locus-tag class description TD68_00015 ENOG4105G6Z alkaline phosphatase TD68_00025 ENOG4105FQP Beta-lactamase TD68_00030 ENOG4108IJ8 ABC transporter TD68_00035 ENOG4105E90 ABC transporter TD68_00060 ENOG4105F27 Major Facilitator TD68_00065 ENOG4105JXH GntR family transcriptional regulator TD68_00070 ENOG4105DJ2 Major Facilitator Superfamily TD68_00085 ENOG4108NGU Transcriptional regulator TD68_00130 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) TD68_00135 ENOG4105K8N protein family UPF0079, ATPase TD68_00140 ENOG41072GX Peptidase M22 Glycoprotease TD68_00145 ENOG410801F ribosomal-protein-alanine acetyltransferase TD68_00150 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) TD68_00155 ENOG4105C5H ABC transporter TD68_00160 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) TD68_00165 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) TD68_00170 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) TD68_00175 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) TD68_00185 ENOG4108TYN CAAX amino terminal protease family protein TD68_00190 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) TD68_00195 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) TD68_00210 ENOG4105ED2 Beta-lactamase TD68_00215 ENOG4105WH1 Two component transcriptional regulator luxr family TD68_00220 ENOG4105PGZ NB-ARC domain TD68_00225 ENOG4105CPQ Dehydrogenase TD68_00230 ENOG4105CT4 transporter TD68_00240 ENOG41087YS Phage shock protein A TD68_00245 ENOG4105DQX Zinc finger domain TD68_00250 ENOG4108WV1 Pfam:DUF477 TD68_00260 ENOG4108P49 AntiSigma factor TD68_00265 ENOG4105JVQ RNA Polymerase TD68_00275 ENOG4108TVJ Nitroreductase TD68_00280 ENOG4105FS7 Transcriptional regulator TD68_00285 ENOG4107QNK )-transporter TD68_00310 ENOG4107YUH hydrolase TD68_00320 ENOG4107STQ Multicopper oxidase TD68_00325 ENOG4105C85 amino acid TD68_00340 ENOG4105C7R Atpase associated with various cellular activities aaa_3 TD68_00370 ENOG4105C7N Xanthine uracil vitamin C permease TD68_00390 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) TD68_00395 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit TD68_00400 ENOG4105C83 adenylosuccinate lyase TD68_00405 ENOG4105C8V SAICAR synthetase TD68_00410 ENOG4105VR9 phosphoribosylformylglycinamidine synthase TD68_00415 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I TD68_00420 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii TD68_00430 ENOG4105CXB phosphoribosylaminoimidazole synthetase TD68_00435 ENOG4108V3E phosphoribosylglycinamide formyltransferase TD68_00440 ENOG4105DC1 bifunctional purine biosynthesis protein purh TD68_00445 ENOG4105C12 Phosphoribosylglycinamide synthetase TD68_00455 ENOG4105DVH amino acid TD68_00470 ENOG4108R5T secreted protein TD68_00475 ENOG4105KGF protein, YerC YecD TD68_00480 ENOG4105CBC glutamate synthase TD68_00485 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) TD68_00490 ENOG4105C4R Atp-dependent dna helicase TD68_00495 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) TD68_00505 ENOG4105CRN Aminoglycoside phosphotransferase TD68_00510 ENOG4105KT7 mgtC SapB transporter TD68_00515 ENOG4105CK7 Sodium proline symporter TD68_00520 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) TD68_00525 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) TD68_00530 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) TD68_00535 ENOG4108IG5 Transcriptional regulator TD68_00545 ENOG4105CBD Diacylglycerol kinase TD68_00550 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) TD68_00555 ENOG4105WH1 Two component transcriptional regulator luxr family TD68_00575 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) TD68_00585 ENOG4105CHR reductase TD68_00590 ENOG4105CJ1 ABC, transporter TD68_00615 ENOG410780I phosphoprotein phosphatase activity TD68_00650 ENOG4105CDY transcriptional regulatory protein TD68_00665 ENOG4105WEF catalase TD68_00670 ENOG4105M18 -acetyltransferase TD68_00685 ENOG4105C2F Histidine kinase TD68_00690 ENOG4105EQD regulatoR TD68_00695 ENOG410769Z extracellular solute-binding protein family 1 TD68_00700 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component TD68_00705 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component TD68_00710 ENOG4105F5H Glycosyl Hydrolase Family 88 TD68_00715 ENOG41075H3 AraC family transcriptional regulator TD68_00720 ENOG4107TDE lipolytic protein G-D-S-L family TD68_00735 ENOG4105CX8 fg-gap repeat protein TD68_00740 ENOG4105CX8 fg-gap repeat protein TD68_00745 ENOG4107TDE lipolytic protein G-D-S-L family TD68_00755 ENOG4105EKC TD68_00760 ENOG4105E0S extracellular solute-binding protein family 1 TD68_00770 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component TD68_00775 ENOG4105F8D glycoside hydrolase family 4 TD68_00780 ENOG4105H67 Protein of unknown function (DUF421) TD68_00785 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) TD68_00790 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TD68_00805 ENOG4106I4J membrane TD68_00810 ENOG4108R1P TD68_00815 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) TD68_00830 ENOG4105CJ1 ABC, transporter TD68_00840 ENOG4105E0M Sulfatase TD68_00845 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase TD68_00855 ENOG41090R9 glycosyltransferase TD68_00860 ENOG4107R51 Glycosyl transferase, family 2 TD68_00865 ENOG41090R9 glycosyltransferase TD68_00870 ENOG4105EU0 Major facilitator Superfamily TD68_00875 ENOG4105CUB amino acid TD68_00880 ENOG4105C26 Dehydrogenase TD68_00885 ENOG4105FKZ Methyl-accepting chemotaxis TD68_00890 ENOG4106WTF Glycosyl transferase, family 2 TD68_00895 ENOG4105C5H ABC transporter TD68_00900 ENOG4107SWG transcriptional regulator MERR family TD68_00905 ENOG4105DXB Major Facilitator superfamily TD68_00915 ENOG4105C5H ABC transporter TD68_00920 ENOG4105FDU atp-dependent rna helicase TD68_00930 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein TD68_00935 ENOG4105E0A ABC, transporter TD68_00940 ENOG4108U1V ABC transporter, permease TD68_00945 ENOG4105DQ5 transport system permease protein TD68_00950 ENOG4108HUF Transporter TD68_00965 ENOG4108J20 pectate lyase TD68_00975 ENOG4107QPK )-transporter TD68_01000 ENOG4108MRH transcriptional regulatory protein TD68_01025 ENOG410855V Acylphosphatase TD68_01030 ENOG4108RPX mosc domain containing protein TD68_01040 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) TD68_01065 ENOG4105C5Y PTS System TD68_01070 ENOG4105CG3 alpha amylase, catalytic region TD68_01075 ENOG4107414 GntR family transcriptional regulator TD68_01080 ENOG4108RCM Nitroreductase TD68_01085 ENOG4105CGH 5'-nucleotidase TD68_01090 ENOG4107RKG DJ-1/PfpI family TD68_01095 ENOG4105ETE Transcriptional regulator (LacI family TD68_01105 ENOG4105E2X shikimate dehydrogenase TD68_01110 ENOG4105FF2 Type I DHQase TD68_01125 ENOG4105KJF protein tyrosine phosphatase TD68_01135 ENOG4107U9T Pfam:Ribonuclease_BN TD68_01140 ENOG4108ISG Major Facilitator TD68_01145 ENOG4105UPD Calcium Proton TD68_01155 ENOG4105D8X mechanosensitive ion channel TD68_01175 ENOG4106KE4 Dehydrogenase TD68_01185 ENOG4105D7N magnesium and cobalt transport protein CorA TD68_01200 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) TD68_01215 ENOG4107RUY (E1 component), alpha subunit TD68_01225 ENOG4107QKR Dehydrogenase TD68_01235 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family TD68_01240 ENOG41069DP small acid-soluble spore protein TD68_01245 ENOG4105KK4 UPF0060 membrane protein TD68_01270 ENOG4105F8D glycoside hydrolase family 4 TD68_01275 ENOG4108Q3X Transcriptional regulator TD68_01280 ENOG4105CI1 PTS System TD68_01290 ENOG4105BZ1 (ABC) transporter TD68_01295 ENOG4105BZ1 (ABC) transporter TD68_01305 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase TD68_01310 ENOG4108KYE ABC-2 type transporter TD68_01315 ENOG4105U3E Transcriptional regulator TD68_01320 ENOG4105H93 Acyltransferase family TD68_01330 ENOG4105CIS alcohol dehydrogenase TD68_01335 ENOG4108YYS metal-dependent hydrolase (By similarity) TD68_01340 ENOG4105C0R drug resistance transporter emrb qaca subfamily TD68_01345 ENOG410834F Transcriptional regulator TD68_01355 ENOG4108MES Periplasmic binding protein TD68_01360 ENOG4105DQ5 transport system permease protein TD68_01365 ENOG4108IHU transport system permease protein TD68_01370 ENOG4105JAB phenazine biosynthesis protein, phzf family TD68_01375 ENOG4107Y03 Nitroreductase TD68_01385 ENOG4105ECP epimerase TD68_01400 ENOG4105F27 Major Facilitator TD68_01420 ENOG4106AKJ TD68_01425 ENOG4105D74 hydrolase TD68_01430 ENOG4105CKK Glycosyl transferase, family 2 TD68_01435 ENOG4105EJV Membrane TD68_01440 ENOG41067AE Membrane-bound metal-dependent hydrolase TD68_01445 ENOG4105CEN a g-specific adenine glycosylase TD68_01450 ENOG4106BXE TD68_01455 ENOG4105CAN Short-chain dehydrogenase reductase Sdr TD68_01470 ENOG4105EVI UPF0374 protein TD68_01475 ENOG4105BZ1 (ABC) transporter TD68_01480 ENOG4107NBY Membrane TD68_01490 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen TD68_01495 ENOG4105G5W regulator Fur family TD68_01500 ENOG4105TUA UPF0295 protein TD68_01605 ENOG4105E2A Dehydrogenase TD68_01610 ENOG4105PGS Spore coat protein TD68_01620 ENOG4108N23 SpoOM-related protein TD68_01625 ENOG4105EC3 peptidase S51, dipeptidase E TD68_01630 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) TD68_01645 ENOG4105E2Y ABC, transporter TD68_01650 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein TD68_01655 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component TD68_01665 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) TD68_01670 ENOG4107D63 TD68_01675 ENOG4105VZ8 Transcriptional regulator TD68_01690 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) TD68_01700 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) TD68_01720 ENOG4105CYN Serine protein kinase TD68_01725 ENOG4106AKX UPF0229 protein TD68_01730 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes TD68_01735 ENOG4105CW7 secretion protein, HlyD family TD68_01740 ENOG4105C0R drug resistance transporter emrb qaca subfamily TD68_01745 ENOG4105CS1 NAD(P)H quinone oxidoreductase TD68_01760 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family TD68_01765 ENOG4105CZV ABC transporter TD68_01770 ENOG4105CJ1 ABC, transporter TD68_01775 ENOG4108TU7 Inherit from COG: (ABC) transporter TD68_01780 ENOG4105VEQ Cold shock protein TD68_01790 ENOG4105BZU Histidine kinase TD68_01815 ENOG4105BZU Histidine kinase TD68_01830 ENOG4108YBP pseudouridine synthase TD68_01840 ENOG41080XP Cbs domain TD68_01845 ENOG4107YBY Hydrolase TD68_01850 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase TD68_01860 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) TD68_01865 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator TD68_01875 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) TD68_01880 ENOG4105C6V Glycerol-3-phosphate dehydrogenase TD68_01890 ENOG4105BZU Histidine kinase TD68_01895 ENOG4105WH1 Two component transcriptional regulator luxr family TD68_01930 ENOG4105ED1 spovr family TD68_01935 ENOG4105G6Z alkaline phosphatase TD68_01950 ENOG4105BZN citrate synthase TD68_01955 ENOG4105CYX Short-chain dehydrogenase reductase Sdr TD68_01960 ENOG4105CUB amino acid TD68_01965 ENOG4105C8J )-transporter TD68_01970 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TD68_01990 ENOG4105C26 Dehydrogenase TD68_01995 ENOG4105D82 Glutamate dehydrogenase TD68_02005 ENOG4105J37 TD68_02010 ENOG4108AEY RNA polymerase sigma factor TD68_02015 ENOG4108FN7 Aldo keto reductase TD68_02020 ENOG4105F6E Acyl-transferase TD68_02025 ENOG4107VFR oxidoreductase TD68_02030 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) TD68_02035 ENOG4105C37 (CBS) domain TD68_02045 ENOG4105C37 (CBS) domain TD68_02055 ENOG4105WMR Protein CrcB homolog TD68_02060 ENOG4108QXE glycerophosphoryl diester phosphodiesterase TD68_02065 ENOG4105D64 Mechanosensitive ion channel TD68_02070 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) TD68_02075 ENOG4107VMI polysaccharide deacetylase TD68_02080 ENOG4105F0I Aminotransferase TD68_02095 ENOG4105BZ1 (ABC) transporter TD68_02100 ENOG4105BZ1 (ABC) transporter TD68_02120 ENOG410839P TD68_02135 ENOG4106MP8 UPF0754 membrane protein TD68_02140 ENOG4105WZB UPF0342 protein TD68_02145 ENOG4105F1N DNA alkylation repair TD68_02155 ENOG4105D4P Coproporphyrinogen iii oxidase TD68_02165 ENOG4107S91 Sodium hydrogen exchanger TD68_02170 ENOG4105NCW Trka-c domain protein TD68_02180 ENOG4105CGU Enoyl-CoA hydratase TD68_02190 ENOG4108IUX (ABC) transporter TD68_02195 ENOG4105RHA ABC transporter, permease TD68_02200 ENOG4107VRP DNA repair exonuclease TD68_02205 ENOG4106D4I domain protein TD68_02210 ENOG4105EQI Metal Dependent Phosphohydrolase TD68_02220 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) TD68_02265 ENOG4105NBU tryptophan transport protein TD68_02270 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) TD68_02275 ENOG4105K59 histidine triad (HIT) protein TD68_02305 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation TD68_02310 ENOG4105BZ4 penicillin-binding protein TD68_02315 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) TD68_02320 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) TD68_02325 ENOG4105C1Q protoporphyrinogen oxidase TD68_02335 ENOG4105ECB domain protein TD68_02350 ENOG4105DER m42 family TD68_02360 ENOG4108RQ5 Beta-lactamase domain-containing protein TD68_02365 ENOG4105DF9 Lipoate-protein, ligase TD68_02375 ENOG4105CEY Amp-dependent synthetase and ligase TD68_02385 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 TD68_02390 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin TD68_02395 ENOG4105KD7 acetyltransferase TD68_02405 ENOG4108HUF Transporter TD68_02410 ENOG4105DQ5 transport system permease protein TD68_02415 ENOG4108U1V ABC transporter, permease TD68_02420 ENOG4107TB6 phosphoglycerate mutase TD68_02430 ENOG4105C1G acyl-Coa dehydrogenase TD68_02435 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase TD68_02440 ENOG4105C26 Dehydrogenase TD68_02445 ENOG41060WC Enoyl-CoA hydratase TD68_02455 ENOG4106YBV Methyl-accepting chemotaxis TD68_02475 ENOG4105XVF Competence transcription factor TD68_02480 ENOG4105X3H Excalibur domain protein TD68_02485 ENOG4105E1V na solute symporter TD68_02490 ENOG4106CAD Protein of unknown function (DUF3311) TD68_02495 ENOG41060YP TD68_02510 ENOG4107SCK Monooxygenase TD68_02515 ENOG4108INS Transcriptional regulator TD68_02520 ENOG4108KK1 membrane protein AbrB duplication TD68_02525 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding TD68_02540 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation TD68_02550 ENOG4105EYH Exonuclease TD68_02605 ENOG4105ERH Fumarylacetoacetate hydrolase TD68_02615 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin TD68_02625 ENOG4105CAQ asparagine synthetase TD68_02635 ENOG4105UQX Mate efflux family protein TD68_02640 ENOG4106HBX Transcriptional Regulator AraC Family TD68_02645 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) TD68_02650 ENOG4105ETE Transcriptional regulator (LacI family TD68_02655 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) TD68_02660 ENOG4105SF0 DinB family TD68_02670 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TD68_02675 ENOG4105MYW Pentapeptide repeat protein TD68_02685 ENOG4107S9D Alpha beta hydrolase TD68_02690 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) TD68_02695 ENOG4107RIQ Sulfate adenylate transferase TD68_02700 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) TD68_02705 ENOG4108N5B 2-phosphosulfolactate phosphatase TD68_02710 ENOG41061P3 phosphosulfolactate synthase TD68_02720 ENOG4105DIA mandelate racemase muconate lactonizing TD68_02725 ENOG4107RCC Major Facilitator Superfamily TD68_02735 ENOG4105MA6 gCN5-related N-acetyltransferase TD68_02745 ENOG4108VPT UPF0234 protein TD68_02750 ENOG4105QNR S1 RNA binding domain protein TD68_02760 ENOG410751J TD68_02765 ENOG4105EPR degv family TD68_02770 ENOG4107AYK membrAne TD68_02780 ENOG41073B9 TD68_02785 ENOG4108KP7 hydrolase TD68_02790 ENOG4108MXZ Esterase TD68_02795 ENOG4105VG1 fes assembly suf system protein TD68_02800 ENOG4105IQ5 FAD linked oxidase domain protein TD68_02810 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase TD68_02825 ENOG4105C8Y Acetylornithine aminotransferase TD68_02830 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain TD68_02840 ENOG4105DBV ornithine carbamoyltransferase TD68_02865 ENOG4107RMD Basic membrane lipoprotein TD68_02880 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) TD68_02885 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) TD68_02900 ENOG4108JQ7 (ABC) transporter TD68_02915 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TD68_02925 ENOG4105C31 Tryptophanyl-tRNA synthetase TD68_02930 ENOG4108J59 Extracellular solute-binding protein, family 5 TD68_02935 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TD68_02940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TD68_02950 ENOG4108JQ7 (ABC) transporter TD68_02970 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) TD68_02975 ENOG4108ZCF integral membrane protein TD68_02980 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis TD68_02990 ENOG4105DPN Oligoendopeptidase f TD68_03000 ENOG4105T58 Dithiol-disulfide isomerase TD68_03010 ENOG4105E4C Lytic transglycosylase catalytic TD68_03015 ENOG4105MIX Adenylate cyclase TD68_03030 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) TD68_03035 ENOG4105EMS pseudouridine synthase TD68_03040 ENOG4107S1Q Phosphatase TD68_03050 ENOG4105ETU transcriptional activator (TenA TD68_03055 ENOG4108VEU Thiamine monophosphate synthase TD68_03070 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) TD68_03075 ENOG4105D06 uba thif-type nad fad binding protein TD68_03080 ENOG4105DWF phosphomethylpyrimidine kinase TD68_03085 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH TD68_03090 ENOG4107A88 TD68_03135 ENOG4105ENA helicase TD68_03165 ENOG4108ZMI UPF0477 protein TD68_03175 ENOG4105C28 cystathionine TD68_03180 ENOG4105C28 cystathionine TD68_03185 ENOG4105JHY Membrane TD68_03205 ENOG41068SY TD68_03245 ENOG4105WFK nuclease TD68_03250 ENOG4105KT7 mgtC SapB transporter TD68_03270 ENOG4108ZJ4 polysaccharide deacetylase TD68_03275 ENOG4107CUJ Protein of unknown function (DUF2690) TD68_03290 ENOG4108IEG Formate dehydrogenase Alpha subunit TD68_03315 ENOG4106A3M Cytochrome p-450 TD68_03320 ENOG41087PP glycosyltransferase MGT family TD68_03340 ENOG4105EXQ uroporphyrinogen iii synthase hem4 TD68_03345 ENOG4105C4B ABC transporter, permease TD68_03350 ENOG4108IXI (ABC) transporter TD68_03360 ENOG4105Q95 Cupin 2, conserved barrel domain protein TD68_03375 ENOG4105D2H Uronic isomerase TD68_03380 ENOG4105CT4 transporter TD68_03385 ENOG4107KJX Transcriptional regulator TD68_03390 ENOG4107QZW Altronate oxidoreductase TD68_03395 ENOG4105CTX dehydratase TD68_03400 ENOG4107TSN permease TD68_03420 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase TD68_03425 ENOG4105KWG Pfam:DUF1696 TD68_03430 ENOG4105K7W phage-related replication protein TD68_03435 ENOG410635T phage-like element pbsx protein TD68_03475 ENOG4108TFU terminase (Small subunit) TD68_03480 ENOG4105IG6 Phage terminase, large subunit TD68_03485 ENOG4108MDF Phage Portal Protein TD68_03510 ENOG41060SN TD68_03525 ENOG4105PQS phage protein TD68_03530 ENOG4105FR7 XkdM protein, phage-like element PBSX TD68_03535 ENOG4105MTC XkdN-like protein TD68_03540 ENOG4108FKH Transglycosylase SLT domain TD68_03545 ENOG4108WZM domain protein TD68_03550 ENOG4105X7F TD68_03560 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase TD68_03565 ENOG4105MFU Protein of unknown function (DUF2634) TD68_03570 ENOG41066EA baseplate J family protein TD68_03575 ENOG410906S phage-like element pbsx protein xkdt TD68_03585 ENOG41068G1 TD68_03615 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase TD68_03630 ENOG4105CJ3 phosphate transporter TD68_03635 ENOG4107GRR phosphate transport regulator TD68_03640 ENOG4107R7I amino acid TD68_03650 ENOG4105EDW glycosyl transferase, family 39 TD68_03655 ENOG4105CKK Glycosyl transferase, family 2 TD68_03665 ENOG4105C0H protease TD68_03675 ENOG4108ME1 Peptidase M55 D-aminopeptidase TD68_03680 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TD68_03685 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TD68_03690 ENOG4105C3U ABC transporter TD68_03700 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A TD68_03705 ENOG4105DTQ mandelate racemase muconate lactonizing TD68_03710 ENOG4107SN7 NLP P60 protein TD68_03715 ENOG4108JQ7 (ABC) transporter TD68_03720 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) TD68_03725 ENOG4107TUM Amidinotransferase TD68_03730 ENOG4108S4H thioesterase Superfamily protein TD68_03740 ENOG4105K7K Transcriptional regulator TD68_03760 ENOG4108428 Inherit from COG: -acetyltransferase TD68_03770 ENOG41080TC multidrug resistance protein TD68_03775 ENOG4105CIY formyltetrahydrofolate deformylase TD68_03780 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) TD68_03795 ENOG4105K56 Transcriptional regulator TD68_03800 ENOG4108ZHJ Organic hydroperoxide resistance protein TD68_03815 ENOG4107TVC Glycosyl transferase, family 2 TD68_03825 ENOG4107Y2X deaminase TD68_03830 ENOG4105CVJ phosphoglycerate mutase TD68_03835 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) TD68_03840 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin TD68_03850 ENOG4108W7F transporter, permease TD68_03855 ENOG4108JJB ABC transporter TD68_03860 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein TD68_03865 ENOG4108X43 YKOF domain protein TD68_03870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TD68_03875 ENOG41062D9 Histidine kinase TD68_03885 ENOG4106849 propeptide, pepSY amd peptidase M4 TD68_03890 ENOG4105CJW magnesium transporter TD68_03895 ENOG4105V75 Transcriptional regulator TD68_03940 ENOG4105DQE DNA ligase TD68_03945 ENOG4105FDF Could be involved in DNA repair (By similarity) TD68_03950 ENOG4105BZU Histidine kinase TD68_03955 ENOG4105BZU Histidine kinase TD68_03960 ENOG4105BZU Histidine kinase TD68_03965 ENOG4107T5V SNARE associated Golgi TD68_03970 ENOG4107TS3 membrane protein, TerC TD68_03975 ENOG4108WZW RNA polymerase sigma TD68_03985 ENOG410681C small acid-soluble spore protein TD68_03995 ENOG4105D0M Protease HtpX homolog TD68_04005 ENOG410900G Protein of unknown function (DUF421) TD68_04010 ENOG4108TGC Acyltransferase TD68_04015 ENOG4105BZU Histidine kinase TD68_04020 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) TD68_04025 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) TD68_04030 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) TD68_04035 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase TD68_04045 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit TD68_04050 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) TD68_04055 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) TD68_04060 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) TD68_04080 ENOG4105BZU Histidine kinase TD68_04085 ENOG41090MY MarR family Transcriptional regulator TD68_04090 ENOG4105ER2 Ompa motb domain protein TD68_04095 ENOG4105E14 MotA TolQ exbB proton channel TD68_04105 ENOG4108K88 Membrane TD68_04115 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) TD68_04120 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase TD68_04125 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) TD68_04130 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) TD68_04145 ENOG4108MK9 spermidine N(1)-acetyltransferase TD68_04160 ENOG4105F0V Cell wall hydrolase TD68_04175 ENOG4105C59 p-type ATPase TD68_04185 ENOG4105DC7 peptidase M24 TD68_04195 ENOG4105CID antiterminator TD68_04205 ENOG4105KRI phosphocarrier protein (HPr TD68_04210 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) TD68_04220 ENOG4105F6S Spore photoproduct lyase TD68_04230 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer TD68_04235 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase TD68_04240 ENOG4105K4I Scp-like extracellular TD68_04250 ENOG4105BZU Histidine kinase TD68_04255 ENOG4105CHM Aminotransferase TD68_04260 ENOG4107R88 Chemotaxis protein (CheV) TD68_04265 ENOG4105UIN TD68_04275 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein TD68_04285 ENOG4105K6S Short-chain dehydrogenase reductase Sdr TD68_04290 ENOG4105EPM Diguanylate phosphodiesterase TD68_04295 ENOG4105WEF catalase TD68_04300 ENOG4107IN1 Protein of unknown function (DUF1797) TD68_04305 ENOG4108XRC Protein of unknown function (DUF458) TD68_04335 ENOG4105NQC Flavodoxin TD68_04345 ENOG4105CH2 amidohydrolase TD68_04355 ENOG4105D8X mechanosensitive ion channel TD68_04360 ENOG4105D3R alkyl hydroperoxide reductase TD68_04365 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen TD68_04380 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) TD68_04385 ENOG4105D06 uba thif-type nad fad binding protein TD68_04390 ENOG4105CVM Molybdenum cofactor synthesis domain protein TD68_04395 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein TD68_04400 ENOG4108ZAF Molybdopterin TD68_04405 ENOG41067WU Molybdopterin converting factor (Subunit 1) TD68_04410 ENOG4105BZ1 (ABC) transporter TD68_04415 ENOG4105BZ1 (ABC) transporter TD68_04425 ENOG4107X8C Efflux transporter RND family MFP subunit TD68_04430 ENOG4105C19 ABC transporter TD68_04435 ENOG4107RBB ABC transporter, permease TD68_04440 ENOG4105E98 transcriptional regulator DeoR family TD68_04445 ENOG4105DE4 1-phosphofructokinase TD68_04450 ENOG4105DM4 PTS System TD68_04455 ENOG4105C3F Signal peptidase i TD68_04465 ENOG4105C5H ABC transporter TD68_04470 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) TD68_04490 ENOG4105BZU Histidine kinase TD68_04500 ENOG4107ZYR domain protein TD68_04510 ENOG4105CN5 Metallo-Beta-Lactamase TD68_04515 ENOG4106148 UPF0356 protein TD68_04520 ENOG4108X4Q Hydrolase TD68_04525 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) TD68_04545 ENOG4105CPP Dehydrogenase, E1 component TD68_04550 ENOG4105C7S Dehydrogenase TD68_04555 ENOG4107QN2 dihydrolipoyl dehydrogenase TD68_04570 ENOG4105CXN decarboxylase TD68_04575 ENOG4105WBI UPF0223 protein TD68_04590 ENOG4105ECY inositol monophosphatase TD68_04600 ENOG4105JQZ Methyltransferase TD68_04640 ENOG4105CI3 gtp-binding protein typa TD68_04645 ENOG4105QA2 TD68_04660 ENOG4108IAB Phoh family TD68_04670 ENOG4105CSV Glutaminase TD68_04675 ENOG4105ZPI UPF0358 protein TD68_04680 ENOG4105CNI cell division protein FtsW TD68_04685 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) TD68_04695 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) TD68_04705 ENOG4105BZ9 Cytochrome C oxidase, subunit I TD68_04710 ENOG4105CCU oxidase (Subunit III) TD68_04715 ENOG41064X9 cytochrome C oxidase subunit IV TD68_04730 ENOG41080XQ Signal transduction protein with cbs domains TD68_04735 ENOG4106UY4 Inherit from COG: Scp-like extracellular TD68_04760 ENOG4105WUC UPF0298 protein TD68_04765 ENOG4106H78 methyltransferase TD68_04770 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) TD68_04775 ENOG4105H20 Sporulation integral membrane protein YlbJ TD68_04780 ENOG4105D78 K07001 NTE family protein TD68_04785 ENOG41063PX domain protein TD68_04790 ENOG4105CDE UPF0348 protein TD68_04795 ENOG4105KNH Nucleic acid-binding protein TD68_04800 ENOG41067VY 50S ribosomal protein L32 TD68_04825 ENOG4108V6E Cell division protein mraZ TD68_04830 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) TD68_04840 ENOG4105CJN penicillin-binding protein TD68_04845 ENOG4105CJN penicillin-binding protein TD68_04850 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) TD68_04855 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) TD68_04860 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) TD68_04865 ENOG4105CNI cell division protein FtsW TD68_04870 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) TD68_04875 ENOG4105D4A Cell wall formation (By similarity) TD68_04880 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) TD68_04885 ENOG4108R2U division initiation protein TD68_04895 ENOG4105K67 small basic protein TD68_04900 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) TD68_04905 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) TD68_04915 ENOG4105FFI sigma-e processing peptidase spoiiga TD68_04920 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TD68_04930 ENOG4105DKW ABC transporter TD68_04940 ENOG4105WR5 sporulation protein, YlmC YmxH family TD68_04945 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase TD68_04950 ENOG4105DFA alanine racemase domain protein TD68_04955 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) TD68_04960 ENOG41067XK integral membrane protein TD68_04965 ENOG4105DBK s4 domain protein TD68_04975 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) TD68_04985 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) TD68_04990 ENOG4105C34 Pseudouridine synthase TD68_04995 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) TD68_05005 ENOG4105CXT aspartate transcarbamylase TD68_05015 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain TD68_05020 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain TD68_05025 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) TD68_05030 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) TD68_05035 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) TD68_05040 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) TD68_05045 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) TD68_05055 ENOG4107S4M Sulfate adenylate transferase TD68_05060 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) TD68_05065 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) TD68_05070 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein TD68_05075 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein TD68_05080 ENOG4105F23 Fibronectin-binding protein TD68_05090 ENOG4105DSJ YicC domain protein TD68_05095 ENOG4105KC4 UPF0296 protein TD68_05100 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) TD68_05110 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase TD68_05115 ENOG4105C25 Primosomal protein n' TD68_05120 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) TD68_05125 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) TD68_05130 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B TD68_05135 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs TD68_05140 ENOG4108ZF3 Phosphatase TD68_05145 ENOG4105D9P serine threonine protein kinase TD68_05150 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) TD68_05155 ENOG4105DJV ribulose-phosphate 3-epimerase TD68_05160 ENOG4105FJ0 thiamine TD68_05170 ENOG4105VB9 50S ribosomal protein l28 TD68_05175 ENOG4108ZAA Alkaline-shock protein TD68_05180 ENOG4105DP4 dak2 domain fusion protein ylov TD68_05190 ENOG4105EJQ L-serine dehydratase TD68_05195 ENOG4105CB5 ATP-dependent DNA helicase recG TD68_05200 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) TD68_05205 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) TD68_05210 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase TD68_05215 ENOG4105CHR reductase TD68_05220 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) TD68_05225 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) TD68_05230 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) TD68_05235 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) TD68_05240 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) TD68_05250 ENOG4105K5M 30s ribosomal protein S16 TD68_05255 ENOG4108BW8 UPF0109 protein TD68_05265 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) TD68_05270 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) TD68_05275 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) TD68_05280 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) TD68_05285 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) TD68_05295 ENOG4105VM1 flagellar TD68_05300 ENOG4105CMV Succinyl-CoA synthetase subunit beta TD68_05305 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha TD68_05310 ENOG4105C79 DNA protecting protein DprA TD68_05315 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) TD68_05320 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) TD68_05325 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TD68_05330 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) TD68_05335 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) TD68_05345 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) TD68_05350 ENOG4108ZC9 flagellar basal-body rod protein flgc TD68_05355 ENOG4105VQ0 flagellar hook-basal body complex protein fliE TD68_05360 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) TD68_05365 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) TD68_05380 ENOG4106YF4 Flagellar biosynthesis chaperone TD68_05390 ENOG410696Y Flagellar hook-length control protein TD68_05395 ENOG410822I Flagellar hook capping protein TD68_05400 ENOG4108JQA flagellar TD68_05405 ENOG41068WV flagellar FlbD family protein TD68_05415 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) TD68_05420 ENOG4105DD5 Flagellar motor switch protein TD68_05425 ENOG4107YTP response regulator receiver protein TD68_05435 ENOG4105CN7 Flagellar biosynthetic protein FliP TD68_05440 ENOG4105VS8 Flagellar biosynthetic protein fliq TD68_05445 ENOG4105D19 Role in flagellar biosynthesis (By similarity) TD68_05450 ENOG4105D00 flagellar biosynthetic protein flhB TD68_05455 ENOG4105D7B Flagellar biosynthesis protein flha TD68_05460 ENOG4105FZW flagellar biosynthesis regulator FlhF TD68_05470 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) TD68_05475 ENOG4105CBS Chea signal transduction histidine kinase TD68_05480 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis TD68_05495 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TD68_05505 ENOG4105CE9 30S ribosomal protein S2 TD68_05510 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) TD68_05520 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) TD68_05525 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) TD68_05530 ENOG4105KNE Phosphatidate cytidylyltransferase TD68_05540 ENOG4105DZP Membrane-associated zinc metalloprotease TD68_05545 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) TD68_05550 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) TD68_05555 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) TD68_05560 ENOG4105CHV Transcription elongation factor NusA TD68_05565 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination TD68_05570 ENOG4105VHM ribosomal protein TD68_05575 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) TD68_05580 ENOG4105W7A Protein of unknown function (DUF503) TD68_05585 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) TD68_05590 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) TD68_05595 ENOG4105DTN riboflavin biosynthesis protein ribF TD68_05600 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) TD68_05605 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) TD68_05615 ENOG4105C1V Peptidase, M16 TD68_05625 ENOG4105E35 Dipicolinate synthase subunit A TD68_05630 ENOG4108S0H Dipicolinic acid synthetase, b subunit TD68_05635 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) TD68_05645 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) TD68_05655 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit TD68_05665 ENOG4105CNU cell division protein FtsK TD68_05670 ENOG4105FDP GntR family transcriptional regulator TD68_05690 ENOG4108RKS Short-chain dehydrogenase reductase Sdr TD68_05695 ENOG4105XZV Protein of unknown function (DUF3243) TD68_05710 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase TD68_05715 ENOG4105CEV competence damage-inducible protein TD68_05725 ENOG4108A04 Beta-lactamase TD68_05735 ENOG4105D48 metallophosphoesterase TD68_05740 ENOG4105MCT stage V sporulation protein S TD68_05750 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) TD68_05760 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) TD68_05775 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) TD68_05780 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) TD68_05790 ENOG4105IIP Membrane TD68_05795 ENOG4105W1N transcriptional regulator TD68_05800 ENOG4108151 Beta-lactamase domain protein TD68_05805 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase TD68_05815 ENOG4107QKG PfaD family TD68_05820 ENOG41062T2 Acyl carrier protein TD68_05825 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase TD68_05830 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase TD68_05835 ENOG4108MGH Enoyl-CoA hydratase TD68_05840 ENOG4108KQ6 Enoyl-CoA hydratase TD68_05845 ENOG4105C0W non-ribosomal peptide synthetase TD68_05850 ENOG4107SQU synthase TD68_05860 ENOG4105C0W non-ribosomal peptide synthetase TD68_05870 ENOG4106A3M Cytochrome p-450 TD68_05880 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin TD68_05890 ENOG4105K7W phage-related replication protein TD68_05895 ENOG4108X3M OsmC Ohr family protein TD68_05925 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) TD68_05945 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) TD68_05950 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) TD68_05955 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) TD68_05960 ENOG4105U6W MutT NUDIX family protein TD68_05965 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase TD68_05970 ENOG4106F1P AAA ATPase, central domain protein TD68_05975 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) TD68_05980 ENOG4105CXI aluminum resistance protein TD68_05985 ENOG4105KV4 Transcriptional regulator TD68_05990 ENOG4105C5F glutamine synthetase TD68_06005 ENOG4108U7W acetyltransferase TD68_06010 ENOG4107Y9E nuclease TD68_06020 ENOG4106BHF TD68_06025 ENOG4106ANW SMI1_KNR4 TD68_06035 ENOG4105UA4 acetyltransferase TD68_06055 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase TD68_06075 ENOG4108RZ2 Glycoside hydrolase family 16 TD68_06125 ENOG4105CPC Aldo Keto reductase TD68_06150 ENOG4108J4B Beta-lactamase TD68_06155 ENOG4105FEA Spore maturation protein TD68_06170 ENOG41073R8 VanW family TD68_06185 ENOG41083Q9 chitosanase TD68_06210 ENOG41090E6 transcriptional regulator MERR family TD68_06215 ENOG4108ZMQ domain protein TD68_06230 ENOG4108RAV Conserved protein TD68_06245 ENOG410780I phosphoprotein phosphatase activity TD68_06260 ENOG4105CJ1 ABC, transporter TD68_06275 ENOG41075D4 Aminoglycoside 6-adenylyltransferase TD68_06305 ENOG4105K7W phage-related replication protein TD68_06310 ENOG4105XPP Protein of unknown function (DUF1275) TD68_06325 ENOG4105FVX TD68_06330 ENOG4105K7W phage-related replication protein TD68_06355 ENOG4105PGS Spore coat protein TD68_06365 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) TD68_06375 ENOG4108SVB resolvase TD68_06380 ENOG4105VPS UPF0291 protein TD68_06385 ENOG4105CV1 Transketolase (EC 2.2.1.1) TD68_06395 ENOG4105VXM UPF0154 protein TD68_06405 ENOG4107QIV Cytochrome c biogenesis protein TD68_06430 ENOG4107DZX Small, acid-soluble spore protein P TD68_06440 ENOG4108I0Z Aconitate hydratase TD68_06445 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen TD68_06455 ENOG41067CD Small, acid-soluble spore protein Tlp TD68_06465 ENOG4105MI2 TD68_06470 ENOG4105W8X HesB YadR YfhF-family protein TD68_06475 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) TD68_06480 ENOG4105K4P CoA-binding domain protein TD68_06485 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TD68_06510 ENOG4108KXV response regulator TD68_06520 ENOG4107SYN Glycosyl hydrolases family 43 TD68_06535 ENOG4107T5V SNARE associated Golgi TD68_06545 ENOG4107QX3 carboxylase TD68_06550 ENOG4105E39 Enoyl-CoA hydratase TD68_06555 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase TD68_06560 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit TD68_06565 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase TD68_06570 ENOG4105CEY Amp-dependent synthetase and ligase TD68_06575 ENOG4105C1G acyl-Coa dehydrogenase TD68_06580 ENOG4105F32 YngK protein TD68_06585 ENOG4106U2H Protein of unknown function (DUF1360) TD68_06595 ENOG4105CEY Amp-dependent synthetase and ligase TD68_06600 ENOG4105C0W non-ribosomal peptide synthetase TD68_06610 ENOG4105C0W non-ribosomal peptide synthetase TD68_06615 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) TD68_06620 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family TD68_06625 ENOG4108N2V aldose 1-epimerase TD68_06635 ENOG41086D8 Transcriptional regulator TD68_06650 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase TD68_06670 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) TD68_06675 ENOG4108KSA LysR family transcriptional regulator TD68_06680 ENOG4105CB2 alcohol dehydrogenase TD68_06685 ENOG4105BZ8 glutamate synthase TD68_06690 ENOG4105CBC glutamate synthase TD68_06695 ENOG4105C5Q Transcriptional regulator TD68_06700 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) TD68_06755 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) TD68_06765 ENOG4107RB3 L-asparaginase TD68_06770 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) TD68_06775 ENOG4105KME endoribonuclease L-psp TD68_06810 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) TD68_06855 ENOG4108V4B ThiJ pfpI TD68_07025 ENOG4107D0N TD68_07030 ENOG4107D0N TD68_07085 ENOG4107NTZ TD68_07115 ENOG4108NE4 TD68_07130 ENOG41067QW Transcriptional regulator TD68_07150 ENOG4105K70 DNA-binding protein TD68_07265 ENOG41068G1 TD68_07280 ENOG4107VXM glycerophosphoryl diester phosphodiesterase TD68_07310 ENOG4105E4C Lytic transglycosylase catalytic TD68_07315 ENOG4105E4C Lytic transglycosylase catalytic TD68_07325 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) TD68_07360 ENOG4108V4B ThiJ pfpI TD68_07380 ENOG4105IE8 Alpha-ketoglutarate permease TD68_07385 ENOG4107U6E carbohydrate kinase FGGY TD68_07390 ENOG4108M3J Dehydrogenase TD68_07395 ENOG4108J2R molybdopterin oxidoreductase TD68_07410 ENOG4108IG5 Transcriptional regulator TD68_07415 ENOG4108Z7R Chaperone CsaA TD68_07420 ENOG4105FTV AraC Family Transcriptional Regulator TD68_07430 ENOG4108W8B Beta-lactamase domain protein TD68_07440 ENOG4105D29 Helix-turn-helix type 11 domain protein TD68_07450 ENOG4105KTU Transcriptional regulator, arsr family TD68_07460 ENOG4108SJC Membrane TD68_07475 ENOG4105ECK Fatty Acid Desaturase TD68_07480 ENOG4108ZGX Histidine kinase TD68_07485 ENOG4108S01 response regulator TD68_07495 ENOG41069ER domain protein TD68_07500 ENOG4105C9U ATP-dependent DNA helicase RecQ TD68_07505 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) TD68_07510 ENOG4105SCY DNAK suppressor TD68_07525 ENOG4105C26 Dehydrogenase TD68_07530 ENOG4105EWU Squalene--hopene cyclase TD68_07535 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) TD68_07540 ENOG4105C8J )-transporter TD68_07545 ENOG4105C09 Bile acid TD68_07550 ENOG4105C7S Dehydrogenase TD68_07560 ENOG4107T89 von Willebrand factor, type A TD68_07565 ENOG4105GMT ATPase associated with various cellular activities aaa_5 TD68_07575 ENOG4105K4H Nlp p60 protein TD68_07580 ENOG41087PP glycosyltransferase MGT family TD68_07590 ENOG4107QMU Mate efflux family protein TD68_07595 ENOG4106SCS STAS domain TD68_07615 ENOG4105FR1 rard protein TD68_07645 ENOG41090U3 tautomerase TD68_07660 ENOG4105FBA Phospholipase Carboxylesterase TD68_07675 ENOG4105E1V na solute symporter TD68_07695 ENOG4108VXD carboxy-peptidase TD68_07700 ENOG4105D3A purine nucleoside phosphorylase DeoD-type TD68_07705 ENOG4106Z5R TD68_07710 ENOG410841Q phosphoesterase PA-phosphatase related protein TD68_07735 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein TD68_07740 ENOG4108TSC N-acetyltransferase TD68_07745 ENOG4107S4Y M20 DapE family protein YgeY TD68_07760 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) TD68_07795 ENOG4107T32 3-phytase (EC 3.1.3.8) TD68_07800 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) TD68_07810 ENOG4108M1A Chitin-binding protein TD68_07820 ENOG4105VMP Transcriptional regulator TD68_07825 ENOG4105NX3 Membrane TD68_07830 ENOG41086D8 Transcriptional regulator TD68_07845 ENOG4105E0X reductase TD68_07850 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) TD68_07870 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) TD68_07875 ENOG41090WU lipolytic protein G-D-S-L family TD68_07880 ENOG4108KF3 Electron transport protein SCO1 SenC TD68_07890 ENOG4105C7B Threonine dehydratase TD68_07900 ENOG4108UT2 hemolysin iii TD68_07910 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) TD68_07915 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) TD68_07930 ENOG4107YX5 Pfam:DUF548 TD68_07935 ENOG4108Y6J UPF0403 protein TD68_07940 ENOG4105C01 Dihydroxy-acid dehydratase TD68_07955 ENOG4108V06 Glutathione peroxidase TD68_07960 ENOG4105CVG Homoserine O-transsuccinylase TD68_08000 ENOG41081VK Ribonuclease TD68_08020 ENOG410890F Dynamin family TD68_08030 ENOG41065KQ synthase TD68_08035 ENOG4105C2W permease TD68_08040 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) TD68_08045 ENOG4105CTD carboxy-peptidase TD68_08050 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) TD68_08055 ENOG4108UHU Aldolase TD68_08060 ENOG4105D7K pfkb domain protein TD68_08065 ENOG4108M60 Transcriptional regulator TD68_08075 ENOG4105CHR reductase TD68_08080 ENOG4105DVT helicase TD68_08090 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) TD68_08100 ENOG4108UKS UPF0398 protein TD68_08105 ENOG4107X2U Inherit from COG: Exonuclease-like protein TD68_08110 ENOG4108I5C dEAD DEAH box helicase TD68_08160 ENOG4105BZ4 penicillin-binding protein TD68_08170 ENOG4105CSM endonuclease III TD68_08180 ENOG4105C5S asparaginyl-tRNA synthetase TD68_08185 ENOG4105CHM Aminotransferase TD68_08195 ENOG4105DVT helicase TD68_08200 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) TD68_08205 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) TD68_08210 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) TD68_08220 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase TD68_08225 ENOG4105DJ0 Poly(A) Polymerase TD68_08230 ENOG4105CPK Glycosyl transferase (Group 1 TD68_08235 ENOG4105FJR Lmbe family TD68_08240 ENOG4108Z5K methylglyoxal synthase TD68_08245 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) TD68_08250 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase TD68_08255 ENOG4108JYZ YitT family TD68_08260 ENOG4105F0F Oxalate decarboxylase TD68_08280 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) TD68_08300 ENOG41068YB TPR repeat-containing protein TD68_08305 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase TD68_08315 ENOG4105CIH Imidazole acetol-phosphate transaminase TD68_08325 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) TD68_08330 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase TD68_08340 ENOG4108I0Q anthranilate phosphoribosyltransferase TD68_08345 ENOG4105CRQ synthase (Component I) TD68_08350 ENOG4105KHN chorismate mutase TD68_08355 ENOG4105D49 3-dehydroquinate synthase TD68_08360 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase TD68_08365 ENOG4105BZU Histidine kinase TD68_08370 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) TD68_08375 ENOG4105EAH synthase TD68_08380 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) TD68_08385 ENOG4105XXQ heptaprenyl diphosphate synthase component I TD68_08395 ENOG4105EUJ GTP cyclohydrolase i TD68_08400 ENOG4105K70 DNA-binding protein TD68_08405 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) TD68_08420 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase TD68_08425 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) TD68_08430 ENOG41065D1 TD68_08435 ENOG4105S2F TD68_08445 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) TD68_08450 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) TD68_08455 ENOG4105CAT Cytidine monophosphate kinase TD68_08465 ENOG4105MSI germination protein ypeb TD68_08475 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) TD68_08480 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase TD68_08495 ENOG4107RGJ metallophosphoesterase TD68_08510 ENOG4105I7S Abortive infection protein TD68_08515 ENOG4105C9U ATP-dependent DNA helicase RecQ TD68_08520 ENOG4105T7X TD68_08530 ENOG4108SAX Membrane TD68_08535 ENOG4108JQ1 Dehydrogenase TD68_08540 ENOG4105FF2 Type I DHQase TD68_08555 ENOG4105BZU Histidine kinase TD68_08560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TD68_08565 ENOG4105CRE cytochrome C TD68_08570 ENOG4107TWT Cytochrome c biogenesis protein TD68_08580 ENOG4105FE9 pseudouridine synthase TD68_08590 ENOG4108JIC nucleoside recognition domain protein TD68_08595 ENOG4105DZ1 carboxypeptidase TD68_08605 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) TD68_08610 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) TD68_08625 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) TD68_08630 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) TD68_08635 ENOG4108R6K riboflavin synthase, subunit alpha TD68_08640 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) TD68_08655 ENOG4105C3F Signal peptidase i TD68_08660 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) TD68_08680 ENOG4108M26 parallel beta-helix repeat protein TD68_08690 ENOG4107ZE5 PPIases accelerate the folding of proteins TD68_08700 ENOG4107ZE5 PPIases accelerate the folding of proteins TD68_08735 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) TD68_08790 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) TD68_08805 ENOG4105C2M dna polymerase I TD68_08820 ENOG4105ZMH deoxynucleoside kinase TD68_08830 ENOG4107T8J thymidine kinase TD68_08845 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) TD68_08905 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase TD68_08910 ENOG4105XSJ toxin secretion phage lysis holin TD68_09045 ENOG410780I phosphoprotein phosphatase activity TD68_09070 ENOG4105PTM secreted protein TD68_09075 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) TD68_09085 ENOG4105G6R Stage v sporulation protein ae TD68_09095 ENOG4105CZ3 stage V sporulation protein ad TD68_09100 ENOG41090VF Stage v sporulation protein ac TD68_09115 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TD68_09120 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) TD68_09125 ENOG41082AN stage II sporulation protein TD68_09130 ENOG4105DZ1 carboxypeptidase TD68_09135 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) TD68_09140 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) TD68_09145 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TD68_09155 ENOG4105I3K Ferric uptake regulator, Fur family TD68_09160 ENOG4105MZ9 stage II sporulation protein m TD68_09175 ENOG4105DFD Na H antiporter TD68_09180 ENOG4108IJ0 Aspartate ammonia-lyase TD68_09185 ENOG4105HDK L-asparaginase TD68_09190 ENOG4108IMY Transcriptional regulator TD68_09200 ENOG4108YZ4 nudix hydrolase TD68_09210 ENOG4105CPC Aldo Keto reductase TD68_09230 ENOG4106HZJ TD68_09235 ENOG4105RHY Pfam:UPF0157 TD68_09245 ENOG4108XET gCN5-related N-acetyltransferase TD68_09255 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) TD68_09265 ENOG4105C02 permease TD68_09270 ENOG4105E5W Transporter TD68_09275 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase TD68_09290 ENOG4108IXY short-chain dehydrogenase reductase TD68_09295 ENOG41069FQ Metallo-beta-lactamase superfamily TD68_09300 ENOG4105II7 pyrroline-5-carboxylate reductase TD68_09310 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase TD68_09320 ENOG410861F 50S ribosomal protein L33 TD68_09325 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) TD68_09330 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase TD68_09335 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) TD68_09340 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) TD68_09350 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) TD68_09355 ENOG4108NA0 Uncharacterized conserved protein (COG2071) TD68_09360 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) TD68_09365 ENOG4108HNZ carboxyl transferase TD68_09370 ENOG4108ZVT methylmalonyl-coA epimerase TD68_09375 ENOG4108VZI ErfK ybiS ycfS ynhG family protein TD68_09380 ENOG4108QEG Membrane TD68_09385 ENOG4105CDA abc transporter atp-binding protein TD68_09390 ENOG4105E5Q amino acid AbC transporter TD68_09395 ENOG4108HW3 (ABC) transporter TD68_09400 ENOG4108Y6J UPF0403 protein TD68_09405 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) TD68_09415 ENOG4105C7S Dehydrogenase TD68_09420 ENOG4105CPP Dehydrogenase, E1 component TD68_09435 ENOG4105CKM Branched-chain carboxylic acid kinase TD68_09440 ENOG4107RDP Dehydrogenase TD68_09450 ENOG4108JUB Transcriptional regulator TD68_09455 ENOG4106CCJ Protein of unknown function (DUF2627) TD68_09460 ENOG4105CR4 methylisocitrate lyase TD68_09465 ENOG4105DXD 2-methylcitrate dehydratase TD68_09475 ENOG4105C1G acyl-Coa dehydrogenase TD68_09480 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase TD68_09490 ENOG4108QXE glycerophosphoryl diester phosphodiesterase TD68_09495 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase TD68_09505 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase TD68_09515 ENOG4107QQR Sporulation TD68_09520 ENOG4105S1Z Stage IV sporulation protein B TD68_09525 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) TD68_09530 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) TD68_09535 ENOG4105DX0 Hemolysin A TD68_09545 ENOG4105CTB Polyprenyl synthetase TD68_09550 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) TD68_09555 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) TD68_09560 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) TD68_09565 ENOG4105M7K Involved in the transcription termination process (By similarity) TD68_09570 ENOG4108ZSR alkaline shock protein TD68_09575 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase TD68_09595 ENOG410644B Stage III sporulation protein af TD68_09605 ENOG4105KQ4 Stage iii sporulation protein ad TD68_09610 ENOG4108CQH stage III sporulation protein AC TD68_09615 ENOG4105KR5 Stage iii sporulation protein TD68_09620 ENOG4105CD2 stage iii sporulation protein aa TD68_09630 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) TD68_09635 ENOG4105DC7 peptidase M24 TD68_09640 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) TD68_09650 ENOG4105CBJ Metal-dependent enzyme TD68_09665 ENOG4105KST dependent repressor TD68_09670 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) TD68_09675 ENOG4105WZW rhodanese family TD68_09680 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor TD68_09685 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor TD68_09690 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) TD68_09695 ENOG4105C0D helicase TD68_09710 ENOG4108IMY Transcriptional regulator TD68_09720 ENOG4105VFR signal peptidase TD68_09780 ENOG4105C37 (CBS) domain TD68_09805 ENOG4105C5X domain protein TD68_09830 ENOG4105E0M Sulfatase TD68_09845 ENOG4107ZXI Rhomboid family TD68_09850 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase TD68_09870 ENOG41068DG YceG-like family TD68_09875 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) TD68_09880 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) TD68_09885 ENOG4105E2Z phosphate ABC transporter (Permease TD68_09890 ENOG4105C8U phosphate abc transporter TD68_09895 ENOG4105CVA phosphate TD68_09900 ENOG4107RF6 penicillin-binding protein TD68_09910 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) TD68_09915 ENOG4105SXS Protein of unknown function (DUF456) TD68_09930 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) TD68_09935 ENOG41063Y9 TD68_09940 ENOG4108U5J '-nucleotidase TD68_09945 ENOG4105N80 Ferric uptake regulator, Fur family TD68_09950 ENOG4108JYZ YitT family TD68_09955 ENOG41069ZM Protein of unknown function (DUF2624) TD68_09960 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) TD68_09975 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) TD68_09980 ENOG4105EGD dinuclear metal center protein, YbgI family TD68_09995 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TD68_10000 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) TD68_10005 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 TD68_10010 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) TD68_10020 ENOG4105C38 Glycyl-tRNA synthetase beta subunit TD68_10025 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit TD68_10030 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) TD68_10035 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) TD68_10040 ENOG4105KG3 cytidine deaminase TD68_10045 ENOG4107YR5 Diacylglycerol kinase TD68_10050 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) TD68_10055 ENOG4105CTJ Metal Dependent Phosphohydrolase TD68_10060 ENOG4105C9A Phoh family TD68_10065 ENOG4105EI1 sporulation protein yqfd TD68_10070 ENOG41068P3 sporulation protein YqfC TD68_10080 ENOG4105DI5 UPF0365 protein TD68_10085 ENOG4105F7J membrane-bound serine protease TD68_10090 ENOG4105KTH gatB Yqey TD68_10105 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) TD68_10110 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) TD68_10115 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) TD68_10120 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) TD68_10125 ENOG4105CFG Acts as a chaperone (By similarity) TD68_10130 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ TD68_10135 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) TD68_10140 ENOG4105CSA Coproporphyrinogen iii oxidase TD68_10145 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) TD68_10155 ENOG4108ZRV stage ii sporulation protein p TD68_10160 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) TD68_10165 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) TD68_10170 ENOG4105TQK DNA polymerase iii, delta' subunit TD68_10180 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 TD68_10185 ENOG4108UK2 deaminase TD68_10190 ENOG4105KQC Competence protein TD68_10200 ENOG4108D32 Methyltransferase TD68_10210 ENOG4108WF2 Metal Dependent Phosphohydrolase TD68_10215 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) TD68_10220 ENOG410812S Rna-binding protein TD68_10225 ENOG4105E2X shikimate dehydrogenase TD68_10230 ENOG4105CQW ribosome biogenesis GTPase YqeH TD68_10235 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase TD68_10260 ENOG41080BT SNARE associated Golgi TD68_10265 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TD68_10285 ENOG41067XF inhibitor TD68_10305 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family TD68_10325 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) TD68_10340 ENOG4105WDR TD68_10345 ENOG4107RSM transcriptional regulator TD68_10350 ENOG4105D94 Major Facilitator Superfamily TD68_10355 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) TD68_10360 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) TD68_10365 ENOG41082JN Transcriptional regulator TD68_10375 ENOG4105TMB Formate nitrite transporter TD68_10380 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) TD68_10385 ENOG4108JB9 formate dehydrogenase TD68_10400 ENOG4105C28 cystathionine TD68_10415 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) TD68_10430 ENOG4107XRG penicillin-binding protein TD68_10435 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) TD68_10440 ENOG4105DBI uridine monophosphokinase TD68_10445 ENOG4105CFP Peptidase U32 TD68_10450 ENOG4105XYU peptidase (U32 family) TD68_10455 ENOG4108VQJ O-methyltransferase TD68_10460 ENOG4105HHA aminodeoxychorismate lyase TD68_10465 ENOG4105VPH UPF0473 protein TD68_10470 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) TD68_10475 ENOG4105VBH UPF0297 protein TD68_10480 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) TD68_10485 ENOG4105C02 permease TD68_10490 ENOG4105CDA abc transporter atp-binding protein TD68_10495 ENOG4105CT1 (ABC) transporter TD68_10500 ENOG4105EAD ABC transporter TD68_10505 ENOG4105DRP amino acid AbC transporter TD68_10510 ENOG41060CR TD68_10520 ENOG4105C7H Helicase, RecD TraA family TD68_10530 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) TD68_10535 ENOG4105C3J Cysteine desulfurase TD68_10545 ENOG4105D1H recombination factor protein RarA TD68_10550 ENOG4105CUZ uba thif-type nad fad binding protein TD68_10555 ENOG4105C9M aspartyl-trna synthetase TD68_10560 ENOG4105CUT histidyl-tRNA synthetase TD68_10565 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase TD68_10570 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) TD68_10575 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) TD68_10585 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) TD68_10590 ENOG41067VP Protein of unknown function (DUF1049) TD68_10595 ENOG4105NCW Trka-c domain protein TD68_10600 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) TD68_10610 ENOG4105CKP Polysaccharide Biosynthesis Protein TD68_10615 ENOG4108QG2 Membrane TD68_10620 ENOG4105NAP TD68_10625 ENOG4105VIE preprotein translocase, subunit YajC TD68_10630 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) TD68_10635 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) TD68_10640 ENOG41061AI Protein of unknown function (DUF2905) TD68_10645 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) TD68_10650 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) TD68_10660 ENOG4105IE8 Alpha-ketoglutarate permease TD68_10675 ENOG4105BZG amino acid