locus-tag class description AS53_1001 ENOG4105J76 Periplasmic binding protein AS53_1002 ENOG4105S6R Iron-hydroxamate transporter permease subunit AS53_1011 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS53_1014 ENOG4105DR4 Methyltransferase AS53_1017 ENOG4105KFN sortase, SrtB family AS53_1018 ENOG4105E0A ABC, transporter AS53_1022 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AS53_1024 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AS53_1026 ENOG4105FE9 pseudouridine synthase AS53_1029 ENOG4105DCG PHP domain protein AS53_103 ENOG4105C5F glutamine synthetase AS53_1036 ENOG4105C5S asparaginyl-tRNA synthetase AS53_1037 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AS53_1039 ENOG4108RWN rrna methyltransferase AS53_104 ENOG4105KV4 Transcriptional regulator AS53_1046 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS53_1047 ENOG4105CW7 secretion protein, HlyD family AS53_1048 ENOG4108JGH Tetr family transcriptional regulator AS53_1049 ENOG4105CN9 Peptidase m42 family protein AS53_105 ENOG4105CXI aluminum resistance protein AS53_1053 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AS53_1054 ENOG4105C22 threonyL-tRNA synthetase AS53_1055 ENOG4108TDW sporulation protein YtxC AS53_106 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AS53_1060 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AS53_1061 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AS53_1062 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AS53_1064 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AS53_1065 ENOG4105C2M dna polymerase I AS53_1066 ENOG4105BZU Histidine kinase AS53_1067 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS53_107 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AS53_1071 ENOG4108HMX isocitrate dehydrogenase (NADP) AS53_1072 ENOG4105BZN citrate synthase AS53_1074 ENOG4108REF Sporulation integral membrane protein ytvi AS53_1075 ENOG4105FS0 cytoplasmic membrane protein AS53_108 ENOG4105EN6 Membrane AS53_1080 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AS53_1081 ENOG4105C6K Malic enzyme AS53_1082 ENOG4105C0B DNA polymerase III (alpha subunit) AS53_1083 ENOG4105VV2 AS53_1085 ENOG4105SFS phosphoesterase RecJ domain protein AS53_109 ENOG4106F1P AAA ATPase, central domain protein AS53_1092 ENOG4105DC7 peptidase M24 AS53_1099 ENOG4105Z7P Acetyltransferase (GNAT) family AS53_1100 ENOG41082W1 Cupin 2, conserved barrel domain protein AS53_1102 ENOG4105VZ8 Transcriptional regulator AS53_1106 ENOG4107YZX Universal stress protein AS53_1115 ENOG4108JYZ YitT family AS53_1119 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AS53_1121 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AS53_1122 ENOG4105KBJ sporulation protein ytfj AS53_1125 ENOG4105EFZ amidohydrolase AS53_1127 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AS53_1132 ENOG4106KR7 LysR family Transcriptional regulator AS53_1134 ENOG4105U5Y Transcriptional regulator AS53_1135 ENOG4105U5Y Transcriptional regulator AS53_1137 ENOG4105C28 cystathionine AS53_1141 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AS53_1143 ENOG4105EMN RNA polymerase sigma factor AS53_1146 ENOG4105F1V Acetoin utilization protein AS53_1147 ENOG4105W87 Cbs domain AS53_1148 ENOG4105DGU Histone deacetylase AS53_1150 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS53_1152 ENOG4107SNB ankyrin repeat protein YahD AS53_1153 ENOG4105EP9 oxidoreductase AS53_1159 ENOG4105ETE Transcriptional regulator (LacI family AS53_116 ENOG41069ER domain protein AS53_1163 ENOG4105C88 aminopeptidase AS53_117 ENOG4105DM4 PTS System AS53_1172 ENOG4108VDD TRNA binding domain protein AS53_1178 ENOG4105C8F Beta-lactamase domain protein AS53_118 ENOG4105DE4 1-phosphofructokinase AS53_1181 ENOG4108V15 phosphotransferase enzyme family AS53_1182 ENOG4108IUM Glycogen debranching enzyme AS53_1184 ENOG4107QSE Dipeptidase AS53_1185 ENOG4107QSE Dipeptidase AS53_1186 ENOG4105YW5 deoR family transcriptional regulator AS53_1189 ENOG4105CBX hi0933 family AS53_119 ENOG4105E98 transcriptional regulator DeoR family AS53_1196 ENOG4108VJ1 Transcriptional regulator (CarD family AS53_1197 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AS53_1198 ENOG4105CSC Glucose uptake protein AS53_12 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AS53_120 ENOG4107QW4 alcohol dehydrogenase AS53_1201 ENOG4108ZAF Molybdopterin AS53_1202 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AS53_1203 ENOG4105CVM Molybdenum cofactor synthesis domain protein AS53_1205 ENOG4105D06 uba thif-type nad fad binding protein AS53_1206 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AS53_121 ENOG4107QW4 alcohol dehydrogenase AS53_1210 ENOG41085GJ domain protein AS53_1212 ENOG4105DWV Homoserine O-trans-acetylase AS53_1214 ENOG4108B31 Spore germination protein AS53_122 ENOG4108SJC Membrane AS53_1220 ENOG410605W Major Facilitator AS53_1221 ENOG4107S91 Sodium hydrogen exchanger AS53_1222 ENOG4105NCW Trka-c domain protein AS53_1225 ENOG4105C19 ABC transporter AS53_1229 ENOG4105N5T Radical SAM Protein AS53_1231 ENOG4105DA5 (ABC) transporter AS53_1237 ENOG4105E8V Alpha Beta Hydrolase Fold protein AS53_1238 ENOG4108Z0R Transferase AS53_1239 ENOG4105YVM Phosphoesterase, PA-phosphatase related AS53_1240 ENOG4105BZF Glycosyl transferase (Group 1 AS53_1242 ENOG4108RIR Molybdenum cofactor biosynthesis protein AS53_125 ENOG4105C85 amino acid AS53_1252 ENOG4105EGD dinuclear metal center protein, YbgI family AS53_1253 ENOG4105BZU Histidine kinase AS53_1254 ENOG4105BZU Histidine kinase AS53_1255 ENOG4107S9D Alpha beta hydrolase AS53_1256 ENOG4107T7U Sulfatase AS53_1260 ENOG4105D2X ABC transporter substrate-binding protein AS53_1262 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AS53_1266 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AS53_1273 ENOG4108V2W Carbonate dehydratase AS53_1275 ENOG4105C4M (Ubiquinol oxidase) subunit I AS53_1276 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AS53_1285 ENOG41087YS Phage shock protein A AS53_129 ENOG4105TMB Formate nitrite transporter AS53_1292 ENOG4105BZU Histidine kinase AS53_1293 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_1298 ENOG4108UGV hypoxanthine phosphoribosyltransferase AS53_1299 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AS53_130 ENOG4105K70 DNA-binding protein AS53_1306 ENOG4107ZTW SNARE associated Golgi AS53_1309 ENOG4105C19 ABC transporter AS53_131 ENOG4105C59 p-type ATPase AS53_1310 ENOG41086D8 Transcriptional regulator AS53_132 ENOG410681U heavy metal transport detoxification protein AS53_1321 ENOG4105C6Z Gluconate AS53_1322 ENOG4105FDP GntR family transcriptional regulator AS53_1326 ENOG41069H0 dihydroorotase EC 3.5.2.3 AS53_133 ENOG4105VPX protein, conserved in bacteria AS53_1332 ENOG4105DTQ mandelate racemase muconate lactonizing AS53_1334 ENOG4108IPT Naphthoate synthase AS53_1335 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AS53_1336 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AS53_1337 ENOG4105E4F Isochorismate synthase AS53_1338 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AS53_1340 ENOG4105VEQ Cold shock protein AS53_1345 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AS53_1347 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AS53_1349 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AS53_135 ENOG4105NIV Esterase AS53_136 ENOG4105E0A ABC, transporter AS53_1368 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AS53_1384 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AS53_1392 ENOG4105KT7 mgtC SapB transporter AS53_1394 ENOG4107PBV potassium channel AS53_1395 ENOG4107QYV phosphohexose isomerase AS53_1396 ENOG4105WG9 Conserved Protein AS53_1398 ENOG4105CHM Aminotransferase AS53_1399 ENOG4108ZB6 transcriptional regulator AsnC family AS53_1400 ENOG4105C5I Dehydrogenase AS53_1401 ENOG4108MUZ hydrolase AS53_1403 ENOG4105C87 Aminotransferase class I and II AS53_1406 ENOG4105Y38 Kinase-associated protein B AS53_1408 ENOG4107R3E Citrate transporter AS53_141 ENOG4105CGK Exodeoxyribonuclease III AS53_1411 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AS53_1412 ENOG4105KA0 thioesterase Superfamily protein AS53_1416 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AS53_1420 ENOG41069ER domain protein AS53_1423 ENOG4105CEP NADH dehydrogenase AS53_1429 ENOG4105EWC Purine nucleoside phosphorylase AS53_143 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AS53_1432 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AS53_1436 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AS53_1437 ENOG4105C4B ABC transporter, permease AS53_1438 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AS53_144 ENOG4105D03 DNA-3-methyladenine glycosylase II AS53_1447 ENOG41083MR nifu domain-containing protein AS53_1450 ENOG4108W5N phosphatidylglycerophosphatase a AS53_1452 ENOG4105DYS nad(p)h dehydrogenase (quinone) AS53_1453 ENOG4105D4U had-superfamily hydrolase, subfamily iia AS53_1456 ENOG4105CBT Fructose-1,6-bisphosphatase AS53_1459 ENOG4105MMD transcriptional regulator AS53_1460 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AS53_1461 ENOG4107TXC Transcriptional regulator AS53_1462 ENOG41090T1 Membrane AS53_1467 ENOG4105FAA peptidase M23 AS53_1469 ENOG4105KZD Domain of unknown function (DUF1805) AS53_1470 ENOG4107R8B 5'-nucleotidase AS53_1473 ENOG4105DIW FeS assembly protein SUFB AS53_1474 ENOG4108UNV SUF system FeS assembly protein, NifU family AS53_1475 ENOG4105C9B Cysteine desulfurase AS53_1476 ENOG4105JRK feS assembly protein SufD AS53_1477 ENOG4105C3K feS assembly ATPase SufC AS53_1478 ENOG4105D01 (LipO)protein AS53_1479 ENOG4105D01 (LipO)protein AS53_1480 ENOG4108UMI ABC transporter, permease AS53_1486 ENOG41080E8 Transcriptional regulator, Spx MgsR family AS53_1495 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AS53_15 ENOG4105BZ1 (ABC) transporter AS53_150 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AS53_1501 ENOG4108W8B Beta-lactamase domain protein AS53_1502 ENOG4105C1G acyl-Coa dehydrogenase AS53_1503 ENOG4105CHU acetyl-coa acetyltransferase AS53_1506 ENOG4105DZ1 carboxypeptidase AS53_151 ENOG4105BZU Histidine kinase AS53_1510 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AS53_1514 ENOG4108SUT Major Facilitator Superfamily AS53_1515 ENOG4107R7I amino acid AS53_1517 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AS53_1519 ENOG4107AYK membrAne AS53_1526 ENOG4107ZTW SNARE associated Golgi AS53_1528 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AS53_1529 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_1530 ENOG4105BZU Histidine kinase AS53_1533 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AS53_1536 ENOG4105VG1 fes assembly suf system protein AS53_1537 ENOG4105D4Y metalloprotease AS53_154 ENOG41067MG lrgb family AS53_1541 ENOG4107S91 Sodium hydrogen exchanger AS53_1542 ENOG4105NCW Trka-c domain protein AS53_1544 ENOG4108RMU ferritin dps family protein AS53_1547 ENOG4108URH decarboxylase AS53_1552 ENOG4105D9N nucleoside AS53_1553 ENOG4105D9N nucleoside AS53_1556 ENOG4108RYK Nad-dependent epimerase dehydratase AS53_1561 ENOG4105CV8 reductase AS53_1562 ENOG4105F27 Major Facilitator AS53_1563 ENOG4105KVH Transcriptional regulator AS53_1566 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AS53_1567 ENOG4105D4A Cell wall formation (By similarity) AS53_1569 ENOG4105C8Q Methyl-accepting chemotaxis AS53_157 ENOG4107TTQ Alpha beta hydrolase fold AS53_1571 ENOG4105WMR Protein CrcB homolog AS53_1572 ENOG4105WMR Protein CrcB homolog AS53_1575 ENOG4108MK9 spermidine N(1)-acetyltransferase AS53_1576 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AS53_1579 ENOG4108IPW abc transporter atp-binding protein AS53_158 ENOG4107YEI lmbE family AS53_1580 ENOG4105CM4 permease protein AS53_1585 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AS53_1587 ENOG4105XZU Preprotein translocase, subunit SecG AS53_1588 ENOG41067MG lrgb family AS53_16 ENOG4105BZ1 (ABC) transporter AS53_1608 ENOG4105EFC phage portal protein HK97 family AS53_1613 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AS53_1615 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AS53_1616 ENOG4105CP7 Triose-phosphate isomerase AS53_162 ENOG4105F0V Cell wall hydrolase AS53_1621 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_1625 ENOG41090VF Stage v sporulation protein ac AS53_1626 ENOG4105CZ3 stage V sporulation protein ad AS53_1629 ENOG4105H67 Protein of unknown function (DUF421) AS53_163 ENOG4107R6R udp-galactopyranose mutase AS53_1630 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AS53_1631 ENOG4105KRI phosphocarrier protein (HPr AS53_1633 ENOG4105CHW UPF0052 protein AS53_1635 ENOG4108Z4K mutator MutT protein AS53_1637 