locus-tag class description RA13_00025 ENOG4107SQ8 Glycine betaine RA13_00035 ENOG41079KZ Major Facilitator Superfamily RA13_00045 ENOG4108TTB tellurium resistance protein RA13_00065 ENOG4107TS3 membrane protein, TerC RA13_00070 ENOG4106FN3 tellurium resistance protein RA13_00075 ENOG4106FN3 tellurium resistance protein RA13_00080 ENOG4108N0M stress protein RA13_00085 ENOG4105DEN Luciferase family RA13_00095 ENOG4105DIK (ABC) transporter RA13_00100 ENOG4105DSE periplasmic solute binding protein RA13_00110 ENOG4105H9W Short-chain dehydrogenase reductase Sdr RA13_00130 ENOG4105G5W regulator Fur family RA13_00145 ENOG4107SET aldo keto reductase RA13_00150 ENOG41060AI SEC-C motif RA13_00155 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold RA13_00160 ENOG4107RB3 L-asparaginase RA13_00165 ENOG4105J7D transcriptional regulator RA13_00170 ENOG4105C0R drug resistance transporter emrb qaca subfamily RA13_00175 ENOG4107EPV Aminotransferase class V RA13_00180 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) RA13_00185 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) RA13_00190 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) RA13_00195 ENOG4105DGI Alkaline phosphatase RA13_00235 ENOG4105DPZ Two component transcriptional regulator (Winged helix family RA13_00255 ENOG4105CTX dehydratase RA13_00260 ENOG41073TP transcriptional regulator RA13_00265 ENOG4105EQX glucarate dehydratase RA13_00270 ENOG4105DJB Major Facilitator Superfamily RA13_00275 ENOG4105C26 Dehydrogenase RA13_00280 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase RA13_00295 ENOG4105CSV Glutaminase RA13_00305 ENOG4108J5H Homocysteine s-methyltransferase RA13_00315 ENOG4105CM2 brancheD-chain amino acid aminotransferase RA13_00325 ENOG4108X79 transcriptional regulator RA13_00330 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) RA13_00335 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane RA13_00335 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane RA13_00345 ENOG4105C72 UPF0176 protein RA13_00360 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin RA13_00380 ENOG4107ZTW SNARE associated Golgi RA13_00385 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase RA13_00400 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR RA13_00405 ENOG4107SCQ Iron-containing alcohol dehydrogenase RA13_00410 ENOG410631K Membrane RA13_00440 ENOG4107SJB teichoic acid biosynthesis RA13_00450 ENOG4107VDP teichoic acid biosynthesis RA13_00455 ENOG4107VDP teichoic acid biosynthesis RA13_00465 ENOG4105CXY transporter RA13_00470 ENOG4107VXM glycerophosphoryl diester phosphodiesterase RA13_00485 ENOG4107E6A Cytochrome p-450 RA13_00490 ENOG4108HWY Beta-lactamase RA13_00500 ENOG4106DDH Sporulation-specific SASP protein RA13_00510 ENOG41061AU MarR family Transcriptional regulator RA13_00520 ENOG41067MG lrgb family RA13_00545 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) RA13_00555 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family RA13_00565 ENOG4105DY8 decarboxylase RA13_00620 ENOG4105WAB arsR family transcriptional regulator RA13_00625 ENOG4105GPN Uncharacterized conserved protein (DUF2294) RA13_00655 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) RA13_00660 ENOG4107U5W ybbr family RA13_00665 ENOG4105C8B TIGR00159 family RA13_00675 ENOG4105EMN RNA polymerase sigma factor RA13_00705 ENOG4105EWC Purine nucleoside phosphorylase RA13_00715 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate RA13_00735 ENOG4105D17 glycoside hydrolase, family 3 domain protein RA13_00740 ENOG4105EHZ conserved protein UCP016719 RA13_00745 ENOG410874W AraC family transcriptional regulator RA13_00765 ENOG4108SA1 esterase RA13_00775 ENOG4105CHH sulfate transporter RA13_00790 ENOG4108JPW Aminotransferase RA13_00825 ENOG4108NMV polysaccharide deacetylase RA13_00840 ENOG4105D1F ATP-binding protein RA13_00865 ENOG4108I0C methyltransferase RA13_00875 ENOG4108UJD 30S ribosomal protein S9 RA13_00880 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) RA13_00885 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) RA13_00890 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) RA13_00895 ENOG4108JJB ABC transporter RA13_00900 ENOG4108JJB ABC transporter RA13_00905 ENOG4108ZT0 50S ribosomal protein l17 RA13_00910 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) RA13_00915 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) RA13_00920 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits RA13_00930 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) RA13_00940 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) RA13_00945 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) RA13_00950 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) RA13_00960 ENOG4105VPB 50S ribosomal protein L30 RA13_00965 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) RA13_00970 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) RA13_00975 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) RA13_00980 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) RA13_00990 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits RA13_01005 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RA13_01010 ENOG41082SA 50s ribosomal protein l29 RA13_01015 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) RA13_01020 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) RA13_01025 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) RA13_01030 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) RA13_01035 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity RA13_01040 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) RA13_01045 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) RA13_01050 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) RA13_01055 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) RA13_01060 ENOG4107SKW Inherit from COG: Alpha beta hydrolase RA13_01065 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) RA13_01070 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) RA13_01075 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) RA13_01085 ENOG4105XPM ribosomal protein RA13_01090 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) RA13_01095 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) RA13_01100 ENOG4107Y49 methyltransferase RA13_01105 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) RA13_01110 ENOG4108VZM 50s ribosomal protein L10 RA13_01120 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) RA13_01125 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) RA13_01145 ENOG4105M0M Tetracycline resistance protein RA13_01150 ENOG4105C2N RNA methyltransferase TrmH family group 3 RA13_01155 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) RA13_01160 ENOG4105C8N cysteinyl-tRNA synthetase RA13_01170 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) RA13_01175 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) RA13_01180 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) RA13_01185 ENOG4105CTP PilT protein domain protein RA13_01190 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) RA13_01195 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) RA13_01205 ENOG41066A3 ATP guanido phosphotransferase RA13_01210 ENOG4108Z0C Uvrb UvrC protein RA13_01295 ENOG4105CRK lysyL-tRNA synthetase RA13_01300 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) RA13_01310 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase RA13_01315 ENOG4105KRF dihydroneopterin aldolase RA13_01320 ENOG4105EEI dihydropteroate synthase RA13_01325 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 RA13_01330 ENOG4105DDQ anthranilate synthase RA13_01335 ENOG4105CRQ synthase (Component I) RA13_01340 ENOG4105C6T cysteine synthase RA13_01345 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase RA13_01350 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) RA13_01355 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) RA13_01360 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) RA13_01365 ENOG4108UGV hypoxanthine phosphoribosyltransferase RA13_01370 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) RA13_01400 ENOG41060GV RNA binding s1 domain protein RA13_01415 ENOG4105VYY sporulation protein yabp RA13_01420 ENOG41082I2 s4 domain protein RA13_01425 ENOG4108IY2 MazG family RA13_01435 ENOG4108M14 stage v sporulation protein t RA13_01440 ENOG4108JA2 transcriptioN-repair coupling factor RA13_01455 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) RA13_01460 ENOG4105C5T Phosphoribosyl pyrophosphate synthase RA13_01465 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) RA13_01470 ENOG4105K4W Could be involved in septation (By similarity) RA13_01475 ENOG4105KME endoribonuclease L-psp RA13_01480 ENOG4105DFT pur operon repressor RA13_01485 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) RA13_01490 ENOG4105XEW small acid-soluble spore protein RA13_01495 ENOG4105W42 Veg protein RA13_01500 ENOG4105XFA sporulation peptidase YabG RA13_01505 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) RA13_01515 ENOG41069ER domain protein RA13_01525 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) RA13_01530 ENOG4105KRN Transcriptional regulator, abrb family RA13_01535 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) RA13_01540 ENOG4105VC4 domain protein RA13_01545 ENOG41060K3 Methyltransferase RA13_01555 ENOG4105MA4 psp1 domain protein RA13_01560 ENOG4105FA2 dna polymerase iii RA13_01565 ENOG4105XVJ Protein of unknown function (DUF327) RA13_01570 ENOG4105X0R protein from nitrogen regulatory protein P-II RA13_01575 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) RA13_01585 ENOG4105CDW Resistance protein RA13_01625 ENOG41067KS pro-sigma K processing RA13_01635 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) RA13_01640 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) RA13_01645 ENOG4105C6E dna polymerase iii RA13_01655 ENOG4108Z6B deaminase RA13_01660 ENOG4105GTG Isochorismatase RA13_01665 ENOG4105VRS hydrolase family 18 RA13_01675 ENOG4105ZMH deoxynucleoside kinase RA13_01685 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) RA13_01690 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) RA13_01695 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) RA13_01705 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) RA13_01775 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) RA13_01780 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) RA13_01795 ENOG410848D S4 domain protein YaaA RA13_01800 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) RA13_01805 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) RA13_01815 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) RA13_01830 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) RA13_01835 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) RA13_01855 ENOG4107QJE Chromosome Partitioning Protein RA13_01860 ENOG4105FA0 parb-like partition protein RA13_01865 ENOG4108ZDA Sporulation protein YyaC RA13_01875 ENOG4105VDK protein, conserved in bacteria RA13_01880 ENOG4108J2R molybdopterin oxidoreductase RA13_01885 ENOG4105C3G gtp-binding protein RA13_01890 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) RA13_01895 ENOG4108UUM single-stranded DNA-binding protein RA13_01900 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) RA13_01910 ENOG4108WYP Transcriptional regulator RA13_01915 ENOG4108UZ3 Transporter RA13_01920 ENOG4105CGK Exodeoxyribonuclease III RA13_01940 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase RA13_01950 ENOG4105C7Z Conserved Protein RA13_01960 ENOG41068WC Domain of unknown function (DUF955) RA13_01980 ENOG4105DPZ Two component transcriptional regulator (Winged helix family RA13_02000 ENOG4105ENE Histidine kinase RA13_02005 ENOG4108VB1 regulatoR RA13_02010 ENOG4105EYF MMPL domain protein RA13_02020 ENOG41090E6 transcriptional regulator MERR family RA13_02025 ENOG4105DRR Transcriptional regulator, GntR family RA13_02030 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) RA13_02040 ENOG4105VMI -acetyltransferase RA13_02055 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase RA13_02060 ENOG4105KVH Transcriptional regulator RA13_02075 ENOG4108XMW Membrane RA13_02080 ENOG4105BZR domain protein RA13_02085 ENOG4105K9Q Binds to the 23S rRNA (By similarity) RA13_02090 ENOG4105EDW glycosyl transferase, family 39 RA13_02095 ENOG4105DJ2 Major Facilitator Superfamily RA13_02115 ENOG4105CDU Replicative dna helicase RA13_02120 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase RA13_02150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family RA13_02155 ENOG4105BZU Histidine kinase RA13_02170 ENOG4105Q2H domain protein RA13_02175 ENOG4105C0H protease RA13_02195 ENOG4105C5H ABC transporter RA13_02205 ENOG4108JUB Transcriptional regulator RA13_02210 ENOG41082BM Transcriptional regulator, arsr family RA13_02220 ENOG4105C8Y Acetylornithine aminotransferase RA13_02225 ENOG4108IQI permease RA13_02230 ENOG41066UZ arginase EC 3.5.3.1 RA13_02235 ENOG4105WQG acetyltransferase RA13_02240 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) RA13_02255 ENOG4105E2A Dehydrogenase RA13_02265 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) RA13_02295 ENOG4105W5Q DNA repair protein (RadC RA13_02360 ENOG410900G Protein of unknown function (DUF421) RA13_02365 ENOG4107R4J Chloride channel RA13_02370 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 RA13_02375 ENOG4108Z15 abc transporter atp-binding protein RA13_02380 ENOG4106KKU RA13_02395 ENOG4105C85 amino acid RA13_02405 ENOG4108JU3 Alkyl hydroperoxide reductase RA13_02410 ENOG4105D3R alkyl hydroperoxide reductase RA13_02425 ENOG4105C6Z Gluconate RA13_02430 ENOG4105CMG Carbohydrate kinase RA13_02435 ENOG4105G3Z GntR family transcriptional regulator RA13_02440 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR RA13_02445 ENOG4107QQ0 gntp family RA13_02450 ENOG4105BZW Glycerate kinase RA13_02490 ENOG4105J7D transcriptional regulator RA13_02505 ENOG41085PJ rdd domain containing protein RA13_02515 ENOG4105C26 Dehydrogenase RA13_02520 ENOG4105ST3 Transcriptional regulator RA13_02525 ENOG41061TZ Short-chain dehydrogenase reductase Sdr RA13_02530 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) RA13_02535 ENOG4107QNK )-transporter RA13_02555 ENOG4105CPC Aldo Keto reductase RA13_02565 ENOG4105C26 Dehydrogenase RA13_02575 ENOG4105D7K pfkb domain protein RA13_02580 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) RA13_02585 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) RA13_02595 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) RA13_02600 ENOG4105F0H myo-inositol catabolism protein RA13_02605 ENOG4105WZ4 isomerase RA13_02615 ENOG4108V5C ABC transporter RA13_02670 ENOG410667J hydrolase RA13_02675 ENOG4107QHE Choloylglycine hydrolase RA13_02685 ENOG4105ENY Ethanolamine utilization protein eutH RA13_02690 ENOG4108TM9 integral membrane protein RA13_02695 ENOG4107RHR regulatoR RA13_02705 ENOG4105D9N nucleoside RA13_02710 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) RA13_02720 ENOG4107W25 arginase agmatinase formiminoglutamase RA13_02725 ENOG4105CI2 imidazolone-5-propionate hydrolase RA13_02730 ENOG4105CGP Urocanate hydratase RA13_02735 ENOG4105C84 Histidine ammonia-lyase RA13_02795 ENOG4106Z5D Glycoside Hydrolase Family 43 RA13_02805 ENOG4105CPF Cell wall formation (By similarity) RA13_02820 ENOG4105JKW Valine--pyruvate aminotransferase RA13_02825 ENOG4105C5Y PTS System RA13_02830 ENOG4105CS2 ec 3.2.1.21 RA13_02835 ENOG4107YZX Universal stress protein RA13_02945 ENOG4107TDE lipolytic protein G-D-S-L family RA13_02950 ENOG4105DDN Pentapeptide repeat-containing protein RA13_02960 ENOG4105C1J atp-dependent rna helicase RA13_02965 ENOG4105DEU major facilitator superfamily RA13_02975 ENOG4105CID antiterminator RA13_02985 ENOG4105D4T Citrate transporter RA13_02990 ENOG4105CH6 catalase RA13_03010 ENOG4105DHI Methyltransferase RA13_03015 ENOG4105CY2 Citrate transporter RA13_03020 ENOG4105D6N CoA-transferase, subunit a RA13_03025 ENOG4108IIH CoA-transferase subunit B RA13_03030 ENOG4105DTD Dehydrogenase RA13_03035 ENOG4108JUB Transcriptional regulator RA13_03060 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) RA13_03070 ENOG4105CMR udp-glucose 4-epimerase RA13_03080 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) RA13_03100 ENOG4107BJW polysaccharide deacetylase RA13_03110 ENOG4105D2K citrate carrier protein RA13_03115 ENOG4105C4M (Ubiquinol oxidase) subunit I RA13_03120 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii RA13_03125 ENOG4108JJ9 ABC, transporter RA13_03130 ENOG4108JJ8 (ABC) transporter RA13_03135 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) RA13_03140 ENOG4105ETS cytosine purines uracil thiamine allantoin RA13_03160 ENOG41069JR RA13_03165 ENOG4105DA5 (ABC) transporter RA13_03180 ENOG4105CH6 catalase RA13_03185 ENOG4108VX5 3-methyladenine DNA glycosylase RA13_03190 ENOG4105EMD TRANSCRIPTIONal RA13_03195 ENOG4105VZJ PTS System RA13_03200 ENOG4105CK1 PTS System RA13_03205 ENOG4105VCP PTS System RA13_03210 ENOG4105F8D glycoside hydrolase family 4 RA13_03215 ENOG4105CM2 brancheD-chain amino acid aminotransferase RA13_03220 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD RA13_03225 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) RA13_03230 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein RA13_03235 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) RA13_03260 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) RA13_03265 ENOG4105GVJ transcriptional regulator RA13_03275 ENOG4105IIU Aminopeptidase RA13_03285 ENOG4105X1N Glycosyl transferase family 8 RA13_03310 ENOG4105CK1 PTS System RA13_03320 ENOG4105DR4 Methyltransferase RA13_03355 ENOG4108RDQ ABC transporter RA13_03360 ENOG41067MG lrgb family RA13_03365 ENOG4105VAW lrga family RA13_03370 ENOG4105CMU LysR family (Transcriptional regulator RA13_03380 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) RA13_03385 ENOG4107ZXU DSBA oxidoreductase RA13_03420 ENOG4105WH5 Teichoic acid glycosylation protein RA13_03425 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) RA13_03435 ENOG4107BMA Transglycosylase associated protein RA13_03440 ENOG4105E2S oxidase) subunit II RA13_03445 ENOG4105BZ9 Cytochrome C oxidase, subunit I RA13_03455 ENOG41060D1 Quinol oxidase RA13_03475 ENOG4108DBC nitroreductase RA13_03480 ENOG4105DEN Luciferase family RA13_03525 ENOG4105DWF phosphomethylpyrimidine kinase RA13_03545 ENOG4108RJ9 Glycosyl transferase, family 2 RA13_03550 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) RA13_03555 ENOG4105C26 Dehydrogenase RA13_03590 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD RA13_03595 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) RA13_03600 ENOG4105C1B dTDP-glucose 4-6-dehydratase RA13_03610 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase RA13_03620 ENOG4105C2C drug resistance transporter, Bcr CflA RA13_03625 ENOG4105FCW Major Facilitator superfamily RA13_03635 ENOG4108IJ2 phosphate acetyltransferase RA13_03640 ENOG4105HMI Membrane RA13_03645 ENOG4105DUM transcriptional regulator, lysR family RA13_03650 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) RA13_03655 ENOG4108RNG Permease of the drug metabolite transporter RA13_03660 ENOG4108VCI transcription factor, rsfa family RA13_03670 ENOG4105DCI Phosphohydrolase RA13_03680 ENOG4105CUB amino acid RA13_03685 ENOG41067TZ transcriptional regulator, MarR family RA13_03690 ENOG41069HH 4-oxalocrotonate tautomerase RA13_03695 ENOG4108Z4T Peptidase M50 RA13_03700 ENOG4108XFG YwhD family RA13_03705 ENOG4105BZ4 penicillin-binding protein RA13_03710 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) RA13_03715 ENOG4105CYW agmatinase RA13_03725 ENOG4108RDQ ABC transporter RA13_03755 ENOG4107JM4 Tetratricopeptide repeat RA13_03760 ENOG41090UD (LipO)protein RA13_03790 ENOG410684U Domain of unknown function (DUF1934) RA13_03795 ENOG4105C75 arginyL-tRNA synthetase RA13_03805 ENOG4107V6Q Cyclic nucleotide-binding domain RA13_03825 ENOG4108IUE nitrate reductase beta subunit RA13_03830 ENOG4105R3A Nitrate reductase RA13_03840 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) RA13_03845 ENOG4105BZ1 (ABC) transporter RA13_03850 ENOG4105NAE bifunctional deaminase-reductase domain protein RA13_03860 ENOG4105E5J UV damage endonuclease RA13_03870 ENOG4105DF6 Fe-S oxidoreductase RA13_03875 ENOG4105C1G acyl-Coa dehydrogenase RA13_03885 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) RA13_03895 ENOG410812K response regulator receiver protein RA13_03900 ENOG4105D2N Aldolase RA13_03910 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) RA13_03915 ENOG4105CBT Fructose-1,6-bisphosphatase RA13_03920 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) RA13_03925 ENOG41082DI 50s ribosomal protein l31 RA13_03930 ENOG4107104 thymidine kinase RA13_03935 ENOG4105C6K Malic enzyme RA13_03940 ENOG4107TT2 Auxin Efflux Carrier RA13_03950 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase RA13_03955 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) RA13_03960 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) RA13_03975 ENOG4108ZXQ stage ii sporulation protein r RA13_03985 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) RA13_03990 ENOG410815N Probably functions as a manganese efflux pump (By similarity) RA13_03995 ENOG4107WAU Protein tyrosine phosphatase RA13_04000 ENOG4108YZG isomerase RA13_04005 ENOG4108UIC UPF0340 protein RA13_04010 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) RA13_04015 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) RA13_04025 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) RA13_04045 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) RA13_04050 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) RA13_04055 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) RA13_04060 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) RA13_04070 ENOG4106778 Protein of unknown function (DUF1146) RA13_04080 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) RA13_04100 ENOG4108TF4 von Willebrand factor, type A RA13_04110 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) RA13_04115 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) RA13_04135 ENOG4108YZ9 Urea amidohydrolase subunit gamma RA13_04140 ENOG4105KI2 Urea amidohydrolase subunit beta RA13_04145 ENOG4105CQM Urea amidohydrolase subunit alpha RA13_04150 ENOG4108Z40 Transcriptional regulator RA13_04155 ENOG4108RYK Nad-dependent epimerase dehydratase RA13_04160 ENOG4106BRK RA13_04165 ENOG4107TXC Transcriptional regulator RA13_04170 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) RA13_04195 ENOG4107TY6 Acylneuraminate cytidylyltransferase RA13_04200 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase RA13_04205 ENOG4105C1B dTDP-glucose 4-6-dehydratase RA13_04210 ENOG4105C5E polysaccharide biosynthesis protein RA13_04220 ENOG4107TCE N-acetyltransferase RA13_04225 ENOG4105FRN stage II sporulation protein RA13_04235 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase RA13_04240 ENOG4105CNI cell division protein FtsW RA13_04250 ENOG4105BZU Histidine kinase RA13_04255 ENOG4107P26 RA13_04260 ENOG4105D3W isochorismatase RA13_04265 ENOG41080V3 Major Facilitator superfamily RA13_04270 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease RA13_04275 ENOG4105CZM Major Facilitator RA13_04280 ENOG4107MII Sugar-specific transcriptional regulator TrmB RA13_04290 ENOG4105MT0 Sporulation transcriptional regulator spoiiid RA13_04295 ENOG4105DFF Rod shape-determining protein mreb RA13_04305 ENOG4105CGA flagellar basal-body rod protein FlgG RA13_04315 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) RA13_04320 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) RA13_04335 ENOG4105Z8H single-stranded DNA-binding protein RA13_04340 ENOG4105E98 transcriptional regulator DeoR family RA13_04345 ENOG410667J hydrolase RA13_04350 ENOG4105C0D helicase RA13_04355 ENOG4105KBK Zinc finger, swim domain protein RA13_04365 ENOG4105HTX biosynthesis protein RA13_04370 ENOG4107YJ4 chain length determinant protein RA13_04375 ENOG4108RB3 Capsular polysaccharide biosynthesis protein RA13_04380 ENOG4105C6Y Udp-glucose 6-dehydrogenase RA13_04405 ENOG4106YAD MORN repeat variant RA13_04415 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) RA13_04435 ENOG4107V2S Transcriptional regulator RA13_04440 ENOG4108WS4 fmn reductase RA13_04450 ENOG4105FGV Chromate RA13_04455 ENOG4105CAH Chromate RA13_04465 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) RA13_04475 ENOG4105UP7 3-epimerase RA13_04490 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia RA13_04495 ENOG4107XC4 flavin reductase domain protein, FMN-binding RA13_04520 ENOG4107FQX Alpha-acetolactate decarboxylase RA13_04525 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein RA13_04540 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator RA13_04545 ENOG4105CNN ABC, transporter RA13_04550 ENOG4105C2J ABC transporter RA13_04555 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) RA13_04560 ENOG4108RVA ribokinase RA13_04565 ENOG4105ETE Transcriptional regulator (LacI family RA13_04575 ENOG4108Q8B Spore germination protein RA13_04585 ENOG4105N98 Capsule biosynthesis protein capB RA13_04595 ENOG4105PNM synthesis protein RA13_04605 ENOG4105K4H Nlp p60 protein RA13_04610 ENOG4105J7I hydrolase RA13_04615 ENOG4108KGH TRANSCRIPTIONal RA13_04620 ENOG4105C54 Major Facilitator superfamily RA13_04625 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) RA13_04630 ENOG4108NHD germination protein RA13_04645 ENOG4105DG6 mannose-6-phosphate isomerase RA13_04655 ENOG4107RZX Teichoic acid biosynthesis protein RA13_04665 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase RA13_04675 ENOG4107SJB teichoic acid biosynthesis RA13_04685 ENOG4105EY8 ABC transporter RA13_04690 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase RA13_04695 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase RA13_04710 ENOG4105JFG SpoIID LytB domain protein RA13_04715 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase RA13_04725 ENOG4105D3Q Sugar transferase RA13_04735 ENOG4107RA4 Glycosyl transferase (Group 1 RA13_04740 ENOG4105C6Y Udp-glucose 6-dehydrogenase RA13_04745 ENOG4105QZI O-Antigen Polymerase RA13_04760 ENOG4107EF8 Glycosyl transferase (Group 1 RA13_04765 ENOG4105ESV Glycosyl transferase, family 4 RA13_04770 ENOG4108KGH TRANSCRIPTIONal RA13_04775 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein RA13_04780 ENOG4105BZU Histidine kinase RA13_04785 ENOG4105WH1 Two component transcriptional regulator luxr family RA13_04805 ENOG41081UC Inherit from COG: Competence protein RA13_04810 ENOG4105RU3 RA13_04825 ENOG4105E1Q flagellar hook-associated protein RA13_04830 ENOG4105DTJ flagellar hook-associated protein RA13_04835 ENOG4105MKD RA13_04840 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) RA13_04845 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) RA13_04850 ENOG4105I03 Flagellin RA13_04855 ENOG41083S7 flagellar protein FlaG RA13_04860 ENOG4107RT6 flagellar hook-associated RA13_04865 ENOG4105MQ3 flagellar protein FliS RA13_04880 ENOG4105MS2 ribosomal subunit Interface protein RA13_04905 ENOG4105CAK Cell division ATP-binding protein ftsE RA13_04910 ENOG4105CRP Part of the ABC transporter FtsEX involved in RA13_04915 ENOG4105CN1 protease RA13_04940 ENOG4105MKU Transcriptional regulator RA13_04960 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) RA13_04975 ENOG4108PY7 RA13_04980 ENOG41067S9 phage shock protein C, PspC RA13_04985 ENOG41086DT Membrane protein of unknown function RA13_04990 ENOG41088CQ domain protein RA13_04995 ENOG4105FDP GntR family transcriptional regulator RA13_05000 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) RA13_05005 ENOG4105CE4 GlcNAc 6-P deacetylase RA13_05010 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) RA13_05015 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) RA13_05020 ENOG4105HKU nucleoside recognition domain-containing protein RA13_05025 ENOG4107XGZ Hydrolase RA13_05030 ENOG4108S4C acetyltransferase RA13_05035 ENOG4108E16 pectate lyase RA13_05050 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) RA13_05055 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) RA13_05060 ENOG4105ECC imidazole-glycerol-phosphate dehydratase RA13_05065 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) RA13_05070 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase RA13_05075 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) RA13_05080 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase RA13_05085 ENOG4105VRR gCN5-related N-acetyltransferase RA13_05115 ENOG4105C3M thioredoxin reductase RA13_05120 ENOG4108Z4K mutator MutT protein RA13_05125 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) RA13_05130 ENOG4105CHW UPF0052 protein RA13_05135 ENOG4105CIE May be required for sporulation (By similarity) RA13_05140 ENOG4105KRI phosphocarrier protein (HPr RA13_05145 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase RA13_05150 ENOG4105GGE ribonuclease RA13_05160 ENOG4105EWM Histidine kinase RA13_05165 ENOG4105C19 ABC transporter RA13_05175 ENOG4105C5I Dehydrogenase RA13_05185 ENOG4105CHH sulfate transporter RA13_05190 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain RA13_05195 ENOG4108URH decarboxylase RA13_05205 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) RA13_05220 ENOG4108MK9 spermidine N(1)-acetyltransferase RA13_05250 ENOG4105EDQ levansucrase EC 2.4.1.10 RA13_05270 ENOG4105CJ1 ABC, transporter RA13_05285 ENOG4105EBR Carboxylesterase RA13_05295 ENOG4105HTX biosynthesis protein RA13_05300 ENOG4108QV3 biosynthesis protein RA13_05310 ENOG4108PQP glycosyl transferase group 1 RA13_05315 ENOG4105K64 Glycosyl transferase, family 2 RA13_05320 ENOG4108KMV Glycosyl transferase (Group 1 RA13_05325 ENOG41068W6 Capsular polysaccharide biosynthesis protein RA13_05330 ENOG4107QRS glycosyltransferase group 2 family protein RA13_05340 ENOG4105K64 Glycosyl transferase, family 2 RA13_05350 ENOG4105D3Q Sugar transferase RA13_05355 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family RA13_05360 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase RA13_05365 ENOG4108ZPC Polysaccharide pyruvyl transferase RA13_05375 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) RA13_05385 ENOG4105JXH GntR family transcriptional regulator RA13_05390 ENOG4108MJI response regulator RA13_05395 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) RA13_05400 ENOG4107QR9 Iron-sulfur cluster binding protein RA13_05405 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) RA13_05420 ENOG4107RT3 EamA-like transporter family RA13_05425 ENOG4105GZI Transcriptional regulator RA13_05430 ENOG4105DEN Luciferase family RA13_05435 ENOG4105CMD Transcriptional regulator, GntR family RA13_05450 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase RA13_05455 ENOG4105BZA Phosphoglycerate kinase RA13_05460 ENOG4105CP7 Triose-phosphate isomerase RA13_05465 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) RA13_05470 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) RA13_05475 ENOG4105IIU Aminopeptidase RA13_05480 ENOG4107QQG Dehydrogenase RA13_05485 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase RA13_05490 ENOG4108IAJ Nad-dependent epimerase dehydratase RA13_05495 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase RA13_05510 ENOG4105FJR Lmbe family RA13_05525 ENOG4108W0I acetyltransferase RA13_05530 ENOG4105T65 Membrane-associated protein RA13_05545 ENOG4107HG4 Transcriptional regulator RA13_05550 ENOG4108IJ8 ABC transporter RA13_05555 ENOG4105E90 ABC transporter RA13_05560 ENOG4108HQR Glycine betaine RA13_05565 ENOG4105R40 Glycine betaine carnitine choline RA13_05570 ENOG4107HG4 Transcriptional regulator RA13_05575 ENOG4108IJ8 ABC transporter RA13_05585 ENOG4108HQR Glycine betaine RA13_05590 ENOG4105R40 Glycine betaine carnitine choline RA13_05595 ENOG4105C8Q Methyl-accepting chemotaxis RA13_05600 ENOG4105KVH Transcriptional regulator RA13_05620 ENOG4105XZU Preprotein translocase, subunit SecG RA13_05630 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) RA13_05635 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) RA13_05645 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) RA13_05650 ENOG4105D9R oxidoreductase RA13_05655 ENOG4105VPX protein, conserved in bacteria RA13_05660 ENOG410681U heavy metal transport detoxification protein RA13_05665 ENOG4105C59 p-type ATPase RA13_05670 ENOG4105C59 p-type ATPase RA13_05675 ENOG4107ZQN disulfide bond RA13_05690 ENOG4105EN6 Membrane RA13_05695 ENOG4105EEM helicase RA13_05700 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) RA13_05705 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) RA13_05715 ENOG4105EEQ Na H antiporter RA13_05735 ENOG4105E0C molybdate abc transporter RA13_05740 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein RA13_05745 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family RA13_05750 ENOG4107QZ2 Sulfatase RA13_05755 ENOG4107K5X Membrane-bound metal-dependent hydrolase RA13_05770 ENOG4105D5Q Arginine ornithine antiporter RA13_05785 ENOG4105DQ5 transport system permease protein RA13_05790 ENOG4105EHG Permease protein RA13_05795 ENOG4105E0A ABC, transporter RA13_05800 ENOG4108WMK Efflux transporter RND family MFP subunit RA13_05805 ENOG4105C19 ABC transporter RA13_05810 ENOG4107RBB ABC transporter, permease RA13_05820 ENOG4105F0F Oxalate decarboxylase RA13_05830 ENOG4106DF4 Sigma-70, region 4 RA13_05840 ENOG4105DPZ Two component transcriptional regulator (Winged helix family RA13_05850 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein RA13_05855 ENOG4105EWI Short-chain dehydrogenase reductase Sdr RA13_05860 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) RA13_05865 ENOG4105EHG Permease protein RA13_05870 ENOG4105E0A ABC, transporter RA13_05875 ENOG4108WBT adenosyltransferase RA13_05890 ENOG41087YS Phage shock protein A RA13_05905 ENOG4105ENE Histidine kinase RA13_05910 ENOG4105WH1 Two component transcriptional regulator luxr family RA13_05935 ENOG4105C9Q fumarate hydratase class II RA13_05940 ENOG41067SE Tetr family transcriptional regulator RA13_05950 ENOG4105F3H Histidine kinase RA13_05960 ENOG4105C0H protease RA13_05965 ENOG4105HUF DNA protection during starvation protein RA13_05970 ENOG4105E1F short-chain dehydrogenase reductase RA13_05985 ENOG4105E0A ABC, transporter RA13_05995 ENOG4105C0R drug resistance transporter emrb qaca subfamily RA13_06000 ENOG41067TZ transcriptional regulator, MarR family RA13_06030 ENOG4105CHU acetyl-coa acetyltransferase RA13_06035 ENOG4105C1G acyl-Coa dehydrogenase RA13_06040 ENOG41080E8 Transcriptional regulator, Spx MgsR family RA13_06045 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) RA13_06070 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) RA13_06075 ENOG4108UMI ABC transporter, permease RA13_06080 ENOG4105D01 (LipO)protein RA13_06090 ENOG4105C3K feS assembly ATPase SufC RA13_06095 ENOG4105JRK feS assembly protein SufD RA13_06100 ENOG4105C9B Cysteine desulfurase RA13_06105 ENOG4108UNV SUF system FeS assembly protein, NifU family RA13_06110 ENOG4105DIW FeS assembly protein SUFB RA13_06115 ENOG4107VFR oxidoreductase RA13_06120 ENOG4105PKS Excinuclease abc c subunit domain protein RA13_06125 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine RA13_06130 ENOG4105XN3 extracellular solute-binding protein family 1 RA13_06135 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component RA13_06140 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component RA13_06145 ENOG4108KPW sugar kinase RA13_06150 ENOG4105FDP GntR family transcriptional regulator RA13_06155 ENOG4108IJ9 (ABC) transporter RA13_06165 ENOG4108K8S endonuclease I RA13_06170 ENOG4108I0Q anthranilate phosphoribosyltransferase RA13_06180 ENOG4105C5R Aminotransferase RA13_06210 ENOG4105CJ1 ABC, transporter RA13_06265 ENOG4105EMN RNA polymerase sigma factor RA13_06275 ENOG4105G9B Transcriptional regulator RA13_06280 ENOG4105CD3 dihydroorotase RA13_06295 ENOG4105I3N Conserved Protein RA13_06305 ENOG4107R8B 5'-nucleotidase RA13_06310 ENOG4105KZD Domain of unknown function (DUF1805) RA13_06315 ENOG4108YTE sporulation protein YunB RA13_06320 ENOG4105FAA peptidase M23 RA13_06325 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) RA13_06330 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) RA13_06335 ENOG4105MMD transcriptional regulator RA13_06345 ENOG4105D4U had-superfamily hydrolase, subfamily iia RA13_06350 ENOG4108W5N phosphatidylglycerophosphatase a RA13_06360 ENOG4105D6E homoserine dehydrogenase RA13_06365 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) RA13_06370 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) RA13_06375 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein RA13_06380 ENOG41083MR nifu domain-containing protein RA13_06390 ENOG4105PY6 Phenolic acid decarboxylase RA13_06400 ENOG4105ZKE UPF0349 protein RA13_06415 ENOG4108YX9 iron--sulfur cluster insertion protein erpA RA13_06435 ENOG4105CEP NADH dehydrogenase RA13_06450 ENOG41069ER domain protein RA13_06460 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) RA13_06490 ENOG4105NIV Esterase RA13_06495 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase RA13_06500 ENOG4105E4F Isochorismate synthase RA13_06510 ENOG4105WQI isochorismatase RA13_06515 ENOG4105CEY Amp-dependent synthetase and ligase RA13_06520 ENOG4105WQT MbtH domain protein RA13_06530 ENOG4105DCF alanine dehydrogenase RA13_06535 ENOG4108K8K Transcriptional regulator RA13_06570 ENOG410904N short-chain dehydrogenase reductase RA13_06585 ENOG4105C02 permease RA13_06610 ENOG4105DAP Nicotinate phosphoribosyltransferase RA13_06615 ENOG4105D58 Diguanylate phosphodiesterase RA13_06640 ENOG4105BZU Histidine kinase RA13_06650 ENOG4105KA0 thioesterase Superfamily protein RA13_06655 ENOG4105KJM monovalent cation h antiporter subunit g RA13_06665 ENOG4105SC1 monovalent cation H antiporter subunit E RA13_06670 ENOG4108JPZ Monovalent cation H antiporter subunit D RA13_06675 ENOG4108ZE9 Monovalent cation H antiporter subunit C RA13_06680 ENOG4105HC0 Na H antiporter RA13_06705 ENOG4105UIB (ABC) transporter RA13_06710 ENOG4108JQ9 ABC transporter RA13_06715 ENOG4105DIH basic membrane RA13_06720 ENOG4108MRH transcriptional regulatory protein RA13_06735 ENOG4105KIR Thiol-disulfide oxidoreductase dcc RA13_06740 ENOG4105BZ4 penicillin-binding protein RA13_06760 ENOG4105Y38 Kinase-associated protein B RA13_06765 ENOG4108HGU Histidine kinase RA13_06770 ENOG4105C87 Aminotransferase class I and II RA13_06780 ENOG4108MUZ hydrolase RA13_06785 ENOG4108ZB6 transcriptional regulator AsnC family RA13_06790 ENOG4105CHM Aminotransferase RA13_06800 ENOG4105WG9 Conserved Protein RA13_06805 ENOG4107QW4 alcohol dehydrogenase RA13_06815 ENOG4107QYV phosphohexose isomerase RA13_06830 ENOG4107PBV potassium channel RA13_06835 ENOG4107PBV potassium channel RA13_06850 ENOG4105C37 (CBS) domain RA13_06860 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme RA13_06865 ENOG4105EA8 2-Nitropropane dioxygenase RA13_06880 ENOG4105C8Q Methyl-accepting chemotaxis RA13_06885 ENOG4105C8Q Methyl-accepting chemotaxis RA13_06890 ENOG4105C8Q Methyl-accepting chemotaxis RA13_06895 ENOG4105C8Q Methyl-accepting chemotaxis RA13_06905 ENOG4105E98 transcriptional regulator DeoR family RA13_06910 ENOG4105DET Rhamnulokinase RA13_06915 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) RA13_06920 ENOG4105DKG l-rhamnose isomerase RA13_06925 ENOG4108Z0Z intracellular protease Pfpi family RA13_06930 ENOG4105EE0 oxidoreductase RA13_06995 ENOG41068SY RA13_07010 ENOG4107KNS RA13_07025 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj RA13_07035 ENOG4105CZN Potassium uptake protein RA13_07055 ENOG4105TRT Transcriptional regulator RA13_07060 ENOG4105C26 Dehydrogenase RA13_07065 ENOG4108JB8 alcohol dehydrogenase RA13_07070 ENOG4108VNY MOSC domain protein RA13_07075 ENOG4106DF1 RA13_07085 ENOG4105DZ6 Band 7 protein RA13_07100 ENOG4105N67 Proton-coupled thiamine transporter YuaJ RA13_07230 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) RA13_07240 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) RA13_07255 ENOG4108KS4 Spore coat protein RA13_07260 ENOG4107SBE Glycosyl transferase (Group 1 RA13_07275 ENOG4107SBE Glycosyl transferase (Group 1 RA13_07280 ENOG4108IAJ Nad-dependent epimerase dehydratase RA13_07295 ENOG4105E4F Isochorismate synthase RA13_07300 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) RA13_07305 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) RA13_07310 ENOG4108IPT Naphthoate synthase RA13_07315 ENOG4105CEY Amp-dependent synthetase and ligase RA13_07320 ENOG4105DTQ mandelate racemase muconate lactonizing RA13_07325 ENOG4105DSE periplasmic solute binding protein RA13_07330 ENOG4105DIK (ABC) transporter RA13_07335 ENOG4105CC5 ABC transporter RA13_07340 ENOG4105CC5 ABC transporter RA13_07345 ENOG4108YQE rare lipoprotein a RA13_07365 ENOG4105NRA 50s ribosomal protein l31 type b RA13_07370 ENOG4105CKI cobalamin synthesis protein RA13_07375 ENOG4108V2W Carbonate dehydratase RA13_07380 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) RA13_07385 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) RA13_07400 ENOG4108RMU ferritin dps family protein RA13_07420 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component RA13_07430 ENOG4105D2X ABC transporter substrate-binding protein RA13_07445 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase RA13_07450 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP RA13_07455 ENOG4105CAQ asparagine synthetase RA13_07460 ENOG4105C85 amino acid RA13_07465 ENOG4108Z0R Transferase RA13_07470 ENOG4105E8V Alpha Beta Hydrolase Fold protein RA13_07495 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family RA13_07500 ENOG4105DVE abc transporter atp-binding protein RA13_07510 ENOG4105C19 ABC transporter RA13_07515 ENOG4107R34 abc transporter permease protein RA13_07525 ENOG4105EWM Histidine kinase RA13_07530 ENOG4105C19 ABC transporter RA13_07540 ENOG4106UBQ RA13_07545 ENOG410605W Major Facilitator RA13_07550 ENOG4105BZU Histidine kinase RA13_07560 ENOG4105C8T Leucyl-tRNA synthetase RA13_07565 ENOG41085GJ domain protein RA13_07575 ENOG4105NTD Inherit from COG: Hydrolase RA13_07580 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) RA13_07585 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) RA13_07590 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) RA13_07600 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) RA13_07605 ENOG4106A3M Cytochrome p-450 RA13_07615 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component RA13_07625 ENOG41075H3 AraC family transcriptional regulator RA13_07635 ENOG4105F5H Glycosyl Hydrolase Family 88 RA13_07645 ENOG4105DDC Oxidoreductase domain protein RA13_07650 ENOG4105MU9 integral membrane protein RA13_07660 ENOG4105C94 Transporter RA13_07665 ENOG4105CBX hi0933 family RA13_07680 ENOG4105YW5 deoR family transcriptional regulator RA13_07685 ENOG4105C7N Xanthine uracil vitamin C permease RA13_07690 ENOG4107QSE Dipeptidase RA13_07695 ENOG4105C6T cysteine synthase RA13_07700 ENOG4107F58 2'-5' rna ligase RA13_07715 ENOG4108IUM Glycogen debranching enzyme RA13_07720 ENOG4108V15 phosphotransferase enzyme family RA13_07730 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) RA13_07735 ENOG4105C8F Beta-lactamase domain protein RA13_07740 ENOG4105C6K Malic enzyme RA13_07755 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ RA13_07770 ENOG4108VDD