620 ENOG4105C7K acetolactate synthase A16_14630 ENOG4108ZP8 Acetolactate synthase small subunit A16_14640 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase A16_14660 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A16_14710 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) A16_14780 ENOG4107RVV histidinol phosphate phosphatase, hisj family A16_14810 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase A16_14830 ENOG4105E0M Sulfatase A16_14850 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) A16_14890 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) A16_14900 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) A16_14920 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A16_14930 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein A16_14940 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein A16_14950 ENOG4105C8J )-transporter A16_14990 ENOG4105DFD Na H antiporter A16_15030 ENOG4105ENE Histidine kinase A16_15040 ENOG4105WH1 Two component transcriptional regulator luxr family A16_15070 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) A16_15120 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) A16_15160 ENOG4105CJ3 phosphate transporter A16_15170 ENOG4107GRR phosphate transport regulator A16_15180 ENOG4105BZ4 penicillin-binding protein A16_15220 ENOG4105BZU Histidine kinase A16_15230 ENOG4105I3N Conserved Protein A16_15260 ENOG4105BZU Histidine kinase A16_15330 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A16_15340 ENOG4105DZ1 carboxypeptidase A16_15350 ENOG4108JIC nucleoside recognition domain protein A16_15370 ENOG4105FE9 pseudouridine synthase A16_15390 ENOG4107TWT Cytochrome c biogenesis protein A16_15400 ENOG4105CRE cytochrome C A16_15410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A16_15420 ENOG4105BZU Histidine kinase A16_15430 ENOG4108WBT adenosyltransferase A16_15460 ENOG4108SAX Membrane A16_15480 ENOG4105T7X A16_15490 ENOG4105C9U ATP-dependent DNA helicase RecQ A16_15500 ENOG4105I7S Abortive infection protein A16_15540 ENOG4107X2D transcriptional regulator, merr family A16_15550 ENOG4108S6Z Negative regulator of genetic competence A16_15600 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase A16_15610 ENOG4107RB3 L-asparaginase A16_15670 ENOG4105S2F A16_15680 ENOG41065D1 A16_15740 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) A16_15770 ENOG4105XXQ heptaprenyl diphosphate synthase component I A16_15790 ENOG4105EAH synthase A16_15830 ENOG4105CIH Imidazole acetol-phosphate transaminase A16_15840 ENOG41068YB TPR repeat-containing protein A16_15870 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) A16_15880 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) A16_15890 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit A16_15950 ENOG4108JYZ YitT family A16_15960 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase A16_15990 ENOG4105FJR Lmbe family A16_16000 ENOG4105CPK Glycosyl transferase (Group 1 A16_16070 ENOG4105DVT helicase A16_16080 ENOG4105YAC A16_16120 ENOG4105CSM endonuclease III A16_16140 ENOG4105BZ4 penicillin-binding protein A16_16250 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) A16_16270 ENOG4105DVT helicase A16_16280 ENOG4105CTD carboxy-peptidase A16_16310 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) A16_16340 ENOG4105C2W permease A16_16350 ENOG4105DHF Membrane A16_16370 ENOG410890F Dynamin family A16_16390 ENOG4108W0I acetyltransferase A16_16410 ENOG4105KHC sulfurtransferase A16_16440 ENOG4106032 Glutathionylspermidine synthase A16_16570 ENOG4105CPK Glycosyl transferase (Group 1 A16_16600 ENOG4108SZE gCN5-related N-acetyltransferase A16_16640 ENOG41081VK Ribonuclease A16_16770 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A16_16790 ENOG4107RWR Sodium hydrogen exchanger A16_16800 ENOG4105CN5 Metallo-Beta-Lactamase A16_16810 ENOG4108Z5V transcriptional regulator, merr family A16_16830 ENOG4105H67 Protein of unknown function (DUF421) A16_16850 ENOG41080C8 DUF218 domain A16_16960 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) A16_16980 ENOG4107R0U MotA TolQ exbB proton channel A16_16990 ENOG4105ER2 Ompa motb domain protein A16_17000 ENOG4107YTP response regulator receiver protein A16_17030 ENOG4105DD5 Flagellar motor switch protein A16_17060 ENOG4105BZU Histidine kinase A16_17100 ENOG4105E1Q flagellar hook-associated protein A16_17110 ENOG4105DTJ flagellar hook-associated protein A16_17160 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) A16_17170 ENOG4108ZC9 flagellar basal-body rod protein flgc A16_17180 ENOG41075Z6 flagellar hook-basal body complex protein fliE A16_17190 ENOG4107U2N Flagellar M-ring protein A16_17210 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) A16_17290 ENOG4105BZE flagellar hook protein, FlgE A16_17360 ENOG4105K64 Glycosyl transferase, family 2 A16_17430 ENOG4107TVC Glycosyl transferase, family 2 A16_17480 ENOG4105I03 Flagellin A16_17490 ENOG4105E4C Lytic transglycosylase catalytic A16_17530 ENOG4105DD5 Flagellar motor switch protein A16_17550 ENOG4105CN7 Flagellar biosynthetic protein FliP A16_17560 ENOG4105VS8 Flagellar biosynthetic protein fliq A16_17580 ENOG4105D00 flagellar biosynthetic protein flhB A16_17590 ENOG4105D7B Flagellar biosynthesis protein flha A16_17620 ENOG4105KTQ flagellar basal-body rod protein A16_17630 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A16_17680 ENOG4108RZE Tetr family transcriptional regulator A16_17710 ENOG4105KAC Antibiotic biosynthesis monooxygenase A16_17760 ENOG4105DUM transcriptional regulator, lysR family A16_17770 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A16_17780 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein A16_17790 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component A16_17800 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) A16_17870 ENOG4105CVJ phosphoglycerate mutase A16_17940 ENOG4105CAQ asparagine synthetase A16_17980 ENOG4105PGM cation diffusion facilitator family transporter A16_18000 ENOG4105DRR Transcriptional regulator, GntR family A16_18010 ENOG4108UZ3 Transporter A16_18020 ENOG4105CKI cobalamin synthesis protein A16_18030 ENOG4108PJD permease A16_18070 ENOG4105DFD Na H antiporter A16_18080 ENOG4105C9Q fumarate hydratase class II A16_18140 ENOG4105EC3 peptidase S51, dipeptidase E A16_18180 ENOG4107QIV Cytochrome c biogenesis protein A16_18250 ENOG4106BRA Membrane A16_18320 ENOG4105CJ1 ABC, transporter A16_18370 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) A16_18390 ENOG4108IJ0 Aspartate ammonia-lyase A16_18400 ENOG4105C6K Malic enzyme A16_18540 ENOG4105FVX A16_18620 ENOG4105CSR polyphosphate kinase 2 A16_18670 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) A16_18700 ENOG4105EU0 Major facilitator Superfamily A16_18710 ENOG4105C6T cysteine synthase A16_18750 ENOG4105C8J )-transporter A16_18770 ENOG4105X5K response regulator receiver protein A16_18780 ENOG4105H67 Protein of unknown function (DUF421) A16_18820 ENOG4106KE4 Dehydrogenase A16_18850 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) A16_18860 ENOG4105CHR reductase A16_18870 ENOG4105CM2 brancheD-chain amino acid aminotransferase A16_18880 ENOG4105C7K acetolactate synthase A16_18890 ENOG4108ZP8 Acetolactate synthase small subunit A16_18900 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase A16_18920 ENOG4105C7B Threonine dehydratase A16_18960 ENOG4105C6X Major Facilitator A16_18970 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b A16_18990 ENOG4105DY9 regulatoR A16_19000 ENOG4105CYC Transferase A16_19050 ENOG4108J59 Extracellular solute-binding protein, family 5 A16_19110 ENOG41068WN A16_19160 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) A16_19170 ENOG4105C72 UPF0176 protein A16_19190 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) A16_19270 ENOG4107RHR regulatoR A16_19290 ENOG4105D9N nucleoside A16_19300 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) A16_19370 ENOG4107RAQ aminopeptidase A16_19380 ENOG4107STQ Multicopper oxidase A16_19500 ENOG4108T5E Copper resistance protein A16_19510 ENOG4105KTB nuclear export factor GLE1 A16_19530 ENOG4107RT3 EamA-like transporter family A16_19540 ENOG4105GZI Transcriptional regulator A16_19550 ENOG4108Z40 Transcriptional regulator A16_19560 ENOG4107ZXU DSBA oxidoreductase A16_19570 ENOG4108TVJ Nitroreductase A16_19590 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A16_19600 ENOG4106F5Q Membrane A16_19610 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) A16_19630 ENOG4105CKI cobalamin synthesis protein A16_19670 ENOG4108Z7G MaoC domain protein dehydratase A16_19710 ENOG4105C0Z ABC transporter A16_19720 ENOG4108IV0 ABC, transporter A16_19730 ENOG4105C32 Amino acid ABC transporter (Permease) A16_19750 ENOG4105SKE transcriptional Regulator LysR family A16_19790 ENOG4105YGB Transcriptional regulator A16_19810 ENOG4105C4M (Ubiquinol oxidase) subunit I A16_19820 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii A16_19830 ENOG4108JJ9 ABC, transporter A16_19840 ENOG4108JJ8 (ABC) transporter A16_19920 ENOG4105BZ1 (ABC) transporter A16_19930 ENOG4105BZ1 (ABC) transporter A16_19940 ENOG4105EFI regulatoR A16_19950 ENOG4105BZU Histidine kinase A16_19990 ENOG41075D4 Aminoglycoside 6-adenylyltransferase A16_20000 ENOG4108ZJ4 polysaccharide deacetylase A16_20050 ENOG4105D6E homoserine dehydrogenase A16_20100 ENOG4108KGH TRANSCRIPTIONal A16_20120 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A16_20130 