locus-tag	class	description
RA13_00010	COG1288	antiporter activity
RA13_00020	COG2113	Glycine betaine
RA13_00025	COG4176	ABC-type proline glycine betaine transport system permease component
RA13_00035	COG0477	Major facilitator Superfamily
RA13_00040	COG3853	Toxic anion resistance protein (TelA)
RA13_00065	COG0861	Integral membrane protein TerC family
RA13_00070	COG2310	stress, protein
RA13_00075	COG2310	stress, protein
RA13_00080	COG2310	stress, protein
RA13_00085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RA13_00090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RA13_00095	COG1121	(ABC) transporter
RA13_00100	COG0803	Belongs to the bacterial solute-binding protein 9 family
RA13_00105	COG0366	Alpha amylase catalytic
RA13_00110	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_00115	COG0457	Tetratricopeptide repeat
RA13_00120	COG1876	peptidase activity
RA13_00125	COG1595	DNA-templated transcription, initiation
RA13_00130	COG0735	belongs to the Fur family
RA13_00145	COG0667	Aldo Keto reductase
RA13_00150	COG3012	SEC-C Motif Domain Protein
RA13_00150	COG1405	negative regulation of cell septum assembly
RA13_00155	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
RA13_00160	COG0252	asparaginase activity
RA13_00165	COG1309	transcriptional regulator
RA13_00170	COG0477	Major facilitator Superfamily
RA13_00175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RA13_00185	COG0805	protein transport
RA13_00190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RA13_00195	COG3540	Alkaline phosphatase
RA13_00200	COG3773	Cell wall hydrolase
RA13_00225	COG1131	(ABC) transporter
RA13_00230	COG2205	protein histidine kinase activity
RA13_00235	COG0745	RESPONSE REGULATOR receiver
RA13_00255	COG2721	sulfolactate sulfo-lyase activity
RA13_00260	COG2186	Transcriptional regulator
RA13_00265	COG4948	Mandelate Racemase Muconate Lactonizing
RA13_00270	COG2271	Major facilitator Superfamily
RA13_00275	COG1012	belongs to the aldehyde dehydrogenase family
RA13_00280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RA13_00285	COG0784	Response regulator, receiver
RA13_00290	COG4191	Histidine kinase
RA13_00295	COG2066	Belongs to the glutaminase family
RA13_00300	COG1115	amino acid carrier protein
RA13_00305	COG2040	homocysteine
RA13_00315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RA13_00330	COG0363	glucosamine-6-phosphate deaminase activity
RA13_00335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RA13_00335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RA13_00335	COG2190	(PTS) system
RA13_00335	COG1263	PTS System
RA13_00335	COG2190	(PTS) system
RA13_00335	COG1263	PTS System
RA13_00340	COG1301	dicarboxylic acid transport
RA13_00350	COG2207	Transcriptional regulator
RA13_00360	COG1404	Belongs to the peptidase S8 family
RA13_00375	COG0688	phosphatidylethanolamine metabolic process
RA13_00380	COG0586	Pfam SNARE associated Golgi protein
RA13_00385	COG1183	phosphatidylcholine synthase activity
RA13_00400	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RA13_00405	COG0371	Dehydrogenase
RA13_00410	COG0697	spore germination
RA13_00415	COG3409	Peptidoglycan-binding domain 1 protein
RA13_00440	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RA13_00450	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RA13_00450	COG1215	transferase activity, transferring glycosyl groups
RA13_00455	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RA13_00455	COG1215	transferase activity, transferring glycosyl groups
RA13_00465	COG2271	Major facilitator Superfamily
RA13_00470	COG0584	glycerophosphoryl diester phosphodiesterase
RA13_00475	COG1283	sodium-dependent phosphate transmembrane transporter activity
RA13_00485	COG2124	cytochrome p450
RA13_00490	COG2602	Beta-lactamase
RA13_00505	COG1113	amino acid transport
RA13_00510	COG1846	Transcriptional regulator
RA13_00515	COG1380	Effector of murein hydrolase LrgA
RA13_00520	COG1346	cytolysis
RA13_00530	COG0642	Histidine kinase
RA13_00535	COG0745	RESPONSE REGULATOR receiver
RA13_00540	COG0596	Alpha beta hydrolase
RA13_00545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RA13_00550	COG2808	Putative FMN-binding domain
RA13_00555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RA13_00565	COG0076	glutamate decarboxylase activity
RA13_00590	COG1413	lyase activity
RA13_00620	COG0640	Transcriptional regulator
RA13_00625	COG5609	conserved protein (DUF2294)
RA13_00635	COG0288	reversible hydration of carbon dioxide
RA13_00655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RA13_00660	COG4856	YbbR-like protein
RA13_00665	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
RA13_00670	COG5662	AntiSigma factor
RA13_00675	COG1595	DNA-templated transcription, initiation
RA13_00705	COG1683	Conserved Protein
RA13_00710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RA13_00715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
RA13_00720	COG1737	Transcriptional regulator
RA13_00725	COG1263	PTS System
RA13_00725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RA13_00730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RA13_00735	COG1472	Belongs to the glycosyl hydrolase 3 family
RA13_00740	COG3876	Protein conserved in bacteria
RA13_00745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RA13_00745	COG2207	Transcriptional regulator
RA13_00750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RA13_00755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RA13_00760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RA13_00765	COG2819	hydrolase of the alpha beta superfamily
RA13_00770	COG0385	Bile acid
RA13_00775	COG0659	secondary active sulfate transmembrane transporter activity
RA13_00780	COG1063	alcohol dehydrogenase
RA13_00795	COG0738	Major facilitator superfamily
RA13_00825	COG0726	polysaccharide deacetylase
RA13_00830	COG2194	sulfuric ester hydrolase activity
RA13_00840	COG0489	protein tyrosine kinase activity
RA13_00845	COG0860	N-Acetylmuramoyl-L-alanine amidase
RA13_00865	COG2226	methyltransferase
RA13_00875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RA13_00885	COG0101	tRNA pseudouridine synthase activity
RA13_00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RA13_00895	COG1122	ATPase activity
RA13_00900	COG1122	ATPase activity
RA13_00905	COG0203	ribosomal protein L17
RA13_00915	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RA13_00920	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RA13_00925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RA13_00930	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RA13_00935	COG2163	COG2163 Ribosomal protein L14E L6E L27E
RA13_00940	COG0024	Methionine aminopeptidase
RA13_00950	COG0201	protein transport
RA13_00960	COG1841	ribosomal large subunit assembly
RA13_00965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RA13_00970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RA13_00980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RA13_01005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RA13_01010	COG0255	Belongs to the universal ribosomal protein uL29 family
RA13_01015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RA13_01025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RA13_01030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RA13_01035	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RA13_01040	COG0089	rRNA binding
RA13_01050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RA13_01055	COG0051	transcription antitermination factor activity, RNA binding
RA13_01060	COG0596	Alpha beta hydrolase
RA13_01070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RA13_01075	COG0049	tRNA binding
RA13_01085	COG1358	cellular component organization or biogenesis
RA13_01095	COG0085	RNA polymerase activity
RA13_01100	COG2813	Specifically methylates the guanine in position
RA13_01105	COG0222	ribosome binding
RA13_01110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RA13_01120	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RA13_01125	COG0250	Participates in transcription elongation, termination and antitermination
RA13_01130	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RA13_01135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RA13_01140	COG1595	DNA-templated transcription, initiation
RA13_01145	COG3688	RNA-binding protein containing a PIN domain
RA13_01150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RA13_01155	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
RA13_01160	COG0215	cysteine-tRNA ligase activity
RA13_01170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RA13_01175	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RA13_01180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RA13_01185	COG4956	integral membrane protein (PIN domain superfamily)
RA13_01190	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
RA13_01195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RA13_01200	COG0542	response to heat
RA13_01205	COG3869	Catalyzes the specific phosphorylation of arginine residues in
RA13_01210	COG3880	PFAM UvrB UvrC protein
RA13_01215	COG4463	regulation of RNA biosynthetic process
RA13_01295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RA13_01300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RA13_01305	COG1396	sequence-specific DNA binding
RA13_01310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RA13_01315	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RA13_01320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RA13_01325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RA13_01330	COG0512	Glutamine amidotransferase of anthranilate synthase
RA13_01335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RA13_01340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RA13_01345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RA13_01360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RA13_01370	COG0037	tRNA processing
RA13_01375	COG0515	serine threonine protein kinase
RA13_01380	COG2304	oxidoreductase activity
RA13_01385	COG2208	phosphoserine phosphatase activity
RA13_01400	COG1098	S1 RNA binding domain
RA13_01405	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RA13_01420	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RA13_01425	COG3956	TIGRFAM MazG family protein
RA13_01430	COG2244	polysaccharide biosynthetic process
RA13_01435	COG2002	toxin-antitoxin pair type II binding
RA13_01440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RA13_01455	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RA13_01460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RA13_01475	COG0251	oxidation-reduction process
RA13_01480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RA13_01485	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RA13_01495	COG4466	Protein conserved in bacteria
RA13_01505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RA13_01510	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
RA13_01515	COG3583	domain protein
RA13_01515	COG3584	3D domain protein
RA13_01525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RA13_01525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RA13_01530	COG2002	toxin-antitoxin pair type II binding
RA13_01535	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RA13_01540	COG2827	Endonuclease containing a URI domain
RA13_01545	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
RA13_01555	COG1774	PSP1 C-terminal conserved region
RA13_01560	COG0470	DNA polymerase III
RA13_01565	COG1728	Protein conserved in bacteria
RA13_01570	COG3870	Protein conserved in bacteria
RA13_01575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RA13_01585	COG3853	Toxic anion resistance protein (TelA)
RA13_01590	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
RA13_01635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RA13_01640	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RA13_01645	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RA13_01655	COG0590	tRNA wobble adenosine to inosine editing
RA13_01660	COG1335	isochorismatase
RA13_01665	COG3858	chitin binding
RA13_01665	COG1388	LysM domain
RA13_01670	COG1428	Deoxynucleoside kinase
RA13_01675	COG1428	Deoxynucleoside kinase
RA13_01700	COG1686	Belongs to the peptidase S11 family
RA13_01705	COG0516	GMP reductase activity
RA13_01705	COG0517	IMP dehydrogenase activity
RA13_01775	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RA13_01780	COG0187	DNA topoisomerase II activity
RA13_01790	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RA13_01795	COG2501	S4 domain
RA13_01800	COG0592	DNA-directed DNA polymerase activity
RA13_01805	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RA13_01810	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RA13_01815	COG0594	ribonuclease P activity
RA13_01820	COG0706	membrane insertase activity
RA13_01825	COG1847	R3H domain protein
RA13_01835	COG0445	tRNA wobble uridine modification
RA13_01845	COG1475	DNA binding
RA13_01855	COG1192	Involved in chromosome partitioning
RA13_01860	COG1475	DNA binding
RA13_01870	COG3949	Membrane
RA13_01875	COG4481	Protein conserved in bacteria
RA13_01880	COG0243	molybdopterin cofactor binding
RA13_01885	COG0012	GTP binding
RA13_01890	COG0360	Binds together with S18 to 16S ribosomal RNA
RA13_01895	COG0629	single-stranded DNA binding
RA13_01910	COG1802	Transcriptional regulator
RA13_01915	COG0697	spore germination
RA13_01920	COG0708	Exodeoxyribonuclease III
RA13_01925	COG2169	Transcriptional regulator
RA13_01935	COG1609	Transcriptional regulator
RA13_01940	COG0346	lactoylglutathione lyase activity
RA13_01950	COG1331	Highly conserved protein containing a thioredoxin domain
RA13_01960	COG2856	Zn peptidase
RA13_01975	COG2205	protein histidine kinase activity
RA13_01980	COG0745	RESPONSE REGULATOR receiver
RA13_02000	COG4585	Histidine kinase
RA13_02005	COG2197	response regulator
RA13_02010	COG2409	Drug exporters of the RND superfamily
RA13_02020	COG4978	Transcriptional regulator
RA13_02020	COG0789	Transcriptional regulator
RA13_02025	COG1802	Transcriptional regulator
RA13_02030	COG0473	3-isopropylmalate dehydrogenase activity
RA13_02040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RA13_02045	COG2271	Major facilitator Superfamily
RA13_02060	COG1733	regulation of RNA biosynthetic process
RA13_02065	COG5577	PFAM Coat F domain
RA13_02075	COG4241	membrane
RA13_02080	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
RA13_02085	COG0359	binds to the 23S rRNA
RA13_02090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RA13_02095	COG2807	transmembrane transport
RA13_02100	COG3093	addiction module antidote protein HigA
RA13_02115	COG0305	Participates in initiation and elongation during chromosome replication
RA13_02120	COG0346	lactoylglutathione lyase activity
RA13_02150	COG0745	RESPONSE REGULATOR receiver
RA13_02155	COG5002	protein histidine kinase activity
RA13_02160	COG4863	YycH protein
RA13_02165	COG4853	Protein conserved in bacteria
RA13_02170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RA13_02175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RA13_02195	COG0488	(ABC) transporter
RA13_02205	COG3829	transcription factor binding
RA13_02210	COG0640	Transcriptional regulator
RA13_02215	COG5658	integral membrane protein
RA13_02220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RA13_02225	COG0833	amino acid
RA13_02230	COG0010	Belongs to the arginase family
RA13_02235	COG0456	acetyltransferase
RA13_02240	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
RA13_02255	COG1063	alcohol dehydrogenase
RA13_02265	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RA13_02295	COG2003	Belongs to the UPF0758 family
RA13_02360	COG2323	membrane
RA13_02365	COG0038	chloride channel
RA13_02370	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
RA13_02375	COG1131	(ABC) transporter
RA13_02395	COG1113	amino acid transport
RA13_02405	COG3634	alkyl hydroperoxide reductase activity
RA13_02410	COG0450	alkyl hydroperoxide reductase
RA13_02425	COG2610	gluconate transmembrane transporter activity
RA13_02430	COG1070	Carbohydrate kinase
RA13_02435	COG1802	Transcriptional regulator
RA13_02440	COG3835	regulator
RA13_02445	COG2610	gluconate transmembrane transporter activity
RA13_02450	COG1929	Belongs to the glycerate kinase type-1 family
RA13_02455	COG5039	Polysaccharide pyruvyl transferase
RA13_02490	COG1309	transcriptional regulator
RA13_02495	COG1917	Cupin 2, conserved barrel domain protein
RA13_02500	COG2311	Membrane
RA13_02505	COG1714	RDD family
RA13_02515	COG1012	belongs to the aldehyde dehydrogenase family
RA13_02520	COG1309	transcriptional regulator
RA13_02525	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_02530	COG0326	Molecular chaperone. Has ATPase activity
RA13_02535	COG2814	Major facilitator Superfamily
RA13_02555	COG0667	Aldo Keto reductase
RA13_02560	COG1349	DNA-binding transcription factor activity
RA13_02575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RA13_02580	COG3962	Belongs to the TPP enzyme family
RA13_02585	COG1082	Xylose isomerase domain protein TIM barrel
RA13_02590	COG2814	Major facilitator Superfamily
RA13_02595	COG0673	inositol 2-dehydrogenase activity
RA13_02600	COG1082	Xylose isomerase domain protein TIM barrel
RA13_02615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RA13_02625	COG0745	RESPONSE REGULATOR receiver
RA13_02630	COG2205	protein histidine kinase activity
RA13_02635	COG1136	(ABC) transporter
RA13_02640	COG0577	efflux transmembrane transporter activity
RA13_02645	COG5294	Protein conserved in bacteria
RA13_02670	COG0561	phosphatase activity
RA13_02675	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
RA13_02685	COG3192	ethanolamine utilization protein
RA13_02695	COG2390	Transcriptional regulator
RA13_02700	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RA13_02705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RA13_02710	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RA13_02720	COG0010	Belongs to the arginase family
RA13_02725	COG1228	amidohydrolase
RA13_02730	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RA13_02735	COG2986	histidine ammonia-lyase
RA13_02795	COG3507	Belongs to the glycosyl hydrolase 43 family
RA13_02805	COG1181	Belongs to the D-alanine--D-alanine ligase family
RA13_02820	COG3977	Valine--pyruvate aminotransferase
RA13_02825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RA13_02825	COG1263	PTS System
RA13_02825	COG2190	(PTS) system
