locus-tag	class	description
A16_00020	COG0592	DNA-directed DNA polymerase activity
A16_00030	COG2501	S4 domain
A16_00050	COG0187	DNA topoisomerase II activity
A16_00060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A16_00110	COG0516	GMP reductase activity
A16_00110	COG0517	IMP dehydrogenase activity
A16_00120	COG1686	Belongs to the peptidase S11 family
A16_00180	COG1428	Deoxynucleoside kinase
A16_00190	COG1428	Deoxynucleoside kinase
A16_00200	COG1335	isochorismatase
A16_00210	COG0590	tRNA wobble adenosine to inosine editing
A16_00220	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A16_00330	COG1982	Orn Lys Arg decarboxylase major
A16_00350	COG0470	DNA polymerase III
A16_00360	COG1774	PSP1 C-terminal conserved region
A16_00380	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A16_00400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A16_00410	COG2002	toxin-antitoxin pair type II binding
A16_00420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A16_00420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A16_00430	COG0084	hydrolase, TatD family'
A16_00440	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A16_00470	COG4466	Protein conserved in bacteria
A16_00500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A16_00520	COG0251	oxidation-reduction process
A16_00550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A16_00560	COG0193	aminoacyl-tRNA hydrolase activity
A16_00580	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A16_00590	COG2002	toxin-antitoxin pair type II binding
A16_00600	COG2244	polysaccharide biosynthetic process
A16_00610	COG3956	TIGRFAM MazG family protein
A16_00620	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A16_00660	COG1098	S1 RNA binding domain
A16_00690	COG2208	phosphoserine phosphatase activity
A16_00700	COG0037	tRNA processing
A16_00720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A16_00750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A16_00760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A16_00770	COG0512	Glutamine amidotransferase of anthranilate synthase
A16_00780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A16_00790	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A16_00800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A16_00810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A16_00820	COG1396	sequence-specific DNA binding
A16_00830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A16_00890	COG3880	PFAM UvrB UvrC protein
A16_00930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A16_00950	COG4956	integral membrane protein (PIN domain superfamily)
A16_00990	COG1045	serine acetyltransferase
A16_01020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A16_01030	COG3688	RNA-binding protein containing a PIN domain
A16_01050	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A16_01060	COG0250	Participates in transcription elongation, termination and antitermination
A16_01110	COG2813	Specifically methylates the guanine in position
A16_01140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A16_01150	COG1358	cellular component organization or biogenesis
A16_01360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A16_01410	COG0201	protein transport
A16_01430	COG0024	Methionine aminopeptidase
A16_01450	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A16_01510	COG1122	ATPase activity
A16_01520	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A16_01530	COG0101	tRNA pseudouridine synthase activity
A16_01570	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16_01580	COG0489	protein tyrosine kinase activity
A16_01600	COG2194	sulfuric ester hydrolase activity
A16_01610	COG0726	polysaccharide deacetylase
A16_01780	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A16_01820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A16_01830	COG0596	Alpha beta hydrolase
A16_01880	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A16_01890	COG0823	Involved in the tonB-independent uptake of proteins
A16_01890	COG1506	peptidase
A16_01890	COG4946	Tricorn protease homolog
A16_01970	COG1028	Short-chain dehydrogenase reductase Sdr
A16_01980	COG2011	ABC-type metal ion transport system permease component
A16_01990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A16_02000	COG1464	Belongs to the NlpA lipoprotein family
A16_02030	COG0277	FAD linked oxidase domain protein
A16_02040	COG2271	Major facilitator Superfamily
A16_02060	COG2814	Major facilitator Superfamily
A16_02090	COG0601	transmembrane transport
A16_02100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A16_02110	COG0444	Belongs to the ABC transporter superfamily
A16_02120	COG4608	Belongs to the ABC transporter superfamily
A16_02130	COG4166	transmembrane transport
A16_02150	COG2207	Transcriptional regulator
A16_02180	COG4166	transmembrane transport
A16_02190	COG4166	transmembrane transport
A16_02200	COG0656	L-ascorbic acid biosynthetic process
A16_02210	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16_02240	COG4149	molybdate abc transporter
A16_02250	COG0725	ABC transporter, periplasmic molybdate-binding protein
A16_02260	COG0725	ABC transporter, periplasmic molybdate-binding protein
A16_02270	COG1910	domain protein
A16_02280	COG0583	DNA-binding transcription factor activity
A16_02290	COG0697	spore germination
A16_02310	COG0204	Acyl-transferase
A16_02330	COG1609	Transcriptional regulator
A16_02350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_02380	COG0084	hydrolase, TatD family'
A16_02390	COG5298	Protein conserved in bacteria
A16_02440	COG0488	(ABC) transporter
A16_02480	COG0747	negative chemotaxis
A16_02490	COG0601	transmembrane transport
A16_02510	COG0444	Belongs to the ABC transporter superfamily
A16_02520	COG4608	Belongs to the ABC transporter superfamily
A16_02570	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A16_02580	COG0179	Fumarylacetoacetate (FAA) hydrolase
A16_02600	COG2814	Major facilitator Superfamily
A16_02630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A16_02650	COG4294	response to UV
A16_02660	COG0457	Tetratricopeptide repeat
A16_02660	COG0705	Rhomboid family
A16_02680	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A16_02690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A16_02700	COG0864	Transcriptional regulator
A16_02710	COG2337	Toxic component of a toxin-antitoxin (TA) module
A16_02720	COG2183	response to ionizing radiation
A16_02900	COG0802	atpase or kinase
A16_02910	COG1214	PFAM Peptidase M22, glycoprotease
A16_02920	COG0456	acetyltransferase
A16_02930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A16_02940	COG0488	(ABC) transporter
A16_02970	COG1266	CAAX protease self-immunity
A16_03010	COG2252	PERMEase
A16_03030	COG5002	protein histidine kinase activity
A16_03090	COG2226	methyltransferase
A16_03180	COG1968	undecaprenyl-diphosphatase activity
A16_03210	COG2205	protein histidine kinase activity
A16_03220	COG0745	RESPONSE REGULATOR receiver
A16_03260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A16_03270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A16_03280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A16_03300	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A16_03330	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A16_03350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A16_03370	COG0151	Belongs to the GarS family
A16_03420	COG0210	DNA helicase
A16_03440	COG4851	CamS sex pheromone cAM373 precursor
A16_03480	COG1335	isochorismatase
A16_03490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A16_03500	COG2011	ABC-type metal ion transport system permease component
A16_03510	COG1464	Belongs to the NlpA lipoprotein family
A16_03550	COG1846	Transcriptional regulator
A16_03600	COG1597	lipid kinase activity
A16_03610	COG0546	phosphoglycolate phosphatase activity
A16_03620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A16_03640	COG1012	belongs to the aldehyde dehydrogenase family
A16_03650	COG2076	Multidrug Resistance protein
A16_03660	COG2309	aminopeptidase activity
A16_03690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16_03700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A16_03710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A16_03730	COG4807	Protein conserved in bacteria
A16_03790	COG1473	amidohydrolase
A16_03820	COG0450	alkyl hydroperoxide reductase
A16_03860	COG0235	Class ii aldolase
A16_03870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_03880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_03890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_03920	COG0166	Belongs to the GPI family
A16_03990	COG5002	protein histidine kinase activity
A16_04030	COG3541	Predicted nucleotidyltransferase
A16_04040	COG2814	Major facilitator Superfamily
A16_04050	COG0723	plastoquinol--plastocyanin reductase activity
A16_04050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A16_04070	COG0765	amino acid transport
A16_04080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16_04100	COG0840	transmembrane signaling receptor activity
A16_04110	COG0840	transmembrane signaling receptor activity
A16_04120	COG0366	Alpha amylase catalytic
A16_04130	COG2190	(PTS) system
A16_04130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16_04130	COG1263	PTS System
A16_04200	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A16_04230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A16_04250	COG1116	anion transmembrane transporter activity
A16_04260	COG0488	(ABC) transporter
A16_04350	COG2270	Major facilitator Superfamily
A16_04380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A16_04410	COG2310	stress, protein
A16_04420	COG2310	stress, protein
A16_04430	COG2310	stress, protein
A16_04440	COG0861	Integral membrane protein TerC family
A16_04460	COG3853	Toxic anion resistance protein (TelA)
A16_04490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A16_04510	COG1295	ribonuclease BN
A16_04520	COG2217	Heavy metal translocating P-type atpase
A16_04530	COG0697	spore germination
A16_04580	COG0586	Pfam SNARE associated Golgi protein
A16_04610	COG3871	stress protein (general stress protein 26)
A16_04620	COG0387	Pfam Sodium calcium exchanger
A16_04640	COG0535	radical SAM domain protein
A16_04690	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A16_04700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A16_04710	COG0582	viral genome integration into host DNA
A16_04760	COG1396	sequence-specific DNA binding
A16_04830	COG1484	DNA-dependent DNA replication
A16_05000	COG0582	viral genome integration into host DNA
A16_05270	COG0101	tRNA pseudouridine synthase activity
A16_05290	COG3829	transcription factor binding
A16_05310	COG0833	amino acid
A16_05320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A16_05370	COG2066	Belongs to the glutaminase family
A16_05390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16_05390	COG1263	PTS System
A16_05400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16_05430	COG0463	Glycosyl transferase, family 2
A16_05460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A16_05460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A16_05490	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A16_05530	COG1228	amidohydrolase
A16_05540	COG1090	epimerase
A16_05600	COG1988	membrane-bound metal-dependent
A16_05610	COG1194	a g-specific adenine glycosylase
A16_05680	COG1132	(ABC) transporter
A16_05690	COG4129	membrane
A16_05700	COG0069	glutamate synthase activity
A16_05700	COG0067	glutamate synthase
A16_05700	COG0070	glutamate synthase
A16_05720	COG4555	ABC transporter
A16_05760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A16_05770	COG0735	belongs to the Fur family
A16_06000	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A16_06010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A16_06030	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A16_06050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A16_06070	COG2766	serine protein kinase
A16_06110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A16_06130	COG1585	Membrane protein implicated in regulation of membrane protease activity
A16_06140	COG2268	Band 7 protein
A16_06160	COG3290	protein histidine kinase activity
A16_06190	COG2851	Citrate transporter
A16_06230	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A16_06240	COG3842	ATPase activity
A16_06250	COG1175	transmembrane transport
A16_06260	COG0395	ABC-type sugar transport system, permease component
A16_06280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A16_06290	COG0745	RESPONSE REGULATOR receiver
A16_06300	COG5002	protein histidine kinase activity
A16_06320	COG4990	cell redox homeostasis
A16_06340	COG3290	protein histidine kinase activity
A16_06350	COG4565	transcriptional regulatory protein
A16_06360	COG3493	citrate carrier protein
A16_06370	COG0281	malic enzyme
A16_06400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16_06420	COG5002	protein histidine kinase activity
A16_06430	COG0745	RESPONSE REGULATOR receiver
A16_06450	COG0454	-acetyltransferase
A16_06450	COG0456	acetyltransferase
A16_06460	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A16_06470	COG3383	formate dehydrogenase (NAD+) activity
A16_06490	COG2427	Protein of unknown function (DUF1641)
A16_06520	COG0531	amino acid
A16_06530	COG0640	Transcriptional regulator
A16_06540	COG2217	Heavy metal translocating P-type atpase
A16_06550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A16_06580	COG3227	Zinc metalloprotease (Elastase)
A16_06630	COG2720	vancomycin resistance protein
A16_06640	COG1316	TRANSCRIPTIONal
A16_06650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16_06670	COG1253	flavin adenine dinucleotide binding
A16_06680	COG1027	Aspartate ammonia-lyase
A16_06690	COG1620	l-lactate permease
A16_06720	COG3104	oligopeptide transport
A16_06730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_06740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_06750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_06790	COG0156	8-amino-7-oxononanoate synthase activity
A16_06800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A16_06840	COG0714	Associated with various cellular activities
A16_06850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A16_06890	COG0531	amino acid
A16_06910	COG1263	PTS System
A16_06910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16_06930	COG0366	Alpha amylase catalytic
A16_06960	COG0697	spore germination
A16_06980	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A16_06990	COG1115	amino acid carrier protein
A16_07000	COG1126	abc transporter atp-binding protein
A16_07010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16_07020	COG0765	amino acid transport
A16_07030	COG0765	amino acid transport
A16_07040	COG0833	amino acid
A16_07090	COG2378	regulation of single-species biofilm formation
A16_07100	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A16_07110	COG5002	protein histidine kinase activity
A16_07150	COG0659	secondary active sulfate transmembrane transporter activity
A16_07180	COG0747	negative chemotaxis
A16_07200	COG0601	transmembrane transport
A16_07210	COG4608	Belongs to the ABC transporter superfamily
A16_07230	COG2271	Major facilitator Superfamily
A16_07240	COG1846	Transcriptional regulator
A16_07250	COG0477	Major facilitator Superfamily
A16_07260	COG0477	Major facilitator Superfamily
A16_07290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A16_07310	COG1129	ABC transporter
