locus-tag class description CY96_00020 ENOG4105C8B TIGR00159 family CY96_00025 ENOG4107U5W ybbr family CY96_00040 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CY96_00065 ENOG4108PSK reductase CY96_00070 ENOG4108UMI ABC transporter, permease CY96_00075 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CY96_00080 ENOG4105D01 (LipO)protein CY96_00085 ENOG4105CB2 alcohol dehydrogenase CY96_00095 ENOG4105IQ5 FAD linked oxidase domain protein CY96_00110 ENOG4105C2C drug resistance transporter, Bcr CflA CY96_00125 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CY96_00130 ENOG4105C3U ABC transporter CY96_00135 ENOG4108JQ7 (ABC) transporter CY96_00165 ENOG4108J59 Extracellular solute-binding protein, family 5 CY96_00170 ENOG4108J59 Extracellular solute-binding protein, family 5 CY96_00190 ENOG4105E0C molybdate abc transporter CY96_00195 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CY96_00200 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CY96_00215 ENOG4105EGI Transcriptional regulator CY96_00235 ENOG4105F6E Acyl-transferase CY96_00260 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CY96_00285 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) CY96_00305 ENOG4105C5H ABC transporter CY96_00315 ENOG4105DEF Extracellular solute-binding protein, family 5 CY96_00325 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CY96_00330 ENOG4105C3U ABC transporter CY96_00335 ENOG4108JQ7 (ABC) transporter CY96_00340 ENOG410667J hydrolase CY96_00375 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase CY96_00380 ENOG4105ERH Fumarylacetoacetate hydrolase CY96_00390 ENOG4105CUB amino acid CY96_00395 ENOG4108SC4 )-transporter CY96_00400 ENOG4105CPF Cell wall formation (By similarity) CY96_00405 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CY96_00430 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CY96_00435 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CY96_00445 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CY96_00550 ENOG4105K8N protein family UPF0079, ATPase CY96_00555 ENOG41072GX Peptidase M22 Glycoprotease CY96_00560 ENOG410801F ribosomal-protein-alanine acetyltransferase CY96_00565 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CY96_00570 ENOG4105C5H ABC transporter CY96_00585 ENOG4108TYN CAAX amino terminal protease family protein CY96_00605 ENOG4105C7N Xanthine uracil vitamin C permease CY96_00615 ENOG4105BZU Histidine kinase CY96_00640 ENOG4107ZXU DSBA oxidoreductase CY96_00685 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CY96_00720 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CY96_00750 ENOG4105SX7 Transporter CY96_00780 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CY96_00785 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CY96_00790 ENOG4105C83 adenylosuccinate lyase CY96_00800 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CY96_00825 ENOG4108V3E phosphoribosylglycinamide formyltransferase CY96_00835 ENOG4105C12 Phosphoribosylglycinamide synthetase CY96_00860 ENOG4105C4R Atp-dependent dna helicase CY96_00865 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CY96_00885 ENOG4108W2Y isochorismatase CY96_00890 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CY96_00895 ENOG4108UMI ABC transporter, permease CY96_00900 ENOG4105D01 (LipO)protein CY96_00915 ENOG410834F Transcriptional regulator CY96_00920 ENOG4107I77 yiaA/B two helix domain CY96_00940 ENOG4105CBD Diacylglycerol kinase CY96_00945 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CY96_00950 ENOG4108JPW Aminotransferase CY96_00960 ENOG4105C26 Dehydrogenase CY96_00965 ENOG4105KPY Small multidrug resistance protein CY96_00995 ENOG4105D9N nucleoside CY96_01000 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CY96_01010 ENOG4108W15 Protein of unknown function (DUF1456) CY96_01025 ENOG4105DTQ mandelate racemase muconate lactonizing CY96_01035 ENOG4105DFD Na H antiporter CY96_01055 ENOG4105D3R alkyl hydroperoxide reductase CY96_01060 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CY96_01065 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CY96_01070 ENOG4107W7X Aldolase CY96_01075 ENOG4105EHG Permease protein CY96_01080 ENOG4105DQ5 transport system permease protein CY96_01085 ENOG4108V5C ABC transporter CY96_01090 ENOG4105CAY ferredoxin--nadp reductase CY96_01105 ENOG4106UIA CY96_01110 ENOG4106UIA CY96_01130 ENOG4105BZU Histidine kinase CY96_01150 ENOG410756H nucleotidyltransferase CY96_01155 ENOG4105D2S major facilitator superfamily CY96_01170 ENOG4105E5Q amino acid AbC transporter CY96_01175 ENOG4105EAB amino acid AbC transporter CY96_01185 ENOG4105C8Q Methyl-accepting chemotaxis CY96_01200 ENOG4105DBV ornithine carbamoyltransferase CY96_01210 ENOG4105C5B carbamate kinase CY96_01215 ENOG4108W63 CRP FNR family transcriptional regulator CY96_01225 ENOG4105DNP FAD linked oxidase domain protein CY96_01235 ENOG4105CI1 PTS System CY96_01250 ENOG4105C9U ATP-dependent DNA helicase RecQ CY96_01265 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CY96_01285 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CY96_01290 ENOG4105D2X ABC transporter substrate-binding protein CY96_01325 ENOG41062JF Transcriptional regulator CY96_01340 ENOG4105DEU major facilitator superfamily CY96_01355 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CY96_01370 ENOG4108N0M stress protein CY96_01375 ENOG4106FN3 tellurium resistance protein CY96_01380 ENOG4106FN3 tellurium resistance protein CY96_01385 ENOG4107TS3 membrane protein, TerC CY96_01390 ENOG4108TTB tellurium resistance protein CY96_01405 ENOG41068PA UPF0435 protein CY96_01410 ENOG4105KJF protein tyrosine phosphatase CY96_01420 ENOG4107U9T Pfam:Ribonuclease_BN CY96_01425 ENOG4105C59 p-type ATPase CY96_01430 ENOG4108IPJ Membrane CY96_01440 ENOG4105C3F Signal peptidase i CY96_01450 ENOG4107ZTW SNARE associated Golgi CY96_01465 ENOG410606W general stress protein CY96_01470 ENOG4105UPD Calcium Proton CY96_01505 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CY96_01510 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CY96_01520 ENOG4108JUB Transcriptional regulator CY96_01530 ENOG4108IQI permease CY96_01570 ENOG4108A04 Beta-lactamase CY96_01585 ENOG4105CKK Glycosyl transferase, family 2 CY96_01590 ENOG4107QQG Dehydrogenase CY96_01595 ENOG4105C3I Nad-dependent epimerase dehydratase CY96_01615 ENOG4105F1A Pyruvate formate-lyase CY96_01620 ENOG4108QBV Monogalactosyldiacylglycerol synthase CY96_01635 ENOG4105CI2 imidazolone-5-propionate hydrolase CY96_01640 ENOG4105ECP epimerase CY96_01670 ENOG41067AE Membrane-bound metal-dependent hydrolase CY96_01675 ENOG4105CEN a g-specific adenine glycosylase CY96_01680 ENOG4106BXE CY96_01700 ENOG4105BZ1 (ABC) transporter CY96_01705 ENOG4107NBY Membrane CY96_01710 ENOG4105CBC glutamate synthase CY96_01720 ENOG4108IUW ABC transporter CY96_01740 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CY96_01745 ENOG4105G5W regulator Fur family CY96_01850 ENOG4105CDY transcriptional regulatory protein CY96_01860 ENOG4108JQC penicillin-binding protein 1A CY96_01865 ENOG4108R9S DSBA oxidoreductase CY96_01875 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CY96_01885 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CY96_01900 ENOG4105CYN Serine protein kinase CY96_01920 ENOG4105C94 Transporter CY96_01935 ENOG4105DZ6 Band 7 protein CY96_01945 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CY96_01950 ENOG4108V9W transcriptional regulatory protein CY96_01955 ENOG4105D4T Citrate transporter CY96_01980 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CY96_01985 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CY96_01990 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CY96_01995 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CY96_02000 ENOG4105BZ7 extracellular solute-binding protein family 1 CY96_02010 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CY96_02015 ENOG4108STX response regulator CY96_02020 ENOG4105US7 Histidine kinase CY96_02045 ENOG4108MRH transcriptional regulatory protein CY96_02055 ENOG4105C6K Malic enzyme CY96_02070 ENOG4108UZ3 Transporter CY96_02075 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CY96_02085 ENOG4105BZU Histidine kinase CY96_02090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CY96_02105 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CY96_02110 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CY96_02115 ENOG4108JB9 formate dehydrogenase CY96_02135 ENOG4105CUB amino acid CY96_02150 ENOG4105C59 p-type ATPase CY96_02155 ENOG4105DAP Nicotinate phosphoribosyltransferase CY96_02190 ENOG41073R8 VanW family CY96_02195 ENOG4108KGH TRANSCRIPTIONal CY96_02200 ENOG4105D9N nucleoside CY96_02205 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CY96_02210 ENOG4105C37 (CBS) domain CY96_02215 ENOG4108IJ0 Aspartate ammonia-lyase CY96_02220 ENOG4105DAA L-lactate CY96_02235 ENOG4105DUX Transporter CY96_02240 ENOG4108MES Periplasmic binding protein CY96_02245 ENOG4105DQ5 transport system permease protein CY96_02250 ENOG4108IHU transport system permease protein CY96_02255 ENOG4105E0A ABC, transporter CY96_02260 ENOG4105DMQ Methyltransferase CY96_02265 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CY96_02270 ENOG4105EXW epimerase dehydratase CY96_02280 ENOG4107T89 von Willebrand factor, type A CY96_02285 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CY96_02290 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CY96_02300 ENOG4105BZU Histidine kinase CY96_02305 ENOG4105D5Q Arginine ornithine antiporter CY96_02310 ENOG4107414 GntR family transcriptional regulator CY96_02315 ENOG4105C5Y PTS System CY96_02320 ENOG4105CG3 alpha amylase, catalytic region CY96_02335 ENOG4105E1K spore germination protein CY96_02340 ENOG4105CRN Aminoglycoside phosphotransferase CY96_02345 ENOG4105BZG amino acid carrier protein CY96_02355 ENOG4105CDA abc transporter atp-binding protein CY96_02360 ENOG4105CT1 (ABC) transporter CY96_02365 ENOG4105EAD ABC transporter CY96_02370 ENOG4105DRP amino acid AbC transporter CY96_02375 ENOG4108IQI permease CY96_02390 ENOG4105D29 Helix-turn-helix type 11 domain protein CY96_02395 ENOG4105NAE bifunctional deaminase-reductase domain protein CY96_02400 ENOG4105BZU Histidine kinase CY96_02425 ENOG4105CHH sulfate transporter CY96_02430 ENOG41068KF Universal stress protein CY96_02440 ENOG4105CXY transporter CY96_02445 ENOG41067TZ transcriptional regulator, MarR family CY96_02450 ENOG4105C0R drug resistance transporter emrb qaca subfamily CY96_02455 ENOG4105ETE Transcriptional regulator (LacI family CY96_02460 ENOG4108RVA ribokinase CY96_02470 ENOG4105C2J ABC transporter CY96_02475 ENOG4105CNN ABC, transporter CY96_02480 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CY96_02485 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CY96_02520 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) CY96_02550 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CY96_02555 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CY96_02560 ENOG41069ER domain protein CY96_02565 ENOG4105VZ8 Transcriptional regulator CY96_02570 ENOG4107D63 CY96_02585 ENOG4105DUX Transporter CY96_02610 ENOG4105C85 amino acid CY96_02615 ENOG4105C7N Xanthine uracil vitamin C permease CY96_02630 ENOG4105MA6 gCN5-related N-acetyltransferase CY96_02650 ENOG4105CCU oxidase (Subunit III) CY96_02655 ENOG4105BZ9 Cytochrome C oxidase, subunit I CY96_02660 ENOG4105E2S oxidase) subunit II CY96_02685 ENOG4106CAD Protein of unknown function (DUF3311) CY96_02690 ENOG4105E1V na solute symporter CY96_02705 ENOG4108NHD germination protein CY96_02715 ENOG4105CE1 Ferrous iron transport protein b CY96_02720 ENOG4105CE1 Ferrous iron transport protein b CY96_02725 ENOG4105CE1 Ferrous iron transport protein b CY96_02730 ENOG4105CVA phosphate CY96_02735 ENOG4105C8U phosphate abc transporter CY96_02740 ENOG4105E2Z phosphate ABC transporter (Permease CY96_02780 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CY96_02860 ENOG41080XQ Signal transduction protein with cbs domains CY96_02880 ENOG4105ETU transcriptional activator (TenA CY96_02890 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CY96_02900 ENOG4108VEU Thiamine monophosphate synthase CY96_02905 ENOG41080HI glycine oxidase CY96_02920 ENOG4105D06 uba thif-type nad fad binding protein CY96_02925 ENOG4105DWF phosphomethylpyrimidine kinase CY96_02975 ENOG4108INS Transcriptional regulator CY96_02995 ENOG4105C7N Xanthine uracil vitamin C permease CY96_03005 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CY96_03025 ENOG4105C5Y PTS System CY96_03040 ENOG4105K63 Thioredoxin CY96_03060 ENOG4108B31 Spore germination protein CY96_03080 ENOG4107Y03 Nitroreductase CY96_03085 ENOG4105ED1 spovr family CY96_03095 ENOG4108TCS Glutamyl endopeptidase CY96_03100 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase CY96_03105 ENOG4105XTG Pfam:DUF156 CY96_03110 ENOG4105VFE sira family CY96_03115 ENOG4107TPS domain protein CY96_03120 ENOG4105VFE sira family CY96_03125 ENOG4105VFE sira family CY96_03135 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CY96_03140 ENOG41087NI Sulfite exporter TauE/SafE CY96_03150 ENOG4108KGH TRANSCRIPTIONal CY96_03175 ENOG4105EMD TRANSCRIPTIONal CY96_03180 ENOG4105VCP PTS System CY96_03185 ENOG4105VZJ PTS System CY96_03205 ENOG41069ER domain protein CY96_03210 ENOG4107RBB ABC transporter, permease CY96_03215 ENOG4105C19 ABC