ENOG4105BZU Histidine kinase A16_20140 ENOG4107VMI polysaccharide deacetylase A16_20160 ENOG4105KT7 mgtC SapB transporter A16_20170 ENOG4105VRR gCN5-related N-acetyltransferase A16_20190 ENOG4105DUU IucA IucC family protein A16_20200 ENOG4105CEY Amp-dependent synthetase and ligase A16_20230 ENOG4108WBH protein TIM barrel A16_20240 ENOG4105YWU small acid-soluble spore protein A16_20280 ENOG4108ZUB Lysine exporter protein (Lyse ygga) A16_20400 ENOG4105KRN Transcriptional regulator, abrb family A16_20420 ENOG4105YVS arsR family transcriptional regulator A16_20430 ENOG4107SET aldo keto reductase A16_20440 ENOG4107XZQ multidrug resistance protein A16_20490 ENOG4105C8Q Methyl-accepting chemotaxis A16_20520 ENOG4108K88 Membrane A16_20530 ENOG4108WPJ Ferritin-like domain A16_20560 ENOG4105DEN Luciferase family A16_20600 ENOG4107QM2 Aldo Keto reductase A16_20610 ENOG4105CKI cobalamin synthesis protein A16_20710 ENOG4105DSE periplasmic solute binding protein A16_20730 ENOG4105K4T epimerase A16_20750 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A16_20800 ENOG4105CVJ phosphoglycerate mutase A16_20840 ENOG4107T5V SNARE associated Golgi A16_20870 ENOG4108PJD permease A16_20890 ENOG4108S4H thioesterase Superfamily protein A16_20950 ENOG4105SXS Protein of unknown function (DUF456) A16_20960 ENOG4105C37 (CBS) domain A16_21000 ENOG4108Z7R Chaperone CsaA A16_21030 ENOG4108ZRV stage ii sporulation protein p A16_21050 ENOG4108VXD carboxy-peptidase A16_21070 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A16_21120 ENOG4108X4Q Hydrolase A16_21140 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A16_21150 ENOG4107RBS Methyltransferase A16_21180 ENOG41087PP glycosyltransferase MGT family A16_21190 ENOG4108JYZ YitT family A16_21200 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A16_21270 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) A16_21360 ENOG4105KBJ sporulation protein ytfj A16_21410 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A16_21450 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) A16_21460 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase A16_21480 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein A16_21490 ENOG4105EMN RNA polymerase sigma factor A16_21540 ENOG4108V06 Glutathione peroxidase A16_21570 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A16_21610 ENOG4108IUE nitrate reductase beta subunit A16_21620 ENOG4105R3A Nitrate reductase A16_21670 ENOG4107V6Q Cyclic nucleotide-binding domain A16_21680 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A16_21690 ENOG4105D06 uba thif-type nad fad binding protein A16_21700 ENOG4105CVM Molybdenum cofactor synthesis domain protein A16_21710 ENOG4108ZAF Molybdopterin A16_21760 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein A16_21770 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein A16_21780 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A16_21790 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit A16_21800 ENOG4108IFG nitrite reductase, (NAD(P)H) A16_21810 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) A16_21900 ENOG4105MCT stage V sporulation protein S A16_21920 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A16_21970 ENOG4105C5H ABC transporter A16_22000 ENOG4108UUM single-stranded DNA-binding protein A16_22030 ENOG41061H0 Monooxygenase A16_22070 ENOG4107YX5 Pfam:DUF548 A16_22080 ENOG4105C75 arginyL-tRNA synthetase A16_22140 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) A16_22170 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) A16_22180 ENOG4105C5S asparaginyl-tRNA synthetase A16_22430 ENOG4105BZW Glycerate kinase A16_22440 ENOG4107QPK )-transporter A16_22450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A16_22460 ENOG41062D9 Histidine kinase A16_22490 ENOG4105C8J )-transporter A16_22530 ENOG4107XGZ Hydrolase A16_22540 ENOG4105CY2 Citrate transporter A16_22550 ENOG4105C0A alcohol dehydrogenase A16_22580 ENOG4105KD7 acetyltransferase A16_22710 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) A16_22740 ENOG4107RVG penicillin-binding protein A16_22750 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) A16_22760 ENOG4105E9Q Acyl-transferase A16_22770 ENOG4108UT2 hemolysin iii A16_22790 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) A16_22810 ENOG4108RCR degv family A16_22820 ENOG4105E8R UPF0173 metal-dependent hydrolase A16_22840 ENOG4108KF3 Electron transport protein SCO1 SenC A16_22850 ENOG4107Y70 Heat shock protein A16_22860 ENOG4105CAQ asparagine synthetase A16_22900 ENOG4108MES Periplasmic binding protein A16_22910 ENOG4105F0I Aminotransferase A16_22990 ENOG4105D8X mechanosensitive ion channel A16_23000 ENOG4105BZU Histidine kinase A16_23010 ENOG4105WH1 Two component transcriptional regulator luxr family A16_23030 ENOG4106KNT transcriptional regulator A16_23110 ENOG4105CMG Carbohydrate kinase A16_23120 ENOG4105CMG Carbohydrate kinase A16_23180 ENOG4108IJ8 ABC transporter A16_23190 ENOG4105E90 ABC transporter A16_23260 ENOG4105C37 (CBS) domain A16_23320 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A16_23350 ENOG4107S4Y M20 DapE family protein YgeY A16_23360 ENOG4108TSC N-acetyltransferase A16_23370 ENOG4108JUB Transcriptional regulator A16_23380 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein A16_23460 ENOG4108N23 SpoOM-related protein A16_23470 ENOG410841Q phosphoesterase PA-phosphatase related protein A16_23520 ENOG4108IBT Inherit from COG: transposase A16_23710 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A16_23780 ENOG4105BZ4 penicillin-binding protein A16_23790 ENOG4105CZM Major Facilitator A16_23810 ENOG4105W8X HesB YadR YfhF-family protein A16_23830 ENOG4105DXD 2-methylcitrate dehydratase A16_23840 ENOG4105CR4 methylisocitrate lyase A16_23860 ENOG4105C1G acyl-Coa dehydrogenase A16_23870 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase A16_23890 ENOG4105N14 lysine exporter protein LysE YggA A16_23900 ENOG4105E39 Enoyl-CoA hydratase A16_23930 ENOG4107RFY SbcCD D subunit A16_23940 ENOG4105EYH Exonuclease A16_24000 ENOG4105FCD Major Facilitator A16_24010 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase A16_24020 ENOG4105E4F Isochorismate synthase A16_24030 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase A16_24040 ENOG4105WQI isochorismatase A16_24050 ENOG4105CEY Amp-dependent synthetase and ligase A16_24060 ENOG4105WQT MbtH domain protein A16_24070 ENOG4105C0R drug resistance transporter emrb qaca subfamily A16_24100 ENOG4105K70 DNA-binding protein A16_24140 ENOG4105BZG amino acid carrier protein A16_24180 ENOG4105FE9 pseudouridine synthase A16_24200 ENOG4105C22 threonyL-tRNA synthetase A16_24240 ENOG4107SKW Inherit from COG: Alpha beta hydrolase A16_24300 ENOG4108D32 Methyltransferase A16_24360 ENOG41081I9 integral membrane protein A16_24380 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) A16_24400 ENOG4105EYF MMPL domain protein A16_24450 ENOG4105WCN acetyltransferase A16_24510 ENOG4105C1Q protoporphyrinogen oxidase A16_24530 ENOG41068WN A16_24550 ENOG4105VEQ Cold shock protein A16_24600 ENOG410667J hydrolase A16_24670 ENOG4107V2S Transcriptional regulator A16_24680 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) A16_24710 ENOG4105DND Transcriptional regulator A16_24720 ENOG4108RPX mosc domain containing protein A16_24750 ENOG4105BZ1 (ABC) transporter A16_24760 ENOG4105BZ1 (ABC) transporter A16_24790 ENOG4108JCI Transcriptional regulator A16_24850 ENOG4108KPJ rna polymerase sigma factor A16_24910 ENOG4105F32 YngK protein A16_24970 ENOG4105RD7 BadF BadG BcrA BcrD A16_24990 ENOG4107STF Involved in phosphonate degradation (By similarity) A16_25010 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) A16_25040 ENOG4105C1J atp-dependent rna helicase A16_25080 ENOG4108RZE Tetr family transcriptional regulator A16_25120 ENOG41088CC tellurite resistance protein tehB A16_25140 ENOG4108I0C methyltransferase A16_25150 ENOG4107RA9 decarboxylase A16_25160 ENOG41090HR transcriptional regulator A16_25250 ENOG4105CIN aminoacyl-histidine dipeptidase A16_25310 ENOG4107RF6 penicillin-binding protein A16_25360 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase A16_25370 ENOG4105ETE Transcriptional regulator (LacI family A16_25380 ENOG4105IE8 Alpha-ketoglutarate permease A16_25390 ENOG4105CK5 oxidoreductase A16_25460 ENOG4105D2N Aldolase A16_25470 ENOG4105DH8 myo-inositol catabolism A16_25510 ENOG4105CGH 5'-nucleotidase A16_25530 ENOG4105CGH 5'-nucleotidase A16_25560 ENOG4105VZ8 Transcriptional regulator A16_25580 ENOG4108VXD carboxy-peptidase A16_25630 ENOG41067SE Tetr family transcriptional regulator A16_25640 ENOG4105C5H ABC transporter A16_25660 ENOG4105BZU Histidine kinase A16_25690 ENOG4106ANW SMI1_KNR4 A16_25700 ENOG4105CEP NADH dehydrogenase A16_25710 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) A16_25740 ENOG4105CJ1 ABC, transporter A16_25760 ENOG4107Z3H Transcriptional regulator, TetR family A16_25790 ENOG4105C1G acyl-Coa dehydrogenase A16_25800 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A16_25810 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit A16_25820 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase A16_25830 ENOG4105E39 Enoyl-CoA hydratase A16_25840 ENOG4107QX3 carboxylase A16_25850 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A16_25870 ENOG4105WCN acetyltransferase A16_25880 ENOG4105DBI uridine monophosphokinase A16_25910 