A16_07320	COG1172	Belongs to the binding-protein-dependent transport system permease family
A16_07330	COG1879	ABC-type sugar transport system periplasmic component
A16_07340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A16_07380	COG1063	alcohol dehydrogenase
A16_07410	COG3568	Endonuclease Exonuclease Phosphatase
A16_07460	COG1968	undecaprenyl-diphosphatase activity
A16_07470	COG0840	transmembrane signaling receptor activity
A16_07480	COG3584	3D domain protein
A16_07480	COG1388	LysM domain
A16_07490	COG1476	TRANSCRIPTIONal
A16_07520	COG3104	oligopeptide transport
A16_07530	COG1114	Component of the transport system for branched-chain amino acids
A16_07560	COG1113	amino acid transport
A16_07570	COG2252	PERMEase
A16_07620	COG0569	domain protein
A16_07620	COG0475	glutathione-regulated potassium exporter activity
A16_07650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A16_07660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A16_07670	COG4990	cell redox homeostasis
A16_07700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A16_07710	COG0697	spore germination
A16_07720	COG0531	amino acid
A16_07750	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A16_07760	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A16_07770	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A16_07770	COG1918	ferrous iron import across plasma membrane
A16_07780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A16_07790	COG0573	inorganic phosphate transmembrane transporter activity
A16_07800	COG0581	inorganic phosphate transmembrane transporter activity
A16_07820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A16_08050	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A16_08100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A16_08110	COG1116	anion transmembrane transporter activity
A16_08120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A16_08130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A16_08140	COG0352	thiamine-phosphate diphosphorylase activity
A16_08150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A16_08160	COG2104	thiamine diphosphate biosynthetic process
A16_08180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A16_08190	COG0351	phosphomethylpyrimidine kinase
A16_08260	COG2205	protein histidine kinase activity
A16_08270	COG2814	Major facilitator Superfamily
A16_08280	COG1846	Transcriptional regulator
A16_08310	COG2252	PERMEase
A16_08320	COG1028	Short-chain dehydrogenase reductase Sdr
A16_08360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A16_08370	COG1621	beta-fructofuranosidase activity
A16_08380	COG1263	PTS System
A16_08380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16_08390	COG1609	Transcriptional regulator
A16_08410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16_08420	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A16_08510	COG0778	Nitroreductase
A16_08520	COG2719	SpoVR family
A16_08580	COG0446	pyridine nucleotide-disulphide oxidoreductase
A16_08590	COG1937	Protein conserved in bacteria
A16_08600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16_08600	COG0425	Belongs to the sulfur carrier protein TusA family
A16_08610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_08610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16_08620	COG0425	Belongs to the sulfur carrier protein TusA family
A16_08630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16_08650	COG2210	Belongs to the sulfur carrier protein TusA family
A16_08660	COG0730	response to heat
A16_08680	COG1316	TRANSCRIPTIONal
A16_08690	COG0604	alcohol dehydrogenase
A16_08700	COG1283	sodium-dependent phosphate transmembrane transporter activity
A16_08740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A16_08740	COG3711	transcriptional antiterminator
A16_08750	COG1447	Phosphotransferase system cellobiose-specific component IIA
A16_08760	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A16_08800	COG1388	LysM domain
A16_08800	COG3584	3D domain protein
A16_08810	COG0577	efflux transmembrane transporter activity
A16_08820	COG1136	(ABC) transporter
A16_08840	COG5522	Integral membrane protein (intg_mem_TP0381)
A16_08880	COG1114	Component of the transport system for branched-chain amino acids
A16_08890	COG3546	catalase activity
A16_08960	COG0586	Pfam SNARE associated Golgi protein
A16_09030	COG0531	amino acid
A16_09040	COG0475	glutathione-regulated potassium exporter activity
A16_09060	COG1737	Transcriptional regulator
A16_09080	COG1263	PTS System
A16_09080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16_09100	COG2259	Doxx family
A16_09130	COG0697	spore germination
A16_09140	COG1522	sequence-specific DNA binding
A16_09160	COG2076	Multidrug Resistance protein
A16_09170	COG2076	Multidrug Resistance protein
A16_09180	COG1309	transcriptional regulator
A16_09190	COG2814	Major facilitator Superfamily
A16_09200	COG1733	regulation of RNA biosynthetic process
A16_09220	COG2249	NAD(P)H dehydrogenase (quinone) activity
A16_09230	COG4533	DNA binding
A16_09240	COG2211	Major facilitator Superfamily
A16_09260	COG0693	protein deglycase activity
A16_09270	COG0693	protein deglycase activity
A16_09270	COG0753	catalase activity
A16_09300	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A16_09320	COG1012	belongs to the aldehyde dehydrogenase family
A16_09330	COG1132	(ABC) transporter
A16_09360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16_09370	COG0765	amino acid transport
A16_09380	COG1126	abc transporter atp-binding protein
A16_09410	COG0189	ligase activity
A16_09470	COG0028	Belongs to the TPP enzyme family
A16_09480	COG3527	Alpha-acetolactate decarboxylase
A16_09510	COG0561	phosphatase activity
A16_09550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A16_09580	COG0659	secondary active sulfate transmembrane transporter activity
A16_09630	COG0653	protein targeting
A16_09640	COG2244	polysaccharide biosynthetic process
A16_09660	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16_09670	COG4196	transglutaminase domain protein
A16_09700	COG1696	Membrane protein involved in D-alanine export
A16_09730	COG1024	Enoyl-CoA hydratase
A16_09760	COG1363	Peptidase, m42
A16_09800	COG3938	Belongs to the proline racemase family
A16_09880	COG0601	transmembrane transport
A16_09890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A16_09920	COG4608	Belongs to the ABC transporter superfamily
A16_09980	COG0477	Major facilitator Superfamily
A16_09990	COG3290	protein histidine kinase activity
A16_10000	COG4565	transcriptional regulatory protein
A16_10010	COG3181	Tripartite tricarboxylate transporter family receptor
A16_10080	COG4978	Transcriptional regulator
A16_10080	COG0789	Transcriptional regulator
A16_10110	COG0305	Participates in initiation and elongation during chromosome replication
A16_10180	COG0477	Major facilitator Superfamily
A16_10270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A16_10270	COG3320	Male sterility
A16_10320	COG1183	phosphatidylcholine synthase activity
A16_10360	COG2376	Dihydroxyacetone kinase
A16_10380	COG2376	Dihydroxyacetone kinase
A16_10390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A16_10400	COG1959	2 iron, 2 sulfur cluster binding
A16_10470	COG3437	response regulator, receiver
A16_10470	COG2770	Histidine kinase
A16_10560	COG3237	CsbD-like
A16_10610	COG1191	sigma factor activity
A16_10630	COG2208	phosphoserine phosphatase activity
A16_10640	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A16_10650	COG2198	Histidine kinase
A16_10650	COG2205	protein histidine kinase activity
A16_10650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16_10650	COG0784	Response regulator, receiver
A16_10700	COG0393	Putative heavy-metal-binding
A16_10770	COG0420	3'-5' exonuclease activity
A16_10780	COG4717	serine-type aminopeptidase activity
A16_10820	COG1309	transcriptional regulator
A16_10830	COG2814	Major facilitator Superfamily
A16_10840	COG0346	lactoylglutathione lyase activity
A16_10850	COG0346	lactoylglutathione lyase activity
A16_10860	COG0457	Tetratricopeptide repeat
A16_10880	COG2267	carboxylic ester hydrolase activity
A16_10920	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A16_10930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A16_10950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A16_11030	COG0477	Major facilitator Superfamily
A16_11040	COG0477	Major facilitator Superfamily
A16_11060	COG3973	AAA domain
A16_11070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A16_11110	COG4980	gas vesicle protein
A16_11120	COG0537	adenosine 5'-monophosphoramidase activity
A16_11130	COG1131	(ABC) transporter
A16_11140	COG4473	ABC transporter
A16_11170	COG1309	transcriptional regulator
A16_11190	COG3402	PFAM membrane-flanked domain
A16_11210	COG3428	Bacterial PH domain
A16_11290	COG3402	PFAM membrane-flanked domain
A16_11300	COG3428	Bacterial PH domain
A16_11310	COG2329	Antibiotic biosynthesis monooxygenase
A16_11320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16_11330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A16_11420	COG1309	transcriptional regulator
A16_11430	COG1511	domain protein
A16_11480	COG1609	Transcriptional regulator
A16_11500	COG1234	tRNA 3'-trailer cleavage
A16_11510	COG0095	Lipoate-protein ligase
A16_11530	COG0318	PFAM AMP-dependent synthetase and ligase
A16_11590	COG3209	COG3209 Rhs family protein
A16_11690	COG1408	metallophosphoesterase
A16_11700	COG1078	dGTPase activity
A16_11720	COG1595	DNA-templated transcription, initiation
A16_11730	COG2207	Transcriptional regulator
A16_11730	COG3708	Transcriptional regulator
A16_11760	COG2205	protein histidine kinase activity
A16_11770	COG0745	RESPONSE REGULATOR receiver
A16_11820	COG0501	Belongs to the peptidase M48B family
A16_11830	COG0840	transmembrane signaling receptor activity
A16_11840	COG0697	spore germination
A16_11880	COG0497	DNA recombination
A16_11890	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A16_11900	COG2224	Isocitrate lyase
A16_11920	COG1278	Cold shock
A16_11950	COG4903	ComK protein
A16_11960	COG0398	Pfam SNARE associated Golgi protein
A16_11980	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A16_11990	COG1074	ATP-dependent DNA helicase activity
A16_12070	COG0179	Fumarylacetoacetate (FAA) hydrolase
A16_12120	COG0367	asparagine synthase
A16_12140	COG0753	catalase activity
A16_12150	COG0004	ammonium transporteR
A16_12190	COG2996	Protein conserved in bacteria
A16_12210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A16_12230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_12260	COG0561	phosphatase activity
A16_12290	COG0542	response to heat
A16_12310	COG2267	carboxylic ester hydrolase activity
A16_12340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16_12350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A16_12360	COG5504	Zn-dependent protease
A16_12380	COG0180	Tryptophanyl-tRNA synthetase
A16_12400	COG4166	transmembrane transport
A16_12410	COG0601	transmembrane transport
A16_12420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A16_12430	COG0444	Belongs to the ABC transporter superfamily
A16_12460	COG0534	Mate efflux family protein
A16_12470	COG4166	transmembrane transport
A16_12500	COG1393	Belongs to the ArsC family
A16_12510	COG0861	Integral membrane protein TerC family
A16_12520	COG4862	establishment of competence for transformation
A16_12530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A16_12550	COG1164	Oligoendopeptidase f
A16_12580	COG2346	COG2346, Truncated hemoglobins
A16_12590	COG4116	CYTH
A16_12610	COG2357	RelA SpoT domain protein
A16_12620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A16_12630	COG0564	pseudouridine synthase activity
A16_12700	COG1216	Glycosyl transferase, family 2
A16_12750	COG0457	Tetratricopeptide repeat
A16_12750	COG0463	Glycosyl transferase, family 2
A16_12790	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A16_12820	COG1091	dTDP-4-dehydrorhamnose reductase activity
A16_12910	COG2153	protein acetylation
A16_12920	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A16_12930	COG2382	esterase
A16_12960	COG5492	domain, Protein
A16_12970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A16_13000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A16_13000	COG0512	Glutamine amidotransferase of anthranilate synthase
A16_13070	COG1620	l-lactate permease
A16_13080	COG5634	Uncharacterized conserved protein (DUF2278)
A16_13180	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16_13200	COG1476	TRANSCRIPTIONal
A16_13300	COG2226	methyltransferase
A16_13320	COG1686	Belongs to the peptidase S11 family
A16_13330	COG0681	Belongs to the peptidase S26 family
A16_13400	COG1012	belongs to the aldehyde dehydrogenase family
A16_13410	COG3842	ATPase activity
A16_13420	COG1176	ABC-type spermidine putrescine transport system, permease component I
A16_13430	COG1177	transmembrane transport
A16_13440	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A16_13460	COG2409	Drug exporters of the RND superfamily
A16_13480	COG0564	pseudouridine synthase activity
A16_13500	COG2340	Cysteine-rich secretory protein family
A16_13510	COG0247	lactate metabolic process
A16_13520	COG0277	FAD linked oxidase domain protein
A16_13530	COG3835	regulator
A16_13550	COG0745	RESPONSE REGULATOR receiver
A16_13560	COG5002	protein histidine kinase activity
A16_13570	COG2186	Transcriptional regulator
A16_13610	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A16_13640	COG2116	formate transmembrane transporter activity
A16_13650	COG0861	Integral membrane protein TerC family
A16_13690	COG2030	dehydratase
A16_13730	COG1028	Short-chain dehydrogenase reductase Sdr
A16_13770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A16_13800	COG1840	ABC-type Fe3 transport system, periplasmic component
A16_13840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A16_13870	COG1349	DNA-binding transcription factor activity
A16_13950	COG2861	carbohydrate metabolic process
A16_13970	COG3852	Histidine kinase
A16_13980	COG1846	Transcriptional regulator
A16_14000	COG2318	DinB family
A16_14020	COG5002	protein histidine kinase activity
A16_14040	COG0720	synthase
A16_14080	COG4873	Protein conserved in bacteria
A16_14140	COG1780	Probably involved in ribonucleotide reductase function
A16_14180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A16_14190	COG1725	Transcriptional regulator
A16_14200	COG1131	(ABC) transporter
A16_14220	COG1131	(ABC) transporter
A16_14230	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A16_14260	COG1522	sequence-specific DNA binding
A16_14280	COG1335	isochorismatase
A16_14300	COG1619	proteins homologs of microcin C7 resistance protein MccF
A16_14310	COG2070	2-Nitropropane dioxygenase
A16_14320	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A16_14340	COG1696	Membrane protein involved in D-alanine export
A16_14400	COG0716	FMN binding
A16_14430	COG3173	Aminoglycoside phosphotransferase
A16_14470	COG0534	Mate efflux family protein
A16_14480	COG1968	undecaprenyl-diphosphatase activity
A16_14510	COG1846	Transcriptional regulator
A16_14530	COG1301	dicarboxylic acid transport
A16_14540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A16_14550	COG4709	membrane
A16_14560	COG3874	Sporulation protein YtfJ
A16_14610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A16_14620	COG0028	Belongs to the TPP enzyme family
A16_14630	COG0440	acetolactate synthase activity
A16_14640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A16_14660	COG0473	3-isopropylmalate dehydrogenase activity