transporter CY96_03245 ENOG4105WEF catalase CY96_03280 ENOG4107T5V SNARE associated Golgi CY96_03315 ENOG4105CUB amino acid CY96_03320 ENOG4107RWR Sodium hydrogen exchanger CY96_03330 ENOG4106KNT transcriptional regulator CY96_03370 ENOG4108YXU transcriptional regulator AsnC family CY96_03375 ENOG4105CH7 arginosuccinase CY96_03380 ENOG4108IXY short-chain dehydrogenase reductase CY96_03390 ENOG4105KPY Small multidrug resistance protein CY96_03435 ENOG4105C19 ABC transporter CY96_03440 ENOG4107RBB ABC transporter, permease CY96_03445 ENOG4105C19 ABC transporter CY96_03480 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CY96_03485 ENOG4105E5W Transporter CY96_03500 ENOG4107RKG DJ-1/PfpI family CY96_03505 ENOG4105CH6 catalase CY96_03515 ENOG4105D5Q Arginine ornithine antiporter CY96_03520 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CY96_03530 ENOG4105C26 Dehydrogenase CY96_03540 ENOG4105BZ1 (ABC) transporter CY96_03545 ENOG4105BZ1 (ABC) transporter CY96_03555 ENOG4105DRP amino acid AbC transporter CY96_03560 ENOG4105CDA abc transporter atp-binding protein CY96_03575 ENOG410839P CY96_03610 ENOG4107FQX Alpha-acetolactate decarboxylase CY96_03615 ENOG4108VX5 3-methyladenine DNA glycosylase CY96_03630 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CY96_03635 ENOG4105D4P Coproporphyrinogen iii oxidase CY96_03660 ENOG4105CHH sulfate transporter CY96_03685 ENOG4105CGU Enoyl-CoA hydratase CY96_03705 ENOG4105DER m42 family CY96_03730 ENOG4105CIF Ornithine Cyclodeaminase CY96_03750 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CY96_03760 ENOG4108JQ7 (ABC) transporter CY96_03815 ENOG4108IBT Inherit from COG: transposase CY96_03845 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) CY96_03870 ENOG4105CSH Transporter CY96_03880 ENOG4108MRH transcriptional regulatory protein CY96_03930 ENOG4105CDU Replicative dna helicase CY96_03980 ENOG4105C0R drug resistance transporter emrb qaca subfamily CY96_04005 ENOG4105D9U N-acetyltransferase CY96_04095 ENOG4105F6J Alpha beta hydrolase fold CY96_04160 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CY96_04180 ENOG4105CMT Dihydroxyacetone kinase CY96_04190 ENOG4105CMT Dihydroxyacetone kinase CY96_04280 ENOG4105WN5 stage II sporulation protein CY96_04290 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CY96_04300 ENOG4108MJI response regulator CY96_04305 ENOG4105BZU Histidine kinase CY96_04310 ENOG4105BZU Histidine kinase CY96_04355 ENOG4107QHE Choloylglycine hydrolase CY96_04380 ENOG4107VRP DNA repair exonuclease CY96_04385 ENOG4106D4I domain protein CY96_04395 ENOG4105ED2 Beta-lactamase CY96_04430 ENOG4108MUZ hydrolase CY96_04450 ENOG4105F0F Oxalate decarboxylase CY96_04455 ENOG41067QW Transcriptional regulator CY96_04460 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CY96_04475 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CY96_04500 ENOG4105EEM helicase CY96_04505 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CY96_04530 ENOG4105K59 histidine triad (HIT) protein CY96_04565 ENOG410905X membrane-flanked domain protein CY96_04570 ENOG4105CKV Membrane CY96_04615 ENOG410905X membrane-flanked domain protein CY96_04620 ENOG4105CKV Membrane CY96_04625 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CY96_04630 ENOG4105BZ4 penicillin-binding protein CY96_04640 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CY96_04645 ENOG4105C1Q protoporphyrinogen oxidase CY96_04670 ENOG4105NA0 Transcriptional regulator CY96_04685 ENOG4105ECB domain protein CY96_04720 ENOG4108RQ5 Beta-lactamase domain-containing protein CY96_04725 ENOG4105DF9 Lipoate-protein, ligase CY96_04735 ENOG4105CEY Amp-dependent synthetase and ligase CY96_04745 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CY96_04750 ENOG4108I5D sulfate abc transporter CY96_04755 ENOG4105ECW sulfate abc transporter CY96_04760 ENOG4108IJ6 ABC transporter CY96_04765 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) CY96_04770 ENOG4107RN3 metallophosphoesterase CY96_04775 ENOG4107TVP HD domain protein CY96_04785 ENOG4108AEY RNA polymerase sigma factor CY96_04790 ENOG41086D8 Transcriptional regulator CY96_04805 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CY96_04825 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CY96_04830 ENOG4105C8Q Methyl-accepting chemotaxis CY96_04835 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) CY96_04850 ENOG4107QP3 malate synthase g CY96_04870 ENOG4105VEQ Cold shock protein CY96_04955 ENOG4105ERH Fumarylacetoacetate hydrolase CY96_04965 ENOG4105C8Y Acetylornithine aminotransferase CY96_04980 ENOG4105CAQ asparagine synthetase CY96_04985 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CY96_04990 ENOG4105CH6 catalase CY96_04995 ENOG4105BZU Histidine kinase CY96_05005 ENOG4108VPT UPF0234 protein CY96_05010 ENOG4105QNR S1 RNA binding domain protein CY96_05015 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CY96_05025 ENOG4107AYK membrAne CY96_05030 ENOG41073B9 CY96_05040 ENOG4108KP7 hydrolase CY96_05050 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CY96_05075 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CY96_05080 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CY96_05110 ENOG4105C31 Tryptophanyl-tRNA synthetase CY96_05125 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CY96_05130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CY96_05140 ENOG4108JQ7 (ABC) transporter CY96_05145 ENOG4105UQX Mate efflux family protein CY96_05165 ENOG4108ZCF integral membrane protein CY96_05175 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CY96_05185 ENOG4105DPN Oligoendopeptidase f CY96_05200 ENOG4108Z18 K06886 hemoglobin CY96_05205 ENOG4105MIX Adenylate cyclase CY96_05210 ENOG4106EFP UPF0738 protein CY96_05220 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CY96_05225 ENOG4105EMS pseudouridine synthase CY96_05245 ENOG4105K64 Glycosyl transferase, family 2 CY96_05265 ENOG4107TVC Glycosyl transferase, family 2 CY96_05285 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CY96_05290 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CY96_05300 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CY96_05350 ENOG4108ZMI UPF0477 protein CY96_05375 ENOG4105CK7 Sodium proline symporter CY96_05385 ENOG4105CRQ synthase (Component I) CY96_05390 ENOG4105DDQ anthranilate synthase CY96_05400 ENOG4105DK0 Indole-3-glycerol phosphate synthase CY96_05410 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CY96_05480 ENOG4105C7S Dehydrogenase CY96_05495 ENOG4105VZ8 Transcriptional regulator CY96_05525 ENOG4108IUX (ABC) transporter CY96_05530 ENOG4105RHA ABC transporter, permease CY96_05555 ENOG4105DZ1 carboxypeptidase CY96_05560 ENOG4105VFR signal peptidase CY96_05595 ENOG4105C26 Dehydrogenase CY96_05600 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CY96_05605 ENOG4105F38 ABC transporter, permease CY96_05610 ENOG4105D38 putrescine abc transporter CY96_05615 ENOG4107RUE extracellular solute-binding protein family 1 CY96_05625 ENOG4105EYF MMPL domain protein CY96_05635 ENOG4108YBP pseudouridine synthase CY96_05645 ENOG4105K4I Scp-like extracellular CY96_05650 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CY96_05655 ENOG4105CQB FAD linked oxidase domain protein CY96_05670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CY96_05675 ENOG4105BZU Histidine kinase CY96_05680 ENOG4105JXH GntR family transcriptional regulator CY96_05700 ENOG4106A3R peptidase CY96_05710 ENOG4108QTI )-transporter CY96_05715 ENOG4107TS3 membrane protein, TerC CY96_05720 ENOG4105CZN Potassium uptake protein CY96_05725 ENOG410681C small acid-soluble spore protein CY96_05730 ENOG4108Z7G MaoC domain protein dehydratase CY96_05750 ENOG4105CHR reductase CY96_05780 ENOG4105C4Y ABC transporter CY96_05785 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CY96_05790 ENOG4107RCV ABC transporter, permease CY96_05810 ENOG4105E98 transcriptional regulator DeoR family CY96_05825 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CY96_05835 ENOG4105PXI polysaccharide deacetylase CY96_05845 ENOG4105BZU Histidine kinase CY96_05850 ENOG41090MY MarR family Transcriptional regulator CY96_05860 ENOG4106DF1 CY96_05875 ENOG4105BZU Histidine kinase CY96_05880 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CY96_05885 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CY96_05890 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CY96_05930 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CY96_05935 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CY96_05940 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CY96_05945 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CY96_05950 ENOG4105CZV ABC transporter CY96_05960 ENOG4105CJ1 ABC, transporter CY96_06000 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CY96_06005 ENOG4105EA8 2-Nitropropane dioxygenase CY96_06010 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CY96_06020 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CY96_06045 ENOG4105NQC Flavodoxin CY96_06085 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CY96_06120 ENOG4105CZN Potassium uptake protein CY96_06125 ENOG41063Y9 CY96_06130 ENOG4105KBJ sporulation protein ytfj CY96_06150 ENOG4105CM2 brancheD-chain amino acid aminotransferase CY96_06155 ENOG4105C7K acetolactate synthase CY96_06160 ENOG4108ZP8 Acetolactate synthase small subunit CY96_06165 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CY96_06180 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CY96_06195 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CY96_06200 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CY96_06205 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CY96_06210 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CY96_06215 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CY96_06220 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CY96_06235 ENOG4107RVV histidinol phosphate phosphatase, hisj family CY96_06250 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CY96_06255 ENOG4105E0M Sulfatase CY96_06265 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CY96_06280 ENOG4107S4M Sulfate adenylate transferase CY96_06285 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CY96_06290 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CY96_06300 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CY96_06305 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CY96_06310 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CY96_06315 ENOG4105C8J )-transporter CY96_06340 ENOG4105DFD Na H antiporter CY96_06360 ENOG4105ENE Histidine kinase CY96_06365 ENOG4105WH1 Two component transcriptional regulator luxr family CY96_06385 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CY96_06410 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CY96_06430 ENOG4105CJ3 phosphate transporter CY96_06435 ENOG4107GRR phosphate transport regulator CY96_06440 ENOG4105BZ4 penicillin-binding protein CY96_06455 ENOG4105BZU Histidine kinase CY96_06460 ENOG4105I3N Conserved Protein CY96_06480 ENOG4105BZU Histidine kinase CY96_06510 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CY96_06515 ENOG4105DZ1 carboxypeptidase CY96_06520 ENOG4108JIC nucleoside recognition domain protein CY96_06530 ENOG4105FE9 pseudouridine synthase CY96_06535 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CY96_06540 ENOG4107TWT Cytochrome c biogenesis protein CY96_06545 ENOG4105CRE cytochrome C CY96_06550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CY96_06555 ENOG4105BZU Histidine kinase CY96_06560 ENOG4108WBT adenosyltransferase CY96_06575 ENOG4108SAX Membrane CY96_06590 ENOG4105C9U ATP-dependent DNA helicase RecQ CY96_06595 ENOG4105I7S Abortive infection protein CY96_06605 ENOG4107RGJ metallophosphoesterase CY96_06610 ENOG4108XDN Transcriptional regulator CY96_06615 ENOG4108S6Z Negative regulator of genetic competence CY96_06640 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CY96_06645 ENOG4107RB3 L-asparaginase CY96_06665 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) CY96_06680 ENOG4105S2F CY96_06685 ENOG41065D1 CY96_06715 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CY96_06730 ENOG4105XXQ heptaprenyl diphosphate synthase component I CY96_06740 ENOG4105EAH synthase CY96_06745 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CY96_06750 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CY96_06765 ENOG41068YB TPR repeat-containing protein CY96_06780 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CY96_06785 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CY96_06820 ENOG4108JYZ YitT family CY96_06825 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CY96_06840 ENOG4105FJR Lmbe family CY96_06845 ENOG4105CPK Glycosyl transferase (Group 1 CY96_06865 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CY96_06880 ENOG4105DVT helicase CY96_06905 ENOG4105CSM endonuclease III CY96_06915 ENOG4105BZ4 penicillin-binding protein CY96_06960 ENOG4106F55 Protein of unknown function (DUF1273) CY96_06970 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CY96_06980 ENOG4105DVT helicase CY96_06985 ENOG4105CTD carboxy-peptidase CY96_06995 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CY96_07000 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) CY96_07005 ENOG4105C2W permease CY96_07010 ENOG4105DHF Membrane CY96_07020 ENOG410890F Dynamin family CY96_07030 ENOG4108W0I