ENOG4105DZ1 carboxypeptidase A16_25940 ENOG4105T9C HD domain A16_25960 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) A16_26060 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) A16_26060 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) A16_26090 ENOG4105FQP Beta-lactamase A16_26110 ENOG4107Y80 Major Facilitator superfamily A16_26150 ENOG4105CUV Homoserine Kinase A16_26220 ENOG4105CPQ Dehydrogenase A16_26250 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) A16_26260 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) A16_26470 ENOG4105ETU transcriptional activator (TenA A16_26710 ENOG410667J hydrolase A16_26730 ENOG4105BZU Histidine kinase A16_26740 ENOG4107RF6 penicillin-binding protein A16_26780 ENOG4108JJB ABC transporter A16_26810 ENOG4108HGU Histidine kinase A16_26840 ENOG4105CB2 alcohol dehydrogenase A16_26850 ENOG4105CJN penicillin-binding protein A16_26870 ENOG4105FQP Beta-lactamase A16_26940 ENOG4108V4B ThiJ pfpI A16_26990 ENOG4107Y80 Major Facilitator superfamily A16_27020 ENOG4107VXM glycerophosphoryl diester phosphodiesterase A16_27070 ENOG4107Y9U Membrane A16_27150 ENOG4105FCD Major Facilitator A16_27180 ENOG4105E09 nadh pyrophosphatase A16_27190 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A16_27200 ENOG4108Z4K mutator MutT protein A16_27270 ENOG4108XI2 Domain of unknown function (DUF1963) A16_27330 ENOG4105KWG Pfam:DUF1696 A16_27410 ENOG4105PKS Excinuclease abc c subunit domain protein A16_27560 ENOG4105PAD Hydrolase A16_27610 ENOG4105DY8 decarboxylase A16_27650 ENOG4108IUM Glycogen debranching enzyme A16_27700 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) A16_27720 ENOG4105FDR Membrane A16_27790 ENOG4108V3A UPF0421 protein A16_27830 ENOG4105MSI germination protein ypeb A16_27870 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) A16_27880 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) A16_27890 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) A16_27900 ENOG4107Z3H Transcriptional regulator, TetR family A16_27960 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family A16_28000 ENOG4105E98 transcriptional regulator DeoR family A16_28040 ENOG41062ES Transcriptional regulator A16_28090 ENOG4107QKR Dehydrogenase A16_28110 ENOG4107RUY (E1 component), alpha subunit A16_28130 ENOG4105E1F short-chain dehydrogenase reductase A16_28140 ENOG4105RHY Pfam:UPF0157 A16_28190 ENOG4107SQ8 Glycine betaine A16_28200 ENOG4108IJ7 Glycine betaine A16_28250 ENOG4105E66 phosphoriboisomerase A A16_28260 ENOG41082BV acetyltransferase A16_28270 ENOG4108M1A Chitin-binding protein A16_28370 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 A16_28480 ENOG4105EEM helicase A16_28520 ENOG4105C9U ATP-dependent DNA helicase RecQ A16_28600 ENOG4108M1A Chitin-binding protein A16_28630 ENOG4105BZG amino acid carrier protein A16_28640 ENOG4105C26 Dehydrogenase A16_28650 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A16_28660 ENOG4105CTU Proline racemase A16_28670 ENOG4105CTU Proline racemase A16_28680 ENOG41080HI glycine oxidase A16_28760 ENOG4107T5V SNARE associated Golgi A16_28790 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD A16_28800 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) A16_28830 ENOG4105DTQ mandelate racemase muconate lactonizing A16_28910 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) A16_28920 ENOG4105BZU Histidine kinase A16_28930 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A16_29030 ENOG4105EPR degv family A16_29110 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) A16_29120 ENOG4106K7D Major facilitator family transporter A16_29170 ENOG4107BMA Transglycosylase associated protein A16_29200 ENOG41089UC methyltransferase, type 11 A16_29280 ENOG4105CHM Aminotransferase A16_29360 ENOG4105DVE abc transporter atp-binding protein A16_29430 ENOG4105C02 permease A16_29450 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) A16_29460 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component A16_29470 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein A16_29520 ENOG4105E09 nadh pyrophosphatase A16_29560 ENOG4108AQF aminoglycoside N(3)-acetyltransferase A16_29660 ENOG4107VC0 DNA alkylation repair enzyme A16_29690 ENOG4107VMI polysaccharide deacetylase A16_29710 ENOG4108ZCF integral membrane protein A16_29720 ENOG4105E0M Sulfatase A16_29740 ENOG4105C5H ABC transporter A16_29760 ENOG4105EYF MMPL domain protein A16_29770 ENOG4105EYF MMPL domain protein A16_29780 ENOG4105EYF MMPL domain protein A16_29790 ENOG41082JN Transcriptional regulator A16_29830 ENOG4105CIH Imidazole acetol-phosphate transaminase A16_29840 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase A16_29850 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase A16_29930 ENOG41069ER domain protein A16_29950 ENOG4105EMN RNA polymerase sigma factor A16_30000 ENOG4105D4B ABC, transporter A16_30030 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane A16_30050 ENOG4105DKT Transcriptional regulator A16_30090 ENOG41061GT Aldolase A16_30140 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) A16_30200 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) A16_30210 ENOG4105II7 pyrroline-5-carboxylate reductase A16_30230 ENOG4107258 Transcriptional regulator A16_30250 ENOG4105E0Y RtcB Protein A16_30270 ENOG4105G6Z alkaline phosphatase A16_30290 ENOG4105VMP Transcriptional regulator A16_30320 ENOG41090T1 Membrane A16_30370 ENOG41068WN A16_30420 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A16_30520 ENOG4105CKK Glycosyl transferase, family 2 A16_30550 ENOG4105C8Y Acetylornithine aminotransferase A16_30670 ENOG4108TVJ Nitroreductase A16_30680 ENOG4105FS7 Transcriptional regulator A16_30770 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family A16_30800 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) A16_30860 ENOG4108XET gCN5-related N-acetyltransferase A16_31030 ENOG410635A Membrane A16_31040 ENOG4105KNA -acetyltransferase A16_31050 ENOG4108IQI permease A16_31070 ENOG4105F1N DNA alkylation repair A16_31160 ENOG4107RF6 penicillin-binding protein A16_31180 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) A16_31260 ENOG4105P4J Allophanate hydrolase, subunit 1 A16_31270 ENOG4107258 Transcriptional regulator A16_31290 ENOG4106N3A copper homeostasis protein cutc A16_31300 ENOG4108ZRV stage ii sporulation protein p A16_31310 ENOG4108ZHR arsR family transcriptional regulator A16_31330 ENOG4105FDT acyl-CoA dehydrogenase A16_31370 ENOG4105DWD nucleoside recognition domain protein A16_31430 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) A16_31580 ENOG4105E2A Dehydrogenase A16_31610 ENOG4108IJ0 Aspartate ammonia-lyase A16_31620 ENOG4105HDK L-asparaginase A16_31630 ENOG4108IMY Transcriptional regulator A16_31650 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) A16_31660 ENOG4105CUB amino acid A16_31710 ENOG4105C6K Malic enzyme A16_31740 ENOG4108NHD germination protein A16_31750 ENOG4108NHD germination protein A16_31760 ENOG4108Q8B Spore germination protein A16_31820 ENOG4105CSV Glutaminase A16_31900 ENOG4105CGH 5'-nucleotidase A16_31910 ENOG4105CH6 catalase A16_31930 ENOG4105CHJ isochorismatase hydrolase A16_32070 ENOG4108606 TspO/MBR family A16_32080 ENOG4105CVP deoxyribo-dipyrimidine photolyase A16_32110 ENOG4108TWJ NADH dehydrogenase subunit 5 A16_32120 ENOG4105GPN Uncharacterized conserved protein (DUF2294) A16_32140 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase A16_32150 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) A16_32160 ENOG4105DSE periplasmic solute binding protein A16_32170 ENOG4105CC5 ABC transporter A16_32180 ENOG4105DIK (ABC) transporter A16_32240 ENOG4105D6J arsenicaL-resistance protein A16_32250 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase A16_32260 ENOG41085FC arsR family transcriptional regulator A16_32290 ENOG4105F7F Chaperone A16_32310 ENOG4105CHR reductase A16_32320 ENOG4108YXU transcriptional regulator AsnC family A16_32460 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) A16_32480 ENOG4105C0R drug resistance transporter emrb qaca subfamily A16_32500 ENOG4105IIP Membrane A16_32530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A16_32540 ENOG41062D9 Histidine kinase A16_32600 ENOG4105K6H D-cysteine desulfhydrase A16_32660 ENOG4105VZ8 Transcriptional regulator A16_32690 ENOG4108NNI Beta-lactamase domain-containing protein A16_32700 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase A16_32720 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) A16_32730 ENOG4105JQZ Methyltransferase A16_32760 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) A16_32780 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) A16_32810 ENOG4105BZU Histidine kinase A16_32840 ENOG4108U05 Transcriptional regulator A16_32880 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) A16_32890 ENOG4105DJB Major Facilitator Superfamily A16_32900 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) A16_32910 ENOG4107QR9 Iron-sulfur cluster binding protein A16_32930 ENOG4106P55 Transcriptional regulator A16_32950 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A A16_33010 ENOG4105TRI Hydrolase A16_33090 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) A16_33160 ENOG4107QJQ Mate efflux family protein A16_33200 ENOG4105EQ0 Major Facilitator superfamily A16_33210 ENOG4108JGH Tetr family transcriptional regulator A16_33230 ENOG4105C44 Serine transporter A16_33240 ENOG4105EJQ L-serine dehydratase A16_33270 ENOG4108JPW Aminotransferase A16_33300 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) A16_33320 ENOG4105DVH amino acid A16_33350 ENOG4108JQ1 Dehydrogenase A16_33400 ENOG4108AEY RNA polymerase sigma factor A16_33430 ENOG41082W1 Cupin 2, conserved barrel domain protein A16_33440 ENOG410874W AraC family transcriptional regulator A16_33480 ENOG4105HIR S-layer domain protein A16_33560 ENOG4108ISG Major Facilitator A16_33580 ENOG4107MII Sugar-specific transcriptional regulator TrmB A16_33590 ENOG4105CZM Major Facilitator A16_33630 ENOG4105DA5 (ABC) transporter A16_33640 ENOG41069JR A16_33670 ENOG4105RXJ A16_33680 ENOG4105KPY Small multidrug resistance protein A16_33690 ENOG4105KBX Transcriptional regulator, TetR family A16_33710 ENOG4105CRW Short chain fatty acid transporter A16_33730 ENOG4105DYS nad(p)h dehydrogenase (quinone) A16_33790 ENOG4108JJB ABC transporter A16_33800 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) A16_33850 ENOG4108K8S endonuclease I A16_33880 ENOG41067QW Transcriptional regulator A16_33900 ENOG4108Z66 YbaK ebsC protein A16_33910 ENOG4105CUT histidyl-tRNA synthetase A16_33940 ENOG4105KVH Transcriptional regulator A16_33950 ENOG4108RCM Nitroreductase A16_33990 ENOG4108PSK reductase A16_34010 ENOG4105CJ1 ABC, transporter A16_34130 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase A16_34140 ENOG4105DKQ ROK family A16_34150 ENOG4106UW1 Major Facilitator superfamily A16_34160 ENOG4108UW5 maltose o-acetyltransferase A16_34190 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) A16_34210 ENOG4105C31 Tryptophanyl-tRNA synthetase A16_34220 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) A16_34300 ENOG4105EV4 Multidrug resistance protein mdtH A16_34360 ENOG4105C37 (CBS) domain A16_34390 ENOG4105DDN Pentapeptide repeat-containing protein A16_34400 ENOG4105XDF Protein of unknown function (DUF1272) A16_34410 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) A16_34420 ENOG4105CMG Carbohydrate kinase A16_34430 ENOG4105C6Z Gluconate A16_34440 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) A16_34470 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase A16_34480 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase A16_34490 ENOG4105CIS alcohol dehydrogenase A16_34500 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone A16_34530 ENOG4105EWI Short-chain dehydrogenase reductase Sdr A16_34540 ENOG4105D4Y metalloprotease A16_34580 ENOG4105CV8 reductase A16_34590 ENOG4105F27 Major Facilitator A16_34620 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) A16_34630 ENOG4105C44 Serine transporter A16_34690 ENOG4105KVH Transcriptional regulator A16_34700 ENOG4108TZY GntR Family Transcriptional Regulator A16_34730 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase A16_34740 ENOG4105KVH Transcriptional regulator A16_34750 ENOG4105KVH Transcriptional regulator A16_34820 ENOG4105JAB phenazine biosynthesis protein, phzf family A16_34840 ENOG4105CHR reductase A16_34890 ENOG4105KVH Transcriptional regulator A16_35100 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) A16_35130 ENOG4107YXZ hydrolase, family 25 A16_35180 ENOG4105ED2 Beta-lactamase A16_35200 ENOG4105H3G oxidoreductase A16_35360 ENOG4108TN2 lmbE family A16_35380 ENOG4107R3E Citrate transporter A16_35430 ENOG4108MES Periplasmic binding protein A16_35450 ENOG4105EHG Permease protein A16_35460 ENOG4105DQ5 transport system permease protein A16_35470 ENOG4105NX3 Membrane A16_35480 ENOG4107ZY0 Phenazine biosynthesis-like protein A16_35520 ENOG4107CUJ Protein of unknown function (DUF2690) A16_35540 ENOG4107V2S Transcriptional regulator A16_35580 ENOG4105C98 muts2 protein A16_35610 ENOG4105E5K Alpha-amylase A16_35620 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase A16_35630 ENOG4105DPN Oligoendopeptidase f A16_35640 ENOG4108A04 Beta-lactamase A16_35700 ENOG4107VXM glycerophosphoryl diester phosphodiesterase A16_35740 ENOG41082BM Transcriptional regulator, arsr family A16_35750 ENOG4105CIS alcohol dehydrogenase A16_35810 ENOG4105RHY Pfam:UPF0157 A16_35820 ENOG4105C09 Bile acid A16_35830 ENOG4105CQB FAD linked oxidase domain protein A16_35870 ENOG4108UT6 Transferase hexapeptide repeat containing protein A16_35890 ENOG4105K64 Glycosyl transferase, family 2 A16_35900 ENOG4105E39 Enoyl-CoA hydratase A16_35920 ENOG4105KT7 mgtC SapB transporter A16_35940 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase A16_35950 ENOG41073R8 VanW family A16_35970 ENOG4108R1P A16_36010 ENOG4105VEQ Cold shock protein A16_36050 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) A16_36090 ENOG410904N short-chain dehydrogenase reductase A16_36110 ENOG4106IQC argininosuccinate lyase A16_36140 ENOG4108IA2 Sodium pantothenate symporter A16_36150 ENOG4105RG0 Membrane A16_36160 ENOG4105C26 Dehydrogenase A16_36170 ENOG4105CHR reductase A16_36190 ENOG4105EWU Squalene--hopene cyclase A16_36210 ENOG4105FR1 rard protein A16_36220 ENOG410696E Membrane A16_36250 ENOG4105D1F ATP-binding protein A16_36270 ENOG4108ZAF Molybdopterin A16_36280 ENOG4105CVM Molybdenum cofactor synthesis domain protein A16_36290 ENOG4105D06 uba thif-type nad fad binding protein A16_36300 ENOG4105TMB Formate nitrite transporter A16_36320 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) A16_36330 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) A16_36360 ENOG4108JB9 formate dehydrogenase A16_36380 ENOG4105E1K spore germination protein A16_36520 ENOG4107QJT sodium dicarboxylate symporter A16_36530 ENOG4108KGH TRANSCRIPTIONal A16_36550 ENOG4105EMN RNA polymerase sigma factor A16_36600 ENOG4105CIG ABC transporter A16_36620 ENOG4105D9R oxidoreductase A16_36640 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A16_36650 ENOG4105K4P CoA-binding domain protein A16_36660 ENOG4105C0H protease A16_36670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A16_36700 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase A16_36710 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) A16_36720 ENOG4105W8X HesB YadR YfhF-family protein A16_36780 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) A16_36800 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A16_36820 ENOG4108JJA ABC, transporter A16_36830 ENOG4108I0Z Aconitate hydratase A16_36890 ENOG4105E5W Transporter A16_36910 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A16_36950 ENOG4107F3J Amp-dependent synthetase and ligase A16_36960 ENOG4107ZYJ bioY protein A16_36970 ENOG4105CEY Amp-dependent synthetase and ligase A16_37060 ENOG4107AYK membrAne A16_37080 ENOG4105BZU Histidine kinase A16_37090 ENOG4105FBA Phospholipase Carboxylesterase A16_37100 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase A16_37110 ENOG4105CK7 Sodium proline symporter A16_37120 ENOG4105CBC glutamate synthase A16_37130 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A16_37140 ENOG4108VJ1 Transcriptional regulator (CarD family A16_37150 ENOG4108903 Formimidoylglutamase A16_37200 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) A16_37320 ENOG4107QIV Cytochrome c biogenesis protein A16_37340 ENOG4107RSM transcriptional regulator A16_37350 ENOG4105VAW lrga family A16_37360 ENOG41067MG lrgb family A16_37420 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A16_37450 ENOG4105BZ1 (ABC) transporter A16_37460 ENOG4105BZ1 (ABC) transporter A16_37500 ENOG4105D7V transposase A16_37530 ENOG4105D5T phosphonate abc transporter A16_37560 ENOG4105CGH 5'-nucleotidase A16_37580 ENOG4108SVB resolvase A16_37620 ENOG4105K7K Transcriptional regulator A16_37710 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase A16_37720 ENOG4105XSJ toxin secretion phage lysis holin A16_38160 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) A16_38370 ENOG4105C5F glutamine synthetase A16_38380 ENOG4105KV4 Transcriptional regulator A16_38390 ENOG4105CXI aluminum resistance protein A16_38420 ENOG4105EN6 Membrane A16_38430 ENOG4106F1P AAA ATPase, central domain protein A16_38490 ENOG41069ER domain protein A16_38500 ENOG4105DM4 PTS System A16_38510 ENOG4105DE4 1-phosphofructokinase A16_38520 ENOG4105E98 transcriptional regulator DeoR family A16_38550 ENOG4108SJC Membrane A16_38580 ENOG4105C85 amino acid A16_38620 ENOG4105TMB Formate nitrite transporter A16_38630 ENOG4105K70 DNA-binding protein A16_38640 ENOG4105C59 p-type ATPase A16_38650 ENOG410681U heavy metal transport detoxification protein A16_38660 ENOG4105VPX protein, conserved in bacteria A16_38680 ENOG4105NIV Esterase A16_38690 ENOG4105E0A ABC, transporter A16_38740 ENOG4105CGK Exodeoxyribonuclease III A16_38760 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A16_38770 ENOG4105D03 DNA-3-methyladenine glycosylase II A16_38840 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase A16_38850 ENOG4105BZU Histidine kinase A16_38900 ENOG41067MG lrgb family A16_38930 ENOG4107TTQ Alpha beta hydrolase fold A16_38940 ENOG4107YEI lmbE family A16_38990 ENOG4105F0V Cell wall hydrolase A16_39000 ENOG4107R6R udp-galactopyranose mutase A16_39010 ENOG4105E0M Sulfatase A16_39020 ENOG410890F Dynamin family A16_39040 ENOG4107QHE Choloylglycine hydrolase A16_39160 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A16_39170 ENOG4105DQU oxidoreductase, subunit beta A16_39180 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein A16_39190 ENOG4108IGT Dipeptidase A16_39200 ENOG4105MCT stage V sporulation protein S A16_39210 ENOG4105D48 metallophosphoesterase