locus-tag	class	description
I5S86_00020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_00025	COG5001	Diguanylate cyclase
I5S86_00025	COG3300	MHYT domain
I5S86_00035	COG1802	Transcriptional regulator
I5S86_00090	COG1960	acyl-CoA dehydrogenase activity
I5S86_00095	COG0583	DNA-binding transcription factor activity
I5S86_00115	COG0427	acetyl-CoA hydrolase
I5S86_00150	COG2851	Citrate transporter
I5S86_00155	COG0861	Integral membrane protein TerC family
I5S86_00160	COG1283	sodium-dependent phosphate transmembrane transporter activity
I5S86_00175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5S86_00180	COG1127	ABC transporter
I5S86_00195	COG0700	Nucleoside recognition
I5S86_00200	COG1301	dicarboxylic acid transport
I5S86_00225	COG2204	response regulator
I5S86_00230	COG5002	protein histidine kinase activity
I5S86_00235	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5S86_00240	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5S86_00255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5S86_00265	COG3245	cytochrome
I5S86_00270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I5S86_00290	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I5S86_00295	COG0735	belongs to the Fur family
I5S86_00300	COG1121	(ABC) transporter
I5S86_00305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5S86_00320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5S86_00325	COG2011	ABC-type metal ion transport system permease component
I5S86_00360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_00365	COG0765	amino acid transport
I5S86_00370	COG5016	pyruvate
I5S86_00370	COG0511	ligase activity, forming carbon-carbon bonds
I5S86_00375	COG0439	Biotin carboxylase
I5S86_00380	COG0583	DNA-binding transcription factor activity
I5S86_00390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5S86_00410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5S86_00410	COG4651	solute:proton antiporter activity
I5S86_00415	COG1607	acyl-coa hydrolase
I5S86_00420	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I5S86_00430	COG0523	cobalamin synthesis protein
I5S86_00450	COG1469	GTP cyclohydrolase I activity
I5S86_00460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5S86_00465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5S86_00470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5S86_00475	COG0640	Transcriptional regulator
I5S86_00480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I5S86_00485	COG0798	PFAM Bile acid sodium symporter
I5S86_00490	COG0431	NADPH-dependent FMN reductase
I5S86_00495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5S86_00540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5S86_00565	COG0066	3-isopropylmalate dehydratase activity
I5S86_00570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I5S86_00575	COG1017	nitric oxide dioxygenase activity
I5S86_00575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5S86_00580	COG0840	transmembrane signaling receptor activity
I5S86_00610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I5S86_00660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5S86_00665	COG1349	DNA-binding transcription factor activity
I5S86_00670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I5S86_00675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I5S86_00680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I5S86_00685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I5S86_00690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I5S86_00695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I5S86_00700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I5S86_00710	COG0356	it plays a direct role in the translocation of protons across the membrane
I5S86_00715	COG3312	ion transport
I5S86_00720	COG1475	DNA binding
I5S86_00725	COG1192	Involved in chromosome partitioning
I5S86_00730	COG0357	Ribosomal RNA small subunit methyltransferase G
I5S86_00735	COG0445	tRNA wobble uridine modification
I5S86_00740	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I5S86_00745	COG0706	membrane insertase activity
I5S86_00750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I5S86_00755	COG0594	ribonuclease P activity
I5S86_00760	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I5S86_00765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I5S86_00770	COG0592	DNA-directed DNA polymerase activity
I5S86_00775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5S86_00780	COG0187	DNA topoisomerase II activity
I5S86_00840	COG2194	sulfuric ester hydrolase activity
I5S86_00890	COG0463	Glycosyl transferase, family 2
I5S86_00980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I5S86_01055	COG1252	NADH dehydrogenase
I5S86_01075	COG0477	Major facilitator Superfamily
I5S86_01085	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I5S86_01090	COG0751	glycine-tRNA ligase activity
I5S86_01095	COG0752	glycyl-tRNA synthetase alpha subunit
I5S86_01100	COG2818	Glycosylase
I5S86_01115	COG0569	domain protein
I5S86_01120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I5S86_01125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I5S86_01130	COG0242	peptide deformylase activity
I5S86_01135	COG3344	reverse transcriptase
I5S86_01140	COG0758	DNA mediated transformation
I5S86_01145	COG0009	L-threonylcarbamoyladenylate synthase
I5S86_01160	COG0408	coproporphyrinogen oxidase activity
I5S86_01165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5S86_01170	COG0659	secondary active sulfate transmembrane transporter activity
I5S86_01180	COG3119	arylsulfatase activity
I5S86_01200	COG0159	tryptophan synthase activity
I5S86_01205	COG0133	tryptophan synthase activity
I5S86_01220	COG3360	Dodecin
I5S86_01230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5S86_01235	COG1764	response to oxidative stress
I5S86_01265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5S86_01270	COG0339	signal peptide processing
I5S86_01275	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I5S86_01295	COG0659	secondary active sulfate transmembrane transporter activity
I5S86_01310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5S86_01315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5S86_01320	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I5S86_01345	COG1612	heme a metabolic process
I5S86_01350	COG0109	protoheme IX farnesyltransferase activity
I5S86_01380	COG1027	Aspartate ammonia-lyase
I5S86_01385	COG0583	DNA-binding transcription factor activity
I5S86_01420	COG1607	acyl-coa hydrolase
I5S86_01425	COG0477	Major facilitator Superfamily
I5S86_01440	COG0581	inorganic phosphate transmembrane transporter activity
I5S86_01445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5S86_01450	COG0704	Plays a role in the regulation of phosphate uptake
I5S86_01460	COG0739	heme binding
I5S86_01465	COG3657	addiction module killer protein
I5S86_01470	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5S86_01475	COG1253	flavin adenine dinucleotide binding
I5S86_01495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I5S86_01500	COG3161	chorismate lyase activity
I5S86_01530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5S86_01535	COG0583	DNA-binding transcription factor activity
I5S86_01545	COG0848	biopolymer transport protein
I5S86_01555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5S86_01570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5S86_01575	COG1758	RNA polymerase activity
I5S86_01585	COG0174	glutamine synthetase
I5S86_01590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5S86_01600	COG0194	GDP metabolic process
I5S86_01605	COG1561	YicC-like family, N-terminal region
I5S86_01610	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I5S86_01615	COG0708	Exodeoxyribonuclease III
I5S86_01620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I5S86_01625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5S86_01630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5S86_01635	COG0756	dUTP diphosphatase activity
I5S86_01640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5S86_01645	COG2003	Belongs to the UPF0758 family
I5S86_01650	COG0747	negative chemotaxis
I5S86_01655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I5S86_01660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I5S86_01675	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_01685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5S86_01690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5S86_01700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_01715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_01735	COG0427	acetyl-CoA hydrolase
I5S86_01740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5S86_01755	COG0534	Mate efflux family protein
I5S86_01770	COG5383	Protein conserved in bacteria
I5S86_01775	COG0583	DNA-binding transcription factor activity
I5S86_01780	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_01785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_01800	COG1335	isochorismatase
I5S86_01830	COG0583	DNA-binding transcription factor activity
I5S86_01850	COG0606	chelatase, subunit chli
I5S86_01895	COG1360	Flagellar Motor Protein
I5S86_01925	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I5S86_01930	COG1677	Flagellar hook-basal body complex protein FliE
I5S86_01935	COG1766	The M ring may be actively involved in energy transduction
I5S86_01940	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I5S86_01955	COG2882	bacterial-type flagellum organization
I5S86_01970	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I5S86_01990	COG1987	bacterial-type flagellum assembly
I5S86_02010	COG3951	Flagellar rod assembly protein muramidase FlgJ
I5S86_02010	COG1705	Flagellar rod assembly protein muramidase FlgJ
I5S86_02015	COG1706	bacterial-type flagellum-dependent cell motility
I5S86_02025	COG4786	Flagellar basal body rod
I5S86_02045	COG1558	bacterial-type flagellum-dependent cell motility
I5S86_02080	COG0347	Belongs to the P(II) protein family
I5S86_02085	COG0004	ammonium transporteR
I5S86_02095	COG0546	phosphoglycolate phosphatase activity
I5S86_02100	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I5S86_02110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I5S86_02115	COG0019	diaminopimelate decarboxylase activity
I5S86_02125	COG1965	Belongs to the frataxin family
I5S86_02135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5S86_02155	COG0625	glutathione transferase activity
I5S86_02160	COG0165	Argininosuccinate lyase
I5S86_02170	COG0181	hydroxymethylbilane synthase activity
I5S86_02190	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I5S86_02215	COG0488	(ABC) transporter
I5S86_02220	COG1280	lysine exporter protein (LysE YggA)
I5S86_02250	COG0517	IMP dehydrogenase activity
I5S86_02280	COG1522	sequence-specific DNA binding
I5S86_02295	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I5S86_02295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5S86_02300	COG0174	glutamine synthetase
I5S86_02305	COG0174	glutamine synthetase
I5S86_02325	COG3842	ATPase activity
I5S86_02330	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5S86_02335	COG1177	transmembrane transport
I5S86_02350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5S86_02360	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I5S86_02370	COG4208	sulfate ABC transporter
I5S86_02375	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I5S86_02430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_02440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5S86_02445	COG0277	FAD linked oxidase domain protein
I5S86_02450	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5S86_02455	COG3204	pilus organization
I5S86_02460	COG3204	pilus organization
I5S86_02465	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I5S86_02470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5S86_02485	COG0494	nUDIX hydrolase
I5S86_02490	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I5S86_02500	COG0730	response to heat
I5S86_02505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I5S86_02510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I5S86_02515	COG0789	Transcriptional regulator
I5S86_02525	COG0583	DNA-binding transcription factor activity
I5S86_02530	COG3842	ATPase activity
I5S86_02535	COG1178	ABC-type Fe3 transport system permease component
I5S86_02540	COG1840	ABC-type Fe3 transport system, periplasmic component
I5S86_02545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I5S86_02560	COG1823	symporter activity
I5S86_02570	COG0129	dihydroxy-acid dehydratase activity
I5S86_02575	COG2239	Acts as a magnesium transporter
I5S86_02580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5S86_02590	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I5S86_02595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5S86_02600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I5S86_02605	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I5S86_02640	COG0612	Peptidase, M16
I5S86_02645	COG0742	ribosomal rna small subunit methyltransferase
I5S86_02650	COG0612	Peptidase, M16
I5S86_02655	COG0612	Peptidase, M16
I5S86_02660	COG0552	protein localization to endoplasmic reticulum
I5S86_02665	COG2884	Cell division ATP-binding protein ftsE
I5S86_02670	COG2177	Part of the ABC transporter FtsEX involved in
I5S86_02680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5S86_02685	COG2363	Small membrane protein
I5S86_02695	COG2022	thiamine diphosphate biosynthetic process
I5S86_02700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I5S86_02710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5S86_02715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I5S86_02725	COG2813	Specifically methylates the guanine in position
I5S86_02725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5S86_02730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5S86_02755	COG0791	NLP P60 protein
I5S86_02770	COG0018	arginyl-trna synthetase
I5S86_02775	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5S86_02780	COG0254	rRNA binding
I5S86_02790	COG0281	malic enzyme
I5S86_02820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5S86_02825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I5S86_02835	COG0069	glutamate synthase activity
I5S86_02835	COG0070	glutamate synthase
I5S86_02835	COG0067	glutamate synthase
I5S86_02840	COG0493	'glutamate synthase
I5S86_02845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I5S86_02855	COG2814	Major facilitator Superfamily
I5S86_02860	COG0583	DNA-binding transcription factor activity
I5S86_02865	COG1192	Involved in chromosome partitioning
I5S86_02880	COG3118	belongs to the thioredoxin family
I5S86_02885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I5S86_02890	COG3264	Mechanosensitive ion channel
I5S86_02890	COG1196	nuclear chromosome segregation
I5S86_02895	COG3263	regulation of cellular component size
I5S86_02900	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I5S86_02905	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_02910	COG1309	transcriptional regulator
I5S86_02915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5S86_02925	COG2861	carbohydrate metabolic process
I5S86_02930	COG0793	Belongs to the peptidase S41A family
I5S86_02935	COG4942	peptidase
I5S86_02940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I5S86_02945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5S86_02955	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I5S86_02960	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I5S86_02975	COG3852	Histidine kinase
I5S86_02985	COG0301	tRNA thio-modification
I5S86_02985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5S86_02990	COG1217	gtp-binding protein TYPA
I5S86_03000	COG0058	SHG alpha-glucan phosphorylase activity
I5S86_03005	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I5S86_03030	COG0402	S-adenosylhomocysteine deaminase activity
I5S86_03035	COG2188	Transcriptional regulator
I5S86_03045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I5S86_03050	COG2986	histidine ammonia-lyase
I5S86_03060	COG1228	amidohydrolase
I5S86_03080	COG1490	D-aminoacyl-tRNA deacylase activity
I5S86_03085	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I5S86_03090	COG2943	transferase activity, transferring hexosyl groups
I5S86_03100	COG0765	amino acid transport
I5S86_03105	COG1126	abc transporter atp-binding protein
I5S86_03110	COG0840	transmembrane signaling receptor activity
I5S86_03115	COG0840	transmembrane signaling receptor activity
I5S86_03135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5S86_03140	COG0140	phosphoribosyl-ATP diphosphatase activity
I5S86_03145	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I5S86_03150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I5S86_03160	COG2226	methyltransferase