A16_14710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A16_14780	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A16_14810	COG1183	phosphatidylcholine synthase activity
A16_14830	COG1368	sulfuric ester hydrolase activity
A16_14850	COG0019	diaminopimelate decarboxylase activity
A16_14890	COG0529	Catalyzes the synthesis of activated sulfate
A16_14900	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A16_14940	COG1648	precorrin-2 dehydrogenase activity
A16_14950	COG0733	neurotransmitter:sodium symporter activity
A16_14990	COG1757	Na H antiporter
A16_15020	COG4758	membrane
A16_15030	COG4585	Histidine kinase
A16_15040	COG2197	response regulator
A16_15060	COG1114	Component of the transport system for branched-chain amino acids
A16_15070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A16_15120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A16_15120	COG1017	nitric oxide dioxygenase activity
A16_15150	COG0730	response to heat
A16_15160	COG0306	phosphate transporter
A16_15170	COG1392	Phosphate transport regulator
A16_15180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16_15220	COG3852	Histidine kinase
A16_15230	COG1801	Protein of unknown function DUF72
A16_15250	COG0582	viral genome integration into host DNA
A16_15260	COG5002	protein histidine kinase activity
A16_15300	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A16_15300	COG0392	lysyltransferase activity
A16_15330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A16_15340	COG1686	Belongs to the peptidase S11 family
A16_15350	COG2715	membrane protein required for spore maturation
A16_15360	COG0700	Nucleoside recognition
A16_15370	COG1187	pseudouridine synthase activity
A16_15390	COG1333	cytochrome c biogenesis protein
A16_15400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A16_15410	COG0745	RESPONSE REGULATOR receiver
A16_15420	COG5002	protein histidine kinase activity
A16_15430	COG2096	Adenosyltransferase
A16_15460	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A16_15470	COG1141	Ferredoxin
A16_15480	COG4955	Helix-turn-helix domain
A16_15490	COG0514	ATP-dependent DNA helicase (RecQ)
A16_15500	COG1266	CAAX protease self-immunity
A16_15550	COG4862	establishment of competence for transformation
A16_15560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A16_15600	COG0492	ferredoxin-NADP+ reductase activity
A16_15610	COG0252	asparaginase activity
A16_15740	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A16_15770	COG0142	geranyltranstransferase activity
A16_15790	COG0142	geranyltranstransferase activity
A16_15800	COG0105	UTP biosynthetic process
A16_15830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A16_15840	COG0457	Tetratricopeptide repeat
A16_15880	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A16_15900	COG4347	Protein of unknown function (DUF1405)
A16_15930	COG2738	Putative neutral zinc metallopeptidase
A16_15950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_15960	COG1694	Mazg nucleotide pyrophosphohydrolase
A16_15990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A16_16000	COG0438	transferase activity, transferring glycosyl groups
A16_16070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A16_16070	COG1199	ATP-dependent helicase activity
A16_16110	COG3935	DnaD domain protein
A16_16120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A16_16140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16_16140	COG4499	WXG100 protein secretion system (Wss), protein YukC
A16_16230	COG4474	Belongs to the UPF0398 family
A16_16250	COG0116	Belongs to the methyltransferase superfamily
A16_16270	COG1199	ATP-dependent helicase activity
A16_16280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A16_16300	COG3173	Aminoglycoside phosphotransferase
A16_16310	COG0024	Methionine aminopeptidase
A16_16340	COG2233	PERMEase
A16_16350	COG2311	Membrane
A16_16370	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A16_16390	COG0456	acetyltransferase
A16_16440	COG0754	glutathionylspermidine amidase activity
A16_16470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A16_16530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A16_16560	COG1215	transferase activity, transferring glycosyl groups
A16_16570	COG0438	transferase activity, transferring glycosyl groups
A16_16600	COG0454	-acetyltransferase
A16_16640	COG0328	RNA-DNA hybrid ribonuclease activity
A16_16720	COG1280	lysine exporter protein (LysE YggA)
A16_16750	COG3162	membrane
A16_16760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A16_16770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A16_16790	COG0475	glutathione-regulated potassium exporter activity
A16_16800	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A16_16810	COG4978	Transcriptional regulator
A16_16810	COG0789	Transcriptional regulator
A16_16830	COG2323	membrane
A16_16850	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A16_16960	COG1923	regulation of RNA biosynthetic process
A16_16980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A16_16990	COG1360	Flagellar Motor Protein
A16_17000	COG2201	protein-glutamate methylesterase activity
A16_17030	COG1776	CheC inhibitor of MCP methylation
A16_17030	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A16_17060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A16_17100	COG1256	bacterial-type flagellum assembly
A16_17110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A16_17160	COG1815	bacterial-type flagellum-dependent cell motility
A16_17170	COG1558	bacterial-type flagellum-dependent cell motility
A16_17180	COG1677	Flagellar hook-basal body complex protein FliE
A16_17190	COG1766	The M ring may be actively involved in energy transduction
A16_17210	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A16_17230	COG1157	protein secretion by the type III secretion system
A16_17360	COG0463	Glycosyl transferase, family 2
A16_17430	COG0463	Glycosyl transferase, family 2
A16_17430	COG0457	Tetratricopeptide repeat
A16_17480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A16_17490	COG0741	lytic transglycosylase activity
A16_17530	COG1776	CheC inhibitor of MCP methylation
A16_17530	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A16_17550	COG1338	Plays a role in the flagellum-specific transport system
A16_17560	COG1987	bacterial-type flagellum assembly
A16_17580	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A16_17590	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A16_17620	COG4786	Flagellar basal body rod
A16_17630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A16_17680	COG1309	transcriptional regulator
A16_17710	COG2329	Antibiotic biosynthesis monooxygenase
A16_17770	COG3842	ATPase activity
A16_17780	COG0725	ABC transporter, periplasmic molybdate-binding protein
A16_17790	COG1177	transmembrane transport
A16_17800	COG1234	tRNA 3'-trailer cleavage
A16_17850	COG1686	Belongs to the peptidase S11 family
A16_17870	COG0406	alpha-ribazole phosphatase activity
A16_17940	COG0367	asparagine synthase
A16_18000	COG1802	Transcriptional regulator
A16_18010	COG0697	spore germination
A16_18020	COG0523	cobalamin synthesis protein
A16_18030	COG0701	Predicted permease
A16_18050	COG1216	Glycosyl transferase, family 2
A16_18050	COG0438	transferase activity, transferring glycosyl groups
A16_18070	COG1757	Na H antiporter
A16_18080	COG0114	fumarate hydratase activity
A16_18140	COG3340	Belongs to the peptidase S51 family
A16_18180	COG0785	Cytochrome C biogenesis protein
A16_18250	COG2733	membrane
A16_18320	COG1131	(ABC) transporter
A16_18370	COG0528	UMP kinase activity
A16_18390	COG1027	Aspartate ammonia-lyase
A16_18400	COG0281	malic enzyme
A16_18410	COG4191	Histidine kinase
A16_18420	COG0784	Response regulator, receiver
A16_18440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A16_18550	COG1051	belongs to the nudix hydrolase family
A16_18560	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16_18610	COG1966	Carbon starvation protein
A16_18650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16_18670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A16_18700	COG2223	nitrite transmembrane transporter activity
A16_18710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A16_18740	COG2244	polysaccharide biosynthetic process
A16_18750	COG0733	neurotransmitter:sodium symporter activity
A16_18770	COG5566	PFAM Mor transcription activator
A16_18780	COG2323	membrane
A16_18820	COG2084	Dehydrogenase
A16_18850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A16_18870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A16_18880	COG0028	Belongs to the TPP enzyme family
A16_18890	COG0440	acetolactate synthase activity
A16_18900	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A16_18920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A16_18960	COG2814	Major facilitator Superfamily
A16_18970	COG3384	dioxygenase
A16_18990	COG3279	Response regulator of the LytR AlgR family
A16_19000	COG0427	acetyl-CoA hydrolase
A16_19050	COG4166	transmembrane transport
A16_19110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_19160	COG1914	H( )-stimulated, divalent metal cation uptake system
A16_19190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A16_19270	COG2390	Transcriptional regulator
A16_19290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16_19300	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A16_19330	COG4224	UPF0291 protein
A16_19370	COG0006	proline dipeptidase activity
A16_19380	COG2132	Multicopper oxidase
A16_19450	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A16_19500	COG1276	copper resistance
A16_19500	COG2372	response to copper ion
A16_19510	COG4549	nuclear export factor GLE1
A16_19530	COG0697	spore germination
A16_19540	COG0583	DNA-binding transcription factor activity
A16_19550	COG1959	2 iron, 2 sulfur cluster binding
A16_19560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A16_19570	COG0778	Nitroreductase
A16_19600	COG0628	permease
A16_19610	COG0039	L-malate dehydrogenase activity
A16_19620	COG1231	oxidoreductase activity
A16_19630	COG0523	cobalamin synthesis protein
A16_19660	COG0318	PFAM AMP-dependent synthetase and ligase
A16_19670	COG2030	dehydratase
A16_19710	COG0411	ABC transporter
A16_19750	COG0583	DNA-binding transcription factor activity
A16_19790	COG1846	Transcriptional regulator
A16_19810	COG1271	oxidase subunit
A16_19820	COG1294	oxidase, subunit
A16_19830	COG4988	ABC transporter
A16_19840	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A16_19880	COG1686	Belongs to the peptidase S11 family
A16_19900	COG1388	LysM domain
A16_19900	COG0791	NLP P60 protein
A16_19920	COG1132	(ABC) transporter
A16_19930	COG1132	(ABC) transporter
A16_19940	COG0745	RESPONSE REGULATOR receiver
A16_19950	COG5002	protein histidine kinase activity
A16_19970	COG0300	oxidoreductase activity
A16_20000	COG0726	polysaccharide deacetylase
A16_20050	COG0460	homoserine dehydrogenase
A16_20100	COG1316	TRANSCRIPTIONal
A16_20120	COG0745	RESPONSE REGULATOR receiver
A16_20130	COG5002	protein histidine kinase activity
A16_20140	COG0726	polysaccharide deacetylase
A16_20160	COG1285	pathogenesis
A16_20170	COG1247	-acetyltransferase
A16_20190	COG4264	IucA IucC family
A16_20200	COG0318	PFAM AMP-dependent synthetase and ligase
A16_20230	COG1082	Xylose isomerase domain protein TIM barrel
A16_20280	COG1279	arginine transmembrane transporter activity
A16_20300	COG1752	Esterase of the alpha-beta hydrolase superfamily
A16_20400	COG2002	toxin-antitoxin pair type II binding
A16_20410	COG1404	Belongs to the peptidase S8 family
A16_20420	COG0640	Transcriptional regulator
A16_20430	COG0667	Aldo Keto reductase
A16_20440	COG2814	Major facilitator Superfamily
A16_20490	COG0840	transmembrane signaling receptor activity
A16_20520	COG3949	Membrane
A16_20530	COG0783	Belongs to the Dps family
A16_20560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A16_20580	COG1231	oxidoreductase activity
A16_20600	COG4989	oxidoreductase activity
A16_20610	COG0523	cobalamin synthesis protein
A16_20620	COG0456	acetyltransferase
A16_20710	COG0803	Belongs to the bacterial solute-binding protein 9 family
A16_20710	COG3443	Belongs to the bacterial solute-binding protein 9 family
A16_20730	COG0702	epimerase
A16_20750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A16_20770	COG4166	transmembrane transport
A16_20800	COG0406	alpha-ribazole phosphatase activity
A16_20820	COG5337	Spore coat protein CotH
A16_20830	COG1051	belongs to the nudix hydrolase family
A16_20840	COG0586	Pfam SNARE associated Golgi protein
A16_20850	COG2244	polysaccharide biosynthetic process
A16_20870	COG0701	Predicted permease
A16_20880	COG3689	TIGRFAM TIGR03943 family protein
A16_20890	COG1607	acyl-coa hydrolase
A16_20940	COG0702	epimerase
A16_20950	COG2839	Protein conserved in bacteria
A16_20960	COG1253	flavin adenine dinucleotide binding
A16_20990	COG1114	Component of the transport system for branched-chain amino acids
A16_21000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A16_21030	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16_21050	COG1876	peptidase activity
A16_21070	COG0154	amidase activity
A16_21080	COG2211	Major facilitator Superfamily
A16_21120	COG0561	phosphatase activity
A16_21140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A16_21180	COG1819	glycosyl
A16_21190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_21200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16_21270	COG0456	acetyltransferase
A16_21360	COG3874	Sporulation protein YtfJ
A16_21410	COG2226	methyltransferase
A16_21450	COG1082	Xylose isomerase domain protein TIM barrel
A16_21460	COG0346	lactoylglutathione lyase activity
A16_21480	COG0604	alcohol dehydrogenase
A16_21490	COG1595	DNA-templated transcription, initiation
A16_21540	COG0386	Belongs to the glutathione peroxidase family
A16_21550	COG1305	Transglutaminase-like
A16_21560	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
A16_21570	COG0714	Associated with various cellular activities
A16_21600	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A16_21610	COG1140	nitrate reductase beta subunit
A16_21620	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A16_21630	COG2181	nitrate reductase activity
A16_21670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A16_21680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A16_21690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A16_21700	COG0303	'Molybdopterin
A16_21710	COG0314	molybdopterin synthase activity
A16_21730	COG2223	nitrite transmembrane transporter activity
A16_21760	COG1648	precorrin-2 dehydrogenase activity
A16_21780	COG1587	Uroporphyrinogen-III synthase
A16_21780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A16_21790	COG2146	nitrite reductase [NAD(P)H] activity
A16_21800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A16_21810	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A16_21900	COG2359	stage V sporulation protein S
A16_21920	COG5632	N-Acetylmuramoyl-L-alanine amidase
A16_21960	COG1418	mRNA catabolic process
A16_21970	COG0488	(ABC) transporter
A16_22000	COG0629	single-stranded DNA binding
A16_22030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A16_22040	COG1413	lyase activity
A16_22070	COG2521	methyltransferase
A16_22070	COG2136	Putative SAM-dependent methyltransferase
A16_22080	COG0018	arginyl-trna synthetase
A16_22140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A16_22170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A16_22180	COG0017	Asparaginyl-tRNA synthetase