TRNA binding domain protein RA13_07780 ENOG4105DFU Cell wall formation (By similarity) RA13_07800 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase RA13_07805 ENOG4105ETE Transcriptional regulator (LacI family RA13_07810 ENOG4107R0U MotA TolQ exbB proton channel RA13_07815 ENOG4105ER2 Ompa motb domain protein RA13_07820 ENOG4105DGU Histone deacetylase RA13_07825 ENOG4105W87 Cbs domain RA13_07830 ENOG4105F1V Acetoin utilization protein RA13_07845 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) RA13_07850 ENOG4105EGI Transcriptional regulator RA13_07865 ENOG4105FBA Phospholipase Carboxylesterase RA13_07875 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase RA13_07880 ENOG4108VGI doxx family RA13_07900 ENOG4105CHJ isochorismatase hydrolase RA13_07920 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) RA13_07925 ENOG4105BZU Histidine kinase RA13_07935 ENOG4105U5Y Transcriptional regulator RA13_07970 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) RA13_07975 ENOG4105EFZ amidohydrolase RA13_07980 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) RA13_07985 ENOG4105D07 Signal peptide peptidase, SppA RA13_07990 ENOG4105VK3 rdd domain containing protein RA13_08000 ENOG4105KBJ sporulation protein ytfj RA13_08005 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) RA13_08015 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) RA13_08020 ENOG4105EPU Molybdenum cofactor synthesis domain protein RA13_08025 ENOG4105CDH Citrulline--aspartate ligase RA13_08030 ENOG4105CH7 arginosuccinase RA13_08045 ENOG4105E8R UPF0173 metal-dependent hydrolase RA13_08060 ENOG4105SFS phosphoesterase RecJ domain protein RA13_08065 ENOG4106EVM RA13_08075 ENOG4105VV2 RA13_08085 ENOG4105C6K Malic enzyme RA13_08090 ENOG4108IEY Carboxyl transferase domain RA13_08100 ENOG4105CTQ phosphohexokinase RA13_08105 ENOG4105CA9 Pyruvate kinase RA13_08110 ENOG4105FS0 cytoplasmic membrane protein RA13_08115 ENOG4108REF Sporulation integral membrane protein ytvi RA13_08125 ENOG4105BZN citrate synthase RA13_08130 ENOG4108HMX isocitrate dehydrogenase (NADP) RA13_08140 ENOG4105DPZ Two component transcriptional regulator (Winged helix family RA13_08145 ENOG4105BZU Histidine kinase RA13_08150 ENOG4105C2M dna polymerase I RA13_08155 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) RA13_08165 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) RA13_08170 ENOG4105CV8 reductase RA13_08175 ENOG4105F27 Major Facilitator RA13_08180 ENOG4105KVH Transcriptional regulator RA13_08185 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase RA13_08190 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) RA13_08195 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) RA13_08215 ENOG4108TDW sporulation protein YtxC RA13_08220 ENOG4105C22 threonyL-tRNA synthetase RA13_08225 ENOG4105U0R haloacid dehalogenase-like hydrolase RA13_08230 ENOG4108HRK Histidine kinase RA13_08235 ENOG4105DY9 regulatoR RA13_08245 ENOG41067MG lrgb family RA13_08265 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) RA13_08270 ENOG4105VJV 50s ribosomal protein L35 RA13_08275 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) RA13_08280 ENOG410696E Membrane RA13_08290 ENOG4105CN9 Peptidase m42 family protein RA13_08295 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase RA13_08305 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) RA13_08325 ENOG4105EF1 ribulokinase RA13_08330 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase RA13_08340 ENOG4108MDK Dehydrogenase RA13_08355 ENOG4105DRS transport system, permease RA13_08360 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) RA13_08375 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) RA13_08380 ENOG4105CQB FAD linked oxidase domain protein RA13_08390 ENOG41067MF small acid-soluble spore protein RA13_08395 ENOG4108RWN rrna methyltransferase RA13_08400 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) RA13_08405 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) RA13_08425 ENOG4105DCG PHP domain protein RA13_08430 ENOG4105C98 muts2 protein RA13_08445 ENOG4105CEY Amp-dependent synthetase and ligase RA13_08450 ENOG4107Z3H Transcriptional regulator, TetR family RA13_08455 ENOG41060WC Enoyl-CoA hydratase RA13_08460 ENOG4105BZJ Electron transfer flavoprotein RA13_08465 ENOG4105C10 Electron transfer flavoprotein RA13_08470 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) RA13_08475 ENOG4105K63 Thioredoxin RA13_08480 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) RA13_08485 ENOG4105CFH Aspartokinase RA13_08495 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit RA13_08515 ENOG4105PFC Transcriptional regulator RA13_08520 ENOG41067TZ transcriptional regulator, MarR family RA13_08525 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) RA13_08530 ENOG4108XJQ germination protein RA13_08535 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) RA13_08540 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) RA13_08545 ENOG4105M59 Phosphodiesterase, mj0936 family RA13_08555 ENOG4107KM7 Heat induced stress protein YflT RA13_08560 ENOG4105I4A GCN5-related N-acetyltransferase RA13_08575 ENOG4105C7K acetolactate synthase RA13_08580 ENOG4108ZP8 Acetolactate synthase small subunit RA13_08585 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase RA13_08590 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) RA13_08595 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) RA13_08600 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) RA13_08605 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) RA13_08615 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation RA13_08620 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) RA13_08630 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) RA13_08645 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) RA13_08655 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) RA13_08665 ENOG4105D52 delta-aminolevulinic acid dehydratase RA13_08670 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase RA13_08675 ENOG41068KH stage VI sporulation protein D RA13_08680 ENOG4106AR7 Spore coat protein RA13_08690 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) RA13_08695 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase RA13_08700 ENOG4106A3R peptidase RA13_08710 ENOG4108Z03 MAF-like protein RA13_08715 ENOG4105W5Q DNA repair protein (RadC RA13_08720 ENOG4105DFF Rod shape-determining protein mreb RA13_08725 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) RA13_08730 ENOG4105YHC Rod shape-determining protein MreD RA13_08735 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) RA13_08740 ENOG4107QMS site-determining protein RA13_08755 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) RA13_08760 ENOG4105X36 (ribosomal) protein RA13_08765 ENOG4105K46 50S ribosomal protein l27 RA13_08775 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control RA13_08785 ENOG4105CQC Prephenate dehydratase RA13_08800 ENOG4108IYU L-aspartate oxidase RA13_08805 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase RA13_08810 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) RA13_08815 ENOG4106678 morphogenetic protein associated with SpoVID RA13_08830 ENOG4105VZJ PTS System RA13_08835 ENOG4105VCP PTS System RA13_08840 ENOG4105CK1 PTS System RA13_08845 ENOG4105F8D glycoside hydrolase family 4 RA13_08850 ENOG4108X79 transcriptional regulator RA13_08855 ENOG410901P UPF0249 protein RA13_08875 ENOG4105CDY transcriptional regulatory protein RA13_08900 ENOG4105IE8 Alpha-ketoglutarate permease RA13_08910 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) RA13_08915 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) RA13_08920 ENOG41061AI Protein of unknown function (DUF2905) RA13_08925 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) RA13_08930 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) RA13_08935 ENOG4105VIE preprotein translocase, subunit YajC RA13_08940 ENOG4105NAP RA13_08945 ENOG4108QG2 Membrane RA13_08950 ENOG4105CKP Polysaccharide Biosynthesis Protein RA13_08960 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) RA13_08965 ENOG4105NCW Trka-c domain protein RA13_08970 ENOG41067VP Protein of unknown function (DUF1049) RA13_08975 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) RA13_08990 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) RA13_08995 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase RA13_09005 ENOG4105CUT histidyl-tRNA synthetase RA13_09010 ENOG4105C9M aspartyl-trna synthetase RA13_09020 ENOG4105CUZ uba thif-type nad fad binding protein RA13_09025 ENOG4105D1H recombination factor protein RarA RA13_09035 ENOG4105C3J Cysteine desulfurase RA13_09040 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) RA13_09050 ENOG4105C7H Helicase, RecD TraA family RA13_09060 ENOG41060CR RA13_09070 ENOG4105DRP amino acid AbC transporter RA13_09075 ENOG4105EAD ABC transporter RA13_09080 ENOG4105CT1 (ABC) transporter RA13_09085 ENOG4105CDA abc transporter atp-binding protein RA13_09090 ENOG4105C02 permease RA13_09095 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) RA13_09100 ENOG4105VBH UPF0297 protein RA13_09105 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) RA13_09110 ENOG4105VPH UPF0473 protein RA13_09115 ENOG4105HHA aminodeoxychorismate lyase RA13_09120 ENOG4108VQJ O-methyltransferase RA13_09125 ENOG4105XYU peptidase (U32 family) RA13_09130 ENOG4105CFP Peptidase U32 RA13_09135 ENOG4105DBI uridine monophosphokinase RA13_09140 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) RA13_09160 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) RA13_09175 ENOG4105C28 cystathionine RA13_09190 ENOG4108JB9 formate dehydrogenase RA13_09195 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) RA13_09205 ENOG4105TMB Formate nitrite transporter RA13_09220 ENOG41082JN Transcriptional regulator RA13_09225 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) RA13_09230 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) RA13_09235 ENOG4105D94 Major Facilitator Superfamily RA13_09240 ENOG4107RSM transcriptional regulator RA13_09245 ENOG4105WDR RA13_09255 ENOG4108MEK Metal-binding protein YodA RA13_09260 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) RA13_09270 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) RA13_09295 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family RA13_09325 ENOG41067XF inhibitor RA13_09330 ENOG4105ST3 Transcriptional regulator RA13_09360 ENOG4108DBC nitroreductase RA13_09365 ENOG4105KVH Transcriptional regulator RA13_09390 ENOG4107Y5K Resolvase RA13_09430 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) RA13_09435 ENOG41080BT SNARE associated Golgi RA13_09460 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase RA13_09465 ENOG4105CQW ribosome biogenesis GTPase YqeH RA13_09470 ENOG4105E2X shikimate dehydrogenase RA13_09475 ENOG410812S Rna-binding protein RA13_09480 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) RA13_09485 ENOG4108WF2 Metal Dependent Phosphohydrolase RA13_09495 ENOG4108D32 Methyltransferase RA13_09505 ENOG4105KQC Competence protein RA13_09510 ENOG4108UK2 deaminase RA13_09515 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 RA13_09525 ENOG4105TQK DNA polymerase iii, delta' subunit RA13_09530 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) RA13_09535 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) RA13_09540 ENOG4108ZRV stage ii sporulation protein p RA13_09550 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) RA13_09555 ENOG4105CSA Coproporphyrinogen iii oxidase RA13_09560 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) RA13_09565 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ RA13_09570 ENOG4105CFG Acts as a chaperone (By similarity) RA13_09575 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) RA13_09580 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) RA13_09585 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) RA13_09590 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) RA13_09605 ENOG4105KTH gatB Yqey RA13_09615 ENOG4105DI5 UPF0365 protein RA13_09645 ENOG41068P3 sporulation protein YqfC RA13_09650 ENOG4105EI1 sporulation protein yqfd RA13_09655 ENOG4105C9A Phoh family RA13_09660 ENOG4105CTJ Metal Dependent Phosphohydrolase RA13_09665 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) RA13_09670 ENOG4107YR5 Diacylglycerol kinase RA13_09675 ENOG4105KG3 cytidine deaminase RA13_09680 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) RA13_09690 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) RA13_09695 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit RA13_09700 ENOG4105C38 Glycyl-tRNA synthetase beta subunit RA13_09710 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) RA13_09715 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 RA13_09720 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) RA13_09725 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) RA13_09740 ENOG4105EGD dinuclear metal center protein, YbgI family RA13_09745 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) RA13_09760 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) RA13_09765 ENOG41069ZM Protein of unknown function (DUF2624) RA13_09770 ENOG4108JYZ YitT family RA13_09775 ENOG4105N80 Ferric uptake regulator, Fur family RA13_09780 ENOG4108U5J '-nucleotidase RA13_09785 ENOG41063Y9 RA13_09790 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) RA13_09805 ENOG4105SXS Protein of unknown function (DUF456) RA13_09810 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) RA13_09820 ENOG4107RF6 penicillin-binding protein RA13_09825 ENOG4105CVA phosphate RA13_09830 ENOG4105C8U phosphate abc transporter RA13_09835 ENOG4105E2Z phosphate ABC transporter (Permease RA13_09840 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) RA13_09845 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) RA13_09850 ENOG41068DG YceG-like family RA13_09870 ENOG4105WDJ 50S ribosomal protein L33 RA13_09875 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase RA13_09885 ENOG4107ZXI Rhomboid family RA13_09900 ENOG4105E0M Sulfatase RA13_09925 ENOG4105C5X domain protein RA13_09950 ENOG4105C37 (CBS) domain RA13_10015 ENOG4105VFR signal peptidase RA13_10025 ENOG4108IMY Transcriptional regulator RA13_10040 ENOG4105C0D helicase RA13_10045 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) RA13_10050 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor RA13_10055 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor RA13_10060 ENOG4105WZW rhodanese family RA13_10065 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) RA13_10070 ENOG4105KST dependent repressor RA13_10085 ENOG4105CBJ Metal-dependent enzyme RA13_10095 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) RA13_10100 ENOG4105DC7 peptidase M24 RA13_10105 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) RA13_10115 ENOG4105CD2 stage iii sporulation protein aa RA13_10120 ENOG4105KR5 Stage iii sporulation protein RA13_10125 ENOG4108CQH stage III sporulation protein AC RA13_10130 ENOG4105KQ4 Stage iii sporulation protein ad RA13_10140 ENOG410644B Stage III sporulation protein af RA13_10160 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase RA13_10165 ENOG4108ZSR alkaline shock protein RA13_10170 ENOG4105M7K Involved in the transcription termination process (By similarity) RA13_10175 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) RA13_10180 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) RA13_10185 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) RA13_10190 ENOG4105CTB Polyprenyl synthetase RA13_10200 ENOG4105DX0 Hemolysin A RA13_10205 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) RA13_10210 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) RA13_10215 ENOG4105S1Z Stage IV sporulation protein B RA13_10220 ENOG4107QQR Sporulation RA13_10230 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase RA13_10240 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase RA13_10245 ENOG4108QXE glycerophosphoryl diester phosphodiesterase RA13_10255 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase RA13_10260 ENOG4105C1G acyl-Coa dehydrogenase RA13_10270 ENOG4105DXD 2-methylcitrate dehydratase RA13_10275 ENOG4105CR4 methylisocitrate lyase RA13_10300 ENOG4105CKM Branched-chain carboxylic acid kinase RA13_10315 ENOG4105CPP Dehydrogenase, E1 component RA13_10320 ENOG4105C7S Dehydrogenase RA13_10330 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) RA13_10335 ENOG4108Y6J UPF0403 protein RA13_10340 ENOG4108HW3 (ABC) transporter RA13_10345 ENOG4105E5Q amino acid AbC transporter RA13_10350 ENOG4105CDA abc transporter atp-binding protein RA13_10355 ENOG4108QEG Membrane RA13_10360 ENOG4108VZI ErfK ybiS ycfS ynhG family protein RA13_10365 ENOG4108ZVT methylmalonyl-coA epimerase RA13_10370 ENOG4108HNZ carboxyl transferase RA13_10375 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) RA13_10380 ENOG4108NA0 Uncharacterized conserved protein (COG2071) RA13_10385 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) RA13_10395 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) RA13_10400 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) RA13_10405 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase RA13_10410 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) RA13_10415 ENOG410861F 50S ribosomal protein L33 RA13_10425 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase RA13_10435 ENOG4105II7 pyrroline-5-carboxylate reductase RA13_10440 ENOG41069FQ Metallo-beta-lactamase superfamily RA13_10445 ENOG4108IXY short-chain dehydrogenase reductase RA13_10480 ENOG4105C02 permease RA13_10490 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) RA13_10500 ENOG4108XET gCN5-related N-acetyltransferase RA13_10505 ENOG4105KAC Antibiotic biosynthesis monooxygenase RA13_10510 ENOG4105RHY Pfam:UPF0157 RA13_10515 ENOG4106HZJ RA13_10535 ENOG4105CPC Aldo Keto reductase RA13_10545 ENOG4108YZ4 nudix hydrolase RA13_10555 ENOG4108IMY Transcriptional regulator RA13_10560 ENOG4105HDK L-asparaginase RA13_10565 ENOG4108IJ0 Aspartate ammonia-lyase RA13_10570 ENOG4105DFD Na H antiporter RA13_10585 ENOG4105MZ9 stage II sporulation protein m RA13_10590 ENOG4105I3K Ferric uptake regulator, Fur family RA13_10600 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) RA13_10605 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) RA13_10610 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) RA13_10615 ENOG4105DZ1 carboxypeptidase RA13_10620 ENOG41082AN stage II sporulation protein RA13_10625 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) RA13_10630 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) RA13_10645 ENOG41090VF Stage v sporulation protein ac RA13_10650 ENOG4105CZ3 stage V sporulation protein ad RA13_10660 ENOG4105G6R Stage v sporulation protein ae RA13_10670 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) RA13_10675 ENOG4105PTM secreted protein RA13_10680 ENOG4107ZE5 PPIases accelerate the folding of proteins RA13_10690 ENOG4108M26 parallel beta-helix repeat protein RA13_10710 ENOG4105EG2 ABC transporter, permease RA13_10720 ENOG4107FKK extracellular solute-binding protein family 1 RA13_10745 ENOG4105CK5 oxidoreductase RA13_10760 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) RA13_10765 ENOG4105C3F Signal peptidase i RA13_10775 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) RA13_10780 ENOG4108R6K riboflavin synthase, subunit alpha RA13_10785 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) RA13_10790 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) RA13_10810 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) RA13_10815 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) RA13_10825 ENOG4105DZ1 carboxypeptidase RA13_10830 ENOG4108JIC nucleoside recognition domain protein RA13_10840 ENOG4105FE9 pseudouridine synthase RA13_10850 ENOG4107TWT Cytochrome c biogenesis protein RA13_10855 ENOG4105CRE cytochrome C RA13_10860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family RA13_10865 ENOG4105BZU Histidine kinase RA13_10880 ENOG4105FF2 Type I DHQase RA13_10885 ENOG4108JQ1 Dehydrogenase RA13_10890 ENOG4108SAX Membrane RA13_10900 ENOG4105T7X RA13_10905 ENOG4105C9U ATP-dependent DNA helicase RecQ RA13_10910 ENOG4105I7S Abortive infection protein RA13_10925 ENOG4107RGJ metallophosphoesterase RA13_10945 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) RA13_10955 ENOG4105MSI germination protein ypeb RA13_10970 ENOG4105CAT Cytidine monophosphate kinase RA13_10975 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) RA13_10980 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) RA13_10995 ENOG4105S2F RA13_11000 ENOG41065D1 RA13_11005 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) RA13_11010 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase RA13_11025 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) RA13_11030 ENOG4105K70 DNA-binding protein RA13_11035 ENOG4105EUJ GTP cyclohydrolase i RA13_11045 ENOG4105XXQ heptaprenyl diphosphate synthase component I RA13_11050 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) RA13_11055 ENOG4105EAH synthase RA13_11060 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) RA13_11065 ENOG4105BZU Histidine kinase RA13_11070 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase RA13_11080 ENOG4105KHN chorismate mutase RA13_11085 ENOG4105CRQ synthase (Component I) RA13_11100 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase RA13_11105 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) RA13_11115 ENOG4105CIH Imidazole acetol-phosphate transaminase RA13_11125 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase RA13_11130 ENOG41068YB TPR repeat-containing protein RA13_11150 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) RA13_11170 ENOG4105F0F Oxalate decarboxylase RA13_11175 ENOG4108JYZ YitT family RA13_11180 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase RA13_11185 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) RA13_11190 ENOG4108Z5K methylglyoxal synthase RA13_11195 ENOG4105FJR Lmbe family RA13_11200 ENOG4105CPK Glycosyl transferase (Group 1 RA13_11205 ENOG4105DJ0 Poly(A) Polymerase RA13_11210 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase RA13_11220 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) RA13_11225 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) RA13_11230 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) RA13_11235 ENOG4105DVT helicase RA13_11240 ENOG4105YAC RA13_11250 ENOG4105CHM Aminotransferase RA13_11255 ENOG4105C5S asparaginyl-tRNA synthetase RA13_11265 ENOG4105CSM endonuclease III RA13_11275 ENOG4105BZ4 penicillin-binding protein RA13_11330 ENOG4107X2U Inherit from COG: Exonuclease-like protein RA13_11340 ENOG4108UKS UPF0398 protein RA13_11355 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) RA13_11370 ENOG4105DVT helicase RA13_11375 ENOG4105CHR reductase RA13_11385 ENOG4108M60 Transcriptional regulator RA13_11390 ENOG4105D7K pfkb domain protein RA13_11395 ENOG4108UHU Aldolase RA13_11400 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) RA13_11405 ENOG4105CTD carboxy-peptidase RA13_11410 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) RA13_11415 ENOG4105C2W permease RA13_11420 ENOG41065KQ synthase RA13_11435 ENOG410890F Dynamin family RA13_11460 ENOG41081VK Ribonuclease RA13_11500 ENOG4105CVG Homoserine O-transsuccinylase RA13_11525 ENOG4108Y6J UPF0403 protein RA13_11530 ENOG4107YX5 Pfam:DUF548 RA13_11550 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) RA13_11560 ENOG4108UT2 hemolysin iii RA13_11570 ENOG4105C7B Threonine dehydratase RA13_11580 ENOG4108KF3 Electron transport protein SCO1 SenC RA13_11585 ENOG41090WU lipolytic protein G-D-S-L family RA13_11590 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) RA13_11610 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) RA13_11615 ENOG4105E0X reductase RA13_11630 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) RA13_11635 ENOG41086D8 Transcriptional regulator RA13_11640 ENOG4106BHF RA13_11650 ENOG4105VMP Transcriptional regulator RA13_11660 ENOG4108M1A Chitin-binding protein RA13_11680 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) RA13_11690 ENOG4107T32 3-phytase (EC 3.1.3.8) RA13_11725 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) RA13_11740 ENOG4107S4Y M20 DapE family protein YgeY RA13_11745 ENOG4108TSC N-acetyltransferase RA13_11750 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein RA13_11780 ENOG410841Q phosphoesterase PA-phosphatase related protein RA13_11785 ENOG4106Z5R RA13_11795 ENOG4105D3A purine nucleoside phosphorylase DeoD-type RA13_11800 ENOG4108VXD carboxy-peptidase RA13_11820 ENOG4105E1V na solute symporter RA13_11835 ENOG4105FBA Phospholipase Carboxylesterase RA13_11850 ENOG41090U3 tautomerase RA13_11870 ENOG4105FR1 rard protein RA13_11890 ENOG4106SCS STAS domain RA13_11895 ENOG4105VTR Integrase RA13_11950 ENOG4105CDU Replicative dna helicase RA13_12020 ENOG4105CAR Terminase, large subunit RA13_12100 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj RA13_12110 ENOG41068G1 RA13_12130 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase RA13_12155 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase RA13_12175 ENOG4107QMU Mate efflux family protein RA13_12190 ENOG4105K4H Nlp p60 protein RA13_12200 ENOG4105GMT ATPase associated with various cellular activities aaa_5 RA13_12205 ENOG4107T89 von Willebrand factor, type A RA13_12215 ENOG4105C7S Dehydrogenase RA13_12220 ENOG4105C09 Bile acid RA13_12225 ENOG4105C8J )-transporter RA13_12230 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) RA13_12235 ENOG4105EWU Squalene--hopene cyclase RA13_12240 ENOG4105C26 Dehydrogenase RA13_12260 ENOG4105SCY DNAK suppressor RA13_12265 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) RA13_12275 ENOG4105C9U ATP-dependent DNA helicase RecQ RA13_12280 ENOG41069ER domain protein RA13_12285 ENOG4107RUZ Sss sodium solute transporter superfamily RA13_12295 ENOG4108S01 response regulator RA13_12300 ENOG4108ZGX Histidine kinase RA13_12305 ENOG4105ECK Fatty Acid Desaturase RA13_12320 ENOG4108SJC Membrane RA13_12330 ENOG4105KTU Transcriptional regulator, arsr family RA13_12350 ENOG4108W8B Beta-lactamase domain protein RA13_12360 ENOG4105FTV AraC Family Transcriptional Regulator RA13_12365 ENOG4108Z7R Chaperone CsaA RA13_12370 ENOG4108IG5 Transcriptional regulator RA13_12385 ENOG4108J2R molybdopterin oxidoreductase RA13_12390 ENOG4108M3J Dehydrogenase RA13_12395 ENOG4107U6E carbohydrate kinase FGGY RA13_12400 ENOG4105IE8 Alpha-ketoglutarate permease RA13_12425 ENOG4108V4B ThiJ pfpI RA13_12460 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) RA13_12465 ENOG4105C5Q Transcriptional regulator RA13_12470 ENOG4105CBC glutamate synthase RA13_12480 ENOG4105CB2 alcohol dehydrogenase RA13_12485 ENOG4108KSA LysR family transcriptional regulator RA13_12490 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) RA13_12550 ENOG4108N2V aldose 1-epimerase RA13_12555 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family RA13_12560 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) RA13_12565 ENOG4105C0W non-ribosomal peptide synthetase RA13_12575 ENOG4105C0W non-ribosomal peptide synthetase RA13_12590 ENOG4106U2H Protein of unknown function (DUF1360) RA13_12595 ENOG4105F32 YngK protein RA13_12600 ENOG4105C1G acyl-Coa dehydrogenase RA13_12605 ENOG4105CEY Amp-dependent synthetase and ligase RA13_12610 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase RA13_12615 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit RA13_12625 ENOG4107QX3 carboxylase RA13_12635 ENOG4107T5V SNARE associated Golgi RA13_12640 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase RA13_12680 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) RA13_12685 ENOG4105K4P CoA-binding domain protein RA13_12690 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) RA13_12695 ENOG4105W8X HesB YadR YfhF-family protein RA13_12710 ENOG41067CD Small, acid-soluble spore protein Tlp RA13_12725 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen RA13_12730 ENOG4108I0Z Aconitate hydratase RA13_12740 ENOG4107DZX Small, acid-soluble spore protein P RA13_12765 ENOG4107QIV Cytochrome c biogenesis protein RA13_12775 ENOG4105VXM UPF0154 protein RA13_12785 ENOG4105CV1 Transketolase (EC 2.2.1.1) RA13_12790 ENOG4105VPS UPF0291 protein RA13_12795 ENOG4108SVB resolvase RA13_12805 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) RA13_12815 ENOG4105PGS Spore coat protein RA13_12840 ENOG4105K7W phage-related replication protein RA13_12845 ENOG4105FVX RA13_12860 ENOG4105XPP Protein of unknown function (DUF1275) RA13_12900 ENOG41075D4 Aminoglycoside 6-adenylyltransferase RA13_12915 ENOG4105CJ1 ABC, transporter RA13_12930 ENOG410780I phosphoprotein phosphatase activity RA13_12945 ENOG4108RAV Conserved protein RA13_12960 ENOG4108ZMQ domain protein RA13_12965 ENOG41090E6 transcriptional regulator MERR family RA13_12995 ENOG41083Q9 chitosanase RA13_13020 ENOG410907G RA13_13060 ENOG4108J4B Beta-lactamase RA13_13125 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) RA13_13155 ENOG4105K63 Thioredoxin RA13_13165 ENOG4105XXY Thioredoxin RA13_13175 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) RA13_13185 ENOG4108WUH Transcriptional regulator, TetR family RA13_13190 ENOG4105ETE Transcriptional regulator (LacI family RA13_13200 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component RA13_13215 ENOG4108HKT sucrose-6-phosphate hydrolase RA13_13275 ENOG41090AA RA13_13305 ENOG4108RZ2 Glycoside hydrolase family 16 RA13_13345 ENOG4106ANW SMI1_KNR4 RA13_13350 ENOG4106BHF RA13_13355 ENOG4105C19 ABC transporter RA13_13405 ENOG4108U7W acetyltransferase RA13_13425 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase RA13_13485 ENOG4105C5F glutamine synthetase RA13_13490 ENOG4105KV4 Transcriptional regulator RA13_13495 ENOG4105CXI aluminum resistance protein RA13_13500 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) RA13_13515 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) RA13_13595 ENOG4105U6W MutT NUDIX family protein RA13_13610 ENOG4106ITI Glutaredoxin RA13_13615 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) RA13_13635 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) RA13_13640 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) RA13_13770 ENOG4106J9J DNA polymerase RA13_13780 ENOG4106IVX RA13_13785 ENOG4106PTB DnaB-like helicase C terminal domain RA13_13795 ENOG41088HM RA13_13800 ENOG4106YR8 RA13_13830 ENOG4105K7W phage-related replication protein RA13_13865 ENOG4108J9Q DNA ligase RA13_14020 ENOG4107D0N RA13_14075 ENOG4107NTZ RA13_14120 ENOG4108NE4 RA13_14150 ENOG4105ZUG RA13_14160 ENOG4105ZUG RA13_14165 ENOG4105K70 DNA-binding protein RA13_14175 ENOG4106QVS RA13_14255 ENOG41068G1 RA13_14315 ENOG4105E4C Lytic transglycosylase catalytic RA13_14375 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) RA13_14425 ENOG4106ANW SMI1_KNR4 RA13_14430 ENOG4106BHF RA13_14440 ENOG4107Y9E nuclease RA13_14460 ENOG4106F1P AAA ATPase, central domain protein RA13_14465 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase RA13_14470 ENOG4105U6W MutT NUDIX family protein RA13_14475 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) RA13_14480 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) RA13_14485 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) RA13_14505 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) RA13_14535 ENOG4108X3M OsmC Ohr family protein RA13_14540 ENOG4105K7W phage-related replication protein RA13_14550 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin RA13_14560 ENOG4106A3M Cytochrome p-450 RA13_14570 ENOG4105C0W non-ribosomal peptide synthetase RA13_14590 ENOG4108KQ6 Enoyl-CoA hydratase RA13_14595 ENOG4108MGH Enoyl-CoA hydratase RA13_14600 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase RA13_14610 ENOG41062T2 Acyl carrier protein RA13_14620 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase RA13_14625 ENOG4108151 Beta-lactamase domain protein RA13_14630 ENOG4105W1N transcriptional regulator RA13_14635 ENOG4105IIP Membrane RA13_14645 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) RA13_14650 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) RA13_14665 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) RA13_14675 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) RA13_14685 ENOG4105MCT stage V sporulation protein S RA13_14690 ENOG4105D48 metallophosphoesterase RA13_14700 ENOG4108A04 Beta-lactamase RA13_14715 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase RA13_14730 ENOG4105XZV Protein of unknown function (DUF3243) RA13_14760 ENOG4105FDP GntR family transcriptional regulator RA13_14765 ENOG4105CNU cell division protein FtsK RA13_14775 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit RA13_14785 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) RA13_14795 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) RA13_14800 ENOG4108S0H Dipicolinic acid synthetase, b subunit RA13_14805 ENOG4105E35 Dipicolinate synthase subunit A RA13_14815 ENOG4105C1V Peptidase, M16 RA13_14825 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) RA13_14830 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) RA13_14835 ENOG4105DTN riboflavin biosynthesis protein ribF RA13_14840 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) RA13_14845 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) RA13_14850 ENOG4105W7A Protein of unknown function (DUF503) RA13_14855 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) RA13_14860 ENOG4105VHM ribosomal protein RA13_14865 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination RA13_14870 ENOG4105CHV Transcription elongation factor NusA RA13_14875 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) RA13_14910 ENOG4105KNE Phosphatidate cytidylyltransferase RA13_14920 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) RA13_14930 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) RA13_14935 ENOG4105CE9 30S ribosomal protein S2 RA13_14945 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) RA13_14960 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis RA13_14965 ENOG4105CBS Chea signal transduction histidine kinase RA13_14970 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) RA13_14980 ENOG4105FZW flagellar biosynthesis regulator FlhF RA13_14985 ENOG4105D7B Flagellar biosynthesis protein flha RA13_14990 ENOG4105D00 flagellar biosynthetic protein flhB RA13_14995 ENOG4105D19 Role in flagellar biosynthesis (By similarity) RA13_15000 ENOG4105VS8 Flagellar biosynthetic protein fliq RA13_15005 ENOG4105CN7 Flagellar biosynthetic protein FliP RA13_15015 ENOG4107YTP response regulator receiver protein RA13_15020 ENOG4105DD5 Flagellar motor switch protein RA13_15025 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) RA13_15035 ENOG41068WV flagellar FlbD family protein RA13_15040 ENOG4108JQA flagellar RA13_15045 ENOG410822I Flagellar hook capping protein RA13_15050 ENOG410696Y Flagellar hook-length control protein RA13_15060 ENOG4106YF4 Flagellar biosynthesis chaperone RA13_15075 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) RA13_15080 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) RA13_15085 ENOG4105VQ0 flagellar hook-basal body complex protein fliE RA13_15090 ENOG4108ZC9 flagellar basal-body rod protein flgc RA13_15095 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) RA13_15105 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) RA13_15110 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) RA13_15115 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) RA13_15120 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) RA13_15125 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) RA13_15130 ENOG4105C79 DNA protecting protein DprA RA13_15135 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha RA13_15140 ENOG4105CMV Succinyl-CoA synthetase subunit beta RA13_15145 ENOG4105VM1 flagellar RA13_15155 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) RA13_15160 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) RA13_15165 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) RA13_15170 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) RA13_15175 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) RA13_15185 ENOG4108BW8 UPF0109 protein RA13_15190 ENOG4105K5M 30s ribosomal protein S16 RA13_15200 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) RA13_15205 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) RA13_15210 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) RA13_15215 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) RA13_15220 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) RA13_15225 ENOG4105CHR reductase RA13_15230 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase RA13_15235 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) RA13_15240 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) RA13_15245 ENOG4105CB5 ATP-dependent DNA helicase recG RA13_15250 ENOG4105EJQ L-serine dehydratase RA13_15260 ENOG4105DP4 dak2 domain fusion protein ylov RA13_15265 ENOG4108ZAA Alkaline-shock protein RA13_15270 ENOG4105VB9 50S ribosomal protein l28 RA13_15280 ENOG4105FJ0 thiamine RA13_15285 ENOG4105DJV ribulose-phosphate 3-epimerase RA13_15290 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) RA13_15295 ENOG4105D9P serine threonine protein kinase RA13_15300 ENOG4108ZF3 Phosphatase RA13_15305 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs RA13_15310 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B RA13_15315 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) RA13_15320 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) RA13_15325 ENOG4105C25 Primosomal protein n' RA13_15330 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase RA13_15340 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) RA13_15345 ENOG4105KC4 UPF0296 protein RA13_15350 ENOG4105DSJ YicC domain protein RA13_15360 ENOG4105F23 Fibronectin-binding protein RA13_15375 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) RA13_15380 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) RA13_15385 ENOG4107S4M Sulfate adenylate transferase RA13_15395 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) RA13_15400 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) RA13_15405 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) RA13_15410 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) RA13_15415 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) RA13_15420 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain RA13_15425 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain RA13_15435 ENOG4105CXT aspartate transcarbamylase RA13_15445 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) RA13_15450 ENOG4105C34 Pseudouridine synthase RA13_15465 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) RA13_15480 ENOG4105DBK s4 domain protein RA13_15485 ENOG41067XK integral membrane protein RA13_15490 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) RA13_15495 ENOG4105DFA alanine racemase domain protein RA13_15500 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase RA13_15505 ENOG4105WR5 sporulation protein, YlmC YmxH family RA13_15515 ENOG4105DKW ABC transporter RA13_15525 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) RA13_15530 ENOG4105FFI sigma-e processing peptidase spoiiga RA13_15540 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) RA13_15550 ENOG4105K67 small basic protein RA13_15560 ENOG4108R2U division initiation protein RA13_15565 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) RA13_15570 ENOG4105D4A Cell wall formation (By similarity) RA13_15575 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) RA13_15580 ENOG4105CNI cell division protein FtsW RA13_15585 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) RA13_15590 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) RA13_15595 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) RA13_15600 ENOG4105CJN penicillin-binding protein RA13_15605 ENOG4105CJN penicillin-binding protein RA13_15615 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) RA13_15620 ENOG4108V6E Cell division protein mraZ RA13_15645 ENOG41067VY 50S ribosomal protein L32 RA13_15650 ENOG4105KNH Nucleic acid-binding protein RA13_15660 ENOG4105CDE UPF0348 protein RA13_15665 ENOG41063PX domain protein RA13_15670 ENOG4105D78 K07001 NTE family protein RA13_15675 ENOG4105H20 Sporulation integral membrane protein YlbJ RA13_15680 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) RA13_15685 ENOG4106H78 methyltransferase RA13_15690 ENOG4105WUC UPF0298 protein RA13_15715 ENOG4106UY4 Inherit from COG: Scp-like extracellular RA13_15720 ENOG41080XQ Signal transduction protein with cbs domains RA13_15735 ENOG41064X9 cytochrome C oxidase subunit IV RA13_15740 ENOG4105CCU oxidase (Subunit III) RA13_15745 ENOG4105BZ9 Cytochrome C oxidase, subunit I RA13_15755 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) RA13_15765 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) RA13_15770 ENOG4105CNI cell division protein FtsW RA13_15775 ENOG4105ZPI UPF0358 protein RA13_15790 ENOG4108IAB Phoh family RA13_15805 ENOG4105QA2 RA13_15810 ENOG4105CI3 gtp-binding protein typa RA13_15835 ENOG4105JQZ Methyltransferase RA13_15845 ENOG4105ECY inositol monophosphatase RA13_15860 ENOG4105WBI UPF0223 protein RA13_15865 ENOG4105CXN decarboxylase RA13_15885 ENOG4107QN2 dihydrolipoyl dehydrogenase RA13_15890 ENOG4105C7S Dehydrogenase RA13_15895 ENOG4105CPP Dehydrogenase, E1 component RA13_15915 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) RA13_15920 ENOG4108X4Q Hydrolase RA13_15925 ENOG4106148 UPF0356 protein RA13_15930 ENOG4105CN5 Metallo-Beta-Lactamase RA13_15940 ENOG4107ZYR domain protein RA13_15950 ENOG4105BZU Histidine kinase RA13_15975 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) RA13_15980 ENOG4105C5H ABC transporter RA13_15990 ENOG4105C3F Signal peptidase i RA13_15995 ENOG4105DM4 PTS System RA13_16000 ENOG4105DE4 1-phosphofructokinase RA13_16005 ENOG4105E98 transcriptional regulator DeoR family RA13_16010 ENOG4107RBB ABC transporter, permease RA13_16020 ENOG4107X8C Efflux transporter RND family MFP subunit RA13_16030 ENOG4105BZ1 (ABC) transporter RA13_16035 ENOG4105BZ1 (ABC) transporter RA13_16040 ENOG41067WU Molybdopterin converting factor (Subunit 1) RA13_16045 ENOG4108ZAF Molybdopterin RA13_16050 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein RA13_16055 ENOG4105CVM Molybdenum cofactor synthesis domain protein RA13_16060 ENOG4105D06 uba thif-type nad fad binding protein RA13_16065 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) RA13_16080 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen RA13_16085 ENOG4105D3R alkyl hydroperoxide reductase RA13_16090 ENOG4105D8X mechanosensitive ion channel RA13_16100 ENOG4105CH2 amidohydrolase RA13_16110 ENOG4105NQC Flavodoxin RA13_16140 ENOG4108XRC Protein of unknown function (DUF458) RA13_16145 ENOG4107IN1 Protein of unknown function (DUF1797) RA13_16150 ENOG4105WEF catalase RA13_16155 ENOG4105EPM Diguanylate phosphodiesterase RA13_16160 ENOG4105K6S Short-chain dehydrogenase reductase Sdr RA13_16170 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein RA13_16180 ENOG4105UIN RA13_16185 ENOG4107R88 Chemotaxis protein (CheV) RA13_16195 ENOG4105CHM Aminotransferase RA13_16200 ENOG4105BZU Histidine kinase RA13_16210 ENOG4105K4I Scp-like extracellular RA13_16215 