locus-tag class description BBEV_0003 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BBEV_0004 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BBEV_0006 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BBEV_0008 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein BBEV_0009 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BBEV_0010 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BBEV_0013 ENOG4107QJE Chromosome Partitioning Protein BBEV_0015 ENOG4105FA0 parb-like partition protein BBEV_0016 ENOG4105C3J Cysteine desulfurase BBEV_0017 ENOG4108UQV Membrane BBEV_0018 ENOG4105VDK protein, conserved in bacteria BBEV_0019 ENOG4105C3G gtp-binding protein BBEV_0020 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BBEV_0021 ENOG4108UUM single-stranded DNA-binding protein BBEV_0022 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BBEV_0023 ENOG4108XMW Membrane BBEV_0024 ENOG4105BZR domain protein BBEV_0025 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BBEV_0026 ENOG4105CDU Replicative dna helicase BBEV_0027 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BBEV_0035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BBEV_0036 ENOG4105BZU Histidine kinase BBEV_0039 ENOG4105Q2H domain protein BBEV_0040 ENOG4105C0H protease BBEV_0042 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BBEV_0043 ENOG4107SVH Potassium channel protein BBEV_0045 ENOG4105C1B dTDP-glucose 4-6-dehydratase BBEV_0047 ENOG4105FE9 pseudouridine synthase BBEV_0048 ENOG4105DWT malate dehydrogenase (quinone) BBEV_0051 ENOG4105CJ1 ABC, transporter BBEV_0053 ENOG4105ECK Fatty Acid Desaturase BBEV_0054 ENOG4108ZGX Histidine kinase BBEV_0055 ENOG4108S01 response regulator BBEV_0056 ENOG4105BZU Histidine kinase BBEV_0058 ENOG4105BZ8 glutamate synthase BBEV_0060 ENOG4105KHC sulfurtransferase BBEV_0061 ENOG4108RSN SNARE associated Golgi BBEV_0062 ENOG4105VNH ABC transporter solute-binding protein BBEV_0065 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BBEV_0067 ENOG4108JQ7 (ABC) transporter BBEV_0069 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BBEV_0070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BBEV_0071 ENOG4105DEF Extracellular solute-binding protein, family 5 BBEV_0072 ENOG4105CFH Aspartokinase BBEV_0075 ENOG4108X4Q Hydrolase BBEV_0076 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BBEV_0077 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BBEV_0080 ENOG4107QJZ Glycosyl transferase, family 2 BBEV_0083 ENOG4105DR4 Methyltransferase BBEV_0084 ENOG4105CX6 glutaminyL-tRNA synthetase BBEV_0090 ENOG4105CS9 pantothenic acid kinase BBEV_0091 ENOG4105KME endoribonuclease L-psp BBEV_0092 ENOG4105DWD nucleoside recognition domain protein BBEV_0094 ENOG4105E0M Sulfatase BBEV_0096 ENOG4108TN2 lmbE family BBEV_0099 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BBEV_0101 ENOG4105D7K pfkb domain protein BBEV_0103 ENOG4107YTP response regulator receiver protein BBEV_0104 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BBEV_0105 ENOG4105BZU Histidine kinase BBEV_0106 ENOG4105K4T epimerase BBEV_0110 ENOG4107JTW chlorite dismutase BBEV_0111 ENOG4108UKI Enoyl-CoA hydratase BBEV_0112 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BBEV_0113 ENOG4108IJ2 phosphate acetyltransferase BBEV_0116 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BBEV_0118 ENOG4105DCI Phosphohydrolase BBEV_0119 ENOG41069HH 4-oxalocrotonate tautomerase BBEV_0120 ENOG4108XFG YwhD family BBEV_0122 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BBEV_0127 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BBEV_0128 ENOG4105C3U ABC transporter BBEV_0129 ENOG4108JQ7 (ABC) transporter BBEV_0132 ENOG4105C75 arginyL-tRNA synthetase BBEV_0133 ENOG4105C8Q Methyl-accepting chemotaxis BBEV_0134 ENOG4105MVE transcriptional regulator BBEV_0135 ENOG4105G63 Type III effector Hrp-dependent BBEV_0136 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BBEV_0137 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BBEV_0139 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter BBEV_0140 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BBEV_0141 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BBEV_0142 ENOG4105DVE abc transporter atp-binding protein BBEV_0144 ENOG4105BZ1 (ABC) transporter BBEV_0147 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BBEV_0149 ENOG4105DF6 Fe-S oxidoreductase BBEV_0151 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BBEV_0152 ENOG4105C1G acyl-Coa dehydrogenase BBEV_0153 ENOG4105C1G acyl-Coa dehydrogenase BBEV_0155 ENOG4105D5P Methylmalonyl-coA mutase BBEV_0156 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) BBEV_0157 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BBEV_0159 ENOG410812K response regulator receiver protein BBEV_0161 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BBEV_0162 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BBEV_0163 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BBEV_0164 ENOG41081WG 50s ribosomal protein l31 BBEV_0165 ENOG4107104 thymidine kinase BBEV_0166 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BBEV_0167 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BBEV_0168 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BBEV_0169 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BBEV_0170 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BBEV_0173 ENOG4105C8Q Methyl-accepting chemotaxis BBEV_0174 ENOG4108YZG isomerase BBEV_0176 ENOG4105BZU Histidine kinase BBEV_0177 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BBEV_0178 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BBEV_0179 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BBEV_0182 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) BBEV_0185 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BBEV_0186 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BBEV_0187 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BBEV_0188 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BBEV_0189 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BBEV_0191 ENOG4105D4B ABC, transporter BBEV_0192 ENOG4105C2F Histidine kinase BBEV_0193 ENOG410874W AraC family transcriptional regulator BBEV_0194 ENOG4105DFW ABC transporter BBEV_0195 ENOG4105C2J ABC transporter BBEV_0196 ENOG4108HWW ABC transporter BBEV_0198 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BBEV_0199 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BBEV_0200 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BBEV_0201 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) BBEV_0202 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BBEV_0203 ENOG4107UFS subunit j BBEV_0204 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BBEV_0205 ENOG4105D65 subunit l BBEV_0206 ENOG4105C8S subunit m BBEV_0207 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BBEV_0210 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BBEV_0211 ENOG4105DFF Rod shape-determining protein mreb BBEV_0213 ENOG4105CGA flagellar basal-body rod protein FlgG BBEV_0224 ENOG4105Z8B NlpC/P60 family BBEV_0225 ENOG4108KGH TRANSCRIPTIONal BBEV_0228 ENOG4105PNM synthesis protein BBEV_0232 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) BBEV_0233 ENOG4108DBC nitroreductase BBEV_0240 ENOG4105D7K pfkb domain protein BBEV_0241 ENOG4108VA3 3-hexulose-6-phosphate synthase BBEV_0243 ENOG4108UHU Aldolase BBEV_0246 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BBEV_0250 ENOG4105HTX biosynthesis protein BBEV_0251 ENOG4107YJ4 chain length determinant protein BBEV_0253 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BBEV_0256 ENOG4105D3Q Sugar transferase BBEV_0257 ENOG4105EXW epimerase dehydratase BBEV_0271 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BBEV_0281 ENOG4108KGH TRANSCRIPTIONal BBEV_0285 ENOG4105K4I Scp-like extracellular BBEV_0286 ENOG4105JFG SpoIID LytB domain protein BBEV_0290 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BBEV_0295 ENOG4105K64 Glycosyl transferase, family 2 BBEV_0298 ENOG4105EY8 ABC transporter BBEV_0302 ENOG4105ESV Glycosyl transferase, family 4 BBEV_0303 ENOG4105JFG SpoIID LytB domain protein BBEV_0304 ENOG4108KGH TRANSCRIPTIONal BBEV_0305 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BBEV_0308 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BBEV_0309 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BBEV_0318 ENOG4106F1P AAA ATPase, central domain protein BBEV_0319 ENOG4108IUM Glycogen debranching enzyme BBEV_0320 ENOG4105CGH 5'-nucleotidase BBEV_0324 ENOG4105E66 phosphoriboisomerase A BBEV_0328 ENOG4105VZ8 Transcriptional regulator BBEV_0334 ENOG4108J2R molybdopterin oxidoreductase BBEV_0337 ENOG4107QY8 reductase BBEV_0338 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BBEV_0348 ENOG4105Z8B NlpC/P60 family BBEV_0349 ENOG4108JE9 extracellular solute-binding protein family 1 BBEV_0353 ENOG4105N98 Capsule biosynthesis protein capB BBEV_0354 ENOG4105DXI Major Facilitator superfamily BBEV_0357 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BBEV_0361 ENOG4105DRS transport system, permease BBEV_0363 ENOG41075H3 AraC family transcriptional regulator BBEV_0365 ENOG4105D17 glycoside hydrolase, family 3 domain protein BBEV_0369 ENOG4105BZU Histidine kinase BBEV_0370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BBEV_0374 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BBEV_0377 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) BBEV_0379 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC BBEV_0380 ENOG410667J hydrolase BBEV_0381 ENOG4108RPX mosc domain containing protein BBEV_0383 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BBEV_0387 ENOG4107YHD transcriptional regulator BBEV_0389 ENOG4105ETE Transcriptional regulator (LacI family BBEV_0390 ENOG4108RVA ribokinase BBEV_0391 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BBEV_0392 ENOG4105CNN ABC, transporter BBEV_0393 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BBEV_0399 ENOG4108IUM Glycogen debranching enzyme BBEV_0400 ENOG4105BZU Histidine kinase BBEV_0408 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein BBEV_0409 ENOG4105E98 transcriptional regulator DeoR family BBEV_0410 ENOG4105DE4 1-phosphofructokinase BBEV_0411 ENOG4105DM4 PTS System BBEV_0413 ENOG4105BZU Histidine kinase BBEV_0415 ENOG4105BZU Histidine kinase BBEV_0416 ENOG4105JSC dimethylmenaquinone methyltransferase BBEV_0418 ENOG4105CJ1 ABC, transporter BBEV_0419 ENOG4108TU7 Inherit from COG: (ABC) transporter BBEV_0421 ENOG4105CMT Dihydroxyacetone kinase BBEV_0422 ENOG4108UTZ Dihydroxyacetone kinase BBEV_0423 ENOG4105VDH Dihydroxyacetone kinase BBEV_0425 ENOG4105CMT Dihydroxyacetone kinase BBEV_0427 ENOG4105CHR reductase BBEV_0428 ENOG4105C0D helicase BBEV_0430 ENOG4108JUB Transcriptional regulator BBEV_0431 ENOG4105DYB Isoaspartyl dipeptidase BBEV_0432 ENOG4108JQ7 (ABC) transporter BBEV_0433 ENOG4105C3U ABC transporter BBEV_0434 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BBEV_0436 ENOG4105DEF Extracellular solute-binding protein, family 5 BBEV_0438 ENOG4108PJD permease BBEV_0441 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BBEV_0442 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BBEV_0444 