locus-tag class description H9401_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H9401_0003 ENOG410848D S4 domain protein YaaA H9401_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H9401_0008 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) H9401_0014 ENOG4105ZMH deoxynucleoside kinase H9401_0016 ENOG4105GTG Isochorismatase H9401_0017 ENOG4108Z6B deaminase H9401_0018 ENOG4105C6E dna polymerase iii H9401_0022 ENOG41067KS pro-sigma K processing H9401_0024 ENOG4105CXN decarboxylase H9401_0026 ENOG4105FA2 dna polymerase iii H9401_0027 ENOG4105MA4 psp1 domain protein H9401_0029 ENOG41060K3 Methyltransferase H9401_0031 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) H9401_0032 ENOG4105KRN Transcriptional regulator, abrb family H9401_0034 ENOG4105F8V Hydrolase, tatD family H9401_0035 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) H9401_0037 ENOG4105XFA sporulation peptidase YabG H9401_0038 ENOG4105W42 Veg protein H9401_0041 ENOG4105DFT pur operon repressor H9401_0042 ENOG4105KME endoribonuclease L-psp H9401_0045 ENOG4105C5T Phosphoribosyl pyrophosphate synthase H9401_0046 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) H9401_0048 ENOG4108JA2 transcriptioN-repair coupling factor H9401_0049 ENOG4108M14 stage v sporulation protein t H9401_0051 ENOG4108IY2 MazG family H9401_0052 ENOG41082I2 s4 domain protein H9401_0053 ENOG4105VYY sporulation protein yabp H9401_0056 ENOG41060GV RNA binding s1 domain protein H9401_0058 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) H9401_0059 ENOG4108UGV hypoxanthine phosphoribosyltransferase H9401_0060 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H9401_0063 ENOG4105C6T cysteine synthase H9401_0064 ENOG4105CRQ synthase (Component I) H9401_0065 ENOG4105DDQ anthranilate synthase H9401_0066 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 H9401_0067 ENOG4105EEI dihydropteroate synthase H9401_0068 ENOG4105KRF dihydroneopterin aldolase H9401_0069 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase H9401_0070 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H9401_0073 ENOG4108Z0C Uvrb UvrC protein H9401_0076 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) H9401_0078 ENOG4105CTP PilT protein domain protein H9401_0082 ENOG4105D7W serine acetyltransferase H9401_0085 ENOG4105C2N RNA methyltransferase TrmH family group 3 H9401_0086 ENOG4105M0M Tetracycline resistance protein H9401_0087 ENOG4105QIV RNA polymerase H9401_0089 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) H9401_0094 ENOG4107Y49 methyltransferase H9401_0096 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H9401_0097 ENOG4105XPM ribosomal protein H9401_0118 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) H9401_0123 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) H9401_0125 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) H9401_0127 ENOG41067V7 50S ribosomal protein L36 H9401_0133 ENOG4108JJB ABC transporter H9401_0134 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) H9401_0135 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) H9401_0140 ENOG4105D1F ATP-binding protein H9401_0143 ENOG4108NMV polysaccharide deacetylase H9401_0148 ENOG4105C8B TIGR00159 family H9401_0149 ENOG4107U5W ybbr family H9401_0151 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) H9401_0152 ENOG4108VQT Alpha beta hydrolase fold protein H9401_0154 ENOG4105CMG Carbohydrate kinase H9401_0155 ENOG4105CMG Carbohydrate kinase H9401_0157 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) H9401_0158 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein H9401_0165 ENOG4108PSK reductase H9401_0166 ENOG4108UMI ABC transporter, permease H9401_0167 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H9401_0168 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H9401_0169 ENOG4105D01 (LipO)protein H9401_0170 ENOG4105EE1 crotonyl-CoA reductase H9401_0172 ENOG4105IQ5 FAD linked oxidase domain protein H9401_0175 ENOG4105C2C drug resistance transporter, Bcr CflA H9401_0178 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H9401_0179 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H9401_0180 ENOG4105C3U ABC transporter H9401_0181 ENOG4108JQ7 (ABC) transporter H9401_0187 ENOG4108J59 Extracellular solute-binding protein, family 5 H9401_0188 ENOG4108J59 Extracellular solute-binding protein, family 5 H9401_0190 ENOG4105II7 pyrroline-5-carboxylate reductase H9401_0191 ENOG4107XDY Nicotinamide Mononucleotide Transporter H9401_0193 ENOG4105E0C molybdate abc transporter H9401_0194 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein H9401_0195 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein H9401_0196 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family H9401_0197 ENOG4105EGI Transcriptional regulator H9401_0200 ENOG4105F6E Acyl-transferase H9401_0203 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) H9401_0206 ENOG4108RE7 deoxyribonuclease H9401_0207 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) H9401_0212 ENOG4105C5H ABC transporter H9401_0215 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein H9401_0217 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H9401_0218 ENOG4105C3U ABC transporter H9401_0219 ENOG4108JQ7 (ABC) transporter H9401_0220 ENOG410667J hydrolase H9401_0227 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase H9401_0228 ENOG4105ERH Fumarylacetoacetate hydrolase H9401_0231 ENOG4105CPF Cell wall formation (By similarity) H9401_0232 ENOG4105CPF Cell wall formation (By similarity) H9401_0233 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) H9401_0236 ENOG4107ZXI Rhomboid family H9401_0238 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein H9401_0239 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H9401_0241 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) H9401_0244 ENOG4105K8N protein family UPF0079, ATPase H9401_0245 ENOG41072GX Peptidase M22 Glycoprotease H9401_0246 ENOG410801F ribosomal-protein-alanine acetyltransferase H9401_0247 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H9401_0248 ENOG4105C5H ABC transporter H9401_0250 ENOG4108TYN CAAX amino terminal protease family protein H9401_0254 ENOG4105C7N Xanthine uracil vitamin C permease H9401_0256 ENOG4105BZU Histidine kinase H9401_0264 ENOG4108SHN Glycosyl transferase, family 2 H9401_0265 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) H9401_0266 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit H9401_0267 ENOG4105C83 adenylosuccinate lyase H9401_0269 ENOG4105VR9 phosphoribosylformylglycinamidine synthase H9401_0274 ENOG4108V3E phosphoribosylglycinamide formyltransferase H9401_0276 ENOG4105C12 Phosphoribosylglycinamide synthetase H9401_0281 ENOG4105C4R Atp-dependent dna helicase H9401_0287 ENOG4108W2Y isochorismatase H9401_0288 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H9401_0289 ENOG4108UMI ABC transporter, permease H9401_0290 ENOG4105D01 (LipO)protein H9401_0293 ENOG4105D0U Arsenite-activated ATPase (ArsA) H9401_0294 ENOG410834F Transcriptional regulator H9401_0295 ENOG4107I77 yiaA/B two helix domain H9401_0299 ENOG4105CBD Diacylglycerol kinase H9401_0300 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) H9401_0301 ENOG4108JPW Aminotransferase H9401_0303 ENOG4105C26 Dehydrogenase H9401_0304 ENOG4105KPY Small multidrug resistance protein H9401_0308 ENOG4105D9N nucleoside H9401_0309 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) H9401_0312 ENOG4108W15 Protein of unknown function (DUF1456) H9401_0315 ENOG4105DTQ mandelate racemase muconate lactonizing H9401_0317 ENOG4105DFD Na H antiporter H9401_0321 ENOG4105D3R alkyl hydroperoxide reductase H9401_0322 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) H9401_0324 ENOG4107W7X Aldolase H9401_0325 ENOG4105EHG Permease protein H9401_0326 ENOG4105DQ5 transport system permease protein H9401_0327 ENOG4108V5C ABC transporter H9401_0331 ENOG4106UIA H9401_0332 ENOG4106UIA H9401_0336 ENOG4105BZU Histidine kinase H9401_0340 ENOG410756H nucleotidyltransferase H9401_0341 ENOG4105D2S major facilitator superfamily H9401_0344 ENOG4105E5Q amino acid AbC transporter H9401_0345 ENOG4105EAB amino acid AbC transporter H9401_0347 ENOG4105C8Q Methyl-accepting chemotaxis H9401_0348 ENOG4105C8Q Methyl-accepting chemotaxis H9401_0350 ENOG4105CI1 PTS System H9401_0357 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter H9401_0360 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H9401_0363 ENOG4105C5H ABC transporter H9401_0368 ENOG41062JF Transcriptional regulator H9401_0372 ENOG4105DEU major facilitator superfamily H9401_0375 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) H9401_0378 ENOG4108N0M stress protein H9401_0379 ENOG4106FN3 tellurium resistance protein H9401_0380 ENOG4106FN3 tellurium resistance protein H9401_0381 ENOG4107TS3 membrane protein, TerC H9401_0382 ENOG4108TTB tellurium resistance protein H9401_0386 ENOG4105KJF protein tyrosine phosphatase H9401_0388 ENOG4107U9T Pfam:Ribonuclease_BN H9401_0389 ENOG4105C59 p-type ATPase H9401_0390 ENOG4108IPJ Membrane H9401_0392 ENOG4105C3F Signal peptidase i H9401_0395 ENOG4107ZTW SNARE associated Golgi H9401_0398 ENOG410606W general stress protein H9401_0399 ENOG4105UPD Calcium Proton H9401_0407 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) H9401_0408 ENOG4105VTR Integrase H9401_0461 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) H9401_0463 ENOG4108JUB Transcriptional regulator H9401_0465 ENOG4108IQI permease H9401_0471 ENOG4105CSV Glutaminase H9401_0474 ENOG4108A04 Beta-lactamase H9401_0477 ENOG4105CKK Glycosyl transferase, family 2 H9401_0479 ENOG4107QQG Dehydrogenase H9401_0480 ENOG4105C3I Nad-dependent epimerase dehydratase H9401_0483 ENOG4105F1A Pyruvate formate-lyase H9401_0487 ENOG4105CI2 imidazolone-5-propionate hydrolase H9401_0488 ENOG4105ECP epimerase H9401_0494 ENOG41067AE Membrane-bound metal-dependent hydrolase H9401_0495 ENOG4105CEN a g-specific adenine glycosylase H9401_0496 ENOG4106BXE H9401_0501 ENOG4105BZ1 (ABC) transporter H9401_0502 ENOG4107NBY Membrane H9401_0503 ENOG4105CBC glutamate synthase H9401_0505 ENOG4108IUW ABC transporter H9401_0509 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H9401_0510 ENOG4105G5W regulator Fur family H9401_0515 ENOG4108JQC penicillin-binding protein 1A H9401_0516 ENOG4107ZQN disulfide bond H9401_0517 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) H9401_0519 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) H9401_0520 ENOG4105BZU Histidine kinase H9401_0521 ENOG4105CYN Serine protein kinase H9401_0525 ENOG4105C94 Transporter H9401_0528 ENOG4105DZ6 Band 7 protein H9401_0530 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism H9401_0531 ENOG4108MRH transcriptional regulatory protein H9401_0532 ENOG4105D4T Citrate transporter H9401_0536 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator H9401_0537 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H9401_0538 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component H9401_0540 ENOG4105BZ7 extracellular solute-binding protein family 1 H9401_0541 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) H9401_0542 ENOG4108STX response regulator H9401_0543 ENOG4105US7 Histidine kinase H9401_0548 ENOG4108MRH transcriptional regulatory protein H9401_0550 ENOG4105C6K Malic enzyme H9401_0552 ENOG4108UZ3 Transporter H9401_0553 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H9401_0555 ENOG4105BZU Histidine kinase H9401_0556 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H9401_0558 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) H9401_0559 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) H9401_0560 ENOG4108JB9 formate dehydrogenase H9401_0565 ENOG4105CUB amino acid H9401_0567 ENOG4105C59 p-type ATPase H9401_0568 ENOG4105DAP Nicotinate phosphoribosyltransferase H9401_0575 ENOG41073R8 VanW family H9401_0576 ENOG4108KGH TRANSCRIPTIONal H9401_0577 ENOG4105D9N nucleoside H9401_0578 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase H9401_0579 ENOG4105C37 (CBS) domain H9401_0580 ENOG4108IJ0 Aspartate ammonia-lyase H9401_0581 ENOG4105DAA L-lactate H9401_0584 ENOG4105DUX Transporter H9401_0585 ENOG4108MES Periplasmic binding protein H9401_0586 ENOG4105DQ5 transport system permease protein H9401_0587 ENOG4108IHU transport system permease protein H9401_0588 ENOG4105E0A ABC, transporter H9401_0589 ENOG4105DMQ Methyltransferase H9401_0591 ENOG4105EXW epimerase dehydratase H9401_0593 ENOG4107T89 von Willebrand factor, type A H9401_0594 ENOG4105GMT ATPase associated with various cellular activities aaa_5 H9401_0595 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) H9401_0598 ENOG4105BZU Histidine kinase H9401_0599 ENOG4105D5Q Arginine ornithine antiporter H9401_0600 ENOG4107414 GntR family transcriptional regulator H9401_0601 ENOG4105C5Y PTS System H9401_0602 ENOG4105CG3 alpha amylase, catalytic region H9401_0606 ENOG4105E1K spore germination protein H9401_0608 ENOG4105CRN Aminoglycoside phosphotransferase H9401_0609 ENOG4105BZG amino acid carrier protein H9401_0610 ENOG4105CDA abc transporter atp-binding protein H9401_0611 ENOG4105CT1 (ABC) transporter H9401_0612 ENOG4105EAD ABC transporter H9401_0613 ENOG4105DRP amino acid AbC transporter H9401_0614 ENOG4108IQI permease H9401_0619 ENOG4105D29 Helix-turn-helix type 11 domain protein H9401_0620 ENOG4105NAE bifunctional deaminase-reductase domain protein H9401_0621 ENOG4105BZU Histidine kinase H9401_0624 ENOG4105CHH sulfate transporter H9401_0625 ENOG41068KF Universal stress protein H9401_0627 ENOG4105DEF Extracellular solute-binding protein, family 5 H9401_0629 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H9401_0630 ENOG4108JQ7 (ABC) transporter H9401_0632 ENOG4105CXY transporter H9401_0633 ENOG41067TZ transcriptional regulator, MarR family H9401_0634 ENOG4105C0R drug resistance transporter emrb qaca subfamily H9401_0635 ENOG4105C0R drug resistance transporter emrb qaca subfamily H9401_0636 ENOG4105ETE Transcriptional regulator (LacI family H9401_0637 ENOG4108RVA ribokinase H9401_0639 ENOG4105C2J ABC transporter H9401_0640 ENOG4105CNN ABC, transporter H9401_0641 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H9401_0642 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H9401_0654 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) H9401_0655 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer H9401_0656 ENOG41069ER domain protein H9401_0657 ENOG4105VZ8 Transcriptional regulator H9401_0658 ENOG4107D63 H9401_0660 ENOG4105DUX Transporter H9401_0664 ENOG4105C85 amino acid H9401_0665 ENOG4105C7N Xanthine uracil vitamin C permease H9401_0673 ENOG4105BZ9 Cytochrome C oxidase, subunit I H9401_0674 ENOG4105E2S oxidase) subunit II H9401_0677 ENOG4106CAD Protein of unknown function (DUF3311) H9401_0678 ENOG4105E1V na solute symporter H9401_0681 ENOG4108NHD germination protein H9401_0682 ENOG4105CE1 Ferrous iron transport protein b H9401_0683 ENOG4105CE1 Ferrous iron transport protein b H9401_0684 ENOG4105CE1 Ferrous iron transport protein b H9401_0685 ENOG4105CVA phosphate H9401_0686 ENOG4105C8U phosphate abc transporter H9401_0687 ENOG4105E2Z phosphate ABC transporter (Permease H9401_0690 ENOG41080XQ Signal transduction protein with cbs domains H9401_0694 ENOG4105ETU transcriptional activator (TenA H9401_0696 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H9401_0698 ENOG4108VEU Thiamine monophosphate synthase H9401_0699 ENOG41080HI glycine oxidase H9401_0702 ENOG4105D06 uba thif-type nad fad binding protein H9401_0703 ENOG4105DWF phosphomethylpyrimidine kinase H9401_0711 ENOG4108INS Transcriptional regulator H9401_0714 ENOG4105C7N Xanthine uracil vitamin C permease H9401_0720 ENOG4105C5Y PTS System H9401_0727 ENOG4108B31 Spore germination protein H9401_0732 ENOG4107Y03 Nitroreductase H9401_0733 ENOG4105ED1 spovr family H9401_0738 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase H9401_0739 ENOG4105XTG Pfam:DUF156 H9401_0740 ENOG4105VFE sira family H9401_0741 ENOG4107TPS domain protein H9401_0742 ENOG4105VFE sira family H9401_0743 ENOG41085GJ domain protein H9401_0745 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase H9401_0746 ENOG41087NI Sulfite exporter TauE/SafE H9401_0748 ENOG4108KGH TRANSCRIPTIONal H9401_0753 ENOG4105EMD TRANSCRIPTIONal H9401_0754 ENOG4105VCP PTS System H9401_0755 ENOG4105VZJ PTS System H9401_0759 ENOG41069ER domain protein H9401_0760 ENOG4107RBB ABC transporter, permease H9401_0761 ENOG4105C19 ABC transporter H9401_0768 ENOG4105WEF catalase H9401_0775 ENOG4107T5V SNARE associated Golgi H9401_0781 ENOG4105CUB amino acid H9401_0782 ENOG4107RWR Sodium hydrogen exchanger H9401_0784 ENOG4106KNT transcriptional regulator H9401_0791 ENOG4108PCN EamA-like transporter family H9401_0792 ENOG4108YXU transcriptional regulator AsnC family H9401_0794 ENOG4105KPY Small multidrug resistance protein H9401_0795 ENOG4105KPY Small multidrug resistance protein H9401_0800 ENOG4105NF4 modulator of drug activity H9401_0801 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) H9401_0802 ENOG4105E5W Transporter H9401_0805 ENOG4107RKG DJ-1/PfpI family H9401_0806 ENOG4105CH6 catalase H9401_0808 ENOG4105D5Q Arginine ornithine antiporter H9401_0809 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) H9401_0811 ENOG4105C26 Dehydrogenase H9401_0812 ENOG4105BZ1 (ABC) transporter H9401_0813 ENOG4105BZ1 (ABC) transporter H9401_0814 ENOG4105BZ1 (ABC) transporter H9401_0816 ENOG4105DRP amino acid AbC transporter H9401_0817 ENOG4105CDA abc transporter atp-binding protein H9401_0819 ENOG410839P H9401_0826 ENOG4107FQX Alpha-acetolactate decarboxylase H9401_0831 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase H9401_0833 ENOG4105D4P Coproporphyrinogen iii oxidase H9401_0836 ENOG4105CHH sulfate transporter H9401_0844 ENOG4106AKK s-layer domain-containing protein H9401_0846 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein H9401_0847 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein H9401_0850 ENOG4105CGU Enoyl-CoA hydratase H9401_0853 ENOG4105DER m42 family H9401_0857 ENOG4105CTU Proline racemase H9401_0868 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H9401_0871 ENOG4108JQ7 (ABC) transporter H9401_0877 ENOG4105CSH Transporter H9401_0879 ENOG4108MRH transcriptional regulatory protein H9401_0888 ENOG4105CDU Replicative dna helicase H9401_0895 ENOG4105C0R drug resistance transporter emrb qaca subfamily H9401_0904 ENOG4107P5I polyketide synthase H9401_0905 ENOG4108IG5 Transcriptional regulator H9401_0909 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase H9401_0913 ENOG4105CMT Dihydroxyacetone kinase H9401_0915 ENOG4105CMT Dihydroxyacetone kinase H9401_0916 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) H9401_0917 ENOG410847I Transcriptional regulator, BadM Rrf2 family H9401_0924 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase H9401_0936 ENOG4105WN5 stage II sporulation protein H9401_0938 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H9401_0940 ENOG4108MJI response regulator H9401_0941 ENOG4105BZU Histidine kinase H9401_0942 ENOG4105BZU Histidine kinase H9401_0947 ENOG4105K8R UPF0145 protein H9401_0954 ENOG4107VRP DNA repair exonuclease H9401_0955 ENOG4106D4I domain protein H9401_0956 ENOG4105D7V transposase H9401_0959 ENOG4108IND Tetr family transcriptional regulator H9401_0960 ENOG4105EQ0 Major Facilitator superfamily H9401_0965 ENOG4108MUZ hydrolase H9401_0970 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator H9401_0973 ENOG4105C6V Glycerol-3-phosphate dehydrogenase H9401_0976 ENOG4105EMN RNA polymerase sigma factor H9401_0981 ENOG4105C57 major facilitator superfamily H9401_0982 ENOG4105C0R drug resistance transporter emrb qaca subfamily H9401_0984 ENOG4105EEM helicase H9401_0985 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) H9401_0990 ENOG4105K59 histidine triad (HIT) protein H9401_0997 ENOG410905X membrane-flanked domain protein H9401_0999 ENOG4105CKV Membrane H9401_1007 ENOG410905X membrane-flanked domain protein H9401_1008 ENOG4105CKV Membrane H9401_1009 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation H9401_1010 ENOG4105BZ4 penicillin-binding protein H9401_1011 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) H9401_1013 ENOG4105C1Q protoporphyrinogen oxidase H9401_1018 ENOG4105NA0 Transcriptional regulator H9401_1021 ENOG4105ECB domain protein H9401_1027 ENOG4106AXD H9401_1028 ENOG4108RQ5 Beta-lactamase domain-containing protein H9401_1029 ENOG4105DF9 Lipoate-protein, ligase H9401_1031 ENOG4105CEY Amp-dependent synthetase and ligase H9401_1034 ENOG4105CNA YD repeat protein H9401_1038 ENOG4105CNA YD repeat protein H9401_1046 ENOG4105ENX hydrolase H9401_1048 ENOG4107RN3 metallophosphoesterase H9401_1049 ENOG4107TVP HD domain protein H9401_1051 ENOG4108AEY RNA polymerase sigma factor H9401_1052 ENOG41086D8 Transcriptional regulator H9401_1055 ENOG4105DPZ Two component transcriptional regulator (Winged helix family H9401_1060 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 H9401_1061 ENOG4105C8Q Methyl-accepting chemotaxis H9401_1066 ENOG4105ZU5 s-layer protein H9401_1067 ENOG4107QP3 malate synthase g H9401_1070 ENOG4105VEQ Cold shock protein H9401_1073 ENOG4105XVF Competence transcription factor H9401_1076 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination H9401_1077 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation H9401_1086 ENOG4105ERH Fumarylacetoacetate hydrolase H9401_1091 ENOG4105CAQ asparagine synthetase H9401_1092 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) H9401_1093 ENOG4105CH6 catalase H9401_1094 ENOG4105BZU Histidine kinase H9401_1098 ENOG4105QNR S1 RNA binding domain protein H9401_1100 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) H9401_1102 ENOG4107AYK membrAne H9401_1103 ENOG41073B9 H9401_1105 ENOG4108KP7 hydrolase H9401_1108 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H9401_1113 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H9401_1114 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H9401_1117 ENOG4105C31 Tryptophanyl-tRNA synthetase H9401_1120 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H9401_1121 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H9401_1123 ENOG4108JQ7 (ABC) transporter H9401_1124 ENOG4105UQX Mate efflux family protein H9401_1129 ENOG4108ZCF integral membrane protein H9401_1131 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) H9401_1133 ENOG4105DPN Oligoendopeptidase f H9401_1136 ENOG4108Z18 K06886 hemoglobin H9401_1137 ENOG4105MIX Adenylate cyclase H9401_1140 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) H9401_1141 ENOG4105EMS pseudouridine synthase H9401_1144 ENOG4105CNI cell division protein FtsW H9401_1146 ENOG4105K64 Glycosyl transferase, family 2 H9401_1150 ENOG4107TVC Glycosyl transferase, family 2 H9401_1154 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) H9401_1155 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase H9401_1157 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase H9401_1167 ENOG4108WVJ 2'-5' rna ligase H9401_1172 ENOG4105CK7 Sodium proline symporter H9401_1173 ENOG4105CRQ synthase (Component I) H9401_1174 ENOG4105DDQ anthranilate synthase H9401_1192 ENOG4105C7S Dehydrogenase H9401_1194 ENOG4105VZ8 Transcriptional regulator H9401_1202 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) H9401_1204 ENOG4105DZ1 carboxypeptidase H9401_1205 ENOG4105VFR signal peptidase H9401_1211 ENOG4105C26 Dehydrogenase H9401_1212 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H9401_1213 ENOG4105F38 ABC transporter, permease H9401_1214 ENOG4105D38 putrescine abc transporter H9401_1215 ENOG4107RUE extracellular solute-binding protein family 1 H9401_1217 ENOG4105EYF MMPL domain protein H9401_1219 ENOG4108YBP pseudouridine synthase H9401_1220 ENOG4108YBP pseudouridine synthase H9401_1222 ENOG4105K4I Scp-like extracellular H9401_1223 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H9401_1224 ENOG4105CQB FAD linked oxidase domain protein H9401_1227 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H9401_1228 ENOG4105BZU Histidine kinase H9401_1229 ENOG4105JXH GntR family transcriptional regulator H9401_1233 ENOG4106A3R peptidase H9401_1236 ENOG4108QTI )-transporter H9401_1237 ENOG4107TS3 membrane protein, TerC H9401_1238 ENOG4105CZN Potassium uptake protein H9401_1239 ENOG410681C small acid-soluble spore protein H9401_1240 ENOG4108Z7G MaoC domain protein dehydratase H9401_1244 ENOG4105CHR reductase H9401_1246 ENOG4105MWK D-amino acid dehydrogenase, small subunit H9401_1250 ENOG4105C4Y ABC transporter H9401_1251 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H9401_1253 ENOG4107RCV ABC transporter, permease H9401_1254 ENOG4108KAZ Involved in phosphonate degradation (By similarity) H9401_1257 ENOG4105E98 transcriptional regulator DeoR family H9401_1262 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) H9401_1263 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) H9401_1265 ENOG4105PXI polysaccharide deacetylase H9401_1267 ENOG4105BZU Histidine kinase H9401_1268 ENOG41090MY MarR family Transcriptional regulator H9401_1270 ENOG4106DF1 H9401_1272 ENOG4105BZU Histidine kinase H9401_1274 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase H9401_1275 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) H9401_1283 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) H9401_1284 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H9401_1286 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H9401_1287 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H9401_1288 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family H9401_1289 ENOG4105CZV ABC transporter H9401_1291 ENOG4105CJ1 ABC, transporter H9401_1299 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A H9401_1300 ENOG4105EA8 2-Nitropropane dioxygenase H9401_1301 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD H9401_1303 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein H9401_1308 ENOG4105NQC Flavodoxin H9401_1315 ENOG4107QMU Mate efflux family protein H9401_1316 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) H9401_1322 ENOG4105CZN Potassium uptake protein H9401_1323 ENOG41063Y9 H9401_1324 ENOG4105KBJ sporulation protein ytfj H9401_1328 ENOG4105CM2 brancheD-chain amino acid aminotransferase H9401_1329 ENOG4105C7K acetolactate synthase H9401_1330 