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase RA13_16220 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer RA13_16230 ENOG4105F6S Spore photoproduct lyase RA13_16240 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) RA13_16245 ENOG4105KRI phosphocarrier protein (HPr RA13_16255 ENOG4105CID antiterminator RA13_16265 ENOG4105DC7 peptidase M24 RA13_16275 ENOG4105C59 p-type ATPase RA13_16290 ENOG4105F0V Cell wall hydrolase RA13_16320 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) RA13_16325 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) RA13_16330 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase RA13_16335 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) RA13_16345 ENOG4108K88 Membrane RA13_16355 ENOG4105E14 MotA TolQ exbB proton channel RA13_16360 ENOG4105ER2 Ompa motb domain protein RA13_16365 ENOG41090MY MarR family Transcriptional regulator RA13_16370 ENOG4105BZU Histidine kinase RA13_16390 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) RA13_16395 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) RA13_16405 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit RA13_16415 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase RA13_16420 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) RA13_16425 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) RA13_16430 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) RA13_16435 ENOG4105BZU Histidine kinase RA13_16440 ENOG4108TGC Acyltransferase RA13_16455 ENOG410900G Protein of unknown function (DUF421) RA13_16465 ENOG4105D0M Protease HtpX homolog RA13_16475 ENOG410681C small acid-soluble spore protein RA13_16485 ENOG4108WZW RNA polymerase sigma RA13_16490 ENOG4107TS3 membrane protein, TerC RA13_16500 ENOG4107T5V SNARE associated Golgi RA13_16520 ENOG4105FDF Could be involved in DNA repair (By similarity) RA13_16525 ENOG4105DQE DNA ligase RA13_16575 ENOG4105V75 Transcriptional regulator RA13_16580 ENOG4105CJW magnesium transporter RA13_16585 ENOG4106849 propeptide, pepSY amd peptidase M4 RA13_16625 ENOG4108W7F transporter, permease RA13_16640 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) RA13_16645 ENOG4105CVJ phosphoglycerate mutase RA13_16650 ENOG4107Y2X deaminase RA13_16660 ENOG4107TVC Glycosyl transferase, family 2 RA13_16680 ENOG4108ZHJ Organic hydroperoxide resistance protein RA13_16685 ENOG4105K56 Transcriptional regulator RA13_16700 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) RA13_16705 ENOG4105CIY formyltetrahydrofolate deformylase RA13_16710 ENOG41080TC multidrug resistance protein RA13_16720 ENOG4108428 Inherit from COG: -acetyltransferase RA13_16740 ENOG4105K7K Transcriptional regulator RA13_16750 ENOG4108S4H thioesterase Superfamily protein RA13_16755 ENOG4107TUM Amidinotransferase RA13_16760 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) RA13_16765 ENOG4108JQ7 (ABC) transporter RA13_16770 ENOG4107SN7 NLP P60 protein RA13_16775 ENOG4105DTQ mandelate racemase muconate lactonizing RA13_16780 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A RA13_16800 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component RA13_16805 ENOG4108ME1 Peptidase M55 D-aminopeptidase RA13_16815 ENOG4105C0H protease RA13_16825 ENOG4105CKK Glycosyl transferase, family 2 RA13_16830 ENOG4105EDW glycosyl transferase, family 39 RA13_16840 ENOG4107R7I amino acid RA13_16845 ENOG4107GRR phosphate transport regulator RA13_16850 ENOG4105CJ3 phosphate transporter RA13_16865 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase RA13_16895 ENOG41068G1 RA13_16905 ENOG410906S phage-like element pbsx protein xkdt RA13_16910 ENOG41066EA baseplate J family protein RA13_16915 ENOG4105MFU Protein of unknown function (DUF2634) RA13_16920 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase RA13_16930 ENOG4105X7F RA13_16935 ENOG4108WZM domain protein RA13_16940 ENOG4108FKH Transglycosylase SLT domain RA13_16950 ENOG4105MTC XkdN-like protein RA13_16955 ENOG4105FR7 XkdM protein, phage-like element PBSX RA13_16960 ENOG4105PQS phage protein RA13_16975 ENOG41060SN RA13_17000 ENOG4108MDF Phage Portal Protein RA13_17005 ENOG4105IG6 Phage terminase, large subunit RA13_17010 ENOG4108TFU terminase (Small subunit) RA13_17055 ENOG410635T phage-like element pbsx protein RA13_17060 ENOG4105K7W phage-related replication protein RA13_17065 ENOG4105KWG Pfam:DUF1696 RA13_17070 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase RA13_17090 ENOG4107TSN permease RA13_17095 ENOG4105CTX dehydratase RA13_17100 ENOG4107QZW Altronate oxidoreductase RA13_17110 ENOG4105CT4 transporter RA13_17115 ENOG4105D2H Uronic isomerase RA13_17140 ENOG4105Q95 Cupin 2, conserved barrel domain protein RA13_17150 ENOG4108IXI (ABC) transporter RA13_17155 ENOG4105C4B ABC transporter, permease RA13_17160 ENOG4105EXQ uroporphyrinogen iii synthase hem4 RA13_17185 ENOG4106A3M Cytochrome p-450 RA13_17210 ENOG4108IEG Formate dehydrogenase Alpha subunit RA13_17225 ENOG4107CUJ Protein of unknown function (DUF2690) RA13_17230 ENOG4108ZJ4 polysaccharide deacetylase RA13_17250 ENOG4105KT7 mgtC SapB transporter RA13_17255 ENOG4105WFK nuclease RA13_17310 ENOG4106BHF RA13_17325 ENOG4105JHY Membrane RA13_17335 ENOG4105C28 cystathionine RA13_17340 ENOG4105C28 cystathionine RA13_17350 ENOG4108ZMI UPF0477 protein RA13_17380 ENOG4105ENA helicase RA13_17430 ENOG4107A88 RA13_17435 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH RA13_17440 ENOG4105DWF phosphomethylpyrimidine kinase RA13_17445 ENOG4105D06 uba thif-type nad fad binding protein RA13_17450 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) RA13_17465 ENOG4108VEU Thiamine monophosphate synthase RA13_17470 ENOG4105ETU transcriptional activator (TenA RA13_17485 ENOG4107S1Q Phosphatase RA13_17490 ENOG4105EMS pseudouridine synthase RA13_17495 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) RA13_17510 ENOG4105MIX Adenylate cyclase RA13_17515 ENOG4105E4C Lytic transglycosylase catalytic RA13_17520 ENOG4108Z18 K06886 hemoglobin RA13_17525 ENOG4105T58 Dithiol-disulfide isomerase RA13_17535 ENOG4105DPN Oligoendopeptidase f RA13_17545 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis RA13_17550 ENOG4108ZCF integral membrane protein RA13_17555 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) RA13_17575 ENOG4108JQ7 (ABC) transporter RA13_17585 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component RA13_17590 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component RA13_17595 ENOG4108J59 Extracellular solute-binding protein, family 5 RA13_17605 ENOG4105C31 Tryptophanyl-tRNA synthetase RA13_17615 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component RA13_17630 ENOG4108JQ7 (ABC) transporter RA13_17635 ENOG4105C3U ABC transporter RA13_17645 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) RA13_17650 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) RA13_17665 ENOG4107RMD Basic membrane lipoprotein RA13_17690 ENOG4105DBV ornithine carbamoyltransferase RA13_17700 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain RA13_17705 ENOG4105C8Y Acetylornithine aminotransferase RA13_17720 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase RA13_17730 ENOG4105IQ5 FAD linked oxidase domain protein RA13_17740 ENOG4105VG1 fes assembly suf system protein RA13_17750 ENOG4108KP7 hydrolase RA13_17755 ENOG41073B9 RA13_17765 ENOG4107AYK membrAne RA13_17770 ENOG4105EPR degv family RA13_17775 ENOG410751J RA13_17785 ENOG4105QNR S1 RNA binding domain protein RA13_17790 ENOG4108VPT UPF0234 protein RA13_17800 ENOG4105MA6 gCN5-related N-acetyltransferase RA13_17805 ENOG4108SZE gCN5-related N-acetyltransferase RA13_17810 ENOG4107RCC Major Facilitator Superfamily RA13_17815 ENOG4105DIA mandelate racemase muconate lactonizing RA13_17825 ENOG41061P3 phosphosulfolactate synthase RA13_17835 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) RA13_17840 ENOG4107RIQ Sulfate adenylate transferase RA13_17845 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) RA13_17860 ENOG4105MYW Pentapeptide repeat protein RA13_17875 ENOG4105SF0 DinB family RA13_17880 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) RA13_17885 ENOG4105ETE Transcriptional regulator (LacI family RA13_17890 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) RA13_17895 ENOG4106HBX Transcriptional Regulator AraC Family RA13_17900 ENOG4105UQX Mate efflux family protein RA13_17910 ENOG4105CAQ asparagine synthetase RA13_17930 ENOG4105ERH Fumarylacetoacetate hydrolase RA13_17985 ENOG4105EYH Exonuclease RA13_17995 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation RA13_18010 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding RA13_18015 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) RA13_18020 ENOG4106K7D Major facilitator family transporter RA13_18025 ENOG4108KK1 membrane protein AbrB duplication RA13_18030 ENOG4108INS Transcriptional regulator RA13_18035 ENOG4107SCK Monooxygenase RA13_18050 ENOG41060YP RA13_18055 ENOG4106CAD Protein of unknown function (DUF3311) RA13_18060 ENOG4105E1V na solute symporter RA13_18065 ENOG4105X3H Excalibur domain protein RA13_18070 ENOG4105XVF Competence transcription factor RA13_18090 ENOG4106YBV Methyl-accepting chemotaxis RA13_18100 ENOG41060WC Enoyl-CoA hydratase RA13_18105 ENOG4105C26 Dehydrogenase RA13_18110 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase RA13_18115 ENOG4105C1G acyl-Coa dehydrogenase RA13_18130 ENOG4107TB6 phosphoglycerate mutase RA13_18135 ENOG4108U1V ABC transporter, permease RA13_18140 ENOG4105DQ5 transport system permease protein RA13_18145 ENOG4108HUF Transporter RA13_18155 ENOG4105KD7 acetyltransferase RA13_18160 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin RA13_18165 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 RA13_18185 ENOG4105DF9 Lipoate-protein, ligase RA13_18190 ENOG4108RQ5 Beta-lactamase domain-containing protein RA13_18195 ENOG4106AXD RA13_18205 ENOG4105DER m42 family RA13_18220 ENOG4105ECB domain protein RA13_18230 ENOG4105C1Q protoporphyrinogen oxidase RA13_18240 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) RA13_18245 ENOG4105BZ4 penicillin-binding protein RA13_18250 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation RA13_18280 ENOG4105K59 histidine triad (HIT) protein RA13_18285 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) RA13_18290 ENOG4105NBU tryptophan transport protein RA13_18340 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) RA13_18350 ENOG4105EQI Metal Dependent Phosphohydrolase RA13_18355 ENOG4106D4I domain protein RA13_18360 ENOG4107VRP DNA repair exonuclease RA13_18365 ENOG4105RHA ABC transporter, permease RA13_18370 ENOG4108IUX (ABC) transporter RA13_18380 ENOG4105CGU Enoyl-CoA hydratase RA13_18390 ENOG4105NCW Trka-c domain protein RA13_18395 ENOG4107S91 Sodium hydrogen exchanger RA13_18405 ENOG4105D4P Coproporphyrinogen iii oxidase RA13_18420 ENOG4105WZB UPF0342 protein RA13_18425 ENOG4106MP8 UPF0754 membrane protein RA13_18440 ENOG410839P RA13_18465 ENOG4105BZ1 (ABC) transporter RA13_18470 ENOG4105BZ1 (ABC) transporter RA13_18485 ENOG4105F0I Aminotransferase RA13_18490 ENOG4107VMI polysaccharide deacetylase RA13_18495 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) RA13_18500 ENOG4105D64 Mechanosensitive ion channel RA13_18510 ENOG4108QXE glycerophosphoryl diester phosphodiesterase RA13_18515 ENOG4105WMR Protein CrcB homolog RA13_18525 ENOG4105C37 (CBS) domain RA13_18540 ENOG4105C37 (CBS) domain RA13_18545 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) RA13_18550 ENOG4107VFR oxidoreductase RA13_18555 ENOG4105F6E Acyl-transferase RA13_18560 ENOG4108FN7 Aldo keto reductase RA13_18565 ENOG4108AEY RNA polymerase sigma factor RA13_18570 ENOG4105J37 RA13_18580 ENOG4105D82 Glutamate dehydrogenase RA13_18585 ENOG4105C26 Dehydrogenase RA13_18620 ENOG4105CUB amino acid RA13_18625 ENOG4105CYX Short-chain dehydrogenase reductase Sdr RA13_18630 ENOG4105BZN citrate synthase RA13_18645 ENOG4105G6Z alkaline phosphatase RA13_18650 ENOG4105ED1 spovr family RA13_18685 ENOG4105WH1 Two component transcriptional regulator luxr family RA13_18690 ENOG4105BZU Histidine kinase RA13_18700 ENOG4105C6V Glycerol-3-phosphate dehydrogenase RA13_18705 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) RA13_18715 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator RA13_18720 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) RA13_18730 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase RA13_18735 ENOG4107YBY Hydrolase RA13_18740 ENOG41080XP Cbs domain RA13_18750 ENOG4108YBP pseudouridine synthase RA13_18765 ENOG4105BZU Histidine kinase RA13_18795 ENOG4105BZU Histidine kinase RA13_18810 ENOG4105VEQ Cold shock protein RA13_18815 ENOG4108TU7 Inherit from COG: (ABC) transporter RA13_18820 ENOG4105CJ1 ABC, transporter RA13_18825 ENOG4105CZV ABC transporter RA13_18830 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family RA13_18845 ENOG4105CS1 NAD(P)H quinone oxidoreductase RA13_18850 ENOG4105C0R drug resistance transporter emrb qaca subfamily RA13_18855 ENOG4105CW7 secretion protein, HlyD family RA13_18860 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes RA13_18865 ENOG4106AKX UPF0229 protein RA13_18870 ENOG4105CYN Serine protein kinase RA13_18890 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) RA13_18900 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) RA13_18915 ENOG4105VZ8 Transcriptional regulator RA13_18920 ENOG4107D63 RA13_18925 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) RA13_18935 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component RA13_18940 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein RA13_18960 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) RA13_18970 ENOG4108N23 SpoOM-related protein RA13_19090 ENOG4105TUA UPF0295 protein RA13_19095 ENOG4105G5W regulator Fur family RA13_19100 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen RA13_19110 ENOG4107NBY Membrane RA13_19115 ENOG4105BZ1 (ABC) transporter RA13_19120 ENOG4105EVI UPF0374 protein RA13_19135 ENOG4105CAN Short-chain dehydrogenase reductase Sdr RA13_19140 ENOG4106BXE RA13_19145 ENOG4105CEN a g-specific adenine glycosylase RA13_19150 ENOG41067AE Membrane-bound metal-dependent hydrolase RA13_19155 ENOG4105EJV Membrane RA13_19160 ENOG4105CKK Glycosyl transferase, family 2 RA13_19165 ENOG4105D74 hydrolase RA13_19170 ENOG4106AKJ RA13_19190 ENOG4105F27 Major Facilitator RA13_19205 ENOG4105ECP epimerase RA13_19220 ENOG4107Y03 Nitroreductase RA13_19225 ENOG4105JAB phenazine biosynthesis protein, phzf family RA13_19230 ENOG4108IHU transport system permease protein RA13_19235 ENOG4105DQ5 transport system permease protein RA13_19240 ENOG4108MES Periplasmic binding protein RA13_19250 ENOG410834F Transcriptional regulator RA13_19255 ENOG4105C0R drug resistance transporter emrb qaca subfamily RA13_19260 ENOG4108YYS metal-dependent hydrolase (By similarity) RA13_19265 ENOG4105CIS alcohol dehydrogenase RA13_19275 ENOG4105H93 Acyltransferase family RA13_19280 ENOG4105U3E Transcriptional regulator RA13_19285 ENOG4108KYE ABC-2 type transporter RA13_19295 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase RA13_19305 ENOG4105BZ1 (ABC) transporter RA13_19310 ENOG4105BZ1 (ABC) transporter RA13_19320 ENOG4105CI1 PTS System RA13_19325 ENOG4108Q3X Transcriptional regulator RA13_19330 ENOG4105F8D glycoside hydrolase family 4 RA13_19355 ENOG4105KK4 UPF0060 membrane protein RA13_19360 ENOG41069DP small acid-soluble spore protein RA13_19365 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family RA13_19375 ENOG4107QKR Dehydrogenase RA13_19385 ENOG4107RUY (E1 component), alpha subunit RA13_19400 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) RA13_19415 ENOG4105D7N magnesium and cobalt transport protein CorA RA13_19425 ENOG4106KE4 Dehydrogenase RA13_19445 ENOG4105D8X mechanosensitive ion channel RA13_19455 ENOG4105UPD Calcium Proton RA13_19460 ENOG4108ISG Major Facilitator RA13_19465 ENOG4107U9T Pfam:Ribonuclease_BN RA13_19475 ENOG4105KJF protein tyrosine phosphatase RA13_19490 ENOG4105FF2 Type I DHQase RA13_19495 ENOG4105E2X shikimate dehydrogenase RA13_19505 ENOG4105ETE Transcriptional regulator (LacI family RA13_19510 ENOG4107RKG DJ-1/PfpI family RA13_19515 ENOG4105CGH 5'-nucleotidase RA13_19520 ENOG4108RCM Nitroreductase RA13_19525 ENOG4107414 GntR family transcriptional regulator RA13_19530 ENOG4105CG3 alpha amylase, catalytic region RA13_19535 ENOG4105C5Y PTS System RA13_19580 ENOG4108RPX mosc domain containing protein RA13_19585 ENOG410855V Acylphosphatase RA13_19610 ENOG4108MRH transcriptional regulatory protein RA13_19620 ENOG4107QPK )-transporter RA13_19630 ENOG4108J20 pectate lyase RA13_19645 ENOG4108HUF Transporter RA13_19650 ENOG4105DQ5 transport system permease protein RA13_19655 ENOG4108U1V ABC transporter, permease RA13_19660 ENOG4105E0A ABC, transporter RA13_19665 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein RA13_19670 ENOG4105FDU atp-dependent rna helicase RA13_19675 ENOG4105C5H ABC transporter RA13_19685 ENOG4105DXB Major Facilitator superfamily RA13_19690 ENOG4107SWG transcriptional regulator MERR family RA13_19695 ENOG4105C5H ABC transporter RA13_19700 ENOG4106WTF Glycosyl transferase, family 2 RA13_19705 ENOG4105FKZ Methyl-accepting chemotaxis RA13_19710 ENOG4105C26 Dehydrogenase RA13_19715 ENOG4105CUB amino acid RA13_19720 ENOG4105EU0 Major facilitator Superfamily RA13_19725 ENOG41090R9 glycosyltransferase RA13_19730 ENOG4107R51 Glycosyl transferase, family 2 RA13_19735 ENOG41090R9 glycosyltransferase RA13_19745 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase RA13_19750 ENOG4105E0M Sulfatase RA13_19760 ENOG4105CJ1 ABC, transporter RA13_19775 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) RA13_19780 ENOG4108R1P RA13_19785 ENOG4106I4J membrane RA13_19805 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily RA13_19810 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) RA13_19815 ENOG4105H67 Protein of unknown function (DUF421) RA13_19820 ENOG4105F8D glycoside hydrolase family 4 RA13_19825 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component RA13_19835 ENOG4105E0S extracellular solute-binding protein family 1 RA13_19840 ENOG4105EKC RA13_19850 ENOG4107TDE lipolytic protein G-D-S-L family RA13_19855 ENOG4105CPC Aldo Keto reductase RA13_19860 ENOG4105CX8 fg-gap repeat protein RA13_19865 ENOG4105CX8 fg-gap repeat protein RA13_19880 ENOG4107TDE lipolytic protein G-D-S-L family RA13_19885 ENOG41075H3 AraC family transcriptional regulator RA13_19890 ENOG4105F5H Glycosyl Hydrolase Family 88 RA13_19900 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component RA13_19905 ENOG410769Z extracellular solute-binding protein family 1 RA13_19910 ENOG4105EQD regulatoR RA13_19930 ENOG4105M18 -acetyltransferase RA13_19935 ENOG4105WEF catalase RA13_19955 ENOG4105CDY transcriptional regulatory protein RA13_19970 ENOG4106BHF RA13_20020 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) RA13_20025 ENOG4105CBD Diacylglycerol kinase RA13_20035 ENOG4108IG5 Transcriptional regulator RA13_20040 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) RA13_20045 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) RA13_20050 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) RA13_20055 ENOG4105CK7 Sodium proline symporter RA13_20060 ENOG4105KT7 mgtC SapB transporter RA13_20065 ENOG4105CRN Aminoglycoside phosphotransferase RA13_20075 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) RA13_20080 ENOG4105C4R Atp-dependent dna helicase RA13_20085 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) RA13_20090 ENOG4105CBC glutamate synthase RA13_20095 ENOG4105KGF protein, YerC YecD RA13_20100 ENOG4108R5T secreted protein RA13_20115 ENOG4105DVH amino acid RA13_20125 ENOG4105C12 Phosphoribosylglycinamide synthetase RA13_20130 ENOG4105DC1 bifunctional purine biosynthesis protein purh RA13_20135 ENOG4108V3E phosphoribosylglycinamide formyltransferase RA13_20140 ENOG4105CXB phosphoribosylaminoimidazole synthetase RA13_20150 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii RA13_20155 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I RA13_20160 ENOG4105VR9 phosphoribosylformylglycinamidine synthase RA13_20165 ENOG4105C8V SAICAR synthetase RA13_20170 ENOG4105C83 adenylosuccinate lyase RA13_20175 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit RA13_20180 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) RA13_20205 ENOG4105C7N Xanthine uracil vitamin C permease RA13_20220 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) RA13_20235 ENOG4105C7R Atpase associated with various cellular activities aaa_3 RA13_20250 ENOG4105C85 amino acid RA13_20255 ENOG4107STQ Multicopper oxidase RA13_20265 ENOG4107YUH hydrolase RA13_20290 ENOG4107QNK )-transporter RA13_20295 ENOG4105FS7 Transcriptional regulator RA13_20300 ENOG4108TVJ Nitroreductase RA13_20310 ENOG4105JVQ RNA Polymerase RA13_20315 ENOG4108P49 AntiSigma factor RA13_20325 ENOG4108WV1 Pfam:DUF477 RA13_20330 ENOG4105DQX Zinc finger domain RA13_20335 ENOG41087YS Phage shock protein A RA13_20350 ENOG4105CPQ Dehydrogenase RA13_20355 ENOG4105PGZ NB-ARC domain RA13_20370 ENOG4105ED2 Beta-lactamase RA13_20390 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) RA13_20395 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) RA13_20400 ENOG4108TYN CAAX amino terminal protease family protein RA13_20410 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) RA13_20415 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) RA13_20420 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) RA13_20425 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) RA13_20430 ENOG4105C5H ABC transporter RA13_20435 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) RA13_20440 ENOG410801F ribosomal-protein-alanine acetyltransferase RA13_20445 ENOG41072GX Peptidase M22 Glycoprotease RA13_20450 ENOG4105K8N protein family UPF0079, ATPase RA13_20455 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) RA13_20500 ENOG4108NGU Transcriptional regulator RA13_20515 ENOG4105DJ2 Major Facilitator Superfamily RA13_20520 ENOG4105JXH GntR family transcriptional regulator RA13_20525 ENOG4105F27 Major Facilitator RA13_20550 ENOG4105E90 ABC transporter RA13_20555 ENOG4108IJ8 ABC transporter RA13_20570 ENOG4105G6Z alkaline phosphatase RA13_20590 ENOG4105VRS hydrolase family 18 RA13_20600 ENOG4105C2C drug resistance transporter, Bcr CflA RA13_20610 ENOG4108HWY Beta-lactamase RA13_20625 ENOG4108VQT Alpha beta hydrolase fold protein RA13_20640 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein RA13_20660 ENOG4105DG6 mannose-6-phosphate isomerase RA13_20665 ENOG4105DM4 PTS System RA13_20675 ENOG4105EYF MMPL domain protein RA13_20680 ENOG41062A4 Transcriptional regulator RA13_20690 ENOG4105E1V na solute symporter RA13_20700 ENOG4108UXE Protein tyrosine phosphatase RA13_20705 ENOG4107R5R arsenical pump membrane protein RA13_20710 ENOG41082YX Transcriptional regulator, arsr family RA13_20715 ENOG41085FC arsR family transcriptional regulator RA13_20725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family RA13_20730 ENOG4105T38 integral membrane protein RA13_20750 ENOG4105JAB phenazine biosynthesis protein, phzf family RA13_20770 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 RA13_20775 ENOG4108U05 Transcriptional regulator RA13_20785 ENOG4105UNS Pfam:DUF419 RA13_20790 ENOG4108VJ1 Transcriptional regulator (CarD family RA13_20795 ENOG4105VEQ Cold shock protein RA13_20805 ENOG4105ECK Fatty Acid Desaturase RA13_20810 ENOG4108HH4 Major Facilitator Superfamily RA13_20815 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein RA13_20845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family RA13_20850 ENOG4105US7 Histidine kinase RA13_20860 ENOG4108ZJ4 polysaccharide deacetylase RA13_20895 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) RA13_20900 ENOG4105KME endoribonuclease L-psp RA13_20920 ENOG4106ANW SMI1_KNR4 RA13_20985 ENOG41064BQ Phosphatase RA13_20995 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) RA13_21000 ENOG4105WN5 stage II sporulation protein RA13_21005 ENOG4107SGM protein serine threonine phosphatase RA13_21010 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase RA13_21015 ENOG4105FUA antagonist RA13_21020 ENOG4107MMM Anti-sigma-factor antagonist RA13_21025 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) RA13_21035 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) RA13_21040 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein RA13_21045 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) RA13_21055 ENOG4105CKV Membrane RA13_21060 ENOG410905X membrane-flanked domain protein RA13_21065 ENOG4105C1J atp-dependent rna helicase RA13_21075 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) RA13_21080 ENOG4105CPF Cell wall formation (By similarity) RA13_21085 ENOG4105SZ6 Thioredoxin RA13_21105 ENOG4105FDT acyl-CoA dehydrogenase RA13_21120 ENOG4105CJ1 ABC, transporter RA13_21125 ENOG4106F5Q Membrane RA13_21130 ENOG4107QJT sodium dicarboxylate symporter RA13_21135 ENOG4108MRH transcriptional regulatory protein RA13_21140 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism RA13_21145 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit RA13_21160 ENOG41082W1 Cupin 2, conserved barrel domain protein RA13_21165 ENOG4105QVS general stress protein RA13_21170 ENOG4105EU9 RA13_21175 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) RA13_21180 ENOG4107BMA Transglycosylase associated protein RA13_21185 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) RA13_21225 ENOG4105C0X amino acid RA13_21270 ENOG4105VCH membrane RA13_21285 ENOG410606W general stress protein RA13_21295 ENOG4105CYX Short-chain dehydrogenase reductase Sdr RA13_21310 ENOG4105ETD TRANSCRIPTIONal RA13_21315 ENOG4107QM2 Aldo Keto reductase RA13_21320 ENOG4107RVG penicillin-binding protein RA13_21325 ENOG41061CK Antibiotic biosynthesis monooxygenase RA13_21340 ENOG4107258 Transcriptional regulator RA13_21350 ENOG4105P4J Allophanate hydrolase, subunit 1 RA13_21355 ENOG4105CFM UPF0317 protein RA13_21360 ENOG4105C5A transporter RA13_21365 ENOG4105E7W lamb ycsf family protein RA13_21415 ENOG4108ZYE Transcriptional regulator RA13_21420 ENOG4108T5E Copper resistance protein RA13_21425 ENOG4105KTB nuclear export factor GLE1 RA13_21430 ENOG4105H9W Short-chain dehydrogenase reductase Sdr RA13_21440 ENOG4105C26 Dehydrogenase RA13_21445 ENOG4108JPW Aminotransferase RA13_21455 ENOG4105YVS arsR family transcriptional regulator RA13_21460 ENOG41067V3 Antibiotic biosynthesis monooxygenase RA13_21465 ENOG4108DBC nitroreductase RA13_21470 ENOG410780I phosphoprotein phosphatase activity RA13_21475 ENOG4105R8C Transcriptional regulator RA13_21490 ENOG4108IPW abc transporter atp-binding protein RA13_21495 ENOG4105CM4 permease protein RA13_21500 ENOG4105DHS permease protein RA13_21505 ENOG4105CFH Aspartokinase RA13_21530 ENOG4105BZU Histidine kinase RA13_21540 ENOG4107WD8 ABC transporter, permease RA13_21550 ENOG4108PGP mmge prpd family protein RA13_21555 ENOG4105CH2 amidohydrolase RA13_21565 ENOG4108HW4 amino acid AbC transporter RA13_21570 ENOG4105EAB amino acid AbC transporter RA13_21575 ENOG4108XSB acetyltransferase, (GNAT) family RA13_21580 ENOG4105CPU Monooxygenase RA13_21610 ENOG4105DUX Transporter RA13_21620 ENOG41069ZX RA13_21625 ENOG41069ZX RA13_21630 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) RA13_21635 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase RA13_21640 ENOG4106P55 Transcriptional regulator RA13_21655 ENOG4105CDA abc transporter atp-binding protein RA13_21675 ENOG4105SX7 Transporter RA13_21700 ENOG4105CEY Amp-dependent synthetase and ligase RA13_21705 ENOG4105KVH Transcriptional regulator RA13_21710 ENOG4108VA3 3-hexulose-6-phosphate synthase RA13_21715 ENOG41080HJ 6-phospho 3-hexuloisomerase RA13_21720 ENOG4105C8Q Methyl-accepting chemotaxis RA13_21735 ENOG4105CS2 ec 3.2.1.21 RA13_21755 ENOG4105HHM rdd domain containing protein RA13_21765 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein RA13_21770 ENOG4105E5Q amino acid AbC transporter RA13_21775 ENOG4105CKI cobalamin synthesis protein RA13_21780 ENOG4105S7A ErfK ybiS ycfS ynhG family protein RA13_21800 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) RA13_21805 ENOG4108IFG nitrite reductase, (NAD(P)H) RA13_21810 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit RA13_21815 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) RA13_21830 ENOG4108PJD permease RA13_21840 ENOG4107YHD transcriptional regulator RA13_21845 ENOG4105CK7 Sodium proline symporter RA13_21850 ENOG4105C26 Dehydrogenase RA13_21860 ENOG410756H nucleotidyltransferase RA13_21865 ENOG4105I82 acetyl xylan esterase RA13_21875 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) RA13_21880 ENOG4108WBH protein TIM barrel RA13_21885 ENOG4105I1F Resistance protein RA13_21890 ENOG4107RA1 nh(3)-dependent nad( ) synthetase RA13_21895 ENOG4105EIG urea carboxylase-associated protein 1 RA13_21930 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)