RA13_02830	COG2723	6-phospho-beta-galactosidase activity
RA13_02835	COG0589	response to stress
RA13_02865	COG0697	spore germination
RA13_02945	COG2755	lipolytic protein G-D-S-L family
RA13_02945	COG3401	FG-GAP repeat protein
RA13_02950	COG1357	PFAM Pentapeptide repeats (8 copies)
RA13_02960	COG0513	Belongs to the DEAD box helicase family
RA13_02965	COG2270	Major facilitator Superfamily
RA13_02975	COG3711	transcriptional antiterminator
RA13_02985	COG2851	Citrate transporter
RA13_02990	COG0693	protein deglycase activity
RA13_02990	COG0753	catalase activity
RA13_03005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RA13_03010	COG0500	methyltransferase
RA13_03015	COG2610	gluconate transmembrane transporter activity
RA13_03020	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RA13_03025	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RA13_03030	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_03035	COG3290	protein histidine kinase activity
RA13_03035	COG3829	transcription factor binding
RA13_03040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RA13_03045	COG4894	glucomannan catabolic process
RA13_03060	COG2195	Cleaves the N-terminal amino acid of tripeptides
RA13_03070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RA13_03080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RA13_03090	COG2508	Transcriptional regulator
RA13_03095	COG3842	ATPase activity
RA13_03100	COG0726	polysaccharide deacetylase
RA13_03110	COG3493	citrate carrier protein
RA13_03115	COG1271	oxidase subunit
RA13_03120	COG1294	oxidase, subunit
RA13_03125	COG4988	ABC transporter
RA13_03130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RA13_03135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RA13_03140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
RA13_03145	COG1595	DNA-templated transcription, initiation
RA13_03165	COG1131	(ABC) transporter
RA13_03170	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
RA13_03175	COG2814	Major facilitator Superfamily
RA13_03180	COG0753	catalase activity
RA13_03185	COG2094	Belongs to the DNA glycosylase MPG family
RA13_03190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RA13_03190	COG3711	transcriptional antiterminator
RA13_03195	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RA13_03200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RA13_03205	COG1447	Phosphotransferase system cellobiose-specific component IIA
RA13_03210	COG1486	melibiose metabolic process
RA13_03215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RA13_03220	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
RA13_03230	COG1696	Membrane protein involved in D-alanine export
RA13_03235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA13_03245	COG0569	domain protein
RA13_03255	COG2357	RelA SpoT domain protein
RA13_03260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RA13_03265	COG1846	Transcriptional regulator
RA13_03270	COG0457	Tetratricopeptide repeat
RA13_03275	COG2234	aminopeptidase activity
RA13_03280	COG5522	Integral membrane protein (intg_mem_TP0381)
RA13_03285	COG1442	glycosyl transferase family 8
RA13_03290	COG3711	transcriptional antiterminator
RA13_03295	COG1263	PTS System
RA13_03295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RA13_03310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RA13_03315	COG0346	lactoylglutathione lyase activity
RA13_03320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RA13_03325	COG4895	conserved protein (DUF2196)
RA13_03355	COG1131	(ABC) transporter
RA13_03360	COG1346	cytolysis
RA13_03365	COG1380	Effector of murein hydrolase LrgA
RA13_03370	COG0583	DNA-binding transcription factor activity
RA13_03375	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
RA13_03380	COG0352	thiamine-phosphate diphosphorylase activity
RA13_03385	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
RA13_03390	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RA13_03395	COG3162	membrane
RA13_03415	COG1309	transcriptional regulator
RA13_03420	COG2246	polysaccharide biosynthetic process
RA13_03425	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RA13_03430	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
RA13_03435	COG2261	transglycosylase associated protein
RA13_03440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RA13_03445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RA13_03455	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RA13_03470	COG0772	Belongs to the SEDS family
RA13_03475	COG0778	Nitroreductase
RA13_03480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RA13_03495	COG3711	transcriptional antiterminator
RA13_03510	COG1621	beta-fructofuranosidase activity
RA13_03525	COG0351	phosphomethylpyrimidine kinase
RA13_03530	COG1695	Transcriptional regulator
RA13_03545	COG1216	Glycosyl transferase, family 2
RA13_03550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RA13_03555	COG1012	belongs to the aldehyde dehydrogenase family
RA13_03565	COG2233	PERMEase
RA13_03570	COG2363	Small membrane protein
RA13_03580	COG0463	Glycosyl transferase, family 2
RA13_03585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RA13_03590	COG0456	acetyltransferase
RA13_03595	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RA13_03600	COG1088	dTDP-glucose 4,6-dehydratase activity
RA13_03610	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
RA13_03620	COG2814	Major facilitator Superfamily
RA13_03625	COG2814	Major facilitator Superfamily
RA13_03635	COG0280	phosphate acetyltransferase
RA13_03645	COG0583	DNA-binding transcription factor activity
RA13_03650	COG0095	Lipoate-protein ligase
RA13_03655	COG0697	spore germination
RA13_03665	COG4844	belongs to the
RA13_03670	COG1078	dGTPase activity
RA13_03675	COG3465	dGTPase activity
RA13_03680	COG0531	amino acid
RA13_03685	COG1846	Transcriptional regulator
RA13_03690	COG1942	4-Oxalocrotonate Tautomerase
RA13_03695	COG1994	Peptidase M50
RA13_03705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RA13_03710	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RA13_03715	COG0010	Belongs to the arginase family
RA13_03725	COG1131	(ABC) transporter
RA13_03755	COG0457	Tetratricopeptide repeat
RA13_03760	COG1388	LysM domain
RA13_03765	COG3391	amine dehydrogenase activity
RA13_03770	COG3391	amine dehydrogenase activity
RA13_03790	COG4506	Protein conserved in bacteria
RA13_03795	COG0018	arginyl-trna synthetase
RA13_03805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RA13_03815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RA13_03820	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RA13_03825	COG1140	nitrate reductase beta subunit
RA13_03830	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RA13_03835	COG2181	nitrate reductase activity
RA13_03840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA13_03845	COG1132	(ABC) transporter
RA13_03850	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RA13_03860	COG4294	response to UV
RA13_03865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA13_03870	COG2181	nitrate reductase activity
RA13_03870	COG0247	lactate metabolic process
RA13_03875	COG1960	acyl-CoA dehydrogenase activity
RA13_03880	COG3343	RNA polymerase activity
RA13_03885	COG0504	CTP synthase activity
RA13_03890	COG4821	SIS domain
RA13_03895	COG2204	response regulator
RA13_03900	COG0191	fructose-bisphosphate aldolase activity
RA13_03910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RA13_03915	COG1494	fructose-1,6-bisphosphatase
RA13_03920	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RA13_03925	COG0254	rRNA binding
RA13_03935	COG0281	malic enzyme
RA13_03940	COG0679	Auxin Efflux Carrier
RA13_03945	COG0789	Transcriptional regulator
RA13_03950	COG0346	lactoylglutathione lyase activity
RA13_03955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RA13_03960	COG2890	protein-(glutamine-N5) methyltransferase activity
RA13_03980	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RA13_03985	COG0009	L-threonylcarbamoyladenylate synthase
RA13_03990	COG1971	Probably functions as a manganese efflux pump
RA13_03995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RA13_04000	COG0698	ribose 5-phosphate isomerase
RA13_04005	COG4475	Protein of unknown function (DUF436)
RA13_04010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RA13_04015	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RA13_04030	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RA13_04035	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RA13_04040	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RA13_04050	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RA13_04055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RA13_04060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RA13_04070	COG4836	Membrane
RA13_04080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RA13_04085	COG2385	sporulation resulting in formation of a cellular spore
RA13_04095	COG2304	oxidoreductase activity
RA13_04100	COG2304	oxidoreductase activity
RA13_04110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RA13_04120	COG0457	Tetratricopeptide repeat
RA13_04125	COG1994	Peptidase M50
RA13_04130	COG3237	CsbD-like
RA13_04135	COG0831	urea catabolic process
RA13_04145	COG0804	urea catabolic process
RA13_04150	COG1959	2 iron, 2 sulfur cluster binding
RA13_04155	COG2910	NAD(P)H-binding
RA13_04165	COG0789	Transcriptional regulator
RA13_04170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RA13_04180	COG2089	acid synthase
RA13_04195	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
RA13_04200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RA13_04205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RA13_04210	COG1086	Polysaccharide biosynthesis protein
RA13_04220	COG1247	-acetyltransferase
RA13_04225	COG0739	heme binding
RA13_04235	COG0671	phosphoesterase, PA-phosphatase related
RA13_04240	COG0772	Belongs to the SEDS family
RA13_04245	COG0347	Belongs to the P(II) protein family
RA13_04250	COG0004	ammonium transporteR
RA13_04260	COG1335	isochorismatase
RA13_04265	COG0477	Major facilitator Superfamily
RA13_04270	COG1953	Uracil, thiamine, allantoin
RA13_04275	COG2814	Major facilitator Superfamily
RA13_04280	COG1846	Transcriptional regulator
RA13_04290	COG1609	Transcriptional regulator
RA13_04295	COG1077	Cell shape determining protein MreB Mrl
RA13_04300	COG4786	Flagellar basal body rod
RA13_04305	COG4786	Flagellar basal body rod
RA13_04310	COG0457	Tetratricopeptide repeat
RA13_04320	COG1970	mechanosensitive ion channel activity
RA13_04335	COG0629	single-stranded DNA binding
RA13_04340	COG1349	DNA-binding transcription factor activity
RA13_04345	COG0561	phosphatase activity
RA13_04350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RA13_04355	COG4715	Zinc finger, swim domain protein
RA13_04365	COG3944	biosynthesis protein
RA13_04370	COG0489	protein tyrosine kinase activity
RA13_04375	COG4464	protein tyrosine phosphatase activity
RA13_04380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RA13_04400	COG5444	nuclease activity
RA13_04405	COG2849	repeat protein
RA13_04435	COG0583	DNA-binding transcription factor activity
RA13_04440	COG0655	NAD(P)H dehydrogenase (quinone) activity
RA13_04450	COG2059	Chromate
RA13_04455	COG2059	Chromate
RA13_04460	COG1522	sequence-specific DNA binding
RA13_04465	COG0405	Gamma-glutamyltransferase
RA13_04475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RA13_04490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RA13_04495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RA13_04505	COG5337	Spore coat protein CotH
RA13_04520	COG3527	Alpha-acetolactate decarboxylase
RA13_04525	COG2249	NAD(P)H dehydrogenase (quinone) activity
RA13_04535	COG3103	Sh3 type 3 domain protein
RA13_04540	COG1879	ABC-type sugar transport system periplasmic component
RA13_04545	COG1172	Belongs to the binding-protein-dependent transport system permease family
RA13_04550	COG1129	ABC transporter
RA13_04555	COG1869	D-ribose catabolic process
RA13_04560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RA13_04565	COG1609	Transcriptional regulator
RA13_04575	COG0531	amino acid
RA13_04580	COG0697	spore germination
RA13_04585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RA13_04595	COG2843	Capsule synthesis protein
RA13_04605	COG0791	NLP P60 protein
RA13_04610	COG0561	phosphatase activity
RA13_04615	COG1316	TRANSCRIPTIONal
RA13_04620	COG2814	Major facilitator Superfamily
RA13_04625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RA13_04635	COG0814	amino acid
RA13_04640	COG0697	spore germination
RA13_04645	COG1482	cell wall glycoprotein biosynthetic process
RA13_04650	COG4193	domain, Protein
RA13_04655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RA13_04660	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
RA13_04665	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RA13_04675	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RA13_04680	COG1682	transport, permease protein
RA13_04685	COG1134	teichoic acid transport
RA13_04690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RA13_04695	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RA13_04700	COG1316	TRANSCRIPTIONal
RA13_04710	COG2385	sporulation resulting in formation of a cellular spore
RA13_04710	COG2247	cell wall binding repeat
RA13_04715	COG0860	N-Acetylmuramoyl-L-alanine amidase
RA13_04715	COG2247	cell wall binding repeat
RA13_04735	COG0297	glycogen (starch) synthase activity
RA13_04735	COG0438	transferase activity, transferring glycosyl groups
RA13_04740	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RA13_04745	COG3307	-O-antigen
RA13_04750	COG3206	protein involved in exopolysaccharide biosynthesis
RA13_04755	COG1215	transferase activity, transferring glycosyl groups
RA13_04760	COG0438	transferase activity, transferring glycosyl groups
RA13_04765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RA13_04770	COG1316	TRANSCRIPTIONal
RA13_04775	COG1739	Uncharacterized protein family UPF0029
RA13_04780	COG4585	Histidine kinase
RA13_04785	COG2197	response regulator
RA13_04790	COG1307	EDD domain protein, DegV family
RA13_04795	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
RA13_04805	COG1040	competence protein
RA13_04815	COG2747	anti-sigma28 factor FlgM
RA13_04820	COG3418	PFAM FlgN family protein
RA13_04825	COG1256	bacterial-type flagellum assembly
RA13_04825	COG4786	Flagellar basal body rod
RA13_04830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RA13_04840	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
RA13_04845	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
RA13_04850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RA13_04855	COG1334	flagellar protein FlaG
RA13_04860	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RA13_04865	COG1516	flagellar protein fliS
RA13_04880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RA13_04885	COG0653	protein targeting
RA13_04895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RA13_04900	COG2010	Cytochrome c
RA13_04905	COG2884	Cell division ATP-binding protein ftsE
RA13_04910	COG2177	Part of the ABC transporter FtsEX involved in
RA13_04915	COG3409	Peptidoglycan-binding domain 1 protein
RA13_04915	COG0793	Belongs to the peptidase S41A family
RA13_04925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RA13_04935	COG2814	Major facilitator Superfamily
RA13_04940	COG1309	transcriptional regulator
RA13_04945	COG3848	Pyruvate phosphate dikinase
RA13_04945	COG0574	Belongs to the PEP-utilizing enzyme family
RA13_04950	COG4897	Protein conserved in bacteria
RA13_04960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RA13_04975	COG3595	metallopeptidase activity
RA13_04980	COG1983	PspC domain protein
RA13_04985	COG1950	PFAM Membrane protein of
RA13_04990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RA13_05005	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RA13_05010	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RA13_05015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RA13_05020	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RA13_05025	COG0546	phosphoglycolate phosphatase activity
RA13_05030	COG0110	maltose O-acetyltransferase activity
RA13_05035	COG5297	Belongs to the glycosyl hydrolase family 6
RA13_05040	COG4990	cell redox homeostasis
RA13_05050	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RA13_05055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RA13_05060	COG0131	Imidazoleglycerol-phosphate dehydratase
RA13_05070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RA13_05075	COG0107	imidazoleglycerol-phosphate synthase activity
RA13_05080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RA13_05080	COG0140	phosphoribosyl-ATP diphosphatase activity
RA13_05085	COG1247	-acetyltransferase
RA13_05105	COG0457	Tetratricopeptide repeat
RA13_05110	COG3883	PFAM NLP P60 protein
RA13_05110	COG0791	NLP P60 protein
RA13_05115	COG0492	ferredoxin-NADP+ reductase activity
RA13_05120	COG1051	belongs to the nudix hydrolase family
RA13_05125	COG1660	Displays ATPase and GTPase activities
RA13_05130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RA13_05140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RA13_05145	COG2162	N-hydroxyarylamine O-acetyltransferase activity
RA13_05150	COG4290	ribonuclease
RA13_05155	COG0745	RESPONSE REGULATOR receiver
RA13_05160	COG5002	protein histidine kinase activity
RA13_05165	COG1136	(ABC) transporter
RA13_05170	COG0577	efflux transmembrane transporter activity
RA13_05175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RA13_05185	COG0659	secondary active sulfate transmembrane transporter activity
RA13_05190	COG1694	Mazg nucleotide pyrophosphohydrolase
RA13_05195	COG1611	Belongs to the LOG family
RA13_05220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RA13_05225	COG2076	Multidrug Resistance protein
RA13_05230	COG2076	Multidrug Resistance protein
RA13_05235	COG1309	transcriptional regulator
RA13_05250	COG1621	beta-fructofuranosidase activity
RA13_05270	COG1131	(ABC) transporter
RA13_05285	COG2272	Belongs to the type-B carboxylesterase lipase family
RA13_05290	COG1396	sequence-specific DNA binding
RA13_05295	COG3944	biosynthesis protein
RA13_05300	COG0489	protein tyrosine kinase activity
RA13_05305	COG1086	Polysaccharide biosynthesis protein
RA13_05310	COG0438	transferase activity, transferring glycosyl groups
RA13_05315	COG1215	transferase activity, transferring glycosyl groups
RA13_05320	COG0438	transferase activity, transferring glycosyl groups
RA13_05330	COG1216	Glycosyl transferase, family 2
RA13_05335	COG5039	Polysaccharide pyruvyl transferase
RA13_05340	COG1216	Glycosyl transferase, family 2
RA13_05345	COG2244	polysaccharide biosynthetic process
RA13_05350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RA13_05355	COG0110	maltose O-acetyltransferase activity
RA13_05360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RA13_05365	COG5039	Polysaccharide pyruvyl transferase
RA13_05375	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RA13_05385	COG2186	Transcriptional regulator
RA13_05390	COG2208	phosphoserine phosphatase activity
RA13_05395	COG0247	lactate metabolic process
RA13_05400	COG1139	Iron-sulfur cluster binding protein
RA13_05405	COG1556	Lactate utilization protein
RA13_05415	COG1113	amino acid transport
RA13_05420	COG0697	spore germination
RA13_05425	COG0583	DNA-binding transcription factor activity
RA13_05430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RA13_05435	COG1609	Transcriptional regulator
RA13_05440	COG2814	Major facilitator Superfamily
RA13_05445	COG2390	Transcriptional regulator
RA13_05450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RA13_05455	COG0126	phosphoglycerate kinase activity
RA13_05465	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
RA13_05475	COG2234	aminopeptidase activity
RA13_05485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RA13_05490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RA13_05510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RA13_05525	COG0456	acetyltransferase
RA13_05530	COG4640	response to antibiotic
RA13_05535	COG3064	Membrane
RA13_05545	COG1510	regulation of RNA biosynthetic process
RA13_05550	COG0517	IMP dehydrogenase activity
RA13_05550	COG1125	glycine betaine transport
RA13_05555	COG1174	glycine betaine transport
RA13_05560	COG1732	Glycine betaine
RA13_05565	COG1174	glycine betaine transport
RA13_05570	COG1510	regulation of RNA biosynthetic process
RA13_05575	COG1125	glycine betaine transport
RA13_05575	COG0517	IMP dehydrogenase activity
RA13_05585	COG1732	Glycine betaine
RA13_05590	COG1174	glycine betaine transport
RA13_05595	COG0840	transmembrane signaling receptor activity
RA13_05600	COG1733	regulation of RNA biosynthetic process
RA13_05605	COG1396	sequence-specific DNA binding
RA13_05610	COG1396	sequence-specific DNA binding
RA13_05615	COG1476	TRANSCRIPTIONal
RA13_05620	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RA13_05625	COG1647	Serine aminopeptidase, S33
RA13_05630	COG0557	exoribonuclease II activity
RA13_05635	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RA13_05650	COG0673	inositol 2-dehydrogenase activity
RA13_05655	COG1937	Protein conserved in bacteria
RA13_05660	COG2608	mercury ion transmembrane transporter activity
RA13_05665	COG2217	Heavy metal translocating P-type atpase
RA13_05670	COG2217	Heavy metal translocating P-type atpase
RA13_05675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RA13_05680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RA13_05690	COG2860	membrane
RA13_05695	COG3973	AAA domain
RA13_05700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RA13_05725	COG0656	L-ascorbic acid biosynthetic process
RA13_05735	COG4149	molybdate abc transporter
RA13_05740	COG0725	ABC transporter, periplasmic molybdate-binding protein
RA13_05745	COG1910	domain protein
RA13_05750	COG1368	sulfuric ester hydrolase activity
RA13_05755	COG1988	membrane-bound metal-dependent
RA13_05770	COG0531	amino acid
RA13_05780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RA13_05785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RA13_05790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RA13_05795	COG1120	ATPase activity
RA13_05800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RA13_05805	COG1136	(ABC) transporter
RA13_05810	COG0577	efflux transmembrane transporter activity
RA13_05820	COG2140	Oxalate decarboxylase
RA13_05830	COG1191	sigma factor activity
RA13_05840	COG0745	RESPONSE REGULATOR receiver
RA13_05845	COG2205	protein histidine kinase activity
RA13_05850	COG3386	PFAM SMP-30 Gluconolaconase
RA13_05855	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_05860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RA13_05865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RA13_05870	COG1120	ATPase activity
RA13_05875	COG2096	Adenosyltransferase
RA13_05880	COG2814	Major facilitator Superfamily
RA13_05885	COG4758	membrane
RA13_05890	COG1842	Phage shock protein A
RA13_05895	COG3595	metallopeptidase activity
RA13_05900	COG4758	membrane
RA13_05905	COG4585	Histidine kinase
RA13_05910	COG2197	response regulator
RA13_05935	COG0114	fumarate hydratase activity
RA13_05940	COG1309	transcriptional regulator
RA13_05950	COG2205	protein histidine kinase activity
RA13_05950	COG2770	Histidine kinase
RA13_05955	COG0745	RESPONSE REGULATOR receiver
RA13_05960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RA13_05965	COG0783	Belongs to the Dps family
RA13_05970	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_05985	COG1120	ATPase activity
RA13_05995	COG0477	Major facilitator Superfamily
RA13_06000	COG1846	Transcriptional regulator
RA13_06005	COG5577	PFAM Coat F domain
RA13_06025	COG1250	3-hydroxyacyl-CoA dehydrogenase
RA13_06025	COG1024	Enoyl-CoA hydratase
RA13_06030	COG0183	Belongs to the thiolase family
RA13_06035	COG1960	acyl-CoA dehydrogenase activity
RA13_06040	COG1393	Belongs to the ArsC family
RA13_06045	COG0509	glycine decarboxylation via glycine cleavage system
RA13_06055	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
RA13_06060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RA13_06070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RA13_06075	COG2011	ABC-type metal ion transport system permease component
RA13_06080	COG1464	Belongs to the NlpA lipoprotein family
RA13_06085	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RA13_06090	COG0396	ATPase activity
RA13_06095	COG0719	Fe-S assembly protein
RA13_06100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RA13_06105	COG0822	iron-sulfur transferase activity
RA13_06110	COG0719	Fe-S assembly protein
RA13_06115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RA13_06120	COG0322	excinuclease ABC activity
RA13_06125	COG2222	sugar isomerase
RA13_06130	COG1653	transport
RA13_06135	COG1175	transmembrane transport
RA13_06140	COG0395	ABC-type sugar transport system, permease component
RA13_06145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RA13_06150	COG2188	Transcriptional regulator
RA13_06155	COG3842	ATPase activity
RA13_06165	COG2356	endonuclease I
RA13_06170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RA13_06175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RA13_06180	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RA13_06195	COG2814	Major facilitator Superfamily
RA13_06210	COG1131	(ABC) transporter
RA13_06265	COG1595	DNA-templated transcription, initiation
RA13_06275	COG2508	Transcriptional regulator
RA13_06280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RA13_06295	COG1801	Protein of unknown function DUF72
RA13_06300	COG0730	response to heat
RA13_06305	COG0737	Belongs to the 5'-nucleotidase family
RA13_06310	COG3377	Domain of unknown function (DUF1805)
RA13_06320	COG0739	heme binding
RA13_06335	COG4470	Protein conserved in bacteria
RA13_06340	COG2445	Protein of unknown function DUF86
RA13_06345	COG0647	UMP catabolic process
RA13_06350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RA13_06355	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RA13_06360	COG0460	homoserine dehydrogenase
RA13_06365	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RA13_06370	COG0083	homoserine kinase activity
RA13_06375	COG0823	Involved in the tonB-independent uptake of proteins
RA13_06375	COG1506	peptidase
RA13_06375	COG4946	Tricorn protease homolog
RA13_06380	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RA13_06385	COG4837	Protein of unknown function (DUF1462)
RA13_06390	COG3479	Phenolic acid decarboxylase
RA13_06395	COG1252	NADH dehydrogenase
RA13_06400	COG4844	belongs to the
RA13_06405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RA13_06410	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RA13_06415	COG0316	Belongs to the HesB IscA family
RA13_06420	COG0516	GMP reductase activity
RA13_06435	COG1252	NADH dehydrogenase
RA13_06450	COG3584	3D domain protein
RA13_06455	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
RA13_06460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RA13_06465	COG2056	Na+-H+ antiporter family
RA13_06470	COG1268	BioY protein
RA13_06475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RA13_06490	COG2819	hydrolase of the alpha beta superfamily
RA13_06495	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_06500	COG1169	isochorismate synthase
RA13_06510	COG3433	isochorismatase activity
RA13_06510	COG1535	isochorismatase
RA13_06515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA13_06520	COG3251	PFAM MbtH domain protein
RA13_06525	COG5634	Uncharacterized conserved protein (DUF2278)
RA13_06530	COG0686	Belongs to the AlaDH PNT family
RA13_06535	COG2508	Transcriptional regulator
RA13_06535	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
RA13_06540	COG4842	Belongs to the WXG100 family
RA13_06545	COG5417	Belongs to the EsaB family
RA13_06550	COG4499	WXG100 protein secretion system (Wss), protein YukC
RA13_06555	COG1674	ftsk spoiiie
RA13_06555	COG0433	COG0433 Predicted ATPase
RA13_06560	COG1511	domain protein
RA13_06570	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_06575	COG1418	mRNA catabolic process
RA13_06585	COG0628	permease
RA13_06600	COG5506	Protein of unknown function (DUF1694)
RA13_06605	COG1335	isochorismatase
RA13_06610	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RA13_06615	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
RA13_06630	COG0142	geranyltranstransferase activity
RA13_06640	COG4585	Histidine kinase
RA13_06645	COG2197	response regulator
RA13_06650	COG2050	protein possibly involved in aromatic compounds catabolism
RA13_06655	COG1320	monovalent cation:proton antiporter activity
RA13_06660	COG2212	antiporter activity
RA13_06665	COG1863	multisubunit Na H antiporter MnhE subunit
RA13_06670	COG0651	ATP synthesis coupled electron transport
RA13_06675	COG1006	Multisubunit Na H antiporter MnhC subunit
RA13_06680	COG2111	Na H antiporter
RA13_06695	COG3493	citrate carrier protein
RA13_06720	COG4565	transcriptional regulatory protein
RA13_06725	COG3290	protein histidine kinase activity
RA13_06735	COG3011	Protein conserved in bacteria
RA13_06740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RA13_06745	COG2814	Major facilitator Superfamily
RA13_06755	COG5018	Exonuclease
RA13_06765	COG2205	protein histidine kinase activity
RA13_06770	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RA13_06780	COG2267	carboxylic ester hydrolase activity
RA13_06785	COG1522	sequence-specific DNA binding
RA13_06790	COG0436	Aminotransferase
RA13_06795	COG1098	S1 RNA binding domain
RA13_06800	COG2155	Conserved Protein
RA13_06805	COG1979	alcohol dehydrogenase
RA13_06810	COG1979	alcohol dehydrogenase
RA13_06815	COG0166	Belongs to the GPI family
RA13_06830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RA13_06845	COG2738	Putative neutral zinc metallopeptidase
RA13_06850	COG1253	flavin adenine dinucleotide binding
RA13_06860	COG0432	Pfam Uncharacterised protein family UPF0047
RA13_06865	COG2070	2-Nitropropane dioxygenase
RA13_06880	COG0840	transmembrane signaling receptor activity
RA13_06885	COG0840	transmembrane signaling receptor activity
RA13_06890	COG0840	transmembrane signaling receptor activity
RA13_06895	COG0840	transmembrane signaling receptor activity
RA13_06900	COG3347	Dehydrogenase
RA13_06900	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_06905	COG1349	DNA-binding transcription factor activity
RA13_06910	COG1070	Carbohydrate kinase
RA13_06915	COG3254	rhamnose metabolic process
RA13_06920	COG4806	L-rhamnose isomerase
RA13_06925	COG0693	protein deglycase activity
RA13_06930	COG0673	inositol 2-dehydrogenase activity
RA13_06935	COG0628	permease
RA13_07010	COG3677	Transposase
RA13_07020	COG0477	Major facilitator Superfamily
RA13_07025	COG1705	Flagellar rod assembly protein muramidase FlgJ
RA13_07035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RA13_07040	COG0569	domain protein
RA13_07055	COG1510	regulation of RNA biosynthetic process
RA13_07065	COG1454	alcohol dehydrogenase
RA13_07075	COG2318	DinB family
RA13_07080	COG1585	Membrane protein implicated in regulation of membrane protease activity
RA13_07085	COG2268	Band 7 protein
RA13_07095	COG3764	Sortase (surface protein transpeptidase)
RA13_07100	COG3859	Proton-coupled thiamine transporter YuaJ
RA13_07225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RA13_07230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RA13_07235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RA13_07240	COG0297	glycogen (starch) synthase activity
RA13_07245	COG0058	SHG alpha-glucan phosphorylase activity
RA13_07250	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
RA13_07255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RA13_07260	COG0438	transferase activity, transferring glycosyl groups
RA13_07265	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RA13_07275	COG0438	transferase activity, transferring glycosyl groups
RA13_07280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RA13_07290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RA13_07295	COG1169	isochorismate synthase
RA13_07300	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
RA13_07305	COG0596	Alpha beta hydrolase
RA13_07310	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RA13_07315	COG0318	PFAM AMP-dependent synthetase and ligase
RA13_07320	COG4948	Mandelate Racemase Muconate Lactonizing
RA13_07325	COG0803	Belongs to the bacterial solute-binding protein 9 family
RA13_07330	COG1121	(ABC) transporter
RA13_07335	COG1321	iron dependent repressor
RA13_07335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RA13_07340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RA13_07345	COG4305	rare lipoprotein A
RA13_07355	COG1294	oxidase, subunit
RA13_07360	COG1271	oxidase subunit
RA13_07370	COG0523	cobalamin synthesis protein
RA13_07375	COG0288	reversible hydration of carbon dioxide
RA13_07380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RA13_07400	COG0783	Belongs to the Dps family
RA13_07405	COG4824	toxin secretion phage lysis holin
RA13_07415	COG0494	nUDIX hydrolase
RA13_07420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA13_07425	COG1116	anion transmembrane transporter activity
RA13_07430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RA13_07435	COG1506	peptidase
RA13_07445	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RA13_07455	COG0367	asparagine synthase
RA13_07460	COG1113	amino acid transport
RA13_07465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RA13_07470	COG2267	carboxylic ester hydrolase activity
RA13_07480	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
RA13_07495	COG1725	Transcriptional regulator
RA13_07500	COG1131	(ABC) transporter
RA13_07510	COG1136	(ABC) transporter
RA13_07515	COG0577	efflux transmembrane transporter activity
RA13_07520	COG0745	RESPONSE REGULATOR receiver
RA13_07525	COG2205	protein histidine kinase activity
RA13_07530	COG1136	(ABC) transporter
RA13_07535	COG0577	efflux transmembrane transporter activity
RA13_07540	COG2433	Pfam Transposase IS66
RA13_07545	COG2814	Major facilitator Superfamily
RA13_07550	COG1366	Belongs to the anti-sigma-factor antagonist family
RA13_07550	COG2202	Pas domain
RA13_07560	COG0495	leucyl-tRNA aminoacylation
RA13_07565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RA13_07575	COG1073	alpha beta
RA13_07580	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
RA13_07585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RA13_07590	COG0156	8-amino-7-oxononanoate synthase activity
RA13_07600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RA13_07605	COG2124	cytochrome p450
RA13_07610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RA13_07615	COG0395	ABC-type sugar transport system, permease component
RA13_07620	COG1653	transport
RA13_07625	COG2207	Transcriptional regulator
RA13_07630	COG4209	transmembrane transport
RA13_07635	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
RA13_07640	COG1653	transport
RA13_07645	COG0673	inositol 2-dehydrogenase activity
RA13_07650	COG5578	integral membrane protein
RA13_07660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RA13_07665	COG2081	HI0933 family
RA13_07670	COG2244	polysaccharide biosynthetic process
RA13_07675	COG1187	pseudouridine synthase activity
RA13_07680	COG1349	DNA-binding transcription factor activity
RA13_07685	COG2252	PERMEase
RA13_07690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RA13_07695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RA13_07700	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
RA13_07710	COG1597	lipid kinase activity
RA13_07715	COG1523	belongs to the glycosyl hydrolase 13 family
RA13_07720	COG0510	thiamine kinase activity
RA13_07730	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RA13_07735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RA13_07740	COG0281	malic enzyme
RA13_07745	COG5584	Small secreted protein
RA13_07760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RA13_07765	COG4848	Belongs to the UPF0354 family
RA13_07770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RA13_07775	COG1674	ftsk spoiiie
RA13_07785	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
RA13_07790	COG4980	gas vesicle protein
RA13_07795	COG3118	belongs to the thioredoxin family
RA13_07800	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
RA13_07800	COG1605	Chorismate mutase
RA13_07805	COG1609	Transcriptional regulator
RA13_07810	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RA13_07815	COG1360	Flagellar Motor Protein
RA13_07820	COG0123	including yeast histone deacetylase and acetoin utilization protein
RA13_07825	COG0517	IMP dehydrogenase activity
RA13_07830	COG0454	-acetyltransferase
RA13_07835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RA13_07845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RA13_07850	COG0583	DNA-binding transcription factor activity
RA13_07865	COG0400	carboxylic ester hydrolase activity
RA13_07875	COG0346	lactoylglutathione lyase activity
RA13_07880	COG2259	Doxx family
RA13_07900	COG1335	isochorismatase
RA13_07925	COG2203	Gaf domain
RA13_07925	COG2199	diguanylate cyclase activity
RA13_07930	COG1956	GAF domain-containing protein
RA13_07935	COG1309	transcriptional regulator
RA13_07940	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RA13_07945	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
RA13_07950	COG1114	Component of the transport system for branched-chain amino acids
RA13_07955	COG1104	cysteine desulfurase activity
RA13_07960	COG0301	tRNA thio-modification
RA13_07970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RA13_07975	COG1574	metal-dependent hydrolase with the TIM-barrel fold
RA13_07980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RA13_07985	COG0616	signal peptide processing
RA13_07990	COG1714	RDD family
RA13_08000	COG3874	Sporulation protein YtfJ
RA13_08005	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RA13_08010	COG0827	DNA restriction-modification system
RA13_08015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RA13_08020	COG0521	Mo-molybdopterin cofactor biosynthetic process
RA13_08025	COG0137	argininosuccinate synthase activity
RA13_08030	COG0165	Argininosuccinate lyase
RA13_08040	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_08045	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RA13_08050	COG4109	DRTGG domain
RA13_08060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RA13_08085	COG0281	malic enzyme
RA13_08090	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RA13_08095	COG0825	malonyl-CoA metabolic process
RA13_08105	COG0469	pyruvate kinase activity
RA13_08110	COG3030	protein affecting phage T7 exclusion by the F plasmid
RA13_08115	COG0628	permease
RA13_08120	COG2707	UPF0756 membrane protein
RA13_08125	COG0372	Belongs to the citrate synthase family
RA13_08130	COG0538	isocitrate dehydrogenase activity
RA13_08140	COG0745	RESPONSE REGULATOR receiver
RA13_08145	COG5002	protein histidine kinase activity
RA13_08150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RA13_08150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RA13_08155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RA13_08160	COG1971	Probably functions as a manganese efflux pump
RA13_08165	COG0237	dephospho-CoA kinase activity
RA13_08170	COG0656	L-ascorbic acid biosynthetic process
RA13_08175	COG2814	Major facilitator Superfamily
RA13_08180	COG1733	regulation of RNA biosynthetic process
RA13_08185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RA13_08190	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
RA13_08195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RA13_08200	COG3611	Membrane attachment protein
RA13_08205	COG1484	DNA-dependent DNA replication
RA13_08210	COG0398	Pfam SNARE associated Golgi protein
RA13_08220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RA13_08230	COG3275	phosphorelay sensor kinase activity
RA13_08235	COG3279	Response regulator of the LytR AlgR family
RA13_08245	COG1346	cytolysis
RA13_08265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RA13_08270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RA13_08275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RA13_08280	COG3326	Membrane
RA13_08290	COG1363	Peptidase, m42
RA13_08295	COG3507	Belongs to the glycosyl hydrolase 43 family
RA13_08320	COG2160	L-arabinose isomerase activity
RA13_08325	COG1069	ribulokinase activity
RA13_08330	COG0235	Class ii aldolase
RA13_08335	COG0647	UMP catabolic process
RA13_08340	COG0371	Dehydrogenase
RA13_08345	COG1653	transport
RA13_08350	COG1175	transmembrane transport
RA13_08355	COG0395	ABC-type sugar transport system, permease component
RA13_08360	COG3534	alpha-L-arabinofuranosidase
RA13_08365	COG1966	Carbon starvation protein
RA13_08370	COG0346	lactoylglutathione lyase activity
RA13_08375	COG0247	lactate metabolic process
RA13_08380	COG0277	FAD linked oxidase domain protein
RA13_08385	COG3835	regulator
RA13_08395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RA13_08400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RA13_08405	COG0072	phenylalanine-tRNA ligase activity
RA13_08405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RA13_08415	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
RA13_08420	COG1286	toxin biosynthetic process
RA13_08425	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RA13_08425	COG1796	DNA polymerase
RA13_08430	COG1193	negative regulation of DNA recombination
RA13_08435	COG3766	membrane
RA13_08445	COG0318	PFAM AMP-dependent synthetase and ligase
RA13_08450	COG1309	transcriptional regulator
RA13_08455	COG1024	Enoyl-CoA hydratase
RA13_08460	COG2086	electron transfer activity
RA13_08465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RA13_08470	COG3534	alpha-L-arabinofuranosidase
RA13_08475	COG3118	belongs to the thioredoxin family
RA13_08480	COG0322	excinuclease ABC activity
RA13_08485	COG0527	aspartate kinase activity
RA13_08490	COG1719	4-vinyl reductase, 4VR
RA13_08495	COG2009	succinate dehydrogenase
RA13_08500	COG1053	succinate dehydrogenase
RA13_08510	COG0824	Thioesterase
RA13_08515	COG2197	response regulator
RA13_08520	COG1846	Transcriptional regulator
RA13_08525	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RA13_08530	COG5401	PFAM Sporulation and spore germination
RA13_08535	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RA13_08540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RA13_08545	COG0622	Phosphoesterase
RA13_08555	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
RA13_08560	COG0454	-acetyltransferase
RA13_08575	COG0028	Belongs to the TPP enzyme family
RA13_08580	COG0440	acetolactate synthase activity
RA13_08585	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RA13_08590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RA13_08595	COG0473	3-isopropylmalate dehydrogenase activity
RA13_08600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RA13_08605	COG0066	3-isopropylmalate dehydratase activity
RA13_08610	COG1477	protein flavinylation
RA13_08610	COG0457	Tetratricopeptide repeat
RA13_08615	COG0544	peptidyl-prolyl cis-trans isomerase activity
RA13_08630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RA13_08645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RA13_08650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RA13_08660	COG1587	Uroporphyrinogen-III synthase
RA13_08665	COG0113	porphobilinogen synthase activity
RA13_08670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RA13_08675	COG1388	LysM domain
RA13_08680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RA13_08690	COG0525	valine-tRNA ligase activity
RA13_08695	COG0285	dihydrofolate synthase activity
RA13_08700	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RA13_08710	COG0424	maF-like protein
RA13_08715	COG2003	Belongs to the UPF0758 family
RA13_08720	COG1077	Cell shape determining protein MreB Mrl
RA13_08725	COG1792	Involved in formation and maintenance of cell shape
RA13_08730	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
RA13_08735	COG0850	regulation of cytokinetic process
RA13_08740	COG2894	cell division
RA13_08745	COG0739	heme binding
RA13_08750	COG1994	Peptidase M50
RA13_08755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RA13_08760	COG2868	ribosomal protein
RA13_08765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RA13_08770	COG3290	protein histidine kinase activity
RA13_08775	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RA13_08785	COG0077	Prephenate dehydratase
RA13_08790	COG1827	regulation of RNA biosynthetic process
RA13_08795	COG1104	cysteine desulfurase activity
RA13_08800	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RA13_08805	COG0157	Belongs to the NadC ModD family
RA13_08810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RA13_08815	COG1388	LysM domain
RA13_08830	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RA13_08835	COG1447	Phosphotransferase system cellobiose-specific component IIA
RA13_08840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RA13_08845	COG1486	melibiose metabolic process
RA13_08855	COG3394	polysaccharide catabolic process
RA13_08875	COG0217	transcriptional regulatory protein
RA13_08895	COG2112	serine threonine protein kinase
RA13_08900	COG2814	Major facilitator Superfamily
RA13_08910	COG0632	four-way junction helicase activity
RA13_08915	COG2255	four-way junction helicase activity
RA13_08925	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RA13_08935	COG1862	Preprotein translocase
RA13_08945	COG2323	membrane
RA13_08950	COG2244	polysaccharide biosynthetic process
RA13_08960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RA13_08960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RA13_08965	COG0490	domain, Protein
RA13_08970	COG5416	Lipopolysaccharide assembly protein A domain
RA13_08975	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RA13_08975	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RA13_08990	COG1490	D-aminoacyl-tRNA deacylase activity
RA13_08995	COG3103	Sh3 type 3 domain protein
RA13_08995	COG0860	N-Acetylmuramoyl-L-alanine amidase
RA13_08995	COG4991	sh3 domain protein
RA13_09010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RA13_09020	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RA13_09025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RA13_09030	COG1959	2 iron, 2 sulfur cluster binding
RA13_09035	COG1104	cysteine desulfurase activity
RA13_09045	COG0457	Tetratricopeptide repeat
RA13_09050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RA13_09055	COG3881	PFAM PRC-barrel domain
RA13_09070	COG0765	amino acid transport
RA13_09075	COG0765	amino acid transport
RA13_09080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RA13_09085	COG1126	abc transporter atp-binding protein
RA13_09090	COG0628	permease
RA13_09095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RA13_09100	COG4472	Bacterial protein of unknown function (DUF965)
RA13_09105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RA13_09110	COG3906	Belongs to the UPF0473 family
RA13_09115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RA13_09135	COG0572	uridine kinase
RA13_09140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RA13_09160	COG2226	methyltransferase
RA13_09165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RA13_09170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RA13_09175	COG0626	cystathionine gamma-synthase activity
RA13_09185	COG2427	Protein of unknown function (DUF1641)
RA13_09190	COG3383	formate dehydrogenase (NAD+) activity
RA13_09195	COG5609	conserved protein (DUF2294)
RA13_09205	COG2116	formate transmembrane transporter activity
RA13_09215	COG2226	methyltransferase
RA13_09220	COG1309	transcriptional regulator
RA13_09225	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RA13_09225	COG2124	cytochrome p450
RA13_09230	COG2176	DNA-directed DNA polymerase activity
RA13_09235	COG2814	Major facilitator Superfamily
RA13_09240	COG0583	DNA-binding transcription factor activity
RA13_09255	COG3443	Belongs to the bacterial solute-binding protein 9 family
RA13_09270	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RA13_09280	COG0583	DNA-binding transcription factor activity
RA13_09295	COG1725	Transcriptional regulator
RA13_09325	COG2732	(Barnase) inhibitor
RA13_09330	COG1309	transcriptional regulator
RA13_09365	COG1733	regulation of RNA biosynthetic process
RA13_09370	COG2085	NADP oxidoreductase coenzyme F420-dependent
RA13_09390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RA13_09435	COG0398	Pfam SNARE associated Golgi protein
RA13_09445	COG0726	polysaccharide deacetylase
RA13_09450	COG2755	lipolytic protein G-D-S-L family
RA13_09460	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
RA13_09465	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RA13_09470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RA13_09475	COG1534	Rna-binding protein
RA13_09480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RA13_09485	COG1713	HD superfamily hydrolase involved in NAD metabolism
RA13_09490	COG0799	negative regulation of ribosome biogenesis
RA13_09495	COG2226	methyltransferase
RA13_09500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RA13_09505	COG1555	photosystem II stabilization
RA13_09505	COG1596	polysaccharide export
RA13_09510	COG2131	deaminase
RA13_09515	COG0658	competence protein
RA13_09515	COG2333	competence protein COMEC
RA13_09525	COG1466	dna polymerase III delta subunit
RA13_09540	COG0860	N-Acetylmuramoyl-L-alanine amidase
RA13_09550	COG0481	GTPase activity
RA13_09555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RA13_09560	COG1420	regulation of RNA biosynthetic process
RA13_09565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RA13_09585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RA13_09590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RA13_09595	COG1283	sodium-dependent phosphate transmembrane transporter activity
RA13_09600	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RA13_09605	COG1610	YqeY-like protein
RA13_09615	COG4864	UPF0365 protein
RA13_09650	COG0561	phosphatase activity
RA13_09655	COG1702	phosphate starvation-inducible protein PhoH
RA13_09660	COG1480	7TM receptor with intracellular HD hydrolase
RA13_09670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RA13_09675	COG0295	cytidine deaminase activity
RA13_09680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RA13_09690	COG1381	Involved in DNA repair and RecF pathway recombination
RA13_09695	COG0752	glycyl-tRNA synthetase alpha subunit
RA13_09700	COG0751	glycine-tRNA ligase activity
RA13_09705	COG0517	IMP dehydrogenase activity
RA13_09710	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RA13_09715	COG1671	Belongs to the UPF0178 family
RA13_09720	COG0358	DNA primase activity
RA13_09725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RA13_09730	COG2010	Cytochrome c
RA13_09735	COG2384	SAM-dependent methyltransferase
RA13_09740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RA13_09745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RA13_09755	COG0513	Belongs to the DEAD box helicase family
RA13_09760	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
RA13_09770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RA13_09775	COG0735	belongs to the Fur family
RA13_09780	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
RA13_09785	COG4709	membrane
RA13_09795	COG1388	LysM domain
RA13_09800	COG5521	maltodextrose utilization protein MalA
RA13_09805	COG2839	Protein conserved in bacteria
RA13_09810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RA13_09815	COG0477	Major facilitator Superfamily
RA13_09825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RA13_09830	COG0573	inorganic phosphate transmembrane transporter activity
RA13_09835	COG0581	inorganic phosphate transmembrane transporter activity
RA13_09840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RA13_09845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RA13_09850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RA13_09865	COG0438	transferase activity, transferring glycosyl groups
RA13_09870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RA13_09875	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RA13_09885	COG0705	Rhomboid family
RA13_09885	COG0457	Tetratricopeptide repeat
RA13_09890	COG4483	Protein conserved in bacteria
RA13_09895	COG1940	carbohydrate kinase activity
RA13_09900	COG1368	sulfuric ester hydrolase activity
RA13_09905	COG2866	Carboxypeptidase
RA13_09915	COG0011	TIGRFAM Protein of
RA13_09925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RA13_09935	COG1393	Belongs to the ArsC family
RA13_09945	COG1366	Belongs to the anti-sigma-factor antagonist family
RA13_09950	COG1253	flavin adenine dinucleotide binding
RA13_09955	COG0598	Magnesium transport protein CorA
RA13_09965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RA13_09970	COG1459	type II secretion system
RA13_09975	COG4537	Required for transformation and DNA binding
RA13_09980	COG4970	Tfp pilus assembly protein FimT
RA13_09990	COG4940	Competence protein ComGF
RA13_10015	COG0681	Belongs to the peptidase S26 family
RA13_10025	COG1396	sequence-specific DNA binding
RA13_10040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RA13_10045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RA13_10050	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RA13_10055	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RA13_10060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RA13_10065	COG0095	Lipoate-protein ligase
RA13_10070	COG1321	iron dependent repressor
RA13_10085	COG3872	metal-dependent enzyme
RA13_10095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RA13_10100	COG0006	proline dipeptidase activity
RA13_10105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RA13_10115	COG3854	ATPases associated with a variety of cellular activities
RA13_10155	COG0511	ligase activity, forming carbon-carbon bonds
RA13_10160	COG0439	Biotin carboxylase
RA13_10165	COG1302	Protein conserved in bacteria
RA13_10170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RA13_10175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RA13_10180	COG1570	exodeoxyribonuclease VII activity
RA13_10185	COG1722	exodeoxyribonuclease VII activity
RA13_10190	COG0142	geranyltranstransferase activity
RA13_10195	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RA13_10200	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
RA13_10205	COG1438	arginine binding
RA13_10210	COG0497	DNA recombination
RA13_10215	COG0750	zinc metalloprotease
RA13_10220	COG0745	RESPONSE REGULATOR receiver
RA13_10230	COG1902	pentaerythritol trinitrate reductase activity
RA13_10240	COG0860	N-Acetylmuramoyl-L-alanine amidase
RA13_10245	COG0584	glycerophosphoryl diester phosphodiesterase
RA13_10250	COG0183	Belongs to the thiolase family
RA13_10255	COG1250	3-hydroxyacyl-CoA dehydrogenase
RA13_10260	COG1960	acyl-CoA dehydrogenase activity
RA13_10265	COG0372	Belongs to the citrate synthase family
RA13_10270	COG2079	MmgE PrpD family protein
RA13_10275	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RA13_10290	COG0280	phosphate acetyltransferase
RA13_10300	COG3426	butyrate kinase activity
RA13_10310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RA13_10315	COG0022	dehydrogenase e1 component
RA13_10320	COG0508	dehydrogenase complex catalyzes the overall conversion of
RA13_10330	COG1597	lipid kinase activity
RA13_10340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RA13_10345	COG0765	amino acid transport
RA13_10350	COG1126	abc transporter atp-binding protein
RA13_10355	COG4129	membrane
RA13_10360	COG1376	ErfK ybiS ycfS ynhG family protein
RA13_10365	COG0346	lactoylglutathione lyase activity
RA13_10370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RA13_10375	COG2195	Cleaves the N-terminal amino acid of tripeptides
RA13_10380	COG3361	conserved protein (COG2071)
RA13_10385	COG0706	membrane insertase activity
RA13_10395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RA13_10400	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RA13_10405	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RA13_10420	COG0596	Alpha beta hydrolase
RA13_10425	COG1902	pentaerythritol trinitrate reductase activity
RA13_10430	COG4187	Peptidase family M20/M25/M40
RA13_10435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RA13_10440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RA13_10445	COG0300	oxidoreductase activity
RA13_10450	COG3048	D-serine ammonia-lyase activity
RA13_10455	COG1072	(Pantothenic acid kinase))
RA13_10480	COG0628	permease
RA13_10490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RA13_10500	COG0456	acetyltransferase
RA13_10505	COG2329	Antibiotic biosynthesis monooxygenase
RA13_10510	COG0456	acetyltransferase
RA13_10510	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
RA13_10515	COG4918	Iron-sulphur cluster biosynthesis
RA13_10525	COG1073	alpha beta
RA13_10535	COG0667	Aldo Keto reductase
RA13_10545	COG0494	nUDIX hydrolase
RA13_10550	COG1379	DNA repair
RA13_10555	COG1396	sequence-specific DNA binding
RA13_10560	COG0252	asparaginase activity
RA13_10565	COG1027	Aspartate ammonia-lyase
RA13_10570	COG1757	Na H antiporter
RA13_10575	COG0281	malic enzyme
RA13_10585	COG1300	Membrane
RA13_10590	COG0735	belongs to the Fur family
RA13_10600	COG4974	Belongs to the 'phage' integrase family
RA13_10605	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RA13_10610	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RA13_10615	COG1686	Belongs to the peptidase S11 family
RA13_10620	COG1366	Belongs to the anti-sigma-factor antagonist family
RA13_10625	COG2172	sigma factor antagonist activity
RA13_10630	COG1191	sigma factor activity
RA13_10650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RA13_10665	COG0697	spore germination
RA13_10670	COG0019	diaminopimelate decarboxylase activity
RA13_10675	COG4086	secreted protein
RA13_10680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RA13_10690	COG3420	alginic acid biosynthetic process
RA13_10710	COG3833	ABC-type maltose transport systems, permease component
RA13_10715	COG1175	transmembrane transport
RA13_10720	COG2182	Extracellular solute-binding protein
RA13_10745	COG0673	inositol 2-dehydrogenase activity
RA13_10755	COG1278	Cold shock
RA13_10760	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
RA13_10765	COG0681	Belongs to the peptidase S26 family
RA13_10775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RA13_10775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RA13_10780	COG0307	riboflavin synthase, alpha
RA13_10785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RA13_10785	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RA13_10790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RA13_10795	COG0456	acetyltransferase
RA13_10800	COG1547	Domain of unknown function (DUF309)
RA13_10810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RA13_10815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RA13_10825	COG1686	Belongs to the peptidase S11 family
RA13_10830	COG2715	membrane protein required for spore maturation
RA13_10835	COG0700	Nucleoside recognition
RA13_10840	COG1187	pseudouridine synthase activity
RA13_10845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RA13_10850	COG1333	cytochrome c biogenesis protein
RA13_10855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RA13_10860	COG0745	RESPONSE REGULATOR receiver
RA13_10865	COG5002	protein histidine kinase activity
RA13_10870	COG1595	DNA-templated transcription, initiation
RA13_10880	COG0710	3-dehydroquinate dehydratase activity
RA13_10885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RA13_10890	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
RA13_10895	COG1141	Ferredoxin
RA13_10900	COG4955	Helix-turn-helix domain
RA13_10905	COG0514	ATP-dependent DNA helicase (RecQ)
RA13_10910	COG1266	CAAX protease self-immunity
RA13_10915	COG1388	LysM domain
RA13_10925	COG1408	metallophosphoesterase
RA13_10930	COG4862	establishment of competence for transformation
RA13_10935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RA13_10945	COG2339	peptidase activity
RA13_10950	COG3409	Peptidoglycan-binding domain 1 protein
RA13_10950	COG3773	Cell wall hydrolase
RA13_10955	COG2959	enzyme of heme biosynthesis
RA13_10960	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
RA13_10970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RA13_10975	COG0539	negative regulation of cytoplasmic translation
RA13_10980	COG1304	FMN binding
RA13_11005	COG1160	GTP binding
RA13_11010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RA13_11025	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
RA13_11030	COG0776	regulation of translation
RA13_11035	COG0302	gtp cyclohydrolase
RA13_11045	COG0142	geranyltranstransferase activity
RA13_11055	COG0142	geranyltranstransferase activity
RA13_11060	COG0105	UTP biosynthetic process
RA13_11065	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RA13_11080	COG4401	Chorismate mutase type I
RA13_11085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RA13_11110	COG0159	tryptophan synthase activity
RA13_11115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RA13_11120	COG0287	Prephenate dehydrogenase
RA13_11125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RA13_11130	COG0457	Tetratricopeptide repeat
RA13_11135	COG5582	Belongs to the UPF0302 family
RA13_11145	COG0723	plastoquinol--plastocyanin reductase activity
RA13_11150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RA13_11155	COG2010	Cytochrome c
RA13_11155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RA13_11160	COG4347	Protein of unknown function (DUF1405)
RA13_11170	COG2140	Oxalate decarboxylase
RA13_11175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RA13_11180	COG1694	Mazg nucleotide pyrophosphohydrolase
RA13_11195	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RA13_11200	COG0438	transferase activity, transferring glycosyl groups
RA13_11205	COG0617	tRNA 3'-terminal CCA addition
RA13_11210	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RA13_11210	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RA13_11220	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RA13_11225	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RA13_11230	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RA13_11235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RA13_11235	COG1199	ATP-dependent helicase activity
RA13_11245	COG5353	protein conserved in bacteria
RA13_11250	COG0436	Aminotransferase
RA13_11255	COG0017	Asparaginyl-tRNA synthetase
RA13_11260	COG3935	DnaD domain protein
RA13_11265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RA13_11275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RA13_11275	COG4499	WXG100 protein secretion system (Wss), protein YukC
RA13_11280	COG3331	DNA recombination
RA13_11315	COG0071	Belongs to the small heat shock protein (HSP20) family
RA13_11320	COG2190	(PTS) system
RA13_11330	COG3359	exonuclease
RA13_11355	COG0116	Belongs to the methyltransferase superfamily
RA13_11370	COG1199	ATP-dependent helicase activity
RA13_11375	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_11380	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
RA13_11385	COG1609	Transcriptional regulator
RA13_11390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RA13_11395	COG0800	Aldolase
RA13_11405	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
RA13_11410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RA13_11415	COG2233	PERMEase
RA13_11420	COG3424	synthase
RA13_11425	COG1755	Isoprenylcysteine carboxyl methyltransferase
RA13_11435	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
RA13_11450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RA13_11460	COG0328	RNA-DNA hybrid ribonuclease activity
RA13_11465	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RA13_11470	COG0328	RNA-DNA hybrid ribonuclease activity
RA13_11490	COG1278	Cold shock
RA13_11495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RA13_11500	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
RA13_11510	COG1418	mRNA catabolic process
RA13_11515	COG1413	lyase activity
RA13_11530	COG2136	Putative SAM-dependent methyltransferase
RA13_11530	COG2521	methyltransferase
RA13_11540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RA13_11550	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RA13_11555	COG0204	Acyl-transferase
RA13_11560	COG1272	protein, Hemolysin III
RA13_11565	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
RA13_11570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RA13_11580	COG1999	signal sequence binding
RA13_11585	COG2755	lipolytic protein G-D-S-L family
RA13_11590	COG4698	Protein conserved in bacteria
RA13_11600	COG0534	Mate efflux family protein
RA13_11605	COG1846	Transcriptional regulator
RA13_11610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RA13_11630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RA13_11635	COG2207	Transcriptional regulator
RA13_11635	COG3708	Transcriptional regulator
RA13_11640	COG5444	nuclease activity
RA13_11650	COG3655	Transcriptional regulator
RA13_11660	COG3397	chitin binding
RA13_11665	COG0366	Alpha amylase catalytic
RA13_11680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RA13_11685	COG0582	viral genome integration into host DNA
RA13_11690	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
RA13_11695	COG4641	Protein conserved in bacteria
RA13_11710	COG0463	Glycosyl transferase, family 2
RA13_11715	COG0456	acetyltransferase
RA13_11725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RA13_11730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RA13_11735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RA13_11740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RA13_11745	COG0456	acetyltransferase
RA13_11750	COG1509	lysine 2,3-aminomutase activity
RA13_11780	COG0671	phosphoesterase, PA-phosphatase related
RA13_11795	COG0813	purine-nucleoside phosphorylase activity
RA13_11800	COG1876	peptidase activity
RA13_11810	COG2226	methyltransferase
RA13_11815	COG3409	Peptidoglycan-binding domain 1 protein
RA13_11815	COG0793	Belongs to the peptidase S41A family
RA13_11820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RA13_11830	COG0346	lactoylglutathione lyase activity
RA13_11835	COG0400	carboxylic ester hydrolase activity
RA13_11840	COG0778	Nitroreductase
RA13_11845	COG1733	regulation of RNA biosynthetic process
RA13_11850	COG1942	4-Oxalocrotonate Tautomerase
RA13_11870	COG2962	Rard protein
RA13_11880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RA13_11885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RA13_11890	COG1366	Belongs to the anti-sigma-factor antagonist family
RA13_11895	COG0582	viral genome integration into host DNA
RA13_11950	COG0305	Participates in initiation and elongation during chromosome replication
RA13_11975	COG1595	DNA-templated transcription, initiation
RA13_12020	COG1802	Transcriptional regulator
RA13_12020	COG4626	Terminase
RA13_12100	COG1705	Flagellar rod assembly protein muramidase FlgJ
RA13_12105	COG5434	Belongs to the glycosyl hydrolase 28 family
RA13_12125	COG4824	toxin secretion phage lysis holin
RA13_12130	COG3409	Peptidoglycan-binding domain 1 protein
RA13_12130	COG5632	N-Acetylmuramoyl-L-alanine amidase
RA13_12150	COG5444	nuclease activity
RA13_12175	COG0534	Mate efflux family protein
RA13_12180	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
RA13_12190	COG1388	LysM domain
RA13_12190	COG0791	NLP P60 protein
RA13_12195	COG2032	superoxide dismutase activity
RA13_12200	COG0714	Associated with various cellular activities
RA13_12205	COG4548	von Willebrand factor, type A
RA13_12210	COG0567	Dehydrogenase, E1 component
RA13_12215	COG0508	dehydrogenase complex catalyzes the overall conversion of
RA13_12220	COG0385	Bile acid
RA13_12225	COG0733	neurotransmitter:sodium symporter activity
RA13_12230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RA13_12235	COG1657	PFAM Prenyltransferase squalene oxidase
RA13_12240	COG1012	belongs to the aldehyde dehydrogenase family
RA13_12260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RA13_12265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RA13_12275	COG0514	ATP-dependent DNA helicase (RecQ)
RA13_12280	COG3584	3D domain protein
RA13_12280	COG1388	LysM domain
RA13_12285	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RA13_12295	COG2197	response regulator
RA13_12300	COG4585	Histidine kinase
RA13_12305	COG3239	Fatty acid desaturase
RA13_12320	COG2322	membrane
RA13_12325	COG0741	lytic transglycosylase activity
RA13_12330	COG0640	Transcriptional regulator
RA13_12345	COG3708	Transcriptional regulator
RA13_12350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RA13_12355	COG1309	transcriptional regulator
RA13_12360	COG2207	Transcriptional regulator
RA13_12360	COG0662	Cupin 2, conserved barrel domain protein
RA13_12365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RA13_12370	COG1309	transcriptional regulator
RA13_12385	COG0243	molybdopterin cofactor binding
RA13_12390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RA13_12395	COG1070	Carbohydrate kinase
RA13_12400	COG2814	Major facilitator Superfamily
RA13_12405	COG2318	DinB family
RA13_12410	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
RA13_12415	COG0300	oxidoreductase activity
RA13_12425	COG0693	protein deglycase activity
RA13_12460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RA13_12465	COG0583	DNA-binding transcription factor activity
RA13_12470	COG0070	glutamate synthase
RA13_12470	COG0069	glutamate synthase activity
RA13_12470	COG0067	glutamate synthase
RA13_12480	COG0604	alcohol dehydrogenase
RA13_12490	COG0405	Gamma-glutamyltransferase
RA13_12495	COG0166	Belongs to the GPI family
RA13_12500	COG0582	viral genome integration into host DNA
RA13_12515	COG4824	toxin secretion phage lysis holin
RA13_12530	COG0457	Tetratricopeptide repeat
RA13_12550	COG2017	converts alpha-aldose to the beta-anomer
RA13_12555	COG2027	D-alanyl-D-alanine carboxypeptidase
RA13_12560	COG1017	nitric oxide dioxygenase activity
RA13_12560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RA13_12565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA13_12570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA13_12575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA13_12585	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
RA13_12585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA13_12595	COG1649	PFAM Uncharacterised BCR, COG1649
RA13_12600	COG1960	acyl-CoA dehydrogenase activity
RA13_12605	COG0318	PFAM AMP-dependent synthetase and ligase
RA13_12610	COG0439	Biotin carboxylase
RA13_12615	COG0511	ligase activity, forming carbon-carbon bonds
RA13_12625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RA13_12630	COG2404	hydrolase activity, acting on ester bonds
RA13_12635	COG0586	Pfam SNARE associated Golgi protein
RA13_12640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RA13_12645	COG2246	polysaccharide biosynthetic process
RA13_12665	COG1115	amino acid carrier protein
RA13_12675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RA13_12680	COG0187	DNA topoisomerase II activity
RA13_12685	COG1832	CoA-binding protein
RA13_12690	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RA13_12695	COG4841	protein insertion into membrane
RA13_12705	COG0824	Thioesterase
RA13_12725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RA13_12730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RA13_12745	COG0071	Belongs to the small heat shock protein (HSP20) family
RA13_12755	COG4846	Membrane protein involved in cytochrome C biogenesis
RA13_12760	COG2201	protein-glutamate methylesterase activity
RA13_12765	COG0785	Cytochrome C biogenesis protein
RA13_12775	COG3763	UPF0154 protein
RA13_12785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RA13_12790	COG4224	UPF0291 protein
RA13_12795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RA13_12800	COG1388	LysM domain
RA13_12805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RA13_12815	COG5577	PFAM Coat F domain
RA13_12840	COG4195	phage-related replication protein
RA13_12860	COG3619	membrane
RA13_12915	COG1131	(ABC) transporter
RA13_12930	COG0457	Tetratricopeptide repeat
RA13_12945	COG2135	peptidase activity
RA13_12960	COG2030	dehydratase
RA13_12965	COG0789	Transcriptional regulator
RA13_12965	COG4978	Transcriptional regulator
RA13_12970	COG0456	acetyltransferase
RA13_12995	COG3409	Peptidoglycan-binding domain 1 protein
RA13_13005	COG5553	Cysteine dioxygenase type I
RA13_13020	COG0135	phosphoribosylanthranilate isomerase activity
RA13_13060	COG2367	Beta-lactamase
RA13_13095	COG1011	Hydrolase
RA13_13120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RA13_13125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RA13_13155	COG3118	belongs to the thioredoxin family
RA13_13165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RA13_13175	COG0509	glycine decarboxylation via glycine cleavage system
RA13_13185	COG1309	transcriptional regulator
RA13_13190	COG1609	Transcriptional regulator
RA13_13200	COG1175	transmembrane transport
RA13_13235	COG3391	amine dehydrogenase activity
RA13_13305	COG2273	Hydrolase Family 16
RA13_13350	COG5444	nuclease activity
RA13_13355	COG1136	(ABC) transporter
RA13_13385	COG4282	regulation of fungal-type cell wall biogenesis
RA13_13405	COG0456	acetyltransferase
RA13_13485	COG0174	glutamine synthetase
RA13_13490	COG0789	Transcriptional regulator
RA13_13495	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
RA13_13500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RA13_13515	COG3331	DNA recombination
RA13_13540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RA13_13595	COG4112	unkown
RA13_13610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RA13_13615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RA13_13635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RA13_13635	COG1372	Participates in initiation and elongation during chromosome replication
RA13_13640	COG1780	Probably involved in ribonucleotide reductase function
RA13_13745	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RA13_13765	COG3584	3D domain protein
RA13_13770	COG0587	DNA-directed DNA polymerase activity
RA13_13775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RA13_13780	COG0358	DNA primase activity
RA13_13785	COG0305	Participates in initiation and elongation during chromosome replication
RA13_13795	COG2887	Belongs to the helicase family. UvrD subfamily
RA13_13825	COG3420	alginic acid biosynthetic process
RA13_13825	COG5434	Belongs to the glycosyl hydrolase 28 family
RA13_13830	COG4195	phage-related replication protein
RA13_13865	COG1793	dna ligase
RA13_13910	COG1388	LysM domain
RA13_13980	COG3655	Transcriptional regulator
RA13_14075	COG3655	Transcriptional regulator
RA13_14165	COG0776	regulation of translation
RA13_14315	COG1196	nuclear chromosome segregation
RA13_14315	COG0741	lytic transglycosylase activity
RA13_14315	COG0739	heme binding
RA13_14325	COG2433	Pfam Transposase IS66
RA13_14335	COG5434	Belongs to the glycosyl hydrolase 28 family
RA13_14365	COG0457	Tetratricopeptide repeat
RA13_14375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RA13_14430	COG5444	nuclease activity
RA13_14435	COG4282	regulation of fungal-type cell wall biogenesis
RA13_14440	COG1525	nuclease
RA13_14460	COG0464	growth
RA13_14465	COG0860	N-Acetylmuramoyl-L-alanine amidase
RA13_14470	COG4112	unkown
RA13_14475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RA13_14480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RA13_14485	COG1780	Probably involved in ribonucleotide reductase function
RA13_14505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RA13_14525	COG2076	Multidrug Resistance protein
RA13_14535	COG1764	response to oxidative stress
RA13_14540	COG4195	phage-related replication protein
RA13_14550	COG1404	Belongs to the peptidase S8 family
RA13_14560	COG2124	cytochrome p450
RA13_14570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA13_14570	COG4221	oxidoreductase activity
RA13_14570	COG3321	synthase
RA13_14570	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_14575	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_14575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA13_14575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RA13_14575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RA13_14575	COG3321	synthase
RA13_14590	COG1024	Enoyl-CoA hydratase
RA13_14595	COG1024	Enoyl-CoA hydratase
RA13_14600	COG3425	synthase
RA13_14610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RA13_14620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RA13_14625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RA13_14630	COG3226	Transcriptional regulator
RA13_14645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RA13_14650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RA13_14660	COG4550	Control of competence regulator ComK, YlbF/YmcA
RA13_14675	COG0156	8-amino-7-oxononanoate synthase activity
RA13_14680	COG1063	alcohol dehydrogenase
RA13_14685	COG2359	stage V sporulation protein S
RA13_14690	COG1692	metallophosphoesterase
RA13_14700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RA13_14705	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RA13_14715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RA13_14720	COG1426	Protein conserved in bacteria
RA13_14740	COG0612	Peptidase, M16
RA13_14745	COG0612	Peptidase, M16
RA13_14755	COG2814	Major facilitator Superfamily
RA13_14760	COG2188	Transcriptional regulator
RA13_14765	COG4980	gas vesicle protein
RA13_14765	COG1674	ftsk spoiiie
RA13_14775	COG0740	serine-type endopeptidase activity
RA13_14780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RA13_14790	COG0527	aspartate kinase activity
RA13_14795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RA13_14800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RA13_14805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RA13_14810	COG1873	PFAM PRC-barrel domain
RA13_14815	COG0612	Peptidase, M16
RA13_14820	COG0726	polysaccharide deacetylase
RA13_14825	COG1185	polyribonucleotide nucleotidyltransferase activity
RA13_14835	COG0196	riboflavin kinase activity
RA13_14840	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RA13_14845	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RA13_14850	COG1550	Protein conserved in bacteria
RA13_14855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RA13_14860	COG1358	cellular component organization or biogenesis
RA13_14865	COG2740	Nucleic-acid-binding protein implicated in transcription termination
RA13_14870	COG0195	Participates in both transcription termination and antitermination
RA13_14875	COG0779	Required for maturation of 30S ribosomal subunits
RA13_14910	COG4589	Belongs to the CDS family
RA13_14920	COG0233	cytoplasmic translational termination
RA13_14925	COG0528	UMP kinase activity
RA13_14930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RA13_14945	COG1191	sigma factor activity
RA13_14950	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
RA13_14955	COG1776	CheC inhibitor of MCP methylation
RA13_14960	COG0835	chemotaxis
RA13_14965	COG2198	Histidine kinase
RA13_14965	COG0643	Histidine kinase
RA13_14970	COG2201	protein-glutamate methylesterase activity
RA13_14975	COG0455	bacterial-type flagellum organization
RA13_14980	COG1419	protein localization to endoplasmic reticulum
RA13_14985	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RA13_14990	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RA13_14995	COG1684	flagellar biosynthetic protein fliR
RA13_15000	COG1987	bacterial-type flagellum assembly
RA13_15005	COG1338	Plays a role in the flagellum-specific transport system
RA13_15010	COG3190	flagellar
RA13_15015	COG2201	protein-glutamate methylesterase activity
RA13_15020	COG1776	CheC inhibitor of MCP methylation
RA13_15020	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RA13_15025	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RA13_15030	COG1580	Controls the rotational direction of flagella during chemotaxis
RA13_15035	COG1582	Flagellar protein (FlbD)
RA13_15040	COG4786	Flagellar basal body rod
RA13_15045	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RA13_15050	COG3144	bacterial-type flagellum assembly
RA13_15055	COG3334	PFAM MgtE intracellular
RA13_15060	COG2882	bacterial-type flagellum organization
RA13_15065	COG1157	protein secretion by the type III secretion system
RA13_15070	COG1317	bacterial-type flagellum organization
RA13_15075	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RA13_15080	COG1766	The M ring may be actively involved in energy transduction
RA13_15085	COG1677	Flagellar hook-basal body complex protein FliE
RA13_15090	COG1558	bacterial-type flagellum-dependent cell motility
RA13_15095	COG1815	bacterial-type flagellum-dependent cell motility
RA13_15105	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RA13_15110	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RA13_15115	COG4974	Belongs to the 'phage' integrase family
RA13_15120	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RA13_15125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RA13_15130	COG0758	DNA mediated transformation
RA13_15135	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RA13_15145	COG2257	FlhB HrpN YscU SpaS Family
RA13_15155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RA13_15160	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RA13_15170	COG0336	Belongs to the RNA methyltransferase TrmD family
RA13_15175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RA13_15185	COG1837	Belongs to the UPF0109 family
RA13_15190	COG0228	four-way junction DNA binding
RA13_15200	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
RA13_15205	COG0552	protein localization to endoplasmic reticulum
RA13_15210	COG1196	nuclear chromosome segregation
RA13_15215	COG0571	ribonuclease III activity
RA13_15220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RA13_15225	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_15230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RA13_15240	COG1349	DNA-binding transcription factor activity
RA13_15240	COG2050	protein possibly involved in aromatic compounds catabolism
RA13_15245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RA13_15250	COG1760	l-serine dehydratase
RA13_15255	COG1760	l-serine dehydratase
RA13_15260	COG1461	Dihydroxyacetone kinase
RA13_15265	COG1302	Protein conserved in bacteria
RA13_15270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RA13_15280	COG1564	THIamine pyrophosphokinase
RA13_15285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RA13_15290	COG1162	GTPase activity
RA13_15295	COG2815	serine threonine protein kinase
RA13_15295	COG0515	serine threonine protein kinase
RA13_15300	COG0631	protein serine/threonine phosphatase activity
RA13_15310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RA13_15310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RA13_15315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RA13_15320	COG0242	peptide deformylase activity
RA13_15325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RA13_15330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RA13_15335	COG1758	RNA polymerase activity
RA13_15340	COG0194	GDP metabolic process
RA13_15345	COG2052	Domain of unknown function (DUF370)
RA13_15350	COG1561	YicC-like family, N-terminal region
RA13_15355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RA13_15375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RA13_15380	COG0529	Catalyzes the synthesis of activated sulfate
RA13_15385	COG2046	Belongs to the sulfate adenylyltransferase family
RA13_15390	COG0306	phosphate transporter
RA13_15395	COG0175	sulfate reduction
RA13_15400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RA13_15405	COG0284	orotidine-5'-phosphate decarboxylase activity
RA13_15410	COG0167	dihydroorotate dehydrogenase activity
RA13_15415	COG0543	2 iron, 2 sulfur cluster binding
RA13_15420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RA13_15425	COG0505	Belongs to the CarA family
RA13_15430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RA13_15435	COG0540	Belongs to the ATCase OTCase family
RA13_15440	COG2233	PERMEase
RA13_15450	COG0564	pseudouridine synthase activity
RA13_15460	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RA13_15465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RA13_15475	COG3599	regulation of cell shape
RA13_15480	COG2302	S4 RNA-binding domain
RA13_15485	COG0762	integral membrane protein
RA13_15490	COG1799	cell septum assembly
RA13_15495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RA13_15505	COG1873	PFAM PRC-barrel domain
RA13_15510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RA13_15515	COG1119	ATPase activity
RA13_15520	COG1191	sigma factor activity
RA13_15525	COG1191	sigma factor activity
RA13_15535	COG1404	Belongs to the peptidase S8 family
RA13_15535	COG4412	M6 family metalloprotease domain protein
RA13_15540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RA13_15550	COG3856	small basic protein
RA13_15560	COG3879	Bacterial protein of unknown function (DUF881)
RA13_15565	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RA13_15570	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RA13_15575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RA13_15580	COG0772	Belongs to the SEDS family
RA13_15585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RA13_15590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RA13_15595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RA13_15600	COG0768	penicillin binding
RA13_15610	COG4839	cell division protein FtsL
RA13_15615	COG0275	rRNA processing
RA13_15620	COG2001	Belongs to the MraZ family
RA13_15625	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
RA13_15645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RA13_15650	COG1399	metal-binding, possibly nucleic acid-binding protein
RA13_15660	COG1323	Belongs to the UPF0348 family
RA13_15665	COG3480	Lon protease (S16) C-terminal proteolytic domain
RA13_15670	COG1752	Esterase of the alpha-beta hydrolase superfamily
RA13_15675	COG3314	Sporulation integral membrane protein YlbJ
RA13_15680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RA13_15685	COG0742	ribosomal rna small subunit methyltransferase
RA13_15690	COG4471	UPF0298 protein
RA13_15695	COG3679	Belongs to the UPF0342 family
RA13_15715	COG2340	Cysteine-rich secretory protein family
RA13_15720	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
RA13_15730	COG3336	cytochrome c oxidase
RA13_15735	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RA13_15740	COG1845	cytochrome c oxidase, subunit III
RA13_15745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RA13_15750	COG2010	Cytochrome c
RA13_15750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RA13_15760	COG1612	heme a metabolic process
RA13_15765	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RA13_15770	COG0772	Belongs to the SEDS family
RA13_15775	COG4838	Belongs to the UPF0358 family
RA13_15785	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RA13_15790	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RA13_15800	COG4896	Protein conserved in bacteria
RA13_15835	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
RA13_15845	COG0483	inositol monophosphate 1-phosphatase activity
RA13_15855	COG4493	Belongs to the UPF0637 family
RA13_15860	COG4476	Belongs to the UPF0223 family
RA13_15865	COG1982	Orn Lys Arg decarboxylase major
RA13_15880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RA13_15885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RA13_15890	COG0508	dehydrogenase complex catalyzes the overall conversion of
RA13_15895	COG0022	dehydrogenase e1 component
RA13_15900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RA13_15905	COG0497	DNA recombination
RA13_15915	COG0242	peptide deformylase activity
RA13_15920	COG0561	phosphatase activity
RA13_15930	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RA13_15935	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RA13_15940	COG0569	domain protein
RA13_15945	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RA13_15945	COG2105	PFAM AIG2 family protein
RA13_15950	COG3852	Histidine kinase
RA13_15955	COG2002	toxin-antitoxin pair type II binding
RA13_15960	COG1077	Cell shape determining protein MreB Mrl
RA13_15970	COG2309	aminopeptidase activity
RA13_15975	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RA13_15980	COG0488	(ABC) transporter
RA13_15990	COG0681	Belongs to the peptidase S26 family
RA13_15995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RA13_15995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RA13_15995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RA13_16000	COG1105	Belongs to the carbohydrate kinase PfkB family
RA13_16005	COG1349	DNA-binding transcription factor activity
RA13_16010	COG0577	efflux transmembrane transporter activity
RA13_16020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RA13_16030	COG1132	(ABC) transporter
RA13_16035	COG1132	(ABC) transporter
RA13_16040	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RA13_16045	COG0314	molybdopterin synthase activity
RA13_16050	COG1763	Mo-molybdopterin cofactor biosynthetic process
RA13_16055	COG0303	'Molybdopterin
RA13_16060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RA13_16065	COG0746	molybdenum cofactor guanylyltransferase activity
RA13_16080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RA13_16085	COG0450	alkyl hydroperoxide reductase
RA13_16090	COG0668	transmembrane transport
RA13_16100	COG1473	amidohydrolase
RA13_16105	COG2171	N-acyltransferase activity
RA13_16110	COG0716	FMN binding
RA13_16120	COG0716	FMN binding
RA13_16125	COG0583	DNA-binding transcription factor activity
RA13_16130	COG0517	IMP dehydrogenase activity
RA13_16140	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
RA13_16145	COG4703	Protein of unknown function (DUF1797)
RA13_16150	COG3546	catalase activity
RA13_16155	COG2200	EAL domain
RA13_16160	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_16165	COG1408	metallophosphoesterase
RA13_16170	COG1376	ErfK ybiS ycfS ynhG family protein
RA13_16175	COG2814	Major facilitator Superfamily
RA13_16185	COG0835	chemotaxis
RA13_16185	COG0784	Response regulator, receiver
RA13_16195	COG0436	Aminotransferase
RA13_16200	COG4191	Histidine kinase
RA13_16205	COG0768	penicillin binding
RA13_16210	COG2340	Cysteine-rich secretory protein family
RA13_16215	COG2084	Dehydrogenase
RA13_16220	COG0840	transmembrane signaling receptor activity
RA13_16225	COG0456	acetyltransferase
RA13_16230	COG1533	DNA photolyase activity
RA13_16240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RA13_16245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RA13_16250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RA13_16250	COG1263	PTS System
RA13_16250	COG2190	(PTS) system
RA13_16255	COG3711	transcriptional antiterminator
RA13_16260	COG1609	Transcriptional regulator
RA13_16265	COG0006	proline dipeptidase activity
RA13_16275	COG2217	Heavy metal translocating P-type atpase
RA13_16280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RA13_16285	COG2244	polysaccharide biosynthetic process
RA13_16290	COG3773	Cell wall hydrolase
RA13_16300	COG4873	Protein conserved in bacteria
RA13_16315	COG1366	Belongs to the anti-sigma-factor antagonist family
RA13_16320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RA13_16325	COG0602	queuosine metabolic process
RA13_16330	COG0720	synthase
RA13_16345	COG3949	Membrane
RA13_16350	COG0542	response to heat
RA13_16355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RA13_16360	COG1360	Flagellar Motor Protein
RA13_16365	COG1846	Transcriptional regulator
RA13_16370	COG3852	Histidine kinase
RA13_16390	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
RA13_16395	COG0235	Class ii aldolase
RA13_16405	COG1850	ribulose-bisphosphate carboxylase activity
RA13_16410	COG0436	Aminotransferase
RA13_16415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RA13_16420	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
RA13_16430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RA13_16435	COG5002	protein histidine kinase activity
RA13_16440	COG3594	Acyltransferase
RA13_16455	COG2323	membrane
RA13_16460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RA13_16465	COG0501	Belongs to the peptidase M48B family
RA13_16485	COG1191	sigma factor activity
RA13_16490	COG0861	Integral membrane protein TerC family
RA13_16500	COG0586	Pfam SNARE associated Golgi protein
RA13_16520	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
RA13_16525	COG1793	dna ligase
RA13_16525	COG3285	dna ligase
RA13_16545	COG1408	metallophosphoesterase
RA13_16550	COG0726	polysaccharide deacetylase
RA13_16555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RA13_16560	COG1846	Transcriptional regulator
RA13_16575	COG0789	Transcriptional regulator
RA13_16580	COG2239	Acts as a magnesium transporter
RA13_16585	COG3212	peptidase
RA13_16625	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RA13_16630	COG1366	Belongs to the anti-sigma-factor antagonist family
RA13_16640	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RA13_16650	COG0590	tRNA wobble adenosine to inosine editing
RA13_16660	COG0463	Glycosyl transferase, family 2
RA13_16660	COG0457	Tetratricopeptide repeat
RA13_16680	COG1764	response to oxidative stress
RA13_16685	COG1846	Transcriptional regulator
RA13_16690	COG1764	response to oxidative stress
RA13_16695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RA13_16700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RA13_16705	COG0788	formyltetrahydrofolate deformylase activity
RA13_16710	COG2076	Multidrug Resistance protein
RA13_16715	COG2076	Multidrug Resistance protein
RA13_16720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RA13_16725	COG2318	DinB family
RA13_16740	COG1695	Transcriptional regulator
RA13_16745	COG2323	membrane
RA13_16750	COG1607	acyl-coa hydrolase
RA13_16755	COG1834	amidinotransferase
RA13_16760	COG2706	6-phosphogluconolactonase activity
RA13_16765	COG4608	Belongs to the ABC transporter superfamily
RA13_16770	COG0791	NLP P60 protein
RA13_16775	COG4948	Mandelate Racemase Muconate Lactonizing
RA13_16780	COG1619	proteins homologs of microcin C7 resistance protein MccF
RA13_16785	COG4166	transmembrane transport
RA13_16800	COG0601	transmembrane transport
RA13_16805	COG2362	D-Aminopeptidase
RA13_16810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RA13_16815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RA13_16825	COG0463	Glycosyl transferase, family 2
RA13_16830	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RA13_16835	COG0346	lactoylglutathione lyase activity
RA13_16840	COG0531	amino acid
RA13_16845	COG1392	Phosphate transport regulator
RA13_16850	COG0306	phosphate transporter
RA13_16865	COG5632	N-Acetylmuramoyl-L-alanine amidase
RA13_16865	COG3409	Peptidoglycan-binding domain 1 protein
RA13_16905	COG3778	Protein conserved in bacteria
RA13_16910	COG3299	homolog of phage Mu protein gp47
RA13_16915	COG3628	GPW Gp25 family protein
RA13_16930	COG4193	domain, Protein
RA13_16935	COG1652	LysM domain
RA13_16940	COG5412	phage tail tape measure protein
RA13_16940	COG3953	SLT domain
RA13_16990	COG4653	Phage capsid family
RA13_17000	COG5518	Phage portal protein
RA13_17005	COG1783	phage Terminase large subunit
RA13_17010	COG3728	DNA packaging
RA13_17010	COG5484	DNA packaging
RA13_17015	COG1595	DNA-templated transcription, initiation
RA13_17035	COG1484	DNA-dependent DNA replication
RA13_17040	COG1522	sequence-specific DNA binding
RA13_17050	COG1396	sequence-specific DNA binding
RA13_17055	COG2856	Zn peptidase
RA13_17060	COG4195	phage-related replication protein
RA13_17070	COG1388	LysM domain
RA13_17070	COG5632	N-Acetylmuramoyl-L-alanine amidase
RA13_17070	COG3409	Peptidoglycan-binding domain 1 protein
RA13_17080	COG0457	Tetratricopeptide repeat
RA13_17085	COG2318	DinB family
RA13_17090	COG0730	response to heat
RA13_17095	COG2721	sulfolactate sulfo-lyase activity
RA13_17100	COG0246	Mannitol dehydrogenase
RA13_17110	COG2211	Major facilitator Superfamily
RA13_17115	COG1904	glucuronate isomerase
RA13_17125	COG2318	DinB family
RA13_17130	COG1252	NADH dehydrogenase
RA13_17140	COG4297	protein containing double-stranded beta helix domain
RA13_17145	COG0697	spore germination
RA13_17150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RA13_17155	COG0390	transport system, permease component
RA13_17160	COG1587	Uroporphyrinogen-III synthase
RA13_17185	COG2124	cytochrome p450
RA13_17195	COG1051	belongs to the nudix hydrolase family
RA13_17205	COG2427	Protein of unknown function (DUF1641)
RA13_17210	COG3383	formate dehydrogenase (NAD+) activity
RA13_17220	COG2205	protein histidine kinase activity
RA13_17230	COG0726	polysaccharide deacetylase
RA13_17250	COG1285	pathogenesis
RA13_17255	COG3209	COG3209 Rhs family protein
RA13_17310	COG5444	nuclease activity
RA13_17325	COG5505	Protein of unknown function (DUF819)
RA13_17335	COG0626	cystathionine gamma-synthase activity
RA13_17340	COG0626	cystathionine gamma-synthase activity
RA13_17345	COG2382	esterase
RA13_17355	COG2153	protein acetylation
RA13_17380	COG0210	DNA helicase
RA13_17435	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RA13_17440	COG0351	phosphomethylpyrimidine kinase
RA13_17445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RA13_17450	COG2022	thiamine diphosphate biosynthetic process
RA13_17455	COG2104	thiamine diphosphate biosynthetic process
RA13_17460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RA13_17465	COG0352	thiamine-phosphate diphosphorylase activity
RA13_17470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RA13_17475	COG0569	domain protein
RA13_17475	COG0475	glutathione-regulated potassium exporter activity
RA13_17490	COG0564	pseudouridine synthase activity
RA13_17495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RA13_17500	COG2357	RelA SpoT domain protein
RA13_17510	COG4116	CYTH
RA13_17515	COG0741	lytic transglycosylase activity
RA13_17520	COG2346	COG2346, Truncated hemoglobins
RA13_17535	COG1164	Oligoendopeptidase f
RA13_17540	COG4469	Competence protein
RA13_17545	COG4862	establishment of competence for transformation
RA13_17550	COG0861	Integral membrane protein TerC family
RA13_17555	COG1393	Belongs to the ArsC family
RA13_17560	COG0456	acetyltransferase
RA13_17575	COG4608	Belongs to the ABC transporter superfamily
RA13_17580	COG0444	Belongs to the ABC transporter superfamily
RA13_17585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RA13_17590	COG0601	transmembrane transport
RA13_17595	COG4166	transmembrane transport
RA13_17605	COG0180	Tryptophanyl-tRNA synthetase
RA13_17615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RA13_17620	COG0601	transmembrane transport
RA13_17630	COG4608	Belongs to the ABC transporter superfamily
RA13_17635	COG0444	Belongs to the ABC transporter superfamily
RA13_17640	COG5504	Zn-dependent protease
RA13_17645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RA13_17650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RA13_17665	COG1744	ABC transporter substrate-binding protein PnrA-like
RA13_17675	COG2267	carboxylic ester hydrolase activity
RA13_17690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RA13_17695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RA13_17700	COG0505	Belongs to the CarA family
RA13_17705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RA13_17720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RA13_17725	COG2271	Major facilitator Superfamily
RA13_17730	COG0277	FAD linked oxidase domain protein
RA13_17740	COG2151	metal-sulfur cluster biosynthetic enzyme
RA13_17750	COG0561	phosphatase activity
RA13_17765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RA13_17770	COG1307	EDD domain protein, DegV family
RA13_17785	COG2996	Protein conserved in bacteria
RA13_17795	COG0646	methionine synthase
RA13_17795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RA13_17800	COG2153	protein acetylation
RA13_17805	COG0454	-acetyltransferase
RA13_17810	COG2814	Major facilitator Superfamily
RA13_17815	COG4948	Mandelate Racemase Muconate Lactonizing
RA13_17820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RA13_17825	COG1809	phosphosulfolactate synthase activity
RA13_17835	COG0175	sulfate reduction
RA13_17840	COG2046	Belongs to the sulfate adenylyltransferase family
RA13_17845	COG0529	Catalyzes the synthesis of activated sulfate
RA13_17860	COG1357	PFAM Pentapeptide repeats (8 copies)
RA13_17875	COG2318	DinB family
RA13_17880	COG0673	inositol 2-dehydrogenase activity
RA13_17885	COG1609	Transcriptional regulator
RA13_17890	COG0109	protoheme IX farnesyltransferase activity
RA13_17895	COG2207	Transcriptional regulator
RA13_17895	COG1917	Cupin 2, conserved barrel domain protein
RA13_17900	COG0534	Mate efflux family protein
RA13_17905	COG1562	ergosterol biosynthetic process
RA13_17910	COG0367	asparagine synthase
RA13_17930	COG0179	Fumarylacetoacetate (FAA) hydrolase
RA13_17935	COG5337	Spore coat protein CotH
RA13_17945	COG2311	Membrane
RA13_17980	COG1403	HNH endonuclease
RA13_17985	COG0419	ATPase involved in DNA repair
RA13_17990	COG0420	3'-5' exonuclease activity
RA13_17995	COG1074	ATP-dependent DNA helicase activity
RA13_18000	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
RA13_18005	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
RA13_18015	COG4533	DNA binding
RA13_18020	COG0477	Major facilitator Superfamily
RA13_18020	COG2814	Major facilitator Superfamily
RA13_18025	COG3180	Ammonia monooxygenase
RA13_18030	COG1846	Transcriptional regulator
RA13_18035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RA13_18040	COG0681	Belongs to the peptidase S26 family
RA13_18045	COG0398	Pfam SNARE associated Golgi protein
RA13_18060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RA13_18070	COG4903	ComK protein
RA13_18080	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_18085	COG0723	plastoquinol--plastocyanin reductase activity
RA13_18085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RA13_18090	COG0840	transmembrane signaling receptor activity
RA13_18100	COG1024	Enoyl-CoA hydratase
RA13_18105	COG1012	belongs to the aldehyde dehydrogenase family
RA13_18110	COG2084	Dehydrogenase
RA13_18115	COG1960	acyl-CoA dehydrogenase activity
RA13_18125	COG0183	Belongs to the thiolase family
RA13_18130	COG0406	alpha-ribazole phosphatase activity
RA13_18135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RA13_18140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RA13_18145	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RA13_18150	COG0604	alcohol dehydrogenase
RA13_18155	COG0456	acetyltransferase
RA13_18160	COG1404	Belongs to the peptidase S8 family
RA13_18165	COG0501	Belongs to the peptidase M48B family
RA13_18180	COG0702	epimerase
RA13_18185	COG0095	Lipoate-protein ligase
RA13_18190	COG1234	tRNA 3'-trailer cleavage
RA13_18200	COG1301	dicarboxylic acid transport
RA13_18205	COG1363	Peptidase, m42
RA13_18215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RA13_18220	COG1511	domain protein
RA13_18225	COG1309	transcriptional regulator
RA13_18240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RA13_18245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RA13_18250	COG2329	Antibiotic biosynthesis monooxygenase
RA13_18255	COG3069	C4-dicarboxylate transmembrane transporter activity
RA13_18260	COG1473	amidohydrolase
RA13_18270	COG4473	ABC transporter
RA13_18275	COG1131	(ABC) transporter
RA13_18280	COG0537	adenosine 5'-monophosphoramidase activity
RA13_18285	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RA13_18300	COG4980	gas vesicle protein
RA13_18340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RA13_18350	COG3481	metal-dependent phosphohydrolase, HD sub domain
RA13_18355	COG4717	serine-type aminopeptidase activity
RA13_18360	COG0420	3'-5' exonuclease activity
RA13_18365	COG1668	transmembrane transport
RA13_18370	COG4152	abc transporter atp-binding protein
RA13_18380	COG1024	Enoyl-CoA hydratase
RA13_18390	COG0490	domain, Protein
RA13_18395	COG0475	glutathione-regulated potassium exporter activity
RA13_18405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RA13_18410	COG0561	phosphatase activity
RA13_18425	COG4399	Belongs to the UPF0754 family
RA13_18435	COG0189	ligase activity
RA13_18440	COG0189	ligase activity
RA13_18460	COG0702	epimerase
RA13_18465	COG1132	(ABC) transporter
RA13_18470	COG1132	(ABC) transporter
RA13_18475	COG0589	response to stress
RA13_18480	COG1757	Na H antiporter
RA13_18485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RA13_18490	COG0726	polysaccharide deacetylase
RA13_18495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RA13_18500	COG0668	transmembrane transport
RA13_18510	COG0584	glycerophosphoryl diester phosphodiesterase
RA13_18515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RA13_18520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RA13_18525	COG1253	flavin adenine dinucleotide binding
RA13_18535	COG0789	Transcriptional regulator
RA13_18540	COG1253	flavin adenine dinucleotide binding
RA13_18545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RA13_18550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RA13_18555	COG0204	Acyl-transferase
RA13_18560	COG0667	Aldo Keto reductase
RA13_18565	COG1595	DNA-templated transcription, initiation
RA13_18580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RA13_18585	COG1012	belongs to the aldehyde dehydrogenase family
RA13_18590	COG4187	Peptidase family M20/M25/M40
RA13_18595	COG0833	amino acid
RA13_18600	COG0456	acetyltransferase
RA13_18620	COG0531	amino acid
RA13_18625	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_18630	COG0372	Belongs to the citrate synthase family
RA13_18635	COG0583	DNA-binding transcription factor activity
RA13_18640	COG0791	NLP P60 protein
RA13_18640	COG1388	LysM domain
RA13_18645	COG1785	Belongs to the alkaline phosphatase family
RA13_18650	COG2719	SpoVR family
RA13_18655	COG0668	transmembrane transport
RA13_18660	COG1959	2 iron, 2 sulfur cluster binding
RA13_18665	COG1388	LysM domain
RA13_18665	COG0791	NLP P60 protein
RA13_18680	COG0431	NADPH-dependent FMN reductase
RA13_18685	COG2197	response regulator
RA13_18690	COG2203	Gaf domain
RA13_18690	COG4585	Histidine kinase
RA13_18695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RA13_18700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RA13_18705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RA13_18710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RA13_18715	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RA13_18720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RA13_18730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RA13_18730	COG3153	acetyltransferase
RA13_18735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RA13_18740	COG0517	IMP dehydrogenase activity
RA13_18750	COG0564	pseudouridine synthase activity
RA13_18755	COG3764	Sortase (surface protein transpeptidase)
RA13_18770	COG5577	PFAM Coat F domain
RA13_18790	COG1823	symporter activity
RA13_18795	COG3706	GGDEF domain
RA13_18800	COG1464	Belongs to the NlpA lipoprotein family
RA13_18810	COG1278	Cold shock
RA13_18815	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
RA13_18820	COG1131	(ABC) transporter
RA13_18825	COG1131	(ABC) transporter
RA13_18830	COG1725	Transcriptional regulator
RA13_18845	COG0655	NAD(P)H dehydrogenase (quinone) activity
RA13_18850	COG2814	Major facilitator Superfamily
RA13_18855	COG1566	PFAM secretion protein HlyD family protein
RA13_18860	COG1846	Transcriptional regulator
RA13_18865	COG2718	Belongs to the UPF0229 family
RA13_18870	COG2766	serine protein kinase
RA13_18875	COG1664	Polymer-forming cytoskeletal
RA13_18880	COG1664	Polymer-forming cytoskeletal
RA13_18885	COG0789	Transcriptional regulator
RA13_18890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RA13_18900	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RA13_18905	COG3382	B3 4 domain protein
RA13_18915	COG1476	TRANSCRIPTIONal
RA13_18925	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RA13_18935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RA13_18940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RA13_18950	COG0753	catalase activity
RA13_18960	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RA13_18970	COG4326	sporulation control protein
RA13_19095	COG0735	belongs to the Fur family
RA13_19100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RA13_19105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RA13_19110	COG4129	membrane
RA13_19115	COG1132	(ABC) transporter
RA13_19120	COG3557	Belongs to the UPF0374 family
RA13_19135	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_19145	COG1194	a g-specific adenine glycosylase
RA13_19150	COG1988	membrane-bound metal-dependent
RA13_19155	COG4485	Bacterial membrane protein, YfhO
RA13_19160	COG0463	Glycosyl transferase, family 2
RA13_19165	COG0596	Alpha beta hydrolase
RA13_19170	COG5658	integral membrane protein
RA13_19175	COG3103	Sh3 type 3 domain protein
RA13_19190	COG2814	Major facilitator Superfamily
RA13_19200	COG2137	regulation of response to DNA damage stimulus
RA13_19205	COG1090	epimerase
RA13_19220	COG0778	Nitroreductase
RA13_19225	COG0384	phenazine biosynthesis protein PhzF
RA13_19230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RA13_19235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RA13_19240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RA13_19250	COG1846	Transcriptional regulator
RA13_19255	COG2814	Major facilitator Superfamily
RA13_19260	COG2318	DinB family
RA13_19265	COG0604	alcohol dehydrogenase
RA13_19270	COG2732	(Barnase) inhibitor
RA13_19275	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
RA13_19280	COG1695	Transcriptional regulator
RA13_19285	COG0842	Transport permease protein
RA13_19295	COG2514	catechol 2,3-dioxygenase activity
RA13_19300	COG2259	Doxx family
RA13_19305	COG1132	(ABC) transporter
RA13_19310	COG1132	(ABC) transporter
RA13_19315	COG5434	Belongs to the glycosyl hydrolase 28 family
RA13_19320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RA13_19320	COG1263	PTS System
RA13_19325	COG1737	Transcriptional regulator
RA13_19330	COG1486	melibiose metabolic process
RA13_19335	COG4842	Belongs to the WXG100 family
RA13_19355	COG1742	UPF0060 membrane protein
RA13_19365	COG3284	Transcriptional regulator
RA13_19370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RA13_19375	COG0508	dehydrogenase complex catalyzes the overall conversion of
RA13_19385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RA13_19390	COG4637	Psort location Cytoplasmic, score
RA13_19395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RA13_19400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RA13_19410	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
RA13_19415	COG0598	Magnesium transport protein CorA
RA13_19425	COG2084	Dehydrogenase
RA13_19430	COG0726	polysaccharide deacetylase
RA13_19440	COG0535	radical SAM domain protein
RA13_19445	COG0668	transmembrane transport
RA13_19455	COG0387	Pfam Sodium calcium exchanger
RA13_19460	COG0477	Major facilitator Superfamily
RA13_19465	COG1295	ribonuclease BN
RA13_19470	COG4980	gas vesicle protein
RA13_19475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RA13_19480	COG4840	Belongs to the UPF0435 family
RA13_19485	COG2814	Major facilitator Superfamily
RA13_19495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RA13_19500	COG2814	Major facilitator Superfamily
RA13_19505	COG1609	Transcriptional regulator
RA13_19510	COG0693	protein deglycase activity
RA13_19515	COG0737	Belongs to the 5'-nucleotidase family
RA13_19520	COG0778	Nitroreductase
RA13_19525	COG2188	Transcriptional regulator
RA13_19530	COG0366	Alpha amylase catalytic
RA13_19535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RA13_19535	COG1263	PTS System
RA13_19550	COG1368	sulfuric ester hydrolase activity
RA13_19555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RA13_19555	COG1263	PTS System
RA13_19580	COG2258	MOSC domain
RA13_19585	COG1254	Belongs to the acylphosphatase family
RA13_19590	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
RA13_19595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RA13_19600	COG2851	Citrate transporter
RA13_19605	COG3181	Tripartite tricarboxylate transporter family receptor
RA13_19610	COG4565	transcriptional regulatory protein
RA13_19620	COG0471	metal ion transport
RA13_19630	COG3866	Pectate lyase
RA13_19645	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RA13_19650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RA13_19655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RA13_19660	COG1120	ATPase activity
RA13_19665	COG2130	NADP-dependent
RA13_19670	COG0513	Belongs to the DEAD box helicase family
RA13_19675	COG0488	(ABC) transporter
RA13_19680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RA13_19685	COG2814	Major facilitator Superfamily
RA13_19690	COG0789	Transcriptional regulator
RA13_19695	COG0488	(ABC) transporter
RA13_19700	COG0463	Glycosyl transferase, family 2
RA13_19705	COG0840	transmembrane signaling receptor activity
RA13_19710	COG1012	belongs to the aldehyde dehydrogenase family
RA13_19715	COG0531	amino acid
RA13_19720	COG2223	nitrite transmembrane transporter activity
RA13_19725	COG1442	glycosyl transferase family 8
RA13_19730	COG1216	Glycosyl transferase, family 2
RA13_19735	COG1442	glycosyl transferase family 8
RA13_19740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RA13_19745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RA13_19750	COG1368	sulfuric ester hydrolase activity
RA13_19760	COG1131	(ABC) transporter
RA13_19775	COG2124	cytochrome p450
RA13_19775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RA13_19785	COG0670	Belongs to the BI1 family
RA13_19790	COG0196	riboflavin kinase activity
RA13_19795	COG5583	Uncharacterized small protein (DUF2292)
RA13_19800	COG1366	Belongs to the anti-sigma-factor antagonist family
RA13_19805	COG0346	lactoylglutathione lyase activity
RA13_19810	COG2329	Antibiotic biosynthesis monooxygenase
RA13_19815	COG2323	membrane
RA13_19820	COG1486	melibiose metabolic process
RA13_19825	COG0395	ABC-type sugar transport system, permease component
RA13_19830	COG4209	transmembrane transport
RA13_19835	COG1653	transport
RA13_19845	COG1874	Beta-galactosidase
RA13_19850	COG2755	lipolytic protein G-D-S-L family
RA13_19855	COG0667	Aldo Keto reductase
RA13_19860	COG3401	FG-GAP repeat protein
RA13_19865	COG3401	FG-GAP repeat protein
RA13_19870	COG5578	integral membrane protein
RA13_19880	COG2755	lipolytic protein G-D-S-L family
RA13_19885	COG2207	Transcriptional regulator
RA13_19890	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
RA13_19900	COG1175	transmembrane transport
RA13_19905	COG1653	transport
RA13_19910	COG4753	response regulator
RA13_19910	COG2207	Transcriptional regulator
RA13_19920	COG5578	integral membrane protein
RA13_19930	COG0454	-acetyltransferase
RA13_19935	COG3546	catalase activity
RA13_19960	COG0457	Tetratricopeptide repeat
RA13_19970	COG5444	nuclease activity
RA13_19985	COG0457	Tetratricopeptide repeat
RA13_20020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RA13_20025	COG1597	lipid kinase activity
RA13_20030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RA13_20035	COG1309	transcriptional regulator
RA13_20045	COG0154	amidase activity
RA13_20055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RA13_20060	COG1285	pathogenesis
RA13_20065	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RA13_20075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RA13_20080	COG0210	DNA helicase
RA13_20085	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
RA13_20090	COG0069	glutamate synthase activity
RA13_20095	COG4496	protein, YerC YecD
RA13_20100	COG1470	cell adhesion involved in biofilm formation
RA13_20105	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RA13_20115	COG0531	amino acid
RA13_20120	COG1522	sequence-specific DNA binding
RA13_20125	COG0151	Belongs to the GarS family
RA13_20130	COG0138	bifunctional purine biosynthesis protein purh
RA13_20135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RA13_20145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RA13_20150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RA13_20155	COG0047	phosphoribosylformylglycinamidine synthase activity
RA13_20160	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RA13_20165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RA13_20170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RA13_20175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RA13_20180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RA13_20190	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
RA13_20200	COG3064	Membrane
RA13_20205	COG2252	PERMEase
RA13_20225	COG1305	Transglutaminase-like
RA13_20230	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
RA13_20235	COG0714	Associated with various cellular activities
RA13_20240	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RA13_20250	COG1113	amino acid transport
RA13_20255	COG2132	Multicopper oxidase
RA13_20265	COG2267	carboxylic ester hydrolase activity
RA13_20280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RA13_20285	COG1063	alcohol dehydrogenase
RA13_20290	COG2814	Major facilitator Superfamily
RA13_20295	COG1846	Transcriptional regulator
RA13_20300	COG0778	Nitroreductase
RA13_20310	COG1595	DNA-templated transcription, initiation
RA13_20320	COG4260	virion core protein, lumpy skin disease virus
RA13_20325	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RA13_20330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RA13_20335	COG1842	Phage shock protein A
RA13_20340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RA13_20350	COG1063	alcohol dehydrogenase
RA13_20355	COG0457	Tetratricopeptide repeat
RA13_20395	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RA13_20400	COG1266	CAAX protease self-immunity
RA13_20410	COG0805	protein transport
RA13_20415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RA13_20425	COG0315	cyclic pyranopterin monophosphate synthase activity
RA13_20430	COG0488	(ABC) transporter
RA13_20435	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RA13_20440	COG0456	acetyltransferase
RA13_20445	COG1214	PFAM Peptidase M22, glycoprotease
RA13_20450	COG0802	atpase or kinase
RA13_20455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RA13_20500	COG1378	Sugar-specific transcriptional regulator TrmB
RA13_20515	COG2807	transmembrane transport
RA13_20520	COG2186	Transcriptional regulator
RA13_20525	COG2814	Major facilitator Superfamily
RA13_20540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RA13_20545	COG5434	Belongs to the glycosyl hydrolase 28 family
RA13_20550	COG1174	glycine betaine transport
RA13_20555	COG0517	IMP dehydrogenase activity
RA13_20555	COG1125	glycine betaine transport
RA13_20570	COG1785	Belongs to the alkaline phosphatase family
RA13_20585	COG1819	glycosyl
RA13_20590	COG1388	LysM domain
RA13_20590	COG3858	chitin binding
RA13_20600	COG2814	Major facilitator Superfamily
RA13_20610	COG2602	Beta-lactamase
RA13_20625	COG0596	Alpha beta hydrolase
RA13_20635	COG1522	sequence-specific DNA binding
RA13_20640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RA13_20660	COG1482	cell wall glycoprotein biosynthetic process
RA13_20665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RA13_20665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RA13_20665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RA13_20670	COG3711	transcriptional antiterminator
RA13_20670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RA13_20675	COG1033	growth of symbiont in host cell
RA13_20675	COG2409	Drug exporters of the RND superfamily
RA13_20680	COG1846	Transcriptional regulator
RA13_20690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RA13_20700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RA13_20705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RA13_20710	COG0640	Transcriptional regulator
RA13_20715	COG0640	Transcriptional regulator
RA13_20720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RA13_20725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RA13_20730	COG0697	spore germination
RA13_20745	COG2814	Major facilitator Superfamily
RA13_20765	COG0697	spore germination
RA13_20770	COG0456	acetyltransferase
RA13_20775	COG1846	Transcriptional regulator
RA13_20780	COG2364	Membrane
RA13_20785	COG2315	Protein conserved in bacteria
RA13_20790	COG1329	Transcriptional regulator
RA13_20795	COG1278	Cold shock
RA13_20805	COG3239	Fatty acid desaturase
RA13_20810	COG2814	Major facilitator Superfamily
RA13_20815	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RA13_20830	COG1522	sequence-specific DNA binding
RA13_20845	COG0745	RESPONSE REGULATOR receiver
RA13_20850	COG5002	protein histidine kinase activity
RA13_20860	COG0726	polysaccharide deacetylase
RA13_20895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RA13_20900	COG0251	oxidation-reduction process
RA13_20970	COG3091	SprT-like family
RA13_20980	COG2183	response to ionizing radiation
RA13_20985	COG2208	phosphoserine phosphatase activity
RA13_20990	COG1191	sigma factor activity
RA13_20995	COG2172	sigma factor antagonist activity
RA13_21000	COG1366	Belongs to the anti-sigma-factor antagonist family
RA13_21005	COG2208	phosphoserine phosphatase activity
RA13_21010	COG2172	sigma factor antagonist activity
RA13_21015	COG1366	Belongs to the anti-sigma-factor antagonist family
RA13_21020	COG1366	Belongs to the anti-sigma-factor antagonist family
RA13_21025	COG2337	Toxic component of a toxin-antitoxin (TA) module
RA13_21030	COG0864	Transcriptional regulator
RA13_21035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RA13_21040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RA13_21045	COG0736	holo-[acyl-carrier-protein] synthase activity
RA13_21050	COG0705	Rhomboid family
RA13_21055	COG3428	Bacterial PH domain
RA13_21060	COG3402	PFAM membrane-flanked domain
RA13_21065	COG0513	Belongs to the DEAD box helicase family
RA13_21075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RA13_21080	COG1181	Belongs to the D-alanine--D-alanine ligase family
RA13_21085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RA13_21090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RA13_21105	COG1960	acyl-CoA dehydrogenase activity
RA13_21115	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
RA13_21120	COG1131	(ABC) transporter
RA13_21125	COG0628	permease
RA13_21130	COG1301	dicarboxylic acid transport
RA13_21135	COG4565	transcriptional regulatory protein
RA13_21140	COG3290	protein histidine kinase activity
RA13_21145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RA13_21150	COG3546	catalase activity
RA13_21160	COG0662	Cupin 2, conserved barrel domain protein
RA13_21165	COG3729	General stress protein
RA13_21170	COG2217	Heavy metal translocating P-type atpase
RA13_21175	COG4876	unkown
RA13_21180	COG2261	transglycosylase associated protein
RA13_21185	COG1914	H( )-stimulated, divalent metal cation uptake system
RA13_21215	COG0028	Belongs to the TPP enzyme family
RA13_21225	COG0531	amino acid
RA13_21240	COG3706	GGDEF domain
RA13_21245	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
RA13_21255	COG1522	sequence-specific DNA binding
RA13_21270	COG2814	Major facilitator Superfamily
RA13_21285	COG3871	stress protein (general stress protein 26)
RA13_21290	COG1917	Cupin 2, conserved barrel domain protein
RA13_21295	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_21305	COG0318	PFAM AMP-dependent synthetase and ligase
RA13_21310	COG3711	transcriptional antiterminator
RA13_21315	COG4989	oxidoreductase activity
RA13_21320	COG0768	penicillin binding
RA13_21325	COG2329	Antibiotic biosynthesis monooxygenase
RA13_21340	COG1414	Transcriptional regulator
RA13_21345	COG1984	allophanate hydrolase subunit 2
RA13_21350	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RA13_21355	COG4336	lyase activity
RA13_21360	COG1914	H( )-stimulated, divalent metal cation uptake system
RA13_21365	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RA13_21370	COG0561	phosphatase activity
RA13_21385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RA13_21390	COG0412	Dienelactone hydrolase
RA13_21395	COG0246	Mannitol dehydrogenase
RA13_21400	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RA13_21405	COG2213	PTS system mannitol-specific
RA13_21415	COG1349	DNA-binding transcription factor activity
RA13_21420	COG2372	response to copper ion
RA13_21420	COG1276	copper resistance
RA13_21425	COG4549	nuclear export factor GLE1
RA13_21430	COG1028	Short-chain dehydrogenase reductase Sdr
RA13_21435	COG4975	Glucose uptake
RA13_21440	COG1012	belongs to the aldehyde dehydrogenase family
RA13_21445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RA13_21455	COG0640	Transcriptional regulator
RA13_21460	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
RA13_21465	COG0778	Nitroreductase
RA13_21470	COG0457	Tetratricopeptide repeat
RA13_21475	COG1309	transcriptional regulator
RA13_21480	COG2814	Major facilitator Superfamily
RA13_21485	COG4607	ABC-type enterochelin transport system periplasmic component
RA13_21490	COG4604	ABC transporter, ATP-binding protein
RA13_21495	COG4605	iron ion homeostasis
RA13_21500	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RA13_21505	COG0527	aspartate kinase activity
RA13_21525	COG0457	Tetratricopeptide repeat
RA13_21530	COG3850	Histidine kinase
RA13_21530	COG5002	protein histidine kinase activity
RA13_21540	COG0577	efflux transmembrane transporter activity
RA13_21545	COG1136	(ABC) transporter
RA13_21550	COG2079	MmgE PrpD family protein
RA13_21560	COG1126	abc transporter atp-binding protein
RA13_21565	COG0765	amino acid transport
RA13_21570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RA13_21585	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
RA13_21605	COG5434	Belongs to the glycosyl hydrolase 28 family
RA13_21610	COG3104	oligopeptide transport
RA13_21615	COG0596	Alpha beta hydrolase
RA13_21630	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RA13_21635	COG0163	prenyltransferase activity
RA13_21640	COG0583	DNA-binding transcription factor activity
RA13_21645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RA13_21655	COG1126	abc transporter atp-binding protein
RA13_21660	COG2364	Membrane
RA13_21670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RA13_21675	COG0697	spore germination
RA13_21685	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
RA13_21690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA13_21695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA13_21700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RA13_21705	COG1733	regulation of RNA biosynthetic process
RA13_21710	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
RA13_21715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RA13_21720	COG0840	transmembrane signaling receptor activity
RA13_21720	COG3290	protein histidine kinase activity
RA13_21725	COG3209	COG3209 Rhs family protein
RA13_21735	COG2723	6-phospho-beta-galactosidase activity
RA13_21755	COG1714	RDD family
RA13_21765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RA13_21770	COG0765	amino acid transport
RA13_21775	COG0523	cobalamin synthesis protein
RA13_21780	COG1376	ErfK ybiS ycfS ynhG family protein
RA13_21785	COG1469	GTP cyclohydrolase I activity
RA13_21790	COG2223	nitrite transmembrane transporter activity
RA13_21795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RA13_21800	COG0243	molybdopterin cofactor binding
RA13_21805	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RA13_21810	COG2146	nitrite reductase [NAD(P)H] activity
RA13_21815	COG1587	Uroporphyrinogen-III synthase
RA13_21815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RA13_21830	COG0701	Predicted permease
RA13_21835	COG3689	TIGRFAM TIGR03943 family protein
RA13_21840	COG2508	Transcriptional regulator
RA13_21845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RA13_21850	COG1012	belongs to the aldehyde dehydrogenase family
RA13_21860	COG3541	Predicted nucleotidyltransferase
RA13_21865	COG3458	cephalosporin-C deacetylase activity
RA13_21875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RA13_21880	COG1082	Xylose isomerase domain protein TIM barrel
RA13_21885	COG1660	Displays ATPase and GTPase activities
RA13_21895	COG3665	Urea carboxylase-associated protein
RA13_21900	COG1113	amino acid transport
RA13_21905	COG3403	YqcI/YcgG family
RA13_21910	COG1280	lysine exporter protein (LysE YggA)
RA13_21915	COG1846	Transcriptional regulator
RA13_21920	COG2814	Major facilitator Superfamily
RA13_21925	COG1620	l-lactate permease
RA13_21930	COG0039	L-malate dehydrogenase activity