locus-tag	class	description
AK39_10	COG4695	Portal protein
AK39_1002	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AK39_1004	COG0156	8-amino-7-oxononanoate synthase activity
AK39_1005	COG1073	alpha beta
AK39_1005	COG2226	methyltransferase
AK39_1006	COG4106	trans-aconitate 2-methyltransferase activity
AK39_1007	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AK39_101	COG0531	amino acid
AK39_1011	COG0307	riboflavin synthase, alpha
AK39_1012	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AK39_1012	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AK39_1015	COG1073	alpha beta
AK39_1016	COG0456	acetyltransferase
AK39_1017	COG1609	Transcriptional regulator
AK39_1018	COG2056	Na+-H+ antiporter family
AK39_1019	COG0596	Alpha beta hydrolase
AK39_102	COG2814	Major facilitator Superfamily
AK39_1021	COG4085	toxin activity
AK39_1021	COG1525	nuclease
AK39_1021	COG0737	Belongs to the 5'-nucleotidase family
AK39_1023	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK39_1023	COG0456	acetyltransferase
AK39_1024	COG0656	L-ascorbic acid biosynthetic process
AK39_1025	COG0667	Aldo Keto reductase
AK39_1029	COG1300	Membrane
AK39_1030	COG0735	belongs to the Fur family
AK39_1032	COG4974	Belongs to the 'phage' integrase family
AK39_1037	COG0598	Magnesium transport protein CorA
AK39_1040	COG1846	Transcriptional regulator
AK39_1043	COG1131	(ABC) transporter
AK39_1044	COG1725	Transcriptional regulator
AK39_1045	COG1686	Belongs to the peptidase S11 family
AK39_1049	COG0733	neurotransmitter:sodium symporter activity
AK39_1054	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK39_1057	COG0697	spore germination
AK39_1058	COG0561	phosphatase activity
AK39_1059	COG4086	secreted protein
AK39_106	COG0840	transmembrane signaling receptor activity
AK39_1060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AK39_1061	COG0456	acetyltransferase
AK39_1062	COG1547	Domain of unknown function (DUF309)
AK39_1067	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AK39_107	COG0011	TIGRFAM Protein of
AK39_1071	COG3711	transcriptional antiterminator
AK39_1072	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK39_1072	COG1263	PTS System
AK39_1072	COG2190	(PTS) system
AK39_1077	COG0778	Nitroreductase
AK39_1078	COG3706	GGDEF domain
AK39_1079	COG2084	Dehydrogenase
AK39_1080	COG2084	Dehydrogenase
AK39_1083	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AK39_1087	COG0436	Aminotransferase
AK39_1088	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AK39_1092	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_1093	COG1695	Transcriptional regulator
AK39_110	COG1686	Belongs to the peptidase S11 family
AK39_1100	COG0183	Belongs to the thiolase family
AK39_1108	COG3842	ATPase activity
AK39_1109	COG0366	Alpha amylase catalytic
AK39_1111	COG2182	Extracellular solute-binding protein
AK39_1112	COG1175	transmembrane transport
AK39_1113	COG3833	ABC-type maltose transport systems, permease component
AK39_1114	COG1609	Transcriptional regulator
AK39_1115	COG0436	Aminotransferase
AK39_1117	COG2205	protein histidine kinase activity
AK39_1119	COG3209	COG3209 Rhs family protein
AK39_112	COG1250	3-hydroxyacyl-CoA dehydrogenase
AK39_112	COG1024	Enoyl-CoA hydratase
AK39_1123	COG2814	Major facilitator Superfamily
AK39_113	COG0183	Belongs to the thiolase family
AK39_1130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AK39_1132	COG1408	metallophosphoesterase
AK39_1133	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_1134	COG2200	EAL domain
AK39_1137	COG4703	Protein of unknown function (DUF1797)
AK39_1139	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AK39_114	COG1960	acyl-CoA dehydrogenase activity
AK39_1141	COG0517	IMP dehydrogenase activity
AK39_1142	COG0583	DNA-binding transcription factor activity
AK39_1146	COG0569	domain protein
AK39_1147	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AK39_1149	COG0561	phosphatase activity
AK39_115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_1150	COG0242	peptide deformylase activity
AK39_1152	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AK39_1153	COG0022	dehydrogenase e1 component
AK39_1154	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK39_116	COG1309	transcriptional regulator
AK39_1163	COG1982	Orn Lys Arg decarboxylase major
AK39_1167	COG0483	inositol monophosphate 1-phosphatase activity
AK39_1172	COG4896	Protein conserved in bacteria
AK39_1174	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AK39_1175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AK39_1176	COG4838	Belongs to the UPF0358 family
AK39_1177	COG0772	Belongs to the SEDS family
AK39_1178	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AK39_1185	COG3336	cytochrome c oxidase
AK39_1188	COG2340	Cysteine-rich secretory protein family
AK39_1191	COG0406	alpha-ribazole phosphatase activity
AK39_1192	COG3679	Belongs to the UPF0342 family
AK39_1196	COG0742	ribosomal rna small subunit methyltransferase
AK39_1197	COG3314	Sporulation integral membrane protein YlbJ
AK39_1199	COG1752	Esterase of the alpha-beta hydrolase superfamily
AK39_1200	COG3480	Lon protease (S16) C-terminal proteolytic domain
AK39_1202	COG0582	viral genome integration into host DNA
AK39_1206	COG1396	sequence-specific DNA binding
AK39_121	COG0039	L-malate dehydrogenase activity
AK39_1210	COG1396	sequence-specific DNA binding
AK39_1216	COG1484	DNA-dependent DNA replication
AK39_1221	COG1191	sigma factor activity
AK39_1236	COG0582	viral genome integration into host DNA
AK39_1241	COG1802	Transcriptional regulator
AK39_1241	COG4626	Terminase
AK39_1260	COG4824	toxin secretion phage lysis holin
AK39_1270	COG1399	metal-binding, possibly nucleic acid-binding protein
AK39_1274	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AK39_1277	COG4839	cell division protein FtsL
AK39_1279	COG0768	penicillin binding
AK39_1280	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AK39_1283	COG0772	Belongs to the SEDS family
AK39_1284	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AK39_1285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AK39_1286	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AK39_1287	COG0849	cell division
AK39_1288	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AK39_1290	COG1191	sigma factor activity
AK39_1291	COG1191	sigma factor activity
AK39_1292	COG1873	PFAM PRC-barrel domain
AK39_1294	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AK39_1296	COG0762	integral membrane protein
AK39_1297	COG2302	S4 RNA-binding domain
AK39_1298	COG3599	regulation of cell shape
AK39_1299	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AK39_130	COG1393	Belongs to the ArsC family
AK39_1302	COG0564	pseudouridine synthase activity
AK39_1307	COG0505	Belongs to the CarA family
AK39_1315	COG3069	C4-dicarboxylate transmembrane transporter activity
AK39_1318	COG0006	proline dipeptidase activity
AK39_132	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AK39_1320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AK39_1321	COG1561	YicC-like family, N-terminal region
AK39_1323	COG0194	GDP metabolic process
AK39_1325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AK39_1326	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AK39_1327	COG0242	peptide deformylase activity
AK39_1329	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AK39_1329	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AK39_133	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK39_1331	COG0631	protein serine/threonine phosphatase activity
AK39_1332	COG2815	serine threonine protein kinase
AK39_1332	COG0515	serine threonine protein kinase
AK39_1333	COG1162	GTPase activity
AK39_1334	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AK39_1335	COG1564	THIamine pyrophosphokinase
AK39_1337	COG1302	Protein conserved in bacteria
AK39_1338	COG1461	Dihydroxyacetone kinase
AK39_1339	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AK39_1342	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AK39_1343	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_1346	COG1196	nuclear chromosome segregation
AK39_1347	COG0552	protein localization to endoplasmic reticulum
AK39_1349	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AK39_135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AK39_1351	COG1837	Belongs to the UPF0109 family
AK39_1359	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AK39_136	COG2011	ABC-type metal ion transport system permease component
AK39_1361	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AK39_1363	COG4974	Belongs to the 'phage' integrase family
AK39_1369	COG0528	UMP kinase activity
AK39_137	COG1464	Belongs to the NlpA lipoprotein family
AK39_1371	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AK39_1372	COG4589	Belongs to the CDS family
AK39_1373	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AK39_1374	COG0750	zinc metalloprotease
AK39_1378	COG0195	Participates in both transcription termination and antitermination
AK39_1379	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AK39_138	COG1464	Belongs to the NlpA lipoprotein family
AK39_1380	COG1358	cellular component organization or biogenesis
AK39_1382	COG1550	Protein conserved in bacteria
AK39_1384	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AK39_1385	COG0196	riboflavin kinase activity
AK39_1388	COG0726	polysaccharide deacetylase
AK39_1389	COG0612	Peptidase, M16
AK39_139	COG0396	ATPase activity
AK39_1390	COG1873	PFAM PRC-barrel domain
AK39_1391	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AK39_1392	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AK39_1393	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AK39_1394	COG0527	aspartate kinase activity
AK39_1396	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AK39_1397	COG0740	serine-type endopeptidase activity
AK39_1399	COG1674	ftsk spoiiie
AK39_140	COG0719	Fe-S assembly protein
AK39_1400	COG2188	Transcriptional regulator
AK39_1406	COG0612	Peptidase, M16
AK39_1407	COG0612	Peptidase, M16
AK39_1408	COG0300	oxidoreductase activity
AK39_141	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AK39_1411	COG1426	Protein conserved in bacteria
AK39_1412	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AK39_1417	COG1692	metallophosphoesterase
AK39_1418	COG2359	stage V sporulation protein S
AK39_142	COG0822	iron-sulfur transferase activity
AK39_1420	COG0674	pyruvate-flavodoxin oxidoreductase activity
AK39_1420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AK39_1421	COG1013	pyruvate-flavodoxin oxidoreductase activity
AK39_1422	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AK39_1423	COG4550	Control of competence regulator ComK, YlbF/YmcA
AK39_143	COG0719	Fe-S assembly protein
AK39_1432	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AK39_1434	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AK39_1435	COG1368	sulfuric ester hydrolase activity
AK39_1436	COG0562	UDP-galactopyranose mutase
AK39_1437	COG3773	Cell wall hydrolase
AK39_1438	COG1404	Belongs to the peptidase S8 family
AK39_1441	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AK39_1442	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK39_1442	COG0596	Alpha beta hydrolase
AK39_1443	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_1444	COG1380	Effector of murein hydrolase LrgA
AK39_1445	COG1346	cytolysis
AK39_1448	COG5001	Diguanylate cyclase
AK39_1448	COG3300	MHYT domain
AK39_1449	COG0346	lactoylglutathione lyase activity
AK39_145	COG1695	Transcriptional regulator
AK39_1450	COG2267	carboxylic ester hydrolase activity
AK39_1453	COG2364	Membrane
AK39_1455	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AK39_1456	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AK39_1457	COG2169	Transcriptional regulator
AK39_1458	COG0708	Exodeoxyribonuclease III
AK39_146	COG0737	Belongs to the 5'-nucleotidase family
AK39_1460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_1461	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_1462	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_1463	COG1120	ATPase activity
AK39_1464	COG2819	hydrolase of the alpha beta superfamily
AK39_1466	COG1937	Protein conserved in bacteria
AK39_1467	COG2608	mercury ion transmembrane transporter activity
AK39_1468	COG2217	Heavy metal translocating P-type atpase
AK39_147	COG3377	Domain of unknown function (DUF1805)
AK39_1470	COG2116	formate transmembrane transporter activity
AK39_1471	COG1408	metallophosphoesterase
AK39_1474	COG1113	amino acid transport
AK39_1477	COG2322	membrane
AK39_1478	COG1979	alcohol dehydrogenase
AK39_1479	COG1979	alcohol dehydrogenase
AK39_1480	COG1349	DNA-binding transcription factor activity
AK39_1481	COG1105	Belongs to the carbohydrate kinase PfkB family
AK39_1482	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AK39_1482	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AK39_1482	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AK39_1483	COG1388	LysM domain
AK39_1483	COG3584	3D domain protein
AK39_149	COG0739	heme binding
AK39_1490	COG0464	growth
AK39_1491	COG2860	membrane
AK39_1492	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AK39_1493	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AK39_1494	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AK39_1495	COG0789	Transcriptional regulator
AK39_1496	COG0174	glutamine synthetase
AK39_1501	COG1396	sequence-specific DNA binding
AK39_1517	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AK39_1525	COG1595	DNA-templated transcription, initiation
AK39_154	COG4377	Putative membrane peptidase family (DUF2324)
AK39_155	COG0789	Transcriptional regulator
AK39_1557	COG4824	toxin secretion phage lysis holin
AK39_1558	COG5632	N-Acetylmuramoyl-L-alanine amidase
AK39_1558	COG3409	Peptidoglycan-binding domain 1 protein
AK39_1558	COG1388	LysM domain
AK39_1566	COG1695	Transcriptional regulator
AK39_157	COG4470	Protein conserved in bacteria
AK39_1570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AK39_1572	COG0737	Belongs to the 5'-nucleotidase family
AK39_1575	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AK39_1576	COG3639	organic phosphonate transmembrane transporter activity
AK39_1582	COG1132	(ABC) transporter
AK39_1583	COG1132	(ABC) transporter
AK39_1586	COG5632	N-Acetylmuramoyl-L-alanine amidase
AK39_1586	COG3409	Peptidoglycan-binding domain 1 protein
AK39_1588	COG0730	response to heat
AK39_1591	COG1346	cytolysis
AK39_1592	COG1380	Effector of murein hydrolase LrgA
AK39_1593	COG0583	DNA-binding transcription factor activity
AK39_1595	COG0785	Cytochrome C biogenesis protein
AK39_1596	COG4846	Membrane protein involved in cytochrome C biogenesis
AK39_160	COG1494	fructose-1,6-bisphosphatase
AK39_1606	COG2226	methyltransferase
AK39_161	COG2445	Protein of unknown function DUF86
AK39_1611	COG0010	Belongs to the arginase family
AK39_1612	COG1329	Transcriptional regulator
AK39_1613	COG1902	pentaerythritol trinitrate reductase activity
AK39_1614	COG0069	glutamate synthase activity
AK39_1615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK39_1616	COG0346	lactoylglutathione lyase activity
AK39_1617	COG0400	carboxylic ester hydrolase activity
AK39_1618	COG5002	protein histidine kinase activity
AK39_1620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_1629	COG0318	PFAM AMP-dependent synthetase and ligase
AK39_163	COG0647	UMP catabolic process
AK39_1630	COG1268	BioY protein
AK39_1631	COG0318	PFAM AMP-dependent synthetase and ligase
AK39_1632	COG0183	Belongs to the thiolase family
AK39_1635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AK39_1637	COG2211	Major facilitator Superfamily
AK39_164	COG2249	NAD(P)H dehydrogenase (quinone) activity
AK39_1640	COG0726	polysaccharide deacetylase
AK39_1642	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AK39_1643	COG2274	protein secretion by the type I secretion system
AK39_1645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK39_1651	COG0824	Thioesterase
AK39_1652	COG4841	protein insertion into membrane
AK39_1653	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AK39_1656	COG0745	RESPONSE REGULATOR receiver
AK39_1657	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AK39_1658	COG1832	CoA-binding protein
AK39_1659	COG0187	DNA topoisomerase II activity
AK39_166	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AK39_1660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AK39_1661	COG0673	inositol 2-dehydrogenase activity
AK39_1663	COG1131	(ABC) transporter
AK39_1667	COG1595	DNA-templated transcription, initiation
AK39_1669	COG1316	TRANSCRIPTIONal
AK39_167	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AK39_1670	COG1301	dicarboxylic acid transport
AK39_1671	COG4166	transmembrane transport
AK39_1672	COG4166	transmembrane transport
AK39_1673	COG4166	transmembrane transport
AK39_1674	COG2226	methyltransferase
AK39_1682	COG0697	spore germination
AK39_1684	COG3383	formate dehydrogenase (NAD+) activity
AK39_1685	COG2427	Protein of unknown function (DUF1641)
AK39_1686	COG5609	conserved protein (DUF2294)
AK39_1687	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AK39_1689	COG2116	formate transmembrane transporter activity
AK39_169	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AK39_1690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK39_1691	COG0303	'Molybdopterin
AK39_1692	COG0314	molybdopterin synthase activity
AK39_1694	COG0489	protein tyrosine kinase activity
AK39_1697	COG3326	Membrane
AK39_1698	COG2962	Rard protein
AK39_1699	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AK39_170	COG4837	Protein of unknown function (DUF1462)
AK39_1700	COG1657	PFAM Prenyltransferase squalene oxidase
AK39_1702	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_1703	COG1012	belongs to the aldehyde dehydrogenase family
AK39_1705	COG4145	pantothenate transmembrane transporter activity
AK39_1708	COG0165	Argininosuccinate lyase
AK39_1710	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_1716	COG0716	FMN binding
AK39_1718	COG1278	Cold shock
AK39_1724	COG2720	vancomycin resistance protein
AK39_1725	COG2514	catechol 2,3-dioxygenase activity
AK39_1727	COG1285	pathogenesis
AK39_1729	COG1024	Enoyl-CoA hydratase
AK39_1730	COG1216	Glycosyl transferase, family 2
AK39_1736	COG0277	FAD linked oxidase domain protein
AK39_1737	COG0385	Bile acid
AK39_1739	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK39_1740	COG2808	Putative FMN-binding domain
AK39_1743	COG0457	Tetratricopeptide repeat
AK39_1745	COG0604	alcohol dehydrogenase
AK39_1746	COG0640	Transcriptional regulator
AK39_1750	COG0584	glycerophosphoryl diester phosphodiesterase
AK39_1756	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK39_1757	COG1164	Oligoendopeptidase f
AK39_1758	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AK39_1761	COG1193	negative regulation of DNA recombination
AK39_1765	COG0583	DNA-binding transcription factor activity
AK39_1771	COG0384	phenazine biosynthesis protein PhzF
AK39_1772	COG3739	integral membrane protein
AK39_1773	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_1774	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_1776	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_178	COG2824	Alkylphosphonate utilization operon protein PhnA
AK39_1780	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AK39_1781	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AK39_1787	COG2814	Major facilitator Superfamily
AK39_1788	COG1113	amino acid transport
AK39_1789	COG0604	alcohol dehydrogenase
AK39_179	COG0390	transport system, permease component
AK39_1796	COG2072	flavoprotein involved in K transport
AK39_1803	COG3409	Peptidoglycan-binding domain 1 protein
AK39_1803	COG3757	hydrolase, family 25
AK39_1804	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_1807	COG1151	hydroxylamine reductase activity
AK39_181	COG1252	NADH dehydrogenase
AK39_1812	COG3152	Membrane
AK39_1816	COG1309	transcriptional regulator
AK39_1819	COG1191	sigma factor activity
AK39_1822	COG0726	polysaccharide deacetylase
AK39_1826	COG1733	regulation of RNA biosynthetic process
AK39_1827	COG2249	NAD(P)H dehydrogenase (quinone) activity
AK39_1829	COG0318	PFAM AMP-dependent synthetase and ligase
AK39_1831	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_1833	COG0384	phenazine biosynthesis protein PhzF
AK39_1837	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_184	COG0316	Belongs to the HesB IscA family
AK39_1840	COG1733	regulation of RNA biosynthetic process
AK39_1841	COG1733	regulation of RNA biosynthetic process
AK39_1842	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AK39_1844	COG0673	inositol 2-dehydrogenase activity
AK39_1845	COG2188	Transcriptional regulator
AK39_1846	COG1733	regulation of RNA biosynthetic process
AK39_1847	COG1393	Belongs to the ArsC family
AK39_1852	COG0814	amino acid
AK39_1853	COG0346	lactoylglutathione lyase activity
AK39_1856	COG2814	Major facilitator Superfamily
AK39_1857	COG0656	L-ascorbic acid biosynthetic process
AK39_1862	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_1865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AK39_1866	COG0604	alcohol dehydrogenase
AK39_1867	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AK39_1868	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AK39_187	COG1683	Conserved Protein
AK39_1870	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AK39_1871	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AK39_1873	COG1070	Carbohydrate kinase
AK39_1874	COG2706	6-phosphogluconolactonase activity
AK39_1875	COG3813	Protein conserved in bacteria
AK39_1876	COG1357	PFAM Pentapeptide repeats (8 copies)
AK39_1877	COG0697	spore germination
AK39_1878	COG0789	Transcriptional regulator
AK39_1879	COG1253	flavin adenine dinucleotide binding
AK39_1885	COG0477	Major facilitator Superfamily
AK39_1887	COG2226	methyltransferase
AK39_1891	COG0628	permease
AK39_1892	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AK39_1893	COG0180	Tryptophanyl-tRNA synthetase
AK39_1895	COG1136	(ABC) transporter
AK39_1898	COG0110	maltose O-acetyltransferase activity
AK39_1899	COG0738	Major facilitator superfamily
AK39_190	COG3708	Transcriptional regulator
AK39_1900	COG1940	carbohydrate kinase activity
AK39_1901	COG0346	lactoylglutathione lyase activity
AK39_1908	COG1011	Hydrolase
AK39_1913	COG1131	(ABC) transporter
AK39_1915	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_1919	COG0778	Nitroreductase
AK39_1920	COG1733	regulation of RNA biosynthetic process
AK39_1923	COG0124	histidyl-tRNA synthetase
AK39_1924	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AK39_1925	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AK39_1926	COG3620	sequence-specific DNA binding
AK39_1929	COG2356	endonuclease I
AK39_193	COG1252	NADH dehydrogenase
AK39_1930	COG1288	antiporter activity
AK39_1931	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AK39_1934	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AK39_1935	COG1122	ATPase activity
AK39_1941	COG2249	NAD(P)H dehydrogenase (quinone) activity
AK39_1943	COG2031	fatty acid transporter
AK39_1945	COG1309	transcriptional regulator
AK39_1946	COG2076	Multidrug Resistance protein
AK39_1950	COG1131	(ABC) transporter
AK39_1951	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AK39_1954	COG2814	Major facilitator Superfamily
AK39_1955	COG1846	Transcriptional regulator
AK39_1957	COG0477	Major facilitator Superfamily
AK39_196	COG3584	3D domain protein
AK39_1968	COG2207	Transcriptional regulator
AK39_1968	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_1969	COG0662	Cupin 2, conserved barrel domain protein
AK39_1972	COG1595	DNA-templated transcription, initiation
AK39_1976	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AK39_1979	COG0531	amino acid
AK39_1980	COG1522	sequence-specific DNA binding
AK39_1981	COG1335	isochorismatase
AK39_1983	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AK39_1984	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AK39_1985	COG1760	l-serine dehydratase
AK39_1986	COG1760	l-serine dehydratase
AK39_1987	COG0814	amino acid
AK39_199	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AK39_1990	COG1309	transcriptional regulator
AK39_1991	COG2814	Major facilitator Superfamily
AK39_1992	COG2184	nucleotidyltransferase activity
AK39_1995	COG0534	Mate efflux family protein
AK39_2	COG0149	triose-phosphate isomerase activity
AK39_200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AK39_2002	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AK39_2006	COG0457	Tetratricopeptide repeat
AK39_2007	COG1609	Transcriptional regulator
AK39_2008	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AK39_2009	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AK39_2010	COG0561	phosphatase activity
AK39_2011	COG0673	inositol 2-dehydrogenase activity
AK39_2012	COG0738	Major facilitator superfamily
AK39_2016	COG1619	proteins homologs of microcin C7 resistance protein MccF
AK39_2018	COG0583	DNA-binding transcription factor activity
AK39_202	COG1268	BioY protein
AK39_2020	COG1139	Iron-sulfur cluster binding protein
AK39_2021	COG1556	Lactate utilization protein
AK39_2022	COG2271	Major facilitator Superfamily
AK39_2023	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_2024	COG2808	Putative FMN-binding domain
AK39_2025	COG0456	acetyltransferase
AK39_2026	COG1846	Transcriptional regulator
AK39_2027	COG2364	Membrane
AK39_2029	COG5002	protein histidine kinase activity
AK39_2029	COG3850	Histidine kinase
AK39_2032	COG0577	efflux transmembrane transporter activity
AK39_2033	COG1136	(ABC) transporter
AK39_2036	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AK39_2037	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK39_2039	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AK39_204	COG2050	protein possibly involved in aromatic compounds catabolism
AK39_2040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_2043	COG1476	TRANSCRIPTIONal
AK39_2049	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AK39_205	COG0423	glycine-tRNA ligase activity
AK39_2054	COG3850	Histidine kinase
AK39_2054	COG5002	protein histidine kinase activity
AK39_2055	COG0745	RESPONSE REGULATOR receiver
AK39_2060	COG2814	Major facilitator Superfamily
AK39_2072	COG0346	lactoylglutathione lyase activity
AK39_2075	COG1522	sequence-specific DNA binding
AK39_2078	COG0443	Heat shock 70 kDa protein
AK39_208	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AK39_2082	COG0640	Transcriptional regulator
AK39_2083	COG0346	lactoylglutathione lyase activity
AK39_2084	COG0798	PFAM Bile acid sodium symporter
AK39_209	COG5018	Exonuclease
AK39_2090	COG1121	(ABC) transporter
AK39_2091	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AK39_2092	COG0803	Belongs to the bacterial solute-binding protein 9 family
AK39_2093	COG2267	carboxylic ester hydrolase activity
AK39_2094	COG1575	Belongs to the MenA family. Type 1 subfamily
AK39_2096	COG5609	conserved protein (DUF2294)
AK39_2097	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AK39_2099	COG0288	reversible hydration of carbon dioxide
AK39_2100	COG0415	Belongs to the DNA photolyase family
AK39_2107	COG0598	Magnesium transport protein CorA
AK39_2108	COG0598	Magnesium transport protein CorA
AK39_2109	COG1846	Transcriptional regulator
AK39_2110	COG0583	DNA-binding transcription factor activity
AK39_2115	COG1335	isochorismatase
AK39_2116	COG2267	carboxylic ester hydrolase activity
AK39_2117	COG0753	catalase activity
AK39_2118	COG0737	Belongs to the 5'-nucleotidase family
AK39_2124	COG1115	amino acid carrier protein
AK39_2126	COG2066	Belongs to the glutaminase family
AK39_2127	COG4191	Histidine kinase
AK39_2128	COG4191	Histidine kinase
AK39_2129	COG0784	Response regulator, receiver
AK39_213	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AK39_2130	COG0697	spore germination
AK39_2131	COG0531	amino acid
AK39_2136	COG0281	malic enzyme
AK39_2138	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK39_2139	COG1114	Component of the transport system for branched-chain amino acids
AK39_2140	COG0531	amino acid
AK39_2141	COG0322	excinuclease ABC activity
AK39_2143	COG1396	sequence-specific DNA binding
AK39_2144	COG0252	asparaginase activity
AK39_2145	COG1027	Aspartate ammonia-lyase
AK39_2148	COG1063	alcohol dehydrogenase
AK39_215	COG2267	carboxylic ester hydrolase activity
AK39_2154	COG1113	amino acid transport
AK39_2157	COG1280	lysine exporter protein (LysE YggA)
AK39_2158	COG3403	YqcI/YcgG family
AK39_216	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AK39_2160	COG5577	PFAM Coat F domain
AK39_2163	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_2164	COG3848	Pyruvate phosphate dikinase
AK39_2164	COG0574	Belongs to the PEP-utilizing enzyme family
AK39_2167	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AK39_217	COG1522	sequence-specific DNA binding
AK39_2174	COG1960	acyl-CoA dehydrogenase activity
AK39_2176	COG0640	Transcriptional regulator
AK39_2177	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK39_218	COG0436	Aminotransferase
AK39_2180	COG1414	Transcriptional regulator
AK39_2181	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AK39_2182	COG1984	allophanate hydrolase subunit 2
AK39_2188	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AK39_219	COG1098	S1 RNA binding domain
AK39_2198	COG4335	DNA alkylation repair
AK39_220	COG2155	Conserved Protein
AK39_2200	COG0833	amino acid
AK39_2202	COG0730	response to heat
AK39_2208	COG0596	Alpha beta hydrolase
AK39_2209	COG0745	RESPONSE REGULATOR receiver
AK39_221	COG0166	Belongs to the GPI family
AK39_2210	COG0642	Histidine kinase
AK39_2214	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_2218	COG0456	acetyltransferase
AK39_2219	COG2207	Transcriptional regulator
AK39_222	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AK39_2224	COG1136	(ABC) transporter
AK39_2224	COG0577	efflux transmembrane transporter activity
AK39_2226	COG1725	Transcriptional regulator
AK39_2233	COG1846	Transcriptional regulator
AK39_2234	COG0778	Nitroreductase
AK39_2236	COG0714	Associated with various cellular activities
AK39_224	COG1285	pathogenesis
AK39_2242	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AK39_2244	COG0753	catalase activity
AK39_2245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AK39_2247	COG0463	Glycosyl transferase, family 2
AK39_2252	COG0463	Glycosyl transferase, family 2
AK39_2257	COG0714	Associated with various cellular activities
AK39_2261	COG0346	lactoylglutathione lyase activity
AK39_2262	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_2264	COG3279	Response regulator of the LytR AlgR family
AK39_2266	COG4377	Putative membrane peptidase family (DUF2324)
AK39_2269	COG3655	Transcriptional regulator
AK39_2271	COG1785	Belongs to the alkaline phosphatase family
AK39_2272	COG3239	Fatty acid desaturase
AK39_2273	COG1690	Belongs to the RtcB family
AK39_2274	COG0833	amino acid
AK39_2275	COG1414	Transcriptional regulator
AK39_2276	COG4187	Peptidase family M20/M25/M40
AK39_2277	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK39_2278	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AK39_2280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK39_2284	COG2329	Antibiotic biosynthesis monooxygenase
AK39_2291	COG1070	Carbohydrate kinase
AK39_2292	COG2390	Transcriptional regulator
AK39_2294	COG1172	Belongs to the binding-protein-dependent transport system permease family
AK39_2296	COG1879	ABC-type sugar transport system periplasmic component
AK39_2302	COG1595	DNA-templated transcription, initiation
AK39_2304	COG1388	LysM domain
AK39_2304	COG3584	3D domain protein
AK39_2312	COG1605	Chorismate mutase
AK39_2312	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AK39_2313	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AK39_2314	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AK39_2315	COG0287	Prephenate dehydrogenase
AK39_2318	COG1309	transcriptional regulator
AK39_2319	COG2409	Drug exporters of the RND superfamily
AK39_2319	COG1033	growth of symbiont in host cell
AK39_232	COG0544	peptidyl-prolyl cis-trans isomerase activity
AK39_2320	COG2409	Drug exporters of the RND superfamily
AK39_2320	COG1033	growth of symbiont in host cell
AK39_2322	COG0488	(ABC) transporter
AK39_2323	COG1368	sulfuric ester hydrolase activity
AK39_2324	COG0861	Integral membrane protein TerC family
AK39_2326	COG0726	polysaccharide deacetylase
AK39_2328	COG4912	Dna alkylation repair
AK39_2332	COG2318	DinB family
AK39_2333	COG0697	spore germination
AK39_2338	COG2746	aminoglycoside 3-N-acetyltransferase activity
AK39_2347	COG1116	anion transmembrane transporter activity
AK39_2348	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AK39_2349	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK39_2350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AK39_2352	COG0628	permease
AK39_2361	COG1131	(ABC) transporter
AK39_2366	COG5146	pantothenate kinase activity
AK39_2367	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AK39_2368	COG0436	Aminotransferase
AK39_2374	COG2226	methyltransferase
AK39_2377	COG2261	transglycosylase associated protein
AK39_2381	COG0477	Major facilitator Superfamily
AK39_2381	COG2814	Major facilitator Superfamily
AK39_2382	COG4533	DNA binding
AK39_2383	COG0789	Transcriptional regulator
AK39_2384	COG1664	Polymer-forming cytoskeletal
AK39_2386	COG2814	Major facilitator Superfamily
AK39_2390	COG1307	EDD domain protein, DegV family
AK39_2393	COG1164	Oligoendopeptidase f
AK39_2400	COG0745	RESPONSE REGULATOR receiver
AK39_2401	COG5002	protein histidine kinase activity
AK39_2402	COG2936	dipeptidyl-peptidase activity
AK39_2410	COG4948	Mandelate Racemase Muconate Lactonizing
AK39_2412	COG4166	transmembrane transport
AK39_2413	COG0519	Catalyzes the synthesis of GMP from XMP
AK39_2414	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AK39_2417	COG0586	Pfam SNARE associated Golgi protein
AK39_2424	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK39_2425	COG3938	Belongs to the proline racemase family
AK39_2427	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AK39_2428	COG1012	belongs to the aldehyde dehydrogenase family
AK39_2429	COG1115	amino acid carrier protein
AK39_2430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AK39_2432	COG3397	chitin binding
AK39_2437	COG4637	Psort location Cytoplasmic, score
AK39_2440	COG0514	ATP-dependent DNA helicase (RecQ)
AK39_2441	COG2105	PFAM AIG2 family protein
AK39_2444	COG3973	AAA domain
AK39_2455	COG0658	competence protein
AK39_2455	COG2333	competence protein COMEC
AK39_2460	COG2205	protein histidine kinase activity
AK39_2464	COG3397	chitin binding
AK39_2465	COG2153	protein acetylation
AK39_2466	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AK39_2469	COG0740	serine-type endopeptidase activity
AK39_2471	COG0517	IMP dehydrogenase activity
AK39_2471	COG4175	Glycine betaine
AK39_2472	COG4176	ABC-type proline glycine betaine transport system permease component
AK39_2478	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK39_2478	COG0456	acetyltransferase
AK39_2479	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_2481	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AK39_2482	COG0022	dehydrogenase e1 component
AK39_2483	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK39_2484	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AK39_2488	COG1959	2 iron, 2 sulfur cluster binding
AK39_2492	COG1349	DNA-binding transcription factor activity
AK39_2496	COG3284	Transcriptional regulator
AK39_2503	COG1309	transcriptional regulator
AK39_2504	COG3844	kynureninase activity
AK39_2505	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AK39_2506	COG3483	tryptophan 2,3-dioxygenase activity
AK39_2509	COG3773	Cell wall hydrolase
AK39_2509	COG3409	Peptidoglycan-binding domain 1 protein
AK39_251	COG0039	L-malate dehydrogenase activity
AK39_2510	COG2959	enzyme of heme biosynthesis
AK39_2513	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_2514	COG4129	membrane
AK39_2520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_2521	COG0697	spore germination
AK39_2523	COG0201	protein transport
AK39_2527	COG3227	Zinc metalloprotease (Elastase)
AK39_253	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AK39_2532	COG0076	glutamate decarboxylase activity
AK39_2537	COG1011	Hydrolase
AK39_254	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AK39_2542	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK39_255	COG0297	glycogen (starch) synthase activity
AK39_2550	COG0322	excinuclease ABC activity
AK39_2553	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AK39_2558	COG4667	esterase of the alpha-beta hydrolase superfamily
AK39_256	COG0058	SHG alpha-glucan phosphorylase activity
AK39_2564	COG3878	Protein conserved in bacteria
AK39_2571	COG1051	belongs to the nudix hydrolase family
AK39_2572	COG0592	DNA-directed DNA polymerase activity
AK39_2573	COG2816	NAD+ diphosphatase activity
AK39_2575	COG2223	nitrite transmembrane transporter activity
AK39_2582	COG0697	spore germination
AK39_2583	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_2584	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_2587	COG0584	glycerophosphoryl diester phosphodiesterase
AK39_2591	COG2814	Major facilitator Superfamily
AK39_2596	COG0693	protein deglycase activity
AK39_260	COG1278	Cold shock
AK39_2602	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK39_2605	COG0604	alcohol dehydrogenase
AK39_2608	COG2205	protein histidine kinase activity
AK39_261	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AK39_2611	COG1122	ATPase activity
AK39_2613	COG1794	racemase activity, acting on amino acids and derivatives
AK39_2614	COG1819	glycosyl
AK39_2616	COG5002	protein histidine kinase activity
AK39_2618	COG0561	phosphatase activity
AK39_262	COG1575	Belongs to the MenA family. Type 1 subfamily
AK39_2625	COG2124	cytochrome p450
AK39_263	COG1169	isochorismate synthase
AK39_264	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AK39_2640	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AK39_2642	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_2643	COG0460	homoserine dehydrogenase
AK39_2647	COG0577	efflux transmembrane transporter activity
AK39_2648	COG0577	efflux transmembrane transporter activity
AK39_2649	COG1136	(ABC) transporter
AK39_265	COG0596	Alpha beta hydrolase
AK39_2655	COG2205	protein histidine kinase activity
AK39_2657	COG0745	RESPONSE REGULATOR receiver
AK39_2659	COG3773	Cell wall hydrolase
AK39_266	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AK39_2662	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AK39_2663	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AK39_2666	COG1063	alcohol dehydrogenase
AK39_2668	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_2673	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AK39_2677	COG2814	Major facilitator Superfamily
AK39_268	COG4948	Mandelate Racemase Muconate Lactonizing
AK39_2683	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AK39_2683	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AK39_2688	COG3227	Zinc metalloprotease (Elastase)
AK39_2692	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AK39_2697	COG1686	Belongs to the peptidase S11 family
AK39_2698	COG2318	DinB family
AK39_2700	COG0572	uridine kinase
AK39_2701	COG1247	-acetyltransferase
AK39_2703	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AK39_2704	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AK39_2705	COG1024	Enoyl-CoA hydratase
AK39_2706	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AK39_2707	COG0511	ligase activity, forming carbon-carbon bonds
AK39_2708	COG0439	Biotin carboxylase
AK39_2709	COG1960	acyl-CoA dehydrogenase activity
AK39_2712	COG1309	transcriptional regulator
AK39_2714	COG1131	(ABC) transporter
AK39_2717	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK39_2718	COG1252	NADH dehydrogenase
AK39_2720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_2724	COG1309	transcriptional regulator
AK39_2729	COG1876	peptidase activity
AK39_2732	COG1476	TRANSCRIPTIONal
AK39_2733	COG0457	Tetratricopeptide repeat
AK39_2737	COG0737	Belongs to the 5'-nucleotidase family
AK39_274	COG3964	amidohydrolase
AK39_2741	COG3718	enzyme involved in inositol metabolism
AK39_2746	COG1012	belongs to the aldehyde dehydrogenase family
AK39_2748	COG0673	inositol 2-dehydrogenase activity
AK39_2749	COG2814	Major facilitator Superfamily
AK39_2750	COG1609	Transcriptional regulator
AK39_2751	COG0671	phosphoesterase, PA-phosphatase related
AK39_2752	COG2367	Beta-lactamase
AK39_2755	COG0768	penicillin binding
AK39_2757	COG1595	DNA-templated transcription, initiation
AK39_2761	COG2195	Cleaves the N-terminal amino acid of tripeptides
AK39_2769	COG1846	Transcriptional regulator
AK39_2770	COG3961	Belongs to the TPP enzyme family
AK39_2771	COG2226	methyltransferase
AK39_2773	COG3615	Tellurite resistance protein tehB
AK39_2773	COG0500	methyltransferase
AK39_2774	COG1136	(ABC) transporter
AK39_2774	COG0577	efflux transmembrane transporter activity
AK39_2778	COG1309	transcriptional regulator
AK39_2783	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_2786	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AK39_2787	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AK39_2788	COG2971	BadF BadG BcrA BcrD
AK39_2793	COG1649	PFAM Uncharacterised BCR, COG1649
AK39_2798	COG1595	DNA-templated transcription, initiation
AK39_2804	COG1396	sequence-specific DNA binding
AK39_2808	COG1132	(ABC) transporter
AK39_2809	COG1132	(ABC) transporter
AK39_281	COG0577	efflux transmembrane transporter activity
AK39_2812	COG2258	MOSC domain
AK39_2813	COG0583	DNA-binding transcription factor activity
AK39_2816	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AK39_2817	COG0583	DNA-binding transcription factor activity
AK39_282	COG0577	efflux transmembrane transporter activity
AK39_2825	COG0561	phosphatase activity
AK39_2826	COG0010	Belongs to the arginase family
AK39_2829	COG1278	Cold shock
AK39_283	COG1136	(ABC) transporter
AK39_2831	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_2839	COG1247	-acetyltransferase
AK39_284	COG0577	efflux transmembrane transporter activity
AK39_2846	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_285	COG0577	efflux transmembrane transporter activity
AK39_2855	COG2226	methyltransferase
AK39_2860	COG2814	Major facilitator Superfamily
AK39_2861	COG0596	Alpha beta hydrolase
AK39_2865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AK39_2866	COG1187	pseudouridine synthase activity
AK39_2867	COG2329	Antibiotic biosynthesis monooxygenase
AK39_287	COG0577	efflux transmembrane transporter activity
AK39_2870	COG1115	amino acid carrier protein
AK39_2872	COG2318	DinB family
AK39_2874	COG0776	regulation of translation
AK39_2877	COG2814	Major facilitator Superfamily
AK39_2878	COG3251	PFAM MbtH domain protein
AK39_2879	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AK39_288	COG2205	protein histidine kinase activity
AK39_2880	COG3433	isochorismatase activity
AK39_2880	COG1535	isochorismatase
AK39_2881	COG1021	2,3-dihydroxybenzoate-AMP ligase
AK39_2882	COG1169	isochorismate synthase
AK39_2883	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_2884	COG2223	nitrite transmembrane transporter activity
AK39_2888	COG0419	ATPase involved in DNA repair
AK39_2889	COG0420	3'-5' exonuclease activity
AK39_289	COG0745	RESPONSE REGULATOR receiver
AK39_2892	COG1024	Enoyl-CoA hydratase
AK39_2893	COG1280	lysine exporter protein (LysE YggA)
AK39_2894	COG1012	belongs to the aldehyde dehydrogenase family
AK39_2895	COG2084	Dehydrogenase
AK39_2896	COG1960	acyl-CoA dehydrogenase activity
AK39_2897	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AK39_2898	COG2079	MmgE PrpD family protein
AK39_2899	COG0372	Belongs to the citrate synthase family
AK39_29	COG1346	cytolysis
AK39_290	COG2207	Transcriptional regulator
AK39_290	COG3708	Transcriptional regulator
AK39_2900	COG4841	protein insertion into membrane
AK39_2901	COG2814	Major facilitator Superfamily
AK39_2902	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK39_2902	COG4499	WXG100 protein secretion system (Wss), protein YukC
AK39_291	COG1136	(ABC) transporter
AK39_2910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AK39_292	COG0577	efflux transmembrane transporter activity
AK39_2926	COG1715	Restriction endonuclease
AK39_2926	COG1787	Restriction endonuclease
AK39_2931	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK39_2932	COG0671	phosphoesterase, PA-phosphatase related
AK39_2933	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AK39_2934	COG4326	sporulation control protein
AK39_294	COG0586	Pfam SNARE associated Golgi protein
AK39_2942	COG1509	lysine 2,3-aminomutase activity
AK39_2943	COG3829	transcription factor binding
AK39_2944	COG0456	acetyltransferase
AK39_2945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AK39_2946	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AK39_2947	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AK39_2948	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AK39_2952	COG5506	Protein of unknown function (DUF1694)
AK39_2953	COG1012	belongs to the aldehyde dehydrogenase family
AK39_2954	COG1253	flavin adenine dinucleotide binding
AK39_2961	COG1174	glycine betaine transport
AK39_2962	COG0517	IMP dehydrogenase activity
AK39_2962	COG1125	glycine betaine transport
AK39_2969	COG1070	Carbohydrate kinase
AK39_2976	COG1064	alcohol dehydrogenase
AK39_2977	COG1737	Transcriptional regulator
AK39_2979	COG2197	response regulator
AK39_2980	COG4585	Histidine kinase
AK39_2980	COG2203	Gaf domain
AK39_2981	COG0668	transmembrane transport
AK39_2983	COG1051	belongs to the nudix hydrolase family
AK39_2984	COG1335	isochorismatase
AK39_2988	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK39_2989	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_2993	COG0367	asparagine synthase
AK39_2994	COG0071	Belongs to the small heat shock protein (HSP20) family
AK39_2995	COG1999	signal sequence binding
AK39_2996	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AK39_2997	COG1307	EDD domain protein, DegV family
AK39_2999	COG0805	protein transport
AK39_3	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AK39_30	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AK39_3001	COG1272	protein, Hemolysin III
AK39_3002	COG0204	Acyl-transferase
AK39_3003	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AK39_3004	COG0768	penicillin binding
AK39_3007	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK39_301	COG1597	lipid kinase activity
AK39_3011	COG0546	phosphoglycolate phosphatase activity
AK39_3013	COG4473	ABC transporter
AK39_3014	COG1131	(ABC) transporter
AK39_3016	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AK39_3018	COG0456	acetyltransferase
AK39_3020	COG1794	racemase activity, acting on amino acids and derivatives
AK39_3021	COG1454	alcohol dehydrogenase
AK39_3022	COG2610	gluconate transmembrane transporter activity
AK39_3028	COG0733	neurotransmitter:sodium symporter activity
AK39_3031	COG5002	protein histidine kinase activity
AK39_3031	COG3850	Histidine kinase
AK39_3032	COG0745	RESPONSE REGULATOR receiver
AK39_3033	COG0471	metal ion transport
AK39_3034	COG1929	Belongs to the glycerate kinase type-1 family
AK39_3053	COG1674	ftsk spoiiie
AK39_3057	COG0017	Asparaginyl-tRNA synthetase
AK39_3058	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AK39_3061	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AK39_3067	COG0018	arginyl-trna synthetase
AK39_3068	COG2521	methyltransferase
AK39_3068	COG2136	Putative SAM-dependent methyltransferase
AK39_307	COG0745	RESPONSE REGULATOR receiver
AK39_3071	COG1413	lyase activity
AK39_3072	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AK39_3075	COG0629	single-stranded DNA binding
AK39_3078	COG0488	(ABC) transporter
AK39_3079	COG1418	mRNA catabolic process
AK39_308	COG5002	protein histidine kinase activity
AK39_3082	COG5632	N-Acetylmuramoyl-L-alanine amidase
AK39_3085	COG2359	stage V sporulation protein S
AK39_3092	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AK39_3093	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AK39_3094	COG2146	nitrite reductase [NAD(P)H] activity
AK39_3095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AK39_3095	COG1587	Uroporphyrinogen-III synthase
AK39_3097	COG1648	precorrin-2 dehydrogenase activity
AK39_31	COG1647	Serine aminopeptidase, S33
AK39_3100	COG2223	nitrite transmembrane transporter activity
AK39_3102	COG0314	molybdopterin synthase activity
AK39_3103	COG0303	'Molybdopterin
AK39_3104	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK39_3105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AK39_3106	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AK39_3110	COG2181	nitrate reductase activity
AK39_3111	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AK39_3112	COG1140	nitrate reductase beta subunit
AK39_3113	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AK39_3116	COG0714	Associated with various cellular activities
AK39_3117	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AK39_3118	COG1305	Transglutaminase-like
AK39_3119	COG0386	Belongs to the glutathione peroxidase family
AK39_3124	COG1595	DNA-templated transcription, initiation
AK39_3125	COG0604	alcohol dehydrogenase
AK39_3127	COG0346	lactoylglutathione lyase activity
AK39_3128	COG1082	Xylose isomerase domain protein TIM barrel
AK39_3132	COG2226	methyltransferase
AK39_3137	COG3874	Sporulation protein YtfJ
AK39_3146	COG0456	acetyltransferase
AK39_315	COG1842	Phage shock protein A
AK39_3152	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_3153	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_3154	COG1819	glycosyl
AK39_3158	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AK39_3160	COG0561	phosphatase activity
AK39_3164	COG2211	Major facilitator Superfamily
AK39_3165	COG0154	amidase activity
AK39_3167	COG1876	peptidase activity
AK39_3169	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK39_3172	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK39_3173	COG1114	Component of the transport system for branched-chain amino acids
AK39_3176	COG1253	flavin adenine dinucleotide binding
AK39_3177	COG2839	Protein conserved in bacteria
AK39_3178	COG0702	epimerase
AK39_3181	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK39_3182	COG1607	acyl-coa hydrolase
AK39_3183	COG3689	TIGRFAM TIGR03943 family protein
AK39_3184	COG0701	Predicted permease
AK39_3186	COG2244	polysaccharide biosynthetic process
AK39_3187	COG0586	Pfam SNARE associated Golgi protein
AK39_3188	COG1051	belongs to the nudix hydrolase family
AK39_3189	COG5337	Spore coat protein CotH
AK39_3191	COG0406	alpha-ribazole phosphatase activity
AK39_3194	COG4166	transmembrane transport
AK39_3196	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AK39_3198	COG0702	epimerase
AK39_32	COG0557	exoribonuclease II activity
AK39_320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_3200	COG3443	Belongs to the bacterial solute-binding protein 9 family
AK39_3200	COG0803	Belongs to the bacterial solute-binding protein 9 family
AK39_3211	COG0456	acetyltransferase
AK39_3212	COG0523	cobalamin synthesis protein
AK39_3213	COG4989	oxidoreductase activity
AK39_3215	COG1231	oxidoreductase activity
AK39_3217	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AK39_3220	COG0783	Belongs to the Dps family
AK39_3221	COG3949	Membrane
AK39_3224	COG0840	transmembrane signaling receptor activity
AK39_3229	COG2814	Major facilitator Superfamily
AK39_3230	COG0667	Aldo Keto reductase
AK39_3231	COG0640	Transcriptional regulator
AK39_3232	COG1404	Belongs to the peptidase S8 family
AK39_3233	COG2002	toxin-antitoxin pair type II binding
AK39_3234	COG0577	efflux transmembrane transporter activity
AK39_3235	COG0577	efflux transmembrane transporter activity
AK39_324	COG1294	oxidase, subunit
AK39_3242	COG1752	Esterase of the alpha-beta hydrolase superfamily
AK39_3244	COG1279	arginine transmembrane transporter activity
AK39_3245	COG2814	Major facilitator Superfamily
AK39_3246	COG2814	Major facilitator Superfamily
AK39_3248	COG1082	Xylose isomerase domain protein TIM barrel
AK39_325	COG1271	oxidase subunit
AK39_3251	COG0318	PFAM AMP-dependent synthetase and ligase
AK39_3252	COG4264	IucA IucC family
AK39_3254	COG1247	-acetyltransferase
AK39_3255	COG1285	pathogenesis
AK39_3257	COG0726	polysaccharide deacetylase
AK39_3258	COG5002	protein histidine kinase activity
AK39_3259	COG0745	RESPONSE REGULATOR receiver
AK39_3261	COG1316	TRANSCRIPTIONal
AK39_3266	COG0460	homoserine dehydrogenase
AK39_327	COG0288	reversible hydration of carbon dioxide
AK39_3270	COG0726	polysaccharide deacetylase
AK39_3272	COG0300	oxidoreductase activity
AK39_3274	COG5002	protein histidine kinase activity
AK39_3275	COG0745	RESPONSE REGULATOR receiver
AK39_3276	COG1132	(ABC) transporter
AK39_3277	COG1132	(ABC) transporter
AK39_3279	COG0791	NLP P60 protein
AK39_3279	COG1388	LysM domain
AK39_3281	COG1686	Belongs to the peptidase S11 family
AK39_3285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AK39_3286	COG4988	ABC transporter
AK39_3287	COG1294	oxidase, subunit
AK39_3288	COG1271	oxidase subunit
AK39_3294	COG0583	DNA-binding transcription factor activity
AK39_3298	COG0411	ABC transporter
AK39_3300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK39_3301	COG2030	dehydratase
AK39_3302	COG0318	PFAM AMP-dependent synthetase and ligase
AK39_3305	COG0523	cobalamin synthesis protein
AK39_3306	COG1231	oxidoreductase activity
AK39_3307	COG0039	L-malate dehydrogenase activity
AK39_3308	COG0628	permease
AK39_3311	COG0778	Nitroreductase
AK39_3312	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AK39_3313	COG1959	2 iron, 2 sulfur cluster binding
AK39_3314	COG0583	DNA-binding transcription factor activity
AK39_3315	COG0697	spore germination
AK39_3317	COG4549	nuclear export factor GLE1
AK39_3318	COG1276	copper resistance
AK39_3318	COG2372	response to copper ion
AK39_332	COG0494	nUDIX hydrolase
AK39_3320	COG1114	Component of the transport system for branched-chain amino acids
AK39_3321	COG1114	Component of the transport system for branched-chain amino acids
AK39_3322	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AK39_3328	COG2132	Multicopper oxidase
AK39_3329	COG0006	proline dipeptidase activity
AK39_3333	COG4224	UPF0291 protein
AK39_3335	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AK39_3336	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK39_3338	COG2390	Transcriptional regulator
AK39_334	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AK39_3343	COG0531	amino acid
AK39_3344	COG0531	amino acid
AK39_3346	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AK39_3349	COG1914	H( )-stimulated, divalent metal cation uptake system
AK39_3353	COG0745	RESPONSE REGULATOR receiver
AK39_3354	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_3360	COG4166	transmembrane transport
AK39_3361	COG1073	alpha beta
AK39_3365	COG0427	acetyl-CoA hydrolase
AK39_3366	COG3279	Response regulator of the LytR AlgR family
AK39_3368	COG3384	dioxygenase
AK39_3369	COG2814	Major facilitator Superfamily
AK39_3374	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AK39_3376	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AK39_3377	COG0440	acetolactate synthase activity
AK39_3378	COG0028	Belongs to the TPP enzyme family
AK39_3379	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK39_338	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK39_3381	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AK39_3385	COG2084	Dehydrogenase
AK39_3388	COG2323	membrane
AK39_3389	COG5566	PFAM Mor transcription activator
AK39_339	COG1116	anion transmembrane transporter activity
AK39_3391	COG0733	neurotransmitter:sodium symporter activity
AK39_3392	COG2244	polysaccharide biosynthetic process
AK39_3395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AK39_3396	COG2223	nitrite transmembrane transporter activity
AK39_3397	COG4166	transmembrane transport
AK39_3399	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AK39_340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AK39_3401	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK39_3402	COG0477	Major facilitator Superfamily
AK39_3403	COG0477	Major facilitator Superfamily
AK39_3405	COG1966	Carbon starvation protein
AK39_3410	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK39_3411	COG1051	belongs to the nudix hydrolase family
AK39_3422	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AK39_3423	COG0784	Response regulator, receiver
AK39_3424	COG4191	Histidine kinase
AK39_3425	COG0281	malic enzyme
AK39_3426	COG1027	Aspartate ammonia-lyase
AK39_3428	COG0528	UMP kinase activity
AK39_3429	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK39_3432	COG1131	(ABC) transporter
AK39_3439	COG2733	membrane
AK39_344	COG1368	sulfuric ester hydrolase activity
AK39_3446	COG0785	Cytochrome C biogenesis protein
AK39_345	COG2267	carboxylic ester hydrolase activity
AK39_3450	COG3340	Belongs to the peptidase S51 family
AK39_3451	COG0534	Mate efflux family protein
AK39_3452	COG0534	Mate efflux family protein
AK39_3456	COG0114	fumarate hydratase activity
AK39_3457	COG1757	Na H antiporter
AK39_3458	COG1216	Glycosyl transferase, family 2
AK39_3458	COG0438	transferase activity, transferring glycosyl groups
AK39_346	COG4191	Histidine kinase
AK39_3460	COG0701	Predicted permease
AK39_3461	COG0523	cobalamin synthesis protein
AK39_3462	COG0697	spore germination
AK39_3463	COG1802	Transcriptional regulator
AK39_3469	COG0367	asparagine synthase
AK39_347	COG5002	protein histidine kinase activity
AK39_3476	COG0406	alpha-ribazole phosphatase activity
AK39_3478	COG1686	Belongs to the peptidase S11 family
AK39_348	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AK39_3483	COG1234	tRNA 3'-trailer cleavage
AK39_3484	COG1177	transmembrane transport
AK39_3485	COG0725	ABC transporter, periplasmic molybdate-binding protein
AK39_3486	COG3842	ATPase activity
AK39_3492	COG2329	Antibiotic biosynthesis monooxygenase
AK39_3496	COG1309	transcriptional regulator
AK39_3501	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AK39_3502	COG4786	Flagellar basal body rod
AK39_3505	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AK39_3506	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AK39_3508	COG1987	bacterial-type flagellum assembly
AK39_3509	COG1338	Plays a role in the flagellum-specific transport system
AK39_3511	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK39_3511	COG1776	CheC inhibitor of MCP methylation
AK39_3513	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK39_3514	COG0741	lytic transglycosylase activity
AK39_3515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AK39_3520	COG0457	Tetratricopeptide repeat
AK39_3520	COG0463	Glycosyl transferase, family 2
AK39_3526	COG0463	Glycosyl transferase, family 2
AK39_3528	COG0835	chemotaxis
AK39_3528	COG0784	Response regulator, receiver
AK39_3537	COG1157	protein secretion by the type III secretion system
AK39_3539	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK39_3541	COG1766	The M ring may be actively involved in energy transduction
AK39_3542	COG1677	Flagellar hook-basal body complex protein FliE
AK39_3543	COG1558	bacterial-type flagellum-dependent cell motility
AK39_3544	COG1815	bacterial-type flagellum-dependent cell motility
AK39_3549	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AK39_3550	COG1256	bacterial-type flagellum assembly
AK39_3554	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AK39_3557	COG1776	CheC inhibitor of MCP methylation
AK39_3557	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK39_3558	COG0643	Histidine kinase
AK39_3558	COG2198	Histidine kinase
AK39_3559	COG2198	Histidine kinase
AK39_3559	COG0643	Histidine kinase
AK39_3560	COG2201	protein-glutamate methylesterase activity
AK39_3561	COG1360	Flagellar Motor Protein
AK39_3562	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AK39_3564	COG1923	regulation of RNA biosynthetic process
AK39_3575	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AK39_3576	COG2323	membrane
AK39_358	COG0521	Mo-molybdopterin cofactor biosynthetic process
AK39_3580	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AK39_3581	COG0475	glutathione-regulated potassium exporter activity
AK39_3583	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AK39_3584	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK39_3585	COG3162	membrane
AK39_3588	COG1280	lysine exporter protein (LysE YggA)
AK39_3596	COG0328	RNA-DNA hybrid ribonuclease activity
AK39_360	COG0438	transferase activity, transferring glycosyl groups
AK39_3600	COG0454	-acetyltransferase
AK39_3606	COG1215	transferase activity, transferring glycosyl groups
AK39_3609	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AK39_361	COG0671	phosphoesterase, PA-phosphatase related
AK39_3615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AK39_3618	COG0754	glutathionylspermidine amidase activity
AK39_362	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AK39_3623	COG0456	acetyltransferase
AK39_3625	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AK39_3627	COG2311	Membrane
AK39_3628	COG2233	PERMEase
AK39_363	COG2267	carboxylic ester hydrolase activity
AK39_3630	COG0024	Methionine aminopeptidase
AK39_3631	COG3173	Aminoglycoside phosphotransferase
AK39_3633	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AK39_3634	COG1199	ATP-dependent helicase activity
AK39_3636	COG0116	Belongs to the methyltransferase superfamily
AK39_3638	COG4474	Belongs to the UPF0398 family
AK39_3647	COG4499	WXG100 protein secretion system (Wss), protein YukC
AK39_3647	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK39_3649	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AK39_3650	COG3935	DnaD domain protein
AK39_3654	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AK39_3654	COG1199	ATP-dependent helicase activity
AK39_3661	COG0438	transferase activity, transferring glycosyl groups
AK39_3662	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AK39_3665	COG1694	Mazg nucleotide pyrophosphohydrolase
AK39_3666	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_3668	COG2738	Putative neutral zinc metallopeptidase
AK39_367	COG1794	racemase activity, acting on amino acids and derivatives
AK39_3671	COG4347	Protein of unknown function (DUF1405)
AK39_3673	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AK39_3677	COG0457	Tetratricopeptide repeat
AK39_3678	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AK39_3681	COG0105	UTP biosynthetic process
AK39_3682	COG0142	geranyltranstransferase activity
AK39_3684	COG0142	geranyltranstransferase activity
AK39_3687	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AK39_369	COG1131	(ABC) transporter
AK39_370	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AK39_3701	COG0252	asparaginase activity
AK39_3702	COG0492	ferredoxin-NADP+ reductase activity
AK39_3706	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AK39_3707	COG4862	establishment of competence for transformation
AK39_3709	COG1408	metallophosphoesterase
AK39_371	COG1242	4 iron, 4 sulfur cluster binding
AK39_3711	COG1266	CAAX protease self-immunity
AK39_3712	COG0514	ATP-dependent DNA helicase (RecQ)
AK39_3713	COG4955	Helix-turn-helix domain
AK39_3714	COG1141	Ferredoxin
AK39_3715	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AK39_3718	COG2096	Adenosyltransferase
AK39_3719	COG5002	protein histidine kinase activity
AK39_3720	COG0745	RESPONSE REGULATOR receiver
AK39_3721	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AK39_3722	COG1333	cytochrome c biogenesis protein
AK39_3724	COG1187	pseudouridine synthase activity
AK39_3725	COG0700	Nucleoside recognition
AK39_3726	COG2715	membrane protein required for spore maturation
AK39_3727	COG1686	Belongs to the peptidase S11 family
AK39_3728	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AK39_3731	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AK39_3731	COG0392	lysyltransferase activity
AK39_3735	COG5002	protein histidine kinase activity
AK39_3736	COG0582	viral genome integration into host DNA
AK39_3738	COG1801	Protein of unknown function DUF72
AK39_3739	COG3852	Histidine kinase
AK39_3742	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK39_3743	COG1392	Phosphate transport regulator
AK39_3744	COG0306	phosphate transporter
AK39_3745	COG0730	response to heat
AK39_3748	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AK39_3748	COG1017	nitric oxide dioxygenase activity
AK39_375	COG1136	(ABC) transporter
AK39_3753	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AK39_3755	COG1114	Component of the transport system for branched-chain amino acids
AK39_3757	COG2197	response regulator
AK39_3758	COG4585	Histidine kinase
AK39_3759	COG4758	membrane
AK39_3762	COG1757	Na H antiporter
AK39_3766	COG0733	neurotransmitter:sodium symporter activity
AK39_3767	COG1648	precorrin-2 dehydrogenase activity
AK39_377	COG0582	viral genome integration into host DNA
AK39_3771	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AK39_3772	COG0529	Catalyzes the synthesis of activated sulfate
AK39_3776	COG0019	diaminopimelate decarboxylase activity
AK39_3778	COG1368	sulfuric ester hydrolase activity
AK39_3779	COG1183	phosphatidylcholine synthase activity
AK39_378	COG0490	domain, Protein
AK39_3782	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AK39_3789	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AK39_379	COG0475	glutathione-regulated potassium exporter activity
AK39_3794	COG0473	3-isopropylmalate dehydrogenase activity
AK39_3796	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AK39_3797	COG0440	acetolactate synthase activity
AK39_3798	COG0028	Belongs to the TPP enzyme family
AK39_3799	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK39_380	COG2814	Major facilitator Superfamily
AK39_3804	COG3874	Sporulation protein YtfJ
AK39_3805	COG4709	membrane
AK39_3806	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AK39_3807	COG1301	dicarboxylic acid transport
AK39_3809	COG1846	Transcriptional regulator
AK39_3812	COG1968	undecaprenyl-diphosphatase activity
AK39_3813	COG0534	Mate efflux family protein
AK39_3817	COG3173	Aminoglycoside phosphotransferase
AK39_3820	COG0716	FMN binding
AK39_3825	COG1696	Membrane protein involved in D-alanine export
AK39_3827	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AK39_3828	COG2070	2-Nitropropane dioxygenase
AK39_3829	COG1619	proteins homologs of microcin C7 resistance protein MccF
AK39_3831	COG1335	isochorismatase
AK39_3833	COG1522	sequence-specific DNA binding
AK39_3836	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AK39_3837	COG1131	(ABC) transporter
AK39_3839	COG1131	(ABC) transporter
AK39_3840	COG1725	Transcriptional regulator
AK39_3841	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AK39_3842	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AK39_3844	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AK39_3845	COG1780	Probably involved in ribonucleotide reductase function
AK39_3852	COG4873	Protein conserved in bacteria
AK39_3855	COG0720	synthase
AK39_3857	COG5002	protein histidine kinase activity
AK39_3859	COG2318	DinB family
AK39_3861	COG1846	Transcriptional regulator
AK39_3862	COG3852	Histidine kinase
AK39_3864	COG2861	carbohydrate metabolic process
AK39_3867	COG0235	Class ii aldolase
AK39_3872	COG1349	DNA-binding transcription factor activity
AK39_3875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AK39_3878	COG3842	ATPase activity
AK39_3879	COG3842	ATPase activity
AK39_388	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AK39_3881	COG1840	ABC-type Fe3 transport system, periplasmic component
AK39_3884	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AK39_3886	COG3243	poly(R)-hydroxyalkanoic acid synthase
AK39_3887	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_3891	COG2030	dehydratase
AK39_3893	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AK39_3894	COG0861	Integral membrane protein TerC family
AK39_3895	COG2116	formate transmembrane transporter activity
AK39_3897	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AK39_390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK39_3901	COG2186	Transcriptional regulator
AK39_3902	COG5002	protein histidine kinase activity
AK39_3903	COG0745	RESPONSE REGULATOR receiver
AK39_3905	COG3835	regulator
AK39_3906	COG0277	FAD linked oxidase domain protein
AK39_3907	COG0247	lactate metabolic process
AK39_3908	COG2340	Cysteine-rich secretory protein family
AK39_3910	COG0564	pseudouridine synthase activity
AK39_3912	COG2409	Drug exporters of the RND superfamily
AK39_3914	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AK39_3915	COG1177	transmembrane transport
AK39_3916	COG1176	ABC-type spermidine putrescine transport system, permease component I
AK39_3917	COG3842	ATPase activity
AK39_3918	COG1012	belongs to the aldehyde dehydrogenase family
AK39_3924	COG0681	Belongs to the peptidase S26 family
AK39_3925	COG1686	Belongs to the peptidase S11 family
AK39_3927	COG2226	methyltransferase
AK39_3938	COG1476	TRANSCRIPTIONal
AK39_394	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AK39_3940	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK39_395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK39_3950	COG5634	Uncharacterized conserved protein (DUF2278)
AK39_3951	COG1620	l-lactate permease
AK39_3958	COG0512	Glutamine amidotransferase of anthranilate synthase
AK39_3958	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AK39_3960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK39_3961	COG5492	domain, Protein
AK39_3964	COG2382	esterase
AK39_3965	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AK39_3966	COG2153	protein acetylation
AK39_397	COG0303	'Molybdopterin
AK39_3974	COG1091	dTDP-4-dehydrorhamnose reductase activity
AK39_3977	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AK39_398	COG1763	Mo-molybdopterin cofactor biosynthetic process
AK39_3981	COG0463	Glycosyl transferase, family 2
AK39_3981	COG0457	Tetratricopeptide repeat
AK39_3985	COG1216	Glycosyl transferase, family 2
AK39_3986	COG0772	Belongs to the SEDS family
AK39_3987	COG0772	Belongs to the SEDS family
AK39_399	COG0314	molybdopterin synthase activity
AK39_3991	COG0564	pseudouridine synthase activity
AK39_3992	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AK39_3993	COG2357	RelA SpoT domain protein
AK39_3995	COG4116	CYTH
AK39_3996	COG2346	COG2346, Truncated hemoglobins
AK39_3999	COG1164	Oligoendopeptidase f
AK39_4001	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK39_4002	COG4862	establishment of competence for transformation
AK39_4003	COG0861	Integral membrane protein TerC family
AK39_4004	COG1393	Belongs to the ArsC family
AK39_4006	COG4166	transmembrane transport
AK39_4007	COG0534	Mate efflux family protein
AK39_4008	COG4608	Belongs to the ABC transporter superfamily
AK39_4009	COG0444	Belongs to the ABC transporter superfamily
AK39_4010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK39_4011	COG0601	transmembrane transport
AK39_4012	COG4166	transmembrane transport
AK39_4014	COG0180	Tryptophanyl-tRNA synthetase
AK39_4016	COG5504	Zn-dependent protease
AK39_4017	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AK39_4018	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK39_402	COG4975	Glucose uptake
AK39_4021	COG2267	carboxylic ester hydrolase activity
AK39_4023	COG0542	response to heat
AK39_4025	COG0561	phosphatase activity
AK39_4028	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_4030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AK39_4032	COG2996	Protein conserved in bacteria
AK39_4036	COG0004	ammonium transporteR
AK39_4037	COG0753	catalase activity
AK39_4039	COG0367	asparagine synthase
AK39_404	COG1329	Transcriptional regulator
AK39_4044	COG0179	Fumarylacetoacetate (FAA) hydrolase
AK39_4052	COG1074	ATP-dependent DNA helicase activity
AK39_4053	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AK39_4055	COG0398	Pfam SNARE associated Golgi protein
AK39_4056	COG4903	ComK protein
AK39_4059	COG1278	Cold shock
AK39_4061	COG2224	Isocitrate lyase
AK39_4062	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AK39_4063	COG0497	DNA recombination
AK39_4066	COG0697	spore germination
AK39_4067	COG0840	transmembrane signaling receptor activity
AK39_4068	COG0501	Belongs to the peptidase M48B family
AK39_4073	COG0745	RESPONSE REGULATOR receiver
AK39_4074	COG2205	protein histidine kinase activity
AK39_4077	COG3708	Transcriptional regulator
AK39_4077	COG2207	Transcriptional regulator
AK39_4078	COG1595	DNA-templated transcription, initiation
AK39_408	COG3832	glyoxalase III activity
AK39_4080	COG1078	dGTPase activity
AK39_4081	COG1408	metallophosphoesterase
AK39_4088	COG3209	COG3209 Rhs family protein
AK39_4094	COG0318	PFAM AMP-dependent synthetase and ligase
AK39_4096	COG0095	Lipoate-protein ligase
AK39_4097	COG1234	tRNA 3'-trailer cleavage
AK39_4099	COG1609	Transcriptional regulator
AK39_41	COG3223	Belongs to the PsiE family
AK39_410	COG2814	Major facilitator Superfamily
AK39_4104	COG1511	domain protein
AK39_4105	COG1309	transcriptional regulator
AK39_411	COG2081	HI0933 family
AK39_4114	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AK39_4115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK39_4116	COG2329	Antibiotic biosynthesis monooxygenase
AK39_4117	COG3428	Bacterial PH domain
AK39_4118	COG3402	PFAM membrane-flanked domain
AK39_412	COG2244	polysaccharide biosynthetic process
AK39_4127	COG3428	Bacterial PH domain
AK39_4129	COG3402	PFAM membrane-flanked domain
AK39_413	COG1187	pseudouridine synthase activity
AK39_4131	COG1309	transcriptional regulator
AK39_4134	COG4473	ABC transporter
AK39_4135	COG1131	(ABC) transporter
AK39_4136	COG0537	adenosine 5'-monophosphoramidase activity
AK39_4137	COG4980	gas vesicle protein
AK39_414	COG1349	DNA-binding transcription factor activity
AK39_4141	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AK39_4142	COG3973	AAA domain
AK39_4144	COG0477	Major facilitator Superfamily
AK39_4145	COG0477	Major facilitator Superfamily
AK39_415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AK39_4153	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AK39_4155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AK39_4156	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AK39_416	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AK39_4160	COG2267	carboxylic ester hydrolase activity
AK39_4162	COG0457	Tetratricopeptide repeat
AK39_4163	COG0346	lactoylglutathione lyase activity
AK39_4164	COG0346	lactoylglutathione lyase activity
AK39_4165	COG2814	Major facilitator Superfamily
AK39_4166	COG1309	transcriptional regulator
AK39_4170	COG4717	serine-type aminopeptidase activity
AK39_4171	COG0420	3'-5' exonuclease activity
AK39_4177	COG0393	Putative heavy-metal-binding
AK39_418	COG1523	belongs to the glycosyl hydrolase 13 family
AK39_4182	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK39_4182	COG2198	Histidine kinase
AK39_4182	COG2205	protein histidine kinase activity
AK39_4182	COG0784	Response regulator, receiver
AK39_4183	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AK39_4184	COG2208	phosphoserine phosphatase activity
AK39_4186	COG1191	sigma factor activity
AK39_419	COG0510	thiamine kinase activity
AK39_4191	COG3237	CsbD-like
AK39_42	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_4201	COG2770	Histidine kinase
AK39_4201	COG3437	response regulator, receiver
AK39_4206	COG1959	2 iron, 2 sulfur cluster binding
AK39_4207	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AK39_4208	COG2376	Dihydroxyacetone kinase
AK39_4210	COG2376	Dihydroxyacetone kinase
AK39_4214	COG1183	phosphatidylcholine synthase activity
AK39_4219	COG3320	Male sterility
AK39_4219	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AK39_422	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_4229	COG0477	Major facilitator Superfamily
AK39_4237	COG0305	Participates in initiation and elongation during chromosome replication
AK39_424	COG1363	Peptidase, m42
AK39_4240	COG4978	Transcriptional regulator
AK39_4240	COG0789	Transcriptional regulator
AK39_4245	COG3181	Tripartite tricarboxylate transporter family receptor
AK39_4246	COG4565	transcriptional regulatory protein
AK39_4247	COG3290	protein histidine kinase activity
AK39_4248	COG0477	Major facilitator Superfamily
AK39_425	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AK39_4254	COG4608	Belongs to the ABC transporter superfamily
AK39_4255	COG0444	Belongs to the ABC transporter superfamily
AK39_4256	COG0444	Belongs to the ABC transporter superfamily
AK39_4257	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK39_4258	COG0601	transmembrane transport
AK39_426	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK39_4265	COG3938	Belongs to the proline racemase family
AK39_427	COG4848	Belongs to the UPF0354 family
AK39_4270	COG1363	Peptidase, m42
AK39_4273	COG1024	Enoyl-CoA hydratase
AK39_4276	COG1696	Membrane protein involved in D-alanine export
AK39_4279	COG4196	transglutaminase domain protein
AK39_428	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK39_4280	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK39_4282	COG2244	polysaccharide biosynthetic process
AK39_4283	COG0653	protein targeting
AK39_4287	COG0659	secondary active sulfate transmembrane transporter activity
AK39_4290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AK39_4292	COG5632	N-Acetylmuramoyl-L-alanine amidase
AK39_4292	COG3409	Peptidoglycan-binding domain 1 protein
AK39_4294	COG0561	phosphatase activity
AK39_4297	COG3527	Alpha-acetolactate decarboxylase
AK39_4298	COG0028	Belongs to the TPP enzyme family
AK39_430	COG1674	ftsk spoiiie
AK39_4304	COG0189	ligase activity
AK39_4307	COG1126	abc transporter atp-binding protein
AK39_4308	COG0765	amino acid transport
AK39_4309	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK39_4310	COG1132	(ABC) transporter
AK39_4311	COG1132	(ABC) transporter
AK39_4312	COG1132	(ABC) transporter
AK39_4313	COG1012	belongs to the aldehyde dehydrogenase family
AK39_4315	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AK39_4316	COG0531	amino acid
AK39_4318	COG0693	protein deglycase activity
AK39_4318	COG0753	catalase activity
AK39_4319	COG0693	protein deglycase activity
AK39_4321	COG2211	Major facilitator Superfamily
AK39_4322	COG4533	DNA binding
AK39_4323	COG2249	NAD(P)H dehydrogenase (quinone) activity
AK39_4325	COG1733	regulation of RNA biosynthetic process
AK39_4326	COG2814	Major facilitator Superfamily
AK39_4327	COG1309	transcriptional regulator
AK39_4328	COG2076	Multidrug Resistance protein
AK39_4329	COG2076	Multidrug Resistance protein
AK39_433	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_4331	COG1522	sequence-specific DNA binding
AK39_4332	COG0697	spore germination
AK39_4335	COG2259	Doxx family
AK39_4337	COG1263	PTS System
AK39_4337	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK39_4339	COG1737	Transcriptional regulator
AK39_4341	COG0475	glutathione-regulated potassium exporter activity
AK39_4342	COG0531	amino acid
AK39_4348	COG0586	Pfam SNARE associated Golgi protein
AK39_4355	COG3546	catalase activity
AK39_4356	COG1114	Component of the transport system for branched-chain amino acids
AK39_4359	COG5522	Integral membrane protein (intg_mem_TP0381)
AK39_4361	COG1136	(ABC) transporter
AK39_4362	COG0577	efflux transmembrane transporter activity
AK39_4363	COG1388	LysM domain
AK39_4363	COG3584	3D domain protein
AK39_4367	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AK39_4368	COG1447	Phosphotransferase system cellobiose-specific component IIA
AK39_4369	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AK39_4369	COG3711	transcriptional antiterminator
AK39_437	COG2309	aminopeptidase activity
AK39_4372	COG1283	sodium-dependent phosphate transmembrane transporter activity
AK39_4373	COG0604	alcohol dehydrogenase
AK39_4374	COG1316	TRANSCRIPTIONal
AK39_4376	COG0730	response to heat
AK39_4377	COG2210	Belongs to the sulfur carrier protein TusA family
AK39_4379	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK39_4381	COG0425	Belongs to the sulfur carrier protein TusA family
AK39_4382	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK39_4382	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_4383	COG0425	Belongs to the sulfur carrier protein TusA family
AK39_4383	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK39_4384	COG1937	Protein conserved in bacteria
AK39_4385	COG0446	pyridine nucleotide-disulphide oxidoreductase
AK39_439	COG3118	belongs to the thioredoxin family
AK39_4390	COG2719	SpoVR family
AK39_4391	COG0778	Nitroreductase
AK39_4399	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AK39_440	COG4851	CamS sex pheromone cAM373 precursor
AK39_4400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK39_4402	COG1609	Transcriptional regulator
AK39_4403	COG1263	PTS System
AK39_4403	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK39_4404	COG1621	beta-fructofuranosidase activity
AK39_4405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AK39_4409	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_441	COG1609	Transcriptional regulator
AK39_4410	COG2252	PERMEase
AK39_4413	COG1846	Transcriptional regulator
AK39_4414	COG2814	Major facilitator Superfamily
AK39_4415	COG2205	protein histidine kinase activity
AK39_4422	COG0351	phosphomethylpyrimidine kinase
AK39_4423	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK39_4425	COG2104	thiamine diphosphate biosynthetic process
AK39_4426	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK39_4427	COG0352	thiamine-phosphate diphosphorylase activity
AK39_4428	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AK39_4429	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK39_4430	COG1116	anion transmembrane transporter activity
AK39_4431	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AK39_4435	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AK39_4460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AK39_4462	COG0581	inorganic phosphate transmembrane transporter activity
AK39_4463	COG0573	inorganic phosphate transmembrane transporter activity
AK39_4464	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AK39_4465	COG1918	ferrous iron import across plasma membrane
AK39_4465	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AK39_4466	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AK39_4467	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AK39_4469	COG0531	amino acid
AK39_4470	COG0697	spore germination
AK39_4471	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK39_4474	COG4990	cell redox homeostasis
AK39_4475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AK39_4476	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AK39_4479	COG0475	glutathione-regulated potassium exporter activity
AK39_4479	COG0569	domain protein
AK39_448	COG0666	response to abiotic stimulus
AK39_4484	COG2252	PERMEase
AK39_4485	COG1113	amino acid transport
AK39_4488	COG1114	Component of the transport system for branched-chain amino acids
AK39_4489	COG3104	oligopeptide transport
AK39_4492	COG1476	TRANSCRIPTIONal
AK39_4493	COG1388	LysM domain
AK39_4493	COG3584	3D domain protein
AK39_4494	COG0840	transmembrane signaling receptor activity
AK39_4495	COG1968	undecaprenyl-diphosphatase activity
AK39_45	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AK39_450	COG0745	RESPONSE REGULATOR receiver
AK39_4500	COG3568	Endonuclease Exonuclease Phosphatase
AK39_4503	COG1063	alcohol dehydrogenase
AK39_4507	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AK39_4508	COG1879	ABC-type sugar transport system periplasmic component
AK39_4509	COG1172	Belongs to the binding-protein-dependent transport system permease family
AK39_4510	COG1129	ABC transporter
AK39_4512	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AK39_4513	COG1609	Transcriptional regulator
AK39_4514	COG0477	Major facilitator Superfamily
AK39_4515	COG0477	Major facilitator Superfamily
AK39_4516	COG1846	Transcriptional regulator
AK39_4517	COG2271	Major facilitator Superfamily
AK39_4519	COG4608	Belongs to the ABC transporter superfamily
AK39_452	COG0123	including yeast histone deacetylase and acetoin utilization protein
AK39_4520	COG0601	transmembrane transport
AK39_4522	COG0747	negative chemotaxis
AK39_4525	COG0659	secondary active sulfate transmembrane transporter activity
AK39_4528	COG5002	protein histidine kinase activity
AK39_4529	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AK39_453	COG0517	IMP dehydrogenase activity
AK39_4530	COG2378	regulation of single-species biofilm formation
AK39_4535	COG0833	amino acid
AK39_4536	COG0765	amino acid transport
AK39_4537	COG0765	amino acid transport
AK39_4538	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK39_4539	COG1126	abc transporter atp-binding protein
AK39_454	COG0454	-acetyltransferase
AK39_4540	COG1115	amino acid carrier protein
AK39_4541	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AK39_4543	COG0697	spore germination
AK39_4546	COG0366	Alpha amylase catalytic
AK39_4547	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK39_4547	COG1263	PTS System
AK39_4548	COG2188	Transcriptional regulator
AK39_4549	COG0531	amino acid
AK39_455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AK39_4553	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK39_4554	COG0714	Associated with various cellular activities
AK39_4555	COG4548	von Willebrand factor, type A
AK39_4557	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AK39_4558	COG0156	8-amino-7-oxononanoate synthase activity
AK39_4559	COG2226	methyltransferase
AK39_4561	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_4562	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_4563	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_4564	COG3104	oligopeptide transport
AK39_4567	COG1620	l-lactate permease
AK39_4568	COG1027	Aspartate ammonia-lyase
AK39_4569	COG1253	flavin adenine dinucleotide binding
AK39_457	COG1595	DNA-templated transcription, initiation
AK39_4570	COG0346	lactoylglutathione lyase activity
AK39_4571	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK39_4572	COG1316	TRANSCRIPTIONal
AK39_4573	COG2720	vancomycin resistance protein
AK39_4577	COG3227	Zinc metalloprotease (Elastase)
AK39_4581	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AK39_4582	COG2217	Heavy metal translocating P-type atpase
AK39_4583	COG0640	Transcriptional regulator
AK39_4584	COG0531	amino acid
AK39_4589	COG3383	formate dehydrogenase (NAD+) activity
AK39_459	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AK39_4590	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AK39_4591	COG0456	acetyltransferase
AK39_4591	COG0454	-acetyltransferase
AK39_4593	COG0745	RESPONSE REGULATOR receiver
AK39_4594	COG5002	protein histidine kinase activity
AK39_4596	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_4599	COG0281	malic enzyme
AK39_46	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AK39_4600	COG3493	citrate carrier protein
AK39_4601	COG4565	transcriptional regulatory protein
AK39_4602	COG3290	protein histidine kinase activity
AK39_4604	COG4990	cell redox homeostasis
AK39_4606	COG5002	protein histidine kinase activity
AK39_4607	COG0745	RESPONSE REGULATOR receiver
AK39_4608	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AK39_4610	COG0395	ABC-type sugar transport system, permease component
AK39_4611	COG1175	transmembrane transport
AK39_4612	COG3842	ATPase activity
AK39_4613	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AK39_4617	COG2851	Citrate transporter
AK39_4620	COG3290	protein histidine kinase activity
AK39_4622	COG2268	Band 7 protein
AK39_4623	COG1585	Membrane protein implicated in regulation of membrane protease activity
AK39_4625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AK39_4629	COG2766	serine protein kinase
AK39_463	COG0626	cystathionine gamma-synthase activity
AK39_4632	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AK39_4634	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AK39_4636	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AK39_4637	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AK39_464	COG1956	GAF domain-containing protein
AK39_465	COG1309	transcriptional regulator
AK39_466	COG1309	transcriptional regulator
AK39_4662	COG0735	belongs to the Fur family
AK39_4663	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AK39_4667	COG4555	ABC transporter
AK39_4669	COG0070	glutamate synthase
AK39_4669	COG0069	glutamate synthase activity
AK39_4669	COG0067	glutamate synthase
AK39_467	COG0697	spore germination
AK39_4670	COG4129	membrane
AK39_4671	COG1132	(ABC) transporter
AK39_4676	COG1194	a g-specific adenine glycosylase
AK39_4677	COG1988	membrane-bound metal-dependent
AK39_468	COG0583	DNA-binding transcription factor activity
AK39_4683	COG1090	epimerase
AK39_4684	COG1228	amidohydrolase
AK39_4688	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AK39_4691	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AK39_4691	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AK39_4694	COG0463	Glycosyl transferase, family 2
AK39_4697	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK39_4698	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK39_4698	COG1263	PTS System
AK39_4699	COG2066	Belongs to the glutaminase family
AK39_470	COG1104	cysteine desulfurase activity
AK39_4704	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AK39_4705	COG0833	amino acid
AK39_4707	COG3829	transcription factor binding
AK39_4709	COG0101	tRNA pseudouridine synthase activity
AK39_4756	COG1484	DNA-dependent DNA replication
AK39_476	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AK39_4763	COG1396	sequence-specific DNA binding
AK39_4767	COG0582	viral genome integration into host DNA
AK39_4768	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AK39_4769	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AK39_477	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AK39_4774	COG0535	radical SAM domain protein
AK39_4776	COG0387	Pfam Sodium calcium exchanger
AK39_4777	COG3871	stress protein (general stress protein 26)
AK39_4780	COG0586	Pfam SNARE associated Golgi protein
AK39_4783	COG0681	Belongs to the peptidase S26 family
AK39_4785	COG0697	spore germination
AK39_4786	COG2217	Heavy metal translocating P-type atpase
AK39_4787	COG1295	ribonuclease BN
AK39_4789	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AK39_479	COG3874	Sporulation protein YtfJ
AK39_4792	COG3853	Toxic anion resistance protein (TelA)
AK39_4794	COG0861	Integral membrane protein TerC family
AK39_4795	COG2310	stress, protein
AK39_4796	COG2310	stress, protein
AK39_4797	COG2310	stress, protein
AK39_48	COG0840	transmembrane signaling receptor activity
AK39_48	COG3290	protein histidine kinase activity
AK39_480	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AK39_4800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AK39_4803	COG2270	Major facilitator Superfamily
AK39_481	COG0827	DNA restriction-modification system
AK39_4812	COG0488	(ABC) transporter
AK39_4813	COG1116	anion transmembrane transporter activity
AK39_4815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK39_4818	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AK39_482	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AK39_4824	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK39_4824	COG1263	PTS System
AK39_4824	COG2190	(PTS) system
AK39_4825	COG0366	Alpha amylase catalytic
AK39_4826	COG0840	transmembrane signaling receptor activity
AK39_4827	COG0840	transmembrane signaling receptor activity
AK39_4829	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK39_4830	COG0765	amino acid transport
AK39_4832	COG0723	plastoquinol--plastocyanin reductase activity
AK39_4832	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK39_4833	COG2814	Major facilitator Superfamily
AK39_4834	COG3541	Predicted nucleotidyltransferase
AK39_4838	COG5002	protein histidine kinase activity
AK39_4844	COG0166	Belongs to the GPI family
AK39_4847	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_4848	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_4849	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_4850	COG0235	Class ii aldolase
AK39_4852	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AK39_4853	COG0450	alkyl hydroperoxide reductase
AK39_4856	COG1473	amidohydrolase
AK39_486	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_4862	COG4807	Protein conserved in bacteria
AK39_4864	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AK39_4865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AK39_4866	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK39_4869	COG2309	aminopeptidase activity
AK39_4870	COG2076	Multidrug Resistance protein
AK39_4871	COG1012	belongs to the aldehyde dehydrogenase family
AK39_4873	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AK39_4874	COG0546	phosphoglycolate phosphatase activity
AK39_4875	COG1597	lipid kinase activity
AK39_4880	COG1846	Transcriptional regulator
AK39_4881	COG0003	Pfam Anion-transporting ATPase
AK39_4882	COG0003	Pfam Anion-transporting ATPase
AK39_4885	COG1464	Belongs to the NlpA lipoprotein family
AK39_4886	COG2011	ABC-type metal ion transport system permease component
AK39_4887	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AK39_4888	COG1335	isochorismatase
AK39_4892	COG4851	CamS sex pheromone cAM373 precursor
AK39_4894	COG0210	DNA helicase
AK39_4899	COG0151	Belongs to the GarS family
AK39_4901	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AK39_4903	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AK39_4906	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AK39_4908	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AK39_4909	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AK39_4910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AK39_4915	COG0745	RESPONSE REGULATOR receiver
AK39_4916	COG2205	protein histidine kinase activity
AK39_4919	COG1968	undecaprenyl-diphosphatase activity
AK39_4923	COG1215	transferase activity, transferring glycosyl groups
AK39_4929	COG2226	methyltransferase
AK39_4936	COG5002	protein histidine kinase activity
AK39_4938	COG2252	PERMEase
AK39_4942	COG1266	CAAX protease self-immunity
AK39_4945	COG0488	(ABC) transporter
AK39_4946	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AK39_4947	COG0456	acetyltransferase
AK39_4948	COG1214	PFAM Peptidase M22, glycoprotease
AK39_4949	COG0802	atpase or kinase
AK39_495	COG0589	response to stress
AK39_496	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_4968	COG2183	response to ionizing radiation
AK39_4969	COG2337	Toxic component of a toxin-antitoxin (TA) module
AK39_4970	COG0864	Transcriptional regulator
AK39_4971	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AK39_4972	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AK39_4974	COG4294	response to UV
AK39_4975	COG0457	Tetratricopeptide repeat
AK39_4975	COG0705	Rhomboid family
AK39_4977	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AK39_4980	COG2814	Major facilitator Superfamily
AK39_4982	COG0179	Fumarylacetoacetate (FAA) hydrolase
AK39_4983	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AK39_4986	COG0561	phosphatase activity
AK39_4987	COG4608	Belongs to the ABC transporter superfamily
AK39_4988	COG0561	phosphatase activity
AK39_4989	COG0444	Belongs to the ABC transporter superfamily
AK39_499	COG1476	TRANSCRIPTIONal
AK39_4991	COG0601	transmembrane transport
AK39_4992	COG0747	negative chemotaxis
AK39_4995	COG0488	(ABC) transporter
AK39_4999	COG5298	Protein conserved in bacteria
AK39_5	COG4974	Belongs to the 'phage' integrase family
AK39_50	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AK39_5000	COG0084	hydrolase, TatD family'
AK39_5003	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_5005	COG1609	Transcriptional regulator
AK39_5007	COG0204	Acyl-transferase
AK39_501	COG0662	Cupin 2, conserved barrel domain protein
AK39_5010	COG0697	spore germination
AK39_5011	COG0583	DNA-binding transcription factor activity
AK39_5014	COG1910	domain protein
AK39_5015	COG0725	ABC transporter, periplasmic molybdate-binding protein
AK39_5016	COG0725	ABC transporter, periplasmic molybdate-binding protein
AK39_5017	COG4149	molybdate abc transporter
AK39_502	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_5020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK39_5021	COG0656	L-ascorbic acid biosynthetic process
AK39_5022	COG4166	transmembrane transport
AK39_5023	COG4166	transmembrane transport
AK39_5026	COG2207	Transcriptional regulator
AK39_5028	COG4166	transmembrane transport
AK39_5029	COG4608	Belongs to the ABC transporter superfamily
AK39_5030	COG0444	Belongs to the ABC transporter superfamily
AK39_5031	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK39_5032	COG0601	transmembrane transport
AK39_5035	COG2814	Major facilitator Superfamily
AK39_5037	COG2271	Major facilitator Superfamily
AK39_5038	COG0277	FAD linked oxidase domain protein
AK39_5041	COG1464	Belongs to the NlpA lipoprotein family
AK39_5042	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AK39_5043	COG2011	ABC-type metal ion transport system permease component
AK39_5044	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_5052	COG0823	Involved in the tonB-independent uptake of proteins
AK39_5052	COG1506	peptidase
AK39_5052	COG4946	Tricorn protease homolog
AK39_5053	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AK39_5058	COG0596	Alpha beta hydrolase
AK39_5059	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AK39_5061	COG4856	YbbR-like protein
AK39_5062	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AK39_5080	COG0726	polysaccharide deacetylase
AK39_5081	COG2194	sulfuric ester hydrolase activity
AK39_5083	COG0489	protein tyrosine kinase activity
AK39_5084	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK39_5088	COG0101	tRNA pseudouridine synthase activity
AK39_5089	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AK39_509	COG0006	proline dipeptidase activity
AK39_5090	COG1122	ATPase activity
AK39_5096	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AK39_5098	COG0024	Methionine aminopeptidase
AK39_51	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AK39_5100	COG0201	protein transport
AK39_5105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AK39_512	COG4109	DRTGG domain
AK39_5126	COG1358	cellular component organization or biogenesis
AK39_5127	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AK39_5129	COG2813	Specifically methylates the guanine in position
AK39_5134	COG0250	Participates in transcription elongation, termination and antitermination
AK39_5135	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AK39_5137	COG3688	RNA-binding protein containing a PIN domain
AK39_5138	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AK39_5141	COG1045	serine acetyltransferase
AK39_5145	COG4956	integral membrane protein (PIN domain superfamily)
AK39_5147	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AK39_5148	COG0542	response to heat
AK39_5150	COG3880	PFAM UvrB UvrC protein
AK39_5157	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AK39_5158	COG1396	sequence-specific DNA binding
AK39_5159	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AK39_516	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AK39_5160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AK39_5161	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AK39_5162	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK39_5163	COG0512	Glutamine amidotransferase of anthranilate synthase
AK39_5164	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AK39_5165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AK39_5168	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AK39_5170	COG0037	tRNA processing
AK39_5171	COG2208	phosphoserine phosphatase activity
AK39_5174	COG1098	S1 RNA binding domain
AK39_5178	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AK39_5179	COG3956	TIGRFAM MazG family protein
AK39_5180	COG2244	polysaccharide biosynthetic process
AK39_5181	COG2002	toxin-antitoxin pair type II binding
AK39_5182	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AK39_5184	COG0193	aminoacyl-tRNA hydrolase activity
AK39_5185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AK39_5188	COG0251	oxidation-reduction process
AK39_5189	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AK39_519	COG0587	DNA-directed DNA polymerase activity
AK39_5192	COG4466	Protein conserved in bacteria
AK39_5195	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AK39_5196	COG0084	hydrolase, TatD family'
AK39_5197	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK39_5197	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK39_5198	COG2002	toxin-antitoxin pair type II binding
AK39_5199	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AK39_52	COG1252	NADH dehydrogenase
AK39_520	COG0281	malic enzyme
AK39_5201	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AK39_5203	COG1774	PSP1 C-terminal conserved region
AK39_5204	COG0470	DNA polymerase III
AK39_5206	COG1982	Orn Lys Arg decarboxylase major
AK39_521	COG1725	Transcriptional regulator
AK39_5218	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AK39_5219	COG0590	tRNA wobble adenosine to inosine editing
AK39_5220	COG1335	isochorismatase
AK39_5221	COG1428	Deoxynucleoside kinase
AK39_5222	COG1428	Deoxynucleoside kinase
AK39_5228	COG1686	Belongs to the peptidase S11 family
AK39_5229	COG0517	IMP dehydrogenase activity
AK39_5229	COG0516	GMP reductase activity
AK39_5237	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AK39_5238	COG0187	DNA topoisomerase II activity
AK39_5240	COG2501	S4 domain
AK39_5241	COG0592	DNA-directed DNA polymerase activity
AK39_5245	COG0706	membrane insertase activity
AK39_5246	COG1847	R3H domain protein
AK39_5247	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AK39_5251	COG1192	Involved in chromosome partitioning
AK39_5252	COG1475	DNA binding
AK39_5254	COG0668	transmembrane transport
AK39_5255	COG4481	Protein conserved in bacteria
AK39_5256	COG0012	GTP binding
AK39_5258	COG0629	single-stranded DNA binding
AK39_526	COG3030	protein affecting phage T7 exclusion by the F plasmid
AK39_5260	COG4241	membrane
AK39_5261	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AK39_5263	COG0305	Participates in initiation and elongation during chromosome replication
AK39_5269	COG0745	RESPONSE REGULATOR receiver
AK39_527	COG0628	permease
AK39_5270	COG5002	protein histidine kinase activity
AK39_5271	COG4863	YycH protein
AK39_5272	COG4853	Protein conserved in bacteria
AK39_5273	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AK39_5274	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AK39_5278	COG1164	Oligoendopeptidase f
AK39_5279	COG0516	GMP reductase activity
AK39_5283	COG1272	protein, Hemolysin III
AK39_5284	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AK39_5288	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AK39_5289	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AK39_529	COG0372	Belongs to the citrate synthase family
AK39_5290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AK39_5291	COG2814	Major facilitator Superfamily
AK39_5292	COG3275	phosphorelay sensor kinase activity
AK39_5293	COG3279	Response regulator of the LytR AlgR family
AK39_5296	COG0628	permease
AK39_5297	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AK39_5297	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AK39_5298	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AK39_5299	COG1309	transcriptional regulator
AK39_530	COG0538	isocitrate dehydrogenase activity
AK39_5300	COG0463	Glycosyl transferase, family 2
AK39_5305	COG0488	(ABC) transporter
AK39_5308	COG1607	acyl-coa hydrolase
AK39_5310	COG0840	transmembrane signaling receptor activity
AK39_5315	COG0477	Major facilitator Superfamily
AK39_5316	COG3279	Response regulator of the LytR AlgR family
AK39_5317	COG1966	Carbon starvation protein
AK39_5318	COG2879	small protein
AK39_5319	COG3706	GGDEF domain
AK39_5320	COG0351	phosphomethylpyrimidine kinase
AK39_5321	COG2203	Gaf domain
AK39_5321	COG4585	Histidine kinase
AK39_5322	COG4585	Histidine kinase
AK39_5322	COG2203	Gaf domain
AK39_5323	COG2197	response regulator
AK39_5325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AK39_5326	COG1011	Hydrolase
AK39_5330	COG0460	homoserine dehydrogenase
AK39_5332	COG1609	Transcriptional regulator
AK39_5333	COG2755	lipolytic protein G-D-S-L family
AK39_5334	COG1131	(ABC) transporter
AK39_5335	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AK39_5337	COG2814	Major facilitator Superfamily
AK39_5338	COG0561	phosphatase activity
AK39_5339	COG2233	PERMEase
AK39_534	COG0745	RESPONSE REGULATOR receiver
AK39_5340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AK39_5342	COG2363	Small membrane protein
AK39_5344	COG3773	Cell wall hydrolase
AK39_5347	COG0280	phosphate acetyltransferase
AK39_5348	COG0095	Lipoate-protein ligase
AK39_535	COG5002	protein histidine kinase activity
AK39_5352	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_5353	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_5354	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_5355	COG1120	ATPase activity
AK39_5356	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_5357	COG1078	dGTPase activity
AK39_5359	COG1994	Peptidase M50
AK39_536	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AK39_536	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AK39_5361	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK39_5362	COG0584	glycerophosphoryl diester phosphodiesterase
AK39_5363	COG0789	Transcriptional regulator
AK39_5364	COG2814	Major facilitator Superfamily
AK39_5365	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AK39_5366	COG0010	Belongs to the arginase family
AK39_5369	COG1619	proteins homologs of microcin C7 resistance protein MccF
AK39_537	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AK39_5370	COG4506	Protein conserved in bacteria
AK39_5371	COG0018	arginyl-trna synthetase
AK39_5372	COG1595	DNA-templated transcription, initiation
AK39_5376	COG2234	aminopeptidase activity
AK39_538	COG1971	Probably functions as a manganese efflux pump
AK39_5380	COG0024	Methionine aminopeptidase
AK39_5381	COG1131	(ABC) transporter
AK39_5382	COG0842	Transport permease protein
AK39_5383	COG4585	Histidine kinase
AK39_5384	COG2197	response regulator
AK39_5388	COG5001	Diguanylate cyclase
AK39_5388	COG3300	MHYT domain
AK39_539	COG0237	dephospho-CoA kinase activity
AK39_5390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK39_5391	COG0247	lactate metabolic process
AK39_5391	COG2181	nitrate reductase activity
AK39_5392	COG0183	Belongs to the thiolase family
AK39_5393	COG1250	3-hydroxyacyl-CoA dehydrogenase
AK39_5394	COG1960	acyl-CoA dehydrogenase activity
AK39_5395	COG1960	acyl-CoA dehydrogenase activity
AK39_5397	COG3343	RNA polymerase activity
AK39_5399	COG4821	SIS domain
AK39_54	COG1733	regulation of RNA biosynthetic process
AK39_540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AK39_5402	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AK39_5403	COG1494	fructose-1,6-bisphosphatase
AK39_5404	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AK39_5407	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AK39_5408	COG2890	protein-(glutamine-N5) methyltransferase activity
AK39_541	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AK39_5411	COG0009	L-threonylcarbamoyladenylate synthase
AK39_5414	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AK39_5415	COG2259	Doxx family
AK39_5416	COG2190	(PTS) system
AK39_5418	COG0698	ribose 5-phosphate isomerase
AK39_5424	COG0356	it plays a direct role in the translocation of protons across the membrane
AK39_543	COG3611	Membrane attachment protein
AK39_5434	COG5001	Diguanylate cyclase
AK39_5434	COG3300	MHYT domain
AK39_5435	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AK39_5437	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AK39_5438	COG0649	NAD binding
AK39_544	COG1484	DNA-dependent DNA replication
AK39_5441	COG0839	Belongs to the complex I subunit 6 family
AK39_5443	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AK39_5444	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AK39_5445	COG1007	ATP synthesis coupled electron transport
AK39_5446	COG4836	Membrane
AK39_5448	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AK39_5449	COG2385	sporulation resulting in formation of a cellular spore
AK39_5450	COG4555	ABC transporter
AK39_5451	COG3279	Response regulator of the LytR AlgR family
AK39_5454	COG0739	heme binding
AK39_5456	COG1609	Transcriptional regulator
AK39_546	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AK39_5465	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AK39_5466	COG1682	transport, permease protein
AK39_5467	COG1134	teichoic acid transport
AK39_5468	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AK39_547	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AK39_5471	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AK39_5472	COG0745	RESPONSE REGULATOR receiver
AK39_5473	COG5002	protein histidine kinase activity
AK39_5480	COG1136	(ABC) transporter
AK39_5481	COG0577	efflux transmembrane transporter activity
AK39_5483	COG1191	sigma factor activity
AK39_5489	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AK39_5490	COG4715	Zinc finger, swim domain protein
AK39_5495	COG1388	LysM domain
AK39_5495	COG3584	3D domain protein
AK39_5496	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AK39_55	COG2814	Major facilitator Superfamily
AK39_5501	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK39_5502	COG1388	LysM domain
AK39_5502	COG0791	NLP P60 protein
AK39_5505	COG1368	sulfuric ester hydrolase activity
AK39_5508	COG2389	metal-binding protein
AK39_551	COG1363	Peptidase, m42
AK39_5510	COG1620	l-lactate permease
AK39_5512	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AK39_5513	COG1294	oxidase, subunit
AK39_5514	COG1271	oxidase subunit
AK39_5517	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AK39_5518	COG0583	DNA-binding transcription factor activity
AK39_5519	COG1511	domain protein
AK39_552	COG1309	transcriptional regulator
AK39_5520	COG0346	lactoylglutathione lyase activity
AK39_5522	COG1301	dicarboxylic acid transport
AK39_5523	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AK39_5525	COG1447	Phosphotransferase system cellobiose-specific component IIA
AK39_5526	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AK39_5527	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AK39_5529	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AK39_553	COG1566	PFAM secretion protein HlyD family protein
AK39_5530	COG1447	Phosphotransferase system cellobiose-specific component IIA
AK39_5531	COG1486	melibiose metabolic process
AK39_5532	COG3394	polysaccharide catabolic process
AK39_5535	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AK39_5535	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AK39_5537	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AK39_5538	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AK39_5539	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AK39_554	COG2814	Major facilitator Superfamily
AK39_5540	COG1316	TRANSCRIPTIONal
AK39_5541	COG1739	Uncharacterized protein family UPF0029
AK39_5542	COG1307	EDD domain protein, DegV family
AK39_5543	COG1733	regulation of RNA biosynthetic process
AK39_5544	COG0791	NLP P60 protein
AK39_5544	COG1388	LysM domain
AK39_5545	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AK39_5546	COG1040	competence protein
AK39_5547	COG1278	Cold shock
AK39_5548	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AK39_5549	COG0653	protein targeting
AK39_5550	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AK39_5552	COG2884	Cell division ATP-binding protein ftsE
AK39_5553	COG2177	Part of the ABC transporter FtsEX involved in
AK39_5554	COG3409	Peptidoglycan-binding domain 1 protein
AK39_5554	COG0793	Belongs to the peptidase S41A family
AK39_5555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AK39_5556	COG1132	(ABC) transporter
AK39_5559	COG0655	NAD(P)H dehydrogenase (quinone) activity
AK39_5561	COG0583	DNA-binding transcription factor activity
AK39_5562	COG2855	membrane
AK39_5566	COG0789	Transcriptional regulator
AK39_5570	COG0556	nucleotide-excision repair
AK39_5571	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AK39_5573	COG1950	PFAM Membrane protein of
AK39_5577	COG0110	maltose O-acetyltransferase activity
AK39_5578	COG0457	Tetratricopeptide repeat
AK39_5579	COG0492	ferredoxin-NADP+ reductase activity
AK39_5581	COG1051	belongs to the nudix hydrolase family
AK39_5583	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AK39_5585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AK39_5586	COG0740	serine-type endopeptidase activity
AK39_5587	COG2323	membrane
AK39_559	COG1418	mRNA catabolic process
AK39_5590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK39_5595	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AK39_56	COG0656	L-ascorbic acid biosynthetic process
AK39_5603	COG3344	reverse transcriptase
AK39_561	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AK39_563	COG0072	phenylalanine-tRNA ligase activity
AK39_563	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK39_564	COG0017	Asparaginyl-tRNA synthetase
AK39_5649	COG4962	Type ii secretion system protein e
AK39_5680	COG2311	Membrane
AK39_5686	COG4196	transglutaminase domain protein
AK39_5687	COG0671	phosphoesterase, PA-phosphatase related
AK39_5691	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AK39_5692	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AK39_5696	COG2801	Transposase and inactivated derivatives
AK39_570	COG1286	toxin biosynthetic process
AK39_571	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AK39_571	COG1796	DNA polymerase
AK39_5730	COG2002	toxin-antitoxin pair type II binding
AK39_5732	COG4974	Belongs to the 'phage' integrase family
AK39_574	COG1187	pseudouridine synthase activity
AK39_5741	COG2801	Transposase and inactivated derivatives
AK39_5745	COG2801	Transposase and inactivated derivatives
AK39_5747	COG3443	Belongs to the bacterial solute-binding protein 9 family
AK39_5749	COG4974	Belongs to the 'phage' integrase family
AK39_575	COG1114	Component of the transport system for branched-chain amino acids
AK39_5754	COG0457	Tetratricopeptide repeat
AK39_5756	COG1923	regulation of RNA biosynthetic process
AK39_576	COG5386	Cell surface protein
AK39_5777	COG3344	reverse transcriptase
AK39_578	COG5386	Cell surface protein
AK39_581	COG1120	ATPase activity
AK39_582	COG4509	Sortase family
AK39_585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AK39_586	COG4895	conserved protein (DUF2196)
AK39_588	COG0745	RESPONSE REGULATOR receiver
AK39_589	COG2205	protein histidine kinase activity
AK39_590	COG1131	(ABC) transporter
AK39_596	COG2318	DinB family
AK39_600	COG0318	PFAM AMP-dependent synthetase and ligase
AK39_601	COG1309	transcriptional regulator
AK39_602	COG1024	Enoyl-CoA hydratase
AK39_603	COG2086	electron transfer activity
AK39_604	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AK39_605	COG3118	belongs to the thioredoxin family
AK39_607	COG1719	4-vinyl reductase, 4VR
AK39_608	COG2009	succinate dehydrogenase
AK39_609	COG1053	succinate dehydrogenase
AK39_61	COG2910	NAD(P)H-binding
AK39_610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AK39_611	COG0824	Thioesterase
AK39_612	COG1876	peptidase activity
AK39_613	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AK39_614	COG1360	Flagellar Motor Protein
AK39_615	COG1360	Flagellar Motor Protein
AK39_616	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AK39_617	COG4152	abc transporter atp-binding protein
AK39_618	COG1668	transmembrane transport
AK39_619	COG1959	2 iron, 2 sulfur cluster binding
AK39_62	COG1115	amino acid carrier protein
AK39_621	COG0697	spore germination
AK39_622	COG1396	sequence-specific DNA binding
AK39_623	COG1983	PspC domain protein
AK39_626	COG3279	Response regulator of the LytR AlgR family
AK39_627	COG3275	phosphorelay sensor kinase activity
AK39_628	COG4608	Belongs to the ABC transporter superfamily
AK39_629	COG0444	Belongs to the ABC transporter superfamily
AK39_63	COG1115	amino acid carrier protein
AK39_633	COG0402	S-adenosylhomocysteine deaminase activity
AK39_634	COG0402	S-adenosylhomocysteine deaminase activity
AK39_636	COG2233	PERMEase
AK39_637	COG2197	response regulator
AK39_64	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK39_640	COG1309	transcriptional regulator
AK39_644	COG5401	PFAM Sporulation and spore germination
AK39_646	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AK39_647	COG0622	Phosphoesterase
AK39_65	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK39_657	COG0470	DNA polymerase III
AK39_657	COG1067	ATP-dependent peptidase activity
AK39_660	COG1764	response to oxidative stress
AK39_661	COG1846	Transcriptional regulator
AK39_663	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AK39_665	COG1587	Uroporphyrinogen-III synthase
AK39_666	COG0113	porphobilinogen synthase activity
AK39_668	COG1388	LysM domain
AK39_67	COG2311	Membrane
AK39_670	COG0525	valine-tRNA ligase activity
AK39_671	COG0285	dihydrofolate synthase activity
AK39_675	COG1077	Cell shape determining protein MreB Mrl
AK39_676	COG1792	Involved in formation and maintenance of cell shape
AK39_679	COG2894	cell division
AK39_680	COG0739	heme binding
AK39_681	COG1994	Peptidase M50
AK39_682	COG1530	ribonuclease E activity
AK39_684	COG2868	ribosomal protein
AK39_686	COG3290	protein histidine kinase activity
AK39_687	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AK39_688	COG0745	RESPONSE REGULATOR receiver
AK39_690	COG5002	protein histidine kinase activity
AK39_691	COG1136	(ABC) transporter
AK39_692	COG0577	efflux transmembrane transporter activity
AK39_693	COG0577	efflux transmembrane transporter activity
AK39_694	COG0077	Prephenate dehydratase
AK39_695	COG2258	MOSC domain
AK39_696	COG1827	regulation of RNA biosynthetic process
AK39_697	COG1104	cysteine desulfurase activity
AK39_698	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AK39_699	COG0157	Belongs to the NadC ModD family
AK39_70	COG1611	Belongs to the LOG family
AK39_704	COG0640	Transcriptional regulator
AK39_705	COG0697	spore germination
AK39_706	COG0697	spore germination
AK39_708	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AK39_714	COG1862	Preprotein translocase
AK39_716	COG2323	membrane
AK39_717	COG2244	polysaccharide biosynthetic process
AK39_719	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AK39_719	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AK39_720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AK39_721	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AK39_721	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AK39_723	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AK39_726	COG0124	histidyl-tRNA synthetase
AK39_728	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AK39_73	COG0783	Belongs to the Dps family
AK39_730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AK39_731	COG1959	2 iron, 2 sulfur cluster binding
AK39_732	COG1104	cysteine desulfurase activity
AK39_733	COG0482	sulfurtransferase activity
AK39_735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AK39_739	COG0628	permease
AK39_74	COG1115	amino acid carrier protein
AK39_741	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AK39_745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AK39_75	COG0490	domain, Protein
AK39_751	COG0768	penicillin binding
AK39_756	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AK39_757	COG0626	cystathionine gamma-synthase activity
AK39_758	COG1012	belongs to the aldehyde dehydrogenase family
AK39_758	COG1454	alcohol dehydrogenase
AK39_76	COG0475	glutathione-regulated potassium exporter activity
AK39_760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_768	COG2259	Doxx family
AK39_769	COG2514	catechol 2,3-dioxygenase activity
AK39_770	COG2514	catechol 2,3-dioxygenase activity
AK39_772	COG3186	Phenylalanine-4-hydroxylase
AK39_773	COG1404	Belongs to the peptidase S8 family
AK39_780	COG2267	carboxylic ester hydrolase activity
AK39_782	COG1785	Belongs to the alkaline phosphatase family
AK39_784	COG2357	RelA SpoT domain protein
AK39_785	COG0778	Nitroreductase
AK39_787	COG1595	DNA-templated transcription, initiation
AK39_79	COG1741	Belongs to the pirin family
AK39_790	COG1191	sigma factor activity
AK39_793	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AK39_794	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AK39_796	COG1534	Rna-binding protein
AK39_798	COG1713	HD superfamily hydrolase involved in NAD metabolism
AK39_799	COG0799	negative regulation of ribosome biogenesis
AK39_80	COG3227	Zinc metalloprotease (Elastase)
AK39_800	COG2226	methyltransferase
AK39_801	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK39_802	COG1555	photosystem II stabilization
AK39_802	COG1596	polysaccharide export
AK39_803	COG2131	deaminase
AK39_807	COG1466	dna polymerase III delta subunit
AK39_81	COG2151	metal-sulfur cluster biosynthetic enzyme
AK39_812	COG1733	regulation of RNA biosynthetic process
AK39_813	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AK39_815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AK39_819	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AK39_820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AK39_822	COG1610	YqeY-like protein
AK39_825	COG1702	phosphate starvation-inducible protein PhoH
AK39_826	COG1480	7TM receptor with intracellular HD hydrolase
AK39_828	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AK39_829	COG0295	cytidine deaminase activity
AK39_830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AK39_833	COG0517	IMP dehydrogenase activity
AK39_835	COG0358	DNA primase activity
AK39_836	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AK39_837	COG2010	Cytochrome c
AK39_838	COG2384	SAM-dependent methyltransferase
AK39_839	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AK39_84	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK39_845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_846	COG1121	(ABC) transporter
AK39_847	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AK39_848	COG0735	belongs to the Fur family
AK39_853	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AK39_854	COG0477	Major facilitator Superfamily
AK39_856	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AK39_857	COG0573	inorganic phosphate transmembrane transporter activity
AK39_858	COG0581	inorganic phosphate transmembrane transporter activity
AK39_859	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AK39_86	COG5002	protein histidine kinase activity
AK39_860	COG0704	Plays a role in the regulation of phosphate uptake
AK39_861	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AK39_863	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AK39_864	COG4483	Protein conserved in bacteria
AK39_865	COG1940	carbohydrate kinase activity
AK39_867	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_87	COG0745	RESPONSE REGULATOR receiver
AK39_871	COG0626	cystathionine gamma-synthase activity
AK39_872	COG0626	cystathionine gamma-synthase activity
AK39_873	COG0646	methionine synthase
AK39_873	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AK39_874	COG1410	methionine synthase
AK39_874	COG0646	methionine synthase
AK39_875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AK39_88	COG1376	ErfK ybiS ycfS ynhG family protein
AK39_885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AK39_886	COG1459	type II secretion system
AK39_888	COG4970	Tfp pilus assembly protein FimT
AK39_899	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AK39_90	COG0586	Pfam SNARE associated Golgi protein
AK39_905	COG1725	Transcriptional regulator
AK39_906	COG1131	(ABC) transporter
AK39_913	COG2076	Multidrug Resistance protein
AK39_914	COG2076	Multidrug Resistance protein
AK39_916	COG1609	Transcriptional regulator
AK39_917	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK39_918	COG0095	Lipoate-protein ligase
AK39_923	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AK39_924	COG3872	metal-dependent enzyme
AK39_927	COG0006	proline dipeptidase activity
AK39_932	COG3854	ATPases associated with a variety of cellular activities
AK39_941	COG0511	ligase activity, forming carbon-carbon bonds
AK39_942	COG0439	Biotin carboxylase
AK39_943	COG1302	Protein conserved in bacteria
AK39_948	COG0142	geranyltranstransferase activity
AK39_950	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AK39_952	COG0497	DNA recombination
AK39_953	COG0750	zinc metalloprotease
AK39_954	COG0745	RESPONSE REGULATOR receiver
AK39_956	COG3093	addiction module antidote protein HigA
AK39_957	COG0584	glycerophosphoryl diester phosphodiesterase
AK39_959	COG3290	protein histidine kinase activity
AK39_959	COG3829	transcription factor binding
AK39_960	COG0280	phosphate acetyltransferase
AK39_961	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AK39_963	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AK39_964	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AK39_965	COG0022	dehydrogenase e1 component
AK39_966	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK39_967	COG0772	Belongs to the SEDS family
AK39_968	COG2816	NAD+ diphosphatase activity
AK39_97	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_971	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK39_972	COG0765	amino acid transport
AK39_973	COG1126	abc transporter atp-binding protein
AK39_974	COG4129	membrane
AK39_975	COG1376	ErfK ybiS ycfS ynhG family protein
AK39_977	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_978	COG2195	Cleaves the N-terminal amino acid of tripeptides
AK39_980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AK39_983	COG1760	l-serine dehydratase
AK39_984	COG1760	l-serine dehydratase
AK39_985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK39_987	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_988	COG0300	oxidoreductase activity
AK39_99	COG0706	membrane insertase activity
AK39_991	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AK39_993	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AK39_997	COG1522	sequence-specific DNA binding
AK39_999	COG0737	Belongs to the 5'-nucleotidase family