locus-tag	class	description
K6959_00070	COG0772	Belongs to the SEDS family
K6959_00075	COG2239	Acts as a magnesium transporter
K6959_00095	COG2076	Multidrug Resistance protein
K6959_00100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6959_00105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6959_00110	COG1120	ATPase activity
K6959_00115	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K6959_00125	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
K6959_00130	COG1492	cobalamin metabolic process
K6959_00135	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K6959_00140	COG0588	phosphoglycerate mutase activity
K6959_00150	COG2096	Adenosyltransferase
K6959_00165	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6959_00170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6959_00180	COG0513	Belongs to the DEAD box helicase family
K6959_00195	COG3402	PFAM membrane-flanked domain
K6959_00200	COG3428	Bacterial PH domain
K6959_00205	COG0705	Rhomboid family
K6959_00210	COG0736	holo-[acyl-carrier-protein] synthase activity
K6959_00215	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K6959_00225	COG0864	Transcriptional regulator
K6959_00230	COG2337	Toxic component of a toxin-antitoxin (TA) module
K6959_00235	COG2172	sigma factor antagonist activity
K6959_00240	COG2208	phosphoserine phosphatase activity
K6959_00245	COG1366	Belongs to the anti-sigma-factor antagonist family
K6959_00250	COG2172	sigma factor antagonist activity
K6959_00255	COG1191	sigma factor activity
K6959_00260	COG2183	response to ionizing radiation
K6959_00270	COG3091	SprT-like family
K6959_00345	COG0802	atpase or kinase
K6959_00350	COG1214	PFAM Peptidase M22, glycoprotease
K6959_00355	COG0456	acetyltransferase
K6959_00365	COG0488	(ABC) transporter
K6959_00370	COG0315	cyclic pyranopterin monophosphate synthase activity
K6959_00375	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K6959_00380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6959_00385	COG0805	protein transport
K6959_00395	COG1266	CAAX protease self-immunity
K6959_00400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6959_00405	COG0459	protein refolding
K6959_00415	COG1396	sequence-specific DNA binding
K6959_00470	COG0419	ATPase involved in DNA repair
K6959_00510	COG1309	transcriptional regulator
K6959_00515	COG2814	Major facilitator Superfamily
K6959_00525	COG0577	efflux transmembrane transporter activity
K6959_00525	COG1136	(ABC) transporter
K6959_00530	COG1335	isochorismatase
K6959_00540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K6959_00565	COG1028	Short-chain dehydrogenase reductase Sdr
K6959_00570	COG1028	Short-chain dehydrogenase reductase Sdr
K6959_00580	COG1469	GTP cyclohydrolase I activity
K6959_00645	COG4106	trans-aconitate 2-methyltransferase activity
K6959_00660	COG0477	Major facilitator Superfamily
K6959_00665	COG2132	Multicopper oxidase
K6959_00690	COG1131	(ABC) transporter
K6959_00715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6959_00760	COG2972	Histidine kinase
K6959_00760	COG0745	RESPONSE REGULATOR receiver
K6959_00765	COG3279	Response regulator of the LytR AlgR family
K6959_00775	COG3764	Sortase (surface protein transpeptidase)
K6959_00790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6959_00795	COG0531	amino acid
K6959_00805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K6959_00805	COG0515	serine threonine protein kinase
K6959_00820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6959_00830	COG1396	sequence-specific DNA binding
K6959_00860	COG1396	sequence-specific DNA binding
K6959_00865	COG1476	TRANSCRIPTIONal
K6959_00910	COG0714	Associated with various cellular activities
K6959_00915	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
K6959_00920	COG1305	Transglutaminase-like
K6959_00925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6959_00925	COG0519	Catalyzes the synthesis of GMP from XMP
K6959_00930	COG4974	Belongs to the 'phage' integrase family
K6959_00965	COG0745	RESPONSE REGULATOR receiver
K6959_00970	COG5002	protein histidine kinase activity
K6959_00985	COG1959	2 iron, 2 sulfur cluster binding
K6959_00995	COG2252	PERMEase
K6959_01015	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6959_01020	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K6959_01025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K6959_01030	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6959_01035	COG0047	phosphoribosylformylglycinamidine synthase activity
K6959_01040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6959_01045	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6959_01050	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K6959_01055	COG0138	bifunctional purine biosynthesis protein purh
K6959_01060	COG0151	Belongs to the GarS family
K6959_01075	COG1470	cell adhesion involved in biofilm formation
K6959_01080	COG4496	protein, YerC YecD
K6959_01085	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
K6959_01090	COG0210	DNA helicase
K6959_01100	COG0210	DNA helicase
K6959_01105	COG0210	DNA helicase
K6959_01110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6959_01115	COG4851	CamS sex pheromone cAM373 precursor
K6959_01125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6959_01130	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K6959_01135	COG2224	Isocitrate lyase
K6959_01160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K6959_01165	COG0154	amidase activity
K6959_01170	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K6959_01175	COG5444	nuclease activity
K6959_01230	COG5444	nuclease activity
K6959_01260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6959_01275	COG2190	(PTS) system
K6959_01280	COG3711	transcriptional antiterminator
K6959_01285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6959_01285	COG1263	PTS System
K6959_01330	COG1597	lipid kinase activity
K6959_01440	COG1802	Transcriptional regulator
K6959_01440	COG4626	Terminase
K6959_01460	COG4695	Portal protein
K6959_01465	COG0740	serine-type endopeptidase activity
K6959_01485	COG1595	DNA-templated transcription, initiation
K6959_01515	COG3173	Aminoglycoside phosphotransferase
K6959_01690	COG1733	regulation of RNA biosynthetic process
K6959_01835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6959_01840	COG0583	DNA-binding transcription factor activity
K6959_01855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6959_01895	COG0154	amidase activity
K6959_01900	COG2244	polysaccharide biosynthetic process
K6959_01905	COG4187	Peptidase family M20/M25/M40
K6959_01910	COG0670	Belongs to the BI1 family
K6959_01915	COG1970	mechanosensitive ion channel activity
K6959_01925	COG4145	pantothenate transmembrane transporter activity
K6959_01930	COG2309	aminopeptidase activity
K6959_01965	COG1131	(ABC) transporter
K6959_01975	COG1105	Belongs to the carbohydrate kinase PfkB family
K6959_01980	COG2313	pseudouridylate synthase activity
K6959_01985	COG0024	Methionine aminopeptidase
K6959_02000	COG5002	protein histidine kinase activity
K6959_02005	COG2204	response regulator
K6959_02010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6959_02025	COG0243	molybdopterin cofactor binding
K6959_02035	COG4840	Belongs to the UPF0435 family
K6959_02040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6959_02050	COG1295	ribonuclease BN
K6959_02055	COG2217	Heavy metal translocating P-type atpase
K6959_02070	COG2602	Beta-lactamase
K6959_02075	COG1595	DNA-templated transcription, initiation
K6959_02250	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K6959_02280	COG0196	riboflavin kinase activity
K6959_02315	COG1942	4-Oxalocrotonate Tautomerase
K6959_02325	COG0633	Ferredoxin
K6959_02325	COG0543	2 iron, 2 sulfur cluster binding
K6959_02370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K6959_02375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6959_02400	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
K6959_02420	COG1966	Carbon starvation protein
K6959_02425	COG1268	BioY protein
K6959_02510	COG1988	membrane-bound metal-dependent
K6959_02515	COG1194	a g-specific adenine glycosylase
K6959_02525	COG1028	Short-chain dehydrogenase reductase Sdr
K6959_02540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6959_02575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6959_02585	COG0671	phosphoesterase, PA-phosphatase related
K6959_02590	COG3835	regulator
K6959_02595	COG1012	belongs to the aldehyde dehydrogenase family
K6959_02600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6959_02605	COG2358	TRAP transporter, solute receptor (TAXI family
K6959_02630	COG3557	Belongs to the UPF0374 family
K6959_02650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K6959_02660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6959_02665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6959_02670	COG2096	Adenosyltransferase
K6959_02675	COG0735	belongs to the Fur family
K6959_02790	COG2367	Beta-lactamase
K6959_02830	COG3339	Conserved Protein
K6959_02845	COG3279	Response regulator of the LytR AlgR family
K6959_02855	COG1733	regulation of RNA biosynthetic process
K6959_02880	COG5444	nuclease activity
K6959_02900	COG3655	Transcriptional regulator
K6959_02915	COG3382	B3 4 domain protein
K6959_02920	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6959_02930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K6959_02935	COG0778	Nitroreductase
K6959_02960	COG4758	membrane
K6959_02965	COG4585	Histidine kinase
K6959_02970	COG2197	response regulator
K6959_02975	COG2766	serine protein kinase
K6959_02985	COG0789	Transcriptional regulator
K6959_02990	COG1607	acyl-coa hydrolase
K6959_02995	COG2718	Belongs to the UPF0229 family
K6959_03000	COG0281	malic enzyme
K6959_03005	COG1823	symporter activity
K6959_03015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6959_03020	COG1858	cytochrome C peroxidase
K6959_03025	COG0656	L-ascorbic acid biosynthetic process
K6959_03030	COG1741	Belongs to the pirin family
K6959_03035	COG0655	NAD(P)H dehydrogenase (quinone) activity
K6959_03055	COG5444	nuclease activity
K6959_03085	COG5444	nuclease activity
K6959_03110	COG0564	pseudouridine synthase activity
K6959_03115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6959_03120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6959_03125	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K6959_03130	COG4585	Histidine kinase
K6959_03130	COG2203	Gaf domain
K6959_03135	COG2197	response regulator
K6959_03155	COG1136	(ABC) transporter
K6959_03155	COG0577	efflux transmembrane transporter activity
K6959_03165	COG0745	RESPONSE REGULATOR receiver
K6959_03180	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K6959_03185	COG0406	alpha-ribazole phosphatase activity
K6959_03200	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K6959_03205	COG1253	flavin adenine dinucleotide binding
K6959_03210	COG0789	Transcriptional regulator
K6959_03225	COG3852	Histidine kinase
K6959_03230	COG3859	Proton-coupled thiamine transporter YuaJ
K6959_03235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6959_03240	COG2814	Major facilitator Superfamily
K6959_03245	COG1595	DNA-templated transcription, initiation
K6959_03260	COG0393	Putative heavy-metal-binding
K6959_03280	COG3842	ATPase activity
K6959_03285	COG2508	Transcriptional regulator
K6959_03290	COG1937	Protein conserved in bacteria
K6959_03310	COG0189	ligase activity
K6959_03325	COG4399	Belongs to the UPF0754 family
K6959_03330	COG3679	Belongs to the UPF0342 family
K6959_03335	COG0561	phosphatase activity
K6959_03340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6959_03345	COG0318	PFAM AMP-dependent synthetase and ligase
K6959_03350	COG0109	protoheme IX farnesyltransferase activity
K6959_03355	COG1024	Enoyl-CoA hydratase
K6959_03365	COG0444	Belongs to the ABC transporter superfamily
K6959_03370	COG4608	Belongs to the ABC transporter superfamily
K6959_03380	COG0601	transmembrane transport
K6959_03385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6959_03390	COG4152	abc transporter atp-binding protein
K6959_03395	COG1668	transmembrane transport
K6959_03405	COG4717	serine-type aminopeptidase activity
K6959_03415	COG2814	Major facilitator Superfamily
K6959_03420	COG3481	metal-dependent phosphohydrolase, HD sub domain
K6959_03430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6959_03445	COG1846	Transcriptional regulator
K6959_03465	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6959_03470	COG0537	adenosine 5'-monophosphoramidase activity
K6959_03475	COG1131	(ABC) transporter
K6959_03480	COG4473	ABC transporter
K6959_03490	COG1473	amidohydrolase
K6959_03495	COG3069	C4-dicarboxylate transmembrane transporter activity
K6959_03505	COG4585	Histidine kinase
K6959_03510	COG2197	response regulator
K6959_03520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K6959_03525	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K6959_03530	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K6959_03535	COG1309	transcriptional regulator
K6959_03540	COG1511	domain protein
K6959_03550	COG1234	tRNA 3'-trailer cleavage
K6959_03555	COG0095	Lipoate-protein ligase
K6959_03560	COG0318	PFAM AMP-dependent synthetase and ligase
K6959_03565	COG1024	Enoyl-CoA hydratase
K6959_03585	COG1122	ATPase activity
K6959_03590	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
K6959_03605	COG0501	Belongs to the peptidase M48B family
K6959_03615	COG4903	ComK protein
K6959_03630	COG1506	peptidase
K6959_03630	COG4946	Tricorn protease homolog
K6959_03630	COG0823	Involved in the tonB-independent uptake of proteins
K6959_03645	COG0398	Pfam SNARE associated Golgi protein
K6959_03675	COG0559	Belongs to the binding-protein-dependent transport system permease family
K6959_03680	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6959_03690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6959_03700	COG1028	Short-chain dehydrogenase reductase Sdr
K6959_03705	COG0183	Belongs to the thiolase family
K6959_03715	COG1051	belongs to the nudix hydrolase family
K6959_03715	COG1056	cytidyltransferase-related domain
K6959_03720	COG1335	isochorismatase
K6959_03725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K6959_03730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6959_03740	COG3344	reverse transcriptase
K6959_03745	COG0318	PFAM AMP-dependent synthetase and ligase
K6959_03750	COG3344	reverse transcriptase
K6959_03755	COG0471	metal ion transport
K6959_03760	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K6959_03765	COG1074	ATP-dependent DNA helicase activity
K6959_03770	COG1074	ATP-dependent DNA helicase activity
K6959_03805	COG0318	PFAM AMP-dependent synthetase and ligase
K6959_03825	COG0366	Alpha amylase catalytic
K6959_03825	COG1874	Beta-galactosidase
K6959_03830	COG1666	GTP binding
K6959_03835	COG5444	nuclease activity
K6959_03905	COG2996	Protein conserved in bacteria
K6959_03915	COG1307	EDD domain protein, DegV family
K6959_03920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6959_03935	COG0561	phosphatase activity
K6959_03940	COG1073	alpha beta
K6959_03945	COG2151	metal-sulfur cluster biosynthetic enzyme
K6959_03950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6959_03955	COG0303	'Molybdopterin
K6959_03960	COG1763	Mo-molybdopterin cofactor biosynthetic process
K6959_03970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6959_03975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6959_03980	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K6959_03995	COG0505	Belongs to the CarA family
K6959_04005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K6959_04020	COG0542	response to heat
K6959_04030	COG2267	carboxylic ester hydrolase activity
K6959_04040	COG1744	ABC transporter substrate-binding protein PnrA-like
K6959_04050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6959_04055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6959_04060	COG5504	Zn-dependent protease
K6959_04065	COG0444	Belongs to the ABC transporter superfamily
K6959_04070	COG4608	Belongs to the ABC transporter superfamily
K6959_04080	COG0601	transmembrane transport
K6959_04085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6959_04100	COG0180	Tryptophanyl-tRNA synthetase
K6959_04105	COG4166	transmembrane transport
K6959_04110	COG0601	transmembrane transport
K6959_04115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6959_04120	COG0444	Belongs to the ABC transporter superfamily
K6959_04125	COG4608	Belongs to the ABC transporter superfamily
K6959_04135	COG1393	Belongs to the ArsC family
K6959_04140	COG4862	establishment of competence for transformation
K6959_04150	COG4469	Competence protein
K6959_04160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K6959_04165	COG2346	COG2346, Truncated hemoglobins
K6959_04170	COG4116	CYTH
K6959_04180	COG2357	RelA SpoT domain protein
K6959_04190	COG0564	pseudouridine synthase activity
K6959_04250	COG0463	Glycosyl transferase, family 2
K6959_04265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K6959_04270	COG2239	Acts as a magnesium transporter
K6959_04275	COG1136	(ABC) transporter
K6959_04285	COG0577	efflux transmembrane transporter activity
K6959_04295	COG0745	RESPONSE REGULATOR receiver
K6959_04300	COG2205	protein histidine kinase activity
K6959_04335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6959_04355	COG2153	protein acetylation
K6959_04360	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K6959_04365	COG2382	esterase
K6959_04370	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6959_04375	COG2358	TRAP transporter, solute receptor (TAXI family
K6959_04395	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K6959_04400	COG4942	peptidase
K6959_04415	COG2856	Zn peptidase
K6959_04420	COG1396	sequence-specific DNA binding
K6959_04430	COG3561	AntA/AntB antirepressor
K6959_04440	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K6959_04480	COG1263	PTS System
K6959_04480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6959_04485	COG3344	reverse transcriptase
K6959_04495	COG1737	Transcriptional regulator
K6959_04505	COG1368	sulfuric ester hydrolase activity
K6959_04510	COG4412	M6 family metalloprotease domain protein
K6959_04510	COG1404	Belongs to the peptidase S8 family
K6959_04515	COG1595	DNA-templated transcription, initiation
K6959_04535	COG3344	reverse transcriptase
K6959_04545	COG3773	Cell wall hydrolase
K6959_04550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6959_04575	COG1525	nuclease
K6959_04610	COG1757	Na H antiporter
K6959_04615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6959_04620	COG1309	transcriptional regulator
K6959_04625	COG0861	Integral membrane protein TerC family
K6959_04635	COG0247	lactate metabolic process
K6959_04640	COG0277	FAD linked oxidase domain protein
K6959_04645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6959_04690	COG5002	protein histidine kinase activity
K6959_04695	COG0745	RESPONSE REGULATOR receiver
K6959_04700	COG1683	Conserved Protein
K6959_04715	COG0674	pyruvate-flavodoxin oxidoreductase activity
K6959_04725	COG5002	protein histidine kinase activity
K6959_04730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6959_04750	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K6959_04755	COG0644	oxidoreductase
K6959_04770	COG2223	nitrite transmembrane transporter activity
K6959_04780	COG1846	Transcriptional regulator
K6959_04790	COG0542	response to heat
K6959_04795	COG3949	Membrane
K6959_04805	COG4873	Protein conserved in bacteria
K6959_04810	COG2409	Drug exporters of the RND superfamily
K6959_04815	COG0129	dihydroxy-acid dehydratase activity
K6959_04835	COG1028	Short-chain dehydrogenase reductase Sdr
K6959_04915	COG2084	Dehydrogenase
K6959_04925	COG1714	RDD family
K6959_04935	COG1376	ErfK ybiS ycfS ynhG family protein
K6959_04940	COG1408	metallophosphoesterase
K6959_04945	COG1028	Short-chain dehydrogenase reductase Sdr
K6959_04950	COG4990	cell redox homeostasis
K6959_04965	COG4703	Protein of unknown function (DUF1797)
K6959_04975	COG0517	IMP dehydrogenase activity
K6959_04985	COG0450	alkyl hydroperoxide reductase
K6959_04990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6959_05005	COG0569	domain protein
K6959_05010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K6959_05020	COG0242	peptide deformylase activity
K6959_05055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6959_05080	COG1982	Orn Lys Arg decarboxylase major
K6959_05090	COG4476	Belongs to the UPF0223 family
K6959_05095	COG4493	Belongs to the UPF0637 family
K6959_05105	COG0483	inositol monophosphate 1-phosphatase activity
K6959_05115	COG1217	gtp-binding protein TYPA
K6959_05130	COG4896	Protein conserved in bacteria
K6959_05155	COG2066	Belongs to the glutaminase family
K6959_05160	COG4838	Belongs to the UPF0358 family
K6959_05170	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K6959_05175	COG1612	heme a metabolic process
K6959_05205	COG3336	cytochrome c oxidase
K6959_05220	COG0628	permease
K6959_05230	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
K6959_05240	COG2340	Cysteine-rich secretory protein family
K6959_05260	COG3679	Belongs to the UPF0342 family
K6959_05265	COG4471	UPF0298 protein
K6959_05270	COG5444	nuclease activity
K6959_05325	COG0742	ribosomal rna small subunit methyltransferase
K6959_05330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6959_05335	COG3314	Sporulation integral membrane protein YlbJ
K6959_05340	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6959_05345	COG3480	Lon protease (S16) C-terminal proteolytic domain
K6959_05350	COG1323	Belongs to the UPF0348 family
K6959_05355	COG1399	metal-binding, possibly nucleic acid-binding protein
K6959_05360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K6959_05365	COG1024	Enoyl-CoA hydratase
K6959_05375	COG0454	-acetyltransferase
K6959_05380	COG0439	Biotin carboxylase
K6959_05385	COG0511	ligase activity, forming carbon-carbon bonds
K6959_05390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6959_05395	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6959_05425	COG0768	penicillin binding
K6959_05430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6959_05440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6959_05450	COG0772	Belongs to the SEDS family
K6959_05465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K6959_05470	COG3879	Bacterial protein of unknown function (DUF881)
K6959_05475	COG3879	Bacterial protein of unknown function (DUF881)
K6959_05480	COG3856	small basic protein
K6959_05485	COG0849	cell division
K6959_05490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6959_05500	COG1191	sigma factor activity
K6959_05505	COG1191	sigma factor activity
K6959_05510	COG1873	PFAM PRC-barrel domain
K6959_05520	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6959_05525	COG1799	cell septum assembly
K6959_05530	COG0762	integral membrane protein
K6959_05535	COG2302	S4 RNA-binding domain
K6959_05540	COG3599	regulation of cell shape
K6959_05545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K6959_05555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K6959_05560	COG0564	pseudouridine synthase activity
K6959_05565	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K6959_05570	COG2233	PERMEase
K6959_05575	COG0540	Belongs to the ATCase OTCase family
K6959_05590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6959_05595	COG0543	2 iron, 2 sulfur cluster binding
K6959_05600	COG0167	dihydroorotate dehydrogenase activity
K6959_05610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6959_05665	COG5444	nuclease activity
K6959_05675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K6959_05680	COG1561	YicC-like family, N-terminal region
K6959_05690	COG0194	GDP metabolic process
K6959_05695	COG1758	RNA polymerase activity
K6959_05705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6959_05710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6959_05720	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K6959_05725	COG0631	protein serine/threonine phosphatase activity
K6959_05730	COG0515	serine threonine protein kinase
K6959_05730	COG2815	serine threonine protein kinase
K6959_05740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6959_05745	COG1564	THIamine pyrophosphokinase
K6959_05755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K6959_05760	COG1302	Protein conserved in bacteria
K6959_05765	COG1461	Dihydroxyacetone kinase
K6959_05770	COG1760	l-serine dehydratase
K6959_05775	COG1760	l-serine dehydratase
K6959_05780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6959_05785	COG1349	DNA-binding transcription factor activity
K6959_05790	COG0416	fatty acid biosynthetic process
K6959_05795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K6959_05800	COG1028	Short-chain dehydrogenase reductase Sdr
K6959_05805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6959_05810	COG0571	ribonuclease III activity
K6959_05815	COG1196	nuclear chromosome segregation
K6959_05820	COG0552	protein localization to endoplasmic reticulum
K6959_05880	COG1131	(ABC) transporter
K6959_05905	COG0714	Associated with various cellular activities
K6959_05925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6959_05930	COG0228	four-way junction DNA binding
K6959_05935	COG1837	Belongs to the UPF0109 family
K6959_05945	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6959_05950	COG0336	Belongs to the RNA methyltransferase TrmD family
K6959_05955	COG0335	large ribosomal subunit rRNA binding
K6959_05965	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K6959_05970	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K6959_05975	COG0045	succinate-CoA ligase (ADP-forming) activity
K6959_05980	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K6959_05985	COG0758	DNA mediated transformation
K6959_05990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6959_05995	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K6959_06000	COG4974	Belongs to the 'phage' integrase family
K6959_06005	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K6959_06010	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K6959_06015	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K6959_06020	COG0052	Belongs to the universal ribosomal protein uS2 family
K6959_06025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6959_06030	COG0528	UMP kinase activity
K6959_06035	COG0233	cytoplasmic translational termination
K6959_06045	COG4589	Belongs to the CDS family
K6959_06055	COG0750	zinc metalloprotease
K6959_06060	COG0442	prolyl-tRNA aminoacylation
K6959_06075	COG0779	Required for maturation of 30S ribosomal subunits
K6959_06080	COG0195	Participates in both transcription termination and antitermination
K6959_06085	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K6959_06090	COG1358	cellular component organization or biogenesis
K6959_06100	COG1550	Protein conserved in bacteria
K6959_06105	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6959_06110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6959_06115	COG0196	riboflavin kinase activity
K6959_06120	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6959_06125	COG1185	polyribonucleotide nucleotidyltransferase activity
K6959_06130	COG0726	polysaccharide deacetylase
K6959_06140	COG1873	PFAM PRC-barrel domain
K6959_06145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6959_06150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6959_06160	COG0527	aspartate kinase activity
K6959_06170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K6959_06175	COG0740	serine-type endopeptidase activity
K6959_06185	COG1674	ftsk spoiiie
K6959_06185	COG4980	gas vesicle protein
K6959_06190	COG2188	Transcriptional regulator
K6959_06195	COG1744	ABC transporter substrate-binding protein PnrA-like
K6959_06200	COG3845	ABC transporter
K6959_06205	COG4603	Belongs to the binding-protein-dependent transport system permease family
K6959_06210	COG1079	Belongs to the binding-protein-dependent transport system permease family
K6959_06215	COG0612	Peptidase, M16
K6959_06220	COG0612	Peptidase, M16
K6959_06225	COG0300	oxidoreductase activity
K6959_06240	COG1426	Protein conserved in bacteria
K6959_06245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6959_06250	COG1058	Belongs to the CinA family
K6959_06250	COG1546	Belongs to the CinA family
K6959_06280	COG1692	metallophosphoesterase
K6959_06285	COG2359	stage V sporulation protein S
K6959_06295	COG0674	pyruvate-flavodoxin oxidoreductase activity
K6959_06295	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K6959_06300	COG1013	pyruvate-flavodoxin oxidoreductase activity
K6959_06310	COG0156	8-amino-7-oxononanoate synthase activity
K6959_06320	COG4550	Control of competence regulator ComK, YlbF/YmcA
K6959_06330	COG0583	DNA-binding transcription factor activity
K6959_06335	COG0372	Belongs to the citrate synthase family
K6959_06340	COG2318	DinB family
K6959_06350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6959_06355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6959_06360	COG1077	Cell shape determining protein MreB Mrl
K6959_06375	COG0464	growth
K6959_06380	COG2210	Belongs to the sulfur carrier protein TusA family
K6959_06390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6959_06400	COG0174	glutamine synthetase
K6959_06415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6959_06420	COG2022	thiamine diphosphate biosynthetic process
K6959_06430	COG0352	thiamine-phosphate diphosphorylase activity
K6959_06450	COG0765	amino acid transport
K6959_06455	COG0765	amino acid transport
K6959_06460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6959_06465	COG1126	abc transporter atp-binding protein
K6959_06470	COG1960	acyl-CoA dehydrogenase activity
K6959_06485	COG4647	ligase activity
K6959_06490	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
K6959_06495	COG0145	ligase activity
K6959_06525	COG1518	maintenance of DNA repeat elements
K6959_06530	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K6959_06535	COG3328	transposase activity
K6959_06540	COG2135	peptidase activity
K6959_06545	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6959_06555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K6959_06575	COG3763	UPF0154 protein
K6959_06580	COG1132	(ABC) transporter
K6959_06585	COG1132	(ABC) transporter
K6959_06595	COG0785	Cytochrome C biogenesis protein
K6959_06650	COG5444	nuclease activity
K6959_06705	COG0789	Transcriptional regulator
K6959_06710	COG5504	Zn-dependent protease
K6959_06720	COG0420	3'-5' exonuclease activity
K6959_06725	COG0419	ATPase involved in DNA repair
K6959_06775	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
K6959_06785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6959_06795	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6959_06815	COG0697	spore germination
K6959_06820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6959_06830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K6959_06860	COG1472	Belongs to the glycosyl hydrolase 3 family
K6959_06885	COG1363	Peptidase, m42
K6959_06890	COG1476	TRANSCRIPTIONal
K6959_06900	COG0405	Gamma-glutamyltransferase
K6959_06910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K6959_06925	COG1115	amino acid carrier protein
K6959_06930	COG2358	TRAP transporter, solute receptor (TAXI family
K6959_06945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K6959_06955	COG2211	Major facilitator Superfamily
K6959_06970	COG1794	racemase activity, acting on amino acids and derivatives
K6959_07000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K6959_07010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6959_07035	COG0824	Thioesterase
K6959_07045	COG2843	Capsule synthesis protein
K6959_07055	COG5002	protein histidine kinase activity
K6959_07060	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K6959_07075	COG3858	chitin binding
K6959_07080	COG1832	CoA-binding protein
K6959_07085	COG0187	DNA topoisomerase II activity
K6959_07090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6959_07145	COG4149	molybdate abc transporter
K6959_07150	COG0725	ABC transporter, periplasmic molybdate-binding protein
K6959_07155	COG1012	belongs to the aldehyde dehydrogenase family
K6959_07165	COG1380	Effector of murein hydrolase LrgA
K6959_07170	COG1346	cytolysis
K6959_07180	COG0726	polysaccharide deacetylase
K6959_07200	COG0436	Aminotransferase
K6959_07210	COG0772	Belongs to the SEDS family
K6959_07215	COG1607	acyl-coa hydrolase
K6959_07235	COG3949	Membrane
K6959_07240	COG4948	Mandelate Racemase Muconate Lactonizing
K6959_07250	COG1473	amidohydrolase
K6959_07255	COG1737	Transcriptional regulator
K6959_07265	COG1028	Short-chain dehydrogenase reductase Sdr
K6959_07280	COG2045	Belongs to the ComB family
K6959_07285	COG0318	PFAM AMP-dependent synthetase and ligase
K6959_07295	COG2234	aminopeptidase activity
K6959_07310	COG0243	molybdopterin cofactor binding
K6959_07315	COG3383	formate dehydrogenase (NAD+) activity
K6959_07350	COG1131	(ABC) transporter
K6959_07355	COG2197	response regulator
K6959_07360	COG4585	Histidine kinase
K6959_07365	COG0733	neurotransmitter:sodium symporter activity
K6959_07370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6959_07375	COG3162	membrane
K6959_07380	COG1509	lysine 2,3-aminomutase activity
K6959_07390	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K6959_07405	COG0351	phosphomethylpyrimidine kinase
K6959_07410	COG3850	Histidine kinase
K6959_07410	COG5002	protein histidine kinase activity
K6959_07415	COG0745	RESPONSE REGULATOR receiver
K6959_07435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K6959_07455	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K6959_07465	COG1116	anion transmembrane transporter activity
K6959_07480	COG2002	toxin-antitoxin pair type II binding
K6959_07505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6959_07505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6959_07515	COG0450	alkyl hydroperoxide reductase
K6959_07525	COG1846	Transcriptional regulator
K6959_07545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6959_07575	COG4974	Belongs to the 'phage' integrase family
K6959_07585	COG1028	Short-chain dehydrogenase reductase Sdr
K6959_07600	COG0583	DNA-binding transcription factor activity
K6959_07620	COG0371	Dehydrogenase
K6959_07635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6959_07655	COG1960	acyl-CoA dehydrogenase activity
K6959_07780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6959_07780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6959_07785	COG0307	riboflavin synthase, alpha
K6959_07790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6959_07790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6959_07795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K6959_07815	COG1279	arginine transmembrane transporter activity
K6959_07820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6959_07825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6959_07835	COG1793	dna ligase
K6959_07840	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K6959_07845	COG0671	phosphoesterase, PA-phosphatase related
K6959_07850	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K6959_07855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6959_07860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K6959_07875	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K6959_07895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6959_07905	COG0351	phosphomethylpyrimidine kinase
K6959_07910	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K6959_07915	COG0352	thiamine-phosphate diphosphorylase activity
K6959_07925	COG2755	lipolytic protein G-D-S-L family
K6959_07935	COG1309	transcriptional regulator
K6959_07940	COG0523	cobalamin synthesis protein
K6959_07945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6959_07950	COG0523	cobalamin synthesis protein
K6959_07955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6959_07965	COG0519	Catalyzes the synthesis of GMP from XMP
K6959_07975	COG0745	RESPONSE REGULATOR receiver
K6959_07980	COG2205	protein histidine kinase activity
K6959_07995	COG3290	protein histidine kinase activity
K6959_07995	COG3829	transcription factor binding
K6959_08005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K6959_08010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K6959_08015	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6959_08020	COG1960	acyl-CoA dehydrogenase activity
K6959_08025	COG0183	Belongs to the thiolase family
K6959_08065	COG1024	Enoyl-CoA hydratase
K6959_08070	COG0183	Belongs to the thiolase family
K6959_08075	COG1960	acyl-CoA dehydrogenase activity
K6959_08080	COG2508	Transcriptional regulator
K6959_08085	COG0318	PFAM AMP-dependent synthetase and ligase
K6959_08090	COG1131	(ABC) transporter
K6959_08120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6959_08125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6959_08130	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K6959_08135	COG1131	(ABC) transporter
K6959_08165	COG0574	Belongs to the PEP-utilizing enzyme family
K6959_08165	COG3848	Pyruvate phosphate dikinase
K6959_08170	COG3848	Pyruvate phosphate dikinase
K6959_08170	COG0574	Belongs to the PEP-utilizing enzyme family
K6959_08175	COG0574	Belongs to the PEP-utilizing enzyme family
K6959_08175	COG3848	Pyruvate phosphate dikinase
K6959_08195	COG3842	ATPase activity
K6959_08215	COG1533	DNA photolyase activity
K6959_08225	COG1131	(ABC) transporter
K6959_08235	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K6959_08240	COG2814	Major facilitator Superfamily
K6959_08290	COG1331	Highly conserved protein containing a thioredoxin domain
K6959_08295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6959_08300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6959_08305	COG0596	Alpha beta hydrolase
K6959_08310	COG2814	Major facilitator Superfamily
K6959_08345	COG2059	Chromate
K6959_08350	COG4637	Psort location Cytoplasmic, score
K6959_08355	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
K6959_08360	COG0567	Dehydrogenase, E1 component
K6959_08365	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6959_08375	COG0492	ferredoxin-NADP+ reductase activity
K6959_08390	COG0318	PFAM AMP-dependent synthetase and ligase
K6959_08395	COG1649	PFAM Uncharacterised BCR, COG1649
K6959_08405	COG0469	pyruvate kinase activity
K6959_08420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K6959_08440	COG0437	4 iron, 4 sulfur cluster binding
K6959_08455	COG2207	Transcriptional regulator
K6959_08455	COG1609	Transcriptional regulator
K6959_08465	COG1228	amidohydrolase
K6959_08470	COG0010	Belongs to the arginase family
K6959_08490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6959_08490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6959_08505	COG0488	(ABC) transporter
K6959_08525	COG3290	protein histidine kinase activity
K6959_08525	COG3829	transcription factor binding
K6959_08530	COG1012	belongs to the aldehyde dehydrogenase family
K6959_08535	COG0506	proline dehydrogenase activity
K6959_08540	COG1215	transferase activity, transferring glycosyl groups
K6959_08545	COG0726	polysaccharide deacetylase
K6959_08555	COG3858	chitin binding
K6959_08560	COG0456	acetyltransferase
K6959_08565	COG1473	amidohydrolase
K6959_08580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6959_08585	COG2011	ABC-type metal ion transport system permease component
K6959_08590	COG1464	Belongs to the NlpA lipoprotein family
K6959_08610	COG5583	Uncharacterized small protein (DUF2292)
K6959_08620	COG3832	glyoxalase III activity
K6959_08660	COG1408	metallophosphoesterase
K6959_08670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K6959_08685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6959_08695	COG1090	epimerase
K6959_08710	COG1012	belongs to the aldehyde dehydrogenase family
K6959_08715	COG0183	Belongs to the thiolase family
K6959_08720	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6959_08725	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6959_08755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6959_08770	COG1024	Enoyl-CoA hydratase
K6959_08845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6959_08860	COG1116	anion transmembrane transporter activity
K6959_08865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6959_08875	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K6959_08880	COG1131	(ABC) transporter
K6959_08895	COG0586	Pfam SNARE associated Golgi protein
K6959_08925	COG1234	tRNA 3'-trailer cleavage
K6959_08930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6959_08945	COG0534	Mate efflux family protein
K6959_08950	COG1028	Short-chain dehydrogenase reductase Sdr
K6959_08980	COG2340	Cysteine-rich secretory protein family
K6959_08990	COG5002	protein histidine kinase activity
K6959_08995	COG0745	RESPONSE REGULATOR receiver
K6959_09005	COG4257	antibiotic catabolic process
K6959_09010	COG0488	(ABC) transporter
K6959_09015	COG0425	Belongs to the sulfur carrier protein TusA family
K6959_09020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6959_09020	COG0425	Belongs to the sulfur carrier protein TusA family
K6959_09025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6959_09030	COG0425	Belongs to the sulfur carrier protein TusA family
K6959_09030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6959_09035	COG2210	Belongs to the sulfur carrier protein TusA family
K6959_09040	COG1937	Protein conserved in bacteria
K6959_09050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6959_09065	COG0523	cobalamin synthesis protein
K6959_09075	COG3409	Peptidoglycan-binding domain 1 protein
K6959_09075	COG0793	Belongs to the peptidase S41A family
K6959_09090	COG1937	Protein conserved in bacteria
K6959_09095	COG1876	peptidase activity
K6959_09110	COG2824	Alkylphosphonate utilization operon protein PhnA
K6959_09115	COG4479	Belongs to the UPF0346 family
K6959_09130	COG1509	lysine 2,3-aminomutase activity
K6959_09135	COG3829	transcription factor binding
K6959_09145	COG1012	belongs to the aldehyde dehydrogenase family
K6959_09150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6959_09155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K6959_09160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K6959_09165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6959_09180	COG1619	proteins homologs of microcin C7 resistance protein MccF
K6959_09195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6959_09205	COG2755	lipolytic protein G-D-S-L family
K6959_09210	COG1999	signal sequence binding
K6959_09215	COG1307	EDD domain protein, DegV family
K6959_09220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6959_09225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K6959_09230	COG1272	protein, Hemolysin III
K6959_09235	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K6959_09240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6959_09250	COG2310	stress, protein
K6959_09255	COG2310	stress, protein
K6959_09260	COG3853	Toxic anion resistance protein (TelA)
K6959_09290	COG0861	Integral membrane protein TerC family
K6959_09295	COG2310	stress, protein
K6959_09310	COG1413	lyase activity
K6959_09315	COG0488	(ABC) transporter
K6959_09340	COG0456	acetyltransferase
K6959_09345	COG0386	Belongs to the glutathione peroxidase family
K6959_09360	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K6959_09365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6959_09375	COG1321	iron dependent repressor
K6959_09395	COG0346	lactoylglutathione lyase activity
K6959_09430	COG3220	belongs to the UPF0276 family
K6959_09440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6959_09455	COG0653	protein targeting
K6959_09460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6959_09460	COG0551	DNA topoisomerase type I activity
K6959_09470	COG0500	methyltransferase
K6959_09485	COG0531	amino acid
K6959_09495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6959_09505	COG1960	acyl-CoA dehydrogenase activity
K6959_09520	COG1114	Component of the transport system for branched-chain amino acids
K6959_09530	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K6959_09535	COG0328	RNA-DNA hybrid ribonuclease activity
K6959_09555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6959_09570	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K6959_09575	COG1755	Isoprenylcysteine carboxyl methyltransferase
K6959_09580	COG3424	synthase
K6959_09585	COG2233	PERMEase
K6959_09600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6959_09605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6959_09615	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K6959_09625	COG5002	protein histidine kinase activity
K6959_09635	COG0745	RESPONSE REGULATOR receiver
K6959_09640	COG1199	ATP-dependent helicase activity
K6959_09650	COG0116	Belongs to the methyltransferase superfamily
K6959_09665	COG4474	Belongs to the UPF0398 family
K6959_09700	COG3331	DNA recombination
K6959_09705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6959_09705	COG4499	WXG100 protein secretion system (Wss), protein YukC
K6959_09720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6959_09725	COG3935	DnaD domain protein
K6959_09730	COG0017	Asparaginyl-tRNA synthetase
K6959_09735	COG0436	Aminotransferase
K6959_09760	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K6959_09765	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K6959_09785	COG0438	transferase activity, transferring glycosyl groups
K6959_09790	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K6959_09795	COG1803	Methylglyoxal synthase
K6959_09800	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K6959_09805	COG1694	Mazg nucleotide pyrophosphohydrolase
K6959_09810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6959_09815	COG2738	Putative neutral zinc metallopeptidase
K6959_09825	COG4347	Protein of unknown function (DUF1405)
K6959_09835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K6959_09850	COG5582	Belongs to the UPF0302 family
K6959_09855	COG0457	Tetratricopeptide repeat
K6959_09865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K6959_09870	COG0287	Prephenate dehydrogenase
K6959_09875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6959_09880	COG4401	Chorismate mutase type I
K6959_09885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6959_09890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K6959_09895	COG0105	UTP biosynthetic process
K6959_09900	COG0142	geranyltranstransferase activity
K6959_09910	COG0142	geranyltranstransferase activity
K6959_09920	COG0302	gtp cyclohydrolase
K6959_09925	COG0776	regulation of translation
K6959_09930	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K6959_09950	COG1160	GTP binding
K6959_09975	COG1304	FMN binding
K6959_09980	COG0539	negative regulation of cytoplasmic translation
K6959_09985	COG0204	Acyl-transferase
K6959_09990	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6959_10010	COG2959	enzyme of heme biosynthesis
K6959_10020	COG2339	peptidase activity
K6959_10030	COG0492	ferredoxin-NADP+ reductase activity
K6959_10035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6959_10040	COG4862	establishment of competence for transformation
K6959_10055	COG3546	catalase activity
K6959_10085	COG1266	CAAX protease self-immunity
K6959_10095	COG4955	Helix-turn-helix domain
K6959_10100	COG4955	Helix-turn-helix domain
K6959_10110	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K6959_10120	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K6959_10120	COG1918	ferrous iron import across plasma membrane
K6959_10130	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K6959_10140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6959_10165	COG1595	DNA-templated transcription, initiation
K6959_10170	COG5002	protein histidine kinase activity
K6959_10175	COG0745	RESPONSE REGULATOR receiver
K6959_10180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6959_10185	COG1333	cytochrome c biogenesis protein
K6959_10195	COG1187	pseudouridine synthase activity
K6959_10200	COG0700	Nucleoside recognition
K6959_10205	COG2715	membrane protein required for spore maturation
K6959_10210	COG1686	Belongs to the peptidase S11 family
K6959_10215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K6959_10225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K6959_10230	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K6959_10260	COG0697	spore germination
K6959_10280	COG2172	sigma factor antagonist activity
K6959_10290	COG1686	Belongs to the peptidase S11 family
K6959_10310	COG4974	Belongs to the 'phage' integrase family
K6959_10320	COG0735	belongs to the Fur family
K6959_10325	COG1300	Membrane
K6959_10330	COG1379	DNA repair
K6959_10340	COG0667	Aldo Keto reductase
K6959_10400	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K6959_10405	COG0183	Belongs to the thiolase family
K6959_10410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6959_10415	COG1073	alpha beta
K6959_10420	COG4918	Iron-sulphur cluster biosynthesis
K6959_10435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K6959_10440	COG0300	oxidoreductase activity
K6959_10445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6959_10450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6959_10455	COG1215	transferase activity, transferring glycosyl groups
K6959_10470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K6959_10480	COG0477	Major facilitator Superfamily
K6959_10485	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6959_10490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6959_10495	COG0346	lactoylglutathione lyase activity
K6959_10505	COG1376	ErfK ybiS ycfS ynhG family protein
K6959_10510	COG1126	abc transporter atp-binding protein
K6959_10515	COG0765	amino acid transport
K6959_10520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6959_10530	COG1703	isobutyryl-CoA mutase activity
K6959_10535	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6959_10535	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6959_10540	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6959_10555	COG2801	Transposase and inactivated derivatives
K6959_10560	COG2801	Transposase and inactivated derivatives
K6959_10570	COG2963	transposase activity
K6959_10605	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6959_10615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K6959_10625	COG3426	butyrate kinase activity
K6959_10635	COG0280	phosphate acetyltransferase
K6959_10640	COG3290	protein histidine kinase activity
K6959_10640	COG3829	transcription factor binding
K6959_10650	COG0584	glycerophosphoryl diester phosphodiesterase
K6959_10670	COG0497	DNA recombination
K6959_10675	COG1438	arginine binding
K6959_10685	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K6959_10700	COG1722	exodeoxyribonuclease VII activity
K6959_10705	COG1570	exodeoxyribonuclease VII activity
K6959_10710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6959_10715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6959_10720	COG1302	Protein conserved in bacteria
K6959_10725	COG0439	Biotin carboxylase
K6959_10730	COG0511	ligase activity, forming carbon-carbon bonds
K6959_10770	COG3854	ATPases associated with a variety of cellular activities
K6959_10775	COG0492	ferredoxin-NADP+ reductase activity
K6959_10780	COG1785	Belongs to the alkaline phosphatase family
K6959_10785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K6959_10790	COG0006	proline dipeptidase activity
K6959_10795	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K6959_10805	COG3872	metal-dependent enzyme
K6959_10815	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6959_10820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6959_10825	COG0095	Lipoate-protein ligase
K6959_10830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6959_10835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6959_10845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6959_10850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6959_10890	COG4537	Required for transformation and DNA binding
K6959_10895	COG1459	type II secretion system
K6959_10900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6959_10925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6959_10960	COG1368	sulfuric ester hydrolase activity
K6959_10970	COG0697	spore germination
K6959_10980	COG0457	Tetratricopeptide repeat
K6959_10980	COG0705	Rhomboid family
K6959_10995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6959_11000	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6959_11010	COG0704	Plays a role in the regulation of phosphate uptake
K6959_11015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6959_11020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6959_11030	COG0573	inorganic phosphate transmembrane transporter activity
K6959_11035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K6959_11040	COG0768	penicillin binding
K6959_11045	COG0477	Major facilitator Superfamily
K6959_11055	COG2839	Protein conserved in bacteria
K6959_11060	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6959_11065	COG5521	maltodextrose utilization protein MalA
K6959_11070	COG2814	Major facilitator Superfamily
K6959_11085	COG4709	membrane
K6959_11090	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
K6959_11100	COG0735	belongs to the Fur family
K6959_11105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6959_11110	COG1121	(ABC) transporter
K6959_11120	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6959_11125	COG0513	Belongs to the DEAD box helicase family
K6959_11140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6959_11145	COG2384	SAM-dependent methyltransferase
K6959_11150	COG2010	Cytochrome c
K6959_11155	COG1960	acyl-CoA dehydrogenase activity
K6959_11160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6959_11165	COG0358	DNA primase activity
K6959_11170	COG1671	Belongs to the UPF0178 family
K6959_11180	COG0517	IMP dehydrogenase activity
K6959_11195	COG1381	Involved in DNA repair and RecF pathway recombination
K6959_11205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6959_11215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6959_11225	COG1480	7TM receptor with intracellular HD hydrolase
K6959_11230	COG1702	phosphate starvation-inducible protein PhoH
K6959_11250	COG4864	UPF0365 protein
K6959_11255	COG1030	water channel activity
K6959_11260	COG1610	YqeY-like protein
K6959_11270	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6959_11275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6959_11280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6959_11285	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K6959_11290	COG2264	protein methyltransferase activity
K6959_11300	COG0443	Heat shock 70 kDa protein
K6959_11305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6959_11310	COG1420	regulation of RNA biosynthetic process
K6959_11315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6959_11330	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6959_11345	COG1466	dna polymerase III delta subunit
K6959_11355	COG0658	competence protein
K6959_11355	COG2333	competence protein COMEC
K6959_11360	COG2131	deaminase
K6959_11365	COG1596	polysaccharide export
K6959_11365	COG1555	photosystem II stabilization
K6959_11370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6959_11375	COG2226	methyltransferase
K6959_11380	COG0799	negative regulation of ribosome biogenesis
K6959_11385	COG1713	HD superfamily hydrolase involved in NAD metabolism
K6959_11390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6959_11395	COG1534	Rna-binding protein
K6959_11410	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K6959_11420	COG0688	phosphatidylethanolamine metabolic process
K6959_11425	COG1183	phosphatidylcholine synthase activity
K6959_11490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6959_11505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6959_11510	COG0572	uridine kinase
K6959_11515	COG0826	peptidase U32
K6959_11520	COG0826	peptidase U32
K6959_11540	COG3906	Belongs to the UPF0473 family
K6959_11545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6959_11550	COG4472	Bacterial protein of unknown function (DUF965)
K6959_11555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6959_11560	COG0628	permease
K6959_11615	COG0456	acetyltransferase
K6959_11615	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K6959_11635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6959_11650	COG1104	cysteine desulfurase activity
K6959_11655	COG1959	2 iron, 2 sulfur cluster binding
K6959_11660	COG2364	Membrane
K6959_11665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6959_11670	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K6959_11675	COG1131	(ABC) transporter
K6959_11685	COG1725	Transcriptional regulator
K6959_11700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6959_11710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K6959_11715	COG0124	histidyl-tRNA synthetase
K6959_11725	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6959_11725	COG3103	Sh3 type 3 domain protein
K6959_11725	COG4991	sh3 domain protein
K6959_11740	COG3842	ATPase activity
K6959_11745	COG1178	ABC-type Fe3 transport system permease component
K6959_11750	COG1840	ABC-type Fe3 transport system, periplasmic component
K6959_11755	COG1490	D-aminoacyl-tRNA deacylase activity
K6959_11760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6959_11795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6959_11800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6959_11800	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K6959_11810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6959_11810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6959_11820	COG2244	polysaccharide biosynthetic process
K6959_11825	COG2323	membrane
K6959_11835	COG1862	Preprotein translocase
K6959_11840	COG0343	queuine tRNA-ribosyltransferase activity
K6959_11845	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6959_11870	COG0217	transcriptional regulatory protein
K6959_11880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K6959_11890	COG1388	LysM domain
K6959_11900	COG0157	Belongs to the NadC ModD family
K6959_11905	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K6959_11910	COG1104	cysteine desulfurase activity
K6959_11915	COG1827	regulation of RNA biosynthetic process
K6959_11920	COG0077	Prephenate dehydratase
K6959_11925	COG4492	Belongs to the UPF0735 family
K6959_11930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6959_11935	COG3290	protein histidine kinase activity
K6959_11940	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K6959_11945	COG2868	ribosomal protein
K6959_11950	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6959_11960	COG1994	Peptidase M50
K6959_11965	COG0739	heme binding
K6959_11985	COG2894	cell division
K6959_11990	COG0850	regulation of cytokinetic process
K6959_12000	COG1792	Involved in formation and maintenance of cell shape
K6959_12005	COG1077	Cell shape determining protein MreB Mrl
K6959_12035	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K6959_12045	COG0285	dihydrofolate synthase activity
K6959_12060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6959_12065	COG1388	LysM domain
K6959_12065	COG1388	LysM domain
K6959_12070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K6959_12075	COG0113	porphobilinogen synthase activity
K6959_12090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6959_12105	COG1126	abc transporter atp-binding protein
K6959_12110	COG0765	amino acid transport
K6959_12115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6959_12120	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K6959_12125	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6959_12130	COG0470	DNA polymerase III
K6959_12130	COG1067	ATP-dependent peptidase activity
K6959_12140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6959_12145	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6959_12155	COG0066	3-isopropylmalate dehydratase activity
K6959_12160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K6959_12170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6959_12175	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6959_12180	COG0440	acetolactate synthase activity
K6959_12185	COG0028	Belongs to the TPP enzyme family
K6959_12190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6959_12200	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K6959_12215	COG0622	Phosphoesterase
K6959_12220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K6959_12230	COG5401	PFAM Sporulation and spore germination
K6959_12240	COG1846	Transcriptional regulator
K6959_12245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6959_12255	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6959_12275	COG3336	cytochrome c oxidase
K6959_12280	COG0196	riboflavin kinase activity
K6959_12285	COG2814	Major facilitator Superfamily
K6959_12305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6959_12335	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6959_12365	COG0183	Belongs to the thiolase family
K6959_12370	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6959_12375	COG1012	belongs to the aldehyde dehydrogenase family
K6959_12380	COG1024	Enoyl-CoA hydratase
K6959_12395	COG2151	metal-sulfur cluster biosynthetic enzyme
K6959_12410	COG3396	Phenylacetate-CoA oxygenase
K6959_12415	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K6959_12420	COG2176	DNA-directed DNA polymerase activity
K6959_12440	COG2197	response regulator
K6959_12445	COG0824	Thioesterase
K6959_12450	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6959_12455	COG1053	succinate dehydrogenase
K6959_12460	COG2009	succinate dehydrogenase
K6959_12465	COG1719	4-vinyl reductase, 4VR
K6959_12480	COG3118	belongs to the thioredoxin family
K6959_12485	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K6959_12490	COG2086	electron transfer activity
K6959_12495	COG1024	Enoyl-CoA hydratase
K6959_12500	COG1309	transcriptional regulator
K6959_12505	COG0318	PFAM AMP-dependent synthetase and ligase
K6959_12515	COG1193	negative regulation of DNA recombination
K6959_12520	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K6959_12520	COG1796	DNA polymerase
K6959_12525	COG1286	toxin biosynthetic process
K6959_12530	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K6959_12545	COG0072	phenylalanine-tRNA ligase activity
K6959_12545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6959_12550	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6959_12555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6959_12565	COG1363	Peptidase, m42
K6959_12580	COG0398	Pfam SNARE associated Golgi protein
K6959_12620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K6959_12625	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6959_12635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6959_12645	COG1484	DNA-dependent DNA replication
K6959_12650	COG3611	Membrane attachment protein
K6959_12655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K6959_12660	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K6959_12665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6959_12670	COG0237	dephospho-CoA kinase activity
K6959_12675	COG1971	Probably functions as a manganese efflux pump
K6959_12680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K6959_12685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6959_12685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6959_12690	COG0330	HflC and HflK could
K6959_12695	COG0330	HflC and HflK could
K6959_12705	COG0745	RESPONSE REGULATOR receiver
K6959_12715	COG0039	L-malate dehydrogenase activity
K6959_12720	COG0538	isocitrate dehydrogenase activity
K6959_12725	COG0372	Belongs to the citrate synthase family
K6959_12730	COG2707	UPF0756 membrane protein
K6959_12735	COG0628	permease
K6959_12740	COG3030	protein affecting phage T7 exclusion by the F plasmid
K6959_12760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6959_12765	COG1725	Transcriptional regulator
K6959_12770	COG0281	malic enzyme
K6959_12775	COG0587	DNA-directed DNA polymerase activity
K6959_12790	COG2205	protein histidine kinase activity
K6959_12805	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6959_12815	COG4109	DRTGG domain
K6959_12825	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K6959_12830	COG0006	proline dipeptidase activity
K6959_12845	COG0589	response to stress
K6959_12855	COG0165	Argininosuccinate lyase
K6959_12860	COG0137	argininosuccinate synthase activity
K6959_12885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6959_12890	COG0827	DNA restriction-modification system
K6959_12895	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K6959_12900	COG3874	Sporulation protein YtfJ
K6959_12910	COG1714	RDD family
K6959_12915	COG0616	signal peptide processing
K6959_12925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6959_12940	COG0301	tRNA thio-modification
K6959_12945	COG1104	cysteine desulfurase activity
K6959_12950	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K6959_12955	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K6959_12970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K6959_12975	COG2312	Erythromycin esterase
K6959_13000	COG0454	-acetyltransferase
K6959_13005	COG0517	IMP dehydrogenase activity
K6959_13010	COG0123	including yeast histone deacetylase and acetoin utilization protein
K6959_13025	COG3118	belongs to the thioredoxin family
K6959_13040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6959_13050	COG1674	ftsk spoiiie
K6959_13055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6959_13060	COG4848	Belongs to the UPF0354 family
K6959_13065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6959_13085	COG1363	Peptidase, m42
K6959_13090	COG5584	Small secreted protein
K6959_13095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6959_13100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K6959_13110	COG0510	thiamine kinase activity
K6959_13135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6959_13140	COG4473	ABC transporter
K6959_13145	COG1131	(ABC) transporter
K6959_13155	COG1349	DNA-binding transcription factor activity
K6959_13160	COG1187	pseudouridine synthase activity
K6959_13170	COG2244	polysaccharide biosynthetic process
K6959_13175	COG2081	HI0933 family
K6959_13215	COG1476	TRANSCRIPTIONal
K6959_13235	COG1301	dicarboxylic acid transport
K6959_13245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6959_13255	COG1476	TRANSCRIPTIONal
K6959_13260	COG0495	leucyl-tRNA aminoacylation
K6959_13270	COG1028	Short-chain dehydrogenase reductase Sdr
K6959_13275	COG2610	gluconate transmembrane transporter activity
K6959_13280	COG3290	protein histidine kinase activity
K6959_13280	COG3829	transcription factor binding
K6959_13290	COG1242	4 iron, 4 sulfur cluster binding
K6959_13295	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K6959_13310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6959_13315	COG0367	asparagine synthase
K6959_13320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6959_13325	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6959_13335	COG1506	peptidase
K6959_13350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6959_13355	COG0494	nUDIX hydrolase
K6959_13380	COG1854	S-ribosylhomocysteine lyase activity
K6959_13385	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K6959_13390	COG0288	reversible hydration of carbon dioxide
K6959_13400	COG1271	oxidase subunit
K6959_13405	COG1294	oxidase, subunit
K6959_13415	COG0318	PFAM AMP-dependent synthetase and ligase
K6959_13420	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K6959_13425	COG0596	Alpha beta hydrolase
K6959_13435	COG1169	isochorismate synthase
K6959_13445	COG1575	Belongs to the MenA family. Type 1 subfamily
K6959_13450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K6959_13615	COG1011	Hydrolase
K6959_13645	COG4175	Glycine betaine
K6959_13645	COG0517	IMP dehydrogenase activity
K6959_13650	COG4176	ABC-type proline glycine betaine transport system permease component
K6959_13665	COG0659	secondary active sulfate transmembrane transporter activity
K6959_13670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6959_13680	COG2155	Conserved Protein
K6959_13685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6959_13690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6959_13695	COG1757	Na H antiporter
K6959_13700	COG1098	S1 RNA binding domain
K6959_13710	COG2267	carboxylic ester hydrolase activity
K6959_13715	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K6959_13720	COG2032	superoxide dismutase activity
K6959_13755	COG2111	Na H antiporter
K6959_13760	COG1006	Multisubunit Na H antiporter MnhC subunit
K6959_13765	COG0651	ATP synthesis coupled electron transport
K6959_13770	COG1863	multisubunit Na H antiporter MnhE subunit
K6959_13775	COG2212	antiporter activity
K6959_13780	COG1320	monovalent cation:proton antiporter activity
K6959_13785	COG2050	protein possibly involved in aromatic compounds catabolism
K6959_13800	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6959_13815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K6959_13825	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K6959_13835	COG3584	3D domain protein
K6959_13850	COG1252	NADH dehydrogenase
K6959_13860	COG0316	Belongs to the HesB IscA family
K6959_13865	COG4844	belongs to the
K6959_13870	COG1252	NADH dehydrogenase
K6959_13880	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K6959_13885	COG0083	homoserine kinase activity
K6959_13890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K6959_13895	COG0460	homoserine dehydrogenase
K6959_13900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6959_13905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6959_13910	COG0647	UMP catabolic process
K6959_13915	COG2445	Protein of unknown function DUF86
K6959_13930	COG4470	Protein conserved in bacteria
K6959_13950	COG0733	neurotransmitter:sodium symporter activity
K6959_13955	COG1757	Na H antiporter
K6959_13965	COG3377	Domain of unknown function (DUF1805)
K6959_13985	COG1309	transcriptional regulator
K6959_13990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6959_14010	COG1129	ABC transporter
K6959_14025	COG1595	DNA-templated transcription, initiation
K6959_14040	COG0719	Fe-S assembly protein
K6959_14045	COG0822	iron-sulfur transferase activity
K6959_14050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6959_14055	COG0719	Fe-S assembly protein
K6959_14060	COG0396	ATPase activity
K6959_14065	COG0204	Acyl-transferase
K6959_14080	COG1216	Glycosyl transferase, family 2
K6959_14090	COG1215	transferase activity, transferring glycosyl groups
K6959_14095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6959_14100	COG1464	Belongs to the NlpA lipoprotein family
K6959_14105	COG2011	ABC-type metal ion transport system permease component
K6959_14110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6959_14115	COG2873	o-acetylhomoserine
K6959_14130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6959_14135	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K6959_14140	COG0509	glycine decarboxylation via glycine cleavage system
K6959_14145	COG1393	Belongs to the ArsC family
K6959_14150	COG1960	acyl-CoA dehydrogenase activity
K6959_14155	COG0183	Belongs to the thiolase family
K6959_14160	COG1024	Enoyl-CoA hydratase
K6959_14160	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6959_14165	COG0506	proline dehydrogenase activity
K6959_14175	COG5577	PFAM Coat F domain
K6959_14185	COG0772	Belongs to the SEDS family
K6959_14225	COG3011	Protein conserved in bacteria
K6959_14230	COG2258	MOSC domain
K6959_14235	COG1690	Belongs to the RtcB family
K6959_14275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6959_14280	COG1012	belongs to the aldehyde dehydrogenase family
K6959_14295	COG1309	transcriptional regulator
K6959_14315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K6959_14320	COG0022	dehydrogenase e1 component
K6959_14360	COG1511	domain protein
K6959_14365	COG0433	COG0433 Predicted ATPase
K6959_14365	COG1674	ftsk spoiiie
K6959_14370	COG4499	WXG100 protein secretion system (Wss), protein YukC
K6959_14375	COG5417	Belongs to the EsaB family
K6959_14380	COG4842	Belongs to the WXG100 family
K6959_14410	COG5444	nuclease activity
K6959_14425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6959_14430	COG0557	exoribonuclease II activity
K6959_14435	COG1647	Serine aminopeptidase, S33
K6959_14440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6959_14445	COG0148	phosphopyruvate hydratase activity
K6959_14450	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K6959_14460	COG0126	phosphoglycerate kinase activity
K6959_14480	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K6959_14495	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K6959_14515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6959_14525	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K6959_14530	COG1660	Displays ATPase and GTPase activities
K6959_14535	COG1051	belongs to the nudix hydrolase family
K6959_14540	COG0492	ferredoxin-NADP+ reductase activity
K6959_14545	COG0457	Tetratricopeptide repeat
K6959_14550	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6959_14550	COG0140	phosphoribosyl-ATP diphosphatase activity
K6959_14555	COG0107	imidazoleglycerol-phosphate synthase activity
K6959_14560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6959_14565	COG0131	Imidazoleglycerol-phosphate dehydratase
K6959_14570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6959_14575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K6959_14590	COG0110	maltose O-acetyltransferase activity
K6959_14595	COG0546	phosphoglycolate phosphatase activity
K6959_14600	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K6959_14605	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6959_14610	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K6959_14615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6959_14620	COG0363	glucosamine-6-phosphate deaminase activity
K6959_14625	COG2188	Transcriptional regulator
K6959_14630	COG1950	PFAM Membrane protein of
K6959_14635	COG3595	metallopeptidase activity
K6959_14645	COG0556	nucleotide-excision repair
K6959_14650	COG4897	Protein conserved in bacteria
K6959_14660	COG3263	regulation of cellular component size
K6959_14670	COG4844	belongs to the
K6959_14685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6959_14690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6959_14695	COG0793	Belongs to the peptidase S41A family
K6959_14695	COG3409	Peptidoglycan-binding domain 1 protein
K6959_14700	COG3384	dioxygenase
K6959_14705	COG3883	PFAM NLP P60 protein
K6959_14705	COG0791	NLP P60 protein
K6959_14710	COG2177	Part of the ABC transporter FtsEX involved in
K6959_14715	COG2884	Cell division ATP-binding protein ftsE
K6959_14725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6959_14735	COG0653	protein targeting
K6959_14745	COG1040	competence protein
K6959_14750	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K6959_14760	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K6959_14765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6959_14770	COG1696	Membrane protein involved in D-alanine export
K6959_14780	COG2197	response regulator
K6959_14790	COG1739	Uncharacterized protein family UPF0029
K6959_14795	COG1316	TRANSCRIPTIONal
K6959_14825	COG4193	domain, Protein
K6959_14840	COG0438	transferase activity, transferring glycosyl groups
K6959_14850	COG3307	-O-antigen
K6959_14870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6959_14875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6959_14885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K6959_14900	COG0768	penicillin binding
K6959_14940	COG0596	Alpha beta hydrolase
K6959_14965	COG2814	Major facilitator Superfamily
K6959_14990	COG4715	Zinc finger, swim domain protein
K6959_14995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6959_15005	COG0629	single-stranded DNA binding
K6959_15035	COG1609	Transcriptional regulator
K6959_15040	COG0791	NLP P60 protein
K6959_15040	COG1388	LysM domain
K6959_15050	COG0739	heme binding
K6959_15060	COG2385	sporulation resulting in formation of a cellular spore
K6959_15065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6959_15075	COG4836	Membrane
K6959_15080	COG1007	ATP synthesis coupled electron transport
K6959_15085	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6959_15090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6959_15095	COG0713	ATP synthesis coupled electron transport
K6959_15100	COG0839	Belongs to the complex I subunit 6 family
K6959_15110	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K6959_15115	COG0649	NAD binding
K6959_15120	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6959_15125	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6959_15130	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6959_15135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6959_15135	COG0512	Glutamine amidotransferase of anthranilate synthase
K6959_15140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K6959_15145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6959_15150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6959_15155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6959_15160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6959_15165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6959_15170	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6959_15175	COG0356	it plays a direct role in the translocation of protons across the membrane
K6959_15185	COG1404	Belongs to the peptidase S8 family
K6959_15190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K6959_15195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6959_15200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6959_15215	COG0698	ribose 5-phosphate isomerase
K6959_15225	COG1971	Probably functions as a manganese efflux pump
K6959_15230	COG0009	L-threonylcarbamoyladenylate synthase
K6959_15250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K6959_15265	COG1435	thymidine kinase activity
K6959_15270	COG0254	rRNA binding
K6959_15275	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K6959_15280	COG1494	fructose-1,6-bisphosphatase
K6959_15285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6959_15290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6959_15295	COG0191	fructose-bisphosphate aldolase activity
K6959_15300	COG2204	response regulator
K6959_15305	COG4821	SIS domain
K6959_15310	COG0504	CTP synthase activity
K6959_15325	COG1703	isobutyryl-CoA mutase activity
K6959_15325	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6959_15325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6959_15335	COG1960	acyl-CoA dehydrogenase activity
K6959_15340	COG1960	acyl-CoA dehydrogenase activity
K6959_15345	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6959_15350	COG0183	Belongs to the thiolase family
K6959_15355	COG0247	lactate metabolic process
K6959_15355	COG2181	nitrate reductase activity
K6959_15360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6959_15370	COG0018	arginyl-trna synthetase
K6959_15380	COG0010	Belongs to the arginase family
K6959_15385	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K6959_15405	COG1994	Peptidase M50
K6959_15415	COG3465	dGTPase activity
K6959_15420	COG1078	dGTPase activity
K6959_15425	COG4844	belongs to the
K6959_15440	COG0280	phosphate acetyltransferase
K6959_15445	COG3253	May function as heme-dependent peroxidase
K6959_15450	COG3773	Cell wall hydrolase
K6959_15460	COG2363	Small membrane protein
K6959_15475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6959_15480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6959_15485	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K6959_15490	COG0314	molybdopterin synthase activity
K6959_15495	COG0746	molybdenum cofactor guanylyltransferase activity
K6959_15515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K6959_15530	COG0561	phosphatase activity
K6959_15535	COG1595	DNA-templated transcription, initiation
K6959_15540	COG2031	fatty acid transporter
K6959_15545	COG2059	Chromate
K6959_15550	COG2059	Chromate
K6959_15560	COG1132	(ABC) transporter
K6959_15565	COG0583	DNA-binding transcription factor activity
K6959_15570	COG2855	membrane
K6959_15580	COG3279	Response regulator of the LytR AlgR family
K6959_15585	COG0427	acetyl-CoA hydrolase
K6959_15590	COG4608	Belongs to the ABC transporter superfamily
K6959_15595	COG0444	Belongs to the ABC transporter superfamily
K6959_15600	COG0601	transmembrane transport
K6959_15610	COG0747	negative chemotaxis
K6959_15615	COG0584	glycerophosphoryl diester phosphodiesterase
K6959_15635	COG3842	ATPase activity
K6959_15640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6959_15645	COG3290	protein histidine kinase activity
K6959_15650	COG1309	transcriptional regulator
K6959_15655	COG2076	Multidrug Resistance protein
K6959_15660	COG2076	Multidrug Resistance protein
K6959_15665	COG0384	phenazine biosynthesis protein PhzF
K6959_15680	COG0577	efflux transmembrane transporter activity
K6959_15685	COG1136	(ABC) transporter
K6959_15700	COG0300	oxidoreductase activity
K6959_15720	COG4086	secreted protein
K6959_15725	COG0569	domain protein
K6959_15725	COG0475	glutathione-regulated potassium exporter activity
K6959_15730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6959_15730	COG0723	plastoquinol--plastocyanin reductase activity
K6959_15735	COG0450	alkyl hydroperoxide reductase
K6959_15760	COG1131	(ABC) transporter
K6959_15785	COG2197	response regulator
K6959_15845	COG1131	(ABC) transporter
K6959_15855	COG0745	RESPONSE REGULATOR receiver
K6959_15870	COG0583	DNA-binding transcription factor activity
K6959_15885	COG1131	(ABC) transporter
K6959_15900	COG0584	glycerophosphoryl diester phosphodiesterase
K6959_15915	COG3876	Protein conserved in bacteria
K6959_15920	COG1472	Belongs to the glycosyl hydrolase 3 family
K6959_15925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6959_15985	COG4948	Mandelate Racemase Muconate Lactonizing
K6959_16020	COG1028	Short-chain dehydrogenase reductase Sdr
K6959_16040	COG0489	protein tyrosine kinase activity
K6959_16045	COG0017	Asparaginyl-tRNA synthetase
K6959_16085	COG1131	(ABC) transporter
K6959_16095	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6959_16125	COG1061	Type III restriction enzyme res subunit
K6959_16145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6959_16150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6959_16180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6959_16185	COG0156	8-amino-7-oxononanoate synthase activity
K6959_16195	COG2124	cytochrome p450
K6959_16225	COG0579	oxidoreductase
K6959_16255	COG0450	alkyl hydroperoxide reductase
K6959_16380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6959_16385	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K6959_16390	COG4853	Protein conserved in bacteria
K6959_16400	COG5002	protein histidine kinase activity
K6959_16405	COG0745	RESPONSE REGULATOR receiver
K6959_16410	COG1196	nuclear chromosome segregation
K6959_16410	COG0739	heme binding
K6959_16410	COG0741	lytic transglycosylase activity
K6959_16445	COG0582	viral genome integration into host DNA
K6959_16465	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K6959_16515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6959_16520	COG0431	NADPH-dependent FMN reductase
K6959_16525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6959_16530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6959_16540	COG2873	o-acetylhomoserine
K6959_16555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6959_16555	COG1116	anion transmembrane transporter activity
K6959_16605	COG0305	Participates in initiation and elongation during chromosome replication
K6959_16610	COG0359	binds to the 23S rRNA
K6959_16615	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
K6959_16620	COG4241	membrane
K6959_16650	COG4974	Belongs to the 'phage' integrase family
K6959_16655	COG0629	single-stranded DNA binding
K6959_16660	COG0360	Binds together with S18 to 16S ribosomal RNA
K6959_16665	COG0012	GTP binding
K6959_16670	COG4481	Protein conserved in bacteria
K6959_16685	COG1475	DNA binding
K6959_16690	COG1192	Involved in chromosome partitioning
K6959_16695	COG1475	DNA binding
K6959_16700	COG0357	Ribosomal RNA small subunit methyltransferase G
K6959_16705	COG0445	tRNA wobble uridine modification
K6959_16710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6959_16715	COG1847	R3H domain protein
K6959_16740	COG0592	DNA-directed DNA polymerase activity
K6959_16745	COG2501	S4 domain
K6959_16750	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K6959_16760	COG0187	DNA topoisomerase II activity
K6959_16765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6959_16805	COG0517	IMP dehydrogenase activity
K6959_16805	COG0516	GMP reductase activity
K6959_16820	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
K6959_16825	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K6959_16835	COG0590	tRNA wobble adenosine to inosine editing
K6959_16845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K6959_16850	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K6959_16855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6959_16905	COG1982	Orn Lys Arg decarboxylase major
K6959_16915	COG3870	Protein conserved in bacteria
K6959_16920	COG0470	DNA polymerase III
K6959_16925	COG1774	PSP1 C-terminal conserved region
K6959_16930	COG4467	Involved in initiation control of chromosome replication
K6959_16935	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6959_16940	COG2827	Endonuclease containing a URI domain
K6959_16945	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6959_16950	COG2002	toxin-antitoxin pair type II binding
K6959_16965	COG3584	3D domain protein
K6959_16965	COG3583	domain protein
K6959_16970	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K6959_16975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6959_16985	COG4466	Protein conserved in bacteria
K6959_17000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6959_17005	COG0251	oxidation-reduction process
K6959_17015	COG2088	sporulation resulting in formation of a cellular spore
K6959_17020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K6959_17050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6959_17055	COG2002	toxin-antitoxin pair type II binding
K6959_17060	COG2244	polysaccharide biosynthetic process
K6959_17065	COG3956	TIGRFAM MazG family protein
K6959_17070	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6959_17090	COG1098	S1 RNA binding domain
K6959_17100	COG2208	phosphoserine phosphatase activity
K6959_17105	COG2304	oxidoreductase activity
K6959_17120	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K6959_17125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6959_17135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K6959_17145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6959_17165	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6959_17170	COG1396	sequence-specific DNA binding
K6959_17175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6959_17180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K6959_17260	COG2814	Major facilitator Superfamily
K6959_17270	COG3880	PFAM UvrB UvrC protein
K6959_17275	COG3869	Catalyzes the specific phosphorylation of arginine residues in
K6959_17280	COG0542	response to heat
K6959_17285	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6959_17290	COG4956	integral membrane protein (PIN domain superfamily)
K6959_17295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K6959_17300	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K6959_17310	COG1045	serine acetyltransferase
K6959_17325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6959_17330	COG3688	RNA-binding protein containing a PIN domain
K6959_17340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6959_17345	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6959_17350	COG0250	Participates in transcription elongation, termination and antitermination
K6959_17355	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K6959_17360	COG0081	regulation of translation
K6959_17365	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6959_17370	COG0222	ribosome binding
K6959_17375	COG2813	Specifically methylates the guanine in position
K6959_17385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K6959_17390	COG1358	cellular component organization or biogenesis
K6959_17400	COG0049	tRNA binding
K6959_17405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6959_17410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6959_17415	COG0051	transcription antitermination factor activity, RNA binding
K6959_17420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6959_17425	COG0088	Forms part of the polypeptide exit tunnel
K6959_17440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6959_17445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6959_17450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6959_17460	COG0255	Belongs to the universal ribosomal protein uL29 family
K6959_17465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6959_17470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K6959_17475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6959_17480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6959_17495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K6959_17500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K6959_17505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K6959_17510	COG1841	ribosomal large subunit assembly
K6959_17520	COG0201	protein transport
K6959_17525	COG0563	adenylate kinase activity
K6959_17530	COG0024	Methionine aminopeptidase
K6959_17535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6959_17540	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6959_17545	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6959_17550	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K6959_17555	COG0202	RNA polymerase activity
K6959_17560	COG0203	ribosomal protein L17
K6959_17565	COG1122	ATPase activity
K6959_17570	COG1122	ATPase activity
K6959_17575	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K6959_17580	COG0101	tRNA pseudouridine synthase activity
K6959_17585	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K6959_17590	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6959_17655	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K6959_17675	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6959_17695	COG1136	(ABC) transporter
K6959_17725	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6959_17730	COG0489	protein tyrosine kinase activity
K6959_17740	COG2194	sulfuric ester hydrolase activity
K6959_17745	COG0726	polysaccharide deacetylase
K6959_17820	COG1595	DNA-templated transcription, initiation
K6959_17825	COG5662	AntiSigma factor
K6959_17830	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K6959_17835	COG4856	YbbR-like protein
K6959_17840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6959_17870	COG1175	transmembrane transport
K6959_17875	COG0395	ABC-type sugar transport system, permease component
K6959_17925	COG1518	maintenance of DNA repeat elements
K6959_17930	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K6959_17955	COG0717	Belongs to the dCTP deaminase family
K6959_17960	COG1272	protein, Hemolysin III
K6959_17965	COG1227	inorganic diphosphatase activity
K6959_17970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6959_17975	COG4605	iron ion homeostasis
K6959_17980	COG4604	ABC transporter, ATP-binding protein
K6959_17990	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K6959_17995	COG2076	Multidrug Resistance protein
K6959_18010	COG1959	2 iron, 2 sulfur cluster binding
K6959_18020	COG1136	(ABC) transporter
K6959_18025	COG0561	phosphatase activity
K6959_18110	COG3344	reverse transcriptase
K6959_18155	COG3610	response to peptide
K6959_18160	COG2966	Psort location CytoplasmicMembrane, score
K6959_18200	COG0640	Transcriptional regulator
K6959_18205	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K6959_18210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6959_18215	COG2814	Major facilitator Superfamily
K6959_18220	COG3344	reverse transcriptase
K6959_18285	COG0003	Pfam Anion-transporting ATPase
K6959_18310	COG2226	methyltransferase
K6959_18315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6959_18320	COG0626	cystathionine gamma-synthase activity
K6959_18325	COG0514	ATP-dependent DNA helicase (RecQ)
K6959_18335	COG2318	DinB family
K6959_18345	COG3842	ATPase activity
K6959_18350	COG1176	ABC-type spermidine putrescine transport system, permease component I
K6959_18355	COG1177	transmembrane transport
K6959_18360	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K6959_18365	COG4129	membrane
K6959_18370	COG0697	spore germination
K6959_18385	COG3639	organic phosphonate transmembrane transporter activity
K6959_18395	COG0737	Belongs to the 5'-nucleotidase family
K6959_18405	COG0583	DNA-binding transcription factor activity
K6959_18420	COG0346	lactoylglutathione lyase activity
K6959_18425	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
K6959_18430	COG1028	Short-chain dehydrogenase reductase Sdr
K6959_18445	COG1136	(ABC) transporter
K6959_18450	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6959_18460	COG0646	methionine synthase
K6959_18460	COG1410	methionine synthase
K6959_18465	COG0646	methionine synthase
K6959_18465	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6959_18470	COG0626	cystathionine gamma-synthase activity
K6959_18515	COG1027	Aspartate ammonia-lyase