carrier protein TD68_10680 ENOG4105CDY transcriptional regulatory protein TD68_10695 ENOG410901P UPF0249 protein TD68_10700 ENOG4108X79 transcriptional regulator TD68_10705 ENOG4105F8D glycoside hydrolase family 4 TD68_10710 ENOG4105CK1 PTS System TD68_10715 ENOG4105VCP PTS System TD68_10720 ENOG4105VZJ PTS System TD68_10730 ENOG4106678 morphogenetic protein associated with SpoVID TD68_10735 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) TD68_10740 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase TD68_10745 ENOG4108IYU L-aspartate oxidase TD68_10760 ENOG4105CQC Prephenate dehydratase TD68_10765 ENOG41090I5 UPF0735 ACT domain-containing protein TD68_10770 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control TD68_10780 ENOG4105K46 50S ribosomal protein l27 TD68_10785 ENOG4105X36 (ribosomal) protein TD68_10790 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) TD68_10805 ENOG4107QMS site-determining protein TD68_10810 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) TD68_10815 ENOG4105YHC Rod shape-determining protein MreD TD68_10820 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) TD68_10825 ENOG4105DFF Rod shape-determining protein mreb TD68_10830 ENOG4105W5Q DNA repair protein (RadC TD68_10835 ENOG4108Z03 MAF-like protein TD68_10845 ENOG4106A3R peptidase TD68_10850 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase TD68_10855 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) TD68_10865 ENOG4106AR7 Spore coat protein TD68_10870 ENOG41068KH stage VI sporulation protein D TD68_10870 ENOG41068KH stage VI sporulation protein D TD68_10875 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase TD68_10880 ENOG4105D52 delta-aminolevulinic acid dehydratase TD68_10890 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) TD68_10900 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) TD68_10910 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) TD68_10915 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) TD68_10920 ENOG4108IUQ atp-dependent protease TD68_10925 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) TD68_10930 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation TD68_10940 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) TD68_10945 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) TD68_10950 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) TD68_10955 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) TD68_10960 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase TD68_10965 ENOG4108ZP8 Acetolactate synthase small subunit TD68_10970 ENOG4105C7K acetolactate synthase TD68_10975 ENOG4105I4A GCN5-related N-acetyltransferase TD68_10980 ENOG4107KM7 Heat induced stress protein YflT TD68_10990 ENOG4105M59 Phosphodiesterase, mj0936 family TD68_10995 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) TD68_11000 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) TD68_11005 ENOG4108XJQ germination protein TD68_11010 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) TD68_11015 ENOG41067TZ transcriptional regulator, MarR family TD68_11020 ENOG4105PFC Transcriptional regulator TD68_11030 ENOG4105E33 succinate dehydrogenase TD68_11040 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit TD68_11050 ENOG4105CFH Aspartokinase TD68_11055 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) TD68_11060 ENOG4105K63 Thioredoxin TD68_11065 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) TD68_11070 ENOG4105C10 Electron transfer flavoprotein TD68_11075 ENOG4105BZJ Electron transfer flavoprotein TD68_11080 ENOG41060WC Enoyl-CoA hydratase TD68_11085 ENOG4107Z3H Transcriptional regulator, TetR family TD68_11090 ENOG4105CEY Amp-dependent synthetase and ligase TD68_11100 ENOG4105C98 muts2 protein TD68_11105 ENOG4105DCG PHP domain protein TD68_11120 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) TD68_11125 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) TD68_11130 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) TD68_11135 ENOG4108RWN rrna methyltransferase TD68_11140 ENOG41067MF small acid-soluble spore protein TD68_11150 ENOG4105CQB FAD linked oxidase domain protein TD68_11155 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) TD68_11170 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) TD68_11175 ENOG4105DRS transport system, permease TD68_11190 ENOG4108MDK Dehydrogenase TD68_11200 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase TD68_11205 ENOG4105EF1 ribulokinase TD68_11225 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) TD68_11235 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase TD68_11240 ENOG4105CN9 Peptidase m42 family protein TD68_11250 ENOG410696E Membrane TD68_11255 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) TD68_11260 ENOG4105VJV 50s ribosomal protein L35 TD68_11265 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) TD68_11280 ENOG41067MG lrgb family TD68_11290 ENOG4105DY9 regulatoR TD68_11295 ENOG4108HRK Histidine kinase TD68_11300 ENOG4105U0R haloacid dehalogenase-like hydrolase TD68_11305 ENOG4105C22 threonyL-tRNA synthetase TD68_11310 ENOG4108TDW sporulation protein YtxC TD68_11330 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) TD68_11335 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) TD68_11340 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase TD68_11345 ENOG4105KVH Transcriptional regulator TD68_11350 ENOG4105F27 Major Facilitator TD68_11355 ENOG4105CV8 reductase TD68_11360 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) TD68_11370 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) TD68_11375 ENOG4105C2M dna polymerase I TD68_11380 ENOG4105BZU Histidine kinase TD68_11385 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TD68_11395 ENOG4108HMX isocitrate dehydrogenase (NADP) TD68_11400 ENOG4105BZN citrate synthase TD68_11410 ENOG4108REF Sporulation integral membrane protein ytvi TD68_11415 ENOG4105FS0 cytoplasmic membrane protein TD68_11420 ENOG4105CA9 Pyruvate kinase TD68_11425 ENOG4105CTQ phosphohexokinase TD68_11435 ENOG4108IEY Carboxyl transferase domain TD68_11440 ENOG4105C6K Malic enzyme TD68_11445 ENOG4105C0B DNA polymerase III (alpha subunit) TD68_11450 ENOG4105VV2 TD68_11460 ENOG4106EVM TD68_11465 ENOG4105SFS phosphoesterase RecJ domain protein TD68_11480 ENOG4105E8R UPF0173 metal-dependent hydrolase TD68_11490 ENOG4105CH7 arginosuccinase TD68_11495 ENOG4105CDH Citrulline--aspartate ligase TD68_11500 ENOG4105EPU Molybdenum cofactor synthesis domain protein TD68_11505 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) TD68_11515 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) TD68_11520 ENOG4105KBJ sporulation protein ytfj TD68_11530 ENOG4105VK3 rdd domain containing protein TD68_11535 ENOG4105D07 Signal peptide peptidase, SppA TD68_11540 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) TD68_11545 ENOG4105EFZ amidohydrolase TD68_11550 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) TD68_11585 ENOG4105U5Y Transcriptional regulator TD68_11595 ENOG4105BZU Histidine kinase TD68_11600 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) TD68_11620 ENOG4105CHJ isochorismatase hydrolase TD68_11635 ENOG41090MY MarR family Transcriptional regulator TD68_11640 ENOG4108VGI doxx family TD68_11645 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase TD68_11650 ENOG4105FBA Phospholipase Carboxylesterase TD68_11665 ENOG4105EGI Transcriptional regulator TD68_11670 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) TD68_11680 ENOG4105F1V Acetoin utilization protein TD68_11685 ENOG4105W87 Cbs domain TD68_11690 ENOG4105DGU Histone deacetylase TD68_11695 ENOG4105ER2 Ompa motb domain protein TD68_11700 ENOG4107R0U MotA TolQ exbB proton channel TD68_11705 ENOG4105ETE Transcriptional regulator (LacI family TD68_11710 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase TD68_11730 ENOG4105DFU Cell wall formation (By similarity) TD68_11740 ENOG4108VDD TRNA binding domain protein TD68_11755 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ TD68_11770 ENOG4105C6K Malic enzyme TD68_11775 ENOG4105C8F Beta-lactamase domain protein TD68_11780 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) TD68_11790 ENOG4108V15 phosphotransferase enzyme family TD68_11795 ENOG4108IUM Glycogen debranching enzyme TD68_11810 ENOG4107F58 2'-5' rna ligase TD68_11815 ENOG4105C6T cysteine synthase TD68_11820 ENOG4107QSE Dipeptidase TD68_11825 ENOG4105C7N Xanthine uracil vitamin C permease TD68_11830 ENOG4105YW5 deoR family transcriptional regulator TD68_11845 ENOG4105CBX hi0933 family TD68_11850 ENOG4105C94 Transporter TD68_11860 ENOG4105MU9 integral membrane protein TD68_11865 ENOG4105DDC Oxidoreductase domain protein TD68_11875 ENOG4105F5H Glycosyl Hydrolase Family 88 TD68_11895 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component TD68_11905 ENOG4106A3M Cytochrome p-450 TD68_11910 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) TD68_11920 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) TD68_11925 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) TD68_11930 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) TD68_11935 ENOG4105NTD Inherit from COG: Hydrolase TD68_11940 ENOG41085GJ domain protein TD68_11945 ENOG4105C8T Leucyl-tRNA synthetase TD68_11955 ENOG4105BZU Histidine kinase TD68_11960 ENOG410605W Major Facilitator TD68_11965 ENOG4106UBQ TD68_11975 ENOG4105C19 ABC transporter TD68_11980 ENOG4105EWM Histidine kinase TD68_11990 ENOG4107R34 abc transporter permease protein TD68_11995 ENOG4105C19 ABC transporter TD68_12010 ENOG4105DVE abc transporter atp-binding protein TD68_12015 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family TD68_12035 ENOG4105N5T Radical SAM Protein TD68_12050 ENOG4105E8V Alpha Beta Hydrolase Fold protein TD68_12055 ENOG4108Z0R Transferase TD68_12060 ENOG4105C85 amino acid TD68_12065 ENOG4105CAQ asparagine synthetase TD68_12070 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP TD68_12075 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase TD68_12090 ENOG4105D2X ABC transporter substrate-binding protein TD68_12100 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component TD68_12120 ENOG4108RMU ferritin dps family protein TD68_12135 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) TD68_12140 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) TD68_12145 ENOG4108V2W Carbonate dehydratase TD68_12150 ENOG4105CKI cobalamin synthesis protein TD68_12155 ENOG4105NRA 50s ribosomal protein l31 type b TD68_12170 ENOG4108YQE rare lipoprotein a TD68_12175 ENOG4105CC5 ABC transporter TD68_12180 ENOG4105CC5 ABC transporter TD68_12185 ENOG4105DIK (ABC) transporter TD68_12190 ENOG4105DSE periplasmic solute binding protein TD68_12195 ENOG4105DTQ mandelate racemase muconate lactonizing TD68_12200 ENOG4105CEY Amp-dependent synthetase and ligase TD68_12205 ENOG4108IPT Naphthoate synthase TD68_12210 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) TD68_12215 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) TD68_12220 ENOG4105E4F Isochorismate synthase TD68_12235 ENOG4108IAJ Nad-dependent epimerase dehydratase TD68_12240 ENOG4107SBE Glycosyl transferase (Group 1 TD68_12265 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) TD68_12275 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) TD68_12405 ENOG4105N67 Proton-coupled thiamine transporter YuaJ TD68_12425 ENOG4105DZ6 Band 7 protein TD68_12435 ENOG4106DF1 TD68_12440 ENOG4108VNY MOSC domain protein TD68_12445 ENOG4108JB8 alcohol dehydrogenase TD68_12450 ENOG4105C26 Dehydrogenase TD68_12455 ENOG4105TRT Transcriptional regulator TD68_12470 ENOG4105CZN Potassium uptake protein TD68_12475 ENOG4107I77 yiaA/B two helix domain TD68_12480 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj TD68_12495 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) TD68_12505 ENOG4105EE0 oxidoreductase TD68_12510 ENOG4108Z0Z intracellular protease Pfpi family TD68_12515 ENOG4105DKG l-rhamnose isomerase TD68_12520 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) TD68_12525 ENOG4105DET Rhamnulokinase TD68_12530 ENOG4105E98 transcriptional regulator DeoR family TD68_12540 ENOG4105C8Q Methyl-accepting chemotaxis TD68_12545 ENOG4105C8Q Methyl-accepting chemotaxis TD68_12550 ENOG4105C8Q Methyl-accepting chemotaxis TD68_12555 ENOG4105C8Q Methyl-accepting chemotaxis TD68_12570 ENOG4105EA8 2-Nitropropane dioxygenase TD68_12575 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme TD68_12585 ENOG4105C37 (CBS) domain TD68_12600 ENOG4107PBV potassium channel TD68_12605 ENOG4107PBV potassium channel TD68_12620 ENOG4107QYV phosphohexose isomerase TD68_12630 ENOG4107QW4 alcohol dehydrogenase TD68_12635 ENOG4105WG9 Conserved Protein TD68_12645 ENOG4105CHM Aminotransferase TD68_12650 ENOG4108ZB6 transcriptional regulator AsnC family TD68_12655 ENOG4108MUZ hydrolase TD68_12665 ENOG4105C87 Aminotransferase class I and II TD68_12670 ENOG4108HGU Histidine kinase TD68_12675 ENOG4105Y38 Kinase-associated protein B TD68_12695 ENOG4105BZ4 penicillin-binding protein TD68_12700 ENOG4105KIR Thiol-disulfide oxidoreductase dcc TD68_12715 ENOG4108MRH transcriptional regulatory protein TD68_12720 ENOG4105DIH basic membrane TD68_12725 ENOG4108JQ9 ABC transporter TD68_12730 ENOG4105UIB (ABC) transporter TD68_12750 ENOG4105D65 subunit l TD68_12755 ENOG4105HC0 Na H antiporter TD68_12760 ENOG4108ZE9 Monovalent cation H antiporter subunit C TD68_12765 ENOG4108JPZ Monovalent cation H antiporter subunit D TD68_12770 ENOG4105SC1 monovalent cation H antiporter subunit E TD68_12780 ENOG4105KJM monovalent cation h antiporter subunit g TD68_12785 ENOG4105KA0 thioesterase Superfamily protein TD68_12795 ENOG4105BZU Histidine kinase TD68_12820 ENOG4105D58 Diguanylate phosphodiesterase TD68_12825 ENOG4105DAP Nicotinate phosphoribosyltransferase TD68_12850 ENOG4105C02 permease TD68_12865 ENOG410904N short-chain dehydrogenase reductase TD68_12880 ENOG4108K8K Transcriptional regulator TD68_12885 ENOG4105DCF alanine dehydrogenase TD68_12895 ENOG4105WQT MbtH domain protein TD68_12900 ENOG4105CEY Amp-dependent synthetase and ligase TD68_12905 ENOG4105WQI isochorismatase TD68_12910 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase TD68_12915 ENOG4105E4F Isochorismate synthase TD68_12920 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase TD68_12925 ENOG4105NIV Esterase TD68_12955 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) TD68_12965 ENOG41069ER domain protein TD68_12975 ENOG4105CEP NADH dehydrogenase TD68_12990 ENOG4108YX9 iron--sulfur cluster insertion protein erpA TD68_13005 ENOG4105ZKE UPF0349 protein TD68_13015 ENOG4105PY6 Phenolic acid decarboxylase TD68_13025 ENOG41083MR nifu domain-containing protein TD68_13030 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein TD68_13035 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) TD68_13040 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) TD68_13045 ENOG4105D6E homoserine dehydrogenase TD68_13055 ENOG4108W5N phosphatidylglycerophosphatase a TD68_13060 ENOG4105D4U had-superfamily hydrolase, subfamily iia TD68_13070 ENOG4105MMD transcriptional regulator TD68_13075 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) TD68_13080 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) TD68_13085 ENOG4105FAA peptidase M23 TD68_13090 ENOG4108YTE sporulation protein YunB TD68_13095 ENOG4105KZD Domain of unknown function (DUF1805) TD68_13100 ENOG4107R8B 5'-nucleotidase TD68_13110 ENOG4105I3N Conserved Protein TD68_13125 ENOG4105CD3 dihydroorotase TD68_13130 ENOG4105G9B Transcriptional regulator TD68_13140 ENOG4105EMN RNA polymerase sigma factor TD68_13195 ENOG4105CJ1 ABC, transporter TD68_13205 ENOG4107YV9 domain protein TD68_13220 ENOG4105XRQ Xanthine dehydrogenase accessory factor TD68_13230 ENOG4105C5R Aminotransferase TD68_13240 ENOG4108I0Q anthranilate phosphoribosyltransferase TD68_13245 ENOG4108K8S endonuclease I TD68_13255 ENOG4108IJ9 (ABC) transporter TD68_13260 ENOG4105FDP GntR family transcriptional regulator TD68_13265 ENOG4108KPW sugar kinase TD68_13270 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component TD68_13275 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component TD68_13280 ENOG4105XN3 extracellular solute-binding protein family 1 TD68_13285 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine TD68_13290 ENOG4105PKS Excinuclease abc c subunit domain protein TD68_13295 ENOG4107VFR oxidoreductase TD68_13300 ENOG4105DIW FeS assembly protein SUFB TD68_13305 ENOG4108UNV SUF system FeS assembly protein, NifU family TD68_13310 ENOG4105C9B Cysteine desulfurase TD68_13315 ENOG4105JRK feS assembly protein SufD TD68_13320 ENOG4105C3K feS assembly ATPase SufC TD68_13330 ENOG4105D01 (LipO)protein TD68_13335 ENOG4108UMI ABC transporter, permease TD68_13340 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) TD68_13365 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) TD68_13370 ENOG41080E8 Transcriptional regulator, Spx MgsR family TD68_13375 ENOG4105C1G acyl-Coa dehydrogenase TD68_13380 ENOG4105CHU acetyl-coa acetyltransferase TD68_13405 ENOG41067TZ transcriptional regulator, MarR family TD68_13410 ENOG4105C0R drug resistance transporter emrb qaca subfamily TD68_13420 ENOG4105E0A ABC, transporter TD68_13435 ENOG4105E1F short-chain dehydrogenase reductase TD68_13440 ENOG4105HUF DNA protection during starvation protein TD68_13445 ENOG4105C0H protease TD68_13455 ENOG4105F3H Histidine kinase TD68_13460 ENOG41067SE Tetr family transcriptional regulator TD68_13465 ENOG4105C9Q fumarate hydratase class II TD68_13490 ENOG4105WH1 Two component transcriptional regulator luxr family TD68_13495 ENOG4105ENE Histidine kinase TD68_13510 ENOG41087YS Phage shock protein A TD68_13525 ENOG4108WBT adenosyltransferase TD68_13530 ENOG4105E0A ABC, transporter TD68_13535 ENOG4105EHG Permease protein TD68_13540 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) TD68_13545 ENOG4105EWI Short-chain dehydrogenase reductase Sdr TD68_13550 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein TD68_13560 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TD68_13570 ENOG4106DF4 Sigma-70, region 4 TD68_13575 ENOG4105F0F Oxalate decarboxylase TD68_13585 ENOG4107RBB ABC transporter, permease TD68_13590 ENOG4105C19 ABC transporter TD68_13595 ENOG4108WMK Efflux transporter RND family MFP subunit TD68_13600 ENOG4105E0A ABC, transporter TD68_13605 ENOG4105EHG Permease protein TD68_13610 ENOG4105DQ5 transport system permease protein TD68_13620 ENOG4105D5Q Arginine ornithine antiporter TD68_13635 ENOG4107K5X Membrane-bound metal-dependent hydrolase TD68_13640 ENOG4107QZ2 Sulfatase TD68_13645 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family TD68_13650 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein TD68_13655 ENOG4105E0C molybdate abc transporter TD68_13675 ENOG4105EEQ Na H antiporter TD68_13685 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) TD68_13690 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) TD68_13695 ENOG4105EEM helicase TD68_13700 ENOG4105EN6 Membrane TD68_13715 ENOG4107ZQN disulfide bond TD68_13720 ENOG4105C59 p-type ATPase TD68_13725 ENOG4105C59 p-type ATPase TD68_13730 ENOG410681U heavy metal transport detoxification protein TD68_13735 ENOG4105VPX protein, conserved in bacteria TD68_13740 ENOG4105D9R oxidoreductase TD68_13745 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) TD68_13750 ENOG4105ME7 Membrane TD68_13755 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes TD68_13760 ENOG4105RXJ TD68_13765 ENOG4105KPY Small multidrug resistance protein TD68_13770 ENOG4105KBX Transcriptional regulator, TetR family TD68_13780 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) TD68_13785 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) TD68_13795 ENOG4105XZU Preprotein translocase, subunit SecG TD68_13815 ENOG4105KVH Transcriptional regulator TD68_13820 ENOG4105C8Q Methyl-accepting chemotaxis TD68_13825 ENOG4105R40 Glycine betaine carnitine choline TD68_13830 ENOG4108HQR Glycine betaine TD68_13835 ENOG4105E90 ABC transporter TD68_13840 ENOG4108IJ8 ABC transporter TD68_13845 ENOG4107HG4 Transcriptional regulator TD68_13850 ENOG4105R40 Glycine betaine carnitine choline TD68_13855 ENOG4108HQR Glycine betaine TD68_13860 ENOG4105E90 ABC transporter TD68_13865 ENOG4108IJ8 ABC transporter TD68_13870 ENOG4107HG4 Transcriptional regulator TD68_13875 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein TD68_13885 ENOG4105T65 Membrane-associated protein TD68_13890 ENOG4108W0I acetyltransferase TD68_13905 ENOG4105FJR Lmbe family TD68_13920 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase TD68_13925 ENOG4108IAJ Nad-dependent epimerase dehydratase TD68_13930 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase TD68_13935 ENOG4107QQG Dehydrogenase TD68_13940 ENOG4105IIU Aminopeptidase TD68_13945 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) TD68_13950 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) TD68_13955 ENOG4105CP7 Triose-phosphate isomerase TD68_13960 ENOG4105BZA Phosphoglycerate kinase TD68_13965 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase TD68_13980 ENOG4105CMD Transcriptional regulator, GntR family TD68_13985 ENOG4105DEN Luciferase family TD68_13990 ENOG4105GZI Transcriptional regulator TD68_13995 ENOG4107RT3 EamA-like transporter family TD68_14005 ENOG4105VRS hydrolase family 18 TD68_14010 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) TD68_14015 ENOG4107QR9 Iron-sulfur cluster binding protein TD68_14020 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) TD68_14025 ENOG4105JXH GntR family transcriptional regulator TD68_14030 ENOG4105DAA L-lactate TD68_14035 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TD68_14045 ENOG4108ZPC Polysaccharide pyruvyl transferase TD68_14050 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase TD68_14055 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family TD68_14060 ENOG4105D3Q Sugar transferase TD68_14070 ENOG4105K64 Glycosyl transferase, family 2 TD68_14080 ENOG4107QRS glycosyltransferase group 2 family protein TD68_14085 ENOG41068W6 Capsular polysaccharide biosynthesis protein TD68_14090 ENOG4108KMV Glycosyl transferase (Group 1 TD68_14095 ENOG4105K64 Glycosyl transferase, family 2 TD68_14100 ENOG4108PQP glycosyl transferase group 1 TD68_14110 ENOG4108QV3 biosynthesis protein TD68_14115 ENOG4105HTX biosynthesis protein TD68_14140 ENOG4105CJ1 ABC, transporter TD68_14160 ENOG4105DWV Homoserine O-trans-acetylase TD68_14165 ENOG4107V2S Transcriptional regulator TD68_14170 ENOG4105EDQ levansucrase EC 2.4.1.10 TD68_14175 ENOG4108HKT sucrose-6-phosphate hydrolase TD68_14180 ENOG4107QTZ amino acid TD68_14200 ENOG4108MK9 spermidine N(1)-acetyltransferase TD68_14215 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) TD68_14225 ENOG4108URH decarboxylase TD68_14230 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain TD68_14235 ENOG4105CHH sulfate transporter TD68_14240 ENOG4108V2W Carbonate dehydratase TD68_14245 ENOG4105C5I Dehydrogenase TD68_14255 ENOG4105C19 ABC transporter TD68_14260 ENOG4105EWM Histidine kinase TD68_14270 ENOG4105GGE ribonuclease TD68_14275 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase TD68_14280 ENOG4105KRI phosphocarrier protein (HPr TD68_14285 ENOG4105CIE May be required for sporulation (By similarity) TD68_14290 ENOG4105CHW UPF0052 protein TD68_14295 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) TD68_14300 ENOG4108Z4K mutator MutT protein TD68_14305 ENOG4105C3M thioredoxin reductase TD68_14320 ENOG4105BZ1 (ABC) transporter TD68_14330 ENOG4105VRR gCN5-related N-acetyltransferase TD68_14335 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase TD68_14340 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) TD68_14345 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase TD68_14350 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) TD68_14355 ENOG4105ECC imidazole-glycerol-phosphate dehydratase TD68_14360 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) TD68_14365 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) TD68_14370 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) TD68_14380 ENOG4108E16 pectate lyase TD68_14385 ENOG4108S4C acetyltransferase TD68_14390 ENOG4107XGZ Hydrolase TD68_14395 ENOG4105HKU nucleoside recognition domain-containing protein TD68_14400 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) TD68_14405 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) TD68_14410 ENOG4105CE4 GlcNAc 6-P deacetylase TD68_14415 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) TD68_14420 ENOG4105FDP GntR family transcriptional regulator TD68_14425 ENOG41088CQ domain protein TD68_14430 ENOG41086DT Membrane protein of unknown function TD68_14435 ENOG41067S9 phage shock protein C, PspC TD68_14440 ENOG4108PY7 TD68_14455 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) TD68_14460 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) TD68_14475 ENOG4105MKU Transcriptional regulator TD68_14505 ENOG4105CN1 protease TD68_14510 ENOG4105CRP Part of the ABC transporter FtsEX involved in TD68_14515 ENOG4105CAK Cell division ATP-binding protein ftsE TD68_14530 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) TD68_14540 ENOG4105MS2 ribosomal subunit Interface protein TD68_14555 ENOG4105MQ3 flagellar protein FliS TD68_14560 ENOG4107RT6 flagellar hook-associated TD68_14565 ENOG41083S7 flagellar protein FlaG TD68_14570 ENOG4105I03 Flagellin TD68_14575 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) TD68_14580 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) TD68_14585 ENOG4105MKD TD68_14590 ENOG4105DTJ flagellar hook-associated protein TD68_14595 ENOG4105E1Q flagellar hook-associated protein TD68_14610 ENOG4105RU3 TD68_14615 ENOG41081UC Inherit from COG: Competence protein TD68_14635 ENOG4105WH1 Two component transcriptional regulator luxr family TD68_14640 ENOG4105BZU Histidine kinase TD68_14645 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein TD68_14650 ENOG4108KGH TRANSCRIPTIONal TD68_14655 ENOG4105ESV Glycosyl transferase, family 4 TD68_14660 ENOG4107EF8 Glycosyl transferase (Group 1 TD68_14675 ENOG4105QZI O-Antigen Polymerase TD68_14680 ENOG4105C6Y Udp-glucose 6-dehydrogenase TD68_14685 ENOG4107RA4 Glycosyl transferase (Group 1 TD68_14690 ENOG4105PSV Polysaccharide Biosynthesis Protein TD68_14695 ENOG4105D3Q Sugar transferase TD68_14705 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase TD68_14710 ENOG4105JFG SpoIID LytB domain protein TD68_14725 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase TD68_14730 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase TD68_14735 ENOG4105EY8 ABC transporter TD68_14745 ENOG4107SJB teichoic acid biosynthesis TD68_14750 ENOG4107SJB teichoic acid biosynthesis TD68_14755 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase TD68_14765 ENOG4107RZX Teichoic acid biosynthesis protein TD68_14775 ENOG4105DG6 mannose-6-phosphate isomerase TD68_14790 ENOG4108NHD germination protein TD68_14795 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) TD68_14800 ENOG4105C54 Major Facilitator superfamily TD68_14805 ENOG4108KGH TRANSCRIPTIONal TD68_14810 ENOG4105J7I hydrolase TD68_14815 ENOG4105K4H Nlp p60 protein TD68_14820 ENOG4105PNM synthesis protein TD68_14830 ENOG4105N98 Capsule biosynthesis protein capB TD68_14840 ENOG4108Q8B Spore germination protein TD68_14850 ENOG4105ETE Transcriptional regulator (LacI family TD68_14855 ENOG4108RVA ribokinase TD68_14860 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) TD68_14865 ENOG4105C2J ABC transporter TD68_14870 ENOG4105CNN ABC, transporter TD68_14875 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator TD68_14890 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein TD68_14895 ENOG4107FQX Alpha-acetolactate decarboxylase TD68_14905 ENOG4107RSM transcriptional regulator TD68_14920 ENOG4107XC4 flavin reductase domain protein, FMN-binding TD68_14925 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia TD68_14940 ENOG4105UP7 3-epimerase TD68_14950 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) TD68_14960 ENOG4105CAH Chromate TD68_14965 ENOG4105FGV Chromate TD68_14975 ENOG4108WS4 fmn reductase TD68_14980 ENOG4107V2S Transcriptional regulator TD68_15025 ENOG4105C6Y Udp-glucose 6-dehydrogenase TD68_15030 ENOG4108RB3 Capsular polysaccharide biosynthesis protein TD68_15035 ENOG4107YJ4 chain length determinant protein TD68_15040 ENOG4105HTX biosynthesis protein TD68_15045 ENOG4105KBK Zinc finger, swim domain protein TD68_15050 ENOG4105C0D helicase TD68_15055 ENOG410667J hydrolase TD68_15060 ENOG4105E98 transcriptional regulator DeoR family TD68_15065 ENOG4105Z8H single-stranded DNA-binding protein TD68_15080 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) TD68_15085 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) TD68_15095 ENOG4105CGA flagellar basal-body rod protein FlgG TD68_15105 ENOG4105DFF Rod shape-determining protein mreb TD68_15110 ENOG4105MT0 Sporulation transcriptional regulator spoiiid TD68_15115 ENOG4107MII Sugar-specific transcriptional regulator TrmB TD68_15120 ENOG4105CZM Major Facilitator TD68_15125 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease TD68_15130 ENOG41080V3 Major Facilitator superfamily TD68_15135 ENOG4105D3W isochorismatase TD68_15140 ENOG4107P26 TD68_15145 ENOG4105BZU Histidine kinase TD68_15155 ENOG4105CNI cell division protein FtsW TD68_15160 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase TD68_15170 ENOG4105FRN stage II sporulation protein TD68_15175 ENOG4107TCE N-acetyltransferase TD68_15185 ENOG4105C5E polysaccharide biosynthesis protein TD68_15190 ENOG4105C1B dTDP-glucose 4-6-dehydratase TD68_15195 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase TD68_15200 ENOG4107TY6 Acylneuraminate cytidylyltransferase TD68_15225 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) TD68_15230 ENOG4107TXC Transcriptional regulator TD68_15235 ENOG4106BRK TD68_15240 ENOG4108RYK Nad-dependent epimerase dehydratase TD68_15250 ENOG4105CQM Urea amidohydrolase subunit alpha TD68_15255 ENOG4105KI2 Urea amidohydrolase subunit beta TD68_15260 ENOG4108YZ9 Urea amidohydrolase subunit gamma TD68_15280 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) TD68_15285 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) TD68_15290 ENOG4108TF4 von Willebrand factor, type A TD68_15305 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) TD68_15315 ENOG4106778 Protein of unknown function (DUF1146) TD68_15325 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) TD68_15330 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) TD68_15335 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) TD68_15340 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) TD68_15360 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) TD68_15370 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) TD68_15375 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) TD68_15380 ENOG4108UIC UPF0340 protein TD68_15385 ENOG4108YZG isomerase TD68_15390 ENOG4107WAU Protein tyrosine phosphatase TD68_15395 ENOG410815N Probably functions as a manganese efflux pump (By similarity) TD68_15400 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) TD68_15410 ENOG4108ZXQ stage ii sporulation protein r TD68_15425 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) TD68_15430 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) TD68_15435 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase TD68_15445 ENOG4107TT2 Auxin Efflux Carrier TD68_15450 ENOG4105C6K Malic enzyme TD68_15455 ENOG4107104 thymidine kinase TD68_15460 ENOG41082DI 50s ribosomal protein l31 TD68_15465 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) TD68_15470 ENOG4105CBT Fructose-1,6-bisphosphatase TD68_15475 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) TD68_15485 ENOG4105D2N Aldolase TD68_15490 ENOG410812K response regulator receiver protein TD68_15500 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) TD68_15510 ENOG4105C1G acyl-Coa dehydrogenase TD68_15515 ENOG4105DF6 Fe-S oxidoreductase TD68_15525 ENOG4105E5J UV damage endonuclease TD68_15535 ENOG4105NAE bifunctional deaminase-reductase domain protein TD68_15540 ENOG4105BZ1 (ABC) transporter TD68_15545 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) TD68_15555 ENOG4105R3A Nitrate reductase TD68_15560 ENOG4108IUE nitrate reductase beta subunit TD68_15580 ENOG4107V6Q Cyclic nucleotide-binding domain TD68_15590 ENOG4105C75 arginyL-tRNA synthetase TD68_15595 ENOG410684U Domain of unknown function (DUF1934) TD68_15605 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E TD68_15650 ENOG41090UD (LipO)protein TD68_15655 ENOG4107JM4 Tetratricopeptide repeat TD68_15665 ENOG4108UIN ybak prolyl-trna synthetase associated region TD68_15670 ENOG4105CYW agmatinase TD68_15675 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) TD68_15680 ENOG4105BZ4 penicillin-binding protein TD68_15685 ENOG4108XFG YwhD family TD68_15690 ENOG4108Z4T Peptidase M50 TD68_15695 ENOG41069HH 4-oxalocrotonate tautomerase TD68_15700 ENOG41067TZ transcriptional regulator, MarR family TD68_15705 ENOG4105CUB amino acid TD68_15715 ENOG4105DCI Phosphohydrolase TD68_15725 ENOG4108VCI transcription factor, rsfa family TD68_15730 ENOG4108RNG Permease of the drug metabolite transporter TD68_15735 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) TD68_15740 ENOG4105DUM transcriptional regulator, lysR family TD68_15745 ENOG4105HMI Membrane TD68_15750 ENOG4108IJ2 phosphate acetyltransferase TD68_15760 ENOG4105FCW Major Facilitator superfamily TD68_15765 ENOG4105C2C drug resistance transporter, Bcr CflA TD68_15775 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase TD68_15780 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase TD68_15785 ENOG4105C1B dTDP-glucose 4-6-dehydratase TD68_15790 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) TD68_15795 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD TD68_15830 ENOG4105C26 Dehydrogenase TD68_15835 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) TD68_15840 ENOG4108RJ9 Glycosyl transferase, family 2 TD68_15855 ENOG4105DWF phosphomethylpyrimidine kinase TD68_15865 ENOG4108UW5 maltose o-acetyltransferase TD68_15875 ENOG4105C5Y PTS System TD68_15880 ENOG4108QTI )-transporter TD68_15895 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin TD68_15905 ENOG4105DEN Luciferase family TD68_15910 ENOG4108DBC nitroreductase TD68_15930 ENOG41060D1 Quinol oxidase TD68_15940 ENOG4105BZ9 Cytochrome C oxidase, subunit I TD68_15945 ENOG4105E2S oxidase) subunit II TD68_15950 ENOG4107BMA Transglycosylase associated protein TD68_15960 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) TD68_15965 ENOG4105WH5 Teichoic acid glycosylation protein TD68_16000 ENOG4107ZXU DSBA oxidoreductase TD68_16005 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) TD68_16015 ENOG4105CMU LysR family (Transcriptional regulator TD68_16020 ENOG4105VAW lrga family TD68_16025 ENOG41067MG lrgb family TD68_16030 ENOG4108RDQ ABC transporter TD68_16050 ENOG41067MG lrgb family TD68_16060 ENOG4105DR4 Methyltransferase TD68_16070 ENOG4105CK1 PTS System TD68_16090 ENOG4105X1N Glycosyl transferase family 8 TD68_16100 ENOG4105IIU Aminopeptidase TD68_16110 ENOG4105GVJ transcriptional regulator TD68_16115 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) TD68_16125 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase TD68_16140 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) TD68_16145 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein TD68_16150 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) TD68_16155 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD TD68_16160 ENOG4105CM2 brancheD-chain amino acid aminotransferase TD68_16165 ENOG4105F8D glycoside hydrolase family 4 TD68_16170 ENOG4105VCP PTS System TD68_16175 ENOG4105CK1 PTS System TD68_16180 ENOG4105VZJ PTS System TD68_16185 ENOG4105EMD TRANSCRIPTIONal TD68_16190 ENOG4108VX5 3-methyladenine DNA glycosylase TD68_16200 ENOG4105CH6 catalase TD68_16215 ENOG4105DA5 (ABC) transporter TD68_16220 ENOG41069JR TD68_16240 ENOG4105ETS cytosine purines uracil thiamine allantoin TD68_16245 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) TD68_16250 ENOG4108JJ8 (ABC) transporter TD68_16255 ENOG4108JJ9 ABC, transporter TD68_16260 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii TD68_16265 ENOG4105C4M (Ubiquinol oxidase) subunit I TD68_16270 ENOG4105D2K citrate carrier protein TD68_16280 ENOG4107BJW polysaccharide deacetylase TD68_16300 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) TD68_16310 ENOG4105CMR udp-glucose 4-epimerase TD68_16320 ENOG4105BZU Histidine kinase TD68_16325 ENOG4105WH1 Two component transcriptional regulator luxr family TD68_16330 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) TD68_16345 ENOG4107JM4 Tetratricopeptide repeat TD68_16350 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) TD68_16360 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) TD68_16405 ENOG4108JUB Transcriptional regulator TD68_16410 ENOG4105DTD Dehydrogenase TD68_16415 ENOG4108IIH CoA-transferase subunit B TD68_16420 ENOG4105D6N CoA-transferase, subunit a TD68_16425 ENOG4105CY2 Citrate transporter TD68_16430 ENOG4105DHI Methyltransferase TD68_16450 ENOG4105CH6 catalase TD68_16455 ENOG4105D4T Citrate transporter TD68_16465 ENOG4105CID antiterminator TD68_16475 ENOG4105DEU major facilitator superfamily TD68_16480 ENOG4105C1J atp-dependent rna helicase TD68_16490 ENOG4105DDN Pentapeptide repeat-containing protein TD68_16495 ENOG4107TDE lipolytic protein G-D-S-L family TD68_16520 ENOG4108NR7 pectate lyase TD68_16530 ENOG4105H9W Short-chain dehydrogenase reductase Sdr TD68_16550 ENOG4107YZX Universal stress protein TD68_16555 ENOG4105CS2 ec 3.2.1.21 TD68_16560 ENOG4105C5Y PTS System TD68_16565 ENOG4105JKW Valine--pyruvate aminotransferase TD68_16580 ENOG4105CPF Cell wall formation (By similarity) TD68_16595 ENOG4105M6F mutator MutT protein TD68_16600 ENOG4106Z5D Glycoside Hydrolase Family 43 TD68_16610 ENOG4105C84 Histidine ammonia-lyase TD68_16615 ENOG4105CGP Urocanate hydratase TD68_16620 ENOG4105CI2 imidazolone-5-propionate hydrolase TD68_16625 ENOG4107W25 arginase agmatinase formiminoglutamase TD68_16635 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) TD68_16640 ENOG4105D9N nucleoside TD68_16650 ENOG4107RHR regulatoR TD68_16655 ENOG4108TM9 integral membrane protein TD68_16660 ENOG4105ENY Ethanolamine utilization protein eutH TD68_16665 ENOG41066F8 ROK family TD68_16670 ENOG4107QHE Choloylglycine hydrolase TD68_16675 ENOG410667J hydrolase TD68_16730 ENOG4108V5C ABC transporter TD68_16740 ENOG4105WZ4 isomerase TD68_16745 ENOG4105F0H myo-inositol catabolism protein TD68_16750 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) TD68_16760 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) TD68_16765 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) TD68_16770 ENOG4105D7K pfkb domain protein TD68_16780 ENOG4105C26 Dehydrogenase TD68_16790 ENOG4105CPC Aldo Keto reductase TD68_16810 ENOG4107QNK )-transporter TD68_16815 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) TD68_16820 ENOG41061TZ Short-chain dehydrogenase reductase Sdr TD68_16825 ENOG4105ST3 Transcriptional regulator TD68_16830 ENOG4105C26 Dehydrogenase TD68_16840 ENOG41085PJ rdd domain containing protein TD68_16855 ENOG4105J7D transcriptional regulator TD68_16875 ENOG4105BZW Glycerate kinase TD68_16880 ENOG4107QQ0 gntp family TD68_16885 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR TD68_16890 ENOG4105G3Z GntR family transcriptional regulator TD68_16895 ENOG4105CMG Carbohydrate kinase TD68_16900 ENOG4105C6Z Gluconate TD68_16905 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) TD68_16915 ENOG4105D3R alkyl hydroperoxide reductase TD68_16920 ENOG4108JU3 Alkyl hydroperoxide reductase TD68_16930 ENOG4105C85 amino acid TD68_16935 ENOG4106KKU TD68_16940 ENOG4108Z15 abc transporter atp-binding protein TD68_16945 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 TD68_17040 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) TD68_17050 ENOG4105E2A Dehydrogenase TD68_17065 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) TD68_17070 ENOG4105WQG acetyltransferase TD68_17075 ENOG41066UZ arginase EC 3.5.3.1 TD68_17080 ENOG4108IQI permease TD68_17085 ENOG4105C8Y Acetylornithine aminotransferase TD68_17095 ENOG41082BM Transcriptional regulator, arsr family TD68_17100 ENOG4108JUB Transcriptional regulator TD68_17110 ENOG4105C5H ABC transporter TD68_17125 ENOG4105CUZ uba thif-type nad fad binding protein TD68_17130 ENOG4105C0H protease TD68_17135 ENOG4105Q2H domain protein TD68_17150 ENOG4105BZU Histidine kinase TD68_17155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TD68_17180 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis TD68_17185 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase TD68_17190 ENOG4105CDU Replicative dna helicase TD68_17205 ENOG4105DJ2 Major Facilitator Superfamily TD68_17210 ENOG4105EDW glycosyl transferase, family 39 TD68_17215 ENOG4105K9Q Binds to the 23S rRNA (By similarity) TD68_17220 ENOG4105BZR domain protein TD68_17225 ENOG4108XMW Membrane TD68_17240 ENOG4105KVH Transcriptional regulator TD68_17245 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase TD68_17260 ENOG4105VMI -acetyltransferase TD68_17270 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) TD68_17275 ENOG4105DRR Transcriptional regulator, GntR family TD68_17280 ENOG41090E6 transcriptional regulator MERR family TD68_17290 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TD68_17305 ENOG4105DXI Major Facilitator superfamily TD68_17315 ENOG4105VFE sira family TD68_17330 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TD68_17335 ENOG4105C7Z Conserved Protein TD68_17345 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase TD68_17355 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) TD68_17365 ENOG4105CGK Exodeoxyribonuclease III TD68_17370 ENOG4108UZ3 Transporter TD68_17375 ENOG4108WYP Transcriptional regulator TD68_17385 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) TD68_17390 ENOG4108UUM single-stranded DNA-binding protein TD68_17395 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) TD68_17400 ENOG4105C3G gtp-binding protein TD68_17405 ENOG4108J2R molybdopterin oxidoreductase TD68_17410 ENOG4105VDK protein, conserved in bacteria TD68_17420 ENOG4108ZDA Sporulation protein YyaC TD68_17425 ENOG4105FA0 parb-like partition protein TD68_17430 ENOG4107QJE Chromosome Partitioning Protein TD68_17445 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) TD68_17450 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) TD68_17455 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) TD68_17470 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) TD68_17480 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) TD68_17485 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) TD68_17490 ENOG410848D S4 domain protein YaaA TD68_17505 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TD68_17510 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TD68_17535 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) TD68_17545 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) TD68_17550 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) TD68_17555 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) TD68_17565 ENOG4105ZMH deoxynucleoside kinase TD68_17575 ENOG4105VRS hydrolase family 18 TD68_17580 ENOG4105GTG Isochorismatase TD68_17585 ENOG4108Z6B deaminase TD68_17590 ENOG4105C6E dna polymerase iii TD68_17595 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) TD68_17600 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) TD68_17610 ENOG41067KS pro-sigma K processing TD68_17640 ENOG4105CDW Resistance protein TD68_17645 ENOG4105CXN decarboxylase TD68_17650 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) TD68_17655 ENOG4105X0R protein from nitrogen regulatory protein P-II TD68_17660 ENOG4105XVJ Protein of unknown function (DUF327) TD68_17665 ENOG4105FA2 dna polymerase iii TD68_17670 ENOG4105MA4 psp1 domain protein TD68_17680 ENOG41060K3 Methyltransferase TD68_17685 ENOG4105VC4 domain protein TD68_17690 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) TD68_17695 ENOG4105KRN Transcriptional regulator, abrb family TD68_17700 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) TD68_17705 ENOG4105F8V Hydrolase, tatD family TD68_17710 ENOG41069ER domain protein TD68_17720 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) TD68_17725 ENOG4105XFA sporulation peptidase YabG TD68_17730 ENOG4105W42 Veg protein TD68_17735 ENOG4105XEW small acid-soluble spore protein TD68_17740 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) TD68_17745 ENOG4105DFT pur operon repressor TD68_17750 ENOG4105KME endoribonuclease L-psp TD68_17755 ENOG4105K4W Could be involved in septation (By similarity) TD68_17760 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) TD68_17765 ENOG4105C5T Phosphoribosyl pyrophosphate synthase TD68_17770 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) TD68_17775 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) TD68_17785 ENOG4108JA2 transcriptioN-repair coupling factor TD68_17790 ENOG4108M14 stage v sporulation protein t TD68_17800 ENOG4108IY2 MazG family TD68_17805 ENOG41082I2 s4 domain protein TD68_17810 ENOG4105VYY sporulation protein yabp TD68_17825 ENOG41060GV RNA binding s1 domain protein TD68_17855 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) TD68_17860 ENOG4108UGV hypoxanthine phosphoribosyltransferase TD68_17865 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) TD68_17870 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) TD68_17875 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) TD68_17880 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase TD68_17885 ENOG4105C6T cysteine synthase TD68_17890 ENOG4105CRQ synthase (Component I) TD68_17895 ENOG4105DDQ anthranilate synthase TD68_17900 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 TD68_17905 ENOG4105EEI dihydropteroate synthase TD68_17910 ENOG4105KRF dihydroneopterin aldolase TD68_17915 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase TD68_17925 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) TD68_17930 ENOG4105CRK lysyL-tRNA synthetase TD68_18020 ENOG4108Z0C Uvrb UvrC protein TD68_18025 ENOG41066A3 ATP guanido phosphotransferase TD68_18035 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) TD68_18040 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) TD68_18045 ENOG4105CTP PilT protein domain protein TD68_18050 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) TD68_18055 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) TD68_18060 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) TD68_18065 ENOG4105D7W serine acetyltransferase TD68_18070 ENOG4105C8N cysteinyl-tRNA synthetase TD68_18075 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) TD68_18080 ENOG4105C2N RNA methyltransferase TrmH family group 3 TD68_18085 ENOG4105M0M Tetracycline resistance protein TD68_18105 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) TD68_18110 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) TD68_18120 ENOG4108VZM 50s ribosomal protein L10 TD68_18125 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) TD68_18130 ENOG4107Y49 methyltransferase TD68_18135 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TD68_18140 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TD68_18145 ENOG4105XPM ribosomal protein TD68_18150 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) TD68_18155 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) TD68_18160 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) TD68_18165 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) TD68_18170 ENOG4107SKW Inherit from COG: Alpha beta hydrolase TD68_18175 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) TD68_18180 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) TD68_18185 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) TD68_18190 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) TD68_18195 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity TD68_18200 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) TD68_18205 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) TD68_18210 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) TD68_18215 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) TD68_18220 ENOG41082SA 50s ribosomal protein l29 TD68_18225 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal TD68_18240 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits TD68_18250 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) TD68_18255 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) TD68_18260 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) TD68_18265 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) TD68_18270 ENOG4105VPB 50S ribosomal protein L30 TD68_18275 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) TD68_18280 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) TD68_18285 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) TD68_18290 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) TD68_18300 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) TD68_18310 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits TD68_18315 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) TD68_18320 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TD68_18325 ENOG4108ZT0 50S ribosomal protein l17 TD68_18330 ENOG4108JJB ABC transporter TD68_18335 ENOG4108JJB ABC transporter TD68_18340 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) TD68_18345 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) TD68_18350 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) TD68_18355 ENOG4108UJD 30S ribosomal protein S9 TD68_18360 ENOG4108I0C methyltransferase TD68_18375 ENOG4105D1F ATP-binding protein TD68_18390 ENOG4108NMV polysaccharide deacetylase TD68_18425 ENOG4108JPW Aminotransferase TD68_18435 ENOG4105CPQ Dehydrogenase TD68_18440 ENOG4105CHH sulfate transporter TD68_18450 ENOG4108SA1 esterase TD68_18470 ENOG410874W AraC family transcriptional regulator TD68_18475 ENOG4105EHZ conserved protein UCP016719 TD68_18480 ENOG4105D17 glycoside hydrolase, family 3 domain protein TD68_18500 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate TD68_18510 ENOG4105EWC Purine nucleoside phosphorylase TD68_18540 ENOG4105EMN RNA polymerase sigma factor TD68_18550 ENOG4105C8B TIGR00159 family TD68_18555 ENOG4107U5W ybbr family TD68_18560 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) TD68_18570 ENOG4108TWJ NADH dehydrogenase subunit 5 TD68_18590 ENOG4105GPN Uncharacterized conserved protein (DUF2294) TD68_18595 ENOG4105WAB arsR family transcriptional regulator TD68_18600 ENOG4108RWP Major Facilitator Superfamily protein TD68_18630 ENOG4105DY8 decarboxylase TD68_18640 ENOG41067MG lrgb family TD68_18650 ENOG41061AU MarR family Transcriptional regulator TD68_18660 ENOG4106DDH Sporulation-specific SASP protein TD68_18670 ENOG4108HWY Beta-lactamase TD68_18675 ENOG4107E6A Cytochrome p-450 TD68_18685 ENOG4107QTZ amino acid TD68_18690 ENOG4107VXM glycerophosphoryl diester phosphodiesterase TD68_18695 ENOG4105CXY transporter TD68_18710 ENOG4105EY8 ABC transporter TD68_18720 ENOG4107SJB teichoic acid biosynthesis TD68_18735 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase TD68_18760 ENOG410631K Membrane TD68_18765 ENOG4107SCQ Iron-containing alcohol dehydrogenase TD68_18770 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR TD68_18780 ENOG4108WC5 Alpha Beta Hydrolase Fold protein TD68_18785 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase TD68_18790 ENOG4107ZTW SNARE associated Golgi TD68_18800 ENOG4105D82 Glutamate dehydrogenase TD68_18810 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin TD68_18825 ENOG4105C72 UPF0176 protein TD68_18835 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane TD68_18835 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane TD68_18840 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) TD68_18845 ENOG4108X79 transcriptional regulator TD68_18855 ENOG4105CM2 brancheD-chain amino acid aminotransferase TD68_18860 ENOG4108IQI permease TD68_18865 ENOG4108J5H Homocysteine s-methyltransferase TD68_18875 ENOG4105CSV Glutaminase TD68_18890 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase TD68_18895 ENOG4105C26 Dehydrogenase TD68_18900 ENOG4105DJB Major Facilitator Superfamily TD68_18905 ENOG4105EQX glucarate dehydratase TD68_18910 ENOG41073TP transcriptional regulator TD68_18915 ENOG4105CTX dehydratase TD68_18935 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TD68_18975 ENOG4105DGI Alkaline phosphatase TD68_18980 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) TD68_18985 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) TD68_18990 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) TD68_18995 ENOG4107EPV Aminotransferase class V TD68_19000 ENOG4105C0R drug resistance transporter emrb qaca subfamily TD68_19005 ENOG4105J7D transcriptional regulator TD68_19010 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold TD68_19015 ENOG41060AI SEC-C motif TD68_19020 ENOG4107SET aldo keto reductase TD68_19035 ENOG4105G5W regulator Fur family TD68_19055 ENOG4105H9W Short-chain dehydrogenase reductase Sdr TD68_19065 ENOG4105DSE periplasmic solute binding protein TD68_19070 ENOG4105DIK (ABC) transporter TD68_19080 ENOG4105DEN Luciferase family TD68_19085 ENOG4108N0M stress protein TD68_19090 ENOG4106FN3 tellurium resistance protein TD68_19095 ENOG4106FN3 tellurium resistance protein TD68_19100 ENOG4107TS3 membrane protein, TerC TD68_19125 ENOG4108TTB tellurium resistance protein TD68_19135 ENOG41079KZ Major Facilitator Superfamily TD68_19140 ENOG4108IJ7 Glycine betaine TD68_19145 ENOG4107SQ8 Glycine betaine TD68_19170 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) TD68_19205 ENOG4105EIG urea carboxylase-associated protein 1 TD68_19210 ENOG4107RA1 nh(3)-dependent nad( ) synthetase TD68_19215 ENOG4105I1F Resistance protein TD68_19220 ENOG4108WBH protein TIM barrel TD68_19225 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) TD68_19235 ENOG4105I82 acetyl xylan esterase TD68_19240 ENOG410756H nucleotidyltransferase TD68_19250 ENOG4105C26 Dehydrogenase TD68_19255 ENOG4105CK7 Sodium proline symporter TD68_19260 ENOG4107YHD transcriptional regulator TD68_19285 ENOG4108PJD permease TD68_19290 ENOG4105U6C Alpha beta hydrolase fold protein TD68_19300 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) TD68_19305 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit TD68_19310 ENOG4108IFG nitrite reductase, (NAD(P)H) TD68_19315 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) TD68_19335 ENOG4105S7A ErfK ybiS ycfS ynhG family protein TD68_19340 ENOG4105CKI cobalamin synthesis protein TD68_19345 ENOG4105E5Q amino acid AbC transporter TD68_19350 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein TD68_19355 ENOG4105E2A Dehydrogenase TD68_19360 ENOG4105HHM rdd domain containing protein TD68_19385 ENOG4105CS2 ec 3.2.1.21 TD68_19400 ENOG4105C8Q Methyl-accepting chemotaxis TD68_19405 ENOG41080HJ 6-phospho 3-hexuloisomerase TD68_19410 ENOG4108VA3 3-hexulose-6-phosphate synthase TD68_19415 ENOG4105KVH Transcriptional regulator TD68_19420 ENOG4105CEY Amp-dependent synthetase and ligase TD68_19445 ENOG4105SX7 Transporter TD68_19455 ENOG4105W8Z 4'-phosphopantetheinyl transferase TD68_19465 ENOG4105CDA abc transporter atp-binding protein TD68_19470 ENOG4105DRP amino acid AbC transporter TD68_19480 ENOG4106P55 Transcriptional regulator TD68_19485 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase TD68_19490 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) TD68_19495 ENOG41069ZX TD68_19500 ENOG41069ZX TD68_19510 ENOG4105DUX Transporter TD68_19525 ENOG4105E1K spore germination protein TD68_19540 ENOG4105CPU Monooxygenase TD68_19545 ENOG4108XSB acetyltransferase, (GNAT) family TD68_19550 ENOG4105EAB amino acid AbC transporter TD68_19555 ENOG4108HW4 amino acid AbC transporter TD68_19565 ENOG4105CH2 amidohydrolase TD68_19570 ENOG4108PGP mmge prpd family protein TD68_19585 ENOG4105CFH Aspartokinase TD68_19590 ENOG4105DHS permease protein TD68_19595 ENOG4105CM4 permease protein TD68_19600 ENOG4108IPW abc transporter atp-binding protein TD68_19615 ENOG4105R8C Transcriptional regulator TD68_19620 ENOG410780I phosphoprotein phosphatase activity TD68_19625 ENOG4108DBC nitroreductase TD68_19630 ENOG41067V3 Antibiotic biosynthesis monooxygenase TD68_19635 ENOG4105YVS arsR family transcriptional regulator TD68_19645 ENOG4108JPW Aminotransferase TD68_19650 ENOG4105C26 Dehydrogenase TD68_19660 ENOG4105H9W Short-chain dehydrogenase reductase Sdr TD68_19665 ENOG4105KTB nuclear export factor GLE1 TD68_19670 ENOG4108T5E Copper resistance protein TD68_19675 ENOG4108ZYE Transcriptional regulator TD68_19720 ENOG4105E7W lamb ycsf family protein TD68_19725 ENOG4105C5A transporter TD68_19730 ENOG4105CFM UPF0317 protein TD68_19735 ENOG4105P4J Allophanate hydrolase, subunit 1 TD68_19745 ENOG4107258 Transcriptional regulator TD68_19750 ENOG4105XJB lipolytic protein G-D-S-L family TD68_19760 ENOG41061CK Antibiotic biosynthesis monooxygenase TD68_19765 ENOG4107RVG penicillin-binding protein TD68_19770 ENOG4107QM2 Aldo Keto reductase TD68_19775 ENOG4105ETD TRANSCRIPTIONal TD68_19785 ENOG4105HMZ Methyltransferase TD68_19790 ENOG4105CYX Short-chain dehydrogenase reductase Sdr TD68_19800 ENOG410606W general stress protein TD68_19815 ENOG4105VCH membrane TD68_19835 ENOG4105C9U ATP-dependent DNA helicase RecQ TD68_19850 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) TD68_19855 ENOG4107R8N Glycosyl transferase, family 2 TD68_19865 ENOG4105C0X amino acid TD68_19885 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) TD68_19890 ENOG4107BMA Transglycosylase associated protein TD68_19895 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) TD68_19900 ENOG4105EU9 TD68_19905 ENOG4105QVS general stress protein TD68_19910 ENOG41082W1 Cupin 2, conserved barrel domain protein TD68_19925 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit TD68_19930 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism TD68_19935 ENOG4108MRH transcriptional regulatory protein TD68_19940 ENOG4107QJT sodium dicarboxylate symporter TD68_19945 ENOG4106F5Q Membrane TD68_19950 ENOG4105CJ1 ABC, transporter TD68_19965 ENOG4105FDT acyl-CoA dehydrogenase TD68_19980 ENOG4105SZ6 Thioredoxin TD68_19985 ENOG4105CPF Cell wall formation (By similarity) TD68_19990 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) TD68_20000 ENOG4105C1J atp-dependent rna helicase TD68_20005 ENOG410905X membrane-flanked domain protein TD68_20010 ENOG4105CKV Membrane TD68_20020 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) TD68_20025 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein TD68_20030 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) TD68_20040 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) TD68_20045 ENOG4107MMM Anti-sigma-factor antagonist TD68_20050 ENOG4105FUA antagonist TD68_20055 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase TD68_20060 ENOG4107SGM protein serine threonine phosphatase TD68_20065 ENOG4105WN5 stage II sporulation protein TD68_20070 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) TD68_20080 ENOG41064BQ Phosphatase TD68_20130 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) TD68_20135 ENOG41068WC Domain of unknown function (DUF955) TD68_20140 ENOG4108IMY Transcriptional regulator TD68_20160 ENOG4108RYM conjugative transposon protein TD68_20170 ENOG4106BHR ftsk SpoIIIE family protein TD68_20175 ENOG4106128 DNA-binding helix-turn-helix protein TD68_20240 ENOG4105K4H Nlp p60 protein TD68_20270 ENOG4105ECK Fatty Acid Desaturase TD68_20275 ENOG4105VEQ Cold shock protein TD68_20280 ENOG4108VJ1 Transcriptional regulator (CarD family TD68_20285 ENOG4105DRR Transcriptional regulator, GntR family TD68_20300 ENOG4106BHF TD68_20310 ENOG4108U05 Transcriptional regulator TD68_20315 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 TD68_20325 ENOG4107U9B transcriptional regulator TD68_20330 ENOG4105JAB phenazine biosynthesis protein, phzf family TD68_20340 ENOG4105T38 integral membrane protein TD68_20345 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TD68_20360 ENOG41082YX Transcriptional regulator, arsr family TD68_20365 ENOG4107R5R arsenical pump membrane protein TD68_20370 ENOG4108UXE Protein tyrosine phosphatase TD68_20380 ENOG4105E1V na solute symporter TD68_20390 ENOG41062A4 Transcriptional regulator TD68_20395 ENOG4105EYF MMPL domain protein TD68_20405 ENOG4105DM4 PTS System TD68_20410 ENOG4105DG6 mannose-6-phosphate isomerase TD68_20415 ENOG4107Y9U Membrane TD68_20425 ENOG4105Z7P Acetyltransferase (GNAT) family TD68_20430 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein TD68_20450 ENOG4108VQT Alpha beta hydrolase fold protein TD68_20465 ENOG4108HWY Beta-lactamase TD68_20475 ENOG4105C2C drug resistance transporter, Bcr CflA TD68_20485 ENOG4105VRS hydrolase family 18