A16_22430	COG1929	Belongs to the glycerate kinase type-1 family
A16_22440	COG0471	metal ion transport
A16_22450	COG0745	RESPONSE REGULATOR receiver
A16_22460	COG3850	Histidine kinase
A16_22460	COG5002	protein histidine kinase activity
A16_22490	COG0733	neurotransmitter:sodium symporter activity
A16_22540	COG2610	gluconate transmembrane transporter activity
A16_22550	COG1454	alcohol dehydrogenase
A16_22560	COG1794	racemase activity, acting on amino acids and derivatives
A16_22580	COG0456	acetyltransferase
A16_22620	COG1131	(ABC) transporter
A16_22630	COG4473	ABC transporter
A16_22710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16_22740	COG0768	penicillin binding
A16_22750	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A16_22760	COG0204	Acyl-transferase
A16_22770	COG1272	protein, Hemolysin III
A16_22790	COG0805	protein transport
A16_22810	COG1307	EDD domain protein, DegV family
A16_22820	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A16_22840	COG1999	signal sequence binding
A16_22850	COG0071	Belongs to the small heat shock protein (HSP20) family
A16_22860	COG0367	asparagine synthase
A16_22900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_22910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A16_22990	COG0668	transmembrane transport
A16_23000	COG4585	Histidine kinase
A16_23000	COG2203	Gaf domain
A16_23010	COG2197	response regulator
A16_23030	COG1737	Transcriptional regulator
A16_23040	COG1064	alcohol dehydrogenase
A16_23110	COG1070	Carbohydrate kinase
A16_23180	COG1125	glycine betaine transport
A16_23180	COG0517	IMP dehydrogenase activity
A16_23190	COG1174	glycine betaine transport
A16_23260	COG1253	flavin adenine dinucleotide binding
A16_23270	COG1012	belongs to the aldehyde dehydrogenase family
A16_23280	COG5506	Protein of unknown function (DUF1694)
A16_23320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A16_23330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A16_23340	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A16_23350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A16_23360	COG0456	acetyltransferase
A16_23370	COG3829	transcription factor binding
A16_23380	COG1509	lysine 2,3-aminomutase activity
A16_23460	COG4326	sporulation control protein
A16_23470	COG0671	phosphoesterase, PA-phosphatase related
A16_23480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A16_23560	COG1715	Restriction endonuclease
A16_23560	COG1787	Restriction endonuclease
A16_23710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A16_23780	COG4499	WXG100 protein secretion system (Wss), protein YukC
A16_23780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16_23790	COG2814	Major facilitator Superfamily
A16_23810	COG4841	protein insertion into membrane
A16_23820	COG0372	Belongs to the citrate synthase family
A16_23830	COG2079	MmgE PrpD family protein
A16_23840	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A16_23860	COG1960	acyl-CoA dehydrogenase activity
A16_23870	COG2084	Dehydrogenase
A16_23880	COG1012	belongs to the aldehyde dehydrogenase family
A16_23890	COG1280	lysine exporter protein (LysE YggA)
A16_23900	COG1024	Enoyl-CoA hydratase
A16_23930	COG0420	3'-5' exonuclease activity
A16_23940	COG0419	ATPase involved in DNA repair
A16_24000	COG2223	nitrite transmembrane transporter activity
A16_24010	COG1028	Short-chain dehydrogenase reductase Sdr
A16_24020	COG1169	isochorismate synthase
A16_24030	COG1021	2,3-dihydroxybenzoate-AMP ligase
A16_24040	COG1535	isochorismatase
A16_24040	COG3433	isochorismatase activity
A16_24050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A16_24060	COG3251	PFAM MbtH domain protein
A16_24070	COG2814	Major facilitator Superfamily
A16_24100	COG0776	regulation of translation
A16_24120	COG2318	DinB family
A16_24140	COG1115	amino acid carrier protein
A16_24170	COG2329	Antibiotic biosynthesis monooxygenase
A16_24180	COG1187	pseudouridine synthase activity
A16_24200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A16_24240	COG0596	Alpha beta hydrolase
A16_24250	COG2814	Major facilitator Superfamily
A16_24300	COG2226	methyltransferase
A16_24380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_24450	COG1247	-acetyltransferase
A16_24530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_24550	COG1278	Cold shock
A16_24590	COG0010	Belongs to the arginase family
A16_24600	COG0561	phosphatase activity
A16_24670	COG0583	DNA-binding transcription factor activity
A16_24680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A16_24710	COG0583	DNA-binding transcription factor activity
A16_24720	COG2258	MOSC domain
A16_24750	COG1132	(ABC) transporter
A16_24760	COG1132	(ABC) transporter
A16_24790	COG1396	sequence-specific DNA binding
A16_24850	COG1595	DNA-templated transcription, initiation
A16_24910	COG1649	PFAM Uncharacterised BCR, COG1649
A16_24970	COG2971	BadF BadG BcrA BcrD
A16_24980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A16_24990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A16_25010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_25080	COG1309	transcriptional regulator
A16_25110	COG1136	(ABC) transporter
A16_25110	COG0577	efflux transmembrane transporter activity
A16_25120	COG3615	Tellurite resistance protein tehB
A16_25120	COG0500	methyltransferase
A16_25140	COG2226	methyltransferase
A16_25150	COG3961	Belongs to the TPP enzyme family
A16_25160	COG1846	Transcriptional regulator
A16_25250	COG2195	Cleaves the N-terminal amino acid of tripeptides
A16_25290	COG1595	DNA-templated transcription, initiation
A16_25310	COG0768	penicillin binding
A16_25350	COG2367	Beta-lactamase
A16_25360	COG0671	phosphoesterase, PA-phosphatase related
A16_25370	COG1609	Transcriptional regulator
A16_25380	COG2814	Major facilitator Superfamily
A16_25390	COG0673	inositol 2-dehydrogenase activity
A16_25410	COG1012	belongs to the aldehyde dehydrogenase family
A16_25470	COG3718	enzyme involved in inositol metabolism
A16_25510	COG0737	Belongs to the 5'-nucleotidase family
A16_25530	COG0737	Belongs to the 5'-nucleotidase family
A16_25550	COG0457	Tetratricopeptide repeat
A16_25560	COG1476	TRANSCRIPTIONal
A16_25580	COG1876	peptidase activity
A16_25630	COG1309	transcriptional regulator
A16_25670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_25700	COG1252	NADH dehydrogenase
A16_25710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16_25740	COG1131	(ABC) transporter
A16_25760	COG1309	transcriptional regulator
A16_25790	COG1960	acyl-CoA dehydrogenase activity
A16_25800	COG0439	Biotin carboxylase
A16_25810	COG0511	ligase activity, forming carbon-carbon bonds
A16_25820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A16_25830	COG1024	Enoyl-CoA hydratase
A16_25840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A16_25850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A16_25870	COG1247	-acetyltransferase
A16_25880	COG0572	uridine kinase
A16_25900	COG2318	DinB family
A16_25910	COG1686	Belongs to the peptidase S11 family
A16_25960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A16_26060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A16_26060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A16_26090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16_26110	COG2814	Major facilitator Superfamily
A16_26150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A16_26190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16_26220	COG1063	alcohol dehydrogenase
A16_26250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A16_26260	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A16_26280	COG3773	Cell wall hydrolase
A16_26300	COG0745	RESPONSE REGULATOR receiver
A16_26380	COG1136	(ABC) transporter
A16_26440	COG0460	homoserine dehydrogenase
A16_26450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16_26470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A16_26640	COG2124	cytochrome p450
A16_26710	COG0561	phosphatase activity
A16_26730	COG5002	protein histidine kinase activity
A16_26750	COG1819	glycosyl
A16_26760	COG1794	racemase activity, acting on amino acids and derivatives
A16_26780	COG1122	ATPase activity
A16_26810	COG2205	protein histidine kinase activity
A16_26840	COG0604	alcohol dehydrogenase
A16_26870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16_26940	COG0693	protein deglycase activity
A16_26990	COG2814	Major facilitator Superfamily
A16_27020	COG0584	glycerophosphoryl diester phosphodiesterase
A16_27070	COG0697	spore germination
A16_27150	COG2223	nitrite transmembrane transporter activity
A16_27180	COG2816	NAD+ diphosphatase activity
A16_27190	COG0592	DNA-directed DNA polymerase activity
A16_27200	COG1051	belongs to the nudix hydrolase family
A16_27270	COG3878	Protein conserved in bacteria
A16_27370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A16_27410	COG0322	excinuclease ABC activity
A16_27560	COG1011	Hydrolase
A16_27610	COG0076	glutamate decarboxylase activity
A16_27650	COG1523	belongs to the glycosyl hydrolase 13 family
A16_27660	COG3227	Zinc metalloprotease (Elastase)
A16_27700	COG0201	protein transport
A16_27720	COG0697	spore germination
A16_27730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16_27790	COG4129	membrane
A16_27800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_27830	COG2959	enzyme of heme biosynthesis
A16_27840	COG3409	Peptidoglycan-binding domain 1 protein
A16_27840	COG3773	Cell wall hydrolase
A16_27870	COG3483	tryptophan 2,3-dioxygenase activity
A16_27880	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A16_27890	COG3844	kynureninase activity
A16_27900	COG1309	transcriptional regulator
A16_27960	COG3284	Transcriptional regulator
A16_28000	COG1349	DNA-binding transcription factor activity
A16_28040	COG1959	2 iron, 2 sulfur cluster binding
A16_28080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A16_28090	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16_28100	COG0022	dehydrogenase e1 component
A16_28110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A16_28130	COG1028	Short-chain dehydrogenase reductase Sdr
A16_28140	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A16_28140	COG0456	acetyltransferase
A16_28190	COG4176	ABC-type proline glycine betaine transport system permease component
A16_28200	COG4175	Glycine betaine
A16_28200	COG0517	IMP dehydrogenase activity
A16_28220	COG0740	serine-type endopeptidase activity
A16_28250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A16_28260	COG2153	protein acetylation
A16_28270	COG3397	chitin binding
A16_28310	COG2205	protein histidine kinase activity
A16_28370	COG0658	competence protein
A16_28370	COG2333	competence protein COMEC
A16_28480	COG3973	AAA domain
A16_28510	COG2105	PFAM AIG2 family protein
A16_28520	COG0514	ATP-dependent DNA helicase (RecQ)
A16_28550	COG4637	Psort location Cytoplasmic, score
A16_28600	COG3397	chitin binding
A16_28620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A16_28630	COG1115	amino acid carrier protein
A16_28640	COG1012	belongs to the aldehyde dehydrogenase family
A16_28650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A16_28670	COG3938	Belongs to the proline racemase family
A16_28680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A16_28760	COG0586	Pfam SNARE associated Golgi protein
A16_28790	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A16_28800	COG0519	Catalyzes the synthesis of GMP from XMP
A16_28810	COG4166	transmembrane transport
A16_28830	COG4948	Mandelate Racemase Muconate Lactonizing
A16_28910	COG2936	dipeptidyl-peptidase activity
A16_28920	COG5002	protein histidine kinase activity
A16_28930	COG0745	RESPONSE REGULATOR receiver
A16_29030	COG1307	EDD domain protein, DegV family
A16_29070	COG2814	Major facilitator Superfamily
A16_29090	COG1664	Polymer-forming cytoskeletal
A16_29100	COG0789	Transcriptional regulator
A16_29110	COG4533	DNA binding
A16_29120	COG0477	Major facilitator Superfamily
A16_29120	COG2814	Major facilitator Superfamily
A16_29170	COG2261	transglycosylase associated protein
A16_29200	COG2226	methyltransferase
A16_29280	COG0436	Aminotransferase
A16_29290	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A16_29300	COG5146	pantothenate kinase activity
A16_29360	COG1131	(ABC) transporter
A16_29430	COG0628	permease
A16_29450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A16_29460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A16_29470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A16_29480	COG1116	anion transmembrane transporter activity
A16_29560	COG2746	aminoglycoside 3-N-acetyltransferase activity
A16_29610	COG0697	spore germination
A16_29620	COG2318	DinB family
A16_29660	COG4912	Dna alkylation repair
A16_29690	COG0726	polysaccharide deacetylase
A16_29710	COG0861	Integral membrane protein TerC family
A16_29720	COG1368	sulfuric ester hydrolase activity
A16_29740	COG0488	(ABC) transporter
A16_29760	COG1033	growth of symbiont in host cell
A16_29760	COG2409	Drug exporters of the RND superfamily
A16_29770	COG1033	growth of symbiont in host cell
A16_29770	COG2409	Drug exporters of the RND superfamily
A16_29780	COG2409	Drug exporters of the RND superfamily
A16_29780	COG1033	growth of symbiont in host cell
A16_29790	COG1309	transcriptional regulator
A16_29820	COG0287	Prephenate dehydrogenase
A16_29830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A16_29840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A16_29850	COG1605	Chorismate mutase
A16_29850	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A16_29930	COG3584	3D domain protein
A16_29930	COG1388	LysM domain
A16_29950	COG1595	DNA-templated transcription, initiation
A16_30000	COG1879	ABC-type sugar transport system periplasmic component
A16_30030	COG1172	Belongs to the binding-protein-dependent transport system permease family
A16_30050	COG2390	Transcriptional regulator
A16_30140	COG2329	Antibiotic biosynthesis monooxygenase
A16_30180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16_30200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A16_30210	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16_30220	COG4187	Peptidase family M20/M25/M40
A16_30230	COG1414	Transcriptional regulator
A16_30240	COG0833	amino acid
A16_30250	COG1690	Belongs to the RtcB family
A16_30270	COG1785	Belongs to the alkaline phosphatase family
A16_30290	COG3655	Transcriptional regulator
A16_30320	COG4377	Putative membrane peptidase family (DUF2324)
A16_30370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_30380	COG0346	lactoylglutathione lyase activity
A16_30420	COG0714	Associated with various cellular activities
A16_30520	COG0463	Glycosyl transferase, family 2
A16_30550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A16_30560	COG0753	catalase activity
A16_30580	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A16_30670	COG0778	Nitroreductase
A16_30680	COG1846	Transcriptional regulator
A16_30770	COG1725	Transcriptional regulator
A16_30800	COG1136	(ABC) transporter
A16_30800	COG0577	efflux transmembrane transporter activity
A16_30850	COG2207	Transcriptional regulator
A16_30860	COG0456	acetyltransferase
A16_30950	COG0642	Histidine kinase
A16_30960	COG0745	RESPONSE REGULATOR receiver
A16_30970	COG0596	Alpha beta hydrolase
A16_31030	COG0730	response to heat
A16_31050	COG0833	amino acid
A16_31070	COG4335	DNA alkylation repair
A16_31180	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A16_31260	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A16_31270	COG1414	Transcriptional regulator
