locus-tag	class	description
AS53_10	COG0730	response to heat
AS53_1003	COG2318	DinB family
AS53_1009	COG1131	(ABC) transporter
AS53_1010	COG2205	protein histidine kinase activity
AS53_1011	COG0745	RESPONSE REGULATOR receiver
AS53_1013	COG4895	conserved protein (DUF2196)
AS53_1014	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AS53_1017	COG4509	Sortase family
AS53_1018	COG1120	ATPase activity
AS53_1022	COG5386	Cell surface protein
AS53_1024	COG5386	Cell surface protein
AS53_1025	COG1114	Component of the transport system for branched-chain amino acids
AS53_1026	COG1187	pseudouridine synthase activity
AS53_1029	COG1796	DNA polymerase
AS53_1029	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AS53_103	COG0174	glutamine synthetase
AS53_1030	COG1286	toxin biosynthetic process
AS53_1036	COG0017	Asparaginyl-tRNA synthetase
AS53_1037	COG0072	phenylalanine-tRNA ligase activity
AS53_1037	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS53_1039	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS53_104	COG0789	Transcriptional regulator
AS53_1041	COG1418	mRNA catabolic process
AS53_1046	COG2814	Major facilitator Superfamily
AS53_1047	COG1566	PFAM secretion protein HlyD family protein
AS53_1048	COG1309	transcriptional regulator
AS53_1049	COG1363	Peptidase, m42
AS53_105	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AS53_1053	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AS53_1054	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AS53_1056	COG1484	DNA-dependent DNA replication
AS53_1057	COG3611	Membrane attachment protein
AS53_1058	COG3611	Membrane attachment protein
AS53_106	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AS53_1060	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AS53_1061	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AS53_1062	COG0237	dephospho-CoA kinase activity
AS53_1063	COG1971	Probably functions as a manganese efflux pump
AS53_1064	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AS53_1065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS53_1065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS53_1066	COG5002	protein histidine kinase activity
AS53_1067	COG0745	RESPONSE REGULATOR receiver
AS53_107	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AS53_1071	COG0538	isocitrate dehydrogenase activity
AS53_1072	COG0372	Belongs to the citrate synthase family
AS53_1074	COG0628	permease
AS53_1075	COG3030	protein affecting phage T7 exclusion by the F plasmid
AS53_108	COG2860	membrane
AS53_1080	COG1725	Transcriptional regulator
AS53_1081	COG0281	malic enzyme
AS53_1082	COG0587	DNA-directed DNA polymerase activity
AS53_1085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AS53_1089	COG4109	DRTGG domain
AS53_109	COG0464	growth
AS53_1092	COG0006	proline dipeptidase activity
AS53_1099	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_1100	COG0662	Cupin 2, conserved barrel domain protein
AS53_1102	COG1476	TRANSCRIPTIONal
AS53_1105	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_1106	COG0589	response to stress
AS53_1115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_1119	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AS53_1120	COG0827	DNA restriction-modification system
AS53_1121	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AS53_1122	COG3874	Sporulation protein YtfJ
AS53_1124	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AS53_1125	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AS53_1127	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS53_1130	COG1104	cysteine desulfurase activity
AS53_1132	COG0583	DNA-binding transcription factor activity
AS53_1133	COG0697	spore germination
AS53_1134	COG1309	transcriptional regulator
AS53_1135	COG1309	transcriptional regulator
AS53_1136	COG1956	GAF domain-containing protein
AS53_1137	COG0626	cystathionine gamma-synthase activity
AS53_1141	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AS53_1143	COG1595	DNA-templated transcription, initiation
AS53_1145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS53_1146	COG0454	-acetyltransferase
AS53_1147	COG0517	IMP dehydrogenase activity
AS53_1148	COG0123	including yeast histone deacetylase and acetoin utilization protein
AS53_1150	COG0745	RESPONSE REGULATOR receiver
AS53_1152	COG0666	response to abiotic stimulus
AS53_1159	COG1609	Transcriptional regulator
AS53_116	COG3584	3D domain protein
AS53_116	COG1388	LysM domain
AS53_1160	COG4851	CamS sex pheromone cAM373 precursor
AS53_1161	COG3118	belongs to the thioredoxin family
AS53_1163	COG2309	aminopeptidase activity
AS53_1167	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_117	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS53_117	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS53_117	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS53_1170	COG1674	ftsk spoiiie
AS53_1172	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS53_1173	COG4848	Belongs to the UPF0354 family
AS53_1174	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS53_1175	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AS53_1176	COG1363	Peptidase, m42
AS53_1178	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_118	COG1105	Belongs to the carbohydrate kinase PfkB family
AS53_1181	COG0510	thiamine kinase activity
AS53_1182	COG1523	belongs to the glycosyl hydrolase 13 family
AS53_1184	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS53_1185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS53_1186	COG1349	DNA-binding transcription factor activity
AS53_1187	COG1187	pseudouridine synthase activity
AS53_1188	COG2244	polysaccharide biosynthetic process
AS53_1189	COG2081	HI0933 family
AS53_119	COG1349	DNA-binding transcription factor activity
AS53_1190	COG2814	Major facilitator Superfamily
AS53_1192	COG3832	glyoxalase III activity
AS53_1196	COG1329	Transcriptional regulator
AS53_1198	COG4975	Glucose uptake
AS53_12	COG3409	Peptidoglycan-binding domain 1 protein
AS53_12	COG5632	N-Acetylmuramoyl-L-alanine amidase
AS53_120	COG1979	alcohol dehydrogenase
AS53_1201	COG0314	molybdopterin synthase activity
AS53_1202	COG1763	Mo-molybdopterin cofactor biosynthetic process
AS53_1203	COG0303	'Molybdopterin
AS53_1205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS53_1206	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AS53_121	COG1979	alcohol dehydrogenase
AS53_1210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS53_1212	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AS53_122	COG2322	membrane
AS53_1220	COG2814	Major facilitator Superfamily
AS53_1221	COG0475	glutathione-regulated potassium exporter activity
AS53_1222	COG0490	domain, Protein
AS53_1223	COG0582	viral genome integration into host DNA
AS53_1225	COG1136	(ABC) transporter
AS53_1229	COG1242	4 iron, 4 sulfur cluster binding
AS53_1230	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AS53_1231	COG1131	(ABC) transporter
AS53_1233	COG1794	racemase activity, acting on amino acids and derivatives
AS53_1237	COG2267	carboxylic ester hydrolase activity
AS53_1238	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AS53_1239	COG0671	phosphoesterase, PA-phosphatase related
AS53_1240	COG0438	transferase activity, transferring glycosyl groups
AS53_1242	COG0521	Mo-molybdopterin cofactor biosynthetic process
AS53_125	COG1113	amino acid transport
AS53_1252	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AS53_1253	COG5002	protein histidine kinase activity
AS53_1254	COG4191	Histidine kinase
AS53_1255	COG2267	carboxylic ester hydrolase activity
AS53_1256	COG1368	sulfuric ester hydrolase activity
AS53_1260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS53_1261	COG1116	anion transmembrane transporter activity
AS53_1262	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS53_1266	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AS53_1268	COG0494	nUDIX hydrolase
AS53_1273	COG0288	reversible hydration of carbon dioxide
AS53_1275	COG1271	oxidase subunit
AS53_1276	COG1294	oxidase, subunit
AS53_128	COG1408	metallophosphoesterase
AS53_1280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_1285	COG1842	Phage shock protein A
AS53_129	COG2116	formate transmembrane transporter activity
AS53_1292	COG5002	protein histidine kinase activity
AS53_1293	COG0745	RESPONSE REGULATOR receiver
AS53_1299	COG1597	lipid kinase activity
AS53_1306	COG0586	Pfam SNARE associated Golgi protein
AS53_1308	COG0577	efflux transmembrane transporter activity
AS53_1309	COG1136	(ABC) transporter
AS53_131	COG2217	Heavy metal translocating P-type atpase
AS53_1310	COG3708	Transcriptional regulator
AS53_1310	COG2207	Transcriptional regulator
AS53_1311	COG0745	RESPONSE REGULATOR receiver
AS53_1312	COG2205	protein histidine kinase activity
AS53_1313	COG0577	efflux transmembrane transporter activity
AS53_1315	COG0577	efflux transmembrane transporter activity
AS53_1316	COG0577	efflux transmembrane transporter activity
AS53_1317	COG1136	(ABC) transporter
AS53_1318	COG0577	efflux transmembrane transporter activity
AS53_1319	COG0577	efflux transmembrane transporter activity
AS53_132	COG2608	mercury ion transmembrane transporter activity
AS53_1326	COG3964	amidohydrolase
AS53_133	COG1937	Protein conserved in bacteria
AS53_1332	COG4948	Mandelate Racemase Muconate Lactonizing
AS53_1334	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AS53_1335	COG0596	Alpha beta hydrolase
AS53_1336	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AS53_1337	COG1169	isochorismate synthase
AS53_1338	COG1575	Belongs to the MenA family. Type 1 subfamily
AS53_1339	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AS53_1340	COG1278	Cold shock
AS53_1344	COG0058	SHG alpha-glucan phosphorylase activity
AS53_1345	COG0297	glycogen (starch) synthase activity
AS53_1346	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AS53_1347	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AS53_1349	COG0039	L-malate dehydrogenase activity
AS53_135	COG2819	hydrolase of the alpha beta superfamily
AS53_136	COG1120	ATPase activity
AS53_1368	COG0544	peptidyl-prolyl cis-trans isomerase activity
AS53_137	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_138	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_1384	COG0544	peptidyl-prolyl cis-trans isomerase activity
AS53_139	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_1392	COG1285	pathogenesis
AS53_1394	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AS53_1395	COG0166	Belongs to the GPI family
AS53_1396	COG2155	Conserved Protein
AS53_1397	COG1098	S1 RNA binding domain
AS53_1398	COG0436	Aminotransferase
AS53_1399	COG1522	sequence-specific DNA binding
AS53_1400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS53_1401	COG2267	carboxylic ester hydrolase activity
AS53_1403	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AS53_1407	COG5018	Exonuclease
AS53_1408	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AS53_141	COG0708	Exodeoxyribonuclease III
AS53_1411	COG0423	glycine-tRNA ligase activity
AS53_1412	COG2050	protein possibly involved in aromatic compounds catabolism
AS53_1414	COG1268	BioY protein
AS53_1416	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS53_1417	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS53_142	COG2169	Transcriptional regulator
AS53_1420	COG3584	3D domain protein
AS53_1423	COG1252	NADH dehydrogenase
AS53_1426	COG3708	Transcriptional regulator
AS53_1429	COG1683	Conserved Protein
AS53_143	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AS53_1432	COG0316	Belongs to the HesB IscA family
AS53_1435	COG1252	NADH dehydrogenase
AS53_1437	COG0390	transport system, permease component
AS53_1438	COG2824	Alkylphosphonate utilization operon protein PhnA
AS53_144	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AS53_1446	COG4837	Protein of unknown function (DUF1462)
AS53_1447	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AS53_1449	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AS53_1450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AS53_1452	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS53_1453	COG0647	UMP catabolic process
AS53_1455	COG2445	Protein of unknown function DUF86
AS53_1456	COG1494	fructose-1,6-bisphosphatase
AS53_1459	COG4470	Protein conserved in bacteria
AS53_146	COG2364	Membrane
AS53_1461	COG0789	Transcriptional regulator
AS53_1462	COG4377	Putative membrane peptidase family (DUF2324)
AS53_1467	COG0739	heme binding
AS53_1469	COG3377	Domain of unknown function (DUF1805)
AS53_1470	COG0737	Belongs to the 5'-nucleotidase family
AS53_1471	COG1695	Transcriptional regulator
AS53_1473	COG0719	Fe-S assembly protein
AS53_1474	COG0822	iron-sulfur transferase activity
AS53_1475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AS53_1476	COG0719	Fe-S assembly protein
AS53_1477	COG0396	ATPase activity
AS53_1478	COG1464	Belongs to the NlpA lipoprotein family
AS53_1479	COG1464	Belongs to the NlpA lipoprotein family
AS53_1480	COG2011	ABC-type metal ion transport system permease component
AS53_1481	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS53_1483	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS53_1484	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AS53_1486	COG1393	Belongs to the ArsC family
AS53_149	COG2267	carboxylic ester hydrolase activity
AS53_1495	COG0039	L-malate dehydrogenase activity
AS53_15	COG1132	(ABC) transporter
AS53_150	COG0346	lactoylglutathione lyase activity
AS53_1500	COG1309	transcriptional regulator
AS53_1501	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_1502	COG1960	acyl-CoA dehydrogenase activity
AS53_1503	COG0183	Belongs to the thiolase family
AS53_1504	COG1024	Enoyl-CoA hydratase
AS53_1504	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS53_1506	COG1686	Belongs to the peptidase S11 family
AS53_1509	COG0011	TIGRFAM Protein of
AS53_151	COG3300	MHYT domain
AS53_151	COG5001	Diguanylate cyclase
AS53_1510	COG0840	transmembrane signaling receptor activity
AS53_1514	COG2814	Major facilitator Superfamily
AS53_1515	COG0531	amino acid
AS53_1517	COG0706	membrane insertase activity
AS53_1519	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_1526	COG0586	Pfam SNARE associated Golgi protein
AS53_1528	COG1376	ErfK ybiS ycfS ynhG family protein
AS53_1529	COG0745	RESPONSE REGULATOR receiver
AS53_1530	COG5002	protein histidine kinase activity
AS53_1533	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS53_1536	COG2151	metal-sulfur cluster biosynthetic enzyme
AS53_1537	COG3227	Zinc metalloprotease (Elastase)
AS53_1538	COG1741	Belongs to the pirin family
AS53_154	COG1346	cytolysis
AS53_1541	COG0475	glutathione-regulated potassium exporter activity
AS53_1542	COG0490	domain, Protein
AS53_1543	COG1115	amino acid carrier protein
AS53_1544	COG0783	Belongs to the Dps family
AS53_1547	COG1611	Belongs to the LOG family
AS53_155	COG1380	Effector of murein hydrolase LrgA
AS53_1550	COG2311	Membrane
AS53_1552	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS53_1553	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS53_1554	COG1115	amino acid carrier protein
AS53_1555	COG1115	amino acid carrier protein
AS53_1556	COG2910	NAD(P)H-binding
AS53_156	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_1561	COG0656	L-ascorbic acid biosynthetic process
AS53_1562	COG2814	Major facilitator Superfamily
AS53_1563	COG1733	regulation of RNA biosynthetic process
AS53_1565	COG1252	NADH dehydrogenase
AS53_1566	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AS53_1567	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AS53_1569	COG0840	transmembrane signaling receptor activity
AS53_1569	COG3290	protein histidine kinase activity
AS53_157	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS53_157	COG0596	Alpha beta hydrolase
AS53_1571	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS53_1572	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS53_1575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_1576	COG3223	Belongs to the PsiE family
AS53_158	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS53_1585	COG0557	exoribonuclease II activity
AS53_1586	COG1647	Serine aminopeptidase, S33
AS53_1587	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS53_1588	COG1346	cytolysis
AS53_16	COG1132	(ABC) transporter
AS53_1608	COG4695	Portal protein
AS53_161	COG1404	Belongs to the peptidase S8 family
AS53_1613	COG4974	Belongs to the 'phage' integrase family
AS53_1615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AS53_1616	COG0149	triose-phosphate isomerase activity
AS53_1618	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AS53_162	COG3773	Cell wall hydrolase
AS53_1621	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AS53_1626	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS53_1629	COG2323	membrane
AS53_163	COG0562	UDP-galactopyranose mutase
AS53_1630	COG0740	serine-type endopeptidase activity
AS53_1631	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS53_1633	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AS53_1635	COG1051	belongs to the nudix hydrolase family
AS53_1637	COG0492	ferredoxin-NADP+ reductase activity
AS53_1638	COG0457	Tetratricopeptide repeat
AS53_1639	COG0110	maltose O-acetyltransferase activity
AS53_164	COG1368	sulfuric ester hydrolase activity
AS53_1643	COG1950	PFAM Membrane protein of
AS53_1645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AS53_1646	COG0556	nucleotide-excision repair
AS53_1650	COG0789	Transcriptional regulator
AS53_1654	COG2855	membrane
AS53_1655	COG0583	DNA-binding transcription factor activity
AS53_1657	COG0655	NAD(P)H dehydrogenase (quinone) activity
AS53_1660	COG1132	(ABC) transporter
AS53_1661	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS53_1662	COG3409	Peptidoglycan-binding domain 1 protein
AS53_1662	COG0793	Belongs to the peptidase S41A family
AS53_1663	COG2177	Part of the ABC transporter FtsEX involved in
AS53_1664	COG2884	Cell division ATP-binding protein ftsE
AS53_1666	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AS53_1667	COG0653	protein targeting
AS53_1668	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AS53_1669	COG1278	Cold shock
AS53_1670	COG1040	competence protein
AS53_1671	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AS53_1672	COG0791	NLP P60 protein
AS53_1672	COG1388	LysM domain
AS53_1673	COG1733	regulation of RNA biosynthetic process
AS53_1674	COG1307	EDD domain protein, DegV family
AS53_1675	COG1739	Uncharacterized protein family UPF0029
AS53_1676	COG1316	TRANSCRIPTIONal
AS53_1677	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AS53_1678	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AS53_1679	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AS53_168	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AS53_1681	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AS53_1681	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AS53_1684	COG3394	polysaccharide catabolic process
AS53_1685	COG1486	melibiose metabolic process
AS53_1686	COG1447	Phosphotransferase system cellobiose-specific component IIA
AS53_1687	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AS53_1689	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AS53_1690	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AS53_1691	COG1447	Phosphotransferase system cellobiose-specific component IIA
AS53_1693	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AS53_1694	COG1301	dicarboxylic acid transport
AS53_1696	COG0346	lactoylglutathione lyase activity
AS53_1697	COG1511	domain protein
AS53_1698	COG0583	DNA-binding transcription factor activity
AS53_1699	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AS53_1702	COG1271	oxidase subunit
AS53_1703	COG1294	oxidase, subunit
AS53_1704	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AS53_1706	COG1620	l-lactate permease
AS53_1708	COG2389	metal-binding protein
AS53_1710	COG1368	sulfuric ester hydrolase activity
AS53_1713	COG0791	NLP P60 protein
AS53_1713	COG1388	LysM domain
AS53_1714	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS53_1716	COG1215	transferase activity, transferring glycosyl groups
AS53_1718	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS53_1719	COG1388	LysM domain
AS53_1719	COG3584	3D domain protein
AS53_1724	COG4715	Zinc finger, swim domain protein
AS53_1725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS53_1731	COG1191	sigma factor activity
AS53_1733	COG0577	efflux transmembrane transporter activity
AS53_1734	COG1136	(ABC) transporter
AS53_1741	COG5002	protein histidine kinase activity
AS53_1742	COG0745	RESPONSE REGULATOR receiver
AS53_1743	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AS53_1746	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AS53_1749	COG1682	transport, permease protein
AS53_1750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AS53_1758	COG1609	Transcriptional regulator
AS53_1760	COG0739	heme binding
AS53_1763	COG3279	Response regulator of the LytR AlgR family
AS53_1764	COG4555	ABC transporter
AS53_1765	COG2385	sporulation resulting in formation of a cellular spore
AS53_1766	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AS53_1768	COG4836	Membrane
AS53_1769	COG1007	ATP synthesis coupled electron transport
AS53_177	COG4550	Control of competence regulator ComK, YlbF/YmcA
AS53_1770	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS53_1771	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AS53_1773	COG0839	Belongs to the complex I subunit 6 family
AS53_1776	COG0649	NAD binding
AS53_1777	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS53_1779	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS53_178	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AS53_1780	COG3300	MHYT domain
AS53_1780	COG5001	Diguanylate cyclase
AS53_179	COG1013	pyruvate-flavodoxin oxidoreductase activity
AS53_1790	COG0356	it plays a direct role in the translocation of protons across the membrane
AS53_1796	COG0698	ribose 5-phosphate isomerase
AS53_1798	COG2190	(PTS) system
AS53_1799	COG2259	Doxx family
AS53_180	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AS53_180	COG0674	pyruvate-flavodoxin oxidoreductase activity
AS53_1800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS53_1803	COG0009	L-threonylcarbamoyladenylate synthase
AS53_1806	COG2890	protein-(glutamine-N5) methyltransferase activity
AS53_1807	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AS53_1810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AS53_1811	COG1494	fructose-1,6-bisphosphatase
AS53_1812	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AS53_1815	COG4821	SIS domain
AS53_1817	COG3343	RNA polymerase activity
AS53_1819	COG1960	acyl-CoA dehydrogenase activity
AS53_182	COG2359	stage V sporulation protein S
AS53_1820	COG1960	acyl-CoA dehydrogenase activity
AS53_1821	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS53_1822	COG0183	Belongs to the thiolase family
AS53_1823	COG2181	nitrate reductase activity
AS53_1823	COG0247	lactate metabolic process
AS53_1824	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS53_1826	COG5001	Diguanylate cyclase
AS53_1826	COG3300	MHYT domain
AS53_183	COG1692	metallophosphoesterase
AS53_1830	COG2197	response regulator
AS53_1831	COG4585	Histidine kinase
AS53_1832	COG0842	Transport permease protein
AS53_1833	COG1131	(ABC) transporter
AS53_1834	COG0024	Methionine aminopeptidase
AS53_1838	COG2234	aminopeptidase activity
AS53_1842	COG1595	DNA-templated transcription, initiation
AS53_1843	COG0018	arginyl-trna synthetase
AS53_1844	COG4506	Protein conserved in bacteria
AS53_1845	COG1619	proteins homologs of microcin C7 resistance protein MccF
AS53_1848	COG0010	Belongs to the arginase family
AS53_1849	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AS53_1850	COG2814	Major facilitator Superfamily
AS53_1851	COG0789	Transcriptional regulator
AS53_1852	COG0584	glycerophosphoryl diester phosphodiesterase
AS53_1853	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS53_1855	COG1994	Peptidase M50
AS53_1857	COG1078	dGTPase activity
AS53_1858	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_1859	COG1120	ATPase activity
AS53_1860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_1861	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_1862	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_1866	COG0095	Lipoate-protein ligase
AS53_1867	COG0280	phosphate acetyltransferase
AS53_1870	COG3773	Cell wall hydrolase
AS53_1872	COG2363	Small membrane protein
AS53_1874	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AS53_1875	COG2233	PERMEase
AS53_1876	COG0561	phosphatase activity
AS53_1877	COG2814	Major facilitator Superfamily
AS53_1879	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AS53_188	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AS53_1880	COG1131	(ABC) transporter
AS53_1881	COG2755	lipolytic protein G-D-S-L family
AS53_1882	COG1609	Transcriptional regulator
AS53_1884	COG0460	homoserine dehydrogenase
AS53_1888	COG1011	Hydrolase
AS53_1889	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS53_189	COG1426	Protein conserved in bacteria
AS53_1891	COG2197	response regulator
AS53_1892	COG4585	Histidine kinase
AS53_1892	COG2203	Gaf domain
AS53_1893	COG4585	Histidine kinase
AS53_1893	COG2203	Gaf domain
AS53_1894	COG0351	phosphomethylpyrimidine kinase
AS53_1895	COG3706	GGDEF domain
AS53_1896	COG2879	small protein
AS53_1897	COG1966	Carbon starvation protein
AS53_1898	COG3279	Response regulator of the LytR AlgR family
AS53_1899	COG0477	Major facilitator Superfamily
AS53_1904	COG0840	transmembrane signaling receptor activity
AS53_1907	COG1607	acyl-coa hydrolase
AS53_1910	COG0488	(ABC) transporter
AS53_1915	COG0463	Glycosyl transferase, family 2
AS53_1916	COG1309	transcriptional regulator
AS53_1917	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS53_1918	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS53_1918	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS53_1919	COG0628	permease
AS53_192	COG0300	oxidoreductase activity
AS53_1922	COG3279	Response regulator of the LytR AlgR family
AS53_1923	COG3275	phosphorelay sensor kinase activity
AS53_1924	COG2814	Major facilitator Superfamily
AS53_1925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS53_1926	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AS53_1927	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AS53_193	COG0612	Peptidase, M16
AS53_1931	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AS53_1932	COG1272	protein, Hemolysin III
AS53_1936	COG0516	GMP reductase activity
AS53_194	COG0612	Peptidase, M16
AS53_1942	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS53_1943	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AS53_1944	COG4853	Protein conserved in bacteria
AS53_1945	COG4863	YycH protein
AS53_1946	COG5002	protein histidine kinase activity
AS53_1947	COG0745	RESPONSE REGULATOR receiver
AS53_1953	COG0305	Participates in initiation and elongation during chromosome replication
AS53_1955	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AS53_1956	COG4241	membrane
AS53_1958	COG0629	single-stranded DNA binding
AS53_1960	COG0012	GTP binding
AS53_1961	COG4481	Protein conserved in bacteria
AS53_1962	COG0668	transmembrane transport
AS53_1964	COG1475	DNA binding
AS53_1965	COG1192	Involved in chromosome partitioning
AS53_1969	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AS53_1970	COG1847	R3H domain protein
AS53_1971	COG0706	membrane insertase activity
AS53_1975	COG0592	DNA-directed DNA polymerase activity
AS53_1976	COG2501	S4 domain
AS53_1978	COG0187	DNA topoisomerase II activity
AS53_1979	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AS53_1985	COG0517	IMP dehydrogenase activity
AS53_1985	COG0516	GMP reductase activity
AS53_1986	COG1686	Belongs to the peptidase S11 family
AS53_1992	COG1428	Deoxynucleoside kinase
AS53_1993	COG1428	Deoxynucleoside kinase
AS53_1994	COG1335	isochorismatase
AS53_1995	COG0590	tRNA wobble adenosine to inosine editing
AS53_1996	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AS53_2	COG4846	Membrane protein involved in cytochrome C biogenesis
AS53_200	COG2188	Transcriptional regulator
AS53_2008	COG1982	Orn Lys Arg decarboxylase major
AS53_201	COG1674	ftsk spoiiie
AS53_2010	COG0470	DNA polymerase III
AS53_2011	COG1774	PSP1 C-terminal conserved region
AS53_2013	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AS53_2014	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AS53_2015	COG2002	toxin-antitoxin pair type II binding
AS53_2016	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS53_2016	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS53_2018	COG0084	hydrolase, TatD family'
AS53_2019	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AS53_2022	COG4466	Protein conserved in bacteria
AS53_2025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AS53_2026	COG0251	oxidation-reduction process
AS53_2029	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AS53_203	COG0740	serine-type endopeptidase activity
AS53_2030	COG0193	aminoacyl-tRNA hydrolase activity
AS53_2032	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AS53_2033	COG2002	toxin-antitoxin pair type II binding
AS53_2034	COG2244	polysaccharide biosynthetic process
AS53_2035	COG3956	TIGRFAM MazG family protein
AS53_2036	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AS53_204	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS53_2040	COG1098	S1 RNA binding domain
AS53_2043	COG2208	phosphoserine phosphatase activity
AS53_2045	COG0037	tRNA processing
AS53_2047	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AS53_2050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS53_2051	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AS53_2052	COG0512	Glutamine amidotransferase of anthranilate synthase
AS53_2053	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS53_2054	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AS53_2055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AS53_2056	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AS53_2057	COG1396	sequence-specific DNA binding
AS53_2058	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AS53_206	COG0527	aspartate kinase activity
AS53_2064	COG3880	PFAM UvrB UvrC protein
AS53_2066	COG0542	response to heat
AS53_2067	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AS53_2069	COG4956	integral membrane protein (PIN domain superfamily)
AS53_207	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AS53_2073	COG1045	serine acetyltransferase
AS53_2076	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS53_2077	COG3688	RNA-binding protein containing a PIN domain
AS53_2079	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS53_208	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AS53_2080	COG0250	Participates in transcription elongation, termination and antitermination
AS53_2085	COG2813	Specifically methylates the guanine in position
AS53_2087	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AS53_2088	COG1358	cellular component organization or biogenesis
AS53_209	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS53_210	COG1873	PFAM PRC-barrel domain
AS53_211	COG0612	Peptidase, M16
AS53_2110	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AS53_2115	COG0201	protein transport
AS53_2117	COG0024	Methionine aminopeptidase
AS53_2119	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AS53_212	COG0726	polysaccharide deacetylase
AS53_2125	COG1122	ATPase activity
AS53_2126	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AS53_2127	COG0101	tRNA pseudouridine synthase activity
AS53_2131	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS53_2132	COG0489	protein tyrosine kinase activity
AS53_2134	COG2194	sulfuric ester hydrolase activity
AS53_2135	COG0726	polysaccharide deacetylase
AS53_215	COG0196	riboflavin kinase activity
AS53_2153	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AS53_2154	COG4856	YbbR-like protein
AS53_2156	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AS53_2157	COG0596	Alpha beta hydrolase
AS53_216	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AS53_2162	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AS53_2163	COG1506	peptidase
AS53_2163	COG4946	Tricorn protease homolog
AS53_2163	COG0823	Involved in the tonB-independent uptake of proteins
AS53_2171	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_2172	COG2011	ABC-type metal ion transport system permease component
AS53_2173	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS53_2174	COG1464	Belongs to the NlpA lipoprotein family
AS53_2177	COG0277	FAD linked oxidase domain protein
AS53_2178	COG2271	Major facilitator Superfamily
AS53_218	COG1550	Protein conserved in bacteria
AS53_2180	COG2814	Major facilitator Superfamily
AS53_2183	COG0601	transmembrane transport
AS53_2184	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS53_2185	COG0444	Belongs to the ABC transporter superfamily
AS53_2186	COG4608	Belongs to the ABC transporter superfamily
AS53_2187	COG4166	transmembrane transport
AS53_2189	COG2207	Transcriptional regulator
AS53_2192	COG4166	transmembrane transport
AS53_2193	COG4166	transmembrane transport
AS53_2194	COG0656	L-ascorbic acid biosynthetic process
AS53_2195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS53_2198	COG4149	molybdate abc transporter
AS53_2199	COG0725	ABC transporter, periplasmic molybdate-binding protein
AS53_22	COG3639	organic phosphonate transmembrane transporter activity
AS53_220	COG1358	cellular component organization or biogenesis
AS53_2200	COG0725	ABC transporter, periplasmic molybdate-binding protein
AS53_2201	COG1910	domain protein
AS53_2204	COG0583	DNA-binding transcription factor activity
AS53_2205	COG0697	spore germination
AS53_2208	COG0204	Acyl-transferase
AS53_221	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AS53_2210	COG1609	Transcriptional regulator
AS53_2212	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_2215	COG0084	hydrolase, TatD family'
AS53_2216	COG5298	Protein conserved in bacteria
AS53_222	COG0195	Participates in both transcription termination and antitermination
AS53_2220	COG0488	(ABC) transporter
AS53_2223	COG0747	negative chemotaxis
AS53_2224	COG0601	transmembrane transport
AS53_2226	COG0444	Belongs to the ABC transporter superfamily
AS53_2227	COG4608	Belongs to the ABC transporter superfamily
AS53_2228	COG0561	phosphatase activity
AS53_2229	COG0561	phosphatase activity
AS53_2234	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AS53_2235	COG0179	Fumarylacetoacetate (FAA) hydrolase
AS53_2237	COG2814	Major facilitator Superfamily
AS53_2240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AS53_2242	COG0457	Tetratricopeptide repeat
AS53_2242	COG0705	Rhomboid family
AS53_2243	COG4294	response to UV
AS53_2245	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AS53_2246	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AS53_2247	COG0864	Transcriptional regulator
AS53_2248	COG2337	Toxic component of a toxin-antitoxin (TA) module
AS53_2249	COG2183	response to ionizing radiation
AS53_226	COG0750	zinc metalloprotease
AS53_2268	COG0802	atpase or kinase
AS53_2269	COG1214	PFAM Peptidase M22, glycoprotease
AS53_227	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AS53_2270	COG0456	acetyltransferase
AS53_2271	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AS53_2272	COG0488	(ABC) transporter
AS53_2275	COG1266	CAAX protease self-immunity
AS53_2279	COG2252	PERMEase
AS53_228	COG4589	Belongs to the CDS family
AS53_2281	COG5002	protein histidine kinase activity
AS53_2289	COG2226	methyltransferase
AS53_229	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AS53_2295	COG1215	transferase activity, transferring glycosyl groups
AS53_23	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AS53_2300	COG1968	undecaprenyl-diphosphatase activity
AS53_2303	COG2205	protein histidine kinase activity
AS53_2304	COG0745	RESPONSE REGULATOR receiver
AS53_2309	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AS53_231	COG0528	UMP kinase activity
AS53_2310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AS53_2311	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AS53_2313	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AS53_2316	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AS53_2318	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AS53_2320	COG0151	Belongs to the GarS family
AS53_2325	COG0210	DNA helicase
AS53_2327	COG4851	CamS sex pheromone cAM373 precursor
AS53_2331	COG1335	isochorismatase
AS53_2332	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS53_2333	COG2011	ABC-type metal ion transport system permease component
AS53_2334	COG1464	Belongs to the NlpA lipoprotein family
AS53_2337	COG0003	Pfam Anion-transporting ATPase
AS53_2338	COG0003	Pfam Anion-transporting ATPase
AS53_2339	COG1846	Transcriptional regulator
AS53_2344	COG1597	lipid kinase activity
AS53_2345	COG0546	phosphoglycolate phosphatase activity
AS53_2346	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AS53_2348	COG1012	belongs to the aldehyde dehydrogenase family
AS53_2349	COG2076	Multidrug Resistance protein
AS53_2350	COG2309	aminopeptidase activity
AS53_2353	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS53_2354	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS53_2355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AS53_2357	COG4807	Protein conserved in bacteria
AS53_2363	COG1473	amidohydrolase
AS53_2366	COG0450	alkyl hydroperoxide reductase
AS53_2367	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AS53_2369	COG0235	Class ii aldolase
AS53_237	COG4974	Belongs to the 'phage' integrase family
AS53_2370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_2371	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_2372	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_2375	COG0166	Belongs to the GPI family
AS53_2381	COG5002	protein histidine kinase activity
AS53_2385	COG3541	Predicted nucleotidyltransferase
AS53_2386	COG2814	Major facilitator Superfamily
AS53_2387	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS53_2387	COG0723	plastoquinol--plastocyanin reductase activity
AS53_2389	COG0765	amino acid transport
AS53_239	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AS53_2390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS53_2392	COG0840	transmembrane signaling receptor activity
AS53_2393	COG0840	transmembrane signaling receptor activity
AS53_2394	COG0366	Alpha amylase catalytic
AS53_2395	COG2190	(PTS) system
AS53_2395	COG1263	PTS System
AS53_2395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS53_2401	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AS53_2404	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS53_2406	COG1116	anion transmembrane transporter activity
AS53_2407	COG0488	(ABC) transporter
AS53_241	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AS53_2416	COG2270	Major facilitator Superfamily
AS53_2419	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AS53_2422	COG2310	stress, protein
AS53_2423	COG2310	stress, protein
AS53_2424	COG2310	stress, protein
AS53_2425	COG0861	Integral membrane protein TerC family
AS53_2427	COG3853	Toxic anion resistance protein (TelA)
AS53_2430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AS53_2432	COG1295	ribonuclease BN
AS53_2433	COG2217	Heavy metal translocating P-type atpase
AS53_2434	COG0697	spore germination
AS53_2436	COG0681	Belongs to the peptidase S26 family
AS53_2439	COG0586	Pfam SNARE associated Golgi protein
AS53_2442	COG3871	stress protein (general stress protein 26)
AS53_2443	COG0387	Pfam Sodium calcium exchanger
AS53_2445	COG0535	radical SAM domain protein
AS53_2450	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AS53_2451	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS53_2452	COG0582	viral genome integration into host DNA
AS53_2456	COG1396	sequence-specific DNA binding
AS53_2463	COG1484	DNA-dependent DNA replication
AS53_249	COG1837	Belongs to the UPF0109 family
AS53_251	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AS53_2510	COG0101	tRNA pseudouridine synthase activity
AS53_2512	COG3829	transcription factor binding
AS53_2514	COG0833	amino acid
AS53_2515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS53_2520	COG2066	Belongs to the glutaminase family
AS53_2521	COG1263	PTS System
AS53_2521	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS53_2522	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AS53_2525	COG0463	Glycosyl transferase, family 2
AS53_2528	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AS53_2528	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS53_253	COG0552	protein localization to endoplasmic reticulum
AS53_2531	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AS53_2535	COG1228	amidohydrolase
AS53_2536	COG1090	epimerase
AS53_254	COG1196	nuclear chromosome segregation
AS53_2542	COG1988	membrane-bound metal-dependent
AS53_2543	COG1194	a g-specific adenine glycosylase
AS53_2548	COG1132	(ABC) transporter
AS53_2549	COG4129	membrane
AS53_2550	COG0067	glutamate synthase
AS53_2550	COG0069	glutamate synthase activity
AS53_2550	COG0070	glutamate synthase
AS53_2552	COG4555	ABC transporter
AS53_2556	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AS53_2557	COG0735	belongs to the Fur family
AS53_257	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_2575	COG0544	peptidyl-prolyl cis-trans isomerase activity
AS53_258	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AS53_2582	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AS53_2583	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AS53_2585	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AS53_2587	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AS53_2590	COG2766	serine protein kinase
AS53_2594	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS53_2596	COG1585	Membrane protein implicated in regulation of membrane protease activity
AS53_2597	COG2268	Band 7 protein
AS53_2599	COG3290	protein histidine kinase activity
AS53_26	COG0737	Belongs to the 5'-nucleotidase family
AS53_2600	COG4565	transcriptional regulatory protein
AS53_2601	COG2851	Citrate transporter
AS53_2605	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AS53_2606	COG3842	ATPase activity
AS53_2607	COG1175	transmembrane transport
AS53_2608	COG0395	ABC-type sugar transport system, permease component
AS53_261	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AS53_2610	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AS53_2611	COG0745	RESPONSE REGULATOR receiver
AS53_2612	COG5002	protein histidine kinase activity
AS53_2614	COG4990	cell redox homeostasis
AS53_2619	COG4565	transcriptional regulatory protein
AS53_262	COG1461	Dihydroxyacetone kinase
AS53_2620	COG3493	citrate carrier protein
AS53_2621	COG0281	malic enzyme
AS53_2624	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_2628	COG0745	RESPONSE REGULATOR receiver
AS53_263	COG1302	Protein conserved in bacteria
AS53_2630	COG0456	acetyltransferase
AS53_2630	COG0454	-acetyltransferase
AS53_2631	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AS53_2632	COG3383	formate dehydrogenase (NAD+) activity
AS53_2637	COG0531	amino acid
AS53_2638	COG0640	Transcriptional regulator
AS53_2641	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AS53_2644	COG3227	Zinc metalloprotease (Elastase)
AS53_2648	COG2720	vancomycin resistance protein
AS53_2649	COG1316	TRANSCRIPTIONal
AS53_265	COG1564	THIamine pyrophosphokinase
AS53_2650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS53_2651	COG0346	lactoylglutathione lyase activity
AS53_2652	COG1253	flavin adenine dinucleotide binding
AS53_2653	COG1027	Aspartate ammonia-lyase
AS53_2654	COG1620	l-lactate permease
AS53_2657	COG3104	oligopeptide transport
AS53_2658	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_2659	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_266	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AS53_2660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_2662	COG2226	methyltransferase
AS53_2663	COG0156	8-amino-7-oxononanoate synthase activity
AS53_2664	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS53_2666	COG4548	von Willebrand factor, type A
AS53_2667	COG0714	Associated with various cellular activities
AS53_2668	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS53_267	COG1162	GTPase activity
AS53_2672	COG0531	amino acid
AS53_2673	COG2188	Transcriptional regulator
AS53_2674	COG1263	PTS System
AS53_2674	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS53_2675	COG0366	Alpha amylase catalytic
AS53_2678	COG0697	spore germination
AS53_268	COG0515	serine threonine protein kinase
AS53_268	COG2815	serine threonine protein kinase
AS53_2680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AS53_2681	COG1115	amino acid carrier protein
AS53_2682	COG1126	abc transporter atp-binding protein
AS53_2683	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS53_2684	COG0765	amino acid transport
AS53_2685	COG0765	amino acid transport
AS53_2686	COG0833	amino acid
AS53_269	COG0631	protein serine/threonine phosphatase activity
AS53_2691	COG2378	regulation of single-species biofilm formation
AS53_2692	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AS53_2693	COG5002	protein histidine kinase activity
AS53_2696	COG0659	secondary active sulfate transmembrane transporter activity
AS53_2699	COG0747	negative chemotaxis
AS53_2701	COG0601	transmembrane transport
AS53_2702	COG4608	Belongs to the ABC transporter superfamily
AS53_2704	COG2271	Major facilitator Superfamily
AS53_2705	COG1846	Transcriptional regulator
AS53_2706	COG0477	Major facilitator Superfamily
AS53_2707	COG0477	Major facilitator Superfamily
AS53_2708	COG1609	Transcriptional regulator
AS53_2709	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS53_271	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS53_271	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AS53_2711	COG1129	ABC transporter
AS53_2712	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS53_2713	COG1879	ABC-type sugar transport system periplasmic component
AS53_2714	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AS53_2718	COG1063	alcohol dehydrogenase
AS53_2721	COG3568	Endonuclease Exonuclease Phosphatase
AS53_2726	COG1968	undecaprenyl-diphosphatase activity
AS53_2727	COG0840	transmembrane signaling receptor activity
AS53_2728	COG3584	3D domain protein
AS53_2728	COG1388	LysM domain
AS53_2729	COG1476	TRANSCRIPTIONal
AS53_273	COG0242	peptide deformylase activity
AS53_2732	COG3104	oligopeptide transport
AS53_2733	COG1114	Component of the transport system for branched-chain amino acids
AS53_2736	COG1113	amino acid transport
AS53_2737	COG2252	PERMEase
AS53_274	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AS53_2742	COG0475	glutathione-regulated potassium exporter activity
AS53_2742	COG0569	domain protein
AS53_2745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AS53_2746	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AS53_2747	COG4990	cell redox homeostasis
AS53_275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AS53_2750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS53_2751	COG0697	spore germination
AS53_2752	COG0531	amino acid
AS53_2754	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AS53_2755	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AS53_2756	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AS53_2756	COG1918	ferrous iron import across plasma membrane
AS53_2757	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AS53_2758	COG0573	inorganic phosphate transmembrane transporter activity
AS53_2759	COG0581	inorganic phosphate transmembrane transporter activity
AS53_2761	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS53_277	COG0194	GDP metabolic process
AS53_2775	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AS53_2779	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AS53_2780	COG1116	anion transmembrane transporter activity
AS53_2781	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS53_2782	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS53_2783	COG0352	thiamine-phosphate diphosphorylase activity
AS53_2784	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS53_2785	COG2104	thiamine diphosphate biosynthetic process
AS53_2787	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS53_2788	COG0351	phosphomethylpyrimidine kinase
AS53_279	COG1561	YicC-like family, N-terminal region
AS53_2795	COG2205	protein histidine kinase activity
AS53_2796	COG2814	Major facilitator Superfamily
AS53_2797	COG1846	Transcriptional regulator
AS53_28	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AS53_280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AS53_2800	COG2252	PERMEase
AS53_2801	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_2805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS53_2806	COG1621	beta-fructofuranosidase activity
AS53_2807	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS53_2807	COG1263	PTS System
AS53_2808	COG1609	Transcriptional regulator
AS53_2810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS53_2811	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AS53_2819	COG0778	Nitroreductase
AS53_282	COG0006	proline dipeptidase activity
AS53_2820	COG2719	SpoVR family
AS53_2825	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS53_2826	COG1937	Protein conserved in bacteria
AS53_2827	COG0425	Belongs to the sulfur carrier protein TusA family
AS53_2827	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS53_2828	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_2828	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS53_2829	COG0425	Belongs to the sulfur carrier protein TusA family
AS53_2831	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS53_2833	COG2210	Belongs to the sulfur carrier protein TusA family
AS53_2834	COG0730	response to heat
AS53_2836	COG1316	TRANSCRIPTIONal
AS53_2837	COG0604	alcohol dehydrogenase
AS53_2838	COG1283	sodium-dependent phosphate transmembrane transporter activity
AS53_2841	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS53_2841	COG3711	transcriptional antiterminator
AS53_2842	COG1447	Phosphotransferase system cellobiose-specific component IIA
AS53_2843	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AS53_2847	COG1388	LysM domain
AS53_2847	COG3584	3D domain protein
AS53_2848	COG0577	efflux transmembrane transporter activity
AS53_2849	COG1136	(ABC) transporter
AS53_285	COG3069	C4-dicarboxylate transmembrane transporter activity
AS53_2851	COG5522	Integral membrane protein (intg_mem_TP0381)
AS53_2854	COG1114	Component of the transport system for branched-chain amino acids
AS53_2855	COG3546	catalase activity
AS53_2862	COG0586	Pfam SNARE associated Golgi protein
AS53_2868	COG0531	amino acid
AS53_2869	COG0475	glutathione-regulated potassium exporter activity
AS53_2871	COG1737	Transcriptional regulator
AS53_2873	COG1263	PTS System
AS53_2873	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS53_2875	COG2259	Doxx family
AS53_2878	COG0697	spore germination
AS53_2879	COG1522	sequence-specific DNA binding
AS53_2881	COG2076	Multidrug Resistance protein
AS53_2882	COG2076	Multidrug Resistance protein
AS53_2883	COG1309	transcriptional regulator
AS53_2884	COG2814	Major facilitator Superfamily
AS53_2885	COG1733	regulation of RNA biosynthetic process
AS53_2887	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS53_2888	COG4533	DNA binding
AS53_2889	COG2211	Major facilitator Superfamily
AS53_2891	COG0693	protein deglycase activity
AS53_2892	COG0693	protein deglycase activity
AS53_2892	COG0753	catalase activity
AS53_2894	COG0531	amino acid
AS53_2895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AS53_2897	COG1012	belongs to the aldehyde dehydrogenase family
AS53_2898	COG1132	(ABC) transporter
AS53_2899	COG1132	(ABC) transporter
AS53_2900	COG1132	(ABC) transporter
AS53_2901	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS53_2902	COG0765	amino acid transport
AS53_2903	COG1126	abc transporter atp-binding protein
AS53_2906	COG0189	ligase activity
AS53_2912	COG0028	Belongs to the TPP enzyme family
AS53_2913	COG3527	Alpha-acetolactate decarboxylase
AS53_2916	COG0561	phosphatase activity
AS53_2918	COG3409	Peptidoglycan-binding domain 1 protein
AS53_2918	COG5632	N-Acetylmuramoyl-L-alanine amidase
AS53_2920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS53_2923	COG0659	secondary active sulfate transmembrane transporter activity
AS53_2927	COG0653	protein targeting
AS53_2928	COG2244	polysaccharide biosynthetic process
AS53_293	COG0505	Belongs to the CarA family
AS53_2930	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS53_2931	COG4196	transglutaminase domain protein
AS53_2934	COG1696	Membrane protein involved in D-alanine export
AS53_2937	COG1024	Enoyl-CoA hydratase
AS53_2940	COG1363	Peptidase, m42
AS53_2944	COG3938	Belongs to the proline racemase family
AS53_2951	COG0601	transmembrane transport
AS53_2952	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS53_2953	COG0444	Belongs to the ABC transporter superfamily
AS53_2954	COG0444	Belongs to the ABC transporter superfamily
AS53_2955	COG4608	Belongs to the ABC transporter superfamily
AS53_2956	COG0322	excinuclease ABC activity
AS53_2962	COG0477	Major facilitator Superfamily
AS53_2963	COG3290	protein histidine kinase activity
AS53_2964	COG4565	transcriptional regulatory protein
AS53_2965	COG3181	Tripartite tricarboxylate transporter family receptor
AS53_2970	COG0789	Transcriptional regulator
AS53_2970	COG4978	Transcriptional regulator
AS53_2973	COG0305	Participates in initiation and elongation during chromosome replication
AS53_298	COG0564	pseudouridine synthase activity
AS53_2981	COG0477	Major facilitator Superfamily
AS53_2991	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AS53_2991	COG3320	Male sterility
AS53_2996	COG1183	phosphatidylcholine synthase activity
AS53_3	COG0785	Cytochrome C biogenesis protein
AS53_3000	COG2376	Dihydroxyacetone kinase
AS53_3002	COG2376	Dihydroxyacetone kinase
AS53_3003	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS53_3004	COG1959	2 iron, 2 sulfur cluster binding
AS53_3009	COG3437	response regulator, receiver
AS53_3009	COG2770	Histidine kinase
AS53_301	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AS53_3019	COG3237	CsbD-like
AS53_302	COG3599	regulation of cell shape
AS53_3024	COG1191	sigma factor activity
AS53_3026	COG2208	phosphoserine phosphatase activity
AS53_3027	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AS53_3028	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS53_3028	COG2205	protein histidine kinase activity
AS53_3028	COG0784	Response regulator, receiver
AS53_3028	COG2198	Histidine kinase
AS53_303	COG2302	S4 RNA-binding domain
AS53_3033	COG0393	Putative heavy-metal-binding
AS53_3039	COG0420	3'-5' exonuclease activity
AS53_304	COG0762	integral membrane protein
AS53_3040	COG4717	serine-type aminopeptidase activity
AS53_3044	COG1309	transcriptional regulator
AS53_3045	COG2814	Major facilitator Superfamily
AS53_3046	COG0346	lactoylglutathione lyase activity
AS53_3049	COG0457	Tetratricopeptide repeat
AS53_3051	COG2267	carboxylic ester hydrolase activity
AS53_3055	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AS53_3056	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AS53_3058	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AS53_306	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AS53_3066	COG0477	Major facilitator Superfamily
AS53_3067	COG0477	Major facilitator Superfamily
AS53_3069	COG3973	AAA domain
AS53_3075	COG4980	gas vesicle protein
AS53_3076	COG0537	adenosine 5'-monophosphoramidase activity
AS53_3077	COG1131	(ABC) transporter
AS53_3078	COG4473	ABC transporter
AS53_308	COG1873	PFAM PRC-barrel domain
AS53_3081	COG1309	transcriptional regulator
AS53_3083	COG3402	PFAM membrane-flanked domain
AS53_3085	COG3428	Bacterial PH domain
AS53_309	COG1191	sigma factor activity
AS53_3095	COG3402	PFAM membrane-flanked domain
AS53_3096	COG3428	Bacterial PH domain
AS53_3097	COG2329	Antibiotic biosynthesis monooxygenase
AS53_3098	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS53_3099	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AS53_310	COG1191	sigma factor activity
AS53_3109	COG1309	transcriptional regulator
AS53_3110	COG1511	domain protein
AS53_3115	COG1609	Transcriptional regulator
AS53_3117	COG1234	tRNA 3'-trailer cleavage
AS53_3118	COG0095	Lipoate-protein ligase
AS53_312	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AS53_3120	COG0318	PFAM AMP-dependent synthetase and ligase
AS53_3126	COG3209	COG3209 Rhs family protein
AS53_313	COG0849	cell division
AS53_3133	COG1408	metallophosphoesterase
AS53_3134	COG1078	dGTPase activity
AS53_3136	COG1595	DNA-templated transcription, initiation
AS53_3137	COG2207	Transcriptional regulator
AS53_3137	COG3708	Transcriptional regulator
AS53_314	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AS53_3140	COG2205	protein histidine kinase activity
AS53_3141	COG0745	RESPONSE REGULATOR receiver
AS53_3146	COG0501	Belongs to the peptidase M48B family
AS53_3147	COG0840	transmembrane signaling receptor activity
AS53_3148	COG0697	spore germination
AS53_315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AS53_3151	COG0497	DNA recombination
AS53_3152	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AS53_3153	COG2224	Isocitrate lyase
AS53_3155	COG1278	Cold shock
AS53_3158	COG4903	ComK protein
AS53_3159	COG0398	Pfam SNARE associated Golgi protein
AS53_316	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AS53_3161	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AS53_3162	COG1074	ATP-dependent DNA helicase activity
AS53_317	COG0772	Belongs to the SEDS family
AS53_3170	COG0179	Fumarylacetoacetate (FAA) hydrolase
AS53_3175	COG0367	asparagine synthase
AS53_3177	COG0753	catalase activity
AS53_3178	COG0004	ammonium transporteR
AS53_3182	COG2996	Protein conserved in bacteria
AS53_3184	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS53_3186	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_3189	COG0561	phosphatase activity
AS53_3191	COG0542	response to heat
AS53_3193	COG2267	carboxylic ester hydrolase activity
AS53_3196	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS53_3197	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AS53_3198	COG5504	Zn-dependent protease
AS53_32	COG1695	Transcriptional regulator
AS53_320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AS53_3200	COG0180	Tryptophanyl-tRNA synthetase
AS53_3202	COG4166	transmembrane transport
AS53_3203	COG0601	transmembrane transport
AS53_3204	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS53_3205	COG0444	Belongs to the ABC transporter superfamily
AS53_3206	COG4608	Belongs to the ABC transporter superfamily
AS53_3207	COG0534	Mate efflux family protein
AS53_3208	COG4166	transmembrane transport
AS53_321	COG0768	penicillin binding
AS53_3210	COG1393	Belongs to the ArsC family
AS53_3211	COG0861	Integral membrane protein TerC family
AS53_3212	COG4862	establishment of competence for transformation
AS53_3213	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS53_3215	COG1164	Oligoendopeptidase f
AS53_3218	COG2346	COG2346, Truncated hemoglobins
AS53_3219	COG4116	CYTH
AS53_3221	COG2357	RelA SpoT domain protein
AS53_3222	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AS53_3223	COG0564	pseudouridine synthase activity
AS53_3227	COG0772	Belongs to the SEDS family
AS53_3228	COG0772	Belongs to the SEDS family
AS53_3229	COG1216	Glycosyl transferase, family 2
AS53_323	COG4839	cell division protein FtsL
AS53_3233	COG0463	Glycosyl transferase, family 2
AS53_3233	COG0457	Tetratricopeptide repeat
AS53_3237	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AS53_3240	COG1091	dTDP-4-dehydrorhamnose reductase activity
AS53_3248	COG2153	protein acetylation
AS53_3249	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AS53_3250	COG2382	esterase
AS53_3253	COG5492	domain, Protein
AS53_3254	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS53_3256	COG0512	Glutamine amidotransferase of anthranilate synthase
AS53_3256	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AS53_326	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AS53_3263	COG1620	l-lactate permease
AS53_3264	COG5634	Uncharacterized conserved protein (DUF2278)
AS53_3274	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS53_3276	COG1476	TRANSCRIPTIONal
AS53_3287	COG2226	methyltransferase
AS53_3289	COG1686	Belongs to the peptidase S11 family
AS53_3290	COG0681	Belongs to the peptidase S26 family
AS53_3296	COG1012	belongs to the aldehyde dehydrogenase family
AS53_3297	COG3842	ATPase activity
AS53_3298	COG1176	ABC-type spermidine putrescine transport system, permease component I
AS53_3299	COG1177	transmembrane transport
AS53_330	COG1399	metal-binding, possibly nucleic acid-binding protein
AS53_3300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AS53_3302	COG2409	Drug exporters of the RND superfamily
AS53_3304	COG0564	pseudouridine synthase activity
AS53_3306	COG2340	Cysteine-rich secretory protein family
AS53_3307	COG0247	lactate metabolic process
AS53_3308	COG0277	FAD linked oxidase domain protein
AS53_3309	COG3835	regulator
AS53_3311	COG0745	RESPONSE REGULATOR receiver
AS53_3312	COG5002	protein histidine kinase activity
AS53_3313	COG2186	Transcriptional regulator
AS53_3317	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AS53_3319	COG2116	formate transmembrane transporter activity
AS53_3320	COG0861	Integral membrane protein TerC family
AS53_3321	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS53_3323	COG2030	dehydratase
AS53_3327	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_3328	COG3243	poly(R)-hydroxyalkanoic acid synthase
AS53_3330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS53_3333	COG1840	ABC-type Fe3 transport system, periplasmic component
AS53_3335	COG3842	ATPase activity
AS53_3336	COG3842	ATPase activity
AS53_3339	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS53_3342	COG1349	DNA-binding transcription factor activity
AS53_3347	COG0235	Class ii aldolase
AS53_3350	COG2861	carbohydrate metabolic process
AS53_3352	COG3852	Histidine kinase
AS53_3353	COG1846	Transcriptional regulator
AS53_3355	COG2318	DinB family
AS53_3357	COG5002	protein histidine kinase activity
AS53_3359	COG0720	synthase
AS53_3362	COG4873	Protein conserved in bacteria
AS53_3368	COG1780	Probably involved in ribonucleotide reductase function
AS53_3369	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS53_3371	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS53_3372	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS53_3373	COG1725	Transcriptional regulator
AS53_3374	COG1131	(ABC) transporter
AS53_3376	COG1131	(ABC) transporter
AS53_3377	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AS53_3380	COG1522	sequence-specific DNA binding
AS53_3382	COG1335	isochorismatase
AS53_3384	COG1619	proteins homologs of microcin C7 resistance protein MccF
AS53_3385	COG2070	2-Nitropropane dioxygenase
AS53_3386	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AS53_3388	COG1696	Membrane protein involved in D-alanine export
AS53_3393	COG0716	FMN binding
AS53_3396	COG3173	Aminoglycoside phosphotransferase
AS53_340	COG4824	toxin secretion phage lysis holin
AS53_3400	COG0534	Mate efflux family protein
AS53_3401	COG1968	undecaprenyl-diphosphatase activity
AS53_3404	COG1846	Transcriptional regulator
AS53_3406	COG1301	dicarboxylic acid transport
AS53_3407	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS53_3408	COG4709	membrane
AS53_3409	COG3874	Sporulation protein YtfJ
AS53_3414	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS53_3415	COG0028	Belongs to the TPP enzyme family
AS53_3416	COG0440	acetolactate synthase activity
AS53_3417	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AS53_3419	COG0473	3-isopropylmalate dehydrogenase activity
AS53_3424	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AS53_3431	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AS53_3434	COG1183	phosphatidylcholine synthase activity
AS53_3435	COG1368	sulfuric ester hydrolase activity
AS53_3437	COG0019	diaminopimelate decarboxylase activity
AS53_3441	COG0529	Catalyzes the synthesis of activated sulfate
AS53_3442	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS53_3446	COG1648	precorrin-2 dehydrogenase activity
AS53_3447	COG0733	neurotransmitter:sodium symporter activity
AS53_3451	COG1757	Na H antiporter
AS53_3454	COG4758	membrane
AS53_3455	COG4585	Histidine kinase
AS53_3456	COG2197	response regulator
AS53_3458	COG1114	Component of the transport system for branched-chain amino acids
AS53_3460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AS53_3465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS53_3465	COG1017	nitric oxide dioxygenase activity
AS53_3468	COG0730	response to heat
AS53_3469	COG0306	phosphate transporter
AS53_3470	COG1392	Phosphate transport regulator
AS53_3471	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS53_3474	COG3852	Histidine kinase
AS53_3475	COG1801	Protein of unknown function DUF72
AS53_3477	COG0582	viral genome integration into host DNA
AS53_3478	COG5002	protein histidine kinase activity
AS53_3482	COG0392	lysyltransferase activity
AS53_3482	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AS53_3485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AS53_3486	COG1686	Belongs to the peptidase S11 family
AS53_3487	COG2715	membrane protein required for spore maturation
AS53_3488	COG0700	Nucleoside recognition
AS53_3489	COG1187	pseudouridine synthase activity
AS53_3491	COG1333	cytochrome c biogenesis protein
AS53_3492	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AS53_3493	COG0745	RESPONSE REGULATOR receiver
AS53_3494	COG5002	protein histidine kinase activity
AS53_3495	COG2096	Adenosyltransferase
AS53_3498	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AS53_3499	COG1141	Ferredoxin
AS53_3500	COG4955	Helix-turn-helix domain
AS53_3501	COG0514	ATP-dependent DNA helicase (RecQ)
AS53_3502	COG1266	CAAX protease self-immunity
AS53_3504	COG1408	metallophosphoesterase
AS53_3506	COG4862	establishment of competence for transformation
AS53_3507	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AS53_3511	COG0492	ferredoxin-NADP+ reductase activity
AS53_3512	COG0252	asparaginase activity
AS53_3526	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AS53_3529	COG0142	geranyltranstransferase activity
AS53_3531	COG0142	geranyltranstransferase activity
AS53_3532	COG0105	UTP biosynthetic process
AS53_3535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AS53_3536	COG0457	Tetratricopeptide repeat
AS53_3540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AS53_3542	COG4347	Protein of unknown function (DUF1405)
AS53_3545	COG2738	Putative neutral zinc metallopeptidase
AS53_3547	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_3548	COG1694	Mazg nucleotide pyrophosphohydrolase
AS53_3551	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS53_3552	COG0438	transferase activity, transferring glycosyl groups
AS53_3559	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AS53_3559	COG1199	ATP-dependent helicase activity
AS53_3563	COG3935	DnaD domain protein
AS53_3564	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AS53_3566	COG4499	WXG100 protein secretion system (Wss), protein YukC
AS53_3566	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS53_3575	COG4474	Belongs to the UPF0398 family
AS53_3577	COG0116	Belongs to the methyltransferase superfamily
AS53_3579	COG1199	ATP-dependent helicase activity
AS53_3580	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AS53_3582	COG3173	Aminoglycoside phosphotransferase
AS53_3583	COG0024	Methionine aminopeptidase
AS53_3585	COG2233	PERMEase
AS53_3586	COG2311	Membrane
AS53_3588	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AS53_359	COG1802	Transcriptional regulator
AS53_359	COG4626	Terminase
AS53_3590	COG0456	acetyltransferase
AS53_3595	COG0754	glutathionylspermidine amidase activity
AS53_3598	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS53_3605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AS53_3608	COG1215	transferase activity, transferring glycosyl groups
AS53_3609	COG0438	transferase activity, transferring glycosyl groups
AS53_3612	COG0454	-acetyltransferase
AS53_3616	COG0328	RNA-DNA hybrid ribonuclease activity
AS53_3624	COG1280	lysine exporter protein (LysE YggA)
AS53_3627	COG3162	membrane
AS53_3628	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS53_3629	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS53_3631	COG0475	glutathione-regulated potassium exporter activity
AS53_3632	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS53_3633	COG0789	Transcriptional regulator
AS53_3633	COG4978	Transcriptional regulator
AS53_3635	COG2323	membrane
AS53_3636	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AS53_364	COG0582	viral genome integration into host DNA
AS53_3647	COG1923	regulation of RNA biosynthetic process
AS53_3649	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AS53_3650	COG1360	Flagellar Motor Protein
AS53_3651	COG2201	protein-glutamate methylesterase activity
AS53_3652	COG0643	Histidine kinase
AS53_3652	COG2198	Histidine kinase
AS53_3653	COG2198	Histidine kinase
AS53_3653	COG0643	Histidine kinase
AS53_3654	COG1776	CheC inhibitor of MCP methylation
AS53_3654	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AS53_3657	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AS53_3661	COG1256	bacterial-type flagellum assembly
AS53_3662	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AS53_3667	COG1815	bacterial-type flagellum-dependent cell motility
AS53_3668	COG1558	bacterial-type flagellum-dependent cell motility
AS53_3669	COG1677	Flagellar hook-basal body complex protein FliE
AS53_3670	COG1766	The M ring may be actively involved in energy transduction
AS53_3672	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AS53_3674	COG1157	protein secretion by the type III secretion system
AS53_3683	COG0835	chemotaxis
AS53_3683	COG0784	Response regulator, receiver
AS53_3685	COG0463	Glycosyl transferase, family 2
AS53_3691	COG0463	Glycosyl transferase, family 2
AS53_3691	COG0457	Tetratricopeptide repeat
AS53_3696	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AS53_3697	COG0741	lytic transglycosylase activity
AS53_3698	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AS53_3700	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AS53_3700	COG1776	CheC inhibitor of MCP methylation
AS53_3702	COG1338	Plays a role in the flagellum-specific transport system
AS53_3703	COG1987	bacterial-type flagellum assembly
AS53_3705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AS53_3706	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AS53_3707	COG1419	protein localization to endoplasmic reticulum
AS53_3708	COG4786	Flagellar basal body rod
AS53_3709	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AS53_3714	COG1309	transcriptional regulator
AS53_3718	COG2329	Antibiotic biosynthesis monooxygenase
AS53_3724	COG3842	ATPase activity
AS53_3725	COG0725	ABC transporter, periplasmic molybdate-binding protein
AS53_3726	COG1177	transmembrane transport
AS53_3727	COG1234	tRNA 3'-trailer cleavage
AS53_3732	COG1686	Belongs to the peptidase S11 family
AS53_3734	COG0406	alpha-ribazole phosphatase activity
AS53_3741	COG0367	asparagine synthase
AS53_3747	COG1802	Transcriptional regulator
AS53_3748	COG0697	spore germination
AS53_3749	COG0523	cobalamin synthesis protein
AS53_3750	COG0701	Predicted permease
AS53_3752	COG0438	transferase activity, transferring glycosyl groups
AS53_3752	COG1216	Glycosyl transferase, family 2
AS53_3753	COG1757	Na H antiporter
AS53_3754	COG0114	fumarate hydratase activity
AS53_3758	COG0534	Mate efflux family protein
AS53_3759	COG0534	Mate efflux family protein
AS53_3760	COG3340	Belongs to the peptidase S51 family
AS53_3765	COG0785	Cytochrome C biogenesis protein
AS53_3772	COG2733	membrane
AS53_3779	COG1131	(ABC) transporter
AS53_3782	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS53_3783	COG0528	UMP kinase activity
AS53_3785	COG1027	Aspartate ammonia-lyase
AS53_3786	COG0281	malic enzyme
AS53_3787	COG4191	Histidine kinase
AS53_3788	COG0784	Response regulator, receiver
AS53_3789	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS53_379	COG1191	sigma factor activity
AS53_3800	COG1051	belongs to the nudix hydrolase family
AS53_3801	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS53_3806	COG1966	Carbon starvation protein
AS53_3808	COG0477	Major facilitator Superfamily
AS53_3809	COG0477	Major facilitator Superfamily
AS53_3810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS53_3812	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AS53_3814	COG4166	transmembrane transport
AS53_3815	COG2223	nitrite transmembrane transporter activity
AS53_3816	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS53_3819	COG2244	polysaccharide biosynthetic process
AS53_3820	COG0733	neurotransmitter:sodium symporter activity
AS53_3822	COG5566	PFAM Mor transcription activator
AS53_3823	COG2323	membrane
AS53_3826	COG2084	Dehydrogenase
AS53_3830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS53_3832	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS53_3833	COG0028	Belongs to the TPP enzyme family
AS53_3834	COG0440	acetolactate synthase activity
AS53_3835	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AS53_3837	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AS53_384	COG1484	DNA-dependent DNA replication
AS53_3842	COG2814	Major facilitator Superfamily
AS53_3843	COG3384	dioxygenase
AS53_3845	COG3279	Response regulator of the LytR AlgR family
AS53_3846	COG0427	acetyl-CoA hydrolase
AS53_3850	COG1073	alpha beta
AS53_3851	COG4166	transmembrane transport
AS53_3857	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_3862	COG1914	H( )-stimulated, divalent metal cation uptake system
AS53_3865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AS53_3867	COG0531	amino acid
AS53_3868	COG0531	amino acid
AS53_3873	COG2390	Transcriptional regulator
AS53_3875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS53_3876	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AS53_3878	COG4224	UPF0291 protein
AS53_3882	COG0006	proline dipeptidase activity
AS53_3883	COG2132	Multicopper oxidase
AS53_3889	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS53_3890	COG1114	Component of the transport system for branched-chain amino acids
AS53_3891	COG1114	Component of the transport system for branched-chain amino acids
AS53_3893	COG2372	response to copper ion
AS53_3893	COG1276	copper resistance
AS53_3894	COG4549	nuclear export factor GLE1
AS53_3896	COG0697	spore germination
AS53_3897	COG0583	DNA-binding transcription factor activity
AS53_3898	COG1959	2 iron, 2 sulfur cluster binding
AS53_3899	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AS53_390	COG1396	sequence-specific DNA binding
AS53_3900	COG0778	Nitroreductase
AS53_3903	COG0628	permease
AS53_3904	COG0039	L-malate dehydrogenase activity
AS53_3905	COG1231	oxidoreductase activity
AS53_3906	COG0523	cobalamin synthesis protein
AS53_3909	COG0318	PFAM AMP-dependent synthetase and ligase
AS53_3910	COG2030	dehydratase
AS53_3911	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS53_3913	COG0411	ABC transporter
AS53_3917	COG0583	DNA-binding transcription factor activity
AS53_3919	COG1942	4-Oxalocrotonate Tautomerase
AS53_3921	COG1846	Transcriptional regulator
AS53_3923	COG1271	oxidase subunit
AS53_3924	COG1294	oxidase, subunit
AS53_3925	COG4988	ABC transporter
AS53_3926	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AS53_3930	COG1686	Belongs to the peptidase S11 family
AS53_3932	COG0791	NLP P60 protein
AS53_3932	COG1388	LysM domain
AS53_3934	COG1132	(ABC) transporter
AS53_3935	COG1132	(ABC) transporter
AS53_3936	COG0745	RESPONSE REGULATOR receiver
AS53_3937	COG5002	protein histidine kinase activity
AS53_394	COG1396	sequence-specific DNA binding
AS53_3942	COG0726	polysaccharide deacetylase
AS53_3946	COG0460	homoserine dehydrogenase
AS53_3951	COG1316	TRANSCRIPTIONal
AS53_3953	COG0745	RESPONSE REGULATOR receiver
AS53_3954	COG5002	protein histidine kinase activity
AS53_3955	COG0726	polysaccharide deacetylase
AS53_3957	COG1285	pathogenesis
AS53_3958	COG1247	-acetyltransferase
AS53_3960	COG4264	IucA IucC family
AS53_3961	COG0318	PFAM AMP-dependent synthetase and ligase
AS53_3964	COG1082	Xylose isomerase domain protein TIM barrel
AS53_3966	COG2814	Major facilitator Superfamily
AS53_3967	COG2814	Major facilitator Superfamily
AS53_3968	COG1279	arginine transmembrane transporter activity
AS53_3970	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS53_3977	COG0577	efflux transmembrane transporter activity
AS53_3978	COG0577	efflux transmembrane transporter activity
AS53_3979	COG2002	toxin-antitoxin pair type II binding
AS53_398	COG0582	viral genome integration into host DNA
AS53_3980	COG1404	Belongs to the peptidase S8 family
AS53_3981	COG0640	Transcriptional regulator
AS53_3982	COG0667	Aldo Keto reductase
AS53_3983	COG2814	Major facilitator Superfamily
AS53_3988	COG0840	transmembrane signaling receptor activity
AS53_3991	COG3949	Membrane
AS53_3992	COG0783	Belongs to the Dps family
AS53_3995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS53_3997	COG1231	oxidoreductase activity
AS53_3999	COG4989	oxidoreductase activity
AS53_40	COG5632	N-Acetylmuramoyl-L-alanine amidase
AS53_40	COG1388	LysM domain
AS53_40	COG3409	Peptidoglycan-binding domain 1 protein
AS53_400	COG3480	Lon protease (S16) C-terminal proteolytic domain
AS53_4000	COG0523	cobalamin synthesis protein
AS53_4001	COG0456	acetyltransferase
AS53_401	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS53_4011	COG3443	Belongs to the bacterial solute-binding protein 9 family
AS53_4011	COG0803	Belongs to the bacterial solute-binding protein 9 family
AS53_4013	COG0702	epimerase
AS53_4015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AS53_4017	COG4166	transmembrane transport
AS53_4020	COG0406	alpha-ribazole phosphatase activity
AS53_4022	COG5337	Spore coat protein CotH
AS53_4023	COG1051	belongs to the nudix hydrolase family
AS53_4024	COG0586	Pfam SNARE associated Golgi protein
AS53_4025	COG2244	polysaccharide biosynthetic process
AS53_4027	COG0701	Predicted permease
AS53_4028	COG3689	TIGRFAM TIGR03943 family protein
AS53_4029	COG1607	acyl-coa hydrolase
AS53_403	COG3314	Sporulation integral membrane protein YlbJ
AS53_4030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS53_4033	COG0702	epimerase
AS53_4034	COG2839	Protein conserved in bacteria
AS53_4035	COG1253	flavin adenine dinucleotide binding
AS53_4038	COG1114	Component of the transport system for branched-chain amino acids
AS53_4039	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS53_404	COG0742	ribosomal rna small subunit methyltransferase
AS53_4043	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS53_4045	COG1876	peptidase activity
AS53_4047	COG0154	amidase activity
AS53_4048	COG2211	Major facilitator Superfamily
AS53_4052	COG0561	phosphatase activity
AS53_4054	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AS53_4058	COG1819	glycosyl
AS53_4059	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_4060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_4066	COG0456	acetyltransferase
AS53_4075	COG3874	Sporulation protein YtfJ
AS53_408	COG3679	Belongs to the UPF0342 family
AS53_4080	COG2226	methyltransferase
AS53_4084	COG1082	Xylose isomerase domain protein TIM barrel
AS53_4085	COG0346	lactoylglutathione lyase activity
AS53_4087	COG0604	alcohol dehydrogenase
AS53_4088	COG1595	DNA-templated transcription, initiation
AS53_409	COG0406	alpha-ribazole phosphatase activity
AS53_4093	COG0386	Belongs to the glutathione peroxidase family
AS53_4094	COG1305	Transglutaminase-like
AS53_4095	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AS53_4096	COG0714	Associated with various cellular activities
AS53_4099	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AS53_41	COG4824	toxin secretion phage lysis holin
AS53_4100	COG1140	nitrate reductase beta subunit
AS53_4101	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AS53_4102	COG2181	nitrate reductase activity
AS53_4106	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS53_4107	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AS53_4108	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS53_4109	COG0303	'Molybdopterin
AS53_4110	COG0314	molybdopterin synthase activity
AS53_4112	COG2223	nitrite transmembrane transporter activity
AS53_4115	COG1648	precorrin-2 dehydrogenase activity
AS53_4117	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AS53_4117	COG1587	Uroporphyrinogen-III synthase
AS53_4118	COG2146	nitrite reductase [NAD(P)H] activity
AS53_4119	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS53_412	COG2340	Cysteine-rich secretory protein family
AS53_4120	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AS53_4127	COG2359	stage V sporulation protein S
AS53_4130	COG5632	N-Acetylmuramoyl-L-alanine amidase
AS53_4133	COG1418	mRNA catabolic process
AS53_4134	COG0488	(ABC) transporter
AS53_4137	COG0629	single-stranded DNA binding
AS53_4140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS53_4141	COG1413	lyase activity
AS53_4144	COG2521	methyltransferase
AS53_4144	COG2136	Putative SAM-dependent methyltransferase
AS53_4145	COG0018	arginyl-trna synthetase
AS53_415	COG3336	cytochrome c oxidase
AS53_4151	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AS53_4154	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AS53_4155	COG0017	Asparaginyl-tRNA synthetase
AS53_4159	COG1674	ftsk spoiiie
AS53_4178	COG1929	Belongs to the glycerate kinase type-1 family
AS53_4179	COG0471	metal ion transport
AS53_4180	COG0745	RESPONSE REGULATOR receiver
AS53_4181	COG5002	protein histidine kinase activity
AS53_4181	COG3850	Histidine kinase
AS53_4184	COG0733	neurotransmitter:sodium symporter activity
AS53_4189	COG2610	gluconate transmembrane transporter activity
AS53_4190	COG1454	alcohol dehydrogenase
AS53_4191	COG1794	racemase activity, acting on amino acids and derivatives
AS53_4193	COG0456	acetyltransferase
AS53_4195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AS53_4197	COG1131	(ABC) transporter
AS53_4198	COG4473	ABC transporter
AS53_4200	COG0546	phosphoglycolate phosphatase activity
AS53_4204	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AS53_4207	COG0768	penicillin binding
AS53_4208	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS53_4209	COG0204	Acyl-transferase
AS53_4210	COG1272	protein, Hemolysin III
AS53_4212	COG0805	protein transport
AS53_4214	COG1307	EDD domain protein, DegV family
AS53_4215	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AS53_4216	COG1999	signal sequence binding
AS53_4217	COG0071	Belongs to the small heat shock protein (HSP20) family
AS53_4218	COG0367	asparagine synthase
AS53_422	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AS53_4222	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_4223	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS53_4227	COG1335	isochorismatase
AS53_4228	COG1051	belongs to the nudix hydrolase family
AS53_423	COG0772	Belongs to the SEDS family
AS53_4230	COG0668	transmembrane transport
AS53_4231	COG4585	Histidine kinase
AS53_4231	COG2203	Gaf domain
AS53_4232	COG2197	response regulator
AS53_4234	COG1737	Transcriptional regulator
AS53_4235	COG1064	alcohol dehydrogenase
AS53_424	COG4838	Belongs to the UPF0358 family
AS53_4242	COG1070	Carbohydrate kinase
AS53_4249	COG1125	glycine betaine transport
AS53_4249	COG0517	IMP dehydrogenase activity
AS53_425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AS53_4250	COG1174	glycine betaine transport
AS53_4257	COG1253	flavin adenine dinucleotide binding
AS53_4258	COG1012	belongs to the aldehyde dehydrogenase family
AS53_4259	COG5506	Protein of unknown function (DUF1694)
AS53_426	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AS53_4262	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS53_4263	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS53_4264	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS53_4265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS53_4266	COG0456	acetyltransferase
AS53_4267	COG3829	transcription factor binding
AS53_4268	COG1509	lysine 2,3-aminomutase activity
AS53_4276	COG4326	sporulation control protein
AS53_4277	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AS53_4278	COG0671	phosphoesterase, PA-phosphatase related
AS53_4279	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS53_428	COG4896	Protein conserved in bacteria
AS53_4284	COG1715	Restriction endonuclease
AS53_4284	COG1787	Restriction endonuclease
AS53_4300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS53_4308	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS53_4308	COG4499	WXG100 protein secretion system (Wss), protein YukC
AS53_4309	COG2814	Major facilitator Superfamily
AS53_4310	COG4841	protein insertion into membrane
AS53_4311	COG0372	Belongs to the citrate synthase family
AS53_4312	COG2079	MmgE PrpD family protein
AS53_4313	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AS53_4314	COG1960	acyl-CoA dehydrogenase activity
AS53_4315	COG2084	Dehydrogenase
AS53_4316	COG1012	belongs to the aldehyde dehydrogenase family
AS53_4317	COG1280	lysine exporter protein (LysE YggA)
AS53_4318	COG1024	Enoyl-CoA hydratase
AS53_4321	COG0420	3'-5' exonuclease activity
AS53_4322	COG0419	ATPase involved in DNA repair
AS53_4326	COG2223	nitrite transmembrane transporter activity
AS53_4327	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_4328	COG1169	isochorismate synthase
AS53_4329	COG1021	2,3-dihydroxybenzoate-AMP ligase
AS53_433	COG0483	inositol monophosphate 1-phosphatase activity
AS53_4330	COG3433	isochorismatase activity
AS53_4330	COG1535	isochorismatase
AS53_4331	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AS53_4332	COG3251	PFAM MbtH domain protein
AS53_4333	COG2814	Major facilitator Superfamily
AS53_4336	COG0776	regulation of translation
AS53_4338	COG2318	DinB family
AS53_4340	COG1115	amino acid carrier protein
AS53_4343	COG2329	Antibiotic biosynthesis monooxygenase
AS53_4344	COG1187	pseudouridine synthase activity
AS53_4345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AS53_4349	COG0596	Alpha beta hydrolase
AS53_4350	COG2814	Major facilitator Superfamily
AS53_4355	COG2226	methyltransferase
AS53_4364	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_437	COG1982	Orn Lys Arg decarboxylase major
AS53_4371	COG1247	-acetyltransferase
AS53_4379	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_4381	COG1278	Cold shock
AS53_4384	COG0010	Belongs to the arginase family
AS53_4385	COG0561	phosphatase activity
AS53_4393	COG0583	DNA-binding transcription factor activity
AS53_4394	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AS53_4397	COG0583	DNA-binding transcription factor activity
AS53_4398	COG2258	MOSC domain
AS53_4401	COG1132	(ABC) transporter
AS53_4402	COG1132	(ABC) transporter
AS53_4406	COG1396	sequence-specific DNA binding
AS53_4411	COG1595	DNA-templated transcription, initiation
AS53_4416	COG1649	PFAM Uncharacterised BCR, COG1649
AS53_4421	COG2971	BadF BadG BcrA BcrD
AS53_4422	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AS53_4423	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AS53_4426	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_4431	COG1309	transcriptional regulator
AS53_4434	COG1136	(ABC) transporter
AS53_4434	COG0577	efflux transmembrane transporter activity
AS53_4435	COG3615	Tellurite resistance protein tehB
AS53_4435	COG0500	methyltransferase
AS53_4437	COG2226	methyltransferase
AS53_4438	COG3961	Belongs to the TPP enzyme family
AS53_4439	COG1846	Transcriptional regulator
AS53_4447	COG2195	Cleaves the N-terminal amino acid of tripeptides
AS53_4451	COG1595	DNA-templated transcription, initiation
AS53_4453	COG0768	penicillin binding
AS53_4456	COG2367	Beta-lactamase
AS53_4457	COG0671	phosphoesterase, PA-phosphatase related
AS53_4458	COG1609	Transcriptional regulator
AS53_4459	COG2814	Major facilitator Superfamily
AS53_446	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS53_4460	COG0673	inositol 2-dehydrogenase activity
AS53_4462	COG1012	belongs to the aldehyde dehydrogenase family
AS53_4466	COG3718	enzyme involved in inositol metabolism
AS53_447	COG0022	dehydrogenase e1 component
AS53_4470	COG0737	Belongs to the 5'-nucleotidase family
AS53_4471	COG0737	Belongs to the 5'-nucleotidase family
AS53_4473	COG0457	Tetratricopeptide repeat
AS53_4474	COG1476	TRANSCRIPTIONal
AS53_4477	COG1876	peptidase activity
AS53_448	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AS53_4482	COG1309	transcriptional regulator
AS53_4486	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_4488	COG1252	NADH dehydrogenase
AS53_4489	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS53_4492	COG1131	(ABC) transporter
AS53_4497	COG1960	acyl-CoA dehydrogenase activity
AS53_4498	COG0439	Biotin carboxylase
AS53_4499	COG0511	ligase activity, forming carbon-carbon bonds
AS53_450	COG0242	peptide deformylase activity
AS53_4500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AS53_4501	COG1024	Enoyl-CoA hydratase
AS53_4502	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AS53_4503	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS53_4505	COG1247	-acetyltransferase
AS53_4506	COG0572	uridine kinase
AS53_4508	COG2318	DinB family
AS53_4509	COG1686	Belongs to the peptidase S11 family
AS53_451	COG0561	phosphatase activity
AS53_4514	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AS53_4518	COG3227	Zinc metalloprotease (Elastase)
AS53_4523	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AS53_4523	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AS53_4526	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AS53_4528	COG2814	Major facilitator Superfamily
AS53_453	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS53_4532	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AS53_4536	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_4538	COG1063	alcohol dehydrogenase
AS53_454	COG0569	domain protein
AS53_4541	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AS53_4542	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AS53_4545	COG3773	Cell wall hydrolase
AS53_4547	COG0745	RESPONSE REGULATOR receiver
AS53_4549	COG2205	protein histidine kinase activity
AS53_4554	COG1136	(ABC) transporter
AS53_4555	COG0577	efflux transmembrane transporter activity
AS53_4556	COG0577	efflux transmembrane transporter activity
AS53_4560	COG0460	homoserine dehydrogenase
AS53_4561	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_4563	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AS53_4579	COG2124	cytochrome p450
AS53_458	COG0583	DNA-binding transcription factor activity
AS53_4586	COG0561	phosphatase activity
AS53_4588	COG5002	protein histidine kinase activity
AS53_459	COG0517	IMP dehydrogenase activity
AS53_4590	COG1819	glycosyl
AS53_4591	COG1794	racemase activity, acting on amino acids and derivatives
AS53_4593	COG1122	ATPase activity
AS53_4596	COG2205	protein histidine kinase activity
AS53_4599	COG0604	alcohol dehydrogenase
AS53_4602	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AS53_4608	COG0693	protein deglycase activity
AS53_461	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AS53_4613	COG2814	Major facilitator Superfamily
AS53_4617	COG0584	glycerophosphoryl diester phosphodiesterase
AS53_4620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_4621	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_4622	COG0697	spore germination
AS53_4629	COG2223	nitrite transmembrane transporter activity
AS53_463	COG4703	Protein of unknown function (DUF1797)
AS53_4631	COG2816	NAD+ diphosphatase activity
AS53_4632	COG0592	DNA-directed DNA polymerase activity
AS53_4633	COG1051	belongs to the nudix hydrolase family
AS53_4640	COG3878	Protein conserved in bacteria
AS53_4646	COG4667	esterase of the alpha-beta hydrolase superfamily
AS53_4651	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS53_4654	COG0322	excinuclease ABC activity
AS53_466	COG2200	EAL domain
AS53_4662	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS53_4667	COG1011	Hydrolase
AS53_467	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_4672	COG0076	glutamate decarboxylase activity
AS53_4675	COG1523	belongs to the glycosyl hydrolase 13 family
AS53_4676	COG3227	Zinc metalloprotease (Elastase)
AS53_468	COG1408	metallophosphoesterase
AS53_4680	COG0201	protein transport
AS53_4682	COG0697	spore germination
AS53_4683	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_4689	COG4129	membrane
AS53_4690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_4693	COG2959	enzyme of heme biosynthesis
AS53_4694	COG3409	Peptidoglycan-binding domain 1 protein
AS53_4694	COG3773	Cell wall hydrolase
AS53_4697	COG3483	tryptophan 2,3-dioxygenase activity
AS53_4698	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AS53_4699	COG3844	kynureninase activity
AS53_470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AS53_4700	COG1309	transcriptional regulator
AS53_4706	COG3284	Transcriptional regulator
AS53_4710	COG1349	DNA-binding transcription factor activity
AS53_4714	COG1959	2 iron, 2 sulfur cluster binding
AS53_4718	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS53_4719	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS53_4720	COG0022	dehydrogenase e1 component
AS53_4721	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AS53_4723	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_4724	COG0456	acetyltransferase
AS53_4724	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS53_4730	COG4176	ABC-type proline glycine betaine transport system permease component
AS53_4731	COG4175	Glycine betaine
AS53_4731	COG0517	IMP dehydrogenase activity
AS53_4733	COG0740	serine-type endopeptidase activity
AS53_4736	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AS53_4737	COG2153	protein acetylation
AS53_4738	COG3397	chitin binding
AS53_4742	COG2205	protein histidine kinase activity
AS53_4747	COG2333	competence protein COMEC
AS53_4747	COG0658	competence protein
AS53_4758	COG3973	AAA domain
AS53_4761	COG2105	PFAM AIG2 family protein
AS53_4762	COG0514	ATP-dependent DNA helicase (RecQ)
AS53_4766	COG4637	Psort location Cytoplasmic, score
AS53_477	COG2814	Major facilitator Superfamily
AS53_4771	COG3397	chitin binding
AS53_4773	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS53_4774	COG1115	amino acid carrier protein
AS53_4775	COG1012	belongs to the aldehyde dehydrogenase family
AS53_4776	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS53_4778	COG3938	Belongs to the proline racemase family
AS53_4779	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS53_4786	COG0586	Pfam SNARE associated Golgi protein
AS53_4789	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AS53_4790	COG0519	Catalyzes the synthesis of GMP from XMP
AS53_4791	COG4166	transmembrane transport
AS53_4793	COG4948	Mandelate Racemase Muconate Lactonizing
AS53_4801	COG2936	dipeptidyl-peptidase activity
AS53_4802	COG5002	protein histidine kinase activity
AS53_4803	COG0745	RESPONSE REGULATOR receiver
AS53_481	COG3209	COG3209 Rhs family protein
AS53_4810	COG1164	Oligoendopeptidase f
AS53_4813	COG1307	EDD domain protein, DegV family
AS53_4817	COG2814	Major facilitator Superfamily
AS53_4819	COG1664	Polymer-forming cytoskeletal
AS53_4820	COG0789	Transcriptional regulator
AS53_4821	COG4533	DNA binding
AS53_4822	COG2814	Major facilitator Superfamily
AS53_4822	COG0477	Major facilitator Superfamily
AS53_4826	COG2261	transglycosylase associated protein
AS53_4829	COG2226	methyltransferase
AS53_483	COG2205	protein histidine kinase activity
AS53_4835	COG0436	Aminotransferase
AS53_4836	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AS53_4837	COG5146	pantothenate kinase activity
AS53_4841	COG1131	(ABC) transporter
AS53_485	COG0436	Aminotransferase
AS53_4850	COG0628	permease
AS53_4852	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS53_4853	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS53_4854	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS53_4855	COG1116	anion transmembrane transporter activity
AS53_486	COG1609	Transcriptional regulator
AS53_4863	COG2746	aminoglycoside 3-N-acetyltransferase activity
AS53_4868	COG0697	spore germination
AS53_4869	COG2318	DinB family
AS53_487	COG3833	ABC-type maltose transport systems, permease component
AS53_4873	COG4912	Dna alkylation repair
AS53_4875	COG0726	polysaccharide deacetylase
AS53_4877	COG0861	Integral membrane protein TerC family
AS53_4878	COG1368	sulfuric ester hydrolase activity
AS53_4879	COG0488	(ABC) transporter
AS53_488	COG1175	transmembrane transport
AS53_4881	COG1033	growth of symbiont in host cell
AS53_4881	COG2409	Drug exporters of the RND superfamily
AS53_4882	COG2409	Drug exporters of the RND superfamily
AS53_4882	COG1033	growth of symbiont in host cell
AS53_4883	COG1309	transcriptional regulator
AS53_4886	COG0287	Prephenate dehydrogenase
AS53_4887	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AS53_4888	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AS53_4889	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AS53_4889	COG1605	Chorismate mutase
AS53_489	COG2182	Extracellular solute-binding protein
AS53_4897	COG1388	LysM domain
AS53_4897	COG3584	3D domain protein
AS53_4899	COG1595	DNA-templated transcription, initiation
AS53_4905	COG1879	ABC-type sugar transport system periplasmic component
AS53_4907	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS53_4909	COG2390	Transcriptional regulator
AS53_491	COG0366	Alpha amylase catalytic
AS53_4910	COG1070	Carbohydrate kinase
AS53_4917	COG2329	Antibiotic biosynthesis monooxygenase
AS53_492	COG3842	ATPase activity
AS53_4921	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS53_4923	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AS53_4924	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS53_4925	COG4187	Peptidase family M20/M25/M40
AS53_4926	COG1414	Transcriptional regulator
AS53_4927	COG0833	amino acid
AS53_4928	COG1690	Belongs to the RtcB family
AS53_4929	COG3239	Fatty acid desaturase
AS53_4930	COG1785	Belongs to the alkaline phosphatase family
AS53_4932	COG3655	Transcriptional regulator
AS53_4935	COG4377	Putative membrane peptidase family (DUF2324)
AS53_4937	COG3279	Response regulator of the LytR AlgR family
AS53_4939	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_4940	COG0346	lactoylglutathione lyase activity
AS53_4944	COG0714	Associated with various cellular activities
AS53_4949	COG0463	Glycosyl transferase, family 2
AS53_4954	COG0463	Glycosyl transferase, family 2
AS53_4956	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AS53_4957	COG0753	catalase activity
AS53_4959	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AS53_4965	COG0714	Associated with various cellular activities
AS53_4967	COG0778	Nitroreductase
AS53_4968	COG1846	Transcriptional regulator
AS53_4975	COG1725	Transcriptional regulator
AS53_4977	COG0577	efflux transmembrane transporter activity
AS53_4977	COG1136	(ABC) transporter
AS53_4982	COG2207	Transcriptional regulator
AS53_4983	COG0456	acetyltransferase
AS53_4987	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_4991	COG0642	Histidine kinase
AS53_4992	COG0745	RESPONSE REGULATOR receiver
AS53_4993	COG0596	Alpha beta hydrolase
AS53_4999	COG0730	response to heat
AS53_5	COG0583	DNA-binding transcription factor activity
AS53_500	COG0183	Belongs to the thiolase family
AS53_5001	COG0833	amino acid
AS53_5003	COG4335	DNA alkylation repair
AS53_5013	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AS53_5019	COG1984	allophanate hydrolase subunit 2
AS53_5020	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AS53_5021	COG1414	Transcriptional regulator
AS53_5024	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS53_5025	COG0640	Transcriptional regulator
AS53_5027	COG1960	acyl-CoA dehydrogenase activity
AS53_5034	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AS53_5037	COG3848	Pyruvate phosphate dikinase
AS53_5037	COG0574	Belongs to the PEP-utilizing enzyme family
AS53_5038	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_5041	COG5577	PFAM Coat F domain
AS53_5043	COG3403	YqcI/YcgG family
AS53_5044	COG1280	lysine exporter protein (LysE YggA)
AS53_5045	COG1113	amino acid transport
AS53_5046	COG1113	amino acid transport
AS53_5052	COG1063	alcohol dehydrogenase
AS53_5055	COG1027	Aspartate ammonia-lyase
AS53_5056	COG0252	asparaginase activity
AS53_5057	COG1396	sequence-specific DNA binding
AS53_5059	COG0322	excinuclease ABC activity
AS53_5060	COG0531	amino acid
AS53_5061	COG1114	Component of the transport system for branched-chain amino acids
AS53_5062	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS53_5064	COG0281	malic enzyme
AS53_5068	COG0531	amino acid
AS53_5069	COG0697	spore germination
AS53_507	COG1695	Transcriptional regulator
AS53_5070	COG0784	Response regulator, receiver
AS53_5071	COG4191	Histidine kinase
AS53_5072	COG4191	Histidine kinase
AS53_5073	COG2066	Belongs to the glutaminase family
AS53_5075	COG1115	amino acid carrier protein
AS53_508	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_5081	COG0737	Belongs to the 5'-nucleotidase family
AS53_5082	COG0753	catalase activity
AS53_5083	COG2267	carboxylic ester hydrolase activity
AS53_5084	COG1335	isochorismatase
AS53_5089	COG0583	DNA-binding transcription factor activity
AS53_5090	COG1846	Transcriptional regulator
AS53_5091	COG0598	Magnesium transport protein CorA
AS53_5092	COG0598	Magnesium transport protein CorA
AS53_5099	COG0415	Belongs to the DNA photolyase family
AS53_5100	COG0288	reversible hydration of carbon dioxide
AS53_5102	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AS53_5103	COG5609	conserved protein (DUF2294)
AS53_5105	COG1575	Belongs to the MenA family. Type 1 subfamily
AS53_5106	COG2267	carboxylic ester hydrolase activity
AS53_5107	COG0803	Belongs to the bacterial solute-binding protein 9 family
AS53_5108	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AS53_5109	COG1121	(ABC) transporter
AS53_5115	COG0798	PFAM Bile acid sodium symporter
AS53_5116	COG0346	lactoylglutathione lyase activity
AS53_5117	COG0640	Transcriptional regulator
AS53_512	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS53_5121	COG0443	Heat shock 70 kDa protein
AS53_5124	COG1522	sequence-specific DNA binding
AS53_5127	COG0346	lactoylglutathione lyase activity
AS53_513	COG0436	Aminotransferase
AS53_5139	COG2814	Major facilitator Superfamily
AS53_5144	COG0745	RESPONSE REGULATOR receiver
AS53_5145	COG3850	Histidine kinase
AS53_5145	COG5002	protein histidine kinase activity
AS53_5150	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AS53_5156	COG1476	TRANSCRIPTIONal
AS53_5159	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_5160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS53_5162	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS53_5163	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AS53_5166	COG1136	(ABC) transporter
AS53_5167	COG0577	efflux transmembrane transporter activity
AS53_517	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AS53_5170	COG5002	protein histidine kinase activity
AS53_5170	COG3850	Histidine kinase
AS53_5172	COG2364	Membrane
AS53_5173	COG1846	Transcriptional regulator
AS53_5174	COG0456	acetyltransferase
AS53_5175	COG2808	Putative FMN-binding domain
AS53_5176	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_5177	COG2271	Major facilitator Superfamily
AS53_5178	COG1556	Lactate utilization protein
AS53_5179	COG1139	Iron-sulfur cluster binding protein
AS53_5181	COG0583	DNA-binding transcription factor activity
AS53_5183	COG1619	proteins homologs of microcin C7 resistance protein MccF
AS53_5187	COG0738	Major facilitator superfamily
AS53_5188	COG0673	inositol 2-dehydrogenase activity
AS53_5189	COG0561	phosphatase activity
AS53_5190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AS53_5191	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AS53_5192	COG1609	Transcriptional regulator
AS53_5193	COG0457	Tetratricopeptide repeat
AS53_5197	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS53_520	COG2084	Dehydrogenase
AS53_5204	COG0534	Mate efflux family protein
AS53_5207	COG2184	nucleotidyltransferase activity
AS53_5208	COG2814	Major facilitator Superfamily
AS53_5209	COG1309	transcriptional regulator
AS53_521	COG2084	Dehydrogenase
AS53_5212	COG0814	amino acid
AS53_5213	COG1760	l-serine dehydratase
AS53_5214	COG1760	l-serine dehydratase
AS53_5215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AS53_5216	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AS53_5218	COG1335	isochorismatase
AS53_5219	COG1522	sequence-specific DNA binding
AS53_522	COG3706	GGDEF domain
AS53_5220	COG0531	amino acid
AS53_5223	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS53_5227	COG1595	DNA-templated transcription, initiation
AS53_523	COG0778	Nitroreductase
AS53_5230	COG0662	Cupin 2, conserved barrel domain protein
AS53_5231	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_5231	COG2207	Transcriptional regulator
AS53_5242	COG0477	Major facilitator Superfamily
AS53_5244	COG1846	Transcriptional regulator
AS53_5245	COG2814	Major facilitator Superfamily
AS53_5248	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AS53_5249	COG1131	(ABC) transporter
AS53_5253	COG2076	Multidrug Resistance protein
AS53_5254	COG1309	transcriptional regulator
AS53_5256	COG2031	fatty acid transporter
AS53_5258	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS53_5264	COG1122	ATPase activity
AS53_5265	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AS53_5268	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AS53_5269	COG1288	antiporter activity
AS53_5270	COG2356	endonuclease I
AS53_5273	COG3620	sequence-specific DNA binding
AS53_5274	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AS53_5275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AS53_5276	COG0124	histidyl-tRNA synthetase
AS53_5279	COG1733	regulation of RNA biosynthetic process
AS53_528	COG1263	PTS System
AS53_528	COG2190	(PTS) system
AS53_528	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS53_5280	COG0778	Nitroreductase
AS53_5284	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_5286	COG1131	(ABC) transporter
AS53_529	COG3711	transcriptional antiterminator
AS53_5291	COG1011	Hydrolase
AS53_5298	COG0346	lactoylglutathione lyase activity
AS53_5299	COG1940	carbohydrate kinase activity
AS53_5300	COG0738	Major facilitator superfamily
AS53_5301	COG0110	maltose O-acetyltransferase activity
AS53_5303	COG1136	(ABC) transporter
AS53_5305	COG0180	Tryptophanyl-tRNA synthetase
AS53_5306	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AS53_5307	COG0628	permease
AS53_5311	COG2226	methyltransferase
AS53_5313	COG0477	Major facilitator Superfamily
AS53_5319	COG1253	flavin adenine dinucleotide binding
AS53_5320	COG0789	Transcriptional regulator
AS53_5321	COG0697	spore germination
AS53_5322	COG1357	PFAM Pentapeptide repeats (8 copies)
AS53_5323	COG3813	Protein conserved in bacteria
AS53_5324	COG2706	6-phosphogluconolactonase activity
AS53_5325	COG1070	Carbohydrate kinase
AS53_5327	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AS53_5328	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AS53_533	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AS53_5330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AS53_5331	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AS53_5332	COG0604	alcohol dehydrogenase
AS53_5333	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS53_5336	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_5341	COG0656	L-ascorbic acid biosynthetic process
AS53_5342	COG2814	Major facilitator Superfamily
AS53_5345	COG0346	lactoylglutathione lyase activity
AS53_5346	COG0814	amino acid
AS53_5351	COG1393	Belongs to the ArsC family
AS53_5352	COG1733	regulation of RNA biosynthetic process
AS53_5353	COG2188	Transcriptional regulator
AS53_5354	COG0673	inositol 2-dehydrogenase activity
AS53_5356	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AS53_5357	COG1733	regulation of RNA biosynthetic process
AS53_5358	COG1733	regulation of RNA biosynthetic process
AS53_5361	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_5365	COG0384	phenazine biosynthesis protein PhzF
AS53_5367	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_5369	COG0318	PFAM AMP-dependent synthetase and ligase
AS53_5371	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS53_5372	COG1733	regulation of RNA biosynthetic process
AS53_5376	COG0726	polysaccharide deacetylase
AS53_5379	COG1191	sigma factor activity
AS53_538	COG1547	Domain of unknown function (DUF309)
AS53_5382	COG1309	transcriptional regulator
AS53_5386	COG3152	Membrane
AS53_539	COG0456	acetyltransferase
AS53_5391	COG1151	hydroxylamine reductase activity
AS53_5394	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_5395	COG3409	Peptidoglycan-binding domain 1 protein
AS53_5395	COG3757	hydrolase, family 25
AS53_540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AS53_5402	COG2072	flavoprotein involved in K transport
AS53_5409	COG0604	alcohol dehydrogenase
AS53_541	COG4086	secreted protein
AS53_5410	COG1113	amino acid transport
AS53_5411	COG2814	Major facilitator Superfamily
AS53_5417	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS53_5418	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AS53_542	COG0561	phosphatase activity
AS53_5422	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_5424	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_5425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_5426	COG3739	integral membrane protein
AS53_5427	COG0384	phenazine biosynthesis protein PhzF
AS53_543	COG0697	spore germination
AS53_5433	COG0583	DNA-binding transcription factor activity
AS53_5437	COG1193	negative regulation of DNA recombination
AS53_5440	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AS53_5443	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AS53_5449	COG0584	glycerophosphoryl diester phosphodiesterase
AS53_5453	COG0640	Transcriptional regulator
AS53_5454	COG0604	alcohol dehydrogenase
AS53_5456	COG0457	Tetratricopeptide repeat
AS53_5459	COG2808	Putative FMN-binding domain
AS53_546	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS53_5460	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS53_5462	COG0385	Bile acid
AS53_5463	COG0277	FAD linked oxidase domain protein
AS53_5471	COG1024	Enoyl-CoA hydratase
AS53_5473	COG1285	pathogenesis
AS53_5475	COG2514	catechol 2,3-dioxygenase activity
AS53_5476	COG2720	vancomycin resistance protein
AS53_5482	COG1278	Cold shock
AS53_5484	COG0716	FMN binding
AS53_5490	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_5492	COG0165	Argininosuccinate lyase
AS53_5495	COG4145	pantothenate transmembrane transporter activity
AS53_5496	COG3924	membrane
AS53_5497	COG1012	belongs to the aldehyde dehydrogenase family
AS53_5498	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_5500	COG1657	PFAM Prenyltransferase squalene oxidase
AS53_5501	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AS53_5502	COG2962	Rard protein
AS53_5503	COG3326	Membrane
AS53_5506	COG0489	protein tyrosine kinase activity
AS53_5508	COG0314	molybdopterin synthase activity
AS53_5509	COG0303	'Molybdopterin
AS53_551	COG0733	neurotransmitter:sodium symporter activity
AS53_5510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS53_5511	COG2116	formate transmembrane transporter activity
AS53_5513	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AS53_5514	COG5609	conserved protein (DUF2294)
AS53_5515	COG2427	Protein of unknown function (DUF1641)
AS53_5516	COG3383	formate dehydrogenase (NAD+) activity
AS53_5517	COG3383	formate dehydrogenase (NAD+) activity
AS53_5519	COG0697	spore germination
AS53_5527	COG2226	methyltransferase
AS53_5528	COG4166	transmembrane transport
AS53_5529	COG4166	transmembrane transport
AS53_5530	COG4166	transmembrane transport
AS53_5531	COG1301	dicarboxylic acid transport
AS53_5532	COG1316	TRANSCRIPTIONal
AS53_5534	COG1595	DNA-templated transcription, initiation
AS53_5538	COG1131	(ABC) transporter
AS53_5540	COG0673	inositol 2-dehydrogenase activity
AS53_5541	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AS53_5542	COG0187	DNA topoisomerase II activity
AS53_5543	COG1832	CoA-binding protein
AS53_5544	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS53_5545	COG0745	RESPONSE REGULATOR receiver
AS53_5548	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AS53_5549	COG4841	protein insertion into membrane
AS53_555	COG1686	Belongs to the peptidase S11 family
AS53_5550	COG0824	Thioesterase
AS53_5556	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS53_5558	COG2274	protein secretion by the type I secretion system
AS53_5559	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AS53_556	COG1725	Transcriptional regulator
AS53_5561	COG0726	polysaccharide deacetylase
AS53_5564	COG2211	Major facilitator Superfamily
AS53_5566	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AS53_5569	COG0183	Belongs to the thiolase family
AS53_557	COG1131	(ABC) transporter
AS53_5570	COG0318	PFAM AMP-dependent synthetase and ligase
AS53_5571	COG1268	BioY protein
AS53_5572	COG0318	PFAM AMP-dependent synthetase and ligase
AS53_5581	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_5583	COG5002	protein histidine kinase activity
AS53_5584	COG0400	carboxylic ester hydrolase activity
AS53_5585	COG0346	lactoylglutathione lyase activity
AS53_5586	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS53_5587	COG0069	glutamate synthase activity
AS53_5588	COG1902	pentaerythritol trinitrate reductase activity
AS53_5589	COG1329	Transcriptional regulator
AS53_5590	COG0010	Belongs to the arginase family
AS53_5595	COG2226	methyltransferase
AS53_560	COG1846	Transcriptional regulator
AS53_5613	COG1923	regulation of RNA biosynthetic process
AS53_5615	COG0457	Tetratricopeptide repeat
AS53_5620	COG4974	Belongs to the 'phage' integrase family
AS53_5622	COG3443	Belongs to the bacterial solute-binding protein 9 family
AS53_5624	COG2801	Transposase and inactivated derivatives
AS53_5626	COG2801	Transposase and inactivated derivatives
AS53_5629	COG2801	Transposase and inactivated derivatives
AS53_563	COG0598	Magnesium transport protein CorA
AS53_5630	COG2801	Transposase and inactivated derivatives
AS53_5639	COG4974	Belongs to the 'phage' integrase family
AS53_5641	COG2002	toxin-antitoxin pair type II binding
AS53_5677	COG2801	Transposase and inactivated derivatives
AS53_568	COG4974	Belongs to the 'phage' integrase family
AS53_5683	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AS53_5684	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS53_5688	COG0671	phosphoesterase, PA-phosphatase related
AS53_5689	COG4196	transglutaminase domain protein
AS53_5695	COG2311	Membrane
AS53_570	COG0735	belongs to the Fur family
AS53_571	COG1300	Membrane
AS53_5726	COG4962	Type ii secretion system protein e
AS53_575	COG0667	Aldo Keto reductase
AS53_576	COG0656	L-ascorbic acid biosynthetic process
AS53_577	COG0456	acetyltransferase
AS53_577	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS53_5773	COG3344	reverse transcriptase
AS53_579	COG0737	Belongs to the 5'-nucleotidase family
AS53_579	COG4085	toxin activity
AS53_579	COG1525	nuclease
AS53_5794	COG3344	reverse transcriptase
AS53_581	COG0596	Alpha beta hydrolase
AS53_582	COG2056	Na+-H+ antiporter family
AS53_5820	COG0741	lytic transglycosylase activity
AS53_5820	COG0791	NLP P60 protein
AS53_585	COG0456	acetyltransferase
AS53_5854	COG1192	Involved in chromosome partitioning
AS53_5859	COG2801	Transposase and inactivated derivatives
AS53_586	COG1073	alpha beta
AS53_5866	COG1683	Conserved Protein
AS53_5867	COG1309	transcriptional regulator
AS53_5884	COG0681	Belongs to the peptidase S26 family
AS53_589	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS53_589	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS53_5891	COG1280	lysine exporter protein (LysE YggA)
AS53_5897	COG4166	transmembrane transport
AS53_590	COG0307	riboflavin synthase, alpha
AS53_5901	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS53_5911	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AS53_5912	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AS53_5912	COG0551	DNA topoisomerase type I activity
AS53_594	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AS53_595	COG4106	trans-aconitate 2-methyltransferase activity
AS53_596	COG2226	methyltransferase
AS53_596	COG1073	alpha beta
AS53_597	COG0156	8-amino-7-oxononanoate synthase activity
AS53_599	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS53_6	COG1380	Effector of murein hydrolase LrgA
AS53_602	COG0737	Belongs to the 5'-nucleotidase family
AS53_604	COG1522	sequence-specific DNA binding
AS53_608	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AS53_610	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AS53_613	COG0300	oxidoreductase activity
AS53_614	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_616	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS53_617	COG1760	l-serine dehydratase
AS53_618	COG1760	l-serine dehydratase
AS53_621	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS53_623	COG2195	Cleaves the N-terminal amino acid of tripeptides
AS53_624	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_626	COG1376	ErfK ybiS ycfS ynhG family protein
AS53_627	COG4129	membrane
AS53_628	COG1126	abc transporter atp-binding protein
AS53_629	COG0765	amino acid transport
AS53_630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS53_633	COG2816	NAD+ diphosphatase activity
AS53_634	COG0772	Belongs to the SEDS family
AS53_635	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS53_636	COG0022	dehydrogenase e1 component
AS53_637	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AS53_638	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS53_640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AS53_641	COG0280	phosphate acetyltransferase
AS53_642	COG3290	protein histidine kinase activity
AS53_642	COG3829	transcription factor binding
AS53_644	COG0584	glycerophosphoryl diester phosphodiesterase
AS53_645	COG3093	addiction module antidote protein HigA
AS53_647	COG0745	RESPONSE REGULATOR receiver
AS53_648	COG0750	zinc metalloprotease
AS53_649	COG0497	DNA recombination
AS53_651	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AS53_653	COG0142	geranyltranstransferase activity
AS53_658	COG1302	Protein conserved in bacteria
AS53_659	COG0439	Biotin carboxylase
AS53_660	COG0511	ligase activity, forming carbon-carbon bonds
AS53_669	COG3854	ATPases associated with a variety of cellular activities
AS53_674	COG0006	proline dipeptidase activity
AS53_677	COG3872	metal-dependent enzyme
AS53_678	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS53_683	COG0095	Lipoate-protein ligase
AS53_684	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS53_685	COG1609	Transcriptional regulator
AS53_687	COG2076	Multidrug Resistance protein
AS53_688	COG2076	Multidrug Resistance protein
AS53_695	COG1131	(ABC) transporter
AS53_696	COG1725	Transcriptional regulator
AS53_7	COG1346	cytolysis
AS53_702	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS53_713	COG4970	Tfp pilus assembly protein FimT
AS53_715	COG1459	type II secretion system
AS53_716	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AS53_726	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AS53_727	COG1410	methionine synthase
AS53_727	COG0646	methionine synthase
AS53_728	COG0646	methionine synthase
AS53_728	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AS53_729	COG0626	cystathionine gamma-synthase activity
AS53_730	COG0626	cystathionine gamma-synthase activity
AS53_734	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_736	COG1940	carbohydrate kinase activity
AS53_737	COG4483	Protein conserved in bacteria
AS53_738	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AS53_740	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AS53_741	COG0704	Plays a role in the regulation of phosphate uptake
AS53_742	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AS53_743	COG0581	inorganic phosphate transmembrane transporter activity
AS53_744	COG0573	inorganic phosphate transmembrane transporter activity
AS53_745	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AS53_747	COG0477	Major facilitator Superfamily
AS53_748	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AS53_753	COG0735	belongs to the Fur family
AS53_754	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AS53_755	COG1121	(ABC) transporter
AS53_756	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_762	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AS53_763	COG2384	SAM-dependent methyltransferase
AS53_764	COG2010	Cytochrome c
AS53_765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AS53_766	COG0358	DNA primase activity
AS53_768	COG0517	IMP dehydrogenase activity
AS53_771	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AS53_772	COG0295	cytidine deaminase activity
AS53_773	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AS53_775	COG1480	7TM receptor with intracellular HD hydrolase
AS53_776	COG1702	phosphate starvation-inducible protein PhoH
AS53_779	COG1610	YqeY-like protein
AS53_781	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AS53_782	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AS53_786	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AS53_788	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS53_789	COG1733	regulation of RNA biosynthetic process
AS53_794	COG1466	dna polymerase III delta subunit
AS53_796	COG2333	competence protein COMEC
AS53_796	COG0658	competence protein
AS53_797	COG2131	deaminase
AS53_798	COG1596	polysaccharide export
AS53_798	COG1555	photosystem II stabilization
AS53_799	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS53_800	COG2226	methyltransferase
AS53_801	COG0799	negative regulation of ribosome biogenesis
AS53_802	COG1713	HD superfamily hydrolase involved in NAD metabolism
AS53_804	COG1534	Rna-binding protein
AS53_806	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AS53_807	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AS53_809	COG1191	sigma factor activity
AS53_812	COG1595	DNA-templated transcription, initiation
AS53_814	COG0778	Nitroreductase
AS53_815	COG2357	RelA SpoT domain protein
AS53_817	COG1785	Belongs to the alkaline phosphatase family
AS53_819	COG2267	carboxylic ester hydrolase activity
AS53_82	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AS53_826	COG1404	Belongs to the peptidase S8 family
AS53_827	COG3186	Phenylalanine-4-hydroxylase
AS53_829	COG2514	catechol 2,3-dioxygenase activity
AS53_830	COG2514	catechol 2,3-dioxygenase activity
AS53_831	COG2259	Doxx family
AS53_839	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_841	COG1012	belongs to the aldehyde dehydrogenase family
AS53_841	COG1454	alcohol dehydrogenase
AS53_842	COG0626	cystathionine gamma-synthase activity
AS53_843	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS53_848	COG0768	penicillin binding
AS53_854	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AS53_858	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AS53_860	COG0628	permease
AS53_864	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AS53_866	COG0482	sulfurtransferase activity
AS53_867	COG1104	cysteine desulfurase activity
AS53_868	COG1959	2 iron, 2 sulfur cluster binding
AS53_869	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AS53_871	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AS53_873	COG0124	histidyl-tRNA synthetase
AS53_876	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS53_878	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AS53_878	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AS53_879	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AS53_880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS53_880	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS53_882	COG2244	polysaccharide biosynthetic process
AS53_883	COG2323	membrane
AS53_885	COG1862	Preprotein translocase
AS53_891	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AS53_893	COG0697	spore germination
AS53_894	COG0697	spore germination
AS53_895	COG0640	Transcriptional regulator
AS53_900	COG0157	Belongs to the NadC ModD family
AS53_901	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AS53_902	COG1104	cysteine desulfurase activity
AS53_903	COG1827	regulation of RNA biosynthetic process
AS53_904	COG2258	MOSC domain
AS53_905	COG0077	Prephenate dehydratase
AS53_906	COG0577	efflux transmembrane transporter activity
AS53_907	COG0577	efflux transmembrane transporter activity
AS53_908	COG1136	(ABC) transporter
AS53_909	COG5002	protein histidine kinase activity
AS53_911	COG0745	RESPONSE REGULATOR receiver
AS53_912	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AS53_913	COG3290	protein histidine kinase activity
AS53_915	COG2868	ribosomal protein
AS53_917	COG1530	ribonuclease E activity
AS53_918	COG1994	Peptidase M50
AS53_919	COG0739	heme binding
AS53_920	COG2894	cell division
AS53_923	COG1792	Involved in formation and maintenance of cell shape
AS53_924	COG1077	Cell shape determining protein MreB Mrl
AS53_928	COG0285	dihydrofolate synthase activity
AS53_929	COG0525	valine-tRNA ligase activity
AS53_931	COG1388	LysM domain
AS53_933	COG0113	porphobilinogen synthase activity
AS53_934	COG1587	Uroporphyrinogen-III synthase
AS53_936	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AS53_938	COG1846	Transcriptional regulator
AS53_939	COG1764	response to oxidative stress
AS53_942	COG0470	DNA polymerase III
AS53_942	COG1067	ATP-dependent peptidase activity
AS53_952	COG0622	Phosphoesterase
AS53_953	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AS53_955	COG5401	PFAM Sporulation and spore germination
AS53_959	COG1309	transcriptional regulator
AS53_962	COG2197	response regulator
AS53_963	COG2233	PERMEase
AS53_965	COG0402	S-adenosylhomocysteine deaminase activity
AS53_966	COG0402	S-adenosylhomocysteine deaminase activity
AS53_970	COG0444	Belongs to the ABC transporter superfamily
AS53_971	COG4608	Belongs to the ABC transporter superfamily
AS53_972	COG3275	phosphorelay sensor kinase activity
AS53_973	COG3279	Response regulator of the LytR AlgR family
AS53_976	COG1983	PspC domain protein
AS53_977	COG1396	sequence-specific DNA binding
AS53_978	COG0697	spore germination
AS53_98	COG1396	sequence-specific DNA binding
AS53_980	COG1959	2 iron, 2 sulfur cluster binding
AS53_981	COG1668	transmembrane transport
AS53_982	COG4152	abc transporter atp-binding protein
AS53_983	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AS53_984	COG1360	Flagellar Motor Protein
AS53_985	COG1360	Flagellar Motor Protein
AS53_986	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AS53_987	COG1876	peptidase activity
AS53_988	COG0824	Thioesterase
AS53_989	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AS53_990	COG1053	succinate dehydrogenase
AS53_991	COG2009	succinate dehydrogenase
AS53_992	COG1719	4-vinyl reductase, 4VR
AS53_994	COG3118	belongs to the thioredoxin family
AS53_995	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AS53_996	COG2086	electron transfer activity
AS53_997	COG1024	Enoyl-CoA hydratase
AS53_998	COG1309	transcriptional regulator
AS53_999	COG0318	PFAM AMP-dependent synthetase and ligase