ENOG4105HMI Membrane BBEV_0445 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BBEV_0447 ENOG4105DRR Transcriptional regulator, GntR family BBEV_0457 ENOG4107EFR Flavocytochrome c BBEV_0458 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BBEV_0459 ENOG4105C26 Dehydrogenase BBEV_0460 ENOG4108V06 Glutathione peroxidase BBEV_0461 ENOG4105C26 Dehydrogenase BBEV_0462 ENOG4105DAA L-lactate BBEV_0464 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BBEV_0465 ENOG4105BZU Histidine kinase BBEV_0471 ENOG4105I82 acetyl xylan esterase BBEV_0474 ENOG4105DG6 mannose-6-phosphate isomerase BBEV_0475 ENOG4105P4J Allophanate hydrolase, subunit 1 BBEV_0476 ENOG4105E7W lamb ycsf family protein BBEV_0477 ENOG4107R7A Allophanate hydrolase subunit 2 BBEV_0479 ENOG4108VPT UPF0234 protein BBEV_0485 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BBEV_0490 ENOG4105DER m42 family BBEV_0492 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BBEV_0493 ENOG4105CK7 Sodium proline symporter BBEV_0494 ENOG4105DFD Na H antiporter BBEV_0496 ENOG4105DHP deoxycytidine triphosphate deaminase BBEV_0498 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BBEV_0501 ENOG4105EPR degv family BBEV_0503 ENOG41081UC Inherit from COG: Competence protein BBEV_0504 ENOG4105RU3 BBEV_0507 ENOG4105E1Q flagellar hook-associated protein BBEV_0508 ENOG4105DTJ flagellar hook-associated protein BBEV_0510 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BBEV_0511 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BBEV_0513 ENOG4105I03 Flagellin BBEV_0515 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BBEV_0516 ENOG4105I03 Flagellin BBEV_0518 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 BBEV_0527 ENOG4107QW4 alcohol dehydrogenase BBEV_0529 ENOG4107U9T Pfam:Ribonuclease_BN BBEV_0530 ENOG4105E5G Alpha beta hydrolase fold BBEV_0533 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BBEV_0535 ENOG4105CPI Metal Dependent Phosphohydrolase BBEV_0536 ENOG4105BZU Histidine kinase BBEV_0537 ENOG4107RT6 flagellar hook-associated BBEV_0538 ENOG4107RT6 flagellar hook-associated BBEV_0539 ENOG41069ZS flagellar protein BBEV_0540 ENOG41083S7 flagellar protein FlaG BBEV_0541 ENOG4105MQ3 flagellar protein FliS BBEV_0546 ENOG4105VEQ Cold shock protein BBEV_0547 ENOG4105MS2 ribosomal subunit Interface protein BBEV_0549 ENOG4105CID antiterminator BBEV_0550 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BBEV_0551 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BBEV_0554 ENOG4105CAK Cell division ATP-binding protein ftsE BBEV_0555 ENOG4105CRP Part of the ABC transporter FtsEX involved in BBEV_0556 ENOG4105Z8B NlpC/P60 family BBEV_0557 ENOG4105CN1 protease BBEV_0559 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BBEV_0560 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BBEV_0561 ENOG4108PY7 BBEV_0562 ENOG41067S9 phage shock protein C, PspC BBEV_0563 ENOG41086DT Membrane protein of unknown function BBEV_0564 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BBEV_0565 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BBEV_0566 ENOG4105HKU nucleoside recognition domain-containing protein BBEV_0567 ENOG4107XGZ Hydrolase BBEV_0568 ENOG4108S4C acetyltransferase BBEV_0569 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BBEV_0570 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BBEV_0571 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BBEV_0572 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BBEV_0573 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BBEV_0574 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BBEV_0575 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BBEV_0576 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BBEV_0577 ENOG4105EWK phytoene BBEV_0579 ENOG4105C3M thioredoxin reductase BBEV_0580 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BBEV_0581 ENOG4105CHW UPF0052 protein BBEV_0582 ENOG4105CIE May be required for sporulation (By similarity) BBEV_0583 ENOG4105KRI phosphocarrier protein (HPr BBEV_0584 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BBEV_0585 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BBEV_0587 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BBEV_0589 ENOG4105CP7 Triose-phosphate isomerase BBEV_0590 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BBEV_0591 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BBEV_0592 ENOG4105CK5 oxidoreductase BBEV_0593 ENOG4105XZU Preprotein translocase, subunit SecG BBEV_0596 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BBEV_0597 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BBEV_0598 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BBEV_0599 ENOG4105C01 Dihydroxy-acid dehydratase BBEV_0603 ENOG4105BZU Histidine kinase BBEV_0604 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BBEV_0606 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BBEV_0608 ENOG4105CHU acetyl-coa acetyltransferase BBEV_0609 ENOG4105C1G acyl-Coa dehydrogenase BBEV_0611 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BBEV_0613 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BBEV_0614 ENOG4108UMI ABC transporter, permease BBEV_0615 ENOG4105D01 (LipO)protein BBEV_0619 ENOG4105C3K feS assembly ATPase SufC BBEV_0620 ENOG4105JRK feS assembly protein SufD BBEV_0622 ENOG4108UNV SUF system FeS assembly protein, NifU family BBEV_0623 ENOG4105DIW FeS assembly protein SUFB BBEV_0624 ENOG4105I3N Conserved Protein BBEV_0626 ENOG4107R8B 5'-nucleotidase BBEV_0627 ENOG4105CPI Metal Dependent Phosphohydrolase BBEV_0628 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BBEV_0629 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BBEV_0630 ENOG4107S6Z Na H antiporter BBEV_0632 ENOG4105MMD transcriptional regulator BBEV_0634 ENOG4105CBT Fructose-1,6-bisphosphatase BBEV_0637 ENOG4105D4U had-superfamily hydrolase, subfamily iia BBEV_0638 ENOG4105C5I Dehydrogenase BBEV_0639 ENOG41083MR nifu domain-containing protein BBEV_0644 ENOG4105DVY radical SAM domain protein BBEV_0645 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BBEV_0646 ENOG4105CAY ferredoxin--nadp reductase BBEV_0647 ENOG4105CEP NADH dehydrogenase BBEV_0652 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BBEV_0653 ENOG4108KJ1 Trap dicarboxylate transporter, dctp subunit BBEV_0675 ENOG4105BZJ Electron transfer flavoprotein BBEV_0676 ENOG4105C10 Electron transfer flavoprotein BBEV_0677 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase BBEV_0678 ENOG41090P5 ferredoxin-like protein BBEV_0679 ENOG4108ZB6 transcriptional regulator AsnC family BBEV_0680 ENOG4105CHM Aminotransferase BBEV_0682 ENOG4107QYV phosphohexose isomerase BBEV_0686 ENOG4105VTR Integrase BBEV_0687 ENOG4105E5H Transposase BBEV_0697 ENOG4105DZR Type I site-specific deoxyribonuclease BBEV_0700 ENOG4105C8Q Methyl-accepting chemotaxis BBEV_0703 ENOG4105C8J )-transporter BBEV_0706 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BBEV_0707 ENOG4105XTG Pfam:DUF156 BBEV_0709 ENOG4105U0R haloacid dehalogenase-like hydrolase BBEV_0710 ENOG4108JYZ YitT family BBEV_0714 ENOG4108W2P Methyl-accepting chemotaxis BBEV_0715 ENOG4107YZX Universal stress protein BBEV_0716 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BBEV_0718 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BBEV_0721 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BBEV_0722 ENOG4105CVM Molybdenum cofactor synthesis domain protein BBEV_0723 ENOG4105CVM Molybdenum cofactor synthesis domain protein BBEV_0724 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BBEV_0728 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BBEV_0729 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BBEV_0730 ENOG4108Z0R Transferase BBEV_0731 ENOG4105E8V Alpha Beta Hydrolase Fold protein BBEV_0734 ENOG4105N5T Radical SAM Protein BBEV_0735 ENOG4105C8T Leucyl-tRNA synthetase BBEV_0737 ENOG4105CBX hi0933 family BBEV_0738 ENOG4105CBX hi0933 family BBEV_0740 ENOG4105II7 pyrroline-5-carboxylate reductase BBEV_0741 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BBEV_0742 ENOG4105CNI cell division protein FtsW BBEV_0743 ENOG4105CNI cell division protein FtsW BBEV_0745 ENOG4105YW5 deoR family transcriptional regulator BBEV_0752 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BBEV_0754 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BBEV_0755 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BBEV_0756 ENOG4108IUM Glycogen debranching enzyme BBEV_0757 ENOG4108V15 phosphotransferase enzyme family BBEV_0758 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BBEV_0759 ENOG4105C8F Beta-lactamase domain protein BBEV_0761 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BBEV_0764 ENOG4108NKM UPF0354 protein BBEV_0768 ENOG4105DFU Cell wall formation (By similarity) BBEV_0773 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BBEV_0774 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BBEV_0775 ENOG4105ETE Transcriptional regulator (LacI family BBEV_0776 ENOG4105E14 MotA TolQ exbB proton channel BBEV_0777 ENOG4106VK6 Flagellar motor protein BBEV_0778 ENOG4105F1V Acetoin utilization protein BBEV_0779 ENOG4105W87 Cbs domain BBEV_0780 ENOG4105DGU Histone deacetylase BBEV_0785 ENOG4105CIG ABC transporter BBEV_0789 ENOG4105D6J arsenicaL-resistance protein BBEV_0793 ENOG4105C02 permease BBEV_0796 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BBEV_0800 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E BBEV_0803 ENOG4107V6Q Cyclic nucleotide-binding domain BBEV_0805 ENOG4108IUE nitrate reductase beta subunit BBEV_0806 ENOG4105R3A Nitrate reductase BBEV_0808 ENOG4105DQQ Major facilitator superfamily MFS_1 BBEV_0809 ENOG4107R3J Transporter BBEV_0813 ENOG4108W63 CRP FNR family transcriptional regulator BBEV_0815 ENOG4105EAU Plays a role in nitrite reduction (By similarity) BBEV_0818 ENOG4105DA4 cytochrome c-type biogenesis protein BBEV_0822 ENOG4105CJ1 ABC, transporter BBEV_0824 ENOG41060IM Heme exporter protein BBEV_0826 ENOG4107QX9 Thiol disulfide interChange protein BBEV_0827 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BBEV_0828 ENOG4105DWF phosphomethylpyrimidine kinase BBEV_0829 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BBEV_0831 ENOG4105CGK Exodeoxyribonuclease III BBEV_0832 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BBEV_0836 ENOG4105CVR type I restriction-modification system BBEV_0837 ENOG41082EK Restriction modification system DNA (Specificity BBEV_0838 ENOG4105DZR Type I site-specific deoxyribonuclease BBEV_0847 ENOG4108Q5F Tetr family transcriptional regulator BBEV_0857 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BBEV_0858 ENOG4105BZU Histidine kinase BBEV_0860 ENOG4108W76 histidinol phosphate phosphatase hisj family BBEV_0861 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) BBEV_0863 ENOG4105EFZ amidohydrolase BBEV_0865 ENOG4105D07 Signal peptide peptidase, SppA BBEV_0866 ENOG4105VK3 rdd domain containing protein BBEV_0867 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BBEV_0869 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BBEV_0872 ENOG4107YZX Universal stress protein BBEV_0875 ENOG4105DC7 peptidase M24 BBEV_0876 ENOG4105E8R UPF0173 metal-dependent hydrolase BBEV_0880 ENOG4105SFS phosphoesterase RecJ domain protein BBEV_0881 ENOG4105C0B DNA polymerase III (alpha subunit) BBEV_0882 ENOG4105C6K Malic enzyme BBEV_0883 ENOG4107YCY Transcriptional regulator BBEV_0884 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BBEV_0885 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BBEV_0886 ENOG4105CTQ phosphohexokinase BBEV_0887 ENOG4105CA9 Pyruvate kinase BBEV_0888 ENOG4105FS0 cytoplasmic membrane protein BBEV_0889 ENOG4108VMM UPF0756 membrane protein BBEV_0890 ENOG4105BZN citrate synthase BBEV_0891 ENOG4108HMX isocitrate dehydrogenase (NADP) BBEV_0892 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BBEV_0894 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BBEV_0895 ENOG4105BZU Histidine kinase BBEV_0896 ENOG4105C2M dna polymerase I BBEV_0897 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BBEV_0898 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BBEV_0899 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BBEV_0901 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BBEV_0904 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) BBEV_0905 ENOG4105C22 threonyL-tRNA synthetase BBEV_0907 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BBEV_0908 ENOG4105VJV 50s ribosomal protein L35 BBEV_0909 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BBEV_0912 ENOG4108ZGX Histidine kinase BBEV_0913 ENOG4105WH1 Two component transcriptional regulator luxr family BBEV_0914 ENOG4105CJ1 ABC, transporter BBEV_0919 ENOG4105CN9 Peptidase m42 family protein BBEV_0922 ENOG4108RWN rrna methyltransferase BBEV_0923 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BBEV_0924 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BBEV_0929 ENOG4105DCG PHP domain protein BBEV_0930 ENOG4105C98 muts2 protein BBEV_0933 ENOG4105CEY Amp-dependent synthetase and ligase BBEV_0934 ENOG4105CEY Amp-dependent synthetase and ligase BBEV_0935 ENOG4107Z3H Transcriptional regulator, TetR family BBEV_0936 ENOG41060WC Enoyl-CoA hydratase BBEV_0937 ENOG4105BZJ Electron transfer flavoprotein BBEV_0938 ENOG4105C10 Electron transfer flavoprotein BBEV_0939 ENOG4105K63 Thioredoxin BBEV_0940 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BBEV_0944 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BBEV_0946 ENOG4105E33 succinate dehydrogenase BBEV_0948 ENOG4105CID antiterminator BBEV_0949 ENOG4105KRI phosphocarrier protein (HPr BBEV_0950 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BBEV_0951 ENOG41067TZ transcriptional regulator, MarR family BBEV_0954 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BBEV_0955 ENOG4105M59 Phosphodiesterase, mj0936 family BBEV_0958 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BBEV_0959 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BBEV_0961 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BBEV_0962 ENOG4105CDA abc transporter atp-binding protein BBEV_0963 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BBEV_0965 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BBEV_0967 ENOG4105D52 delta-aminolevulinic acid dehydratase BBEV_0968 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BBEV_0973 ENOG4105ENE Histidine kinase BBEV_0974 ENOG4105WH1 Two component transcriptional regulator luxr family BBEV_0975 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BBEV_0976 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BBEV_0977 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BBEV_0981 ENOG4107QHF type ii secretion system protein e BBEV_0982 ENOG4105CZX twitching motility protein BBEV_0986 ENOG4106A3R peptidase BBEV_0991 ENOG4108IJ0 Aspartate ammonia-lyase BBEV_0992 ENOG4108Z03 MAF-like protein BBEV_0993 ENOG4105W5Q DNA repair protein (RadC BBEV_0994 ENOG4105DFF Rod shape-determining protein mreb BBEV_0995 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BBEV_0996 ENOG4105YHC Rod shape-determining protein MreD BBEV_0997 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BBEV_0998 ENOG4107QMS site-determining protein BBEV_0999 ENOG4107T3P ABC, transporter BBEV_1003 ENOG4105C03 ribonuclease BBEV_1004 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BBEV_1005 ENOG4105X36 (ribosomal) protein BBEV_1007 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BBEV_1009 ENOG4105C8U phosphate abc transporter BBEV_1010 ENOG4105E2Z phosphate ABC transporter (Permease BBEV_1011 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BBEV_1012 ENOG4108UTW Plays a role in the regulation of phosphate uptake BBEV_1013 ENOG4105YHS UPF0344 protein BBEV_1014 ENOG4108ZXC Two component transcriptional regulator, luxr family BBEV_1016 ENOG4105C8Q Methyl-accepting chemotaxis BBEV_1018 ENOG4107QY8 reductase BBEV_1019 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BBEV_1023 ENOG4105DCF alanine dehydrogenase BBEV_1026 ENOG4105BZU Histidine kinase BBEV_1027 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BBEV_1028 ENOG4105BZU Histidine kinase BBEV_1033 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BBEV_1034 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BBEV_1037 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BBEV_1039 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BBEV_1043 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BBEV_1044 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BBEV_1045 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BBEV_1046 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BBEV_1047 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BBEV_1048 ENOG4108ZP8 Acetolactate synthase small subunit BBEV_1049 ENOG4105C7K acetolactate synthase BBEV_1050 ENOG4105CM2 brancheD-chain amino acid aminotransferase BBEV_1051 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BBEV_1054 ENOG4107SET aldo keto reductase BBEV_1058 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BBEV_1065 ENOG4105DD7 kinase (PfkB family BBEV_1066 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) BBEV_1068 ENOG4105DVE abc transporter atp-binding protein BBEV_1077 ENOG4106MP8 UPF0754 membrane protein BBEV_1078 ENOG4105WZB UPF0342 protein BBEV_1081 ENOG4107VRP DNA repair exonuclease BBEV_1082 ENOG4106D4I domain protein BBEV_1084 ENOG4105F3H Histidine kinase BBEV_1085 ENOG4105EQI Metal Dependent Phosphohydrolase BBEV_1090 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BBEV_1091 ENOG4105K59 histidine triad (HIT) protein BBEV_1096 ENOG4107QIV Cytochrome c biogenesis protein BBEV_1097 ENOG4105BZ4 penicillin-binding protein BBEV_1098 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BBEV_1099 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BBEV_1100 ENOG4105C1Q protoporphyrinogen oxidase BBEV_1103 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BBEV_1104 ENOG41090I5 UPF0735 ACT domain-containing protein BBEV_1105 ENOG4105CQC Prephenate dehydratase BBEV_1106 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BBEV_1108 ENOG41061AI Protein of unknown function (DUF2905) BBEV_1109 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BBEV_1110 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BBEV_1111 ENOG4105VIE preprotein translocase, subunit YajC BBEV_1114 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BBEV_1115 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BBEV_1116 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BBEV_1117 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BBEV_1119 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BBEV_1120 ENOG4105CUT histidyl-tRNA synthetase BBEV_1121 ENOG4105C9M aspartyl-trna synthetase BBEV_1122 ENOG4105CUZ uba thif-type nad fad binding protein BBEV_1123 ENOG4105DAA L-lactate BBEV_1124 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BBEV_1125 ENOG4107QR9 Iron-sulfur cluster binding protein BBEV_1126 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BBEV_1130 ENOG4105C3J Cysteine desulfurase BBEV_1131 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BBEV_1133 ENOG4105C7H Helicase, RecD TraA family BBEV_1135 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BBEV_1136 ENOG4105VBH UPF0297 protein BBEV_1137 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BBEV_1140 ENOG4108VQJ O-methyltransferase BBEV_1141 ENOG4105XYU peptidase (U32 family) BBEV_1142 ENOG4105CFP Peptidase U32 BBEV_1143 ENOG4105DBI uridine monophosphokinase BBEV_1144 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BBEV_1146 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BBEV_1149 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BBEV_1150 ENOG4105ETE Transcriptional regulator (LacI family BBEV_1151 ENOG4105CG3 alpha amylase, catalytic region BBEV_1152 ENOG4105DSE periplasmic solute binding protein BBEV_1154 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BBEV_1157 ENOG4105E0X reductase BBEV_1159 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BBEV_1161 ENOG4105M6F mutator MutT protein BBEV_1162 ENOG41076HS cation diffusion facilitator family transporter BBEV_1163 ENOG4105DEN Luciferase family BBEV_1167 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BBEV_1169 ENOG4105BZU Histidine kinase BBEV_1171 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BBEV_1173 ENOG4105DF9 Lipoate-protein, ligase BBEV_1176 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BBEV_1177 ENOG4105D3R alkyl hydroperoxide reductase BBEV_1179 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BBEV_1180 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BBEV_1181 ENOG4105DJ4 phosphatidylserine decarboxylase BBEV_1183 ENOG4105CQB FAD linked oxidase domain protein BBEV_1184 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BBEV_1186 ENOG4105KJM monovalent cation h antiporter subunit g BBEV_1187 ENOG4105W4C monovalent cation H antiporter subunit F BBEV_1188 ENOG4105SC1 monovalent cation H antiporter subunit E BBEV_1189 ENOG4108JPZ Monovalent cation H antiporter subunit D BBEV_1190 ENOG4105MKQ Monovalent cation H antiporter subunit C BBEV_1191 ENOG4105GND monovalent cation H antiporter subunit B BBEV_1192 ENOG4105D65 subunit l BBEV_1193 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BBEV_1194 ENOG4105CQW ribosome biogenesis GTPase YqeH BBEV_1196 ENOG410812S Rna-binding protein BBEV_1197 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BBEV_1198 ENOG4108WF2 Metal Dependent Phosphohydrolase BBEV_1199 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) BBEV_1200 ENOG4105DXX methyltransferase BBEV_1201 ENOG4105KQC Competence protein BBEV_1202 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BBEV_1204 ENOG4105TQK DNA polymerase iii, delta' subunit BBEV_1205 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BBEV_1206 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BBEV_1207 ENOG4105CSA Coproporphyrinogen iii oxidase BBEV_1208 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BBEV_1209 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BBEV_1210 ENOG4105CFG Acts as a chaperone (By similarity) BBEV_1211 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BBEV_1212 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BBEV_1213 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BBEV_1214 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BBEV_1215 ENOG4105VCC 30S ribosomal protein S21 BBEV_1216 ENOG4105KTH gatB Yqey BBEV_1217 ENOG4105F7J membrane-bound serine protease BBEV_1218 ENOG4105DI5 UPF0365 protein BBEV_1220 ENOG4105C9A Phoh family BBEV_1221 ENOG4105CTJ Metal Dependent Phosphohydrolase BBEV_1223 ENOG4107YR5 Diacylglycerol kinase BBEV_1224 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BBEV_1225 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) BBEV_1226 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BBEV_1227 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BBEV_1229 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BBEV_1231 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BBEV_1232 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BBEV_1237 ENOG4105EGD dinuclear metal center protein, YbgI family BBEV_1238 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BBEV_1239 ENOG4108VJ1 Transcriptional regulator (CarD family BBEV_1241 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BBEV_1242 ENOG4105DIK (ABC) transporter BBEV_1243 ENOG4105CC5 ABC transporter BBEV_1245 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BBEV_1247 ENOG4105FDK ABC transporter BBEV_1248 ENOG4105FAV ABC, transporter BBEV_1249 ENOG4105FAV ABC, transporter BBEV_1250 ENOG4105N80 Ferric uptake regulator, Fur family BBEV_1251 ENOG4108U5J '-nucleotidase BBEV_1252 ENOG4105PTM secreted protein BBEV_1259 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BBEV_1260 ENOG4107RF6 penicillin-binding protein BBEV_1263 ENOG4105EQI Metal Dependent Phosphohydrolase BBEV_1264 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BBEV_1265 ENOG4105D06 uba thif-type nad fad binding protein BBEV_1267 ENOG4107ZXI Rhomboid family BBEV_1270 ENOG4105DKQ ROK family BBEV_1271 ENOG4108T5I Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BBEV_1272 ENOG4105C4B ABC transporter, permease BBEV_1277 ENOG4105C5X domain protein BBEV_1283 ENOG4106855 Competence protein BBEV_1288 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BBEV_1290 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BBEV_1291 ENOG4105WZW rhodanese family BBEV_1292 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BBEV_1294 ENOG4105KST dependent repressor BBEV_1297 ENOG4105DC7 peptidase M24 BBEV_1298 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BBEV_1302 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BBEV_1303 ENOG4108ZSR alkaline shock protein BBEV_1304 ENOG4105M7K Involved in the transcription termination process (By similarity) BBEV_1306 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BBEV_1310 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BBEV_1311 ENOG4105DX0 Hemolysin A BBEV_1312 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BBEV_1313 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BBEV_1316 ENOG4108JUB Transcriptional regulator BBEV_1322 ENOG4105CPP Dehydrogenase, E1 component BBEV_1323 ENOG4105C7S Dehydrogenase BBEV_1328 ENOG4108QEG Membrane BBEV_1330 ENOG4108ZVT methylmalonyl-coA epimerase BBEV_1331 ENOG4108HNZ carboxyl transferase BBEV_1332 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BBEV_1335 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BBEV_1337 ENOG4105VM1 flagellar BBEV_1340 ENOG4105XVJ Protein of unknown function (DUF327) BBEV_1341 ENOG4107RK0 Sucrose phosphorylase BBEV_1342 ENOG4105ETE Transcriptional regulator (LacI family BBEV_1345 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BBEV_1349 ENOG4105V75 Transcriptional regulator BBEV_1352 ENOG4105II7 pyrroline-5-carboxylate reductase BBEV_1353 ENOG4108IXY short-chain dehydrogenase reductase BBEV_1355 ENOG4105KJF protein tyrosine phosphatase BBEV_1357 ENOG4105WE2 aldehyde ferredoxin oxidoreductase BBEV_1362 ENOG4105FE1 phytoene synthase BBEV_1367 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BBEV_1368 ENOG410667J hydrolase BBEV_1369 ENOG4105C5Y PTS System BBEV_1370 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BBEV_1371 ENOG4107ZT5 Thiol disulfide interchange protein BBEV_1372 ENOG4105CPC Aldo Keto reductase BBEV_1373 ENOG4108YZ4 nudix hydrolase BBEV_1374 ENOG4105I3K Ferric uptake regulator, Fur family BBEV_1375 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BBEV_1376 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BBEV_1379 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BBEV_1380 ENOG4107ZE5 PPIases accelerate the folding of proteins BBEV_1386 ENOG4108R6K riboflavin synthase, subunit alpha BBEV_1387 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BBEV_1388 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BBEV_1390 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BBEV_1391 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BBEV_1396 ENOG4105FE9 pseudouridine synthase BBEV_1397 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BBEV_1398 ENOG4107TWT Cytochrome c biogenesis protein BBEV_1399 ENOG4105CRE cytochrome C BBEV_1400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BBEV_1401 ENOG4105BZU Histidine kinase BBEV_1402 ENOG4105EPU Molybdenum cofactor synthesis domain protein BBEV_1403 ENOG4108WBT adenosyltransferase BBEV_1404 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BBEV_1405 ENOG4108JQ1 Dehydrogenase BBEV_1406 ENOG4105JXH GntR family transcriptional regulator BBEV_1409 ENOG4105T7X BBEV_1418 ENOG4108XDN Transcriptional regulator BBEV_1420 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BBEV_1421 ENOG4105HDK L-asparaginase BBEV_1422 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) BBEV_1426 ENOG4105F6E Acyl-transferase BBEV_1430 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BBEV_1431 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BBEV_1435 ENOG4105EUJ GTP cyclohydrolase i BBEV_1436 ENOG4105WP2 Tryptophan RNA-binding attenuator protein BBEV_1437 ENOG4105XXQ heptaprenyl diphosphate synthase component I BBEV_1438 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BBEV_1439 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) BBEV_1440 ENOG4105EV6 Pfam:DUF178 BBEV_1441 ENOG4105EAH synthase BBEV_1442 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BBEV_1443 ENOG4105BZU Histidine kinase BBEV_1445 ENOG4105D49 3-dehydroquinate synthase BBEV_1446 ENOG4105KHN chorismate mutase BBEV_1448 ENOG4108I0Q anthranilate phosphoribosyltransferase BBEV_1449 ENOG4105DK0 Indole-3-glycerol phosphate synthase BBEV_1450 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BBEV_1451 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BBEV_1452 ENOG4105CIH Imidazole acetol-phosphate transaminase BBEV_1459 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BBEV_1463 ENOG4108JYZ YitT family BBEV_1464 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BBEV_1465 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BBEV_1466 ENOG4108Z5K methylglyoxal synthase BBEV_1467 ENOG4105FJR Lmbe family BBEV_1468 ENOG4105CPK Glycosyl transferase (Group 1 BBEV_1469 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BBEV_1471 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BBEV_1472 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BBEV_1473 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BBEV_1474 ENOG4105DVT helicase BBEV_1475 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BBEV_1477 ENOG4105CHM Aminotransferase BBEV_1478 ENOG4105C5S asparaginyl-tRNA synthetase BBEV_1480 ENOG4105CSM endonuclease III BBEV_1481 ENOG4105BZ4 penicillin-binding protein BBEV_1482 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BBEV_1488 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BBEV_1492 ENOG410905X membrane-flanked domain protein BBEV_1493 ENOG4105CKV Membrane BBEV_1497 ENOG4105BZU Histidine kinase BBEV_1503 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BBEV_1505 ENOG4105ZMH deoxynucleoside kinase BBEV_1510 ENOG4108NRW Phospholipase, patatin family BBEV_1513 ENOG4105FCD Major Facilitator BBEV_1514 ENOG4108SJC Membrane BBEV_1515 ENOG4107URF beta-phospho-glucomutase BBEV_1517 ENOG4105C26 Dehydrogenase BBEV_1520 ENOG4105C9Q fumarate hydratase class II BBEV_1523 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BBEV_1524 ENOG4105E0X reductase BBEV_1525 ENOG4105DZ1 carboxypeptidase BBEV_1527 ENOG4105CHM Aminotransferase BBEV_1528 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BBEV_1529 ENOG4105C7S Dehydrogenase BBEV_1530 ENOG410890F Dynamin family BBEV_1533 ENOG4105KRN Transcriptional regulator, abrb family BBEV_1536 ENOG4105C5Q Transcriptional regulator BBEV_1537 ENOG4107R37 Glutamate dehydrogenase BBEV_1538 ENOG4108HGU Histidine kinase BBEV_1539 ENOG4105E5H Transposase BBEV_1547 ENOG4105G9B Transcriptional regulator BBEV_1549 ENOG4105C28 cystathionine BBEV_1550 ENOG4105D6E homoserine dehydrogenase BBEV_1552 ENOG4105C3U ABC transporter BBEV_1553 ENOG4108JQ7 (ABC) transporter BBEV_1554 ENOG4105DEF Extracellular solute-binding protein, family 5 BBEV_1555 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BBEV_1556 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BBEV_1559 ENOG4105C28 cystathionine BBEV_1560 ENOG4105BZU Histidine kinase BBEV_1561 ENOG4105DAN ATP-dependent protease BBEV_1562 ENOG4105C94 Transporter BBEV_1564 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BBEV_1565 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BBEV_1567 ENOG4105BZU Histidine kinase BBEV_1568 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BBEV_1574 ENOG4108IUX (ABC) transporter BBEV_1575 ENOG4105RHA ABC transporter, permease BBEV_1576 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BBEV_1580 ENOG4105CTQ phosphohexokinase BBEV_1581 ENOG4108UKZ OsmC family BBEV_1583 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A BBEV_1585 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BBEV_1591 ENOG4108PCN EamA-like transporter family BBEV_1592 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BBEV_1595 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BBEV_1596 ENOG4105F1A Pyruvate formate-lyase BBEV_1599 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BBEV_1600 ENOG4107VFR oxidoreductase BBEV_1606 ENOG4105C5H ABC transporter BBEV_1607 ENOG4108EKI Dehydrogenase BBEV_1610 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BBEV_1611 ENOG4108ZHJ Organic hydroperoxide resistance protein BBEV_1612 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BBEV_1614 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BBEV_1615 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BBEV_1616 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BBEV_1618 ENOG4105C8Y Acetylornithine aminotransferase BBEV_1620 ENOG4108K60 carbamoyl-phosphate synthetase ammonia chain BBEV_1621 ENOG4105DBV ornithine carbamoyltransferase BBEV_1622 ENOG4105CDH Citrulline--aspartate ligase BBEV_1623 ENOG4105CH7 arginosuccinase BBEV_1625 ENOG4105CM2 brancheD-chain amino acid aminotransferase BBEV_1632 ENOG4108KK1 membrane protein AbrB duplication BBEV_1633 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) BBEV_1634 ENOG4108JPW Aminotransferase BBEV_1636 ENOG4105CI3 gtp-binding protein typa BBEV_1637 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BBEV_1641 ENOG4105CAG UPF0210 protein BBEV_1642 ENOG4105VUC UPF0237 protein BBEV_1644 ENOG4105H93 Acyltransferase family BBEV_1648 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BBEV_1649 ENOG4108MDK Dehydrogenase BBEV_1651 ENOG4105C7B Threonine dehydratase BBEV_1652 ENOG4105QNR S1 RNA binding domain protein BBEV_1657 ENOG4108RR8 protoporphyrinogen oxidase BBEV_1658 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BBEV_1663 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BBEV_1664 ENOG4105K4P CoA-binding domain protein BBEV_1665 ENOG4107YZX Universal stress protein BBEV_1666 ENOG4105E90 ABC transporter BBEV_1667 ENOG4108IJ8 ABC transporter BBEV_1668 ENOG4105CTD carboxy-peptidase BBEV_1670 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BBEV_1671 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BBEV_1672 ENOG41081VK Ribonuclease BBEV_1673 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BBEV_1674 ENOG4106F55 Protein of unknown function (DUF1273) BBEV_1675 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BBEV_1677 ENOG4107X2U Inherit from COG: Exonuclease-like protein BBEV_1678 ENOG4108I5C dEAD DEAH box helicase BBEV_1685 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) BBEV_1686 ENOG4107R88 Chemotaxis protein (CheV) BBEV_1689 ENOG4105CZV ABC transporter BBEV_1690 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BBEV_1692 ENOG4105CJ1 ABC, transporter BBEV_1693 ENOG4105CG3 alpha amylase, catalytic region BBEV_1701 ENOG4105D8G Major Facilitator superfamily BBEV_1702 ENOG4105EPM Diguanylate phosphodiesterase BBEV_1703 ENOG4105DB7 PHP domain protein BBEV_1704 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BBEV_1705 ENOG4105MI2 BBEV_1707 ENOG4106F1P AAA ATPase, central domain protein BBEV_1709 ENOG4108I0Z Aconitate hydratase BBEV_1713 ENOG4105EM7 Selenocysteine-specific translation elongation factor BBEV_1715 ENOG4105EC8 Methyl-accepting chemotaxis BBEV_1716 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) BBEV_1717 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) BBEV_1719 ENOG41088CC tellurite resistance protein tehB BBEV_1722 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BBEV_1723 ENOG4105CPF Cell wall formation (By similarity) BBEV_1732 ENOG4105C59 p-type ATPase BBEV_1733 ENOG4105VPX protein, conserved in bacteria BBEV_1734 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) BBEV_1735 ENOG4105VXM UPF0154 protein BBEV_1736 ENOG4105CV1 Transketolase (EC 2.2.1.1) BBEV_1737 ENOG4105VPS UPF0291 protein BBEV_1738 ENOG4108SVB resolvase BBEV_1740 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BBEV_1742 ENOG4105C5F glutamine synthetase BBEV_1743 ENOG4105CXI aluminum resistance protein BBEV_1744 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BBEV_1745 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BBEV_1746 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BBEV_1747 ENOG4107YX5 Pfam:DUF548 BBEV_1748 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BBEV_1749 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BBEV_1751 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BBEV_1752 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BBEV_1753 ENOG4105CPQ Dehydrogenase BBEV_1754 ENOG4105DQU oxidoreductase, subunit beta BBEV_1755 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BBEV_1757 ENOG4105MCT stage V sporulation protein S BBEV_1758 ENOG4105D48 metallophosphoesterase BBEV_1759 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) BBEV_1760 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BBEV_1761 ENOG4105C1J atp-dependent rna helicase BBEV_1762 ENOG4105CEV competence damage-inducible protein BBEV_1763 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BBEV_1766 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BBEV_1769 ENOG4105FDP GntR family transcriptional regulator BBEV_1770 ENOG4105CNU cell division protein FtsK BBEV_1772 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BBEV_1774 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BBEV_1775 ENOG4105C1V Peptidase, M16 BBEV_1776 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BBEV_1777 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BBEV_1778 ENOG4105DTN riboflavin biosynthesis protein ribF BBEV_1779 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BBEV_1780 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BBEV_1781 ENOG4105W7A Protein of unknown function (DUF503) BBEV_1782 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BBEV_1784 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BBEV_1785 ENOG4105CHV Transcription elongation factor NusA BBEV_1786 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BBEV_1787 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BBEV_1788 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BBEV_1789 ENOG4105DZP Membrane-associated zinc metalloprotease BBEV_1790 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BBEV_1791 ENOG4105KNE Phosphatidate cytidylyltransferase BBEV_1792 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BBEV_1793 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BBEV_1794 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BBEV_1795 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BBEV_1796 ENOG4105CE9 30S ribosomal protein S2 BBEV_1800 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BBEV_1802 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BBEV_1804 ENOG4108V3W Chemotaxis protein, CheW BBEV_1805 ENOG4105CBS Chea signal transduction histidine kinase BBEV_1806 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BBEV_1808 ENOG4105FZW flagellar biosynthesis regulator FlhF BBEV_1809 ENOG4105D7B Flagellar biosynthesis protein flha BBEV_1810 ENOG4105D00 flagellar biosynthetic protein flhB BBEV_1811 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BBEV_1812 ENOG4105VS8 Flagellar biosynthetic protein fliq BBEV_1813 ENOG4105CN7 Flagellar biosynthetic protein FliP BBEV_1815 ENOG4107YTP response regulator receiver protein BBEV_1816 ENOG4105DD5 Flagellar motor switch protein BBEV_1817 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BBEV_1819 ENOG41068WV flagellar FlbD family protein BBEV_1820 ENOG4105BZE flagellar hook protein, FlgE BBEV_1822 ENOG410822I Flagellar hook capping protein BBEV_1828 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BBEV_1829 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BBEV_1830 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BBEV_1831 ENOG4108ZC9 flagellar basal-body rod protein flgc BBEV_1832 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BBEV_1833 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) BBEV_1834 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BBEV_1835 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BBEV_1836 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BBEV_1837 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BBEV_1838 ENOG4105C79 DNA protecting protein DprA BBEV_1839 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BBEV_1840 ENOG4105CMV Succinyl-CoA synthetase subunit beta BBEV_1841 ENOG4105VM1 flagellar BBEV_1843 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BBEV_1844 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BBEV_1846 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BBEV_1847 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BBEV_1848 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BBEV_1850 ENOG4105VB6 UPF0109 protein BBEV_1851 ENOG4105K5M 30s ribosomal protein S16 BBEV_1853 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BBEV_1854 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BBEV_1855 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BBEV_1857 ENOG4105Y38 Kinase-associated protein B BBEV_1858 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BBEV_1859 ENOG410854A Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BBEV_1860 ENOG4105CHR reductase BBEV_1861 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BBEV_1862 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BBEV_1863 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BBEV_1864 ENOG4105CB5 ATP-dependent DNA helicase recG BBEV_1865 ENOG4105EJQ L-serine dehydratase BBEV_1867 ENOG4105EPR degv family BBEV_1868 ENOG4105DP4 dak2 domain fusion protein ylov BBEV_1869 ENOG4108ZAA Alkaline-shock protein BBEV_1870 ENOG4105VB9 50S ribosomal protein l28 BBEV_1871 ENOG4105FJ0 thiamine BBEV_1872 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BBEV_1873 ENOG4105DJV ribulose-phosphate 3-epimerase BBEV_1874 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BBEV_1875 ENOG4105D9P serine threonine protein kinase BBEV_1876 ENOG4108ZF3 Phosphatase BBEV_1877 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BBEV_1878 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BBEV_1879 ENOG4105C25 Primosomal protein n' BBEV_1880 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BBEV_1882 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BBEV_1883 ENOG4105KC4 UPF0296 protein BBEV_1884 ENOG4105DSJ YicC domain protein BBEV_1885 ENOG4105F23 Fibronectin-binding protein BBEV_1886 ENOG4105BZ1 (ABC) transporter BBEV_1887 ENOG4105BZ1 (ABC) transporter BBEV_1890 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BBEV_1892 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BBEV_1893 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BBEV_1894 ENOG4105CD3 dihydroorotase BBEV_1895 ENOG4105CXT aspartate transcarbamylase BBEV_1897 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BBEV_1898 ENOG4105C34 Pseudouridine synthase BBEV_1899 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BBEV_1902 ENOG4105DBK s4 domain protein BBEV_1903 ENOG41067XK integral membrane protein BBEV_1904 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BBEV_1905 ENOG4105DFA alanine racemase domain protein BBEV_1906 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BBEV_1907 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BBEV_1908 ENOG4105K67 small basic protein BBEV_1910 ENOG4108R2U division initiation protein BBEV_1912 ENOG4105D4A Cell wall formation (By similarity) BBEV_1913 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BBEV_1914 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BBEV_1916 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BBEV_1917 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BBEV_1918 ENOG4105CJN penicillin-binding protein BBEV_1920 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BBEV_1921 ENOG4108V6E Cell division protein mraZ BBEV_1922 ENOG41074B2 UPF0747 protein BBEV_1925 ENOG4108YG3 N-acetyltransferase BBEV_1926 ENOG4105E39 Enoyl-CoA hydratase BBEV_1927 ENOG4105KNH Nucleic acid-binding protein BBEV_1928 ENOG4105CDE UPF0348 protein BBEV_1929 ENOG41063PX domain protein BBEV_1930 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BBEV_1931 ENOG4106H78 methyltransferase BBEV_1932 ENOG4105WUC UPF0298 protein BBEV_1935 ENOG4108REF Sporulation integral membrane protein ytvi BBEV_1937 ENOG41064X9 cytochrome C oxidase subunit IV BBEV_1938 ENOG4107QS1 Cytochrome C Oxidase, Subunit III BBEV_1939 ENOG4105BZ9 Cytochrome C oxidase, subunit I BBEV_1940 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) BBEV_1941 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BBEV_1942 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) BBEV_1943 ENOG4108RMU ferritin dps family protein BBEV_1944 ENOG4105ZPI UPF0358 protein BBEV_1948 ENOG4105QA2 BBEV_1950 ENOG4105DQ6 Transposase BBEV_1951 ENOG4105ECY inositol monophosphatase BBEV_1953 ENOG4108WQ8 UPF0637 protein BBEV_1954 ENOG4105WBI UPF0223 protein BBEV_1955 ENOG4105CXN decarboxylase BBEV_1961 ENOG4105C7S Dehydrogenase BBEV_1962 ENOG4105CPP Dehydrogenase, E1 component BBEV_1966 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BBEV_1967 ENOG4106148 UPF0356 protein BBEV_1968 ENOG4105CN5 Metallo-Beta-Lactamase BBEV_1969 ENOG4107ZYR domain protein BBEV_1970 ENOG4105D8X mechanosensitive ion channel BBEV_1971 ENOG4105CH2 amidohydrolase BBEV_1973 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BBEV_1975 ENOG4105D64 Mechanosensitive ion channel BBEV_1977 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BBEV_1978 ENOG4108DBC nitroreductase BBEV_1981 ENOG4108ZMI UPF0477 protein BBEV_1982 ENOG4108W5N phosphatidylglycerophosphatase a BBEV_1984 ENOG4105VG1 fes assembly suf system protein BBEV_1987 ENOG4107QMU Mate efflux family protein BBEV_1992 ENOG4105C94 Transporter BBEV_1994 ENOG4105C82 Malate synthase BBEV_1995 ENOG4105BZ8 glutamate synthase BBEV_1999 ENOG4105BZU Histidine kinase BBEV_2000 ENOG4105BZU Histidine kinase BBEV_2004 ENOG4105DR5 peptidase BBEV_2006 ENOG4105C0R drug resistance transporter emrb qaca subfamily BBEV_2009 ENOG4105EMS pseudouridine synthase BBEV_2012 ENOG4105E4C Lytic transglycosylase catalytic BBEV_2013 ENOG4108Z18 K06886 hemoglobin BBEV_2014 ENOG4105T58 Dithiol-disulfide isomerase BBEV_2015 ENOG4105DPN Oligoendopeptidase f BBEV_2022 ENOG4105FEU K -dependent Na -Ca exchanger BBEV_2023 ENOG4105C31 Tryptophanyl-tRNA synthetase BBEV_2024 ENOG4107V6Q Cyclic nucleotide-binding domain BBEV_2025 ENOG4108RCF TRANSCRIPTIONal BBEV_2026 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BBEV_2027 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BBEV_2029 ENOG4107V6Q Cyclic nucleotide-binding domain BBEV_2031 ENOG4105CVM Molybdenum cofactor synthesis domain protein BBEV_2032 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BBEV_2033 ENOG4108ZAF Molybdopterin BBEV_2035 ENOG4108KF3 Electron transport protein SCO1 SenC BBEV_2037 ENOG4108KP7 hydrolase BBEV_2040 ENOG4108UMN azlc family BBEV_2043 ENOG4105C0D helicase BBEV_2046 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BBEV_2047 ENOG4105C02 permease BBEV_2048 ENOG4105FKQ transcriptional regulator BBEV_2049 ENOG4105EG2 ABC transporter, permease BBEV_2053 ENOG4105FTV AraC Family Transcriptional Regulator BBEV_2062 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BBEV_2063 ENOG4105C02 permease BBEV_2064 ENOG4105FKQ transcriptional regulator BBEV_2066 ENOG4105EG2 ABC transporter, permease BBEV_2069 ENOG4105FTV AraC Family Transcriptional Regulator BBEV_2070 ENOG4105UQX Mate efflux family protein BBEV_2074 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BBEV_2075 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BBEV_2079 ENOG4105DYS nad(p)h dehydrogenase (quinone) BBEV_2080 ENOG4105BZU Histidine kinase BBEV_2081 ENOG4105KZX Pterin carbinolamine dehydratase BBEV_2083 ENOG4108UXE Protein tyrosine phosphatase BBEV_2084 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BBEV_2085 ENOG4107V6Q Cyclic nucleotide-binding domain BBEV_2086 ENOG41067SE Tetr family transcriptional regulator BBEV_2090 ENOG4105UIB (ABC) transporter BBEV_2091 ENOG4108JQ9 ABC transporter BBEV_2092 ENOG4105DIH basic membrane BBEV_2093 ENOG4105ENY Ethanolamine utilization protein eutH BBEV_2094 ENOG4105PW4 Sugar fermentation stimulation protein homolog BBEV_2098 ENOG4105BZ4 penicillin-binding protein BBEV_2104 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BBEV_2106 ENOG4105CDY transcriptional regulatory protein BBEV_2111 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BBEV_2112 ENOG4105TRT Transcriptional regulator BBEV_2118 ENOG4105EC8 Methyl-accepting chemotaxis BBEV_2119 ENOG4108NVR Methyl-accepting chemotaxis BBEV_2123 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BBEV_2127 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BBEV_2133 ENOG4108NEM leader-binding protein dmsD BBEV_2134 ENOG4105BZ8 glutamate synthase BBEV_2135 ENOG4105C3J Cysteine desulfurase BBEV_2137 ENOG4105BZU Histidine kinase BBEV_2139 ENOG4107RBI VanW family BBEV_2140 ENOG4105DP4 dak2 domain fusion protein ylov BBEV_2143 ENOG4108QTI )-transporter BBEV_2146 ENOG4107RCV ABC transporter, permease BBEV_2150 ENOG4106NZI LysR family Transcriptional regulator BBEV_2155 ENOG4105EEQ Na H antiporter BBEV_2156 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BBEV_2157 ENOG4105CHR reductase BBEV_2162 ENOG4108W2W BBEV_2163 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BBEV_2164 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) BBEV_2168 ENOG4105C3J Cysteine desulfurase BBEV_2170 ENOG4105EYH Exonuclease BBEV_2179 ENOG4105C0D helicase BBEV_2181 ENOG4105ER2 Ompa motb domain protein BBEV_2188 ENOG4105CNV Aldolase BBEV_2189 ENOG4108JUB Transcriptional regulator BBEV_2192 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BBEV_2193 ENOG4105CUT histidyl-tRNA synthetase BBEV_2194 ENOG4105E98 transcriptional regulator DeoR family BBEV_2195 ENOG4105DJV ribulose-phosphate 3-epimerase BBEV_2196 ENOG41080HJ 6-phospho 3-hexuloisomerase BBEV_2197 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BBEV_2198 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BBEV_2199 ENOG4105CTS PTS system mannitol-specific BBEV_2201 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BBEV_2202 ENOG41086B8 CoB-CoM heterodisulfide reductase BBEV_2203 ENOG4105E33 succinate dehydrogenase BBEV_2204 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) BBEV_2206 ENOG4107GFK fumarate BBEV_2207 ENOG4107QPK )-transporter BBEV_2208 ENOG4108MRH transcriptional regulatory protein BBEV_2211 ENOG4105QAX Iron-sulfur BBEV_2212 ENOG4107QY8 reductase BBEV_2213 ENOG4108NEM leader-binding protein dmsD BBEV_2214 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BBEV_2215 ENOG4108J2R molybdopterin oxidoreductase BBEV_2216 ENOG4105G9B Transcriptional regulator BBEV_2228 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BBEV_2229 ENOG4105DHF Membrane BBEV_2235 ENOG4105DA5 (ABC) transporter BBEV_2238 ENOG4105D3R alkyl hydroperoxide reductase BBEV_2241 ENOG4105D06 uba thif-type nad fad binding protein BBEV_2242 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BBEV_2243 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BBEV_2244 ENOG41080HI glycine oxidase BBEV_2245 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BBEV_2246 ENOG4105DMT epimerase dehydratase BBEV_2248 ENOG4105EYH Exonuclease BBEV_2249 ENOG4107RFY SbcCD D subunit BBEV_2250 ENOG4105EMU Dehydrogenase BBEV_2252 ENOG4107VHA regulatoR BBEV_2253 ENOG4108J2R molybdopterin oxidoreductase BBEV_2257 ENOG4105QAX Iron-sulfur BBEV_2258 ENOG4108J2R molybdopterin oxidoreductase BBEV_2284 ENOG4105TUA UPF0295 protein BBEV_2285 ENOG4105G5W regulator Fur family BBEV_2287 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase BBEV_2290 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BBEV_2291 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BBEV_2292 ENOG4105CBC glutamate synthase BBEV_2293 ENOG4107NBY Membrane BBEV_2295 ENOG4105BZ1 (ABC) transporter BBEV_2296 ENOG4105EVI UPF0374 protein BBEV_2299 ENOG4107QJZ Glycosyl transferase, family 2 BBEV_2301 ENOG4105EFI regulatoR BBEV_2302 ENOG4105FGV Chromate BBEV_2303 ENOG4105FGV Chromate BBEV_2304 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BBEV_2305 ENOG4105CHR reductase BBEV_2306 ENOG4105CEN a g-specific adenine glycosylase BBEV_2307 ENOG41067AE Membrane-bound metal-dependent hydrolase BBEV_2310 ENOG410902V Modulates RecA activity (By similarity) BBEV_2311 ENOG4105ECP epimerase BBEV_2313 ENOG4107414 GntR family transcriptional regulator BBEV_2315 ENOG410870W N-acetyltransferase BBEV_2318 ENOG4105C3M thioredoxin reductase BBEV_2325 ENOG41080XS Cobyrinic acid ac-diamide synthase BBEV_2326 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit BBEV_2328 ENOG4105C45 hydrogenase expression formation protein (HypE) BBEV_2329 ENOG4105CQS hydrogenase expression formation protein HypD BBEV_2330 ENOG41083WG hydrogenase assembly chaperone BBEV_2331 ENOG4105C8H hydrogenase maturation protein Hypf BBEV_2332 ENOG4107RSS Hydrogenase accessory protein HypB BBEV_2333 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) BBEV_2338 ENOG4105E3S small subunit BBEV_2339 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BBEV_2346 ENOG4108ISG Major Facilitator BBEV_2351 ENOG4105E9Q Acyl-transferase BBEV_2353 ENOG410855V Acylphosphatase BBEV_2355 ENOG4105CVP deoxyribo-dipyrimidine photolyase BBEV_2357 ENOG4105C26 Dehydrogenase BBEV_2359 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BBEV_2360 ENOG41077A9 carbonic anhydrase BBEV_2361 ENOG4105VFE sira family BBEV_2362 ENOG4105VFE sira family BBEV_2364 ENOG4108REF Sporulation integral membrane protein ytvi BBEV_2368 ENOG4105C5H ABC transporter BBEV_2370 ENOG4107XC4 flavin reductase domain protein, FMN-binding BBEV_2371 ENOG4105FBA Phospholipase Carboxylesterase BBEV_2372 ENOG4105C9U ATP-dependent DNA helicase RecQ BBEV_2373 ENOG4108Z7R Chaperone CsaA BBEV_2374 ENOG4105XTG Pfam:DUF156 BBEV_2375 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BBEV_2377 ENOG4108NVR Methyl-accepting chemotaxis BBEV_2378 ENOG4105BZU Histidine kinase BBEV_2379 ENOG4105CPN adenine deaminase BBEV_2380 ENOG4105BZ1 (ABC) transporter BBEV_2381 ENOG4105BZ1 (ABC) transporter BBEV_2382 ENOG4105BZW Glycerate kinase BBEV_2384 ENOG4105FR1 rard protein BBEV_2386 ENOG4105DQ6 Transposase BBEV_2387 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BBEV_2392 ENOG4105BZU Histidine kinase BBEV_2395 ENOG4105C71 hydrolase family 65, central catalytic BBEV_2396 ENOG4108PSK reductase BBEV_2397 ENOG4105DHS permease protein BBEV_2398 ENOG4105CM4 permease protein BBEV_2399 ENOG4108IPW abc transporter atp-binding protein BBEV_2401 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BBEV_2402 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BBEV_2403 ENOG4105CMG Carbohydrate kinase BBEV_2404 ENOG4105C93 Xylose Isomerase BBEV_2405 ENOG4105E2R ROK family BBEV_2406 ENOG4106HBX Transcriptional Regulator AraC Family BBEV_2407 ENOG4105C2F Histidine kinase BBEV_2408 ENOG4105EQD regulatoR BBEV_2409 ENOG4105XN3 extracellular solute-binding protein family 1 BBEV_2412 ENOG4105DSG hydrolase family 43 BBEV_2420 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BBEV_2421 ENOG41069ER domain protein BBEV_2424 ENOG4105DQU oxidoreductase, subunit beta BBEV_2425 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BBEV_2426 ENOG4105BZU Histidine kinase BBEV_2427 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BBEV_2428 ENOG4105C6X Major Facilitator BBEV_2431 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase BBEV_2432 ENOG4105EXC Acyl-transferase BBEV_2434 ENOG4105CUC YeeE YedE family protein BBEV_2437 ENOG4105KHC sulfurtransferase BBEV_2439 ENOG4105FKZ Methyl-accepting chemotaxis BBEV_2441 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase BBEV_2446 ENOG4105DEN Luciferase family BBEV_2448 ENOG4105BZU Histidine kinase BBEV_2449 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BBEV_2451 ENOG4105DKQ ROK family BBEV_2453 ENOG4105EEM helicase BBEV_2454 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) BBEV_2458 ENOG4105E5H Transposase BBEV_2464 ENOG4108URH decarboxylase BBEV_2469 ENOG4107R37 Glutamate dehydrogenase BBEV_2474 ENOG4105BZU Histidine kinase BBEV_2475 ENOG4105CSU acyl-Coa dehydrogenase BBEV_2480 ENOG4105U5Y Transcriptional regulator BBEV_2481 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BBEV_2482 ENOG4105EHG Permease protein BBEV_2483 ENOG4105E0A ABC, transporter BBEV_2484 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BBEV_2486 ENOG4108UGV hypoxanthine phosphoribosyltransferase BBEV_2487 ENOG4105CVJ phosphoglycerate mutase BBEV_2490 ENOG4105C59 p-type ATPase BBEV_2492 ENOG4105BZU Histidine kinase BBEV_2495 ENOG4107V0Z fmn reductase BBEV_2497 ENOG4105KVH Transcriptional regulator BBEV_2499 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BBEV_2502 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BBEV_2503 ENOG4108Z18 K06886 hemoglobin BBEV_2504 ENOG4105EA8 2-Nitropropane dioxygenase BBEV_2506 ENOG4105CPC Aldo Keto reductase BBEV_2507 ENOG4108K4B hydrolase BBEV_2509 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BBEV_2511 ENOG4105DY9 regulatoR BBEV_2512 ENOG4108HRK Histidine kinase BBEV_2541 ENOG4107R3N Filamentation induced by cAMP protein fic BBEV_2546 ENOG4105E5H Transposase BBEV_2557 ENOG4105E5H Transposase BBEV_2558 ENOG4105EQR Transposase IS116 IS110 IS902 BBEV_2565 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BBEV_2569 ENOG4107R5R arsenical pump membrane protein BBEV_2573 ENOG41082YX Transcriptional regulator, arsr family BBEV_2575 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BBEV_2578 ENOG4105CBD Diacylglycerol kinase BBEV_2580 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BBEV_2581 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BBEV_2582 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BBEV_2584 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BBEV_2585 ENOG4105C4R Atp-dependent dna helicase BBEV_2586 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) BBEV_2587 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BBEV_2588 ENOG4105M6F mutator MutT protein BBEV_2589 ENOG4108F3G Type I restriction-modification system, R subunit BBEV_2592 ENOG4105JZI cytochrome P450 BBEV_2594 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BBEV_2596 ENOG4105CKI cobalamin synthesis protein BBEV_2599 ENOG4105FBA Phospholipase Carboxylesterase BBEV_2600 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BBEV_2602 ENOG4105KGF protein, YerC YecD BBEV_2603 ENOG4108R5T secreted protein BBEV_2607 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BBEV_2608 ENOG4105C3M thioredoxin reductase BBEV_2609 ENOG4105ETU transcriptional activator (TenA BBEV_2611 ENOG4105D5T phosphonate abc transporter BBEV_2619 ENOG4108UW5 maltose o-acetyltransferase BBEV_2620 ENOG4105C12 Phosphoribosylglycinamide synthetase BBEV_2621 ENOG4105DC1 bifunctional purine biosynthesis protein purh BBEV_2622 ENOG4108V3E phosphoribosylglycinamide formyltransferase BBEV_2625 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BBEV_2627 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BBEV_2628 ENOG4105C8V SAICAR synthetase BBEV_2629 ENOG4105C83 adenylosuccinate lyase BBEV_2630 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BBEV_2631 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BBEV_2636 ENOG4105BZU Histidine kinase BBEV_2639 ENOG4105CE1 Ferrous iron transport protein b BBEV_2641 ENOG4105C7N Xanthine uracil vitamin C permease BBEV_2642 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BBEV_2645 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BBEV_2646 ENOG4105BZU Histidine kinase BBEV_2649 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BBEV_2650 ENOG4108JJ8 (ABC) transporter BBEV_2651 ENOG4108JJ9 ABC, transporter BBEV_2652 ENOG4105BZU Histidine kinase BBEV_2658 ENOG4105F8J Adenylate Guanylate cyclase BBEV_2660 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BBEV_2661 ENOG4105BZU Histidine kinase BBEV_2666 ENOG4107TPS domain protein BBEV_2667 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BBEV_2670 ENOG4105C0A alcohol dehydrogenase BBEV_2671 ENOG4105D8V Glucose sorbosone dehydrogenase BBEV_2674 ENOG4108IYU L-aspartate oxidase BBEV_2675 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BBEV_2676 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BBEV_2677 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BBEV_2678 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BBEV_2684 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BBEV_2686 ENOG4105C5R Aminotransferase BBEV_2690 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) BBEV_2691 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BBEV_2692 ENOG41080AZ Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BBEV_2693 ENOG4105XRQ Xanthine dehydrogenase accessory factor BBEV_2694 ENOG4107YV9 domain protein BBEV_2695 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding BBEV_2698 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BBEV_2701 ENOG4105DZC cytosine deaminase BBEV_2702 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BBEV_2705 ENOG4105DZC cytosine deaminase BBEV_2706 ENOG4105G9B Transcriptional regulator BBEV_2708 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BBEV_2712 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BBEV_2715 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BBEV_2716 ENOG4105VDT -acetyltransferase BBEV_2717 ENOG4107S17 Phosphate-binding protein BBEV_2720 ENOG4105E33 succinate dehydrogenase BBEV_2722 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BBEV_2723 ENOG4108IJ0 Aspartate ammonia-lyase BBEV_2725 ENOG4105HDK L-asparaginase BBEV_2731 ENOG4108NEV two component transcriptional regulator, LytTR family BBEV_2733 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BBEV_2734 ENOG4107RUY (E1 component), alpha subunit BBEV_2736 ENOG4107QKR Dehydrogenase BBEV_2740 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BBEV_2744 ENOG4107RU9 Transcriptional regulator, Crp Fnr family BBEV_2747 ENOG4105SZ6 Thioredoxin BBEV_2748 ENOG4108RMU ferritin dps family protein BBEV_2749 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BBEV_2754 ENOG4105C8P )-transporter BBEV_2761 ENOG4105CGD Nad-dependent epimerase dehydratase BBEV_2763 ENOG4105CPC Aldo Keto reductase BBEV_2764 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BBEV_2765 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BBEV_2768 ENOG4107QY8 reductase BBEV_2770 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BBEV_2772 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BBEV_2775 ENOG4105C0R drug resistance transporter emrb qaca subfamily BBEV_2776 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BBEV_2778 ENOG4105C5H ABC transporter BBEV_2779 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BBEV_2780 ENOG410801F ribosomal-protein-alanine acetyltransferase BBEV_2781 ENOG41072GX Peptidase M22 Glycoprotease BBEV_2782 ENOG4105K8N protein family UPF0079, ATPase BBEV_2783 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BBEV_2784 ENOG4105C28 cystathionine BBEV_2785 ENOG4108JJ8 (ABC) transporter BBEV_2786 ENOG4108JJ9 ABC, transporter BBEV_2787 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BBEV_2788 ENOG4105C4M (Ubiquinol oxidase) subunit I BBEV_2801 ENOG410906U SprT-like BBEV_2805 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BBEV_2806 ENOG4105WN5 stage II sporulation protein BBEV_2807 ENOG4107SGM protein serine threonine phosphatase BBEV_2808 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BBEV_2809 ENOG4105FUA antagonist BBEV_2810 ENOG4107MMM Anti-sigma-factor antagonist BBEV_2811 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BBEV_2813 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BBEV_2814 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BBEV_2815 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BBEV_2817 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component BBEV_2819 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BBEV_2822 ENOG4105C8Y Acetylornithine aminotransferase BBEV_2823 ENOG4105C26 Dehydrogenase BBEV_2824 ENOG4108JUB Transcriptional regulator BBEV_2830 ENOG4105BZU Histidine kinase BBEV_2834 ENOG4105C94 Transporter BBEV_2836 ENOG4105WMR Protein CrcB homolog BBEV_2837 ENOG4105C5Y PTS System BBEV_2838 ENOG4105ETE Transcriptional regulator (LacI family BBEV_2839 ENOG4105VEQ Cold shock protein BBEV_2841 ENOG4105CHH sulfate transporter BBEV_2842 ENOG4107YZX Universal stress protein BBEV_2843 ENOG4108D32 Methyltransferase BBEV_2844 ENOG4105C3S Mate efflux family protein BBEV_2846 ENOG4105BZU Histidine kinase BBEV_2847 ENOG41082YX Transcriptional regulator, arsr family BBEV_2848 ENOG4105CJW magnesium transporter BBEV_2851 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein BBEV_2852 ENOG4105E5Q amino acid AbC transporter BBEV_2855 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BBEV_2859 ENOG4105C28 cystathionine BBEV_2860 ENOG4105C28 cystathionine BBEV_2864 ENOG4105WCN acetyltransferase BBEV_2865 ENOG4105C0R drug resistance transporter emrb qaca subfamily BBEV_2866 ENOG4105E63 Pfam:DUF178 BBEV_2867 ENOG4108UIH futalosine nucleosidase BBEV_2873 ENOG4105CZV ABC transporter BBEV_2874 ENOG4107RJJ Transcriptional regulator BBEV_2880 ENOG4105EN6 Membrane BBEV_2883 ENOG4108UT2 hemolysin iii BBEV_2884 ENOG4105C87 Aminotransferase class I and II BBEV_2886 ENOG4105BZU Histidine kinase BBEV_2887 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BBEV_2888 ENOG4105C94 Transporter BBEV_2890 ENOG4107TPS domain protein BBEV_2894 ENOG4107QM2 Aldo Keto reductase BBEV_2895 ENOG4105D0M Protease HtpX homolog BBEV_2898 ENOG4105CS1 NAD(P)H quinone oxidoreductase BBEV_2900 ENOG41090MY MarR family Transcriptional regulator BBEV_2902 ENOG41080BT SNARE associated Golgi BBEV_2905 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase BBEV_2906 ENOG4105CMR udp-glucose 4-epimerase BBEV_2907 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BBEV_2909 ENOG4105CQ4 Transcriptional regulator BBEV_2915 ENOG4108V0P LemA family BBEV_2916 ENOG4105D0M Protease HtpX homolog BBEV_2917 ENOG4105K56 Transcriptional regulator BBEV_2919 ENOG4105C8Q Methyl-accepting chemotaxis BBEV_2922 ENOG4105E4C Lytic transglycosylase catalytic BBEV_2923 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BBEV_2925 ENOG4105C4C beta-galactosidase BBEV_2929 ENOG4108AEY RNA polymerase sigma factor BBEV_2933 ENOG4108RAV Conserved protein BBEV_2934 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BBEV_2939 ENOG4105KG3 cytidine deaminase BBEV_2945 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) BBEV_2948 ENOG4105ETD TRANSCRIPTIONal BBEV_2950 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BBEV_2956 ENOG4107S1E Beta-lactamase BBEV_2957 ENOG4105CYC Transferase BBEV_2958 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BBEV_2959 ENOG4105CK7 Sodium proline symporter BBEV_2962 ENOG4105CHR reductase BBEV_2964 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BBEV_2965 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BBEV_2966 ENOG4107U5W ybbr family BBEV_2967 ENOG4105C8B TIGR00159 family BBEV_2969 ENOG4105EMN RNA polymerase sigma factor BBEV_2976 ENOG4105D1F ATP-binding protein BBEV_2977 ENOG4107RRM 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BBEV_2979 ENOG4105CPC Aldo Keto reductase BBEV_2982 ENOG4108ZJ4 polysaccharide deacetylase BBEV_2983 ENOG4105BZ1 (ABC) transporter BBEV_2984 ENOG4105BZ1 (ABC) transporter BBEV_2988 ENOG4107HG4 Transcriptional regulator BBEV_2989 ENOG4108IJ7 Glycine betaine BBEV_2992 ENOG4105D5T phosphonate abc transporter BBEV_2996 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BBEV_2998 ENOG4108MDK Dehydrogenase BBEV_2999 ENOG4105CMD Transcriptional regulator, GntR family BBEV_3001 ENOG4105EF1 ribulokinase BBEV_3003 ENOG4108JE9 extracellular solute-binding protein family 1 BBEV_3005 ENOG4105DRS transport system, permease BBEV_3007 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BBEV_3009 ENOG4105E0C molybdate abc transporter BBEV_3010 ENOG4108IJ6 ABC transporter BBEV_3014 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BBEV_3016 ENOG4108JE9 extracellular solute-binding protein family 1 BBEV_3018 ENOG4105ETE Transcriptional regulator (LacI family BBEV_3020 ENOG41066F8 ROK family BBEV_3024 ENOG4105BZU Histidine kinase BBEV_3028 ENOG4106G6Q Transcriptional regulator BBEV_3029 ENOG4108JE9 extracellular solute-binding protein family 1 BBEV_3030 ENOG4105F8D glycoside hydrolase family 4 BBEV_3031 ENOG4105HHM rdd domain containing protein BBEV_3039 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BBEV_3040 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BBEV_3042 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BBEV_3045 ENOG4105DRS transport system, permease BBEV_3047 ENOG4108IJG ABC transporter substrate-binding protein BBEV_3049 ENOG4105ETE Transcriptional regulator (LacI family BBEV_3050 ENOG4105NAE bifunctional deaminase-reductase domain protein BBEV_3051 ENOG4106HB6 Alpha beta hydrolase BBEV_3056 ENOG4105ENE Histidine kinase BBEV_3057 ENOG4105WH1 Two component transcriptional regulator luxr family BBEV_3060 ENOG4107RZC phospholipase d BBEV_3061 ENOG4108V06 Glutathione peroxidase BBEV_3068 ENOG4105D9R oxidoreductase BBEV_3069 ENOG4107QP6 Xylose isomerase domain protein TIM barrel BBEV_3074 ENOG4105I7V membrAne BBEV_3075 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BBEV_3076 ENOG4105MKU Transcriptional regulator BBEV_3077 ENOG4105BZU Histidine kinase BBEV_3082 ENOG41089UC methyltransferase, type 11 BBEV_3083 ENOG410904A RNA polymerase BBEV_3086 ENOG4105CJ1 ABC, transporter BBEV_3093 ENOG4108J2P Alpha beta hydrolase fold BBEV_3097 ENOG4108X79 transcriptional regulator BBEV_3099 ENOG4105F8D glycoside hydrolase family 4 BBEV_3100 ENOG4105CK1 PTS System BBEV_3101 ENOG4105VCP PTS System BBEV_3102 ENOG4105VZJ PTS System BBEV_3103 ENOG4105E5H Transposase BBEV_3107 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BBEV_3109 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BBEV_3110 ENOG4107R39 (ABC) transporter BBEV_3126 ENOG4107R3N Filamentation induced by cAMP protein fic BBEV_3130 ENOG41086VY Fic/DOC family BBEV_3135 ENOG4107Y70 Heat shock protein BBEV_3148 ENOG4105BZU Histidine kinase BBEV_3154 ENOG4105DZR Type I site-specific deoxyribonuclease BBEV_3156 ENOG4105CVR type I restriction-modification system BBEV_3161 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BBEV_3166 ENOG4105VRR gCN5-related N-acetyltransferase BBEV_3170 ENOG4105EMD TRANSCRIPTIONal BBEV_3171 ENOG4106ETB IIa component BBEV_3173 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC BBEV_3174 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BBEV_3177 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BBEV_3178 ENOG4105EHZ conserved protein UCP016719 BBEV_3179 ENOG4105F8D glycoside hydrolase family 4 BBEV_3180 ENOG4105RD7 BadF BadG BcrA BcrD BBEV_3181 ENOG4105DRS transport system, permease BBEV_3182 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BBEV_3185 ENOG4107S1E Beta-lactamase BBEV_3188 ENOG4105CE4 GlcNAc 6-P deacetylase BBEV_3189 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BBEV_3190 ENOG4105FDP GntR family transcriptional regulator BBEV_3191 ENOG4108SU4 UPF0309 protein BBEV_3194 ENOG4105CJW magnesium transporter BBEV_3197 ENOG4105C26 Dehydrogenase BBEV_3198 ENOG4105TRT Transcriptional regulator BBEV_3200 ENOG4108JUB Transcriptional regulator BBEV_3203 ENOG4105C0A alcohol dehydrogenase BBEV_3204 ENOG4105C26 Dehydrogenase BBEV_3206 ENOG4105C09 Bile acid BBEV_3207 ENOG4105CVP deoxyribo-dipyrimidine photolyase BBEV_3208 ENOG4108VXD carboxy-peptidase BBEV_3209 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BBEV_3210 ENOG4105CAQ asparagine synthetase BBEV_3211 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BBEV_3212 ENOG4108UJD 30S ribosomal protein S9 BBEV_3213 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BBEV_3214 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BBEV_3215 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BBEV_3216 ENOG4108JJB ABC transporter BBEV_3217 ENOG4108JJB ABC transporter BBEV_3218 ENOG4108ZT0 50S ribosomal protein l17 BBEV_3219 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BBEV_3220 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BBEV_3221 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BBEV_3222 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BBEV_3224 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BBEV_3225 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BBEV_3226 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BBEV_3227 ENOG4105VPB 50S ribosomal protein L30 BBEV_3228 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BBEV_3229 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BBEV_3230 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BBEV_3231 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BBEV_3232 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BBEV_3233 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BBEV_3234 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BBEV_3235 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BBEV_3236 ENOG41082SA 50s ribosomal protein l29 BBEV_3237 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BBEV_3238 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BBEV_3239 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BBEV_3240 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BBEV_3241 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BBEV_3242 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BBEV_3243 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BBEV_3244 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BBEV_3245 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BBEV_3248 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BBEV_3249 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BBEV_3250 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BBEV_3251 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BBEV_3252 ENOG4105XPM ribosomal protein BBEV_3253 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BBEV_3254 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BBEV_3256 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BBEV_3258 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BBEV_3259 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BBEV_3260 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BBEV_3261 ENOG410683Z Preprotein translocase SecE subunit BBEV_3262 ENOG4105WDJ 50S ribosomal protein L33 BBEV_3265 ENOG4105QIV RNA polymerase BBEV_3266 ENOG4105M0M Tetracycline resistance protein BBEV_3267 ENOG4105C2N RNA methyltransferase TrmH family group 3 BBEV_3269 ENOG4105C8N cysteinyl-tRNA synthetase BBEV_3270 ENOG4105D7W serine acetyltransferase BBEV_3271 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BBEV_3272 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BBEV_3273 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BBEV_3274 ENOG4105CTP PilT protein domain protein BBEV_3275 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BBEV_3276 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BBEV_3277 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BBEV_3278 ENOG41066A3 ATP guanido phosphotransferase BBEV_3279 ENOG4108Z0C Uvrb UvrC protein BBEV_3281 ENOG4105KT7 mgtC SapB transporter BBEV_3283 ENOG4105NQC Flavodoxin BBEV_3301 ENOG4105CRK lysyL-tRNA synthetase BBEV_3302 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BBEV_3303 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BBEV_3304 ENOG4105KRF dihydroneopterin aldolase BBEV_3305 ENOG4105EEI dihydropteroate synthase BBEV_3306 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BBEV_3307 ENOG4105DDQ anthranilate synthase BBEV_3308 ENOG4105CRQ synthase (Component I) BBEV_3310 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BBEV_3311 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BBEV_3312 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BBEV_3313 ENOG4108UGV hypoxanthine phosphoribosyltransferase BBEV_3314 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BBEV_3317 ENOG41060GV RNA binding s1 domain protein BBEV_3319 ENOG41082I2 s4 domain protein BBEV_3320 ENOG4108IY2 MazG family BBEV_3322 ENOG4108JA2 transcriptioN-repair coupling factor BBEV_3323 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BBEV_3324 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BBEV_3325 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BBEV_3326 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BBEV_3327 ENOG4105K4W Could be involved in septation (By similarity) BBEV_3328 ENOG4105DFT pur operon repressor BBEV_3329 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BBEV_3330 ENOG4105W42 Veg protein BBEV_3331 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BBEV_3332 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BBEV_3333 ENOG41069ER domain protein BBEV_3334 ENOG4105F8V Hydrolase, tatD family BBEV_3335 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BBEV_3337 ENOG4105KRN Transcriptional regulator, abrb family BBEV_3338 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BBEV_3339 ENOG41060K3 Methyltransferase BBEV_3341 ENOG4105MA4 psp1 domain protein BBEV_3342 ENOG4105FA2 dna polymerase iii BBEV_3343 ENOG4105X0R protein from nitrogen regulatory protein P-II BBEV_3344 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BBEV_3345 ENOG4105CXN decarboxylase BBEV_3349 ENOG4107YRI Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BBEV_3355 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BBEV_3357 ENOG4105C6E dna polymerase iii BBEV_3360 ENOG4108Z6B deaminase BBEV_3361 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BBEV_3364 ENOG4108JQ7 (ABC) transporter BBEV_3365 ENOG4105C3U ABC transporter BBEV_3368 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BBEV_3369 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BBEV_3371 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BBEV_3377 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BBEV_3378 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BBEV_3379 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)