A16_31300	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16_31310	COG0640	Transcriptional regulator
A16_31330	COG1960	acyl-CoA dehydrogenase activity
A16_31400	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A16_31430	COG3848	Pyruvate phosphate dikinase
A16_31430	COG0574	Belongs to the PEP-utilizing enzyme family
A16_31450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_31480	COG5577	PFAM Coat F domain
A16_31490	COG3403	YqcI/YcgG family
A16_31500	COG1280	lysine exporter protein (LysE YggA)
A16_31580	COG1063	alcohol dehydrogenase
A16_31610	COG1027	Aspartate ammonia-lyase
A16_31620	COG0252	asparaginase activity
A16_31630	COG1396	sequence-specific DNA binding
A16_31650	COG0322	excinuclease ABC activity
A16_31660	COG0531	amino acid
A16_31670	COG1114	Component of the transport system for branched-chain amino acids
A16_31710	COG0281	malic enzyme
A16_31760	COG0531	amino acid
A16_31770	COG0697	spore germination
A16_31820	COG2066	Belongs to the glutaminase family
A16_31900	COG0737	Belongs to the 5'-nucleotidase family
A16_31910	COG0753	catalase activity
A16_31920	COG2267	carboxylic ester hydrolase activity
A16_31930	COG1335	isochorismatase
A16_31980	COG0583	DNA-binding transcription factor activity
A16_32080	COG0415	Belongs to the DNA photolyase family
A16_32090	COG0288	reversible hydration of carbon dioxide
A16_32110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A16_32120	COG5609	conserved protein (DUF2294)
A16_32140	COG1575	Belongs to the MenA family. Type 1 subfamily
A16_32150	COG2267	carboxylic ester hydrolase activity
A16_32160	COG0803	Belongs to the bacterial solute-binding protein 9 family
A16_32170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A16_32180	COG1121	(ABC) transporter
A16_32240	COG0798	PFAM Bile acid sodium symporter
A16_32250	COG0346	lactoylglutathione lyase activity
A16_32260	COG0640	Transcriptional regulator
A16_32290	COG0443	Heat shock 70 kDa protein
A16_32320	COG1522	sequence-specific DNA binding
A16_32350	COG0346	lactoylglutathione lyase activity
A16_32480	COG2814	Major facilitator Superfamily
A16_32530	COG0745	RESPONSE REGULATOR receiver
A16_32540	COG3850	Histidine kinase
A16_32540	COG5002	protein histidine kinase activity
A16_32600	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A16_32660	COG1476	TRANSCRIPTIONal
A16_32690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_32700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A16_32720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16_32730	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A16_32760	COG1136	(ABC) transporter
A16_32780	COG0577	efflux transmembrane transporter activity
A16_32810	COG5002	protein histidine kinase activity
A16_32810	COG3850	Histidine kinase
A16_32830	COG2364	Membrane
A16_32840	COG1846	Transcriptional regulator
A16_32870	COG2808	Putative FMN-binding domain
A16_32880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_32890	COG2271	Major facilitator Superfamily
A16_32900	COG1556	Lactate utilization protein
A16_32910	COG1139	Iron-sulfur cluster binding protein
A16_32930	COG0583	DNA-binding transcription factor activity
A16_32950	COG1619	proteins homologs of microcin C7 resistance protein MccF
A16_33010	COG0561	phosphatase activity
A16_33040	COG1609	Transcriptional regulator
A16_33050	COG0457	Tetratricopeptide repeat
A16_33090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A16_33160	COG0534	Mate efflux family protein
A16_33200	COG2814	Major facilitator Superfamily
A16_33210	COG1309	transcriptional regulator
A16_33230	COG0814	amino acid
A16_33240	COG1760	l-serine dehydratase
A16_33250	COG1760	l-serine dehydratase
A16_33270	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A16_33280	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A16_33300	COG1335	isochorismatase
A16_33310	COG1522	sequence-specific DNA binding
A16_33320	COG0531	amino acid
A16_33350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A16_33400	COG1595	DNA-templated transcription, initiation
A16_33430	COG0662	Cupin 2, conserved barrel domain protein
A16_33440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_33440	COG2207	Transcriptional regulator
A16_33560	COG0477	Major facilitator Superfamily
A16_33580	COG1846	Transcriptional regulator
A16_33590	COG2814	Major facilitator Superfamily
A16_33620	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A16_33630	COG1131	(ABC) transporter
A16_33680	COG2076	Multidrug Resistance protein
A16_33690	COG1309	transcriptional regulator
A16_33710	COG2031	fatty acid transporter
A16_33730	COG2249	NAD(P)H dehydrogenase (quinone) activity
A16_33790	COG1122	ATPase activity
A16_33800	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A16_33830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A16_33840	COG1288	antiporter activity
A16_33850	COG2356	endonuclease I
A16_33880	COG3620	sequence-specific DNA binding
A16_33890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A16_33900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A16_33910	COG0124	histidyl-tRNA synthetase
A16_33940	COG1733	regulation of RNA biosynthetic process
A16_33950	COG0778	Nitroreductase
A16_33990	COG1028	Short-chain dehydrogenase reductase Sdr
A16_34010	COG1131	(ABC) transporter
A16_34060	COG1011	Hydrolase
A16_34130	COG0346	lactoylglutathione lyase activity
A16_34140	COG1940	carbohydrate kinase activity
A16_34150	COG0738	Major facilitator superfamily
A16_34160	COG0110	maltose O-acetyltransferase activity
A16_34190	COG1136	(ABC) transporter
A16_34210	COG0180	Tryptophanyl-tRNA synthetase
A16_34220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A16_34230	COG0628	permease
A16_34300	COG0477	Major facilitator Superfamily
A16_34360	COG1253	flavin adenine dinucleotide binding
A16_34370	COG0789	Transcriptional regulator
A16_34380	COG0697	spore germination
A16_34390	COG1357	PFAM Pentapeptide repeats (8 copies)
A16_34400	COG3813	Protein conserved in bacteria
A16_34410	COG2706	6-phosphogluconolactonase activity
A16_34420	COG1070	Carbohydrate kinase
A16_34440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A16_34450	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A16_34470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A16_34480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A16_34490	COG0604	alcohol dehydrogenase
A16_34500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A16_34530	COG1028	Short-chain dehydrogenase reductase Sdr
A16_34580	COG0656	L-ascorbic acid biosynthetic process
A16_34590	COG2814	Major facilitator Superfamily
A16_34620	COG0346	lactoylglutathione lyase activity
A16_34630	COG0814	amino acid
A16_34680	COG1393	Belongs to the ArsC family
A16_34690	COG1733	regulation of RNA biosynthetic process
A16_34700	COG2188	Transcriptional regulator
A16_34730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A16_34740	COG1733	regulation of RNA biosynthetic process
A16_34750	COG1733	regulation of RNA biosynthetic process
A16_34780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_34820	COG0384	phenazine biosynthesis protein PhzF
A16_34840	COG1028	Short-chain dehydrogenase reductase Sdr
A16_34860	COG0318	PFAM AMP-dependent synthetase and ligase
A16_34890	COG1733	regulation of RNA biosynthetic process
A16_34970	COG1191	sigma factor activity
A16_35010	COG1309	transcriptional regulator
A16_35100	COG1151	hydroxylamine reductase activity
A16_35120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_35130	COG3409	Peptidoglycan-binding domain 1 protein
A16_35130	COG3757	hydrolase, family 25
A16_35200	COG2072	flavoprotein involved in K transport
A16_35290	COG1113	amino acid transport
A16_35300	COG2814	Major facilitator Superfamily
A16_35370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A16_35380	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A16_35430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_35450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_35460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_35470	COG3739	integral membrane protein
A16_35480	COG0384	phenazine biosynthesis protein PhzF
A16_35540	COG0583	DNA-binding transcription factor activity
A16_35580	COG1193	negative regulation of DNA recombination
A16_35620	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A16_35630	COG1164	Oligoendopeptidase f
A16_35640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16_35700	COG0584	glycerophosphoryl diester phosphodiesterase
A16_35740	COG0640	Transcriptional regulator
A16_35750	COG0604	alcohol dehydrogenase
A16_35800	COG2808	Putative FMN-binding domain
A16_35810	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A16_35820	COG0385	Bile acid
A16_35830	COG0277	FAD linked oxidase domain protein
A16_35890	COG1216	Glycosyl transferase, family 2
A16_35900	COG1024	Enoyl-CoA hydratase
A16_35920	COG1285	pathogenesis
A16_35940	COG2514	catechol 2,3-dioxygenase activity
A16_35950	COG2720	vancomycin resistance protein
A16_36010	COG1278	Cold shock
A16_36030	COG0716	FMN binding
A16_36090	COG1028	Short-chain dehydrogenase reductase Sdr
A16_36110	COG0165	Argininosuccinate lyase
A16_36140	COG4145	pantothenate transmembrane transporter activity
A16_36150	COG3924	membrane
A16_36160	COG1012	belongs to the aldehyde dehydrogenase family
A16_36170	COG1028	Short-chain dehydrogenase reductase Sdr
A16_36190	COG1657	PFAM Prenyltransferase squalene oxidase
A16_36200	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
A16_36210	COG2962	Rard protein
A16_36220	COG3326	Membrane
A16_36250	COG0489	protein tyrosine kinase activity
A16_36270	COG0314	molybdopterin synthase activity
A16_36280	COG0303	'Molybdopterin
A16_36290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A16_36300	COG2116	formate transmembrane transporter activity
A16_36320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A16_36330	COG5609	conserved protein (DUF2294)
A16_36340	COG2427	Protein of unknown function (DUF1641)
A16_36360	COG3383	formate dehydrogenase (NAD+) activity
A16_36380	COG0697	spore germination
A16_36470	COG2226	methyltransferase
A16_36480	COG4166	transmembrane transport
A16_36490	COG4166	transmembrane transport
A16_36510	COG4166	transmembrane transport
A16_36520	COG1301	dicarboxylic acid transport
A16_36530	COG1316	TRANSCRIPTIONal
A16_36550	COG1595	DNA-templated transcription, initiation
A16_36600	COG1131	(ABC) transporter
A16_36620	COG0673	inositol 2-dehydrogenase activity
A16_36630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A16_36640	COG0187	DNA topoisomerase II activity
A16_36650	COG1832	CoA-binding protein
A16_36660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A16_36670	COG0745	RESPONSE REGULATOR receiver
A16_36710	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A16_36720	COG4841	protein insertion into membrane
A16_36730	COG0824	Thioesterase
A16_36800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16_36820	COG2274	protein secretion by the type I secretion system
A16_36830	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A16_36860	COG0726	polysaccharide deacetylase
A16_36890	COG2211	Major facilitator Superfamily
A16_36910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A16_36940	COG0183	Belongs to the thiolase family
A16_36950	COG0318	PFAM AMP-dependent synthetase and ligase
A16_36960	COG1268	BioY protein
A16_36970	COG0318	PFAM AMP-dependent synthetase and ligase
A16_37060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_37080	COG5002	protein histidine kinase activity
A16_37090	COG0400	carboxylic ester hydrolase activity
A16_37100	COG0346	lactoylglutathione lyase activity
A16_37110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A16_37120	COG0069	glutamate synthase activity
A16_37130	COG1902	pentaerythritol trinitrate reductase activity
A16_37140	COG1329	Transcriptional regulator
A16_37150	COG0010	Belongs to the arginase family
A16_37200	COG2226	methyltransferase
A16_37310	COG4846	Membrane protein involved in cytochrome C biogenesis
A16_37320	COG0785	Cytochrome C biogenesis protein
A16_37340	COG0583	DNA-binding transcription factor activity
A16_37350	COG1380	Effector of murein hydrolase LrgA
A16_37360	COG1346	cytolysis
A16_37400	COG0730	response to heat
A16_37420	COG5632	N-Acetylmuramoyl-L-alanine amidase
A16_37420	COG3409	Peptidoglycan-binding domain 1 protein
A16_37450	COG1132	(ABC) transporter
A16_37460	COG1132	(ABC) transporter
A16_37520	COG3639	organic phosphonate transmembrane transporter activity
A16_37530	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A16_37560	COG0737	Belongs to the 5'-nucleotidase family
A16_37580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A16_37620	COG1695	Transcriptional regulator
A16_37710	COG5632	N-Acetylmuramoyl-L-alanine amidase
A16_37710	COG3409	Peptidoglycan-binding domain 1 protein
A16_37710	COG1388	LysM domain
A16_37720	COG4824	toxin secretion phage lysis holin
A16_38040	COG1595	DNA-templated transcription, initiation
A16_38160	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A16_38370	COG0174	glutamine synthetase
A16_38380	COG0789	Transcriptional regulator
A16_38390	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A16_38420	COG2860	membrane
A16_38430	COG0464	growth
A16_38490	COG1388	LysM domain
A16_38490	COG3584	3D domain protein
A16_38500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A16_38500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A16_38500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A16_38510	COG1105	Belongs to the carbohydrate kinase PfkB family
A16_38520	COG1349	DNA-binding transcription factor activity
A16_38550	COG2322	membrane
A16_38580	COG1113	amino acid transport
A16_38610	COG1408	metallophosphoesterase
A16_38620	COG2116	formate transmembrane transporter activity
A16_38640	COG2217	Heavy metal translocating P-type atpase
A16_38650	COG2608	mercury ion transmembrane transporter activity
A16_38660	COG1937	Protein conserved in bacteria
A16_38680	COG2819	hydrolase of the alpha beta superfamily
A16_38690	COG1120	ATPase activity
A16_38700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_38710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_38720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_38740	COG0708	Exodeoxyribonuclease III
A16_38750	COG2169	Transcriptional regulator
A16_38760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A16_38770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A16_38790	COG2364	Membrane
A16_38830	COG2267	carboxylic ester hydrolase activity
A16_38840	COG0346	lactoylglutathione lyase activity
A16_38850	COG5001	Diguanylate cyclase
A16_38850	COG3300	MHYT domain
A16_38900	COG1346	cytolysis
A16_38910	COG1380	Effector of murein hydrolase LrgA
A16_38920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16_38930	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16_38930	COG0596	Alpha beta hydrolase
A16_38940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A16_38980	COG1404	Belongs to the peptidase S8 family
A16_38990	COG3773	Cell wall hydrolase
A16_39000	COG0562	UDP-galactopyranose mutase
A16_39010	COG1368	sulfuric ester hydrolase activity
A16_39020	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A16_39040	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A16_39150	COG4550	Control of competence regulator ComK, YlbF/YmcA
A16_39160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A16_39170	COG1013	pyruvate-flavodoxin oxidoreductase activity
A16_39180	COG0674	pyruvate-flavodoxin oxidoreductase activity
A16_39180	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A16_39200	COG2359	stage V sporulation protein S
A16_39210	COG1692	metallophosphoesterase
A16_39260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A16_39270	COG1426	Protein conserved in bacteria
A16_39300	COG0300	oxidoreductase activity
A16_39310	COG0612	Peptidase, M16
A16_39320	COG0612	Peptidase, M16
A16_39380	COG2188	Transcriptional regulator
A16_39390	COG1674	ftsk spoiiie
A16_39410	COG0740	serine-type endopeptidase activity
A16_39420	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A16_39440	COG0527	aspartate kinase activity
A16_39450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A16_39460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A16_39470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A16_39480	COG1873	PFAM PRC-barrel domain
A16_39490	COG0612	Peptidase, M16
A16_39500	COG0726	polysaccharide deacetylase
A16_39530	COG0196	riboflavin kinase activity
A16_39540	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A16_39560	COG1550	Protein conserved in bacteria
A16_39580	COG1358	cellular component organization or biogenesis
A16_39590	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A16_39600	COG0195	Participates in both transcription termination and antitermination
A16_39640	COG0750	zinc metalloprotease
A16_39650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A16_39660	COG4589	Belongs to the CDS family
A16_39670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A16_39690	COG0528	UMP kinase activity
A16_39750	COG4974	Belongs to the 'phage' integrase family
A16_39770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A16_39790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A16_39870	COG1837	Belongs to the UPF0109 family
A16_39890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A16_39910	COG0552	protein localization to endoplasmic reticulum
A16_39920	COG1196	nuclear chromosome segregation
A16_39960	COG1028	Short-chain dehydrogenase reductase Sdr
A16_39970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A16_40000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A16_40010	COG1461	Dihydroxyacetone kinase
A16_40020	COG1302	Protein conserved in bacteria
A16_40040	COG1564	THIamine pyrophosphokinase
A16_40050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A16_40060	COG1162	GTPase activity
A16_40070	COG2815	serine threonine protein kinase
A16_40070	COG0515	serine threonine protein kinase
A16_40080	COG0631	protein serine/threonine phosphatase activity
A16_40100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A16_40100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A16_40120	COG0242	peptide deformylase activity
A16_40130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A16_40140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A16_40160	COG0194	GDP metabolic process
A16_40180	COG1561	YicC-like family, N-terminal region
A16_40190	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A16_40210	COG0006	proline dipeptidase activity
A16_40240	COG3069	C4-dicarboxylate transmembrane transporter activity
A16_40320	COG0505	Belongs to the CarA family
A16_40370	COG0564	pseudouridine synthase activity
A16_40400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A16_40410	COG3599	regulation of cell shape
A16_40420	COG2302	S4 RNA-binding domain
A16_40430	COG0762	integral membrane protein
A16_40450	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A16_40470	COG1873	PFAM PRC-barrel domain
A16_40480	COG1191	sigma factor activity
A16_40490	COG1191	sigma factor activity
A16_40510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A16_40520	COG0849	cell division
A16_40530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A16_40540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A16_40550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A16_40560	COG0772	Belongs to the SEDS family
A16_40590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A16_40600	COG0768	penicillin binding
A16_40620	COG4839	cell division protein FtsL
A16_40650	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A16_40690	COG1399	metal-binding, possibly nucleic acid-binding protein
A16_40800	COG4824	toxin secretion phage lysis holin
A16_41000	COG1802	Transcriptional regulator
A16_41000	COG4626	Terminase
A16_41050	COG0582	viral genome integration into host DNA
A16_41200	COG1191	sigma factor activity
A16_41240	COG1484	DNA-dependent DNA replication
A16_41300	COG1396	sequence-specific DNA binding
A16_41370	COG0582	viral genome integration into host DNA
A16_41390	COG3480	Lon protease (S16) C-terminal proteolytic domain
A16_41400	COG1752	Esterase of the alpha-beta hydrolase superfamily
A16_41410	COG3314	Sporulation integral membrane protein YlbJ
A16_41430	COG0742	ribosomal rna small subunit methyltransferase
A16_41470	COG3679	Belongs to the UPF0342 family
A16_41480	COG0406	alpha-ribazole phosphatase activity
A16_41510	COG2340	Cysteine-rich secretory protein family
A16_41540	COG3336	cytochrome c oxidase
A16_41610	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A16_41620	COG0772	Belongs to the SEDS family
A16_41630	COG4838	Belongs to the UPF0358 family
A16_41640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A16_41650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A16_41670	COG4896	Protein conserved in bacteria
A16_41720	COG0483	inositol monophosphate 1-phosphatase activity
A16_41760	COG1982	Orn Lys Arg decarboxylase major
A16_41840	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16_41850	COG0022	dehydrogenase e1 component
A16_41860	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A16_41900	COG0561	phosphatase activity
A16_41920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A16_41930	COG0569	domain protein
A16_41970	COG0583	DNA-binding transcription factor activity
A16_41980	COG0517	IMP dehydrogenase activity
A16_42000	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
A16_42020	COG4703	Protein of unknown function (DUF1797)
A16_42060	COG2200	EAL domain
A16_42070	COG1028	Short-chain dehydrogenase reductase Sdr
A16_42080	COG1408	metallophosphoesterase
A16_42100	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A16_42180	COG2814	Major facilitator Superfamily
A16_42220	COG3209	COG3209 Rhs family protein
A16_42240	COG2205	protein histidine kinase activity
A16_42260	COG0436	Aminotransferase
A16_42270	COG1609	Transcriptional regulator
A16_42290	COG3833	ABC-type maltose transport systems, permease component
A16_42300	COG1175	transmembrane transport
A16_42310	COG2182	Extracellular solute-binding protein
A16_42330	COG0366	Alpha amylase catalytic
A16_42340	COG3842	ATPase activity
A16_42410	COG0183	Belongs to the thiolase family
A16_42490	COG1695	Transcriptional regulator
A16_42500	COG1028	Short-chain dehydrogenase reductase Sdr
A16_42540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A16_42550	COG0436	Aminotransferase
A16_42590	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A16_42640	COG3706	GGDEF domain
A16_42650	COG0778	Nitroreductase
A16_42700	COG2190	(PTS) system
A16_42700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16_42700	COG1263	PTS System
A16_42710	COG3711	transcriptional antiterminator
A16_42750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A16_42790	COG1547	Domain of unknown function (DUF309)
A16_42800	COG0456	acetyltransferase
A16_42820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A16_42830	COG4086	secreted protein
A16_42840	COG0561	phosphatase activity
A16_42850	COG0697	spore germination
A16_42880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16_42930	COG0733	neurotransmitter:sodium symporter activity
A16_42970	COG1686	Belongs to the peptidase S11 family
A16_42980	COG1725	Transcriptional regulator
A16_42990	COG1131	(ABC) transporter
A16_43020	COG1846	Transcriptional regulator
A16_43050	COG0598	Magnesium transport protein CorA
A16_43100	COG4974	Belongs to the 'phage' integrase family
A16_43120	COG0735	belongs to the Fur family
A16_43130	COG1300	Membrane
A16_43170	COG0667	Aldo Keto reductase
A16_43180	COG0656	L-ascorbic acid biosynthetic process
A16_43190	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A16_43190	COG0456	acetyltransferase
A16_43210	COG1525	nuclease
A16_43210	COG4085	toxin activity
A16_43210	COG0737	Belongs to the 5'-nucleotidase family
A16_43230	COG0596	Alpha beta hydrolase
A16_43240	COG2056	Na+-H+ antiporter family
A16_43250	COG1609	Transcriptional regulator
A16_43260	COG0456	acetyltransferase
A16_43270	COG1073	alpha beta
A16_43300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A16_43300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A16_43310	COG0307	riboflavin synthase, alpha
A16_43350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A16_43360	COG4106	trans-aconitate 2-methyltransferase activity
A16_43370	COG2226	methyltransferase
A16_43370	COG1073	alpha beta
A16_43380	COG0156	8-amino-7-oxononanoate synthase activity
A16_43400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A16_43450	COG0737	Belongs to the 5'-nucleotidase family
A16_43470	COG1522	sequence-specific DNA binding
A16_43510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A16_43530	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A16_43560	COG0300	oxidoreductase activity
A16_43570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_43590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16_43600	COG1760	l-serine dehydratase
A16_43610	COG1760	l-serine dehydratase
A16_43650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A16_43660	COG2195	Cleaves the N-terminal amino acid of tripeptides
A16_43670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_43690	COG1376	ErfK ybiS ycfS ynhG family protein
A16_43700	COG4129	membrane
A16_43710	COG1126	abc transporter atp-binding protein
A16_43720	COG0765	amino acid transport
A16_43730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16_43770	COG2816	NAD+ diphosphatase activity
A16_43780	COG0772	Belongs to the SEDS family
A16_43790	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16_43800	COG0022	dehydrogenase e1 component
A16_43810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A16_43820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A16_43840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A16_43850	COG0280	phosphate acetyltransferase
A16_43860	COG3829	transcription factor binding
A16_43860	COG3290	protein histidine kinase activity
A16_43880	COG0584	glycerophosphoryl diester phosphodiesterase
A16_43890	COG3093	addiction module antidote protein HigA
A16_43910	COG0745	RESPONSE REGULATOR receiver
A16_43920	COG0750	zinc metalloprotease
A16_43930	COG0497	DNA recombination
A16_43950	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A16_43970	COG0142	geranyltranstransferase activity
A16_44020	COG1302	Protein conserved in bacteria
A16_44030	COG0439	Biotin carboxylase
A16_44040	COG0511	ligase activity, forming carbon-carbon bonds
A16_44120	COG3854	ATPases associated with a variety of cellular activities
A16_44170	COG0006	proline dipeptidase activity
A16_44200	COG3872	metal-dependent enzyme
A16_44220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A16_44270	COG0095	Lipoate-protein ligase
A16_44280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16_44290	COG1609	Transcriptional regulator
A16_44310	COG2076	Multidrug Resistance protein
A16_44320	COG2076	Multidrug Resistance protein
A16_44400	COG1131	(ABC) transporter
A16_44410	COG1725	Transcriptional regulator
A16_44470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A16_44590	COG4970	Tfp pilus assembly protein FimT
A16_44610	COG1459	type II secretion system
A16_44620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A16_44720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A16_44730	COG0646	methionine synthase
A16_44730	COG1410	methionine synthase
A16_44740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A16_44740	COG0646	methionine synthase
A16_44750	COG0626	cystathionine gamma-synthase activity
A16_44760	COG0626	cystathionine gamma-synthase activity
A16_44800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_44820	COG1940	carbohydrate kinase activity
A16_44830	COG4483	Protein conserved in bacteria
A16_44840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A16_44860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A16_44870	COG0704	Plays a role in the regulation of phosphate uptake
A16_44880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A16_44890	COG0581	inorganic phosphate transmembrane transporter activity
A16_44900	COG0573	inorganic phosphate transmembrane transporter activity
A16_44910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A16_44930	COG0477	Major facilitator Superfamily
A16_44940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A16_44990	COG0735	belongs to the Fur family
A16_45000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A16_45010	COG1121	(ABC) transporter
A16_45020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_45090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A16_45100	COG2384	SAM-dependent methyltransferase
A16_45110	COG2010	Cytochrome c
A16_45120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A16_45130	COG0358	DNA primase activity
A16_45170	COG0517	IMP dehydrogenase activity
A16_45200	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A16_45210	COG0295	cytidine deaminase activity
A16_45220	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A16_45240	COG1480	7TM receptor with intracellular HD hydrolase
A16_45250	COG1702	phosphate starvation-inducible protein PhoH
A16_45290	COG1610	YqeY-like protein
A16_45310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A16_45320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A16_45360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A16_45380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A16_45390	COG1733	regulation of RNA biosynthetic process
A16_45440	COG1466	dna polymerase III delta subunit
A16_45460	COG2333	competence protein COMEC
A16_45460	COG0658	competence protein
A16_45480	COG2131	deaminase
A16_45490	COG1596	polysaccharide export
A16_45490	COG1555	photosystem II stabilization
A16_45500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16_45510	COG2226	methyltransferase
A16_45520	COG0799	negative regulation of ribosome biogenesis
A16_45530	COG1713	HD superfamily hydrolase involved in NAD metabolism
A16_45570	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A16_45580	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A16_45610	COG1191	sigma factor activity
A16_45640	COG1595	DNA-templated transcription, initiation
A16_45660	COG0778	Nitroreductase
A16_45680	COG2357	RelA SpoT domain protein
A16_45700	COG1785	Belongs to the alkaline phosphatase family
A16_45720	COG2267	carboxylic ester hydrolase activity
A16_45830	COG3186	Phenylalanine-4-hydroxylase
A16_45850	COG2514	catechol 2,3-dioxygenase activity
A16_45860	COG2514	catechol 2,3-dioxygenase activity
A16_45870	COG2259	Doxx family
A16_45950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_45970	COG1012	belongs to the aldehyde dehydrogenase family
A16_45970	COG1454	alcohol dehydrogenase
A16_45980	COG0626	cystathionine gamma-synthase activity
A16_45990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A16_46040	COG0768	penicillin binding
A16_46100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A16_46140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A16_46160	COG0628	permease
