locus-tag class description BA_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BA_0003 ENOG410848D S4 domain protein YaaA BA_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BA_0008 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BA_0014 ENOG4105ZMH deoxynucleoside kinase BA_0016 ENOG4105GTG Isochorismatase BA_0018 ENOG4108Z6B deaminase BA_0019 ENOG4105C6E dna polymerase iii BA_0024 ENOG41067KS pro-sigma K processing BA_0026 ENOG4105CXN decarboxylase BA_0028 ENOG4105FA2 dna polymerase iii BA_0029 ENOG4105MA4 psp1 domain protein BA_0031 ENOG41060K3 Methyltransferase BA_0033 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BA_0034 ENOG4105KRN Transcriptional regulator, abrb family BA_0037 ENOG4105F8V Hydrolase, tatD family BA_0038 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BA_0040 ENOG4105XFA sporulation peptidase YabG BA_0041 ENOG4105W42 Veg protein BA_0044 ENOG4105DFT pur operon repressor BA_0046 ENOG4105KME endoribonuclease L-psp BA_0049 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BA_0050 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BA_0052 ENOG4108JA2 transcriptioN-repair coupling factor BA_0053 ENOG4108M14 stage v sporulation protein t BA_0055 ENOG4108IY2 MazG family BA_0056 ENOG41082I2 s4 domain protein BA_0057 ENOG4105VYY sporulation protein yabp BA_0060 ENOG41060GV RNA binding s1 domain protein BA_0062 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BA_0063 ENOG4108UGV hypoxanthine phosphoribosyltransferase BA_0064 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BA_0067 ENOG4105C6T cysteine synthase BA_0068 ENOG4105CRQ synthase (Component I) BA_0069 ENOG4105DDQ anthranilate synthase BA_0070 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BA_0071 ENOG4105EEI dihydropteroate synthase BA_0072 ENOG4105KRF dihydroneopterin aldolase BA_0073 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BA_0075 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BA_0078 ENOG4108Z0C Uvrb UvrC protein BA_0081 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BA_0083 ENOG4105CTP PilT protein domain protein BA_0088 ENOG4105D7W serine acetyltransferase BA_0091 ENOG4105C2N RNA methyltransferase TrmH family group 3 BA_0092 ENOG4105M0M Tetracycline resistance protein BA_0093 ENOG4105QIV RNA polymerase BA_0096 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BA_0101 ENOG4107Y49 methyltransferase BA_0103 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BA_0104 ENOG4105XPM ribosomal protein BA_0125 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BA_0130 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BA_0132 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BA_0134 ENOG41067V7 50S ribosomal protein L36 BA_0140 ENOG4108JJB ABC transporter BA_0141 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BA_0142 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BA_0147 ENOG4105D1F ATP-binding protein BA_0150 ENOG4108NMV polysaccharide deacetylase BA_0155 ENOG4105C8B TIGR00159 family BA_0156 ENOG4107U5W ybbr family BA_0159 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BA_0160 ENOG4108VQT Alpha beta hydrolase fold protein BA_0164 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BA_0165 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BA_0173 ENOG4108UMI ABC transporter, permease BA_0174 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BA_0175 ENOG4105D01 (LipO)protein BA_0176 ENOG4105EE1 crotonyl-CoA reductase BA_0178 ENOG4105IQ5 FAD linked oxidase domain protein BA_0181 ENOG4105C2C drug resistance transporter, Bcr CflA BA_0185 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BA_0186 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BA_0187 ENOG4105C3U ABC transporter BA_0188 ENOG4108JQ7 (ABC) transporter BA_0194 ENOG4108J59 Extracellular solute-binding protein, family 5 BA_0195 ENOG4108J59 Extracellular solute-binding protein, family 5 BA_0197 ENOG4105II7 pyrroline-5-carboxylate reductase BA_0199 ENOG4107XDY Nicotinamide Mononucleotide Transporter BA_0202 ENOG4105E0C molybdate abc transporter BA_0205 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BA_0208 ENOG4105EGI Transcriptional regulator BA_0213 ENOG4105F6E Acyl-transferase BA_0218 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BA_0222 ENOG4108RE7 deoxyribonuclease BA_0223 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BA_0228 ENOG4105C5H ABC transporter BA_0231 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BA_0233 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BA_0234 ENOG4105C3U ABC transporter BA_0235 ENOG4108JQ7 (ABC) transporter BA_0240 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BA_0241 ENOG4105ERH Fumarylacetoacetate hydrolase BA_0244 ENOG4108SC4 )-transporter BA_0246 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BA_0249 ENOG4107ZXI Rhomboid family BA_0251 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BA_0252 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BA_0254 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BA_0258 ENOG4105K8N protein family UPF0079, ATPase BA_0259 ENOG41072GX Peptidase M22 Glycoprotease BA_0260 ENOG410801F ribosomal-protein-alanine acetyltransferase BA_0261 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BA_0262 ENOG4105C5H ABC transporter BA_0265 ENOG4108TYN CAAX amino terminal protease family protein BA_0270 ENOG4105C7N Xanthine uracil vitamin C permease BA_0272 ENOG4105BZU Histidine kinase BA_0275 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BA_0280 ENOG4108SHN Glycosyl transferase, family 2 BA_0283 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BA_0287 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BA_0288 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BA_0289 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BA_0290 ENOG4105C83 adenylosuccinate lyase BA_0292 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BA_0297 ENOG4108V3E phosphoribosylglycinamide formyltransferase BA_0299 ENOG4105C12 Phosphoribosylglycinamide synthetase BA_0305 ENOG4105C4R Atp-dependent dna helicase BA_0311 ENOG4108W2Y isochorismatase BA_0312 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BA_0313 ENOG4108UMI ABC transporter, permease BA_0314 ENOG4105D01 (LipO)protein BA_0318 ENOG410834F Transcriptional regulator BA_0323 ENOG4105CBD Diacylglycerol kinase BA_0324 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BA_0325 ENOG4108JPW Aminotransferase BA_0327 ENOG4105C26 Dehydrogenase BA_0328 ENOG4105KPY Small multidrug resistance protein BA_0332 ENOG4105D9N nucleoside BA_0333 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BA_0336 ENOG4108W15 Protein of unknown function (DUF1456) BA_0339 ENOG4105DTQ mandelate racemase muconate lactonizing BA_0341 ENOG4105DFD Na H antiporter BA_0345 ENOG4105D3R alkyl hydroperoxide reductase BA_0346 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BA_0348 ENOG4107W7X Aldolase BA_0349 ENOG4105EHG Permease protein BA_0350 ENOG4105DQ5 transport system permease protein BA_0351 ENOG4108V5C ABC transporter BA_0363 ENOG410756H nucleotidyltransferase BA_0364 ENOG4105D2S major facilitator superfamily BA_0369 ENOG4105C8Q Methyl-accepting chemotaxis BA_0370 ENOG4105C8Q Methyl-accepting chemotaxis BA_0372 ENOG4105CI1 PTS System BA_0378 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BA_0381 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BA_0384 ENOG4105C5H ABC transporter BA_0389 ENOG41062JF Transcriptional regulator BA_0393 ENOG4105DEU major facilitator superfamily BA_0396 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BA_0399 ENOG4108N0M stress protein BA_0400 ENOG4106FN3 tellurium resistance protein BA_0401 ENOG4106FN3 tellurium resistance protein BA_0402 ENOG4107TS3 membrane protein, TerC BA_0403 ENOG4108TTB tellurium resistance protein BA_0407 ENOG4105KJF protein tyrosine phosphatase BA_0409 ENOG4107U9T Pfam:Ribonuclease_BN BA_0410 ENOG4105C59 p-type ATPase BA_0411 ENOG4108IPJ Membrane BA_0415 ENOG4107ZTW SNARE associated Golgi BA_0418 ENOG410606W general stress protein BA_0419 ENOG4105UPD Calcium Proton BA_0426 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BA_0427 ENOG4105VTR Integrase BA_0428 ENOG4108IMY Transcriptional regulator BA_0487 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BA_0489 ENOG4108JUB Transcriptional regulator BA_0492 ENOG4108IQI permease BA_0499 ENOG4105CSV Glutaminase BA_0502 ENOG4108A04 Beta-lactamase BA_0505 ENOG4105CKK Glycosyl transferase, family 2 BA_0507 ENOG4105C3I Nad-dependent epimerase dehydratase BA_0510 ENOG4105F1A Pyruvate formate-lyase BA_0514 ENOG4105CI2 imidazolone-5-propionate hydrolase BA_0515 ENOG4105ECP epimerase BA_0521 ENOG41067AE Membrane-bound metal-dependent hydrolase BA_0522 ENOG4105CEN a g-specific adenine glycosylase BA_0523 ENOG4106BXE BA_0528 ENOG4105BZ1 (ABC) transporter BA_0529 ENOG4107NBY Membrane BA_0530 ENOG4105CBC glutamate synthase BA_0532 ENOG4108IUW ABC transporter BA_0536 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BA_0537 ENOG4105G5W regulator Fur family BA_0543 ENOG4108JQC penicillin-binding protein 1A BA_0544 ENOG4107ZQN disulfide bond BA_0545 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BA_0547 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BA_0548 ENOG4105BZU Histidine kinase BA_0550 ENOG4105CYN Serine protein kinase BA_0554 ENOG4105C94 Transporter BA_0557 ENOG4105DZ6 Band 7 protein BA_0559 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BA_0561 ENOG4105D4T Citrate transporter BA_0565 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BA_0566 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BA_0567 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BA_0568 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BA_0569 ENOG4105BZ7 extracellular solute-binding protein family 1 BA_0570 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BA_0571 ENOG4108STX response regulator BA_0572 ENOG4105US7 Histidine kinase BA_0577 ENOG4108MRH transcriptional regulatory protein BA_0579 ENOG4105C6K Malic enzyme BA_0581 ENOG4108UZ3 Transporter BA_0582 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BA_0584 ENOG4105BZU Histidine kinase BA_0585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA_0587 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BA_0588 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BA_0589 ENOG4108JB9 formate dehydrogenase BA_0593 ENOG4105CUB amino acid BA_0595 ENOG4105C59 p-type ATPase BA_0596 ENOG4105DAP Nicotinate phosphoribosyltransferase BA_0604 ENOG41073R8 VanW family BA_0605 ENOG4108KGH TRANSCRIPTIONal BA_0606 ENOG4105D9N nucleoside BA_0607 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BA_0608 ENOG4105C37 (CBS) domain BA_0609 ENOG4108IJ0 Aspartate ammonia-lyase BA_0610 ENOG4105DAA L-lactate BA_0614 ENOG4105DUX Transporter BA_0615 ENOG4108MES Periplasmic binding protein BA_0616 ENOG4105DQ5 transport system permease protein BA_0617 ENOG4108IHU transport system permease protein BA_0618 ENOG4105E0A ABC, transporter BA_0619 ENOG4105DMQ Methyltransferase BA_0621 ENOG4105EXW epimerase dehydratase BA_0623 ENOG4107T89 von Willebrand factor, type A BA_0624 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BA_0625 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BA_0628 ENOG4105BZU Histidine kinase BA_0629 ENOG4105D5Q Arginine ornithine antiporter BA_0630 ENOG4107414 GntR family transcriptional