A16_39260 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase A16_39290 ENOG4105XZV Protein of unknown function (DUF3243) A16_39300 ENOG4108RKS Short-chain dehydrogenase reductase Sdr A16_39340 ENOG4105UIB (ABC) transporter A16_39350 ENOG4105UIB (ABC) transporter A16_39360 ENOG4108JQ9 ABC transporter A16_39370 ENOG4105DIH basic membrane A16_39380 ENOG4105FDP GntR family transcriptional regulator A16_39390 ENOG4107QZI cell division protein FtsK A16_39410 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit A16_39430 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A16_39450 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) A16_39460 ENOG4108S0H Dipicolinic acid synthetase, b subunit A16_39470 ENOG4105E35 Dipicolinate synthase subunit A A16_39490 ENOG4105C1V Peptidase, M16 A16_39530 ENOG4105DTN riboflavin biosynthesis protein ribF A16_39540 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) A16_39560 ENOG4105W7A Protein of unknown function (DUF503) A16_39580 ENOG4105VHM ribosomal protein A16_39590 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination A16_39600 ENOG4105CHV Transcription elongation factor NusA A16_39620 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) A16_39640 ENOG4105DZP Membrane-associated zinc metalloprotease A16_39650 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) A16_39660 ENOG4105KNE Phosphatidate cytidylyltransferase A16_39670 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) A16_39750 ENOG4108HE4 integrase family A16_39770 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) A16_39790 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha A16_39820 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) A16_39870 ENOG4105VB6 UPF0109 protein A16_39910 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) A16_39920 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) A16_39960 ENOG4105CHR reductase A16_39970 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase A16_40000 ENOG4105CB5 ATP-dependent DNA helicase recG A16_40010 ENOG4105DP4 dak2 domain fusion protein ylov A16_40020 ENOG4108ZAA Alkaline-shock protein A16_40040 ENOG4105FJ0 thiamine A16_40050 ENOG4105DJV ribulose-phosphate 3-epimerase A16_40060 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) A16_40070 ENOG4105D9P serine threonine protein kinase A16_40080 ENOG4108ZF3 Phosphatase A16_40100 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B A16_40120 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A16_40130 ENOG4105C25 Primosomal protein n' A16_40140 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase A16_40180 ENOG4105DSJ YicC domain protein A16_40200 ENOG4105F23 Fibronectin-binding protein A16_40210 ENOG4105DC7 peptidase M24 A16_40320 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain A16_40370 ENOG4105C34 Pseudouridine synthase A16_40400 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) A16_40420 ENOG4105DBK s4 domain protein A16_40430 ENOG41067XK integral membrane protein A16_40450 ENOG4105DFA alanine racemase domain protein A16_40460 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase A16_40470 ENOG4105WR5 sporulation protein, YlmC YmxH family A16_40490 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A16_40510 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) A16_40520 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) A16_40530 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) A16_40540 ENOG4105D4A Cell wall formation (By similarity) A16_40550 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) A16_40560 ENOG4105CNI cell division protein FtsW A16_40590 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) A16_40600 ENOG4105CJN penicillin-binding protein A16_40610 ENOG4105CJN penicillin-binding protein A16_40620 ENOG41068DC Essential cell division protein (By similarity) A16_40690 ENOG4105KNH Nucleic acid-binding protein A16_40800 ENOG4105XSJ toxin secretion phage lysis holin A16_40980 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A16_41000 ENOG4105CAR Terminase, large subunit A16_41170 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) A16_41200 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A16_41300 ENOG4108IMY Transcriptional regulator A16_41370 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) A16_41390 ENOG41063PX domain protein A16_41400 ENOG4105D78 K07001 NTE family protein A16_41410 ENOG4105H20 Sporulation integral membrane protein YlbJ A16_41430 ENOG4106H78 methyltransferase A16_41480 ENOG4107TB6 phosphoglycerate mutase A16_41510 ENOG4106UY4 Inherit from COG: Scp-like extracellular A16_41610 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) A16_41620 ENOG4105CNI cell division protein FtsW A16_41650 ENOG4108IAB Phoh family A16_41690 ENOG4105QA2 A16_41700 ENOG4105CI3 gtp-binding protein typa A16_41720 ENOG4105ECY inositol monophosphatase A16_41760 ENOG4105CXN decarboxylase A16_41840 ENOG4105C7S Dehydrogenase A16_41850 ENOG4105CPP Dehydrogenase, E1 component A16_41900 ENOG4108X4Q Hydrolase A16_41920 ENOG4105CN5 Metallo-Beta-Lactamase A16_41930 ENOG4107ZYR domain protein A16_42000 ENOG4108XRC Protein of unknown function (DUF458) A16_42020 ENOG4107IN1 Protein of unknown function (DUF1797) A16_42060 ENOG4105EPM Diguanylate phosphodiesterase A16_42070 ENOG4105K6S Short-chain dehydrogenase reductase Sdr A16_42100 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) A16_42120 ENOG4105UIN A16_42240 ENOG4108HGU Histidine kinase A16_42260 ENOG4105CHM Aminotransferase A16_42270 ENOG4105FKQ transcriptional regulator A16_42290 ENOG4105EG2 ABC transporter, permease A16_42310 ENOG4107FKK extracellular solute-binding protein family 1 A16_42330 ENOG4105CG3 alpha amylase, catalytic region A16_42410 ENOG4105CHU acetyl-coa acetyltransferase A16_42490 ENOG4105K7K Transcriptional regulator A16_42500 ENOG4105DTD Dehydrogenase A16_42520 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) A16_42540 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase A16_42590 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) A16_42640 ENOG4106TD9 Diguanylate cyclase A16_42680 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) A16_42710 ENOG4105CID antiterminator A16_42730 ENOG4105FDP GntR family transcriptional regulator A16_42750 ENOG4105CE4 GlcNAc 6-P deacetylase A16_42820 ENOG4107ZE5 PPIases accelerate the folding of proteins A16_42830 ENOG4105PTM secreted protein A16_42840 ENOG4105J7I hydrolase A16_42860 ENOG4105G6R Stage v sporulation protein ae A16_42880 ENOG4105CZ3 stage V sporulation protein ad A16_42890 ENOG41090VF Stage v sporulation protein ac A16_42930 ENOG4105C8J )-transporter A16_42940 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A16_42960 ENOG41082AN stage II sporulation protein A16_42970 ENOG4105DZ1 carboxypeptidase A16_42980 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family A16_42990 ENOG4105DVE abc transporter atp-binding protein A16_43050 ENOG4105D7N magnesium and cobalt transport protein CorA A16_43100 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A16_43120 ENOG4105I3K Ferric uptake regulator, Fur family A16_43130 ENOG4105MZ9 stage II sporulation protein m A16_43170 ENOG4105CPC Aldo Keto reductase A16_43190 ENOG4105RHY Pfam:UPF0157 A16_43230 ENOG4107SKW Inherit from COG: Alpha beta hydrolase A16_43250 ENOG4105ETE Transcriptional regulator (LacI family A16_43260 ENOG4108YM7 Gcn5-related n-acetyltransferase A16_43300 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) A16_43310 ENOG4108R6K riboflavin synthase, subunit alpha A16_43350 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) A16_43360 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) A16_43370 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) A16_43380 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) A16_43400 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A16_43440 ENOG4105DFD Na H antiporter A16_43450 ENOG4105CGH 5'-nucleotidase A16_43530 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) A16_43560 ENOG4108IXY short-chain dehydrogenase reductase A16_43570 ENOG41069FQ Metallo-beta-lactamase superfamily A16_43590 ENOG4105II7 pyrroline-5-carboxylate reductase A16_43600 ENOG4105EJQ L-serine dehydratase A16_43650 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) A16_43660 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) A16_43670 ENOG4105D9U N-acetyltransferase A16_43690 ENOG4108VZI ErfK ybiS ycfS ynhG family protein A16_43700 ENOG4108QEG Membrane A16_43710 ENOG4105CDA abc transporter atp-binding protein A16_43720 ENOG4105E5Q amino acid AbC transporter A16_43730 ENOG4108HW3 (ABC) transporter A16_43760 ENOG4105G7B Protein of unknown function (DUF2992) A16_43770 ENOG4105E09 nadh pyrophosphatase A16_43790 ENOG4105C7S Dehydrogenase A16_43800 ENOG4105CPP Dehydrogenase, E1 component A16_43840 ENOG4107RDP Dehydrogenase A16_43860 ENOG4108JUB Transcriptional regulator A16_43880 ENOG4108QXE glycerophosphoryl diester phosphodiesterase A16_43910 ENOG4107QQR Sporulation A16_43920 ENOG4105S1Z Stage IV sporulation protein B A16_43930 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) A16_43950 ENOG4105DX0 Hemolysin A A16_43970 ENOG4105CTB Polyprenyl synthetase A16_44020 ENOG4108ZSR alkaline shock protein A16_44030 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A16_44070 ENOG410644B Stage III sporulation protein af A16_44090 ENOG4105KQ4 Stage iii sporulation protein ad A16_44100 ENOG4108CQH