I5S86_03205	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I5S86_03210	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I5S86_03215	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I5S86_03220	COG0540	Belongs to the ATCase OTCase family
I5S86_03225	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I5S86_03230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I5S86_03235	COG1678	Uncharacterized ACR, COG1678
I5S86_03245	COG0189	ligase activity
I5S86_03270	COG2198	Histidine kinase
I5S86_03270	COG0784	Response regulator, receiver
I5S86_03270	COG0643	Histidine kinase
I5S86_03280	COG1272	protein, Hemolysin III
I5S86_03285	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5S86_03305	COG3038	cytochrome b561
I5S86_03310	COG2353	YceI-like domain
I5S86_03315	COG0513	Belongs to the DEAD box helicase family
I5S86_03330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I5S86_03335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I5S86_03375	COG1422	Protein of unknown function (DUF1090)
I5S86_03380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I5S86_03385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I5S86_03390	COG0640	Transcriptional regulator
I5S86_03400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5S86_03405	COG0126	phosphoglycerate kinase activity
I5S86_03425	COG5001	Diguanylate cyclase
I5S86_03425	COG3300	MHYT domain
I5S86_03430	COG1451	nucleotide metabolic process
I5S86_03445	COG1289	transmembrane transporter activity
I5S86_03450	COG2081	HI0933 family
I5S86_03455	COG0513	Belongs to the DEAD box helicase family
I5S86_03460	COG0477	Major facilitator Superfamily
I5S86_03465	COG0312	modulator of DNA gyrase
I5S86_03475	COG1960	acyl-CoA dehydrogenase activity
I5S86_03505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5S86_03510	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I5S86_03515	COG2192	nodulation
I5S86_03520	COG0438	transferase activity, transferring glycosyl groups
I5S86_03550	COG1132	(ABC) transporter
I5S86_03555	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I5S86_03555	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I5S86_03565	COG0667	Aldo Keto reductase
I5S86_03585	COG1519	Transferase
I5S86_03590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5S86_03600	COG0730	response to heat
I5S86_03605	COG4221	oxidoreductase activity
I5S86_03615	COG0437	4 iron, 4 sulfur cluster binding
I5S86_03620	COG2864	formate dehydrogenase
I5S86_03625	COG3058	Necessary for formate dehydrogenase activity
I5S86_03630	COG1921	L-seryl-tRNASec selenium transferase activity
I5S86_03635	COG3276	selenocysteine insertion sequence binding
I5S86_03645	COG0252	asparaginase activity
I5S86_03650	COG1115	amino acid carrier protein
I5S86_03665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5S86_03670	COG3047	cAMP biosynthetic process
I5S86_03685	COG0577	efflux transmembrane transporter activity
I5S86_03685	COG1136	(ABC) transporter
I5S86_03700	COG3118	belongs to the thioredoxin family
I5S86_03705	COG2264	protein methyltransferase activity
I5S86_03715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I5S86_03720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5S86_03720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5S86_03735	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I5S86_03740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5S86_03745	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I5S86_03750	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I5S86_03760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5S86_03770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5S86_03775	COG4206	TonB-dependent receptor
I5S86_03780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I5S86_03785	COG0142	geranyltranstransferase activity
I5S86_03790	COG1722	exodeoxyribonuclease VII activity
I5S86_03795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5S86_03800	COG2819	hydrolase of the alpha beta superfamily
I5S86_03845	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I5S86_03850	COG3228	Belongs to the MtfA family
I5S86_03855	COG0586	Pfam SNARE associated Golgi protein
I5S86_03860	COG0456	acetyltransferase
I5S86_03865	COG4302	ethanolamine ammonia-lyase activity
I5S86_03870	COG4303	Ethanolamine ammonia lyase large subunit
I5S86_03875	COG0531	amino acid
I5S86_03885	COG3284	Transcriptional regulator
I5S86_03890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5S86_03905	COG0702	epimerase
I5S86_03925	COG1346	cytolysis
I5S86_03935	COG0586	Pfam SNARE associated Golgi protein
I5S86_03940	COG2094	Belongs to the DNA glycosylase MPG family
I5S86_03945	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I5S86_03950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I5S86_03960	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I5S86_03965	COG0768	penicillin binding
I5S86_03970	COG0772	Belongs to the SEDS family
I5S86_03975	COG2951	lytic endotransglycosylase activity
I5S86_03985	COG1686	Belongs to the peptidase S11 family
I5S86_03990	COG2921	Belongs to the UPF0250 family
I5S86_03995	COG0321	lipoyl(octanoyl) transferase activity
I5S86_04000	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I5S86_04005	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5S86_04010	COG2951	lytic endotransglycosylase activity
I5S86_04030	COG0495	leucyl-tRNA aminoacylation
I5S86_04045	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I5S86_04050	COG4535	Mg2 and Co2 transporter CorC
I5S86_04055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I5S86_04060	COG1702	phosphate starvation-inducible protein PhoH
I5S86_04075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5S86_04080	COG0352	thiamine-phosphate diphosphorylase activity
I5S86_04085	COG0351	phosphomethylpyrimidine kinase
I5S86_04090	COG3850	Histidine kinase
I5S86_04090	COG3437	response regulator, receiver
I5S86_04090	COG2205	protein histidine kinase activity
I5S86_04090	COG4999	Histidine kinase
I5S86_04095	COG1960	acyl-CoA dehydrogenase activity
I5S86_04100	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5S86_04115	COG1522	sequence-specific DNA binding
I5S86_04160	COG0515	serine threonine protein kinase
I5S86_04160	COG2815	serine threonine protein kinase
I5S86_04165	COG1643	Atp-dependent helicase
I5S86_04175	COG3416	Protein conserved in bacteria
I5S86_04185	COG0697	spore germination
I5S86_04190	COG0513	Belongs to the DEAD box helicase family
I5S86_04200	COG0123	including yeast histone deacetylase and acetoin utilization protein
I5S86_04210	COG1946	Acyl-CoA thioesterase
I5S86_04215	COG0546	phosphoglycolate phosphatase activity
I5S86_04220	COG1064	alcohol dehydrogenase
I5S86_04225	COG1609	Transcriptional regulator
I5S86_04240	COG0583	DNA-binding transcription factor activity
I5S86_04245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5S86_04250	COG2271	Major facilitator Superfamily
I5S86_04305	COG0529	Catalyzes the synthesis of activated sulfate
I5S86_04345	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I5S86_04360	COG0582	viral genome integration into host DNA
I5S86_04400	COG1304	FMN binding
I5S86_04405	COG1620	l-lactate permease
I5S86_04415	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I5S86_04430	COG0735	belongs to the Fur family
I5S86_04435	COG0497	DNA recombination
I5S86_04440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I5S86_04445	COG0443	Heat shock 70 kDa protein
I5S86_04450	COG0484	heat shock protein binding
I5S86_04455	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I5S86_04460	COG0505	Belongs to the CarA family
I5S86_04465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I5S86_04470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5S86_04485	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I5S86_04495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I5S86_04500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5S86_04505	COG0149	triose-phosphate isomerase activity
I5S86_04510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5S86_04525	COG0779	Required for maturation of 30S ribosomal subunits
I5S86_04530	COG0195	Participates in both transcription termination and antitermination
I5S86_04535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I5S86_04540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I5S86_04545	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I5S86_04550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I5S86_04555	COG1185	polyribonucleotide nucleotidyltransferase activity
I5S86_04560	COG2823	Periplasmic or secreted lipoprotein
I5S86_04585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5S86_04590	COG0166	Belongs to the GPI family
I5S86_04595	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I5S86_04600	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I5S86_04610	COG0617	tRNA 3'-terminal CCA addition
I5S86_04615	COG2204	response regulator
I5S86_04620	COG4191	Histidine kinase
I5S86_04630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5S86_04640	COG0436	Aminotransferase
I5S86_04645	COG1489	DNA binding
I5S86_04655	COG4558	Periplasmic binding protein
I5S86_04660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5S86_04665	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I5S86_04685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5S86_04695	COG3098	single-species biofilm formation
I5S86_04700	COG0028	Belongs to the TPP enzyme family
I5S86_04710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I5S86_04715	COG1183	phosphatidylcholine synthase activity
I5S86_04720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I5S86_04725	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I5S86_04755	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I5S86_04760	COG1074	ATP-dependent DNA helicase activity
I5S86_04765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5S86_04805	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5S86_04810	COG0583	DNA-binding transcription factor activity
I5S86_04820	COG0840	transmembrane signaling receptor activity
I5S86_04825	COG2321	neutral zinc metallopeptidase
I5S86_04830	COG3485	protocatechuate 3,4-dioxygenase
I5S86_04835	COG3485	protocatechuate 3,4-dioxygenase
I5S86_04840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5S86_04845	COG2252	PERMEase
I5S86_04855	COG1271	oxidase subunit
I5S86_04860	COG1294	oxidase, subunit
I5S86_04870	COG2813	Specifically methylates the guanine in position
I5S86_04875	COG2197	response regulator
I5S86_04885	COG1970	mechanosensitive ion channel activity
I5S86_04895	COG2233	PERMEase
I5S86_04905	COG3397	chitin binding
I5S86_04910	COG1966	Carbon starvation protein
I5S86_04915	COG2879	small protein
I5S86_04920	COG0523	cobalamin synthesis protein
I5S86_04930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5S86_04940	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I5S86_04970	COG0789	Transcriptional regulator
I5S86_04980	COG1366	Belongs to the anti-sigma-factor antagonist family
I5S86_04990	COG0596	Alpha beta hydrolase
I5S86_04995	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_05005	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I5S86_05025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5S86_05080	COG4977	sequence-specific DNA binding
I5S86_05115	COG2233	PERMEase
I5S86_05200	COG3039	Transposase
I5S86_05275	COG4964	Belongs to the GSP D family
I5S86_05330	COG3708	Transcriptional regulator
I5S86_05330	COG2207	Transcriptional regulator
I5S86_05345	COG2246	polysaccharide biosynthetic process
I5S86_05355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5S86_05360	COG0583	DNA-binding transcription factor activity
I5S86_05380	COG1566	PFAM secretion protein HlyD family protein
I5S86_05415	COG0300	oxidoreductase activity
I5S86_05425	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I5S86_05425	COG0662	Cupin 2, conserved barrel domain protein
I5S86_05440	COG1696	Membrane protein involved in D-alanine export
I5S86_05455	COG3420	alginic acid biosynthetic process
I5S86_05465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I5S86_05470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_05475	COG1215	transferase activity, transferring glycosyl groups
I5S86_05480	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I5S86_05500	COG1136	(ABC) transporter
I5S86_05505	COG0577	efflux transmembrane transporter activity
I5S86_05505	COG1136	(ABC) transporter
I5S86_05520	COG3022	response to hydroperoxide
I5S86_05530	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I5S86_05535	COG0315	cyclic pyranopterin monophosphate synthase activity
I5S86_05540	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I5S86_05550	COG0513	Belongs to the DEAD box helicase family
I5S86_05555	COG0400	carboxylic ester hydrolase activity
I5S86_05560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_05565	COG4597	amino acid ABC transporter
I5S86_05570	COG0765	amino acid transport
I5S86_05575	COG1126	abc transporter atp-binding protein
I5S86_05580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5S86_05590	COG0175	sulfate reduction
I5S86_05615	COG1522	sequence-specific DNA binding
I5S86_05635	COG0180	Tryptophanyl-tRNA synthetase
I5S86_05640	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5S86_05650	COG0667	Aldo Keto reductase
I5S86_05655	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I5S86_05660	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I5S86_05665	COG0723	plastoquinol--plastocyanin reductase activity
I5S86_05670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I5S86_05675	COG2857	Cytochrome c1
I5S86_05680	COG0625	glutathione transferase activity
I5S86_05685	COG2969	positive regulation of protein catabolic process
I5S86_05695	COG2823	Periplasmic or secreted lipoprotein
I5S86_05700	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I5S86_05705	COG0792	nuclease activity
I5S86_05710	COG3107	peptidoglycan biosynthetic process
I5S86_05725	COG2001	Belongs to the MraZ family
I5S86_05730	COG0275	rRNA processing
I5S86_05745	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I5S86_05750	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5S86_05755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5S86_05760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I5S86_05765	COG0772	Belongs to the SEDS family
I5S86_05770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I5S86_05775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5S86_05780	COG1181	Belongs to the D-alanine--D-alanine ligase family
I5S86_05795	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I5S86_05800	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I5S86_05810	COG0653	protein targeting
I5S86_05815	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I5S86_05825	COG0494	nUDIX hydrolase
I5S86_05830	COG2096	Adenosyltransferase
I5S86_05835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_05835	COG4191	Histidine kinase
I5S86_05845	COG1666	GTP binding
I5S86_05850	COG0668	transmembrane transport
I5S86_05860	COG2211	Major facilitator Superfamily
I5S86_05880	COG3030	protein affecting phage T7 exclusion by the F plasmid
I5S86_05885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I5S86_05890	COG0459	protein refolding
I5S86_05900	COG0642	Histidine kinase
I5S86_05910	COG3642	lipopolysaccharide core region biosynthetic process
I5S86_05920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5S86_05925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_05955	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I5S86_05965	COG0583	DNA-binding transcription factor activity
I5S86_05970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5S86_05980	COG1902	pentaerythritol trinitrate reductase activity
I5S86_06025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5S86_06030	COG0693	protein deglycase activity
I5S86_06065	COG2925	Exonuclease
I5S86_06075	COG0788	formyltetrahydrofolate deformylase activity
I5S86_06090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I5S86_06090	COG0438	transferase activity, transferring glycosyl groups
I5S86_06095	COG0840	transmembrane signaling receptor activity
I5S86_06100	COG0433	COG0433 Predicted ATPase
I5S86_06105	COG0306	phosphate transporter
I5S86_06115	COG1414	Transcriptional regulator
I5S86_06120	COG2814	Major facilitator Superfamily
I5S86_06125	COG0183	Belongs to the thiolase family
I5S86_06130	COG0477	Major facilitator Superfamily
I5S86_06135	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5S86_06140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5S86_06145	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5S86_06165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5S86_06170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_06175	COG1309	transcriptional regulator
I5S86_06180	COG0477	Major facilitator Superfamily
I5S86_06185	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I5S86_06195	COG0583	DNA-binding transcription factor activity
I5S86_06205	COG2910	NAD(P)H-binding
I5S86_06210	COG0583	DNA-binding transcription factor activity
I5S86_06220	COG2207	Transcriptional regulator
I5S86_06245	COG0477	Major facilitator Superfamily
I5S86_06255	COG4191	Histidine kinase
I5S86_06280	COG0584	glycerophosphoryl diester phosphodiesterase
I5S86_06290	COG2267	carboxylic ester hydrolase activity
I5S86_06315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I5S86_06360	COG0354	folic acid binding
I5S86_06365	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I5S86_06395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5S86_06400	COG0481	GTPase activity
I5S86_06405	COG0681	Belongs to the peptidase S26 family
I5S86_06410	COG0571	ribonuclease III activity
I5S86_06415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I5S86_06420	COG1381	Involved in DNA repair and RecF pathway recombination
I5S86_06425	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I5S86_06430	COG0500	methyltransferase
I5S86_06435	COG2226	methyltransferase
I5S86_06445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5S86_06460	COG4206	TonB-dependent receptor
I5S86_06465	COG4628	conserved protein (DUF2132)
I5S86_06475	COG2375	cellular response to nickel ion
I5S86_06480	COG1695	Transcriptional regulator
I5S86_06490	COG1113	amino acid transport
I5S86_06495	COG0069	glutamate synthase activity
I5S86_06500	COG1201	RNA secondary structure unwinding
I5S86_06505	COG0494	nUDIX hydrolase
I5S86_06510	COG0583	DNA-binding transcription factor activity
I5S86_06515	COG2267	carboxylic ester hydrolase activity
I5S86_06530	COG1126	abc transporter atp-binding protein
I5S86_06535	COG0765	amino acid transport
I5S86_06540	COG0765	amino acid transport
I5S86_06565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5S86_06575	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5S86_06580	COG3842	ATPase activity
I5S86_06585	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I5S86_06590	COG0243	molybdopterin cofactor binding
I5S86_06595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I5S86_06610	COG0450	alkyl hydroperoxide reductase
I5S86_06615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5S86_06620	COG0418	dihydroorotase activity
I5S86_06630	COG0137	argininosuccinate synthase activity
I5S86_06640	COG2197	response regulator
I5S86_06650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5S86_06655	COG4660	Part of a membrane complex involved in electron transport
I5S86_06660	COG4659	FMN binding
I5S86_06675	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5S86_06675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5S86_06680	COG0489	protein tyrosine kinase activity
I5S86_06685	COG1278	Cold shock
I5S86_06690	COG0717	Belongs to the dCTP deaminase family
I5S86_06705	COG1201	RNA secondary structure unwinding
I5S86_06715	COG1793	dna ligase
I5S86_06720	COG1793	dna ligase
I5S86_06720	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I5S86_06730	COG2366	antibiotic biosynthetic process
I5S86_06735	COG0653	protein targeting
I5S86_06745	COG3012	SEC-C Motif Domain Protein
I5S86_06775	COG1199	ATP-dependent helicase activity
I5S86_06790	COG2885	chlorophyll binding
I5S86_06795	COG0259	pyridoxamine-phosphate oxidase activity
I5S86_06805	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I5S86_06845	COG2084	Dehydrogenase
I5S86_06855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5S86_06875	COG1289	transmembrane transporter activity
I5S86_06885	COG1566	PFAM secretion protein HlyD family protein
I5S86_06900	COG3706	GGDEF domain
I5S86_06905	COG2116	formate transmembrane transporter activity
I5S86_06930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5S86_06940	COG0252	asparaginase activity
I5S86_06950	COG0625	glutathione transferase activity
I5S86_06985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I5S86_06995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5S86_07025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5S86_07030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5S86_07030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I5S86_07035	COG0745	RESPONSE REGULATOR receiver
I5S86_07040	COG2205	protein histidine kinase activity
I5S86_07070	COG1301	dicarboxylic acid transport
I5S86_07075	COG3091	SprT-like family
I5S86_07085	COG0037	tRNA processing
I5S86_07125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5S86_07130	COG5002	protein histidine kinase activity
I5S86_07130	COG0784	Response regulator, receiver
I5S86_07130	COG2205	protein histidine kinase activity
I5S86_07150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5S86_07155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5S86_07160	COG3956	TIGRFAM MazG family protein
I5S86_07165	COG3122	Protein conserved in bacteria
I5S86_07180	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5S86_07185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I5S86_07195	COG0628	permease
I5S86_07205	COG0791	NLP P60 protein
I5S86_07210	COG0791	NLP P60 protein
I5S86_07220	COG1797	cobyrinic acid a,c-diamide synthase activity
I5S86_07225	COG0778	Nitroreductase
I5S86_07230	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I5S86_07240	COG1492	cobalamin metabolic process
I5S86_07250	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I5S86_07255	COG0406	alpha-ribazole phosphatase activity
I5S86_07260	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I5S86_07265	COG1846	Transcriptional regulator
I5S86_07305	COG2205	protein histidine kinase activity
I5S86_07310	COG2188	Transcriptional regulator
I5S86_07325	COG0840	transmembrane signaling receptor activity
I5S86_07335	COG2076	Multidrug Resistance protein
I5S86_07340	COG2974	May be involved in recombination
I5S86_07365	COG0024	Methionine aminopeptidase
I5S86_07370	COG0243	molybdopterin cofactor binding
I5S86_07375	COG2146	nitrite reductase [NAD(P)H] activity
I5S86_07375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5S86_07380	COG2146	nitrite reductase [NAD(P)H] activity
I5S86_07380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5S86_07385	COG0583	DNA-binding transcription factor activity
I5S86_07395	COG0545	Peptidyl-prolyl cis-trans isomerase
I5S86_07400	COG3339	Conserved Protein
I5S86_07440	COG0395	ABC-type sugar transport system, permease component
I5S86_07460	COG0668	transmembrane transport
I5S86_07480	COG1362	aminopeptidase activity
I5S86_07485	COG0564	pseudouridine synthase activity
I5S86_07490	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I5S86_07495	COG2894	cell division
I5S86_07500	COG0850	regulation of cytokinetic process
I5S86_07505	COG1560	Kdo2-lipid A biosynthetic process
I5S86_07515	COG2853	Lipoprotein
I5S86_07535	COG2113	Glycine betaine
I5S86_07540	COG3162	membrane
I5S86_07545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5S86_07570	COG2197	response regulator
I5S86_07580	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_07585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5S86_07590	COG3089	Belongs to the UPF0270 family
I5S86_07595	COG1363	Peptidase, m42
I5S86_07600	COG0189	ligase activity
I5S86_07600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I5S86_07605	COG0367	asparagine synthase
I5S86_07610	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I5S86_07610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_07615	COG2326	polyphosphate kinase activity
I5S86_07620	COG0697	spore germination
I5S86_07625	COG0114	fumarate hydratase activity
I5S86_07635	COG0271	Belongs to the BolA IbaG family
I5S86_07640	COG1054	Belongs to the UPF0176 family
I5S86_07655	COG5002	protein histidine kinase activity
I5S86_07655	COG5001	Diguanylate cyclase
I5S86_07675	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_07680	COG0546	phosphoglycolate phosphatase activity
I5S86_07685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5S86_07690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I5S86_07700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I5S86_07710	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I5S86_07715	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I5S86_07725	COG0776	regulation of translation
I5S86_07735	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I5S86_07745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5S86_07760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5S86_07780	COG1091	dTDP-4-dehydrorhamnose reductase activity
I5S86_07840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_07845	COG1538	Outer membrane efflux protein
I5S86_07850	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I5S86_07860	COG0438	transferase activity, transferring glycosyl groups
I5S86_07875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5S86_07885	COG1555	photosystem II stabilization
I5S86_07895	COG0284	orotidine-5'-phosphate decarboxylase activity
I5S86_07905	COG1215	transferase activity, transferring glycosyl groups
I5S86_07920	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I5S86_07930	COG2130	NADP-dependent
I5S86_07935	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_07945	COG0840	transmembrane signaling receptor activity
I5S86_07950	COG3135	benzoate transporter
I5S86_07955	COG0625	glutathione transferase activity
I5S86_07965	COG0302	gtp cyclohydrolase
I5S86_08000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I5S86_08005	COG2814	Major facilitator Superfamily
I5S86_08010	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I5S86_08040	COG1368	sulfuric ester hydrolase activity
I5S86_08060	COG0519	Catalyzes the synthesis of GMP from XMP
I5S86_08065	COG0598	Magnesium transport protein CorA
I5S86_08070	COG0204	Acyl-transferase
I5S86_08120	COG2814	Major facilitator Superfamily
I5S86_08125	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_08130	COG0583	DNA-binding transcription factor activity
I5S86_08165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I5S86_08170	COG1764	response to oxidative stress
I5S86_08175	COG1846	Transcriptional regulator
I5S86_08180	COG0583	DNA-binding transcription factor activity
I5S86_08190	COG0583	DNA-binding transcription factor activity
I5S86_08200	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I5S86_08215	COG3384	dioxygenase
I5S86_08220	COG0500	methyltransferase
I5S86_08225	COG0501	Belongs to the peptidase M48B family
I5S86_08230	COG0436	Aminotransferase
I5S86_08235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5S86_08240	COG0386	Belongs to the glutathione peroxidase family
I5S86_08245	COG5002	protein histidine kinase activity
I5S86_08245	COG0784	Response regulator, receiver
I5S86_08245	COG2205	protein histidine kinase activity
I5S86_08255	COG1956	GAF domain-containing protein
I5S86_08370	COG0625	glutathione transferase activity
I5S86_08375	COG1131	(ABC) transporter
I5S86_08380	COG0842	Transport permease protein
I5S86_08390	COG0658	competence protein
I5S86_08390	COG2333	competence protein COMEC
I5S86_08395	COG0811	peptide transport
I5S86_08400	COG0848	biopolymer transport protein
I5S86_08405	COG1663	tetraacyldisaccharide 4'-kinase activity
I5S86_08410	COG2835	tetraacyldisaccharide 4'-kinase activity
I5S86_08415	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I5S86_08420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I5S86_08425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I5S86_08430	COG1530	ribonuclease E activity
I5S86_08440	COG0546	phosphoglycolate phosphatase activity
I5S86_08445	COG0616	signal peptide processing
I5S86_08445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5S86_08450	COG0424	maF-like protein
I5S86_08460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I5S86_08465	COG0416	fatty acid biosynthetic process
I5S86_08480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5S86_08485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5S86_08495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5S86_08500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I5S86_08510	COG0084	hydrolase, TatD family'
I5S86_08515	COG1104	cysteine desulfurase activity
I5S86_08550	COG0556	nucleotide-excision repair
I5S86_08555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5S86_08595	COG0596	Alpha beta hydrolase
I5S86_08605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5S86_08625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I5S86_08630	COG0066	3-isopropylmalate dehydratase activity
I5S86_08635	COG2226	methyltransferase
I5S86_08640	COG0473	3-isopropylmalate dehydrogenase activity
I5S86_08665	COG0135	phosphoribosylanthranilate isomerase activity
I5S86_08670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I5S86_08675	COG0285	dihydrofolate synthase activity
I5S86_08685	COG1286	toxin biosynthetic process
I5S86_08745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5S86_08760	COG2358	TRAP transporter, solute receptor (TAXI family
I5S86_08765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5S86_08770	COG1902	pentaerythritol trinitrate reductase activity
I5S86_08770	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5S86_08780	COG3038	cytochrome b561
I5S86_08790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I5S86_08795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5S86_08805	COG3139	Protein of unknown function (DUF1315)
I5S86_08815	COG0308	aminopeptidase N
I5S86_08835	COG2706	6-phosphogluconolactonase activity
I5S86_08850	COG0420	3'-5' exonuclease activity
I5S86_08885	COG0714	Associated with various cellular activities
I5S86_08905	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I5S86_08920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5S86_08935	COG0668	transmembrane transport
I5S86_08955	COG0515	serine threonine protein kinase
I5S86_08955	COG2815	serine threonine protein kinase
I5S86_08960	COG2223	nitrite transmembrane transporter activity
I5S86_08965	COG3707	response regulator
I5S86_08970	COG1116	anion transmembrane transporter activity
I5S86_08970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5S86_08975	COG0167	dihydroorotate dehydrogenase activity
I5S86_08980	COG3130	regulation of translation
I5S86_08985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5S86_08985	COG0116	Belongs to the methyltransferase superfamily
I5S86_08995	COG2027	D-alanyl-D-alanine carboxypeptidase
I5S86_09000	COG3171	Protein conserved in bacteria
I5S86_09005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_09005	COG2205	protein histidine kinase activity
I5S86_09010	COG2197	response regulator
I5S86_09035	COG0004	ammonium transporteR
I5S86_09060	COG0840	transmembrane signaling receptor activity
I5S86_09070	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I5S86_09075	COG0425	Belongs to the sulfur carrier protein TusA family
I5S86_09080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5S86_09110	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5S86_09125	COG1597	lipid kinase activity
I5S86_09130	COG2197	response regulator
I5S86_09135	COG3851	Histidine kinase
I5S86_09145	COG0835	chemotaxis
I5S86_09145	COG0784	Response regulator, receiver
I5S86_09155	COG0741	lytic transglycosylase activity
I5S86_09160	COG0488	(ABC) transporter
I5S86_09165	COG0589	response to stress
I5S86_09175	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5S86_09175	COG1024	Enoyl-CoA hydratase
I5S86_09180	COG0183	Belongs to the thiolase family
I5S86_09210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5S86_09230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5S86_09240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I5S86_09250	COG1477	protein flavinylation
I5S86_09255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5S86_09260	COG0584	glycerophosphoryl diester phosphodiesterase
I5S86_09270	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5S86_09275	COG1136	(ABC) transporter
I5S86_09280	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5S86_09300	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I5S86_09300	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I5S86_09315	COG2853	Lipoprotein
I5S86_09325	COG4566	intracellular signal transduction
I5S86_09340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5S86_09345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5S86_09355	COG2271	Major facilitator Superfamily
I5S86_09370	COG3766	membrane
I5S86_09380	COG0754	glutathionylspermidine amidase activity
I5S86_09395	COG3383	formate dehydrogenase (NAD+) activity
I5S86_09405	COG4178	(ABC) transporter
I5S86_09410	COG2135	peptidase activity
I5S86_09430	COG2132	Multicopper oxidase
I5S86_09435	COG1230	cation diffusion facilitator family transporter
I5S86_09475	COG0730	response to heat
I5S86_09480	COG0840	transmembrane signaling receptor activity
I5S86_09485	COG0583	DNA-binding transcription factor activity
I5S86_09505	COG2186	Transcriptional regulator
I5S86_09520	COG2423	ornithine cyclodeaminase activity
I5S86_09525	COG3284	Transcriptional regulator
I5S86_09530	COG3842	ATPase activity
I5S86_09545	COG0395	ABC-type sugar transport system, permease component
I5S86_09560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I5S86_09590	COG0544	peptidyl-prolyl cis-trans isomerase activity
I5S86_09595	COG0740	serine-type endopeptidase activity
I5S86_09600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I5S86_09605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5S86_09655	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I5S86_09660	COG2259	Doxx family
I5S86_09670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5S86_09690	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I5S86_09695	COG4181	ATPase activity
I5S86_09710	COG1376	ErfK ybiS ycfS ynhG family protein
I5S86_09710	COG1388	LysM domain
I5S86_09730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5S86_09735	COG0589	response to stress
I5S86_09765	COG4067	protein conserved in archaea
I5S86_09765	COG0189	ligase activity
I5S86_09770	COG1802	Transcriptional regulator
I5S86_09780	COG0372	Belongs to the citrate synthase family
I5S86_09795	COG2079	MmgE PrpD family protein
I5S86_09815	COG0720	synthase
I5S86_09845	COG0517	IMP dehydrogenase activity
I5S86_09860	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5S86_09880	COG0745	RESPONSE REGULATOR receiver
I5S86_09885	COG4251	negative regulation of phosphorylation
I5S86_09925	COG2866	Carboxypeptidase
I5S86_09960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5S86_09965	COG1960	acyl-CoA dehydrogenase activity
I5S86_09970	COG0318	PFAM AMP-dependent synthetase and ligase
I5S86_09985	COG0366	Alpha amylase catalytic
I5S86_09990	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I5S86_10015	COG1640	4-alpha-glucanotransferase
I5S86_10020	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I5S86_10025	COG0297	glycogen (starch) synthase activity
I5S86_10035	COG4774	siderophore transport
I5S86_10040	COG3712	iron ion homeostasis
I5S86_10045	COG1595	DNA-templated transcription, initiation
I5S86_10055	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I5S86_10060	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5S86_10065	COG3387	PFAM Glycoside hydrolase 15-related
I5S86_10070	COG1309	transcriptional regulator
I5S86_10090	COG1953	Uracil, thiamine, allantoin
I5S86_10100	COG1234	tRNA 3'-trailer cleavage
I5S86_10105	COG3040	lipid binding
I5S86_10110	COG1024	Enoyl-CoA hydratase
I5S86_10115	COG2816	NAD+ diphosphatase activity
I5S86_10130	COG0174	glutamine synthetase
I5S86_10135	COG1396	sequence-specific DNA binding
I5S86_10140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_10145	COG0596	Alpha beta hydrolase
I5S86_10150	COG1238	metal cluster binding
I5S86_10160	COG0826	peptidase U32
I5S86_10195	COG1007	ATP synthesis coupled electron transport
I5S86_10210	COG0713	ATP synthesis coupled electron transport
I5S86_10220	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5S86_10225	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I5S86_10230	COG1034	ATP synthesis coupled electron transport
I5S86_10245	COG0649	NAD binding
I5S86_10245	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5S86_10250	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5S86_10255	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5S86_10270	COG2814	Major facilitator Superfamily
I5S86_10295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5S86_10300	COG1879	ABC-type sugar transport system periplasmic component
I5S86_10320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I5S86_10325	COG0316	Belongs to the HesB IscA family
I5S86_10325	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I5S86_10330	COG1999	signal sequence binding
I5S86_10385	COG0583	DNA-binding transcription factor activity
I5S86_10390	COG0417	DNA replication proofreading
I5S86_10400	COG2259	Doxx family
I5S86_10430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5S86_10435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I5S86_10450	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I5S86_10455	COG0765	amino acid transport
I5S86_10460	COG0765	amino acid transport
I5S86_10465	COG1126	abc transporter atp-binding protein
I5S86_10470	COG1192	Involved in chromosome partitioning
I5S86_10500	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I5S86_10505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5S86_10520	COG3842	ATPase activity
I5S86_10525	COG1177	transmembrane transport
I5S86_10530	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5S86_10540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5S86_10550	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_10555	COG4191	Histidine kinase
I5S86_10555	COG0784	Response regulator, receiver
I5S86_10560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5S86_10570	COG1285	pathogenesis
I5S86_10580	COG0789	Transcriptional regulator
I5S86_10585	COG2207	Transcriptional regulator
I5S86_10605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_10625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5S86_10635	COG0252	asparaginase activity
I5S86_10645	COG1129	ABC transporter
I5S86_10650	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5S86_10655	COG1609	Transcriptional regulator
I5S86_10660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5S86_10665	COG1869	D-ribose catabolic process
I5S86_10685	COG1278	Cold shock
I5S86_10695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5S86_10700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I5S86_10705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I5S86_10710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I5S86_10715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I5S86_10720	COG0072	phenylalanine-tRNA ligase activity
I5S86_10725	COG0776	regulation of translation
I5S86_10910	COG3646	Phage regulatory protein
I5S86_10955	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I5S86_10970	COG1598	PFAM Uncharacterised protein family UPF0150
I5S86_10975	COG1724	mRNA binding
I5S86_11225	COG2890	protein-(glutamine-N5) methyltransferase activity
I5S86_11225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I5S86_11240	COG0583	DNA-binding transcription factor activity
I5S86_11255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5S86_11255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5S86_11260	COG0019	diaminopimelate decarboxylase activity
I5S86_11280	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I5S86_11290	COG2186	Transcriptional regulator
I5S86_11310	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_11335	COG0028	Belongs to the TPP enzyme family
I5S86_11345	COG3618	amidohydrolase
I5S86_11350	COG2159	amidohydrolase
I5S86_11400	COG0583	DNA-binding transcription factor activity
I5S86_11430	COG3321	synthase
I5S86_11430	COG0604	alcohol dehydrogenase
I5S86_11440	COG0302	gtp cyclohydrolase
I5S86_11470	COG2828	Protein conserved in bacteria
I5S86_11475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5S86_11480	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5S86_11485	COG0583	DNA-binding transcription factor activity
I5S86_11495	COG3384	dioxygenase
I5S86_11520	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_11525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5S86_11530	COG2271	Major facilitator Superfamily
I5S86_11540	COG2113	Glycine betaine
I5S86_11545	COG3448	diguanylate cyclase activity
I5S86_11545	COG4175	Glycine betaine
I5S86_11550	COG4176	ABC-type proline glycine betaine transport system permease component
I5S86_11555	COG4176	ABC-type proline glycine betaine transport system permease component
I5S86_11565	COG0667	Aldo Keto reductase
I5S86_11575	COG1070	Carbohydrate kinase
I5S86_11580	COG0246	Mannitol dehydrogenase
I5S86_11595	COG1175	transmembrane transport
I5S86_11630	COG1024	Enoyl-CoA hydratase
I5S86_11645	COG0183	Belongs to the thiolase family
I5S86_11650	COG1960	acyl-CoA dehydrogenase activity
I5S86_11655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I5S86_11670	COG2814	Major facilitator Superfamily
I5S86_11680	COG2233	PERMEase
I5S86_11685	COG0583	DNA-binding transcription factor activity
I5S86_11730	COG1064	alcohol dehydrogenase
I5S86_11760	COG0840	transmembrane signaling receptor activity
I5S86_11765	COG2056	Na+-H+ antiporter family
I5S86_11780	COG1566	PFAM secretion protein HlyD family protein
I5S86_11785	COG2814	Major facilitator Superfamily
I5S86_11820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5S86_11825	COG1121	(ABC) transporter
I5S86_11865	COG1686	Belongs to the peptidase S11 family
I5S86_11875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5S86_11915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I5S86_11925	COG2205	protein histidine kinase activity
I5S86_11930	COG0784	Response regulator, receiver
I5S86_11930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_11930	COG2198	Histidine kinase
I5S86_11930	COG2205	protein histidine kinase activity
I5S86_11935	COG0113	porphobilinogen synthase activity
I5S86_11945	COG0307	riboflavin synthase, alpha
I5S86_11960	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I5S86_11970	COG1984	allophanate hydrolase subunit 2
I5S86_11990	COG4106	trans-aconitate 2-methyltransferase activity
I5S86_12000	COG0019	diaminopimelate decarboxylase activity
I5S86_12020	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5S86_12025	COG0583	DNA-binding transcription factor activity
I5S86_12050	COG1309	transcriptional regulator
I5S86_12055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I5S86_12055	COG2010	Cytochrome c
I5S86_12060	COG2080	2 iron, 2 sulfur cluster binding
I5S86_12065	COG1846	Transcriptional regulator
I5S86_12070	COG2309	aminopeptidase activity
I5S86_12075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5S86_12080	COG0596	Alpha beta hydrolase
I5S86_12085	COG3473	Maleate cis-trans isomerase
I5S86_12090	COG1335	isochorismatase
I5S86_12095	COG2271	Major facilitator Superfamily
I5S86_12105	COG1053	succinate dehydrogenase
I5S86_12115	COG0673	inositol 2-dehydrogenase activity
I5S86_12125	COG1053	succinate dehydrogenase
I5S86_12135	COG1053	succinate dehydrogenase
I5S86_12140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5S86_12145	COG1414	Transcriptional regulator
I5S86_12155	COG3237	CsbD-like
I5S86_12170	COG1228	amidohydrolase
I5S86_12205	COG1228	amidohydrolase
I5S86_12235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5S86_12275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5S86_12280	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I5S86_12295	COG1132	(ABC) transporter
I5S86_12310	COG0668	transmembrane transport
I5S86_12320	COG1450	Type ii and iii secretion system protein
I5S86_12335	COG3166	PFAM Fimbrial assembly family protein
I5S86_12340	COG3156	type II secretion system protein K
I5S86_12350	COG2165	general secretion pathway protein
I5S86_12355	COG4970	Tfp pilus assembly protein FimT
I5S86_12360	COG2165	general secretion pathway protein
I5S86_12365	COG1459	type II secretion system
I5S86_12370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5S86_12380	COG1472	Belongs to the glycosyl hydrolase 3 family
I5S86_12405	COG3220	belongs to the UPF0276 family
I5S86_12415	COG1595	DNA-templated transcription, initiation
I5S86_12420	COG4944	Protein of unknown function (DUF1109)
I5S86_12430	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5S86_12435	COG0183	Belongs to the thiolase family
I5S86_12450	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I5S86_12455	COG0247	lactate metabolic process
I5S86_12460	COG0277	FAD linked oxidase domain protein
I5S86_12465	COG0277	FAD linked oxidase domain protein
I5S86_12470	COG2186	Transcriptional regulator
I5S86_12495	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5S86_12505	COG0402	S-adenosylhomocysteine deaminase activity
I5S86_12535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5S86_12545	COG4106	trans-aconitate 2-methyltransferase activity
I5S86_12555	COG0583	DNA-binding transcription factor activity
I5S86_12565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_12570	COG0217	transcriptional regulatory protein
I5S86_12580	COG0076	glutamate decarboxylase activity
I5S86_12585	COG0477	Major facilitator Superfamily
I5S86_12590	COG1082	Xylose isomerase domain protein TIM barrel
I5S86_12590	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I5S86_12595	COG1309	transcriptional regulator
I5S86_12620	COG5001	Diguanylate cyclase
I5S86_12625	COG0656	L-ascorbic acid biosynthetic process
I5S86_12635	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I5S86_12645	COG0477	Major facilitator Superfamily
I5S86_12655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5S86_12660	COG3300	MHYT domain
I5S86_12660	COG5001	Diguanylate cyclase
I5S86_12665	COG1611	Belongs to the LOG family
I5S86_12670	COG2855	membrane
I5S86_12715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5S86_12735	COG0784	Response regulator, receiver
I5S86_12735	COG4191	Histidine kinase
I5S86_12740	COG2816	NAD+ diphosphatase activity
I5S86_12745	COG2186	Transcriptional regulator
I5S86_12750	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5S86_12760	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_12765	COG2267	carboxylic ester hydrolase activity
I5S86_12775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5S86_12785	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5S86_12800	COG1959	2 iron, 2 sulfur cluster binding
I5S86_12810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I5S86_12820	COG4991	sh3 domain protein
I5S86_12835	COG3180	Ammonia monooxygenase
I5S86_12840	COG0583	DNA-binding transcription factor activity
I5S86_12845	COG1252	NADH dehydrogenase
I5S86_12860	COG0393	Putative heavy-metal-binding
I5S86_12900	COG4221	oxidoreductase activity
I5S86_12910	COG1396	sequence-specific DNA binding
I5S86_12910	COG1917	Cupin 2, conserved barrel domain protein
I5S86_12915	COG0477	Major facilitator Superfamily
I5S86_12920	COG3038	cytochrome b561
I5S86_12925	COG0753	catalase activity
I5S86_12930	COG1595	DNA-templated transcription, initiation
I5S86_12940	COG0708	Exodeoxyribonuclease III
I5S86_12950	COG0729	surface antigen
I5S86_12955	COG2911	Protein conserved in bacteria
I5S86_12990	COG2366	antibiotic biosynthetic process
I5S86_12995	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5S86_13005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5S86_13010	COG0215	cysteine-tRNA ligase activity
I5S86_13020	COG0745	RESPONSE REGULATOR receiver
I5S86_13025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I5S86_13040	COG0829	nickel cation binding
I5S86_13045	COG0831	urea catabolic process
I5S86_13050	COG0832	Belongs to the urease beta subunit family
I5S86_13055	COG0804	urea catabolic process
I5S86_13060	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I5S86_13070	COG0830	nickel cation binding
I5S86_13075	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I5S86_13090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5S86_13095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5S86_13110	COG0587	DNA-directed DNA polymerase activity
I5S86_13115	COG0656	L-ascorbic acid biosynthetic process
I5S86_13125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I5S86_13135	COG2031	fatty acid transporter
I5S86_13150	COG1253	flavin adenine dinucleotide binding
I5S86_13160	COG2200	EAL domain
I5S86_13205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_13270	COG2204	response regulator
I5S86_13275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5S86_13300	COG1450	Type ii and iii secretion system protein
I5S86_13340	COG3145	DNA-N1-methyladenine dioxygenase activity
I5S86_13350	COG1280	lysine exporter protein (LysE YggA)
I5S86_13365	COG3773	Cell wall hydrolase
I5S86_13385	COG3257	ureidoglycine aminohydrolase activity
I5S86_13390	COG2226	methyltransferase
I5S86_13545	COG3209	COG3209 Rhs family protein
I5S86_13625	COG3436	PFAM IS66 Orf2 family protein
I5S86_13695	COG1473	amidohydrolase
I5S86_13705	COG0154	amidase activity
I5S86_13710	COG1414	Transcriptional regulator
I5S86_13715	COG1136	(ABC) transporter
I5S86_13720	COG0577	efflux transmembrane transporter activity
I5S86_13730	COG0667	Aldo Keto reductase
I5S86_13745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5S86_13750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I5S86_13760	COG2271	Major facilitator Superfamily
I5S86_13785	COG1609	Transcriptional regulator
I5S86_13795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5S86_13800	COG2271	Major facilitator Superfamily
I5S86_13810	COG0644	oxidoreductase
I5S86_13825	COG2814	Major facilitator Superfamily
I5S86_13830	COG0531	amino acid
I5S86_13850	COG3781	membrane
I5S86_13855	COG0784	Response regulator, receiver
I5S86_13855	COG4191	Histidine kinase
I5S86_13865	COG0714	Associated with various cellular activities
I5S86_13900	COG3119	arylsulfatase activity
I5S86_13915	COG3008	intermembrane lipid transfer
I5S86_13920	COG2995	paraquat-inducible protein a
I5S86_13935	COG2985	domain, Protein
I5S86_13940	COG0668	transmembrane transport
I5S86_13960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5S86_14005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5S86_14015	COG2207	Transcriptional regulator
I5S86_14030	COG0693	protein deglycase activity
I5S86_14035	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_14040	COG2323	membrane
I5S86_14045	COG0494	nUDIX hydrolase
I5S86_14070	COG3546	catalase activity
I5S86_14200	COG2217	Heavy metal translocating P-type atpase
I5S86_14205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5S86_14210	COG1074	ATP-dependent DNA helicase activity
I5S86_14245	COG2132	Multicopper oxidase
I5S86_14280	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5S86_14285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_14315	COG0789	Transcriptional regulator
I5S86_14340	COG1741	Belongs to the pirin family
I5S86_14345	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5S86_14350	COG2814	Major facilitator Superfamily
I5S86_14360	COG3038	cytochrome b561
I5S86_14375	COG0583	DNA-binding transcription factor activity
I5S86_14380	COG3038	cytochrome b561
I5S86_14385	COG2353	YceI-like domain
I5S86_14390	COG2353	YceI-like domain
I5S86_14430	COG0523	cobalamin synthesis protein
I5S86_14435	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5S86_14445	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_14465	COG1024	Enoyl-CoA hydratase
I5S86_14510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I5S86_14510	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5S86_14525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I5S86_14545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I5S86_14550	COG2218	PFAM glutamate synthase alpha subunit domain protein
I5S86_14555	COG0069	glutamate synthase activity
I5S86_14560	COG0004	ammonium transporteR
I5S86_14635	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I5S86_14690	COG1063	alcohol dehydrogenase
I5S86_14710	COG3568	Endonuclease Exonuclease Phosphatase
I5S86_14715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5S86_14720	COG0392	lysyltransferase activity
I5S86_14775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5S86_14780	COG2890	protein-(glutamine-N5) methyltransferase activity
I5S86_14810	COG2837	iron assimilation
I5S86_14825	COG1285	pathogenesis
I5S86_14830	COG2203	Gaf domain
I5S86_14830	COG4251	negative regulation of phosphorylation
I5S86_14830	COG5001	Diguanylate cyclase
I5S86_14830	COG3706	GGDEF domain
I5S86_14870	COG2423	ornithine cyclodeaminase activity
I5S86_14875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5S86_14880	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5S86_14905	COG3386	PFAM SMP-30 Gluconolaconase
I5S86_14910	COG0583	DNA-binding transcription factor activity
I5S86_14915	COG0367	asparagine synthase
I5S86_14920	COG0154	amidase activity
I5S86_14950	COG1929	Belongs to the glycerate kinase type-1 family
I5S86_14955	COG3835	regulator
I5S86_14960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5S86_14965	COG3284	Transcriptional regulator
I5S86_14970	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_14980	COG1902	pentaerythritol trinitrate reductase activity
I5S86_14985	COG0583	DNA-binding transcription factor activity
I5S86_15005	COG3135	benzoate transporter
I5S86_15010	COG3485	protocatechuate 3,4-dioxygenase
I5S86_15015	COG4829	muconolactone delta-isomerase
I5S86_15020	COG4948	Mandelate Racemase Muconate Lactonizing
I5S86_15025	COG2814	Major facilitator Superfamily
I5S86_15050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5S86_15055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5S86_15060	COG4166	transmembrane transport
I5S86_15065	COG4174	ABC transporter (Permease)
I5S86_15070	COG4239	(ABC) transporter, permease
I5S86_15075	COG3829	transcription factor binding
I5S86_15075	COG3290	protein histidine kinase activity
I5S86_15080	COG2610	gluconate transmembrane transporter activity
I5S86_15085	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_15090	COG4574	serine-type endopeptidase inhibitor activity
I5S86_15095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5S86_15100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5S86_15120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5S86_15135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5S86_15165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I5S86_15175	COG1301	dicarboxylic acid transport
I5S86_15185	COG0583	DNA-binding transcription factor activity
I5S86_15220	COG0488	(ABC) transporter
I5S86_15230	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I5S86_15235	COG0583	DNA-binding transcription factor activity
I5S86_15250	COG1968	undecaprenyl-diphosphatase activity
I5S86_15255	COG0840	transmembrane signaling receptor activity
I5S86_15305	COG2204	response regulator
I5S86_15335	COG0456	acetyltransferase
I5S86_15340	COG2433	Pfam Transposase IS66
I5S86_15350	COG2963	transposase activity
I5S86_15375	COG3813	Protein conserved in bacteria
I5S86_15380	COG2197	response regulator
I5S86_15385	COG2205	protein histidine kinase activity
I5S86_15385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_15395	COG1609	Transcriptional regulator
I5S86_15400	COG3265	gluconokinase activity
I5S86_15415	COG2204	response regulator
I5S86_15420	COG4191	Histidine kinase
I5S86_15425	COG5002	protein histidine kinase activity
I5S86_15430	COG0741	lytic transglycosylase activity
I5S86_15440	COG1459	type II secretion system
I5S86_15445	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I5S86_15490	COG0814	amino acid
I5S86_15495	COG1448	Aminotransferase
I5S86_15515	COG4215	(ABC) transporter
I5S86_15525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_15530	COG1126	abc transporter atp-binding protein
I5S86_15535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5S86_15540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5S86_15545	COG2271	Major facilitator Superfamily
I5S86_15550	COG2721	sulfolactate sulfo-lyase activity
I5S86_15555	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_15560	COG2186	Transcriptional regulator
I5S86_15575	COG0583	DNA-binding transcription factor activity
I5S86_15585	COG2391	methyltransferase activity
I5S86_15625	COG1944	ATP diphosphatase activity
I5S86_15645	COG3608	succinylglutamate desuccinylase aspartoacylase
I5S86_15645	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I5S86_15670	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_15675	COG2271	Major facilitator Superfamily
I5S86_15695	COG2205	protein histidine kinase activity
I5S86_15700	COG0745	RESPONSE REGULATOR receiver
I5S86_15705	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5S86_15730	COG3220	belongs to the UPF0276 family
I5S86_15740	COG2116	formate transmembrane transporter activity
I5S86_15745	COG2080	2 iron, 2 sulfur cluster binding
I5S86_15750	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I5S86_15755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I5S86_15770	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_15785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I5S86_15800	COG0840	transmembrane signaling receptor activity
I5S86_15805	COG0745	RESPONSE REGULATOR receiver
I5S86_15810	COG2205	protein histidine kinase activity
I5S86_15815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_15820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5S86_15840	COG2384	SAM-dependent methyltransferase
I5S86_15860	COG2184	nucleotidyltransferase activity
I5S86_15890	COG0826	peptidase U32
I5S86_15900	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_15925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5S86_15945	COG3052	prosthetic group binding
I5S86_15965	COG1960	acyl-CoA dehydrogenase activity
I5S86_16005	COG0583	DNA-binding transcription factor activity
I5S86_16010	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_16015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5S86_16025	COG0174	glutamine synthetase
I5S86_16035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_16040	COG1760	l-serine dehydratase
I5S86_16045	COG0583	DNA-binding transcription factor activity
I5S86_16050	COG2194	sulfuric ester hydrolase activity
I5S86_16065	COG1215	transferase activity, transferring glycosyl groups
I5S86_16075	COG2990	Protein conserved in bacteria
I5S86_16085	COG1045	serine acetyltransferase
I5S86_16095	COG0110	maltose O-acetyltransferase activity
I5S86_16125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I5S86_16190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5S86_16200	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5S86_16205	COG1215	transferase activity, transferring glycosyl groups
I5S86_16220	COG2205	protein histidine kinase activity
I5S86_16230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_16315	COG0346	lactoylglutathione lyase activity
I5S86_16330	COG0596	Alpha beta hydrolase
I5S86_16340	COG0210	DNA helicase
I5S86_16355	COG1199	ATP-dependent helicase activity
I5S86_16355	COG1199	ATP-dependent helicase activity
I5S86_16380	COG3321	synthase
I5S86_16380	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_16380	COG0604	alcohol dehydrogenase
I5S86_16390	COG0156	8-amino-7-oxononanoate synthase activity
I5S86_16395	COG2301	Belongs to the HpcH HpaI aldolase family
I5S86_16415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5S86_16450	COG0495	leucyl-tRNA aminoacylation
I5S86_16455	COG0028	Belongs to the TPP enzyme family
I5S86_16465	COG0406	alpha-ribazole phosphatase activity
I5S86_16485	COG2194	sulfuric ester hydrolase activity
I5S86_16505	COG0531	amino acid
I5S86_16510	COG3845	ABC transporter
I5S86_16515	COG4603	Belongs to the binding-protein-dependent transport system permease family
I5S86_16520	COG1079	Belongs to the binding-protein-dependent transport system permease family
I5S86_16535	COG3046	protein related to deoxyribodipyrimidine photolyase
I5S86_16560	COG0864	Transcriptional regulator
I5S86_16565	COG0747	negative chemotaxis
I5S86_16570	COG0601	transmembrane transport
I5S86_16575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5S86_16580	COG0444	Belongs to the ABC transporter superfamily
I5S86_16585	COG1124	(ABC) transporter
I5S86_16595	COG2308	Evidence 4 Homologs of previously reported genes of
I5S86_16605	COG1305	Transglutaminase-like
I5S86_16645	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_16655	COG0318	PFAM AMP-dependent synthetase and ligase
I5S86_16680	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I5S86_16705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5S86_16725	COG0583	DNA-binding transcription factor activity
I5S86_16745	COG2080	2 iron, 2 sulfur cluster binding
I5S86_16755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I5S86_16770	COG0702	epimerase
I5S86_16780	COG0667	Aldo Keto reductase
I5S86_16790	COG0667	Aldo Keto reductase
I5S86_16825	COG3064	Membrane
I5S86_16840	COG0583	DNA-binding transcription factor activity
I5S86_16845	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I5S86_16850	COG1960	acyl-CoA dehydrogenase activity
I5S86_16855	COG2079	MmgE PrpD family protein
I5S86_16885	COG0583	DNA-binding transcription factor activity
I5S86_16890	COG0405	Gamma-glutamyltransferase
I5S86_16915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5S86_16920	COG0768	penicillin binding
I5S86_16930	COG0861	Integral membrane protein TerC family
I5S86_16955	COG1104	cysteine desulfurase activity
I5S86_16965	COG0583	DNA-binding transcription factor activity
I5S86_16980	COG2814	Major facilitator Superfamily
I5S86_16985	COG1064	alcohol dehydrogenase
I5S86_16990	COG2207	Transcriptional regulator
I5S86_17010	COG0625	glutathione transferase activity
I5S86_17055	COG0477	Major facilitator Superfamily
I5S86_17060	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I5S86_17060	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I5S86_17060	COG0506	proline dehydrogenase activity
I5S86_17075	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I5S86_17095	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
I5S86_17110	COG3706	GGDEF domain
I5S86_17130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5S86_17135	COG0581	inorganic phosphate transmembrane transporter activity
I5S86_17145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I5S86_17160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5S86_17165	COG0697	spore germination
I5S86_17185	COG2067	long-chain fatty acid transport protein
I5S86_17190	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I5S86_17275	COG4974	Belongs to the 'phage' integrase family
I5S86_17310	COG0726	polysaccharide deacetylase
I5S86_17325	COG0174	glutamine synthetase
I5S86_17330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_17340	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_17385	COG1454	alcohol dehydrogenase
I5S86_17390	COG1960	acyl-CoA dehydrogenase activity
I5S86_17395	COG1024	Enoyl-CoA hydratase
I5S86_17395	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5S86_17400	COG0583	DNA-binding transcription factor activity
I5S86_17405	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I5S86_17425	COG0583	DNA-binding transcription factor activity
I5S86_17435	COG1960	acyl-CoA dehydrogenase activity
I5S86_17440	COG0318	PFAM AMP-dependent synthetase and ligase
I5S86_17450	COG2851	Citrate transporter
I5S86_17455	COG1301	dicarboxylic acid transport
I5S86_17460	COG2828	Protein conserved in bacteria
I5S86_17465	COG0583	DNA-binding transcription factor activity
I5S86_17470	COG5645	(Lipo)protein
I5S86_17480	COG1090	epimerase
I5S86_17490	COG2814	Major facilitator Superfamily
I5S86_17495	COG0583	DNA-binding transcription factor activity
I5S86_17500	COG0789	Transcriptional regulator
I5S86_17505	COG2202	Pas domain
I5S86_17505	COG1366	Belongs to the anti-sigma-factor antagonist family
I5S86_17515	COG4221	oxidoreductase activity
I5S86_17530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5S86_17550	COG2271	Major facilitator Superfamily
I5S86_17555	COG1253	flavin adenine dinucleotide binding
I5S86_17565	COG0583	DNA-binding transcription factor activity
I5S86_17570	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I5S86_17575	COG3132	Protein of unknown function, DUF480
I5S86_17585	COG3634	alkyl hydroperoxide reductase activity
I5S86_17610	COG3258	Cytochrome c
I5S86_17615	COG2863	cytochrome
I5S86_17650	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I5S86_17660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5S86_17665	COG0745	RESPONSE REGULATOR receiver
I5S86_17670	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I5S86_17675	COG0784	Response regulator, receiver
I5S86_17675	COG4191	Histidine kinase
I5S86_17685	COG2259	Doxx family
I5S86_17710	COG0583	DNA-binding transcription factor activity
I5S86_17715	COG3321	synthase
I5S86_17715	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_17715	COG0604	alcohol dehydrogenase
I5S86_17725	COG0616	signal peptide processing
I5S86_17745	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_17750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5S86_17780	COG0471	metal ion transport
I5S86_17780	COG0490	domain, Protein
I5S86_17785	COG2199	diguanylate cyclase activity
I5S86_17845	COG2885	chlorophyll binding
I5S86_17895	COG3179	chitinase
I5S86_17915	COG2885	chlorophyll binding
I5S86_17990	COG0629	single-stranded DNA binding
I5S86_17995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5S86_18165	COG1569	PIN domain
I5S86_18170	COG3311	Transcriptional regulator
I5S86_18225	COG2003	Belongs to the UPF0758 family
I5S86_18280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5S86_18280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5S86_18285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5S86_18290	COG1252	NADH dehydrogenase
I5S86_18295	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I5S86_18350	COG0583	DNA-binding transcription factor activity
I5S86_18360	COG0583	DNA-binding transcription factor activity
I5S86_18375	COG2837	iron assimilation
I5S86_18380	COG0582	viral genome integration into host DNA
I5S86_18395	COG0322	excinuclease ABC activity
I5S86_18415	COG2050	protein possibly involved in aromatic compounds catabolism
I5S86_18415	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I5S86_18420	COG1113	amino acid transport
I5S86_18425	COG0583	DNA-binding transcription factor activity
I5S86_18430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5S86_18445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5S86_18450	COG0659	secondary active sulfate transmembrane transporter activity
I5S86_18505	COG0840	transmembrane signaling receptor activity
I5S86_18510	COG1113	amino acid transport
I5S86_18540	COG2807	transmembrane transport
I5S86_18555	COG3842	ATPase activity
I5S86_18560	COG1177	transmembrane transport
I5S86_18565	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5S86_18570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5S86_18590	COG2508	Transcriptional regulator
I5S86_18595	COG0583	DNA-binding transcription factor activity
I5S86_18625	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5S86_18640	COG2271	Major facilitator Superfamily
I5S86_18665	COG1192	Involved in chromosome partitioning
I5S86_18710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5S86_18825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I5S86_18830	COG0386	Belongs to the glutathione peroxidase family
I5S86_18850	COG1024	Enoyl-CoA hydratase
I5S86_18855	COG1960	acyl-CoA dehydrogenase activity
I5S86_18860	COG1960	acyl-CoA dehydrogenase activity
I5S86_18870	COG2124	cytochrome p450
I5S86_18880	COG0183	Belongs to the thiolase family
I5S86_18885	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5S86_18890	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5S86_18920	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I5S86_18930	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5S86_18935	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_18980	COG2223	nitrite transmembrane transporter activity
I5S86_18985	COG0633	Ferredoxin
I5S86_18995	COG4221	oxidoreductase activity
I5S86_19010	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_19020	COG2124	cytochrome p450
I5S86_19025	COG1309	transcriptional regulator
I5S86_19035	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_19040	COG1024	Enoyl-CoA hydratase
I5S86_19055	COG4447	cellulose binding
I5S86_19070	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_19090	COG0583	DNA-binding transcription factor activity
I5S86_19095	COG1063	alcohol dehydrogenase
I5S86_19110	COG0840	transmembrane signaling receptor activity
I5S86_19130	COG1546	Belongs to the CinA family
I5S86_19130	COG1058	Belongs to the CinA family
I5S86_19140	COG2323	membrane
I5S86_19310	COG1238	metal cluster binding
I5S86_19335	COG1230	cation diffusion facilitator family transporter
I5S86_19345	COG2814	Major facilitator Superfamily
I5S86_19395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5S86_19455	COG2323	membrane
I5S86_19490	COG3920	Histidine kinase
I5S86_19565	COG1063	alcohol dehydrogenase
I5S86_19575	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_19580	COG3328	transposase activity
I5S86_19645	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_19655	COG1546	Belongs to the CinA family
I5S86_19655	COG1058	Belongs to the CinA family
I5S86_19675	COG3387	PFAM Glycoside hydrolase 15-related
I5S86_19695	COG2205	protein histidine kinase activity
I5S86_19760	COG4974	Belongs to the 'phage' integrase family
I5S86_19780	COG2233	PERMEase
I5S86_19805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5S86_19810	COG0435	Glutathione S-transferase
I5S86_19815	COG1648	precorrin-2 dehydrogenase activity
I5S86_19815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I5S86_19820	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I5S86_19830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5S86_19835	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I5S86_19840	COG1674	ftsk spoiiie
I5S86_19845	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I5S86_19850	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I5S86_19855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I5S86_19860	COG0542	response to heat
I5S86_19865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I5S86_19870	COG1278	Cold shock
I5S86_19890	COG0482	sulfurtransferase activity
I5S86_19895	COG2915	High frequency lysogenization protein hflD homolog
I5S86_19905	COG2850	peptidyl-arginine hydroxylation
I5S86_19910	COG2153	protein acetylation
I5S86_19925	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5S86_19930	COG2133	pyrroloquinoline quinone binding
I5S86_19960	COG0589	response to stress
I5S86_20025	COG1335	isochorismatase
I5S86_20040	COG2111	Na H antiporter
I5S86_20040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5S86_20045	COG1006	Multisubunit Na H antiporter MnhC subunit
I5S86_20050	COG0651	ATP synthesis coupled electron transport
I5S86_20060	COG2212	antiporter activity
I5S86_20065	COG1320	monovalent cation:proton antiporter activity
I5S86_20100	COG1024	Enoyl-CoA hydratase
I5S86_20105	COG1960	acyl-CoA dehydrogenase activity
I5S86_20110	COG0183	Belongs to the thiolase family
I5S86_20120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5S86_20125	COG2207	Transcriptional regulator
I5S86_20130	COG0583	DNA-binding transcription factor activity
I5S86_20135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5S86_20140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5S86_20145	COG0431	NADPH-dependent FMN reductase
I5S86_20160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5S86_20165	COG0328	RNA-DNA hybrid ribonuclease activity
I5S86_20175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5S86_20180	COG1388	LysM domain
I5S86_20180	COG0741	lytic transglycosylase activity
I5S86_20190	COG4166	transmembrane transport
I5S86_20195	COG4174	ABC transporter (Permease)
I5S86_20200	COG4239	(ABC) transporter, permease
I5S86_20205	COG4172	Belongs to the ABC transporter superfamily
I5S86_20210	COG1595	DNA-templated transcription, initiation
I5S86_20215	COG3712	iron ion homeostasis
I5S86_20225	COG2271	Major facilitator Superfamily
I5S86_20235	COG5001	Diguanylate cyclase
I5S86_20235	COG3706	GGDEF domain
I5S86_20235	COG2203	Gaf domain
I5S86_20235	COG4251	negative regulation of phosphorylation
I5S86_20240	COG0745	RESPONSE REGULATOR receiver
I5S86_20245	COG2205	protein histidine kinase activity
I5S86_20250	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I5S86_20260	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I5S86_20270	COG0628	permease
I5S86_20280	COG0596	Alpha beta hydrolase
I5S86_20300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I5S86_20315	COG4999	Histidine kinase
I5S86_20315	COG2205	protein histidine kinase activity
I5S86_20315	COG3437	response regulator, receiver
I5S86_20315	COG3850	Histidine kinase
I5S86_20320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I5S86_20335	COG1741	Belongs to the pirin family
I5S86_20345	COG0326	Molecular chaperone. Has ATPase activity
I5S86_20380	COG0045	succinate-CoA ligase (ADP-forming) activity
I5S86_20385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5S86_20405	COG1053	succinate dehydrogenase
I5S86_20410	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I5S86_20415	COG2009	succinate dehydrogenase
I5S86_20440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5S86_20445	COG2885	chlorophyll binding
I5S86_20445	COG3047	cAMP biosynthetic process
I5S86_20475	COG2944	sequence-specific DNA binding
I5S86_20485	COG0477	Major facilitator Superfamily
I5S86_20490	COG0784	Response regulator, receiver
I5S86_20490	COG2205	protein histidine kinase activity
I5S86_20490	COG2198	Histidine kinase
I5S86_20490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_20500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_20505	COG0577	efflux transmembrane transporter activity
I5S86_20505	COG1136	(ABC) transporter
I5S86_20510	COG1538	Outer membrane efflux protein
I5S86_20530	COG0515	serine threonine protein kinase
I5S86_20530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I5S86_20540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5S86_20550	COG0657	acetylesterase activity
I5S86_20560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5S86_20580	COG0642	Histidine kinase
I5S86_20595	COG3608	succinylglutamate desuccinylase aspartoacylase
I5S86_20595	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I5S86_20620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5S86_20655	COG3123	guanosine phosphorylase activity
I5S86_20665	COG3278	Belongs to the heme-copper respiratory oxidase family
I5S86_20680	COG2010	Cytochrome c
I5S86_20685	COG3278	Belongs to the heme-copper respiratory oxidase family
I5S86_20700	COG2010	Cytochrome c
I5S86_20705	COG0348	domain, Protein
I5S86_20715	COG2217	Heavy metal translocating P-type atpase
I5S86_20735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5S86_20740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5S86_20745	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I5S86_20750	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I5S86_20755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I5S86_20765	COG0789	Transcriptional regulator
I5S86_20775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I5S86_20780	COG3115	cell septum assembly
I5S86_20790	COG2186	Transcriptional regulator
I5S86_20810	COG0402	S-adenosylhomocysteine deaminase activity
I5S86_20815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I5S86_20825	COG2252	PERMEase
I5S86_20845	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I5S86_20855	COG2233	PERMEase
I5S86_20870	COG2354	Protein conserved in bacteria
I5S86_20885	COG3960	tartronate-semialdehyde synthase activity
I5S86_20890	COG3622	Belongs to the hyi family
I5S86_20895	COG2084	Dehydrogenase
I5S86_20905	COG0469	pyruvate kinase activity
I5S86_20915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5S86_20925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5S86_20925	COG0116	Belongs to the methyltransferase superfamily
I5S86_20935	COG1522	sequence-specific DNA binding
I5S86_20940	COG1953	Uracil, thiamine, allantoin
I5S86_20970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5S86_20995	COG1138	Cytochrome C-type biogenesis protein
I5S86_21000	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I5S86_21020	COG4133	protoheme IX ABC transporter activity
I5S86_21030	COG2257	FlhB HrpN YscU SpaS Family
I5S86_21045	COG0835	chemotaxis
I5S86_21055	COG1192	Involved in chromosome partitioning
I5S86_21060	COG1360	Flagellar Motor Protein
I5S86_21065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I5S86_21070	COG2201	protein-glutamate methylesterase activity
I5S86_21075	COG0643	Histidine kinase
I5S86_21075	COG0784	Response regulator, receiver
I5S86_21075	COG2198	Histidine kinase
I5S86_21080	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I5S86_21120	COG1987	bacterial-type flagellum assembly
I5S86_21160	COG0745	RESPONSE REGULATOR receiver
I5S86_21170	COG2882	bacterial-type flagellum organization
I5S86_21195	COG1677	Flagellar hook-basal body complex protein FliE
I5S86_21225	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I5S86_21235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5S86_21250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5S86_21255	COG2089	acid synthase
I5S86_21265	COG1083	cytidylyl-transferase
I5S86_21270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I5S86_21275	COG1086	Polysaccharide biosynthesis protein
I5S86_21315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I5S86_21320	COG0438	transferase activity, transferring glycosyl groups
I5S86_21320	COG1216	Glycosyl transferase, family 2
I5S86_21330	COG1256	bacterial-type flagellum assembly
I5S86_21340	COG1706	bacterial-type flagellum-dependent cell motility
I5S86_21345	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I5S86_21355	COG4787	bacterial-type flagellum-dependent cell motility
I5S86_21365	COG1749	Flagellar hook protein flgE
I5S86_21380	COG1815	bacterial-type flagellum-dependent cell motility
I5S86_21385	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I5S86_21390	COG0784	Response regulator, receiver
I5S86_21390	COG0835	chemotaxis
I5S86_21410	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I5S86_21415	COG0477	Major facilitator Superfamily
I5S86_21425	COG1522	sequence-specific DNA binding
I5S86_21430	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5S86_21435	COG0022	dehydrogenase e1 component
I5S86_21445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5S86_21500	COG1215	transferase activity, transferring glycosyl groups
I5S86_21505	COG2356	endonuclease I
I5S86_21515	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I5S86_21525	COG2239	Acts as a magnesium transporter
I5S86_21550	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5S86_21555	COG0527	aspartate kinase activity
I5S86_21560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I5S86_21565	COG2988	succinylglutamate desuccinylase activity
I5S86_21575	COG3724	N-succinylarginine dihydrolase activity
I5S86_21580	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_21595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5S86_21615	COG4215	(ABC) transporter
I5S86_21620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_21625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5S86_21645	COG2154	pterin-4-alpha-carbinolamine dehydratase
I5S86_21655	COG0277	FAD linked oxidase domain protein
I5S86_21655	COG0247	lactate metabolic process
I5S86_21660	COG0583	DNA-binding transcription factor activity
I5S86_21665	COG1113	amino acid transport
I5S86_21675	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I5S86_21685	COG0009	L-threonylcarbamoyladenylate synthase
I5S86_21695	COG2917	probably involved in intracellular septation
I5S86_21700	COG2350	Protein conserved in bacteria
I5S86_21705	COG0745	RESPONSE REGULATOR receiver
I5S86_21720	COG0778	Nitroreductase
I5S86_21725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5S86_21760	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5S86_21780	COG2832	Protein of unknown function (DUF454)
I5S86_21795	COG2274	protein secretion by the type I secretion system
I5S86_21800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_21815	COG3148	PFAM DTW domain containing protein
I5S86_21820	COG0840	transmembrane signaling receptor activity
I5S86_21835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5S86_21840	COG0583	DNA-binding transcription factor activity
I5S86_21850	COG0697	spore germination
I5S86_21875	COG3192	ethanolamine utilization protein
I5S86_21890	COG0513	Belongs to the DEAD box helicase family
I5S86_21895	COG0668	transmembrane transport
I5S86_21900	COG0679	Auxin Efflux Carrier
I5S86_21910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I5S86_21925	COG2267	carboxylic ester hydrolase activity
I5S86_21935	COG1132	(ABC) transporter
I5S86_21945	COG2188	Transcriptional regulator
I5S86_21955	COG1643	Atp-dependent helicase
I5S86_21960	COG0174	glutamine synthetase
I5S86_21965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_21970	COG0318	PFAM AMP-dependent synthetase and ligase
I5S86_21980	COG2267	carboxylic ester hydrolase activity
I5S86_21985	COG2030	dehydratase
I5S86_21990	COG4941	Belongs to the sigma-70 factor family
I5S86_22000	COG3795	YCII-related domain
I5S86_22040	COG0242	peptide deformylase activity
I5S86_22045	COG1295	ribonuclease BN
I5S86_22055	COG3420	alginic acid biosynthetic process
I5S86_22075	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I5S86_22105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5S86_22125	COG1984	allophanate hydrolase subunit 2
I5S86_22130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I5S86_22135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I5S86_22140	COG2814	Major facilitator Superfamily
I5S86_22155	COG0121	glutamine amidotransferase
I5S86_22200	COG2983	Belongs to the UPF0260 family
I5S86_22205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5S86_22210	COG3100	YcgL domain-containing protein
I5S86_22230	COG0626	cystathionine gamma-synthase activity
I5S86_22235	COG1522	sequence-specific DNA binding
I5S86_22240	COG0243	molybdopterin cofactor binding
I5S86_22245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I5S86_22250	COG3781	membrane
I5S86_22255	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5S86_22270	COG0531	amino acid
I5S86_22275	COG3938	Belongs to the proline racemase family
I5S86_22295	COG1902	pentaerythritol trinitrate reductase activity
I5S86_22300	COG0640	Transcriptional regulator
I5S86_22305	COG0579	oxidoreductase
I5S86_22320	COG1609	Transcriptional regulator
I5S86_22340	COG3328	transposase activity
I5S86_22360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I5S86_22365	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5S86_22370	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I5S86_22375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5S86_22385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5S86_22395	COG0425	Belongs to the sulfur carrier protein TusA family
I5S86_22400	COG4783	chaperone-mediated protein folding
I5S86_22405	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I5S86_22410	COG5339	Protein conserved in bacteria
I5S86_22415	COG0531	amino acid
I5S86_22420	COG0840	transmembrane signaling receptor activity
I5S86_22435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I5S86_22440	COG0602	queuosine metabolic process
I5S86_22445	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I5S86_22450	COG2885	chlorophyll binding
I5S86_22455	COG0823	Involved in the tonB-independent uptake of proteins
I5S86_22475	COG0824	Thioesterase
I5S86_22480	COG2255	four-way junction helicase activity
I5S86_22485	COG0632	four-way junction helicase activity
I5S86_22490	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I5S86_22495	COG0217	transcriptional regulatory protein
I5S86_22500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I5S86_22515	COG0783	Belongs to the Dps family
I5S86_22525	COG2900	Belongs to the SlyX family
I5S86_22540	COG0442	prolyl-tRNA aminoacylation
I5S86_22550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5S86_22580	COG3158	transport of potassium into the cell
I5S86_22585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I5S86_22600	COG4807	Protein conserved in bacteria
I5S86_22615	COG0583	DNA-binding transcription factor activity
I5S86_22630	COG3148	PFAM DTW domain containing protein
I5S86_22655	COG2137	regulation of response to DNA damage stimulus
I5S86_22660	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I5S86_22725	COG1247	-acetyltransferase
I5S86_22730	COG1473	amidohydrolase
I5S86_22735	COG0251	oxidation-reduction process
I5S86_22740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_22745	COG0477	Major facilitator Superfamily
I5S86_22750	COG0006	proline dipeptidase activity
I5S86_22755	COG2423	ornithine cyclodeaminase activity
I5S86_22760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5S86_22765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5S86_22775	COG0765	amino acid transport
I5S86_22780	COG0765	amino acid transport
I5S86_22785	COG1126	abc transporter atp-binding protein
I5S86_22790	COG1522	sequence-specific DNA binding
I5S86_22795	COG3608	succinylglutamate desuccinylase aspartoacylase
I5S86_22805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5S86_22925	COG1546	Belongs to the CinA family
I5S86_22940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I5S86_22945	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I5S86_22960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I5S86_22965	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I5S86_22970	COG0585	pseudouridine synthase activity
I5S86_22975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I5S86_22985	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I5S86_22995	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I5S86_23005	COG0148	phosphopyruvate hydratase activity
I5S86_23010	COG0504	CTP synthase activity
I5S86_23015	COG0037	tRNA processing
I5S86_23020	COG0825	malonyl-CoA metabolic process
I5S86_23030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I5S86_23035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5S86_23040	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5S86_23045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I5S86_23050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5S86_23070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I5S86_23080	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I5S86_23085	COG0233	cytoplasmic translational termination
I5S86_23090	COG0528	UMP kinase activity
I5S86_23095	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I5S86_23100	COG0052	Belongs to the universal ribosomal protein uS2 family
I5S86_23105	COG0024	Methionine aminopeptidase
I5S86_23110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I5S86_23115	COG0436	Aminotransferase
I5S86_23120	COG0025	NhaP-type Na H and K H
I5S86_23125	COG1393	Belongs to the ArsC family
I5S86_23130	COG2171	N-acyltransferase activity
I5S86_23135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5S86_23140	COG2166	iron-sulfur cluster assembly
I5S86_23145	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5S86_23150	COG1215	transferase activity, transferring glycosyl groups
I5S86_23155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5S86_23160	COG2226	methyltransferase
I5S86_23175	COG2937	Belongs to the GPAT DAPAT family
I5S86_23210	COG0742	ribosomal rna small subunit methyltransferase
I5S86_23230	COG1801	Protein of unknown function DUF72
I5S86_23245	COG0563	adenylate kinase activity
I5S86_23250	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I5S86_23265	COG2885	chlorophyll binding
I5S86_23275	COG1073	alpha beta
I5S86_23295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I5S86_23305	COG3706	GGDEF domain
I5S86_23305	COG5001	Diguanylate cyclase
I5S86_23305	COG4251	negative regulation of phosphorylation
I5S86_23305	COG2203	Gaf domain
I5S86_23310	COG2201	protein-glutamate methylesterase activity
I5S86_23325	COG0457	Tetratricopeptide repeat
I5S86_23325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I5S86_23335	COG0840	transmembrane signaling receptor activity
I5S86_23340	COG2979	Protein of unknown function (DUF533)
I5S86_23345	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_23360	COG1902	pentaerythritol trinitrate reductase activity
I5S86_23385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I5S86_23420	COG4974	Belongs to the 'phage' integrase family
I5S86_23430	COG1607	acyl-coa hydrolase
I5S86_23435	COG0335	large ribosomal subunit rRNA binding
I5S86_23440	COG0336	Belongs to the RNA methyltransferase TrmD family
I5S86_23445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I5S86_23450	COG0228	four-way junction DNA binding
I5S86_23455	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5S86_23465	COG4536	flavin adenine dinucleotide binding
I5S86_23470	COG0477	Major facilitator Superfamily
I5S86_23475	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I5S86_23495	COG0494	nUDIX hydrolase
I5S86_23545	COG4970	Tfp pilus assembly protein FimT
I5S86_23560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5S86_23595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5S86_23610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5S86_23610	COG0047	phosphoribosylformylglycinamidine synthase activity
I5S86_23615	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I5S86_23620	COG0590	tRNA wobble adenosine to inosine editing
I5S86_23635	COG0519	Catalyzes the synthesis of GMP from XMP
I5S86_23635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I5S86_23650	COG1570	exodeoxyribonuclease VII activity
I5S86_23655	COG0739	heme binding
I5S86_23660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5S86_23690	COG2084	Dehydrogenase
I5S86_23705	COG0800	Aldolase
I5S86_23720	COG1737	Transcriptional regulator
I5S86_23725	COG0676	glucose-6-phosphate 1-epimerase activity
I5S86_23735	COG3842	ATPase activity
I5S86_23745	COG1175	transmembrane transport
I5S86_23750	COG1653	transport
I5S86_23785	COG1595	DNA-templated transcription, initiation
I5S86_23805	COG2832	Protein of unknown function (DUF454)
I5S86_23820	COG2235	arginine
I5S86_23825	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I5S86_23845	COG0509	glycine decarboxylation via glycine cleavage system
I5S86_23850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5S86_23850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5S86_23855	COG1760	l-serine dehydratase
I5S86_23860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I5S86_23865	COG1278	Cold shock
I5S86_23875	COG0795	lipopolysaccharide-transporting ATPase activity
I5S86_23880	COG0795	lipopolysaccharide-transporting ATPase activity
I5S86_23885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I5S86_23900	COG0525	valine-tRNA ligase activity
I5S86_23905	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I5S86_23910	COG0776	regulation of translation
I5S86_23915	COG3081	Nucleoid-associated protein
I5S86_23920	COG2827	Endonuclease containing a URI domain
I5S86_23930	COG2807	transmembrane transport
I5S86_23935	COG2186	Transcriptional regulator
I5S86_23940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5S86_23945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I5S86_23950	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I5S86_23955	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I5S86_23975	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5S86_23980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5S86_23985	COG1127	ABC transporter
I5S86_23995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I5S86_24005	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I5S86_24010	COG1137	ATPase activity
I5S86_24015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I5S86_24020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5S86_24030	COG1660	Displays ATPase and GTPase activities
I5S86_24035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5S86_24065	COG0312	modulator of DNA gyrase
I5S86_24070	COG3028	Belongs to the UPF0307 family
I5S86_24075	COG0312	modulator of DNA gyrase
I5S86_24080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5S86_24095	COG0424	maF-like protein
I5S86_24105	COG1792	Involved in formation and maintenance of cell shape
I5S86_24110	COG1077	Cell shape determining protein MreB Mrl
I5S86_24115	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I5S86_24120	COG0154	amidase activity
I5S86_24125	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I5S86_24140	COG1113	amino acid transport
I5S86_24150	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I5S86_24165	COG0747	negative chemotaxis
I5S86_24170	COG0747	negative chemotaxis
I5S86_24180	COG0747	negative chemotaxis
I5S86_24185	COG0601	transmembrane transport
I5S86_24190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5S86_24195	COG0444	Belongs to the ABC transporter superfamily
I5S86_24200	COG4608	Belongs to the ABC transporter superfamily
I5S86_24215	COG0723	plastoquinol--plastocyanin reductase activity
I5S86_24215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_24230	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I5S86_24235	COG1396	sequence-specific DNA binding
I5S86_24240	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I5S86_24265	COG4772	TonB-dependent receptor
I5S86_24270	COG3712	iron ion homeostasis
I5S86_24280	COG0019	diaminopimelate decarboxylase activity
I5S86_24290	COG3128	pkhd-type hydroxylase
I5S86_24295	COG4774	siderophore transport
I5S86_24300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I5S86_24305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5S86_24310	COG0436	Aminotransferase
I5S86_24315	COG1160	GTP binding
I5S86_24330	COG0124	histidyl-tRNA synthetase
I5S86_24335	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I5S86_24350	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I5S86_24355	COG0105	UTP biosynthetic process
I5S86_24365	COG0633	Ferredoxin
I5S86_24370	COG0443	Heat shock 70 kDa protein
I5S86_24375	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I5S86_24380	COG0316	Belongs to the HesB IscA family
I5S86_24390	COG1104	cysteine desulfurase activity
I5S86_24400	COG1045	serine acetyltransferase
I5S86_24415	COG3134	Outer membrane lipoprotein
I5S86_24430	COG1862	Preprotein translocase
I5S86_24435	COG0343	queuine tRNA-ribosyltransferase activity
I5S86_24440	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I5S86_24460	COG3781	membrane
I5S86_24465	COG3639	organic phosphonate transmembrane transporter activity
I5S86_24470	COG3639	organic phosphonate transmembrane transporter activity
I5S86_24475	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I5S86_24480	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I5S86_24485	COG0709	Synthesizes selenophosphate from selenide and ATP
I5S86_24490	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I5S86_24520	COG0727	PFAM Uncharacterised protein family (UPF0153)
I5S86_24525	COG0436	Aminotransferase
I5S86_24530	COG0109	protoheme IX farnesyltransferase activity
I5S86_24535	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I5S86_24540	COG1845	cytochrome c oxidase, subunit III
I5S86_24545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5S86_24550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5S86_24555	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I5S86_24560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5S86_24560	COG1017	nitric oxide dioxygenase activity
I5S86_24565	COG3604	Transcriptional regulator
I5S86_24620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5S86_24645	COG2203	Gaf domain
I5S86_24645	COG5001	Diguanylate cyclase
I5S86_24645	COG3706	GGDEF domain
I5S86_24645	COG4251	negative regulation of phosphorylation
I5S86_24655	COG3530	Putative quorum-sensing-regulated virulence factor
I5S86_24660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5S86_24660	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I5S86_24660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5S86_24665	COG1105	Belongs to the carbohydrate kinase PfkB family
I5S86_24675	COG1609	Transcriptional regulator
I5S86_24680	COG0084	hydrolase, TatD family'
I5S86_24685	COG0840	transmembrane signaling receptor activity
I5S86_24695	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5S86_24710	COG0492	ferredoxin-NADP+ reductase activity
I5S86_24715	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I5S86_24735	COG0386	Belongs to the glutathione peroxidase family
I5S86_24750	COG0280	phosphate acetyltransferase
I5S86_24750	COG0857	belongs to the CobB CobQ family
I5S86_24755	COG2885	chlorophyll binding
I5S86_24760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5S86_24790	COG0318	PFAM AMP-dependent synthetase and ligase
I5S86_24795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5S86_24800	COG2813	Specifically methylates the guanine in position
I5S86_24805	COG2119	membrane
I5S86_24810	COG0501	Belongs to the peptidase M48B family
I5S86_24815	COG2135	peptidase activity
I5S86_24855	COG0579	oxidoreductase
I5S86_24875	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I5S86_24880	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I5S86_24890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I5S86_24895	COG1090	epimerase
I5S86_24900	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
I5S86_24905	COG3272	Protein of unknown function (DUF1722)
I5S86_24910	COG0789	Transcriptional regulator
I5S86_24920	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_24930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I5S86_24935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5S86_24945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I5S86_24950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I5S86_24960	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I5S86_24965	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I5S86_24975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I5S86_24980	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I5S86_24985	COG0193	aminoacyl-tRNA hydrolase activity
I5S86_25015	COG0628	permease
I5S86_25030	COG1335	isochorismatase
I5S86_25060	COG3264	Mechanosensitive ion channel
I5S86_25060	COG1511	domain protein
I5S86_25065	COG2169	Transcriptional regulator
I5S86_25065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5S86_25075	COG1595	DNA-templated transcription, initiation
I5S86_25100	COG2223	nitrite transmembrane transporter activity
I5S86_25120	COG0456	acetyltransferase
I5S86_25145	COG3045	CreA protein
I5S86_25150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I5S86_25155	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I5S86_25160	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I5S86_25165	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I5S86_25170	COG0142	geranyltranstransferase activity
I5S86_25175	COG2824	Alkylphosphonate utilization operon protein PhnA
I5S86_25185	COG0545	Peptidyl-prolyl cis-trans isomerase
I5S86_25195	COG2862	Uncharacterized protein family, UPF0114
I5S86_25205	COG1067	ATP-dependent peptidase activity
I5S86_25220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5S86_25225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5S86_25230	COG0488	(ABC) transporter
I5S86_25245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I5S86_25270	COG1846	Transcriptional regulator
I5S86_25275	COG0596	Alpha beta hydrolase
I5S86_25280	COG2807	transmembrane transport
I5S86_25285	COG2963	transposase activity
I5S86_25295	COG2433	Pfam Transposase IS66
I5S86_25300	COG0456	acetyltransferase
I5S86_25320	COG3012	SEC-C Motif Domain Protein
I5S86_25345	COG0582	viral genome integration into host DNA
I5S86_25370	COG0237	dephospho-CoA kinase activity
I5S86_25375	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I5S86_25395	COG1252	NADH dehydrogenase
I5S86_25415	COG0542	response to heat
I5S86_25440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_25470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I5S86_25475	COG1047	Peptidyl-prolyl cis-trans
I5S86_25480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I5S86_25485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I5S86_25490	COG0196	riboflavin kinase activity
I5S86_25500	COG0268	Binds directly to 16S ribosomal RNA
I5S86_25505	COG3008	intermembrane lipid transfer
I5S86_25510	COG2995	paraquat-inducible protein a
I5S86_25515	COG2995	paraquat-inducible protein a
I5S86_25560	COG1309	transcriptional regulator
I5S86_25570	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_25575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I5S86_25585	COG2814	Major facilitator Superfamily
I5S86_25590	COG2217	Heavy metal translocating P-type atpase
I5S86_25600	COG2217	Heavy metal translocating P-type atpase
I5S86_25610	COG0840	transmembrane signaling receptor activity
I5S86_25615	COG2207	Transcriptional regulator
I5S86_25625	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_25640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5S86_25670	COG4953	penicillin-binding protein 1C
I5S86_25680	COG2373	Large extracellular alpha-helical protein
I5S86_25685	COG0534	Mate efflux family protein
I5S86_25695	COG1166	arginine decarboxylase activity
I5S86_25700	COG0023	Translation Initiation Factor
I5S86_25730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I5S86_25745	COG2264	protein methyltransferase activity
I5S86_25755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5S86_25765	COG0138	bifunctional purine biosynthesis protein purh
I5S86_25770	COG0151	Belongs to the GarS family
I5S86_25780	COG2095	MarC family integral membrane protein
I5S86_25800	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5S86_25810	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I5S86_25835	COG0330	HflC and HflK could
I5S86_25855	COG4774	siderophore transport
I5S86_25865	COG1113	amino acid transport
I5S86_25885	COG0411	ABC transporter
I5S86_25900	COG0789	Transcriptional regulator
I5S86_25905	COG0484	heat shock protein binding
I5S86_25910	COG0443	Heat shock 70 kDa protein
I5S86_25930	COG0697	spore germination
I5S86_25935	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I5S86_25950	COG2982	Protein involved in outer membrane biogenesis
I5S86_25975	COG4221	oxidoreductase activity
I5S86_26005	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I5S86_26010	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I5S86_26020	COG1032	radical SAM domain protein
I5S86_26025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I5S86_26030	COG0305	Participates in initiation and elongation during chromosome replication
I5S86_26035	COG0359	binds to the 23S rRNA
I5S86_26045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I5S86_26050	COG0360	Binds together with S18 to 16S ribosomal RNA
I5S86_26055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5S86_26060	COG0557	exoribonuclease II activity
I5S86_26075	COG1840	ABC-type Fe3 transport system, periplasmic component
I5S86_26080	COG1178	ABC-type Fe3 transport system permease component
I5S86_26100	COG0840	transmembrane signaling receptor activity
I5S86_26105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I5S86_26110	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I5S86_26115	COG0330	HflC and HflK could
I5S86_26120	COG0330	HflC and HflK could
I5S86_26125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5S86_26130	COG1923	regulation of RNA biosynthetic process
I5S86_26135	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I5S86_26140	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I5S86_26145	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5S86_26150	COG0802	atpase or kinase
I5S86_26155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I5S86_26155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I5S86_26165	COG2860	membrane
I5S86_26170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I5S86_26175	COG1162	GTPase activity
I5S86_26205	COG0688	phosphatidylethanolamine metabolic process
I5S86_26210	COG0560	Phosphoserine phosphatase
I5S86_26210	COG3830	Belongs to the UPF0237 family
I5S86_26230	COG3577	Aspartyl protease
I5S86_26245	COG3150	esterase
I5S86_26250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5S86_26260	COG0494	nUDIX hydrolase
I5S86_26275	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I5S86_26280	COG1538	Outer membrane efflux protein
I5S86_26285	COG1773	rubredoxin
I5S86_26300	COG0475	glutathione-regulated potassium exporter activity
I5S86_26335	COG0629	single-stranded DNA binding
I5S86_26340	COG2814	Major facilitator Superfamily
I5S86_26345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I5S86_26350	COG2193	ferroxidase activity
I5S86_26355	COG0753	catalase activity
I5S86_26360	COG0203	ribosomal protein L17
I5S86_26365	COG0202	RNA polymerase activity
I5S86_26370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I5S86_26375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I5S86_26380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I5S86_26385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I5S86_26395	COG0200	Binds to the 23S rRNA
I5S86_26400	COG1841	ribosomal large subunit assembly
I5S86_26405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I5S86_26410	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I5S86_26415	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I5S86_26420	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I5S86_26425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I5S86_26430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I5S86_26435	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I5S86_26440	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I5S86_26445	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I5S86_26450	COG0255	Belongs to the universal ribosomal protein uL29 family
I5S86_26455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I5S86_26460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I5S86_26465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I5S86_26470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I5S86_26475	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I5S86_26480	COG0089	rRNA binding
I5S86_26485	COG0088	Forms part of the polypeptide exit tunnel
I5S86_26490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I5S86_26495	COG0051	transcription antitermination factor activity, RNA binding
I5S86_26500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I5S86_26505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5S86_26510	COG0049	tRNA binding
I5S86_26515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I5S86_26520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I5S86_26525	COG0085	RNA polymerase activity
I5S86_26535	COG0222	ribosome binding
I5S86_26540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I5S86_26545	COG0081	regulation of translation
I5S86_26550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I5S86_26570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I5S86_26595	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I5S86_26600	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I5S86_26600	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I5S86_26620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I5S86_26625	COG0739	heme binding
I5S86_26630	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I5S86_26635	COG0316	Belongs to the HesB IscA family
I5S86_26640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I5S86_26645	COG1981	membrane
I5S86_26650	COG2070	2-Nitropropane dioxygenase
I5S86_26655	COG0300	oxidoreductase activity
I5S86_26660	COG0537	adenosine 5'-monophosphoramidase activity
I5S86_26665	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I5S86_26675	COG1765	OsmC-like protein
I5S86_26690	COG0134	indole-3-glycerol-phosphate synthase activity
I5S86_26695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5S86_26700	COG0512	Glutamine amidotransferase of anthranilate synthase
I5S86_26705	COG4625	pathogenesis
I5S86_26705	COG3240	lipase activity
I5S86_26710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5S86_26715	COG0546	phosphoglycolate phosphatase activity
I5S86_26720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5S86_26725	COG1177	transmembrane transport
I5S86_26730	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5S86_26740	COG3842	ATPase activity
I5S86_26745	COG2197	response regulator
I5S86_26760	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I5S86_26765	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I5S86_26770	COG3178	'Phosphotransferase
I5S86_26775	COG3344	reverse transcriptase
I5S86_26780	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I5S86_26785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5S86_26790	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I5S86_26795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I5S86_26800	COG2967	ApaG domain
I5S86_26805	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5S86_26810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5S86_26815	COG2766	serine protein kinase
I5S86_26820	COG2718	Belongs to the UPF0229 family
I5S86_26825	COG2719	SpoVR family
I5S86_26830	COG0617	tRNA 3'-terminal CCA addition
I5S86_26835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5S86_26840	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5S86_26845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I5S86_26850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I5S86_26855	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I5S86_26860	COG0358	DNA primase activity
I5S86_26895	COG1484	DNA-dependent DNA replication
I5S86_26930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5S86_26935	COG1025	Belongs to the peptidase M16 family
I5S86_26945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5S86_26950	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I5S86_26960	COG0535	radical SAM domain protein
I5S86_26975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5S86_26980	COG0583	DNA-binding transcription factor activity
I5S86_26985	COG1960	acyl-CoA dehydrogenase activity
I5S86_26990	COG3706	GGDEF domain
I5S86_26995	COG1960	acyl-CoA dehydrogenase activity
I5S86_27015	COG1073	alpha beta
I5S86_27015	COG2226	methyltransferase
I5S86_27020	COG0156	8-amino-7-oxononanoate synthase activity
I5S86_27025	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I5S86_27030	COG1040	competence protein
I5S86_27035	COG3585	molybdate ion transport
I5S86_27035	COG2005	Transcriptional regulator
I5S86_27040	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5S86_27055	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5S86_27060	COG2204	response regulator
I5S86_27070	COG2176	DNA-directed DNA polymerase activity
I5S86_27075	COG1595	DNA-templated transcription, initiation
I5S86_27080	COG3712	iron ion homeostasis
I5S86_27085	COG4774	siderophore transport
I5S86_27125	COG0438	transferase activity, transferring glycosyl groups
I5S86_27140	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I5S86_27160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5S86_27170	COG4452	Inner membrane protein CreD
I5S86_27175	COG2205	protein histidine kinase activity
I5S86_27180	COG0745	RESPONSE REGULATOR receiver
I5S86_27190	COG0204	Acyl-transferase
I5S86_27220	COG1063	alcohol dehydrogenase
I5S86_27250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I5S86_27260	COG0840	transmembrane signaling receptor activity
I5S86_27280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5S86_27280	COG1017	nitric oxide dioxygenase activity
I5S86_27290	COG4638	Rieske (2fe-2S)
I5S86_27305	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I5S86_27310	COG0247	lactate metabolic process
I5S86_27310	COG2181	nitrate reductase activity
I5S86_27315	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5S86_27315	COG1902	pentaerythritol trinitrate reductase activity
I5S86_27355	COG3246	L-lysine catabolic process to acetate
I5S86_27360	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5S86_27385	COG1760	l-serine dehydratase
I5S86_27395	COG4176	ABC-type proline glycine betaine transport system permease component
I5S86_27400	COG4175	Glycine betaine
I5S86_27400	COG3448	diguanylate cyclase activity
I5S86_27405	COG0107	imidazoleglycerol-phosphate synthase activity
I5S86_27410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I5S86_27420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I5S86_27425	COG0131	Imidazoleglycerol-phosphate dehydratase
I5S86_27430	COG2223	nitrite transmembrane transporter activity
I5S86_27445	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I5S86_27480	COG4215	(ABC) transporter
I5S86_27525	COG0582	viral genome integration into host DNA
I5S86_27555	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I5S86_27565	COG0069	glutamate synthase activity
I5S86_27585	COG2957	Belongs to the agmatine deiminase family
I5S86_27590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5S86_27620	COG1218	3'(2'),5'-bisphosphate nucleotidase
I5S86_27625	COG0494	nUDIX hydrolase
I5S86_27630	COG1011	Hydrolase
I5S86_27635	COG1652	LysM domain
I5S86_27640	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I5S86_27645	COG0243	molybdopterin cofactor binding
I5S86_27670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I5S86_27675	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I5S86_27685	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5S86_27690	COG0189	ligase activity
I5S86_27690	COG4067	protein conserved in archaea
I5S86_27695	COG0189	ligase activity
I5S86_27710	COG2183	response to ionizing radiation
I5S86_27720	COG2918	glutathione biosynthetic process
I5S86_27735	COG1116	anion transmembrane transporter activity
I5S86_27740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5S86_27745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5S86_27750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5S86_27755	COG0450	alkyl hydroperoxide reductase
I5S86_27765	COG4521	taurine ABC transporter
I5S86_27770	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I5S86_27775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5S86_27780	COG2175	clavaminate synthase activity
I5S86_27785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5S86_27790	COG1045	serine acetyltransferase
I5S86_27795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_27800	COG0765	amino acid transport
I5S86_27805	COG1126	abc transporter atp-binding protein
I5S86_27820	COG2199	diguanylate cyclase activity
I5S86_27830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5S86_27835	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_27840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5S86_27850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5S86_27850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5S86_27855	COG0509	glycine decarboxylation via glycine cleavage system
I5S86_27860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I5S86_27865	COG1178	ABC-type Fe3 transport system permease component
I5S86_27875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5S86_27885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5S86_27890	COG0006	proline dipeptidase activity
I5S86_27895	COG3079	Belongs to the UPF0149 family
I5S86_27915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5S86_27950	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I5S86_27965	COG0248	Ppx GppA phosphatase
I5S86_27970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I5S86_27985	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I5S86_27990	COG1671	Belongs to the UPF0178 family
I5S86_28015	COG1566	PFAM secretion protein HlyD family protein
I5S86_28025	COG1289	transmembrane transporter activity
I5S86_28045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5S86_28060	COG2175	clavaminate synthase activity
I5S86_28145	COG1045	serine acetyltransferase
I5S86_28160	COG2610	gluconate transmembrane transporter activity
I5S86_28170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I5S86_28175	COG3048	D-serine ammonia-lyase activity
I5S86_28195	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_28220	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_28260	COG4974	Belongs to the 'phage' integrase family
I5S86_28340	COG1110	DNA topoisomerase II activity
I5S86_28460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5S86_28560	COG1192	Involved in chromosome partitioning
I5S86_28565	COG1475	DNA binding
I5S86_28690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5S86_28705	COG2203	Gaf domain
I5S86_28705	COG3706	GGDEF domain
I5S86_28705	COG5001	Diguanylate cyclase
I5S86_28705	COG4251	negative regulation of phosphorylation
I5S86_28760	COG0305	Participates in initiation and elongation during chromosome replication
I5S86_28825	COG2974	May be involved in recombination