regulator BA_0631 ENOG4105C5Y PTS System BA_0632 ENOG4105CG3 alpha amylase, catalytic region BA_0635 ENOG4105E1K spore germination protein BA_0637 ENOG4105CRN Aminoglycoside phosphotransferase BA_0638 ENOG4105BZG amino acid carrier protein BA_0639 ENOG4105CDA abc transporter atp-binding protein BA_0640 ENOG4105CT1 (ABC) transporter BA_0641 ENOG4105EAD ABC transporter BA_0642 ENOG4105DRP amino acid AbC transporter BA_0643 ENOG4108IQI permease BA_0648 ENOG4105D29 Helix-turn-helix type 11 domain protein BA_0649 ENOG4105NAE bifunctional deaminase-reductase domain protein BA_0650 ENOG4105BZU Histidine kinase BA_0653 ENOG4105CHH sulfate transporter BA_0654 ENOG41068KF Universal stress protein BA_0656 ENOG4105DEF Extracellular solute-binding protein, family 5 BA_0658 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BA_0659 ENOG4108JQ7 (ABC) transporter BA_0661 ENOG4105CXY transporter BA_0662 ENOG41067TZ transcriptional regulator, MarR family BA_0664 ENOG4105ETE Transcriptional regulator (LacI family BA_0665 ENOG4108RVA ribokinase BA_0667 ENOG4105C2J ABC transporter BA_0668 ENOG4105CNN ABC, transporter BA_0669 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BA_0670 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BA_0683 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BA_0684 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BA_0685 ENOG41069ER domain protein BA_0686 ENOG4105VZ8 Transcriptional regulator BA_0687 ENOG4107D63 BA_0689 ENOG4105DUX Transporter BA_0693 ENOG4105C85 amino acid BA_0694 ENOG4105C7N Xanthine uracil vitamin C permease BA_0702 ENOG4105BZ9 Cytochrome C oxidase, subunit I BA_0703 ENOG4105E2S oxidase) subunit II BA_0704 ENOG4108IQI permease BA_0707 ENOG4106CAD Protein of unknown function (DUF3311) BA_0708 ENOG4105E1V na solute symporter BA_0711 ENOG4108NHD germination protein BA_0714 ENOG4105CE1 Ferrous iron transport protein b BA_0715 ENOG4105CVA phosphate BA_0716 ENOG4105C8U phosphate abc transporter BA_0717 ENOG4105E2Z phosphate ABC transporter (Permease BA_0720 ENOG41080XQ Signal transduction protein with cbs domains BA_0725 ENOG4105ETU transcriptional activator (TenA BA_0727 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BA_0729 ENOG4108VEU Thiamine monophosphate synthase BA_0730 ENOG41080HI glycine oxidase BA_0733 ENOG4105D06 uba thif-type nad fad binding protein BA_0734 ENOG4105DWF phosphomethylpyrimidine kinase BA_0744 ENOG4108INS Transcriptional regulator BA_0747 ENOG4105C7N Xanthine uracil vitamin C permease BA_0754 ENOG4105C5Y PTS System BA_0766 ENOG4107Y03 Nitroreductase BA_0767 ENOG4105ED1 spovr family BA_0774 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BA_0775 ENOG4105XTG Pfam:DUF156 BA_0776 ENOG4105VFE sira family BA_0777 ENOG4107TPS domain protein BA_0778 ENOG4105VFE sira family BA_0779 ENOG41085GJ domain protein BA_0781 ENOG41087NI Sulfite exporter TauE/SafE BA_0783 ENOG4108KGH TRANSCRIPTIONal BA_0790 ENOG4105EMD TRANSCRIPTIONal BA_0791 ENOG4105VCP PTS System BA_0792 ENOG4105VZJ PTS System BA_0796 ENOG41069ER domain protein BA_0797 ENOG4107RBB ABC transporter, permease BA_0798 ENOG4105C19 ABC transporter BA_0803 ENOG4105WEF catalase BA_0810 ENOG4107T5V SNARE associated Golgi BA_0818 ENOG4105CUB amino acid BA_0819 ENOG4107RWR Sodium hydrogen exchanger BA_0821 ENOG4106KNT transcriptional regulator BA_0829 ENOG4108PCN EamA-like transporter family BA_0830 ENOG4108YXU transcriptional regulator AsnC family BA_0832 ENOG4105KPY Small multidrug resistance protein BA_0833 ENOG4105KPY Small multidrug resistance protein BA_0838 ENOG4105NF4 modulator of drug activity BA_0839 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BA_0840 ENOG4105E5W Transporter BA_0842 ENOG4107RKG DJ-1/PfpI family BA_0843 ENOG4105CH6 catalase BA_0845 ENOG4105D5Q Arginine ornithine antiporter BA_0847 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BA_0849 ENOG4105C26 Dehydrogenase BA_0852 ENOG4105BZ1 (ABC) transporter BA_0856 ENOG4105DRP amino acid AbC transporter BA_0857 ENOG4105CDA abc transporter atp-binding protein BA_0860 ENOG410839P BA_0867 ENOG4107FQX Alpha-acetolactate decarboxylase BA_0872 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BA_0875 ENOG4105D4P Coproporphyrinogen iii oxidase BA_0878 ENOG4105CHH sulfate transporter BA_0887 ENOG4106AKK s-layer domain-containing protein BA_0889 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BA_0890 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BA_0894 ENOG4105CGU Enoyl-CoA hydratase BA_0897 ENOG4105DER m42 family BA_0901 ENOG4105CTU Proline racemase BA_0910 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BA_0912 ENOG4108JQ7 (ABC) transporter BA_0921 ENOG4105CSH Transporter BA_0924 ENOG4108MRH transcriptional regulatory protein BA_0934 ENOG4105CDU Replicative dna helicase BA_0944 ENOG4105C0R drug resistance transporter emrb qaca subfamily BA_0954 ENOG4107P5I polyketide synthase BA_0955 ENOG4108IG5 Transcriptional regulator BA_0959 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BA_0963 ENOG4105CMT Dihydroxyacetone kinase BA_0965 ENOG4105CMT Dihydroxyacetone kinase BA_0966 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BA_0967 ENOG410847I Transcriptional regulator, BadM Rrf2 family BA_0975 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BA_0990 ENOG4105WN5 stage II sporulation protein BA_0992 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA_0994 ENOG4108MJI response regulator BA_0995 ENOG4105BZU Histidine kinase BA_0996 ENOG4105BZU Histidine kinase BA_1001 ENOG4105K8R UPF0145 protein BA_1008 ENOG4107VRP DNA repair exonuclease BA_1009 ENOG4106D4I domain protein BA_1010 ENOG4105D7V transposase BA_1013 ENOG4108IND Tetr family transcriptional regulator BA_1014 ENOG4105EQ0 Major Facilitator superfamily BA_1019 ENOG4108MUZ hydrolase BA_1024 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BA_1027 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BA_1032 ENOG4105EMN RNA polymerase sigma factor BA_1037 ENOG4105C57 major facilitator superfamily BA_1038 ENOG4105C0R drug resistance transporter emrb qaca subfamily BA_1040 ENOG4105EEM helicase BA_1041 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BA_1047 ENOG4105K59 histidine triad (HIT) protein BA_1054 ENOG410905X membrane-flanked domain protein BA_1065 ENOG410905X membrane-flanked domain protein BA_1066 ENOG4105CKV Membrane BA_1068 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BA_1069 ENOG4105BZ4 penicillin-binding protein BA_1070 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BA_1072 ENOG4105C1Q protoporphyrinogen oxidase BA_1078 ENOG4105NA0 Transcriptional regulator BA_1081 ENOG4105ECB domain protein BA_1087 ENOG4106AXD BA_1088 ENOG4108RQ5 Beta-lactamase domain-containing protein BA_1089 ENOG4105DF9 Lipoate-protein, ligase BA_1091 ENOG4105CEY Amp-dependent synthetase and ligase BA_1098 ENOG4105CNA YD repeat protein BA_1109 ENOG4105ENX hydrolase BA_1111 ENOG4107TVP HD domain protein BA_1113 ENOG4108AEY RNA polymerase sigma factor BA_1114 ENOG41086D8 Transcriptional regulator BA_1119 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BA_1124 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BA_1125 ENOG4105C8Q Methyl-accepting chemotaxis BA_1130 ENOG4105ZU5 s-layer protein BA_1131 ENOG4107QP3 malate synthase g BA_1135 ENOG4105VEQ Cold shock protein BA_1138 ENOG4105XVF Competence transcription factor BA_1141 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BA_1142 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BA_1152 ENOG4105ERH Fumarylacetoacetate hydrolase BA_1157 ENOG4105CAQ asparagine synthetase BA_1158 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BA_1159 ENOG4105CH6 catalase BA_1167 ENOG4105QNR S1 RNA binding domain protein BA_1169 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BA_1171 ENOG4107AYK membrAne BA_1172 ENOG41073B9 BA_1174 ENOG4108KP7 hydrolase BA_1177 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BA_1184 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BA_1185 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BA_1188 ENOG4105C31 Tryptophanyl-tRNA synthetase BA_1192 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BA_1193 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BA_1195 ENOG4108JQ7 (ABC) transporter BA_1196 ENOG4105UQX Mate efflux family protein BA_1201 ENOG4108ZCF integral membrane protein BA_1204 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BA_1206 ENOG4105DPN Oligoendopeptidase f BA_1209 ENOG4108Z18 K06886 hemoglobin BA_1210 ENOG4105MIX Adenylate cyclase BA_1213 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BA_1214 ENOG4105EMS pseudouridine synthase BA_1219 ENOG4105K64 Glycosyl transferase, family 2 BA_1224 ENOG4107TVC Glycosyl transferase, family 2 BA_1228 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BA_1229 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BA_1231 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BA_1241 ENOG4108WVJ 2'-5' rna ligase BA_1246 ENOG4105CK7 Sodium proline symporter BA_1248 ENOG4105CRQ synthase (Component I) BA_1249 ENOG4105DDQ anthranilate synthase BA_1269 ENOG4105C7S Dehydrogenase BA_1271 ENOG4105VZ8 Transcriptional regulator BA_1282 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BA_1286 ENOG4105DZ1 carboxypeptidase BA_1287 ENOG4105VFR signal peptidase BA_1296 ENOG4105C26 Dehydrogenase BA_1297 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BA_1298 ENOG4105F38 ABC transporter, permease BA_1299 ENOG4105D38 putrescine abc transporter BA_1300 ENOG4107RUE extracellular solute-binding protein family 1 BA_1302 ENOG4105EYF MMPL domain protein BA_1304 ENOG4108YBP pseudouridine synthase BA_1306 ENOG4105K4I Scp-like extracellular BA_1308 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BA_1309 ENOG4105CQB FAD linked oxidase domain protein BA_1312 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA_1313 ENOG4105BZU Histidine kinase BA_1314 ENOG4105JXH GntR family transcriptional regulator BA_1318 ENOG4106A3R peptidase BA_1321 ENOG4108QTI )-transporter BA_1322 ENOG4107TS3 membrane protein, TerC BA_1323 ENOG4105CZN Potassium uptake protein BA_1324 ENOG410681C small acid-soluble spore protein BA_1326 ENOG4108Z7G MaoC domain protein dehydratase BA_1330 ENOG4105CHR reductase BA_1332 ENOG4105MWK D-amino acid dehydrogenase, small subunit BA_1337 ENOG4105C4Y ABC transporter BA_1339 ENOG4107RCV ABC transporter, permease BA_1340 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BA_1343 ENOG4105E98 transcriptional regulator DeoR family BA_1349 ENOG4105PXI polysaccharide deacetylase BA_1351 ENOG4105BZU Histidine kinase BA_1352 ENOG41090MY MarR family Transcriptional regulator BA_1354 ENOG4106DF1 BA_1356 ENOG4105BZU Histidine kinase BA_1360 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BA_1361 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BA_1369 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BA_1372 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BA_1373 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BA_1374 ENOG4105CZV ABC transporter BA_1376 ENOG4105CJ1 ABC, transporter BA_1384 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BA_1385 ENOG4105EA8 2-Nitropropane dioxygenase BA_1386 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BA_1388 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BA_1394 ENOG4105NQC Flavodoxin BA_1402 ENOG4107QMU Mate efflux