stage III sporulation protein AC A16_44110 ENOG4105KR5 Stage iii sporulation protein A16_44120 ENOG4105CD2 stage iii sporulation protein aa A16_44170 ENOG4105DC7 peptidase M24 A16_44200 ENOG4105CBJ Metal-dependent enzyme A16_44220 ENOG4107YBY Hydrolase A16_44270 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) A16_44280 ENOG4105WZW rhodanese family A16_44320 ENOG41080TC multidrug resistance protein A16_44400 ENOG4105CJ1 ABC, transporter A16_44410 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family A16_44470 ENOG4105C0D helicase A16_44720 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) A16_44730 ENOG4105C3R Methionine synthase A16_44750 ENOG4105C28 cystathionine A16_44760 ENOG4105C28 cystathionine A16_44800 ENOG4105C5X domain protein A16_44820 ENOG4105DKQ ROK family A16_44840 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase A16_44870 ENOG4108UTW Plays a role in the regulation of phosphate uptake A16_44880 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) A16_44890 ENOG4105E2Z phosphate ABC transporter (Permease A16_44900 ENOG4105C8U phosphate abc transporter A16_44910 ENOG4105PWN phosphate abc transporter A16_44920 ENOG4107RF6 penicillin-binding protein A16_44940 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A16_44990 ENOG4105N80 Ferric uptake regulator, Fur family A16_45010 ENOG4105FDK ABC transporter A16_45020 ENOG4108JYZ YitT family A16_45090 ENOG4105EGD dinuclear metal center protein, YbgI family A16_45120 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A16_45130 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) A16_45200 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) A16_45210 ENOG4105KG3 cytidine deaminase A16_45220 ENOG4107YR5 Diacylglycerol kinase A16_45240 ENOG4105CTJ Metal Dependent Phosphohydrolase A16_45250 ENOG4105C9A Phoh family A16_45280 ENOG41068P3 sporulation protein YqfC A16_45290 ENOG4105KTH gatB Yqey A16_45310 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A16_45320 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) A16_45360 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ A16_45380 ENOG4105CSA Coproporphyrinogen iii oxidase A16_45390 ENOG4105KVH Transcriptional regulator A16_45440 ENOG4105TQK DNA polymerase iii, delta' subunit A16_45460 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 A16_45480 ENOG4108UK2 deaminase A16_45490 ENOG4105KQC Competence protein A16_45510 ENOG4105DXX methyltransferase A16_45530 ENOG4108WF2 Metal Dependent Phosphohydrolase A16_45570 ENOG4105CQW ribosome biogenesis GTPase YqeH A16_45580 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase A16_45610 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A16_45660 ENOG4108TVJ Nitroreductase A16_45700 ENOG4105G6Z alkaline phosphatase A16_45720 ENOG4108MUZ hydrolase A16_45830 ENOG4105MIR Phenylalanine 4-monooxygenase A16_45850 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase A16_45860 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase A16_45940 ENOG4105S6R Iron-hydroxamate transporter permease subunit A16_45950 ENOG4108V5C ABC transporter A16_45970 ENOG4108EKI Dehydrogenase A16_45980 ENOG4105C28 cystathionine A16_46040 ENOG4107XRG penicillin-binding protein A16_46070 ENOG4105CFP Peptidase U32 A16_46080 ENOG4105XYU peptidase (U32 family) A16_46090 ENOG4108VQJ O-methyltransferase A16_46100 ENOG4105HHA aminodeoxychorismate lyase A16_46140 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A16_46160 ENOG4105C02 permease A16_46190 ENOG41060CR A16_46200 ENOG4105C7H Helicase, RecD TraA family A16_46220 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) A16_46230 ENOG4105C3J Cysteine desulfurase A16_46250 ENOG4105D1H recombination factor protein RarA A16_46260 ENOG4108VCI transcription factor, rsfa family A16_46270 ENOG4105CUZ uba thif-type nad fad binding protein A16_46290 ENOG4105CUT histidyl-tRNA synthetase A16_46320 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) A16_46340 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) A16_46350 ENOG41076HS cation diffusion facilitator family transporter A16_46360 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) A16_46380 ENOG4105CKP Polysaccharide Biosynthesis Protein A16_46390 ENOG4108QG2 Membrane A16_46410 ENOG4105VIE preprotein translocase, subunit YajC A16_46440 ENOG41061AI Protein of unknown function (DUF2905) A16_46470 ENOG4108HUF Transporter A16_46490 ENOG4108IPJ Membrane A16_46500 ENOG4108IPJ Membrane A16_46510 ENOG41082BM Transcriptional regulator, arsr family A16_46560 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase A16_46570 ENOG4108IYU L-aspartate oxidase A16_46600 ENOG4108RPX mosc domain containing protein A16_46610 ENOG4105CQC Prephenate dehydratase A16_46650 ENOG4105EWM Histidine kinase A16_46680 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control A16_46710 ENOG4105X36 (ribosomal) protein A16_46730 ENOG4105C03 ribonuclease A16_46760 ENOG4107QMS site-determining protein A16_46790 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) A16_46800 ENOG4105DFF Rod shape-determining protein mreb A16_46840 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase A16_46850 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) A16_46870 ENOG41068KH stage VI sporulation protein D A16_46890 ENOG4105D52 delta-aminolevulinic acid dehydratase A16_46940 ENOG4105K56 Transcriptional regulator A16_46980 ENOG4108IUQ atp-dependent protease A16_47030 ENOG4108QCI YvbH-like oligomerisation region A16_47070 ENOG4105M59 Phosphodiesterase, mj0936 family A16_47080 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) A16_47100 ENOG4108XJQ germination protein A16_47120 ENOG4108PCX Major Facilitator A16_47150 ENOG4105KBX Transcriptional regulator, TetR family A16_47180 ENOG4105PFC Transcriptional regulator A16_47210 ENOG4105DZC cytosine deaminase A16_47220 ENOG4105DZC cytosine deaminase A16_47230 ENOG4105DEF Extracellular solute-binding protein, family 5 A16_47240 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A16_47270 ENOG4108JQ7 (ABC) transporter A16_47280 ENOG4108HRK Histidine kinase A16_47290 ENOG4105DY9 regulatoR A16_47320 ENOG41067S9 phage shock protein C, PspC A16_47330 ENOG4108JCI Transcriptional regulator A16_47350 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) A16_47360 ENOG4108Z40 Transcriptional regulator A16_47370 ENOG4105RHA ABC transporter, permease A16_47380 ENOG4108IUX (ABC) transporter A16_47390 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family A16_47420 ENOG4105E14 MotA TolQ exbB proton channel A16_47430 ENOG4108VXD carboxy-peptidase A16_47450 ENOG4105E33 succinate dehydrogenase A16_47470 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit A16_47500 ENOG4105K63 Thioredoxin A16_47510 ENOG4105C10 Electron transfer flavoprotein A16_47520 ENOG4105BZJ Electron transfer flavoprotein A16_47530 ENOG41060WC Enoyl-CoA hydratase A16_47540 ENOG4107Z3H Transcriptional regulator, TetR family A16_47550 ENOG4105CEY Amp-dependent synthetase and ligase A16_47580 ENOG4105J76 Periplasmic binding protein A16_47590 ENOG4105S6R Iron-hydroxamate transporter permease subunit A16_47680 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A16_47710 ENOG4105DR4 Methyltransferase A16_47740 ENOG4105KFN sortase, SrtB family A16_47750 ENOG4105E0A ABC, transporter A16_47780 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) A16_47800 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) A16_47820 ENOG4105FE9 pseudouridine synthase A16_47840 ENOG4105DCG PHP domain protein A16_47950 ENOG4108RWN rrna methyltransferase A16_48020 ENOG4105C0R drug resistance transporter emrb qaca subfamily A16_48030 ENOG4105CW7 secretion protein, HlyD family A16_48040 ENOG4108JGH Tetr family transcriptional regulator A16_48050 ENOG4105CN9 Peptidase m42 family protein A16_48110 ENOG4105C22 threonyL-tRNA synthetase A16_48120 ENOG4108TDW sporulation protein YtxC A16_48160 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) A16_48180 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase A16_48190 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) A16_48230 ENOG4105C2M dna polymerase I A16_48240 ENOG4105BZU Histidine kinase A16_48250 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A16_48300 ENOG4108HMX isocitrate dehydrogenase (NADP) A16_48310 ENOG4105BZN citrate synthase A16_48340 ENOG4108REF Sporulation integral membrane protein ytvi A16_48350 ENOG4105FS0 cytoplasmic membrane protein A16_48400 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family A16_48410 ENOG4105C6K Malic enzyme A16_48420 ENOG4105C0B DNA polymerase III (alpha subunit) A16_48430 ENOG4105VV2 A16_48450 ENOG4105SFS phosphoesterase RecJ domain protein A16_48530 ENOG4105DC7 peptidase M24 A16_48600 ENOG4105Z7P Acetyltransferase (GNAT) family A16_48610 ENOG41082W1 Cupin 2, conserved barrel domain protein A16_48630 ENOG4105VZ8 Transcriptional regulator A16_48670 ENOG4107YZX Universal stress protein A16_48760 ENOG4108JYZ YitT family A16_48800 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) A16_48820 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) A16_48830 ENOG4105KBJ sporulation protein ytfj A16_48860 ENOG4105EFZ amidohydrolase A16_48880 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A16_48940 ENOG4106KR7 LysR family Transcriptional regulator A16_48990 ENOG4105C28 cystathionine A16_49030 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) A16_49050 ENOG4105EMN RNA polymerase sigma