ENOG4105C3M thioredoxin reductase AS53_1639 ENOG4108S4C acetyltransferase AS53_164 ENOG4105E0M Sulfatase AS53_1643 ENOG41086DT Membrane protein of unknown function AS53_1645 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AS53_1646 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AS53_1647 ENOG4105D7V transposase AS53_1650 ENOG4107TXC Transcriptional regulator AS53_1654 ENOG4105HMI Membrane AS53_1655 ENOG4105DUM transcriptional regulator, lysR family AS53_1657 ENOG4108WS4 fmn reductase AS53_1660 ENOG4105BZ1 (ABC) transporter AS53_1662 ENOG4105CN1 protease AS53_1663 ENOG4105CRP Part of the ABC transporter FtsEX involved in AS53_1664 ENOG4105CAK Cell division ATP-binding protein ftsE AS53_1666 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AS53_1667 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AS53_1668 ENOG4105MS2 ribosomal subunit Interface protein AS53_1669 ENOG4105VEQ Cold shock protein AS53_1670 ENOG41081UC Inherit from COG: Competence protein AS53_1673 ENOG4105KVH Transcriptional regulator AS53_1675 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AS53_1676 ENOG4108KGH TRANSCRIPTIONal AS53_1677 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AS53_1678 ENOG4105C6Y Udp-glucose 6-dehydrogenase AS53_1679 ENOG4105ESV Glycosyl transferase, family 4 AS53_168 ENOG4107QHE Choloylglycine hydrolase AS53_1681 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AS53_1684 ENOG410901P UPF0249 protein AS53_1685 ENOG4105F8D glycoside hydrolase family 4 AS53_1686 ENOG4105VCP PTS System AS53_1687 ENOG4105CK1 PTS System AS53_1689 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AS53_1690 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AS53_1691 ENOG4105VCP PTS System AS53_1693 ENOG4105VZJ PTS System AS53_1696 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AS53_1697 ENOG4105ECB domain protein AS53_1698 ENOG4107RSM transcriptional regulator AS53_1706 ENOG4105DAA L-lactate AS53_1708 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AS53_1710 ENOG4105E0M Sulfatase AS53_1716 ENOG4107R8N Glycosyl transferase, family 2 AS53_1718 ENOG4105C94 Transporter AS53_1719 ENOG41069ER domain protein AS53_1724 ENOG4105KBK Zinc finger, swim domain protein AS53_1725 ENOG4105C0D helicase AS53_173 ENOG4105DA5 (ABC) transporter AS53_1731 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_1733 ENOG4107RBB ABC transporter, permease AS53_1734 ENOG4105C19 ABC transporter AS53_1738 ENOG4105CXY transporter AS53_1741 ENOG4105BZU Histidine kinase AS53_1742 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_1743 ENOG4105CMR udp-glucose 4-epimerase AS53_1746 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AS53_1758 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AS53_1760 ENOG4105FRN stage II sporulation protein AS53_1763 ENOG4105DY9 regulatoR AS53_1764 ENOG4108IUW ABC transporter AS53_1768 ENOG4106778 Protein of unknown function (DUF1146) AS53_1769 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AS53_1770 ENOG4105C8S subunit m AS53_1771 ENOG4105D65 subunit l AS53_1776 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AS53_1777 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AS53_1779 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AS53_178 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AS53_1780 ENOG4105BZU Histidine kinase AS53_179 ENOG4105DQU oxidoreductase, subunit beta AS53_1790 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AS53_1791 ENOG41062M3 atp synthase AS53_1796 ENOG4108YZG isomerase AS53_1799 ENOG4108VGI doxx family AS53_180 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AS53_1800 ENOG4107XC4 flavin reductase domain protein, FMN-binding AS53_1803 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AS53_1805 ENOG4108ZXQ stage ii sporulation protein r AS53_1806 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AS53_1807 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AS53_181 ENOG4108IGT Dipeptidase AS53_1810 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AS53_1811 ENOG4105CBT Fructose-1,6-bisphosphatase AS53_1812 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AS53_1819 ENOG4105C1G acyl-Coa dehydrogenase AS53_182 ENOG4105MCT stage V sporulation protein S AS53_1820 ENOG4105C1G acyl-Coa dehydrogenase AS53_1821 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AS53_1823 ENOG4105DF6 Fe-S oxidoreductase AS53_1826 ENOG4105BZU Histidine kinase AS53_183 ENOG4105D48 metallophosphoesterase AS53_1831 ENOG4105BZU Histidine kinase AS53_1832 ENOG4105KCT ABC transporter AS53_1833 ENOG4108M15 ABC transporter AS53_1834 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AS53_1838 ENOG4105IIU Aminopeptidase AS53_1842 ENOG4105EMN RNA polymerase sigma factor AS53_1844 ENOG410684U Domain of unknown function (DUF1934) AS53_1848 ENOG4105CYW agmatinase AS53_1850 ENOG4105DXB Major Facilitator superfamily AS53_1851 ENOG4107SWG transcriptional regulator MERR family AS53_1852 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AS53_1853 ENOG4105BZ4 penicillin-binding protein AS53_1854 ENOG4108XFG YwhD family AS53_1855 ENOG4108Z4T Peptidase M50 AS53_1856 ENOG41069HH 4-oxalocrotonate tautomerase AS53_1857 ENOG4105DCI Phosphohydrolase AS53_1858 ENOG4108MES Periplasmic binding protein AS53_1859 ENOG4105E0A ABC, transporter AS53_1860 ENOG4105EHG Permease protein AS53_1861 ENOG4105DQ5 transport system permease protein AS53_1862 ENOG4105DQ5 transport system permease protein AS53_1864 ENOG4108VCI transcription factor, rsfa family AS53_1867 ENOG4108IJ2 phosphate acetyltransferase AS53_1870 ENOG4108VKI Cell wall hydrolase AS53_1874 ENOG4107SVH Potassium channel protein AS53_1876 ENOG410667J hydrolase AS53_1877 ENOG4105VCH membrane AS53_1879 ENOG4108TU7 Inherit from COG: (ABC) transporter AS53_188 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AS53_1880 ENOG4105CJ1 ABC, transporter AS53_1881 ENOG41090WU lipolytic protein G-D-S-L family AS53_1884 ENOG4105D6E homoserine dehydrogenase AS53_1889 ENOG4108Y4K DNA-binding transcriptional activator AS53_1891 ENOG4105WH1 Two component transcriptional regulator luxr family AS53_1892 ENOG4105BZU Histidine kinase AS53_1893 ENOG4105BZU Histidine kinase AS53_1894 ENOG4105DWF phosphomethylpyrimidine kinase AS53_1895 ENOG4105BZU Histidine kinase AS53_1896 ENOG4105VCD cytoplasmic protein AS53_1897 ENOG4105D22 carbon starvation protein AS53_1898 ENOG4105DY9 regulatoR AS53_1899 ENOG41079KZ Major Facilitator Superfamily AS53_1903 ENOG4105EN6 Membrane AS53_1904 ENOG4106YBV Methyl-accepting chemotaxis AS53_1907 ENOG4108S4H thioesterase Superfamily protein AS53_1909 ENOG4105JEU Glycosyl transferase, family 2 AS53_191 ENOG4105XZV Protein of unknown function (DUF3243) AS53_1910 ENOG4105C5H ABC transporter AS53_1915 ENOG4105CKK Glycosyl transferase, family 2 AS53_1916 ENOG41067SE Tetr family transcriptional regulator AS53_1918 ENOG4105E0X reductase AS53_1919 ENOG4106F5Q Membrane AS53_192 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AS53_1922 ENOG4105DY9 regulatoR AS53_1923 ENOG4108HRK Histidine kinase AS53_1924 ENOG4107RGD Major Facilitator superfamily AS53_1927 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AS53_1929 ENOG4105IW1 AmiS UreI transporter AS53_1931 ENOG4105CMR udp-glucose 4-epimerase AS53_1932 ENOG4108UT2 hemolysin iii AS53_1934 ENOG4105C1J atp-dependent rna helicase AS53_1942 ENOG4105C0H protease AS53_1943 ENOG4105Q2H domain protein AS53_1946 ENOG4105BZU Histidine kinase AS53_1947 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_1953 ENOG4105CDU Replicative dna helicase AS53_1955 ENOG4105BZR domain protein AS53_1956 ENOG4108XMW Membrane AS53_1958 ENOG4108UUM single-stranded DNA-binding protein AS53_196 ENOG4105UIB (ABC) transporter AS53_1960 ENOG4105C3G gtp-binding protein AS53_1961 ENOG4105VDK protein, conserved in bacteria AS53_1962 ENOG4105D8X mechanosensitive ion channel AS53_1963 ENOG4108ZDA Sporulation protein YyaC AS53_1964 ENOG4105FA0 parb-like partition protein AS53_1965 ENOG4107QJE Chromosome Partitioning Protein AS53_1969 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AS53_197 ENOG4105UIB (ABC) transporter AS53_1971 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AS53_1975 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AS53_1976 ENOG410848D S4 domain protein YaaA AS53_1979 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AS53_198 ENOG4108JQ9 ABC transporter AS53_1985 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AS53_199 ENOG4105DIH basic membrane AS53_1992 ENOG4105ZMH deoxynucleoside kinase AS53_1994 ENOG4105GTG Isochorismatase AS53_1995 ENOG4108Z6B deaminase AS53_1996 ENOG4105C6E dna polymerase iii AS53_20 ENOG4105D7V transposase AS53_200 ENOG4105FDP GntR family transcriptional regulator AS53_2000 ENOG41067KS pro-sigma K processing AS53_2008 ENOG4105CXN decarboxylase AS53_201 ENOG4107QZI cell division protein FtsK AS53_2010 ENOG4105FA2 dna polymerase iii AS53_2011 ENOG4105MA4 psp1 domain protein AS53_2013 ENOG41060K3 Methyltransferase AS53_2014 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AS53_2015 ENOG4105KRN Transcriptional regulator, abrb family AS53_2018 ENOG4105F8V Hydrolase, tatD family AS53_2019 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AS53_2021 ENOG4105XFA sporulation peptidase YabG AS53_2022 ENOG4105W42 Veg protein AS53_2025 ENOG4105DFT pur operon repressor AS53_2026 ENOG4105KME endoribonuclease L-psp AS53_2029 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AS53_203 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AS53_2030 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AS53_2032 ENOG4108JA2 transcriptioN-repair coupling factor AS53_2033 ENOG4108M14 stage v sporulation protein t AS53_2035 ENOG4108IY2 MazG family AS53_2036 ENOG41082I2 s4 domain protein AS53_2037 ENOG4105VYY sporulation protein yabp AS53_2040 ENOG41060GV RNA binding s1 domain protein AS53_2044 ENOG4105G3A stage ii sporulation protein e AS53_2045 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AS53_2046 ENOG4108UGV hypoxanthine phosphoribosyltransferase AS53_2047 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AS53_205 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AS53_2050 ENOG4105C6T cysteine synthase AS53_2051 ENOG4105CRQ synthase (Component I) AS53_2052 ENOG4105DDQ anthranilate synthase AS53_2053 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AS53_2054 ENOG4105EEI dihydropteroate synthase AS53_2055 ENOG4105KRF dihydroneopterin aldolase AS53_2056 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AS53_2058 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AS53_2064 ENOG4108Z0C Uvrb UvrC protein AS53_2067 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AS53_2069 ENOG4105CTP PilT protein domain protein AS53_207 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AS53_2073 ENOG4105D7W serine acetyltransferase AS53_2076 ENOG4105C2N RNA methyltransferase TrmH family group 3 AS53_2077 ENOG4105M0M Tetracycline resistance protein AS53_2078 ENOG4105QIV RNA polymerase AS53_208 ENOG4108S0H Dipicolinic acid synthetase, b subunit AS53_2080 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AS53_2085 ENOG4107Y49 methyltransferase AS53_2087 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AS53_2088 ENOG4105XPM ribosomal protein AS53_209 ENOG4105E35 Dipicolinate synthase subunit A AS53_211 ENOG4105C1V Peptidase, M16 AS53_2110 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AS53_2115 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AS53_2117 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AS53_2119 ENOG41067V7 50S ribosomal protein L36 AS53_2125 ENOG4108JJB ABC transporter AS53_2126 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AS53_2127 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AS53_2132 ENOG4105D1F ATP-binding protein AS53_2135 ENOG4108NMV polysaccharide deacetylase AS53_215 ENOG4105DTN riboflavin biosynthesis protein ribF AS53_2153 ENOG4105C8B TIGR00159 family AS53_2154 ENOG4107U5W ybbr family AS53_2156 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AS53_2157 ENOG4108VQT Alpha beta hydrolase fold protein AS53_2159 ENOG4105CMG Carbohydrate kinase AS53_216 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AS53_2160 ENOG4105CMG Carbohydrate kinase AS53_2162 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AS53_2163 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AS53_2171 ENOG4108PSK reductase AS53_2172 ENOG4108UMI ABC transporter, permease AS53_2173 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AS53_2174 ENOG4105D01 (LipO)protein AS53_2175 ENOG4105EE1 crotonyl-CoA reductase AS53_2177 ENOG4105IQ5 FAD linked oxidase domain protein AS53_218 ENOG4105W7A Protein of unknown function (DUF503) AS53_2180 ENOG4105C2C drug resistance transporter, Bcr CflA AS53_2183 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AS53_2184 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS53_2185 ENOG4105C3U ABC transporter AS53_2186 ENOG4108JQ7 (ABC) transporter AS53_2192 ENOG4108J59 Extracellular solute-binding protein, family 5 AS53_2193 ENOG4108J59 Extracellular solute-binding protein, family 5 AS53_2195 ENOG4105II7 pyrroline-5-carboxylate reductase AS53_2196 ENOG4107XDY Nicotinamide Mononucleotide Transporter AS53_2198 ENOG4105E0C molybdate abc transporter AS53_2199 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AS53_220 ENOG4105VHM ribosomal protein AS53_2200 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AS53_2201 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AS53_2204 ENOG4105EGI Transcriptional regulator AS53_2208 ENOG4105F6E Acyl-transferase AS53_221 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AS53_2212 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AS53_2215 ENOG4108RE7 deoxyribonuclease AS53_2216 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AS53_222 ENOG4105CHV Transcription elongation factor NusA AS53_2220 ENOG4105C5H ABC transporter AS53_2223 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AS53_2225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS53_2226 ENOG4105C3U ABC transporter AS53_2227 ENOG4108JQ7 (ABC) transporter AS53_2228 ENOG410667J hydrolase AS53_2234 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AS53_2235 ENOG4105ERH Fumarylacetoacetate hydrolase AS53_2237 ENOG4108SC4 )-transporter AS53_2238 ENOG4105CPF Cell wall formation (By similarity) AS53_2239 ENOG4105CPF Cell wall formation (By similarity) AS53_224 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AS53_2240 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AS53_2242 ENOG4107ZXI Rhomboid family AS53_2245 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AS53_2246 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AS53_2248 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AS53_226 ENOG4105DZP Membrane-associated zinc metalloprotease AS53_2268 ENOG4105K8N protein family UPF0079, ATPase AS53_2269 ENOG41072GX Peptidase M22 Glycoprotease AS53_227 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AS53_2270 ENOG410801F ribosomal-protein-alanine acetyltransferase AS53_2271 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AS53_2272 ENOG4105C5H ABC transporter AS53_2275 ENOG4108TYN CAAX amino terminal protease family protein AS53_2279 ENOG4105C7N Xanthine uracil vitamin C permease AS53_228 ENOG4105KNE Phosphatidate cytidylyltransferase AS53_2281 ENOG4105BZU Histidine kinase AS53_2289 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AS53_229 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AS53_2295 ENOG4108SHN Glycosyl transferase, family 2 AS53_23 ENOG4105D5T phosphonate abc transporter AS53_2300 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AS53_2304 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS53_2309 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AS53_2310 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AS53_2311 ENOG4105C83 adenylosuccinate lyase AS53_2313 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AS53_2318 ENOG4108V3E phosphoribosylglycinamide formyltransferase AS53_2320 ENOG4105C12 Phosphoribosylglycinamide synthetase AS53_2325 ENOG4105C4R Atp-dependent dna helicase AS53_2331 ENOG4108W2Y isochorismatase AS53_2332 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AS53_2333 ENOG4108UMI ABC transporter, permease AS53_2334 ENOG4105D01 (LipO)protein AS53_2338 ENOG4105D0U Arsenite-activated ATPase (ArsA) AS53_2339 ENOG410834F Transcriptional regulator AS53_2344 ENOG4105CBD Diacylglycerol kinase AS53_2345 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AS53_2346 ENOG4108JPW Aminotransferase AS53_2348 ENOG4105C26 Dehydrogenase AS53_2349 ENOG4105KPY Small multidrug resistance protein AS53_2353 ENOG4105D9N nucleoside AS53_2354 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AS53_2357 ENOG4108W15 Protein of unknown function (DUF1456) AS53_2360 ENOG4105DTQ mandelate racemase muconate lactonizing AS53_2361 ENOG4105DFD Na H antiporter AS53_2366 ENOG4105D3R alkyl hydroperoxide reductase AS53_2367 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AS53_2369 ENOG4107W7X Aldolase AS53_237 ENOG4108HE4 integrase family AS53_2370 ENOG4105EHG Permease protein AS53_2371 ENOG4105DQ5 transport system permease protein AS53_2372 ENOG4108V5C ABC transporter AS53_2376 ENOG4106UIA AS53_2377 ENOG4106UIA AS53_2381 ENOG4105BZU Histidine kinase AS53_2385 ENOG410756H nucleotidyltransferase AS53_2386 ENOG4105D2S major facilitator superfamily AS53_2389 ENOG4105E5Q amino acid AbC transporter AS53_239 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AS53_2390 ENOG4105EAB amino acid AbC transporter AS53_2392 ENOG4105C8Q Methyl-accepting chemotaxis AS53_2393 ENOG4105C8Q Methyl-accepting chemotaxis AS53_2395 ENOG4105CI1 PTS System AS53_2401 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AS53_2404 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AS53_2407 ENOG4105C5H ABC transporter AS53_241 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AS53_2412 ENOG41062JF Transcriptional regulator AS53_2416 ENOG4105DEU major facilitator superfamily AS53_2419 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) AS53_2422 ENOG4108N0M stress protein AS53_2423 ENOG4106FN3 tellurium resistance protein AS53_2424 ENOG4106FN3 tellurium resistance protein AS53_2425 ENOG4107TS3 membrane protein, TerC AS53_2426 ENOG4108TTB tellurium resistance protein AS53_2430 ENOG4105KJF protein tyrosine phosphatase AS53_2432 ENOG4107U9T Pfam:Ribonuclease_BN AS53_2433 ENOG4105C59 p-type ATPase AS53_2434 ENOG4108IPJ Membrane AS53_2436 ENOG4105C3F Signal peptidase i AS53_2439 ENOG4107ZTW SNARE associated Golgi AS53_244 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AS53_2442 ENOG410606W general stress protein AS53_2443 ENOG4105UPD Calcium Proton AS53_2451 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AS53_2452 ENOG4105VTR Integrase AS53_249 ENOG4105VB6 UPF0109 protein AS53_2510 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AS53_2512 ENOG4108JUB Transcriptional regulator AS53_2514 ENOG4108IQI permease AS53_2520 ENOG4105CSV Glutaminase AS53_2522 ENOG4108A04 Beta-lactamase AS53_2525 ENOG4105CKK Glycosyl transferase, family 2 AS53_2527 ENOG4107QQG Dehydrogenase AS53_2528 ENOG4105C3I Nad-dependent epimerase dehydratase AS53_253 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AS53_2531 ENOG4105F1A Pyruvate formate-lyase AS53_2535 ENOG4105CI2 imidazolone-5-propionate hydrolase AS53_2536 ENOG4105ECP epimerase AS53_254 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AS53_2542 ENOG41067AE Membrane-bound metal-dependent hydrolase AS53_2543 ENOG4105CEN a g-specific adenine glycosylase AS53_2544 ENOG4106BXE AS53_2548 ENOG4105BZ1 (ABC) transporter AS53_2549 ENOG4107NBY Membrane AS53_2550 ENOG4105CBC glutamate synthase AS53_2552 ENOG4108IUW ABC transporter AS53_2556 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AS53_2557 ENOG4105G5W regulator Fur family AS53_257 ENOG4105CHR reductase AS53_2575 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AS53_258 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AS53_2582 ENOG4108JQC penicillin-binding protein 1A AS53_2583 ENOG4107ZQN disulfide bond AS53_2585 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AS53_2587 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AS53_2588 ENOG4105BZU Histidine kinase AS53_2590 ENOG4105CYN Serine protein kinase AS53_2594 ENOG4105C94 Transporter AS53_2597 ENOG4105DZ6 Band 7 protein AS53_2599 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AS53_26 ENOG4105CGH 5'-nucleotidase AS53_2600 ENOG4108MRH transcriptional regulatory protein AS53_2601 ENOG4105D4T Citrate transporter AS53_2605 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AS53_2606 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AS53_2607 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AS53_2608 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AS53_2609 ENOG4105BZ7 extracellular solute-binding protein family 1 AS53_261 ENOG4105CB5 ATP-dependent DNA helicase recG AS53_2610 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AS53_2611 ENOG4108STX response regulator AS53_2612 ENOG4105US7 Histidine kinase AS53_2619 ENOG4108MRH transcriptional regulatory protein AS53_262 ENOG4105DP4 dak2 domain fusion protein ylov AS53_2621 ENOG4105C6K Malic enzyme AS53_2623 ENOG4108UZ3 Transporter AS53_2624 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AS53_2628 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_263 ENOG4108ZAA Alkaline-shock protein AS53_2630 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AS53_2631 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AS53_2632 ENOG4108JB9 formate dehydrogenase AS53_2637 ENOG4105CUB amino acid AS53_2641 ENOG4105DAP Nicotinate phosphoribosyltransferase AS53_2648 ENOG41073R8 VanW family AS53_2649 ENOG4108KGH TRANSCRIPTIONal AS53_265 ENOG4105FJ0 thiamine AS53_2650 ENOG4105D9N nucleoside AS53_2651 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AS53_2652 ENOG4105C37 (CBS) domain AS53_2653 ENOG4108IJ0 Aspartate ammonia-lyase AS53_2654 ENOG4105DAA L-lactate AS53_2657 ENOG4105DUX Transporter AS53_2658 ENOG4108MES Periplasmic binding protein AS53_2659 ENOG4105DQ5 transport system permease protein AS53_266 ENOG4105DJV ribulose-phosphate 3-epimerase AS53_2660 ENOG4108IHU transport system permease protein AS53_2661 ENOG4105E0A ABC, transporter AS53_2662 ENOG4105DMQ Methyltransferase AS53_2664 ENOG4105EXW epimerase dehydratase AS53_2666 ENOG4107T89 von Willebrand factor, type A AS53_2667 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AS53_2668 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AS53_267 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AS53_2671 ENOG4105BZU Histidine kinase AS53_2672 ENOG4105D5Q Arginine ornithine antiporter AS53_2673 ENOG4107414 GntR family transcriptional regulator AS53_2674 ENOG4105C5Y PTS System AS53_2675 ENOG4105CG3 alpha amylase, catalytic region AS53_2678 ENOG4105E1K spore germination protein AS53_268 ENOG4105D9P serine threonine protein kinase AS53_2680 ENOG4105CRN Aminoglycoside phosphotransferase AS53_2681 ENOG4105BZG amino acid carrier protein AS53_2682 ENOG4105CDA abc transporter atp-binding protein AS53_2683 ENOG4105CT1 (ABC) transporter AS53_2684 ENOG4105EAD ABC transporter AS53_2685 ENOG4105DRP amino acid AbC transporter AS53_2686 ENOG4108IQI permease AS53_269 ENOG4108ZF3 Phosphatase AS53_2691 ENOG4105D29 Helix-turn-helix type 11 domain protein AS53_2692 ENOG4105NAE bifunctional deaminase-reductase domain protein AS53_2693 ENOG4105BZU Histidine kinase AS53_2696 ENOG4105CHH sulfate transporter AS53_2697 ENOG41068KF Universal stress protein AS53_2699 ENOG4105DEF Extracellular solute-binding protein, family 5 AS53_2701 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AS53_2702 ENOG4108JQ7 (ABC) transporter AS53_2704 ENOG4105CXY transporter AS53_2705 ENOG41067TZ transcriptional regulator, MarR family AS53_2706 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS53_2707 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS53_2708 ENOG4105ETE Transcriptional regulator (LacI family AS53_2709 ENOG4108RVA ribokinase AS53_271 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AS53_2711 ENOG4105C2J ABC transporter AS53_2712 ENOG4105CNN ABC, transporter AS53_2713 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AS53_2714 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AS53_2726 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AS53_2727 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AS53_2728 ENOG41069ER domain protein AS53_2729 ENOG4105VZ8 Transcriptional regulator AS53_273 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AS53_2730 ENOG4107D63 AS53_2732 ENOG4105DUX Transporter AS53_2736 ENOG4105C85 amino acid AS53_2737 ENOG4105C7N Xanthine uracil vitamin C permease AS53_274 ENOG4105C25 Primosomal protein n' AS53_2745 ENOG4105BZ9 Cytochrome C oxidase, subunit I AS53_2746 ENOG4105E2S oxidase) subunit II AS53_2749 ENOG4106CAD Protein of unknown function (DUF3311) AS53_275 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AS53_2750 ENOG4105E1V na solute symporter AS53_2753 ENOG4108NHD germination protein AS53_2754 ENOG4105CE1 Ferrous iron transport protein b AS53_2755 ENOG4105CE1 Ferrous iron transport protein b AS53_2756 ENOG4105CE1 Ferrous iron transport protein b AS53_2757 ENOG4105CVA phosphate AS53_2758 ENOG4105C8U phosphate abc transporter AS53_2759 ENOG4105E2Z phosphate ABC transporter (Permease AS53_2775 ENOG41080XQ Signal transduction protein with cbs domains AS53_2779 ENOG4105ETU transcriptional activator (TenA AS53_2781 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AS53_2783 ENOG4108VEU Thiamine monophosphate synthase AS53_2784 ENOG41080HI glycine oxidase AS53_2787 ENOG4105D06 uba thif-type nad fad binding protein AS53_2788 ENOG4105DWF phosphomethylpyrimidine kinase AS53_279 ENOG4105DSJ YicC domain protein AS53_2797 ENOG4108INS Transcriptional regulator AS53_28 ENOG4108SVB resolvase AS53_2800 ENOG4105C7N Xanthine uracil vitamin C permease AS53_2807 ENOG4105C5Y PTS System AS53_281 ENOG4105F23 Fibronectin-binding protein AS53_2814 ENOG4108B31 Spore germination protein AS53_2819 ENOG4107Y03 Nitroreductase AS53_282 ENOG4105DC7 peptidase M24 AS53_2820 ENOG4105ED1 spovr family AS53_2825 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AS53_2826 ENOG4105XTG Pfam:DUF156 AS53_2827 ENOG4105VFE sira family AS53_2828 ENOG4107TPS domain protein AS53_2829 ENOG4105VFE sira family AS53_2831 ENOG41085GJ domain protein AS53_2833 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AS53_2834 ENOG41087NI Sulfite exporter TauE/SafE AS53_2836 ENOG4108KGH TRANSCRIPTIONal AS53_2841 ENOG4105EMD TRANSCRIPTIONal AS53_2842 ENOG4105VCP PTS System AS53_2843 ENOG4105VZJ PTS System AS53_2847 ENOG41069ER domain protein AS53_2848 ENOG4107RBB ABC transporter, permease AS53_2849 ENOG4105C19 ABC transporter AS53_2855 ENOG4105WEF catalase AS53_2862 ENOG4107T5V SNARE associated Golgi AS53_2868 ENOG4105CUB amino acid AS53_2869 ENOG4107RWR Sodium hydrogen exchanger AS53_2871 ENOG4106KNT transcriptional regulator AS53_2878 ENOG4108PCN EamA-like transporter family AS53_2879 ENOG4108YXU transcriptional regulator AsnC family AS53_2881 ENOG4105KPY Small multidrug resistance protein AS53_2882 ENOG4105KPY Small multidrug resistance protein AS53_2887 ENOG4105NF4 modulator of drug activity AS53_2888 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AS53_2889 ENOG4105E5W Transporter AS53_2891 ENOG4107RKG DJ-1/PfpI family AS53_2892 ENOG4105CH6 catalase AS53_2894 ENOG4105D5Q Arginine ornithine antiporter AS53_2895 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AS53_2897 ENOG4105C26 Dehydrogenase AS53_2898 ENOG4105BZ1 (ABC) transporter AS53_2899 ENOG4105BZ1 (ABC) transporter AS53_2900 ENOG4105BZ1 (ABC) transporter AS53_2902 ENOG4105DRP amino acid AbC transporter AS53_2903 ENOG4105CDA abc transporter atp-binding protein AS53_2906 ENOG410839P AS53_2913 ENOG4107FQX Alpha-acetolactate decarboxylase AS53_2918 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AS53_2920 ENOG4105D4P Coproporphyrinogen iii oxidase AS53_2923 ENOG4105CHH sulfate transporter AS53_293 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AS53_2931 ENOG4106AKK s-layer domain-containing protein AS53_2933 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AS53_2934 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AS53_2937 ENOG4105CGU Enoyl-CoA hydratase AS53_2940 ENOG4105DER m42 family AS53_2944 ENOG4105CTU Proline racemase AS53_2952 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS53_2955 ENOG4108JQ7 (ABC) transporter AS53_2956 ENOG4105PKS Excinuclease abc c subunit domain protein AS53_2962 ENOG4105CSH Transporter AS53_2964 ENOG4108MRH transcriptional regulatory protein AS53_2973 ENOG4105CDU Replicative dna helicase AS53_298 ENOG4105C34 Pseudouridine synthase AS53_2981 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS53_2991 ENOG4107P5I polyketide synthase AS53_2992 ENOG4108IG5 Transcriptional regulator AS53_2996 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AS53_3 ENOG4107QIV Cytochrome c biogenesis protein AS53_3000 ENOG4105CMT Dihydroxyacetone kinase AS53_3002 ENOG4105CMT Dihydroxyacetone kinase AS53_3003 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AS53_3004 ENOG410847I Transcriptional regulator, BadM Rrf2 family AS53_3009 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AS53_301 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AS53_3022 ENOG4105WN5 stage II sporulation protein AS53_3024 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_3026 ENOG4108MJI response regulator AS53_3027 ENOG4105BZU Histidine kinase AS53_3028 ENOG4105BZU Histidine kinase AS53_303 ENOG4105DBK s4 domain protein AS53_3033 ENOG4105K8R UPF0145 protein AS53_3039 ENOG4107VRP DNA repair exonuclease AS53_304 ENOG41067XK integral membrane protein AS53_3040 ENOG4106D4I domain protein AS53_3041 ENOG4105D7V transposase AS53_3044 ENOG4108IND Tetr family transcriptional regulator AS53_3045 ENOG4105EQ0 Major Facilitator superfamily AS53_3051 ENOG4108MUZ hydrolase AS53_3055 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AS53_3058 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AS53_306 ENOG4105DFA alanine racemase domain protein AS53_3061 ENOG4105EMN RNA polymerase sigma factor AS53_3066 ENOG4105C57 major facilitator superfamily AS53_3067 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS53_3069 ENOG4105EEM helicase AS53_307 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AS53_3076 ENOG4105K59 histidine triad (HIT) protein AS53_308 ENOG4105WR5 sporulation protein, YlmC YmxH family AS53_3083 ENOG410905X membrane-flanked domain protein AS53_3085 ENOG4105CKV Membrane AS53_3095 ENOG410905X membrane-flanked domain protein AS53_3096 ENOG4105CKV Membrane AS53_3097 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AS53_3098 ENOG4105BZ4 penicillin-binding protein AS53_3099 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AS53_310 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_3101 ENOG4105C1Q protoporphyrinogen oxidase AS53_3107 ENOG4105NA0 Transcriptional regulator AS53_3110 ENOG4105ECB domain protein AS53_3116 ENOG4106AXD AS53_3117 ENOG4108RQ5 Beta-lactamase domain-containing protein AS53_3118 ENOG4105DF9 Lipoate-protein, ligase AS53_312 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AS53_3120 ENOG4105CEY Amp-dependent synthetase and ligase AS53_3126 ENOG4105CNA YD repeat protein AS53_313 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AS53_3131 ENOG4105ENX hydrolase AS53_3133 ENOG4107RN3 metallophosphoesterase AS53_3134 ENOG4107TVP HD domain protein AS53_3136 ENOG4108AEY RNA polymerase sigma factor AS53_3137 ENOG41086D8 Transcriptional regulator AS53_314 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AS53_3141 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS53_3146 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AS53_3147 ENOG4105C8Q Methyl-accepting chemotaxis AS53_315 ENOG4105D4A Cell wall formation (By similarity) AS53_3151 ENOG4105ZU5 s-layer protein AS53_3152 ENOG4107QP3 malate synthase g AS53_3155 ENOG4105VEQ Cold shock protein AS53_3158 ENOG4105XVF Competence transcription factor AS53_316 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AS53_3161 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AS53_3162 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AS53_317 ENOG4105CNI cell division protein FtsW AS53_3170 ENOG4105ERH Fumarylacetoacetate hydrolase AS53_3175 ENOG4105CAQ asparagine synthetase AS53_3176 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AS53_3177 ENOG4105CH6 catalase AS53_3178 ENOG4105BZU Histidine kinase AS53_3182 ENOG4105QNR S1 RNA binding domain protein AS53_3184 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AS53_3186 ENOG4107AYK membrAne AS53_3187 ENOG41073B9 AS53_3189 ENOG4108KP7 hydrolase AS53_3191 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AS53_3196 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AS53_3197 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AS53_32 ENOG4105K7K Transcriptional regulator AS53_320 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AS53_3200 ENOG4105C31 Tryptophanyl-tRNA synthetase AS53_3203 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AS53_3204 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS53_3206 ENOG4108JQ7 (ABC) transporter AS53_3207 ENOG4105UQX Mate efflux family protein AS53_321 ENOG4105CJN penicillin-binding protein AS53_3211 ENOG4108ZCF integral membrane protein AS53_3213 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AS53_3215 ENOG4105DPN Oligoendopeptidase f AS53_3218 ENOG4108Z18 K06886 hemoglobin AS53_3219 ENOG4105MIX Adenylate cyclase AS53_322 ENOG4105CJN penicillin-binding protein AS53_3222 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AS53_3223 ENOG4105EMS pseudouridine synthase AS53_3227 ENOG4105CNI cell division protein FtsW AS53_3229 ENOG4105K64 Glycosyl transferase, family 2 AS53_323 ENOG41068DC Essential cell division protein (By similarity) AS53_3233 ENOG4107TVC Glycosyl transferase, family 2 AS53_3237 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AS53_3238 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AS53_3240 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AS53_3249 ENOG4108WVJ 2'-5' rna ligase AS53_3254 ENOG4105CK7 Sodium proline symporter AS53_3255 ENOG4105CRQ synthase (Component I) AS53_3256 ENOG4105DDQ anthranilate synthase AS53_3274 ENOG4105C7S Dehydrogenase AS53_3276 ENOG4105VZ8 Transcriptional regulator AS53_3287 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AS53_3289 ENOG4105DZ1 carboxypeptidase AS53_3290 ENOG4105VFR signal peptidase AS53_3296 ENOG4105C26 Dehydrogenase AS53_3297 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AS53_3298 ENOG4105F38 ABC transporter, permease AS53_3299 ENOG4105D38 putrescine abc transporter AS53_330 ENOG4105KNH Nucleic acid-binding protein AS53_3300 ENOG4107RUE extracellular solute-binding protein family 1 AS53_3302 ENOG4105EYF MMPL domain protein AS53_3304 ENOG4108YBP pseudouridine synthase AS53_3306 ENOG4105K4I Scp-like extracellular AS53_3307 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AS53_3308 ENOG4105CQB FAD linked oxidase domain protein AS53_3311 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_3312 ENOG4105BZU Histidine kinase AS53_3313 ENOG4105JXH GntR family transcriptional regulator AS53_3317 ENOG4106A3R peptidase AS53_3319 ENOG4108QTI )-transporter AS53_3320 ENOG4107TS3 membrane protein, TerC AS53_3321 ENOG4105CZN Potassium uptake protein AS53_3322 ENOG410681C small acid-soluble spore protein AS53_3323 ENOG4108Z7G MaoC domain protein dehydratase AS53_3327 ENOG4105CHR reductase AS53_3329 ENOG4105MWK D-amino acid dehydrogenase, small subunit AS53_3333 ENOG4105C4Y ABC transporter AS53_3335 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AS53_3338 ENOG4107RCV ABC transporter, permease AS53_3339 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AS53_3342 ENOG4105E98 transcriptional regulator DeoR family AS53_3347 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AS53_3348 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AS53_3350 ENOG4105PXI polysaccharide deacetylase AS53_3352 ENOG4105BZU Histidine kinase AS53_3353 ENOG41090MY MarR family Transcriptional regulator AS53_3355 ENOG4106DF1 AS53_3357 ENOG4105BZU Histidine kinase AS53_3359 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AS53_3360 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AS53_3368 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AS53_3369 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AS53_3371 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AS53_3372 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AS53_3373 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AS53_3374 ENOG4105CZV ABC transporter AS53_3376 ENOG4105CJ1 ABC, transporter AS53_3384 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AS53_3385 ENOG4105EA8 2-Nitropropane dioxygenase AS53_3386 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AS53_3388 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AS53_3393 ENOG4105NQC Flavodoxin AS53_340 ENOG4105XSJ toxin secretion phage lysis holin AS53_3400 ENOG4107QMU Mate efflux family protein AS53_3401 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AS53_3407 ENOG4105CZN Potassium uptake protein AS53_3408 ENOG41063Y9 AS53_3409 ENOG4105KBJ sporulation protein ytfj AS53_3414 ENOG4105CM2 brancheD-chain amino acid aminotransferase AS53_3415 ENOG4105C7K acetolactate synthase AS53_3416 ENOG4108ZP8 Acetolactate synthase small subunit AS53_3417 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AS53_3419 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AS53_3424 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AS53_3431 ENOG4107RVV histidinol phosphate phosphatase, hisj family AS53_3434 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AS53_3435 ENOG4105E0M Sulfatase AS53_3437 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AS53_3441 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AS53_3442 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AS53_3444 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AS53_3445 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AS53_3446 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AS53_3447 ENOG4105C8J )-transporter AS53_3451 ENOG4105DFD Na H antiporter AS53_3455 ENOG4105ENE Histidine kinase AS53_3456 ENOG4105WH1 Two component transcriptional regulator luxr family AS53_3460 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AS53_3465 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AS53_3469 ENOG4105CJ3 phosphate transporter AS53_3470 ENOG4107GRR phosphate transport regulator AS53_3471 ENOG4105BZ4 penicillin-binding protein AS53_3474 ENOG4105BZU Histidine kinase AS53_3475 ENOG4105I3N Conserved Protein AS53_3478 ENOG4105BZU Histidine kinase AS53_3485 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AS53_3486 ENOG4105DZ1 carboxypeptidase AS53_3487 ENOG4108JIC nucleoside recognition domain protein AS53_3489 ENOG4105FE9 pseudouridine synthase AS53_3491 ENOG4107TWT Cytochrome c biogenesis protein AS53_3492 ENOG4105CRE cytochrome C AS53_3493 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_3494 ENOG4105BZU Histidine kinase AS53_3495 ENOG4108WBT adenosyltransferase AS53_3498 ENOG4108SAX Membrane AS53_3500 ENOG4105T7X AS53_3501 ENOG4105C9U ATP-dependent DNA helicase RecQ AS53_3502 ENOG4105I7S Abortive infection protein AS53_3504 ENOG4107RGJ metallophosphoesterase AS53_3505 ENOG4107X2D transcriptional regulator, merr family AS53_3506 ENOG4108S6Z Negative regulator of genetic competence AS53_3511 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AS53_3512 ENOG4107RB3 L-asparaginase AS53_3519 ENOG4105S2F AS53_3520 ENOG41065D1 AS53_3526 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AS53_3529 ENOG4105XXQ heptaprenyl diphosphate synthase component I AS53_3531 ENOG4105EAH synthase AS53_3535 ENOG4105CIH Imidazole acetol-phosphate transaminase AS53_3536 ENOG41068YB TPR repeat-containing protein AS53_3539 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AS53_3540 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AS53_3541 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AS53_3547 ENOG4108JYZ YitT family AS53_3548 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AS53_3551 ENOG4105FJR Lmbe family AS53_3552 ENOG4105CPK Glycosyl transferase (Group 1 AS53_3559 ENOG4105DVT helicase AS53_3560 ENOG4105YAC AS53_3564 ENOG4105CSM endonuclease III AS53_3566 ENOG4105BZ4 penicillin-binding protein AS53_357 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AS53_3577 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AS53_3579 ENOG4105DVT helicase AS53_3580 ENOG4105CTD carboxy-peptidase AS53_3583 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AS53_3585 ENOG4105C2W permease AS53_3586 ENOG4105DHF Membrane AS53_3588 ENOG410890F Dynamin family AS53_359 ENOG4105CAR Terminase, large subunit AS53_3590 ENOG4108W0I acetyltransferase AS53_3592 ENOG4105KHC sulfurtransferase AS53_3595 ENOG4106032 Glutathionylspermidine synthase AS53_3609 ENOG4105CPK Glycosyl transferase (Group 1 AS53_3612 ENOG4108SZE gCN5-related N-acetyltransferase AS53_3616 ENOG41081VK Ribonuclease AS53_3629 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AS53_3631 ENOG4107RWR Sodium hydrogen exchanger AS53_3632 ENOG4105CN5 Metallo-Beta-Lactamase AS53_3633 ENOG4108Z5V transcriptional regulator, merr family AS53_3635 ENOG4105H67 Protein of unknown function (DUF421) AS53_3636 ENOG41080C8 DUF218 domain AS53_3647 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AS53_3649 ENOG4107R0U MotA TolQ exbB proton channel AS53_3650 ENOG4105ER2 Ompa motb domain protein AS53_3651 ENOG4107YTP response regulator receiver protein AS53_3652 ENOG4105CBS Chea signal transduction histidine kinase AS53_3653 ENOG4105CBS Chea signal transduction histidine kinase AS53_3654 ENOG4105DD5 Flagellar motor switch protein AS53_3657 ENOG4105BZU Histidine kinase AS53_3661 ENOG4105E1Q flagellar hook-associated protein AS53_3662 ENOG4105DTJ flagellar hook-associated protein AS53_3667 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AS53_3668 ENOG4108ZC9 flagellar basal-body rod protein flgc AS53_3669 ENOG41075Z6 flagellar hook-basal body complex protein fliE AS53_3670 ENOG4107U2N Flagellar M-ring protein AS53_3672 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AS53_3679 ENOG4105BZE flagellar hook protein, FlgE AS53_3683 ENOG4107R88 Chemotaxis protein (CheV) AS53_3685 ENOG4105K64 Glycosyl transferase, family 2 AS53_3691 ENOG4107TVC Glycosyl transferase, family 2 AS53_3696 ENOG4105I03 Flagellin AS53_3697 ENOG4105E4C Lytic transglycosylase catalytic AS53_3698 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AS53_3700 ENOG4105DD5 Flagellar motor switch protein AS53_3702 ENOG4105CN7 Flagellar biosynthetic protein FliP AS53_3703 ENOG4105VS8 Flagellar biosynthetic protein fliq AS53_3705 ENOG4105D00 flagellar biosynthetic protein flhB AS53_3706 ENOG4105D7B Flagellar biosynthesis protein flha AS53_3707 ENOG4105FZW flagellar biosynthesis regulator FlhF AS53_3708 ENOG4105KTQ flagellar basal-body rod protein AS53_3709 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AS53_3714 ENOG4108RZE Tetr family transcriptional regulator AS53_3718 ENOG4105KAC Antibiotic biosynthesis monooxygenase AS53_3723 ENOG4105DUM transcriptional regulator, lysR family AS53_3724 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AS53_3725 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AS53_3726 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AS53_3727 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AS53_3734 ENOG4105CVJ phosphoglycerate mutase AS53_3741 ENOG4105CAQ asparagine synthetase AS53_3745 ENOG4105PGM cation diffusion facilitator family transporter AS53_3747 ENOG4105DRR Transcriptional regulator, GntR family AS53_3748 ENOG4108UZ3 Transporter AS53_3749 ENOG4105CKI cobalamin synthesis protein AS53_3750 ENOG4108PJD permease AS53_3753 ENOG4105DFD Na H antiporter AS53_3754 ENOG4105C9Q fumarate hydratase class II AS53_3758 ENOG4107QJQ Mate efflux family protein AS53_3759 ENOG4107QJQ Mate efflux family protein AS53_376 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AS53_3760 ENOG4105EC3 peptidase S51, dipeptidase E AS53_3765 ENOG4107QIV Cytochrome c biogenesis protein AS53_3772 ENOG4106BRA Membrane AS53_3779 ENOG4105CJ1 ABC, transporter AS53_3783 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AS53_3785 ENOG4108IJ0 Aspartate ammonia-lyase AS53_3786 ENOG4105C6K Malic enzyme AS53_379 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_3799 ENOG4105FVX AS53_3807 ENOG4105CSR polyphosphate kinase 2 AS53_3808 ENOG4105DXI Major Facilitator superfamily AS53_3809 ENOG4105DXI Major Facilitator superfamily AS53_3812 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AS53_3815 ENOG4105EU0 Major facilitator Superfamily AS53_3816 ENOG4105C6T cysteine synthase AS53_3820 ENOG4105C8J )-transporter AS53_3822 ENOG4105X5K response regulator receiver protein AS53_3823 ENOG4105H67 Protein of unknown function (DUF421) AS53_3826 ENOG4106KE4 Dehydrogenase AS53_3830 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AS53_3831 ENOG4105CHR reductase AS53_3832 ENOG4105CM2 brancheD-chain amino acid aminotransferase AS53_3833 ENOG4105C7K acetolactate synthase AS53_3834 ENOG4108ZP8 Acetolactate synthase small subunit AS53_3835 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AS53_3837 ENOG4105C7B Threonine dehydratase AS53_3842 ENOG4105C6X Major Facilitator AS53_3843 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AS53_3845 ENOG4105DY9 regulatoR AS53_3846 ENOG4105CYC Transferase AS53_3850 ENOG4105F6J Alpha beta hydrolase fold AS53_3851 ENOG4108J59 Extracellular solute-binding protein, family 5 AS53_3857 ENOG41068WN AS53_3862 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AS53_3863 ENOG4105C72 UPF0176 protein AS53_3865 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AS53_3867 ENOG4105C0X amino acid AS53_3868 ENOG4105C0X amino acid AS53_3873 ENOG4107RHR regulatoR AS53_3875 ENOG4105D9N nucleoside AS53_3876 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AS53_3882 ENOG4107RAQ aminopeptidase AS53_3883 ENOG4107STQ Multicopper oxidase AS53_3893 ENOG4108T5E Copper resistance protein AS53_3894 ENOG4105KTB nuclear export factor GLE1 AS53_3896 ENOG4107RT3 EamA-like transporter family AS53_3897 ENOG4105GZI Transcriptional regulator AS53_3898 ENOG4108Z40 Transcriptional regulator AS53_3899 ENOG4107ZXU DSBA oxidoreductase AS53_390 ENOG4108IMY Transcriptional regulator AS53_3900 ENOG4108TVJ Nitroreductase AS53_3902 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AS53_3903 ENOG4106F5Q Membrane AS53_3904 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AS53_3906 ENOG4105CKI cobalamin synthesis protein AS53_3910 ENOG4108Z7G MaoC domain protein dehydratase AS53_3911 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AS53_3913 ENOG4105C0Z ABC transporter AS53_3914 ENOG4108IV0 ABC, transporter AS53_3915 ENOG4105C32 Amino acid ABC transporter (Permease) AS53_3917 ENOG4105SKE transcriptional Regulator LysR family AS53_3919 ENOG4105MDS 4-oxalocrotonate tautomerase AS53_3921 ENOG4105YGB Transcriptional regulator AS53_3923 ENOG4105C4M (Ubiquinol oxidase) subunit I AS53_3924 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AS53_3925 ENOG4108JJ9 ABC, transporter AS53_3926 ENOG4108JJ8 (ABC) transporter AS53_3934 ENOG4105BZ1 (ABC) transporter AS53_3935 ENOG4105BZ1 (ABC) transporter AS53_3936 ENOG4105EFI regulatoR AS53_3937 ENOG4105BZU Histidine kinase AS53_3941 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AS53_3942 ENOG4108ZJ4 polysaccharide deacetylase AS53_3946 ENOG4105D6E homoserine dehydrogenase AS53_3951 ENOG4108KGH TRANSCRIPTIONal AS53_3953 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS53_3954 ENOG4105BZU Histidine kinase AS53_3955 ENOG4107VMI polysaccharide deacetylase AS53_3957 ENOG4105KT7 mgtC SapB transporter AS53_3958 ENOG4105VRR gCN5-related N-acetyltransferase AS53_3960 ENOG4105DUU IucA IucC family protein AS53_3961 ENOG4105CEY Amp-dependent synthetase and ligase AS53_3964 ENOG4108WBH protein TIM barrel AS53_3965 ENOG4105YWU small acid-soluble spore protein AS53_3966 ENOG4107RCC Major Facilitator Superfamily AS53_3968 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AS53_3979 ENOG4105KRN Transcriptional regulator, abrb family AS53_398 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) AS53_3981 ENOG4105YVS arsR family transcriptional regulator AS53_3982 ENOG4107SET aldo keto reductase AS53_3983 ENOG4107XZQ multidrug resistance protein AS53_3988 ENOG4105C8Q Methyl-accepting chemotaxis AS53_3991 ENOG4108K88 Membrane AS53_3992 ENOG4108WPJ Ferritin-like domain AS53_3995 ENOG4105DEN Luciferase family AS53_3999 ENOG4107QM2 Aldo Keto reductase AS53_40 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AS53_400 ENOG41063PX domain protein AS53_4000 ENOG4105CKI cobalamin synthesis protein AS53_401 ENOG4105D78 K07001 NTE family protein AS53_4011 ENOG4105DSE periplasmic solute binding protein AS53_4013 ENOG4105K4T epimerase AS53_4015 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AS53_4020 ENOG4105CVJ phosphoglycerate mutase AS53_4024 ENOG4107T5V SNARE associated Golgi AS53_4027 ENOG4108PJD permease AS53_4029 ENOG4108S4H thioesterase Superfamily protein AS53_403 ENOG4105H20 Sporulation integral membrane protein YlbJ AS53_4030 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AS53_4034 ENOG4105SXS Protein of unknown function (DUF456) AS53_4035 ENOG4105C37 (CBS) domain AS53_4039 ENOG4108Z7R Chaperone CsaA AS53_404 ENOG4106H78 methyltransferase AS53_4043 ENOG4108ZRV stage ii sporulation protein p AS53_4045 ENOG4108VXD carboxy-peptidase AS53_4047 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AS53_4052 ENOG4108X4Q Hydrolase AS53_4054 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AS53_4055 ENOG4107RBS Methyltransferase AS53_4058 ENOG41087PP glycosyltransferase MGT family AS53_4059 ENOG4108JYZ YitT family AS53_4060 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AS53_4066 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AS53_4075 ENOG4105KBJ sporulation protein ytfj AS53_4080 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AS53_4084 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AS53_4085 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase AS53_4087 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AS53_4088 ENOG4105EMN RNA polymerase sigma factor AS53_409 ENOG4107TB6 phosphoglycerate mutase AS53_4093 ENOG4108V06 Glutathione peroxidase AS53_4096 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AS53_41 ENOG4105XSJ toxin secretion phage lysis holin AS53_4100 ENOG4108IUE nitrate reductase beta subunit AS53_4101 ENOG4105R3A Nitrate reductase AS53_4106 ENOG4107V6Q Cyclic nucleotide-binding domain AS53_4107 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AS53_4108 ENOG4105D06 uba thif-type nad fad binding protein AS53_4109 ENOG4105CVM Molybdenum cofactor synthesis domain protein AS53_4110 ENOG4108ZAF Molybdopterin AS53_4115 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AS53_4116 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AS53_4117 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AS53_4118 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AS53_4119 ENOG4108IFG nitrite reductase, (NAD(P)H) AS53_412 ENOG4106UY4 Inherit from COG: Scp-like extracellular AS53_4120 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AS53_4127 ENOG4105MCT stage V sporulation protein S AS53_4130 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AS53_4134 ENOG4105C5H ABC transporter AS53_4137 ENOG4108UUM single-stranded DNA-binding protein AS53_4140 ENOG41061H0 Monooxygenase AS53_4144 ENOG4107YX5 Pfam:DUF548 AS53_4145 ENOG4105C75 arginyL-tRNA synthetase AS53_4151 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AS53_4154 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AS53_4155 ENOG4105C5S asparaginyl-tRNA synthetase AS53_4159 ENOG4105EC2 ftsk spoIIIe AS53_4178 ENOG4105BZW Glycerate kinase AS53_4179 ENOG4107QPK )-transporter AS53_4180 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_4181 ENOG41062D9 Histidine kinase AS53_4184 ENOG4105C8J )-transporter AS53_4188 ENOG4107XGZ Hydrolase AS53_4189 ENOG4105CY2 Citrate transporter AS53_4190 ENOG4105C0A alcohol dehydrogenase AS53_4193 ENOG4105KD7 acetyltransferase AS53_4195 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AS53_4200 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AS53_4204 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AS53_4207 ENOG4107RVG penicillin-binding protein AS53_4208 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AS53_4209 ENOG4105E9Q Acyl-transferase AS53_4210 ENOG4108UT2 hemolysin iii AS53_4212 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AS53_4214 ENOG4108RCR degv family AS53_4215 ENOG4105E8R UPF0173 metal-dependent hydrolase AS53_4216 ENOG4108KF3 Electron transport protein SCO1 SenC AS53_4217 ENOG4107Y70 Heat shock protein AS53_4218 ENOG4105CAQ asparagine synthetase AS53_422 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AS53_4222 ENOG4108MES Periplasmic binding protein AS53_4223 ENOG4105F0I Aminotransferase AS53_423 ENOG4105CNI cell division protein FtsW AS53_4230 ENOG4105D8X mechanosensitive ion channel AS53_4231 ENOG4105BZU Histidine kinase AS53_4232 ENOG4105WH1 Two component transcriptional regulator luxr family AS53_4234 ENOG4106KNT transcriptional regulator AS53_4242 ENOG4105CMG Carbohydrate kinase AS53_4243 ENOG4105CMG Carbohydrate kinase AS53_4249 ENOG4108IJ8 ABC transporter AS53_4250 ENOG4105E90 ABC transporter AS53_4257 ENOG4105C37 (CBS) domain AS53_426 ENOG4108IAB Phoh family AS53_4262 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AS53_4265 ENOG4107S4Y M20 DapE family protein YgeY AS53_4266 ENOG4108TSC N-acetyltransferase AS53_4267 ENOG4108JUB Transcriptional regulator AS53_4268 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AS53_4276 ENOG4108N23 SpoOM-related protein AS53_4278 ENOG410841Q phosphoesterase PA-phosphatase related protein AS53_4279 ENOG4105SZ6 Thioredoxin AS53_4281 ENOG4108IBT Inherit from COG: transposase AS53_430 ENOG4105QA2 AS53_4300 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AS53_4308 ENOG4105BZ4 penicillin-binding protein AS53_4309 ENOG4105CZM Major Facilitator AS53_431 ENOG4105CI3 gtp-binding protein typa AS53_4310 ENOG4105W8X HesB YadR YfhF-family protein AS53_4312 ENOG4105DXD 2-methylcitrate dehydratase AS53_4313 ENOG4105CR4 methylisocitrate lyase AS53_4314 ENOG4105C1G acyl-Coa dehydrogenase AS53_4315 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AS53_4317 ENOG4105N14 lysine exporter protein LysE YggA AS53_4318 ENOG4105E39 Enoyl-CoA hydratase AS53_4321 ENOG4107RFY SbcCD D subunit AS53_4322 ENOG4105EYH Exonuclease AS53_4326 ENOG4105FCD Major Facilitator AS53_4327 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AS53_4328 ENOG4105E4F Isochorismate synthase AS53_4329 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AS53_433 ENOG4105ECY inositol monophosphatase AS53_4330 ENOG4105WQI isochorismatase AS53_4331 ENOG4105CEY Amp-dependent synthetase and ligase AS53_4332 ENOG4105WQT MbtH domain protein AS53_4333 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS53_4336 ENOG4105K70 DNA-binding protein AS53_4340 ENOG4105BZG amino acid carrier protein AS53_4344 ENOG4105FE9 pseudouridine synthase AS53_4345 ENOG4105C22 threonyL-tRNA synthetase AS53_4349 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AS53_4355 ENOG4108D32 Methyltransferase AS53_4361 ENOG41081I9 integral membrane protein AS53_4364 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AS53_4366 ENOG4105EYF MMPL domain protein AS53_437 ENOG4105CXN decarboxylase AS53_4371 ENOG4105WCN acetyltransferase AS53_4377 ENOG4105C1Q protoporphyrinogen oxidase AS53_4379 ENOG41068WN AS53_4381 ENOG4105VEQ Cold shock protein AS53_4385 ENOG410667J hydrolase AS53_4393 ENOG4107V2S Transcriptional regulator AS53_4394 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AS53_4397 ENOG4105DND Transcriptional regulator AS53_4398 ENOG4108RPX mosc domain containing protein AS53_4401 ENOG4105BZ1 (ABC) transporter AS53_4402 ENOG4105BZ1 (ABC) transporter AS53_4406 ENOG4108JCI Transcriptional regulator AS53_4411 ENOG4108KPJ rna polymerase sigma factor AS53_4416 ENOG4105F32 YngK protein AS53_4421 ENOG4105RD7 BadF BadG BcrA BcrD AS53_4423 ENOG4107STF Involved in phosphonate degradation (By similarity) AS53_4426 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AS53_4429 ENOG4105C1J atp-dependent rna helicase AS53_4431 ENOG4108RZE Tetr family transcriptional regulator AS53_4435 ENOG41088CC tellurite resistance protein tehB AS53_4437 ENOG4108I0C methyltransferase AS53_4438 ENOG4107RA9 decarboxylase AS53_4439 ENOG41090HR transcriptional regulator AS53_4447 ENOG4105CIN aminoacyl-histidine dipeptidase AS53_4453 ENOG4107RF6 penicillin-binding protein AS53_4454 ENOG4107RF6 penicillin-binding protein AS53_4455 ENOG4107RF6 penicillin-binding protein AS53_4457 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AS53_4458 ENOG4105ETE Transcriptional regulator (LacI family AS53_4459 ENOG4105IE8 Alpha-ketoglutarate permease AS53_446 ENOG4105C7S Dehydrogenase AS53_4460 ENOG4105CK5 oxidoreductase AS53_4465 ENOG4105D2N Aldolase AS53_4466 ENOG4105DH8 myo-inositol catabolism AS53_447 ENOG4105CPP Dehydrogenase, E1 component AS53_4470 ENOG4105CGH 5'-nucleotidase AS53_4471 ENOG4105CGH 5'-nucleotidase AS53_4474 ENOG4105VZ8 Transcriptional regulator AS53_4477 ENOG4108VXD carboxy-peptidase AS53_4482 ENOG41067SE Tetr family transcriptional regulator AS53_4483 ENOG4105C5H ABC transporter AS53_4485 ENOG4105BZU Histidine kinase AS53_4487 ENOG4106ANW SMI1_KNR4 AS53_4488 ENOG4105CEP NADH dehydrogenase AS53_4489 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AS53_4492 ENOG4105CJ1 ABC, transporter AS53_4497 ENOG4105C1G acyl-Coa dehydrogenase AS53_4498 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AS53_4499 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AS53_450 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AS53_4500 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AS53_4501 ENOG4105E39 Enoyl-CoA hydratase AS53_4502 ENOG4107QX3 carboxylase AS53_4503 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AS53_4505 ENOG4105WCN acetyltransferase AS53_4506 ENOG4105DBI uridine monophosphokinase AS53_4509 ENOG4105DZ1 carboxypeptidase AS53_451 ENOG4108X4Q Hydrolase AS53_4512 ENOG4105T9C HD domain AS53_4514 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AS53_4523 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AS53_4523 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AS53_4526 ENOG4105FQP Beta-lactamase AS53_4528 ENOG4107Y80 Major Facilitator superfamily AS53_453 ENOG4105CN5 Metallo-Beta-Lactamase AS53_4532 ENOG4105CUV Homoserine Kinase AS53_4538 ENOG4105CPQ Dehydrogenase AS53_454 ENOG4107ZYR domain protein AS53_4541 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AS53_4542 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AS53_4563 ENOG4105ETU transcriptional activator (TenA AS53_4586 ENOG410667J hydrolase AS53_4588 ENOG4105BZU Histidine kinase AS53_4589 ENOG4107RF6 penicillin-binding protein AS53_4593 ENOG4108JJB ABC transporter AS53_4596 ENOG4108HGU Histidine kinase AS53_4599 ENOG4105CB2 alcohol dehydrogenase AS53_4600 ENOG4105CJN penicillin-binding protein AS53_4602 ENOG4105FQP Beta-lactamase AS53_4608 ENOG4108V4B ThiJ pfpI AS53_461 ENOG4108XRC Protein of unknown function (DUF458) AS53_4613 ENOG4107Y80 Major Facilitator superfamily AS53_4617 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AS53_4622 ENOG4107Y9U Membrane AS53_4629 ENOG4105FCD Major Facilitator AS53_463 ENOG4107IN1 Protein of unknown function (DUF1797) AS53_4631 ENOG4105E09 nadh pyrophosphatase AS53_4632 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AS53_4633 ENOG4108Z4K mutator MutT protein AS53_4640 ENOG4108XI2 Domain of unknown function (DUF1963) AS53_4646 ENOG4108NRW Phospholipase, patatin family AS53_4647 ENOG4105KWG Pfam:DUF1696 AS53_4654 ENOG4105PKS Excinuclease abc c subunit domain protein AS53_466 ENOG4105EPM Diguanylate phosphodiesterase AS53_4662 ENOG4107VFR oxidoreductase AS53_4667 ENOG4105PAD Hydrolase AS53_467 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AS53_4672 ENOG4105DY8 decarboxylase AS53_4675 ENOG4108IUM Glycogen debranching enzyme AS53_4680 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AS53_4682 ENOG4105FDR Membrane AS53_4689 ENOG4108V3A UPF0421 protein AS53_4693 ENOG4105MSI germination protein ypeb AS53_4697 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AS53_4698 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AS53_4699 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AS53_470 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AS53_4700 ENOG4107Z3H Transcriptional regulator, TetR family AS53_4706 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AS53_4710 ENOG4105E98 transcriptional regulator DeoR family AS53_4714 ENOG41062ES Transcriptional regulator AS53_4719 ENOG4107QKR Dehydrogenase AS53_472 ENOG4105UIN AS53_4721 ENOG4107RUY (E1 component), alpha subunit AS53_4723 ENOG4105E1F short-chain dehydrogenase reductase AS53_4724 ENOG4105RHY Pfam:UPF0157 AS53_4730 ENOG4107SQ8 Glycine betaine AS53_4731 ENOG4108IJ7 Glycine betaine AS53_4736 ENOG4105E66 phosphoriboisomerase A AS53_4737 ENOG41082BV acetyltransferase AS53_4738 ENOG4108M1A Chitin-binding protein AS53_4747 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AS53_4758 ENOG4105EEM helicase AS53_4762 ENOG4105C9U ATP-dependent DNA helicase RecQ AS53_4771 ENOG4108M1A Chitin-binding protein AS53_4774 ENOG4105BZG amino acid carrier protein AS53_4775 ENOG4105C26 Dehydrogenase AS53_4776 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AS53_4777 ENOG4105CTU Proline racemase AS53_4778 ENOG4105CTU Proline racemase AS53_4779 ENOG41080HI glycine oxidase AS53_4786 ENOG4107T5V SNARE associated Golgi AS53_4789 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AS53_4790 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AS53_4793 ENOG4105DTQ mandelate racemase muconate lactonizing AS53_4801 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AS53_4802 ENOG4105BZU Histidine kinase AS53_4803 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_4810 ENOG4105DPN Oligoendopeptidase f AS53_4813 ENOG4105EPR degv family AS53_4821 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AS53_4822 ENOG4106K7D Major facilitator family transporter AS53_4826 ENOG4107BMA Transglycosylase associated protein AS53_4829 ENOG41089UC methyltransferase, type 11 AS53_483 ENOG4108HGU Histidine kinase AS53_4835 ENOG4105CHM Aminotransferase AS53_4841 ENOG4105DVE abc transporter atp-binding protein AS53_485 ENOG4105CHM Aminotransferase AS53_4850 ENOG4105C02 permease AS53_4852 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AS53_4853 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AS53_4854 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AS53_4859 ENOG4105E09 nadh pyrophosphatase AS53_486 ENOG4105FKQ transcriptional regulator AS53_4863 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AS53_487 ENOG4105EG2 ABC transporter, permease AS53_4873 ENOG4107VC0 DNA alkylation repair enzyme AS53_4875 ENOG4107VMI polysaccharide deacetylase AS53_4877 ENOG4108ZCF integral membrane protein AS53_4878 ENOG4105E0M Sulfatase AS53_4879 ENOG4105C5H ABC transporter AS53_4881 ENOG4105EYF MMPL domain protein AS53_4882 ENOG4105EYF MMPL domain protein AS53_4883 ENOG41082JN Transcriptional regulator AS53_4887 ENOG4105CIH Imidazole acetol-phosphate transaminase AS53_4888 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AS53_4889 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AS53_489 ENOG4107FKK extracellular solute-binding protein family 1 AS53_4897 ENOG41069ER domain protein AS53_4899 ENOG4105EMN RNA polymerase sigma factor AS53_4905 ENOG4105D4B ABC, transporter AS53_4907 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AS53_4909 ENOG4105DKT Transcriptional regulator AS53_491 ENOG4105CG3 alpha amylase, catalytic region AS53_4910 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AS53_4913 ENOG41061GT Aldolase AS53_4917 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AS53_4923 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AS53_4924 ENOG4105II7 pyrroline-5-carboxylate reductase AS53_4926 ENOG4107258 Transcriptional regulator AS53_4928 ENOG4105E0Y RtcB Protein AS53_4929 ENOG4105ECK Fatty Acid Desaturase AS53_4930 ENOG4105G6Z alkaline phosphatase AS53_4932 ENOG4105VMP Transcriptional regulator AS53_4935 ENOG41090T1 Membrane AS53_4937 ENOG4108WCX response regulator AS53_4939 ENOG41068WN AS53_4944 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AS53_4949 ENOG4105CKK Glycosyl transferase, family 2 AS53_4954 ENOG4105CKK Glycosyl transferase, family 2 AS53_4956 ENOG4105C8Y Acetylornithine aminotransferase AS53_4965 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AS53_4967 ENOG4108TVJ Nitroreductase AS53_4968 ENOG4105FS7 Transcriptional regulator AS53_4975 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AS53_4977 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AS53_4983 ENOG4108XET gCN5-related N-acetyltransferase AS53_4999 ENOG410635A Membrane AS53_5 ENOG4107RSM transcriptional regulator AS53_500 ENOG4105CHU acetyl-coa acetyltransferase AS53_5000 ENOG4105KNA -acetyltransferase AS53_5001 ENOG4108IQI permease AS53_5003 ENOG4105F1N DNA alkylation repair AS53_5011 ENOG4107RF6 penicillin-binding protein AS53_5013 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AS53_5020 ENOG4105P4J Allophanate hydrolase, subunit 1 AS53_5021 ENOG4107258 Transcriptional regulator AS53_5023 ENOG4106N3A copper homeostasis protein cutc AS53_5024 ENOG4108ZRV stage ii sporulation protein p AS53_5025 ENOG4108ZHR arsR family transcriptional regulator AS53_5027 ENOG4105FDT acyl-CoA dehydrogenase AS53_5031 ENOG4105DWD nucleoside recognition domain protein AS53_5037 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AS53_5052 ENOG4105E2A Dehydrogenase AS53_5055 ENOG4108IJ0 Aspartate ammonia-lyase AS53_5056 ENOG4105HDK L-asparaginase AS53_5057 ENOG4108IMY Transcriptional regulator AS53_5059 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AS53_5060 ENOG4105CUB amino acid AS53_5062 ENOG4105II7 pyrroline-5-carboxylate reductase AS53_5064 ENOG4105C6K Malic enzyme AS53_5066 ENOG4108NHD germination protein AS53_5067 ENOG4108NHD germination protein AS53_5068 ENOG4108Q8B Spore germination protein AS53_507 ENOG4105K7K Transcriptional regulator AS53_5073 ENOG4105CSV Glutaminase AS53_508 ENOG4105DTD Dehydrogenase AS53_5081 ENOG4105CGH 5'-nucleotidase AS53_5082 ENOG4105CH6 catalase AS53_5084 ENOG4105CHJ isochorismatase hydrolase AS53_5090 ENOG41090MY MarR family Transcriptional regulator AS53_5098 ENOG4108606 TspO/MBR family AS53_5099 ENOG4105CVP deoxyribo-dipyrimidine photolyase AS53_510 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AS53_5102 ENOG4108TWJ NADH dehydrogenase subunit 5 AS53_5103 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AS53_5105 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AS53_5106 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AS53_5107 ENOG4105DSE periplasmic solute binding protein AS53_5108 ENOG4105CC5 ABC transporter AS53_5109 ENOG4105DIK (ABC) transporter AS53_5115 ENOG4105D6J arsenicaL-resistance protein AS53_5116 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AS53_5117 ENOG41085FC arsR family transcriptional regulator AS53_512 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AS53_5121 ENOG4105F7F Chaperone AS53_5123 ENOG4105CHR reductase AS53_5124 ENOG4108YXU transcriptional regulator AsnC family AS53_5138 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AS53_5139 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS53_5141 ENOG4105IIP Membrane AS53_5144 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_5145 ENOG41062D9 Histidine kinase AS53_5150 ENOG4105K6H D-cysteine desulfhydrase AS53_5156 ENOG4105VZ8 Transcriptional regulator AS53_5159 ENOG4108NNI Beta-lactamase domain-containing protein AS53_5160 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AS53_5162 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AS53_5163 ENOG4105JQZ Methyltransferase AS53_5166 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AS53_5167 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AS53_517 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AS53_5170 ENOG4105BZU Histidine kinase AS53_5173 ENOG4108U05 Transcriptional regulator AS53_5174 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 AS53_5176 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AS53_5177 ENOG4105DJB Major Facilitator Superfamily AS53_5178 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AS53_5179 ENOG4107QR9 Iron-sulfur cluster binding protein AS53_5181 ENOG4106P55 Transcriptional regulator AS53_5183 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AS53_5189 ENOG4105TRI Hydrolase AS53_5197 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AS53_520 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AS53_5204 ENOG4107QJQ Mate efflux family protein AS53_5207 ENOG4105MZU cell filamentation protein AS53_5208 ENOG4105EQ0 Major Facilitator superfamily AS53_5209 ENOG4108JGH Tetr family transcriptional regulator AS53_521 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AS53_5212 ENOG4105C44 Serine transporter AS53_5213 ENOG4105EJQ L-serine dehydratase AS53_5215 ENOG4108JPW Aminotransferase AS53_5218 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AS53_522 ENOG4106TD9 Diguanylate cyclase AS53_5220 ENOG4105DVH amino acid AS53_5223 ENOG4108JQ1 Dehydrogenase AS53_5227 ENOG4108AEY RNA polymerase sigma factor AS53_5230 ENOG41082W1 Cupin 2, conserved barrel domain protein AS53_5231 ENOG410874W AraC family transcriptional regulator AS53_5234 ENOG4105HIR S-layer domain protein AS53_5242 ENOG4108ISG Major Facilitator AS53_5244 ENOG4107MII Sugar-specific transcriptional regulator TrmB AS53_5245 ENOG4105CZM Major Facilitator AS53_5249 ENOG4105DA5 (ABC) transporter AS53_5250 ENOG41069JR AS53_5252 ENOG4105RXJ AS53_5253 ENOG4105KPY Small multidrug resistance protein AS53_5254 ENOG4105KBX Transcriptional regulator, TetR family AS53_5256 ENOG4105CRW Short chain fatty acid transporter AS53_5258 ENOG4105DYS nad(p)h dehydrogenase (quinone) AS53_526 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AS53_5264 ENOG4108JJB ABC transporter AS53_5265 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AS53_5270 ENOG4108K8S endonuclease I AS53_5273 ENOG41067QW Transcriptional regulator AS53_5275 ENOG4108Z66 YbaK ebsC protein AS53_5276 ENOG4105CUT histidyl-tRNA synthetase AS53_5279 ENOG4105KVH Transcriptional regulator AS53_5280 ENOG4108RCM Nitroreductase AS53_5284 ENOG4108PSK reductase AS53_5286 ENOG4105CJ1 ABC, transporter AS53_529 ENOG4105CID antiterminator AS53_5298 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AS53_5299 ENOG4105DKQ ROK family AS53_5300 ENOG4106UW1 Major Facilitator superfamily AS53_5301 ENOG4108UW5 maltose o-acetyltransferase AS53_5303 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AS53_5305 ENOG4105C31 Tryptophanyl-tRNA synthetase AS53_5306 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AS53_531 ENOG4105FDP GntR family transcriptional regulator AS53_5311 ENOG4105DMQ Methyltransferase AS53_5313 ENOG4105EV4 Multidrug resistance protein mdtH AS53_5319 ENOG4105C37 (CBS) domain AS53_5322 ENOG4105DDN Pentapeptide repeat-containing protein AS53_5323 ENOG4105XDF Protein of unknown function (DUF1272) AS53_5324 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AS53_5325 ENOG4105CMG Carbohydrate kinase AS53_5326 ENOG4105C6Z Gluconate AS53_5327 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AS53_533 ENOG4105CE4 GlcNAc 6-P deacetylase AS53_5330 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AS53_5331 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AS53_5332 ENOG4105CIS alcohol dehydrogenase AS53_5333 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AS53_5336 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AS53_5337 ENOG4105D4Y metalloprotease AS53_5341 ENOG4105CV8 reductase AS53_5342 ENOG4105F27 Major Facilitator AS53_5345 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AS53_5346 ENOG4105C44 Serine transporter AS53_5352 ENOG4105KVH Transcriptional regulator AS53_5353 ENOG4108TZY GntR Family Transcriptional Regulator AS53_5354 ENOG4105D9R oxidoreductase AS53_5356 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AS53_5357 ENOG4105KVH Transcriptional regulator AS53_5358 ENOG4105KVH Transcriptional regulator AS53_5365 ENOG4105JAB phenazine biosynthesis protein, phzf family AS53_5367 ENOG4105CHR reductase AS53_5371 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AS53_5372 ENOG4105KVH Transcriptional regulator AS53_5376 ENOG4108ZJ4 polysaccharide deacetylase AS53_5386 ENOG4105KAF membrAne AS53_5391 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AS53_5395 ENOG4107YXZ hydrolase, family 25 AS53_540 ENOG4107ZE5 PPIases accelerate the folding of proteins AS53_5400 ENOG4105ED2 Beta-lactamase AS53_5402 ENOG4105H3G oxidoreductase AS53_5409 ENOG4105CIS alcohol dehydrogenase AS53_541 ENOG4105PTM secreted protein AS53_5416 ENOG4108TN2 lmbE family AS53_5418 ENOG4107R3E Citrate transporter AS53_542 ENOG4105J7I hydrolase AS53_5422 ENOG4108MES Periplasmic binding protein AS53_5424 ENOG4105EHG Permease protein AS53_5425 ENOG4105DQ5 transport system permease protein AS53_5426 ENOG4105NX3 Membrane AS53_5427 ENOG4107ZY0 Phenazine biosynthesis-like protein AS53_5431 ENOG4107CUJ Protein of unknown function (DUF2690) AS53_5433 ENOG4107V2S Transcriptional regulator AS53_5437 ENOG4105C98 muts2 protein AS53_5439 ENOG4105E5K Alpha-amylase AS53_544 ENOG4105G6R Stage v sporulation protein ae AS53_5440 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AS53_5443 ENOG4108A04 Beta-lactamase AS53_5449 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AS53_5453 ENOG41082BM Transcriptional regulator, arsr family AS53_5454 ENOG4105CIS alcohol dehydrogenase AS53_546 ENOG4105CZ3 stage V sporulation protein ad AS53_5460 ENOG4105RHY Pfam:UPF0157 AS53_5462 ENOG4105C09 Bile acid AS53_5463 ENOG4105CQB FAD linked oxidase domain protein AS53_5467 ENOG4108UT6 Transferase hexapeptide repeat containing protein AS53_547 ENOG41090VF Stage v sporulation protein ac AS53_5471 ENOG4105E39 Enoyl-CoA hydratase AS53_5473 ENOG4105KT7 mgtC SapB transporter AS53_5475 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AS53_5476 ENOG41073R8 VanW family AS53_5478 ENOG4108R1P AS53_5482 ENOG4105VEQ Cold shock protein AS53_5486 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AS53_5490 ENOG410904N short-chain dehydrogenase reductase AS53_5492 ENOG4106IQC argininosuccinate lyase AS53_5495 ENOG4108IA2 Sodium pantothenate symporter AS53_5496 ENOG4105RG0 Membrane AS53_5497 ENOG4105C26 Dehydrogenase AS53_5498 ENOG4105CHR reductase AS53_5500 ENOG4105EWU Squalene--hopene cyclase AS53_5502 ENOG4105FR1 rard protein AS53_5503 ENOG410696E Membrane AS53_5506 ENOG4105D1F ATP-binding protein AS53_5508 ENOG4108ZAF Molybdopterin AS53_5509 ENOG4105CVM Molybdenum cofactor synthesis domain protein AS53_551 ENOG4105C8J )-transporter AS53_5510 ENOG4105D06 uba thif-type nad fad binding protein AS53_5511 ENOG4105TMB Formate nitrite transporter AS53_5513 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AS53_5514 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AS53_5516 ENOG4108JB9 formate dehydrogenase AS53_5517 ENOG4108JB9 formate dehydrogenase AS53_5519 ENOG4105E1K spore germination protein AS53_552 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_5531 ENOG4107QJT sodium dicarboxylate symporter AS53_5532 ENOG4108KGH TRANSCRIPTIONal AS53_5534 ENOG4105EMN RNA polymerase sigma factor AS53_5538 ENOG4105CIG ABC transporter AS53_554 ENOG41082AN stage II sporulation protein AS53_5540 ENOG4105D9R oxidoreductase AS53_5542 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AS53_5543 ENOG4105K4P CoA-binding domain protein AS53_5544 ENOG4105C0H protease AS53_5545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_5547 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AS53_5548 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AS53_5549 ENOG4105W8X HesB YadR YfhF-family protein AS53_555 ENOG4105DZ1 carboxypeptidase AS53_5555 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AS53_5556 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AS53_5558 ENOG4108JJA ABC, transporter AS53_5559 ENOG4108I0Z Aconitate hydratase AS53_556 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AS53_5564 ENOG4105E5W Transporter AS53_5566 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AS53_557 ENOG4105DVE abc transporter atp-binding protein AS53_5570 ENOG4107F3J Amp-dependent synthetase and ligase AS53_5571 ENOG4107ZYJ bioY protein AS53_5572 ENOG4105CEY Amp-dependent synthetase and ligase AS53_5581 ENOG4107AYK membrAne AS53_5583 ENOG4105BZU Histidine kinase AS53_5584 ENOG4105FBA Phospholipase Carboxylesterase AS53_5585 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AS53_5586 ENOG4105CK7 Sodium proline symporter AS53_5587 ENOG4105CBC glutamate synthase AS53_5588 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AS53_5589 ENOG4108VJ1 Transcriptional regulator (CarD family AS53_5590 ENOG4108903 Formimidoylglutamase AS53_5595 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AS53_5613 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AS53_5620 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AS53_5622 ENOG4108MEK Metal-binding protein YodA AS53_5624 ENOG4105DQ6 Transposase AS53_5626 ENOG4105DQ6 Transposase AS53_5629 ENOG4105DQ6 Transposase AS53_563 ENOG4105D7N magnesium and cobalt transport protein CorA AS53_5630 ENOG4105DQ6 Transposase AS53_5632 ENOG4108IBT Inherit from COG: transposase AS53_5639 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AS53_5641 ENOG4105KRN Transcriptional regulator, abrb family AS53_5668 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AS53_5677 ENOG4105DQ6 Transposase AS53_568 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AS53_5683 ENOG4105C6Y Udp-glucose 6-dehydrogenase AS53_5684 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AS53_5688 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AS53_5689 ENOG4106AKK s-layer domain-containing protein AS53_5695 ENOG4105DHF Membrane AS53_570 ENOG4105I3K Ferric uptake regulator, Fur family AS53_571 ENOG4105MZ9 stage II sporulation protein m AS53_5745 ENOG4105CNU cell division protein FtsK AS53_575 ENOG4105CPC Aldo Keto reductase AS53_5761 ENOG4106JUT Streptomycin 3''-adenylyltransferase AS53_577 ENOG4105RHY Pfam:UPF0157 AS53_5773 ENOG4105EKQ RNA-directed DNA polymerase AS53_5794 ENOG4105EKQ RNA-directed DNA polymerase AS53_581 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AS53_5820 ENOG4105K4H Nlp p60 protein AS53_585 ENOG4108YM7 Gcn5-related n-acetyltransferase AS53_5854 ENOG4107QJE Chromosome Partitioning Protein AS53_5859 ENOG4105DQ6 Transposase AS53_5866 ENOG4105EWC Purine nucleoside phosphorylase AS53_5884 ENOG4105C3F Signal peptidase i AS53_589 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AS53_5891 ENOG4105N14 lysine exporter protein LysE YggA AS53_5897 ENOG4108J59 Extracellular solute-binding protein, family 5 AS53_590 ENOG4108R6K riboflavin synthase, subunit alpha AS53_5901 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AS53_5911 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AS53_5912 ENOG4105C9U ATP-dependent DNA helicase RecQ AS53_594 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AS53_595 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AS53_596 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AS53_597 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AS53_599 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AS53_6 ENOG4105VAW lrga family AS53_601 ENOG4105DFD Na H antiporter AS53_602 ENOG4105CGH 5'-nucleotidase AS53_610 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AS53_613 ENOG4108IXY short-chain dehydrogenase reductase AS53_614 ENOG41069FQ Metallo-beta-lactamase superfamily AS53_616 ENOG4105II7 pyrroline-5-carboxylate reductase AS53_617 ENOG4105EJQ L-serine dehydratase AS53_621 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AS53_623 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AS53_624 ENOG4105D9U N-acetyltransferase AS53_626 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AS53_627 ENOG4108QEG Membrane AS53_628 ENOG4105CDA abc transporter atp-binding protein AS53_629 ENOG4105E5Q amino acid AbC transporter AS53_630 ENOG4108HW3 (ABC) transporter AS53_632 ENOG4105G7B Protein of unknown function (DUF2992) AS53_633 ENOG4105E09 nadh pyrophosphatase AS53_635 ENOG4105C7S Dehydrogenase AS53_636 ENOG4105CPP Dehydrogenase, E1 component AS53_640 ENOG4107RDP Dehydrogenase AS53_642 ENOG4108JUB Transcriptional regulator AS53_644 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AS53_647 ENOG4107QQR Sporulation AS53_648 ENOG4105S1Z Stage IV sporulation protein B AS53_649 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AS53_651 ENOG4105DX0 Hemolysin A AS53_653 ENOG4105CTB Polyprenyl synthetase AS53_658 ENOG4108ZSR alkaline shock protein AS53_659 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AS53_664 ENOG410644B Stage III sporulation protein af AS53_666 ENOG4105KQ4 Stage iii sporulation protein ad AS53_667 ENOG4108CQH stage III sporulation protein AC AS53_668 ENOG4105KR5 Stage iii sporulation protein AS53_669 ENOG4105CD2 stage iii sporulation protein aa AS53_674 ENOG4105DC7 peptidase M24 AS53_677 ENOG4105CBJ Metal-dependent enzyme AS53_678 ENOG4107YBY Hydrolase AS53_683 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AS53_684 ENOG4105WZW rhodanese family AS53_688 ENOG41080TC multidrug resistance protein AS53_695 ENOG4105CJ1 ABC, transporter AS53_696 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AS53_7 ENOG41067MG lrgb family AS53_702 ENOG4105C0D helicase AS53_726 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AS53_727 ENOG4105C3R Methionine synthase AS53_729 ENOG4105C28 cystathionine AS53_730 ENOG4105C28 cystathionine AS53_734 ENOG4105C5X domain protein AS53_736 ENOG4105DKQ ROK family AS53_738 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AS53_741 ENOG4108UTW Plays a role in the regulation of phosphate uptake AS53_742 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AS53_743 ENOG4105E2Z phosphate ABC transporter (Permease AS53_744 ENOG4105C8U phosphate abc transporter AS53_745 ENOG4105PWN phosphate abc transporter AS53_746 ENOG4107RF6 penicillin-binding protein AS53_748 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AS53_753 ENOG4105N80 Ferric uptake regulator, Fur family AS53_755 ENOG4105FDK ABC transporter AS53_756 ENOG4108JYZ YitT family AS53_757 ENOG41069ZM Protein of unknown function (DUF2624) AS53_762 ENOG4105EGD dinuclear metal center protein, YbgI family AS53_765 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_766 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AS53_771 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AS53_772 ENOG4105KG3 cytidine deaminase AS53_773 ENOG4107YR5 Diacylglycerol kinase AS53_775 ENOG4105CTJ Metal Dependent Phosphohydrolase AS53_776 ENOG4105C9A Phoh family AS53_778 ENOG41068P3 sporulation protein YqfC AS53_779 ENOG4105KTH gatB Yqey AS53_781 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AS53_782 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AS53_786 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AS53_788 ENOG4105CSA Coproporphyrinogen iii oxidase AS53_789 ENOG4105KVH Transcriptional regulator AS53_794 ENOG4105TQK DNA polymerase iii, delta' subunit AS53_796 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AS53_797 ENOG4108UK2 deaminase AS53_798 ENOG4105KQC Competence protein AS53_800 ENOG4105DXX methyltransferase AS53_802 ENOG4108WF2 Metal Dependent Phosphohydrolase AS53_804 ENOG410812S Rna-binding protein AS53_806 ENOG4105CQW ribosome biogenesis GTPase YqeH AS53_807 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AS53_809 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_814 ENOG4108TVJ Nitroreductase AS53_817 ENOG4105G6Z alkaline phosphatase AS53_819 ENOG4108MUZ hydrolase AS53_82 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) AS53_826 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AS53_827 ENOG4105MIR Phenylalanine 4-monooxygenase AS53_829 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AS53_830 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AS53_838 ENOG4105S6R Iron-hydroxamate transporter permease subunit AS53_839 ENOG4108V5C ABC transporter AS53_841 ENOG4108EKI Dehydrogenase AS53_842 ENOG4105C28 cystathionine AS53_848 ENOG4107XRG penicillin-binding protein AS53_851 ENOG4105CFP Peptidase U32 AS53_852 ENOG4105XYU peptidase (U32 family) AS53_853 ENOG4108VQJ O-methyltransferase AS53_854 ENOG4105HHA aminodeoxychorismate lyase AS53_858 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AS53_860 ENOG4105C02 permease AS53_863 ENOG41060CR AS53_864 ENOG4105C7H Helicase, RecD TraA family AS53_866 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AS53_867 ENOG4105C3J Cysteine desulfurase AS53_869 ENOG4105D1H recombination factor protein RarA AS53_870 ENOG4108VCI transcription factor, rsfa family AS53_871 ENOG4105CUZ uba thif-type nad fad binding protein AS53_873 ENOG4105CUT histidyl-tRNA synthetase AS53_876 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AS53_878 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AS53_879 ENOG41076HS cation diffusion facilitator family transporter AS53_880 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AS53_882 ENOG4105CKP Polysaccharide Biosynthesis Protein AS53_883 ENOG4108QG2 Membrane AS53_885 ENOG4105VIE preprotein translocase, subunit YajC AS53_888 ENOG41061AI Protein of unknown function (DUF2905) AS53_891 ENOG4108HUF Transporter AS53_893 ENOG4108IPJ Membrane AS53_894 ENOG4108IPJ Membrane AS53_895 ENOG41082BM Transcriptional regulator, arsr family AS53_900 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AS53_901 ENOG4108IYU L-aspartate oxidase AS53_904 ENOG4108RPX mosc domain containing protein AS53_905 ENOG4105CQC Prephenate dehydratase AS53_909 ENOG4105EWM Histidine kinase AS53_912 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AS53_915 ENOG4105X36 (ribosomal) protein AS53_917 ENOG4105C03 ribonuclease AS53_920 ENOG4107QMS site-determining protein AS53_923 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AS53_924 ENOG4105DFF Rod shape-determining protein mreb AS53_928 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AS53_929 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AS53_931 ENOG41068KH stage VI sporulation protein D AS53_933 ENOG4105D52 delta-aminolevulinic acid dehydratase AS53_938 ENOG4105K56 Transcriptional regulator AS53_942 ENOG4108IUQ atp-dependent protease AS53_948 ENOG4108QCI YvbH-like oligomerisation region AS53_952 ENOG4105M59 Phosphodiesterase, mj0936 family AS53_953 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AS53_955 ENOG4108XJQ germination protein AS53_957 ENOG4108PCX Major Facilitator AS53_959 ENOG4105KBX Transcriptional regulator, TetR family AS53_962 ENOG4105PFC Transcriptional regulator AS53_965 ENOG4105DZC cytosine deaminase AS53_966 ENOG4105DZC cytosine deaminase AS53_967 ENOG4105DEF Extracellular solute-binding protein, family 5 AS53_968 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS53_971 ENOG4108JQ7 (ABC) transporter AS53_972 ENOG4108HRK Histidine kinase AS53_973 ENOG4105DY9 regulatoR AS53_976 ENOG41067S9 phage shock protein C, PspC AS53_977 ENOG4108JCI Transcriptional regulator AS53_979 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AS53_980 ENOG4108Z40 Transcriptional regulator AS53_981 ENOG4105RHA ABC transporter, permease AS53_982 ENOG4108IUX (ABC) transporter AS53_983 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AS53_984 ENOG4105ER2 Ompa motb domain protein AS53_985 ENOG4105ER2 Ompa motb domain protein AS53_986 ENOG4105E14 MotA TolQ exbB proton channel AS53_987 ENOG4108VXD carboxy-peptidase AS53_989 ENOG4105E33 succinate dehydrogenase AS53_991 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AS53_994 ENOG4105K63 Thioredoxin AS53_995 ENOG4105C10 Electron transfer flavoprotein AS53_996 ENOG4105BZJ Electron transfer flavoprotein AS53_997 ENOG41060WC Enoyl-CoA hydratase AS53_998 ENOG4107Z3H Transcriptional regulator, TetR family AS53_999 ENOG4105CEY Amp-dependent synthetase and ligase