family protein BA_1403 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BA_1409 ENOG4105CZN Potassium uptake protein BA_1410 ENOG41063Y9 BA_1411 ENOG4105KBJ sporulation protein ytfj BA_1416 ENOG4105CM2 brancheD-chain amino acid aminotransferase BA_1417 ENOG4105C7K acetolactate synthase BA_1418 ENOG4108ZP8 Acetolactate synthase small subunit BA_1419 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BA_1421 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BA_1426 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BA_1432 ENOG4107RVV histidinol phosphate phosphatase, hisj family BA_1435 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BA_1436 ENOG4105E0M Sulfatase BA_1438 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BA_1442 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BA_1443 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BA_1445 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BA_1446 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BA_1447 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BA_1448 ENOG4105C8J )-transporter BA_1452 ENOG4105DFD Na H antiporter BA_1456 ENOG4105ENE Histidine kinase BA_1457 ENOG4105WH1 Two component transcriptional regulator luxr family BA_1462 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BA_1467 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BA_1471 ENOG4105CJ3 phosphate transporter BA_1472 ENOG4107GRR phosphate transport regulator BA_1474 ENOG4105BZ4 penicillin-binding protein BA_1479 ENOG4105I3N Conserved Protein BA_1482 ENOG4105BZU Histidine kinase BA_1489 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BA_1490 ENOG4105DZ1 carboxypeptidase BA_1491 ENOG4108JIC nucleoside recognition domain protein BA_1493 ENOG4105FE9 pseudouridine synthase BA_1495 ENOG4107TWT Cytochrome c biogenesis protein BA_1496 ENOG4105CRE cytochrome C BA_1497 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA_1498 ENOG4105BZU Histidine kinase BA_1499 ENOG4108WBT adenosyltransferase BA_1502 ENOG4108SAX Membrane BA_1504 ENOG4105T7X BA_1505 ENOG4105C9U ATP-dependent DNA helicase RecQ BA_1506 ENOG4105I7S Abortive infection protein BA_1509 ENOG4107X2D transcriptional regulator, merr family BA_1510 ENOG4108S6Z Negative regulator of genetic competence BA_1515 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BA_1516 ENOG4105HDK L-asparaginase BA_1523 ENOG4105S2F BA_1524 ENOG41065D1 BA_1530 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BA_1533 ENOG4105XXQ heptaprenyl diphosphate synthase component I BA_1535 ENOG4105EAH synthase BA_1539 ENOG4105CIH Imidazole acetol-phosphate transaminase BA_1541 ENOG41068YB TPR repeat-containing protein BA_1544 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BA_1545 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BA_1546 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BA_1553 ENOG4108JYZ YitT family BA_1554 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BA_1557 ENOG4105FJR Lmbe family BA_1558 ENOG4105CPK Glycosyl transferase (Group 1 BA_1565 ENOG4105DVT helicase BA_1566 ENOG4105YAC BA_1570 ENOG4105CSM endonuclease III BA_1572 ENOG4105BZ4 penicillin-binding protein BA_1584 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BA_1586 ENOG4105DVT helicase BA_1587 ENOG4105CTD carboxy-peptidase BA_1590 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BA_1592 ENOG4105C2W permease BA_1593 ENOG4105DHF Membrane BA_1595 ENOG410890F Dynamin family BA_1597 ENOG4108W0I acetyltransferase BA_1599 ENOG4105KHC sulfurtransferase BA_1602 ENOG4106032 Glutathionylspermidine synthase BA_1619 ENOG4108SZE gCN5-related N-acetyltransferase BA_1623 ENOG41081VK Ribonuclease BA_1636 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BA_1639 ENOG4107RWR Sodium hydrogen exchanger BA_1640 ENOG4105CN5 Metallo-Beta-Lactamase BA_1641 ENOG4108Z5V transcriptional regulator, merr family BA_1643 ENOG4105H67 Protein of unknown function (DUF421) BA_1645 ENOG41080C8 DUF218 domain BA_1656 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BA_1658 ENOG4107R0U MotA TolQ exbB proton channel BA_1659 ENOG4105ER2 Ompa motb domain protein BA_1660 ENOG4107YTP response regulator receiver protein BA_1662 ENOG4105DD5 Flagellar motor switch protein BA_1665 ENOG4105BZU Histidine kinase BA_1669 ENOG4105E1Q flagellar hook-associated protein BA_1674 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BA_1675 ENOG4108ZC9 flagellar basal-body rod protein flgc BA_1676 ENOG41075Z6 flagellar hook-basal body complex protein fliE BA_1679 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BA_1686 ENOG4105BZE flagellar hook protein, FlgE BA_1693 ENOG4105K64 Glycosyl transferase, family 2 BA_1706 ENOG4105I03 Flagellin BA_1707 ENOG4105E4C Lytic transglycosylase catalytic BA_1710 ENOG4105DD5 Flagellar motor switch protein BA_1712 ENOG4105CN7 Flagellar biosynthetic protein FliP BA_1713 ENOG4105VS8 Flagellar biosynthetic protein fliq BA_1715 ENOG4105D00 flagellar biosynthetic protein flhB BA_1716 ENOG4105D7B Flagellar biosynthesis protein flha BA_1718 ENOG4105FZW flagellar biosynthesis regulator FlhF BA_1719 ENOG4105KTQ flagellar basal-body rod protein BA_1720 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BA_1725 ENOG4108RZE Tetr family transcriptional regulator BA_1728 ENOG4105KAC Antibiotic biosynthesis monooxygenase BA_1733 ENOG4105DUM transcriptional regulator, lysR family BA_1734 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BA_1735 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BA_1736 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BA_1737 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BA_1745 ENOG4105CVJ phosphoglycerate mutase BA_1751 ENOG4105CAQ asparagine synthetase BA_1756 ENOG4105PGM cation diffusion facilitator family transporter BA_1758 ENOG4105DRR Transcriptional regulator, GntR family BA_1759 ENOG4108UZ3 Transporter BA_1760 ENOG4105CKI cobalamin synthesis protein BA_1762 ENOG4108PJD permease BA_1766 ENOG4105DFD Na H antiporter BA_1767 ENOG4105C9Q fumarate hydratase class II BA_1774 ENOG4105EC3 peptidase S51, dipeptidase E BA_1778 ENOG4107QIV Cytochrome c biogenesis protein BA_1785 ENOG4106BRA Membrane BA_1793 ENOG4105CJ1 ABC, transporter BA_1797 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BA_1800 ENOG4108IJ0 Aspartate ammonia-lyase BA_1801 ENOG4105C6K Malic enzyme BA_1815 ENOG4105FVX BA_1823 ENOG4105CSR polyphosphate kinase 2 BA_1828 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BA_1830 ENOG4105EU0 Major facilitator Superfamily BA_1831 ENOG4105C6T cysteine synthase BA_1835 ENOG4105C8J )-transporter BA_1837 ENOG4105X5K response regulator receiver protein BA_1838 ENOG4105H67 Protein of unknown function (DUF421) BA_1842 ENOG4106KE4 Dehydrogenase BA_1846 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BA_1847 ENOG4105CHR reductase BA_1849 ENOG4105CM2 brancheD-chain amino acid aminotransferase BA_1850 ENOG4105C7K acetolactate synthase BA_1852 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BA_1854 ENOG4105C7B Threonine dehydratase BA_1858 ENOG4105C6X Major Facilitator BA_1859 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BA_1861 ENOG4105DY9 regulatoR BA_1862 ENOG4105CYC Transferase BA_1866 ENOG4105F6J Alpha beta hydrolase fold BA_1876 ENOG41068WN BA_1880 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BA_1881 ENOG4105C72 UPF0176 protein BA_1884 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BA_1891 ENOG4107RHR regulatoR BA_1893 ENOG4105D9N nucleoside BA_1894 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BA_1901 ENOG4107RAQ aminopeptidase BA_1902 ENOG4107STQ Multicopper oxidase BA_1912 ENOG4108T5E Copper resistance protein BA_1913 ENOG4105KTB nuclear export factor GLE1 BA_1915 ENOG4107RT3 EamA-like transporter family BA_1916 ENOG4105GZI Transcriptional regulator BA_1917 ENOG4108Z40 Transcriptional regulator BA_1918 ENOG4107ZXU DSBA oxidoreductase BA_1919 ENOG4108TVJ Nitroreductase BA_1921 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BA_1922 ENOG4106F5Q Membrane BA_1923 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BA_1925 ENOG4105CKI cobalamin synthesis protein BA_1929 ENOG4108Z7G MaoC domain protein dehydratase BA_1930 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BA_1933 ENOG4105C0Z ABC transporter BA_1934 ENOG4108IV0 ABC, transporter BA_1935 ENOG4105C32 Amino acid ABC transporter (Permease) BA_1937 ENOG4105SKE transcriptional Regulator LysR family BA_1941 ENOG4105YGB Transcriptional regulator BA_1943 ENOG4105C4M (Ubiquinol oxidase) subunit I BA_1944 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BA_1945 ENOG4108JJ9 ABC, transporter BA_1946 ENOG4108JJ8 (ABC) transporter BA_1955 ENOG4105EFI regulatoR BA_1956 ENOG4105BZU Histidine kinase BA_1960 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BA_1961 ENOG4108ZJ4 polysaccharide deacetylase BA_1968 ENOG4105D6E homoserine dehydrogenase BA_1973 ENOG4108KGH TRANSCRIPTIONal BA_1975 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BA_1976 ENOG4105BZU Histidine kinase BA_1977 ENOG4107VMI polysaccharide deacetylase BA_1979 ENOG4105KT7 mgtC SapB transporter BA_1980 ENOG4105VRR gCN5-related N-acetyltransferase BA_1982 ENOG4105DUU IucA IucC family protein BA_1983 ENOG4105CEY Amp-dependent synthetase and ligase BA_1986 ENOG4108WBH protein TIM barrel BA_1987 ENOG4105YWU small acid-soluble spore protein BA_1989 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BA_2000 ENOG4105KRN Transcriptional regulator, abrb family BA_2002 ENOG4105YVS arsR family transcriptional regulator BA_2003 ENOG4107SET aldo keto reductase BA_2004 ENOG4107XZQ multidrug resistance protein BA_2009 ENOG4105C8Q Methyl-accepting chemotaxis BA_2012 ENOG4108K88 Membrane BA_2013 ENOG4108WPJ Ferritin-like domain BA_2016 ENOG4105DEN Luciferase family BA_2020 ENOG4107QM2 Aldo Keto reductase BA_2021 ENOG4105CKI cobalamin synthesis protein BA_2035 ENOG4105DSE periplasmic solute binding protein BA_2037 ENOG4105K4T epimerase BA_2039 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BA_2044 ENOG4105CVJ phosphoglycerate mutase BA_2048 ENOG4107T5V SNARE associated Golgi BA_2051 ENOG4108PJD permease BA_2053 ENOG4108S4H thioesterase Superfamily protein BA_2054 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BA_2058 ENOG4105SXS Protein of unknown function (DUF456) BA_2059 ENOG4105C37 (CBS) domain BA_2064 ENOG4108Z7R Chaperone CsaA BA_2068 ENOG4108ZRV stage ii sporulation protein p BA_2070 ENOG4108VXD carboxy-peptidase BA_2072 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BA_2077 ENOG4108X4Q Hydrolase BA_2079 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BA_2080 ENOG4107RBS Methyltransferase BA_2083 ENOG41087PP glycosyltransferase MGT family BA_2084 ENOG4108JYZ YitT family BA_2085 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BA_2091 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BA_2101 ENOG4105KBJ sporulation protein ytfj BA_2106 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BA_2110 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BA_2111 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BA_2113 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BA_2114 ENOG4105EMN RNA polymerase sigma factor BA_2119 ENOG4108V06 Glutathione peroxidase BA_2122 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BA_2126 ENOG4108IUE nitrate reductase beta subunit BA_2127 ENOG4105R3A Nitrate reductase BA_2132 ENOG4107V6Q Cyclic nucleotide-binding domain BA_2133 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BA_2134 ENOG4105D06 uba thif-type nad fad binding protein BA_2135 ENOG4105CVM Molybdenum cofactor synthesis domain protein BA_2136 ENOG4108ZAF Molybdopterin BA_2142 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BA_2143 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BA_2144 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BA_2145 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BA_2146 ENOG4108IFG nitrite reductase, (NAD(P)H) BA_2147 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BA_2154 ENOG4105MCT stage V sporulation protein S BA_2159 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BA_2164 ENOG4105C5H ABC transporter BA_2168 ENOG4108UUM single-stranded DNA-binding protein BA_2174 ENOG4107YX5 Pfam:DUF548 BA_2175 ENOG4105C75 arginyL-tRNA synthetase BA_2181 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BA_2186 ENOG4105C5S asparaginyl-tRNA synthetase BA_2190 ENOG4105EC2 ftsk spoIIIe BA_2210 ENOG4105BZW Glycerate kinase BA_2211 ENOG4107QPK )-transporter BA_2212 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA_2213 ENOG41062D9 Histidine kinase BA_2216 ENOG4105C8J )-transporter BA_2220 ENOG4107XGZ Hydrolase BA_2221 ENOG4105CY2 Citrate transporter BA_2222 ENOG4105C0A alcohol dehydrogenase BA_2225 ENOG4105KD7 acetyltransferase BA_2231 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BA_2235 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BA_2238 ENOG4107RVG penicillin-binding protein BA_2239 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BA_2240 ENOG4105E9Q Acyl-transferase BA_2241 ENOG4108UT2 hemolysin iii BA_2243 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BA_2246 ENOG4108RCR degv family BA_2247 ENOG4105E8R UPF0173 metal-dependent hydrolase BA_2249 ENOG4108KF3 Electron transport protein SCO1 SenC BA_2250 ENOG4107Y70 Heat shock protein BA_2251 ENOG4105CAQ asparagine synthetase BA_2255 ENOG4108MES Periplasmic binding protein BA_2256 ENOG4105F0I Aminotransferase BA_2263 ENOG4105D8X mechanosensitive ion channel BA_2264 ENOG4105BZU Histidine kinase BA_2265 ENOG4105WH1 Two component transcriptional regulator luxr family BA_2279 ENOG4108IJ8 ABC transporter BA_2280 ENOG4105E90 ABC transporter BA_2288 ENOG4105C37 (CBS) domain BA_2294 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BA_2297 ENOG4107S4Y M20 DapE family protein YgeY BA_2298 ENOG4108TSC N-acetyltransferase BA_2299 ENOG4108JUB Transcriptional regulator BA_2300 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BA_2308 ENOG4108N23 SpoOM-related protein BA_2309 ENOG410841Q phosphoesterase PA-phosphatase related protein BA_2311 ENOG4105SZ6 Thioredoxin BA_2314 ENOG4108IBT Inherit from COG: transposase BA_2336 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BA_2345 ENOG4105BZ4 penicillin-binding protein BA_2346 ENOG4105CZM Major Facilitator BA_2347 ENOG4105W8X HesB YadR YfhF-family protein BA_2349 ENOG4105DXD 2-methylcitrate dehydratase BA_2350 ENOG4105CR4 methylisocitrate lyase BA_2352 ENOG4105C1G acyl-Coa dehydrogenase BA_2353 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BA_2355 ENOG4105N14 lysine exporter protein LysE YggA BA_2356 ENOG4105E39 Enoyl-CoA hydratase BA_2359 ENOG4107RFY SbcCD D subunit BA_2360 ENOG4105EYH Exonuclease BA_2367 ENOG4105FCD Major Facilitator BA_2368 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BA_2369 ENOG4105E4F Isochorismate synthase BA_2370 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BA_2371 ENOG4105WQI isochorismatase BA_2372 ENOG4105CEY Amp-dependent synthetase and ligase BA_2373 ENOG4105WQT MbtH domain protein BA_2374 ENOG4105C0R drug resistance transporter emrb qaca subfamily BA_2377 ENOG4105K70 DNA-binding protein BA_2381 ENOG4105BZG amino acid carrier protein BA_2386 ENOG4105FE9 pseudouridine synthase BA_2388 ENOG4105C22 threonyL-tRNA synthetase BA_2392 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BA_2396 ENOG4108D32 Methyltransferase BA_2402 ENOG41081I9 integral membrane protein BA_2405 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BA_2407 ENOG4105EYF MMPL domain protein BA_2412 ENOG4105WCN acetyltransferase BA_2418 ENOG4105C1Q protoporphyrinogen oxidase BA_2420 ENOG41068WN BA_2422 ENOG4105VEQ Cold shock protein BA_2426 ENOG410667J hydrolase BA_2435 ENOG4107V2S Transcriptional regulator BA_2436 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BA_2439 ENOG4105DND Transcriptional regulator BA_2440 ENOG4108RPX mosc domain containing protein BA_2443 ENOG4105BZ1 (ABC) transporter BA_2444 ENOG4105BZ1 (ABC) transporter BA_2448 ENOG4108JCI Transcriptional regulator BA_2454 ENOG4108KPJ rna polymerase sigma factor BA_2460 ENOG4105F32 YngK protein BA_2466 ENOG4105RD7 BadF BadG BcrA BcrD BA_2468 ENOG4107STF Involved in phosphonate degradation (By similarity) BA_2472 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BA_2475 ENOG4105C1J atp-dependent rna helicase BA_2479 ENOG4108RZE Tetr family transcriptional regulator BA_2483 ENOG41088CC tellurite resistance protein tehB BA_2485 ENOG4108I0C methyltransferase BA_2486 ENOG4107RA9 decarboxylase BA_2487 ENOG41090HR transcriptional regulator BA_2498 ENOG4105CIN aminoacyl-histidine dipeptidase BA_2504 ENOG4107RF6 penicillin-binding protein BA_2508 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BA_2509 ENOG4105ETE Transcriptional regulator (LacI family BA_2510 ENOG4105IE8 Alpha-ketoglutarate permease BA_2511 ENOG4105CK5 oxidoreductase BA_2516 ENOG4105D2N Aldolase BA_2517 ENOG4105DH8 myo-inositol catabolism BA_2523 ENOG4105VZ8 Transcriptional regulator BA_2526 ENOG4108VXD carboxy-peptidase BA_2530 ENOG41067SE Tetr family transcriptional regulator BA_2531 ENOG4105C5H ABC transporter BA_2533 ENOG4105BZU Histidine kinase BA_2536 ENOG4106ANW SMI1_KNR4 BA_2537 ENOG4105CEP NADH dehydrogenase BA_2538 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BA_2541 ENOG4105CJ1 ABC, transporter BA_2543 ENOG4107Z3H Transcriptional regulator, TetR family BA_2547 ENOG4105C1G acyl-Coa dehydrogenase BA_2548 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BA_2549 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BA_2550 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BA_2551 ENOG4105E39 Enoyl-CoA hydratase BA_2552 ENOG4107QX3 carboxylase BA_2553 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BA_2555 ENOG4105WCN acetyltransferase BA_2556 ENOG4105DBI uridine monophosphokinase BA_2559 ENOG4105DZ1 carboxypeptidase BA_2562 ENOG4105T9C HD domain BA_2564 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BA_2572 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BA_2572 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BA_2575 ENOG4105FQP Beta-lactamase BA_2577 ENOG4107Y80 Major Facilitator superfamily BA_2581 ENOG4105CUV Homoserine Kinase BA_2588 ENOG4105CPQ Dehydrogenase BA_2611 ENOG4105ETU transcriptional activator (TenA BA_2634 ENOG410667J hydrolase BA_2636 ENOG4105BZU Histidine kinase BA_2637 ENOG4107RF6 penicillin-binding protein BA_2641 ENOG4108JJB ABC transporter BA_2644 ENOG4108HGU Histidine kinase BA_2647 ENOG4105CB2 alcohol dehydrogenase BA_2648 ENOG4105CJN penicillin-binding protein BA_2650 ENOG4105FQP Beta-lactamase BA_2657 ENOG4108V4B ThiJ pfpI BA_2664 ENOG4107Y80 Major Facilitator superfamily BA_2668 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BA_2672 ENOG4107Y9U Membrane BA_2680 ENOG4105FCD Major Facilitator BA_2683 ENOG4105E09 nadh pyrophosphatase BA_2684 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BA_2685 ENOG4108Z4K mutator MutT protein BA_2692 ENOG4108XI2 Domain of unknown function (DUF1963) BA_2698 ENOG4105KWG Pfam:DUF1696 BA_2705 ENOG4105PKS Excinuclease abc c subunit domain protein BA_2715 ENOG4107VFR oxidoreductase BA_2720 ENOG4105PAD Hydrolase BA_2724 ENOG4105DY8 decarboxylase BA_2728 ENOG4108IUM Glycogen debranching enzyme BA_2734 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BA_2736 ENOG4105FDR Membrane BA_2743 ENOG4108V3A UPF0421 protein BA_2747 ENOG4105MSI germination protein ypeb BA_2751 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BA_2752 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BA_2753 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BA_2754 ENOG4107Z3H Transcriptional regulator, TetR family BA_2761 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BA_2765 ENOG4105E98 transcriptional regulator DeoR family BA_2769 ENOG41062ES Transcriptional regulator BA_2774 ENOG4107QKR Dehydrogenase BA_2776 ENOG4107RUY (E1 component), alpha subunit BA_2778 ENOG4105E1F short-chain dehydrogenase reductase BA_2779 ENOG4105RHY Pfam:UPF0157 BA_2785 ENOG4107SQ8 Glycine betaine BA_2786 ENOG4108IJ7 Glycine betaine BA_2791 ENOG4105E66 phosphoriboisomerase A BA_2792 ENOG41082BV acetyltransferase BA_2793 ENOG4108M1A Chitin-binding protein BA_2803 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BA_2814 ENOG4105EEM helicase BA_2818 ENOG4105C9U ATP-dependent DNA helicase RecQ BA_2827 ENOG4108M1A Chitin-binding protein BA_2830 ENOG4105BZG amino acid carrier protein BA_2831 ENOG4105C26 Dehydrogenase BA_2832 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BA_2833 ENOG4105CTU Proline racemase BA_2834 ENOG4105CTU Proline racemase BA_2835 ENOG41080HI glycine oxidase BA_2842 ENOG4107T5V SNARE associated Golgi BA_2846 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BA_2847 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BA_2850 ENOG4105DTQ mandelate racemase muconate lactonizing BA_2860 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BA_2861 ENOG4105BZU Histidine kinase BA_2869 ENOG4105DPN Oligoendopeptidase f BA_2872 ENOG4105EPR degv family BA_2881 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BA_2882 ENOG4106K7D Major facilitator family transporter BA_2887 ENOG4107BMA Transglycosylase associated protein BA_2890 ENOG41089UC methyltransferase, type 11 BA_2899 ENOG4105CHM Aminotransferase BA_2906 ENOG4105DVE abc transporter atp-binding protein BA_2916 ENOG4105C02 permease BA_2919 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BA_2920 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BA_2921 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BA_2926 ENOG4105E09 nadh pyrophosphatase BA_2930 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BA_2941 ENOG4107VC0 DNA alkylation repair enzyme BA_2944 ENOG4107VMI polysaccharide deacetylase BA_2946 ENOG4108ZCF integral membrane protein BA_2947 ENOG4105E0M Sulfatase BA_2948 ENOG4105C5H ABC transporter BA_2951 ENOG41082JN Transcriptional regulator BA_2955 ENOG4105CIH Imidazole acetol-phosphate transaminase BA_2956 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BA_2958 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BA_2967 ENOG41069ER domain protein BA_2970 ENOG4105EMN RNA polymerase sigma factor BA_2975 ENOG4105D4B ABC, transporter BA_2977 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BA_2979 ENOG4105DKT Transcriptional regulator BA_2982 ENOG41061GT Aldolase BA_2987 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BA_2993 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BA_2995 ENOG4105II7 pyrroline-5-carboxylate reductase BA_2997 ENOG4107258 Transcriptional regulator BA_2999 ENOG4105E0Y RtcB Protein BA_3000 ENOG4105ECK Fatty Acid Desaturase BA_3001 ENOG4105G6Z alkaline phosphatase BA_3003 ENOG4105VMP Transcriptional regulator BA_3006 ENOG41090T1 Membrane BA_3008 ENOG4108WCX response regulator BA_3010 ENOG41068WN BA_3016 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BA_3022 ENOG4105CKK Glycosyl transferase, family 2 BA_3026 ENOG4105CKK Glycosyl transferase, family 2 BA_3029 ENOG4105C8Y Acetylornithine aminotransferase BA_3038 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BA_3040 ENOG4108TVJ Nitroreductase BA_3041 ENOG4105FS7 Transcriptional regulator BA_3049 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BA_3052 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BA_3058 ENOG4108XET gCN5-related N-acetyltransferase BA_3074 ENOG410635A Membrane BA_3075 ENOG4105KNA -acetyltransferase BA_3076 ENOG4108IQI permease BA_3078 ENOG4105F1N DNA alkylation repair BA_3089 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BA_3097 ENOG4105P4J Allophanate hydrolase, subunit 1 BA_3098 ENOG4107258 Transcriptional regulator BA_3100 ENOG4106N3A copper homeostasis protein cutc BA_3102 ENOG4108ZRV stage ii sporulation protein p BA_3103 ENOG4108ZHR arsR family transcriptional regulator BA_3105 ENOG4105FDT acyl-CoA dehydrogenase BA_3110 ENOG4105DWD nucleoside recognition domain protein BA_3116 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BA_3131 ENOG4105E2A Dehydrogenase BA_3136 ENOG4108IJ0 Aspartate ammonia-lyase BA_3137 ENOG4105HDK L-asparaginase BA_3138 ENOG4108IMY Transcriptional regulator BA_3140 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BA_3141 ENOG4105CUB amino acid BA_3143 ENOG4105II7 pyrroline-5-carboxylate reductase BA_3145 ENOG4105C6K Malic enzyme BA_3155 ENOG4105CSV Glutaminase BA_3162 ENOG4105CGH 5'-nucleotidase BA_3164 ENOG4105CH6 catalase BA_3166 ENOG4105CHJ isochorismatase hydrolase BA_3172 ENOG41090MY MarR family Transcriptional regulator BA_3179 ENOG4108606 TspO/MBR family BA_3180 ENOG4105CVP deoxyribo-dipyrimidine photolyase BA_3183 ENOG4108TWJ NADH dehydrogenase subunit 5 BA_3184 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BA_3186 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BA_3187 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BA_3189 ENOG4105DSE periplasmic solute binding protein BA_3190 ENOG4105CC5 ABC transporter BA_3191 ENOG4105DIK (ABC) transporter BA_3197 ENOG4105D6J arsenicaL-resistance protein BA_3198 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BA_3199 ENOG41085FC arsR family transcriptional regulator BA_3202 ENOG4105F7F Chaperone BA_3204 ENOG4105CHR reductase BA_3205 ENOG4108YXU transcriptional regulator AsnC family BA_3221 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BA_3223 ENOG4105C0R drug resistance transporter emrb qaca subfamily BA_3226 ENOG4105IIP Membrane BA_3229 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA_3230 ENOG41062D9 Histidine kinase BA_3236 ENOG4105K6H D-cysteine desulfhydrase BA_3243 ENOG4105VZ8 Transcriptional regulator BA_3247 ENOG4108NNI Beta-lactamase domain-containing protein BA_3248 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BA_3251 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BA_3252 ENOG4105JQZ Methyltransferase BA_3255 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BA_3256 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BA_3260 ENOG4105BZU Histidine kinase BA_3263 ENOG4108U05 Transcriptional regulator BA_3266 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BA_3267 ENOG4105DJB Major Facilitator Superfamily BA_3268 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BA_3269 ENOG4107QR9 Iron-sulfur cluster binding protein BA_3271 ENOG4106P55 Transcriptional regulator BA_3275 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BA_3281 ENOG4105TRI Hydrolase BA_3288 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BA_3296 ENOG4107QJQ Mate efflux family protein BA_3302 ENOG4105EQ0 Major Facilitator superfamily BA_3303 ENOG4108JGH Tetr family transcriptional regulator BA_3306 ENOG4105C44 Serine transporter BA_3307 ENOG4105EJQ L-serine dehydratase BA_3312 ENOG4108JPW Aminotransferase BA_3315 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BA_3317 ENOG4105DVH amino acid BA_3320 ENOG4108JQ1 Dehydrogenase BA_3324 ENOG4108AEY RNA polymerase sigma factor BA_3327 ENOG41082W1 Cupin 2, conserved barrel domain protein BA_3328 ENOG410874W AraC family transcriptional regulator BA_3332 ENOG4105HIR S-layer domain protein BA_3342 ENOG4108ISG Major Facilitator BA_3344 ENOG4107MII Sugar-specific transcriptional regulator TrmB BA_3345 ENOG4105CZM Major Facilitator BA_3349 ENOG4105DA5 (ABC) transporter BA_3350 ENOG41069JR BA_3352 ENOG4105RXJ BA_3353 ENOG4105KPY Small multidrug resistance protein BA_3354 ENOG4105KBX Transcriptional regulator, TetR family BA_3356 ENOG4105CRW Short chain fatty acid transporter BA_3358 ENOG4105DYS nad(p)h dehydrogenase (quinone) BA_3364 ENOG4108JJB ABC transporter BA_3365 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BA_3370 ENOG4108K8S endonuclease I BA_3373 ENOG41067QW Transcriptional regulator BA_3375 ENOG4108Z66 YbaK ebsC protein BA_3376 ENOG4105CUT histidyl-tRNA synthetase BA_3379 ENOG4105KVH Transcriptional regulator BA_3380 ENOG4108RCM Nitroreductase BA_3385 ENOG4108PSK reductase BA_3387 ENOG4105CJ1 ABC, transporter BA_3399 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BA_3400 ENOG4105DKQ ROK family BA_3401 ENOG4106UW1 Major Facilitator superfamily BA_3402 ENOG4108UW5 maltose o-acetyltransferase BA_3406 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BA_3408 ENOG4105C31 Tryptophanyl-tRNA synthetase BA_3409 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BA_3414 ENOG4105DMQ Methyltransferase BA_3416 ENOG4105EV4 Multidrug resistance protein mdtH BA_3422 ENOG4105C37 (CBS) domain BA_3425 ENOG4105DDN Pentapeptide repeat-containing protein BA_3426 ENOG4105XDF Protein of unknown function (DUF1272) BA_3427 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BA_3428 ENOG4105CMG Carbohydrate kinase BA_3429 ENOG4105C6Z Gluconate BA_3430 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BA_3433 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BA_3434 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BA_3435 ENOG4105CIS alcohol dehydrogenase BA_3436 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BA_3440 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BA_3442 ENOG4105D4Y metalloprotease BA_3446 ENOG4105CV8 reductase BA_3447 ENOG4105F27 Major Facilitator BA_3450 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BA_3451 ENOG4105C44 Serine transporter BA_3457 ENOG4105KVH Transcriptional regulator BA_3458 ENOG4108TZY GntR Family Transcriptional Regulator BA_3460 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BA_3461 ENOG4105KVH Transcriptional regulator BA_3462 ENOG4105KVH Transcriptional regulator BA_3469 ENOG4105JAB phenazine biosynthesis protein, phzf family BA_3471 ENOG4105CHR reductase BA_3475 ENOG4105KVH Transcriptional regulator BA_3480 ENOG4108ZJ4 polysaccharide deacetylase BA_3491 ENOG4105KAF membrAne BA_3497 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BA_3501 ENOG4107YXZ hydrolase, family 25 BA_3506 ENOG4105ED2 Beta-lactamase BA_3508 ENOG4105H3G oxidoreductase BA_3524 ENOG4108TN2 lmbE family BA_3526 ENOG4107R3E Citrate transporter BA_3531 ENOG4108MES Periplasmic binding protein BA_3533 ENOG4105EHG Permease protein BA_3534 ENOG4105DQ5 transport system permease protein BA_3535 ENOG4105NX3 Membrane BA_3536 ENOG4107ZY0 Phenazine biosynthesis-like protein BA_3540 ENOG4107CUJ Protein of unknown function (DUF2690) BA_3543 ENOG4107V2S Transcriptional regulator BA_3547 ENOG4105C98 muts2 protein BA_3551 ENOG4105E5K Alpha-amylase BA_3553 ENOG4105DPN Oligoendopeptidase f BA_3554 ENOG4108A04 Beta-lactamase BA_3560 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BA_3565 ENOG41082BM Transcriptional regulator, arsr family BA_3566 ENOG4105CIS alcohol dehydrogenase BA_3572 ENOG4105RHY Pfam:UPF0157 BA_3574 ENOG4105C09 Bile acid BA_3575 ENOG4105CQB FAD linked oxidase domain protein BA_3580 ENOG4108UT6 Transferase hexapeptide repeat containing protein BA_3582 ENOG4105K64 Glycosyl transferase, family 2 BA_3583 ENOG4105E39 Enoyl-CoA hydratase BA_3585 ENOG4105KT7 mgtC SapB transporter BA_3587 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BA_3588 ENOG41073R8 VanW family BA_3590 ENOG4108R1P BA_3594 ENOG4105VEQ Cold shock protein BA_3598 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BA_3602 ENOG410904N short-chain dehydrogenase reductase BA_3604 ENOG4106IQC argininosuccinate lyase BA_3607 ENOG4108IA2 Sodium pantothenate symporter BA_3609 ENOG4105C26 Dehydrogenase BA_3610 ENOG4105CHR reductase BA_3612 ENOG4105EWU Squalene--hopene cyclase BA_3614 ENOG4105FR1 rard protein BA_3615 ENOG410696E Membrane BA_3620 ENOG4105D1F ATP-binding protein BA_3622 ENOG4108ZAF Molybdopterin BA_3623 ENOG4105CVM Molybdenum cofactor synthesis domain protein BA_3624 ENOG4105D06 uba thif-type nad fad binding protein BA_3625 ENOG4105TMB Formate nitrite transporter BA_3628 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BA_3629 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BA_3631 ENOG4108JB9 formate dehydrogenase BA_3633 ENOG4105E1K spore germination protein BA_3647 ENOG4108KGH TRANSCRIPTIONal BA_3649 ENOG4105EMN RNA polymerase sigma factor BA_3653 ENOG4105CIG ABC transporter BA_3655 ENOG4105D9R oxidoreductase BA_3657 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BA_3659 ENOG4105K4P CoA-binding domain protein BA_3660 ENOG4105C0H protease BA_3661 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA_3663 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BA_3665 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BA_3666 ENOG4105W8X HesB YadR YfhF-family protein BA_3672 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BA_3674 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BA_3676 ENOG4108JJA ABC, transporter BA_3677 ENOG4108I0Z Aconitate hydratase BA_3682 ENOG4105E5W Transporter BA_3684 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BA_3688 ENOG4107F3J Amp-dependent synthetase and ligase BA_3689 ENOG4107ZYJ bioY protein BA_3690 ENOG4105CEY Amp-dependent synthetase and ligase BA_3700 ENOG4107AYK membrAne BA_3702 ENOG4105BZU Histidine kinase BA_3703 ENOG4105FBA Phospholipase Carboxylesterase BA_3704 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BA_3705 ENOG4105CK7 Sodium proline symporter BA_3706 ENOG4105CBC glutamate synthase BA_3707 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BA_3708 ENOG4108VJ1 Transcriptional regulator (CarD family BA_3709 ENOG4108903 Formimidoylglutamase BA_3714 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BA_3727 ENOG4107QIV Cytochrome c biogenesis protein BA_3729 ENOG4107RSM transcriptional regulator BA_3730 ENOG4105VAW lrga family BA_3731 ENOG41067MG lrgb family BA_3737 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BA_3740 ENOG4105BZ1 (ABC) transporter BA_3741 ENOG4105BZ1 (ABC) transporter BA_3745 ENOG4105D7V transposase BA_3749 ENOG4105D5T phosphonate abc transporter BA_3753 ENOG4108SVB resolvase BA_3757 ENOG4105K7K Transcriptional regulator BA_3767 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BA_3768 ENOG4105XSJ toxin secretion phage lysis holin BA_3813 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BA_3833 ENOG4105C5F glutamine synthetase BA_3834 ENOG4105KV4 Transcriptional regulator BA_3835 ENOG4105CXI aluminum resistance protein BA_3836 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BA_3837 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BA_3838 ENOG4105EN6 Membrane BA_3839 ENOG4106F1P AAA ATPase, central domain protein BA_3845 ENOG41069ER domain protein BA_3846 ENOG4105DM4 PTS System BA_3847 ENOG4105DE4 1-phosphofructokinase BA_3848 ENOG4105E98 transcriptional regulator DeoR family BA_3850 ENOG4108SJC Membrane BA_3853 ENOG4105C85 amino acid BA_3857 ENOG4105TMB Formate nitrite transporter BA_3858 ENOG4105K70 DNA-binding protein BA_3859 ENOG4105C59 p-type ATPase BA_3860 ENOG410681U heavy metal transport detoxification protein BA_3861 ENOG4105VPX protein, conserved in bacteria BA_3863 ENOG4105NIV Esterase BA_3864 ENOG4105E0A ABC, transporter BA_3868 ENOG4105CGK Exodeoxyribonuclease III BA_3870 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BA_3871 ENOG4105D03 DNA-3-methyladenine glycosylase II BA_3878 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BA_3879 ENOG4105BZU Histidine kinase BA_3884 ENOG41067MG lrgb family BA_3887 ENOG4107TTQ Alpha beta hydrolase fold BA_3888 ENOG4107YEI lmbE family BA_3893 ENOG4105F0V Cell wall hydrolase BA_3894 ENOG4107R6R udp-galactopyranose mutase BA_3895 ENOG4105E0M Sulfatase BA_3896 ENOG410890F Dynamin family BA_3898 ENOG4107QHE Choloylglycine hydrolase BA_3903 ENOG4105DA5 (ABC) transporter BA_3908 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BA_3909 ENOG4105DQU oxidoreductase, subunit beta BA_3910 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BA_3911 ENOG4108IGT Dipeptidase BA_3912 ENOG4105MCT stage V sporulation protein S BA_3913 ENOG4105D48 metallophosphoesterase BA_3917 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BA_3920 ENOG4105XZV Protein of unknown function (DUF3243) BA_3921 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BA_3926 ENOG4108JQ9 ABC transporter BA_3927 ENOG4105DIH basic membrane BA_3928 ENOG4105FDP GntR family transcriptional regulator BA_3930 ENOG4107QZI cell division protein FtsK BA_3932 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BA_3935 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BA_3937 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BA_3938 ENOG4108S0H Dipicolinic acid synthetase, b subunit BA_3939 ENOG4105E35 Dipicolinate synthase subunit A BA_3942 ENOG4105C1V Peptidase, M16 BA_3946 ENOG4105DTN riboflavin biosynthesis protein ribF BA_3947 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BA_3949 ENOG4105W7A Protein of unknown function (DUF503) BA_3951 ENOG4105VHM ribosomal protein BA_3952 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BA_3953 ENOG4105CHV Transcription elongation factor NusA BA_3955 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BA_3958 ENOG4105DZP Membrane-associated zinc metalloprotease BA_3959 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BA_3960 ENOG4105KNE Phosphatidate cytidylyltransferase BA_3961 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BA_3969 ENOG4108HE4 integrase family BA_3971 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BA_3973 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BA_3976 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BA_3981 ENOG4105VB6 UPF0109 protein BA_3985 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BA_3986 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BA_3989 ENOG4105CHR reductase BA_3990 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BA_3993 ENOG4105CB5 ATP-dependent DNA helicase recG BA_3994 ENOG4105DP4 dak2 domain fusion protein ylov BA_3995 ENOG4108ZAA Alkaline-shock protein BA_3997 ENOG4105FJ0 thiamine BA_3998 ENOG4105DJV ribulose-phosphate 3-epimerase BA_3999 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BA_4000 ENOG4105D9P serine threonine protein kinase BA_4001 ENOG4108ZF3 Phosphatase BA_4003 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BA_4005 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BA_4006 ENOG4105C25 Primosomal protein n' BA_4007 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BA_4011 ENOG4105DSJ YicC domain protein BA_4013 ENOG4105F23 Fibronectin-binding protein BA_4014 ENOG4105DC7 peptidase M24 BA_4026 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BA_4031 ENOG4105C34 Pseudouridine synthase BA_4034 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BA_4036 ENOG4105DBK s4 domain protein BA_4037 ENOG41067XK integral membrane protein BA_4039 ENOG4105DFA alanine racemase domain protein BA_4040 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BA_4041 ENOG4105WR5 sporulation protein, YlmC YmxH family BA_4043 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA_4045 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BA_4046 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BA_4047 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BA_4048 ENOG4105D4A Cell wall formation (By similarity) BA_4049 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BA_4050 ENOG4105CNI cell division protein FtsW BA_4053 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BA_4054 ENOG4105CJN penicillin-binding protein BA_4055 ENOG4105CJN penicillin-binding protein BA_4056 ENOG41068DC Essential cell division protein (By similarity) BA_4063 ENOG4105KNH Nucleic acid-binding protein BA_4074 ENOG4105XSJ toxin secretion phage lysis holin BA_4092 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BA_4094 ENOG4105CAR Terminase, large subunit BA_4112 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BA_4115 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA_4126 ENOG4108IMY Transcriptional regulator BA_4134 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BA_4136 ENOG41063PX domain protein BA_4137 ENOG4105D78 K07001 NTE family protein BA_4138 ENOG4105H20 Sporulation integral membrane protein YlbJ BA_4140 ENOG4106H78 methyltransferase BA_4144 ENOG4107TB6 phosphoglycerate mutase BA_4147 ENOG4106UY4 Inherit from COG: Scp-like extracellular BA_4157 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BA_4158 ENOG4105CNI cell division protein FtsW BA_4161 ENOG4108IAB Phoh family BA_4165 ENOG4105QA2 BA_4166 ENOG4105CI3 gtp-binding protein typa BA_4168 ENOG4105ECY inositol monophosphatase BA_4172 ENOG4105CXN decarboxylase BA_4182 ENOG4105C7S Dehydrogenase BA_4183 ENOG4105CPP Dehydrogenase, E1 component BA_4187 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BA_4188 ENOG4108X4Q Hydrolase BA_4190 ENOG4105CN5 Metallo-Beta-Lactamase BA_4191 ENOG4107ZYR domain protein BA_4198 ENOG4108XRC Protein of unknown function (DUF458) BA_4200 ENOG4107IN1 Protein of unknown function (DUF1797) BA_4203 ENOG4105EPM Diguanylate phosphodiesterase BA_4204 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BA_4208 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BA_4210 ENOG4105UIN BA_4223 ENOG4108HGU Histidine kinase BA_4225 ENOG4105CHM Aminotransferase BA_4226 ENOG4105FKQ transcriptional regulator BA_4227 ENOG4105EG2 ABC transporter, permease BA_4229 ENOG4107FKK extracellular solute-binding protein family 1 BA_4231 ENOG4105CG3 alpha amylase, catalytic region BA_4240 ENOG4105CHU acetyl-coa acetyltransferase BA_4248 ENOG4105K7K Transcriptional regulator BA_4249 ENOG4105DTD Dehydrogenase BA_4251 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BA_4253 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BA_4258 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BA_4263 ENOG4106TD9 Diguanylate cyclase BA_4267 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BA_4270 ENOG4105CID antiterminator BA_4272 ENOG4105FDP GntR family transcriptional regulator BA_4274 ENOG4105CE4 GlcNAc 6-P deacetylase BA_4283 ENOG4107ZE5 PPIases accelerate the folding of proteins BA_4284 ENOG4105PTM secreted protein BA_4285 ENOG4105J7I hydrolase BA_4288 ENOG4105CZ3 stage V sporulation protein ad BA_4289 ENOG41090VF Stage v sporulation protein ac BA_4293 ENOG4105C8J )-transporter BA_4294 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA_4296 ENOG41082AN stage II sporulation protein BA_4297 ENOG4105DZ1 carboxypeptidase BA_4298 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BA_4299 ENOG4105DVE abc transporter atp-binding protein BA_4306 ENOG4105D7N magnesium and cobalt transport protein CorA BA_4311 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BA_4313 ENOG4105I3K Ferric uptake regulator, Fur family BA_4314 ENOG4105MZ9 stage II sporulation protein m BA_4318 ENOG4105CPC Aldo Keto reductase BA_4320 ENOG4105RHY Pfam:UPF0157 BA_4324 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BA_4326 ENOG4105ETE Transcriptional regulator (LacI family BA_4327 ENOG4108YM7 Gcn5-related n-acetyltransferase BA_4331 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BA_4332 ENOG4108R6K riboflavin synthase, subunit alpha BA_4336 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BA_4337 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BA_4338 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BA_4339 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BA_4341 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BA_4345 ENOG4105DFD Na H antiporter BA_4346 ENOG4105CGH 5'-nucleotidase BA_4354 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BA_4357 ENOG4108IXY short-chain dehydrogenase reductase BA_4359 ENOG4105II7 pyrroline-5-carboxylate reductase BA_4360 ENOG4105EJQ L-serine dehydratase BA_4366 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BA_4368 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BA_4369 ENOG4105D9U N-acetyltransferase BA_4372 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BA_4373 ENOG4108QEG Membrane BA_4374 ENOG4105CDA abc transporter atp-binding protein BA_4375 ENOG4105E5Q amino acid AbC transporter BA_4376 ENOG4108HW3 (ABC) transporter BA_4379 ENOG4105G7B Protein of unknown function (DUF2992) BA_4380 ENOG4105E09 nadh pyrophosphatase BA_4382 ENOG4105C7S Dehydrogenase BA_4383 ENOG4105CPP Dehydrogenase, E1 component BA_4387 ENOG4107RDP Dehydrogenase BA_4389 ENOG4108JUB Transcriptional regulator BA_4391 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BA_4394 ENOG4107QQR Sporulation BA_4396 ENOG4105S1Z Stage IV sporulation protein B BA_4397 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BA_4399 ENOG4105DX0 Hemolysin A BA_4402 ENOG4105CTB Polyprenyl synthetase BA_4407 ENOG4108ZSR alkaline shock protein BA_4408 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BA_4412 ENOG410644B Stage III sporulation protein af BA_4414 ENOG4105KQ4 Stage iii sporulation protein ad BA_4415 ENOG4108CQH stage III sporulation protein AC BA_4416 ENOG4105KR5 Stage iii sporulation protein BA_4417 ENOG4105CD2 stage iii sporulation protein aa BA_4422 ENOG4105DC7 peptidase M24 BA_4425 ENOG4105CBJ Metal-dependent enzyme BA_4427 ENOG4107YBY Hydrolase BA_4431 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BA_4432 ENOG4105WZW rhodanese family BA_4436 ENOG41080TC multidrug resistance protein BA_4444 ENOG4105CJ1 ABC, transporter BA_4445 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BA_4450 ENOG4105C0D helicase BA_4477 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BA_4478 ENOG4105C3R Methionine synthase BA_4480 ENOG4105C28 cystathionine BA_4481 ENOG4105C28 cystathionine BA_4485 ENOG4105C5X domain protein BA_4487 ENOG4105DKQ ROK family BA_4489 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BA_4492 ENOG4108UTW Plays a role in the regulation of phosphate uptake BA_4493 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BA_4494 ENOG4105E2Z phosphate ABC transporter (Permease BA_4495 ENOG4105C8U phosphate abc transporter BA_4496 ENOG4105PWN phosphate abc transporter BA_4497 ENOG4107RF6 penicillin-binding protein BA_4499 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BA_4503 ENOG4105N80 Ferric uptake regulator, Fur family BA_4505 ENOG4105FDK ABC transporter BA_4506 ENOG4108JYZ YitT family BA_4507 ENOG41069ZM Protein of unknown function (DUF2624) BA_4512 ENOG4105EGD dinuclear metal center protein, YbgI family BA_4515 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA_4516 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BA_4524 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BA_4525 ENOG4105KG3 cytidine deaminase BA_4526 ENOG4107YR5 Diacylglycerol kinase BA_4528 ENOG4105CTJ Metal Dependent Phosphohydrolase BA_4529 ENOG4105C9A Phoh family BA_4532 ENOG41068P3 sporulation protein YqfC BA_4533 ENOG4105KTH gatB Yqey BA_4535 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BA_4536 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BA_4540 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BA_4542 ENOG4105CSA Coproporphyrinogen iii oxidase BA_4543 ENOG4105KVH Transcriptional regulator BA_4548 ENOG4105TQK DNA polymerase iii, delta' subunit BA_4551 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BA_4552 ENOG4108UK2 deaminase BA_4553 ENOG4105KQC Competence protein BA_4555 ENOG4105DXX methyltransferase BA_4557 ENOG4108WF2 Metal Dependent Phosphohydrolase BA_4560 ENOG410812S Rna-binding protein BA_4562 ENOG4105CQW ribosome biogenesis GTPase YqeH BA_4563 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BA_4566 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA_4571 ENOG4108TVJ Nitroreductase BA_4574 ENOG4105G6Z alkaline phosphatase BA_4577 ENOG4108MUZ hydrolase BA_4584 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BA_4586 ENOG4105MIR Phenylalanine 4-monooxygenase BA_4596 ENOG4105S6R Iron-hydroxamate transporter permease subunit BA_4597 ENOG4108V5C ABC transporter BA_4599 ENOG4108EKI Dehydrogenase BA_4600 ENOG4105C28 cystathionine BA_4606 ENOG4107XRG penicillin-binding protein BA_4609 ENOG4105CFP Peptidase U32 BA_4610 ENOG4105XYU peptidase (U32 family) BA_4611 ENOG4108VQJ O-methyltransferase BA_4612 ENOG4105HHA aminodeoxychorismate lyase BA_4616 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BA_4618 ENOG4105C02 permease BA_4621 ENOG41060CR BA_4622 ENOG4105C7H Helicase, RecD TraA family BA_4625 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BA_4626 ENOG4105C3J Cysteine desulfurase BA_4628 ENOG4105D1H recombination factor protein RarA BA_4629 ENOG4108VCI transcription factor, rsfa family BA_4630 ENOG4105CUZ uba thif-type nad fad binding protein BA_4633 ENOG4105CUT histidyl-tRNA synthetase BA_4637 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BA_4639 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BA_4640 ENOG41076HS cation diffusion facilitator family transporter BA_4641 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BA_4643 ENOG4105CKP Polysaccharide Biosynthesis Protein BA_4644 ENOG4108QG2 Membrane BA_4646 ENOG4105VIE preprotein translocase, subunit YajC BA_4649 ENOG41061AI Protein of unknown function (DUF2905) BA_4652 ENOG4108HUF Transporter BA_4655 ENOG41082BM Transcriptional regulator, arsr family BA_4661 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BA_4662 ENOG4108IYU L-aspartate oxidase BA_4665 ENOG4108RPX mosc domain containing protein BA_4666 ENOG4105CQC Prephenate dehydratase BA_4672 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BA_4675 ENOG4105X36 (ribosomal) protein BA_4677 ENOG4105C03 ribonuclease BA_4680 ENOG4107QMS site-determining protein BA_4683 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BA_4684 ENOG4105DFF Rod shape-determining protein mreb BA_4689 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BA_4690 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BA_4692 ENOG41068KH stage VI sporulation protein D BA_4694 ENOG4105D52 delta-aminolevulinic acid dehydratase BA_4699 ENOG4105K56 Transcriptional regulator BA_4703 ENOG4108IUQ atp-dependent protease BA_4710 ENOG4108QCI YvbH-like oligomerisation region BA_4713 ENOG4105M59 Phosphodiesterase, mj0936 family BA_4714 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BA_4716 ENOG4108XJQ germination protein BA_4718 ENOG4108PCX Major Facilitator BA_4721 ENOG4105KBX Transcriptional regulator, TetR family BA_4724 ENOG4105PFC Transcriptional regulator BA_4727 ENOG4105DZC cytosine deaminase BA_4728 ENOG4105DZC cytosine deaminase BA_4729 ENOG4105DEF Extracellular solute-binding protein, family 5 BA_4731 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BA_4734 ENOG4108JQ7 (ABC) transporter BA_4736 ENOG4105DY9 regulatoR BA_4739 ENOG41067S9 phage shock protein C, PspC BA_4740 ENOG4108JCI Transcriptional regulator BA_4742 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BA_4743 ENOG4108Z40 Transcriptional regulator BA_4744 ENOG4105RHA ABC transporter, permease BA_4745 ENOG4108IUX (ABC) transporter BA_4746 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BA_4748 ENOG4105E14 MotA TolQ exbB proton channel BA_4750 ENOG4108VXD carboxy-peptidase BA_4753 ENOG4105E33 succinate dehydrogenase BA_4755 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BA_4758 ENOG4105K63 Thioredoxin BA_4759 ENOG4105C10 Electron transfer flavoprotein BA_4760 ENOG4105BZJ Electron transfer flavoprotein BA_4761 ENOG41060WC Enoyl-CoA hydratase BA_4762 ENOG4107Z3H Transcriptional regulator, TetR family BA_4763 ENOG4105CEY Amp-dependent synthetase and ligase BA_4766 ENOG4105J76 Periplasmic binding protein BA_4767 ENOG4105S6R Iron-hydroxamate transporter permease subunit BA_4777 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BA_4780 ENOG4105DR4 Methyltransferase BA_4783 ENOG4105KFN sortase, SrtB family BA_4784 ENOG4105E0A ABC, transporter BA_4787 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BA_4789 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BA_4792 ENOG4105FE9 pseudouridine synthase BA_4795 ENOG4105DCG PHP domain protein BA_4802 ENOG4105C5S asparaginyl-tRNA synthetase BA_4803 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BA_4805 ENOG4108RWN rrna methyltransferase BA_4812 ENOG4105C0R drug resistance transporter emrb qaca subfamily BA_4813 ENOG4105CW7 secretion protein, HlyD family BA_4814 ENOG4108JGH Tetr family transcriptional regulator BA_4815 ENOG4105CN9 Peptidase m42 family protein BA_4819 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BA_4820 ENOG4105C22 threonyL-tRNA synthetase BA_4821 ENOG4108TDW sporulation protein YtxC BA_4825 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BA_4827 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BA_4828 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BA_4830 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BA_4831 ENOG4105C2M dna polymerase I BA_4832 ENOG4105BZU Histidine kinase BA_4833 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BA_4838 ENOG4108HMX isocitrate dehydrogenase (NADP) BA_4839 ENOG4105BZN citrate synthase BA_4841 ENOG4108REF Sporulation integral membrane protein ytvi BA_4842 ENOG4105FS0 cytoplasmic membrane protein BA_4847 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BA_4848 ENOG4105C6K Malic enzyme BA_4849 ENOG4105C0B DNA polymerase III (alpha subunit) BA_4850 ENOG4105VV2 BA_4852 ENOG4105SFS phosphoesterase RecJ domain protein BA_4861 ENOG4105DC7 peptidase M24 BA_4868 ENOG4105Z7P Acetyltransferase (GNAT) family BA_4869 ENOG41082W1 Cupin 2, conserved barrel domain protein BA_4871 ENOG4105VZ8 Transcriptional regulator BA_4875 ENOG4107YZX Universal stress protein BA_4884 ENOG4108JYZ YitT family BA_4888 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BA_4890 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BA_4891 ENOG4105KBJ sporulation protein ytfj BA_4894 ENOG4105EFZ amidohydrolase BA_4896 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BA_4902 ENOG4106KR7 LysR family Transcriptional regulator BA_4906 ENOG4105C28 cystathionine BA_4911 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BA_4913 ENOG4105EMN RNA polymerase sigma factor BA_4916 ENOG4105F1V Acetoin utilization protein BA_4917 ENOG4105W87 Cbs domain BA_4918 ENOG4105DGU Histone deacetylase BA_4920 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BA_4922 ENOG4107SNB ankyrin repeat protein YahD BA_4923 ENOG4105EP9 oxidoreductase BA_4929 ENOG4105ETE Transcriptional regulator (LacI family BA_4933 ENOG4105C88 aminopeptidase BA_4943 ENOG4108VDD TRNA binding domain protein BA_4949 ENOG4105C8F Beta-lactamase domain protein BA_4952 ENOG4108V15 phosphotransferase enzyme family BA_4953 ENOG4108IUM Glycogen debranching enzyme BA_4957 ENOG4105YW5 deoR family transcriptional regulator BA_4960 ENOG4105CBX hi0933 family BA_4967 ENOG4108VJ1 Transcriptional regulator (CarD family BA_4968 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BA_4969 ENOG4105CSC Glucose uptake protein BA_4972 ENOG4108ZAF Molybdopterin BA_4973 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BA_4974 ENOG4105CVM Molybdenum cofactor synthesis domain protein BA_4976 ENOG4105D06 uba thif-type nad fad binding protein BA_4981 ENOG41085GJ domain protein BA_4983 ENOG4105DWV Homoserine O-trans-acetylase BA_4985 ENOG4108B31 Spore germination protein BA_4992 ENOG410605W Major Facilitator BA_4993 ENOG4107S91 Sodium hydrogen exchanger BA_4994 ENOG4105NCW Trka-c domain protein BA_4997 ENOG4105C19 ABC transporter BA_5001 ENOG4105N5T Radical SAM Protein BA_5003 ENOG4105DA5 (ABC) transporter BA_5009 ENOG4105E8V Alpha Beta Hydrolase Fold protein BA_5010 ENOG4108Z0R Transferase BA_5011 ENOG4105YVM Phosphoesterase, PA-phosphatase related BA_5012 ENOG4105BZF Glycosyl transferase (Group 1 BA_5014 ENOG4108RIR Molybdenum cofactor biosynthesis protein BA_5027 ENOG4105EGD dinuclear metal center protein, YbgI family BA_5028 ENOG4105BZU Histidine kinase BA_5029 ENOG4105BZU Histidine kinase BA_5030 ENOG4107S9D Alpha beta hydrolase BA_5031 ENOG4107T7U Sulfatase BA_5036 ENOG4105D2X ABC transporter substrate-binding protein BA_5038 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BA_5049 ENOG4108V2W Carbonate dehydratase BA_5050 ENOG4105C4M (Ubiquinol oxidase) subunit I BA_5051 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BA_5061 ENOG41087YS Phage shock protein A BA_5067 ENOG4105BZU Histidine kinase BA_5068 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA_5074 ENOG4108UGV hypoxanthine phosphoribosyltransferase BA_5075 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BA_5082 ENOG4107ZTW SNARE associated Golgi BA_5085 ENOG4105C19 ABC transporter BA_5086 ENOG41086D8 Transcriptional regulator BA_5095 ENOG4105C6Z Gluconate BA_5096 ENOG4105FDP GntR family transcriptional regulator BA_5100 ENOG41069H0 dihydroorotase EC 3.5.2.3 BA_5107 ENOG4105DTQ mandelate racemase muconate lactonizing BA_5109 ENOG4108IPT Naphthoate synthase BA_5110 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BA_5111 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BA_5112 ENOG4105E4F Isochorismate synthase BA_5113 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BA_5115 ENOG4105VEQ Cold shock protein BA_5120 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BA_5122 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BA_5125 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BA_5127 ENOG4105KT7 mgtC SapB transporter BA_5128 ENOG4107PBV potassium channel BA_5130 ENOG4107QYV phosphohexose isomerase BA_5131 ENOG4105WG9 Conserved Protein BA_5133 ENOG4105CHM Aminotransferase BA_5134 ENOG4108ZB6 transcriptional regulator AsnC family BA_5135 ENOG4105C5I Dehydrogenase BA_5136 ENOG4108MUZ hydrolase BA_5138 ENOG4105C87 Aminotransferase class I and II BA_5141 ENOG4105Y38 Kinase-associated protein B BA_5143 ENOG4107R3E Citrate transporter BA_5147 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BA_5148 ENOG4105KA0 thioesterase Superfamily protein BA_5152 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BA_5156 ENOG41069ER domain protein BA_5159 ENOG4105CEP NADH dehydrogenase BA_5165 ENOG4105EWC Purine nucleoside phosphorylase BA_5169 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BA_5175 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BA_5176 ENOG4105C4B ABC transporter, permease BA_5177 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BA_5186 ENOG41083MR nifu domain-containing protein BA_5189 ENOG4108W5N phosphatidylglycerophosphatase a BA_5191 ENOG4105DYS nad(p)h dehydrogenase (quinone) BA_5192 ENOG4105D4U had-superfamily hydrolase, subfamily iia BA_5195 ENOG4105CBT Fructose-1,6-bisphosphatase BA_5198 ENOG4105MMD transcriptional regulator BA_5199 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BA_5200 ENOG4107TXC Transcriptional regulator BA_5201 ENOG41090T1 Membrane BA_5206 ENOG4105FAA peptidase M23 BA_5208 ENOG4105KZD Domain of unknown function (DUF1805) BA_5213 ENOG4105DIW FeS assembly protein SUFB BA_5214 ENOG4108UNV SUF system FeS assembly protein, NifU family BA_5215 ENOG4105C9B Cysteine desulfurase BA_5216 ENOG4105JRK feS assembly protein SufD BA_5217 ENOG4105C3K feS assembly ATPase SufC BA_5219 ENOG4105D01 (LipO)protein BA_5220 ENOG4105D01 (LipO)protein BA_5221 ENOG4108UMI ABC transporter, permease BA_5229 ENOG41080E8 Transcriptional regulator, Spx MgsR family BA_5240 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BA_5245 ENOG4108W8B Beta-lactamase domain protein BA_5246 ENOG4105C1G acyl-Coa dehydrogenase BA_5248 ENOG4105CHU acetyl-coa acetyltransferase BA_5252 ENOG4105DZ1 carboxypeptidase BA_5256 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BA_5260 ENOG4108SUT Major Facilitator Superfamily BA_5261 ENOG4107R7I amino acid BA_5263 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BA_5265 ENOG4107AYK membrAne BA_5272 ENOG4107ZTW SNARE associated Golgi BA_5274 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BA_5275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA_5276 ENOG4105BZU Histidine kinase BA_5278 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BA_5281 ENOG4105VG1 fes assembly suf system protein BA_5282 ENOG4105D4Y metalloprotease BA_5286 ENOG4107S91 Sodium hydrogen exchanger BA_5287 ENOG4105NCW Trka-c domain protein BA_5290 ENOG4108RMU ferritin dps family protein BA_5294 ENOG4108URH decarboxylase BA_5298 ENOG4105D9N nucleoside BA_5299 ENOG4105D9N nucleoside BA_5302 ENOG4108RYK Nad-dependent epimerase dehydratase BA_5308 ENOG4105CV8 reductase BA_5309 ENOG4105F27 Major Facilitator BA_5311 ENOG4105KVH Transcriptional regulator BA_5314 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BA_5315 ENOG4105D4A Cell wall formation (By similarity) BA_5317 ENOG4105C8Q Methyl-accepting chemotaxis BA_5319 ENOG4105WMR Protein CrcB homolog BA_5320 ENOG4105WMR Protein CrcB homolog BA_5323 ENOG4108MK9 spermidine N(1)-acetyltransferase BA_5324 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BA_5327 ENOG4108IPW abc transporter atp-binding protein BA_5328 ENOG4105CM4 permease protein BA_5334 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BA_5336 ENOG4105XZU Preprotein translocase, subunit SecG BA_5358 ENOG4105EFC phage portal protein HK97 family BA_5363 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BA_5365 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BA_5366 ENOG4105CP7 Triose-phosphate isomerase BA_5372 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA_5375 ENOG41090VF Stage v sporulation protein ac BA_5376 ENOG4105CZ3 stage V sporulation protein ad BA_5379 ENOG4105H67 Protein of unknown function (DUF421) BA_5380 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BA_5381 ENOG4105KRI phosphocarrier protein (HPr BA_5383 ENOG4105CHW UPF0052 protein BA_5385 ENOG4108Z4K mutator MutT protein BA_5387 ENOG4105C3M thioredoxin reductase BA_5389 ENOG4108S4C acetyltransferase BA_5393 ENOG41086DT Membrane protein of unknown function BA_5395 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BA_5396 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BA_5397 ENOG4105D7V transposase BA_5400 ENOG4107TXC Transcriptional regulator BA_5405 ENOG4105HMI Membrane BA_5406 ENOG4105DUM transcriptional regulator, lysR family BA_5408 ENOG4108WS4 fmn reductase BA_5411 ENOG4105BZ1 (ABC) transporter BA_5414 ENOG4105CN1 protease BA_5415 ENOG4105CRP Part of the ABC transporter FtsEX involved in BA_5416 ENOG4105CAK Cell division ATP-binding protein ftsE BA_5421 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BA_5422 ENOG4105MS2 ribosomal subunit Interface protein BA_5424 ENOG4105VEQ Cold shock protein BA_5425 ENOG41081UC Inherit from COG: Competence protein BA_5428 ENOG4105KVH Transcriptional regulator BA_5431 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BA_5432 ENOG4108KGH TRANSCRIPTIONal BA_5433 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BA_5434 ENOG4105C6Y Udp-glucose 6-dehydrogenase BA_5435 ENOG4105ESV Glycosyl transferase, family 4 BA_5437 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BA_5440 ENOG410901P UPF0249 protein BA_5441 ENOG4105F8D glycoside hydrolase family 4 BA_5442 ENOG4105VCP PTS System BA_5443 ENOG4105CK1 PTS System BA_5445 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BA_5446 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BA_5447 ENOG4105VCP PTS System BA_5449 ENOG4105VZJ PTS System BA_5452 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BA_5453 ENOG4105ECB domain protein BA_5454 ENOG4107RSM transcriptional regulator BA_5464 ENOG4105DAA L-lactate BA_5467 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BA_5470 ENOG4105E0M Sulfatase BA_5479 ENOG4105C94 Transporter BA_5481 ENOG41069ER domain protein BA_5486 ENOG4105KBK Zinc finger, swim domain protein BA_5487 ENOG4105C0D helicase BA_5493 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA_5495 ENOG4107RBB ABC transporter, permease BA_5496 ENOG4105C19 ABC transporter BA_5500 ENOG4105CXY transporter BA_5503 ENOG4105BZU Histidine kinase BA_5504 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA_5505 ENOG4105CMR udp-glucose 4-epimerase BA_5509 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BA_5510 ENOG4105EY8 ABC transporter BA_5521 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BA_5524 ENOG4105FRN stage II sporulation protein BA_5531 ENOG4106778 Protein of unknown function (DUF1146) BA_5532 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BA_5533 ENOG4105C8S subunit m BA_5534 ENOG4105D65 subunit l BA_5539 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BA_5540 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BA_5542 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BA_5543 ENOG4105BZU Histidine kinase BA_5553 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BA_5554 ENOG41062M3 atp synthase BA_5560 ENOG4108YZG isomerase BA_5564 ENOG4108VGI doxx family BA_5565 ENOG4107XC4 flavin reductase domain protein, FMN-binding BA_5568 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BA_5570 ENOG4108ZXQ stage ii sporulation protein r BA_5571 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BA_5572 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BA_5575 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BA_5576 ENOG4105CBT Fructose-1,6-bisphosphatase BA_5578 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BA_5586 ENOG4105C1G acyl-Coa dehydrogenase BA_5587 ENOG4105C1G acyl-Coa dehydrogenase BA_5588 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BA_5590 ENOG4105DF6 Fe-S oxidoreductase BA_5593 ENOG4105BZU Histidine kinase BA_5598 ENOG4105BZU Histidine kinase BA_5599 ENOG4105KCT ABC transporter BA_5600 ENOG4108M15 ABC transporter BA_5601 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BA_5606 ENOG4105IIU Aminopeptidase BA_5610 ENOG4105EMN RNA polymerase sigma factor BA_5612 ENOG410684U Domain of unknown function (DUF1934) BA_5617 ENOG4105CYW agmatinase BA_5620 ENOG4105DXB Major Facilitator superfamily BA_5621 ENOG4107SWG transcriptional regulator MERR family BA_5622 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BA_5623 ENOG4105BZ4 penicillin-binding protein BA_5624 ENOG4108XFG YwhD family BA_5625 ENOG4108Z4T Peptidase M50 BA_5626 ENOG41069HH 4-oxalocrotonate tautomerase BA_5627 ENOG4105DCI Phosphohydrolase BA_5628 ENOG4108MES Periplasmic binding protein BA_5629 ENOG4105E0A ABC, transporter BA_5630 ENOG4105EHG Permease protein BA_5633 ENOG4108VCI transcription factor, rsfa family BA_5636 ENOG4108IJ2 phosphate acetyltransferase BA_5640 ENOG4108VKI Cell wall hydrolase BA_5646 ENOG410667J hydrolase BA_5647 ENOG4105VCH membrane BA_5649 ENOG4108TU7 Inherit from COG: (ABC) transporter BA_5650 ENOG4105CJ1 ABC, transporter BA_5651 ENOG41090WU lipolytic protein G-D-S-L family BA_5654 ENOG4105D6E homoserine dehydrogenase BA_5659 ENOG4108Y4K DNA-binding transcriptional activator BA_5661 ENOG4105WH1 Two component transcriptional regulator luxr family BA_5663 ENOG4105DWF phosphomethylpyrimidine kinase BA_5664 ENOG4105BZU Histidine kinase BA_5665 ENOG4105VCD cytoplasmic protein BA_5666 ENOG4105D22 carbon starvation protein BA_5667 ENOG4105DY9 regulatoR BA_5668 ENOG41079KZ Major Facilitator Superfamily BA_5672 ENOG4105EN6 Membrane BA_5673 ENOG4106YBV Methyl-accepting chemotaxis BA_5675 ENOG4108S4H thioesterase Superfamily protein BA_5677 ENOG4105JEU Glycosyl transferase, family 2 BA_5678 ENOG4105C5H ABC transporter BA_5684 ENOG4105CKK Glycosyl transferase, family 2 BA_5685 ENOG41067SE Tetr family transcriptional regulator BA_5687 ENOG4105E0X reductase BA_5688 ENOG4106F5Q Membrane BA_5691 ENOG4105DY9 regulatoR BA_5692 ENOG4108HRK Histidine kinase BA_5693 ENOG4107RGD Major Facilitator superfamily BA_5696 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BA_5698 ENOG4105IW1 AmiS UreI transporter BA_5700 ENOG4105CMR udp-glucose 4-epimerase BA_5701 ENOG4108UT2 hemolysin iii BA_5703 ENOG4105C1J atp-dependent rna helicase BA_5706 ENOG4105DPN Oligoendopeptidase f BA_5710 ENOG4105C0H protease BA_5711 ENOG4105Q2H domain protein BA_5714 ENOG4105BZU Histidine kinase BA_5715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA_5717 ENOG4105CDU Replicative dna helicase BA_5719 ENOG4105BZR domain protein BA_5720 ENOG4108XMW Membrane BA_5722 ENOG4108UUM single-stranded DNA-binding protein BA_5724 ENOG4105C3G gtp-binding protein BA_5725 ENOG4105VDK protein, conserved in bacteria BA_5726 ENOG4105D8X mechanosensitive ion channel BA_5728 ENOG4108ZDA Sporulation protein YyaC BA_5729 ENOG4105FA0 parb-like partition protein BA_5730 ENOG4107QJE Chromosome Partitioning Protein BA_5734 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BA_5736 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BA_5858 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation