locus-tag	class	description
HCU65_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HCU65_00010	COG0592	DNA-directed DNA polymerase activity
HCU65_00015	COG2501	S4 domain
HCU65_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCU65_00030	COG0187	DNA topoisomerase II activity
HCU65_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCU65_00070	COG0516	GMP reductase activity
HCU65_00070	COG0517	IMP dehydrogenase activity
HCU65_00075	COG1686	Belongs to the peptidase S11 family
HCU65_00100	COG1428	Deoxynucleoside kinase
HCU65_00105	COG1428	Deoxynucleoside kinase
HCU65_00110	COG1388	LysM domain
HCU65_00110	COG3858	chitin binding
HCU65_00115	COG1335	isochorismatase
HCU65_00120	COG0590	tRNA wobble adenosine to inosine editing
HCU65_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HCU65_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HCU65_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HCU65_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HCU65_00190	COG3853	Toxic anion resistance protein (TelA)
HCU65_00195	COG1982	Orn Lys Arg decarboxylase major
HCU65_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HCU65_00205	COG3870	Protein conserved in bacteria
HCU65_00210	COG1728	Protein conserved in bacteria
HCU65_00215	COG0470	DNA polymerase III
HCU65_00220	COG1774	PSP1 C-terminal conserved region
HCU65_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HCU65_00235	COG2827	Endonuclease containing a URI domain
HCU65_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HCU65_00245	COG2002	toxin-antitoxin pair type II binding
HCU65_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCU65_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCU65_00255	COG0084	hydrolase, TatD family'
HCU65_00260	COG3583	domain protein
HCU65_00260	COG3584	3D domain protein
HCU65_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HCU65_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HCU65_00280	COG4466	Protein conserved in bacteria
HCU65_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HCU65_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCU65_00300	COG0251	oxidation-reduction process
HCU65_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HCU65_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HCU65_00325	COG0193	aminoacyl-tRNA hydrolase activity
HCU65_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HCU65_00340	COG2002	toxin-antitoxin pair type II binding
HCU65_00345	COG2244	polysaccharide biosynthetic process
HCU65_00350	COG3956	TIGRFAM MazG family protein
HCU65_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HCU65_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HCU65_00375	COG1098	S1 RNA binding domain
HCU65_00390	COG2208	phosphoserine phosphatase activity
HCU65_00395	COG2304	oxidoreductase activity
HCU65_00400	COG0515	serine threonine protein kinase
HCU65_00405	COG0037	tRNA processing
HCU65_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HCU65_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCU65_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCU65_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCU65_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCU65_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
HCU65_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCU65_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCU65_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCU65_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HCU65_00470	COG1396	sequence-specific DNA binding
HCU65_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCU65_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCU65_00560	COG4463	regulation of RNA biosynthetic process
HCU65_00565	COG3880	PFAM UvrB UvrC protein
HCU65_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HCU65_00575	COG0542	response to heat
HCU65_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HCU65_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HCU65_00590	COG4956	integral membrane protein (PIN domain superfamily)
HCU65_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HCU65_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HCU65_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCU65_00610	COG1045	serine acetyltransferase
HCU65_00615	COG0215	cysteine-tRNA ligase activity
HCU65_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HCU65_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCU65_00630	COG3688	RNA-binding protein containing a PIN domain
HCU65_00635	COG1595	DNA-templated transcription, initiation
HCU65_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCU65_00650	COG0250	Participates in transcription elongation, termination and antitermination
HCU65_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HCU65_00675	COG2813	Specifically methylates the guanine in position
HCU65_00680	COG0085	RNA polymerase activity
HCU65_00690	COG1358	cellular component organization or biogenesis
HCU65_00700	COG0049	tRNA binding
HCU65_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCU65_00715	COG0596	Alpha beta hydrolase
HCU65_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HCU65_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HCU65_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HCU65_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HCU65_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HCU65_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HCU65_00820	COG0200	Binds to the 23S rRNA
HCU65_00825	COG0201	protein transport
HCU65_00835	COG0024	Methionine aminopeptidase
HCU65_00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
HCU65_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HCU65_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HCU65_00870	COG0203	ribosomal protein L17
HCU65_00875	COG1122	ATPase activity
HCU65_00880	COG1122	ATPase activity
HCU65_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HCU65_00890	COG0101	tRNA pseudouridine synthase activity
HCU65_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HCU65_00905	COG2226	methyltransferase
HCU65_00910	COG2318	DinB family
HCU65_00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCU65_00925	COG0489	protein tyrosine kinase activity
HCU65_00935	COG2194	sulfuric ester hydrolase activity
HCU65_00940	COG0726	polysaccharide deacetylase
HCU65_00970	COG0738	Major facilitator superfamily
HCU65_00975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCU65_00985	COG1063	alcohol dehydrogenase
HCU65_00990	COG0659	secondary active sulfate transmembrane transporter activity
HCU65_00995	COG0385	Bile acid
HCU65_01000	COG2819	hydrolase of the alpha beta superfamily
HCU65_01005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU65_01010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU65_01015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCU65_01020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCU65_01020	COG2207	Transcriptional regulator
HCU65_01025	COG3876	Protein conserved in bacteria
HCU65_01030	COG1472	Belongs to the glycosyl hydrolase 3 family
HCU65_01035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCU65_01040	COG1263	PTS System
HCU65_01040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU65_01045	COG1737	Transcriptional regulator
HCU65_01050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HCU65_01055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCU65_01060	COG1683	Conserved Protein
HCU65_01090	COG1595	DNA-templated transcription, initiation
HCU65_01095	COG5662	AntiSigma factor
HCU65_01100	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HCU65_01105	COG4856	YbbR-like protein
HCU65_01110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCU65_01120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCU65_01125	COG3002	Belongs to the UPF0753 family
HCU65_01130	COG0288	reversible hydration of carbon dioxide
HCU65_01140	COG5609	conserved protein (DUF2294)
HCU65_01145	COG0640	Transcriptional regulator
HCU65_01150	COG2814	Major facilitator Superfamily
HCU65_01160	COG0535	radical SAM domain protein
HCU65_01165	COG1266	CAAX protease self-immunity
HCU65_01170	COG1131	(ABC) transporter
HCU65_01180	COG1413	lyase activity
HCU65_01185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCU65_01200	COG0076	glutamate decarboxylase activity
HCU65_01215	COG1346	cytolysis
HCU65_01220	COG1380	Effector of murein hydrolase LrgA
HCU65_01225	COG1846	Transcriptional regulator
HCU65_01230	COG1113	amino acid transport
HCU65_01245	COG2602	Beta-lactamase
HCU65_01250	COG2124	cytochrome p450
HCU65_01260	COG0531	amino acid
HCU65_01265	COG0584	glycerophosphoryl diester phosphodiesterase
HCU65_01270	COG2271	Major facilitator Superfamily
HCU65_01300	COG1397	ADP-ribosylglycohydrolase
HCU65_01305	COG5444	nuclease activity
HCU65_01320	COG0371	Dehydrogenase
HCU65_01325	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HCU65_01335	COG0596	Alpha beta hydrolase
HCU65_01340	COG1183	phosphatidylcholine synthase activity
HCU65_01345	COG0586	Pfam SNARE associated Golgi protein
HCU65_01350	COG0688	phosphatidylethanolamine metabolic process
HCU65_01355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCU65_01365	COG1404	Belongs to the peptidase S8 family
HCU65_01370	COG2312	Erythromycin esterase
HCU65_01375	COG2207	Transcriptional regulator
HCU65_01380	COG1054	Belongs to the UPF0176 family
HCU65_01385	COG1301	dicarboxylic acid transport
HCU65_01390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU65_01390	COG2190	(PTS) system
HCU65_01390	COG1263	PTS System
HCU65_01395	COG0363	glucosamine-6-phosphate deaminase activity
HCU65_01400	COG2188	Transcriptional regulator
HCU65_01410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCU65_01415	COG0833	amino acid
HCU65_01420	COG2040	homocysteine
HCU65_01425	COG1115	amino acid carrier protein
HCU65_01430	COG2066	Belongs to the glutaminase family
HCU65_01435	COG4191	Histidine kinase
HCU65_01440	COG0784	Response regulator, receiver
HCU65_01445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCU65_01450	COG1012	belongs to the aldehyde dehydrogenase family
HCU65_01455	COG2271	Major facilitator Superfamily
HCU65_01460	COG4948	Mandelate Racemase Muconate Lactonizing
HCU65_01465	COG2186	Transcriptional regulator
HCU65_01470	COG2721	sulfolactate sulfo-lyase activity
HCU65_01475	COG3173	Aminoglycoside phosphotransferase
HCU65_01490	COG0745	RESPONSE REGULATOR receiver
HCU65_01495	COG2205	protein histidine kinase activity
HCU65_01500	COG1131	(ABC) transporter
HCU65_01525	COG3773	Cell wall hydrolase
HCU65_01530	COG3540	Alkaline phosphatase
HCU65_01535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCU65_01540	COG0805	protein transport
HCU65_01550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCU65_01555	COG0477	Major facilitator Superfamily
HCU65_01560	COG1309	transcriptional regulator
HCU65_01565	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HCU65_01570	COG1405	negative regulation of cell septum assembly
HCU65_01570	COG3012	SEC-C Motif Domain Protein
HCU65_01575	COG0667	Aldo Keto reductase
HCU65_01585	COG1595	DNA-templated transcription, initiation
HCU65_01590	COG0735	belongs to the Fur family
HCU65_01595	COG1595	DNA-templated transcription, initiation
HCU65_01600	COG1876	peptidase activity
HCU65_01605	COG0457	Tetratricopeptide repeat
HCU65_01610	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_01615	COG0366	Alpha amylase catalytic
HCU65_01620	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCU65_01625	COG1121	(ABC) transporter
HCU65_01630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCU65_01635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCU65_01640	COG2310	stress, protein
HCU65_01645	COG2310	stress, protein
HCU65_01650	COG2310	stress, protein
HCU65_01655	COG0861	Integral membrane protein TerC family
HCU65_01685	COG3853	Toxic anion resistance protein (TelA)
HCU65_01690	COG0477	Major facilitator Superfamily
HCU65_01695	COG4175	Glycine betaine
HCU65_01695	COG0517	IMP dehydrogenase activity
HCU65_01700	COG4176	ABC-type proline glycine betaine transport system permease component
HCU65_01705	COG2113	Glycine betaine
HCU65_01710	COG1473	amidohydrolase
HCU65_01715	COG1288	antiporter activity
HCU65_01725	COG0039	L-malate dehydrogenase activity
HCU65_01730	COG1620	l-lactate permease
HCU65_01735	COG2814	Major facilitator Superfamily
HCU65_01740	COG1846	Transcriptional regulator
HCU65_01745	COG1280	lysine exporter protein (LysE YggA)
HCU65_01750	COG3403	YqcI/YcgG family
HCU65_01755	COG1113	amino acid transport
HCU65_01760	COG3665	Urea carboxylase-associated protein
HCU65_01770	COG1660	Displays ATPase and GTPase activities
HCU65_01775	COG1082	Xylose isomerase domain protein TIM barrel
HCU65_01780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCU65_01790	COG3458	cephalosporin-C deacetylase activity
HCU65_01795	COG3541	Predicted nucleotidyltransferase
HCU65_01800	COG0506	proline dehydrogenase activity
HCU65_01805	COG1012	belongs to the aldehyde dehydrogenase family
HCU65_01810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCU65_01815	COG2508	Transcriptional regulator
HCU65_01820	COG3689	TIGRFAM TIGR03943 family protein
HCU65_01825	COG0701	Predicted permease
HCU65_01830	COG2267	carboxylic ester hydrolase activity
HCU65_01835	COG0492	ferredoxin-NADP+ reductase activity
HCU65_01840	COG1587	Uroporphyrinogen-III synthase
HCU65_01840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCU65_01845	COG2146	nitrite reductase [NAD(P)H] activity
HCU65_01850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCU65_01855	COG0243	molybdopterin cofactor binding
HCU65_01860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCU65_01870	COG1469	GTP cyclohydrolase I activity
HCU65_01875	COG1376	ErfK ybiS ycfS ynhG family protein
HCU65_01880	COG0523	cobalamin synthesis protein
HCU65_01885	COG0765	amino acid transport
HCU65_01890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCU65_01895	COG1063	alcohol dehydrogenase
HCU65_01900	COG1714	RDD family
HCU65_01925	COG2723	6-phospho-beta-galactosidase activity
HCU65_01935	COG3209	COG3209 Rhs family protein
HCU65_01940	COG0840	transmembrane signaling receptor activity
HCU65_01940	COG3290	protein histidine kinase activity
HCU65_01945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HCU65_01950	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HCU65_01955	COG1733	regulation of RNA biosynthetic process
HCU65_01960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCU65_01965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCU65_01970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCU65_01975	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HCU65_01985	COG0697	spore germination
HCU65_01990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCU65_02000	COG2364	Membrane
HCU65_02005	COG1126	abc transporter atp-binding protein
HCU65_02010	COG0765	amino acid transport
HCU65_02015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCU65_02020	COG0583	DNA-binding transcription factor activity
HCU65_02025	COG0163	prenyltransferase activity
HCU65_02030	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCU65_02045	COG0596	Alpha beta hydrolase
HCU65_02050	COG3104	oligopeptide transport
HCU65_02055	COG5434	Belongs to the glycosyl hydrolase 28 family
HCU65_02065	COG0697	spore germination
HCU65_02075	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HCU65_02080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCU65_02085	COG0456	acetyltransferase
HCU65_02090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCU65_02095	COG0765	amino acid transport
HCU65_02100	COG1126	abc transporter atp-binding protein
HCU65_02105	COG1473	amidohydrolase
HCU65_02110	COG2079	MmgE PrpD family protein
HCU65_02120	COG0457	Tetratricopeptide repeat
HCU65_02140	COG0527	aspartate kinase activity
HCU65_02145	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU65_02150	COG4605	iron ion homeostasis
HCU65_02155	COG4604	ABC transporter, ATP-binding protein
HCU65_02160	COG4607	ABC-type enterochelin transport system periplasmic component
HCU65_02165	COG2814	Major facilitator Superfamily
HCU65_02170	COG1309	transcriptional regulator
HCU65_02175	COG0457	Tetratricopeptide repeat
HCU65_02180	COG0778	Nitroreductase
HCU65_02185	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HCU65_02190	COG0640	Transcriptional regulator
HCU65_02195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCU65_02200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCU65_02205	COG1012	belongs to the aldehyde dehydrogenase family
HCU65_02210	COG4975	Glucose uptake
HCU65_02215	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_02220	COG4549	nuclear export factor GLE1
HCU65_02225	COG1276	copper resistance
HCU65_02225	COG2372	response to copper ion
HCU65_02230	COG1349	DNA-binding transcription factor activity
HCU65_02240	COG2213	PTS system mannitol-specific
HCU65_02245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU65_02250	COG0246	Mannitol dehydrogenase
HCU65_02255	COG0412	Dienelactone hydrolase
HCU65_02260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCU65_02275	COG0561	phosphatase activity
HCU65_02280	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HCU65_02285	COG1914	H( )-stimulated, divalent metal cation uptake system
HCU65_02290	COG4336	lyase activity
HCU65_02295	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HCU65_02300	COG1984	allophanate hydrolase subunit 2
HCU65_02305	COG1414	Transcriptional regulator
HCU65_02310	COG2755	lipolytic protein G-D-S-L family
HCU65_02320	COG2329	Antibiotic biosynthesis monooxygenase
HCU65_02325	COG0768	penicillin binding
HCU65_02330	COG4989	oxidoreductase activity
HCU65_02335	COG3711	transcriptional antiterminator
HCU65_02340	COG0318	PFAM AMP-dependent synthetase and ligase
HCU65_02345	COG2226	methyltransferase
HCU65_02350	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_02355	COG1917	Cupin 2, conserved barrel domain protein
HCU65_02360	COG3871	stress protein (general stress protein 26)
HCU65_02375	COG2814	Major facilitator Superfamily
HCU65_02390	COG1522	sequence-specific DNA binding
HCU65_02395	COG0551	DNA topoisomerase type I activity
HCU65_02395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCU65_02400	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HCU65_02405	COG3706	GGDEF domain
HCU65_02410	COG5298	Protein conserved in bacteria
HCU65_02415	COG1215	transferase activity, transferring glycosyl groups
HCU65_02425	COG0531	amino acid
HCU65_02435	COG0028	Belongs to the TPP enzyme family
HCU65_02460	COG1914	H( )-stimulated, divalent metal cation uptake system
HCU65_02465	COG2261	transglycosylase associated protein
HCU65_02470	COG4876	unkown
HCU65_02475	COG2217	Heavy metal translocating P-type atpase
HCU65_02480	COG3729	General stress protein
HCU65_02485	COG0662	Cupin 2, conserved barrel domain protein
HCU65_02490	COG2329	Antibiotic biosynthesis monooxygenase
HCU65_02495	COG3546	catalase activity
HCU65_02500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HCU65_02505	COG3290	protein histidine kinase activity
HCU65_02510	COG4565	transcriptional regulatory protein
HCU65_02515	COG1301	dicarboxylic acid transport
HCU65_02520	COG0628	permease
HCU65_02525	COG1131	(ABC) transporter
HCU65_02530	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HCU65_02540	COG1960	acyl-CoA dehydrogenase activity
HCU65_02555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HCU65_02560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCU65_02565	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCU65_02570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCU65_02580	COG0513	Belongs to the DEAD box helicase family
HCU65_02585	COG3402	PFAM membrane-flanked domain
HCU65_02590	COG3428	Bacterial PH domain
HCU65_02595	COG0705	Rhomboid family
HCU65_02600	COG0736	holo-[acyl-carrier-protein] synthase activity
HCU65_02605	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HCU65_02610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCU65_02615	COG0864	Transcriptional regulator
HCU65_02620	COG2337	Toxic component of a toxin-antitoxin (TA) module
HCU65_02625	COG1366	Belongs to the anti-sigma-factor antagonist family
HCU65_02630	COG1366	Belongs to the anti-sigma-factor antagonist family
HCU65_02635	COG2172	sigma factor antagonist activity
HCU65_02640	COG2208	phosphoserine phosphatase activity
HCU65_02645	COG1366	Belongs to the anti-sigma-factor antagonist family
HCU65_02650	COG2172	sigma factor antagonist activity
HCU65_02655	COG1191	sigma factor activity
HCU65_02660	COG2208	phosphoserine phosphatase activity
HCU65_02665	COG2183	response to ionizing radiation
HCU65_02675	COG3091	SprT-like family
HCU65_02740	COG3048	D-serine ammonia-lyase activity
HCU65_02745	COG3239	Fatty acid desaturase
HCU65_02755	COG1278	Cold shock
HCU65_02760	COG1329	Transcriptional regulator
HCU65_02765	COG1802	Transcriptional regulator
HCU65_02770	COG0697	spore germination
HCU65_02785	COG2364	Membrane
HCU65_02790	COG1846	Transcriptional regulator
HCU65_02795	COG0456	acetyltransferase
HCU65_02800	COG2808	Putative FMN-binding domain
HCU65_02815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCU65_02825	COG2814	Major facilitator Superfamily
HCU65_02835	COG0697	spore germination
HCU65_02840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCU65_02845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCU65_02855	COG0640	Transcriptional regulator
HCU65_02860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCU65_02865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCU65_02880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCU65_02895	COG1621	beta-fructofuranosidase activity
HCU65_02900	COG3716	PTS system mannose fructose sorbose family IID component
HCU65_02905	COG3715	PTS system
HCU65_02910	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU65_02915	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU65_02920	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HCU65_02920	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HCU65_02930	COG1846	Transcriptional regulator
HCU65_02935	COG2409	Drug exporters of the RND superfamily
HCU65_02935	COG1033	growth of symbiont in host cell
HCU65_02945	COG3711	transcriptional antiterminator
HCU65_02945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU65_02950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU65_02950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCU65_02950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCU65_02955	COG1482	cell wall glycoprotein biosynthetic process
HCU65_02965	COG0697	spore germination
HCU65_02970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCU65_02975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCU65_02980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HCU65_02985	COG1522	sequence-specific DNA binding
HCU65_02995	COG0488	(ABC) transporter
HCU65_03005	COG2602	Beta-lactamase
HCU65_03015	COG2814	Major facilitator Superfamily
HCU65_03025	COG3858	chitin binding
HCU65_03025	COG1388	LysM domain
HCU65_03030	COG1819	glycosyl
HCU65_03045	COG1785	Belongs to the alkaline phosphatase family
HCU65_03055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCU65_03060	COG1125	glycine betaine transport
HCU65_03060	COG0517	IMP dehydrogenase activity
HCU65_03065	COG1174	glycine betaine transport
HCU65_03070	COG5434	Belongs to the glycosyl hydrolase 28 family
HCU65_03075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCU65_03090	COG2814	Major facilitator Superfamily
HCU65_03095	COG2186	Transcriptional regulator
HCU65_03100	COG2807	transmembrane transport
HCU65_03115	COG1378	Sugar-specific transcriptional regulator TrmB
HCU65_03155	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HCU65_03160	COG0802	atpase or kinase
HCU65_03165	COG1214	PFAM Peptidase M22, glycoprotease
HCU65_03170	COG0456	acetyltransferase
HCU65_03175	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HCU65_03180	COG0488	(ABC) transporter
HCU65_03185	COG0315	cyclic pyranopterin monophosphate synthase activity
HCU65_03195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCU65_03200	COG0805	protein transport
HCU65_03210	COG1266	CAAX protease self-immunity
HCU65_03250	COG0457	Tetratricopeptide repeat
HCU65_03255	COG1063	alcohol dehydrogenase
HCU65_03260	COG2211	Major facilitator Superfamily
HCU65_03265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCU65_03275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCU65_03280	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HCU65_03285	COG4260	virion core protein, lumpy skin disease virus
HCU65_03295	COG1595	DNA-templated transcription, initiation
HCU65_03305	COG0778	Nitroreductase
HCU65_03310	COG1846	Transcriptional regulator
HCU65_03315	COG2814	Major facilitator Superfamily
HCU65_03320	COG1063	alcohol dehydrogenase
HCU65_03325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCU65_03330	COG0823	Involved in the tonB-independent uptake of proteins
HCU65_03340	COG2267	carboxylic ester hydrolase activity
HCU65_03350	COG2132	Multicopper oxidase
HCU65_03355	COG1113	amino acid transport
HCU65_03365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HCU65_03370	COG0714	Associated with various cellular activities
HCU65_03375	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HCU65_03380	COG1305	Transglutaminase-like
HCU65_03385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HCU65_03385	COG0519	Catalyzes the synthesis of GMP from XMP
HCU65_03400	COG2252	PERMEase
HCU65_03405	COG3064	Membrane
HCU65_03415	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HCU65_03425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCU65_03430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HCU65_03435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCU65_03440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HCU65_03445	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCU65_03450	COG0047	phosphoribosylformylglycinamidine synthase activity
HCU65_03455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCU65_03460	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HCU65_03470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HCU65_03475	COG0138	bifunctional purine biosynthesis protein purh
HCU65_03480	COG0151	Belongs to the GarS family
HCU65_03485	COG1522	sequence-specific DNA binding
HCU65_03490	COG0531	amino acid
HCU65_03500	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HCU65_03505	COG1470	cell adhesion involved in biofilm formation
HCU65_03510	COG4496	protein, YerC YecD
HCU65_03515	COG0069	glutamate synthase activity
HCU65_03520	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HCU65_03525	COG0210	DNA helicase
HCU65_03530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCU65_03535	COG4851	CamS sex pheromone cAM373 precursor
HCU65_03540	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCU65_03545	COG1285	pathogenesis
HCU65_03550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCU65_03560	COG0154	amidase activity
HCU65_03570	COG1309	transcriptional regulator
HCU65_03575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCU65_03580	COG1597	lipid kinase activity
HCU65_03585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCU65_03630	COG5444	nuclease activity
HCU65_03635	COG0457	Tetratricopeptide repeat
HCU65_03655	COG0457	Tetratricopeptide repeat
HCU65_03680	COG3546	catalase activity
HCU65_03685	COG0454	-acetyltransferase
HCU65_03695	COG5578	integral membrane protein
HCU65_03700	COG2972	Histidine kinase
HCU65_03705	COG2207	Transcriptional regulator
HCU65_03705	COG4753	response regulator
HCU65_03710	COG1653	transport
HCU65_03715	COG1175	transmembrane transport
HCU65_03720	COG0395	ABC-type sugar transport system, permease component
HCU65_03725	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HCU65_03730	COG2207	Transcriptional regulator
HCU65_03735	COG2755	lipolytic protein G-D-S-L family
HCU65_03745	COG5578	integral membrane protein
HCU65_03750	COG3401	FG-GAP repeat protein
HCU65_03755	COG3401	FG-GAP repeat protein
HCU65_03760	COG2755	lipolytic protein G-D-S-L family
HCU65_03765	COG1874	Beta-galactosidase
HCU65_03775	COG1653	transport
HCU65_03780	COG4209	transmembrane transport
HCU65_03785	COG0395	ABC-type sugar transport system, permease component
HCU65_03790	COG1486	melibiose metabolic process
HCU65_03795	COG2323	membrane
HCU65_03800	COG2329	Antibiotic biosynthesis monooxygenase
HCU65_03805	COG0346	lactoylglutathione lyase activity
HCU65_03810	COG1366	Belongs to the anti-sigma-factor antagonist family
HCU65_03815	COG5583	Uncharacterized small protein (DUF2292)
HCU65_03820	COG0196	riboflavin kinase activity
HCU65_03825	COG0670	Belongs to the BI1 family
HCU65_03835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCU65_03835	COG2124	cytochrome p450
HCU65_03840	COG1368	sulfuric ester hydrolase activity
HCU65_03845	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCU65_03850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCU65_03855	COG1442	glycosyl transferase family 8
HCU65_03860	COG1216	Glycosyl transferase, family 2
HCU65_03865	COG1442	glycosyl transferase family 8
HCU65_03870	COG2223	nitrite transmembrane transporter activity
HCU65_03875	COG0531	amino acid
HCU65_03880	COG1012	belongs to the aldehyde dehydrogenase family
HCU65_03885	COG0840	transmembrane signaling receptor activity
HCU65_03890	COG0463	Glycosyl transferase, family 2
HCU65_03895	COG0488	(ABC) transporter
HCU65_03900	COG0789	Transcriptional regulator
HCU65_03905	COG2814	Major facilitator Superfamily
HCU65_03910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCU65_03915	COG0488	(ABC) transporter
HCU65_03920	COG0513	Belongs to the DEAD box helicase family
HCU65_03925	COG2130	NADP-dependent
HCU65_03930	COG1120	ATPase activity
HCU65_03935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU65_03940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU65_03945	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HCU65_03960	COG3866	Pectate lyase
HCU65_03965	COG0471	metal ion transport
HCU65_03980	COG3290	protein histidine kinase activity
HCU65_03985	COG4565	transcriptional regulatory protein
HCU65_03990	COG3181	Tripartite tricarboxylate transporter family receptor
HCU65_03995	COG2851	Citrate transporter
HCU65_04000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCU65_04005	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HCU65_04010	COG1254	Belongs to the acylphosphatase family
HCU65_04015	COG2258	MOSC domain
HCU65_04035	COG0024	Methionine aminopeptidase
HCU65_04040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU65_04040	COG1263	PTS System
HCU65_04045	COG1368	sulfuric ester hydrolase activity
HCU65_04055	COG1115	amino acid carrier protein
HCU65_04060	COG1263	PTS System
HCU65_04060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU65_04065	COG0366	Alpha amylase catalytic
HCU65_04070	COG2188	Transcriptional regulator
HCU65_04075	COG0778	Nitroreductase
HCU65_04080	COG0737	Belongs to the 5'-nucleotidase family
HCU65_04085	COG0693	protein deglycase activity
HCU65_04090	COG1609	Transcriptional regulator
HCU65_04095	COG2814	Major facilitator Superfamily
HCU65_04100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCU65_04110	COG2814	Major facilitator Superfamily
HCU65_04115	COG4840	Belongs to the UPF0435 family
HCU65_04120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCU65_04125	COG4980	gas vesicle protein
HCU65_04130	COG1295	ribonuclease BN
HCU65_04135	COG0477	Major facilitator Superfamily
HCU65_04140	COG0387	Pfam Sodium calcium exchanger
HCU65_04150	COG0668	transmembrane transport
HCU65_04155	COG0535	radical SAM domain protein
HCU65_04165	COG0726	polysaccharide deacetylase
HCU65_04170	COG2084	Dehydrogenase
HCU65_04180	COG0598	Magnesium transport protein CorA
HCU65_04185	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HCU65_04195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCU65_04200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCU65_04205	COG4637	Psort location Cytoplasmic, score
HCU65_04210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCU65_04215	COG0022	dehydrogenase e1 component
HCU65_04220	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCU65_04225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCU65_04230	COG3284	Transcriptional regulator
HCU65_04240	COG1742	UPF0060 membrane protein
HCU65_04260	COG4842	Belongs to the WXG100 family
HCU65_04265	COG1486	melibiose metabolic process
HCU65_04270	COG1737	Transcriptional regulator
HCU65_04275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU65_04275	COG1263	PTS System
HCU65_04280	COG5434	Belongs to the glycosyl hydrolase 28 family
HCU65_04285	COG1132	(ABC) transporter
HCU65_04290	COG1132	(ABC) transporter
HCU65_04295	COG2259	Doxx family
HCU65_04300	COG2514	catechol 2,3-dioxygenase activity
HCU65_04310	COG4585	Histidine kinase
HCU65_04315	COG2197	response regulator
HCU65_04320	COG1131	(ABC) transporter
HCU65_04325	COG1511	domain protein
HCU65_04325	COG0842	Transport permease protein
HCU65_04330	COG0842	Transport permease protein
HCU65_04335	COG1695	Transcriptional regulator
HCU65_04340	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HCU65_04345	COG2732	(Barnase) inhibitor
HCU65_04350	COG0604	alcohol dehydrogenase
HCU65_04355	COG2318	DinB family
HCU65_04360	COG2814	Major facilitator Superfamily
HCU65_04365	COG1846	Transcriptional regulator
HCU65_04370	COG0392	lysyltransferase activity
HCU65_04370	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HCU65_04375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCU65_04380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU65_04385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU65_04390	COG0384	phenazine biosynthesis protein PhzF
HCU65_04395	COG0778	Nitroreductase
HCU65_04410	COG1090	epimerase
HCU65_04415	COG2137	regulation of response to DNA damage stimulus
HCU65_04425	COG2814	Major facilitator Superfamily
HCU65_04440	COG3103	Sh3 type 3 domain protein
HCU65_04445	COG5658	integral membrane protein
HCU65_04450	COG0596	Alpha beta hydrolase
HCU65_04455	COG0463	Glycosyl transferase, family 2
HCU65_04460	COG4485	Bacterial membrane protein, YfhO
HCU65_04465	COG1988	membrane-bound metal-dependent
HCU65_04470	COG1194	a g-specific adenine glycosylase
HCU65_04480	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_04495	COG3557	Belongs to the UPF0374 family
HCU65_04500	COG1132	(ABC) transporter
HCU65_04505	COG4129	membrane
HCU65_04510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCU65_04515	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCU65_04520	COG0735	belongs to the Fur family
HCU65_04630	COG4974	Belongs to the 'phage' integrase family
HCU65_04670	COG1063	alcohol dehydrogenase
HCU65_04675	COG5577	PFAM Coat F domain
HCU65_04685	COG4326	sporulation control protein
HCU65_04690	COG3340	Belongs to the peptidase S51 family
HCU65_04695	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HCU65_04705	COG0753	catalase activity
HCU65_04710	COG1116	anion transmembrane transporter activity
HCU65_04715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCU65_04720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCU65_04730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HCU65_04740	COG1476	TRANSCRIPTIONal
HCU65_04750	COG3382	B3 4 domain protein
HCU65_04755	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HCU65_04765	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HCU65_04770	COG0789	Transcriptional regulator
HCU65_04775	COG1664	Polymer-forming cytoskeletal
HCU65_04780	COG1664	Polymer-forming cytoskeletal
HCU65_04785	COG2766	serine protein kinase
HCU65_04790	COG2718	Belongs to the UPF0229 family
HCU65_04795	COG1846	Transcriptional regulator
HCU65_04800	COG1566	PFAM secretion protein HlyD family protein
HCU65_04805	COG2814	Major facilitator Superfamily
HCU65_04810	COG0655	NAD(P)H dehydrogenase (quinone) activity
HCU65_04825	COG1725	Transcriptional regulator
HCU65_04830	COG1131	(ABC) transporter
HCU65_04835	COG1131	(ABC) transporter
HCU65_04840	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HCU65_04845	COG1278	Cold shock
HCU65_04855	COG1464	Belongs to the NlpA lipoprotein family
HCU65_04860	COG3706	GGDEF domain
HCU65_04865	COG1823	symporter activity
HCU65_04885	COG5577	PFAM Coat F domain
HCU65_04895	COG4085	toxin activity
HCU65_04895	COG1525	nuclease
HCU65_04895	COG0737	Belongs to the 5'-nucleotidase family
HCU65_04900	COG3764	Sortase (surface protein transpeptidase)
HCU65_04905	COG0564	pseudouridine synthase activity
HCU65_04915	COG0517	IMP dehydrogenase activity
HCU65_04920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCU65_04925	COG3153	acetyltransferase
HCU65_04925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCU65_04935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCU65_04940	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HCU65_04945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HCU65_04950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HCU65_04955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HCU65_04960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCU65_04965	COG2203	Gaf domain
HCU65_04965	COG4585	Histidine kinase
HCU65_04970	COG2197	response regulator
HCU65_04975	COG0431	NADPH-dependent FMN reductase
HCU65_04990	COG1388	LysM domain
HCU65_04990	COG0791	NLP P60 protein
HCU65_04995	COG1959	2 iron, 2 sulfur cluster binding
HCU65_05000	COG0668	transmembrane transport
HCU65_05005	COG2719	SpoVR family
HCU65_05010	COG1785	Belongs to the alkaline phosphatase family
HCU65_05015	COG0791	NLP P60 protein
HCU65_05015	COG1388	LysM domain
HCU65_05020	COG0583	DNA-binding transcription factor activity
HCU65_05025	COG0372	Belongs to the citrate synthase family
HCU65_05030	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_05035	COG0531	amino acid
HCU65_05040	COG0733	neurotransmitter:sodium symporter activity
HCU65_05050	COG0456	acetyltransferase
HCU65_05055	COG0833	amino acid
HCU65_05060	COG4187	Peptidase family M20/M25/M40
HCU65_05065	COG1012	belongs to the aldehyde dehydrogenase family
HCU65_05070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCU65_05085	COG1595	DNA-templated transcription, initiation
HCU65_05090	COG0667	Aldo Keto reductase
HCU65_05095	COG0204	Acyl-transferase
HCU65_05105	COG1253	flavin adenine dinucleotide binding
HCU65_05110	COG0789	Transcriptional regulator
HCU65_05115	COG1253	flavin adenine dinucleotide binding
HCU65_05120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCU65_05125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCU65_05130	COG0584	glycerophosphoryl diester phosphodiesterase
HCU65_05140	COG0668	transmembrane transport
HCU65_05145	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HCU65_05150	COG0726	polysaccharide deacetylase
HCU65_05155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCU65_05160	COG1757	Na H antiporter
HCU65_05165	COG0589	response to stress
HCU65_05170	COG1132	(ABC) transporter
HCU65_05175	COG1132	(ABC) transporter
HCU65_05180	COG0702	epimerase
HCU65_05200	COG0189	ligase activity
HCU65_05205	COG0189	ligase activity
HCU65_05210	COG4399	Belongs to the UPF0754 family
HCU65_05220	COG4335	DNA alkylation repair
HCU65_05225	COG0561	phosphatase activity
HCU65_05230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCU65_05240	COG0475	glutathione-regulated potassium exporter activity
HCU65_05245	COG0490	domain, Protein
HCU65_05255	COG1024	Enoyl-CoA hydratase
HCU65_05265	COG4152	abc transporter atp-binding protein
HCU65_05270	COG1668	transmembrane transport
HCU65_05275	COG0420	3'-5' exonuclease activity
HCU65_05280	COG4717	serine-type aminopeptidase activity
HCU65_05285	COG3481	metal-dependent phosphohydrolase, HD sub domain
HCU65_05295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCU65_05330	COG4980	gas vesicle protein
HCU65_05345	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HCU65_05350	COG0537	adenosine 5'-monophosphoramidase activity
HCU65_05355	COG1131	(ABC) transporter
HCU65_05360	COG4473	ABC transporter
HCU65_05370	COG1473	amidohydrolase
HCU65_05375	COG3069	C4-dicarboxylate transmembrane transporter activity
HCU65_05380	COG2329	Antibiotic biosynthesis monooxygenase
HCU65_05385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCU65_05390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HCU65_05395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCU65_05400	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HCU65_05405	COG1309	transcriptional regulator
HCU65_05410	COG1511	domain protein
HCU65_05415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCU65_05425	COG1363	Peptidase, m42
HCU65_05430	COG1301	dicarboxylic acid transport
HCU65_05440	COG1234	tRNA 3'-trailer cleavage
HCU65_05445	COG0095	Lipoate-protein ligase
HCU65_05450	COG0702	epimerase
HCU65_05455	COG0318	PFAM AMP-dependent synthetase and ligase
HCU65_05465	COG0501	Belongs to the peptidase M48B family
HCU65_05470	COG1404	Belongs to the peptidase S8 family
HCU65_05475	COG0456	acetyltransferase
HCU65_05480	COG0604	alcohol dehydrogenase
HCU65_05485	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HCU65_05490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU65_05495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU65_05500	COG0406	alpha-ribazole phosphatase activity
HCU65_05505	COG0183	Belongs to the thiolase family
HCU65_05510	COG1960	acyl-CoA dehydrogenase activity
HCU65_05520	COG1012	belongs to the aldehyde dehydrogenase family
HCU65_05525	COG1024	Enoyl-CoA hydratase
HCU65_05535	COG0840	transmembrane signaling receptor activity
HCU65_05540	COG0723	plastoquinol--plastocyanin reductase activity
HCU65_05540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCU65_05545	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_05555	COG4903	ComK protein
HCU65_05565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCU65_05580	COG0398	Pfam SNARE associated Golgi protein
HCU65_05585	COG0681	Belongs to the peptidase S26 family
HCU65_05590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCU65_05595	COG1846	Transcriptional regulator
HCU65_05600	COG3180	Ammonia monooxygenase
HCU65_05610	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HCU65_05615	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HCU65_05620	COG1074	ATP-dependent DNA helicase activity
HCU65_05625	COG0420	3'-5' exonuclease activity
HCU65_05630	COG0419	ATPase involved in DNA repair
HCU65_05635	COG1403	HNH endonuclease
HCU65_05670	COG2311	Membrane
HCU65_05680	COG5337	Spore coat protein CotH
HCU65_05685	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCU65_05695	COG1404	Belongs to the peptidase S8 family
HCU65_05705	COG0367	asparagine synthase
HCU65_05710	COG1562	ergosterol biosynthetic process
HCU65_05715	COG0534	Mate efflux family protein
HCU65_05720	COG2207	Transcriptional regulator
HCU65_05720	COG1917	Cupin 2, conserved barrel domain protein
HCU65_05725	COG0109	protoheme IX farnesyltransferase activity
HCU65_05730	COG1609	Transcriptional regulator
HCU65_05735	COG0673	inositol 2-dehydrogenase activity
HCU65_05740	COG2318	DinB family
HCU65_05745	COG1279	arginine transmembrane transporter activity
HCU65_05750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCU65_05755	COG1357	PFAM Pentapeptide repeats (8 copies)
HCU65_05760	COG2267	carboxylic ester hydrolase activity
HCU65_05765	COG0529	Catalyzes the synthesis of activated sulfate
HCU65_05770	COG2046	Belongs to the sulfate adenylyltransferase family
HCU65_05775	COG0175	sulfate reduction
HCU65_05780	COG2045	Belongs to the ComB family
HCU65_05785	COG1809	phosphosulfolactate synthase activity
HCU65_05790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCU65_05795	COG4948	Mandelate Racemase Muconate Lactonizing
HCU65_05800	COG2814	Major facilitator Superfamily
HCU65_05815	COG2153	protein acetylation
HCU65_05820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HCU65_05820	COG0646	methionine synthase
HCU65_05830	COG2996	Protein conserved in bacteria
HCU65_05845	COG1307	EDD domain protein, DegV family
HCU65_05850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCU65_05870	COG0561	phosphatase activity
HCU65_05875	COG1073	alpha beta
HCU65_05880	COG2151	metal-sulfur cluster biosynthetic enzyme
HCU65_05890	COG0277	FAD linked oxidase domain protein
HCU65_05895	COG2271	Major facilitator Superfamily
HCU65_05900	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HCU65_05905	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HCU65_05915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCU65_05920	COG0505	Belongs to the CarA family
HCU65_05925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCU65_05930	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HCU65_05945	COG2267	carboxylic ester hydrolase activity
HCU65_05955	COG1744	ABC transporter substrate-binding protein PnrA-like
HCU65_05970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCU65_05975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCU65_05980	COG5504	Zn-dependent protease
HCU65_05985	COG0444	Belongs to the ABC transporter superfamily
HCU65_05990	COG4608	Belongs to the ABC transporter superfamily
HCU65_06000	COG0601	transmembrane transport
HCU65_06005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCU65_06015	COG0180	Tryptophanyl-tRNA synthetase
HCU65_06020	COG4166	transmembrane transport
HCU65_06025	COG0601	transmembrane transport
HCU65_06030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCU65_06035	COG0444	Belongs to the ABC transporter superfamily
HCU65_06040	COG4608	Belongs to the ABC transporter superfamily
HCU65_06055	COG0456	acetyltransferase
HCU65_06060	COG1393	Belongs to the ArsC family
HCU65_06065	COG0861	Integral membrane protein TerC family
HCU65_06070	COG4862	establishment of competence for transformation
HCU65_06075	COG4469	Competence protein
HCU65_06080	COG1164	Oligoendopeptidase f
HCU65_06090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HCU65_06095	COG2346	COG2346, Truncated hemoglobins
HCU65_06100	COG0741	lytic transglycosylase activity
HCU65_06105	COG4116	CYTH
HCU65_06115	COG2357	RelA SpoT domain protein
HCU65_06120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCU65_06125	COG0564	pseudouridine synthase activity
HCU65_06135	COG0569	domain protein
HCU65_06135	COG0475	glutathione-regulated potassium exporter activity
HCU65_06140	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HCU65_06145	COG0352	thiamine-phosphate diphosphorylase activity
HCU65_06150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCU65_06155	COG2104	thiamine diphosphate biosynthetic process
HCU65_06160	COG2022	thiamine diphosphate biosynthetic process
HCU65_06165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCU65_06170	COG0351	phosphomethylpyrimidine kinase
HCU65_06175	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HCU65_06230	COG0210	DNA helicase
HCU65_06240	COG2153	protein acetylation
HCU65_06250	COG2382	esterase
HCU65_06255	COG0626	cystathionine gamma-synthase activity
HCU65_06260	COG0626	cystathionine gamma-synthase activity
HCU65_06265	COG5505	Protein of unknown function (DUF819)
HCU65_06330	COG3209	COG3209 Rhs family protein
HCU65_06335	COG1285	pathogenesis
HCU65_06355	COG0726	polysaccharide deacetylase
HCU65_06365	COG2205	protein histidine kinase activity
HCU65_06375	COG3383	formate dehydrogenase (NAD+) activity
HCU65_06380	COG2427	Protein of unknown function (DUF1641)
HCU65_06390	COG1051	belongs to the nudix hydrolase family
HCU65_06400	COG2124	cytochrome p450
HCU65_06405	COG1819	glycosyl
HCU65_06425	COG1587	Uroporphyrinogen-III synthase
HCU65_06435	COG0390	transport system, permease component
HCU65_06440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCU65_06450	COG4297	protein containing double-stranded beta helix domain
HCU65_06460	COG1252	NADH dehydrogenase
HCU65_06465	COG1904	glucuronate isomerase
HCU65_06470	COG2211	Major facilitator Superfamily
HCU65_06475	COG1609	Transcriptional regulator
HCU65_06480	COG0246	Mannitol dehydrogenase
HCU65_06485	COG2721	sulfolactate sulfo-lyase activity
HCU65_06490	COG0730	response to heat
HCU65_06495	COG2318	DinB family
HCU65_06500	COG0457	Tetratricopeptide repeat
HCU65_06510	COG5632	N-Acetylmuramoyl-L-alanine amidase
HCU65_06510	COG3409	Peptidoglycan-binding domain 1 protein
HCU65_06510	COG1388	LysM domain
HCU65_06520	COG4195	phage-related replication protein
HCU65_06525	COG2856	Zn peptidase
HCU65_06530	COG1396	sequence-specific DNA binding
HCU65_06540	COG1522	sequence-specific DNA binding
HCU65_06545	COG1484	DNA-dependent DNA replication
HCU65_06565	COG1595	DNA-templated transcription, initiation
HCU65_06570	COG3728	DNA packaging
HCU65_06570	COG5484	DNA packaging
HCU65_06575	COG1783	phage Terminase large subunit
HCU65_06580	COG5518	Phage portal protein
HCU65_06585	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HCU65_06590	COG4653	Phage capsid family
HCU65_06640	COG5412	phage tail tape measure protein
HCU65_06640	COG3953	SLT domain
HCU65_06645	COG1652	LysM domain
HCU65_06650	COG4193	domain, Protein
HCU65_06665	COG3628	GPW Gp25 family protein
HCU65_06670	COG3299	homolog of phage Mu protein gp47
HCU65_06675	COG3778	Protein conserved in bacteria
HCU65_06715	COG3409	Peptidoglycan-binding domain 1 protein
HCU65_06715	COG5632	N-Acetylmuramoyl-L-alanine amidase
HCU65_06735	COG0306	phosphate transporter
HCU65_06740	COG1392	Phosphate transport regulator
HCU65_06745	COG0531	amino acid
HCU65_06750	COG0346	lactoylglutathione lyase activity
HCU65_06755	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HCU65_06760	COG0463	Glycosyl transferase, family 2
HCU65_06770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCU65_06775	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCU65_06780	COG2362	D-Aminopeptidase
HCU65_06785	COG0601	transmembrane transport
HCU65_06790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCU65_06795	COG0444	Belongs to the ABC transporter superfamily
HCU65_06800	COG4166	transmembrane transport
HCU65_06805	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCU65_06810	COG4948	Mandelate Racemase Muconate Lactonizing
HCU65_06815	COG0791	NLP P60 protein
HCU65_06820	COG4608	Belongs to the ABC transporter superfamily
HCU65_06825	COG2706	6-phosphogluconolactonase activity
HCU65_06830	COG1834	amidinotransferase
HCU65_06835	COG1607	acyl-coa hydrolase
HCU65_06840	COG2323	membrane
HCU65_06845	COG1695	Transcriptional regulator
HCU65_06860	COG2318	DinB family
HCU65_06865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCU65_06870	COG2076	Multidrug Resistance protein
HCU65_06875	COG2076	Multidrug Resistance protein
HCU65_06880	COG0788	formyltetrahydrofolate deformylase activity
HCU65_06885	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCU65_06890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HCU65_06895	COG1764	response to oxidative stress
HCU65_06900	COG1846	Transcriptional regulator
HCU65_06905	COG1764	response to oxidative stress
HCU65_06920	COG0463	Glycosyl transferase, family 2
HCU65_06920	COG0457	Tetratricopeptide repeat
HCU65_06930	COG0590	tRNA wobble adenosine to inosine editing
HCU65_06940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCU65_06945	COG1404	Belongs to the peptidase S8 family
HCU65_06950	COG1366	Belongs to the anti-sigma-factor antagonist family
HCU65_06955	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HCU65_06960	COG1122	ATPase activity
HCU65_06965	COG4721	ABC-type cobalt transport system, permease component
HCU65_06975	COG0745	RESPONSE REGULATOR receiver
HCU65_06980	COG3850	Histidine kinase
HCU65_06980	COG5002	protein histidine kinase activity
HCU65_06985	COG3212	peptidase
HCU65_06990	COG3212	peptidase
HCU65_07000	COG2239	Acts as a magnesium transporter
HCU65_07005	COG0789	Transcriptional regulator
HCU65_07020	COG1846	Transcriptional regulator
HCU65_07025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCU65_07030	COG0726	polysaccharide deacetylase
HCU65_07035	COG1408	metallophosphoesterase
HCU65_07050	COG0463	Glycosyl transferase, family 2
HCU65_07055	COG1793	dna ligase
HCU65_07055	COG3285	dna ligase
HCU65_07060	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HCU65_07070	COG3300	MHYT domain
HCU65_07070	COG5001	Diguanylate cyclase
HCU65_07075	COG0586	Pfam SNARE associated Golgi protein
HCU65_07080	COG0861	Integral membrane protein TerC family
HCU65_07085	COG1191	sigma factor activity
HCU65_07105	COG0501	Belongs to the peptidase M48B family
HCU65_07110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCU65_07115	COG2323	membrane
HCU65_07130	COG3594	Acyltransferase
HCU65_07135	COG5002	protein histidine kinase activity
HCU65_07140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCU65_07150	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HCU65_07155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCU65_07160	COG0436	Aminotransferase
HCU65_07165	COG1850	ribulose-bisphosphate carboxylase activity
HCU65_07175	COG0235	Class ii aldolase
HCU65_07180	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HCU65_07185	COG3339	Conserved Protein
HCU65_07200	COG3852	Histidine kinase
HCU65_07205	COG1846	Transcriptional regulator
HCU65_07210	COG1360	Flagellar Motor Protein
HCU65_07215	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HCU65_07220	COG0542	response to heat
HCU65_07225	COG3949	Membrane
HCU65_07240	COG0720	synthase
HCU65_07245	COG0602	queuosine metabolic process
HCU65_07250	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HCU65_07380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCU65_07380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCU65_07410	COG1780	Probably involved in ribonucleotide reductase function
HCU65_07420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCU65_07430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCU65_07445	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HCU65_07450	COG1388	LysM domain
HCU65_07450	COG3584	3D domain protein
HCU65_07525	COG5434	Belongs to the glycosyl hydrolase 28 family
HCU65_07525	COG3420	alginic acid biosynthetic process
HCU65_07530	COG4195	phage-related replication protein
HCU65_07540	COG1216	Glycosyl transferase, family 2
HCU65_07560	COG0582	viral genome integration into host DNA
HCU65_07650	COG1705	Flagellar rod assembly protein muramidase FlgJ
HCU65_07685	COG5632	N-Acetylmuramoyl-L-alanine amidase
HCU65_07685	COG3409	Peptidoglycan-binding domain 1 protein
HCU65_07685	COG1388	LysM domain
HCU65_07710	COG1674	ftsk spoiiie
HCU65_07730	COG0582	viral genome integration into host DNA
HCU65_07740	COG1366	Belongs to the anti-sigma-factor antagonist family
HCU65_07750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCU65_07755	COG4873	Protein conserved in bacteria
HCU65_07765	COG3773	Cell wall hydrolase
HCU65_07770	COG2244	polysaccharide biosynthetic process
HCU65_07775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCU65_07780	COG2217	Heavy metal translocating P-type atpase
HCU65_07790	COG0006	proline dipeptidase activity
HCU65_07795	COG1609	Transcriptional regulator
HCU65_07800	COG3711	transcriptional antiterminator
HCU65_07805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU65_07805	COG2190	(PTS) system
HCU65_07805	COG1263	PTS System
HCU65_07810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU65_07815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCU65_07825	COG1533	DNA photolyase activity
HCU65_07830	COG0456	acetyltransferase
HCU65_07835	COG0840	transmembrane signaling receptor activity
HCU65_07840	COG2084	Dehydrogenase
HCU65_07845	COG2340	Cysteine-rich secretory protein family
HCU65_07850	COG0768	penicillin binding
HCU65_07855	COG4191	Histidine kinase
HCU65_07860	COG0436	Aminotransferase
HCU65_07870	COG0784	Response regulator, receiver
HCU65_07870	COG0835	chemotaxis
HCU65_07880	COG2814	Major facilitator Superfamily
HCU65_07885	COG1376	ErfK ybiS ycfS ynhG family protein
HCU65_07890	COG1408	metallophosphoesterase
HCU65_07895	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_07900	COG2200	EAL domain
HCU65_07905	COG3546	catalase activity
HCU65_07910	COG4703	Protein of unknown function (DUF1797)
HCU65_07915	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HCU65_07925	COG0517	IMP dehydrogenase activity
HCU65_07930	COG0583	DNA-binding transcription factor activity
HCU65_07935	COG0716	FMN binding
HCU65_07945	COG0716	FMN binding
HCU65_07950	COG2171	N-acyltransferase activity
HCU65_07955	COG1473	amidohydrolase
HCU65_07965	COG0668	transmembrane transport
HCU65_07970	COG0450	alkyl hydroperoxide reductase
HCU65_07975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCU65_07990	COG0746	molybdenum cofactor guanylyltransferase activity
HCU65_07995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCU65_08000	COG0303	'Molybdopterin
HCU65_08005	COG1763	Mo-molybdopterin cofactor biosynthetic process
HCU65_08010	COG0314	molybdopterin synthase activity
HCU65_08015	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HCU65_08025	COG1132	(ABC) transporter
HCU65_08035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCU65_08040	COG1136	(ABC) transporter
HCU65_08045	COG0577	efflux transmembrane transporter activity
HCU65_08050	COG1349	DNA-binding transcription factor activity
HCU65_08055	COG1105	Belongs to the carbohydrate kinase PfkB family
HCU65_08060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCU65_08060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU65_08060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCU65_08065	COG0681	Belongs to the peptidase S26 family
HCU65_08075	COG0488	(ABC) transporter
HCU65_08080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCU65_08085	COG2309	aminopeptidase activity
HCU65_08095	COG1077	Cell shape determining protein MreB Mrl
HCU65_08100	COG2002	toxin-antitoxin pair type II binding
HCU65_08105	COG3852	Histidine kinase
HCU65_08110	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HCU65_08110	COG2105	PFAM AIG2 family protein
HCU65_08115	COG0569	domain protein
HCU65_08120	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HCU65_08125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCU65_08135	COG0561	phosphatase activity
HCU65_08140	COG0242	peptide deformylase activity
HCU65_08150	COG0497	DNA recombination
HCU65_08155	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCU65_08160	COG0022	dehydrogenase e1 component
HCU65_08165	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCU65_08170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCU65_08175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCU65_08190	COG1982	Orn Lys Arg decarboxylase major
HCU65_08195	COG4476	Belongs to the UPF0223 family
HCU65_08200	COG4493	Belongs to the UPF0637 family
HCU65_08210	COG0483	inositol monophosphate 1-phosphatase activity
HCU65_08220	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HCU65_08240	COG1595	DNA-templated transcription, initiation
HCU65_08260	COG1217	gtp-binding protein TYPA
HCU65_08270	COG4896	Protein conserved in bacteria
HCU65_08280	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HCU65_08285	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HCU65_08290	COG2066	Belongs to the glutaminase family
HCU65_08295	COG4838	Belongs to the UPF0358 family
HCU65_08300	COG0772	Belongs to the SEDS family
HCU65_08305	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HCU65_08310	COG1612	heme a metabolic process
HCU65_08320	COG2010	Cytochrome c
HCU65_08320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCU65_08325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCU65_08330	COG1845	cytochrome c oxidase, subunit III
HCU65_08335	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HCU65_08340	COG3336	cytochrome c oxidase
HCU65_08350	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HCU65_08355	COG2340	Cysteine-rich secretory protein family
HCU65_08375	COG3679	Belongs to the UPF0342 family
HCU65_08380	COG4471	UPF0298 protein
HCU65_08390	COG0742	ribosomal rna small subunit methyltransferase
HCU65_08395	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HCU65_08400	COG3314	Sporulation integral membrane protein YlbJ
HCU65_08405	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCU65_08410	COG3480	Lon protease (S16) C-terminal proteolytic domain
HCU65_08415	COG1323	Belongs to the UPF0348 family
HCU65_08420	COG1399	metal-binding, possibly nucleic acid-binding protein
HCU65_08440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCU65_08445	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HCU65_08450	COG2001	Belongs to the MraZ family
HCU65_08455	COG0275	rRNA processing
HCU65_08460	COG4839	cell division protein FtsL
HCU65_08465	COG0768	penicillin binding
HCU65_08470	COG0768	penicillin binding
HCU65_08475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCU65_08480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCU65_08485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HCU65_08490	COG0772	Belongs to the SEDS family
HCU65_08495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCU65_08500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HCU65_08505	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HCU65_08510	COG3879	Bacterial protein of unknown function (DUF881)
HCU65_08515	COG3879	Bacterial protein of unknown function (DUF881)
HCU65_08520	COG3856	small basic protein
HCU65_08525	COG0849	cell division
HCU65_08530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCU65_08535	COG1404	Belongs to the peptidase S8 family
HCU65_08535	COG4412	M6 family metalloprotease domain protein
HCU65_08545	COG1191	sigma factor activity
HCU65_08550	COG1191	sigma factor activity
HCU65_08555	COG1119	ATPase activity
HCU65_08560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCU65_08565	COG1873	PFAM PRC-barrel domain
HCU65_08570	COG1496	oxidoreductase activity
HCU65_08575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HCU65_08580	COG1799	cell septum assembly
HCU65_08585	COG0762	integral membrane protein
HCU65_08590	COG2302	S4 RNA-binding domain
HCU65_08595	COG3599	regulation of cell shape
HCU65_08600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HCU65_08605	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCU65_08610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HCU65_08615	COG0564	pseudouridine synthase activity
HCU65_08625	COG2233	PERMEase
HCU65_08630	COG0540	Belongs to the ATCase OTCase family
HCU65_08635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCU65_08640	COG0505	Belongs to the CarA family
HCU65_08645	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCU65_08650	COG0543	2 iron, 2 sulfur cluster binding
HCU65_08655	COG0167	dihydroorotate dehydrogenase activity
HCU65_08660	COG0284	orotidine-5'-phosphate decarboxylase activity
HCU65_08665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCU65_08670	COG0175	sulfate reduction
HCU65_08675	COG0306	phosphate transporter
HCU65_08680	COG2046	Belongs to the sulfate adenylyltransferase family
HCU65_08685	COG0529	Catalyzes the synthesis of activated sulfate
HCU65_08690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCU65_08695	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HCU65_08700	COG1648	precorrin-2 dehydrogenase activity
HCU65_08705	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HCU65_08710	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCU65_08715	COG1561	YicC-like family, N-terminal region
HCU65_08725	COG0194	GDP metabolic process
HCU65_08730	COG1758	RNA polymerase activity
HCU65_08735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCU65_08740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCU65_08745	COG0242	peptide deformylase activity
HCU65_08750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCU65_08755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HCU65_08755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCU65_08765	COG0631	protein serine/threonine phosphatase activity
HCU65_08770	COG0515	serine threonine protein kinase
HCU65_08770	COG2815	serine threonine protein kinase
HCU65_08775	COG1162	GTPase activity
HCU65_08780	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCU65_08785	COG1564	THIamine pyrophosphokinase
HCU65_08795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HCU65_08800	COG1302	Protein conserved in bacteria
HCU65_08805	COG1461	Dihydroxyacetone kinase
HCU65_08810	COG1760	l-serine dehydratase
HCU65_08815	COG1760	l-serine dehydratase
HCU65_08820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCU65_08825	COG2050	protein possibly involved in aromatic compounds catabolism
HCU65_08825	COG1349	DNA-binding transcription factor activity
HCU65_08835	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCU65_08840	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_08850	COG0571	ribonuclease III activity
HCU65_08855	COG1196	nuclear chromosome segregation
HCU65_08860	COG0552	protein localization to endoplasmic reticulum
HCU65_08865	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HCU65_08870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HCU65_08875	COG0228	four-way junction DNA binding
HCU65_08880	COG1837	Belongs to the UPF0109 family
HCU65_08890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HCU65_08895	COG0336	Belongs to the RNA methyltransferase TrmD family
HCU65_08905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HCU65_08910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HCU65_08920	COG2257	FlhB HrpN YscU SpaS Family
HCU65_08930	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HCU65_08935	COG0758	DNA mediated transformation
HCU65_08940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCU65_08945	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HCU65_08950	COG4974	Belongs to the 'phage' integrase family
HCU65_08955	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HCU65_08960	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HCU65_08970	COG1815	bacterial-type flagellum-dependent cell motility
HCU65_08975	COG1558	bacterial-type flagellum-dependent cell motility
HCU65_08980	COG1677	Flagellar hook-basal body complex protein FliE
HCU65_08985	COG1766	The M ring may be actively involved in energy transduction
HCU65_08990	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCU65_08995	COG1317	bacterial-type flagellum organization
HCU65_09000	COG1157	protein secretion by the type III secretion system
HCU65_09005	COG2882	bacterial-type flagellum organization
HCU65_09010	COG3334	PFAM MgtE intracellular
HCU65_09015	COG3144	bacterial-type flagellum assembly
HCU65_09020	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HCU65_09025	COG4786	Flagellar basal body rod
HCU65_09030	COG1582	Flagellar protein (FlbD)
HCU65_09035	COG1580	Controls the rotational direction of flagella during chemotaxis
HCU65_09040	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCU65_09045	COG1776	CheC inhibitor of MCP methylation
HCU65_09045	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCU65_09050	COG2201	protein-glutamate methylesterase activity
HCU65_09055	COG3190	flagellar
HCU65_09060	COG1338	Plays a role in the flagellum-specific transport system
HCU65_09065	COG1987	bacterial-type flagellum assembly
HCU65_09070	COG1684	flagellar biosynthetic protein fliR
HCU65_09075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HCU65_09080	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HCU65_09085	COG1419	protein localization to endoplasmic reticulum
HCU65_09090	COG0455	bacterial-type flagellum organization
HCU65_09095	COG2201	protein-glutamate methylesterase activity
HCU65_09100	COG0643	Histidine kinase
HCU65_09100	COG2198	Histidine kinase
HCU65_09105	COG0835	chemotaxis
HCU65_09110	COG1776	CheC inhibitor of MCP methylation
HCU65_09115	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HCU65_09120	COG1191	sigma factor activity
HCU65_09135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HCU65_09140	COG0528	UMP kinase activity
HCU65_09145	COG0233	cytoplasmic translational termination
HCU65_09150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCU65_09155	COG4589	Belongs to the CDS family
HCU65_09160	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HCU65_09165	COG0750	zinc metalloprotease
HCU65_09170	COG0442	prolyl-tRNA aminoacylation
HCU65_09175	COG2176	DNA-directed DNA polymerase activity
HCU65_09180	COG0779	Required for maturation of 30S ribosomal subunits
HCU65_09185	COG0195	Participates in both transcription termination and antitermination
HCU65_09190	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HCU65_09195	COG1358	cellular component organization or biogenesis
HCU65_09200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCU65_09205	COG1550	Protein conserved in bacteria
HCU65_09210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HCU65_09215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HCU65_09220	COG0196	riboflavin kinase activity
HCU65_09230	COG1185	polyribonucleotide nucleotidyltransferase activity
HCU65_09235	COG0726	polysaccharide deacetylase
HCU65_09240	COG0612	Peptidase, M16
HCU65_09245	COG1873	PFAM PRC-barrel domain
HCU65_09250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCU65_09255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCU65_09260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCU65_09265	COG0527	aspartate kinase activity
HCU65_09275	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCU65_09280	COG0740	serine-type endopeptidase activity
HCU65_09290	COG1674	ftsk spoiiie
HCU65_09290	COG4980	gas vesicle protein
HCU65_09295	COG2188	Transcriptional regulator
HCU65_09300	COG2814	Major facilitator Superfamily
HCU65_09305	COG0612	Peptidase, M16
HCU65_09310	COG0612	Peptidase, M16
HCU65_09315	COG0300	oxidoreductase activity
HCU65_09330	COG1426	Protein conserved in bacteria
HCU65_09335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HCU65_09340	COG1058	Belongs to the CinA family
HCU65_09340	COG1546	Belongs to the CinA family
HCU65_09345	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HCU65_09350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCU65_09360	COG1692	metallophosphoesterase
HCU65_09365	COG2359	stage V sporulation protein S
HCU65_09370	COG1063	alcohol dehydrogenase
HCU65_09375	COG0156	8-amino-7-oxononanoate synthase activity
HCU65_09390	COG4550	Control of competence regulator ComK, YlbF/YmcA
HCU65_09400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HCU65_09405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HCU65_09425	COG3226	Transcriptional regulator
HCU65_09430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCU65_09435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCU65_09440	COG3321	synthase
HCU65_09445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCU65_09445	COG2070	2-Nitropropane dioxygenase
HCU65_09450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCU65_09455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCU65_09460	COG3425	synthase
HCU65_09465	COG1024	Enoyl-CoA hydratase
HCU65_09470	COG1024	Enoyl-CoA hydratase
HCU65_09475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCU65_09475	COG0318	PFAM AMP-dependent synthetase and ligase
HCU65_09475	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_09475	COG3321	synthase
HCU65_09475	COG0300	oxidoreductase activity
HCU65_09480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCU65_09480	COG0300	oxidoreductase activity
HCU65_09480	COG4221	oxidoreductase activity
HCU65_09480	COG3321	synthase
HCU65_09485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCU65_09485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCU65_09485	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_09485	COG3321	synthase
HCU65_09485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCU65_09490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCU65_09490	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_09490	COG3321	synthase
HCU65_09490	COG4221	oxidoreductase activity
HCU65_09495	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HCU65_09495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCU65_09495	COG3321	synthase
HCU65_09495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCU65_09500	COG2124	cytochrome p450
HCU65_09510	COG1404	Belongs to the peptidase S8 family
HCU65_09520	COG4195	phage-related replication protein
HCU65_09525	COG1764	response to oxidative stress
HCU65_09535	COG2076	Multidrug Resistance protein
HCU65_09555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HCU65_09580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCU65_09585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCU65_09590	COG4112	unkown
HCU65_09595	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCU65_09600	COG0464	growth
HCU65_09605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCU65_09610	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HCU65_09615	COG0789	Transcriptional regulator
HCU65_09620	COG0174	glutamine synthetase
HCU65_09635	COG0456	acetyltransferase
HCU65_09665	COG0346	lactoylglutathione lyase activity
HCU65_09685	COG2273	Hydrolase Family 16
HCU65_09710	COG3391	amine dehydrogenase activity
HCU65_09720	COG0657	acetylesterase activity
HCU65_09740	COG2318	DinB family
HCU65_09750	COG2367	Beta-lactamase
HCU65_09760	COG4641	Protein conserved in bacteria
HCU65_09760	COG1388	LysM domain
HCU65_09765	COG1388	LysM domain
HCU65_09770	COG3858	chitin binding
HCU65_09775	COG2720	vancomycin resistance protein
HCU65_09780	COG5553	Cysteine dioxygenase type I
HCU65_09795	COG3409	Peptidoglycan-binding domain 1 protein
HCU65_09810	COG0456	acetyltransferase
HCU65_09815	COG4978	Transcriptional regulator
HCU65_09815	COG0789	Transcriptional regulator
HCU65_09820	COG2030	dehydratase
HCU65_09835	COG2135	peptidase activity
HCU65_09855	COG1131	(ABC) transporter
HCU65_09900	COG4195	phage-related replication protein
HCU65_09905	COG3619	membrane
HCU65_09925	COG4195	phage-related replication protein
HCU65_09950	COG5577	PFAM Coat F domain
HCU65_09960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HCU65_09965	COG1388	LysM domain
HCU65_09970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCU65_09975	COG4224	UPF0291 protein
HCU65_09980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HCU65_09990	COG3763	UPF0154 protein
HCU65_10000	COG0785	Cytochrome C biogenesis protein
HCU65_10005	COG2201	protein-glutamate methylesterase activity
HCU65_10010	COG4846	Membrane protein involved in cytochrome C biogenesis
HCU65_10020	COG0071	Belongs to the small heat shock protein (HSP20) family
HCU65_10035	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HCU65_10040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCU65_10060	COG0824	Thioesterase
HCU65_10070	COG4841	protein insertion into membrane
HCU65_10075	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HCU65_10080	COG1832	CoA-binding protein
HCU65_10085	COG0187	DNA topoisomerase II activity
HCU65_10090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCU65_10100	COG1115	amino acid carrier protein
HCU65_10120	COG5520	Belongs to the glycosyl hydrolase 30 family
HCU65_10125	COG3507	Belongs to the glycosyl hydrolase 43 family
HCU65_10140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCU65_10145	COG0586	Pfam SNARE associated Golgi protein
HCU65_10150	COG2404	hydrolase activity, acting on ester bonds
HCU65_10155	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCU65_10160	COG1024	Enoyl-CoA hydratase
HCU65_10165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCU65_10170	COG0511	ligase activity, forming carbon-carbon bonds
HCU65_10175	COG0439	Biotin carboxylase
HCU65_10180	COG0318	PFAM AMP-dependent synthetase and ligase
HCU65_10185	COG1960	acyl-CoA dehydrogenase activity
HCU65_10190	COG1649	PFAM Uncharacterised BCR, COG1649
HCU65_10200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCU65_10200	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HCU65_10205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCU65_10210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCU65_10215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCU65_10220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCU65_10225	COG1017	nitric oxide dioxygenase activity
HCU65_10225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCU65_10230	COG2027	D-alanyl-D-alanine carboxypeptidase
HCU65_10235	COG2017	converts alpha-aldose to the beta-anomer
HCU65_10245	COG2207	Transcriptional regulator
HCU65_10245	COG3708	Transcriptional regulator
HCU65_10255	COG0457	Tetratricopeptide repeat
HCU65_10270	COG1388	LysM domain
HCU65_10270	COG5632	N-Acetylmuramoyl-L-alanine amidase
HCU65_10270	COG3409	Peptidoglycan-binding domain 1 protein
HCU65_10285	COG0582	viral genome integration into host DNA
HCU65_10290	COG0166	Belongs to the GPI family
HCU65_10295	COG0405	Gamma-glutamyltransferase
HCU65_10305	COG0604	alcohol dehydrogenase
HCU65_10315	COG0493	'glutamate synthase
HCU65_10320	COG0067	glutamate synthase
HCU65_10320	COG0069	glutamate synthase activity
HCU65_10320	COG0070	glutamate synthase
HCU65_10325	COG0583	DNA-binding transcription factor activity
HCU65_10330	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCU65_10365	COG0693	protein deglycase activity
HCU65_10375	COG0300	oxidoreductase activity
HCU65_10380	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HCU65_10385	COG2318	DinB family
HCU65_10390	COG2814	Major facilitator Superfamily
HCU65_10395	COG1070	Carbohydrate kinase
HCU65_10455	COG3655	Transcriptional regulator
HCU65_10460	COG1793	dna ligase
HCU65_10570	COG5444	nuclease activity
HCU65_10575	COG1136	(ABC) transporter
HCU65_10600	COG4282	regulation of fungal-type cell wall biogenesis
HCU65_10615	COG0582	viral genome integration into host DNA
HCU65_10620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCU65_10625	COG0243	molybdopterin cofactor binding
HCU65_10645	COG1309	transcriptional regulator
HCU65_10660	COG2211	Major facilitator Superfamily
HCU65_10670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCU65_10675	COG0662	Cupin 2, conserved barrel domain protein
HCU65_10675	COG2207	Transcriptional regulator
HCU65_10685	COG1309	transcriptional regulator
HCU65_10690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCU65_10695	COG3708	Transcriptional regulator
HCU65_10700	COG2378	regulation of single-species biofilm formation
HCU65_10710	COG0640	Transcriptional regulator
HCU65_10715	COG0741	lytic transglycosylase activity
HCU65_10720	COG2322	membrane
HCU65_10735	COG3239	Fatty acid desaturase
HCU65_10740	COG4585	Histidine kinase
HCU65_10745	COG2197	response regulator
HCU65_10750	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCU65_10755	COG1388	LysM domain
HCU65_10755	COG3584	3D domain protein
HCU65_10760	COG0514	ATP-dependent DNA helicase (RecQ)
HCU65_10770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HCU65_10775	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCU65_10795	COG1012	belongs to the aldehyde dehydrogenase family
HCU65_10800	COG1657	PFAM Prenyltransferase squalene oxidase
HCU65_10805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCU65_10810	COG0733	neurotransmitter:sodium symporter activity
HCU65_10815	COG0385	Bile acid
HCU65_10820	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCU65_10825	COG0567	Dehydrogenase, E1 component
HCU65_10830	COG4548	von Willebrand factor, type A
HCU65_10835	COG0714	Associated with various cellular activities
HCU65_10840	COG2032	superoxide dismutase activity
HCU65_10845	COG0791	NLP P60 protein
HCU65_10845	COG1388	LysM domain
HCU65_10850	COG1819	glycosyl
HCU65_10855	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HCU65_10860	COG0534	Mate efflux family protein
HCU65_10865	COG1366	Belongs to the anti-sigma-factor antagonist family
HCU65_10875	COG1070	Carbohydrate kinase
HCU65_10890	COG3507	Belongs to the glycosyl hydrolase 43 family
HCU65_10895	COG2211	Major facilitator Superfamily
HCU65_10915	COG0726	polysaccharide deacetylase
HCU65_10920	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCU65_10925	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCU65_10935	COG2962	Rard protein
HCU65_10955	COG1733	regulation of RNA biosynthetic process
HCU65_10960	COG0778	Nitroreductase
HCU65_10965	COG0400	carboxylic ester hydrolase activity
HCU65_10970	COG0346	lactoylglutathione lyase activity
HCU65_10980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCU65_10985	COG3409	Peptidoglycan-binding domain 1 protein
HCU65_10985	COG0793	Belongs to the peptidase S41A family
HCU65_10990	COG2226	methyltransferase
HCU65_11000	COG1876	peptidase activity
HCU65_11005	COG0813	purine-nucleoside phosphorylase activity
HCU65_11020	COG0671	phosphoesterase, PA-phosphatase related
HCU65_11050	COG1509	lysine 2,3-aminomutase activity
HCU65_11055	COG0456	acetyltransferase
HCU65_11060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCU65_11065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HCU65_11070	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HCU65_11075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCU65_11085	COG0456	acetyltransferase
HCU65_11090	COG0463	Glycosyl transferase, family 2
HCU65_11105	COG4641	Protein conserved in bacteria
HCU65_11110	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HCU65_11115	COG0582	viral genome integration into host DNA
HCU65_11120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCU65_11140	COG0366	Alpha amylase catalytic
HCU65_11145	COG3397	chitin binding
HCU65_11155	COG3655	Transcriptional regulator
HCU65_11160	COG3739	integral membrane protein
HCU65_11170	COG2207	Transcriptional regulator
HCU65_11170	COG3708	Transcriptional regulator
HCU65_11195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCU65_11200	COG1846	Transcriptional regulator
HCU65_11205	COG0534	Mate efflux family protein
HCU65_11215	COG4698	Protein conserved in bacteria
HCU65_11220	COG2755	lipolytic protein G-D-S-L family
HCU65_11225	COG1999	signal sequence binding
HCU65_11235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCU65_11240	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HCU65_11245	COG1272	protein, Hemolysin III
HCU65_11250	COG0204	Acyl-transferase
HCU65_11255	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HCU65_11265	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HCU65_11275	COG2136	Putative SAM-dependent methyltransferase
HCU65_11275	COG2521	methyltransferase
HCU65_11290	COG1413	lyase activity
HCU65_11295	COG1418	mRNA catabolic process
HCU65_11300	COG0386	Belongs to the glutathione peroxidase family
HCU65_11305	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HCU65_11310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCU65_11315	COG1278	Cold shock
HCU65_11335	COG0328	RNA-DNA hybrid ribonuclease activity
HCU65_11340	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HCU65_11345	COG0328	RNA-DNA hybrid ribonuclease activity
HCU65_11355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCU65_11370	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCU65_11380	COG1755	Isoprenylcysteine carboxyl methyltransferase
HCU65_11385	COG3424	synthase
HCU65_11390	COG2233	PERMEase
HCU65_11395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCU65_11400	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HCU65_11410	COG0800	Aldolase
HCU65_11415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCU65_11420	COG1609	Transcriptional regulator
HCU65_11425	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HCU65_11430	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_11435	COG1199	ATP-dependent helicase activity
HCU65_11450	COG0116	Belongs to the methyltransferase superfamily
HCU65_11480	COG3359	exonuclease
HCU65_11485	COG1111	helicase
HCU65_11485	COG1205	dead DEAH box helicase
HCU65_11490	COG2190	(PTS) system
HCU65_11495	COG0071	Belongs to the small heat shock protein (HSP20) family
HCU65_11530	COG3331	DNA recombination
HCU65_11535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCU65_11535	COG4499	WXG100 protein secretion system (Wss), protein YukC
HCU65_11545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HCU65_11550	COG3935	DnaD domain protein
HCU65_11555	COG0017	Asparaginyl-tRNA synthetase
HCU65_11560	COG0436	Aminotransferase
HCU65_11565	COG5353	protein conserved in bacteria
HCU65_11575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HCU65_11575	COG1199	ATP-dependent helicase activity
HCU65_11580	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HCU65_11585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HCU65_11590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HCU65_11595	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HCU65_11595	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HCU65_11600	COG0617	tRNA 3'-terminal CCA addition
HCU65_11605	COG0438	transferase activity, transferring glycosyl groups
HCU65_11610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCU65_11625	COG1694	Mazg nucleotide pyrophosphohydrolase
HCU65_11630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCU65_11635	COG2140	Oxalate decarboxylase
HCU65_11645	COG4347	Protein of unknown function (DUF1405)
HCU65_11650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCU65_11650	COG2010	Cytochrome c
HCU65_11655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCU65_11660	COG0723	plastoquinol--plastocyanin reductase activity
HCU65_11670	COG5582	Belongs to the UPF0302 family
HCU65_11675	COG0457	Tetratricopeptide repeat
HCU65_11680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HCU65_11685	COG0287	Prephenate dehydrogenase
HCU65_11690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCU65_11695	COG0159	tryptophan synthase activity
HCU65_11715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCU65_11720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCU65_11725	COG4401	Chorismate mutase type I
HCU65_11730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HCU65_11740	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HCU65_11745	COG0105	UTP biosynthetic process
HCU65_11750	COG0142	geranyltranstransferase activity
HCU65_11760	COG0142	geranyltranstransferase activity
HCU65_11770	COG0302	gtp cyclohydrolase
HCU65_11775	COG0776	regulation of translation
HCU65_11780	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCU65_11795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HCU65_11800	COG1160	GTP binding
HCU65_11825	COG1304	FMN binding
HCU65_11830	COG0539	negative regulation of cytoplasmic translation
HCU65_11835	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HCU65_11845	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HCU65_11850	COG2959	enzyme of heme biosynthesis
HCU65_11855	COG3409	Peptidoglycan-binding domain 1 protein
HCU65_11855	COG3773	Cell wall hydrolase
HCU65_11860	COG2339	peptidase activity
HCU65_11865	COG0492	ferredoxin-NADP+ reductase activity
HCU65_11870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCU65_11875	COG4862	establishment of competence for transformation
HCU65_11880	COG1408	metallophosphoesterase
HCU65_11890	COG1388	LysM domain
HCU65_11895	COG1266	CAAX protease self-immunity
HCU65_11900	COG0514	ATP-dependent DNA helicase (RecQ)
HCU65_11905	COG4955	Helix-turn-helix domain
HCU65_11910	COG1141	Ferredoxin
HCU65_11915	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HCU65_11920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCU65_11925	COG0710	3-dehydroquinate dehydratase activity
HCU65_11935	COG1595	DNA-templated transcription, initiation
HCU65_11940	COG5002	protein histidine kinase activity
HCU65_11945	COG0745	RESPONSE REGULATOR receiver
HCU65_11950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCU65_11955	COG1333	cytochrome c biogenesis protein
HCU65_11960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCU65_11965	COG1187	pseudouridine synthase activity
HCU65_11970	COG0700	Nucleoside recognition
HCU65_11975	COG2715	membrane protein required for spore maturation
HCU65_11980	COG1686	Belongs to the peptidase S11 family
HCU65_11990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HCU65_11995	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HCU65_12005	COG1547	Domain of unknown function (DUF309)
HCU65_12010	COG0456	acetyltransferase
HCU65_12015	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HCU65_12020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCU65_12020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCU65_12025	COG0307	riboflavin synthase, alpha
HCU65_12030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCU65_12030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCU65_12040	COG0681	Belongs to the peptidase S26 family
HCU65_12045	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HCU65_12050	COG1278	Cold shock
HCU65_12055	COG0823	Involved in the tonB-independent uptake of proteins
HCU65_12065	COG3420	alginic acid biosynthetic process
HCU65_12075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCU65_12080	COG4086	secreted protein
HCU65_12085	COG0019	diaminopimelate decarboxylase activity
HCU65_12090	COG0697	spore germination
HCU65_12105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCU65_12125	COG1191	sigma factor activity
HCU65_12130	COG2172	sigma factor antagonist activity
HCU65_12135	COG1366	Belongs to the anti-sigma-factor antagonist family
HCU65_12140	COG1686	Belongs to the peptidase S11 family
HCU65_12145	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HCU65_12150	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HCU65_12155	COG4974	Belongs to the 'phage' integrase family
HCU65_12165	COG0735	belongs to the Fur family
HCU65_12170	COG1300	Membrane
HCU65_12180	COG0281	malic enzyme
HCU65_12185	COG1757	Na H antiporter
HCU65_12190	COG1027	Aspartate ammonia-lyase
HCU65_12195	COG0252	asparaginase activity
HCU65_12200	COG1396	sequence-specific DNA binding
HCU65_12205	COG1379	DNA repair
HCU65_12210	COG0494	nUDIX hydrolase
HCU65_12220	COG0667	Aldo Keto reductase
HCU65_12230	COG1073	alpha beta
HCU65_12240	COG4918	Iron-sulphur cluster biosynthesis
HCU65_12245	COG0456	acetyltransferase
HCU65_12245	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HCU65_12250	COG2329	Antibiotic biosynthesis monooxygenase
HCU65_12255	COG0456	acetyltransferase
HCU65_12265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCU65_12275	COG0628	permease
HCU65_12290	COG0346	lactoylglutathione lyase activity
HCU65_12295	COG1072	(Pantothenic acid kinase))
HCU65_12300	COG3048	D-serine ammonia-lyase activity
HCU65_12305	COG0300	oxidoreductase activity
HCU65_12310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCU65_12315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCU65_12320	COG4187	Peptidase family M20/M25/M40
HCU65_12325	COG1902	pentaerythritol trinitrate reductase activity
HCU65_12330	COG0596	Alpha beta hydrolase
HCU65_12340	COG1234	tRNA 3'-trailer cleavage
HCU65_12345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HCU65_12350	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HCU65_12355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCU65_12365	COG0706	membrane insertase activity
HCU65_12390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCU65_12395	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_12400	COG2986	histidine ammonia-lyase
HCU65_12410	COG0109	protoheme IX farnesyltransferase activity
HCU65_12420	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCU65_12425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCU65_12430	COG0346	lactoylglutathione lyase activity
HCU65_12440	COG1376	ErfK ybiS ycfS ynhG family protein
HCU65_12445	COG4129	membrane
HCU65_12450	COG1126	abc transporter atp-binding protein
HCU65_12455	COG0765	amino acid transport
HCU65_12460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCU65_12470	COG1597	lipid kinase activity
HCU65_12480	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCU65_12485	COG0022	dehydrogenase e1 component
HCU65_12490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCU65_12495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCU65_12500	COG3426	butyrate kinase activity
HCU65_12505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCU65_12510	COG0280	phosphate acetyltransferase
HCU65_12515	COG3290	protein histidine kinase activity
HCU65_12515	COG3829	transcription factor binding
HCU65_12525	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HCU65_12530	COG2079	MmgE PrpD family protein
HCU65_12535	COG0372	Belongs to the citrate synthase family
HCU65_12540	COG1960	acyl-CoA dehydrogenase activity
HCU65_12545	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCU65_12550	COG0183	Belongs to the thiolase family
HCU65_12555	COG0584	glycerophosphoryl diester phosphodiesterase
HCU65_12560	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCU65_12570	COG1902	pentaerythritol trinitrate reductase activity
HCU65_12580	COG0745	RESPONSE REGULATOR receiver
HCU65_12585	COG0750	zinc metalloprotease
HCU65_12590	COG0497	DNA recombination
HCU65_12595	COG1438	arginine binding
HCU65_12600	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HCU65_12605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HCU65_12610	COG0142	geranyltranstransferase activity
HCU65_12615	COG1722	exodeoxyribonuclease VII activity
HCU65_12620	COG1570	exodeoxyribonuclease VII activity
HCU65_12625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HCU65_12630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCU65_12635	COG1302	Protein conserved in bacteria
HCU65_12640	COG0439	Biotin carboxylase
HCU65_12645	COG0511	ligase activity, forming carbon-carbon bonds
HCU65_12685	COG3854	ATPases associated with a variety of cellular activities
HCU65_12695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HCU65_12700	COG0006	proline dipeptidase activity
HCU65_12705	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HCU65_12715	COG3872	metal-dependent enzyme
HCU65_12725	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCU65_12730	COG1321	iron dependent repressor
HCU65_12735	COG0095	Lipoate-protein ligase
HCU65_12740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCU65_12745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCU65_12750	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCU65_12755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HCU65_12760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCU65_12775	COG1396	sequence-specific DNA binding
HCU65_12785	COG0681	Belongs to the peptidase S26 family
HCU65_12810	COG4940	Competence protein ComGF
HCU65_12820	COG4970	Tfp pilus assembly protein FimT
HCU65_12825	COG4537	Required for transformation and DNA binding
HCU65_12830	COG1459	type II secretion system
HCU65_12835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HCU65_12840	COG0598	Magnesium transport protein CorA
HCU65_12845	COG1253	flavin adenine dinucleotide binding
HCU65_12850	COG1366	Belongs to the anti-sigma-factor antagonist family
HCU65_12860	COG1393	Belongs to the ArsC family
HCU65_12870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCU65_12880	COG0011	TIGRFAM Protein of
HCU65_12890	COG2866	Carboxypeptidase
HCU65_12895	COG1368	sulfuric ester hydrolase activity
HCU65_12900	COG1940	carbohydrate kinase activity
HCU65_12905	COG4483	Protein conserved in bacteria
HCU65_12910	COG0705	Rhomboid family
HCU65_12910	COG0457	Tetratricopeptide repeat
HCU65_12920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HCU65_12930	COG0438	transferase activity, transferring glycosyl groups
HCU65_12945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HCU65_12950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCU65_12955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCU65_12960	COG0581	inorganic phosphate transmembrane transporter activity
HCU65_12965	COG0573	inorganic phosphate transmembrane transporter activity
HCU65_12970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCU65_12975	COG0768	penicillin binding
HCU65_12980	COG0477	Major facilitator Superfamily
HCU65_12985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCU65_12990	COG2839	Protein conserved in bacteria
HCU65_12995	COG5521	maltodextrose utilization protein MalA
HCU65_13000	COG1388	LysM domain
HCU65_13010	COG4709	membrane
HCU65_13015	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HCU65_13020	COG0735	belongs to the Fur family
HCU65_13025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCU65_13035	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HCU65_13040	COG0513	Belongs to the DEAD box helicase family
HCU65_13050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HCU65_13055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCU65_13060	COG2384	SAM-dependent methyltransferase
HCU65_13065	COG2010	Cytochrome c
HCU65_13070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCU65_13075	COG0358	DNA primase activity
HCU65_13080	COG1671	Belongs to the UPF0178 family
HCU65_13085	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HCU65_13090	COG0517	IMP dehydrogenase activity
HCU65_13095	COG0751	glycine-tRNA ligase activity
HCU65_13100	COG0752	glycyl-tRNA synthetase alpha subunit
HCU65_13105	COG1381	Involved in DNA repair and RecF pathway recombination
HCU65_13115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HCU65_13120	COG0295	cytidine deaminase activity
HCU65_13125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HCU65_13135	COG1480	7TM receptor with intracellular HD hydrolase
HCU65_13140	COG1702	phosphate starvation-inducible protein PhoH
HCU65_13145	COG0561	phosphatase activity
HCU65_13160	COG4864	UPF0365 protein
HCU65_13165	COG1030	water channel activity
HCU65_13170	COG1610	YqeY-like protein
HCU65_13180	COG1283	sodium-dependent phosphate transmembrane transporter activity
HCU65_13185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCU65_13190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HCU65_13210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HCU65_13215	COG1420	regulation of RNA biosynthetic process
HCU65_13220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCU65_13225	COG0481	GTPase activity
HCU65_13235	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCU65_13250	COG1466	dna polymerase III delta subunit
HCU65_13265	COG0658	competence protein
HCU65_13265	COG2333	competence protein COMEC
HCU65_13270	COG2131	deaminase
HCU65_13275	COG1555	photosystem II stabilization
HCU65_13275	COG1596	polysaccharide export
HCU65_13280	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCU65_13285	COG2226	methyltransferase
HCU65_13290	COG0799	negative regulation of ribosome biogenesis
HCU65_13295	COG1713	HD superfamily hydrolase involved in NAD metabolism
HCU65_13300	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HCU65_13305	COG1534	Rna-binding protein
HCU65_13310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCU65_13315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HCU65_13320	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HCU65_13330	COG2755	lipolytic protein G-D-S-L family
HCU65_13345	COG0398	Pfam SNARE associated Golgi protein
HCU65_13380	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCU65_13385	COG0114	fumarate hydratase activity
HCU65_13390	COG0583	DNA-binding transcription factor activity
HCU65_13405	COG1733	regulation of RNA biosynthetic process
HCU65_13430	COG2124	cytochrome p450
HCU65_13440	COG1309	transcriptional regulator
HCU65_13445	COG2732	(Barnase) inhibitor
HCU65_13485	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HCU65_13490	COG0583	DNA-binding transcription factor activity
HCU65_13500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCU65_13515	COG3443	Belongs to the bacterial solute-binding protein 9 family
HCU65_13530	COG0583	DNA-binding transcription factor activity
HCU65_13535	COG2814	Major facilitator Superfamily
HCU65_13540	COG2176	DNA-directed DNA polymerase activity
HCU65_13545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCU65_13545	COG2124	cytochrome p450
HCU65_13550	COG1309	transcriptional regulator
HCU65_13555	COG2226	methyltransferase
HCU65_13570	COG2116	formate transmembrane transporter activity
HCU65_13575	COG5609	conserved protein (DUF2294)
HCU65_13580	COG3383	formate dehydrogenase (NAD+) activity
HCU65_13585	COG2427	Protein of unknown function (DUF1641)
HCU65_13595	COG0626	cystathionine gamma-synthase activity
HCU65_13600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCU65_13605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HCU65_13610	COG2226	methyltransferase
HCU65_13625	COG0768	penicillin binding
HCU65_13630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCU65_13635	COG0572	uridine kinase
HCU65_13640	COG0826	peptidase U32
HCU65_13645	COG0826	peptidase U32
HCU65_13650	COG4122	O-methyltransferase activity
HCU65_13655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HCU65_13660	COG3906	Belongs to the UPF0473 family
HCU65_13665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HCU65_13670	COG4472	Bacterial protein of unknown function (DUF965)
HCU65_13675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCU65_13680	COG0628	permease
HCU65_13685	COG1126	abc transporter atp-binding protein
HCU65_13690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCU65_13695	COG0765	amino acid transport
HCU65_13700	COG0765	amino acid transport
HCU65_13715	COG3881	PFAM PRC-barrel domain
HCU65_13720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HCU65_13725	COG0457	Tetratricopeptide repeat
HCU65_13735	COG1104	cysteine desulfurase activity
HCU65_13740	COG1959	2 iron, 2 sulfur cluster binding
HCU65_13745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HCU65_13760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HCU65_13770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HCU65_13785	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCU65_13785	COG4991	sh3 domain protein
HCU65_13785	COG3103	Sh3 type 3 domain protein
HCU65_13790	COG1490	D-aminoacyl-tRNA deacylase activity
HCU65_13795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCU65_13805	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HCU65_13805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCU65_13810	COG5416	Lipopolysaccharide assembly protein A domain
HCU65_13815	COG0490	domain, Protein
HCU65_13820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCU65_13820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCU65_13830	COG2244	polysaccharide biosynthetic process
HCU65_13835	COG2323	membrane
HCU65_13845	COG1862	Preprotein translocase
HCU65_13855	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HCU65_13865	COG2255	four-way junction helicase activity
HCU65_13880	COG2814	Major facilitator Superfamily
HCU65_13885	COG2112	serine threonine protein kinase
HCU65_13895	COG0217	transcriptional regulatory protein
HCU65_13915	COG3394	polysaccharide catabolic process
HCU65_13920	COG2188	Transcriptional regulator
HCU65_13925	COG1486	melibiose metabolic process
HCU65_13930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCU65_13935	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCU65_13940	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCU65_13955	COG1388	LysM domain
HCU65_13960	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HCU65_13965	COG0157	Belongs to the NadC ModD family
HCU65_13970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCU65_13975	COG1104	cysteine desulfurase activity
HCU65_13980	COG1827	regulation of RNA biosynthetic process
HCU65_13985	COG0077	Prephenate dehydratase
HCU65_13990	COG4492	Belongs to the UPF0735 family
HCU65_13995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HCU65_14000	COG3290	protein histidine kinase activity
HCU65_14005	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HCU65_14010	COG2868	ribosomal protein
HCU65_14015	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HCU65_14020	COG1994	Peptidase M50
HCU65_14025	COG0739	heme binding
HCU65_14030	COG2894	cell division
HCU65_14035	COG0850	regulation of cytokinetic process
HCU65_14040	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HCU65_14050	COG1077	Cell shape determining protein MreB Mrl
HCU65_14055	COG2003	Belongs to the UPF0758 family
HCU65_14060	COG0424	maF-like protein
HCU65_14070	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HCU65_14075	COG0285	dihydrofolate synthase activity
HCU65_14080	COG0525	valine-tRNA ligase activity
HCU65_14090	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCU65_14095	COG1388	LysM domain
HCU65_14100	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCU65_14105	COG0113	porphobilinogen synthase activity
HCU65_14110	COG1587	Uroporphyrinogen-III synthase
HCU65_14120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCU65_14125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HCU65_14135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HCU65_14140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HCU65_14145	COG1067	ATP-dependent peptidase activity
HCU65_14145	COG0470	DNA polymerase III
HCU65_14155	COG0544	peptidyl-prolyl cis-trans isomerase activity
HCU65_14160	COG1477	protein flavinylation
HCU65_14160	COG0457	Tetratricopeptide repeat
HCU65_14165	COG0066	3-isopropylmalate dehydratase activity
HCU65_14170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HCU65_14175	COG0473	3-isopropylmalate dehydrogenase activity
HCU65_14180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCU65_14185	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HCU65_14190	COG0440	acetolactate synthase activity
HCU65_14195	COG0028	Belongs to the TPP enzyme family
HCU65_14200	COG0454	-acetyltransferase
HCU65_14205	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HCU65_14215	COG0622	Phosphoesterase
HCU65_14220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HCU65_14225	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HCU65_14230	COG5401	PFAM Sporulation and spore germination
HCU65_14235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HCU65_14240	COG1846	Transcriptional regulator
HCU65_14245	COG2197	response regulator
HCU65_14250	COG0824	Thioesterase
HCU65_14255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCU65_14260	COG1053	succinate dehydrogenase
HCU65_14265	COG2009	succinate dehydrogenase
HCU65_14270	COG1719	4-vinyl reductase, 4VR
HCU65_14275	COG0527	aspartate kinase activity
HCU65_14280	COG0322	excinuclease ABC activity
HCU65_14285	COG3118	belongs to the thioredoxin family
HCU65_14290	COG3534	alpha-L-arabinofuranosidase
HCU65_14295	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HCU65_14300	COG2086	electron transfer activity
HCU65_14305	COG1024	Enoyl-CoA hydratase
HCU65_14310	COG1309	transcriptional regulator
HCU65_14315	COG0318	PFAM AMP-dependent synthetase and ligase
HCU65_14320	COG3766	membrane
HCU65_14325	COG1193	negative regulation of DNA recombination
HCU65_14330	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HCU65_14330	COG1796	DNA polymerase
HCU65_14335	COG1286	toxin biosynthetic process
HCU65_14340	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HCU65_14350	COG0072	phenylalanine-tRNA ligase activity
HCU65_14350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCU65_14355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HCU65_14360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCU65_14370	COG3835	regulator
HCU65_14375	COG0277	FAD linked oxidase domain protein
HCU65_14380	COG0247	lactate metabolic process
HCU65_14385	COG0346	lactoylglutathione lyase activity
HCU65_14390	COG1966	Carbon starvation protein
HCU65_14395	COG3534	alpha-L-arabinofuranosidase
HCU65_14400	COG0395	ABC-type sugar transport system, permease component
HCU65_14405	COG1175	transmembrane transport
HCU65_14410	COG1653	transport
HCU65_14415	COG0371	Dehydrogenase
HCU65_14420	COG0647	UMP catabolic process
HCU65_14425	COG0235	Class ii aldolase
HCU65_14430	COG1069	ribulokinase activity
HCU65_14435	COG2160	L-arabinose isomerase activity
HCU65_14460	COG3507	Belongs to the glycosyl hydrolase 43 family
HCU65_14465	COG1363	Peptidase, m42
HCU65_14475	COG3326	Membrane
HCU65_14480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HCU65_14485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HCU65_14490	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HCU65_14500	COG1346	cytolysis
HCU65_14510	COG3279	Response regulator of the LytR AlgR family
HCU65_14515	COG3275	phosphorelay sensor kinase activity
HCU65_14520	COG1011	Hydrolase
HCU65_14525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HCU65_14535	COG0398	Pfam SNARE associated Golgi protein
HCU65_14540	COG1484	DNA-dependent DNA replication
HCU65_14545	COG3611	Membrane attachment protein
HCU65_14550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HCU65_14555	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HCU65_14560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCU65_14565	COG1733	regulation of RNA biosynthetic process
HCU65_14570	COG2814	Major facilitator Superfamily
HCU65_14575	COG0656	L-ascorbic acid biosynthetic process
HCU65_14580	COG0237	dephospho-CoA kinase activity
HCU65_14585	COG1971	Probably functions as a manganese efflux pump
HCU65_14590	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HCU65_14595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCU65_14595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCU65_14600	COG5002	protein histidine kinase activity
HCU65_14605	COG0745	RESPONSE REGULATOR receiver
HCU65_14615	COG0538	isocitrate dehydrogenase activity
HCU65_14620	COG0372	Belongs to the citrate synthase family
HCU65_14625	COG2707	UPF0756 membrane protein
HCU65_14630	COG0628	permease
HCU65_14635	COG3030	protein affecting phage T7 exclusion by the F plasmid
HCU65_14640	COG0469	pyruvate kinase activity
HCU65_14650	COG0825	malonyl-CoA metabolic process
HCU65_14655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HCU65_14660	COG0281	malic enzyme
HCU65_14665	COG0587	DNA-directed DNA polymerase activity
HCU65_14685	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HCU65_14695	COG4109	DRTGG domain
HCU65_14700	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HCU65_14705	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_14710	COG0165	Argininosuccinate lyase
HCU65_14715	COG0137	argininosuccinate synthase activity
HCU65_14720	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCU65_14730	COG0827	DNA restriction-modification system
HCU65_14735	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HCU65_14740	COG3874	Sporulation protein YtfJ
HCU65_14750	COG1714	RDD family
HCU65_14755	COG0616	signal peptide processing
HCU65_14760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCU65_14765	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HCU65_14770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCU65_14780	COG0301	tRNA thio-modification
HCU65_14785	COG1104	cysteine desulfurase activity
HCU65_14790	COG1114	Component of the transport system for branched-chain amino acids
HCU65_14795	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HCU65_14800	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HCU65_14805	COG1309	transcriptional regulator
HCU65_14810	COG1956	GAF domain-containing protein
HCU65_14815	COG2203	Gaf domain
HCU65_14815	COG2199	diguanylate cyclase activity
HCU65_14825	COG2267	carboxylic ester hydrolase activity
HCU65_14845	COG1335	isochorismatase
HCU65_14865	COG2259	Doxx family
HCU65_14870	COG0346	lactoylglutathione lyase activity
HCU65_14880	COG0400	carboxylic ester hydrolase activity
HCU65_14885	COG0697	spore germination
HCU65_14890	COG0583	DNA-binding transcription factor activity
HCU65_14895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCU65_14900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCU65_14905	COG0454	-acetyltransferase
HCU65_14910	COG0517	IMP dehydrogenase activity
HCU65_14915	COG0123	including yeast histone deacetylase and acetoin utilization protein
HCU65_14920	COG1360	Flagellar Motor Protein
HCU65_14925	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HCU65_14930	COG1609	Transcriptional regulator
HCU65_14935	COG1605	Chorismate mutase
HCU65_14935	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HCU65_14940	COG3118	belongs to the thioredoxin family
HCU65_14945	COG4980	gas vesicle protein
HCU65_14950	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HCU65_14960	COG1674	ftsk spoiiie
HCU65_14965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCU65_14970	COG4848	Belongs to the UPF0354 family
HCU65_14975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCU65_14985	COG1363	Peptidase, m42
HCU65_14990	COG5584	Small secreted protein
HCU65_14995	COG0281	malic enzyme
HCU65_15000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCU65_15005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HCU65_15015	COG0510	thiamine kinase activity
HCU65_15020	COG1523	belongs to the glycosyl hydrolase 13 family
HCU65_15025	COG1597	lipid kinase activity
HCU65_15035	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HCU65_15040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCU65_15045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCU65_15050	COG2252	PERMEase
HCU65_15055	COG1349	DNA-binding transcription factor activity
HCU65_15060	COG1187	pseudouridine synthase activity
HCU65_15065	COG2244	polysaccharide biosynthetic process
HCU65_15070	COG2081	HI0933 family
HCU65_15075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HCU65_15085	COG5578	integral membrane protein
HCU65_15090	COG0673	inositol 2-dehydrogenase activity
HCU65_15095	COG1653	transport
HCU65_15100	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HCU65_15105	COG4209	transmembrane transport
HCU65_15110	COG2207	Transcriptional regulator
HCU65_15115	COG1653	transport
HCU65_15120	COG0395	ABC-type sugar transport system, permease component
HCU65_15125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCU65_15130	COG2124	cytochrome p450
HCU65_15135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HCU65_15145	COG0156	8-amino-7-oxononanoate synthase activity
HCU65_15150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCU65_15155	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HCU65_15160	COG1073	alpha beta
HCU65_15165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCU65_15170	COG0495	leucyl-tRNA aminoacylation
HCU65_15180	COG1366	Belongs to the anti-sigma-factor antagonist family
HCU65_15180	COG2202	Pas domain
HCU65_15185	COG2814	Major facilitator Superfamily
HCU65_15190	COG2433	Pfam Transposase IS66
HCU65_15195	COG0577	efflux transmembrane transporter activity
HCU65_15200	COG1136	(ABC) transporter
HCU65_15205	COG2205	protein histidine kinase activity
HCU65_15210	COG0745	RESPONSE REGULATOR receiver
HCU65_15215	COG0577	efflux transmembrane transporter activity
HCU65_15220	COG1136	(ABC) transporter
HCU65_15230	COG1131	(ABC) transporter
HCU65_15235	COG1725	Transcriptional regulator
HCU65_15250	COG1242	4 iron, 4 sulfur cluster binding
HCU65_15255	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HCU65_15265	COG2267	carboxylic ester hydrolase activity
HCU65_15270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCU65_15275	COG1113	amino acid transport
HCU65_15280	COG0367	asparagine synthase
HCU65_15290	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HCU65_15300	COG1506	peptidase
HCU65_15305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCU65_15310	COG1116	anion transmembrane transporter activity
HCU65_15315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCU65_15320	COG0494	nUDIX hydrolase
HCU65_15330	COG4824	toxin secretion phage lysis holin
HCU65_15335	COG0783	Belongs to the Dps family
HCU65_15355	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HCU65_15360	COG0288	reversible hydration of carbon dioxide
HCU65_15365	COG0523	cobalamin synthesis protein
HCU65_15375	COG1271	oxidase subunit
HCU65_15380	COG1294	oxidase, subunit
HCU65_15390	COG4305	rare lipoprotein A
HCU65_15395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCU65_15400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCU65_15400	COG1321	iron dependent repressor
HCU65_15405	COG1121	(ABC) transporter
HCU65_15410	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCU65_15415	COG4948	Mandelate Racemase Muconate Lactonizing
HCU65_15420	COG0318	PFAM AMP-dependent synthetase and ligase
HCU65_15425	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HCU65_15430	COG0596	Alpha beta hydrolase
HCU65_15435	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HCU65_15440	COG1169	isochorismate synthase
HCU65_15445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCU65_15450	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCU65_15455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCU65_15460	COG0438	transferase activity, transferring glycosyl groups
HCU65_15470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCU65_15475	COG0438	transferase activity, transferring glycosyl groups
HCU65_15480	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCU65_15485	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HCU65_15490	COG0058	SHG alpha-glucan phosphorylase activity
HCU65_15495	COG0297	glycogen (starch) synthase activity
HCU65_15500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HCU65_15505	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HCU65_15510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HCU65_15635	COG3859	Proton-coupled thiamine transporter YuaJ
HCU65_15640	COG3764	Sortase (surface protein transpeptidase)
HCU65_15650	COG2268	Band 7 protein
HCU65_15655	COG1585	Membrane protein implicated in regulation of membrane protease activity
HCU65_15660	COG2318	DinB family
HCU65_15670	COG1454	alcohol dehydrogenase
HCU65_15675	COG1012	belongs to the aldehyde dehydrogenase family
HCU65_15680	COG1510	regulation of RNA biosynthetic process
HCU65_15690	COG0569	domain protein
HCU65_15695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCU65_15700	COG4682	membrane
HCU65_15705	COG1705	Flagellar rod assembly protein muramidase FlgJ
HCU65_15710	COG0477	Major facilitator Superfamily
HCU65_15725	COG0628	permease
HCU65_15730	COG0673	inositol 2-dehydrogenase activity
HCU65_15735	COG0693	protein deglycase activity
HCU65_15740	COG4806	L-rhamnose isomerase
HCU65_15745	COG3254	rhamnose metabolic process
HCU65_15750	COG1070	Carbohydrate kinase
HCU65_15755	COG1349	DNA-binding transcription factor activity
HCU65_15760	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_15760	COG3347	Dehydrogenase
HCU65_15765	COG0840	transmembrane signaling receptor activity
HCU65_15770	COG0840	transmembrane signaling receptor activity
HCU65_15775	COG0840	transmembrane signaling receptor activity
HCU65_15780	COG0840	transmembrane signaling receptor activity
HCU65_15795	COG2070	2-Nitropropane dioxygenase
HCU65_15800	COG0432	Pfam Uncharacterised protein family UPF0047
HCU65_15805	COG0366	Alpha amylase catalytic
HCU65_15810	COG1253	flavin adenine dinucleotide binding
HCU65_15815	COG2738	Putative neutral zinc metallopeptidase
HCU65_15830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCU65_15845	COG0166	Belongs to the GPI family
HCU65_15850	COG1979	alcohol dehydrogenase
HCU65_15855	COG1979	alcohol dehydrogenase
HCU65_15860	COG2155	Conserved Protein
HCU65_15865	COG1098	S1 RNA binding domain
HCU65_15870	COG0436	Aminotransferase
HCU65_15875	COG1522	sequence-specific DNA binding
HCU65_15880	COG2267	carboxylic ester hydrolase activity
HCU65_15890	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HCU65_15895	COG2205	protein histidine kinase activity
HCU65_15905	COG5018	Exonuclease
HCU65_15915	COG2814	Major facilitator Superfamily
HCU65_15920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCU65_15925	COG3011	Protein conserved in bacteria
HCU65_15935	COG3290	protein histidine kinase activity
HCU65_15940	COG4565	transcriptional regulatory protein
HCU65_15945	COG1744	ABC transporter substrate-binding protein PnrA-like
HCU65_15950	COG3845	ABC transporter
HCU65_15955	COG4603	Belongs to the binding-protein-dependent transport system permease family
HCU65_15960	COG1079	Belongs to the binding-protein-dependent transport system permease family
HCU65_15965	COG3493	citrate carrier protein
HCU65_15975	COG2111	Na H antiporter
HCU65_15975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCU65_15980	COG2111	Na H antiporter
HCU65_15985	COG1006	Multisubunit Na H antiporter MnhC subunit
HCU65_15990	COG0651	ATP synthesis coupled electron transport
HCU65_15995	COG1863	multisubunit Na H antiporter MnhE subunit
HCU65_16000	COG2212	antiporter activity
HCU65_16005	COG1320	monovalent cation:proton antiporter activity
HCU65_16010	COG2050	protein possibly involved in aromatic compounds catabolism
HCU65_16015	COG2197	response regulator
HCU65_16020	COG4585	Histidine kinase
HCU65_16030	COG0142	geranyltranstransferase activity
HCU65_16045	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HCU65_16050	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HCU65_16055	COG1335	isochorismatase
HCU65_16060	COG5506	Protein of unknown function (DUF1694)
HCU65_16075	COG0628	permease
HCU65_16085	COG1418	mRNA catabolic process
HCU65_16090	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_16100	COG1511	domain protein
HCU65_16105	COG1674	ftsk spoiiie
HCU65_16105	COG0433	COG0433 Predicted ATPase
HCU65_16110	COG4499	WXG100 protein secretion system (Wss), protein YukC
HCU65_16115	COG5417	Belongs to the EsaB family
HCU65_16120	COG4842	Belongs to the WXG100 family
HCU65_16125	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HCU65_16125	COG2508	Transcriptional regulator
HCU65_16130	COG0686	Belongs to the AlaDH PNT family
HCU65_16135	COG5634	Uncharacterized conserved protein (DUF2278)
HCU65_16140	COG3251	PFAM MbtH domain protein
HCU65_16145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCU65_16150	COG3433	isochorismatase activity
HCU65_16150	COG1535	isochorismatase
HCU65_16155	COG1021	2,3-dihydroxybenzoate-AMP ligase
HCU65_16160	COG1169	isochorismate synthase
HCU65_16165	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_16170	COG2819	hydrolase of the alpha beta superfamily
HCU65_16185	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HCU65_16190	COG1268	BioY protein
HCU65_16195	COG2056	Na+-H+ antiporter family
HCU65_16200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HCU65_16205	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HCU65_16210	COG3584	3D domain protein
HCU65_16225	COG1252	NADH dehydrogenase
HCU65_16240	COG0516	GMP reductase activity
HCU65_16245	COG0316	Belongs to the HesB IscA family
HCU65_16250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HCU65_16255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCU65_16260	COG4844	belongs to the
HCU65_16265	COG1252	NADH dehydrogenase
HCU65_16270	COG3479	Phenolic acid decarboxylase
HCU65_16275	COG4837	Protein of unknown function (DUF1462)
HCU65_16280	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HCU65_16285	COG1506	peptidase
HCU65_16285	COG4946	Tricorn protease homolog
HCU65_16285	COG0823	Involved in the tonB-independent uptake of proteins
HCU65_16290	COG0083	homoserine kinase activity
HCU65_16295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HCU65_16300	COG0460	homoserine dehydrogenase
HCU65_16305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCU65_16310	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HCU65_16315	COG0647	UMP catabolic process
HCU65_16320	COG2445	Protein of unknown function DUF86
HCU65_16325	COG4470	Protein conserved in bacteria
HCU65_16340	COG0739	heme binding
HCU65_16350	COG3377	Domain of unknown function (DUF1805)
HCU65_16355	COG0737	Belongs to the 5'-nucleotidase family
HCU65_16360	COG0730	response to heat
HCU65_16365	COG1801	Protein of unknown function DUF72
HCU65_16380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCU65_16385	COG2508	Transcriptional regulator
HCU65_16390	COG2233	PERMEase
HCU65_16395	COG1595	DNA-templated transcription, initiation
HCU65_16475	COG1131	(ABC) transporter
HCU65_16500	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HCU65_16505	COG2814	Major facilitator Superfamily
HCU65_16510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HCU65_16515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCU65_16520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCU65_16525	COG2356	endonuclease I
HCU65_16535	COG3842	ATPase activity
HCU65_16540	COG2188	Transcriptional regulator
HCU65_16545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCU65_16550	COG0395	ABC-type sugar transport system, permease component
HCU65_16555	COG1175	transmembrane transport
HCU65_16560	COG1653	transport
HCU65_16565	COG2222	sugar isomerase
HCU65_16570	COG0322	excinuclease ABC activity
HCU65_16575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCU65_16580	COG0719	Fe-S assembly protein
HCU65_16585	COG0822	iron-sulfur transferase activity
HCU65_16590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCU65_16595	COG0719	Fe-S assembly protein
HCU65_16600	COG0396	ATPase activity
HCU65_16610	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCU65_16615	COG1464	Belongs to the NlpA lipoprotein family
HCU65_16620	COG2011	ABC-type metal ion transport system permease component
HCU65_16625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCU65_16635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCU65_16640	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HCU65_16650	COG0509	glycine decarboxylation via glycine cleavage system
HCU65_16655	COG1393	Belongs to the ArsC family
HCU65_16660	COG1960	acyl-CoA dehydrogenase activity
HCU65_16665	COG0183	Belongs to the thiolase family
HCU65_16670	COG1024	Enoyl-CoA hydratase
HCU65_16670	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCU65_16690	COG5577	PFAM Coat F domain
HCU65_16695	COG1846	Transcriptional regulator
HCU65_16700	COG0477	Major facilitator Superfamily
HCU65_16710	COG1120	ATPase activity
HCU65_16725	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_16730	COG0783	Belongs to the Dps family
HCU65_16735	COG0488	(ABC) transporter
HCU65_16755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCU65_16760	COG0745	RESPONSE REGULATOR receiver
HCU65_16765	COG2205	protein histidine kinase activity
HCU65_16765	COG2770	Histidine kinase
HCU65_16775	COG1309	transcriptional regulator
HCU65_16780	COG0114	fumarate hydratase activity
HCU65_16790	COG0697	spore germination
HCU65_16795	COG0814	amino acid
HCU65_16805	COG2197	response regulator
HCU65_16810	COG4585	Histidine kinase
HCU65_16815	COG4758	membrane
HCU65_16820	COG3595	metallopeptidase activity
HCU65_16825	COG1842	Phage shock protein A
HCU65_16830	COG4758	membrane
HCU65_16835	COG2814	Major facilitator Superfamily
HCU65_16840	COG2096	Adenosyltransferase
HCU65_16845	COG1120	ATPase activity
HCU65_16850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU65_16855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCU65_16860	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_16865	COG3386	PFAM SMP-30 Gluconolaconase
HCU65_16870	COG2205	protein histidine kinase activity
HCU65_16875	COG0745	RESPONSE REGULATOR receiver
HCU65_16885	COG1191	sigma factor activity
HCU65_16895	COG2140	Oxalate decarboxylase
HCU65_16905	COG0577	efflux transmembrane transporter activity
HCU65_16910	COG1136	(ABC) transporter
HCU65_16915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCU65_16920	COG1120	ATPase activity
HCU65_16925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU65_16930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU65_16935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCU65_16945	COG0531	amino acid
HCU65_16960	COG1988	membrane-bound metal-dependent
HCU65_16965	COG1368	sulfuric ester hydrolase activity
HCU65_16970	COG1910	domain protein
HCU65_16975	COG0725	ABC transporter, periplasmic molybdate-binding protein
HCU65_16980	COG4149	molybdate abc transporter
HCU65_16990	COG0656	L-ascorbic acid biosynthetic process
HCU65_17010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCU65_17015	COG3973	AAA domain
HCU65_17020	COG2860	membrane
HCU65_17030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HCU65_17035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HCU65_17040	COG2217	Heavy metal translocating P-type atpase
HCU65_17045	COG2217	Heavy metal translocating P-type atpase
HCU65_17050	COG2608	mercury ion transmembrane transporter activity
HCU65_17055	COG1937	Protein conserved in bacteria
HCU65_17060	COG0673	inositol 2-dehydrogenase activity
HCU65_17065	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HCU65_17070	COG1289	transmembrane transporter activity
HCU65_17085	COG2076	Multidrug Resistance protein
HCU65_17090	COG1309	transcriptional regulator
HCU65_17100	COG1216	Glycosyl transferase, family 2
HCU65_17100	COG1442	glycosyl transferase family 8
HCU65_17110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HCU65_17115	COG0557	exoribonuclease II activity
HCU65_17120	COG1647	Serine aminopeptidase, S33
HCU65_17125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCU65_17130	COG1476	TRANSCRIPTIONal
HCU65_17135	COG1396	sequence-specific DNA binding
HCU65_17140	COG1396	sequence-specific DNA binding
HCU65_17145	COG1733	regulation of RNA biosynthetic process
HCU65_17150	COG0840	transmembrane signaling receptor activity
HCU65_17155	COG1174	glycine betaine transport
HCU65_17160	COG1732	Glycine betaine
HCU65_17165	COG1174	glycine betaine transport
HCU65_17170	COG0517	IMP dehydrogenase activity
HCU65_17170	COG1125	glycine betaine transport
HCU65_17175	COG1510	regulation of RNA biosynthetic process
HCU65_17180	COG1174	glycine betaine transport
HCU65_17185	COG1732	Glycine betaine
HCU65_17190	COG1174	glycine betaine transport
HCU65_17195	COG1125	glycine betaine transport
HCU65_17195	COG0517	IMP dehydrogenase activity
HCU65_17200	COG1510	regulation of RNA biosynthetic process
HCU65_17205	COG2095	MarC family integral membrane protein
HCU65_17210	COG3064	Membrane
HCU65_17215	COG4640	response to antibiotic
HCU65_17220	COG0456	acetyltransferase
HCU65_17235	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCU65_17255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCU65_17260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCU65_17270	COG2234	aminopeptidase activity
HCU65_17280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HCU65_17290	COG0126	phosphoglycerate kinase activity
HCU65_17295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCU65_17300	COG2390	Transcriptional regulator
HCU65_17305	COG2814	Major facilitator Superfamily
HCU65_17310	COG1609	Transcriptional regulator
HCU65_17315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCU65_17320	COG0583	DNA-binding transcription factor activity
HCU65_17325	COG0697	spore germination
HCU65_17330	COG1113	amino acid transport
HCU65_17335	COG3858	chitin binding
HCU65_17340	COG1556	Lactate utilization protein
HCU65_17345	COG1139	Iron-sulfur cluster binding protein
HCU65_17350	COG0247	lactate metabolic process
HCU65_17360	COG2186	Transcriptional regulator
HCU65_17365	COG1620	l-lactate permease
HCU65_17370	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HCU65_17380	COG5039	Polysaccharide pyruvyl transferase
HCU65_17385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCU65_17390	COG0110	maltose O-acetyltransferase activity
HCU65_17395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCU65_17400	COG2244	polysaccharide biosynthetic process
HCU65_17405	COG1216	Glycosyl transferase, family 2
HCU65_17410	COG5039	Polysaccharide pyruvyl transferase
HCU65_17415	COG1216	Glycosyl transferase, family 2
HCU65_17425	COG0438	transferase activity, transferring glycosyl groups
HCU65_17430	COG1215	transferase activity, transferring glycosyl groups
HCU65_17435	COG0438	transferase activity, transferring glycosyl groups
HCU65_17440	COG1086	Polysaccharide biosynthesis protein
HCU65_17445	COG0489	protein tyrosine kinase activity
HCU65_17450	COG3944	biosynthesis protein
HCU65_17455	COG1396	sequence-specific DNA binding
HCU65_17480	COG1131	(ABC) transporter
HCU65_17500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCU65_17505	COG0583	DNA-binding transcription factor activity
HCU65_17520	COG1621	beta-fructofuranosidase activity
HCU65_17525	COG1621	beta-fructofuranosidase activity
HCU65_17530	COG0531	amino acid
HCU65_17535	COG1309	transcriptional regulator
HCU65_17540	COG2076	Multidrug Resistance protein
HCU65_17545	COG2076	Multidrug Resistance protein
HCU65_17550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCU65_17575	COG1611	Belongs to the LOG family
HCU65_17580	COG1694	Mazg nucleotide pyrophosphohydrolase
HCU65_17585	COG0659	secondary active sulfate transmembrane transporter activity
HCU65_17590	COG0288	reversible hydration of carbon dioxide
HCU65_17595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCU65_17600	COG0577	efflux transmembrane transporter activity
HCU65_17605	COG1136	(ABC) transporter
HCU65_17610	COG5002	protein histidine kinase activity
HCU65_17615	COG0745	RESPONSE REGULATOR receiver
HCU65_17620	COG4290	ribonuclease
HCU65_17625	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HCU65_17630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU65_17640	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HCU65_17645	COG1660	Displays ATPase and GTPase activities
HCU65_17650	COG1051	belongs to the nudix hydrolase family
HCU65_17655	COG0492	ferredoxin-NADP+ reductase activity
HCU65_17660	COG0791	NLP P60 protein
HCU65_17660	COG3883	PFAM NLP P60 protein
HCU65_17665	COG0457	Tetratricopeptide repeat
HCU65_17670	COG1132	(ABC) transporter
HCU65_17680	COG1247	-acetyltransferase
HCU65_17685	COG0140	phosphoribosyl-ATP diphosphatase activity
HCU65_17685	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HCU65_17690	COG0107	imidazoleglycerol-phosphate synthase activity
HCU65_17695	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HCU65_17705	COG0131	Imidazoleglycerol-phosphate dehydratase
HCU65_17710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCU65_17715	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HCU65_17720	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HCU65_17725	COG4990	cell redox homeostasis
HCU65_17730	COG5297	Belongs to the glycosyl hydrolase family 6
HCU65_17735	COG0110	maltose O-acetyltransferase activity
HCU65_17740	COG0546	phosphoglycolate phosphatase activity
HCU65_17745	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HCU65_17750	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HCU65_17755	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HCU65_17760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HCU65_17770	COG2188	Transcriptional regulator
HCU65_17775	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HCU65_17780	COG1950	PFAM Membrane protein of
HCU65_17785	COG1983	PspC domain protein
HCU65_17790	COG3595	metallopeptidase activity
HCU65_17805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCU65_17815	COG4897	Protein conserved in bacteria
HCU65_17820	COG0574	Belongs to the PEP-utilizing enzyme family
HCU65_17820	COG3848	Pyruvate phosphate dikinase
HCU65_17825	COG1309	transcriptional regulator
HCU65_17830	COG2814	Major facilitator Superfamily
HCU65_17845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCU65_17855	COG0793	Belongs to the peptidase S41A family
HCU65_17855	COG3409	Peptidoglycan-binding domain 1 protein
HCU65_17860	COG2177	Part of the ABC transporter FtsEX involved in
HCU65_17865	COG2884	Cell division ATP-binding protein ftsE
HCU65_17870	COG2010	Cytochrome c
HCU65_17875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCU65_17885	COG0653	protein targeting
HCU65_17890	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCU65_17905	COG1516	flagellar protein fliS
HCU65_17910	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HCU65_17915	COG1334	flagellar protein FlaG
HCU65_17920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HCU65_17925	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HCU65_17930	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HCU65_17940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HCU65_17945	COG1256	bacterial-type flagellum assembly
HCU65_17945	COG4786	Flagellar basal body rod
HCU65_17950	COG3418	PFAM FlgN family protein
HCU65_17955	COG2747	anti-sigma28 factor FlgM
HCU65_17965	COG1040	competence protein
HCU65_17975	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HCU65_17980	COG1307	EDD domain protein, DegV family
HCU65_17985	COG2197	response regulator
HCU65_17990	COG4585	Histidine kinase
HCU65_17995	COG1739	Uncharacterized protein family UPF0029
HCU65_18000	COG1316	TRANSCRIPTIONal
HCU65_18005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCU65_18010	COG0438	transferase activity, transferring glycosyl groups
HCU65_18015	COG1215	transferase activity, transferring glycosyl groups
HCU65_18020	COG3206	protein involved in exopolysaccharide biosynthesis
HCU65_18025	COG3307	-O-antigen
HCU65_18030	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCU65_18035	COG0297	glycogen (starch) synthase activity
HCU65_18035	COG0438	transferase activity, transferring glycosyl groups
HCU65_18040	COG2244	polysaccharide biosynthetic process
HCU65_18055	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCU65_18055	COG2247	cell wall binding repeat
HCU65_18060	COG2247	cell wall binding repeat
HCU65_18060	COG2385	sporulation resulting in formation of a cellular spore
HCU65_18070	COG1316	TRANSCRIPTIONal
HCU65_18075	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCU65_18080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCU65_18085	COG1134	teichoic acid transport
HCU65_18090	COG1682	transport, permease protein
HCU65_18095	COG0463	Glycosyl transferase, family 2
HCU65_18095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCU65_18100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCU65_18105	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HCU65_18110	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HCU65_18115	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCU65_18120	COG4193	domain, Protein
HCU65_18125	COG1482	cell wall glycoprotein biosynthetic process
HCU65_18130	COG0697	spore germination
HCU65_18135	COG0814	amino acid
HCU65_18150	COG2814	Major facilitator Superfamily
HCU65_18155	COG1316	TRANSCRIPTIONal
HCU65_18160	COG0561	phosphatase activity
HCU65_18165	COG0791	NLP P60 protein
HCU65_18185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HCU65_18190	COG0697	spore germination
HCU65_18195	COG0531	amino acid
HCU65_18210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCU65_18215	COG1869	D-ribose catabolic process
HCU65_18220	COG1129	ABC transporter
HCU65_18225	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCU65_18230	COG1879	ABC-type sugar transport system periplasmic component
HCU65_18235	COG3103	Sh3 type 3 domain protein
HCU65_18245	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCU65_18250	COG3527	Alpha-acetolactate decarboxylase
HCU65_18255	COG0028	Belongs to the TPP enzyme family
HCU65_18260	COG0583	DNA-binding transcription factor activity
HCU65_18265	COG5337	Spore coat protein CotH
HCU65_18275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCU65_18280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU65_18295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCU65_18310	COG1522	sequence-specific DNA binding
HCU65_18315	COG2059	Chromate
HCU65_18320	COG2059	Chromate
HCU65_18340	COG1515	deoxyribonuclease V activity
HCU65_18345	COG2849	repeat protein
HCU65_18350	COG5444	nuclease activity
HCU65_18370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCU65_18380	COG4464	protein tyrosine phosphatase activity
HCU65_18385	COG0489	protein tyrosine kinase activity
HCU65_18390	COG3944	biosynthesis protein
HCU65_18400	COG4715	Zinc finger, swim domain protein
HCU65_18405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCU65_18410	COG0561	phosphatase activity
HCU65_18415	COG1349	DNA-binding transcription factor activity
HCU65_18420	COG0629	single-stranded DNA binding
HCU65_18435	COG1970	mechanosensitive ion channel activity
HCU65_18445	COG0457	Tetratricopeptide repeat
HCU65_18450	COG4786	Flagellar basal body rod
HCU65_18455	COG4786	Flagellar basal body rod
HCU65_18460	COG1077	Cell shape determining protein MreB Mrl
HCU65_18465	COG1609	Transcriptional regulator
HCU65_18475	COG1846	Transcriptional regulator
HCU65_18480	COG2814	Major facilitator Superfamily
HCU65_18485	COG1953	Uracil, thiamine, allantoin
HCU65_18490	COG0477	Major facilitator Superfamily
HCU65_18495	COG1335	isochorismatase
HCU65_18505	COG0004	ammonium transporteR
HCU65_18510	COG0347	Belongs to the P(II) protein family
HCU65_18515	COG0772	Belongs to the SEDS family
HCU65_18520	COG0671	phosphoesterase, PA-phosphatase related
HCU65_18530	COG0739	heme binding
HCU65_18535	COG1247	-acetyltransferase
HCU65_18545	COG1086	Polysaccharide biosynthesis protein
HCU65_18550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCU65_18555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCU65_18560	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HCU65_18575	COG2089	acid synthase
HCU65_18585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCU65_18590	COG0789	Transcriptional regulator
HCU65_18600	COG2910	NAD(P)H-binding
HCU65_18605	COG1959	2 iron, 2 sulfur cluster binding
HCU65_18610	COG0804	urea catabolic process
HCU65_18620	COG0831	urea catabolic process
HCU65_18625	COG3237	CsbD-like
HCU65_18630	COG1994	Peptidase M50
HCU65_18635	COG0457	Tetratricopeptide repeat
HCU65_18645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HCU65_18655	COG2304	oxidoreductase activity
HCU65_18660	COG2304	oxidoreductase activity
HCU65_18665	COG2385	sporulation resulting in formation of a cellular spore
HCU65_18670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCU65_18680	COG4836	Membrane
HCU65_18690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HCU65_18695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HCU65_18700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HCU65_18710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCU65_18715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HCU65_18735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HCU65_18740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCU65_18745	COG4475	Protein of unknown function (DUF436)
HCU65_18750	COG0698	ribose 5-phosphate isomerase
HCU65_18755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCU65_18760	COG1971	Probably functions as a manganese efflux pump
HCU65_18765	COG0009	L-threonylcarbamoyladenylate synthase
HCU65_18770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HCU65_18790	COG2890	protein-(glutamine-N5) methyltransferase activity
HCU65_18795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HCU65_18800	COG0346	lactoylglutathione lyase activity
HCU65_18805	COG0789	Transcriptional regulator
HCU65_18810	COG0679	Auxin Efflux Carrier
HCU65_18815	COG0281	malic enzyme
HCU65_18825	COG0254	rRNA binding
HCU65_18830	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HCU65_18835	COG1494	fructose-1,6-bisphosphatase
HCU65_18840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCU65_18850	COG0191	fructose-bisphosphate aldolase activity
HCU65_18855	COG2204	response regulator
HCU65_18860	COG4821	SIS domain
HCU65_18865	COG0504	CTP synthase activity
HCU65_18870	COG3343	RNA polymerase activity
HCU65_18875	COG1960	acyl-CoA dehydrogenase activity
HCU65_18880	COG2181	nitrate reductase activity
HCU65_18880	COG0247	lactate metabolic process
HCU65_18885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCU65_18890	COG4294	response to UV
HCU65_18900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HCU65_18905	COG1132	(ABC) transporter
HCU65_18910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCU65_18915	COG2181	nitrate reductase activity
HCU65_18920	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HCU65_18925	COG1140	nitrate reductase beta subunit
HCU65_18930	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HCU65_18935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCU65_18945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCU65_18950	COG2223	nitrite transmembrane transporter activity
HCU65_18955	COG0018	arginyl-trna synthetase
HCU65_18960	COG4506	Protein conserved in bacteria
HCU65_18970	COG0535	radical SAM domain protein
HCU65_18980	COG1131	(ABC) transporter
HCU65_19005	COG3391	amine dehydrogenase activity
HCU65_19010	COG3391	amine dehydrogenase activity
HCU65_19015	COG1388	LysM domain
HCU65_19020	COG0457	Tetratricopeptide repeat
HCU65_19035	COG0010	Belongs to the arginase family
HCU65_19040	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HCU65_19045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCU65_19060	COG1994	Peptidase M50
HCU65_19065	COG1942	4-Oxalocrotonate Tautomerase
HCU65_19070	COG1846	Transcriptional regulator
HCU65_19075	COG0531	amino acid
HCU65_19080	COG3465	dGTPase activity
HCU65_19085	COG1078	dGTPase activity
HCU65_19090	COG4844	belongs to the
HCU65_19100	COG0697	spore germination
HCU65_19110	COG0583	DNA-binding transcription factor activity
HCU65_19120	COG0280	phosphate acetyltransferase
HCU65_19125	COG3253	May function as heme-dependent peroxidase
HCU65_19130	COG2814	Major facilitator Superfamily
HCU65_19135	COG2814	Major facilitator Superfamily
HCU65_19145	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HCU65_19150	COG1091	dTDP-4-dehydrorhamnose reductase activity
HCU65_19155	COG1088	dTDP-glucose 4,6-dehydratase activity
HCU65_19160	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HCU65_19165	COG0456	acetyltransferase
HCU65_19170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCU65_19175	COG0463	Glycosyl transferase, family 2
HCU65_19185	COG2363	Small membrane protein
HCU65_19190	COG2233	PERMEase
HCU65_19200	COG1012	belongs to the aldehyde dehydrogenase family
HCU65_19205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HCU65_19210	COG1216	Glycosyl transferase, family 2
HCU65_19225	COG1695	Transcriptional regulator
HCU65_19230	COG0351	phosphomethylpyrimidine kinase
HCU65_19240	COG0110	maltose O-acetyltransferase activity
HCU65_19245	COG1621	beta-fructofuranosidase activity
HCU65_19250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU65_19250	COG1263	PTS System
HCU65_19260	COG3711	transcriptional antiterminator
HCU65_19270	COG1404	Belongs to the peptidase S8 family
HCU65_19280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCU65_19285	COG0778	Nitroreductase
HCU65_19290	COG0772	Belongs to the SEDS family
HCU65_19305	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HCU65_19315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCU65_19320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCU65_19325	COG2261	transglycosylase associated protein
HCU65_19330	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HCU65_19335	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HCU65_19340	COG2246	polysaccharide biosynthetic process
HCU65_19345	COG1309	transcriptional regulator
HCU65_19365	COG3162	membrane
HCU65_19370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCU65_19375	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HCU65_19380	COG0352	thiamine-phosphate diphosphorylase activity
HCU65_19385	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HCU65_19390	COG0583	DNA-binding transcription factor activity
HCU65_19400	COG1346	cytolysis
HCU65_19405	COG1131	(ABC) transporter
HCU65_19420	COG1346	cytolysis
HCU65_19425	COG4895	conserved protein (DUF2196)
HCU65_19430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HCU65_19435	COG0346	lactoylglutathione lyase activity
HCU65_19440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCU65_19445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU65_19445	COG1263	PTS System
HCU65_19450	COG3711	transcriptional antiterminator
HCU65_19455	COG1442	glycosyl transferase family 8
HCU65_19460	COG5522	Integral membrane protein (intg_mem_TP0381)
HCU65_19465	COG2234	aminopeptidase activity
HCU65_19470	COG0457	Tetratricopeptide repeat
HCU65_19475	COG1846	Transcriptional regulator
HCU65_19480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCU65_19485	COG2357	RelA SpoT domain protein
HCU65_19490	COG1575	Belongs to the MenA family. Type 1 subfamily
HCU65_19495	COG0569	domain protein
HCU65_19505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCU65_19510	COG1696	Membrane protein involved in D-alanine export
HCU65_19520	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HCU65_19525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCU65_19530	COG1486	melibiose metabolic process
HCU65_19535	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCU65_19540	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCU65_19545	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCU65_19550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU65_19550	COG3711	transcriptional antiterminator
HCU65_19560	COG2094	Belongs to the DNA glycosylase MPG family
HCU65_19565	COG0753	catalase activity
HCU65_19570	COG2814	Major facilitator Superfamily
HCU65_19575	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HCU65_19580	COG1131	(ABC) transporter
HCU65_19600	COG1595	DNA-templated transcription, initiation
HCU65_19605	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HCU65_19610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HCU65_19615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HCU65_19620	COG4988	ABC transporter
HCU65_19625	COG1294	oxidase, subunit
HCU65_19630	COG1271	oxidase subunit
HCU65_19635	COG3493	citrate carrier protein
HCU65_19645	COG0726	polysaccharide deacetylase
HCU65_19650	COG3842	ATPase activity
HCU65_19655	COG2508	Transcriptional regulator
HCU65_19660	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCU65_19670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCU65_19680	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCU65_19690	COG4894	glucomannan catabolic process
HCU65_19695	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCU65_19700	COG3829	transcription factor binding
HCU65_19700	COG3290	protein histidine kinase activity
HCU65_19705	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_19710	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HCU65_19715	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HCU65_19720	COG2610	gluconate transmembrane transporter activity
HCU65_19725	COG0500	methyltransferase
HCU65_19730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCU65_19745	COG0753	catalase activity
HCU65_19745	COG0693	protein deglycase activity
HCU65_19750	COG2851	Citrate transporter
HCU65_19760	COG3711	transcriptional antiterminator
HCU65_19770	COG2270	Major facilitator Superfamily
HCU65_19775	COG0513	Belongs to the DEAD box helicase family
HCU65_19780	COG0346	lactoylglutathione lyase activity
HCU65_19785	COG1357	PFAM Pentapeptide repeats (8 copies)
HCU65_19790	COG2755	lipolytic protein G-D-S-L family
HCU65_19790	COG3401	FG-GAP repeat protein
HCU65_19850	COG3866	Pectate lyase
HCU65_19855	COG0697	spore germination
HCU65_19870	COG0697	spore germination
HCU65_19890	COG2723	6-phospho-beta-galactosidase activity
HCU65_19895	COG1263	PTS System
HCU65_19895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU65_19895	COG2190	(PTS) system
HCU65_19915	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCU65_19945	COG5444	nuclease activity
HCU65_19960	COG3507	Belongs to the glycosyl hydrolase 43 family
HCU65_19970	COG2986	histidine ammonia-lyase
HCU65_19975	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HCU65_19980	COG1228	amidohydrolase
HCU65_19985	COG0010	Belongs to the arginase family
HCU65_19990	COG0833	amino acid
HCU65_19995	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HCU65_20000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCU65_20005	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HCU65_20010	COG2390	Transcriptional regulator
HCU65_20020	COG3192	ethanolamine utilization protein
HCU65_20025	COG1940	carbohydrate kinase activity
HCU65_20030	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HCU65_20035	COG0561	phosphatase activity
HCU65_20060	COG5294	Protein conserved in bacteria
HCU65_20065	COG0577	efflux transmembrane transporter activity
HCU65_20070	COG1136	(ABC) transporter
HCU65_20075	COG2205	protein histidine kinase activity
HCU65_20080	COG0745	RESPONSE REGULATOR receiver
HCU65_20090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCU65_20105	COG1082	Xylose isomerase domain protein TIM barrel
HCU65_20110	COG0673	inositol 2-dehydrogenase activity
HCU65_20115	COG2814	Major facilitator Superfamily
HCU65_20120	COG1082	Xylose isomerase domain protein TIM barrel
HCU65_20125	COG3962	Belongs to the TPP enzyme family
HCU65_20130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCU65_20145	COG1349	DNA-binding transcription factor activity
HCU65_20150	COG0667	Aldo Keto reductase
HCU65_20170	COG2814	Major facilitator Superfamily
HCU65_20175	COG0326	Molecular chaperone. Has ATPase activity
HCU65_20180	COG1028	Short-chain dehydrogenase reductase Sdr
HCU65_20185	COG1309	transcriptional regulator
HCU65_20190	COG1012	belongs to the aldehyde dehydrogenase family
HCU65_20200	COG1714	RDD family
HCU65_20205	COG2311	Membrane
HCU65_20210	COG1917	Cupin 2, conserved barrel domain protein
HCU65_20215	COG1309	transcriptional regulator
HCU65_20230	COG5039	Polysaccharide pyruvyl transferase
HCU65_20235	COG1929	Belongs to the glycerate kinase type-1 family
HCU65_20240	COG2610	gluconate transmembrane transporter activity
HCU65_20245	COG3835	regulator
HCU65_20250	COG1802	Transcriptional regulator
HCU65_20255	COG1070	Carbohydrate kinase
HCU65_20260	COG2610	gluconate transmembrane transporter activity
HCU65_20265	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HCU65_20270	COG0450	alkyl hydroperoxide reductase
HCU65_20275	COG3634	alkyl hydroperoxide reductase activity
HCU65_20285	COG1113	amino acid transport
HCU65_20305	COG1131	(ABC) transporter
HCU65_20310	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HCU65_20340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HCU65_20350	COG1063	alcohol dehydrogenase
HCU65_20365	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HCU65_20370	COG0456	acetyltransferase
HCU65_20375	COG0010	Belongs to the arginase family
HCU65_20380	COG0833	amino acid
HCU65_20385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCU65_20390	COG5658	integral membrane protein
HCU65_20395	COG0640	Transcriptional regulator
HCU65_20400	COG3829	transcription factor binding
HCU65_20410	COG0488	(ABC) transporter
HCU65_20425	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HCU65_20435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCU65_20440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HCU65_20445	COG4853	Protein conserved in bacteria
HCU65_20450	COG4863	YycH protein
HCU65_20455	COG5002	protein histidine kinase activity
HCU65_20460	COG0745	RESPONSE REGULATOR receiver
HCU65_20490	COG0346	lactoylglutathione lyase activity
HCU65_20495	COG0305	Participates in initiation and elongation during chromosome replication
HCU65_20510	COG3093	addiction module antidote protein HigA
HCU65_20515	COG2807	transmembrane transport
HCU65_20520	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HCU65_20525	COG0359	binds to the 23S rRNA
HCU65_20530	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HCU65_20535	COG4241	membrane
HCU65_20545	COG5577	PFAM Coat F domain
HCU65_20550	COG1733	regulation of RNA biosynthetic process
HCU65_20565	COG2271	Major facilitator Superfamily
HCU65_20570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCU65_20590	COG5444	nuclease activity
HCU65_20600	COG0473	3-isopropylmalate dehydrogenase activity
HCU65_20605	COG1802	Transcriptional regulator
HCU65_20610	COG0789	Transcriptional regulator
HCU65_20610	COG4978	Transcriptional regulator
HCU65_20620	COG0745	RESPONSE REGULATOR receiver
HCU65_20625	COG2205	protein histidine kinase activity
HCU65_20635	COG1331	Highly conserved protein containing a thioredoxin domain
HCU65_20645	COG0542	response to heat
HCU65_20655	COG1331	Highly conserved protein containing a thioredoxin domain
HCU65_20660	COG0477	Major facilitator Superfamily
HCU65_20660	COG2814	Major facilitator Superfamily
HCU65_20665	COG0346	lactoylglutathione lyase activity
HCU65_20670	COG1609	Transcriptional regulator
HCU65_20675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCU65_20680	COG2169	Transcriptional regulator
HCU65_20685	COG0708	Exodeoxyribonuclease III
HCU65_20690	COG0697	spore germination
HCU65_20695	COG1802	Transcriptional regulator
HCU65_20710	COG0629	single-stranded DNA binding
HCU65_20715	COG0360	Binds together with S18 to 16S ribosomal RNA
HCU65_20720	COG0012	GTP binding
HCU65_20725	COG0243	molybdopterin cofactor binding
HCU65_20730	COG4481	Protein conserved in bacteria
HCU65_20735	COG3949	Membrane
HCU65_20745	COG1475	DNA binding
HCU65_20750	COG1192	Involved in chromosome partitioning
HCU65_20760	COG1475	DNA binding
HCU65_20765	COG0357	Ribosomal RNA small subunit methyltransferase G
HCU65_20770	COG0445	tRNA wobble uridine modification
HCU65_20780	COG1847	R3H domain protein
HCU65_20785	COG0706	membrane insertase activity
HCU65_20790	COG0594	ribonuclease P activity