acetyltransferase CY96_07040 ENOG4105KHC sulfurtransferase CY96_07085 ENOG4105HTX biosynthesis protein CY96_07115 ENOG4105CPK Glycosyl transferase (Group 1 CY96_07130 ENOG4108SZE gCN5-related N-acetyltransferase CY96_07150 ENOG41081VK Ribonuclease CY96_07215 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CY96_07225 ENOG4107RWR Sodium hydrogen exchanger CY96_07230 ENOG4105CN5 Metallo-Beta-Lactamase CY96_07235 ENOG4108Z5V transcriptional regulator, merr family CY96_07245 ENOG4105H67 Protein of unknown function (DUF421) CY96_07250 ENOG41080C8 DUF218 domain CY96_07285 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CY96_07295 ENOG4107R0U MotA TolQ exbB proton channel CY96_07300 ENOG4105ER2 Ompa motb domain protein CY96_07305 ENOG4107YTP response regulator receiver protein CY96_07310 ENOG4105CBS Chea signal transduction histidine kinase CY96_07315 ENOG4105DD5 Flagellar motor switch protein CY96_07330 ENOG4105BZU Histidine kinase CY96_07350 ENOG4105E1Q flagellar hook-associated protein CY96_07355 ENOG4105DTJ flagellar hook-associated protein CY96_07360 ENOG4105DTS flagellar hook-associated CY96_07375 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CY96_07380 ENOG4108ZC9 flagellar basal-body rod protein flgc CY96_07385 ENOG41075Z6 flagellar hook-basal body complex protein fliE CY96_07390 ENOG4107U2N Flagellar M-ring protein CY96_07395 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CY96_07425 ENOG4105BZE flagellar hook protein, FlgE CY96_07440 ENOG4107R88 Chemotaxis protein (CheV) CY96_07450 ENOG4105I03 Flagellin CY96_07455 ENOG4105I03 Flagellin CY96_07460 ENOG4105E4C Lytic transglycosylase catalytic CY96_07470 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CY96_07475 ENOG4105DD5 Flagellar motor switch protein CY96_07485 ENOG4105CN7 Flagellar biosynthetic protein FliP CY96_07490 ENOG4105VS8 Flagellar biosynthetic protein fliq CY96_07500 ENOG4105D00 flagellar biosynthetic protein flhB CY96_07505 ENOG4105D7B Flagellar biosynthesis protein flha CY96_07510 ENOG4105FZW flagellar biosynthesis regulator FlhF CY96_07515 ENOG4105KTQ flagellar basal-body rod protein CY96_07520 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CY96_07550 ENOG4105KAC Antibiotic biosynthesis monooxygenase CY96_07575 ENOG4105DUM transcriptional regulator, lysR family CY96_07590 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component CY96_07620 ENOG4105CVJ phosphoglycerate mutase CY96_07630 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CY96_07650 ENOG4105CAQ asparagine synthetase CY96_07670 ENOG4105PGM cation diffusion facilitator family transporter CY96_07680 ENOG4105DRR Transcriptional regulator, GntR family CY96_07685 ENOG4108UZ3 Transporter CY96_07695 ENOG4105CKI cobalamin synthesis protein CY96_07700 ENOG4108PJD permease CY96_07715 ENOG4105DFD Na H antiporter CY96_07720 ENOG4105VUF Transcriptional regulator CY96_07730 ENOG4105C9Q fumarate hydratase class II CY96_07750 ENOG4107QJQ Mate efflux family protein CY96_07755 ENOG4105EC3 peptidase S51, dipeptidase E CY96_07775 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CY96_07965 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CY96_08010 ENOG4105K63 Thioredoxin CY96_08035 ENOG4105C2M dna polymerase I CY96_08085 ENOG4105DQ6 Transposase CY96_08110 ENOG4106BRA Membrane CY96_08145 ENOG4105CJ1 ABC, transporter CY96_08170 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CY96_08180 ENOG4108IJ0 Aspartate ammonia-lyase CY96_08185 ENOG4105C6K Malic enzyme CY96_08245 ENOG4105FVX CY96_08250 ENOG4105E09 nadh pyrophosphatase CY96_08265 ENOG4105CSR polyphosphate kinase 2 CY96_08270 ENOG4105U3E Transcriptional regulator CY96_08280 ENOG4105DXI Major Facilitator superfamily CY96_08290 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CY96_08295 ENOG4105EU0 Major facilitator Superfamily CY96_08300 ENOG4105C6T cysteine synthase CY96_08320 ENOG4105C8J )-transporter CY96_08335 ENOG4105X5K response regulator receiver protein CY96_08340 ENOG4105H67 Protein of unknown function (DUF421) CY96_08370 ENOG4105CHR reductase CY96_08375 ENOG4105CM2 brancheD-chain amino acid aminotransferase CY96_08380 ENOG4105C7K acetolactate synthase CY96_08390 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CY96_08395 ENOG4105C01 Dihydroxy-acid dehydratase CY96_08400 ENOG4105C7B Threonine dehydratase CY96_08420 ENOG4105C6X Major Facilitator CY96_08425 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CY96_08435 ENOG4105DY9 regulatoR CY96_08440 ENOG4105CYC Transferase CY96_08445 ENOG4105K5X acetyltransferase CY96_08465 ENOG41068WN CY96_08470 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CY96_08485 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CY96_08500 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CY96_08510 ENOG4105C0X amino acid CY96_08535 ENOG4105K8R UPF0145 protein CY96_08550 ENOG4107RHR regulatoR CY96_08560 ENOG4105D9N nucleoside CY96_08565 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CY96_08605 ENOG4107RAQ aminopeptidase CY96_08615 ENOG4107R16 Multicopper oxidase CY96_08655 ENOG4108T5E Copper resistance protein CY96_08660 ENOG4105KTB nuclear export factor GLE1 CY96_08665 ENOG4107RT3 EamA-like transporter family CY96_08670 ENOG4105GZI Transcriptional regulator CY96_08675 ENOG4108Z40 Transcriptional regulator CY96_08680 ENOG4107ZXU DSBA oxidoreductase CY96_08685 ENOG4108TVJ Nitroreductase CY96_08695 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CY96_08700 ENOG4106F5Q Membrane CY96_08705 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CY96_08715 ENOG4105CKI cobalamin synthesis protein CY96_08725 ENOG4105C0Z ABC transporter CY96_08730 ENOG4108IV0 ABC, transporter CY96_08735 ENOG4105C32 Amino acid ABC transporter (Permease) CY96_08745 ENOG4105SKE transcriptional Regulator LysR family CY96_08780 ENOG4105C4M (Ubiquinol oxidase) subunit I CY96_08785 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CY96_08790 ENOG4108JJ9 ABC, transporter CY96_08795 ENOG4108JJ8 (ABC) transporter CY96_08805 ENOG4105K64 Glycosyl transferase, family 2 CY96_08815 ENOG4108UT6 Transferase hexapeptide repeat containing protein CY96_08875 ENOG4105BZ1 (ABC) transporter CY96_08880 ENOG4105EFI regulatoR CY96_08885 ENOG4105BZU Histidine kinase CY96_08895 ENOG41075D4 Aminoglycoside 6-adenylyltransferase CY96_08900 ENOG4108ZJ4 polysaccharide deacetylase CY96_08920 ENOG4105D6E homoserine dehydrogenase CY96_08930 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CY96_08945 ENOG4108KGH TRANSCRIPTIONal CY96_08955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CY96_08960 ENOG4105BZU Histidine kinase CY96_08965 ENOG4107VMI polysaccharide deacetylase CY96_08975 ENOG4105KT7 mgtC SapB transporter CY96_08980 ENOG4105VRR gCN5-related N-acetyltransferase CY96_08990 ENOG4105DUU IucA IucC family protein CY96_08995 ENOG4105CEY Amp-dependent synthetase and ligase CY96_09010 ENOG4108WBH protein TIM barrel CY96_09015 ENOG4105YWU small acid-soluble spore protein CY96_09025 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CY96_09030 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CY96_09080 ENOG4105KRN Transcriptional regulator, abrb family CY96_09120 ENOG4105C8Q Methyl-accepting chemotaxis CY96_09135 ENOG4108K88 Membrane CY96_09140 ENOG4108WPJ Ferritin-like domain CY96_09155 ENOG4105DEN Luciferase family CY96_09170 ENOG4105VMI -acetyltransferase CY96_09175 ENOG4107QM2 Aldo Keto reductase CY96_09180 ENOG4105CKI cobalamin synthesis protein CY96_09190 ENOG4105DSE periplasmic solute binding protein CY96_09200 ENOG4105K4T epimerase CY96_09210 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CY96_09255 ENOG4107T5V SNARE associated Golgi CY96_09270 ENOG4108PJD permease CY96_09280 ENOG4108S4H thioesterase Superfamily protein CY96_09290 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CY96_09310 ENOG4105SXS Protein of unknown function (DUF456) CY96_09315 ENOG4105C37 (CBS) domain CY96_09335 ENOG4108Z7R Chaperone CsaA CY96_09350 ENOG4108ZRV stage ii sporulation protein p CY96_09360 ENOG4108VXD carboxy-peptidase CY96_09370 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CY96_09390 ENOG4108ZRV stage ii sporulation protein p CY96_09400 ENOG4108X4Q Hydrolase CY96_09415 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CY96_09425 ENOG41087PP glycosyltransferase MGT family CY96_09430 ENOG4108JYZ YitT family CY96_09435 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CY96_09465 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CY96_09485 ENOG4106PAW secretion accessory protein EsaA YueB CY96_09495 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) CY96_09500 ENOG4108MGT Required for secretion of EsxA and EsxB CY96_09595 ENOG4105D7V transposase CY96_09605 ENOG4105KBJ sporulation protein ytfj CY96_09630 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CY96_09650 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CY96_09655 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CY96_09665 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CY96_09670 ENOG4105EMN RNA polymerase sigma factor CY96_09695 ENOG4108V06 Glutathione peroxidase CY96_09710 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CY96_09730 ENOG4108IUE nitrate reductase beta subunit CY96_09735 ENOG4105R3A Nitrate reductase CY96_09745 ENOG4107V6Q Cyclic nucleotide-binding domain CY96_09750 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CY96_09755 ENOG4105D06 uba thif-type nad fad binding protein CY96_09760 ENOG4105CVM Molybdenum cofactor synthesis domain protein CY96_09765 ENOG4108ZAF Molybdopterin CY96_09770 ENOG41067WU Molybdopterin converting factor (Subunit 1) CY96_09790 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CY96_09795 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CY96_09800 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CY96_09805 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CY96_09810 ENOG4108IFG nitrite reductase, (NAD(P)H) CY96_09815 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) CY96_09850 ENOG4105MCT stage V sporulation protein S CY96_09890 ENOG4105C5H ABC transporter CY96_09905 ENOG4108UUM single-stranded DNA-binding protein CY96_09935 ENOG4107YX5 Pfam:DUF548 CY96_09940 ENOG4105C75 arginyL-tRNA synthetase CY96_09960 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CY96_09975 ENOG4105C5S asparaginyl-tRNA synthetase CY96_09980 ENOG4105C8J )-transporter CY96_10000 ENOG4107XGZ Hydrolase CY96_10005 ENOG4105CY2 Citrate transporter CY96_10025 ENOG4105KD7 acetyltransferase CY96_10035 ENOG4105VMP Transcriptional regulator CY96_10040 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CY96_10065 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 CY96_10080 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) CY96_10085 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CY96_10095 ENOG4107RVG penicillin-binding protein CY96_10100 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CY96_10105 ENOG4105E9Q Acyl-transferase CY96_10110 ENOG4108UT2 hemolysin iii CY96_10120 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CY96_10130 ENOG4108RCR degv family CY96_10140 ENOG4108KF3 Electron transport protein SCO1 SenC CY96_10150 ENOG4105CAQ asparagine synthetase CY96_10165 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CY96_10170 ENOG4108MES Periplasmic binding protein CY96_10175 ENOG4105F0I Aminotransferase CY96_10205 ENOG4105D8X mechanosensitive ion channel CY96_10210 ENOG4105BZU Histidine kinase CY96_10215 ENOG4105WH1 Two component transcriptional regulator luxr family CY96_10220 ENOG4106KNT transcriptional regulator CY96_10225 ENOG4107ZY0 Phenazine biosynthesis-like protein CY96_10245 ENOG4105CMG Carbohydrate kinase CY96_10250 ENOG4105C6Z Gluconate CY96_10285 ENOG4108IJ8 ABC transporter CY96_10290 ENOG4105E90 ABC transporter CY96_10325 ENOG4105C37 (CBS) domain CY96_10350 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CY96_10365 ENOG4107S4Y M20 DapE family protein YgeY CY96_10370 ENOG4108TSC N-acetyltransferase CY96_10375 ENOG4108JUB Transcriptional regulator CY96_10380 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CY96_10425 ENOG410841Q phosphoesterase PA-phosphatase related protein CY96_10440 ENOG4105SZ6 Thioredoxin CY96_10475 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CY96_10535 ENOG4105BZ4 penicillin-binding protein CY96_10545 ENOG4105CZM Major Facilitator CY96_10550 ENOG4105W8X HesB YadR YfhF-family protein CY96_10560 ENOG4105DXD 2-methylcitrate dehydratase CY96_10565 ENOG4105CR4 methylisocitrate lyase CY96_10570 ENOG4105C1G acyl-Coa dehydrogenase CY96_10575 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CY96_10585 ENOG4105N14 lysine exporter protein LysE YggA CY96_10590 ENOG4105E39 Enoyl-CoA hydratase CY96_10605 ENOG4107RFY SbcCD D subunit CY96_10610 ENOG4105EYH Exonuclease CY96_10630 ENOG4105FCD Major Facilitator CY96_10635 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CY96_10640 ENOG4105E4F Isochorismate synthase CY96_10645 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CY96_10650 ENOG4105WQI isochorismatase CY96_10655 ENOG4105CEY Amp-dependent synthetase and ligase CY96_10660 ENOG4105WQT MbtH domain protein CY96_10665 ENOG4105C0R drug resistance transporter emrb qaca subfamily CY96_10680 ENOG4105K70 DNA-binding protein CY96_10700 ENOG4105BZG amino acid carrier protein CY96_10720 ENOG4105FE9 pseudouridine synthase CY96_10725 ENOG4105C22 threonyL-tRNA synthetase CY96_10730 ENOG4105C19 ABC transporter CY96_10765 ENOG41081I9 integral membrane protein CY96_10775 ENOG4108Y4K DNA-binding transcriptional activator CY96_10790 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CY96_10800 ENOG4105EYF MMPL domain protein CY96_10825 ENOG4105WCN acetyltransferase CY96_10850 ENOG4105C1Q protoporphyrinogen oxidase CY96_10860 ENOG41068WN CY96_10890 ENOG4107V2S Transcriptional regulator CY96_10895 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CY96_10915 ENOG4105DND Transcriptional regulator CY96_10920 ENOG4108RPX mosc domain containing protein CY96_10935 ENOG4105BZ1 (ABC) transporter CY96_10940 ENOG4105BZ1 (ABC) transporter CY96_11000 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) CY96_11005 ENOG4108KPJ rna polymerase sigma factor CY96_11030 ENOG4105F32 YngK protein CY96_11055 ENOG4105RD7 BadF BadG BcrA BcrD CY96_11060 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CY96_11070 ENOG4105C7B Threonine dehydratase CY96_11075 ENOG4108INS Transcriptional regulator CY96_11090 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CY96_11095 ENOG4105C1J atp-dependent rna helicase CY96_11120 ENOG4108RZE Tetr family transcriptional regulator CY96_11150 ENOG41088CC tellurite resistance protein tehB CY96_11160 ENOG4108I0C methyltransferase CY96_11165 ENOG4107RA9 decarboxylase CY96_11170 ENOG4105K56 Transcriptional regulator CY96_11175 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CY96_11200 ENOG4105CIN aminoacyl-histidine dipeptidase CY96_11225 ENOG4105KRN Transcriptional regulator, abrb family CY96_11235 ENOG4105EJ9 Membrane CY96_11240 ENOG4105EQK -acetyltransferase CY96_11355 ENOG4105EJQ L-serine dehydratase CY96_11360 ENOG4105C44 Serine transporter CY96_11380 ENOG4105F6S Spore photoproduct lyase CY96_11385 ENOG4108NHD germination protein CY96_11395 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CY96_11400 ENOG4105CNI cell division protein FtsW CY96_11405 ENOG4105CJW magnesium transporter CY96_11415 ENOG4107RVG penicillin-binding protein CY96_11430 ENOG4107RF6 penicillin-binding protein CY96_11435 ENOG4107RF6 penicillin-binding protein CY96_11445 ENOG4105DIN metallophosphoesterase CY96_11455 ENOG4105CJ1 ABC, transporter CY96_11465 ENOG4107Z3H Transcriptional regulator, TetR family CY96_11480 ENOG4105C1G acyl-Coa dehydrogenase CY96_11485 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CY96_11490 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CY96_11495 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CY96_11500 ENOG4105E39 Enoyl-CoA hydratase CY96_11505 ENOG4107QX3 carboxylase CY96_11510 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CY96_11530 ENOG4105DBI uridine monophosphokinase CY96_11550 ENOG4105DZ1 carboxypeptidase CY96_11565 ENOG4105T9C HD domain CY96_11570 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CY96_11590 ENOG41075H3 AraC family transcriptional regulator CY96_11620 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CY96_11645 ENOG4107Y80 Major Facilitator superfamily CY96_11650 ENOG41089UC methyltransferase, type 11 CY96_11695 ENOG4105EFA 4-hydroxyphenylacetate CY96_11705 ENOG4105CPQ Dehydrogenase CY96_11715 ENOG410900G Protein of unknown function (DUF421) CY96_11720 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CY96_11730 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein CY96_11800 ENOG4105D6E homoserine dehydrogenase CY96_11810 ENOG4105CPF Cell wall formation (By similarity) CY96_11815 ENOG4105ETU transcriptional activator (TenA CY96_11920 ENOG410667J hydrolase CY96_11925 ENOG4105BZU Histidine kinase CY96_11930 ENOG4107RF6 penicillin-binding protein CY96_11955 ENOG4108JJB ABC transporter CY96_11970 ENOG4108HGU Histidine kinase CY96_11975 ENOG4105VTR Integrase CY96_12040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CY96_12045 ENOG4105GR3 Histidine kinase CY96_12050 ENOG4105CB2 alcohol dehydrogenase CY96_12055 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CY96_12060 ENOG4105CJN penicillin-binding protein CY96_12100 ENOG4105F27 Major Facilitator CY96_12105 ENOG4107Y80 Major Facilitator superfamily CY96_12125 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CY96_12150 ENOG4107Y9U Membrane CY96_12195 ENOG4105FCD Major Facilitator CY96_12205 ENOG4105E09 nadh pyrophosphatase CY96_12210 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CY96_12240 ENOG4108XI2 Domain of unknown function (DUF1963) CY96_12265 ENOG4105KWG Pfam:DUF1696 CY96_12275 ENOG4108YYS metal-dependent hydrolase (By similarity) CY96_12290 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CY96_12300 ENOG4105PKS Excinuclease abc c subunit domain protein CY96_12340 ENOG4107VFR oxidoreductase CY96_12365 ENOG4105U0R haloacid dehalogenase-like hydrolase CY96_12370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CY96_12375 ENOG4105BZU Histidine kinase CY96_12395 ENOG4107WD8 ABC transporter, permease CY96_12410 ENOG4105DY8 decarboxylase CY96_12425 ENOG4108IUM Glycogen debranching enzyme CY96_12435 ENOG4105CGH 5'-nucleotidase CY96_12450 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CY96_12455 ENOG4105FDR Membrane CY96_12460 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CY96_12515 ENOG4105MSI germination protein ypeb CY96_12545 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) CY96_12550 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) CY96_12555 ENOG4107Z3H Transcriptional regulator, TetR family CY96_12585 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CY96_12600 ENOG4105E98 transcriptional regulator DeoR family CY96_12615 ENOG41062ES Transcriptional regulator CY96_12635 ENOG4107QKR Dehydrogenase CY96_12645 ENOG4107RUY (E1 component), alpha subunit CY96_12660 ENOG4105E1F short-chain dehydrogenase reductase CY96_12665 ENOG4105RHY Pfam:UPF0157 CY96_12670 ENOG4105E09 nadh pyrophosphatase CY96_12695 ENOG4107SQ8 Glycine betaine CY96_12700 ENOG4108IJ7 Glycine betaine CY96_12725 ENOG4105E66 phosphoriboisomerase A CY96_12730 ENOG41082BV acetyltransferase CY96_12735 ENOG4108M1A Chitin-binding protein CY96_12765 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CY96_12770 ENOG4105MSB protein, conserved in bacteria CY96_12795 ENOG4108Z7F N-acetyltransferase CY96_12825 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CY96_12830 ENOG4105EEM helicase CY96_12845 ENOG4105C9U ATP-dependent DNA helicase RecQ CY96_12895 ENOG4108M1A Chitin-binding protein CY96_12910 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CY96_12925 ENOG4105C26 Dehydrogenase CY96_12930 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CY96_12940 ENOG4105CTU Proline racemase CY96_12945 ENOG41080HI glycine oxidase CY96_12955 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein CY96_12995 ENOG4105DCI Phosphohydrolase CY96_13000 ENOG4107T5V SNARE associated Golgi CY96_13010 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CY96_13030 ENOG4105DTQ mandelate racemase muconate lactonizing CY96_13045 ENOG4107SET aldo keto reductase CY96_13085 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) CY96_13090 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CY96_13095 ENOG4105BZU Histidine kinase CY96_13100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CY96_13120 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 CY96_13135 ENOG4105DPN Oligoendopeptidase f CY96_13140 ENOG4105EPR degv family CY96_13210 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CY96_13215 ENOG4106K7D Major facilitator family transporter CY96_13235 ENOG4107BMA Transglycosylase associated protein CY96_13250 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CY96_13295 ENOG4105CHM Aminotransferase CY96_13310 ENOG4108ZMI UPF0477 protein CY96_13325 ENOG4105DVE abc transporter atp-binding protein CY96_13375 ENOG4105C02 permease CY96_13390 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CY96_13395 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CY96_13400 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein CY96_13405 ENOG4105D7T ABC transporter CY96_13435 ENOG4108AQF aminoglycoside N(3)-acetyltransferase CY96_13475 ENOG4107VC0 DNA alkylation repair enzyme CY96_13485 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase CY96_13495 ENOG4107VMI polysaccharide deacetylase CY96_13500 ENOG4108ZCF integral membrane protein CY96_13505 ENOG4105E0M Sulfatase CY96_13515 ENOG4105C5H ABC transporter CY96_13525 ENOG4105EYF MMPL domain protein CY96_13530 ENOG41082JN Transcriptional regulator CY96_13560 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CY96_13565 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CY96_13605 ENOG41069ER domain protein CY96_13615 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase CY96_13645 ENOG4105D4B ABC, transporter CY96_13650 ENOG4105F5R ABC transporter CY96_13655 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane CY96_13665 ENOG4105DKT Transcriptional regulator CY96_13670 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) CY96_13680 ENOG41061GT Aldolase CY96_13690 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) CY96_13725 ENOG4105II7 pyrroline-5-carboxylate reductase CY96_13735 ENOG4107258 Transcriptional regulator CY96_13750 ENOG4105ECK Fatty Acid Desaturase CY96_13760 ENOG4107RBI VanW family CY96_13765 ENOG4105G6Z alkaline phosphatase CY96_13775 ENOG4105VMP Transcriptional regulator CY96_13800 ENOG41068WN CY96_13830 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CY96_13855 ENOG4105CKK Glycosyl transferase, family 2 CY96_13885 ENOG4105C8Y Acetylornithine aminotransferase CY96_13930 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CY96_13970 ENOG4108TVJ Nitroreductase CY96_13975 ENOG4105FS7 Transcriptional regulator CY96_13990 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CY96_13995 ENOG4105WEC Molybdate metabolism regulator CY96_14005 ENOG4105CMR udp-glucose 4-epimerase CY96_14010 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CY96_14035 ENOG4108DMH HTH_ARAC CY96_14040 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CY96_14045 ENOG4108XET gCN5-related N-acetyltransferase CY96_14060 ENOG4108PCN EamA-like transporter family CY96_14070 ENOG4107XJU UPF0178 protein CY96_14110 ENOG410635A Membrane CY96_14120 ENOG4108IQI permease CY96_14130 ENOG4105F1N DNA alkylation repair CY96_14165 ENOG4107RF6 penicillin-binding protein CY96_14175 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CY96_14195 ENOG4105E7W lamb ycsf family protein CY96_14205 ENOG4105P4J Allophanate hydrolase, subunit 1 CY96_14210 ENOG4107258 Transcriptional regulator CY96_14220 ENOG4106N3A copper homeostasis protein cutc CY96_14230 ENOG4108ZHR arsR family transcriptional regulator CY96_14240 ENOG4105FDT acyl-CoA dehydrogenase CY96_14260 ENOG4105DWD nucleoside recognition domain protein CY96_14295 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CY96_14305 ENOG4105CAQ asparagine synthetase CY96_14310 ENOG4105DND Transcriptional regulator CY96_14345 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CY96_14370 ENOG4105E2A Dehydrogenase CY96_14380 ENOG4108IJ0 Aspartate ammonia-lyase CY96_14385 ENOG4105HDK L-asparaginase CY96_14390 ENOG4108IMY Transcriptional regulator CY96_14400 ENOG4108B31 Spore germination protein CY96_14430 ENOG4105BZU Histidine kinase CY96_14435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CY96_14445 ENOG4105BZU Histidine kinase CY96_14470 ENOG41075H3 AraC family transcriptional regulator CY96_14480 ENOG4105YWU small acid-soluble spore protein CY96_14485 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CY96_14490 ENOG4105CUB amino acid CY96_14495 ENOG4105II7 pyrroline-5-carboxylate reductase CY96_14500 ENOG4108NHD germination protein CY96_14505 ENOG4108Q8B Spore germination protein CY96_14560 ENOG4105CGH 5'-nucleotidase CY96_14570 ENOG4105CHJ isochorismatase hydrolase CY96_14595 ENOG4105EQ0 Major Facilitator superfamily CY96_14640 ENOG4105F6J Alpha beta hydrolase fold CY96_14655 ENOG4108606 TspO/MBR family CY96_14660 ENOG4105CVP deoxyribo-dipyrimidine photolyase CY96_14670 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) CY96_14700 ENOG4105F2M alpha beta hydrolase fold-3 domain protein CY96_14715 ENOG4108TWJ NADH dehydrogenase subunit 5 CY96_14720 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CY96_14725 ENOG4105C0R drug resistance transporter emrb qaca subfamily CY96_14745 ENOG4107VMI polysaccharide deacetylase CY96_14750 ENOG4105KY5 gCN5-related N-acetyltransferase CY96_14755 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CY96_14760 ENOG4105ECQ AraC Family Transcriptional Regulator CY96_14780 ENOG4105D6J arsenicaL-resistance protein CY96_14785 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase CY96_14790 ENOG41085FC arsR family transcriptional regulator CY96_14800 ENOG410667J hydrolase CY96_14805 ENOG4107P5I polyketide synthase CY96_14810 ENOG4108IG5 Transcriptional regulator CY96_14870 ENOG4108NIW Leucine export protein LeuE CY96_14915 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CY96_14920 ENOG4105C0R drug resistance transporter emrb qaca subfamily CY96_14940 ENOG4105K6H D-cysteine desulfhydrase CY96_14950 ENOG4105E0Y RtcB Protein CY96_14960 ENOG4105JQZ Methyltransferase CY96_14980 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) CY96_14995 ENOG4105BZU Histidine kinase CY96_15005 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CY96_15040 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CY96_15075 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CY96_15490 ENOG4108VXD carboxy-peptidase CY96_15495 ENOG4105PNM synthesis protein CY96_15505 ENOG4108ISG Major Facilitator CY96_15520 ENOG4107MII Sugar-specific transcriptional regulator TrmB CY96_15525 ENOG4105CZM Major Facilitator CY96_15535 ENOG4105CRW Short chain fatty acid transporter CY96_15605 ENOG4108K8S endonuclease I CY96_15625 ENOG4108Z66 YbaK ebsC protein CY96_15630 ENOG4105CUT histidyl-tRNA synthetase CY96_15645 ENOG4105KVH Transcriptional regulator CY96_15650 ENOG4108RCM Nitroreductase CY96_15680 ENOG4108PSK reductase CY96_15740 ENOG4105C31 Tryptophanyl-tRNA synthetase CY96_15745 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CY96_15780 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) CY96_15790 ENOG4105EV4 Multidrug resistance protein mdtH CY96_15820 ENOG4105C37 (CBS) domain CY96_15835 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CY96_15840 ENOG4105FAW cDP-glucose 4,6-dehydratase CY96_15875 ENOG4105DDN Pentapeptide repeat-containing protein CY96_15880 ENOG4105XDF Protein of unknown function (DUF1272) CY96_15885 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CY96_15890 ENOG4105CMG Carbohydrate kinase CY96_15895 ENOG4105C6Z Gluconate CY96_15900 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CY96_15910 ENOG4105CV1 Transketolase (EC 2.2.1.1) CY96_15915 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CY96_15935 ENOG4105C8Q Methyl-accepting chemotaxis CY96_15945 ENOG4108UX3 '-nucleotidase CY96_15950 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CY96_15955 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) CY96_15960 ENOG4105KVH Transcriptional regulator CY96_15985 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CY96_15990 ENOG4105CHH sulfate transporter CY96_16005 ENOG4105C44 Serine transporter CY96_16030 ENOG4108TZY GntR Family Transcriptional Regulator CY96_16035 ENOG4105D9R oxidoreductase CY96_16075 ENOG4105JAB phenazine biosynthesis protein, phzf family CY96_16090 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CY96_16095 ENOG4105KVH Transcriptional regulator CY96_16110 ENOG4108ZJ4 polysaccharide deacetylase CY96_16175 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) CY96_16205 ENOG4105H3G oxidoreductase CY96_16275 ENOG4108TN2 lmbE family CY96_16285 ENOG4107R3E Citrate transporter CY96_16295 ENOG4105WCN acetyltransferase CY96_16300 ENOG4108MES Periplasmic binding protein CY96_16305 ENOG4105EHG Permease protein CY96_16310 ENOG4105DQ5 transport system permease protein CY96_16315 ENOG4105NX3 Membrane CY96_16335 ENOG4107CUJ Protein of unknown function (DUF2690) CY96_16345 ENOG4107V2S Transcriptional regulator CY96_16375 ENOG4105C98 muts2 protein CY96_16385 ENOG4105E5K Alpha-amylase CY96_16390 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CY96_16395 ENOG4105DPN Oligoendopeptidase f CY96_16400 ENOG4108A04 Beta-lactamase CY96_16425 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CY96_16440 ENOG41082BM Transcriptional regulator, arsr family CY96_16445 ENOG4105CIS alcohol dehydrogenase CY96_16470 ENOG4105RHY Pfam:UPF0157 CY96_16485 ENOG4105CQB FAD linked oxidase domain protein CY96_16510 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CY96_16525 ENOG4107TPS domain protein CY96_16530 ENOG4105CEP NADH dehydrogenase CY96_16540 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CY96_16550 ENOG4108IAJ Nad-dependent epimerase dehydratase CY96_16555 ENOG4105FAW cDP-glucose 4,6-dehydratase CY96_16610 ENOG4105BZU Histidine kinase CY96_16615 ENOG4105C5H ABC transporter CY96_16635 ENOG4105BZU Histidine kinase CY96_16645 ENOG4105KT7 mgtC SapB transporter CY96_16655 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CY96_16660 ENOG41073R8 VanW family CY96_16670 ENOG4108R1P CY96_16690 ENOG4105VEQ Cold shock protein CY96_16730 ENOG410904N short-chain dehydrogenase reductase CY96_16740 ENOG4106IQC argininosuccinate lyase CY96_16755 ENOG4108IA2 Sodium pantothenate symporter CY96_16765 ENOG4105C26 Dehydrogenase CY96_16770 ENOG4105CHR reductase CY96_16780 ENOG4105EWU Squalene--hopene cyclase CY96_16790 ENOG4105FR1 rard protein CY96_16795 ENOG410696E Membrane CY96_16810 ENOG4105D1F ATP-binding protein CY96_16820 ENOG4108ZAF Molybdopterin CY96_16825 ENOG4105CVM Molybdenum cofactor synthesis domain protein CY96_16830 ENOG4105D06 uba thif-type nad fad binding protein CY96_16835 ENOG4105TMB Formate nitrite transporter CY96_16845 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CY96_16850 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) CY96_16860 ENOG4108JB9 formate dehydrogenase CY96_16865 ENOG4105E1K spore germination protein CY96_16880 ENOG4105CUB amino acid CY96_16935 ENOG4108KGH TRANSCRIPTIONal CY96_16945 ENOG4105EMN RNA polymerase sigma factor CY96_16955 ENOG4105CIG ABC transporter CY96_16965 ENOG4105D9R oxidoreductase CY96_16975 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CY96_16980 ENOG4105K4P CoA-binding domain protein CY96_16985 ENOG4105C0H protease CY96_16990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CY96_16995 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) CY96_17000 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CY96_17005 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CY96_17010 ENOG4105W8X HesB YadR YfhF-family protein CY96_17040 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CY96_17045 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CY96_17060 ENOG4105BZ1 (ABC) transporter CY96_17065 ENOG4108I0Z Aconitate hydratase CY96_17095 ENOG4105E5W Transporter CY96_17105 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CY96_17125 ENOG4107F3J Amp-dependent synthetase and ligase CY96_17130 ENOG4107ZYJ bioY protein CY96_17135 ENOG4105CEY Amp-dependent synthetase and ligase CY96_17140 ENOG4108IMY Transcriptional regulator CY96_17180 ENOG4107AYK membrAne CY96_17190 ENOG4105BZU Histidine kinase CY96_17195 ENOG4105FBA Phospholipase Carboxylesterase CY96_17200 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CY96_17210 ENOG4105CBC glutamate synthase CY96_17215 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CY96_17220 ENOG4108VJ1 Transcriptional regulator (CarD family CY96_17225 ENOG4108903 Formimidoylglutamase CY96_17235 ENOG4105CGP Urocanate hydratase CY96_17250 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) CY96_17280 ENOG4107QIV Cytochrome c biogenesis protein CY96_17295 ENOG4105CH2 amidohydrolase CY96_17305 ENOG4105CJ1 ABC, transporter CY96_17320 ENOG4107RSM transcriptional regulator CY96_17325 ENOG4105VAW lrga family CY96_17330 ENOG41067MG lrgb family CY96_17370 ENOG4105BZ1 (ABC) transporter CY96_17375 ENOG4105BZ1 (ABC) transporter CY96_17410 ENOG4108HW3 (ABC) transporter CY96_17415 ENOG4105CGH 5'-nucleotidase CY96_17425 ENOG4108SVB resolvase CY96_17445 ENOG4105K7K Transcriptional regulator CY96_17465 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CY96_17485 ENOG4105DR5 peptidase CY96_17490 ENOG41065S2 pneumococcal vaccine antigen CY96_17525 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CY96_17530 ENOG4105C5F glutamine synthetase CY96_17535 ENOG4105KV4 Transcriptional regulator CY96_17540 ENOG4105CXI aluminum resistance protein CY96_17545 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CY96_17550 ENOG4105EN6 Membrane CY96_17560 ENOG4106F1P AAA ATPase, central domain protein CY96_17595 ENOG41069ER domain protein CY96_17600 ENOG4105DM4 PTS System CY96_17605 ENOG4105DE4 1-phosphofructokinase CY96_17610 ENOG4105E98 transcriptional regulator DeoR family CY96_17615 ENOG4107QW4 alcohol dehydrogenase CY96_17620 ENOG4108SJC Membrane CY96_17635 ENOG4105C85 amino acid CY96_17650 ENOG4105TMB Formate nitrite transporter CY96_17655 ENOG4105K70 DNA-binding protein CY96_17665 ENOG4105C59 p-type ATPase CY96_17670 ENOG410681U heavy metal transport detoxification protein CY96_17675 ENOG4105VPX protein, conserved in bacteria CY96_17685 ENOG4105D01 (LipO)protein CY96_17690 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase CY96_17695 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CY96_17700 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CY96_17705 ENOG4108R6W Transcriptional regulator, ARAC family CY96_17710 ENOG4106AM8 polysaccharide lyase family 8 CY96_17720 ENOG4105EP8 Glycosyl Hydrolase Family 88 CY96_17725 ENOG4108EQA pts system CY96_17730 ENOG4105F3R pts system mannose fructose sorbose family iid CY96_17735 ENOG4105ETZ PTS System CY96_17745 ENOG4105CHR reductase CY96_17750 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) CY96_17765 ENOG4106P37 HTH-type transcriptional regulator YjhI CY96_17775 ENOG4105NIV Esterase CY96_17780 ENOG4105E0A ABC, transporter CY96_17805 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CY96_17810 ENOG4105D03 DNA-3-methyladenine glycosylase II CY96_17835 ENOG4105BZU Histidine kinase CY96_17855 ENOG4105C5E polysaccharide biosynthesis protein CY96_17870 ENOG41067MG lrgb family CY96_17890 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C CY96_17900 ENOG4105F0V Cell wall hydrolase CY96_17910 ENOG4105E0M Sulfatase CY96_17915 ENOG410890F Dynamin family CY96_17950 ENOG4105DQU oxidoreductase, subunit beta CY96_17955 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CY96_17960 ENOG4108IGT Dipeptidase CY96_17965 ENOG4105MCT stage V sporulation protein S CY96_17970 ENOG4105D48 metallophosphoesterase CY96_17990 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CY96_18005 ENOG4105XZV Protein of unknown function (DUF3243) CY96_18010 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CY96_18030 ENOG4105UIB (ABC) transporter CY96_18035 ENOG4108JQ9 ABC transporter CY96_18040 ENOG4105DIH basic membrane CY96_18045 ENOG4105FDP GntR family transcriptional regulator CY96_18050 ENOG4105CNU cell division protein FtsK CY96_18060 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CY96_18070 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CY96_18080 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CY96_18085 ENOG4108S0H Dipicolinic acid synthetase, b subunit CY96_18090 ENOG4105E35 Dipicolinate synthase subunit A CY96_18100 ENOG4105C1V Peptidase, M16 CY96_18120 ENOG4105DTN riboflavin biosynthesis protein ribF CY96_18135 ENOG4105W7A Protein of unknown function (DUF503) CY96_18145 ENOG4105VHM ribosomal protein CY96_18150 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CY96_18155 ENOG4105CHV Transcription elongation factor NusA CY96_18165 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CY96_18175 ENOG4105DZP Membrane-associated zinc metalloprotease CY96_18180 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CY96_18185 ENOG4105KNE Phosphatidate cytidylyltransferase CY96_18190 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CY96_18200 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CY96_18230 ENOG4108HE4 integrase family CY96_18240 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CY96_18245 ENOG4105C79 DNA protecting protein DprA CY96_18250 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CY96_18265 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CY96_18290 ENOG4105VB6 UPF0109 protein CY96_18310 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CY96_18315 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CY96_18330 ENOG4105CHR reductase CY96_18335 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CY96_18350 ENOG4105CB5 ATP-dependent DNA helicase recG CY96_18355 ENOG4105DP4 dak2 domain fusion protein ylov CY96_18360 ENOG4108ZAA Alkaline-shock protein CY96_18375 ENOG4105FJ0 thiamine CY96_18380 ENOG4105DJV ribulose-phosphate 3-epimerase CY96_18385 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CY96_18390 ENOG4105D9P serine threonine protein kinase CY96_18395 ENOG4108ZF3 Phosphatase CY96_18405 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CY96_18420 ENOG4105C25 Primosomal protein n' CY96_18425 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CY96_18445 ENOG4105DSJ YicC domain protein CY96_18455 ENOG4105F23 Fibronectin-binding protein CY96_18460 ENOG4105DC7 peptidase M24 CY96_18480 ENOG4107XGZ Hydrolase CY96_18500 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CY96_18535 ENOG4105C34 Pseudouridine synthase CY96_18550 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CY96_18560 ENOG4105DBK s4 domain protein CY96_18565 ENOG41067XK integral membrane protein CY96_18575 ENOG4105DFA alanine racemase domain protein CY96_18580 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CY96_18585 ENOG4105WR5 sporulation protein, YlmC YmxH family CY96_18595 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CY96_18605 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CY96_18610 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CY96_18625 ENOG4105D4A Cell wall formation (By similarity) CY96_18630 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CY96_18635 ENOG4105CNI cell division protein FtsW CY96_18650 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CY96_18655 ENOG4105CJN penicillin-binding protein CY96_18660 ENOG4105CJN penicillin-binding protein CY96_18675 ENOG41074B2 UPF0747 protein CY96_18700 ENOG4105KNH Nucleic acid-binding protein CY96_18710 ENOG41063PX domain protein CY96_18715 ENOG4105D78 K07001 NTE family protein CY96_18720 ENOG4105H20 Sporulation integral membrane protein YlbJ CY96_18730 ENOG4106H78 methyltransferase CY96_18750 ENOG4107TB6 phosphoglycerate mutase CY96_18765 ENOG4106UY4 Inherit from COG: Scp-like extracellular CY96_18815 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CY96_18820 ENOG4105CNI cell division protein FtsW CY96_18835 ENOG4108IAB Phoh family CY96_18855 ENOG4105QA2 CY96_18860 ENOG4105CI3 gtp-binding protein typa CY96_18870 ENOG4105ECY inositol monophosphatase CY96_18890 ENOG4105CXN decarboxylase CY96_18940 ENOG4105CPP Dehydrogenase, E1 component CY96_18955 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CY96_18960 ENOG4108X4Q Hydrolase CY96_18970 ENOG4105CN5 Metallo-Beta-Lactamase CY96_18975 ENOG4107ZYR domain protein CY96_19010 ENOG4108XRC Protein of unknown function (DUF458) CY96_19020 ENOG4107IN1 Protein of unknown function (DUF1797) CY96_19035 ENOG4105EPM Diguanylate phosphodiesterase CY96_19040 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CY96_19055 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CY96_19065 ENOG4105UIN CY96_19100 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CY96_19120 ENOG4108HGU Histidine kinase CY96_19130 ENOG4105CHM Aminotransferase CY96_19135 ENOG4105FKQ transcriptional regulator CY96_19140 ENOG4105EG2 ABC transporter, permease CY96_19150 ENOG4107FKK extracellular solute-binding protein family 1 CY96_19160 ENOG4105CG3 alpha amylase, catalytic region CY96_19205 ENOG4105CHU acetyl-coa acetyltransferase CY96_19235 ENOG4105K7K Transcriptional regulator CY96_19240 ENOG4105DTD Dehydrogenase CY96_19260 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CY96_19285 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CY96_19300 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CY96_19310 ENOG4105BZU Histidine kinase CY96_19330 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CY96_19345 ENOG4105CID antiterminator CY96_19355 ENOG4105FDP GntR family transcriptional regulator CY96_19365 ENOG4105CE4 GlcNAc 6-P deacetylase CY96_19400 ENOG4107ZE5 PPIases accelerate the folding of proteins CY96_19405 ENOG4105PTM secreted protein CY96_19410 ENOG4105J7I hydrolase CY96_19420 ENOG4105G6R Stage v sporulation protein ae CY96_19430 ENOG4105CZ3 stage V sporulation protein ad CY96_19435 ENOG41090VF Stage v sporulation protein ac CY96_19455 ENOG4105C8J )-transporter CY96_19460 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CY96_19470 ENOG41082AN stage II sporulation protein CY96_19475 ENOG4105DZ1 carboxypeptidase CY96_19480 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CY96_19485 ENOG4105DVE abc transporter atp-binding protein CY96_19515 ENOG4105D7N magnesium and cobalt transport protein CorA CY96_19540 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CY96_19550 ENOG4105I3K Ferric uptake regulator, Fur family CY96_19555 ENOG4105MZ9 stage II sporulation protein m CY96_19575 ENOG4105CPC Aldo Keto reductase CY96_19585 ENOG4105RHY Pfam:UPF0157 CY96_19605 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CY96_19615 ENOG4105ETE Transcriptional regulator (LacI family CY96_19620 ENOG4108YM7 Gcn5-related n-acetyltransferase CY96_19640 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CY96_19645 ENOG4108R6K riboflavin synthase, subunit alpha CY96_19670 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CY96_19675 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CY96_19690 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CY96_19700 ENOG4105DFD Na H antiporter CY96_19705 ENOG4105CGH 5'-nucleotidase CY96_19730 ENOG4105DBV ornithine carbamoyltransferase CY96_19745 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CY96_19760 ENOG4108IXY short-chain dehydrogenase reductase CY96_19765 ENOG41069FQ Metallo-beta-lactamase superfamily CY96_19770 ENOG4105II7 pyrroline-5-carboxylate reductase CY96_19775 ENOG4105EJQ L-serine dehydratase CY96_19790 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CY96_19805 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CY96_19820 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CY96_19825 ENOG4105D9U N-acetyltransferase CY96_19840 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CY96_19845 ENOG4108QEG Membrane CY96_19850 ENOG4105CDA abc transporter atp-binding protein CY96_19855 ENOG4105E5Q amino acid AbC transporter CY96_19860 ENOG4108HW3 (ABC) transporter CY96_19870 ENOG4105G7B Protein of unknown function (DUF2992) CY96_19880 ENOG4108QY0 Membrane CY96_19890 ENOG4105C7S Dehydrogenase CY96_19895 ENOG4105CPP Dehydrogenase, E1 component CY96_19915 ENOG4107RDP Dehydrogenase CY96_19925 ENOG4108JUB Transcriptional regulator CY96_19935 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CY96_20045 ENOG4107QQR Sporulation CY96_20050 ENOG4105S1Z Stage IV sporulation protein B CY96_20055 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CY96_20060 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CY96_20065 ENOG4105DX0 Hemolysin A CY96_20075 ENOG4105CTB Polyprenyl synthetase CY96_20090 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CY96_20100 ENOG4108ZSR alkaline shock protein CY96_20105 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CY96_20125 ENOG410644B Stage III sporulation protein af CY96_20135 ENOG4105KQ4 Stage iii sporulation protein ad CY96_20140 ENOG4108CQH stage III sporulation protein AC CY96_20145 ENOG4105KR5 Stage iii sporulation protein CY96_20150 ENOG4105CD2 stage iii sporulation protein aa CY96_20175 ENOG4105DC7 peptidase M24 CY96_20180 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CY96_20190 ENOG4105CBJ Metal-dependent enzyme CY96_20200 ENOG4107YBY Hydrolase CY96_20225 ENOG41082GG biotin lipoate A B protein ligase CY96_20230 ENOG4105WZW rhodanese family CY96_20255 ENOG41080TC multidrug resistance protein CY96_20290 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CY96_20320 ENOG4105C0D helicase CY96_20440 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CY96_20445 ENOG4105C3R Methionine synthase CY96_20460 ENOG4105C28 cystathionine CY96_20465 ENOG4105C28 cystathionine CY96_20485 ENOG4105C5X domain protein CY96_20495 ENOG4105DKQ ROK family CY96_20505 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CY96_20520 ENOG4108UTW Plays a role in the regulation of phosphate uptake CY96_20525 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CY96_20530 ENOG4105C8U phosphate abc transporter CY96_20535 ENOG4105C8U phosphate abc transporter CY96_20545 ENOG4107RF6 penicillin-binding protein CY96_20555 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CY96_20580 ENOG4105N80 Ferric uptake regulator, Fur family CY96_20590 ENOG4105FDK ABC transporter CY96_20595 ENOG4108JYZ YitT family CY96_20600 ENOG41069ZM Protein of unknown function (DUF2624) CY96_20625 ENOG4105EGD dinuclear metal center protein, YbgI family CY96_20640 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CY96_20645 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CY96_20680 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CY96_20685 ENOG4105KG3 cytidine deaminase CY96_20690 ENOG4107YR5 Diacylglycerol kinase CY96_20700 ENOG4105CTJ Metal Dependent Phosphohydrolase CY96_20705 ENOG4105C9A Phoh family CY96_20715 ENOG41068P3 sporulation protein YqfC CY96_20720 ENOG4105KTH gatB Yqey CY96_20730 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CY96_20735 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CY96_20765 ENOG4105CSA Coproporphyrinogen iii oxidase CY96_20770 ENOG4105KVH Transcriptional regulator CY96_20795 ENOG4105TQK DNA polymerase iii, delta' subunit CY96_20805 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CY96_20810 ENOG4108UK2 deaminase CY96_20815 ENOG4105KQC Competence protein CY96_20825 ENOG4105DXX methyltransferase CY96_20835 ENOG4108WF2 Metal Dependent Phosphohydrolase CY96_20845 ENOG410812S Rna-binding protein CY96_20855 ENOG4105CQW ribosome biogenesis GTPase YqeH CY96_20860 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CY96_20875 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CY96_20895 ENOG4108TVJ Nitroreductase CY96_20910 ENOG4105G6Z alkaline phosphatase CY96_20915 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CY96_20920 ENOG4108MUZ hydrolase CY96_20955 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CY96_20965 ENOG4105MIR Phenylalanine 4-monooxygenase CY96_20975 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CY96_21015 ENOG4105S6R Iron-hydroxamate transporter permease subunit CY96_21020 ENOG4108V5C ABC transporter CY96_21030 ENOG4108EKI Dehydrogenase CY96_21035 ENOG4105C28 cystathionine CY96_21065 ENOG4107XRG penicillin-binding protein CY96_21075 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CY96_21085 ENOG4105CFP Peptidase U32 CY96_21090 ENOG4105XYU peptidase (U32 family) CY96_21095 ENOG4108VQJ O-methyltransferase CY96_21100 ENOG4105HHA aminodeoxychorismate lyase CY96_21120 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CY96_21130 ENOG4105C02 permease CY96_21145 ENOG41060CR CY96_21150 ENOG4105C7H Helicase, RecD TraA family CY96_21160 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CY96_21165 ENOG4105C3J Cysteine desulfurase CY96_21175 ENOG4105D1H recombination factor protein RarA CY96_21180 ENOG4108VCI transcription factor, rsfa family CY96_21195 ENOG4105CUZ uba thif-type nad fad binding protein CY96_21205 ENOG4105CUT histidyl-tRNA synthetase CY96_21215 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CY96_21220 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CY96_21230 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CY96_21235 ENOG41076HS cation diffusion facilitator family transporter CY96_21240 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CY96_21250 ENOG4105CKP Polysaccharide Biosynthesis Protein CY96_21255 ENOG4108QG2 Membrane CY96_21265 ENOG4105VIE preprotein translocase, subunit YajC CY96_21295 ENOG4108HUF Transporter CY96_21325 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CY96_21330 ENOG4108IYU L-aspartate oxidase CY96_21345 ENOG4108RPX mosc domain containing protein CY96_21355 ENOG4105CQC Prephenate dehydratase CY96_21370 ENOG4105C19 ABC transporter CY96_21375 ENOG4105EWM Histidine kinase CY96_21385 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CY96_21400 ENOG4105X36 (ribosomal) protein CY96_21410 ENOG4105C03 ribonuclease CY96_21425 ENOG4107QMS site-determining protein CY96_21440 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CY96_21445 ENOG4105DFF Rod shape-determining protein mreb CY96_21465 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CY96_21470 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CY96_21480 ENOG41068KH stage VI sporulation protein D CY96_21490 ENOG4105D52 delta-aminolevulinic acid dehydratase CY96_21515 ENOG4105K56 Transcriptional regulator CY96_21535 ENOG4108IUQ atp-dependent protease CY96_21560 ENOG4108QCI YvbH-like oligomerisation region CY96_21605 ENOG4105M59 Phosphodiesterase, mj0936 family CY96_21610 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CY96_21620 ENOG4108XJQ germination protein CY96_21635 ENOG4105PFC Transcriptional regulator CY96_21650 ENOG4105DZC cytosine deaminase CY96_21655 ENOG41067S9 phage shock protein C, PspC CY96_21660 ENOG4108JCI Transcriptional regulator CY96_21670 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CY96_21675 ENOG4108Z40 Transcriptional regulator CY96_21680 ENOG4105RHA ABC transporter, permease CY96_21685 ENOG4108IUX (ABC) transporter CY96_21690 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family CY96_21695 ENOG4105ER2 Ompa motb domain protein CY96_21700 ENOG4105E14 MotA TolQ exbB proton channel CY96_21705 ENOG4108VXD carboxy-peptidase CY96_21715 ENOG4105E33 succinate dehydrogenase CY96_21725 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CY96_21735 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CY96_21740 ENOG4105K63 Thioredoxin CY96_21745 ENOG4105C10 Electron transfer flavoprotein CY96_21750 ENOG4105BZJ Electron transfer flavoprotein CY96_21755 ENOG41060WC Enoyl-CoA hydratase CY96_21760 ENOG4107Z3H Transcriptional regulator, TetR family CY96_21765 ENOG4105CEY Amp-dependent synthetase and ligase CY96_21775 ENOG4105J76 Periplasmic binding protein CY96_21780 ENOG4105S6R Iron-hydroxamate transporter permease subunit CY96_21830 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CY96_21845 ENOG4105DR4 Methyltransferase CY96_21855 ENOG4105KFN sortase, SrtB family CY96_21860 ENOG4105E0A ABC, transporter CY96_21875 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) CY96_21885 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) CY96_21895 ENOG4105FE9 pseudouridine synthase CY96_21910 ENOG4105DCG PHP domain protein CY96_21925 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CY96_21945 ENOG4105C5S asparaginyl-tRNA synthetase CY96_21950 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CY96_21960 ENOG4108RWN rrna methyltransferase CY96_21990 ENOG4105C0R drug resistance transporter emrb qaca subfamily CY96_21995 ENOG4105CW7 secretion protein, HlyD family CY96_22000 ENOG4108JGH Tetr family transcriptional regulator CY96_22005 ENOG4105CN9 Peptidase m42 family protein CY96_22025 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CY96_22030 ENOG4105C22 threonyL-tRNA synthetase CY96_22035 ENOG4108TDW sporulation protein YtxC CY96_22060 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CY96_22065 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CY96_22070 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CY96_22080 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CY96_22085 ENOG4105C2M dna polymerase I CY96_22090 ENOG4105BZU Histidine kinase CY96_22095 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CY96_22120 ENOG4108HMX isocitrate dehydrogenase (NADP) CY96_22125 ENOG4105BZN citrate synthase CY96_22135 ENOG4108REF Sporulation integral membrane protein ytvi CY96_22140 ENOG4105FS0 cytoplasmic membrane protein CY96_22165 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CY96_22170 ENOG4105C6K Malic enzyme CY96_22175 ENOG4105C0B DNA polymerase III (alpha subunit) CY96_22180 ENOG4105VV2 CY96_22190 ENOG4105SFS phosphoesterase RecJ domain protein CY96_22220 ENOG4105DC7 peptidase M24 CY96_22250 ENOG41082W1 Cupin 2, conserved barrel domain protein CY96_22270 ENOG4107YZX Universal stress protein CY96_22310 ENOG4108JYZ YitT family CY96_22330 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CY96_22340 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CY96_22345 ENOG4105KBJ sporulation protein ytfj CY96_22360 ENOG4105EFZ amidohydrolase CY96_22370 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CY96_22395 ENOG4105RQF LysR family Transcriptional regulator CY96_22405 ENOG4105U5Y Transcriptional regulator CY96_22415 ENOG4105C28 cystathionine CY96_22470 ENOG4105EMN RNA polymerase sigma factor CY96_22480 ENOG4108UW5 maltose o-acetyltransferase CY96_22490 ENOG4105F1V Acetoin utilization protein CY96_22495 ENOG4105W87 Cbs domain CY96_22500 ENOG4105DGU Histone deacetylase CY96_22515 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CY96_22520 ENOG4105BZU Histidine kinase CY96_22525 ENOG4107SNB ankyrin repeat protein YahD CY96_22530 ENOG4105EP9 oxidoreductase CY96_22550 ENOG4105ETE Transcriptional regulator (LacI family CY96_22555 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CY96_22575 ENOG4105C88 aminopeptidase CY96_22620 ENOG4108VDD TRNA binding domain protein CY96_22650 ENOG4105C8F Beta-lactamase domain protein CY96_22665 ENOG4108V15 phosphotransferase enzyme family CY96_22670 ENOG4108IUM Glycogen debranching enzyme CY96_22680 ENOG4107QSE Dipeptidase CY96_22685 ENOG4105YW5 deoR family transcriptional regulator CY96_22700 ENOG4105CBX hi0933 family CY96_22735 ENOG4108VJ1 Transcriptional regulator (CarD family CY96_22740 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CY96_22745 ENOG4105CSC Glucose uptake protein CY96_22760 ENOG4108ZAF Molybdopterin CY96_22765 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CY96_22770 ENOG4105CVM Molybdenum cofactor synthesis domain protein CY96_22780 ENOG4105D06 uba thif-type nad fad binding protein CY96_22785 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CY96_22810 ENOG41085GJ domain protein CY96_22820 ENOG4105DWV Homoserine O-trans-acetylase CY96_22830 ENOG4108B31 Spore germination protein CY96_22860 ENOG4105C8T Leucyl-tRNA synthetase CY96_22865 ENOG410605W Major Facilitator CY96_22870 ENOG4107S91 Sodium hydrogen exchanger CY96_22875 ENOG4105NCW Trka-c domain protein CY96_22890 ENOG4105C19 ABC transporter CY96_22910 ENOG4105N5T Radical SAM Protein CY96_22930 ENOG4107A6P CY96_22950 ENOG4105E8V Alpha Beta Hydrolase Fold protein CY96_22955 ENOG4108Z0R Transferase CY96_22960 ENOG4105YVM Phosphoesterase, PA-phosphatase related CY96_22965 ENOG4105BZF Glycosyl transferase (Group 1 CY96_22975 ENOG4105EPU Molybdenum cofactor synthesis domain protein CY96_22990 ENOG4108MK9 spermidine N(1)-acetyltransferase CY96_23030 ENOG4105BZU Histidine kinase CY96_23035 ENOG4105BZU Histidine kinase CY96_23040 ENOG4107S9D Alpha beta hydrolase CY96_23045 ENOG4107T7U Sulfatase CY96_23065 ENOG4105D2X ABC transporter substrate-binding protein CY96_23075 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CY96_23130 ENOG41080TC multidrug resistance protein CY96_23135 ENOG410839T multidrug resistance protein CY96_23155 ENOG4108V2W Carbonate dehydratase CY96_23160 ENOG4105C4M (Ubiquinol oxidase) subunit I CY96_23165 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CY96_23200 ENOG41087YS Phage shock protein A CY96_23225 ENOG4105N67 Proton-coupled thiamine transporter YuaJ CY96_23230 ENOG4105BZU Histidine kinase CY96_23235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CY96_23260 ENOG4108UGV hypoxanthine phosphoribosyltransferase CY96_23265 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CY96_23295 ENOG4107ZTW SNARE associated Golgi CY96_23310 ENOG4105C19 ABC transporter CY96_23315 ENOG41086D8 Transcriptional regulator CY96_23325 ENOG4105CJ1 ABC, transporter CY96_23335 ENOG41082BM Transcriptional regulator, arsr family CY96_23375 ENOG4105C6Z Gluconate CY96_23380 ENOG4105FDP GntR family transcriptional regulator CY96_23400 ENOG41069H0 dihydroorotase EC 3.5.2.3 CY96_23420 ENOG4105DTQ mandelate racemase muconate lactonizing CY96_23430 ENOG4108IPT Naphthoate synthase CY96_23435 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CY96_23445 ENOG4105E4F Isochorismate synthase CY96_23455 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CY96_23465 ENOG4105VEQ Cold shock protein CY96_23505 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CY96_23520 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CY96_23615 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CY96_23650 ENOG4105KT7 mgtC SapB transporter CY96_23655 ENOG4107PBV potassium channel CY96_23670 ENOG4105WG9 Conserved Protein CY96_23680 ENOG4105CHM Aminotransferase CY96_23685 ENOG4108ZB6 transcriptional regulator AsnC family CY96_23690 ENOG4105C5I Dehydrogenase CY96_23695 ENOG4108MUZ hydrolase CY96_23705 ENOG4105C87 Aminotransferase class I and II CY96_23720 ENOG4105Y38 Kinase-associated protein B CY96_23730 ENOG4107R3E Citrate transporter CY96_23745 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CY96_23750 ENOG4105KA0 thioesterase Superfamily protein CY96_23765 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CY96_23780 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CY96_23785 ENOG41069ER domain protein CY96_23800 ENOG4105CEP NADH dehydrogenase CY96_23830 ENOG4105EWC Purine nucleoside phosphorylase CY96_23845 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CY96_23865 ENOG4108JJA ABC, transporter CY96_23870 ENOG4105C4B ABC transporter, permease CY96_23875 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CY96_23935 ENOG41083MR nifu domain-containing protein CY96_23950 ENOG4108W5N phosphatidylglycerophosphatase a CY96_23970 ENOG4105DAX Pfam:DUF2983 CY96_23985 ENOG4105DYS nad(p)h dehydrogenase (quinone) CY96_23990 ENOG4105D4U had-superfamily hydrolase, subfamily iia CY96_24005 ENOG4105CBT Fructose-1,6-bisphosphatase CY96_24020 ENOG4105MMD transcriptional regulator CY96_24025 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CY96_24030 ENOG4107TXC Transcriptional regulator CY96_24035 ENOG41090T1 Membrane CY96_24060 ENOG4105FAA peptidase M23 CY96_24065 ENOG4108YTE sporulation protein YunB CY96_24070 ENOG4105KZD Domain of unknown function (DUF1805) CY96_24075 ENOG4107R8B 5'-nucleotidase CY96_24080 ENOG4105DIW FeS assembly protein SUFB CY96_24085 ENOG4108UNV SUF system FeS assembly protein, NifU family CY96_24090 ENOG4105C9B Cysteine desulfurase CY96_24095 ENOG4105JRK feS assembly protein SufD CY96_24100 ENOG4105C3K feS assembly ATPase SufC CY96_24105 ENOG4105D01 (LipO)protein CY96_24110 ENOG4108UMI ABC transporter, permease CY96_24115 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CY96_24140 ENOG41080E8 Transcriptional regulator, Spx MgsR family CY96_24160 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CY96_24185 ENOG4108W8B Beta-lactamase domain protein CY96_24190 ENOG4105C1G acyl-Coa dehydrogenase CY96_24195 ENOG4105CHU acetyl-coa acetyltransferase CY96_24210 ENOG4105DZ1 carboxypeptidase CY96_24230 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CY96_24245 ENOG4108SUT Major Facilitator Superfamily CY96_24250 ENOG4107R7I amino acid CY96_24265 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CY96_24275 ENOG4107AYK membrAne CY96_24310 ENOG4107ZTW SNARE associated Golgi CY96_24320 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CY96_24325 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CY96_24330 ENOG4105BZU Histidine kinase CY96_24345 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CY96_24360 ENOG4105C8Q Methyl-accepting chemotaxis CY96_24365 ENOG4105VG1 fes assembly suf system protein CY96_24370 ENOG4105D4Y metalloprotease CY96_24390 ENOG4107T5V SNARE associated Golgi CY96_24395 ENOG4107S91 Sodium hydrogen exchanger CY96_24400 ENOG4105NCW Trka-c domain protein CY96_24430 ENOG4108URH decarboxylase CY96_24440 ENOG41090A1 ferritin CY96_24445 ENOG4105DHF Membrane CY96_24450 ENOG4105D9N nucleoside CY96_24455 ENOG4105D9N nucleoside CY96_24470 ENOG4108RYK Nad-dependent epimerase dehydratase CY96_24490 ENOG4105CV8 reductase CY96_24495 ENOG4105F27 Major Facilitator CY96_24500 ENOG4105KVH Transcriptional regulator CY96_24515 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CY96_24520 ENOG4105D4A Cell wall formation (By similarity) CY96_24530 ENOG4105C8Q Methyl-accepting chemotaxis CY96_24540 ENOG4105WMR Protein CrcB homolog CY96_24545 ENOG4105WMR Protein CrcB homolog CY96_24565 ENOG4105C5H ABC transporter CY96_24570 ENOG4108MK9 spermidine N(1)-acetyltransferase CY96_24575 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CY96_24600 ENOG4108IPW abc transporter atp-binding protein CY96_24605 ENOG4105CM4 permease protein CY96_24620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CY96_24640 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CY96_24650 ENOG4105XZU Preprotein translocase, subunit SecG CY96_24655 ENOG41067MG lrgb family CY96_24705 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CY96_24715 ENOG4105RHA ABC transporter, permease CY96_24720 ENOG4108IUX (ABC) transporter CY96_24725 ENOG4105BZU Histidine kinase CY96_24730 ENOG4108W5X Transcriptional Regulator, LuxR family CY96_24750 ENOG41090VF Stage v sporulation protein ac CY96_24755 ENOG4105CZ3 stage V sporulation protein ad CY96_24770 ENOG4108QY0 Membrane CY96_24775 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CY96_24790 ENOG4105KRI phosphocarrier protein (HPr CY96_24800 ENOG4105CHW UPF0052 protein CY96_24805 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CY96_24810 ENOG4108Z4K mutator MutT protein CY96_24820 ENOG4105C3M thioredoxin reductase CY96_24830 ENOG4108S4C acetyltransferase CY96_24850 ENOG41086DT Membrane protein of unknown function CY96_24860 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CY96_24865 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CY96_24880 ENOG4107TXC Transcriptional regulator CY96_24900 ENOG4105DUM transcriptional regulator, lysR family CY96_24910 ENOG4108WS4 fmn reductase CY96_24925 ENOG4105BZ1 (ABC) transporter CY96_24935 ENOG4105CN1 protease CY96_24940 ENOG4105CRP Part of the ABC transporter FtsEX involved in CY96_24945 ENOG4105CAK Cell division ATP-binding protein ftsE CY96_24955 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CY96_24975 ENOG4108RDQ ABC transporter CY96_25005 ENOG4105MS2 ribosomal subunit Interface protein CY96_25010 ENOG4105VEQ Cold shock protein CY96_25015 ENOG41081UC Inherit from COG: Competence protein CY96_25030 ENOG4105KVH Transcriptional regulator CY96_25040 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CY96_25045 ENOG4108KGH TRANSCRIPTIONal CY96_25050 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CY96_25055 ENOG4105C6Y Udp-glucose 6-dehydrogenase CY96_25060 ENOG4105ESV Glycosyl transferase, family 4 CY96_25070 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CY96_25090 ENOG4105F8D glycoside hydrolase family 4 CY96_25095 ENOG4105VCP PTS System CY96_25100 ENOG4105CK1 PTS System CY96_25110 ENOG4105VCP PTS System CY96_25120 ENOG4105VZJ PTS System CY96_25140 ENOG4105ECB domain protein CY96_25145 ENOG4107RSM transcriptional regulator CY96_25180 ENOG4105DAA L-lactate CY96_25190 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) CY96_25200 ENOG4105E0M Sulfatase CY96_25240 ENOG4107R8N Glycosyl transferase, family 2 CY96_25250 ENOG4105C94 Transporter CY96_25255 ENOG41069ER domain protein CY96_25280 ENOG4105KBK Zinc finger, swim domain protein CY96_25285 ENOG4105C0D helicase CY96_25315 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CY96_25325 ENOG4107RBB ABC transporter, permease CY96_25330 ENOG4105C19 ABC transporter CY96_25350 ENOG4105CXY transporter CY96_25365 ENOG4105BZU Histidine kinase CY96_25370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CY96_25375 ENOG4105DG6 mannose-6-phosphate isomerase CY96_25380 ENOG4105DM4 PTS System CY96_25400 ENOG4108KGH TRANSCRIPTIONal CY96_25405 ENOG4105DG6 mannose-6-phosphate isomerase CY96_25410 ENOG4105CJT Mannose-1-phosphate guanylyltransferase CY96_25420 ENOG4108TJN glycosyl transferase group 1 CY96_25425 ENOG4105C6Y Udp-glucose 6-dehydrogenase CY96_25455 ENOG4105D3Q Sugar transferase CY96_25460 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CY96_25465 ENOG4108RB3 Capsular polysaccharide biosynthesis protein CY96_25470 ENOG4107YJ4 chain length determinant protein CY96_25475 ENOG4105HTX biosynthesis protein CY96_25480 ENOG4107YJ4 chain length determinant protein CY96_25495 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CY96_25505 ENOG4105FRN stage II sporulation protein CY96_25520 ENOG4105DY9 regulatoR CY96_25550 ENOG4106778 Protein of unknown function (DUF1146) CY96_25555 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CY96_25560 ENOG4105C8S subunit m CY96_25565 ENOG4105D65 subunit l CY96_25590 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CY96_25595 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CY96_25605 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CY96_25610 ENOG4105BZU Histidine kinase CY96_25665 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) CY96_25670 ENOG41062M3 atp synthase CY96_25690 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CY96_25695 ENOG4108UIC UPF0340 protein CY96_25700 ENOG4108YZG isomerase CY96_25715 ENOG4108VGI doxx family CY96_25720 ENOG4107XC4 flavin reductase domain protein, FMN-binding CY96_25740 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CY96_25750 ENOG4108ZXQ stage ii sporulation protein r CY96_25755 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CY96_25760 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CY96_25765 ENOG4107104 thymidine kinase CY96_25775 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CY96_25790 ENOG4105CBT Fructose-1,6-bisphosphatase CY96_25800 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CY96_25820 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CY96_25835 ENOG4105C1G acyl-Coa dehydrogenase CY96_25840 ENOG4105C1G acyl-Coa dehydrogenase CY96_25845 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CY96_25855 ENOG4105DF6 Fe-S oxidoreductase CY96_25870 ENOG4105BZU Histidine kinase CY96_25885 ENOG4105D4Y metalloprotease CY96_25895 ENOG4105BZU Histidine kinase CY96_25900 ENOG4105KCT ABC transporter CY96_25905 ENOG4108M15 ABC transporter CY96_25910 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) CY96_25920 ENOG4105IIU Aminopeptidase CY96_25940 ENOG4105EMN RNA polymerase sigma factor CY96_25950 ENOG410684U Domain of unknown function (DUF1934) CY96_25970 ENOG4105CYW agmatinase CY96_25980 ENOG4105DXB Major Facilitator superfamily CY96_25985 ENOG4107SWG transcriptional regulator MERR family CY96_25995 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CY96_26000 ENOG4105BZ4 penicillin-binding protein CY96_26005 ENOG4108XFG YwhD family CY96_26010 ENOG4108Z4T Peptidase M50 CY96_26015 ENOG41069HH 4-oxalocrotonate tautomerase CY96_26020 ENOG4105DCI Phosphohydrolase CY96_26025 ENOG4108MES Periplasmic binding protein CY96_26030 ENOG4105E0A ABC, transporter CY96_26035 ENOG4105EHG Permease protein CY96_26040 ENOG4105DQ5 transport system permease protein CY96_26050 ENOG4108VCI transcription factor, rsfa family CY96_26055 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CY96_26060 ENOG4108IJ2 phosphate acetyltransferase CY96_26065 ENOG4107UEZ chlorite dismutase CY96_26075 ENOG4108VKI Cell wall hydrolase CY96_26095 ENOG4107SVH Potassium channel protein CY96_26105 ENOG410667J hydrolase CY96_26110 ENOG4105VCH membrane CY96_26120 ENOG4108TU7 Inherit from COG: (ABC) transporter CY96_26125 ENOG4105CJ1 ABC, transporter CY96_26130 ENOG41090WU lipolytic protein G-D-S-L family CY96_26145 ENOG4105D6E homoserine dehydrogenase CY96_26170 ENOG4108Y4K DNA-binding transcriptional activator CY96_26180 ENOG4105WH1 Two component transcriptional regulator luxr family CY96_26185 ENOG4105BZU Histidine kinase CY96_26190 ENOG4105DWF phosphomethylpyrimidine kinase CY96_26195 ENOG4105BZU Histidine kinase CY96_26200 ENOG4105VCD cytoplasmic protein CY96_26205 ENOG4105D22 carbon starvation protein CY96_26210 ENOG4105DY9 regulatoR CY96_26215 ENOG41079KZ Major Facilitator Superfamily CY96_26225 ENOG4105CG5 Glycosyl transferase (Group 1 CY96_26235 ENOG4105EN6 Membrane CY96_26240 ENOG4106YBV Methyl-accepting chemotaxis CY96_26250 ENOG4108S4H thioesterase Superfamily protein CY96_26255 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) CY96_26270 ENOG4105K64 Glycosyl transferase, family 2 CY96_26280 ENOG4105EJV Membrane CY96_26285 ENOG4105CKK Glycosyl transferase, family 2 CY96_26290 ENOG4105C5H ABC transporter CY96_26295 ENOG41067SE Tetr family transcriptional regulator CY96_26305 ENOG4105E0X reductase CY96_26310 ENOG4106F5Q Membrane CY96_26325 ENOG4108NEV two component transcriptional regulator, LytTR family CY96_26330 ENOG4108HRK Histidine kinase CY96_26335 ENOG4107RGD Major Facilitator superfamily CY96_26350 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CY96_26360 ENOG4105IW1 AmiS UreI transporter CY96_26365 ENOG4105CMR udp-glucose 4-epimerase CY96_26370 ENOG4108UT2 hemolysin iii CY96_26380 ENOG4105C1J atp-dependent rna helicase CY96_26385 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) CY96_26410 ENOG4105BZU Histidine kinase CY96_26425 ENOG4105C0H protease CY96_26430 ENOG4105Q2H domain protein CY96_26445 ENOG4105BZU Histidine kinase CY96_26450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CY96_26475 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CY96_26480 ENOG4105CDU Replicative dna helicase CY96_26490 ENOG4105BZR domain protein CY96_26495 ENOG4108XMW Membrane CY96_26505 ENOG4108UUM single-stranded DNA-binding protein CY96_26515 ENOG4105C3G gtp-binding protein CY96_26520 ENOG4105VDK protein, conserved in bacteria CY96_26525 ENOG4105D8X mechanosensitive ion channel CY96_26530 ENOG4108ZDA Sporulation protein YyaC CY96_26535 ENOG4105FA0 parb-like partition protein CY96_26540 ENOG4107QJE Chromosome Partitioning Protein CY96_26555 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CY96_26560 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CY96_26570 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CY96_26590 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CY96_26595 ENOG410848D S4 domain protein YaaA CY96_26610 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CY96_26635 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CY96_26670 ENOG4105ZMH deoxynucleoside kinase CY96_26680 ENOG4105GTG Isochorismatase CY96_26685 ENOG4108Z6B deaminase CY96_26690 ENOG4105C6E dna polymerase iii CY96_26710 ENOG41067KS pro-sigma K processing CY96_26735 ENOG4105CXN decarboxylase CY96_26745 ENOG4105FA2 dna polymerase iii CY96_26750 ENOG4105MA4 psp1 domain protein CY96_26760 ENOG41060K3 Methyltransferase CY96_26770 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CY96_26775 ENOG4105KRN Transcriptional regulator, abrb family CY96_26780 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CY96_26785 ENOG4105F8V Hydrolase, tatD family CY96_26790 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) CY96_26800 ENOG4105XFA sporulation peptidase YabG CY96_26805 ENOG4105W42 Veg protein CY96_26820 ENOG4105DFT pur operon repressor CY96_26825 ENOG4105KME endoribonuclease L-psp CY96_26840 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CY96_26845 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CY96_26855 ENOG4108JA2 transcriptioN-repair coupling factor CY96_26860 ENOG4108M14 stage v sporulation protein t CY96_26870 ENOG4108IY2 MazG family CY96_26875 ENOG41082I2 s4 domain protein CY96_26880 ENOG4105VYY sporulation protein yabp CY96_26895 ENOG41060GV RNA binding s1 domain protein CY96_26915 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CY96_26920 ENOG4108UGV hypoxanthine phosphoribosyltransferase CY96_26925 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CY96_26940 ENOG4105C6T cysteine synthase CY96_26945 ENOG4105CRQ synthase (Component I) CY96_26950 ENOG4105DDQ anthranilate synthase CY96_26955 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CY96_26960 ENOG4105EEI dihydropteroate synthase CY96_26965 ENOG4105KRF dihydroneopterin aldolase CY96_26970 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CY96_26980 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CY96_27010 ENOG4108Z0C Uvrb UvrC protein CY96_27025 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CY96_27035 ENOG4105CTP PilT protein domain protein CY96_27040 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CY96_27055 ENOG4105D7W serine acetyltransferase CY96_27070 ENOG4105C2N RNA methyltransferase TrmH family group 3 CY96_27075 ENOG4105M0M Tetracycline resistance protein CY96_27080 ENOG4105QIV RNA polymerase CY96_27090 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CY96_27115 ENOG4107Y49 methyltransferase CY96_27130 ENOG4105XPM ribosomal protein CY96_27235 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CY96_27260 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CY96_27270 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CY96_27280 ENOG41067V7 50S ribosomal protein L36 CY96_27305 ENOG4108JJB ABC transporter CY96_27310 ENOG4108JJB ABC transporter CY96_27315 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CY96_27320 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CY96_27345 ENOG4105D1F ATP-binding protein CY96_27360 ENOG4108NMV polysaccharide deacetylase CY96_27495 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CY96_27505 ENOG4105K70 DNA-binding protein CY96_27510 ENOG4105D9U N-acetyltransferase CY96_27515 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein CY96_27530 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CY96_27540 ENOG4108XG2 Histidine kinase CY96_27555 ENOG41067SE Tetr family transcriptional regulator CY96_27590 ENOG4105CAQ asparagine synthetase CY96_27595 ENOG4108RZE Tetr family transcriptional regulator CY96_27615 ENOG4108IBT Inherit from COG: transposase CY96_27675 ENOG4107U9B transcriptional regulator CY96_27680 ENOG4108UMN azlc family CY96_27685 ENOG4105KMT branched-chain amino acid CY96_27715 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) CY96_27720 ENOG4108V2W Carbonate dehydratase CY96_27755 ENOG4108WZA zeta toxin CY96_27760 ENOG4105M6F mutator MutT protein CY96_27765 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CY96_27900 ENOG4105F27 Major Facilitator CY96_27910 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CY96_27930 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CY96_27935 ENOG4105C8Y Acetylornithine aminotransferase CY96_27945 ENOG4105D49 3-dehydroquinate synthase CY96_27950 ENOG4105W06 Cupin 2, conserved barrel domain protein CY96_27955 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CY96_27960 ENOG4105E98 transcriptional regulator DeoR family CY96_27965 ENOG4107XGZ Hydrolase CY96_28065 ENOG4105CNU cell division protein FtsK CY96_28200 ENOG4105D7V transposase CY96_28355 ENOG4105DHF Membrane CY96_28365 ENOG4105KRN Transcriptional regulator, abrb family CY96_28375 ENOG4105D7V transposase CY96_28395 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CY96_28425 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CY96_28460 ENOG4105D7V transposase CY96_28475 ENOG4108MK9 spermidine N(1)-acetyltransferase CY96_28490 ENOG4108KS4 Spore coat protein CY96_28495 ENOG4107SBE Glycosyl transferase (Group 1 CY96_28515 ENOG4107SBE Glycosyl transferase (Group 1 CY96_28520 ENOG4108IAJ Nad-dependent epimerase dehydratase CY96_28560 ENOG4105KRN Transcriptional regulator, abrb family CY96_28625 ENOG4105CVK Glutamate decarboxylase CY96_28690 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CY96_28695 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CY96_28705 ENOG4105NA0 Transcriptional regulator CY96_28715 ENOG4105D7V transposase CY96_28730 ENOG4105D7V transposase CY96_28740 ENOG4105CHR reductase CY96_28820 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CY96_28830 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CY96_28855 ENOG4105D7V transposase CY96_28905 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CY96_28930 ENOG410625E CY96_28935 ENOG4106A3M Cytochrome p-450 CY96_28960 ENOG4105IYK transposase CY96_28965 ENOG4105DQ6 Transposase CY96_28970 ENOG4105BZ4 penicillin-binding protein CY96_28975 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CY96_29010 ENOG4105MZU cell filamentation protein CY96_29015 ENOG4105C44 Serine transporter CY96_29050 ENOG4105F6S Spore photoproduct lyase CY96_29070 ENOG4107QHE Choloylglycine hydrolase CY96_29090 ENOG4105DQ6 Transposase CY96_29105 ENOG4105DRR Transcriptional regulator, GntR family CY96_29120 ENOG4108SQ9 flavin reductase domain protein, FMN-binding CY96_29135 ENOG4108QY0 Membrane CY96_29150 ENOG4108NHD germination protein CY96_29155 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CY96_29160 ENOG4108ZJ4 polysaccharide deacetylase CY96_29185 ENOG4108NGU Transcriptional regulator CY96_29225 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CY96_29240 ENOG4105BZC d-serine deaminase CY96_29245 ENOG4105CZV ABC transporter CY96_29285 ENOG4105CEY Amp-dependent synthetase and ligase CY96_29310 ENOG4107Y80 Major Facilitator superfamily CY96_29345 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C CY96_29350 ENOG4108M1A Chitin-binding protein CY96_29360 ENOG4105E1K spore germination protein CY96_29465 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CY96_29515 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CY96_29550 ENOG4105BZ1 (ABC) transporter CY96_29570 ENOG41067FT ParB-like nuclease domain CY96_29620 ENOG4105IBP Cyclic peptide transporter CY96_29625 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CY96_29630 ENOG4105C0W non-ribosomal peptide synthetase CY96_29645 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) CY96_29650 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CY96_29665 ENOG4105C1G acyl-Coa dehydrogenase CY96_29685 ENOG4105C0W non-ribosomal peptide synthetase CY96_29685 ENOG4105C0W non-ribosomal peptide synthetase CY96_29695 ENOG4105DY9 regulatoR CY96_29740 ENOG4107SET aldo keto reductase CY96_29905 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)