locus-tag class description AK39_10 ENOG4105EFC phage portal protein HK97 family AK39_1000 ENOG4105DFD Na H antiporter AK39_1002 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AK39_1004 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AK39_1005 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AK39_1006 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AK39_1007 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AK39_101 ENOG4107R7I amino acid AK39_1011 ENOG4108R6K riboflavin synthase, subunit alpha AK39_1012 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AK39_1016 ENOG4108YM7 Gcn5-related n-acetyltransferase AK39_1017 ENOG4105ETE Transcriptional regulator (LacI family AK39_1019 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AK39_102 ENOG4108SUT Major Facilitator Superfamily AK39_1023 ENOG4105RHY Pfam:UPF0157 AK39_1025 ENOG4105CPC Aldo Keto reductase AK39_1029 ENOG4105MZ9 stage II sporulation protein m AK39_1030 ENOG4105I3K Ferric uptake regulator, Fur family AK39_1032 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AK39_1037 ENOG4105D7N magnesium and cobalt transport protein CorA AK39_1043 ENOG4105DVE abc transporter atp-binding protein AK39_1044 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AK39_1045 ENOG4105DZ1 carboxypeptidase AK39_1046 ENOG41082AN stage II sporulation protein AK39_1048 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK39_1049 ENOG4105C8J )-transporter AK39_1053 ENOG41090VF Stage v sporulation protein ac AK39_1054 ENOG4105CZ3 stage V sporulation protein ad AK39_1056 ENOG4105G6R Stage v sporulation protein ae AK39_1058 ENOG4105J7I hydrolase AK39_1059 ENOG4105PTM secreted protein AK39_106 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AK39_1060 ENOG4107ZE5 PPIases accelerate the folding of proteins AK39_1067 ENOG4105CE4 GlcNAc 6-P deacetylase AK39_1069 ENOG4105FDP GntR family transcriptional regulator AK39_1071 ENOG4105CID antiterminator AK39_1074 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AK39_1078 ENOG4106TD9 Diguanylate cyclase AK39_1079 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AK39_1080 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AK39_1083 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AK39_1088 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AK39_1090 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AK39_1092 ENOG4105DTD Dehydrogenase AK39_1093 ENOG4105K7K Transcriptional regulator AK39_110 ENOG4105DZ1 carboxypeptidase AK39_1100 ENOG4105CHU acetyl-coa acetyltransferase AK39_1109 ENOG4105CG3 alpha amylase, catalytic region AK39_1111 ENOG4107FKK extracellular solute-binding protein family 1 AK39_1113 ENOG4105EG2 ABC transporter, permease AK39_1114 ENOG4105FKQ transcriptional regulator AK39_1115 ENOG4105CHM Aminotransferase AK39_1117 ENOG4108HGU Histidine kinase AK39_1128 ENOG4105UIN AK39_113 ENOG4105CHU acetyl-coa acetyltransferase AK39_1130 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AK39_1133 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AK39_1134 ENOG4105EPM Diguanylate phosphodiesterase AK39_1137 ENOG4107IN1 Protein of unknown function (DUF1797) AK39_1139 ENOG4108XRC Protein of unknown function (DUF458) AK39_114 ENOG4105C1G acyl-Coa dehydrogenase AK39_1146 ENOG4107ZYR domain protein AK39_1147 ENOG4105CN5 Metallo-Beta-Lactamase AK39_1149 ENOG4108X4Q Hydrolase AK39_115 ENOG4108W8B Beta-lactamase domain protein AK39_1150 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AK39_1153 ENOG4105CPP Dehydrogenase, E1 component AK39_1154 ENOG4105C7S Dehydrogenase AK39_1163 ENOG4105CXN decarboxylase AK39_1167 ENOG4105ECY inositol monophosphatase AK39_1169 ENOG4105CI3 gtp-binding protein typa AK39_1170 ENOG4105QA2 AK39_1174 ENOG4108IAB Phoh family AK39_1177 ENOG4105CNI cell division protein FtsW AK39_1178 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AK39_1188 ENOG4106UY4 Inherit from COG: Scp-like extracellular AK39_1191 ENOG4107TB6 phosphoglycerate mutase AK39_1196 ENOG4106H78 methyltransferase AK39_1197 ENOG4105H20 Sporulation integral membrane protein YlbJ AK39_1199 ENOG4105D78 K07001 NTE family protein AK39_1200 ENOG41063PX domain protein AK39_1202 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) AK39_121 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AK39_1210 ENOG4108IMY Transcriptional regulator AK39_1221 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK39_1224 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AK39_1241 ENOG4105CAR Terminase, large subunit AK39_1243 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AK39_1260 ENOG4105XSJ toxin secretion phage lysis holin AK39_1270 ENOG4105KNH Nucleic acid-binding protein AK39_1277 ENOG41068DC Essential cell division protein (By similarity) AK39_1278 ENOG4105CJN penicillin-binding protein AK39_1279 ENOG4105CJN penicillin-binding protein AK39_1280 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AK39_1283 ENOG4105CNI cell division protein FtsW AK39_1284 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AK39_1285 ENOG4105D4A Cell wall formation (By similarity) AK39_1286 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AK39_1287 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AK39_1288 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AK39_1290 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK39_1292 ENOG4105WR5 sporulation protein, YlmC YmxH family AK39_1293 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AK39_1294 ENOG4105DFA alanine racemase domain protein AK39_1296 ENOG41067XK integral membrane protein AK39_1297 ENOG4105DBK s4 domain protein AK39_1299 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AK39_130 ENOG41080E8 Transcriptional regulator, Spx MgsR family AK39_1302 ENOG4105C34 Pseudouridine synthase AK39_1307 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AK39_1318 ENOG4105DC7 peptidase M24 AK39_1319 ENOG4105F23 Fibronectin-binding protein AK39_1321 ENOG4105DSJ YicC domain protein AK39_1325 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AK39_1326 ENOG4105C25 Primosomal protein n' AK39_1327 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AK39_1329 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AK39_1331 ENOG4108ZF3 Phosphatase AK39_1332 ENOG4105D9P serine threonine protein kinase AK39_1333 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AK39_1334 ENOG4105DJV ribulose-phosphate 3-epimerase AK39_1335 ENOG4105FJ0 thiamine AK39_1337 ENOG4108ZAA Alkaline-shock protein AK39_1338 ENOG4105DP4 dak2 domain fusion protein ylov AK39_1339 ENOG4105CB5 ATP-dependent DNA helicase recG AK39_1342 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AK39_1343 ENOG4105CHR reductase AK39_1346 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AK39_1347 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AK39_1351 ENOG4105VB6 UPF0109 protein AK39_1356 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AK39_1359 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AK39_136 ENOG4108UMI ABC transporter, permease AK39_1361 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AK39_1363 ENOG4108HE4 integrase family AK39_137 ENOG4105D01 (LipO)protein AK39_1371 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AK39_1372 ENOG4105KNE Phosphatidate cytidylyltransferase AK39_1373 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AK39_1374 ENOG4105DZP Membrane-associated zinc metalloprotease AK39_1376 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AK39_1378 ENOG4105CHV Transcription elongation factor NusA AK39_1379 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AK39_138 ENOG4105D01 (LipO)protein AK39_1380 ENOG4105VHM ribosomal protein AK39_1382 ENOG4105W7A Protein of unknown function (DUF503) AK39_1384 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AK39_1385 ENOG4105DTN riboflavin biosynthesis protein ribF AK39_1389 ENOG4105C1V Peptidase, M16 AK39_139 ENOG4105C3K feS assembly ATPase SufC AK39_1391 ENOG4105E35 Dipicolinate synthase subunit A AK39_1392 ENOG4108S0H Dipicolinic acid synthetase, b subunit AK39_1393 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AK39_1395 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AK39_1397 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AK39_1399 ENOG4107QZI cell division protein FtsK AK39_140 ENOG4105JRK feS assembly protein SufD AK39_1400 ENOG4105FDP GntR family transcriptional regulator AK39_1401 ENOG4105DIH basic membrane AK39_1402 ENOG4108JQ9 ABC transporter AK39_1403 ENOG4105UIB (ABC) transporter AK39_1404 ENOG4105UIB (ABC) transporter AK39_1408 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AK39_1409 ENOG4105XZV Protein of unknown function (DUF3243) AK39_141 ENOG4105C9B Cysteine desulfurase AK39_1412 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AK39_1417 ENOG4105D48 metallophosphoesterase AK39_1418 ENOG4105MCT stage V sporulation protein S AK39_1419 ENOG4108IGT Dipeptidase AK39_142 ENOG4108UNV SUF system FeS assembly protein, NifU family AK39_1420 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AK39_1421 ENOG4105DQU oxidoreductase, subunit beta AK39_1422 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AK39_1427 ENOG4105DA5 (ABC) transporter AK39_143 ENOG4105DIW FeS assembly protein SUFB AK39_1432 ENOG4107QHE Choloylglycine hydrolase AK39_1434 ENOG410890F Dynamin family AK39_1435 ENOG4105E0M Sulfatase AK39_1436 ENOG4107R6R udp-galactopyranose mutase AK39_1437 ENOG4105F0V Cell wall hydrolase AK39_1441 ENOG4107YEI lmbE family AK39_1442 ENOG4107TTQ Alpha beta hydrolase fold AK39_1445 ENOG41067MG lrgb family AK39_1448 ENOG4105BZU Histidine kinase AK39_1449 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AK39_1455 ENOG4105D03 DNA-3-methyladenine glycosylase II AK39_1456 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AK39_1458 ENOG4105CGK Exodeoxyribonuclease III AK39_146 ENOG4107R8B 5'-nucleotidase AK39_1463 ENOG4105E0A ABC, transporter AK39_1464 ENOG4105NIV Esterase AK39_1466 ENOG4105VPX protein, conserved in bacteria AK39_1467 ENOG410681U heavy metal transport detoxification protein AK39_1468 ENOG4105C59 p-type ATPase AK39_1469 ENOG4105K70 DNA-binding protein AK39_147 ENOG4105KZD Domain of unknown function (DUF1805) AK39_1470 ENOG4105TMB Formate nitrite transporter AK39_1474 ENOG4105C85 amino acid AK39_1477 ENOG4108SJC Membrane AK39_1478 ENOG4107QW4 alcohol dehydrogenase AK39_1479 ENOG4107QW4 alcohol dehydrogenase AK39_1480 ENOG4105E98 transcriptional regulator DeoR family AK39_1481 ENOG4105DE4 1-phosphofructokinase AK39_1482 ENOG4105DM4 PTS System AK39_1483 ENOG41069ER domain protein AK39_149 ENOG4105FAA peptidase M23 AK39_1490 ENOG4106F1P AAA ATPase, central domain protein AK39_1491 ENOG4105EN6 Membrane AK39_1492 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AK39_1493 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AK39_1494 ENOG4105CXI aluminum resistance protein AK39_1495 ENOG4105KV4 Transcriptional regulator AK39_1496 ENOG4105C5F glutamine synthetase AK39_1517 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) AK39_154 ENOG41090T1 Membrane AK39_155 ENOG4107TXC Transcriptional regulator AK39_1557 ENOG4105XSJ toxin secretion phage lysis holin AK39_1558 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AK39_156 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AK39_1566 ENOG4105K7K Transcriptional regulator AK39_157 ENOG4105MMD transcriptional regulator AK39_1570 ENOG4108SVB resolvase AK39_1572 ENOG4105CGH 5'-nucleotidase AK39_1575 ENOG4105D5T phosphonate abc transporter AK39_1578 ENOG4105D7V transposase AK39_1582 ENOG4105BZ1 (ABC) transporter AK39_1583 ENOG4105BZ1 (ABC) transporter AK39_1586 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AK39_1591 ENOG41067MG lrgb family AK39_1592 ENOG4105VAW lrga family AK39_1593 ENOG4107RSM transcriptional regulator AK39_1595 ENOG4107QIV Cytochrome c biogenesis protein AK39_160 ENOG4105CBT Fructose-1,6-bisphosphatase AK39_1606 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AK39_1611 ENOG4108903 Formimidoylglutamase AK39_1612 ENOG4108VJ1 Transcriptional regulator (CarD family AK39_1613 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AK39_1614 ENOG4105CBC glutamate synthase AK39_1615 ENOG4105CK7 Sodium proline symporter AK39_1616 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AK39_1617 ENOG4105FBA Phospholipase Carboxylesterase AK39_1618 ENOG4105BZU Histidine kinase AK39_1620 ENOG4107AYK membrAne AK39_1629 ENOG4105CEY Amp-dependent synthetase and ligase AK39_163 ENOG4105D4U had-superfamily hydrolase, subfamily iia AK39_1630 ENOG4107ZYJ bioY protein AK39_1631 ENOG4107F3J Amp-dependent synthetase and ligase AK39_1635 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AK39_1637 ENOG4105E5W Transporter AK39_164 ENOG4105DYS nad(p)h dehydrogenase (quinone) AK39_1642 ENOG4108I0Z Aconitate hydratase AK39_1643 ENOG4108JJA ABC, transporter AK39_1645 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AK39_1646 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AK39_1652 ENOG4105W8X HesB YadR YfhF-family protein AK39_1653 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AK39_1654 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AK39_1656 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK39_1657 ENOG4105C0H protease AK39_1658 ENOG4105K4P CoA-binding domain protein AK39_1659 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AK39_166 ENOG4108W5N phosphatidylglycerophosphatase a AK39_1661 ENOG4105D9R oxidoreductase AK39_1663 ENOG4105CIG ABC transporter AK39_1667 ENOG4105EMN RNA polymerase sigma factor AK39_1669 ENOG4108KGH TRANSCRIPTIONal AK39_1670 ENOG4107QJT sodium dicarboxylate symporter AK39_1682 ENOG4105E1K spore germination protein AK39_1684 ENOG4108JB9 formate dehydrogenase AK39_1686 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AK39_1687 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AK39_1689 ENOG4105TMB Formate nitrite transporter AK39_169 ENOG41083MR nifu domain-containing protein AK39_1690 ENOG4105D06 uba thif-type nad fad binding protein AK39_1691 ENOG4105CVM Molybdenum cofactor synthesis domain protein AK39_1692 ENOG4108ZAF Molybdopterin AK39_1694 ENOG4105D1F ATP-binding protein AK39_1697 ENOG410696E Membrane AK39_1698 ENOG4105FR1 rard protein AK39_1700 ENOG4105EWU Squalene--hopene cyclase AK39_1702 ENOG4105CHR reductase AK39_1703 ENOG4105C26 Dehydrogenase AK39_1705 ENOG4108IA2 Sodium pantothenate symporter AK39_1708 ENOG4106IQC argininosuccinate lyase AK39_1710 ENOG410904N short-chain dehydrogenase reductase AK39_1714 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AK39_1718 ENOG4105VEQ Cold shock protein AK39_1722 ENOG4108R1P AK39_1724 ENOG41073R8 VanW family AK39_1725 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AK39_1727 ENOG4105KT7 mgtC SapB transporter AK39_1729 ENOG4105E39 Enoyl-CoA hydratase AK39_1730 ENOG4105K64 Glycosyl transferase, family 2 AK39_1732 ENOG4108UT6 Transferase hexapeptide repeat containing protein AK39_1736 ENOG4105CQB FAD linked oxidase domain protein AK39_1737 ENOG4105C09 Bile acid AK39_1739 ENOG4105RHY Pfam:UPF0157 AK39_1745 ENOG4105CIS alcohol dehydrogenase AK39_1746 ENOG41082BM Transcriptional regulator, arsr family AK39_1750 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AK39_1756 ENOG4108A04 Beta-lactamase AK39_1757 ENOG4105DPN Oligoendopeptidase f AK39_1758 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AK39_1759 ENOG4105E5K Alpha-amylase AK39_1761 ENOG4105C98 muts2 protein AK39_1765 ENOG4107V2S Transcriptional regulator AK39_1767 ENOG4107CUJ Protein of unknown function (DUF2690) AK39_1771 ENOG4107ZY0 Phenazine biosynthesis-like protein AK39_1772 ENOG4105NX3 Membrane AK39_1773 ENOG4105DQ5 transport system permease protein AK39_1774 ENOG4105EHG Permease protein AK39_1776 ENOG4108MES Periplasmic binding protein AK39_178 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AK39_1780 ENOG4107R3E Citrate transporter AK39_1782 ENOG4108TN2 lmbE family AK39_1789 ENOG4105CIS alcohol dehydrogenase AK39_179 ENOG4105C4B ABC transporter, permease AK39_1796 ENOG4105H3G oxidoreductase AK39_1798 ENOG4105ED2 Beta-lactamase AK39_180 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AK39_1803 ENOG4107YXZ hydrolase, family 25 AK39_1807 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AK39_1812 ENOG4105KAF membrAne AK39_1822 ENOG4108ZJ4 polysaccharide deacetylase AK39_1826 ENOG4105KVH Transcriptional regulator AK39_1827 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AK39_1831 ENOG4105CHR reductase AK39_1833 ENOG4105JAB phenazine biosynthesis protein, phzf family AK39_184 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AK39_1840 ENOG4105KVH Transcriptional regulator AK39_1841 ENOG4105KVH Transcriptional regulator AK39_1842 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AK39_1844 ENOG4105D9R oxidoreductase AK39_1845 ENOG4108TZY GntR Family Transcriptional Regulator AK39_1846 ENOG4105KVH Transcriptional regulator AK39_1852 ENOG4105C44 Serine transporter AK39_1853 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AK39_1856 ENOG4105F27 Major Facilitator AK39_1857 ENOG4105CV8 reductase AK39_1861 ENOG4105D4Y metalloprotease AK39_1862 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AK39_1865 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AK39_1866 ENOG4105CIS alcohol dehydrogenase AK39_1867 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AK39_1868 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AK39_187 ENOG4105EWC Purine nucleoside phosphorylase AK39_1871 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AK39_1872 ENOG4105C6Z Gluconate AK39_1873 ENOG4105CMG Carbohydrate kinase AK39_1874 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AK39_1875 ENOG4105XDF Protein of unknown function (DUF1272) AK39_1876 ENOG4105DDN Pentapeptide repeat-containing protein AK39_1879 ENOG4105C37 (CBS) domain AK39_1885 ENOG4105EV4 Multidrug resistance protein mdtH AK39_1887 ENOG4105DMQ Methyltransferase AK39_1892 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AK39_1893 ENOG4105C31 Tryptophanyl-tRNA synthetase AK39_1895 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AK39_1898 ENOG4108UW5 maltose o-acetyltransferase AK39_1899 ENOG4106UW1 Major Facilitator superfamily AK39_1900 ENOG4105DKQ ROK family AK39_1901 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AK39_1913 ENOG4105CJ1 ABC, transporter AK39_1915 ENOG4108PSK reductase AK39_1919 ENOG4108RCM Nitroreductase AK39_1920 ENOG4105KVH Transcriptional regulator AK39_1923 ENOG4105CUT histidyl-tRNA synthetase AK39_1924 ENOG4108Z66 YbaK ebsC protein AK39_1926 ENOG41067QW Transcriptional regulator AK39_1929 ENOG4108K8S endonuclease I AK39_193 ENOG4105CEP NADH dehydrogenase AK39_1934 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AK39_1935 ENOG4108JJB ABC transporter AK39_1941 ENOG4105DYS nad(p)h dehydrogenase (quinone) AK39_1943 ENOG4105CRW Short chain fatty acid transporter AK39_1945 ENOG4105KBX Transcriptional regulator, TetR family AK39_1946 ENOG4105KPY Small multidrug resistance protein AK39_1947 ENOG4105RXJ AK39_1949 ENOG41069JR AK39_1950 ENOG4105DA5 (ABC) transporter AK39_1954 ENOG4105CZM Major Facilitator AK39_1955 ENOG4107MII Sugar-specific transcriptional regulator TrmB AK39_1957 ENOG4108ISG Major Facilitator AK39_196 ENOG41069ER domain protein AK39_1965 ENOG4105HIR S-layer domain protein AK39_1968 ENOG410874W AraC family transcriptional regulator AK39_1969 ENOG41082W1 Cupin 2, conserved barrel domain protein AK39_1972 ENOG4108AEY RNA polymerase sigma factor AK39_1976 ENOG4108JQ1 Dehydrogenase AK39_1979 ENOG4105DVH amino acid AK39_1981 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AK39_1984 ENOG4108JPW Aminotransferase AK39_1986 ENOG4105EJQ L-serine dehydratase AK39_1987 ENOG4105C44 Serine transporter AK39_1990 ENOG4108JGH Tetr family transcriptional regulator AK39_1991 ENOG4105EQ0 Major Facilitator superfamily AK39_1992 ENOG4105MZU cell filamentation protein AK39_1995 ENOG4107QJQ Mate efflux family protein AK39_2 ENOG4105CP7 Triose-phosphate isomerase AK39_200 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AK39_2002 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AK39_2010 ENOG4105TRI Hydrolase AK39_2016 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AK39_2018 ENOG4106P55 Transcriptional regulator AK39_2020 ENOG4107QR9 Iron-sulfur cluster binding protein AK39_2021 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AK39_2022 ENOG4105DJB Major Facilitator Superfamily AK39_2023 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AK39_2025 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 AK39_2026 ENOG4108U05 Transcriptional regulator AK39_2029 ENOG4105BZU Histidine kinase AK39_2032 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AK39_2033 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AK39_2036 ENOG4105JQZ Methyltransferase AK39_2037 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AK39_2039 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AK39_204 ENOG4105KA0 thioesterase Superfamily protein AK39_2040 ENOG4108NNI Beta-lactamase domain-containing protein AK39_2043 ENOG4105VZ8 Transcriptional regulator AK39_2049 ENOG4105K6H D-cysteine desulfhydrase AK39_205 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AK39_2054 ENOG41062D9 Histidine kinase AK39_2055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK39_2058 ENOG4105IIP Membrane AK39_2060 ENOG4105C0R drug resistance transporter emrb qaca subfamily AK39_2061 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AK39_2075 ENOG4108YXU transcriptional regulator AsnC family AK39_2076 ENOG4105CHR reductase AK39_2078 ENOG4105F7F Chaperone AK39_208 ENOG4107R3E Citrate transporter AK39_2082 ENOG41085FC arsR family transcriptional regulator AK39_2083 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AK39_2084 ENOG4105D6J arsenicaL-resistance protein AK39_2090 ENOG4105DIK (ABC) transporter AK39_2091 ENOG4105CC5 ABC transporter AK39_2092 ENOG4105DSE periplasmic solute binding protein AK39_2093 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AK39_2094 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AK39_2096 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AK39_2097 ENOG4108TWJ NADH dehydrogenase subunit 5 AK39_210 ENOG4105Y38 Kinase-associated protein B AK39_2100 ENOG4105CVP deoxyribo-dipyrimidine photolyase AK39_2101 ENOG4108606 TspO/MBR family AK39_2109 ENOG41090MY MarR family Transcriptional regulator AK39_2115 ENOG4105CHJ isochorismatase hydrolase AK39_2117 ENOG4105CH6 catalase AK39_2118 ENOG4105CGH 5'-nucleotidase AK39_2126 ENOG4105CSV Glutaminase AK39_213 ENOG4105C87 Aminotransferase class I and II AK39_2131 ENOG4108Q8B Spore germination protein AK39_2132 ENOG4108NHD germination protein AK39_2133 ENOG4108NHD germination protein AK39_2136 ENOG4105C6K Malic enzyme AK39_2138 ENOG4105II7 pyrroline-5-carboxylate reductase AK39_2140 ENOG4105CUB amino acid AK39_2141 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AK39_2143 ENOG4108IMY Transcriptional regulator AK39_2144 ENOG4105HDK L-asparaginase AK39_2145 ENOG4108IJ0 Aspartate ammonia-lyase AK39_2148 ENOG4105E2A Dehydrogenase AK39_215 ENOG4108MUZ hydrolase AK39_216 ENOG4105C5I Dehydrogenase AK39_2164 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AK39_217 ENOG4108ZB6 transcriptional regulator AsnC family AK39_2170 ENOG4105DWD nucleoside recognition domain protein AK39_2174 ENOG4105FDT acyl-CoA dehydrogenase AK39_2176 ENOG4108ZHR arsR family transcriptional regulator AK39_2177 ENOG4108ZRV stage ii sporulation protein p AK39_2178 ENOG4106N3A copper homeostasis protein cutc AK39_218 ENOG4105CHM Aminotransferase AK39_2180 ENOG4107258 Transcriptional regulator AK39_2181 ENOG4105P4J Allophanate hydrolase, subunit 1 AK39_2188 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AK39_2190 ENOG4107RF6 penicillin-binding protein AK39_2198 ENOG4105F1N DNA alkylation repair AK39_220 ENOG4105WG9 Conserved Protein AK39_2200 ENOG4108IQI permease AK39_2201 ENOG4105KNA -acetyltransferase AK39_2202 ENOG410635A Membrane AK39_221 ENOG4107QYV phosphohexose isomerase AK39_2218 ENOG4108XET gCN5-related N-acetyltransferase AK39_222 ENOG4107PBV potassium channel AK39_2224 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AK39_2226 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AK39_2233 ENOG4105FS7 Transcriptional regulator AK39_2234 ENOG4108TVJ Nitroreductase AK39_2236 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AK39_224 ENOG4105KT7 mgtC SapB transporter AK39_2245 ENOG4105C8Y Acetylornithine aminotransferase AK39_2247 ENOG4105CKK Glycosyl transferase, family 2 AK39_2252 ENOG4105CKK Glycosyl transferase, family 2 AK39_2257 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AK39_2262 ENOG41068WN AK39_2264 ENOG4108WCX response regulator AK39_2266 ENOG41090T1 Membrane AK39_2269 ENOG4105VMP Transcriptional regulator AK39_2271 ENOG4105G6Z alkaline phosphatase AK39_2272 ENOG4105ECK Fatty Acid Desaturase AK39_2273 ENOG4105E0Y RtcB Protein AK39_2275 ENOG4107258 Transcriptional regulator AK39_2277 ENOG4105II7 pyrroline-5-carboxylate reductase AK39_2278 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AK39_2284 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AK39_2288 ENOG41061GT Aldolase AK39_2291 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AK39_2292 ENOG4105DKT Transcriptional regulator AK39_2294 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AK39_2296 ENOG4105D4B ABC, transporter AK39_2302 ENOG4105EMN RNA polymerase sigma factor AK39_2304 ENOG41069ER domain protein AK39_2312 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AK39_2313 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AK39_2314 ENOG4105CIH Imidazole acetol-phosphate transaminase AK39_2318 ENOG41082JN Transcriptional regulator AK39_2319 ENOG4105EYF MMPL domain protein AK39_232 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AK39_2320 ENOG4105EYF MMPL domain protein AK39_2322 ENOG4105C5H ABC transporter AK39_2323 ENOG4105E0M Sulfatase AK39_2324 ENOG4108ZCF integral membrane protein AK39_2326 ENOG4107VMI polysaccharide deacetylase AK39_2328 ENOG4107VC0 DNA alkylation repair enzyme AK39_2338 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AK39_2342 ENOG4105E09 nadh pyrophosphatase AK39_2348 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AK39_2349 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AK39_2350 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AK39_2352 ENOG4105C02 permease AK39_2361 ENOG4105DVE abc transporter atp-binding protein AK39_2368 ENOG4105CHM Aminotransferase AK39_2374 ENOG41089UC methyltransferase, type 11 AK39_2377 ENOG4107BMA Transglycosylase associated protein AK39_2381 ENOG4106K7D Major facilitator family transporter AK39_2382 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AK39_2390 ENOG4105EPR degv family AK39_2393 ENOG4105DPN Oligoendopeptidase f AK39_2400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK39_2401 ENOG4105BZU Histidine kinase AK39_2402 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AK39_2410 ENOG4105DTQ mandelate racemase muconate lactonizing AK39_2413 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AK39_2414 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AK39_2417 ENOG4107T5V SNARE associated Golgi AK39_2424 ENOG41080HI glycine oxidase AK39_2425 ENOG4105CTU Proline racemase AK39_2426 ENOG4105CTU Proline racemase AK39_2427 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AK39_2428 ENOG4105C26 Dehydrogenase AK39_2429 ENOG4105BZG amino acid carrier protein AK39_2432 ENOG4108M1A Chitin-binding protein AK39_2440 ENOG4105C9U ATP-dependent DNA helicase RecQ AK39_2444 ENOG4105EEM helicase AK39_2455 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AK39_2464 ENOG4108M1A Chitin-binding protein AK39_2465 ENOG41082BV acetyltransferase AK39_2466 ENOG4105E66 phosphoriboisomerase A AK39_2471 ENOG4108IJ7 Glycine betaine AK39_2472 ENOG4107SQ8 Glycine betaine AK39_2478 ENOG4105RHY Pfam:UPF0157 AK39_2479 ENOG4105E1F short-chain dehydrogenase reductase AK39_2481 ENOG4107RUY (E1 component), alpha subunit AK39_2483 ENOG4107QKR Dehydrogenase AK39_2488 ENOG41062ES Transcriptional regulator AK39_2492 ENOG4105E98 transcriptional regulator DeoR family AK39_2496 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AK39_2503 ENOG4107Z3H Transcriptional regulator, TetR family AK39_2504 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AK39_2505 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AK39_2506 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AK39_251 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AK39_2510 ENOG4105MSI germination protein ypeb AK39_2514 ENOG4108V3A UPF0421 protein AK39_2521 ENOG4105FDR Membrane AK39_2523 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AK39_253 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AK39_2532 ENOG4105DY8 decarboxylase AK39_2537 ENOG4105PAD Hydrolase AK39_2542 ENOG4107VFR oxidoreductase AK39_255 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AK39_2550 ENOG4105PKS Excinuclease abc c subunit domain protein AK39_2557 ENOG4105KWG Pfam:DUF1696 AK39_2558 ENOG4108NRW Phospholipase, patatin family AK39_2564 ENOG4108XI2 Domain of unknown function (DUF1963) AK39_2571 ENOG4108Z4K mutator MutT protein AK39_2572 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AK39_2573 ENOG4105E09 nadh pyrophosphatase AK39_2575 ENOG4105FCD Major Facilitator AK39_2582 ENOG4107Y9U Membrane AK39_2587 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AK39_2591 ENOG4107Y80 Major Facilitator superfamily AK39_2596 ENOG4108V4B ThiJ pfpI AK39_260 ENOG4105VEQ Cold shock protein AK39_2602 ENOG4105FQP Beta-lactamase AK39_2604 ENOG4105CJN penicillin-binding protein AK39_2605 ENOG4105CB2 alcohol dehydrogenase AK39_2608 ENOG4108HGU Histidine kinase AK39_2611 ENOG4108JJB ABC transporter AK39_2615 ENOG4107RF6 penicillin-binding protein AK39_2616 ENOG4105BZU Histidine kinase AK39_2618 ENOG410667J hydrolase AK39_262 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AK39_263 ENOG4105E4F Isochorismate synthase AK39_264 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AK39_2640 ENOG4105ETU transcriptional activator (TenA AK39_265 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AK39_266 ENOG4108IPT Naphthoate synthase AK39_2662 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AK39_2663 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AK39_2666 ENOG4105CPQ Dehydrogenase AK39_2673 ENOG4105CUV Homoserine Kinase AK39_2677 ENOG4107Y80 Major Facilitator superfamily AK39_268 ENOG4105DTQ mandelate racemase muconate lactonizing AK39_2683 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AK39_2683 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AK39_2692 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AK39_2694 ENOG4105T9C HD domain AK39_2697 ENOG4105DZ1 carboxypeptidase AK39_2700 ENOG4105DBI uridine monophosphokinase AK39_2701 ENOG4105WCN acetyltransferase AK39_2703 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AK39_2704 ENOG4107QX3 carboxylase AK39_2705 ENOG4105E39 Enoyl-CoA hydratase AK39_2706 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AK39_2707 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AK39_2708 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AK39_2709 ENOG4105C1G acyl-Coa dehydrogenase AK39_2712 ENOG4107Z3H Transcriptional regulator, TetR family AK39_2714 ENOG4105CJ1 ABC, transporter AK39_2717 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AK39_2718 ENOG4105CEP NADH dehydrogenase AK39_2719 ENOG4106ANW SMI1_KNR4 AK39_2721 ENOG4105BZU Histidine kinase AK39_2723 ENOG4105C5H ABC transporter AK39_2724 ENOG41067SE Tetr family transcriptional regulator AK39_2729 ENOG4108VXD carboxy-peptidase AK39_2732 ENOG4105VZ8 Transcriptional regulator AK39_2737 ENOG4105CGH 5'-nucleotidase AK39_274 ENOG41069H0 dihydroorotase EC 3.5.2.3 AK39_2741 ENOG4105DH8 myo-inositol catabolism AK39_2748 ENOG4105CK5 oxidoreductase AK39_2749 ENOG4105IE8 Alpha-ketoglutarate permease AK39_2750 ENOG4105ETE Transcriptional regulator (LacI family AK39_2751 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AK39_2753 ENOG4107RF6 penicillin-binding protein AK39_2754 ENOG4107RF6 penicillin-binding protein AK39_2755 ENOG4107RF6 penicillin-binding protein AK39_2761 ENOG4105CIN aminoacyl-histidine dipeptidase AK39_2769 ENOG41090HR transcriptional regulator AK39_2770 ENOG4107RA9 decarboxylase AK39_2771 ENOG4108I0C methyltransferase AK39_2773 ENOG41088CC tellurite resistance protein tehB AK39_2778 ENOG4108RZE Tetr family transcriptional regulator AK39_278 ENOG4105FDP GntR family transcriptional regulator AK39_2780 ENOG4105C1J atp-dependent rna helicase AK39_2783 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AK39_2786 ENOG4107STF Involved in phosphonate degradation (By similarity) AK39_2788 ENOG4105RD7 BadF BadG BcrA BcrD AK39_279 ENOG4105C6Z Gluconate AK39_2793 ENOG4105F32 YngK protein AK39_2798 ENOG4108KPJ rna polymerase sigma factor AK39_2804 ENOG4108JCI Transcriptional regulator AK39_2808 ENOG4105BZ1 (ABC) transporter AK39_2809 ENOG4105BZ1 (ABC) transporter AK39_2812 ENOG4108RPX mosc domain containing protein AK39_2813 ENOG4105DND Transcriptional regulator AK39_2816 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AK39_2817 ENOG4107V2S Transcriptional regulator AK39_2825 ENOG410667J hydrolase AK39_2829 ENOG4105VEQ Cold shock protein AK39_2831 ENOG41068WN AK39_2833 ENOG4105C1Q protoporphyrinogen oxidase AK39_2839 ENOG4105WCN acetyltransferase AK39_2844 ENOG4105EYF MMPL domain protein AK39_2846 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AK39_2849 ENOG41081I9 integral membrane protein AK39_2855 ENOG4108D32 Methyltransferase AK39_2861 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AK39_2865 ENOG4105C22 threonyL-tRNA synthetase AK39_2866 ENOG4105FE9 pseudouridine synthase AK39_2870 ENOG4105BZG amino acid carrier protein AK39_2874 ENOG4105K70 DNA-binding protein AK39_2877 ENOG4105C0R drug resistance transporter emrb qaca subfamily AK39_2878 ENOG4105WQT MbtH domain protein AK39_2879 ENOG4105CEY Amp-dependent synthetase and ligase AK39_2880 ENOG4105WQI isochorismatase AK39_2881 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AK39_2882 ENOG4105E4F Isochorismate synthase AK39_2883 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AK39_2884 ENOG4105FCD Major Facilitator AK39_2888 ENOG4105EYH Exonuclease AK39_2889 ENOG4107RFY SbcCD D subunit AK39_2892 ENOG4105E39 Enoyl-CoA hydratase AK39_2893 ENOG4105N14 lysine exporter protein LysE YggA AK39_2895 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AK39_2896 ENOG4105C1G acyl-Coa dehydrogenase AK39_2897 ENOG4105CR4 methylisocitrate lyase AK39_2898 ENOG4105DXD 2-methylcitrate dehydratase AK39_29 ENOG41067MG lrgb family AK39_290 ENOG41086D8 Transcriptional regulator AK39_2900 ENOG4105W8X HesB YadR YfhF-family protein AK39_2901 ENOG4105CZM Major Facilitator AK39_2902 ENOG4105BZ4 penicillin-binding protein AK39_291 ENOG4105C19 ABC transporter AK39_2910 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AK39_2929 ENOG4108IBT Inherit from COG: transposase AK39_2931 ENOG4105SZ6 Thioredoxin AK39_2932 ENOG410841Q phosphoesterase PA-phosphatase related protein AK39_2934 ENOG4108N23 SpoOM-related protein AK39_294 ENOG4107ZTW SNARE associated Golgi AK39_2942 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AK39_2943 ENOG4108JUB Transcriptional regulator AK39_2944 ENOG4108TSC N-acetyltransferase AK39_2945 ENOG4107S4Y M20 DapE family protein YgeY AK39_2948 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AK39_2954 ENOG4105C37 (CBS) domain AK39_2961 ENOG4105E90 ABC transporter AK39_2962 ENOG4108IJ8 ABC transporter AK39_2968 ENOG4105CMG Carbohydrate kinase AK39_2969 ENOG4105CMG Carbohydrate kinase AK39_2977 ENOG4106KNT transcriptional regulator AK39_2979 ENOG4105WH1 Two component transcriptional regulator luxr family AK39_2980 ENOG4105BZU Histidine kinase AK39_2981 ENOG4105D8X mechanosensitive ion channel AK39_2988 ENOG4105F0I Aminotransferase AK39_2989 ENOG4108MES Periplasmic binding protein AK39_2993 ENOG4105CAQ asparagine synthetase AK39_2994 ENOG4107Y70 Heat shock protein AK39_2995 ENOG4108KF3 Electron transport protein SCO1 SenC AK39_2996 ENOG4105E8R UPF0173 metal-dependent hydrolase AK39_2997 ENOG4108RCR degv family AK39_2999 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AK39_3 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AK39_30 ENOG4105XZU Preprotein translocase, subunit SecG AK39_3001 ENOG4108UT2 hemolysin iii AK39_3002 ENOG4105E9Q Acyl-transferase AK39_3003 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AK39_3004 ENOG4107RVG penicillin-binding protein AK39_3007 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AK39_301 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AK39_3011 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AK39_3016 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AK39_3018 ENOG4105KD7 acetyltransferase AK39_302 ENOG4108UGV hypoxanthine phosphoribosyltransferase AK39_3021 ENOG4105C0A alcohol dehydrogenase AK39_3022 ENOG4105CY2 Citrate transporter AK39_3028 ENOG4105C8J )-transporter AK39_3031 ENOG41062D9 Histidine kinase AK39_3032 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK39_3033 ENOG4107QPK )-transporter AK39_3034 ENOG4105BZW Glycerate kinase AK39_3053 ENOG4105EC2 ftsk spoIIIe AK39_3057 ENOG4105C5S asparaginyl-tRNA synthetase AK39_3058 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AK39_3061 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AK39_3067 ENOG4105C75 arginyL-tRNA synthetase AK39_3068 ENOG4107YX5 Pfam:DUF548 AK39_307 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK39_3072 ENOG41061H0 Monooxygenase AK39_3075 ENOG4108UUM single-stranded DNA-binding protein AK39_3078 ENOG4105C5H ABC transporter AK39_308 ENOG4105BZU Histidine kinase AK39_3082 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AK39_3085 ENOG4105MCT stage V sporulation protein S AK39_3092 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AK39_3093 ENOG4108IFG nitrite reductase, (NAD(P)H) AK39_3094 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AK39_3095 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AK39_3096 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AK39_3097 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AK39_3102 ENOG4108ZAF Molybdopterin AK39_3103 ENOG4105CVM Molybdenum cofactor synthesis domain protein AK39_3104 ENOG4105D06 uba thif-type nad fad binding protein AK39_3105 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AK39_3106 ENOG4107V6Q Cyclic nucleotide-binding domain AK39_3111 ENOG4105R3A Nitrate reductase AK39_3112 ENOG4108IUE nitrate reductase beta subunit AK39_3116 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AK39_3119 ENOG4108V06 Glutathione peroxidase AK39_3124 ENOG4105EMN RNA polymerase sigma factor AK39_3125 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AK39_3127 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase AK39_3128 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AK39_3132 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AK39_3137 ENOG4105KBJ sporulation protein ytfj AK39_3146 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AK39_315 ENOG41087YS Phage shock protein A AK39_3152 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AK39_3153 ENOG4108JYZ YitT family AK39_3154 ENOG41087PP glycosyltransferase MGT family AK39_3157 ENOG4107RBS Methyltransferase AK39_3158 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AK39_3160 ENOG4108X4Q Hydrolase AK39_3165 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AK39_3167 ENOG4108VXD carboxy-peptidase AK39_3169 ENOG4108ZRV stage ii sporulation protein p AK39_3172 ENOG4108Z7R Chaperone CsaA AK39_3176 ENOG4105C37 (CBS) domain AK39_3177 ENOG4105SXS Protein of unknown function (DUF456) AK39_3181 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AK39_3182 ENOG4108S4H thioesterase Superfamily protein AK39_3184 ENOG4108PJD permease AK39_3187 ENOG4107T5V SNARE associated Golgi AK39_3191 ENOG4105CVJ phosphoglycerate mutase AK39_3196 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AK39_3198 ENOG4105K4T epimerase AK39_32 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AK39_3200 ENOG4105DSE periplasmic solute binding protein AK39_3212 ENOG4105CKI cobalamin synthesis protein AK39_3213 ENOG4107QM2 Aldo Keto reductase AK39_3217 ENOG4105DEN Luciferase family AK39_3220 ENOG4108WPJ Ferritin-like domain AK39_3221 ENOG4108K88 Membrane AK39_3224 ENOG4105C8Q Methyl-accepting chemotaxis AK39_3229 ENOG4107XZQ multidrug resistance protein AK39_3230 ENOG4107SET aldo keto reductase AK39_3231 ENOG4105YVS arsR family transcriptional regulator AK39_3233 ENOG4105KRN Transcriptional regulator, abrb family AK39_324 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AK39_3244 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AK39_3246 ENOG4107RCC Major Facilitator Superfamily AK39_3247 ENOG4105YWU small acid-soluble spore protein AK39_3248 ENOG4108WBH protein TIM barrel AK39_325 ENOG4105C4M (Ubiquinol oxidase) subunit I AK39_3251 ENOG4105CEY Amp-dependent synthetase and ligase AK39_3252 ENOG4105DUU IucA IucC family protein AK39_3254 ENOG4105VRR gCN5-related N-acetyltransferase AK39_3255 ENOG4105KT7 mgtC SapB transporter AK39_3257 ENOG4107VMI polysaccharide deacetylase AK39_3258 ENOG4105BZU Histidine kinase AK39_3259 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK39_3261 ENOG4108KGH TRANSCRIPTIONal AK39_3266 ENOG4105D6E homoserine dehydrogenase AK39_327 ENOG4108V2W Carbonate dehydratase AK39_3270 ENOG4108ZJ4 polysaccharide deacetylase AK39_3271 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AK39_3274 ENOG4105BZU Histidine kinase AK39_3275 ENOG4105EFI regulatoR AK39_3276 ENOG4105BZ1 (ABC) transporter AK39_3277 ENOG4105BZ1 (ABC) transporter AK39_3285 ENOG4108JJ8 (ABC) transporter AK39_3286 ENOG4108JJ9 ABC, transporter AK39_3287 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AK39_3288 ENOG4105C4M (Ubiquinol oxidase) subunit I AK39_3294 ENOG4105SKE transcriptional Regulator LysR family AK39_3296 ENOG4105C32 Amino acid ABC transporter (Permease) AK39_3297 ENOG4108IV0 ABC, transporter AK39_3298 ENOG4105C0Z ABC transporter AK39_3300 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AK39_3301 ENOG4108Z7G MaoC domain protein dehydratase AK39_3305 ENOG4105CKI cobalamin synthesis protein AK39_3307 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AK39_3308 ENOG4106F5Q Membrane AK39_3309 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AK39_3311 ENOG4108TVJ Nitroreductase AK39_3312 ENOG4107ZXU DSBA oxidoreductase AK39_3313 ENOG4108Z40 Transcriptional regulator AK39_3314 ENOG4105GZI Transcriptional regulator AK39_3315 ENOG4107RT3 EamA-like transporter family AK39_3317 ENOG4105KTB nuclear export factor GLE1 AK39_3318 ENOG4108T5E Copper resistance protein AK39_3328 ENOG4107STQ Multicopper oxidase AK39_3329 ENOG4107RAQ aminopeptidase AK39_3335 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AK39_3336 ENOG4105D9N nucleoside AK39_3338 ENOG4107RHR regulatoR AK39_334 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AK39_3343 ENOG4105C0X amino acid AK39_3344 ENOG4105C0X amino acid AK39_3346 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AK39_3348 ENOG4105C72 UPF0176 protein AK39_3349 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AK39_3353 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK39_3354 ENOG41068WN AK39_3360 ENOG4108J59 Extracellular solute-binding protein, family 5 AK39_3361 ENOG4105F6J Alpha beta hydrolase fold AK39_3365 ENOG4105CYC Transferase AK39_3366 ENOG4105DY9 regulatoR AK39_3368 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AK39_3369 ENOG4105C6X Major Facilitator AK39_3374 ENOG4105C7B Threonine dehydratase AK39_3376 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AK39_3377 ENOG4108ZP8 Acetolactate synthase small subunit AK39_3378 ENOG4105C7K acetolactate synthase AK39_3379 ENOG4105CM2 brancheD-chain amino acid aminotransferase AK39_338 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AK39_3380 ENOG4105CHR reductase AK39_3381 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AK39_3385 ENOG4106KE4 Dehydrogenase AK39_3388 ENOG4105H67 Protein of unknown function (DUF421) AK39_3389 ENOG4105X5K response regulator receiver protein AK39_3391 ENOG4105C8J )-transporter AK39_3395 ENOG4105C6T cysteine synthase AK39_3396 ENOG4105EU0 Major facilitator Superfamily AK39_3399 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AK39_340 ENOG4105D2X ABC transporter substrate-binding protein AK39_3402 ENOG4105DXI Major Facilitator superfamily AK39_3403 ENOG4105DXI Major Facilitator superfamily AK39_3404 ENOG4105CSR polyphosphate kinase 2 AK39_3412 ENOG4105FVX AK39_3425 ENOG4105C6K Malic enzyme AK39_3426 ENOG4108IJ0 Aspartate ammonia-lyase AK39_3428 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AK39_3432 ENOG4105CJ1 ABC, transporter AK39_3439 ENOG4106BRA Membrane AK39_344 ENOG4107T7U Sulfatase AK39_3446 ENOG4107QIV Cytochrome c biogenesis protein AK39_345 ENOG4107S9D Alpha beta hydrolase AK39_3450 ENOG4105EC3 peptidase S51, dipeptidase E AK39_3451 ENOG4107QJQ Mate efflux family protein AK39_3452 ENOG4107QJQ Mate efflux family protein AK39_3456 ENOG4105C9Q fumarate hydratase class II AK39_3457 ENOG4105DFD Na H antiporter AK39_346 ENOG4105BZU Histidine kinase AK39_3460 ENOG4108PJD permease AK39_3461 ENOG4105CKI cobalamin synthesis protein AK39_3462 ENOG4108UZ3 Transporter AK39_3463 ENOG4105DRR Transcriptional regulator, GntR family AK39_3465 ENOG4105PGM cation diffusion facilitator family transporter AK39_3469 ENOG4105CAQ asparagine synthetase AK39_347 ENOG4105BZU Histidine kinase AK39_3476 ENOG4105CVJ phosphoglycerate mutase AK39_348 ENOG4105EGD dinuclear metal center protein, YbgI family AK39_3483 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AK39_3484 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AK39_3485 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AK39_3486 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AK39_3487 ENOG4105DUM transcriptional regulator, lysR family AK39_3492 ENOG4105KAC Antibiotic biosynthesis monooxygenase AK39_3496 ENOG4108RZE Tetr family transcriptional regulator AK39_3501 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AK39_3502 ENOG4105KTQ flagellar basal-body rod protein AK39_3505 ENOG4105D7B Flagellar biosynthesis protein flha AK39_3506 ENOG4105D00 flagellar biosynthetic protein flhB AK39_3508 ENOG4105VS8 Flagellar biosynthetic protein fliq AK39_3509 ENOG4105CN7 Flagellar biosynthetic protein FliP AK39_3511 ENOG4105DD5 Flagellar motor switch protein AK39_3513 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AK39_3514 ENOG4105E4C Lytic transglycosylase catalytic AK39_3515 ENOG4105I03 Flagellin AK39_3520 ENOG4107TVC Glycosyl transferase, family 2 AK39_3526 ENOG4105K64 Glycosyl transferase, family 2 AK39_3528 ENOG4107R88 Chemotaxis protein (CheV) AK39_3532 ENOG4105BZE flagellar hook protein, FlgE AK39_3539 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AK39_3541 ENOG4107U2N Flagellar M-ring protein AK39_3542 ENOG41075Z6 flagellar hook-basal body complex protein fliE AK39_3543 ENOG4108ZC9 flagellar basal-body rod protein flgc AK39_3544 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AK39_3549 ENOG4105DTJ flagellar hook-associated protein AK39_3550 ENOG4105E1Q flagellar hook-associated protein AK39_3554 ENOG4105BZU Histidine kinase AK39_3557 ENOG4105DD5 Flagellar motor switch protein AK39_3558 ENOG4105CBS Chea signal transduction histidine kinase AK39_3559 ENOG4105CBS Chea signal transduction histidine kinase AK39_3560 ENOG4107YTP response regulator receiver protein AK39_3561 ENOG4105ER2 Ompa motb domain protein AK39_3562 ENOG4107R0U MotA TolQ exbB proton channel AK39_3564 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AK39_3575 ENOG41080C8 DUF218 domain AK39_3576 ENOG4105H67 Protein of unknown function (DUF421) AK39_358 ENOG4108RIR Molybdenum cofactor biosynthesis protein AK39_3580 ENOG4105CN5 Metallo-Beta-Lactamase AK39_3581 ENOG4107RWR Sodium hydrogen exchanger AK39_3583 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AK39_3596 ENOG41081VK Ribonuclease AK39_360 ENOG4105BZF Glycosyl transferase (Group 1 AK39_3600 ENOG4108SZE gCN5-related N-acetyltransferase AK39_361 ENOG4105YVM Phosphoesterase, PA-phosphatase related AK39_3618 ENOG4106032 Glutathionylspermidine synthase AK39_362 ENOG4108Z0R Transferase AK39_3621 ENOG4105KHC sulfurtransferase AK39_3623 ENOG4108W0I acetyltransferase AK39_3625 ENOG410890F Dynamin family AK39_3627 ENOG4105DHF Membrane AK39_3628 ENOG4105C2W permease AK39_363 ENOG4105E8V Alpha Beta Hydrolase Fold protein AK39_3630 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AK39_3633 ENOG4105CTD carboxy-peptidase AK39_3634 ENOG4105DVT helicase AK39_3636 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AK39_3647 ENOG4105BZ4 penicillin-binding protein AK39_3649 ENOG4105CSM endonuclease III AK39_3653 ENOG4105YAC AK39_3654 ENOG4105DVT helicase AK39_3661 ENOG4105CPK Glycosyl transferase (Group 1 AK39_3662 ENOG4105FJR Lmbe family AK39_3665 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AK39_3666 ENOG4108JYZ YitT family AK39_3672 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AK39_3673 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AK39_3674 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AK39_3677 ENOG41068YB TPR repeat-containing protein AK39_3678 ENOG4105CIH Imidazole acetol-phosphate transaminase AK39_3682 ENOG4105EAH synthase AK39_3684 ENOG4105XXQ heptaprenyl diphosphate synthase component I AK39_3687 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AK39_369 ENOG4105DA5 (ABC) transporter AK39_3693 ENOG41065D1 AK39_3694 ENOG4105S2F AK39_37 ENOG4105CM4 permease protein AK39_3701 ENOG4107RB3 L-asparaginase AK39_3702 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AK39_3707 ENOG4108S6Z Negative regulator of genetic competence AK39_3708 ENOG4107X2D transcriptional regulator, merr family AK39_3709 ENOG4107RGJ metallophosphoesterase AK39_371 ENOG4105N5T Radical SAM Protein AK39_3711 ENOG4105I7S Abortive infection protein AK39_3712 ENOG4105C9U ATP-dependent DNA helicase RecQ AK39_3713 ENOG4105T7X AK39_3715 ENOG4108SAX Membrane AK39_3718 ENOG4108WBT adenosyltransferase AK39_3719 ENOG4105BZU Histidine kinase AK39_3720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK39_3721 ENOG4105CRE cytochrome C AK39_3722 ENOG4107TWT Cytochrome c biogenesis protein AK39_3724 ENOG4105FE9 pseudouridine synthase AK39_3726 ENOG4108JIC nucleoside recognition domain protein AK39_3727 ENOG4105DZ1 carboxypeptidase AK39_3728 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AK39_3735 ENOG4105BZU Histidine kinase AK39_3738 ENOG4105I3N Conserved Protein AK39_3739 ENOG4105BZU Histidine kinase AK39_3742 ENOG4105BZ4 penicillin-binding protein AK39_3743 ENOG4107GRR phosphate transport regulator AK39_3744 ENOG4105CJ3 phosphate transporter AK39_3748 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AK39_375 ENOG4105C19 ABC transporter AK39_3753 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AK39_3757 ENOG4105WH1 Two component transcriptional regulator luxr family AK39_3758 ENOG4105ENE Histidine kinase AK39_3762 ENOG4105DFD Na H antiporter AK39_3766 ENOG4105C8J )-transporter AK39_3767 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AK39_3768 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AK39_3769 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AK39_3771 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AK39_3772 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AK39_3776 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AK39_3778 ENOG4105E0M Sulfatase AK39_3779 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AK39_378 ENOG4105NCW Trka-c domain protein AK39_3782 ENOG4107RVV histidinol phosphate phosphatase, hisj family AK39_3789 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AK39_379 ENOG4107S91 Sodium hydrogen exchanger AK39_3794 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AK39_3796 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AK39_3797 ENOG4108ZP8 Acetolactate synthase small subunit AK39_3798 ENOG4105C7K acetolactate synthase AK39_3799 ENOG4105CM2 brancheD-chain amino acid aminotransferase AK39_38 ENOG4108IPW abc transporter atp-binding protein AK39_380 ENOG410605W Major Facilitator AK39_3804 ENOG4105KBJ sporulation protein ytfj AK39_3805 ENOG41063Y9 AK39_3806 ENOG4105CZN Potassium uptake protein AK39_3812 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AK39_3813 ENOG4107QMU Mate efflux family protein AK39_3820 ENOG4105NQC Flavodoxin AK39_3825 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AK39_3827 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AK39_3828 ENOG4105EA8 2-Nitropropane dioxygenase AK39_3829 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AK39_3837 ENOG4105CJ1 ABC, transporter AK39_3839 ENOG4105CZV ABC transporter AK39_3840 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AK39_3841 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AK39_3842 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AK39_3844 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AK39_3845 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AK39_3854 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AK39_3855 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AK39_3857 ENOG4105BZU Histidine kinase AK39_3859 ENOG4106DF1 AK39_386 ENOG4108B31 Spore germination protein AK39_3861 ENOG41090MY MarR family Transcriptional regulator AK39_3862 ENOG4105BZU Histidine kinase AK39_3864 ENOG4105PXI polysaccharide deacetylase AK39_3866 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AK39_3867 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AK39_3872 ENOG4105E98 transcriptional regulator DeoR family AK39_3875 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AK39_3876 ENOG4107RCV ABC transporter, permease AK39_3879 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AK39_388 ENOG4105DWV Homoserine O-trans-acetylase AK39_3881 ENOG4105C4Y ABC transporter AK39_3885 ENOG4105MWK D-amino acid dehydrogenase, small subunit AK39_3887 ENOG4105CHR reductase AK39_3891 ENOG4108Z7G MaoC domain protein dehydratase AK39_3892 ENOG410681C small acid-soluble spore protein AK39_3893 ENOG4105CZN Potassium uptake protein AK39_3894 ENOG4107TS3 membrane protein, TerC AK39_3895 ENOG4108QTI )-transporter AK39_3897 ENOG4106A3R peptidase AK39_390 ENOG41085GJ domain protein AK39_3901 ENOG4105JXH GntR family transcriptional regulator AK39_3902 ENOG4105BZU Histidine kinase AK39_3903 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK39_3906 ENOG4105CQB FAD linked oxidase domain protein AK39_3907 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AK39_3908 ENOG4105K4I Scp-like extracellular AK39_3910 ENOG4108YBP pseudouridine synthase AK39_3912 ENOG4105EYF MMPL domain protein AK39_3914 ENOG4107RUE extracellular solute-binding protein family 1 AK39_3915 ENOG4105D38 putrescine abc transporter AK39_3916 ENOG4105F38 ABC transporter, permease AK39_3917 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AK39_3918 ENOG4105C26 Dehydrogenase AK39_3924 ENOG4105VFR signal peptidase AK39_3925 ENOG4105DZ1 carboxypeptidase AK39_3927 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AK39_3938 ENOG4105VZ8 Transcriptional regulator AK39_394 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AK39_3940 ENOG4105C7S Dehydrogenase AK39_395 ENOG4105D06 uba thif-type nad fad binding protein AK39_3958 ENOG4105DDQ anthranilate synthase AK39_3959 ENOG4105CRQ synthase (Component I) AK39_3960 ENOG4105CK7 Sodium proline symporter AK39_3965 ENOG4108WVJ 2'-5' rna ligase AK39_397 ENOG4105CVM Molybdenum cofactor synthesis domain protein AK39_3974 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AK39_3976 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AK39_3977 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AK39_398 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AK39_3981 ENOG4107TVC Glycosyl transferase, family 2 AK39_3985 ENOG4105K64 Glycosyl transferase, family 2 AK39_3987 ENOG4105CNI cell division protein FtsW AK39_399 ENOG4108ZAF Molybdopterin AK39_3991 ENOG4105EMS pseudouridine synthase AK39_3992 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AK39_3995 ENOG4105MIX Adenylate cyclase AK39_3996 ENOG4108Z18 K06886 hemoglobin AK39_3999 ENOG4105DPN Oligoendopeptidase f AK39_4001 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AK39_4003 ENOG4108ZCF integral membrane protein AK39_4007 ENOG4105UQX Mate efflux family protein AK39_4008 ENOG4108JQ7 (ABC) transporter AK39_4010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AK39_4011 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AK39_4014 ENOG4105C31 Tryptophanyl-tRNA synthetase AK39_4017 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AK39_4018 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AK39_402 ENOG4105CSC Glucose uptake protein AK39_4023 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AK39_4025 ENOG4108KP7 hydrolase AK39_4027 ENOG41073B9 AK39_4028 ENOG4107AYK membrAne AK39_403 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AK39_4030 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AK39_4032 ENOG4105QNR S1 RNA binding domain protein AK39_4036 ENOG4105BZU Histidine kinase AK39_4037 ENOG4105CH6 catalase AK39_4038 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AK39_4039 ENOG4105CAQ asparagine synthetase AK39_404 ENOG4108VJ1 Transcriptional regulator (CarD family AK39_4044 ENOG4105ERH Fumarylacetoacetate hydrolase AK39_4052 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AK39_4053 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AK39_4056 ENOG4105XVF Competence transcription factor AK39_4059 ENOG4105VEQ Cold shock protein AK39_4062 ENOG4107QP3 malate synthase g AK39_4063 ENOG4105ZU5 s-layer protein AK39_4067 ENOG4105C8Q Methyl-accepting chemotaxis AK39_4068 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AK39_4073 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK39_4077 ENOG41086D8 Transcriptional regulator AK39_4078 ENOG4108AEY RNA polymerase sigma factor AK39_4080 ENOG4107TVP HD domain protein AK39_4081 ENOG4107RN3 metallophosphoesterase AK39_4083 ENOG4105ENX hydrolase AK39_4088 ENOG4105CNA YD repeat protein AK39_4094 ENOG4105CEY Amp-dependent synthetase and ligase AK39_4096 ENOG4105DF9 Lipoate-protein, ligase AK39_4097 ENOG4108RQ5 Beta-lactamase domain-containing protein AK39_4098 ENOG4106AXD AK39_41 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AK39_4104 ENOG4105ECB domain protein AK39_4107 ENOG4105NA0 Transcriptional regulator AK39_411 ENOG4105CBX hi0933 family AK39_4112 ENOG4105C1Q protoporphyrinogen oxidase AK39_4114 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AK39_4115 ENOG4105BZ4 penicillin-binding protein AK39_4116 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AK39_4117 ENOG4105CKV Membrane AK39_4118 ENOG410905X membrane-flanked domain protein AK39_4127 ENOG4105CKV Membrane AK39_4129 ENOG410905X membrane-flanked domain protein AK39_4136 ENOG4105K59 histidine triad (HIT) protein AK39_414 ENOG4105YW5 deoR family transcriptional regulator AK39_4141 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AK39_4142 ENOG4105EEM helicase AK39_4144 ENOG4105C0R drug resistance transporter emrb qaca subfamily AK39_4145 ENOG4105C57 major facilitator superfamily AK39_415 ENOG4107QSE Dipeptidase AK39_4150 ENOG4105EMN RNA polymerase sigma factor AK39_4153 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AK39_4156 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AK39_416 ENOG4107QSE Dipeptidase AK39_4160 ENOG4108MUZ hydrolase AK39_4165 ENOG4105EQ0 Major Facilitator superfamily AK39_4166 ENOG4108IND Tetr family transcriptional regulator AK39_4169 ENOG4105D7V transposase AK39_4170 ENOG4106D4I domain protein AK39_4171 ENOG4107VRP DNA repair exonuclease AK39_4177 ENOG4105K8R UPF0145 protein AK39_418 ENOG4108IUM Glycogen debranching enzyme AK39_4182 ENOG4105BZU Histidine kinase AK39_4183 ENOG4105BZU Histidine kinase AK39_4184 ENOG4108MJI response regulator AK39_4186 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK39_4188 ENOG4105WN5 stage II sporulation protein AK39_419 ENOG4108V15 phosphotransferase enzyme family AK39_42 ENOG4108MK9 spermidine N(1)-acetyltransferase AK39_4201 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AK39_4206 ENOG410847I Transcriptional regulator, BadM Rrf2 family AK39_4207 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AK39_4208 ENOG4105CMT Dihydroxyacetone kinase AK39_4210 ENOG4105CMT Dihydroxyacetone kinase AK39_4214 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AK39_4218 ENOG4108IG5 Transcriptional regulator AK39_4219 ENOG4107P5I polyketide synthase AK39_422 ENOG4105C8F Beta-lactamase domain protein AK39_4229 ENOG4105C0R drug resistance transporter emrb qaca subfamily AK39_4237 ENOG4105CDU Replicative dna helicase AK39_4246 ENOG4108MRH transcriptional regulatory protein AK39_4248 ENOG4105CSH Transporter AK39_4254 ENOG4108JQ7 (ABC) transporter AK39_4257 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AK39_4265 ENOG4105CTU Proline racemase AK39_4270 ENOG4105DER m42 family AK39_4273 ENOG4105CGU Enoyl-CoA hydratase AK39_4276 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AK39_4277 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AK39_4279 ENOG4106AKK s-layer domain-containing protein AK39_428 ENOG4108VDD TRNA binding domain protein AK39_4287 ENOG4105CHH sulfate transporter AK39_4290 ENOG4105D4P Coproporphyrinogen iii oxidase AK39_4292 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AK39_4297 ENOG4107FQX Alpha-acetolactate decarboxylase AK39_4304 ENOG410839P AK39_4307 ENOG4105CDA abc transporter atp-binding protein AK39_4308 ENOG4105DRP amino acid AbC transporter AK39_4310 ENOG4105BZ1 (ABC) transporter AK39_4311 ENOG4105BZ1 (ABC) transporter AK39_4312 ENOG4105BZ1 (ABC) transporter AK39_4313 ENOG4105C26 Dehydrogenase AK39_4315 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AK39_4316 ENOG4105D5Q Arginine ornithine antiporter AK39_4318 ENOG4105CH6 catalase AK39_4319 ENOG4107RKG DJ-1/PfpI family AK39_4321 ENOG4105E5W Transporter AK39_4322 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AK39_4323 ENOG4105NF4 modulator of drug activity AK39_4328 ENOG4105KPY Small multidrug resistance protein AK39_4329 ENOG4105KPY Small multidrug resistance protein AK39_4331 ENOG4108YXU transcriptional regulator AsnC family AK39_4332 ENOG4108PCN EamA-like transporter family AK39_4339 ENOG4106KNT transcriptional regulator AK39_4341 ENOG4107RWR Sodium hydrogen exchanger AK39_4342 ENOG4105CUB amino acid AK39_4348 ENOG4107T5V SNARE associated Golgi AK39_4355 ENOG4105WEF catalase AK39_4361 ENOG4105C19 ABC transporter AK39_4362 ENOG4107RBB ABC transporter, permease AK39_4363 ENOG41069ER domain protein AK39_4367 ENOG4105VZJ PTS System AK39_4368 ENOG4105VCP PTS System AK39_4369 ENOG4105EMD TRANSCRIPTIONal AK39_437 ENOG4105C88 aminopeptidase AK39_4374 ENOG4108KGH TRANSCRIPTIONal AK39_4376 ENOG41087NI Sulfite exporter TauE/SafE AK39_4377 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AK39_4379 ENOG41085GJ domain protein AK39_4381 ENOG4105VFE sira family AK39_4382 ENOG4107TPS domain protein AK39_4383 ENOG4105VFE sira family AK39_4384 ENOG4105XTG Pfam:DUF156 AK39_4385 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AK39_4390 ENOG4105ED1 spovr family AK39_4391 ENOG4107Y03 Nitroreductase AK39_4396 ENOG4108B31 Spore germination protein AK39_4403 ENOG4105C5Y PTS System AK39_441 ENOG4105ETE Transcriptional regulator (LacI family AK39_4410 ENOG4105C7N Xanthine uracil vitamin C permease AK39_4413 ENOG4108INS Transcriptional regulator AK39_4422 ENOG4105DWF phosphomethylpyrimidine kinase AK39_4423 ENOG4105D06 uba thif-type nad fad binding protein AK39_4426 ENOG41080HI glycine oxidase AK39_4427 ENOG4108VEU Thiamine monophosphate synthase AK39_4429 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AK39_4431 ENOG4105ETU transcriptional activator (TenA AK39_4435 ENOG41080XQ Signal transduction protein with cbs domains AK39_4462 ENOG4105E2Z phosphate ABC transporter (Permease AK39_4463 ENOG4105C8U phosphate abc transporter AK39_4464 ENOG4105CVA phosphate AK39_4465 ENOG4105CE1 Ferrous iron transport protein b AK39_4466 ENOG4105CE1 Ferrous iron transport protein b AK39_4467 ENOG4105CE1 Ferrous iron transport protein b AK39_4468 ENOG4108NHD germination protein AK39_447 ENOG4105EP9 oxidoreductase AK39_4471 ENOG4105E1V na solute symporter AK39_4472 ENOG4106CAD Protein of unknown function (DUF3311) AK39_4475 ENOG4105E2S oxidase) subunit II AK39_4476 ENOG4105BZ9 Cytochrome C oxidase, subunit I AK39_448 ENOG4107SNB ankyrin repeat protein YahD AK39_4484 ENOG4105C7N Xanthine uracil vitamin C permease AK39_4485 ENOG4105C85 amino acid AK39_4489 ENOG4105DUX Transporter AK39_4491 ENOG4107D63 AK39_4492 ENOG4105VZ8 Transcriptional regulator AK39_4493 ENOG41069ER domain protein AK39_4494 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AK39_4495 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AK39_45 ENOG4105WMR Protein CrcB homolog AK39_450 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK39_4507 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AK39_4508 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AK39_4509 ENOG4105CNN ABC, transporter AK39_4510 ENOG4105C2J ABC transporter AK39_4512 ENOG4108RVA ribokinase AK39_4513 ENOG4105ETE Transcriptional regulator (LacI family AK39_4514 ENOG4105C0R drug resistance transporter emrb qaca subfamily AK39_4515 ENOG4105C0R drug resistance transporter emrb qaca subfamily AK39_4516 ENOG41067TZ transcriptional regulator, MarR family AK39_4517 ENOG4105CXY transporter AK39_4519 ENOG4108JQ7 (ABC) transporter AK39_452 ENOG4105DGU Histone deacetylase AK39_4520 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AK39_4522 ENOG4105DEF Extracellular solute-binding protein, family 5 AK39_4524 ENOG41068KF Universal stress protein AK39_4525 ENOG4105CHH sulfate transporter AK39_4528 ENOG4105BZU Histidine kinase AK39_4529 ENOG4105NAE bifunctional deaminase-reductase domain protein AK39_453 ENOG4105W87 Cbs domain AK39_4530 ENOG4105D29 Helix-turn-helix type 11 domain protein AK39_4535 ENOG4108IQI permease AK39_4536 ENOG4105DRP amino acid AbC transporter AK39_4537 ENOG4105EAD ABC transporter AK39_4538 ENOG4105CT1 (ABC) transporter AK39_4539 ENOG4105CDA abc transporter atp-binding protein AK39_454 ENOG4105F1V Acetoin utilization protein AK39_4540 ENOG4105BZG amino acid carrier protein AK39_4541 ENOG4105CRN Aminoglycoside phosphotransferase AK39_4543 ENOG4105E1K spore germination protein AK39_4546 ENOG4105CG3 alpha amylase, catalytic region AK39_4547 ENOG4105C5Y PTS System AK39_4548 ENOG4107414 GntR family transcriptional regulator AK39_4549 ENOG4105D5Q Arginine ornithine antiporter AK39_4550 ENOG4105BZU Histidine kinase AK39_4553 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AK39_4554 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AK39_4555 ENOG4107T89 von Willebrand factor, type A AK39_4557 ENOG4105EXW epimerase dehydratase AK39_4559 ENOG4105DMQ Methyltransferase AK39_4560 ENOG4105E0A ABC, transporter AK39_4561 ENOG4108IHU transport system permease protein AK39_4562 ENOG4105DQ5 transport system permease protein AK39_4563 ENOG4108MES Periplasmic binding protein AK39_4564 ENOG4105DUX Transporter AK39_4567 ENOG4105DAA L-lactate AK39_4568 ENOG4108IJ0 Aspartate ammonia-lyase AK39_4569 ENOG4105C37 (CBS) domain AK39_457 ENOG4105EMN RNA polymerase sigma factor AK39_4570 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AK39_4571 ENOG4105D9N nucleoside AK39_4572 ENOG4108KGH TRANSCRIPTIONal AK39_4573 ENOG41073R8 VanW family AK39_4581 ENOG4105DAP Nicotinate phosphoribosyltransferase AK39_4582 ENOG4105C59 p-type ATPase AK39_4584 ENOG4105CUB amino acid AK39_4589 ENOG4108JB9 formate dehydrogenase AK39_459 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AK39_4590 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AK39_4591 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AK39_4593 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK39_4594 ENOG4105BZU Histidine kinase AK39_4596 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AK39_4597 ENOG4108UZ3 Transporter AK39_4599 ENOG4105C6K Malic enzyme AK39_46 ENOG4105WMR Protein CrcB homolog AK39_4601 ENOG4108MRH transcriptional regulatory protein AK39_4606 ENOG4105US7 Histidine kinase AK39_4607 ENOG4108STX response regulator AK39_4608 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AK39_4609 ENOG4105BZ7 extracellular solute-binding protein family 1 AK39_4610 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AK39_4611 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AK39_4612 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AK39_4613 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AK39_4617 ENOG4105D4T Citrate transporter AK39_4620 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AK39_4622 ENOG4105DZ6 Band 7 protein AK39_4625 ENOG4105C94 Transporter AK39_4629 ENOG4105CYN Serine protein kinase AK39_463 ENOG4105C28 cystathionine AK39_4631 ENOG4105BZU Histidine kinase AK39_4632 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AK39_4634 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AK39_4636 ENOG4107ZQN disulfide bond AK39_4637 ENOG4108JQC penicillin-binding protein 1A AK39_465 ENOG4105U5Y Transcriptional regulator AK39_466 ENOG4105U5Y Transcriptional regulator AK39_4662 ENOG4105G5W regulator Fur family AK39_4663 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AK39_4667 ENOG4108IUW ABC transporter AK39_4669 ENOG4105CBC glutamate synthase AK39_4670 ENOG4107NBY Membrane AK39_4671 ENOG4105BZ1 (ABC) transporter AK39_4675 ENOG4106BXE AK39_4676 ENOG4105CEN a g-specific adenine glycosylase AK39_4677 ENOG41067AE Membrane-bound metal-dependent hydrolase AK39_468 ENOG4106KR7 LysR family Transcriptional regulator AK39_4683 ENOG4105ECP epimerase AK39_4684 ENOG4105CI2 imidazolone-5-propionate hydrolase AK39_4688 ENOG4105F1A Pyruvate formate-lyase AK39_4691 ENOG4105C3I Nad-dependent epimerase dehydratase AK39_4692 ENOG4107QQG Dehydrogenase AK39_4694 ENOG4105CKK Glycosyl transferase, family 2 AK39_4697 ENOG4108A04 Beta-lactamase AK39_4699 ENOG4105CSV Glutaminase AK39_4705 ENOG4108IQI permease AK39_4707 ENOG4108JUB Transcriptional regulator AK39_4709 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AK39_476 ENOG4105EFZ amidohydrolase AK39_4767 ENOG4105VTR Integrase AK39_4768 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AK39_4776 ENOG4105UPD Calcium Proton AK39_4777 ENOG410606W general stress protein AK39_4780 ENOG4107ZTW SNARE associated Golgi AK39_4783 ENOG4105C3F Signal peptidase i AK39_4785 ENOG4108IPJ Membrane AK39_4786 ENOG4105C59 p-type ATPase AK39_4787 ENOG4107U9T Pfam:Ribonuclease_BN AK39_4789 ENOG4105KJF protein tyrosine phosphatase AK39_479 ENOG4105KBJ sporulation protein ytfj AK39_4793 ENOG4108TTB tellurium resistance protein AK39_4794 ENOG4107TS3 membrane protein, TerC AK39_4795 ENOG4106FN3 tellurium resistance protein AK39_4796 ENOG4106FN3 tellurium resistance protein AK39_4797 ENOG4108N0M stress protein AK39_48 ENOG4105C8Q Methyl-accepting chemotaxis AK39_480 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AK39_4800 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) AK39_4803 ENOG4105DEU major facilitator superfamily AK39_4807 ENOG41062JF Transcriptional regulator AK39_4812 ENOG4105C5H ABC transporter AK39_4815 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AK39_4818 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AK39_482 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AK39_4824 ENOG4105CI1 PTS System AK39_4826 ENOG4105C8Q Methyl-accepting chemotaxis AK39_4827 ENOG4105C8Q Methyl-accepting chemotaxis AK39_4829 ENOG4105EAB amino acid AbC transporter AK39_4830 ENOG4105E5Q amino acid AbC transporter AK39_4833 ENOG4105D2S major facilitator superfamily AK39_4834 ENOG410756H nucleotidyltransferase AK39_4838 ENOG4105BZU Histidine kinase AK39_4842 ENOG4106UIA AK39_4843 ENOG4106UIA AK39_4847 ENOG4108V5C ABC transporter AK39_4848 ENOG4105DQ5 transport system permease protein AK39_4849 ENOG4105EHG Permease protein AK39_4850 ENOG4107W7X Aldolase AK39_4852 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AK39_4853 ENOG4105D3R alkyl hydroperoxide reductase AK39_4858 ENOG4105DFD Na H antiporter AK39_4859 ENOG4105DTQ mandelate racemase muconate lactonizing AK39_486 ENOG4108JYZ YitT family AK39_4862 ENOG4108W15 Protein of unknown function (DUF1456) AK39_4865 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AK39_4866 ENOG4105D9N nucleoside AK39_4870 ENOG4105KPY Small multidrug resistance protein AK39_4871 ENOG4105C26 Dehydrogenase AK39_4873 ENOG4108JPW Aminotransferase AK39_4874 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AK39_4875 ENOG4105CBD Diacylglycerol kinase AK39_4880 ENOG410834F Transcriptional regulator AK39_4881 ENOG4105D0U Arsenite-activated ATPase (ArsA) AK39_4885 ENOG4105D01 (LipO)protein AK39_4886 ENOG4108UMI ABC transporter, permease AK39_4887 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AK39_4888 ENOG4108W2Y isochorismatase AK39_4894 ENOG4105C4R Atp-dependent dna helicase AK39_4899 ENOG4105C12 Phosphoribosylglycinamide synthetase AK39_4901 ENOG4108V3E phosphoribosylglycinamide formyltransferase AK39_4906 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AK39_4908 ENOG4105C83 adenylosuccinate lyase AK39_4909 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AK39_4910 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AK39_4915 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK39_4919 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AK39_4923 ENOG4108SHN Glycosyl transferase, family 2 AK39_4929 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AK39_4936 ENOG4105BZU Histidine kinase AK39_4938 ENOG4105C7N Xanthine uracil vitamin C permease AK39_4942 ENOG4108TYN CAAX amino terminal protease family protein AK39_4945 ENOG4105C5H ABC transporter AK39_4946 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AK39_4947 ENOG410801F ribosomal-protein-alanine acetyltransferase AK39_4948 ENOG41072GX Peptidase M22 Glycoprotease AK39_4949 ENOG4105K8N protein family UPF0079, ATPase AK39_495 ENOG4107YZX Universal stress protein AK39_4969 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AK39_4971 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AK39_4972 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AK39_4975 ENOG4107ZXI Rhomboid family AK39_4977 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AK39_4978 ENOG4105CPF Cell wall formation (By similarity) AK39_4979 ENOG4105CPF Cell wall formation (By similarity) AK39_4980 ENOG4108SC4 )-transporter AK39_4982 ENOG4105ERH Fumarylacetoacetate hydrolase AK39_4983 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AK39_4987 ENOG4108JQ7 (ABC) transporter AK39_4988 ENOG410667J hydrolase AK39_4989 ENOG4105C3U ABC transporter AK39_499 ENOG4105VZ8 Transcriptional regulator AK39_4990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AK39_4992 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AK39_4995 ENOG4105C5H ABC transporter AK39_4999 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AK39_5 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AK39_50 ENOG4105D4A Cell wall formation (By similarity) AK39_5000 ENOG4108RE7 deoxyribonuclease AK39_5003 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AK39_5007 ENOG4105F6E Acyl-transferase AK39_501 ENOG41082W1 Cupin 2, conserved barrel domain protein AK39_5011 ENOG4105EGI Transcriptional regulator AK39_5014 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AK39_5015 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AK39_5016 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AK39_5017 ENOG4105E0C molybdate abc transporter AK39_5019 ENOG4107XDY Nicotinamide Mononucleotide Transporter AK39_502 ENOG4105Z7P Acetyltransferase (GNAT) family AK39_5020 ENOG4105II7 pyrroline-5-carboxylate reductase AK39_5022 ENOG4108J59 Extracellular solute-binding protein, family 5 AK39_5023 ENOG4108J59 Extracellular solute-binding protein, family 5 AK39_5029 ENOG4108JQ7 (ABC) transporter AK39_5030 ENOG4105C3U ABC transporter AK39_5031 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AK39_5032 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AK39_5035 ENOG4105C2C drug resistance transporter, Bcr CflA AK39_5038 ENOG4105IQ5 FAD linked oxidase domain protein AK39_5040 ENOG4105EE1 crotonyl-CoA reductase AK39_5041 ENOG4105D01 (LipO)protein AK39_5042 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AK39_5043 ENOG4108UMI ABC transporter, permease AK39_5044 ENOG4108PSK reductase AK39_5052 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AK39_5053 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AK39_5055 ENOG4105CMG Carbohydrate kinase AK39_5056 ENOG4105CMG Carbohydrate kinase AK39_5058 ENOG4108VQT Alpha beta hydrolase fold protein AK39_5059 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AK39_5061 ENOG4107U5W ybbr family AK39_5062 ENOG4105C8B TIGR00159 family AK39_5080 ENOG4108NMV polysaccharide deacetylase AK39_5083 ENOG4105D1F ATP-binding protein AK39_5088 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AK39_5089 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AK39_509 ENOG4105DC7 peptidase M24 AK39_5090 ENOG4108JJB ABC transporter AK39_5096 ENOG41067V7 50S ribosomal protein L36 AK39_5098 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AK39_51 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AK39_5100 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AK39_5105 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AK39_5126 ENOG4105XPM ribosomal protein AK39_5127 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AK39_5129 ENOG4107Y49 methyltransferase AK39_5134 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AK39_5136 ENOG4105QIV RNA polymerase AK39_5137 ENOG4105M0M Tetracycline resistance protein AK39_5138 ENOG4105C2N RNA methyltransferase TrmH family group 3 AK39_5141 ENOG4105D7W serine acetyltransferase AK39_5145 ENOG4105CTP PilT protein domain protein AK39_5147 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AK39_5150 ENOG4108Z0C Uvrb UvrC protein AK39_5157 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AK39_5159 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AK39_516 ENOG4105SFS phosphoesterase RecJ domain protein AK39_5160 ENOG4105KRF dihydroneopterin aldolase AK39_5161 ENOG4105EEI dihydropteroate synthase AK39_5162 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AK39_5163 ENOG4105DDQ anthranilate synthase AK39_5164 ENOG4105CRQ synthase (Component I) AK39_5165 ENOG4105C6T cysteine synthase AK39_5168 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AK39_5169 ENOG4108UGV hypoxanthine phosphoribosyltransferase AK39_5170 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AK39_5174 ENOG41060GV RNA binding s1 domain protein AK39_5177 ENOG4105VYY sporulation protein yabp AK39_5178 ENOG41082I2 s4 domain protein AK39_5179 ENOG4108IY2 MazG family AK39_518 ENOG4105VV2 AK39_5181 ENOG4108M14 stage v sporulation protein t AK39_5182 ENOG4108JA2 transcriptioN-repair coupling factor AK39_5184 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AK39_5185 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AK39_5188 ENOG4105KME endoribonuclease L-psp AK39_5189 ENOG4105DFT pur operon repressor AK39_519 ENOG4105C0B DNA polymerase III (alpha subunit) AK39_5192 ENOG4105W42 Veg protein AK39_5193 ENOG4105XFA sporulation peptidase YabG AK39_5195 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AK39_5196 ENOG4105F8V Hydrolase, tatD family AK39_5198 ENOG4105KRN Transcriptional regulator, abrb family AK39_5199 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AK39_520 ENOG4105C6K Malic enzyme AK39_5201 ENOG41060K3 Methyltransferase AK39_5203 ENOG4105MA4 psp1 domain protein AK39_5204 ENOG4105FA2 dna polymerase iii AK39_5206 ENOG4105CXN decarboxylase AK39_521 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AK39_5214 ENOG41067KS pro-sigma K processing AK39_5218 ENOG4105C6E dna polymerase iii AK39_5219 ENOG4108Z6B deaminase AK39_5220 ENOG4105GTG Isochorismatase AK39_5222 ENOG4105ZMH deoxynucleoside kinase AK39_5229 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AK39_5237 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AK39_5240 ENOG410848D S4 domain protein YaaA AK39_5241 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AK39_5245 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AK39_5247 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AK39_5251 ENOG4107QJE Chromosome Partitioning Protein AK39_5252 ENOG4105FA0 parb-like partition protein AK39_5253 ENOG4108ZDA Sporulation protein YyaC AK39_5254 ENOG4105D8X mechanosensitive ion channel AK39_5255 ENOG4105VDK protein, conserved in bacteria AK39_5256 ENOG4105C3G gtp-binding protein AK39_5258 ENOG4108UUM single-stranded DNA-binding protein AK39_526 ENOG4105FS0 cytoplasmic membrane protein AK39_5260 ENOG4108XMW Membrane AK39_5261 ENOG4105BZR domain protein AK39_5263 ENOG4105CDU Replicative dna helicase AK39_5269 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK39_527 ENOG4108REF Sporulation integral membrane protein ytvi AK39_5270 ENOG4105BZU Histidine kinase AK39_5273 ENOG4105Q2H domain protein AK39_5274 ENOG4105C0H protease AK39_5278 ENOG4105DPN Oligoendopeptidase f AK39_5281 ENOG4105C1J atp-dependent rna helicase AK39_5283 ENOG4108UT2 hemolysin iii AK39_5284 ENOG4105CMR udp-glucose 4-epimerase AK39_5286 ENOG4105IW1 AmiS UreI transporter AK39_5288 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AK39_529 ENOG4105BZN citrate synthase AK39_5291 ENOG4107RGD Major Facilitator superfamily AK39_5292 ENOG4108HRK Histidine kinase AK39_5293 ENOG4105DY9 regulatoR AK39_5296 ENOG4106F5Q Membrane AK39_5297 ENOG4105E0X reductase AK39_5299 ENOG41067SE Tetr family transcriptional regulator AK39_530 ENOG4108HMX isocitrate dehydrogenase (NADP) AK39_5300 ENOG4105CKK Glycosyl transferase, family 2 AK39_5305 ENOG4105C5H ABC transporter AK39_5306 ENOG4105JEU Glycosyl transferase, family 2 AK39_5308 ENOG4108S4H thioesterase Superfamily protein AK39_5310 ENOG4106YBV Methyl-accepting chemotaxis AK39_5311 ENOG4105EN6 Membrane AK39_5315 ENOG41079KZ Major Facilitator Superfamily AK39_5316 ENOG4105DY9 regulatoR AK39_5317 ENOG4105D22 carbon starvation protein AK39_5318 ENOG4105VCD cytoplasmic protein AK39_5319 ENOG4105BZU Histidine kinase AK39_5320 ENOG4105DWF phosphomethylpyrimidine kinase AK39_5321 ENOG4105BZU Histidine kinase AK39_5322 ENOG4105BZU Histidine kinase AK39_5323 ENOG4105WH1 Two component transcriptional regulator luxr family AK39_5325 ENOG4108Y4K DNA-binding transcriptional activator AK39_5330 ENOG4105D6E homoserine dehydrogenase AK39_5333 ENOG41090WU lipolytic protein G-D-S-L family AK39_5334 ENOG4105CJ1 ABC, transporter AK39_5335 ENOG4108TU7 Inherit from COG: (ABC) transporter AK39_5337 ENOG4105VCH membrane AK39_5338 ENOG410667J hydrolase AK39_534 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK39_5340 ENOG4107SVH Potassium channel protein AK39_5344 ENOG4108VKI Cell wall hydrolase AK39_5347 ENOG4108IJ2 phosphate acetyltransferase AK39_535 ENOG4105BZU Histidine kinase AK39_5350 ENOG4108VCI transcription factor, rsfa family AK39_5352 ENOG4105DQ5 transport system permease protein AK39_5353 ENOG4105DQ5 transport system permease protein AK39_5354 ENOG4105EHG Permease protein AK39_5355 ENOG4105E0A ABC, transporter AK39_5356 ENOG4108MES Periplasmic binding protein AK39_5357 ENOG4105DCI Phosphohydrolase AK39_5358 ENOG41069HH 4-oxalocrotonate tautomerase AK39_5359 ENOG4108Z4T Peptidase M50 AK39_536 ENOG4105C2M dna polymerase I AK39_5360 ENOG4108XFG YwhD family AK39_5361 ENOG4105BZ4 penicillin-binding protein AK39_5362 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AK39_5363 ENOG4107SWG transcriptional regulator MERR family AK39_5364 ENOG4105DXB Major Facilitator superfamily AK39_5366 ENOG4105CYW agmatinase AK39_537 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AK39_5370 ENOG410684U Domain of unknown function (DUF1934) AK39_5372 ENOG4105EMN RNA polymerase sigma factor AK39_5376 ENOG4105IIU Aminopeptidase AK39_5380 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AK39_5381 ENOG4108M15 ABC transporter AK39_5382 ENOG4105KCT ABC transporter AK39_5383 ENOG4105BZU Histidine kinase AK39_5388 ENOG4105BZU Histidine kinase AK39_539 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AK39_5391 ENOG4105DF6 Fe-S oxidoreductase AK39_5393 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AK39_5394 ENOG4105C1G acyl-Coa dehydrogenase AK39_5395 ENOG4105C1G acyl-Coa dehydrogenase AK39_54 ENOG4105KVH Transcriptional regulator AK39_540 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AK39_5402 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AK39_5403 ENOG4105CBT Fructose-1,6-bisphosphatase AK39_5404 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AK39_5407 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AK39_5408 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AK39_5409 ENOG4108ZXQ stage ii sporulation protein r AK39_541 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AK39_5411 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AK39_5414 ENOG4107XC4 flavin reductase domain protein, FMN-binding AK39_5415 ENOG4108VGI doxx family AK39_5418 ENOG4108YZG isomerase AK39_5423 ENOG41062M3 atp synthase AK39_5424 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AK39_5434 ENOG4105BZU Histidine kinase AK39_5435 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AK39_5437 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AK39_5438 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AK39_5443 ENOG4105D65 subunit l AK39_5444 ENOG4105C8S subunit m AK39_5445 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AK39_5446 ENOG4106778 Protein of unknown function (DUF1146) AK39_545 ENOG4108TDW sporulation protein YtxC AK39_5450 ENOG4108IUW ABC transporter AK39_5451 ENOG4105DY9 regulatoR AK39_5454 ENOG4105FRN stage II sporulation protein AK39_5456 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AK39_546 ENOG4105C22 threonyL-tRNA synthetase AK39_5467 ENOG4105EY8 ABC transporter AK39_5468 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AK39_547 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AK39_5471 ENOG4105CMR udp-glucose 4-epimerase AK39_5472 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK39_5473 ENOG4105BZU Histidine kinase AK39_5476 ENOG4105CXY transporter AK39_5480 ENOG4105C19 ABC transporter AK39_5481 ENOG4107RBB ABC transporter, permease AK39_5483 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK39_5489 ENOG4105C0D helicase AK39_5490 ENOG4105KBK Zinc finger, swim domain protein AK39_5495 ENOG41069ER domain protein AK39_5496 ENOG4105C94 Transporter AK39_55 ENOG4105F27 Major Facilitator AK39_5505 ENOG4105E0M Sulfatase AK39_5508 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AK39_551 ENOG4105CN9 Peptidase m42 family protein AK39_5510 ENOG4105DAA L-lactate AK39_5518 ENOG4107RSM transcriptional regulator AK39_5519 ENOG4105ECB domain protein AK39_552 ENOG4108JGH Tetr family transcriptional regulator AK39_5520 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AK39_5523 ENOG4105VZJ PTS System AK39_5525 ENOG4105VCP PTS System AK39_5526 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AK39_5527 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AK39_5529 ENOG4105CK1 PTS System AK39_553 ENOG4105CW7 secretion protein, HlyD family AK39_5530 ENOG4105VCP PTS System AK39_5531 ENOG4105F8D glycoside hydrolase family 4 AK39_5532 ENOG410901P UPF0249 protein AK39_5535 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AK39_5537 ENOG4105ESV Glycosyl transferase, family 4 AK39_5538 ENOG4105C6Y Udp-glucose 6-dehydrogenase AK39_5539 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AK39_554 ENOG4105C0R drug resistance transporter emrb qaca subfamily AK39_5540 ENOG4108KGH TRANSCRIPTIONal AK39_5541 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AK39_5543 ENOG4105KVH Transcriptional regulator AK39_5546 ENOG41081UC Inherit from COG: Competence protein AK39_5547 ENOG4105VEQ Cold shock protein AK39_5548 ENOG4105MS2 ribosomal subunit Interface protein AK39_5549 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AK39_5550 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AK39_5552 ENOG4105CAK Cell division ATP-binding protein ftsE AK39_5553 ENOG4105CRP Part of the ABC transporter FtsEX involved in AK39_5554 ENOG4105CN1 protease AK39_5556 ENOG4105BZ1 (ABC) transporter AK39_5559 ENOG4108WS4 fmn reductase AK39_5561 ENOG4105DUM transcriptional regulator, lysR family AK39_5562 ENOG4105HMI Membrane AK39_5566 ENOG4107TXC Transcriptional regulator AK39_5569 ENOG4105D7V transposase AK39_5570 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AK39_5571 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AK39_5573 ENOG41086DT Membrane protein of unknown function AK39_5577 ENOG4108S4C acetyltransferase AK39_5579 ENOG4105C3M thioredoxin reductase AK39_5581 ENOG4108Z4K mutator MutT protein AK39_5583 ENOG4105CHW UPF0052 protein AK39_5585 ENOG4105KRI phosphocarrier protein (HPr AK39_5586 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AK39_5587 ENOG4105H67 Protein of unknown function (DUF421) AK39_5590 ENOG4105CZ3 stage V sporulation protein ad AK39_5591 ENOG41090VF Stage v sporulation protein ac AK39_5595 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK39_56 ENOG4105CV8 reductase AK39_5603 ENOG4105EKQ RNA-directed DNA polymerase AK39_561 ENOG4108RWN rrna methyltransferase AK39_5615 ENOG4106JUT Streptomycin 3''-adenylyltransferase AK39_5629 ENOG4105CNU cell division protein FtsK AK39_563 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AK39_564 ENOG4105C5S asparaginyl-tRNA synthetase AK39_5680 ENOG4105DHF Membrane AK39_5686 ENOG4106AKK s-layer domain-containing protein AK39_5687 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AK39_5691 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AK39_5692 ENOG4105C6Y Udp-glucose 6-dehydrogenase AK39_5696 ENOG4105DQ6 Transposase AK39_571 ENOG4105DCG PHP domain protein AK39_5730 ENOG4105KRN Transcriptional regulator, abrb family AK39_5732 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AK39_5739 ENOG4108IBT Inherit from COG: transposase AK39_574 ENOG4105FE9 pseudouridine synthase AK39_5741 ENOG4105DQ6 Transposase AK39_5745 ENOG4105DQ6 Transposase AK39_5747 ENOG4108MEK Metal-binding protein YodA AK39_5749 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AK39_5756 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AK39_576 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AK39_5777 ENOG4105EKQ RNA-directed DNA polymerase AK39_578 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AK39_581 ENOG4105E0A ABC, transporter AK39_582 ENOG4105KFN sortase, SrtB family AK39_585 ENOG4105DR4 Methyltransferase AK39_588 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK39_597 ENOG4105S6R Iron-hydroxamate transporter permease subunit AK39_598 ENOG4105J76 Periplasmic binding protein AK39_600 ENOG4105CEY Amp-dependent synthetase and ligase AK39_601 ENOG4107Z3H Transcriptional regulator, TetR family AK39_602 ENOG41060WC Enoyl-CoA hydratase AK39_603 ENOG4105BZJ Electron transfer flavoprotein AK39_604 ENOG4105C10 Electron transfer flavoprotein AK39_605 ENOG4105K63 Thioredoxin AK39_608 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AK39_61 ENOG4108RYK Nad-dependent epimerase dehydratase AK39_610 ENOG4105E33 succinate dehydrogenase AK39_612 ENOG4108VXD carboxy-peptidase AK39_613 ENOG4105E14 MotA TolQ exbB proton channel AK39_614 ENOG4105ER2 Ompa motb domain protein AK39_615 ENOG4105ER2 Ompa motb domain protein AK39_616 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AK39_617 ENOG4108IUX (ABC) transporter AK39_618 ENOG4105RHA ABC transporter, permease AK39_619 ENOG4108Z40 Transcriptional regulator AK39_620 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AK39_622 ENOG4108JCI Transcriptional regulator AK39_623 ENOG41067S9 phage shock protein C, PspC AK39_626 ENOG4105DY9 regulatoR AK39_627 ENOG4108HRK Histidine kinase AK39_628 ENOG4108JQ7 (ABC) transporter AK39_631 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AK39_632 ENOG4105DEF Extracellular solute-binding protein, family 5 AK39_633 ENOG4105DZC cytosine deaminase AK39_634 ENOG4105DZC cytosine deaminase AK39_637 ENOG4105PFC Transcriptional regulator AK39_64 ENOG4105D9N nucleoside AK39_640 ENOG4105KBX Transcriptional regulator, TetR family AK39_642 ENOG4108PCX Major Facilitator AK39_644 ENOG4108XJQ germination protein AK39_646 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AK39_647 ENOG4105M59 Phosphodiesterase, mj0936 family AK39_65 ENOG4105D9N nucleoside AK39_651 ENOG4108QCI YvbH-like oligomerisation region AK39_657 ENOG4108IUQ atp-dependent protease AK39_661 ENOG4105K56 Transcriptional regulator AK39_666 ENOG4105D52 delta-aminolevulinic acid dehydratase AK39_668 ENOG41068KH stage VI sporulation protein D AK39_670 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AK39_671 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AK39_675 ENOG4105DFF Rod shape-determining protein mreb AK39_676 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AK39_679 ENOG4107QMS site-determining protein AK39_682 ENOG4105C03 ribonuclease AK39_684 ENOG4105X36 (ribosomal) protein AK39_687 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AK39_690 ENOG4105EWM Histidine kinase AK39_694 ENOG4105CQC Prephenate dehydratase AK39_695 ENOG4108RPX mosc domain containing protein AK39_698 ENOG4108IYU L-aspartate oxidase AK39_699 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AK39_70 ENOG4108URH decarboxylase AK39_704 ENOG41082BM Transcriptional regulator, arsr family AK39_705 ENOG4108IPJ Membrane AK39_706 ENOG4108IPJ Membrane AK39_708 ENOG4108HUF Transporter AK39_711 ENOG41061AI Protein of unknown function (DUF2905) AK39_714 ENOG4105VIE preprotein translocase, subunit YajC AK39_716 ENOG4108QG2 Membrane AK39_717 ENOG4105CKP Polysaccharide Biosynthesis Protein AK39_719 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AK39_720 ENOG41076HS cation diffusion facilitator family transporter AK39_721 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AK39_723 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AK39_726 ENOG4105CUT histidyl-tRNA synthetase AK39_728 ENOG4105CUZ uba thif-type nad fad binding protein AK39_729 ENOG4108VCI transcription factor, rsfa family AK39_73 ENOG4108RMU ferritin dps family protein AK39_730 ENOG4105D1H recombination factor protein RarA AK39_732 ENOG4105C3J Cysteine desulfurase AK39_733 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AK39_735 ENOG4105C7H Helicase, RecD TraA family AK39_736 ENOG41060CR AK39_739 ENOG4105C02 permease AK39_741 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AK39_745 ENOG4105HHA aminodeoxychorismate lyase AK39_746 ENOG4108VQJ O-methyltransferase AK39_747 ENOG4105XYU peptidase (U32 family) AK39_748 ENOG4105CFP Peptidase U32 AK39_75 ENOG4105NCW Trka-c domain protein AK39_751 ENOG4107XRG penicillin-binding protein AK39_757 ENOG4105C28 cystathionine AK39_758 ENOG4108EKI Dehydrogenase AK39_76 ENOG4107S91 Sodium hydrogen exchanger AK39_760 ENOG4108V5C ABC transporter AK39_761 ENOG4105S6R Iron-hydroxamate transporter permease subunit AK39_769 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AK39_770 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AK39_772 ENOG4105MIR Phenylalanine 4-monooxygenase AK39_773 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AK39_780 ENOG4108MUZ hydrolase AK39_782 ENOG4105G6Z alkaline phosphatase AK39_785 ENOG4108TVJ Nitroreductase AK39_790 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK39_793 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AK39_794 ENOG4105CQW ribosome biogenesis GTPase YqeH AK39_796 ENOG410812S Rna-binding protein AK39_798 ENOG4108WF2 Metal Dependent Phosphohydrolase AK39_80 ENOG4105D4Y metalloprotease AK39_800 ENOG4105DXX methyltransferase AK39_802 ENOG4105KQC Competence protein AK39_803 ENOG4108UK2 deaminase AK39_807 ENOG4105TQK DNA polymerase iii, delta' subunit AK39_81 ENOG4105VG1 fes assembly suf system protein AK39_812 ENOG4105KVH Transcriptional regulator AK39_813 ENOG4105CSA Coproporphyrinogen iii oxidase AK39_815 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AK39_819 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AK39_820 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AK39_822 ENOG4105KTH gatB Yqey AK39_823 ENOG41068P3 sporulation protein YqfC AK39_825 ENOG4105C9A Phoh family AK39_826 ENOG4105CTJ Metal Dependent Phosphohydrolase AK39_828 ENOG4107YR5 Diacylglycerol kinase AK39_829 ENOG4105KG3 cytidine deaminase AK39_830 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AK39_835 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AK39_836 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK39_839 ENOG4105EGD dinuclear metal center protein, YbgI family AK39_84 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AK39_844 ENOG41069ZM Protein of unknown function (DUF2624) AK39_845 ENOG4108JYZ YitT family AK39_846 ENOG4105FDK ABC transporter AK39_848 ENOG4105N80 Ferric uptake regulator, Fur family AK39_853 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AK39_855 ENOG4107RF6 penicillin-binding protein AK39_856 ENOG4105PWN phosphate abc transporter AK39_857 ENOG4105C8U phosphate abc transporter AK39_858 ENOG4105E2Z phosphate ABC transporter (Permease AK39_859 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AK39_86 ENOG4105BZU Histidine kinase AK39_860 ENOG4108UTW Plays a role in the regulation of phosphate uptake AK39_863 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AK39_865 ENOG4105DKQ ROK family AK39_867 ENOG4105C5X domain protein AK39_87 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK39_871 ENOG4105C28 cystathionine AK39_872 ENOG4105C28 cystathionine AK39_874 ENOG4105C3R Methionine synthase AK39_875 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AK39_88 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AK39_899 ENOG4105C0D helicase AK39_90 ENOG4107ZTW SNARE associated Golgi AK39_905 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AK39_906 ENOG4105CJ1 ABC, transporter AK39_913 ENOG41080TC multidrug resistance protein AK39_917 ENOG4105WZW rhodanese family AK39_918 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AK39_923 ENOG4107YBY Hydrolase AK39_924 ENOG4105CBJ Metal-dependent enzyme AK39_927 ENOG4105DC7 peptidase M24 AK39_932 ENOG4105CD2 stage iii sporulation protein aa AK39_933 ENOG4105KR5 Stage iii sporulation protein AK39_934 ENOG4108CQH stage III sporulation protein AC AK39_935 ENOG4105KQ4 Stage iii sporulation protein ad AK39_937 ENOG410644B Stage III sporulation protein af AK39_942 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AK39_943 ENOG4108ZSR alkaline shock protein AK39_948 ENOG4105CTB Polyprenyl synthetase AK39_950 ENOG4105DX0 Hemolysin A AK39_952 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AK39_953 ENOG4105S1Z Stage IV sporulation protein B AK39_954 ENOG4107QQR Sporulation AK39_957 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AK39_959 ENOG4108JUB Transcriptional regulator AK39_961 ENOG4107RDP Dehydrogenase AK39_965 ENOG4105CPP Dehydrogenase, E1 component AK39_966 ENOG4105C7S Dehydrogenase AK39_968 ENOG4105E09 nadh pyrophosphatase AK39_969 ENOG4105G7B Protein of unknown function (DUF2992) AK39_97 ENOG4107AYK membrAne AK39_971 ENOG4108HW3 (ABC) transporter AK39_972 ENOG4105E5Q amino acid AbC transporter AK39_973 ENOG4105CDA abc transporter atp-binding protein AK39_974 ENOG4108QEG Membrane AK39_975 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AK39_977 ENOG4105D9U N-acetyltransferase AK39_978 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AK39_980 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AK39_984 ENOG4105EJQ L-serine dehydratase AK39_985 ENOG4105II7 pyrroline-5-carboxylate reductase AK39_987 ENOG41069FQ Metallo-beta-lactamase superfamily AK39_988 ENOG4108IXY short-chain dehydrogenase reductase AK39_99 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AK39_991 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AK39_999 ENOG4105CGH 5'-nucleotidase