factor A16_49080 ENOG4105F1V Acetoin utilization protein A16_49090 ENOG4105W87 Cbs domain A16_49100 ENOG4105DGU Histone deacetylase A16_49120 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A16_49140 ENOG4107SNB ankyrin repeat protein YahD A16_49150 ENOG4105EP9 oxidoreductase A16_49210 ENOG4105ETE Transcriptional regulator (LacI family A16_49250 ENOG4105C88 aminopeptidase A16_49350 ENOG4108VDD TRNA binding domain protein A16_49410 ENOG4105C8F Beta-lactamase domain protein A16_49440 ENOG4108V15 phosphotransferase enzyme family A16_49450 ENOG4108IUM Glycogen debranching enzyme A16_49470 ENOG4107QSE Dipeptidase A16_49480 ENOG4107QSE Dipeptidase A16_49490 ENOG4105YW5 deoR family transcriptional regulator A16_49520 ENOG4105CBX hi0933 family A16_49600 ENOG4108VJ1 Transcriptional regulator (CarD family A16_49610 ENOG4107EXU Short-chain dehydrogenase reductase Sdr A16_49620 ENOG4105CSC Glucose uptake protein A16_49650 ENOG4108ZAF Molybdopterin A16_49660 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein A16_49670 ENOG4105CVM Molybdenum cofactor synthesis domain protein A16_49690 ENOG4105D06 uba thif-type nad fad binding protein A16_49750 ENOG41085GJ domain protein A16_49770 ENOG4105DWV Homoserine O-trans-acetylase A16_49810 ENOG4108B31 Spore germination protein A16_49880 ENOG410605W Major Facilitator A16_49890 ENOG4107S91 Sodium hydrogen exchanger A16_49900 ENOG4105NCW Trka-c domain protein A16_49940 ENOG4105C19 ABC transporter A16_49980 ENOG4105N5T Radical SAM Protein A16_50000 ENOG4105DA5 (ABC) transporter A16_50070 ENOG4105E8V Alpha Beta Hydrolase Fold protein A16_50080 ENOG4108Z0R Transferase A16_50090 ENOG4105YVM Phosphoesterase, PA-phosphatase related A16_50100 ENOG4105BZF Glycosyl transferase (Group 1 A16_50120 ENOG4108RIR Molybdenum cofactor biosynthesis protein A16_50220 ENOG4105EGD dinuclear metal center protein, YbgI family A16_50230 ENOG4105BZU Histidine kinase A16_50240 ENOG4105BZU Histidine kinase A16_50250 ENOG4107S9D Alpha beta hydrolase A16_50300 ENOG4105D2X ABC transporter substrate-binding protein A16_50320 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component A16_50430 ENOG4108V2W Carbonate dehydratase A16_50440 ENOG4105C4M (Ubiquinol oxidase) subunit I A16_50450 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii A16_50540 ENOG41087YS Phage shock protein A A16_50600 ENOG4105BZU Histidine kinase A16_50610 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A16_50660 ENOG4108UGV hypoxanthine phosphoribosyltransferase A16_50670 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) A16_50740 ENOG4107ZTW SNARE associated Golgi A16_50770 ENOG4105C19 ABC transporter A16_50780 ENOG41086D8 Transcriptional regulator A16_50890 ENOG4105C6Z Gluconate A16_50900 ENOG4105FDP GntR family transcriptional regulator A16_50940 ENOG41069H0 dihydroorotase EC 3.5.2.3 A16_51020 ENOG4105DTQ mandelate racemase muconate lactonizing A16_51040 ENOG4108IPT Naphthoate synthase A16_51070 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) A16_51080 ENOG4105E4F Isochorismate synthase A16_51090 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase A16_51110 ENOG4105VEQ Cold shock protein A16_51160 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) A16_51180 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) A16_51200 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) A16_51390 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation A16_51460 ENOG4105KT7 mgtC SapB transporter A16_51470 ENOG4107PBV potassium channel A16_51490 ENOG4107QYV phosphohexose isomerase A16_51500 ENOG4105WG9 Conserved Protein A16_51520 ENOG4105CHM Aminotransferase A16_51530 ENOG4108ZB6 transcriptional regulator AsnC family A16_51540 ENOG4105C5I Dehydrogenase A16_51550 ENOG4108MUZ hydrolase A16_51570 ENOG4105C87 Aminotransferase class I and II A16_51600 ENOG4105Y38 Kinase-associated protein B A16_51620 ENOG4107R3E Citrate transporter A16_51660 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) A16_51670 ENOG4105KA0 thioesterase Superfamily protein A16_51710 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase A16_51760 ENOG41069ER domain protein A16_51790 ENOG4105CEP NADH dehydrogenase A16_51850 ENOG4105EWC Purine nucleoside phosphorylase A16_51890 ENOG4108YX9 iron--sulfur cluster insertion protein erpA A16_51940 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) A16_51950 ENOG4105C4B ABC transporter, permease A16_51960 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA A16_52050 ENOG41083MR nifu domain-containing protein A16_52080 ENOG4108W5N phosphatidylglycerophosphatase a A16_52100 ENOG4105DYS nad(p)h dehydrogenase (quinone) A16_52110 ENOG4105D4U had-superfamily hydrolase, subfamily iia A16_52140 ENOG4105CBT Fructose-1,6-bisphosphatase A16_52170 ENOG4105MMD transcriptional regulator A16_52180 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) A16_52190 ENOG4107TXC Transcriptional regulator A16_52200 ENOG41090T1 Membrane A16_52250 ENOG4105FAA peptidase M23 A16_52270 ENOG4105KZD Domain of unknown function (DUF1805) A16_52330 ENOG4105DIW FeS assembly protein SUFB A16_52340 ENOG4108UNV SUF system FeS assembly protein, NifU family A16_52350 ENOG4105C9B Cysteine desulfurase A16_52380 ENOG4105C3K feS assembly ATPase SufC A16_52390 ENOG4105D01 (LipO)protein A16_52400 ENOG4105D01 (LipO)protein A16_52410 ENOG4108UMI ABC transporter, permease A16_52480 ENOG41080E8 Transcriptional regulator, Spx MgsR family A16_52560 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) A16_52610 ENOG4108W8B Beta-lactamase domain protein A16_52620 ENOG4105C1G acyl-Coa dehydrogenase A16_52640 ENOG4105CHU acetyl-coa acetyltransferase A16_52670 ENOG4105DZ1 carboxypeptidase A16_52710 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer A16_52760 ENOG4108SUT Major Facilitator Superfamily A16_52770 ENOG4107R7I amino acid A16_52790 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins A16_52810 ENOG4107AYK membrAne A16_52880 ENOG4107ZTW SNARE associated Golgi A16_52900 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein A16_52910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A16_52920 ENOG4105BZU Histidine kinase A16_52940 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) A16_52970 ENOG4105VG1 fes assembly suf system protein A16_52980 ENOG4105D4Y metalloprotease A16_53020 ENOG4107S91 Sodium hydrogen exchanger A16_53030 ENOG4105NCW Trka-c domain protein A16_53050 ENOG4108RMU ferritin dps family protein A16_53090 ENOG4108URH decarboxylase A16_53140 ENOG4105D9N nucleoside A16_53150 ENOG4105D9N nucleoside A16_53180 ENOG4108RYK Nad-dependent epimerase dehydratase A16_53230 ENOG4105CV8 reductase A16_53240 ENOG4105F27 Major Facilitator A16_53250 ENOG4105KVH Transcriptional regulator A16_53280 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) A16_53290 ENOG4105D4A Cell wall formation (By similarity) A16_53310 ENOG4105C8Q Methyl-accepting chemotaxis A16_53330 ENOG4105WMR Protein CrcB homolog A16_53340 ENOG4105WMR Protein CrcB homolog A16_53370 ENOG4108MK9 spermidine N(1)-acetyltransferase A16_53380 ENOG4108VY7 phosphate-starvation-inducible protein PsiE A16_53410 ENOG4108IPW abc transporter atp-binding protein A16_53420 ENOG4105CM4 permease protein A16_53480 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) A16_53500 ENOG4105XZU Preprotein translocase, subunit SecG A16_53510 ENOG41067MG lrgb family A16_53710 ENOG4105EFC phage portal protein HK97 family A16_53760 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A16_53780 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) A16_53790 ENOG4105CP7 Triose-phosphate isomerase A16_53840 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A16_53880 ENOG41090VF Stage v sporulation protein ac A16_53890 ENOG4105CZ3 stage V sporulation protein ad A16_53920 ENOG4105H67 Protein of unknown function (DUF421) A16_53930 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A16_53940 ENOG4105KRI phosphocarrier protein (HPr A16_53960 ENOG4105CHW UPF0052 protein A16_53980 ENOG4108Z4K mutator MutT protein A16_54000 ENOG4105C3M thioredoxin reductase A16_54020 ENOG4108S4C acetyltransferase A16_54060 ENOG41086DT Membrane protein of unknown function A16_54080 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) A16_54090 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) A16_54100 ENOG4105D7V transposase A16_54130 ENOG4107TXC Transcriptional regulator A16_54180 ENOG4105HMI Membrane A16_54190 ENOG4105DUM transcriptional regulator, lysR family A16_54210 ENOG4108WS4 fmn reductase A16_54240 ENOG4105BZ1 (ABC) transporter A16_54260 ENOG4105CN1 protease A16_54270 ENOG4105CRP Part of the ABC transporter FtsEX involved in A16_54280 ENOG4105CAK Cell division ATP-binding protein ftsE A16_54310 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) A16_54340 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving A16_54350 ENOG4105MS2 ribosomal subunit Interface protein A16_54370 ENOG4105VEQ Cold shock protein A16_54380 ENOG41081UC Inherit from COG: Competence protein A16_54420 ENOG4105KVH Transcriptional regulator A16_54440 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein A16_54450 ENOG4108KGH TRANSCRIPTIONal A16_54460 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase A16_54470 ENOG4105C6Y Udp-glucose 6-dehydrogenase A16_54480 ENOG4105ESV Glycosyl transferase, family 4 A16_54500 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A16_54530 ENOG410901P UPF0249 protein A16_54540 ENOG4105F8D glycoside hydrolase family 4 A16_54550 ENOG4105VCP PTS System A16_54560 ENOG4105CK1 PTS System A16_54580 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) A16_54590 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) A16_54600 ENOG4105VCP PTS System A16_54620 ENOG4105VZJ PTS System A16_54650 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase A16_54660 ENOG4105ECB domain protein A16_54670 ENOG4107RSM transcriptional regulator A16_54770 ENOG4105DAA L-lactate A16_54790 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) A16_54810 ENOG4105E0M Sulfatase A16_54910 ENOG4105C94 Transporter A16_54920 ENOG41069ER domain protein A16_54970 ENOG4105KBK Zinc finger, swim domain protein A16_54980 ENOG4105C0D helicase A16_55040 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A16_55060 ENOG4107RBB ABC transporter, permease A16_55070 ENOG4105C19 ABC transporter A16_55110 ENOG4105CXY transporter A16_55140 ENOG4105BZU Histidine kinase A16_55150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A16_55160 ENOG4105CMR udp-glucose 4-epimerase A16_55200 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase A16_55210 ENOG4105EY8 ABC transporter A16_55350 ENOG4105FRN stage II sporulation protein A16_55380 ENOG4105DY9 regulatoR A16_55390 ENOG4108IUW ABC transporter A16_55430 ENOG4106778 Protein of unknown function (DUF1146) A16_55440 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A16_55450 ENOG4105C8S subunit m A16_55460 ENOG4105D65 subunit l A16_55510 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A16_55520 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain A16_55540 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain A16_55550 ENOG4105BZU Histidine kinase A16_55650 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) A16_55660 ENOG41062M3 atp synthase A16_55720 ENOG4108YZG isomerase A16_55750 ENOG4108VGI doxx family A16_55760 ENOG4107XC4 flavin reductase domain protein, FMN-binding A16_55790 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A16_55810 ENOG4108ZXQ stage ii sporulation protein r A16_55820 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) A16_55830 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) A16_55860 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) A16_55870 ENOG4105CBT Fructose-1,6-bisphosphatase A16_55880 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) A16_55950 ENOG4105C1G acyl-Coa dehydrogenase A16_55960 ENOG4105C1G acyl-Coa dehydrogenase A16_55970 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase A16_55990 ENOG4105DF6 Fe-S oxidoreductase A16_56020 ENOG4105BZU Histidine kinase A16_56070 ENOG4105BZU Histidine kinase A16_56080 ENOG4105KCT ABC transporter A16_56090 ENOG4108M15 ABC transporter A16_56100 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) A16_56160 ENOG4105IIU Aminopeptidase A16_56200 ENOG4105EMN RNA polymerase sigma factor A16_56230 ENOG410684U Domain of unknown function (DUF1934) A16_56280 ENOG4105CYW agmatinase A16_56300 ENOG4105DXB Major Facilitator superfamily A16_56310 ENOG4107SWG transcriptional regulator MERR family A16_56330 ENOG4108QXE glycerophosphoryl diester phosphodiesterase A16_56340 ENOG4105BZ4 penicillin-binding protein A16_56350 ENOG4108XFG YwhD family A16_56360 ENOG4108Z4T Peptidase M50 A16_56370 ENOG41069HH 4-oxalocrotonate tautomerase A16_56380 ENOG4105DCI Phosphohydrolase A16_56390 ENOG4108MES Periplasmic binding protein A16_56400 ENOG4105E0A ABC, transporter A16_56410 ENOG4105EHG Permease protein A16_56430 ENOG4105DQ5 transport system permease protein A16_56450 ENOG4108VCI transcription factor, rsfa family A16_56480 ENOG4108IJ2 phosphate acetyltransferase A16_56510 ENOG4108VKI Cell wall hydrolase A16_56580 ENOG410667J hydrolase A16_56590 ENOG4105VCH membrane A16_56610 ENOG4108TU7 Inherit from COG: (ABC) transporter A16_56620 ENOG4105CJ1 ABC, transporter A16_56630 ENOG41090WU lipolytic protein G-D-S-L family A16_56660 ENOG4105D6E homoserine dehydrogenase A16_56710 ENOG4108Y4K DNA-binding transcriptional activator A16_56730 ENOG4105WH1 Two component transcriptional regulator luxr family A16_56760 ENOG4105DWF phosphomethylpyrimidine kinase A16_56770 ENOG4105BZU Histidine kinase A16_56780 ENOG4105VCD cytoplasmic protein A16_56790 ENOG4105D22 carbon starvation protein A16_56800 ENOG4105DY9 regulatoR A16_56820 ENOG41079KZ Major Facilitator Superfamily A16_56860 ENOG4105EN6 Membrane A16_56870 ENOG4106YBV Methyl-accepting chemotaxis A16_56890 ENOG4108S4H thioesterase Superfamily protein A16_56910 ENOG4105JEU Glycosyl transferase, family 2 A16_56920 ENOG4105C5H ABC transporter A16_56980 ENOG4105CKK Glycosyl transferase, family 2 A16_56990 ENOG41067SE Tetr family transcriptional regulator A16_57010 ENOG4105E0X reductase A16_57030 ENOG4106F5Q Membrane A16_57060 ENOG4105DY9 regulatoR A16_57070 ENOG4108HRK Histidine kinase A16_57080 ENOG4107RGD Major Facilitator superfamily A16_57110 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A16_57130 ENOG4105IW1 AmiS UreI transporter A16_57150 ENOG4105CMR udp-glucose 4-epimerase A16_57160 ENOG4108UT2 hemolysin iii A16_57180 ENOG4105C1J atp-dependent rna helicase A16_57210 ENOG4105DPN Oligoendopeptidase f A16_57250 ENOG4105C0H protease A16_57260 ENOG4105Q2H domain protein A16_57300 ENOG4105BZU Histidine kinase A16_57310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A16_57370 ENOG4105CDU Replicative dna helicase A16_57390 ENOG4105BZR domain protein A16_57400 ENOG4108XMW Membrane A16_57420 ENOG4108UUM single-stranded DNA-binding protein A16_57440 ENOG4105C3G gtp-binding protein A16_57450 ENOG4105VDK protein, conserved in bacteria A16_57460 ENOG4105D8X mechanosensitive ion channel A16_57470 ENOG4108ZDA Sporulation protein YyaC A16_57480 ENOG4105FA0 parb-like partition protein A16_57490 ENOG4107QJE Chromosome Partitioning Protein A16_57530 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) A16_57550 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins A16_57600 ENOG4107U5W ybbr family A16_57685 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) A16_57710 ENOG4108IMY Transcriptional regulator A16_57750 ENOG4107QQG Dehydrogenase A16_57790 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase A16_57795 ENOG4105DMQ Methyltransferase A16_57800 ENOG4107T89 von Willebrand factor, type A A16_57805 ENOG4107414 GntR family transcriptional regulator A16_57815 ENOG4105ETE Transcriptional regulator (LacI family A16_57820 ENOG4108IQI permease A16_57985 ENOG4108JQ7 (ABC) transporter A16_58030 ENOG4105CZN Potassium uptake protein A16_58240 ENOG4105F6J Alpha beta hydrolase fold A16_58275 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) A16_58395 ENOG4105EC2 ftsk spoIIIe A16_58415 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 A16_58445 ENOG4105SZ6 Thioredoxin A16_58665 ENOG4108NRW Phospholipase, patatin family A16_58680 ENOG4107VFR oxidoreductase A16_58815 ENOG4105ECK Fatty Acid Desaturase A16_58820 ENOG4108WCX response regulator A16_58840 ENOG4105CKK Glycosyl transferase, family 2 A16_58860 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A16_58885 ENOG4105II7 pyrroline-5-carboxylate reductase A16_59020 ENOG4105DMQ Methyltransferase A16_59065 ENOG4105KAF membrAne A16_59175 ENOG4105DA5 (ABC) transporter A16_59245 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A16_59355 ENOG41069ZM Protein of unknown function (DUF2624) A16_59375 ENOG410812S Rna-binding protein A16_59385 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin A16_59425 ENOG4105C5S asparaginyl-tRNA synthetase A16_59430 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) A16_59435 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) A16_59440 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) A16_59530 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) A16_59565 ENOG4107R8B 5'-nucleotidase A16_59575 ENOG4105JRK feS assembly protein SufD A16_59660 ENOG4105MT0 Sporulation transcriptional regulator spoiiid A16_59670 ENOG4105DQ5 transport system permease protein A16_59740 ENOG4105EKQ RNA-directed DNA polymerase A16_59820 ENOG4105EKQ RNA-directed DNA polymerase A16_59940 ENOG4105CNU cell division protein FtsK A16_60165 ENOG4105DHF Membrane A16_60190 ENOG4106AKK s-layer domain-containing protein A16_60195 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase A16_60220 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase A16_60225 ENOG4105C6Y Udp-glucose 6-dehydrogenase A16_60240 ENOG4105DQ6 Transposase A16_60280 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) A16_60395 ENOG4105KRN Transcriptional regulator, abrb family A16_60405 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A16_60435 ENOG4108IBT Inherit from COG: transposase A16_60445 ENOG4105DQ6 Transposase A16_60465 ENOG4108MEK Metal-binding protein YodA A16_60475 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) A16_60505 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) A16_60585 ENOG4105K4H Nlp p60 protein A16_60730 ENOG4107QJE Chromosome Partitioning Protein A16_60750 ENOG4105DQ6 Transposase A16_60775 ENOG4105EWC Purine nucleoside phosphorylase A16_60850 ENOG4105C3F Signal peptidase i A16_60880 ENOG4105N14 lysine exporter protein LysE YggA A16_60915 ENOG4108J59 Extracellular solute-binding protein, family 5 A16_60930 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) A16_60990 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) A16_60995 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)