A16_46200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A16_46220	COG0482	sulfurtransferase activity
A16_46230	COG1104	cysteine desulfurase activity
A16_46240	COG1959	2 iron, 2 sulfur cluster binding
A16_46250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A16_46270	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A16_46290	COG0124	histidyl-tRNA synthetase
A16_46320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A16_46340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A16_46340	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A16_46350	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A16_46360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A16_46360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A16_46380	COG2244	polysaccharide biosynthetic process
A16_46390	COG2323	membrane
A16_46410	COG1862	Preprotein translocase
A16_46470	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A16_46490	COG0697	spore germination
A16_46500	COG0697	spore germination
A16_46510	COG0640	Transcriptional regulator
A16_46560	COG0157	Belongs to the NadC ModD family
A16_46570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A16_46580	COG1104	cysteine desulfurase activity
A16_46590	COG1827	regulation of RNA biosynthetic process
A16_46600	COG2258	MOSC domain
A16_46610	COG0077	Prephenate dehydratase
A16_46620	COG0577	efflux transmembrane transporter activity
A16_46630	COG0577	efflux transmembrane transporter activity
A16_46640	COG1136	(ABC) transporter
A16_46650	COG5002	protein histidine kinase activity
A16_46670	COG0745	RESPONSE REGULATOR receiver
A16_46680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A16_46690	COG3290	protein histidine kinase activity
A16_46710	COG2868	ribosomal protein
A16_46730	COG1530	ribonuclease E activity
A16_46740	COG1994	Peptidase M50
A16_46750	COG0739	heme binding
A16_46760	COG2894	cell division
A16_46790	COG1792	Involved in formation and maintenance of cell shape
A16_46800	COG1077	Cell shape determining protein MreB Mrl
A16_46840	COG0285	dihydrofolate synthase activity
A16_46850	COG0525	valine-tRNA ligase activity
A16_46870	COG1388	LysM domain
A16_46890	COG0113	porphobilinogen synthase activity
A16_46900	COG1587	Uroporphyrinogen-III synthase
A16_46920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A16_46940	COG1846	Transcriptional regulator
A16_46950	COG1764	response to oxidative stress
A16_46980	COG1067	ATP-dependent peptidase activity
A16_46980	COG0470	DNA polymerase III
A16_47070	COG0622	Phosphoesterase
A16_47080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A16_47100	COG5401	PFAM Sporulation and spore germination
A16_47150	COG1309	transcriptional regulator
A16_47180	COG2197	response regulator
A16_47190	COG2233	PERMEase
A16_47210	COG0402	S-adenosylhomocysteine deaminase activity
A16_47220	COG0402	S-adenosylhomocysteine deaminase activity
A16_47260	COG0444	Belongs to the ABC transporter superfamily
A16_47270	COG4608	Belongs to the ABC transporter superfamily
A16_47280	COG3275	phosphorelay sensor kinase activity
A16_47290	COG3279	Response regulator of the LytR AlgR family
A16_47320	COG1983	PspC domain protein
A16_47330	COG1396	sequence-specific DNA binding
A16_47340	COG0697	spore germination
A16_47360	COG1959	2 iron, 2 sulfur cluster binding
A16_47370	COG1668	transmembrane transport
A16_47380	COG4152	abc transporter atp-binding protein
A16_47390	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A16_47420	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A16_47430	COG1876	peptidase activity
A16_47440	COG0824	Thioesterase
A16_47450	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A16_47460	COG1053	succinate dehydrogenase
A16_47470	COG2009	succinate dehydrogenase
A16_47480	COG1719	4-vinyl reductase, 4VR
A16_47500	COG3118	belongs to the thioredoxin family
A16_47510	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A16_47520	COG2086	electron transfer activity
A16_47530	COG1024	Enoyl-CoA hydratase
A16_47540	COG1309	transcriptional regulator
A16_47550	COG0318	PFAM AMP-dependent synthetase and ligase
A16_47600	COG2318	DinB family
A16_47660	COG1131	(ABC) transporter
A16_47670	COG2205	protein histidine kinase activity
A16_47680	COG0745	RESPONSE REGULATOR receiver
A16_47700	COG4895	conserved protein (DUF2196)
A16_47710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A16_47740	COG4509	Sortase family
A16_47750	COG1120	ATPase activity
A16_47780	COG5386	Cell surface protein
A16_47800	COG5386	Cell surface protein
A16_47810	COG1114	Component of the transport system for branched-chain amino acids
A16_47820	COG1187	pseudouridine synthase activity
A16_47840	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A16_47840	COG1796	DNA polymerase
A16_47850	COG1286	toxin biosynthetic process
A16_47950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A16_47970	COG1418	mRNA catabolic process
A16_48020	COG2814	Major facilitator Superfamily
A16_48030	COG1566	PFAM secretion protein HlyD family protein
A16_48040	COG1309	transcriptional regulator
A16_48050	COG1363	Peptidase, m42
A16_48110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A16_48130	COG1484	DNA-dependent DNA replication
A16_48140	COG3611	Membrane attachment protein
A16_48160	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A16_48180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A16_48190	COG0237	dephospho-CoA kinase activity
A16_48200	COG1971	Probably functions as a manganese efflux pump
A16_48230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A16_48230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A16_48240	COG5002	protein histidine kinase activity
A16_48250	COG0745	RESPONSE REGULATOR receiver
A16_48300	COG0538	isocitrate dehydrogenase activity
A16_48310	COG0372	Belongs to the citrate synthase family
A16_48340	COG0628	permease
A16_48350	COG3030	protein affecting phage T7 exclusion by the F plasmid
A16_48400	COG1725	Transcriptional regulator
A16_48410	COG0281	malic enzyme
A16_48420	COG0587	DNA-directed DNA polymerase activity
A16_48450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A16_48500	COG4109	DRTGG domain
A16_48530	COG0006	proline dipeptidase activity
A16_48600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_48610	COG0662	Cupin 2, conserved barrel domain protein
A16_48630	COG1476	TRANSCRIPTIONal
A16_48660	COG1028	Short-chain dehydrogenase reductase Sdr
A16_48670	COG0589	response to stress
A16_48760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_48800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A16_48810	COG0827	DNA restriction-modification system
A16_48820	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A16_48830	COG3874	Sporulation protein YtfJ
A16_48850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A16_48860	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A16_48880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A16_48910	COG1104	cysteine desulfurase activity
A16_48940	COG0583	DNA-binding transcription factor activity
A16_48950	COG0697	spore germination
A16_48980	COG1956	GAF domain-containing protein
A16_48990	COG0626	cystathionine gamma-synthase activity
A16_49030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A16_49050	COG1595	DNA-templated transcription, initiation
A16_49070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A16_49080	COG0454	-acetyltransferase
A16_49090	COG0517	IMP dehydrogenase activity
A16_49100	COG0123	including yeast histone deacetylase and acetoin utilization protein
A16_49120	COG0745	RESPONSE REGULATOR receiver
A16_49140	COG0666	response to abiotic stimulus
A16_49210	COG1609	Transcriptional regulator
A16_49220	COG4851	CamS sex pheromone cAM373 precursor
A16_49230	COG3118	belongs to the thioredoxin family
A16_49250	COG2309	aminopeptidase activity
A16_49290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_49350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A16_49360	COG4848	Belongs to the UPF0354 family
A16_49370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16_49380	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A16_49390	COG1363	Peptidase, m42
A16_49410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_49440	COG0510	thiamine kinase activity
A16_49450	COG1523	belongs to the glycosyl hydrolase 13 family
A16_49470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A16_49480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A16_49490	COG1349	DNA-binding transcription factor activity
A16_49500	COG1187	pseudouridine synthase activity
A16_49510	COG2244	polysaccharide biosynthetic process
A16_49520	COG2081	HI0933 family
A16_49540	COG2814	Major facilitator Superfamily
A16_49560	COG3832	glyoxalase III activity
A16_49600	COG1329	Transcriptional regulator
A16_49620	COG4975	Glucose uptake
A16_49650	COG0314	molybdopterin synthase activity
A16_49660	COG1763	Mo-molybdopterin cofactor biosynthetic process
A16_49670	COG0303	'Molybdopterin
A16_49690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A16_49750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16_49770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A16_49880	COG2814	Major facilitator Superfamily
A16_49890	COG0475	glutathione-regulated potassium exporter activity
A16_49900	COG0490	domain, Protein
A16_49910	COG0582	viral genome integration into host DNA
A16_49940	COG1136	(ABC) transporter
A16_49980	COG1242	4 iron, 4 sulfur cluster binding
A16_49990	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A16_50000	COG1131	(ABC) transporter
A16_50020	COG1794	racemase activity, acting on amino acids and derivatives
A16_50070	COG2267	carboxylic ester hydrolase activity
A16_50080	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A16_50090	COG0671	phosphoesterase, PA-phosphatase related
A16_50100	COG0438	transferase activity, transferring glycosyl groups
A16_50120	COG0521	Mo-molybdopterin cofactor biosynthetic process
A16_50220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A16_50230	COG5002	protein histidine kinase activity
A16_50240	COG4191	Histidine kinase
A16_50250	COG2267	carboxylic ester hydrolase activity
A16_50300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A16_50310	COG1116	anion transmembrane transporter activity
A16_50320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A16_50370	COG0494	nUDIX hydrolase
A16_50430	COG0288	reversible hydration of carbon dioxide
A16_50440	COG1271	oxidase subunit
A16_50450	COG1294	oxidase, subunit
A16_50490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_50540	COG1842	Phage shock protein A
A16_50600	COG5002	protein histidine kinase activity
A16_50610	COG0745	RESPONSE REGULATOR receiver
A16_50670	COG1597	lipid kinase activity
A16_50740	COG0586	Pfam SNARE associated Golgi protein
A16_50760	COG0577	efflux transmembrane transporter activity
A16_50770	COG1136	(ABC) transporter
A16_50780	COG2207	Transcriptional regulator
A16_50780	COG3708	Transcriptional regulator
A16_50790	COG0745	RESPONSE REGULATOR receiver
A16_50800	COG2205	protein histidine kinase activity
A16_50810	COG0577	efflux transmembrane transporter activity
A16_50840	COG0577	efflux transmembrane transporter activity
A16_50850	COG1136	(ABC) transporter
A16_50940	COG3964	amidohydrolase
A16_51020	COG4948	Mandelate Racemase Muconate Lactonizing
A16_51040	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A16_51070	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A16_51080	COG1169	isochorismate synthase
A16_51090	COG1575	Belongs to the MenA family. Type 1 subfamily
A16_51100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A16_51110	COG1278	Cold shock
A16_51150	COG0058	SHG alpha-glucan phosphorylase activity
A16_51160	COG0297	glycogen (starch) synthase activity
A16_51170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A16_51180	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A16_51200	COG0039	L-malate dehydrogenase activity
A16_51390	COG0544	peptidyl-prolyl cis-trans isomerase activity
A16_51460	COG1285	pathogenesis
A16_51470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A16_51490	COG0166	Belongs to the GPI family
A16_51500	COG2155	Conserved Protein
A16_51510	COG1098	S1 RNA binding domain
A16_51520	COG0436	Aminotransferase
A16_51530	COG1522	sequence-specific DNA binding
A16_51540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A16_51550	COG2267	carboxylic ester hydrolase activity
A16_51570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A16_51610	COG5018	Exonuclease
A16_51620	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A16_51660	COG0423	glycine-tRNA ligase activity
A16_51670	COG2050	protein possibly involved in aromatic compounds catabolism
A16_51690	COG1268	BioY protein
A16_51710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A16_51720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A16_51760	COG3584	3D domain protein
A16_51790	COG1252	NADH dehydrogenase
A16_51820	COG3708	Transcriptional regulator
A16_51850	COG1683	Conserved Protein
A16_51890	COG0316	Belongs to the HesB IscA family
A16_51920	COG1252	NADH dehydrogenase
A16_51950	COG0390	transport system, permease component
A16_51960	COG2824	Alkylphosphonate utilization operon protein PhnA
A16_52040	COG4837	Protein of unknown function (DUF1462)
A16_52050	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A16_52070	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A16_52080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A16_52100	COG2249	NAD(P)H dehydrogenase (quinone) activity
A16_52110	COG0647	UMP catabolic process
A16_52130	COG2445	Protein of unknown function DUF86
A16_52140	COG1494	fructose-1,6-bisphosphatase
A16_52170	COG4470	Protein conserved in bacteria
A16_52190	COG0789	Transcriptional regulator
A16_52200	COG4377	Putative membrane peptidase family (DUF2324)
A16_52250	COG0739	heme binding
A16_52270	COG3377	Domain of unknown function (DUF1805)
A16_52310	COG1695	Transcriptional regulator
A16_52330	COG0719	Fe-S assembly protein
A16_52340	COG0822	iron-sulfur transferase activity
A16_52350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A16_52380	COG0396	ATPase activity
A16_52390	COG1464	Belongs to the NlpA lipoprotein family
A16_52400	COG1464	Belongs to the NlpA lipoprotein family
A16_52410	COG2011	ABC-type metal ion transport system permease component
A16_52420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A16_52450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16_52460	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A16_52480	COG1393	Belongs to the ArsC family
A16_52560	COG0039	L-malate dehydrogenase activity
A16_52600	COG1309	transcriptional regulator
A16_52610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_52620	COG1960	acyl-CoA dehydrogenase activity
A16_52640	COG0183	Belongs to the thiolase family
A16_52650	COG1024	Enoyl-CoA hydratase
A16_52650	COG1250	3-hydroxyacyl-CoA dehydrogenase
A16_52670	COG1686	Belongs to the peptidase S11 family
A16_52700	COG0011	TIGRFAM Protein of
A16_52710	COG0840	transmembrane signaling receptor activity
A16_52760	COG2814	Major facilitator Superfamily
A16_52770	COG0531	amino acid
A16_52790	COG0706	membrane insertase activity
A16_52810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_52880	COG0586	Pfam SNARE associated Golgi protein
A16_52900	COG1376	ErfK ybiS ycfS ynhG family protein
A16_52910	COG0745	RESPONSE REGULATOR receiver
A16_52920	COG5002	protein histidine kinase activity
A16_52940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A16_52970	COG2151	metal-sulfur cluster biosynthetic enzyme
A16_52980	COG3227	Zinc metalloprotease (Elastase)
A16_52990	COG1741	Belongs to the pirin family
A16_53020	COG0475	glutathione-regulated potassium exporter activity
A16_53030	COG0490	domain, Protein
A16_53040	COG1115	amino acid carrier protein
A16_53050	COG0783	Belongs to the Dps family
A16_53090	COG1611	Belongs to the LOG family
A16_53120	COG2311	Membrane
A16_53140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16_53150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16_53160	COG1115	amino acid carrier protein
A16_53170	COG1115	amino acid carrier protein
A16_53180	COG2910	NAD(P)H-binding
A16_53230	COG0656	L-ascorbic acid biosynthetic process
A16_53240	COG2814	Major facilitator Superfamily
A16_53250	COG1733	regulation of RNA biosynthetic process
A16_53270	COG1252	NADH dehydrogenase
A16_53280	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A16_53290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A16_53310	COG0840	transmembrane signaling receptor activity
A16_53310	COG3290	protein histidine kinase activity
A16_53330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A16_53340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A16_53370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_53380	COG3223	Belongs to the PsiE family
A16_53480	COG0557	exoribonuclease II activity
A16_53490	COG1647	Serine aminopeptidase, S33
A16_53500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A16_53510	COG1346	cytolysis
A16_53710	COG4695	Portal protein
A16_53760	COG4974	Belongs to the 'phage' integrase family
A16_53780	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A16_53790	COG0149	triose-phosphate isomerase activity
A16_53810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A16_53840	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A16_53890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16_53920	COG2323	membrane
A16_53930	COG0740	serine-type endopeptidase activity
A16_53940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A16_53960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A16_53980	COG1051	belongs to the nudix hydrolase family
A16_54000	COG0492	ferredoxin-NADP+ reductase activity
A16_54010	COG0457	Tetratricopeptide repeat
A16_54020	COG0110	maltose O-acetyltransferase activity
A16_54060	COG1950	PFAM Membrane protein of
A16_54080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A16_54090	COG0556	nucleotide-excision repair
A16_54130	COG0789	Transcriptional regulator
A16_54180	COG2855	membrane
A16_54190	COG0583	DNA-binding transcription factor activity
A16_54210	COG0655	NAD(P)H dehydrogenase (quinone) activity
A16_54240	COG1132	(ABC) transporter
A16_54250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A16_54260	COG0793	Belongs to the peptidase S41A family
A16_54260	COG3409	Peptidoglycan-binding domain 1 protein
A16_54270	COG2177	Part of the ABC transporter FtsEX involved in
A16_54280	COG2884	Cell division ATP-binding protein ftsE
A16_54310	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A16_54340	COG0653	protein targeting
A16_54350	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A16_54370	COG1278	Cold shock
A16_54380	COG1040	competence protein
A16_54410	COG0791	NLP P60 protein
A16_54410	COG1388	LysM domain
A16_54420	COG1733	regulation of RNA biosynthetic process
A16_54430	COG1307	EDD domain protein, DegV family
A16_54440	COG1739	Uncharacterized protein family UPF0029
A16_54450	COG1316	TRANSCRIPTIONal
A16_54460	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A16_54470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A16_54480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A16_54500	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A16_54500	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A16_54530	COG3394	polysaccharide catabolic process
A16_54540	COG1486	melibiose metabolic process
A16_54550	COG1447	Phosphotransferase system cellobiose-specific component IIA
A16_54560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A16_54580	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A16_54590	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A16_54600	COG1447	Phosphotransferase system cellobiose-specific component IIA
A16_54620	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A16_54630	COG1301	dicarboxylic acid transport
A16_54650	COG0346	lactoylglutathione lyase activity
A16_54660	COG1511	domain protein
A16_54670	COG0583	DNA-binding transcription factor activity
A16_54680	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A16_54730	COG1271	oxidase subunit
A16_54740	COG1294	oxidase, subunit
A16_54750	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A16_54770	COG1620	l-lactate permease
A16_54790	COG2389	metal-binding protein
A16_54810	COG1368	sulfuric ester hydrolase activity
A16_54860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16_54910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A16_54920	COG3584	3D domain protein
A16_54920	COG1388	LysM domain
A16_54970	COG4715	Zinc finger, swim domain protein
A16_54980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A16_55040	COG1191	sigma factor activity
A16_55060	COG0577	efflux transmembrane transporter activity
A16_55070	COG1136	(ABC) transporter
A16_55140	COG5002	protein histidine kinase activity
A16_55150	COG0745	RESPONSE REGULATOR receiver
A16_55160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A16_55200	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A16_55210	COG1134	teichoic acid transport
A16_55220	COG1682	transport, permease protein
A16_55230	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A16_55350	COG0739	heme binding
A16_55380	COG3279	Response regulator of the LytR AlgR family
A16_55390	COG4555	ABC transporter
A16_55400	COG2385	sporulation resulting in formation of a cellular spore
A16_55410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A16_55430	COG4836	Membrane
A16_55440	COG1007	ATP synthesis coupled electron transport
A16_55450	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A16_55460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A16_55480	COG0839	Belongs to the complex I subunit 6 family
A16_55510	COG0649	NAD binding
A16_55520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A16_55540	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A16_55550	COG3300	MHYT domain
A16_55550	COG5001	Diguanylate cyclase
A16_55650	COG0356	it plays a direct role in the translocation of protons across the membrane
A16_55720	COG0698	ribose 5-phosphate isomerase
A16_55740	COG2190	(PTS) system
A16_55750	COG2259	Doxx family
A16_55760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A16_55790	COG0009	L-threonylcarbamoyladenylate synthase
A16_55820	COG2890	protein-(glutamine-N5) methyltransferase activity
A16_55830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A16_55860	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A16_55870	COG1494	fructose-1,6-bisphosphatase
A16_55880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A16_55910	COG4821	SIS domain
A16_55930	COG3343	RNA polymerase activity
A16_55950	COG1960	acyl-CoA dehydrogenase activity
A16_55960	COG1960	acyl-CoA dehydrogenase activity
A16_55970	COG1250	3-hydroxyacyl-CoA dehydrogenase
A16_55980	COG0183	Belongs to the thiolase family
A16_55990	COG2181	nitrate reductase activity
A16_55990	COG0247	lactate metabolic process
A16_56000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A16_56020	COG5001	Diguanylate cyclase
A16_56020	COG3300	MHYT domain
A16_56060	COG2197	response regulator
A16_56070	COG4585	Histidine kinase
A16_56080	COG0842	Transport permease protein
A16_56090	COG1131	(ABC) transporter
A16_56100	COG0024	Methionine aminopeptidase
A16_56160	COG2234	aminopeptidase activity
A16_56200	COG1595	DNA-templated transcription, initiation
A16_56230	COG4506	Protein conserved in bacteria
A16_56240	COG1619	proteins homologs of microcin C7 resistance protein MccF
A16_56280	COG0010	Belongs to the arginase family
A16_56290	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A16_56300	COG2814	Major facilitator Superfamily
A16_56310	COG0789	Transcriptional regulator
A16_56330	COG0584	glycerophosphoryl diester phosphodiesterase
A16_56340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16_56360	COG1994	Peptidase M50
A16_56380	COG1078	dGTPase activity
A16_56390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_56400	COG1120	ATPase activity
A16_56410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_56430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_56470	COG0095	Lipoate-protein ligase
A16_56480	COG0280	phosphate acetyltransferase
A16_56510	COG3773	Cell wall hydrolase
A16_56530	COG2363	Small membrane protein
A16_56570	COG2233	PERMEase
A16_56580	COG0561	phosphatase activity
A16_56590	COG2814	Major facilitator Superfamily
A16_56610	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A16_56620	COG1131	(ABC) transporter
A16_56630	COG2755	lipolytic protein G-D-S-L family
A16_56640	COG1609	Transcriptional regulator
A16_56660	COG0460	homoserine dehydrogenase
A16_56700	COG1011	Hydrolase
A16_56710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A16_56730	COG2197	response regulator
A16_56760	COG0351	phosphomethylpyrimidine kinase
A16_56770	COG3706	GGDEF domain
A16_56780	COG2879	small protein
A16_56790	COG1966	Carbon starvation protein
A16_56800	COG3279	Response regulator of the LytR AlgR family
A16_56820	COG0477	Major facilitator Superfamily
A16_56870	COG0840	transmembrane signaling receptor activity
A16_56890	COG1607	acyl-coa hydrolase
A16_56920	COG0488	(ABC) transporter
A16_56980	COG0463	Glycosyl transferase, family 2
A16_56990	COG1309	transcriptional regulator
A16_57000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A16_57010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A16_57010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A16_57030	COG0628	permease
A16_57060	COG3279	Response regulator of the LytR AlgR family
A16_57070	COG3275	phosphorelay sensor kinase activity
A16_57080	COG2814	Major facilitator Superfamily
A16_57090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A16_57100	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
A16_57110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A16_57150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A16_57160	COG1272	protein, Hemolysin III
A16_57200	COG0516	GMP reductase activity
A16_57210	COG1164	Oligoendopeptidase f
A16_57250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A16_57260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A16_57270	COG4853	Protein conserved in bacteria
A16_57300	COG5002	protein histidine kinase activity
A16_57310	COG0745	RESPONSE REGULATOR receiver
A16_57370	COG0305	Participates in initiation and elongation during chromosome replication
A16_57390	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A16_57400	COG4241	membrane
A16_57420	COG0629	single-stranded DNA binding
A16_57440	COG0012	GTP binding
A16_57450	COG4481	Protein conserved in bacteria
A16_57460	COG0668	transmembrane transport
A16_57480	COG1475	DNA binding
A16_57490	COG1192	Involved in chromosome partitioning
A16_57530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A16_57540	COG1847	R3H domain protein
A16_57550	COG0706	membrane insertase activity
A16_57580	COG0542	response to heat
A16_57585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A16_57600	COG4856	YbbR-like protein
A16_57685	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
A16_57710	COG1396	sequence-specific DNA binding
A16_57730	COG0582	viral genome integration into host DNA
A16_57790	COG0346	lactoylglutathione lyase activity
A16_57795	COG2226	methyltransferase
A16_57800	COG4548	von Willebrand factor, type A
A16_57805	COG2188	Transcriptional regulator
A16_57815	COG1609	Transcriptional regulator
A16_57820	COG0833	amino acid
A16_57985	COG4608	Belongs to the ABC transporter superfamily
A16_58000	COG0772	Belongs to the SEDS family
A16_58030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A16_58035	COG3243	poly(R)-hydroxyalkanoic acid synthase
A16_58205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A16_58240	COG1073	alpha beta
A16_58275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16_58395	COG1674	ftsk spoiiie
A16_58415	COG0546	phosphoglycolate phosphatase activity
A16_58445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16_58665	COG4667	esterase of the alpha-beta hydrolase superfamily
A16_58680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A16_58815	COG3239	Fatty acid desaturase
A16_58820	COG3279	Response regulator of the LytR AlgR family
A16_58840	COG0463	Glycosyl transferase, family 2
A16_58860	COG0714	Associated with various cellular activities
A16_58870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16_58885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16_58890	COG0784	Response regulator, receiver
A16_58920	COG2169	Transcriptional regulator
A16_58970	COG0738	Major facilitator superfamily
A16_59020	COG2226	methyltransferase
A16_59065	COG3152	Membrane
A16_59155	COG1396	sequence-specific DNA binding
A16_59225	COG1396	sequence-specific DNA binding
A16_59245	COG0242	peptide deformylase activity
A16_59375	COG1534	Rna-binding protein
A16_59385	COG1404	Belongs to the peptidase S8 family
A16_59425	COG0017	Asparaginyl-tRNA synthetase
A16_59430	COG0072	phenylalanine-tRNA ligase activity
A16_59430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A16_59435	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A16_59440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A16_59470	COG1674	ftsk spoiiie
A16_59530	COG0596	Alpha beta hydrolase
A16_59565	COG0737	Belongs to the 5'-nucleotidase family
A16_59575	COG0719	Fe-S assembly protein
A16_59630	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A16_59660	COG1609	Transcriptional regulator
A16_59665	COG0018	arginyl-trna synthetase
A16_59670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_59690	COG4863	YycH protein
A16_59740	COG3344	reverse transcriptase
A16_59820	COG3344	reverse transcriptase
A16_60030	COG4962	Type ii secretion system protein e
A16_60165	COG2311	Membrane
A16_60190	COG4196	transglutaminase domain protein
A16_60195	COG0671	phosphoesterase, PA-phosphatase related
A16_60220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A16_60225	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A16_60240	COG2801	Transposase and inactivated derivatives
A16_60395	COG2002	toxin-antitoxin pair type II binding
A16_60405	COG4974	Belongs to the 'phage' integrase family
A16_60445	COG2801	Transposase and inactivated derivatives
A16_60465	COG3443	Belongs to the bacterial solute-binding protein 9 family
A16_60475	COG4974	Belongs to the 'phage' integrase family
A16_60500	COG0457	Tetratricopeptide repeat
A16_60505	COG1923	regulation of RNA biosynthetic process
A16_60585	COG0791	NLP P60 protein
A16_60585	COG0741	lytic transglycosylase activity
A16_60730	COG1192	Involved in chromosome partitioning
A16_60750	COG2801	Transposase and inactivated derivatives
A16_60775	COG1683	Conserved Protein
A16_60780	COG1309	transcriptional regulator
A16_60850	COG0681	Belongs to the peptidase S26 family
A16_60880	COG1280	lysine exporter protein (LysE YggA)
A16_60915	COG4166	transmembrane transport
A16_60930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A16_60990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A16_60995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone