locus-tag class description AW20_1 ENOG4105BZG amino acid carrier protein AW20_1002 ENOG4105CJ1 ABC, transporter AW20_1009 ENOG4106BRA Membrane AW20_1016 ENOG4107QIV Cytochrome c biogenesis protein AW20_102 ENOG4105DY8 decarboxylase AW20_1020 ENOG4105EC3 peptidase S51, dipeptidase E AW20_1021 ENOG4107QJQ Mate efflux family protein AW20_1022 ENOG4107QJQ Mate efflux family protein AW20_1026 ENOG4105C9Q fumarate hydratase class II AW20_1027 ENOG4105DFD Na H antiporter AW20_1030 ENOG4108PJD permease AW20_1031 ENOG4105CKI cobalamin synthesis protein AW20_1032 ENOG4108UZ3 Transporter AW20_1033 ENOG4105DRR Transcriptional regulator, GntR family AW20_1035 ENOG4105PGM cation diffusion facilitator family transporter AW20_1039 ENOG4105CAQ asparagine synthetase AW20_1046 ENOG4105CVJ phosphoglycerate mutase AW20_1053 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AW20_1054 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AW20_1055 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AW20_1056 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW20_1062 ENOG4105KAC Antibiotic biosynthesis monooxygenase AW20_1066 ENOG4108RZE Tetr family transcriptional regulator AW20_107 ENOG4105PAD Hydrolase AW20_1071 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AW20_1072 ENOG4105KTQ flagellar basal-body rod protein AW20_1075 ENOG4105D7B Flagellar biosynthesis protein flha AW20_1076 ENOG4105D00 flagellar biosynthetic protein flhB AW20_1078 ENOG4105VS8 Flagellar biosynthetic protein fliq AW20_1079 ENOG4105CN7 Flagellar biosynthetic protein FliP AW20_1081 ENOG4105DD5 Flagellar motor switch protein AW20_1083 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AW20_1084 ENOG4105E4C Lytic transglycosylase catalytic AW20_1085 ENOG4105I03 Flagellin AW20_1090 ENOG4107TVC Glycosyl transferase, family 2 AW20_1096 ENOG4105K64 Glycosyl transferase, family 2 AW20_1098 ENOG4107R88 Chemotaxis protein (CheV) AW20_1099 ENOG4107R88 Chemotaxis protein (CheV) AW20_1103 ENOG4105BZE flagellar hook protein, FlgE AW20_1110 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AW20_1112 ENOG4107U2N Flagellar M-ring protein AW20_1114 ENOG4108ZC9 flagellar basal-body rod protein flgc AW20_1115 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AW20_112 ENOG4107VFR oxidoreductase AW20_1120 ENOG4105DTJ flagellar hook-associated protein AW20_1121 ENOG4105E1Q flagellar hook-associated protein AW20_1125 ENOG4105BZU Histidine kinase AW20_1128 ENOG4105DD5 Flagellar motor switch protein AW20_1129 ENOG4105CBS Chea signal transduction histidine kinase AW20_1130 ENOG4105CBS Chea signal transduction histidine kinase AW20_1131 ENOG4107YTP response regulator receiver protein AW20_1132 ENOG4105ER2 Ompa motb domain protein AW20_1133 ENOG4107R0U MotA TolQ exbB proton channel AW20_1135 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AW20_1146 ENOG41080C8 DUF218 domain AW20_1147 ENOG4105H67 Protein of unknown function (DUF421) AW20_1149 ENOG4108Z5V transcriptional regulator, merr family AW20_1150 ENOG4105CN5 Metallo-Beta-Lactamase AW20_1151 ENOG4107RWR Sodium hydrogen exchanger AW20_1153 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW20_1166 ENOG41081VK Ribonuclease AW20_1170 ENOG4108SZE gCN5-related N-acetyltransferase AW20_1173 ENOG4105CPK Glycosyl transferase (Group 1 AW20_1186 ENOG4106032 Glutathionylspermidine synthase AW20_1189 ENOG4105KHC sulfurtransferase AW20_1191 ENOG4108W0I acetyltransferase AW20_1193 ENOG410890F Dynamin family AW20_1195 ENOG4105DHF Membrane AW20_1196 ENOG4105C2W permease AW20_1198 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AW20_12 ENOG4105C9U ATP-dependent DNA helicase RecQ AW20_120 ENOG4105PKS Excinuclease abc c subunit domain protein AW20_1201 ENOG4105CTD carboxy-peptidase AW20_1202 ENOG4105DVT helicase AW20_1204 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AW20_1215 ENOG4105BZ4 penicillin-binding protein AW20_1217 ENOG4105CSM endonuclease III AW20_1221 ENOG4105YAC AW20_1222 ENOG4105DVT helicase AW20_1229 ENOG4105CPK Glycosyl transferase (Group 1 AW20_1230 ENOG4105FJR Lmbe family AW20_1233 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AW20_1234 ENOG4108JYZ YitT family AW20_1240 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AW20_1241 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AW20_1242 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AW20_1245 ENOG41068YB TPR repeat-containing protein AW20_1246 ENOG4105CIH Imidazole acetol-phosphate transaminase AW20_1250 ENOG4105EAH synthase AW20_1252 ENOG4105XXQ heptaprenyl diphosphate synthase component I AW20_1255 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AW20_1261 ENOG41065D1 AW20_1262 ENOG4105S2F AW20_1269 ENOG4107RB3 L-asparaginase AW20_1270 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AW20_1275 ENOG4108S6Z Negative regulator of genetic competence AW20_1276 ENOG4107X2D transcriptional regulator, merr family AW20_1277 ENOG4107RGJ metallophosphoesterase AW20_1279 ENOG4105I7S Abortive infection protein AW20_128 ENOG4105KWG Pfam:DUF1696 AW20_1280 ENOG4105C9U ATP-dependent DNA helicase RecQ AW20_1281 ENOG4105T7X AW20_1283 ENOG4108SAX Membrane AW20_1286 ENOG4108WBT adenosyltransferase AW20_1287 ENOG4105BZU Histidine kinase AW20_1288 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_1289 ENOG4105CRE cytochrome C AW20_129 ENOG4108NRW Phospholipase, patatin family AW20_1290 ENOG4107TWT Cytochrome c biogenesis protein AW20_1292 ENOG4105FE9 pseudouridine synthase AW20_1294 ENOG4108JIC nucleoside recognition domain protein AW20_1295 ENOG4105DZ1 carboxypeptidase AW20_1296 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW20_1303 ENOG4105BZU Histidine kinase AW20_1306 ENOG4105I3N Conserved Protein AW20_1307 ENOG4105BZU Histidine kinase AW20_1310 ENOG4105BZ4 penicillin-binding protein AW20_1311 ENOG4107GRR phosphate transport regulator AW20_1312 ENOG4105CJ3 phosphate transporter AW20_1316 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AW20_1321 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AW20_1325 ENOG4105WH1 Two component transcriptional regulator luxr family AW20_1326 ENOG4105ENE Histidine kinase AW20_1330 ENOG4105DFD Na H antiporter AW20_1334 ENOG4105C8J )-transporter AW20_1335 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AW20_1336 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AW20_1337 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AW20_1339 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AW20_1340 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AW20_1344 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AW20_1346 ENOG4105E0M Sulfatase AW20_1347 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AW20_135 ENOG4108XI2 Domain of unknown function (DUF1963) AW20_1350 ENOG4107RVV histidinol phosphate phosphatase, hisj family AW20_1357 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AW20_1362 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AW20_1364 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AW20_1365 ENOG4108ZP8 Acetolactate synthase small subunit AW20_1366 ENOG4105C7K acetolactate synthase AW20_1367 ENOG4105CM2 brancheD-chain amino acid aminotransferase AW20_1372 ENOG4105KBJ sporulation protein ytfj AW20_1373 ENOG41063Y9 AW20_1374 ENOG4105CZN Potassium uptake protein AW20_1380 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AW20_1381 ENOG4107QMU Mate efflux family protein AW20_1388 ENOG4105NQC Flavodoxin AW20_1393 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AW20_1395 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AW20_1396 ENOG4105EA8 2-Nitropropane dioxygenase AW20_1397 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AW20_1405 ENOG4105CJ1 ABC, transporter AW20_1407 ENOG4105CZV ABC transporter AW20_1408 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AW20_1409 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AW20_1410 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AW20_1412 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AW20_1413 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AW20_142 ENOG4108Z4K mutator MutT protein AW20_1421 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AW20_1422 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AW20_1424 ENOG4105BZU Histidine kinase AW20_1426 ENOG4106DF1 AW20_1428 ENOG41090MY MarR family Transcriptional regulator AW20_1429 ENOG4105BZU Histidine kinase AW20_143 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AW20_1431 ENOG4105PXI polysaccharide deacetylase AW20_1433 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AW20_1434 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AW20_1439 ENOG4105E98 transcriptional regulator DeoR family AW20_144 ENOG4105E09 nadh pyrophosphatase AW20_1443 ENOG4107RCV ABC transporter, permease AW20_1446 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW20_1448 ENOG4105C4Y ABC transporter AW20_1452 ENOG4105MWK D-amino acid dehydrogenase, small subunit AW20_1454 ENOG4105CHR reductase AW20_1458 ENOG4108Z7G MaoC domain protein dehydratase AW20_1459 ENOG410681C small acid-soluble spore protein AW20_146 ENOG4105FCD Major Facilitator AW20_1460 ENOG4105CZN Potassium uptake protein AW20_1461 ENOG4107TS3 membrane protein, TerC AW20_1462 ENOG4108QTI )-transporter AW20_1464 ENOG4106A3R peptidase AW20_1468 ENOG4105JXH GntR family transcriptional regulator AW20_1469 ENOG4105BZU Histidine kinase AW20_1470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_1473 ENOG4105CQB FAD linked oxidase domain protein AW20_1474 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AW20_1475 ENOG4105K4I Scp-like extracellular AW20_1477 ENOG4108YBP pseudouridine synthase AW20_1479 ENOG4105EYF MMPL domain protein AW20_1481 ENOG4107RUE extracellular solute-binding protein family 1 AW20_1482 ENOG4105D38 putrescine abc transporter AW20_1483 ENOG4105F38 ABC transporter, permease AW20_1484 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW20_1485 ENOG4105C26 Dehydrogenase AW20_1491 ENOG4105VFR signal peptidase AW20_1492 ENOG4105DZ1 carboxypeptidase AW20_1494 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AW20_1505 ENOG4105VZ8 Transcriptional regulator AW20_1507 ENOG4105C7S Dehydrogenase AW20_1525 ENOG4105DDQ anthranilate synthase AW20_1527 ENOG4105CK7 Sodium proline symporter AW20_153 ENOG4107Y9U Membrane AW20_1541 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AW20_1543 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AW20_1544 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AW20_1548 ENOG4107TVC Glycosyl transferase, family 2 AW20_1553 ENOG4105K64 Glycosyl transferase, family 2 AW20_1555 ENOG4105CNI cell division protein FtsW AW20_1559 ENOG4105EMS pseudouridine synthase AW20_1563 ENOG4105MIX Adenylate cyclase AW20_1564 ENOG4108Z18 K06886 hemoglobin AW20_1567 ENOG4105DPN Oligoendopeptidase f AW20_1569 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW20_1571 ENOG4108ZCF integral membrane protein AW20_1575 ENOG4105UQX Mate efflux family protein AW20_1576 ENOG4108JQ7 (ABC) transporter AW20_1578 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW20_1579 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW20_158 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AW20_1582 ENOG4105C31 Tryptophanyl-tRNA synthetase AW20_1585 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AW20_1586 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AW20_1591 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AW20_1593 ENOG4108KP7 hydrolase AW20_1595 ENOG41073B9 AW20_1596 ENOG4107AYK membrAne AW20_1598 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AW20_16 ENOG4105EEM helicase AW20_1600 ENOG4105QNR S1 RNA binding domain protein AW20_1604 ENOG4105BZU Histidine kinase AW20_1605 ENOG4105CH6 catalase AW20_1606 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AW20_1607 ENOG4105CAQ asparagine synthetase AW20_1612 ENOG4105ERH Fumarylacetoacetate hydrolase AW20_162 ENOG4107Y80 Major Facilitator superfamily AW20_1620 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AW20_1621 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AW20_1624 ENOG4105XVF Competence transcription factor AW20_1631 ENOG4107QP3 malate synthase g AW20_1636 ENOG4105C8Q Methyl-accepting chemotaxis AW20_1637 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AW20_1642 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW20_1646 ENOG41086D8 Transcriptional regulator AW20_1647 ENOG4108AEY RNA polymerase sigma factor AW20_1649 ENOG4107TVP HD domain protein AW20_1650 ENOG4107RN3 metallophosphoesterase AW20_1652 ENOG4105ENX hydrolase AW20_1657 ENOG4105CNA YD repeat protein AW20_1663 ENOG4105CEY Amp-dependent synthetase and ligase AW20_1665 ENOG4105DF9 Lipoate-protein, ligase AW20_1666 ENOG4108RQ5 Beta-lactamase domain-containing protein AW20_1667 ENOG4106AXD AW20_167 ENOG4108V4B ThiJ pfpI AW20_1674 ENOG4105ECB domain protein AW20_1677 ENOG4105NA0 Transcriptional regulator AW20_1682 ENOG4105C1Q protoporphyrinogen oxidase AW20_1684 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AW20_1685 ENOG4105BZ4 penicillin-binding protein AW20_1686 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AW20_1687 ENOG4105CKV Membrane AW20_1688 ENOG410905X membrane-flanked domain protein AW20_1697 ENOG4105CKV Membrane AW20_1699 ENOG410905X membrane-flanked domain protein AW20_1706 ENOG4105K59 histidine triad (HIT) protein AW20_1711 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AW20_1712 ENOG4105EEM helicase AW20_1714 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW20_1715 ENOG4105C57 major facilitator superfamily AW20_1720 ENOG4105EMN RNA polymerase sigma factor AW20_1723 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AW20_1726 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AW20_173 ENOG4105FQP Beta-lactamase AW20_1731 ENOG4108MUZ hydrolase AW20_1736 ENOG4105EQ0 Major Facilitator superfamily AW20_1737 ENOG4108IND Tetr family transcriptional regulator AW20_1740 ENOG4105D7V transposase AW20_1741 ENOG4106D4I domain protein AW20_1742 ENOG4107VRP DNA repair exonuclease AW20_175 ENOG4105CJN penicillin-binding protein AW20_1753 ENOG4105BZU Histidine kinase AW20_1754 ENOG4105BZU Histidine kinase AW20_1755 ENOG4108MJI response regulator AW20_1757 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_1759 ENOG4105WN5 stage II sporulation protein AW20_176 ENOG4105CB2 alcohol dehydrogenase AW20_1772 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AW20_1777 ENOG410847I Transcriptional regulator, BadM Rrf2 family AW20_1778 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AW20_1779 ENOG4105CMT Dihydroxyacetone kinase AW20_1781 ENOG4105CMT Dihydroxyacetone kinase AW20_1785 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AW20_1789 ENOG4108IG5 Transcriptional regulator AW20_179 ENOG4108HGU Histidine kinase AW20_1790 ENOG4107P5I polyketide synthase AW20_1800 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW20_1808 ENOG4105CDU Replicative dna helicase AW20_1817 ENOG4108MRH transcriptional regulatory protein AW20_1819 ENOG4105CSH Transporter AW20_182 ENOG4108JJB ABC transporter AW20_1825 ENOG4108JQ7 (ABC) transporter AW20_1828 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW20_1836 ENOG4105CTU Proline racemase AW20_1840 ENOG4105DER m42 family AW20_1843 ENOG4105CGU Enoyl-CoA hydratase AW20_1846 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AW20_1847 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AW20_1849 ENOG4106AKK s-layer domain-containing protein AW20_1857 ENOG4105CHH sulfate transporter AW20_186 ENOG4107RF6 penicillin-binding protein AW20_1860 ENOG4105D4P Coproporphyrinogen iii oxidase AW20_1862 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW20_1867 ENOG4107FQX Alpha-acetolactate decarboxylase AW20_187 ENOG4105BZU Histidine kinase AW20_1874 ENOG410839P AW20_1877 ENOG4105CDA abc transporter atp-binding protein AW20_1878 ENOG4105DRP amino acid AbC transporter AW20_1880 ENOG4105BZ1 (ABC) transporter AW20_1881 ENOG4105BZ1 (ABC) transporter AW20_1882 ENOG4105BZ1 (ABC) transporter AW20_1883 ENOG4105C26 Dehydrogenase AW20_1885 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AW20_1886 ENOG4105D5Q Arginine ornithine antiporter AW20_1888 ENOG4105CH6 catalase AW20_1889 ENOG4107RKG DJ-1/PfpI family AW20_189 ENOG410667J hydrolase AW20_1891 ENOG4105E5W Transporter AW20_1892 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AW20_1893 ENOG4105NF4 modulator of drug activity AW20_1898 ENOG4105KPY Small multidrug resistance protein AW20_1901 ENOG4108YXU transcriptional regulator AsnC family AW20_1902 ENOG4108PCN EamA-like transporter family AW20_1909 ENOG4106KNT transcriptional regulator AW20_1911 ENOG4107RWR Sodium hydrogen exchanger AW20_1912 ENOG4105CUB amino acid AW20_1918 ENOG4107T5V SNARE associated Golgi AW20_1925 ENOG4105WEF catalase AW20_1931 ENOG4105C19 ABC transporter AW20_1932 ENOG4107RBB ABC transporter, permease AW20_1933 ENOG41069ER domain protein AW20_1937 ENOG4105VZJ PTS System AW20_1938 ENOG4105VCP PTS System AW20_1939 ENOG4105EMD TRANSCRIPTIONal AW20_1944 ENOG4108KGH TRANSCRIPTIONal AW20_1946 ENOG41087NI Sulfite exporter TauE/SafE AW20_1947 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AW20_1949 ENOG41085GJ domain protein AW20_1951 ENOG4105VFE sira family AW20_1952 ENOG4107TPS domain protein AW20_1953 ENOG4105VFE sira family AW20_1954 ENOG4105XTG Pfam:DUF156 AW20_1955 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AW20_1960 ENOG4105ED1 spovr family AW20_1961 ENOG4107Y03 Nitroreductase AW20_1966 ENOG4108B31 Spore germination protein AW20_1973 ENOG4105C5Y PTS System AW20_1980 ENOG4105C7N Xanthine uracil vitamin C permease AW20_1983 ENOG4108INS Transcriptional regulator AW20_1992 ENOG4105DWF phosphomethylpyrimidine kinase AW20_1993 ENOG4105D06 uba thif-type nad fad binding protein AW20_1996 ENOG41080HI glycine oxidase AW20_1997 ENOG4108VEU Thiamine monophosphate synthase AW20_1999 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AW20_2001 ENOG4105ETU transcriptional activator (TenA AW20_2005 ENOG41080XQ Signal transduction protein with cbs domains AW20_2030 ENOG4105E2Z phosphate ABC transporter (Permease AW20_2031 ENOG4105C8U phosphate abc transporter AW20_2032 ENOG4105CVA phosphate AW20_2033 ENOG4105CE1 Ferrous iron transport protein b AW20_2034 ENOG4105CE1 Ferrous iron transport protein b AW20_2035 ENOG4105CE1 Ferrous iron transport protein b AW20_2036 ENOG4108NHD germination protein AW20_2039 ENOG4105E1V na solute symporter AW20_2040 ENOG4106CAD Protein of unknown function (DUF3311) AW20_2043 ENOG4105E2S oxidase) subunit II AW20_2044 ENOG4105BZ9 Cytochrome C oxidase, subunit I AW20_2052 ENOG4105C7N Xanthine uracil vitamin C permease AW20_2053 ENOG4105C85 amino acid AW20_2057 ENOG4105DUX Transporter AW20_2059 ENOG4107D63 AW20_2060 ENOG4105VZ8 Transcriptional regulator AW20_2061 ENOG41069ER domain protein AW20_2062 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AW20_2063 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AW20_2076 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AW20_2077 ENOG4105CNN ABC, transporter AW20_2080 ENOG4108RVA ribokinase AW20_2081 ENOG4105ETE Transcriptional regulator (LacI family AW20_2082 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW20_2083 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW20_2084 ENOG41067TZ transcriptional regulator, MarR family AW20_2085 ENOG4105CXY transporter AW20_2087 ENOG4108JQ7 (ABC) transporter AW20_2088 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW20_2090 ENOG4105DEF Extracellular solute-binding protein, family 5 AW20_2092 ENOG41068KF Universal stress protein AW20_2093 ENOG4105CHH sulfate transporter AW20_2096 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_2097 ENOG4105BZU Histidine kinase AW20_2098 ENOG4105NAE bifunctional deaminase-reductase domain protein AW20_2099 ENOG4105D29 Helix-turn-helix type 11 domain protein AW20_2104 ENOG4108IQI permease AW20_2105 ENOG4105DRP amino acid AbC transporter AW20_2106 ENOG4105EAD ABC transporter AW20_2107 ENOG4105CT1 (ABC) transporter AW20_2108 ENOG4105CDA abc transporter atp-binding protein AW20_2109 ENOG4105BZG amino acid carrier protein AW20_2110 ENOG4105CRN Aminoglycoside phosphotransferase AW20_2112 ENOG4105E1K spore germination protein AW20_2115 ENOG4105CG3 alpha amylase, catalytic region AW20_2116 ENOG4105C5Y PTS System AW20_2117 ENOG4107414 GntR family transcriptional regulator AW20_2118 ENOG4105D5Q Arginine ornithine antiporter AW20_2119 ENOG4105BZU Histidine kinase AW20_212 ENOG4105ETU transcriptional activator (TenA AW20_2122 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW20_2123 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AW20_2124 ENOG4107T89 von Willebrand factor, type A AW20_2126 ENOG4105EXW epimerase dehydratase AW20_2129 ENOG4105DMQ Methyltransferase AW20_2130 ENOG4105E0A ABC, transporter AW20_2131 ENOG4108IHU transport system permease protein AW20_2132 ENOG4105DQ5 transport system permease protein AW20_2133 ENOG4108MES Periplasmic binding protein AW20_2134 ENOG4105DUX Transporter AW20_2137 ENOG4105DAA L-lactate AW20_2138 ENOG4108IJ0 Aspartate ammonia-lyase AW20_2139 ENOG4105C37 (CBS) domain AW20_2140 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AW20_2141 ENOG4105D9N nucleoside AW20_2142 ENOG4108KGH TRANSCRIPTIONal AW20_2143 ENOG41073R8 VanW family AW20_2150 ENOG4105DAP Nicotinate phosphoribosyltransferase AW20_2151 ENOG4105C59 p-type ATPase AW20_2153 ENOG4105CUB amino acid AW20_2158 ENOG4108JB9 formate dehydrogenase AW20_2159 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AW20_2160 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AW20_2162 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_2163 ENOG4105BZU Histidine kinase AW20_2165 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW20_2166 ENOG4108UZ3 Transporter AW20_2168 ENOG4105C6K Malic enzyme AW20_2170 ENOG4108MRH transcriptional regulatory protein AW20_2175 ENOG4105US7 Histidine kinase AW20_2176 ENOG4108STX response regulator AW20_2177 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AW20_2178 ENOG4105BZ7 extracellular solute-binding protein family 1 AW20_2179 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AW20_2180 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AW20_2181 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW20_2182 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AW20_2186 ENOG4105D4T Citrate transporter AW20_2189 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AW20_2191 ENOG4105DZ6 Band 7 protein AW20_2194 ENOG4105C94 Transporter AW20_2198 ENOG4105CYN Serine protein kinase AW20_2200 ENOG4105BZU Histidine kinase AW20_2201 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AW20_2203 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AW20_2205 ENOG4107ZQN disulfide bond AW20_2206 ENOG4108JQC penicillin-binding protein 1A AW20_2231 ENOG4105G5W regulator Fur family AW20_2232 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AW20_2236 ENOG4108IUW ABC transporter AW20_2238 ENOG4105CBC glutamate synthase AW20_2239 ENOG4107NBY Membrane AW20_2240 ENOG4105BZ1 (ABC) transporter AW20_2244 ENOG4106BXE AW20_2245 ENOG4105CEN a g-specific adenine glycosylase AW20_2246 ENOG41067AE Membrane-bound metal-dependent hydrolase AW20_2252 ENOG4105ECP epimerase AW20_2253 ENOG4105CI2 imidazolone-5-propionate hydrolase AW20_2257 ENOG4105F1A Pyruvate formate-lyase AW20_2260 ENOG4105C3I Nad-dependent epimerase dehydratase AW20_2261 ENOG4107QQG Dehydrogenase AW20_2263 ENOG4105CKK Glycosyl transferase, family 2 AW20_2266 ENOG4108A04 Beta-lactamase AW20_2274 ENOG4108IQI permease AW20_2276 ENOG4108JUB Transcriptional regulator AW20_2278 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AW20_2336 ENOG4105VTR Integrase AW20_2337 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AW20_234 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AW20_2345 ENOG4105UPD Calcium Proton AW20_2346 ENOG410606W general stress protein AW20_2349 ENOG4107ZTW SNARE associated Golgi AW20_235 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AW20_2352 ENOG4105C3F Signal peptidase i AW20_2354 ENOG4108IPJ Membrane AW20_2355 ENOG4105C59 p-type ATPase AW20_2356 ENOG4107U9T Pfam:Ribonuclease_BN AW20_2358 ENOG4105KJF protein tyrosine phosphatase AW20_2362 ENOG4108TTB tellurium resistance protein AW20_2363 ENOG4107TS3 membrane protein, TerC AW20_2364 ENOG4106FN3 tellurium resistance protein AW20_2365 ENOG4106FN3 tellurium resistance protein AW20_2366 ENOG4108N0M stress protein AW20_2369 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) AW20_2372 ENOG4105DEU major facilitator superfamily AW20_2376 ENOG41062JF Transcriptional regulator AW20_238 ENOG4105CPQ Dehydrogenase AW20_2381 ENOG4105C5H ABC transporter AW20_2384 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AW20_2387 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AW20_2393 ENOG4105CI1 PTS System AW20_2395 ENOG4105C8Q Methyl-accepting chemotaxis AW20_2396 ENOG4105C8Q Methyl-accepting chemotaxis AW20_2398 ENOG4105EAB amino acid AbC transporter AW20_2399 ENOG4105E5Q amino acid AbC transporter AW20_2402 ENOG4105D2S major facilitator superfamily AW20_2403 ENOG410756H nucleotidyltransferase AW20_2407 ENOG4105BZU Histidine kinase AW20_2411 ENOG4106UIA AW20_2412 ENOG4106UIA AW20_2416 ENOG4108V5C ABC transporter AW20_2417 ENOG4105DQ5 transport system permease protein AW20_2418 ENOG4105EHG Permease protein AW20_2422 ENOG4105D3R alkyl hydroperoxide reductase AW20_2428 ENOG4105DFD Na H antiporter AW20_2429 ENOG4105DTQ mandelate racemase muconate lactonizing AW20_2432 ENOG4108W15 Protein of unknown function (DUF1456) AW20_2435 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AW20_2436 ENOG4105D9N nucleoside AW20_244 ENOG4105CUV Homoserine Kinase AW20_2440 ENOG4105KPY Small multidrug resistance protein AW20_2441 ENOG4105C26 Dehydrogenase AW20_2443 ENOG4108JPW Aminotransferase AW20_2444 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AW20_2445 ENOG4105CBD Diacylglycerol kinase AW20_2450 ENOG410834F Transcriptional regulator AW20_2451 ENOG4105D0U Arsenite-activated ATPase (ArsA) AW20_2455 ENOG4105D01 (LipO)protein AW20_2456 ENOG4108UMI ABC transporter, permease AW20_2457 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AW20_2458 ENOG4108W2Y isochorismatase AW20_2464 ENOG4105C4R Atp-dependent dna helicase AW20_2469 ENOG4105C12 Phosphoribosylglycinamide synthetase AW20_2471 ENOG4108V3E phosphoribosylglycinamide formyltransferase AW20_2476 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AW20_2478 ENOG4105C83 adenylosuccinate lyase AW20_2479 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AW20_248 ENOG4107Y80 Major Facilitator superfamily AW20_2480 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AW20_2485 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW20_2489 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AW20_2494 ENOG4108SHN Glycosyl transferase, family 2 AW20_250 ENOG4105FQP Beta-lactamase AW20_2500 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AW20_2507 ENOG4105BZU Histidine kinase AW20_2509 ENOG4105C7N Xanthine uracil vitamin C permease AW20_2513 ENOG4108TYN CAAX amino terminal protease family protein AW20_2516 ENOG4105C5H ABC transporter AW20_2518 ENOG410801F ribosomal-protein-alanine acetyltransferase AW20_2519 ENOG41072GX Peptidase M22 Glycoprotease AW20_2520 ENOG4105K8N protein family UPF0079, ATPase AW20_253 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AW20_253 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AW20_2540 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AW20_2542 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AW20_2543 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AW20_2546 ENOG4107ZXI Rhomboid family AW20_2548 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AW20_2549 ENOG4105CPF Cell wall formation (By similarity) AW20_2550 ENOG4105CPF Cell wall formation (By similarity) AW20_2551 ENOG4108SC4 )-transporter AW20_2553 ENOG4105ERH Fumarylacetoacetate hydrolase AW20_2554 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AW20_2558 ENOG4108JQ7 (ABC) transporter AW20_2559 ENOG410667J hydrolase AW20_2560 ENOG4105C3U ABC transporter AW20_2561 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW20_2563 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AW20_2566 ENOG4105C5H ABC transporter AW20_2570 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AW20_2571 ENOG4108RE7 deoxyribonuclease AW20_2574 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AW20_2578 ENOG4105F6E Acyl-transferase AW20_2582 ENOG4105EGI Transcriptional regulator AW20_2585 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AW20_2586 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AW20_2587 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AW20_2588 ENOG4105E0C molybdate abc transporter AW20_2590 ENOG4107XDY Nicotinamide Mononucleotide Transporter AW20_2591 ENOG4105II7 pyrroline-5-carboxylate reductase AW20_2593 ENOG4108J59 Extracellular solute-binding protein, family 5 AW20_2594 ENOG4108J59 Extracellular solute-binding protein, family 5 AW20_2600 ENOG4108JQ7 (ABC) transporter AW20_2601 ENOG4105C3U ABC transporter AW20_2602 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW20_2603 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW20_2606 ENOG4105C2C drug resistance transporter, Bcr CflA AW20_2609 ENOG4105IQ5 FAD linked oxidase domain protein AW20_2612 ENOG4105D01 (LipO)protein AW20_2613 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AW20_2614 ENOG4108UMI ABC transporter, permease AW20_2615 ENOG4108PSK reductase AW20_262 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AW20_2623 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AW20_2624 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AW20_2626 ENOG4105CMG Carbohydrate kinase AW20_2627 ENOG4105CMG Carbohydrate kinase AW20_2629 ENOG4108VQT Alpha beta hydrolase fold protein AW20_2630 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AW20_2632 ENOG4107U5W ybbr family AW20_2633 ENOG4105C8B TIGR00159 family AW20_264 ENOG4105T9C HD domain AW20_2651 ENOG4108NMV polysaccharide deacetylase AW20_2654 ENOG4105D1F ATP-binding protein AW20_2660 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AW20_2669 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AW20_2671 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AW20_2697 ENOG4105XPM ribosomal protein AW20_2698 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AW20_27 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AW20_2700 ENOG4107Y49 methyltransferase AW20_2705 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AW20_2707 ENOG4105QIV RNA polymerase AW20_2708 ENOG4105M0M Tetracycline resistance protein AW20_2709 ENOG4105C2N RNA methyltransferase TrmH family group 3 AW20_271 ENOG4105DBI uridine monophosphokinase AW20_2712 ENOG4105D7W serine acetyltransferase AW20_2716 ENOG4105CTP PilT protein domain protein AW20_2718 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AW20_272 ENOG4105WCN acetyltransferase AW20_2721 ENOG4108Z0C Uvrb UvrC protein AW20_2728 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AW20_2730 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AW20_2731 ENOG4105KRF dihydroneopterin aldolase AW20_2732 ENOG4105EEI dihydropteroate synthase AW20_2733 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AW20_2734 ENOG4105DDQ anthranilate synthase AW20_2735 ENOG4105CRQ synthase (Component I) AW20_2736 ENOG4105C6T cysteine synthase AW20_2739 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AW20_274 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AW20_2740 ENOG4108UGV hypoxanthine phosphoribosyltransferase AW20_2741 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AW20_2745 ENOG41060GV RNA binding s1 domain protein AW20_2748 ENOG4105VYY sporulation protein yabp AW20_2749 ENOG41082I2 s4 domain protein AW20_275 ENOG4107QX3 carboxylase AW20_2750 ENOG4108IY2 MazG family AW20_2752 ENOG4108M14 stage v sporulation protein t AW20_2753 ENOG4108JA2 transcriptioN-repair coupling factor AW20_2759 ENOG4105KME endoribonuclease L-psp AW20_276 ENOG4105E39 Enoyl-CoA hydratase AW20_2760 ENOG4105DFT pur operon repressor AW20_2763 ENOG4105W42 Veg protein AW20_2764 ENOG4105XFA sporulation peptidase YabG AW20_2766 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AW20_2767 ENOG4105F8V Hydrolase, tatD family AW20_2769 ENOG4105KRN Transcriptional regulator, abrb family AW20_277 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AW20_2770 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AW20_2772 ENOG41060K3 Methyltransferase AW20_2774 ENOG4105MA4 psp1 domain protein AW20_2775 ENOG4105FA2 dna polymerase iii AW20_2777 ENOG4105CXN decarboxylase AW20_278 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AW20_2785 ENOG41067KS pro-sigma K processing AW20_2789 ENOG4105C6E dna polymerase iii AW20_279 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AW20_2790 ENOG4108Z6B deaminase AW20_2791 ENOG4105GTG Isochorismatase AW20_2793 ENOG4105ZMH deoxynucleoside kinase AW20_280 ENOG4105C1G acyl-Coa dehydrogenase AW20_2800 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AW20_2808 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW20_2811 ENOG410848D S4 domain protein YaaA AW20_2812 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AW20_2816 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AW20_2822 ENOG4107QJE Chromosome Partitioning Protein AW20_2823 ENOG4105FA0 parb-like partition protein AW20_2824 ENOG4108ZDA Sporulation protein YyaC AW20_2825 ENOG4105D8X mechanosensitive ion channel AW20_2826 ENOG4105VDK protein, conserved in bacteria AW20_2827 ENOG4105C3G gtp-binding protein AW20_2829 ENOG4108UUM single-stranded DNA-binding protein AW20_283 ENOG4107Z3H Transcriptional regulator, TetR family AW20_2831 ENOG4108XMW Membrane AW20_2832 ENOG4105BZR domain protein AW20_2834 ENOG4105CDU Replicative dna helicase AW20_2840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_2841 ENOG4105BZU Histidine kinase AW20_2844 ENOG4105Q2H domain protein AW20_2845 ENOG4105C0H protease AW20_2849 ENOG4105DPN Oligoendopeptidase f AW20_285 ENOG4105CJ1 ABC, transporter AW20_2852 ENOG4105C1J atp-dependent rna helicase AW20_2854 ENOG4108UT2 hemolysin iii AW20_2855 ENOG4105CMR udp-glucose 4-epimerase AW20_2857 ENOG4105IW1 AmiS UreI transporter AW20_2859 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW20_2862 ENOG4107RGD Major Facilitator superfamily AW20_2863 ENOG4108HRK Histidine kinase AW20_2864 ENOG4105DY9 regulatoR AW20_2867 ENOG4106F5Q Membrane AW20_2868 ENOG4105E0X reductase AW20_2870 ENOG41067SE Tetr family transcriptional regulator AW20_2871 ENOG4105CKK Glycosyl transferase, family 2 AW20_2877 ENOG4105C5H ABC transporter AW20_2878 ENOG4105JEU Glycosyl transferase, family 2 AW20_288 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AW20_2880 ENOG4108S4H thioesterase Superfamily protein AW20_2882 ENOG4106YBV Methyl-accepting chemotaxis AW20_2883 ENOG4105EN6 Membrane AW20_2887 ENOG41079KZ Major Facilitator Superfamily AW20_2888 ENOG4105DY9 regulatoR AW20_2889 ENOG4105D22 carbon starvation protein AW20_289 ENOG4105CEP NADH dehydrogenase AW20_2890 ENOG4105VCD cytoplasmic protein AW20_2891 ENOG4105BZU Histidine kinase AW20_2892 ENOG4105DWF phosphomethylpyrimidine kinase AW20_2893 ENOG4105BZU Histidine kinase AW20_2894 ENOG4105BZU Histidine kinase AW20_2895 ENOG4105WH1 Two component transcriptional regulator luxr family AW20_2897 ENOG4108Y4K DNA-binding transcriptional activator AW20_290 ENOG4106ANW SMI1_KNR4 AW20_2902 ENOG4105D6E homoserine dehydrogenase AW20_2905 ENOG41090WU lipolytic protein G-D-S-L family AW20_2906 ENOG4105CJ1 ABC, transporter AW20_2907 ENOG4108TU7 Inherit from COG: (ABC) transporter AW20_2909 ENOG4105VCH membrane AW20_2910 ENOG410667J hydrolase AW20_2917 ENOG4108VKI Cell wall hydrolase AW20_292 ENOG4105BZU Histidine kinase AW20_2920 ENOG4108IJ2 phosphate acetyltransferase AW20_2923 ENOG4108VCI transcription factor, rsfa family AW20_2925 ENOG4105DQ5 transport system permease protein AW20_2926 ENOG4105DQ5 transport system permease protein AW20_2927 ENOG4105EHG Permease protein AW20_2928 ENOG4105E0A ABC, transporter AW20_2929 ENOG4108MES Periplasmic binding protein AW20_2930 ENOG4105DCI Phosphohydrolase AW20_2931 ENOG41069HH 4-oxalocrotonate tautomerase AW20_2932 ENOG4108Z4T Peptidase M50 AW20_2933 ENOG4108XFG YwhD family AW20_2934 ENOG4105BZ4 penicillin-binding protein AW20_2935 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AW20_2936 ENOG4107SWG transcriptional regulator MERR family AW20_2937 ENOG4105DXB Major Facilitator superfamily AW20_2939 ENOG4105CYW agmatinase AW20_294 ENOG4105C5H ABC transporter AW20_2943 ENOG410684U Domain of unknown function (DUF1934) AW20_2945 ENOG4105EMN RNA polymerase sigma factor AW20_2949 ENOG4105IIU Aminopeptidase AW20_295 ENOG41067SE Tetr family transcriptional regulator AW20_2953 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AW20_2954 ENOG4108M15 ABC transporter AW20_2955 ENOG4105KCT ABC transporter AW20_2956 ENOG4105BZU Histidine kinase AW20_2961 ENOG4105BZU Histidine kinase AW20_2964 ENOG4105DF6 Fe-S oxidoreductase AW20_2966 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AW20_2967 ENOG4105C1G acyl-Coa dehydrogenase AW20_2968 ENOG4105C1G acyl-Coa dehydrogenase AW20_2976 ENOG4105CBT Fructose-1,6-bisphosphatase AW20_2977 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AW20_2981 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AW20_2982 ENOG4108ZXQ stage ii sporulation protein r AW20_2984 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AW20_2987 ENOG4107XC4 flavin reductase domain protein, FMN-binding AW20_2988 ENOG4108VGI doxx family AW20_2991 ENOG4108YZG isomerase AW20_2996 ENOG41062M3 atp synthase AW20_2997 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AW20_300 ENOG4108VXD carboxy-peptidase AW20_3007 ENOG4105BZU Histidine kinase AW20_3010 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AW20_3011 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AW20_3016 ENOG4105D65 subunit l AW20_3017 ENOG4105C8S subunit m AW20_3018 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AW20_3019 ENOG4106778 Protein of unknown function (DUF1146) AW20_3023 ENOG4108IUW ABC transporter AW20_3024 ENOG4105DY9 regulatoR AW20_3027 ENOG4105FRN stage II sporulation protein AW20_3029 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AW20_303 ENOG4105VZ8 Transcriptional regulator AW20_3039 ENOG4105EY8 ABC transporter AW20_3040 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AW20_3043 ENOG4105CMR udp-glucose 4-epimerase AW20_3044 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_3045 ENOG4105BZU Histidine kinase AW20_3048 ENOG4105CXY transporter AW20_3052 ENOG4105C19 ABC transporter AW20_3053 ENOG4107RBB ABC transporter, permease AW20_3055 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_3061 ENOG4105C0D helicase AW20_3062 ENOG4105KBK Zinc finger, swim domain protein AW20_3067 ENOG41069ER domain protein AW20_3068 ENOG4105C94 Transporter AW20_3077 ENOG4105E0M Sulfatase AW20_308 ENOG4105CGH 5'-nucleotidase AW20_3080 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AW20_3082 ENOG4105DAA L-lactate AW20_3091 ENOG4107RSM transcriptional regulator AW20_3092 ENOG4105ECB domain protein AW20_3093 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AW20_3096 ENOG4105VZJ PTS System AW20_3098 ENOG4105VCP PTS System AW20_3099 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AW20_3100 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AW20_3102 ENOG4105CK1 PTS System AW20_3103 ENOG4105VCP PTS System AW20_3104 ENOG4105F8D glycoside hydrolase family 4 AW20_3105 ENOG410901P UPF0249 protein AW20_3108 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AW20_3110 ENOG4105ESV Glycosyl transferase, family 4 AW20_3111 ENOG4105C6Y Udp-glucose 6-dehydrogenase AW20_3112 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AW20_3113 ENOG4108KGH TRANSCRIPTIONal AW20_3114 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AW20_3116 ENOG4105KVH Transcriptional regulator AW20_3119 ENOG41081UC Inherit from COG: Competence protein AW20_312 ENOG4105DH8 myo-inositol catabolism AW20_3120 ENOG4105VEQ Cold shock protein AW20_3121 ENOG4105MS2 ribosomal subunit Interface protein AW20_3122 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AW20_3123 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AW20_3125 ENOG4105CAK Cell division ATP-binding protein ftsE AW20_3126 ENOG4105CRP Part of the ABC transporter FtsEX involved in AW20_3127 ENOG4105CN1 protease AW20_3129 ENOG4105BZ1 (ABC) transporter AW20_313 ENOG4105D2N Aldolase AW20_3132 ENOG4108WS4 fmn reductase AW20_3134 ENOG4105DUM transcriptional regulator, lysR family AW20_3135 ENOG4105HMI Membrane AW20_3139 ENOG4107TXC Transcriptional regulator AW20_3142 ENOG4105D7V transposase AW20_3143 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AW20_3144 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AW20_3146 ENOG41086DT Membrane protein of unknown function AW20_3150 ENOG4108S4C acetyltransferase AW20_3152 ENOG4105C3M thioredoxin reductase AW20_3154 ENOG4108Z4K mutator MutT protein AW20_3156 ENOG4105CHW UPF0052 protein AW20_3158 ENOG4105KRI phosphocarrier protein (HPr AW20_3159 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AW20_3160 ENOG4105H67 Protein of unknown function (DUF421) AW20_3163 ENOG4105CZ3 stage V sporulation protein ad AW20_3164 ENOG41090VF Stage v sporulation protein ac AW20_3168 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_3173 ENOG4105CP7 Triose-phosphate isomerase AW20_3174 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AW20_3176 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW20_3181 ENOG4105EFC phage portal protein HK97 family AW20_319 ENOG4105CK5 oxidoreductase AW20_320 ENOG4105IE8 Alpha-ketoglutarate permease AW20_3200 ENOG41067MG lrgb family AW20_3201 ENOG4105XZU Preprotein translocase, subunit SecG AW20_3203 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AW20_3205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_3208 ENOG4105CM4 permease protein AW20_3209 ENOG4108IPW abc transporter atp-binding protein AW20_321 ENOG4105ETE Transcriptional regulator (LacI family AW20_3213 ENOG4108MK9 spermidine N(1)-acetyltransferase AW20_3216 ENOG4105WMR Protein CrcB homolog AW20_3217 ENOG4105WMR Protein CrcB homolog AW20_3219 ENOG4105C8Q Methyl-accepting chemotaxis AW20_322 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AW20_3221 ENOG4105D4A Cell wall formation (By similarity) AW20_3222 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AW20_3225 ENOG4105KVH Transcriptional regulator AW20_3226 ENOG4105F27 Major Facilitator AW20_3227 ENOG4105CV8 reductase AW20_3232 ENOG4108RYK Nad-dependent epimerase dehydratase AW20_3235 ENOG4105D9N nucleoside AW20_3236 ENOG4105D9N nucleoside AW20_324 ENOG4107RF6 penicillin-binding protein AW20_3241 ENOG4108URH decarboxylase AW20_3244 ENOG4108RMU ferritin dps family protein AW20_3246 ENOG4105NCW Trka-c domain protein AW20_3247 ENOG4107S91 Sodium hydrogen exchanger AW20_325 ENOG4107RF6 penicillin-binding protein AW20_3251 ENOG4105D4Y metalloprotease AW20_3252 ENOG4105VG1 fes assembly suf system protein AW20_3257 ENOG4105BZU Histidine kinase AW20_3258 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_3259 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AW20_326 ENOG4107RF6 penicillin-binding protein AW20_3261 ENOG4107ZTW SNARE associated Golgi AW20_3268 ENOG4107AYK membrAne AW20_3270 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AW20_3272 ENOG4107R7I amino acid AW20_3273 ENOG4108SUT Major Facilitator Superfamily AW20_3277 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AW20_3281 ENOG4105DZ1 carboxypeptidase AW20_3284 ENOG4105CHU acetyl-coa acetyltransferase AW20_3285 ENOG4105C1G acyl-Coa dehydrogenase AW20_3286 ENOG4108W8B Beta-lactamase domain protein AW20_3292 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AW20_3301 ENOG41080E8 Transcriptional regulator, Spx MgsR family AW20_3307 ENOG4108UMI ABC transporter, permease AW20_3308 ENOG4105D01 (LipO)protein AW20_3309 ENOG4105D01 (LipO)protein AW20_3310 ENOG4105C3K feS assembly ATPase SufC AW20_3311 ENOG4105JRK feS assembly protein SufD AW20_3312 ENOG4105C9B Cysteine desulfurase AW20_3313 ENOG4108UNV SUF system FeS assembly protein, NifU family AW20_3314 ENOG4105DIW FeS assembly protein SUFB AW20_3317 ENOG4107R8B 5'-nucleotidase AW20_3318 ENOG4105KZD Domain of unknown function (DUF1805) AW20_332 ENOG4105CIN aminoacyl-histidine dipeptidase AW20_3320 ENOG4105FAA peptidase M23 AW20_3325 ENOG41090T1 Membrane AW20_3326 ENOG4107TXC Transcriptional regulator AW20_3327 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AW20_3328 ENOG4105MMD transcriptional regulator AW20_3331 ENOG4105CBT Fructose-1,6-bisphosphatase AW20_3334 ENOG4105D4U had-superfamily hydrolase, subfamily iia AW20_3335 ENOG4105DYS nad(p)h dehydrogenase (quinone) AW20_3337 ENOG4108W5N phosphatidylglycerophosphatase a AW20_3340 ENOG41083MR nifu domain-containing protein AW20_3349 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AW20_3350 ENOG4105C4B ABC transporter, permease AW20_3351 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AW20_3355 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AW20_3358 ENOG4105EWC Purine nucleoside phosphorylase AW20_3364 ENOG4105CEP NADH dehydrogenase AW20_3367 ENOG41069ER domain protein AW20_3371 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AW20_3375 ENOG4105KA0 thioesterase Superfamily protein AW20_3379 ENOG4107R3E Citrate transporter AW20_3381 ENOG4105Y38 Kinase-associated protein B AW20_3384 ENOG4105C87 Aminotransferase class I and II AW20_3386 ENOG4108MUZ hydrolase AW20_3387 ENOG4105C5I Dehydrogenase AW20_3388 ENOG4108ZB6 transcriptional regulator AsnC family AW20_3389 ENOG4105CHM Aminotransferase AW20_3391 ENOG4105WG9 Conserved Protein AW20_3392 ENOG4107QYV phosphohexose isomerase AW20_3393 ENOG4107PBV potassium channel AW20_3395 ENOG4105KT7 mgtC SapB transporter AW20_340 ENOG41090HR transcriptional regulator AW20_3403 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AW20_341 ENOG4107RA9 decarboxylase AW20_342 ENOG4108I0C methyltransferase AW20_3426 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AW20_3431 ENOG4105VEQ Cold shock protein AW20_3433 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AW20_3434 ENOG4105E4F Isochorismate synthase AW20_3435 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AW20_3436 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AW20_3437 ENOG4108IPT Naphthoate synthase AW20_3439 ENOG4105DTQ mandelate racemase muconate lactonizing AW20_344 ENOG41088CC tellurite resistance protein tehB AW20_3445 ENOG41069H0 dihydroorotase EC 3.5.2.3 AW20_3450 ENOG4105C6Z Gluconate AW20_3461 ENOG41086D8 Transcriptional regulator AW20_3462 ENOG4105C19 ABC transporter AW20_3465 ENOG4107ZTW SNARE associated Golgi AW20_3472 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AW20_3473 ENOG4108UGV hypoxanthine phosphoribosyltransferase AW20_3478 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_3479 ENOG4105BZU Histidine kinase AW20_348 ENOG4108RZE Tetr family transcriptional regulator AW20_3486 ENOG41087YS Phage shock protein A AW20_3495 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AW20_3496 ENOG4105C4M (Ubiquinol oxidase) subunit I AW20_3498 ENOG4108V2W Carbonate dehydratase AW20_350 ENOG4105C1J atp-dependent rna helicase AW20_3505 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AW20_3509 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AW20_3511 ENOG4105D2X ABC transporter substrate-binding protein AW20_3515 ENOG4107T7U Sulfatase AW20_3516 ENOG4107S9D Alpha beta hydrolase AW20_3517 ENOG4105BZU Histidine kinase AW20_3518 ENOG4105BZU Histidine kinase AW20_3519 ENOG4105EGD dinuclear metal center protein, YbgI family AW20_3529 ENOG4108RIR Molybdenum cofactor biosynthesis protein AW20_353 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AW20_3531 ENOG4105BZF Glycosyl transferase (Group 1 AW20_3532 ENOG4105YVM Phosphoesterase, PA-phosphatase related AW20_3533 ENOG4108Z0R Transferase AW20_3534 ENOG4105E8V Alpha Beta Hydrolase Fold protein AW20_3540 ENOG4105DA5 (ABC) transporter AW20_3542 ENOG4105N5T Radical SAM Protein AW20_3546 ENOG4105C19 ABC transporter AW20_3549 ENOG4105NCW Trka-c domain protein AW20_3550 ENOG4107S91 Sodium hydrogen exchanger AW20_3551 ENOG410605W Major Facilitator AW20_3557 ENOG4108B31 Spore germination protein AW20_3559 ENOG4105DWV Homoserine O-trans-acetylase AW20_356 ENOG4107STF Involved in phosphonate degradation (By similarity) AW20_3561 ENOG41085GJ domain protein AW20_3565 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AW20_3566 ENOG4105D06 uba thif-type nad fad binding protein AW20_3568 ENOG4105CVM Molybdenum cofactor synthesis domain protein AW20_3569 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AW20_3570 ENOG4108ZAF Molybdopterin AW20_3573 ENOG4105CSC Glucose uptake protein AW20_3574 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AW20_3575 ENOG4108VJ1 Transcriptional regulator (CarD family AW20_358 ENOG4105RD7 BadF BadG BcrA BcrD AW20_3582 ENOG4105CBX hi0933 family AW20_3585 ENOG4105YW5 deoR family transcriptional regulator AW20_3586 ENOG4107QSE Dipeptidase AW20_3587 ENOG4107QSE Dipeptidase AW20_3589 ENOG4108IUM Glycogen debranching enzyme AW20_3590 ENOG4108V15 phosphotransferase enzyme family AW20_3593 ENOG4105C8F Beta-lactamase domain protein AW20_3599 ENOG4108VDD TRNA binding domain protein AW20_36 ENOG4108M1A Chitin-binding protein AW20_3608 ENOG4105C88 aminopeptidase AW20_3612 ENOG4105ETE Transcriptional regulator (LacI family AW20_3618 ENOG4105EP9 oxidoreductase AW20_3619 ENOG4107SNB ankyrin repeat protein YahD AW20_3621 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW20_3623 ENOG4105DGU Histone deacetylase AW20_3624 ENOG4105W87 Cbs domain AW20_3625 ENOG4105F1V Acetoin utilization protein AW20_3628 ENOG4105EMN RNA polymerase sigma factor AW20_363 ENOG4105F32 YngK protein AW20_3634 ENOG4105C28 cystathionine AW20_3636 ENOG4105U5Y Transcriptional regulator AW20_3637 ENOG4105U5Y Transcriptional regulator AW20_3639 ENOG4106KR7 LysR family Transcriptional regulator AW20_3644 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AW20_3646 ENOG4105EFZ amidohydrolase AW20_3649 ENOG4105KBJ sporulation protein ytfj AW20_3650 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AW20_3652 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AW20_3656 ENOG4108JYZ YitT family AW20_3665 ENOG4107YZX Universal stress protein AW20_3669 ENOG4105VZ8 Transcriptional regulator AW20_3671 ENOG41082W1 Cupin 2, conserved barrel domain protein AW20_3672 ENOG4105Z7P Acetyltransferase (GNAT) family AW20_3679 ENOG4105DC7 peptidase M24 AW20_368 ENOG4108KPJ rna polymerase sigma factor AW20_3686 ENOG4105SFS phosphoesterase RecJ domain protein AW20_3688 ENOG4105VV2 AW20_3689 ENOG4105C0B DNA polymerase III (alpha subunit) AW20_369 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B AW20_3690 ENOG4105C6K Malic enzyme AW20_3691 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AW20_3696 ENOG4105FS0 cytoplasmic membrane protein AW20_3697 ENOG4108REF Sporulation integral membrane protein ytvi AW20_3699 ENOG4105BZN citrate synthase AW20_37 ENOG41082BV acetyltransferase AW20_3700 ENOG4108HMX isocitrate dehydrogenase (NADP) AW20_3704 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW20_3705 ENOG4105BZU Histidine kinase AW20_3706 ENOG4105C2M dna polymerase I AW20_3709 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AW20_3710 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AW20_3715 ENOG4108TDW sporulation protein YtxC AW20_3716 ENOG4105C22 threonyL-tRNA synthetase AW20_3721 ENOG4105CN9 Peptidase m42 family protein AW20_3722 ENOG4108JGH Tetr family transcriptional regulator AW20_3723 ENOG4105CW7 secretion protein, HlyD family AW20_3724 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW20_373 ENOG4108JCI Transcriptional regulator AW20_3731 ENOG4108RWN rrna methyltransferase AW20_3741 ENOG4105DCG PHP domain protein AW20_3742 ENOG4105DCG PHP domain protein AW20_3745 ENOG4105FE9 pseudouridine synthase AW20_3747 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AW20_3749 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AW20_3752 ENOG4105E0A ABC, transporter AW20_3753 ENOG4105KFN sortase, SrtB family AW20_3756 ENOG4105DR4 Methyltransferase AW20_3759 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW20_3768 ENOG4105S6R Iron-hydroxamate transporter permease subunit AW20_3769 ENOG4105J76 Periplasmic binding protein AW20_377 ENOG4105BZ1 (ABC) transporter AW20_3771 ENOG4105CEY Amp-dependent synthetase and ligase AW20_3772 ENOG4107Z3H Transcriptional regulator, TetR family AW20_3773 ENOG41060WC Enoyl-CoA hydratase AW20_3774 ENOG4105BZJ Electron transfer flavoprotein AW20_3775 ENOG4105C10 Electron transfer flavoprotein AW20_3776 ENOG4105K63 Thioredoxin AW20_3779 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AW20_378 ENOG4105BZ1 (ABC) transporter AW20_3781 ENOG4105E33 succinate dehydrogenase AW20_3783 ENOG4108VXD carboxy-peptidase AW20_3784 ENOG4105E14 MotA TolQ exbB proton channel AW20_3785 ENOG4105ER2 Ompa motb domain protein AW20_3786 ENOG4105ER2 Ompa motb domain protein AW20_3787 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AW20_3788 ENOG4108IUX (ABC) transporter AW20_3789 ENOG4105RHA ABC transporter, permease AW20_3790 ENOG4108Z40 Transcriptional regulator AW20_3791 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AW20_3793 ENOG4108JCI Transcriptional regulator AW20_3794 ENOG41067S9 phage shock protein C, PspC AW20_3797 ENOG4105DY9 regulatoR AW20_3798 ENOG4108HRK Histidine kinase AW20_3799 ENOG4108JQ7 (ABC) transporter AW20_38 ENOG4105E66 phosphoriboisomerase A AW20_3802 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW20_3803 ENOG4105DEF Extracellular solute-binding protein, family 5 AW20_3804 ENOG4105DZC cytosine deaminase AW20_3805 ENOG4105DZC cytosine deaminase AW20_3808 ENOG4105PFC Transcriptional regulator AW20_381 ENOG4108RPX mosc domain containing protein AW20_3811 ENOG4105KBX Transcriptional regulator, TetR family AW20_3813 ENOG4108PCX Major Facilitator AW20_3815 ENOG4108XJQ germination protein AW20_3818 ENOG4105M59 Phosphodiesterase, mj0936 family AW20_382 ENOG4105DND Transcriptional regulator AW20_3822 ENOG4108QCI YvbH-like oligomerisation region AW20_3828 ENOG4108IUQ atp-dependent protease AW20_3832 ENOG4105K56 Transcriptional regulator AW20_3837 ENOG4105D52 delta-aminolevulinic acid dehydratase AW20_3839 ENOG41068KH stage VI sporulation protein D AW20_3841 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AW20_3842 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AW20_3846 ENOG4105DFF Rod shape-determining protein mreb AW20_385 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AW20_3850 ENOG4107QMS site-determining protein AW20_3853 ENOG4105C03 ribonuclease AW20_3855 ENOG4105X36 (ribosomal) protein AW20_3858 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AW20_386 ENOG4107V2S Transcriptional regulator AW20_3861 ENOG4105EWM Histidine kinase AW20_3865 ENOG4105CQC Prephenate dehydratase AW20_3866 ENOG4108RPX mosc domain containing protein AW20_3869 ENOG4108IYU L-aspartate oxidase AW20_3870 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AW20_3875 ENOG41082BM Transcriptional regulator, arsr family AW20_3876 ENOG4108IPJ Membrane AW20_3877 ENOG4108IPJ Membrane AW20_3879 ENOG4108HUF Transporter AW20_3882 ENOG41061AI Protein of unknown function (DUF2905) AW20_3885 ENOG4105VIE preprotein translocase, subunit YajC AW20_3887 ENOG4108QG2 Membrane AW20_3888 ENOG4105CKP Polysaccharide Biosynthesis Protein AW20_3890 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AW20_3891 ENOG41076HS cation diffusion facilitator family transporter AW20_3892 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AW20_3894 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AW20_3899 ENOG4105CUZ uba thif-type nad fad binding protein AW20_3900 ENOG4105D1H recombination factor protein RarA AW20_3902 ENOG4105C3J Cysteine desulfurase AW20_3903 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AW20_3905 ENOG4105C7H Helicase, RecD TraA family AW20_3906 ENOG41060CR AW20_3909 ENOG4105C02 permease AW20_3911 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AW20_3915 ENOG4105HHA aminodeoxychorismate lyase AW20_3917 ENOG4105XYU peptidase (U32 family) AW20_3918 ENOG4105CFP Peptidase U32 AW20_3921 ENOG4107XRG penicillin-binding protein AW20_3927 ENOG4105C28 cystathionine AW20_3928 ENOG4105C0A alcohol dehydrogenase AW20_3930 ENOG4108V5C ABC transporter AW20_3931 ENOG4105S6R Iron-hydroxamate transporter permease subunit AW20_3939 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AW20_394 ENOG410667J hydrolase AW20_3940 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AW20_3942 ENOG4105MIR Phenylalanine 4-monooxygenase AW20_3943 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AW20_3950 ENOG4108MUZ hydrolase AW20_3952 ENOG4105G6Z alkaline phosphatase AW20_3955 ENOG4108TVJ Nitroreductase AW20_3960 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_3963 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AW20_3964 ENOG4105CQW ribosome biogenesis GTPase YqeH AW20_3966 ENOG410812S Rna-binding protein AW20_3968 ENOG4108WF2 Metal Dependent Phosphohydrolase AW20_3970 ENOG4105DXX methyltransferase AW20_3972 ENOG4105KQC Competence protein AW20_3973 ENOG4108UK2 deaminase AW20_3974 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AW20_3976 ENOG4105TQK DNA polymerase iii, delta' subunit AW20_398 ENOG4105VEQ Cold shock protein AW20_3981 ENOG4105KVH Transcriptional regulator AW20_3982 ENOG4105CSA Coproporphyrinogen iii oxidase AW20_3988 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AW20_3989 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AW20_3991 ENOG4105KTH gatB Yqey AW20_3992 ENOG41068P3 sporulation protein YqfC AW20_3994 ENOG4105C9A Phoh family AW20_3995 ENOG4105CTJ Metal Dependent Phosphohydrolase AW20_3997 ENOG4107YR5 Diacylglycerol kinase AW20_3998 ENOG4105KG3 cytidine deaminase AW20_3999 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AW20_4 ENOG4108M1A Chitin-binding protein AW20_400 ENOG41068WN AW20_4004 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AW20_4006 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_4009 ENOG4105EGD dinuclear metal center protein, YbgI family AW20_4014 ENOG41069ZM Protein of unknown function (DUF2624) AW20_4015 ENOG4108JYZ YitT family AW20_4016 ENOG4105FDK ABC transporter AW20_4018 ENOG4105N80 Ferric uptake regulator, Fur family AW20_402 ENOG4105C1Q protoporphyrinogen oxidase AW20_4023 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW20_4025 ENOG4107RF6 penicillin-binding protein AW20_4026 ENOG4105PWN phosphate abc transporter AW20_4027 ENOG4105C8U phosphate abc transporter AW20_4028 ENOG4105E2Z phosphate ABC transporter (Permease AW20_4030 ENOG4108UTW Plays a role in the regulation of phosphate uptake AW20_4033 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AW20_4035 ENOG4105DKQ ROK family AW20_4037 ENOG4105C5X domain protein AW20_4041 ENOG4105C28 cystathionine AW20_4042 ENOG4105C28 cystathionine AW20_4044 ENOG4105C3R Methionine synthase AW20_4045 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AW20_4069 ENOG4105C0D helicase AW20_4075 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AW20_4076 ENOG4105CJ1 ABC, transporter AW20_408 ENOG4105WCN acetyltransferase AW20_4083 ENOG41080TC multidrug resistance protein AW20_4087 ENOG4105WZW rhodanese family AW20_4088 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AW20_4093 ENOG4107YBY Hydrolase AW20_4094 ENOG4105CBJ Metal-dependent enzyme AW20_4097 ENOG4105DC7 peptidase M24 AW20_4102 ENOG4105CD2 stage iii sporulation protein aa AW20_4103 ENOG4105KR5 Stage iii sporulation protein AW20_4104 ENOG4108CQH stage III sporulation protein AC AW20_4105 ENOG4105KQ4 Stage iii sporulation protein ad AW20_4107 ENOG410644B Stage III sporulation protein af AW20_4112 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AW20_4113 ENOG4108ZSR alkaline shock protein AW20_4118 ENOG4105CTB Polyprenyl synthetase AW20_4120 ENOG4105DX0 Hemolysin A AW20_4122 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AW20_4123 ENOG4105S1Z Stage IV sporulation protein B AW20_4124 ENOG4107QQR Sporulation AW20_4127 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AW20_4129 ENOG4108JUB Transcriptional regulator AW20_413 ENOG4105EYF MMPL domain protein AW20_4131 ENOG4107RDP Dehydrogenase AW20_4135 ENOG4105CPP Dehydrogenase, E1 component AW20_4136 ENOG4105C7S Dehydrogenase AW20_4138 ENOG4105E09 nadh pyrophosphatase AW20_4139 ENOG4105G7B Protein of unknown function (DUF2992) AW20_4141 ENOG4108HW3 (ABC) transporter AW20_4142 ENOG4105E5Q amino acid AbC transporter AW20_4143 ENOG4105CDA abc transporter atp-binding protein AW20_4144 ENOG4108QEG Membrane AW20_4145 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AW20_4147 ENOG4105D9U N-acetyltransferase AW20_4148 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AW20_415 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AW20_4150 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AW20_4154 ENOG4105EJQ L-serine dehydratase AW20_4155 ENOG4105II7 pyrroline-5-carboxylate reductase AW20_4158 ENOG41069FQ Metallo-beta-lactamase superfamily AW20_4159 ENOG4108IXY short-chain dehydrogenase reductase AW20_4162 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AW20_4170 ENOG4105CGH 5'-nucleotidase AW20_4171 ENOG4105DFD Na H antiporter AW20_4173 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW20_4176 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AW20_4177 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AW20_418 ENOG41081I9 integral membrane protein AW20_4182 ENOG4108R6K riboflavin synthase, subunit alpha AW20_4183 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AW20_4187 ENOG4108YM7 Gcn5-related n-acetyltransferase AW20_4188 ENOG4105ETE Transcriptional regulator (LacI family AW20_4190 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AW20_4194 ENOG4105RHY Pfam:UPF0157 AW20_4196 ENOG4105CPC Aldo Keto reductase AW20_4200 ENOG4105MZ9 stage II sporulation protein m AW20_4201 ENOG4105I3K Ferric uptake regulator, Fur family AW20_4203 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW20_4208 ENOG4105D7N magnesium and cobalt transport protein CorA AW20_4214 ENOG4105DVE abc transporter atp-binding protein AW20_4215 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AW20_4216 ENOG4105DZ1 carboxypeptidase AW20_4217 ENOG41082AN stage II sporulation protein AW20_4219 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_4220 ENOG4105C8J )-transporter AW20_4224 ENOG41090VF Stage v sporulation protein ac AW20_4225 ENOG4105CZ3 stage V sporulation protein ad AW20_4227 ENOG4105G6R Stage v sporulation protein ae AW20_4229 ENOG4105J7I hydrolase AW20_4230 ENOG4105PTM secreted protein AW20_4231 ENOG4107ZE5 PPIases accelerate the folding of proteins AW20_4238 ENOG4105CE4 GlcNAc 6-P deacetylase AW20_424 ENOG4108D32 Methyltransferase AW20_4242 ENOG4105CID antiterminator AW20_4250 ENOG4106TD9 Diguanylate cyclase AW20_4255 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AW20_4260 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AW20_4264 ENOG4105DTD Dehydrogenase AW20_4265 ENOG4105K7K Transcriptional regulator AW20_4272 ENOG4105CHU acetyl-coa acetyltransferase AW20_4281 ENOG4105CG3 alpha amylase, catalytic region AW20_4283 ENOG4107FKK extracellular solute-binding protein family 1 AW20_4285 ENOG4105EG2 ABC transporter, permease AW20_4286 ENOG4105FKQ transcriptional regulator AW20_4287 ENOG4105CHM Aminotransferase AW20_4289 ENOG4108HGU Histidine kinase AW20_43 ENOG4108IJ7 Glycine betaine AW20_430 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AW20_4300 ENOG4105UIN AW20_4302 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AW20_4305 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AW20_4306 ENOG4105EPM Diguanylate phosphodiesterase AW20_4309 ENOG4107IN1 Protein of unknown function (DUF1797) AW20_4311 ENOG4108XRC Protein of unknown function (DUF458) AW20_4318 ENOG4107ZYR domain protein AW20_4319 ENOG4105CN5 Metallo-Beta-Lactamase AW20_4321 ENOG4108X4Q Hydrolase AW20_4322 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AW20_4325 ENOG4105CPP Dehydrogenase, E1 component AW20_4326 ENOG4105C7S Dehydrogenase AW20_4335 ENOG4105CXN decarboxylase AW20_4339 ENOG4105ECY inositol monophosphatase AW20_434 ENOG4105C22 threonyL-tRNA synthetase AW20_4341 ENOG4105CI3 gtp-binding protein typa AW20_4342 ENOG4105QA2 AW20_4346 ENOG4108IAB Phoh family AW20_4349 ENOG4105CNI cell division protein FtsW AW20_435 ENOG4105FE9 pseudouridine synthase AW20_4350 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AW20_4360 ENOG4106UY4 Inherit from COG: Scp-like extracellular AW20_4363 ENOG4107TB6 phosphoglycerate mutase AW20_4368 ENOG4106H78 methyltransferase AW20_4369 ENOG4105H20 Sporulation integral membrane protein YlbJ AW20_4371 ENOG4105D78 K07001 NTE family protein AW20_4372 ENOG41063PX domain protein AW20_4374 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) AW20_4382 ENOG4108IMY Transcriptional regulator AW20_439 ENOG4105BZG amino acid carrier protein AW20_4393 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_44 ENOG4107SQ8 Glycine betaine AW20_4413 ENOG4105CAR Terminase, large subunit AW20_443 ENOG4105K70 DNA-binding protein AW20_4433 ENOG4105XSJ toxin secretion phage lysis holin AW20_4443 ENOG4105KNH Nucleic acid-binding protein AW20_4450 ENOG41068DC Essential cell division protein (By similarity) AW20_4451 ENOG4105CJN penicillin-binding protein AW20_4452 ENOG4105CJN penicillin-binding protein AW20_4453 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AW20_4456 ENOG4105CNI cell division protein FtsW AW20_4458 ENOG4105D4A Cell wall formation (By similarity) AW20_4459 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AW20_446 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW20_4460 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AW20_4461 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AW20_4463 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_4465 ENOG4105WR5 sporulation protein, YlmC YmxH family AW20_4466 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AW20_4467 ENOG4105DFA alanine racemase domain protein AW20_4469 ENOG41067XK integral membrane protein AW20_447 ENOG4105WQT MbtH domain protein AW20_4470 ENOG4105DBK s4 domain protein AW20_4475 ENOG4105C34 Pseudouridine synthase AW20_448 ENOG4105CEY Amp-dependent synthetase and ligase AW20_449 ENOG4105WQI isochorismatase AW20_4491 ENOG4105DC7 peptidase M24 AW20_4494 ENOG4105DSJ YicC domain protein AW20_4498 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AW20_4499 ENOG4105C25 Primosomal protein n' AW20_450 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AW20_4500 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AW20_4502 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AW20_4504 ENOG4108ZF3 Phosphatase AW20_4505 ENOG4105D9P serine threonine protein kinase AW20_4506 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AW20_4507 ENOG4105DJV ribulose-phosphate 3-epimerase AW20_4508 ENOG4105FJ0 thiamine AW20_451 ENOG4105E4F Isochorismate synthase AW20_4510 ENOG4108ZAA Alkaline-shock protein AW20_4511 ENOG4105DP4 dak2 domain fusion protein ylov AW20_4512 ENOG4105CB5 ATP-dependent DNA helicase recG AW20_4515 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AW20_4516 ENOG4105CHR reductase AW20_4519 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AW20_452 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AW20_4520 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AW20_4524 ENOG4105VB6 UPF0109 protein AW20_4529 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AW20_453 ENOG4105FCD Major Facilitator AW20_4532 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AW20_4534 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AW20_4536 ENOG4108HE4 integrase family AW20_4544 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AW20_4545 ENOG4105KNE Phosphatidate cytidylyltransferase AW20_4547 ENOG4105DZP Membrane-associated zinc metalloprotease AW20_4549 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AW20_4551 ENOG4105CHV Transcription elongation factor NusA AW20_4552 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AW20_4553 ENOG4105VHM ribosomal protein AW20_4555 ENOG4105W7A Protein of unknown function (DUF503) AW20_4557 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AW20_4558 ENOG4105DTN riboflavin biosynthesis protein ribF AW20_4562 ENOG4105C1V Peptidase, M16 AW20_4564 ENOG4105E35 Dipicolinate synthase subunit A AW20_4565 ENOG4108S0H Dipicolinic acid synthetase, b subunit AW20_4566 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AW20_4568 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AW20_457 ENOG4105EYH Exonuclease AW20_4570 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AW20_4572 ENOG4107QZI cell division protein FtsK AW20_4573 ENOG4105FDP GntR family transcriptional regulator AW20_4574 ENOG4105DIH basic membrane AW20_4575 ENOG4108JQ9 ABC transporter AW20_4576 ENOG4105UIB (ABC) transporter AW20_4577 ENOG4105UIB (ABC) transporter AW20_458 ENOG4107RFY SbcCD D subunit AW20_4581 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AW20_4582 ENOG4105XZV Protein of unknown function (DUF3243) AW20_4585 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AW20_4590 ENOG4105D48 metallophosphoesterase AW20_4591 ENOG4105MCT stage V sporulation protein S AW20_4592 ENOG4108IGT Dipeptidase AW20_4593 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AW20_4594 ENOG4105DQU oxidoreductase, subunit beta AW20_4595 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AW20_4600 ENOG4105DA5 (ABC) transporter AW20_4605 ENOG4107QHE Choloylglycine hydrolase AW20_4607 ENOG410890F Dynamin family AW20_4608 ENOG4105E0M Sulfatase AW20_4609 ENOG4107R6R udp-galactopyranose mutase AW20_461 ENOG4105E39 Enoyl-CoA hydratase AW20_4610 ENOG4105F0V Cell wall hydrolase AW20_4614 ENOG4107YEI lmbE family AW20_4615 ENOG4107TTQ Alpha beta hydrolase fold AW20_4618 ENOG41067MG lrgb family AW20_462 ENOG4105N14 lysine exporter protein LysE YggA AW20_4621 ENOG4105BZU Histidine kinase AW20_4622 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AW20_4628 ENOG4105D03 DNA-3-methyladenine glycosylase II AW20_4629 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AW20_4631 ENOG4105CGK Exodeoxyribonuclease III AW20_4636 ENOG4105E0A ABC, transporter AW20_4637 ENOG4105NIV Esterase AW20_4639 ENOG4105VPX protein, conserved in bacteria AW20_464 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AW20_4640 ENOG410681U heavy metal transport detoxification protein AW20_4641 ENOG4105C59 p-type ATPase AW20_4642 ENOG4105K70 DNA-binding protein AW20_4643 ENOG4105TMB Formate nitrite transporter AW20_4647 ENOG4105C85 amino acid AW20_465 ENOG4105C1G acyl-Coa dehydrogenase AW20_4650 ENOG4108SJC Membrane AW20_4651 ENOG4107QW4 alcohol dehydrogenase AW20_4652 ENOG4107QW4 alcohol dehydrogenase AW20_4653 ENOG4105E98 transcriptional regulator DeoR family AW20_4654 ENOG4105DE4 1-phosphofructokinase AW20_4655 ENOG4105DM4 PTS System AW20_4656 ENOG41069ER domain protein AW20_466 ENOG4105CR4 methylisocitrate lyase AW20_4663 ENOG4106F1P AAA ATPase, central domain protein AW20_4664 ENOG4105EN6 Membrane AW20_4665 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AW20_4666 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AW20_4667 ENOG4105CXI aluminum resistance protein AW20_4668 ENOG4105KV4 Transcriptional regulator AW20_4669 ENOG4105C5F glutamine synthetase AW20_467 ENOG4105DXD 2-methylcitrate dehydratase AW20_469 ENOG4105W8X HesB YadR YfhF-family protein AW20_4690 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) AW20_470 ENOG4105CZM Major Facilitator AW20_471 ENOG4105BZ4 penicillin-binding protein AW20_4730 ENOG4105XSJ toxin secretion phage lysis holin AW20_4731 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AW20_4739 ENOG4105K7K Transcriptional regulator AW20_4743 ENOG4108SVB resolvase AW20_4745 ENOG4105CGH 5'-nucleotidase AW20_4748 ENOG4105D5T phosphonate abc transporter AW20_4751 ENOG4105D7V transposase AW20_4755 ENOG4105BZ1 (ABC) transporter AW20_4756 ENOG4105BZ1 (ABC) transporter AW20_4759 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW20_4764 ENOG41067MG lrgb family AW20_4765 ENOG4105VAW lrga family AW20_4766 ENOG4107RSM transcriptional regulator AW20_4768 ENOG4107QIV Cytochrome c biogenesis protein AW20_4779 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AW20_4784 ENOG4108903 Formimidoylglutamase AW20_4785 ENOG4108VJ1 Transcriptional regulator (CarD family AW20_4786 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AW20_4787 ENOG4105CBC glutamate synthase AW20_4788 ENOG4105CK7 Sodium proline symporter AW20_4789 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AW20_479 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AW20_4790 ENOG4105FBA Phospholipase Carboxylesterase AW20_4791 ENOG4105BZU Histidine kinase AW20_4793 ENOG4107AYK membrAne AW20_4802 ENOG4105CEY Amp-dependent synthetase and ligase AW20_4803 ENOG4107ZYJ bioY protein AW20_4804 ENOG4107F3J Amp-dependent synthetase and ligase AW20_4808 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AW20_4810 ENOG4105E5W Transporter AW20_4815 ENOG4108I0Z Aconitate hydratase AW20_4816 ENOG4108JJA ABC, transporter AW20_4818 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AW20_4819 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AW20_4825 ENOG4105W8X HesB YadR YfhF-family protein AW20_4826 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AW20_4827 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AW20_4829 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_4830 ENOG4105C0H protease AW20_4831 ENOG4105K4P CoA-binding domain protein AW20_4832 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW20_4834 ENOG4105D9R oxidoreductase AW20_4836 ENOG4105CIG ABC transporter AW20_4840 ENOG4105EMN RNA polymerase sigma factor AW20_4842 ENOG4108KGH TRANSCRIPTIONal AW20_4843 ENOG4107QJT sodium dicarboxylate symporter AW20_4855 ENOG4105E1K spore germination protein AW20_4857 ENOG4108JB9 formate dehydrogenase AW20_4859 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AW20_4860 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AW20_4862 ENOG4105TMB Formate nitrite transporter AW20_4863 ENOG4105D06 uba thif-type nad fad binding protein AW20_4864 ENOG4105CVM Molybdenum cofactor synthesis domain protein AW20_4865 ENOG4108ZAF Molybdopterin AW20_4867 ENOG4105D1F ATP-binding protein AW20_4870 ENOG410696E Membrane AW20_4871 ENOG4105FR1 rard protein AW20_4873 ENOG4105EWU Squalene--hopene cyclase AW20_4875 ENOG4105CHR reductase AW20_4876 ENOG4105C26 Dehydrogenase AW20_4878 ENOG4108IA2 Sodium pantothenate symporter AW20_4881 ENOG4106IQC argininosuccinate lyase AW20_4883 ENOG410904N short-chain dehydrogenase reductase AW20_4887 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AW20_4891 ENOG4105VEQ Cold shock protein AW20_4895 ENOG4108R1P AW20_4897 ENOG41073R8 VanW family AW20_4898 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AW20_4900 ENOG4105KT7 mgtC SapB transporter AW20_4902 ENOG4105E39 Enoyl-CoA hydratase AW20_4903 ENOG4105K64 Glycosyl transferase, family 2 AW20_4905 ENOG4108UT6 Transferase hexapeptide repeat containing protein AW20_4909 ENOG4105CQB FAD linked oxidase domain protein AW20_4910 ENOG4105C09 Bile acid AW20_4912 ENOG4105RHY Pfam:UPF0157 AW20_4918 ENOG4105CIS alcohol dehydrogenase AW20_4919 ENOG41082BM Transcriptional regulator, arsr family AW20_4923 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AW20_4929 ENOG4108A04 Beta-lactamase AW20_4930 ENOG4105DPN Oligoendopeptidase f AW20_4931 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AW20_4932 ENOG4105E5K Alpha-amylase AW20_4934 ENOG4105C98 muts2 protein AW20_4938 ENOG4107V2S Transcriptional regulator AW20_4940 ENOG4107CUJ Protein of unknown function (DUF2690) AW20_4944 ENOG4107ZY0 Phenazine biosynthesis-like protein AW20_4945 ENOG4105NX3 Membrane AW20_4946 ENOG4105DQ5 transport system permease protein AW20_4947 ENOG4105EHG Permease protein AW20_4949 ENOG4108MES Periplasmic binding protein AW20_4953 ENOG4107R3E Citrate transporter AW20_4955 ENOG4108TN2 lmbE family AW20_4962 ENOG4105CIS alcohol dehydrogenase AW20_4963 ENOG4105CIS alcohol dehydrogenase AW20_4970 ENOG4105H3G oxidoreductase AW20_4977 ENOG4107YXZ hydrolase, family 25 AW20_498 ENOG4108IBT Inherit from COG: transposase AW20_4981 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AW20_4986 ENOG4105KAF membrAne AW20_50 ENOG4105RHY Pfam:UPF0157 AW20_500 ENOG4105SZ6 Thioredoxin AW20_5000 ENOG4105KVH Transcriptional regulator AW20_5001 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AW20_5005 ENOG4105CHR reductase AW20_5007 ENOG4105JAB phenazine biosynthesis protein, phzf family AW20_501 ENOG410841Q phosphoesterase PA-phosphatase related protein AW20_5014 ENOG4105KVH Transcriptional regulator AW20_5015 ENOG4105KVH Transcriptional regulator AW20_5016 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AW20_5018 ENOG4105D9R oxidoreductase AW20_5019 ENOG4108TZY GntR Family Transcriptional Regulator AW20_5020 ENOG4105KVH Transcriptional regulator AW20_5026 ENOG4105C44 Serine transporter AW20_5027 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AW20_503 ENOG4108N23 SpoOM-related protein AW20_5030 ENOG4105F27 Major Facilitator AW20_5031 ENOG4105CV8 reductase AW20_5035 ENOG4105D4Y metalloprotease AW20_5036 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AW20_5039 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AW20_5040 ENOG4105CIS alcohol dehydrogenase AW20_5041 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AW20_5042 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AW20_5045 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AW20_5046 ENOG4105C6Z Gluconate AW20_5047 ENOG4105CMG Carbohydrate kinase AW20_5048 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AW20_5049 ENOG4105XDF Protein of unknown function (DUF1272) AW20_5050 ENOG4105DDN Pentapeptide repeat-containing protein AW20_5053 ENOG4105C37 (CBS) domain AW20_5059 ENOG4105EV4 Multidrug resistance protein mdtH AW20_5061 ENOG4105DMQ Methyltransferase AW20_5066 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AW20_5069 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AW20_5072 ENOG4108UW5 maltose o-acetyltransferase AW20_5073 ENOG4106UW1 Major Facilitator superfamily AW20_5074 ENOG4105DKQ ROK family AW20_5075 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AW20_5087 ENOG4105CJ1 ABC, transporter AW20_5089 ENOG4108PSK reductase AW20_5093 ENOG4108RCM Nitroreductase AW20_5094 ENOG4105KVH Transcriptional regulator AW20_5097 ENOG4105CUT histidyl-tRNA synthetase AW20_5098 ENOG4108Z66 YbaK ebsC protein AW20_51 ENOG4105E1F short-chain dehydrogenase reductase AW20_5100 ENOG41067QW Transcriptional regulator AW20_5103 ENOG4108K8S endonuclease I AW20_5108 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AW20_5109 ENOG4108JJB ABC transporter AW20_511 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AW20_5115 ENOG4105DYS nad(p)h dehydrogenase (quinone) AW20_5117 ENOG4105CRW Short chain fatty acid transporter AW20_5119 ENOG4105KBX Transcriptional regulator, TetR family AW20_512 ENOG4108JUB Transcriptional regulator AW20_5120 ENOG4105KPY Small multidrug resistance protein AW20_5121 ENOG4105RXJ AW20_5123 ENOG41069JR AW20_5124 ENOG4105DA5 (ABC) transporter AW20_5128 ENOG4105CZM Major Facilitator AW20_5129 ENOG4107MII Sugar-specific transcriptional regulator TrmB AW20_513 ENOG4108TSC N-acetyltransferase AW20_5131 ENOG4108ISG Major Facilitator AW20_5139 ENOG4105HIR S-layer domain protein AW20_514 ENOG4107S4Y M20 DapE family protein YgeY AW20_5142 ENOG410874W AraC family transcriptional regulator AW20_5143 ENOG41082W1 Cupin 2, conserved barrel domain protein AW20_5146 ENOG4108AEY RNA polymerase sigma factor AW20_5150 ENOG4108JQ1 Dehydrogenase AW20_5154 ENOG4105DVH amino acid AW20_5156 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AW20_5159 ENOG4108JPW Aminotransferase AW20_5161 ENOG4105EJQ L-serine dehydratase AW20_5162 ENOG4105C44 Serine transporter AW20_5165 ENOG4108JGH Tetr family transcriptional regulator AW20_5166 ENOG4105EQ0 Major Facilitator superfamily AW20_5167 ENOG4105MZU cell filamentation protein AW20_517 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW20_5170 ENOG4107QJQ Mate efflux family protein AW20_5177 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AW20_5185 ENOG4105TRI Hydrolase AW20_5191 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AW20_5193 ENOG4106P55 Transcriptional regulator AW20_5195 ENOG4107QR9 Iron-sulfur cluster binding protein AW20_5196 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AW20_5197 ENOG4105DJB Major Facilitator Superfamily AW20_5198 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AW20_5200 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 AW20_5201 ENOG4108U05 Transcriptional regulator AW20_5204 ENOG4105BZU Histidine kinase AW20_5207 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AW20_5208 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AW20_5211 ENOG4105JQZ Methyltransferase AW20_5212 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AW20_5214 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AW20_5215 ENOG4108NNI Beta-lactamase domain-containing protein AW20_5218 ENOG4105VZ8 Transcriptional regulator AW20_522 ENOG4105C37 (CBS) domain AW20_5224 ENOG4105K6H D-cysteine desulfhydrase AW20_5229 ENOG41062D9 Histidine kinase AW20_5230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_5233 ENOG4105IIP Membrane AW20_5235 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW20_5236 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AW20_5250 ENOG4108YXU transcriptional regulator AsnC family AW20_5251 ENOG4105CHR reductase AW20_5253 ENOG4105F7F Chaperone AW20_5257 ENOG41085FC arsR family transcriptional regulator AW20_5258 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AW20_5259 ENOG4105D6J arsenicaL-resistance protein AW20_5265 ENOG4105DIK (ABC) transporter AW20_5266 ENOG4105CC5 ABC transporter AW20_5267 ENOG4105DSE periplasmic solute binding protein AW20_5268 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AW20_5269 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AW20_5271 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AW20_5272 ENOG4108TWJ NADH dehydrogenase subunit 5 AW20_5275 ENOG4105CVP deoxyribo-dipyrimidine photolyase AW20_5276 ENOG4108606 TspO/MBR family AW20_5284 ENOG41090MY MarR family Transcriptional regulator AW20_529 ENOG4105E90 ABC transporter AW20_5290 ENOG4105CHJ isochorismatase hydrolase AW20_5292 ENOG4105CH6 catalase AW20_5293 ENOG4105CGH 5'-nucleotidase AW20_53 ENOG4107RUY (E1 component), alpha subunit AW20_530 ENOG4108IJ8 ABC transporter AW20_5302 ENOG4105CSV Glutaminase AW20_5307 ENOG4108Q8B Spore germination protein AW20_5308 ENOG4108NHD germination protein AW20_5309 ENOG4108NHD germination protein AW20_5312 ENOG4105C6K Malic enzyme AW20_5314 ENOG4105II7 pyrroline-5-carboxylate reductase AW20_5316 ENOG4105CUB amino acid AW20_5317 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AW20_5319 ENOG4108IMY Transcriptional regulator AW20_5320 ENOG4105HDK L-asparaginase AW20_5321 ENOG4108IJ0 Aspartate ammonia-lyase AW20_5324 ENOG4105E2A Dehydrogenase AW20_5339 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AW20_5345 ENOG4105DWD nucleoside recognition domain protein AW20_5349 ENOG4105FDT acyl-CoA dehydrogenase AW20_5351 ENOG4108ZHR arsR family transcriptional regulator AW20_5352 ENOG4108ZRV stage ii sporulation protein p AW20_5353 ENOG4106N3A copper homeostasis protein cutc AW20_5355 ENOG4107258 Transcriptional regulator AW20_5356 ENOG4105P4J Allophanate hydrolase, subunit 1 AW20_536 ENOG4105CMG Carbohydrate kinase AW20_5364 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AW20_5366 ENOG4107RF6 penicillin-binding protein AW20_537 ENOG4105CMG Carbohydrate kinase AW20_5374 ENOG4105F1N DNA alkylation repair AW20_5376 ENOG4108IQI permease AW20_5377 ENOG4105KNA -acetyltransferase AW20_5378 ENOG410635A Membrane AW20_5394 ENOG4108XET gCN5-related N-acetyltransferase AW20_5401 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AW20_5403 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AW20_5410 ENOG4105FS7 Transcriptional regulator AW20_5411 ENOG4108TVJ Nitroreductase AW20_5413 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AW20_5422 ENOG4105C8Y Acetylornithine aminotransferase AW20_5424 ENOG4105CKK Glycosyl transferase, family 2 AW20_5429 ENOG4105CKK Glycosyl transferase, family 2 AW20_5431 ENOG4105CSH Transporter AW20_5434 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AW20_5439 ENOG41068WN AW20_5441 ENOG4108WCX response regulator AW20_5443 ENOG41090T1 Membrane AW20_5446 ENOG4105VMP Transcriptional regulator AW20_5448 ENOG4105G6Z alkaline phosphatase AW20_5449 ENOG4105ECK Fatty Acid Desaturase AW20_545 ENOG4106KNT transcriptional regulator AW20_5450 ENOG4105E0Y RtcB Protein AW20_5452 ENOG4107258 Transcriptional regulator AW20_5454 ENOG4105II7 pyrroline-5-carboxylate reductase AW20_5455 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AW20_5461 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AW20_5466 ENOG41061GT Aldolase AW20_5469 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AW20_547 ENOG4105WH1 Two component transcriptional regulator luxr family AW20_5470 ENOG4105DKT Transcriptional regulator AW20_5472 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AW20_5474 ENOG4105D4B ABC, transporter AW20_548 ENOG4105BZU Histidine kinase AW20_5480 ENOG4105EMN RNA polymerase sigma factor AW20_5482 ENOG41069ER domain protein AW20_5485 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) AW20_549 ENOG4105D8X mechanosensitive ion channel AW20_5490 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AW20_5491 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AW20_5492 ENOG4105CIH Imidazole acetol-phosphate transaminase AW20_5496 ENOG41082JN Transcriptional regulator AW20_5497 ENOG4105EYF MMPL domain protein AW20_5498 ENOG4105EYF MMPL domain protein AW20_55 ENOG4107QKR Dehydrogenase AW20_5500 ENOG4105C5H ABC transporter AW20_5501 ENOG4105E0M Sulfatase AW20_5502 ENOG4108ZCF integral membrane protein AW20_5506 ENOG4107VC0 DNA alkylation repair enzyme AW20_5516 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AW20_5520 ENOG4105E09 nadh pyrophosphatase AW20_5525 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AW20_5526 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AW20_5527 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AW20_5529 ENOG4105C02 permease AW20_5538 ENOG4105DVE abc transporter atp-binding protein AW20_5545 ENOG4105CHM Aminotransferase AW20_5552 ENOG41089UC methyltransferase, type 11 AW20_5555 ENOG4107BMA Transglycosylase associated protein AW20_5559 ENOG4106K7D Major facilitator family transporter AW20_556 ENOG4105F0I Aminotransferase AW20_5560 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AW20_5568 ENOG4105EPR degv family AW20_557 ENOG4108MES Periplasmic binding protein AW20_5571 ENOG4105DPN Oligoendopeptidase f AW20_5578 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_5579 ENOG4105BZU Histidine kinase AW20_5580 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AW20_5588 ENOG4105DTQ mandelate racemase muconate lactonizing AW20_5591 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AW20_5592 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AW20_5595 ENOG4107T5V SNARE associated Golgi AW20_5602 ENOG41080HI glycine oxidase AW20_5603 ENOG4105CTU Proline racemase AW20_5604 ENOG4105CTU Proline racemase AW20_5605 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AW20_5606 ENOG4105C26 Dehydrogenase AW20_561 ENOG4105CAQ asparagine synthetase AW20_5617 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AW20_5619 ENOG4108MEK Metal-binding protein YodA AW20_562 ENOG4107Y70 Heat shock protein AW20_5621 ENOG4105DQ6 Transposase AW20_5622 ENOG4105DQ6 Transposase AW20_5625 ENOG4105DQ6 Transposase AW20_5626 ENOG4105DQ6 Transposase AW20_5628 ENOG4108IBT Inherit from COG: transposase AW20_563 ENOG4108KF3 Electron transport protein SCO1 SenC AW20_5635 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW20_5637 ENOG4105KRN Transcriptional regulator, abrb family AW20_564 ENOG4105E8R UPF0173 metal-dependent hydrolase AW20_565 ENOG4108RCR degv family AW20_5659 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AW20_5665 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AW20_567 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AW20_5673 ENOG4105DQ6 Transposase AW20_5674 ENOG4105DQ6 Transposase AW20_5678 ENOG4105C6Y Udp-glucose 6-dehydrogenase AW20_5679 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AW20_5680 ENOG4108NV9 Glycosyl Transferase AW20_5682 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AW20_5683 ENOG4106AKK s-layer domain-containing protein AW20_5689 ENOG4105DHF Membrane AW20_569 ENOG4108UT2 hemolysin iii AW20_570 ENOG4105E9Q Acyl-transferase AW20_571 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AW20_572 ENOG4107RVG penicillin-binding protein AW20_5738 ENOG4105CNU cell division protein FtsK AW20_575 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AW20_5765 ENOG4105EKQ RNA-directed DNA polymerase AW20_5786 ENOG4105EKQ RNA-directed DNA polymerase AW20_579 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AW20_584 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AW20_586 ENOG4105KD7 acetyltransferase AW20_589 ENOG4105C0A alcohol dehydrogenase AW20_590 ENOG4105CY2 Citrate transporter AW20_591 ENOG4107XGZ Hydrolase AW20_595 ENOG4105C8J )-transporter AW20_598 ENOG41062D9 Histidine kinase AW20_599 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_60 ENOG41062ES Transcriptional regulator AW20_600 ENOG4107QPK )-transporter AW20_601 ENOG4105BZW Glycerate kinase AW20_620 ENOG4105EC2 ftsk spoIIIe AW20_624 ENOG4105C5S asparaginyl-tRNA synthetase AW20_625 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AW20_628 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AW20_634 ENOG4105C75 arginyL-tRNA synthetase AW20_635 ENOG4107YX5 Pfam:DUF548 AW20_639 ENOG41061H0 Monooxygenase AW20_64 ENOG4105E98 transcriptional regulator DeoR family AW20_642 ENOG4108UUM single-stranded DNA-binding protein AW20_645 ENOG4105C5H ABC transporter AW20_649 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW20_652 ENOG4105MCT stage V sporulation protein S AW20_659 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AW20_660 ENOG4108IFG nitrite reductase, (NAD(P)H) AW20_661 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AW20_662 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AW20_663 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AW20_664 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AW20_669 ENOG4108ZAF Molybdopterin AW20_670 ENOG4105CVM Molybdenum cofactor synthesis domain protein AW20_671 ENOG4105D06 uba thif-type nad fad binding protein AW20_672 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AW20_673 ENOG4107V6Q Cyclic nucleotide-binding domain AW20_678 ENOG4105R3A Nitrate reductase AW20_679 ENOG4108IUE nitrate reductase beta subunit AW20_68 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AW20_683 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AW20_686 ENOG4108V06 Glutathione peroxidase AW20_691 ENOG4105EMN RNA polymerase sigma factor AW20_692 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AW20_694 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase AW20_695 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AW20_699 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AW20_704 ENOG4105KBJ sporulation protein ytfj AW20_713 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AW20_719 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW20_720 ENOG4108JYZ YitT family AW20_721 ENOG41087PP glycosyltransferase MGT family AW20_725 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AW20_727 ENOG4108X4Q Hydrolase AW20_732 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AW20_734 ENOG4108VXD carboxy-peptidase AW20_736 ENOG4108ZRV stage ii sporulation protein p AW20_74 ENOG4107Z3H Transcriptional regulator, TetR family AW20_740 ENOG4108Z7R Chaperone CsaA AW20_744 ENOG4105C37 (CBS) domain AW20_745 ENOG4105SXS Protein of unknown function (DUF456) AW20_749 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW20_75 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AW20_751 ENOG4108S4H thioesterase Superfamily protein AW20_753 ENOG4108PJD permease AW20_756 ENOG4107T5V SNARE associated Golgi AW20_76 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AW20_760 ENOG4105CVJ phosphoglycerate mutase AW20_765 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AW20_767 ENOG4105K4T epimerase AW20_769 ENOG4105DSE periplasmic solute binding protein AW20_77 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AW20_781 ENOG4105CKI cobalamin synthesis protein AW20_782 ENOG4107QM2 Aldo Keto reductase AW20_786 ENOG4105DEN Luciferase family AW20_789 ENOG4108WPJ Ferritin-like domain AW20_790 ENOG4108K88 Membrane AW20_793 ENOG4105C8Q Methyl-accepting chemotaxis AW20_798 ENOG4107XZQ multidrug resistance protein AW20_799 ENOG4107SET aldo keto reductase AW20_800 ENOG4105YVS arsR family transcriptional regulator AW20_802 ENOG4105KRN Transcriptional regulator, abrb family AW20_81 ENOG4105MSI germination protein ypeb AW20_813 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AW20_815 ENOG4107RCC Major Facilitator Superfamily AW20_817 ENOG4105YWU small acid-soluble spore protein AW20_818 ENOG4108WBH protein TIM barrel AW20_821 ENOG4105CEY Amp-dependent synthetase and ligase AW20_822 ENOG4105DUU IucA IucC family protein AW20_824 ENOG4105VRR gCN5-related N-acetyltransferase AW20_825 ENOG4105KT7 mgtC SapB transporter AW20_828 ENOG4105BZU Histidine kinase AW20_829 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW20_831 ENOG4108KGH TRANSCRIPTIONal AW20_836 ENOG4105D6E homoserine dehydrogenase AW20_841 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AW20_844 ENOG4105BZU Histidine kinase AW20_845 ENOG4105EFI regulatoR AW20_846 ENOG4105BZ1 (ABC) transporter AW20_847 ENOG4105BZ1 (ABC) transporter AW20_85 ENOG4108V3A UPF0421 protein AW20_855 ENOG4108JJ8 (ABC) transporter AW20_856 ENOG4108JJ9 ABC, transporter AW20_857 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AW20_858 ENOG4105C4M (Ubiquinol oxidase) subunit I AW20_860 ENOG4105YGB Transcriptional regulator AW20_862 ENOG4105MDS 4-oxalocrotonate tautomerase AW20_864 ENOG4105SKE transcriptional Regulator LysR family AW20_866 ENOG4105C32 Amino acid ABC transporter (Permease) AW20_867 ENOG4108IV0 ABC, transporter AW20_868 ENOG4105C0Z ABC transporter AW20_870 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AW20_871 ENOG4108Z7G MaoC domain protein dehydratase AW20_875 ENOG4105CKI cobalamin synthesis protein AW20_878 ENOG4106F5Q Membrane AW20_879 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AW20_881 ENOG4108TVJ Nitroreductase AW20_882 ENOG4107ZXU DSBA oxidoreductase AW20_883 ENOG4108Z40 Transcriptional regulator AW20_884 ENOG4105GZI Transcriptional regulator AW20_885 ENOG4107RT3 EamA-like transporter family AW20_887 ENOG4105KTB nuclear export factor GLE1 AW20_888 ENOG4108T5E Copper resistance protein AW20_898 ENOG4107STQ Multicopper oxidase AW20_899 ENOG4107RAQ aminopeptidase AW20_905 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AW20_906 ENOG4105D9N nucleoside AW20_908 ENOG4107RHR regulatoR AW20_913 ENOG4105C0X amino acid AW20_914 ENOG4105C0X amino acid AW20_916 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AW20_919 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AW20_92 ENOG4105FDR Membrane AW20_924 ENOG41068WN AW20_930 ENOG4108J59 Extracellular solute-binding protein, family 5 AW20_931 ENOG4105F6J Alpha beta hydrolase fold AW20_935 ENOG4105CYC Transferase AW20_936 ENOG4105DY9 regulatoR AW20_938 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AW20_939 ENOG4105C6X Major Facilitator AW20_94 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AW20_944 ENOG4105C7B Threonine dehydratase AW20_946 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AW20_947 ENOG4108ZP8 Acetolactate synthase small subunit AW20_948 ENOG4105C7K acetolactate synthase AW20_949 ENOG4105CM2 brancheD-chain amino acid aminotransferase AW20_950 ENOG4105CHR reductase AW20_951 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AW20_955 ENOG4106KE4 Dehydrogenase AW20_958 ENOG4105H67 Protein of unknown function (DUF421) AW20_959 ENOG4105X5K response regulator receiver protein AW20_961 ENOG4105C8J )-transporter AW20_965 ENOG4105C6T cysteine synthase AW20_966 ENOG4105EU0 Major facilitator Superfamily AW20_969 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AW20_972 ENOG4105DXI Major Facilitator superfamily AW20_973 ENOG4105DXI Major Facilitator superfamily AW20_974 ENOG4105CSR polyphosphate kinase 2 AW20_982 ENOG4105FVX AW20_99 ENOG4108IUM Glycogen debranching enzyme AW20_995 ENOG4105C6K Malic enzyme AW20_996 ENOG4108IJ0 Aspartate ammonia-lyase AW20_998 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)