ENOG4108ZP8 Acetolactate synthase small subunit H9401_1331 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase H9401_1333 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H9401_1338 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) H9401_1345 ENOG4107RVV histidinol phosphate phosphatase, hisj family H9401_1348 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase H9401_1349 ENOG4105E0M Sulfatase H9401_1351 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) H9401_1356 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) H9401_1357 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) H9401_1359 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) H9401_1360 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein H9401_1361 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein H9401_1362 ENOG4105C8J )-transporter H9401_1366 ENOG4105DFD Na H antiporter H9401_1370 ENOG4105ENE Histidine kinase H9401_1371 ENOG4105WH1 Two component transcriptional regulator luxr family H9401_1374 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) H9401_1379 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H9401_1383 ENOG4105CJ3 phosphate transporter H9401_1384 ENOG4107GRR phosphate transport regulator H9401_1385 ENOG4105BZ4 penicillin-binding protein H9401_1387 ENOG4105BZU Histidine kinase H9401_1388 ENOG4105I3N Conserved Protein H9401_1391 ENOG4105BZU Histidine kinase H9401_1398 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H9401_1399 ENOG4105DZ1 carboxypeptidase H9401_1400 ENOG4108JIC nucleoside recognition domain protein H9401_1402 ENOG4105FE9 pseudouridine synthase H9401_1404 ENOG4107TWT Cytochrome c biogenesis protein H9401_1405 ENOG4105CRE cytochrome C H9401_1406 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H9401_1407 ENOG4105BZU Histidine kinase H9401_1408 ENOG4108WBT adenosyltransferase H9401_1411 ENOG4108SAX Membrane H9401_1413 ENOG4105T7X H9401_1414 ENOG4105C9U ATP-dependent DNA helicase RecQ H9401_1415 ENOG4105I7S Abortive infection protein H9401_1417 ENOG4107RGJ metallophosphoesterase H9401_1418 ENOG4107RGJ metallophosphoesterase H9401_1419 ENOG4107X2D transcriptional regulator, merr family H9401_1420 ENOG4108S6Z Negative regulator of genetic competence H9401_1425 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase H9401_1426 ENOG4105HDK L-asparaginase H9401_1432 ENOG4105S2F H9401_1433 ENOG41065D1 H9401_1439 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) H9401_1442 ENOG4105XXQ heptaprenyl diphosphate synthase component I H9401_1444 ENOG4105EAH synthase H9401_1448 ENOG4105CIH Imidazole acetol-phosphate transaminase H9401_1449 ENOG41068YB TPR repeat-containing protein H9401_1452 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) H9401_1453 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) H9401_1454 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit H9401_1460 ENOG4108JYZ YitT family H9401_1461 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase H9401_1464 ENOG4105FJR Lmbe family H9401_1465 ENOG4105CPK Glycosyl transferase (Group 1 H9401_1472 ENOG4105DVT helicase H9401_1473 ENOG4105YAC H9401_1477 ENOG4105CSM endonuclease III H9401_1479 ENOG4105BZ4 penicillin-binding protein H9401_1490 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) H9401_1492 ENOG4105DVT helicase H9401_1493 ENOG4105CTD carboxy-peptidase H9401_1496 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) H9401_1499 ENOG4105C2W permease H9401_1500 ENOG4105DHF Membrane H9401_1502 ENOG410890F Dynamin family H9401_1504 ENOG4108W0I acetyltransferase H9401_1506 ENOG4105KHC sulfurtransferase H9401_1509 ENOG4106032 Glutathionylspermidine synthase H9401_1522 ENOG4105CPK Glycosyl transferase (Group 1 H9401_1525 ENOG4108SZE gCN5-related N-acetyltransferase H9401_1529 ENOG41081VK Ribonuclease H9401_1542 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H9401_1544 ENOG4107RWR Sodium hydrogen exchanger H9401_1545 ENOG4105CN5 Metallo-Beta-Lactamase H9401_1546 ENOG4108Z5V transcriptional regulator, merr family H9401_1548 ENOG4105H67 Protein of unknown function (DUF421) H9401_1550 ENOG41080C8 DUF218 domain H9401_1561 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) H9401_1563 ENOG4107R0U MotA TolQ exbB proton channel H9401_1564 ENOG4105ER2 Ompa motb domain protein H9401_1565 ENOG4107YTP response regulator receiver protein H9401_1566 ENOG4105CBS Chea signal transduction histidine kinase H9401_1567 ENOG4105CBS Chea signal transduction histidine kinase H9401_1568 ENOG4105DD5 Flagellar motor switch protein H9401_1571 ENOG4105BZU Histidine kinase H9401_1575 ENOG4105E1Q flagellar hook-associated protein H9401_1576 ENOG4105DTJ flagellar hook-associated protein H9401_1581 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) H9401_1582 ENOG4108ZC9 flagellar basal-body rod protein flgc H9401_1583 ENOG41075Z6 flagellar hook-basal body complex protein fliE H9401_1584 ENOG4107U2N Flagellar M-ring protein H9401_1586 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) H9401_1594 ENOG4105BZE flagellar hook protein, FlgE H9401_1598 ENOG4107R88 Chemotaxis protein (CheV) H9401_1600 ENOG4105K64 Glycosyl transferase, family 2 H9401_1607 ENOG4107TVC Glycosyl transferase, family 2 H9401_1612 ENOG4105I03 Flagellin H9401_1613 ENOG4105E4C Lytic transglycosylase catalytic H9401_1615 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) H9401_1617 ENOG4105DD5 Flagellar motor switch protein H9401_1619 ENOG4105CN7 Flagellar biosynthetic protein FliP H9401_1620 ENOG4105VS8 Flagellar biosynthetic protein fliq H9401_1622 ENOG4105D00 flagellar biosynthetic protein flhB H9401_1623 ENOG4105D7B Flagellar biosynthesis protein flha H9401_1624 ENOG4105FZW flagellar biosynthesis regulator FlhF H9401_1625 ENOG4105KTQ flagellar basal-body rod protein H9401_1626 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H9401_1631 ENOG4108RZE Tetr family transcriptional regulator H9401_1634 ENOG4105KAC Antibiotic biosynthesis monooxygenase H9401_1639 ENOG4105DUM transcriptional regulator, lysR family H9401_1640 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H9401_1641 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein H9401_1642 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component H9401_1643 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) H9401_1650 ENOG4105CVJ phosphoglycerate mutase H9401_1657 ENOG4105CAQ asparagine synthetase H9401_1661 ENOG4105PGM cation diffusion facilitator family transporter H9401_1663 ENOG4105DRR Transcriptional regulator, GntR family H9401_1664 ENOG4108UZ3 Transporter H9401_1665 ENOG4105CKI cobalamin synthesis protein H9401_1666 ENOG4108PJD permease H9401_1669 ENOG4105DFD Na H antiporter H9401_1670 ENOG4105C9Q fumarate hydratase class II H9401_1674 ENOG4107QJQ Mate efflux family protein H9401_1675 ENOG4107QJQ Mate efflux family protein H9401_1676 ENOG4105EC3 peptidase S51, dipeptidase E H9401_1680 ENOG4107QIV Cytochrome c biogenesis protein H9401_1687 ENOG4106BRA Membrane H9401_1694 ENOG4105CJ1 ABC, transporter H9401_1698 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) H9401_1700 ENOG4108IJ0 Aspartate ammonia-lyase H9401_1701 ENOG4105C6K Malic enzyme H9401_1714 ENOG4105FVX H9401_1722 ENOG4105CSR polyphosphate kinase 2 H9401_1723 ENOG4105DXI Major Facilitator superfamily H9401_1724 ENOG4105DXI Major Facilitator superfamily H9401_1727 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) H9401_1730 ENOG4105EU0 Major facilitator Superfamily H9401_1731 ENOG4105C6T cysteine synthase H9401_1735 ENOG4105C8J )-transporter H9401_1737 ENOG4105X5K response regulator receiver protein H9401_1738 ENOG4105H67 Protein of unknown function (DUF421) H9401_1742 ENOG4106KE4 Dehydrogenase H9401_1745 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) H9401_1746 ENOG4105CHR reductase H9401_1747 ENOG4105CM2 brancheD-chain amino acid aminotransferase H9401_1748 ENOG4105C7K acetolactate synthase H9401_1749 ENOG4108ZP8 Acetolactate synthase small subunit H9401_1750 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase H9401_1752 ENOG4105C7B Threonine dehydratase H9401_1756 ENOG4105C6X Major Facilitator H9401_1757 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b H9401_1759 ENOG4105DY9 regulatoR H9401_1760 ENOG4105CYC Transferase H9401_1764 ENOG4105F6J Alpha beta hydrolase fold H9401_1765 ENOG4108J59 Extracellular solute-binding protein, family 5 H9401_1772 ENOG41068WN H9401_1777 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) H9401_1778 ENOG4105C72 UPF0176 protein H9401_1780 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) H9401_1782 ENOG4105C0X amino acid H9401_1783 ENOG4105C0X amino acid H9401_1788 ENOG4107RHR regulatoR H9401_1790 ENOG4105D9N nucleoside H9401_1791 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) H9401_1798 ENOG4107RAQ aminopeptidase H9401_1799 ENOG4107STQ Multicopper oxidase H9401_1810 ENOG4108T5E Copper resistance protein H9401_1811 ENOG4105KTB nuclear export factor GLE1 H9401_1813 ENOG4107RT3 EamA-like transporter family H9401_1814 ENOG4105GZI Transcriptional regulator H9401_1815 ENOG4108Z40 Transcriptional regulator H9401_1816 ENOG4107ZXU DSBA oxidoreductase H9401_1817 ENOG4108TVJ Nitroreductase H9401_1819 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) H9401_1820 ENOG4106F5Q Membrane H9401_1821 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) H9401_1823 ENOG4105CKI cobalamin synthesis protein H9401_1827 ENOG4108Z7G MaoC domain protein dehydratase H9401_1828 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H9401_1830 ENOG4105C0Z ABC transporter H9401_1831 ENOG4108IV0 ABC, transporter H9401_1832 ENOG4105C32 Amino acid ABC transporter (Permease) H9401_1834 ENOG4105SKE transcriptional Regulator LysR family H9401_1836 ENOG4105MDS 4-oxalocrotonate tautomerase H9401_1838 ENOG4105YGB Transcriptional regulator H9401_1840 ENOG4105C4M (Ubiquinol oxidase) subunit I H9401_1841 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H9401_1842 ENOG4108JJ9 ABC, transporter H9401_1843 ENOG4108JJ8 (ABC) transporter H9401_1851 ENOG4105BZ1 (ABC) transporter H9401_1852 ENOG4105BZ1 (ABC) transporter H9401_1853 ENOG4105EFI regulatoR H9401_1854 ENOG4105BZU Histidine kinase H9401_1858 ENOG41075D4 Aminoglycoside 6-adenylyltransferase H9401_1859 ENOG4108ZJ4 polysaccharide deacetylase H9401_1865 ENOG4105D6E homoserine dehydrogenase H9401_1870 ENOG4108KGH TRANSCRIPTIONal H9401_1872 ENOG4105DPZ Two component transcriptional regulator (Winged helix family H9401_1873 ENOG4105BZU Histidine kinase H9401_1874 ENOG4107VMI polysaccharide deacetylase H9401_1876 ENOG4105KT7 mgtC SapB transporter H9401_1877 ENOG4105VRR gCN5-related N-acetyltransferase H9401_1879 ENOG4105DUU IucA IucC family protein H9401_1880 ENOG4105CEY Amp-dependent synthetase and ligase H9401_1883 ENOG4108WBH protein TIM barrel H9401_1884 ENOG4105YWU small acid-soluble spore protein H9401_1886 ENOG4107RCC Major Facilitator Superfamily H9401_1888 ENOG4108ZUB Lysine exporter protein (Lyse ygga) H9401_1899 ENOG4105KRN Transcriptional regulator, abrb family H9401_1901 ENOG4105YVS arsR family transcriptional regulator H9401_1902 ENOG4107SET aldo keto reductase H9401_1903 ENOG4107XZQ multidrug resistance protein H9401_1908 ENOG4105C8Q Methyl-accepting chemotaxis H9401_1911 ENOG4108K88 Membrane H9401_1912 ENOG4108WPJ Ferritin-like domain H9401_1915 ENOG4105DEN Luciferase family H9401_1919 ENOG4107QM2 Aldo Keto reductase H9401_1920 ENOG4105CKI cobalamin synthesis protein H9401_1930 ENOG4105DSE periplasmic solute binding protein H9401_1932 ENOG4105K4T epimerase H9401_1934 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H9401_1939 ENOG4105CVJ phosphoglycerate mutase H9401_1943 ENOG4107T5V SNARE associated Golgi H9401_1946 ENOG4108PJD permease H9401_1948 ENOG4108S4H thioesterase Superfamily protein H9401_1949 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) H9401_1954 ENOG4105SXS Protein of unknown function (DUF456) H9401_1955 ENOG4105C37 (CBS) domain H9401_1959 ENOG4108Z7R Chaperone CsaA H9401_1962 ENOG4108ZRV stage ii sporulation protein p H9401_1964 ENOG4108VXD carboxy-peptidase H9401_1966 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) H9401_1971 ENOG4108X4Q Hydrolase H9401_1973 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H9401_1974 ENOG4107RBS Methyltransferase H9401_1977 ENOG41087PP glycosyltransferase MGT family H9401_1978 ENOG4108JYZ YitT family H9401_1979 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H9401_1986 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) H9401_1994 ENOG4105KBJ sporulation protein ytfj H9401_1999 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H9401_2003 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) H9401_2004 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase H9401_2006 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H9401_2007 ENOG4105EMN RNA polymerase sigma factor H9401_2012 ENOG4108V06 Glutathione peroxidase H9401_2015 ENOG4105C7R Atpase associated with various cellular activities aaa_3 H9401_2019 ENOG4108IUE nitrate reductase beta subunit H9401_2020 ENOG4105R3A Nitrate reductase H9401_2025 ENOG4107V6Q Cyclic nucleotide-binding domain H9401_2026 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H9401_2027 ENOG4105D06 uba thif-type nad fad binding protein H9401_2028 ENOG4105CVM Molybdenum cofactor synthesis domain protein H9401_2029 ENOG4108ZAF Molybdopterin H9401_2034 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein H9401_2035 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein H9401_2036 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) H9401_2037 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit H9401_2038 ENOG4108IFG nitrite reductase, (NAD(P)H) H9401_2039 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) H9401_2046 ENOG4105MCT stage V sporulation protein S H9401_2048 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase H9401_2052 ENOG4105C5H ABC transporter H9401_2055 ENOG4108UUM single-stranded DNA-binding protein H9401_2058 ENOG41061H0 Monooxygenase H9401_2062 ENOG4107YX5 Pfam:DUF548 H9401_2063 ENOG4105C75 arginyL-tRNA synthetase H9401_2068 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) H9401_2071 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) H9401_2072 ENOG4105C5S asparaginyl-tRNA synthetase H9401_2076 ENOG4105EC2 ftsk spoIIIe H9401_2095 ENOG4105BZW Glycerate kinase H9401_2096 ENOG4107QPK )-transporter H9401_2097 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H9401_2098 ENOG41062D9 Histidine kinase H9401_2101 ENOG4105C8J )-transporter H9401_2105 ENOG4107XGZ Hydrolase H9401_2106 ENOG4105CY2 Citrate transporter H9401_2107 ENOG4105C0A alcohol dehydrogenase H9401_2110 ENOG4105KD7 acetyltransferase H9401_2112 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase H9401_2118 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 H9401_2122 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) H9401_2125 ENOG4107RVG penicillin-binding protein H9401_2126 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) H9401_2127 ENOG4105E9Q Acyl-transferase H9401_2128 ENOG4108UT2 hemolysin iii H9401_2130 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) H9401_2132 ENOG4108RCR degv family H9401_2133 ENOG4105E8R UPF0173 metal-dependent hydrolase H9401_2135 ENOG4108KF3 Electron transport protein SCO1 SenC H9401_2136 ENOG4107Y70 Heat shock protein H9401_2137 ENOG4105CAQ asparagine synthetase H9401_2140 ENOG4108MES Periplasmic binding protein H9401_2141 ENOG4105F0I Aminotransferase H9401_2148 ENOG4105D8X mechanosensitive ion channel H9401_2149 ENOG4105BZU Histidine kinase H9401_2150 ENOG4105WH1 Two component transcriptional regulator luxr family H9401_2152 ENOG4106KNT transcriptional regulator H9401_2160 ENOG4105CMG Carbohydrate kinase H9401_2161 ENOG4105CMG Carbohydrate kinase H9401_2167 ENOG4108IJ8 ABC transporter H9401_2168 ENOG4105E90 ABC transporter H9401_2175 ENOG4105C37 (CBS) domain H9401_2181 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H9401_2184 ENOG4107S4Y M20 DapE family protein YgeY H9401_2185 ENOG4108TSC N-acetyltransferase H9401_2186 ENOG4108JUB Transcriptional regulator H9401_2187 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein H9401_2195 ENOG4108N23 SpoOM-related protein H9401_2196 ENOG410841Q phosphoesterase PA-phosphatase related protein H9401_2198 ENOG4105SZ6 Thioredoxin H9401_2201 ENOG4108IBT Inherit from COG: transposase H9401_2218 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) H9401_2225 ENOG4105BZ4 penicillin-binding protein H9401_2226 ENOG4105CZM Major Facilitator H9401_2227 ENOG4105W8X HesB YadR YfhF-family protein H9401_2229 ENOG4105DXD 2-methylcitrate dehydratase H9401_2230 ENOG4105CR4 methylisocitrate lyase H9401_2232 ENOG4105C1G acyl-Coa dehydrogenase H9401_2233 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H9401_2235 ENOG4105N14 lysine exporter protein LysE YggA H9401_2236 ENOG4105E39 Enoyl-CoA hydratase H9401_2239 ENOG4107RFY SbcCD D subunit H9401_2240 ENOG4105EYH Exonuclease H9401_2246 ENOG4105FCD Major Facilitator H9401_2247 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase H9401_2248 ENOG4105E4F Isochorismate synthase H9401_2249 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase H9401_2250 ENOG4105WQI isochorismatase H9401_2251 ENOG4105CEY Amp-dependent synthetase and ligase H9401_2252 ENOG4105WQT MbtH domain protein H9401_2253 ENOG4105C0R drug resistance transporter emrb qaca subfamily H9401_2256 ENOG4105K70 DNA-binding protein H9401_2261 ENOG4105BZG amino acid carrier protein H9401_2265 ENOG4105FE9 pseudouridine synthase H9401_2267 ENOG4105C22 threonyL-tRNA synthetase H9401_2268 ENOG4105C19 ABC transporter H9401_2271 ENOG4107SKW Inherit from COG: Alpha beta hydrolase H9401_2277 ENOG4108D32 Methyltransferase H9401_2283 ENOG41081I9 integral membrane protein H9401_2285 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) H9401_2287 ENOG4105EYF MMPL domain protein H9401_2292 ENOG4105WCN acetyltransferase H9401_2298 ENOG4105C1Q protoporphyrinogen oxidase H9401_2300 ENOG41068WN H9401_2302 ENOG4105VEQ Cold shock protein H9401_2306 ENOG410667J hydrolase H9401_2313 ENOG4107V2S Transcriptional regulator H9401_2314 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H9401_2317 ENOG4105DND Transcriptional regulator H9401_2318 ENOG4108RPX mosc domain containing protein H9401_2321 ENOG4105BZ1 (ABC) transporter H9401_2322 ENOG4105BZ1 (ABC) transporter H9401_2325 ENOG4108JCI Transcriptional regulator H9401_2331 ENOG4108KPJ rna polymerase sigma factor H9401_2337 ENOG4105F32 YngK protein H9401_2343 ENOG4105RD7 BadF BadG BcrA BcrD H9401_2345 ENOG4107STF Involved in phosphonate degradation (By similarity) H9401_2348 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) H9401_2351 ENOG4105C1J atp-dependent rna helicase H9401_2355 ENOG4108RZE Tetr family transcriptional regulator H9401_2359 ENOG41088CC tellurite resistance protein tehB H9401_2361 ENOG4108I0C methyltransferase H9401_2362 ENOG4107RA9 decarboxylase H9401_2363 ENOG41090HR transcriptional regulator H9401_2373 ENOG4105CIN aminoacyl-histidine dipeptidase H9401_2379 ENOG4107RF6 penicillin-binding protein H9401_2380 ENOG4107RF6 penicillin-binding protein H9401_2381 ENOG4107RF6 penicillin-binding protein H9401_2383 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H9401_2384 ENOG4105ETE Transcriptional regulator (LacI family H9401_2385 ENOG4105IE8 Alpha-ketoglutarate permease H9401_2386 ENOG4105CK5 oxidoreductase H9401_2391 ENOG4105D2N Aldolase H9401_2392 ENOG4105DH8 myo-inositol catabolism H9401_2396 ENOG4105CGH 5'-nucleotidase H9401_2397 ENOG4105CGH 5'-nucleotidase H9401_2400 ENOG4105VZ8 Transcriptional regulator H9401_2402 ENOG4108VXD carboxy-peptidase H9401_2406 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity H9401_2407 ENOG41067SE Tetr family transcriptional regulator H9401_2408 ENOG4105C5H ABC transporter H9401_2410 ENOG4105BZU Histidine kinase H9401_2413 ENOG4106ANW SMI1_KNR4 H9401_2414 ENOG4105CEP NADH dehydrogenase H9401_2415 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) H9401_2418 ENOG4105CJ1 ABC, transporter H9401_2420 ENOG4107Z3H Transcriptional regulator, TetR family H9401_2423 ENOG4105C1G acyl-Coa dehydrogenase H9401_2424 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H9401_2425 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit H9401_2426 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase H9401_2427 ENOG4105E39 Enoyl-CoA hydratase H9401_2428 ENOG4107QX3 carboxylase H9401_2429 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H9401_2431 ENOG4105WCN acetyltransferase H9401_2432 ENOG4105DBI uridine monophosphokinase H9401_2438 ENOG4105T9C HD domain H9401_2440 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) H9401_2449 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H9401_2452 ENOG4105FQP Beta-lactamase H9401_2454 ENOG4107Y80 Major Facilitator superfamily H9401_2458 ENOG4105CUV Homoserine Kinase H9401_2464 ENOG4105CPQ Dehydrogenase H9401_2467 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) H9401_2468 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) H9401_2488 ENOG4105ETU transcriptional activator (TenA H9401_2509 ENOG410667J hydrolase H9401_2511 ENOG4105BZU Histidine kinase H9401_2512 ENOG4107RF6 penicillin-binding protein H9401_2516 ENOG4108JJB ABC transporter H9401_2519 ENOG4108HGU Histidine kinase H9401_2523 ENOG4105CB2 alcohol dehydrogenase H9401_2524 ENOG4105CJN penicillin-binding protein H9401_2526 ENOG4105FQP Beta-lactamase H9401_2532 ENOG4108V4B ThiJ pfpI H9401_2537 ENOG4107Y80 Major Facilitator superfamily H9401_2540 ENOG4107VXM glycerophosphoryl diester phosphodiesterase H9401_2545 ENOG4107Y9U Membrane H9401_2553 ENOG4105FCD Major Facilitator H9401_2555 ENOG4105E09 nadh pyrophosphatase H9401_2556 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H9401_2557 ENOG4108Z4K mutator MutT protein H9401_2564 ENOG4108XI2 Domain of unknown function (DUF1963) H9401_2570 ENOG4105KWG Pfam:DUF1696 H9401_2577 ENOG4105PKS Excinuclease abc c subunit domain protein H9401_2586 ENOG4107VFR oxidoreductase H9401_2591 ENOG4105PAD Hydrolase H9401_2596 ENOG4105DY8 decarboxylase H9401_2600 ENOG4108IUM Glycogen debranching enzyme H9401_2605 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) H9401_2607 ENOG4105FDR Membrane H9401_2614 ENOG4108V3A UPF0421 protein H9401_2618 ENOG4105MSI germination protein ypeb H9401_2622 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) H9401_2623 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) H9401_2624 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) H9401_2625 ENOG4107Z3H Transcriptional regulator, TetR family H9401_2631 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family H9401_2635 ENOG4105E98 transcriptional regulator DeoR family H9401_2639 ENOG41062ES Transcriptional regulator H9401_2644 ENOG4107QKR Dehydrogenase H9401_2645 ENOG4107QKR Dehydrogenase H9401_2647 ENOG4107RUY (E1 component), alpha subunit H9401_2649 ENOG4105E1F short-chain dehydrogenase reductase H9401_2650 ENOG4105RHY Pfam:UPF0157 H9401_2655 ENOG4107SQ8 Glycine betaine H9401_2656 ENOG4108IJ7 Glycine betaine H9401_2661 ENOG4105E66 phosphoriboisomerase A H9401_2662 ENOG41082BV acetyltransferase H9401_2663 ENOG4108M1A Chitin-binding protein H9401_2673 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 H9401_2679 ENOG4108Z7F N-acetyltransferase H9401_2683 ENOG4105EEM helicase H9401_2687 ENOG4105C9U ATP-dependent DNA helicase RecQ H9401_2696 ENOG4108M1A Chitin-binding protein H9401_2699 ENOG4105BZG amino acid carrier protein H9401_2700 ENOG4105C26 Dehydrogenase H9401_2701 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H9401_2702 ENOG4105CTU Proline racemase H9401_2703 ENOG4105CTU Proline racemase H9401_2704 ENOG41080HI glycine oxidase H9401_2712 ENOG4107T5V SNARE associated Golgi H9401_2715 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD H9401_2716 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) H9401_2719 ENOG4105DTQ mandelate racemase muconate lactonizing H9401_2728 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) H9401_2729 ENOG4105BZU Histidine kinase H9401_2730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H9401_2731 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H9401_2738 ENOG4105DPN Oligoendopeptidase f H9401_2741 ENOG4105EPR degv family H9401_2749 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) H9401_2750 ENOG4106K7D Major facilitator family transporter H9401_2755 ENOG4107BMA Transglycosylase associated protein H9401_2759 ENOG41089UC methyltransferase, type 11 H9401_2766 ENOG4105CHM Aminotransferase H9401_2772 ENOG4105DVE abc transporter atp-binding protein H9401_2780 ENOG4105C02 permease H9401_2782 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) H9401_2783 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component H9401_2784 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein H9401_2789 ENOG4105E09 nadh pyrophosphatase H9401_2793 ENOG4108AQF aminoglycoside N(3)-acetyltransferase H9401_2803 ENOG4107VC0 DNA alkylation repair enzyme H9401_2806 ENOG4107VMI polysaccharide deacetylase H9401_2808 ENOG4108ZCF integral membrane protein H9401_2809 ENOG4105E0M Sulfatase H9401_2810 ENOG4105C5H ABC transporter H9401_2812 ENOG4105EYF MMPL domain protein H9401_2813 ENOG4105EYF MMPL domain protein H9401_2814 ENOG4105EYF MMPL domain protein H9401_2815 ENOG41082JN Transcriptional regulator H9401_2819 ENOG4105CIH Imidazole acetol-phosphate transaminase H9401_2820 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase H9401_2821 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase H9401_2830 ENOG41069ER domain protein H9401_2832 ENOG4105EMN RNA polymerase sigma factor H9401_2837 ENOG4105D4B ABC, transporter H9401_2839 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane H9401_2841 ENOG4105DKT Transcriptional regulator H9401_2842 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) H9401_2845 ENOG41061GT Aldolase H9401_2849 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) H9401_2855 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) H9401_2857 ENOG4105II7 pyrroline-5-carboxylate reductase H9401_2859 ENOG4107258 Transcriptional regulator H9401_2861 ENOG4105E0Y RtcB Protein H9401_2862 ENOG4105ECK Fatty Acid Desaturase H9401_2863 ENOG4105G6Z alkaline phosphatase H9401_2865 ENOG4105VMP Transcriptional regulator H9401_2868 ENOG41090T1 Membrane H9401_2870 ENOG4108WCX response regulator H9401_2872 ENOG41068WN H9401_2878 ENOG4105C7R Atpase associated with various cellular activities aaa_3 H9401_2883 ENOG4105CKK Glycosyl transferase, family 2 H9401_2887 ENOG4105CKK Glycosyl transferase, family 2 H9401_2889 ENOG4105C8Y Acetylornithine aminotransferase H9401_2898 ENOG4105C7R Atpase associated with various cellular activities aaa_3 H9401_2900 ENOG4108TVJ Nitroreductase H9401_2901 ENOG4105FS7 Transcriptional regulator H9401_2910 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family H9401_2912 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H9401_2918 ENOG4108XET gCN5-related N-acetyltransferase H9401_2934 ENOG410635A Membrane H9401_2935 ENOG4105KNA -acetyltransferase H9401_2936 ENOG4108IQI permease H9401_2938 ENOG4105F1N DNA alkylation repair H9401_2946 ENOG4107RF6 penicillin-binding protein H9401_2948 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) H9401_2955 ENOG4105P4J Allophanate hydrolase, subunit 1 H9401_2956 ENOG4107258 Transcriptional regulator H9401_2958 ENOG4106N3A copper homeostasis protein cutc H9401_2959 ENOG4108ZRV stage ii sporulation protein p H9401_2960 ENOG4108ZHR arsR family transcriptional regulator H9401_2962 ENOG4105FDT acyl-CoA dehydrogenase H9401_2966 ENOG4105DWD nucleoside recognition domain protein H9401_2972 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) H9401_2986 ENOG4105E2A Dehydrogenase H9401_2989 ENOG4108IJ0 Aspartate ammonia-lyase H9401_2990 ENOG4105HDK L-asparaginase H9401_2991 ENOG4108IMY Transcriptional regulator H9401_2993 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) H9401_2994 ENOG4105CUB amino acid H9401_2996 ENOG4105II7 pyrroline-5-carboxylate reductase H9401_2999 ENOG4105C6K Malic enzyme H9401_3002 ENOG4108NHD germination protein H9401_3003 ENOG4108NHD germination protein H9401_3004 ENOG4108Q8B Spore germination protein H9401_3010 ENOG4105CSV Glutaminase H9401_3017 ENOG4105CGH 5'-nucleotidase H9401_3018 ENOG4105CH6 catalase H9401_3020 ENOG4105CHJ isochorismatase hydrolase H9401_3025 ENOG41090MY MarR family Transcriptional regulator H9401_3033 ENOG4108606 TspO/MBR family H9401_3034 ENOG4105CVP deoxyribo-dipyrimidine photolyase H9401_3037 ENOG4108TWJ NADH dehydrogenase subunit 5 H9401_3038 ENOG4105GPN Uncharacterized conserved protein (DUF2294) H9401_3040 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase H9401_3041 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) H9401_3042 ENOG4105DSE periplasmic solute binding protein H9401_3043 ENOG4105CC5 ABC transporter H9401_3044 ENOG4105DIK (ABC) transporter H9401_3050 ENOG4105D6J arsenicaL-resistance protein H9401_3051 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase H9401_3052 ENOG41085FC arsR family transcriptional regulator H9401_3055 ENOG4105F7F Chaperone H9401_3057 ENOG4105CHR reductase H9401_3058 ENOG4108YXU transcriptional regulator AsnC family H9401_3072 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) H9401_3073 ENOG4105C0R drug resistance transporter emrb qaca subfamily H9401_3075 ENOG4105IIP Membrane H9401_3078 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H9401_3079 ENOG41062D9 Histidine kinase H9401_3084 ENOG4105K6H D-cysteine desulfhydrase H9401_3088 ENOG4108A04 Beta-lactamase H9401_3090 ENOG4105VZ8 Transcriptional regulator H9401_3093 ENOG4108NNI Beta-lactamase domain-containing protein H9401_3094 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase H9401_3096 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H9401_3097 ENOG4105JQZ Methyltransferase H9401_3100 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H9401_3101 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) H9401_3104 ENOG4105BZU Histidine kinase H9401_3107 ENOG4108U05 Transcriptional regulator H9401_3108 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 H9401_3110 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) H9401_3111 ENOG4105DJB Major Facilitator Superfamily H9401_3112 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) H9401_3113 ENOG4107QR9 Iron-sulfur cluster binding protein H9401_3116 ENOG4106P55 Transcriptional regulator H9401_3118 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A H9401_3124 ENOG4105TRI Hydrolase H9401_3132 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H9401_3139 ENOG4107QJQ Mate efflux family protein H9401_3142 ENOG4105MZU cell filamentation protein H9401_3143 ENOG4105EQ0 Major Facilitator superfamily H9401_3144 ENOG4108JGH Tetr family transcriptional regulator H9401_3146 ENOG4105C44 Serine transporter H9401_3147 ENOG4105EJQ L-serine dehydratase H9401_3150 ENOG4108JPW Aminotransferase H9401_3153 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) H9401_3155 ENOG4105DVH amino acid H9401_3158 ENOG4108JQ1 Dehydrogenase H9401_3162 ENOG4108AEY RNA polymerase sigma factor H9401_3165 ENOG41082W1 Cupin 2, conserved barrel domain protein H9401_3166 ENOG410874W AraC family transcriptional regulator H9401_3170 ENOG4105HIR S-layer domain protein H9401_3179 ENOG4108ISG Major Facilitator H9401_3182 ENOG4105CZM Major Facilitator H9401_3186 ENOG4105DA5 (ABC) transporter H9401_3187 ENOG41069JR H9401_3190 ENOG4105RXJ H9401_3191 ENOG4105KPY Small multidrug resistance protein H9401_3192 ENOG4105KBX Transcriptional regulator, TetR family H9401_3194 ENOG4105CRW Short chain fatty acid transporter H9401_3196 ENOG4105DYS nad(p)h dehydrogenase (quinone) H9401_3202 ENOG4108JJB ABC transporter H9401_3203 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) H9401_3208 ENOG4108K8S endonuclease I H9401_3211 ENOG41067QW Transcriptional regulator H9401_3213 ENOG4108Z66 YbaK ebsC protein H9401_3214 ENOG4105CUT histidyl-tRNA synthetase H9401_3217 ENOG4105KVH Transcriptional regulator H9401_3218 ENOG4108RCM Nitroreductase H9401_3222 ENOG4108PSK reductase H9401_3224 ENOG4105CJ1 ABC, transporter H9401_3236 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase H9401_3237 ENOG4105DKQ ROK family H9401_3238 ENOG4106UW1 Major Facilitator superfamily H9401_3239 ENOG4108UW5 maltose o-acetyltransferase H9401_3241 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H9401_3242 ENOG4105C31 Tryptophanyl-tRNA synthetase H9401_3243 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) H9401_3247 ENOG4105DMQ Methyltransferase H9401_3249 ENOG4105EV4 Multidrug resistance protein mdtH H9401_3255 ENOG4105C37 (CBS) domain H9401_3258 ENOG4105DDN Pentapeptide repeat-containing protein H9401_3259 ENOG4105XDF Protein of unknown function (DUF1272) H9401_3260 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) H9401_3261 ENOG4105CMG Carbohydrate kinase H9401_3262 ENOG4105C6Z Gluconate H9401_3263 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H9401_3266 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase H9401_3267 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase H9401_3268 ENOG4105CIS alcohol dehydrogenase H9401_3269 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone H9401_3272 ENOG4105EWI Short-chain dehydrogenase reductase Sdr H9401_3273 ENOG4105D4Y metalloprotease H9401_3277 ENOG4105CV8 reductase H9401_3278 ENOG4105F27 Major Facilitator H9401_3281 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) H9401_3282 ENOG4105C44 Serine transporter H9401_3288 ENOG4105KVH Transcriptional regulator H9401_3289 ENOG4108TZY GntR Family Transcriptional Regulator H9401_3290 ENOG4105D9R oxidoreductase H9401_3292 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase H9401_3293 ENOG4105KVH Transcriptional regulator H9401_3294 ENOG4105KVH Transcriptional regulator H9401_3301 ENOG4105JAB phenazine biosynthesis protein, phzf family H9401_3303 ENOG4105CHR reductase H9401_3307 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein H9401_3308 ENOG4105KVH Transcriptional regulator H9401_3313 ENOG4108ZJ4 polysaccharide deacetylase H9401_3328 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) H9401_3331 ENOG4107YXZ hydrolase, family 25 H9401_3336 ENOG4105ED2 Beta-lactamase H9401_3338 ENOG4105H3G oxidoreductase H9401_3345 ENOG4105CIS alcohol dehydrogenase H9401_3353 ENOG4108TN2 lmbE family H9401_3355 ENOG4107R3E Citrate transporter H9401_3359 ENOG4108MES Periplasmic binding protein H9401_3361 ENOG4105EHG Permease protein H9401_3362 ENOG4105DQ5 transport system permease protein H9401_3363 ENOG4105NX3 Membrane H9401_3364 ENOG4107ZY0 Phenazine biosynthesis-like protein H9401_3368 ENOG4107CUJ Protein of unknown function (DUF2690) H9401_3370 ENOG4107V2S Transcriptional regulator H9401_3374 ENOG4105C98 muts2 protein H9401_3377 ENOG4105E5K Alpha-amylase H9401_3378 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase H9401_3379 ENOG4105DPN Oligoendopeptidase f H9401_3380 ENOG4108A04 Beta-lactamase H9401_3386 ENOG4107VXM glycerophosphoryl diester phosphodiesterase H9401_3390 ENOG41082BM Transcriptional regulator, arsr family H9401_3391 ENOG4105CIS alcohol dehydrogenase H9401_3397 ENOG4105RHY Pfam:UPF0157 H9401_3398 ENOG4105C09 Bile acid H9401_3399 ENOG4105CQB FAD linked oxidase domain protein H9401_3403 ENOG4108UT6 Transferase hexapeptide repeat containing protein H9401_3405 ENOG4105K64 Glycosyl transferase, family 2 H9401_3406 ENOG4105E39 Enoyl-CoA hydratase H9401_3408 ENOG4105KT7 mgtC SapB transporter H9401_3410 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase H9401_3411 ENOG41073R8 VanW family H9401_3413 ENOG4108R1P H9401_3417 ENOG4105VEQ Cold shock protein H9401_3421 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) H9401_3425 ENOG410904N short-chain dehydrogenase reductase H9401_3427 ENOG4106IQC argininosuccinate lyase H9401_3430 ENOG4108IA2 Sodium pantothenate symporter H9401_3432 ENOG4105C26 Dehydrogenase H9401_3433 ENOG4105CHR reductase H9401_3435 ENOG4105EWU Squalene--hopene cyclase H9401_3437 ENOG4105FR1 rard protein H9401_3438 ENOG410696E Membrane H9401_3441 ENOG4105D1F ATP-binding protein H9401_3443 ENOG4108ZAF Molybdopterin H9401_3444 ENOG4105CVM Molybdenum cofactor synthesis domain protein H9401_3445 ENOG4105D06 uba thif-type nad fad binding protein H9401_3446 ENOG4105TMB Formate nitrite transporter H9401_3448 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) H9401_3449 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) H9401_3450 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) H9401_3452 ENOG4108JB9 formate dehydrogenase H9401_3453 ENOG4105E1K spore germination protein H9401_3466 ENOG4107QJT sodium dicarboxylate symporter H9401_3467 ENOG4108KGH TRANSCRIPTIONal H9401_3469 ENOG4105EMN RNA polymerase sigma factor H9401_3474 ENOG4105CIG ABC transporter H9401_3476 ENOG4105D9R oxidoreductase H9401_3478 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H9401_3479 ENOG4105K4P CoA-binding domain protein H9401_3480 ENOG4105C0H protease H9401_3481 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H9401_3483 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase H9401_3484 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) H9401_3485 ENOG4105W8X HesB YadR YfhF-family protein H9401_3491 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) H9401_3492 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H9401_3494 ENOG4108JJA ABC, transporter H9401_3495 ENOG4108I0Z Aconitate hydratase H9401_3500 ENOG4105E5W Transporter H9401_3502 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H9401_3506 ENOG4107F3J Amp-dependent synthetase and ligase H9401_3507 ENOG4107ZYJ bioY protein H9401_3508 ENOG4105CEY Amp-dependent synthetase and ligase H9401_3517 ENOG4107AYK membrAne H9401_3519 ENOG4105BZU Histidine kinase H9401_3520 ENOG4105FBA Phospholipase Carboxylesterase H9401_3521 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase H9401_3522 ENOG4105CK7 Sodium proline symporter H9401_3523 ENOG4105CBC glutamate synthase H9401_3524 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H9401_3525 ENOG4108VJ1 Transcriptional regulator (CarD family H9401_3526 ENOG4108903 Formimidoylglutamase H9401_3531 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) H9401_3545 ENOG4107QIV Cytochrome c biogenesis protein H9401_3547 ENOG4107RSM transcriptional regulator H9401_3548 ENOG4105VAW lrga family H9401_3549 ENOG41067MG lrgb family H9401_3555 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase H9401_3558 ENOG4105BZ1 (ABC) transporter H9401_3559 ENOG4105BZ1 (ABC) transporter H9401_3563 ENOG4105D7V transposase H9401_3566 ENOG4105D5T phosphonate abc transporter H9401_3569 ENOG4105CGH 5'-nucleotidase H9401_3571 ENOG4108SVB resolvase H9401_3575 ENOG4105K7K Transcriptional regulator H9401_3585 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase H9401_3586 ENOG4105XSJ toxin secretion phage lysis holin H9401_3626 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) H9401_3646 ENOG4105C5F glutamine synthetase H9401_3647 ENOG4105KV4 Transcriptional regulator H9401_3648 ENOG4105CXI aluminum resistance protein H9401_3649 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) H9401_3650 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) H9401_3651 ENOG4105EN6 Membrane H9401_3652 ENOG4106F1P AAA ATPase, central domain protein H9401_3658 ENOG41069ER domain protein H9401_3659 ENOG4105DM4 PTS System H9401_3660 ENOG4105DE4 1-phosphofructokinase H9401_3661 ENOG4105E98 transcriptional regulator DeoR family H9401_3662 ENOG4107QW4 alcohol dehydrogenase H9401_3663 ENOG4107QW4 alcohol dehydrogenase H9401_3664 ENOG4108SJC Membrane H9401_3667 ENOG4105C85 amino acid H9401_3671 ENOG4105TMB Formate nitrite transporter H9401_3672 ENOG4105K70 DNA-binding protein H9401_3673 ENOG4105C59 p-type ATPase H9401_3674 ENOG4105C59 p-type ATPase H9401_3675 ENOG410681U heavy metal transport detoxification protein H9401_3676 ENOG4105VPX protein, conserved in bacteria H9401_3678 ENOG4105NIV Esterase H9401_3679 ENOG4105E0A ABC, transporter H9401_3684 ENOG4105CGK Exodeoxyribonuclease III H9401_3686 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H9401_3687 ENOG4105D03 DNA-3-methyladenine glycosylase II H9401_3694 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase H9401_3695 ENOG4105BZU Histidine kinase H9401_3699 ENOG41067MG lrgb family H9401_3702 ENOG4107TTQ Alpha beta hydrolase fold H9401_3703 ENOG4107YEI lmbE family H9401_3707 ENOG4105F0V Cell wall hydrolase H9401_3708 ENOG4107R6R udp-galactopyranose mutase H9401_3709 ENOG4105E0M Sulfatase H9401_3710 ENOG410890F Dynamin family H9401_3712 ENOG4107QHE Choloylglycine hydrolase H9401_3717 ENOG4105DA5 (ABC) transporter H9401_3722 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) H9401_3723 ENOG4105DQU oxidoreductase, subunit beta H9401_3724 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein H9401_3725 ENOG4108IGT Dipeptidase H9401_3726 ENOG4105MCT stage V sporulation protein S H9401_3727 ENOG4105D48 metallophosphoesterase H9401_3732 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase H9401_3735 ENOG4105XZV Protein of unknown function (DUF3243) H9401_3736 ENOG4108RKS Short-chain dehydrogenase reductase Sdr H9401_3740 ENOG4105UIB (ABC) transporter H9401_3741 ENOG4105UIB (ABC) transporter H9401_3742 ENOG4108JQ9 ABC transporter H9401_3743 ENOG4105DIH basic membrane H9401_3744 ENOG4105FDP GntR family transcriptional regulator H9401_3745 ENOG4107QZI cell division protein FtsK H9401_3747 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit H9401_3749 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H9401_3751 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H9401_3752 ENOG4108S0H Dipicolinic acid synthetase, b subunit H9401_3753 ENOG4105E35 Dipicolinate synthase subunit A H9401_3755 ENOG4105C1V Peptidase, M16 H9401_3758 ENOG4105DTN riboflavin biosynthesis protein ribF H9401_3759 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) H9401_3761 ENOG4105W7A Protein of unknown function (DUF503) H9401_3763 ENOG4105VHM ribosomal protein H9401_3764 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination H9401_3765 ENOG4105CHV Transcription elongation factor NusA H9401_3767 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) H9401_3769 ENOG4105DZP Membrane-associated zinc metalloprotease H9401_3770 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) H9401_3771 ENOG4105KNE Phosphatidate cytidylyltransferase H9401_3772 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) H9401_3780 ENOG4108HE4 integrase family H9401_3782 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H9401_3784 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha H9401_3787 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) H9401_3792 ENOG4105VB6 UPF0109 protein H9401_3796 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) H9401_3797 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) H9401_3800 ENOG4105CHR reductase H9401_3801 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H9401_3804 ENOG4105CB5 ATP-dependent DNA helicase recG H9401_3805 ENOG4105DP4 dak2 domain fusion protein ylov H9401_3806 ENOG4108ZAA Alkaline-shock protein H9401_3808 ENOG4105FJ0 thiamine H9401_3809 ENOG4105DJV ribulose-phosphate 3-epimerase H9401_3810 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) H9401_3811 ENOG4105D9P serine threonine protein kinase H9401_3812 ENOG4108ZF3 Phosphatase H9401_3814 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B H9401_3816 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) H9401_3817 ENOG4105C25 Primosomal protein n' H9401_3818 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase H9401_3822 ENOG4105DSJ YicC domain protein H9401_3824 ENOG4105F23 Fibronectin-binding protein H9401_3825 ENOG4105DC7 peptidase M24 H9401_3837 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain H9401_3842 ENOG4105C34 Pseudouridine synthase H9401_3845 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) H9401_3847 ENOG4105DBK s4 domain protein H9401_3848 ENOG41067XK integral membrane protein H9401_3850 ENOG4105DFA alanine racemase domain protein H9401_3851 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase H9401_3852 ENOG4105WR5 sporulation protein, YlmC YmxH family H9401_3854 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H9401_3856 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) H9401_3857 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) H9401_3858 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) H9401_3859 ENOG4105D4A Cell wall formation (By similarity) H9401_3860 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) H9401_3861 ENOG4105CNI cell division protein FtsW H9401_3864 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) H9401_3865 ENOG4105CJN penicillin-binding protein H9401_3866 ENOG4105CJN penicillin-binding protein H9401_3867 ENOG41068DC Essential cell division protein (By similarity) H9401_3874 ENOG4105KNH Nucleic acid-binding protein H9401_3885 ENOG4105XSJ toxin secretion phage lysis holin H9401_3902 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) H9401_3904 ENOG4105CAR Terminase, large subunit H9401_3921 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) H9401_3923 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H9401_3933 ENOG4108IMY Transcriptional regulator H9401_3940 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) H9401_3942 ENOG41063PX domain protein H9401_3943 ENOG4105D78 K07001 NTE family protein H9401_3944 ENOG4105H20 Sporulation integral membrane protein YlbJ H9401_3946 ENOG4106H78 methyltransferase H9401_3951 ENOG4107TB6 phosphoglycerate mutase H9401_3954 ENOG4106UY4 Inherit from COG: Scp-like extracellular H9401_3964 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) H9401_3965 ENOG4105CNI cell division protein FtsW H9401_3968 ENOG4108IAB Phoh family H9401_3972 ENOG4105QA2 H9401_3973 ENOG4105CI3 gtp-binding protein typa H9401_3975 ENOG4105ECY inositol monophosphatase H9401_3979 ENOG4105CXN decarboxylase H9401_3987 ENOG4105C7S Dehydrogenase H9401_3988 ENOG4105CPP Dehydrogenase, E1 component H9401_3991 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) H9401_3992 ENOG4108X4Q Hydrolase H9401_3994 ENOG4105CN5 Metallo-Beta-Lactamase H9401_3995 ENOG4107ZYR domain protein H9401_4002 ENOG4108XRC Protein of unknown function (DUF458) H9401_4004 ENOG4107IN1 Protein of unknown function (DUF1797) H9401_4008 ENOG4105EPM Diguanylate phosphodiesterase H9401_4009 ENOG4105K6S Short-chain dehydrogenase reductase Sdr H9401_4012 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) H9401_4014 ENOG4105UIN H9401_4025 ENOG4108HGU Histidine kinase H9401_4027 ENOG4105CHM Aminotransferase H9401_4028 ENOG4105FKQ transcriptional regulator H9401_4029 ENOG4105EG2 ABC transporter, permease H9401_4031 ENOG4107FKK extracellular solute-binding protein family 1 H9401_4033 ENOG4105CG3 alpha amylase, catalytic region H9401_4041 ENOG4105CHU acetyl-coa acetyltransferase H9401_4048 ENOG4105K7K Transcriptional regulator H9401_4049 ENOG4105DTD Dehydrogenase H9401_4051 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) H9401_4053 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase H9401_4058 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) H9401_4061 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H9401_4062 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H9401_4063 ENOG4106TD9 Diguanylate cyclase H9401_4067 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H9401_4070 ENOG4105CID antiterminator H9401_4072 ENOG4105FDP GntR family transcriptional regulator H9401_4074 ENOG4105CE4 GlcNAc 6-P deacetylase H9401_4081 ENOG4107ZE5 PPIases accelerate the folding of proteins H9401_4082 ENOG4105PTM secreted protein H9401_4083 ENOG4105J7I hydrolase H9401_4085 ENOG4105G6R Stage v sporulation protein ae H9401_4087 ENOG4105CZ3 stage V sporulation protein ad H9401_4088 ENOG41090VF Stage v sporulation protein ac H9401_4092 ENOG4105C8J )-transporter H9401_4093 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H9401_4095 ENOG41082AN stage II sporulation protein H9401_4096 ENOG4105DZ1 carboxypeptidase H9401_4097 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family H9401_4098 ENOG4105DVE abc transporter atp-binding protein H9401_4105 ENOG4105D7N magnesium and cobalt transport protein CorA H9401_4110 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H9401_4112 ENOG4105I3K Ferric uptake regulator, Fur family H9401_4113 ENOG4105MZ9 stage II sporulation protein m H9401_4118 ENOG4105CPC Aldo Keto reductase H9401_4120 ENOG4105RHY Pfam:UPF0157 H9401_4124 ENOG4107SKW Inherit from COG: Alpha beta hydrolase H9401_4126 ENOG4105ETE Transcriptional regulator (LacI family H9401_4127 ENOG4108YM7 Gcn5-related n-acetyltransferase H9401_4131 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) H9401_4132 ENOG4108R6K riboflavin synthase, subunit alpha H9401_4136 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) H9401_4137 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) H9401_4138 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) H9401_4139 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H9401_4141 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H9401_4144 ENOG4105DFD Na H antiporter H9401_4145 ENOG4105CGH 5'-nucleotidase H9401_4153 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) H9401_4156 ENOG4108IXY short-chain dehydrogenase reductase H9401_4157 ENOG41069FQ Metallo-beta-lactamase superfamily H9401_4159 ENOG4105II7 pyrroline-5-carboxylate reductase H9401_4160 ENOG4105EJQ L-serine dehydratase H9401_4165 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H9401_4166 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) H9401_4167 ENOG4105D9U N-acetyltransferase H9401_4169 ENOG4108VZI ErfK ybiS ycfS ynhG family protein H9401_4170 ENOG4108QEG Membrane H9401_4171 ENOG4105CDA abc transporter atp-binding protein H9401_4172 ENOG4105E5Q amino acid AbC transporter H9401_4173 ENOG4108HW3 (ABC) transporter H9401_4175 ENOG4105G7B Protein of unknown function (DUF2992) H9401_4176 ENOG4105E09 nadh pyrophosphatase H9401_4178 ENOG4105C7S Dehydrogenase H9401_4179 ENOG4105CPP Dehydrogenase, E1 component H9401_4183 ENOG4107RDP Dehydrogenase H9401_4185 ENOG4108JUB Transcriptional regulator H9401_4187 ENOG4108QXE glycerophosphoryl diester phosphodiesterase H9401_4190 ENOG4107QQR Sporulation H9401_4191 ENOG4105S1Z Stage IV sporulation protein B H9401_4192 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) H9401_4194 ENOG4105DX0 Hemolysin A H9401_4196 ENOG4105CTB Polyprenyl synthetase H9401_4201 ENOG4108ZSR alkaline shock protein H9401_4202 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H9401_4206 ENOG410644B Stage III sporulation protein af H9401_4208 ENOG4105KQ4 Stage iii sporulation protein ad H9401_4209 ENOG4108CQH stage III sporulation protein AC H9401_4210 ENOG4105KR5 Stage iii sporulation protein H9401_4211 ENOG4105CD2 stage iii sporulation protein aa H9401_4215 ENOG4105DC7 peptidase M24 H9401_4218 ENOG4105CBJ Metal-dependent enzyme H9401_4220 ENOG4107YBY Hydrolase H9401_4225 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) H9401_4226 ENOG4105WZW rhodanese family H9401_4230 ENOG41080TC multidrug resistance protein H9401_4237 ENOG4105CJ1 ABC, transporter H9401_4238 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family H9401_4244 ENOG4105C0D helicase H9401_4270 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) H9401_4271 ENOG4105C3R Methionine synthase H9401_4273 ENOG4105C28 cystathionine H9401_4274 ENOG4105C28 cystathionine H9401_4278 ENOG4105C5X domain protein H9401_4280 ENOG4105DKQ ROK family H9401_4282 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase H9401_4285 ENOG4108UTW Plays a role in the regulation of phosphate uptake H9401_4286 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) H9401_4287 ENOG4105E2Z phosphate ABC transporter (Permease H9401_4288 ENOG4105C8U phosphate abc transporter H9401_4289 ENOG4105PWN phosphate abc transporter H9401_4290 ENOG4107RF6 penicillin-binding protein H9401_4292 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H9401_4296 ENOG4105N80 Ferric uptake regulator, Fur family H9401_4298 ENOG4105FDK ABC transporter H9401_4299 ENOG4108JYZ YitT family H9401_4300 ENOG41069ZM Protein of unknown function (DUF2624) H9401_4306 ENOG4105EGD dinuclear metal center protein, YbgI family H9401_4309 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H9401_4310 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) H9401_4316 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) H9401_4317 ENOG4105KG3 cytidine deaminase H9401_4318 ENOG4107YR5 Diacylglycerol kinase H9401_4320 ENOG4105CTJ Metal Dependent Phosphohydrolase H9401_4321 ENOG4105C9A Phoh family H9401_4323 ENOG41068P3 sporulation protein YqfC H9401_4324 ENOG4105KTH gatB Yqey H9401_4326 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) H9401_4327 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) H9401_4331 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ H9401_4333 ENOG4105CSA Coproporphyrinogen iii oxidase H9401_4334 ENOG4105KVH Transcriptional regulator H9401_4339 ENOG4105TQK DNA polymerase iii, delta' subunit H9401_4341 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 H9401_4343 ENOG4108UK2 deaminase H9401_4344 ENOG4105KQC Competence protein H9401_4346 ENOG4105DXX methyltransferase H9401_4348 ENOG4108WF2 Metal Dependent Phosphohydrolase H9401_4350 ENOG410812S Rna-binding protein H9401_4352 ENOG4105CQW ribosome biogenesis GTPase YqeH H9401_4353 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase H9401_4356 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H9401_4360 ENOG4108TVJ Nitroreductase H9401_4363 ENOG4105G6Z alkaline phosphatase H9401_4366 ENOG4108MUZ hydrolase H9401_4373 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin H9401_4374 ENOG4105MIR Phenylalanine 4-monooxygenase H9401_4376 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase H9401_4377 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase H9401_4385 ENOG4105S6R Iron-hydroxamate transporter permease subunit H9401_4386 ENOG4108V5C ABC transporter H9401_4388 ENOG4108EKI Dehydrogenase H9401_4389 ENOG4105C28 cystathionine H9401_4395 ENOG4107XRG penicillin-binding protein H9401_4398 ENOG4105CFP Peptidase U32 H9401_4399 ENOG4105XYU peptidase (U32 family) H9401_4400 ENOG4108VQJ O-methyltransferase H9401_4401 ENOG4105HHA aminodeoxychorismate lyase H9401_4405 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H9401_4407 ENOG4105C02 permease H9401_4410 ENOG41060CR H9401_4411 ENOG4105C7H Helicase, RecD TraA family H9401_4413 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) H9401_4414 ENOG4105C3J Cysteine desulfurase H9401_4416 ENOG4105D1H recombination factor protein RarA H9401_4417 ENOG4108VCI transcription factor, rsfa family H9401_4418 ENOG4105CUZ uba thif-type nad fad binding protein H9401_4420 ENOG4105CUT histidyl-tRNA synthetase H9401_4423 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H9401_4425 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) H9401_4426 ENOG41076HS cation diffusion facilitator family transporter H9401_4427 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H9401_4429 ENOG4105CKP Polysaccharide Biosynthesis Protein H9401_4430 ENOG4108QG2 Membrane H9401_4432 ENOG4105VIE preprotein translocase, subunit YajC H9401_4435 ENOG41061AI Protein of unknown function (DUF2905) H9401_4438 ENOG4108HUF Transporter H9401_4440 ENOG4108IPJ Membrane H9401_4441 ENOG4108IPJ Membrane H9401_4442 ENOG41082BM Transcriptional regulator, arsr family H9401_4447 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase H9401_4448 ENOG4108IYU L-aspartate oxidase H9401_4451 ENOG4108RPX mosc domain containing protein H9401_4452 ENOG4105CQC Prephenate dehydratase H9401_4457 ENOG4105EWM Histidine kinase H9401_4460 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control H9401_4463 ENOG4105X36 (ribosomal) protein H9401_4465 ENOG4105C03 ribonuclease H9401_4468 ENOG4107QMS site-determining protein H9401_4471 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) H9401_4472 ENOG4105DFF Rod shape-determining protein mreb H9401_4476 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase H9401_4477 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) H9401_4479 ENOG41068KH stage VI sporulation protein D H9401_4481 ENOG4105D52 delta-aminolevulinic acid dehydratase H9401_4487 ENOG4105K56 Transcriptional regulator H9401_4491 ENOG4108IUQ atp-dependent protease H9401_4496 ENOG4108QCI YvbH-like oligomerisation region H9401_4498 ENOG4105M59 Phosphodiesterase, mj0936 family H9401_4501 ENOG4108XJQ germination protein H9401_4503 ENOG4108PCX Major Facilitator H9401_4506 ENOG4105KBX Transcriptional regulator, TetR family H9401_4509 ENOG4105PFC Transcriptional regulator H9401_4512 ENOG4105DZC cytosine deaminase H9401_4513 ENOG4105DZC cytosine deaminase H9401_4514 ENOG4105DEF Extracellular solute-binding protein, family 5 H9401_4515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H9401_4518 ENOG4108JQ7 (ABC) transporter H9401_4519 ENOG4108HRK Histidine kinase H9401_4520 ENOG4105DY9 regulatoR H9401_4524 ENOG4108JCI Transcriptional regulator H9401_4526 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) H9401_4527 ENOG4108Z40 Transcriptional regulator H9401_4528 ENOG4105RHA ABC transporter, permease H9401_4529 ENOG4108IUX (ABC) transporter H9401_4530 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family H9401_4531 ENOG4105ER2 Ompa motb domain protein H9401_4532 ENOG4105ER2 Ompa motb domain protein H9401_4533 ENOG4105E14 MotA TolQ exbB proton channel H9401_4534 ENOG4108VXD carboxy-peptidase H9401_4536 ENOG4105E33 succinate dehydrogenase H9401_4538 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit H9401_4541 ENOG4105K63 Thioredoxin H9401_4542 ENOG4105C10 Electron transfer flavoprotein H9401_4543 ENOG4105BZJ Electron transfer flavoprotein H9401_4544 ENOG41060WC Enoyl-CoA hydratase H9401_4545 ENOG4107Z3H Transcriptional regulator, TetR family H9401_4546 ENOG4105CEY Amp-dependent synthetase and ligase H9401_4549 ENOG4105J76 Periplasmic binding protein H9401_4550 ENOG4105S6R Iron-hydroxamate transporter permease subunit H9401_4559 ENOG4105DPZ Two component transcriptional regulator (Winged helix family H9401_4562 ENOG4105DR4 Methyltransferase H9401_4565 ENOG4105KFN sortase, SrtB family H9401_4566 ENOG4105E0A ABC, transporter H9401_4569 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) H9401_4571 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) H9401_4573 ENOG4105FE9 pseudouridine synthase H9401_4575 ENOG4105DCG PHP domain protein H9401_4581 ENOG4105C5S asparaginyl-tRNA synthetase H9401_4582 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) H9401_4584 ENOG4108RWN rrna methyltransferase H9401_4591 ENOG4105C0R drug resistance transporter emrb qaca subfamily H9401_4592 ENOG4105CW7 secretion protein, HlyD family H9401_4593 ENOG4108JGH Tetr family transcriptional regulator H9401_4594 ENOG4105CN9 Peptidase m42 family protein H9401_4598 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) H9401_4599 ENOG4105C22 threonyL-tRNA synthetase H9401_4600 ENOG4108TDW sporulation protein YtxC H9401_4604 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) H9401_4606 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H9401_4607 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) H9401_4609 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) H9401_4610 ENOG4105C2M dna polymerase I H9401_4611 ENOG4105BZU Histidine kinase H9401_4612 ENOG4105DPZ Two component transcriptional regulator (Winged helix family H9401_4616 ENOG4108HMX isocitrate dehydrogenase (NADP) H9401_4617 ENOG4105BZN citrate synthase H9401_4619 ENOG4108REF Sporulation integral membrane protein ytvi H9401_4620 ENOG4105FS0 cytoplasmic membrane protein H9401_4625 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family H9401_4626 ENOG4105C6K Malic enzyme H9401_4627 ENOG4105C0B DNA polymerase III (alpha subunit) H9401_4628 ENOG4105VV2 H9401_4630 ENOG4105SFS phosphoesterase RecJ domain protein H9401_4638 ENOG4105DC7 peptidase M24 H9401_4644 ENOG4105Z7P Acetyltransferase (GNAT) family H9401_4645 ENOG41082W1 Cupin 2, conserved barrel domain protein H9401_4647 ENOG4105VZ8 Transcriptional regulator H9401_4651 ENOG4107YZX Universal stress protein H9401_4660 ENOG4108JYZ YitT family H9401_4664 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) H9401_4666 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) H9401_4667 ENOG4105KBJ sporulation protein ytfj H9401_4670 ENOG4105EFZ amidohydrolase H9401_4672 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H9401_4678 ENOG4106KR7 LysR family Transcriptional regulator H9401_4680 ENOG4105U5Y Transcriptional regulator H9401_4681 ENOG4105U5Y Transcriptional regulator H9401_4683 ENOG4105C28 cystathionine H9401_4687 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) H9401_4689 ENOG4105EMN RNA polymerase sigma factor H9401_4692 ENOG4105F1V Acetoin utilization protein H9401_4693 ENOG4105W87 Cbs domain H9401_4694 ENOG4105DGU Histone deacetylase H9401_4696 ENOG4105DPZ Two component transcriptional regulator (Winged helix family H9401_4698 ENOG4107SNB ankyrin repeat protein YahD H9401_4699 ENOG4105EP9 oxidoreductase H9401_4705 ENOG4105ETE Transcriptional regulator (LacI family H9401_4709 ENOG4105C88 aminopeptidase H9401_4717 ENOG4108VDD TRNA binding domain protein H9401_4723 ENOG4105C8F Beta-lactamase domain protein H9401_4726 ENOG4108V15 phosphotransferase enzyme family H9401_4727 ENOG4108IUM Glycogen debranching enzyme H9401_4729 ENOG4107QSE Dipeptidase H9401_4730 ENOG4107QSE Dipeptidase H9401_4731 ENOG4105YW5 deoR family transcriptional regulator H9401_4734 ENOG4105CBX hi0933 family H9401_4742 ENOG4108VJ1 Transcriptional regulator (CarD family H9401_4743 ENOG4107EXU Short-chain dehydrogenase reductase Sdr H9401_4744 ENOG4105CSC Glucose uptake protein H9401_4747 ENOG4108ZAF Molybdopterin H9401_4748 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein H9401_4749 ENOG4105CVM Molybdenum cofactor synthesis domain protein H9401_4751 ENOG4105D06 uba thif-type nad fad binding protein H9401_4752 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H9401_4753 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H9401_4757 ENOG41085GJ domain protein H9401_4759 ENOG4105DWV Homoserine O-trans-acetylase H9401_4763 ENOG4108B31 Spore germination protein H9401_4770 ENOG410605W Major Facilitator H9401_4771 ENOG4107S91 Sodium hydrogen exchanger H9401_4772 ENOG4105NCW Trka-c domain protein H9401_4775 ENOG4105C19 ABC transporter H9401_4779 ENOG4105N5T Radical SAM Protein H9401_4781 ENOG4105DA5 (ABC) transporter H9401_4787 ENOG4105E8V Alpha Beta Hydrolase Fold protein H9401_4788 ENOG4108Z0R Transferase H9401_4789 ENOG4105YVM Phosphoesterase, PA-phosphatase related H9401_4790 ENOG4105BZF Glycosyl transferase (Group 1 H9401_4792 ENOG4108RIR Molybdenum cofactor biosynthesis protein H9401_4801 ENOG4105EGD dinuclear metal center protein, YbgI family H9401_4802 ENOG4105BZU Histidine kinase H9401_4803 ENOG4105BZU Histidine kinase H9401_4804 ENOG4107S9D Alpha beta hydrolase H9401_4805 ENOG4107T7U Sulfatase H9401_4809 ENOG4105D2X ABC transporter substrate-binding protein H9401_4811 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component H9401_4814 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase H9401_4821 ENOG4108V2W Carbonate dehydratase H9401_4822 ENOG4105C4M (Ubiquinol oxidase) subunit I H9401_4823 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H9401_4832 ENOG41087YS Phage shock protein A H9401_4838 ENOG4105BZU Histidine kinase H9401_4839 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H9401_4844 ENOG4108UGV hypoxanthine phosphoribosyltransferase H9401_4845 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) H9401_4852 ENOG4107ZTW SNARE associated Golgi H9401_4855 ENOG4105C19 ABC transporter H9401_4856 ENOG41086D8 Transcriptional regulator H9401_4866 ENOG4105C6Z Gluconate H9401_4867 ENOG4105FDP GntR family transcriptional regulator H9401_4871 ENOG41069H0 dihydroorotase EC 3.5.2.3 H9401_4877 ENOG4105DTQ mandelate racemase muconate lactonizing H9401_4879 ENOG4108IPT Naphthoate synthase H9401_4880 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) H9401_4881 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) H9401_4882 ENOG4105E4F Isochorismate synthase H9401_4883 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase H9401_4885 ENOG4105VEQ Cold shock protein H9401_4889 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) H9401_4891 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) H9401_4893 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) H9401_4894 ENOG4105KT7 mgtC SapB transporter H9401_4895 ENOG4107PBV potassium channel H9401_4897 ENOG4107QYV phosphohexose isomerase H9401_4898 ENOG4105WG9 Conserved Protein H9401_4900 ENOG4105CHM Aminotransferase H9401_4901 ENOG4108ZB6 transcriptional regulator AsnC family H9401_4902 ENOG4105C5I Dehydrogenase H9401_4903 ENOG4108MUZ hydrolase H9401_4905 ENOG4105C87 Aminotransferase class I and II H9401_4908 ENOG4105Y38 Kinase-associated protein B H9401_4910 ENOG4107R3E Citrate transporter H9401_4913 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) H9401_4914 ENOG4105KA0 thioesterase Superfamily protein H9401_4918 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H9401_4922 ENOG41069ER domain protein H9401_4925 ENOG4105CEP NADH dehydrogenase H9401_4931 ENOG4105EWC Purine nucleoside phosphorylase H9401_4935 ENOG4108YX9 iron--sulfur cluster insertion protein erpA H9401_4940 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H9401_4941 ENOG4105C4B ABC transporter, permease H9401_4942 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA H9401_4951 ENOG41083MR nifu domain-containing protein H9401_4954 ENOG4108W5N phosphatidylglycerophosphatase a H9401_4956 ENOG4105DYS nad(p)h dehydrogenase (quinone) H9401_4957 ENOG4105D4U had-superfamily hydrolase, subfamily iia H9401_4960 ENOG4105CBT Fructose-1,6-bisphosphatase H9401_4963 ENOG4105MMD transcriptional regulator H9401_4964 ENOG4107TXC Transcriptional regulator H9401_4965 ENOG41090T1 Membrane H9401_4970 ENOG4105FAA peptidase M23 H9401_4972 ENOG4105KZD Domain of unknown function (DUF1805) H9401_4973 ENOG4107R8B 5'-nucleotidase H9401_4977 ENOG4105DIW FeS assembly protein SUFB H9401_4978 ENOG4108UNV SUF system FeS assembly protein, NifU family H9401_4979 ENOG4105C9B Cysteine desulfurase H9401_4980 ENOG4105JRK feS assembly protein SufD H9401_4981 ENOG4105C3K feS assembly ATPase SufC H9401_4982 ENOG4105D01 (LipO)protein H9401_4983 ENOG4105D01 (LipO)protein H9401_4984 ENOG4108UMI ABC transporter, permease H9401_4991 ENOG41080E8 Transcriptional regulator, Spx MgsR family H9401_4999 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) H9401_5004 ENOG4108W8B Beta-lactamase domain protein H9401_5005 ENOG4105C1G acyl-Coa dehydrogenase H9401_5007 ENOG4105CHU acetyl-coa acetyltransferase H9401_5010 ENOG4105DZ1 carboxypeptidase H9401_5014 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer H9401_5017 ENOG4108SUT Major Facilitator Superfamily H9401_5018 ENOG4107R7I amino acid H9401_5020 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins H9401_5022 ENOG4107AYK membrAne H9401_5029 ENOG4107ZTW SNARE associated Golgi H9401_5031 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein H9401_5032 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H9401_5033 ENOG4105BZU Histidine kinase H9401_5035 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) H9401_5038 ENOG4105VG1 fes assembly suf system protein H9401_5039 ENOG4105D4Y metalloprotease H9401_5043 ENOG4107S91 Sodium hydrogen exchanger H9401_5044 ENOG4105NCW Trka-c domain protein H9401_5046 ENOG4108RMU ferritin dps family protein H9401_5049 ENOG4108URH decarboxylase H9401_5054 ENOG4105D9N nucleoside H9401_5055 ENOG4105D9N nucleoside H9401_5058 ENOG4108RYK Nad-dependent epimerase dehydratase H9401_5063 ENOG4105CV8 reductase H9401_5064 ENOG4105F27 Major Facilitator H9401_5065 ENOG4105KVH Transcriptional regulator H9401_5068 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) H9401_5069 ENOG4105D4A Cell wall formation (By similarity) H9401_5071 ENOG4105C8Q Methyl-accepting chemotaxis H9401_5073 ENOG4105WMR Protein CrcB homolog H9401_5074 ENOG4105WMR Protein CrcB homolog H9401_5077 ENOG4108MK9 spermidine N(1)-acetyltransferase H9401_5078 ENOG4108VY7 phosphate-starvation-inducible protein PsiE H9401_5081 ENOG4108IPW abc transporter atp-binding protein H9401_5082 ENOG4105CM4 permease protein H9401_5088 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) H9401_5090 ENOG4105XZU Preprotein translocase, subunit SecG H9401_5091 ENOG41067MG lrgb family H9401_5108 ENOG4105EFC phage portal protein HK97 family H9401_5114 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H9401_5116 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) H9401_5117 ENOG4105CP7 Triose-phosphate isomerase H9401_5122 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H9401_5125 ENOG41090VF Stage v sporulation protein ac H9401_5126 ENOG4105CZ3 stage V sporulation protein ad H9401_5129 ENOG4105H67 Protein of unknown function (DUF421) H9401_5130 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) H9401_5131 ENOG4105KRI phosphocarrier protein (HPr H9401_5133 ENOG4105CHW UPF0052 protein H9401_5135 ENOG4108Z4K mutator MutT protein H9401_5137 ENOG4105C3M thioredoxin reductase H9401_5139 ENOG4108S4C acetyltransferase H9401_5143 ENOG41086DT Membrane protein of unknown function H9401_5145 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H9401_5146 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) H9401_5147 ENOG4105D7V transposase H9401_5150 ENOG4107TXC Transcriptional regulator H9401_5156 ENOG4105DUM transcriptional regulator, lysR family H9401_5158 ENOG4108WS4 fmn reductase H9401_5161 ENOG4105BZ1 (ABC) transporter H9401_5163 ENOG4105CN1 protease H9401_5164 ENOG4105CRP Part of the ABC transporter FtsEX involved in H9401_5165 ENOG4105CAK Cell division ATP-binding protein ftsE H9401_5170 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving H9401_5171 ENOG4105MS2 ribosomal subunit Interface protein H9401_5173 ENOG4105VEQ Cold shock protein H9401_5174 ENOG41081UC Inherit from COG: Competence protein H9401_5177 ENOG4105KVH Transcriptional regulator H9401_5179 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein H9401_5180 ENOG4108KGH TRANSCRIPTIONal H9401_5181 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase H9401_5182 ENOG4105C6Y Udp-glucose 6-dehydrogenase H9401_5183 ENOG4105ESV Glycosyl transferase, family 4 H9401_5185 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H9401_5188 ENOG410901P UPF0249 protein H9401_5189 ENOG4105F8D glycoside hydrolase family 4 H9401_5190 ENOG4105VCP PTS System H9401_5191 ENOG4105CK1 PTS System H9401_5193 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) H9401_5194 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) H9401_5195 ENOG4105VCP PTS System H9401_5197 ENOG4105VZJ PTS System H9401_5200 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase H9401_5201 ENOG4105ECB domain protein H9401_5202 ENOG4107RSM transcriptional regulator H9401_5210 ENOG4105DAA L-lactate H9401_5212 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) H9401_5214 ENOG4105E0M Sulfatase H9401_5221 ENOG4107R8N Glycosyl transferase, family 2 H9401_5223 ENOG4105C94 Transporter H9401_5224 ENOG41069ER domain protein H9401_5229 ENOG4105KBK Zinc finger, swim domain protein H9401_5230 ENOG4105C0D helicase H9401_5236 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H9401_5238 ENOG4107RBB ABC transporter, permease H9401_5239 ENOG4105C19 ABC transporter H9401_5242 ENOG4105CXY transporter H9401_5245 ENOG4105BZU Histidine kinase H9401_5246 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H9401_5247 ENOG4105CMR udp-glucose 4-epimerase H9401_5251 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase H9401_5252 ENOG4105EY8 ABC transporter H9401_5264 ENOG4105MT0 Sporulation transcriptional regulator spoiiid H9401_5267 ENOG4105FRN stage II sporulation protein H9401_5270 ENOG4105DY9 regulatoR H9401_5271 ENOG4108IUW ABC transporter H9401_5275 ENOG4106778 Protein of unknown function (DUF1146) H9401_5276 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H9401_5277 ENOG4105C8S subunit m H9401_5278 ENOG4105D65 subunit l H9401_5283 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H9401_5284 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain H9401_5286 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain H9401_5287 ENOG4105BZU Histidine kinase H9401_5297 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) H9401_5298 ENOG41062M3 atp synthase H9401_5304 ENOG4108YZG isomerase H9401_5305 ENOG4107WAU Protein tyrosine phosphatase H9401_5307 ENOG4108VGI doxx family H9401_5308 ENOG4107XC4 flavin reductase domain protein, FMN-binding H9401_5311 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H9401_5313 ENOG4108ZXQ stage ii sporulation protein r H9401_5314 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H9401_5315 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) H9401_5318 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) H9401_5319 ENOG4105CBT Fructose-1,6-bisphosphatase H9401_5320 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) H9401_5327 ENOG4105C1G acyl-Coa dehydrogenase H9401_5328 ENOG4105C1G acyl-Coa dehydrogenase H9401_5329 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H9401_5331 ENOG4105DF6 Fe-S oxidoreductase H9401_5334 ENOG4105BZU Histidine kinase H9401_5339 ENOG4105BZU Histidine kinase H9401_5340 ENOG4105KCT ABC transporter H9401_5341 ENOG4108M15 ABC transporter H9401_5342 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) H9401_5347 ENOG4105IIU Aminopeptidase H9401_5351 ENOG4105EMN RNA polymerase sigma factor H9401_5353 ENOG410684U Domain of unknown function (DUF1934) H9401_5358 ENOG4105CYW agmatinase H9401_5360 ENOG4105DXB Major Facilitator superfamily H9401_5361 ENOG4107SWG transcriptional regulator MERR family H9401_5363 ENOG4108QXE glycerophosphoryl diester phosphodiesterase H9401_5364 ENOG4105BZ4 penicillin-binding protein H9401_5365 ENOG4108XFG YwhD family H9401_5366 ENOG4108Z4T Peptidase M50 H9401_5367 ENOG41069HH 4-oxalocrotonate tautomerase H9401_5368 ENOG4105DCI Phosphohydrolase H9401_5369 ENOG4108MES Periplasmic binding protein H9401_5370 ENOG4105E0A ABC, transporter H9401_5371 ENOG4105EHG Permease protein H9401_5372 ENOG4105DQ5 transport system permease protein H9401_5373 ENOG4105DQ5 transport system permease protein H9401_5375 ENOG4108VCI transcription factor, rsfa family H9401_5378 ENOG4108IJ2 phosphate acetyltransferase H9401_5381 ENOG4108VKI Cell wall hydrolase H9401_5385 ENOG4107SVH Potassium channel protein H9401_5387 ENOG410667J hydrolase H9401_5388 ENOG4105VCH membrane H9401_5390 ENOG4108TU7 Inherit from COG: (ABC) transporter H9401_5391 ENOG4105CJ1 ABC, transporter H9401_5392 ENOG41090WU lipolytic protein G-D-S-L family H9401_5395 ENOG4105D6E homoserine dehydrogenase H9401_5396 ENOG4105D6E homoserine dehydrogenase H9401_5401 ENOG4108Y4K DNA-binding transcriptional activator H9401_5403 ENOG4105WH1 Two component transcriptional regulator luxr family H9401_5404 ENOG4105BZU Histidine kinase H9401_5405 ENOG4105BZU Histidine kinase H9401_5406 ENOG4105DWF phosphomethylpyrimidine kinase H9401_5407 ENOG4105BZU Histidine kinase H9401_5408 ENOG4105VCD cytoplasmic protein H9401_5409 ENOG4105D22 carbon starvation protein H9401_5410 ENOG4105DY9 regulatoR H9401_5411 ENOG41079KZ Major Facilitator Superfamily H9401_5416 ENOG4105EN6 Membrane H9401_5417 ENOG4106YBV Methyl-accepting chemotaxis H9401_5419 ENOG4108S4H thioesterase Superfamily protein H9401_5421 ENOG4105JEU Glycosyl transferase, family 2 H9401_5422 ENOG4105C5H ABC transporter H9401_5427 ENOG4105CKK Glycosyl transferase, family 2 H9401_5428 ENOG41067SE Tetr family transcriptional regulator H9401_5430 ENOG4105E0X reductase H9401_5431 ENOG4106F5Q Membrane H9401_5434 ENOG4105DY9 regulatoR H9401_5435 ENOG4108HRK Histidine kinase H9401_5436 ENOG4107RGD Major Facilitator superfamily H9401_5439 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H9401_5441 ENOG4105IW1 AmiS UreI transporter H9401_5443 ENOG4105CMR udp-glucose 4-epimerase H9401_5444 ENOG4108UT2 hemolysin iii H9401_5446 ENOG4105C1J atp-dependent rna helicase H9401_5449 ENOG4105DPN Oligoendopeptidase f H9401_5453 ENOG4105C0H protease H9401_5454 ENOG4105Q2H domain protein H9401_5457 ENOG4105BZU Histidine kinase H9401_5458 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H9401_5460 ENOG4105CDU Replicative dna helicase H9401_5462 ENOG4105BZR domain protein H9401_5463 ENOG4108XMW Membrane H9401_5465 ENOG4108UUM single-stranded DNA-binding protein H9401_5467 ENOG4105C3G gtp-binding protein H9401_5468 ENOG4105VDK protein, conserved in bacteria H9401_5469 ENOG4105D8X mechanosensitive ion channel H9401_5470 ENOG4108ZDA Sporulation protein YyaC H9401_5471 ENOG4105FA0 parb-like partition protein H9401_5472 ENOG4107QJE Chromosome Partitioning Protein H9401_5476 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) H9401_5478 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins H9401_5492 ENOG4105EKQ RNA-directed DNA polymerase H9401_5514 ENOG4105EKQ RNA-directed DNA polymerase H9401_5525 ENOG4106JUT Streptomycin 3''-adenylyltransferase H9401_5539 ENOG4105CNU cell division protein FtsK H9401_5588 ENOG4105DHF Membrane H9401_5594 ENOG4106AKK s-layer domain-containing protein H9401_5595 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H9401_5600 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H9401_5601 ENOG4105C6Y Udp-glucose 6-dehydrogenase H9401_5604 ENOG4105DQ6 Transposase H9401_5605 ENOG4105DQ6 Transposase H9401_5615 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) H9401_5646 ENOG4105KRN Transcriptional regulator, abrb family H9401_5648 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H9401_5655 ENOG4108IBT Inherit from COG: transposase H9401_5657 ENOG4105DQ6 Transposase H9401_5658 ENOG4105DQ6 Transposase H9401_5661 ENOG4105DQ6 Transposase H9401_5662 ENOG4105DQ6 Transposase H9401_5664 ENOG4108MEK Metal-binding protein YodA H9401_5666 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) H9401_5673 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) H9401_5688 ENOG4105K4H Nlp p60 protein H9401_5724 ENOG4107QJE Chromosome Partitioning Protein H9401_5731 ENOG4105DQ6 Transposase H9401_5737 ENOG4105EWC Purine nucleoside phosphorylase H9401_5756 ENOG4105C3F Signal peptidase i H9401_5762 ENOG4105N14 lysine exporter protein LysE YggA H9401_5770 ENOG4108J59 Extracellular solute-binding protein, family 5 H9401_5774 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H9401_5784 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H9401_5785 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H9401_trnaLeu6 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation