locus-tag class description DTO10_00030 ENOG41068JE domain protein DTO10_00065 ENOG4105EP9 oxidoreductase DTO10_00085 ENOG4105DUM transcriptional regulator, lysR family DTO10_00090 ENOG4105HMI Membrane DTO10_00095 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DTO10_00100 ENOG4105R40 Glycine betaine carnitine choline DTO10_00105 ENOG4108HQR Glycine betaine DTO10_00110 ENOG4105E90 ABC transporter DTO10_00115 ENOG4108IJ8 ABC transporter DTO10_00120 ENOG4105C1G acyl-Coa dehydrogenase DTO10_00125 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase DTO10_00130 ENOG4105DQ6 Transposase DTO10_00140 ENOG4105D0M Protease HtpX homolog DTO10_00160 ENOG4105K4T epimerase DTO10_00165 ENOG4107TB6 phosphoglycerate mutase DTO10_00175 ENOG4108U5N UPF0316 protein DTO10_00185 ENOG4105CGK Exodeoxyribonuclease III DTO10_00190 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DTO10_00195 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) DTO10_00205 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DTO10_00210 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) DTO10_00230 ENOG4108VCA G U mismatch-specific DNA glycosylase DTO10_00235 ENOG4105C87 Aminotransferase class I and II DTO10_00240 ENOG4105K4H Nlp p60 protein DTO10_00255 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_00260 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR DTO10_00265 ENOG410635A Membrane DTO10_00270 ENOG4108Z73 Siroheme synthase DTO10_00275 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DTO10_00280 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DTO10_00290 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DTO10_00295 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DTO10_00300 ENOG4107RIQ Sulfate adenylate transferase DTO10_00305 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) DTO10_00315 ENOG4108UZX fmn reductase DTO10_00330 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) DTO10_00335 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) DTO10_00340 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DTO10_00350 ENOG4105CRQ synthase (Component I) DTO10_00355 ENOG4105DEN Luciferase family DTO10_00360 ENOG4105DEN Luciferase family DTO10_00370 ENOG4105DPN Oligoendopeptidase f DTO10_00395 ENOG4105WH1 Two component transcriptional regulator luxr family DTO10_00405 ENOG4105CM2 brancheD-chain amino acid aminotransferase DTO10_00410 ENOG4105FCD Major Facilitator DTO10_00415 ENOG4105TMB Formate nitrite transporter DTO10_00420 ENOG4105C02 permease DTO10_00430 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DTO10_00450 ENOG4105DRP amino acid AbC transporter DTO10_00455 ENOG4105EAD ABC transporter DTO10_00460 ENOG4105CT1 (ABC) transporter DTO10_00465 ENOG4105CDA abc transporter atp-binding protein DTO10_00475 ENOG4108QY0 Membrane DTO10_00485 ENOG4107TT2 Auxin Efflux Carrier DTO10_00490 ENOG4107Y2X deaminase DTO10_00500 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DTO10_00505 ENOG4105RWS endonuclease I DTO10_00510 ENOG4105P8F nudix hydrolase DTO10_00515 ENOG4105CGH 5'-nucleotidase DTO10_00525 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DTO10_00530 ENOG4105C26 Dehydrogenase DTO10_00540 ENOG4105C5I Dehydrogenase DTO10_00550 ENOG4108UKI Enoyl-CoA hydratase DTO10_00555 ENOG4108JQ7 (ABC) transporter DTO10_00565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DTO10_00570 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DTO10_00575 ENOG4108J59 Extracellular solute-binding protein, family 5 DTO10_00600 ENOG4107S1V Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DTO10_00605 ENOG4105ECB domain protein DTO10_00620 ENOG41076HS cation diffusion facilitator family transporter DTO10_00630 ENOG4105C85 amino acid DTO10_00635 ENOG4108JPW Aminotransferase DTO10_00645 ENOG4105BZU Histidine kinase DTO10_00655 ENOG4105C26 Dehydrogenase DTO10_00660 ENOG4108W2Y isochorismatase DTO10_00670 ENOG4108ZCF integral membrane protein DTO10_00675 ENOG4107QZW Altronate oxidoreductase DTO10_00680 ENOG4105CPQ Dehydrogenase DTO10_00685 ENOG4105CTX dehydratase DTO10_00690 ENOG4108W3Q Transcriptional regulator DTO10_00695 ENOG4108I5G Major Facilitator superfamily DTO10_00705 ENOG4105DMW Dehydrogenase reductase DTO10_00715 ENOG4105CPQ Dehydrogenase DTO10_00720 ENOG4105DG4 malate L-lactate dehydrogenase DTO10_00735 ENOG4105CHR reductase DTO10_00740 ENOG4105C8M UPF0272 protein DTO10_00745 ENOG4105C8M UPF0272 protein DTO10_00750 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase DTO10_00765 ENOG4105D7K pfkb domain protein DTO10_00770 ENOG4105ERH Fumarylacetoacetate hydrolase DTO10_00785 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DTO10_00790 ENOG4105CXK mandelate racemase muconate lactonizing DTO10_00795 ENOG4105C26 Dehydrogenase DTO10_00800 ENOG4105CTX dehydratase DTO10_00815 ENOG4107HP6 Transcriptional regulator DTO10_00820 ENOG4105C01 Dihydroxy-acid dehydratase DTO10_00830 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DTO10_00835 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DTO10_00840 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter DTO10_00845 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit DTO10_00855 ENOG4105BZ1 (ABC) transporter DTO10_00870 ENOG4105VRS hydrolase family 18 DTO10_00875 ENOG410904N short-chain dehydrogenase reductase DTO10_00880 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DTO10_00885 ENOG4105XTG Pfam:DUF156 DTO10_00895 ENOG4107XWI flavin reductase domain protein, FMN-binding DTO10_00900 ENOG4105FBA Phospholipase Carboxylesterase DTO10_00905 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DTO10_00925 ENOG4105CHR reductase DTO10_00930 ENOG4108X3M OsmC Ohr family protein DTO10_00935 ENOG4106AUC UPF0180 protein DTO10_00965 ENOG4105KVH Transcriptional regulator DTO10_00985 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DTO10_00990 ENOG41080XQ Signal transduction protein with cbs domains DTO10_00995 ENOG4108TU7 Inherit from COG: (ABC) transporter DTO10_01000 ENOG4105CJ1 ABC, transporter DTO10_01010 ENOG4105D8G Major Facilitator superfamily DTO10_01015 ENOG4105BZU Histidine kinase DTO10_01020 ENOG4108JYZ YitT family DTO10_01035 ENOG4105C9U ATP-dependent DNA helicase RecQ DTO10_01040 ENOG41069ER domain protein DTO10_01055 ENOG4105WEF catalase DTO10_01060 ENOG4105QNR S1 RNA binding domain protein DTO10_01065 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DTO10_01080 ENOG4105VRR gCN5-related N-acetyltransferase DTO10_01085 ENOG4105EEM helicase DTO10_01090 ENOG4105C5H ABC transporter DTO10_01100 ENOG4105CSH Transporter DTO10_01105 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_01110 ENOG4108IG5 Transcriptional regulator DTO10_01115 ENOG4105DZ6 Band 7 protein DTO10_01125 ENOG4105VKD bioY protein DTO10_01135 ENOG4108UT2 hemolysin iii DTO10_01140 ENOG4105F0V Cell wall hydrolase DTO10_01150 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme DTO10_01160 ENOG4105DM4 PTS System DTO10_01165 ENOG4105DE4 1-phosphofructokinase DTO10_01170 ENOG4105E98 transcriptional regulator DeoR family DTO10_01175 ENOG4105C7S Dehydrogenase DTO10_01180 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DTO10_01185 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DTO10_01205 ENOG4108RPX mosc domain containing protein DTO10_01210 ENOG4105FDF Could be involved in DNA repair (By similarity) DTO10_01215 ENOG4105DQE DNA ligase DTO10_01230 ENOG4108V2W Carbonate dehydratase DTO10_01245 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DTO10_01260 ENOG41067MG lrgb family DTO10_01285 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DTO10_01290 ENOG4105D64 Mechanosensitive ion channel DTO10_01295 ENOG4107QMU Mate efflux family protein DTO10_01310 ENOG4105K4I Scp-like extracellular DTO10_01325 ENOG4105BZU Histidine kinase DTO10_01330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DTO10_01350 ENOG4105CKI cobalamin synthesis protein DTO10_01355 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) DTO10_01360 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DTO10_01365 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) DTO10_01370 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate DTO10_01380 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) DTO10_01385 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DTO10_01400 ENOG4105D3A purine nucleoside phosphorylase DeoD-type DTO10_01415 ENOG4105BZU Histidine kinase DTO10_01420 ENOG4105VSD UPF0346 protein DTO10_01425 ENOG41060D1 Quinol oxidase DTO10_01440 ENOG4105E2S oxidase) subunit II DTO10_01450 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DTO10_01455 ENOG4108JUB Transcriptional regulator DTO10_01460 ENOG4108TSC N-acetyltransferase DTO10_01465 ENOG4107S4Y M20 DapE family protein YgeY DTO10_01480 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DTO10_01505 ENOG4105E0X reductase DTO10_01510 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DTO10_01525 ENOG41090WU lipolytic protein G-D-S-L family DTO10_01530 ENOG4108KF3 Electron transport protein SCO1 SenC DTO10_01545 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DTO10_01550 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DTO10_01555 ENOG4105C7B Threonine dehydratase DTO10_01560 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) DTO10_01565 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DTO10_01580 ENOG4107TS3 membrane protein, TerC DTO10_01590 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DTO10_01595 ENOG4107YX5 Pfam:DUF548 DTO10_01600 ENOG4108Y6J UPF0403 protein DTO10_01605 ENOG4105C01 Dihydroxy-acid dehydratase DTO10_01615 ENOG4105C5H ABC transporter DTO10_01625 ENOG4105EPR degv family DTO10_01630 ENOG4108V06 Glutathione peroxidase DTO10_01640 ENOG4105CVG Homoserine O-transsuccinylase DTO10_01650 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DTO10_01655 ENOG4105KST dependent repressor DTO10_01710 ENOG4108VXD carboxy-peptidase DTO10_01715 ENOG4107STQ Multicopper oxidase DTO10_01760 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) DTO10_01805 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) DTO10_01810 ENOG4105NX3 Membrane DTO10_01815 ENOG4105VMP Transcriptional regulator DTO10_01835 ENOG4105JZI cytochrome P450 DTO10_01845 ENOG4107SNB ankyrin repeat protein YahD DTO10_01850 ENOG4108Z6B deaminase DTO10_01855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DTO10_01860 ENOG4105BZU Histidine kinase DTO10_01900 ENOG4105ECB domain protein DTO10_01930 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DTO10_01945 ENOG4105DHT Metal Dependent Phosphohydrolase DTO10_01960 ENOG41081VK Ribonuclease DTO10_01980 ENOG4105KHC sulfurtransferase DTO10_01990 ENOG410890F Dynamin family DTO10_02000 ENOG41065KQ synthase DTO10_02005 ENOG4105C2W permease DTO10_02010 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) DTO10_02020 ENOG4105NAA Cytochrome C oxidase, subunit II DTO10_02025 ENOG4107RQ2 Cytochrome c oxidase, subunit I DTO10_02030 ENOG4105CTD carboxy-peptidase DTO10_02035 ENOG4105DVT helicase DTO10_02045 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DTO10_02050 ENOG4105BZU Histidine kinase DTO10_02060 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) DTO10_02065 ENOG4108UKS UPF0398 protein DTO10_02075 ENOG4107X2U Inherit from COG: Exonuclease-like protein DTO10_02080 ENOG4108I5C dEAD DEAH box helicase DTO10_02085 ENOG4108MUZ hydrolase DTO10_02120 ENOG4105BZ4 penicillin-binding protein DTO10_02130 ENOG4105CSM endonuclease III DTO10_02140 ENOG4105C5S asparaginyl-tRNA synthetase DTO10_02145 ENOG4105CHM Aminotransferase DTO10_02155 ENOG4105YAC DTO10_02160 ENOG4105DVT helicase DTO10_02165 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) DTO10_02175 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DTO10_02185 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate DTO10_02190 ENOG4105CPK Glycosyl transferase (Group 1 DTO10_02195 ENOG4105FJR Lmbe family DTO10_02200 ENOG4108Z5K methylglyoxal synthase DTO10_02205 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DTO10_02210 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DTO10_02215 ENOG4108JYZ YitT family DTO10_02235 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit DTO10_02240 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DTO10_02245 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) DTO10_02260 ENOG41068YB TPR repeat-containing protein DTO10_02270 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DTO10_02280 ENOG4105CIH Imidazole acetol-phosphate transaminase DTO10_02285 ENOG4105KHN chorismate mutase DTO10_02290 ENOG4105D49 3-dehydroquinate synthase DTO10_02295 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DTO10_02300 ENOG4105BZU Histidine kinase DTO10_02305 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DTO10_02310 ENOG4105EAH synthase DTO10_02315 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DTO10_02320 ENOG4105XXQ heptaprenyl diphosphate synthase component I DTO10_02330 ENOG4105EUJ GTP cyclohydrolase i DTO10_02335 ENOG4105K70 DNA-binding protein DTO10_02340 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DTO10_02355 ENOG4105C8Y Acetylornithine aminotransferase DTO10_02360 ENOG4108JUB Transcriptional regulator DTO10_02365 ENOG4105CUB amino acid DTO10_02370 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DTO10_02390 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) DTO10_02395 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DTO10_02400 ENOG4105E9Q Acyl-transferase DTO10_02405 ENOG4105CAT Cytidine monophosphate kinase DTO10_02420 ENOG4105MSI germination protein ypeb DTO10_02425 ENOG4105F0V Cell wall hydrolase DTO10_02435 ENOG4105HDK L-asparaginase DTO10_02440 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DTO10_02460 ENOG4107RGJ metallophosphoesterase DTO10_02475 ENOG4105I7S Abortive infection protein DTO10_02480 ENOG4105C9U ATP-dependent DNA helicase RecQ DTO10_02485 ENOG4105T7X DTO10_02495 ENOG4108SAX Membrane DTO10_02500 ENOG4108JQ1 Dehydrogenase DTO10_02515 ENOG4105BZU Histidine kinase DTO10_02520 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DTO10_02525 ENOG4105CRE cytochrome C DTO10_02530 ENOG4107TWT Cytochrome c biogenesis protein DTO10_02535 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DTO10_02540 ENOG4105FE9 pseudouridine synthase DTO10_02550 ENOG4108JIC nucleoside recognition domain protein DTO10_02555 ENOG4105DZ1 carboxypeptidase DTO10_02565 ENOG4105D3R alkyl hydroperoxide reductase DTO10_02570 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DTO10_02585 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DTO10_02590 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DTO10_02610 ENOG4105PTM secreted protein DTO10_02625 ENOG4105G6R Stage v sporulation protein ae DTO10_02640 ENOG4105C7N Xanthine uracil vitamin C permease DTO10_02645 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DTO10_02650 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DTO10_02655 ENOG41082AN stage II sporulation protein DTO10_02660 ENOG4105DZ1 carboxypeptidase DTO10_02680 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DTO10_02690 ENOG4105I3K Ferric uptake regulator, Fur family DTO10_02695 ENOG4105MZ9 stage II sporulation protein m DTO10_02720 ENOG4105CPC Aldo Keto reductase DTO10_02730 ENOG4105K56 Transcriptional regulator DTO10_02745 ENOG4106HZJ DTO10_02760 ENOG4105ST3 Transcriptional regulator DTO10_02770 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DTO10_02785 ENOG4108IXY short-chain dehydrogenase reductase DTO10_02790 ENOG41069FQ Metallo-beta-lactamase superfamily DTO10_02795 ENOG4105II7 pyrroline-5-carboxylate reductase DTO10_02830 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DTO10_02835 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DTO10_02840 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DTO10_02845 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DTO10_02850 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DTO10_02855 ENOG4108HNZ carboxyl transferase DTO10_02860 ENOG4108ZVT methylmalonyl-coA epimerase DTO10_02865 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DTO10_02870 ENOG4108QEG Membrane DTO10_02875 ENOG4105CDA abc transporter atp-binding protein DTO10_02880 ENOG4105E5Q amino acid AbC transporter DTO10_02885 ENOG4108HW3 (ABC) transporter DTO10_02890 ENOG4108Y6J UPF0403 protein DTO10_02900 ENOG4105D5P Methylmalonyl-coA mutase DTO10_02910 ENOG4105C7S Dehydrogenase DTO10_02915 ENOG4105CPP Dehydrogenase, E1 component DTO10_02930 ENOG4107RDP Dehydrogenase DTO10_02935 ENOG4108JUB Transcriptional regulator DTO10_02940 ENOG4106CCJ Protein of unknown function (DUF2627) DTO10_02945 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DTO10_02955 ENOG4107QQR Sporulation DTO10_02960 ENOG4105S1Z Stage IV sporulation protein B DTO10_02965 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DTO10_02970 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) DTO10_02975 ENOG4105DX0 Hemolysin A DTO10_02980 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DTO10_02990 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DTO10_02995 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DTO10_03000 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DTO10_03005 ENOG4105M7K Involved in the transcription termination process (By similarity) DTO10_03010 ENOG4108ZSR alkaline shock protein DTO10_03015 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DTO10_03035 ENOG410644B Stage III sporulation protein af DTO10_03045 ENOG4105KQ4 Stage iii sporulation protein ad DTO10_03050 ENOG4108CQH stage III sporulation protein AC DTO10_03055 ENOG4105KR5 Stage iii sporulation protein DTO10_03060 ENOG4105CD2 stage iii sporulation protein aa DTO10_03065 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DTO10_03070 ENOG4105DC7 peptidase M24 DTO10_03085 ENOG4105CBJ Metal-dependent enzyme DTO10_03115 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DTO10_03120 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) DTO10_03125 ENOG4105WZW rhodanese family DTO10_03140 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DTO10_03145 ENOG4105C0D helicase DTO10_03180 ENOG4106855 Competence protein DTO10_03220 ENOG4105C5X domain protein DTO10_03240 ENOG4105E0M Sulfatase DTO10_03260 ENOG4107ZXI Rhomboid family DTO10_03275 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DTO10_03280 ENOG4105WDJ 50S ribosomal protein L33 DTO10_03300 ENOG4108UTW Plays a role in the regulation of phosphate uptake DTO10_03305 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DTO10_03310 ENOG4105E2Z phosphate ABC transporter (Permease DTO10_03315 ENOG4105C8U phosphate abc transporter DTO10_03320 ENOG4105EXS phosphate abc transporter DTO10_03325 ENOG4107RF6 penicillin-binding protein DTO10_03340 ENOG4105SXS Protein of unknown function (DUF456) DTO10_03355 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DTO10_03360 ENOG41063Y9 DTO10_03365 ENOG4108U5J '-nucleotidase DTO10_03370 ENOG4105N80 Ferric uptake regulator, Fur family DTO10_03375 ENOG4105FAV ABC, transporter DTO10_03380 ENOG4105FDK ABC transporter DTO10_03390 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) DTO10_03405 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DTO10_03410 ENOG4105EGD dinuclear metal center protein, YbgI family DTO10_03430 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DTO10_03435 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DTO10_03440 ENOG4107XJU UPF0178 protein DTO10_03445 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) DTO10_03455 ENOG4105C38 Glycyl-tRNA synthetase beta subunit DTO10_03460 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit DTO10_03465 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) DTO10_03475 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DTO10_03480 ENOG4105KG3 cytidine deaminase DTO10_03485 ENOG4107YR5 Diacylglycerol kinase DTO10_03490 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DTO10_03495 ENOG4105CTJ Metal Dependent Phosphohydrolase DTO10_03500 ENOG4105C9A Phoh family DTO10_03510 ENOG41068P3 sporulation protein YqfC DTO10_03520 ENOG4105DI5 UPF0365 protein DTO10_03525 ENOG4105F7J membrane-bound serine protease DTO10_03530 ENOG4105KTH gatB Yqey DTO10_03535 ENOG4105VCC 30S ribosomal protein S21 DTO10_03545 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DTO10_03550 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DTO10_03555 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DTO10_03560 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) DTO10_03565 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DTO10_03570 ENOG4105CFG Acts as a chaperone (By similarity) DTO10_03575 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DTO10_03580 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) DTO10_03585 ENOG4105CSA Coproporphyrinogen iii oxidase DTO10_03590 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) DTO10_03600 ENOG4108ZRV stage ii sporulation protein p DTO10_03615 ENOG4105TQK DNA polymerase iii, delta' subunit DTO10_03625 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DTO10_03630 ENOG4108UK2 deaminase DTO10_03635 ENOG4105KQC Competence protein DTO10_03645 ENOG4105DXX methyltransferase DTO10_03655 ENOG4108WF2 Metal Dependent Phosphohydrolase DTO10_03660 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) DTO10_03665 ENOG410812S Rna-binding protein DTO10_03675 ENOG4105CQW ribosome biogenesis GTPase YqeH DTO10_03680 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DTO10_03690 ENOG4105DJ4 phosphatidylserine decarboxylase DTO10_03695 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DTO10_03710 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DTO10_03730 ENOG4105C28 cystathionine DTO10_03760 ENOG4107XRG penicillin-binding protein DTO10_03765 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DTO10_03770 ENOG4105DBI uridine monophosphokinase DTO10_03775 ENOG4105CFP Peptidase U32 DTO10_03780 ENOG4105XYU peptidase (U32 family) DTO10_03785 ENOG4108VQJ O-methyltransferase DTO10_03790 ENOG4105HHA aminodeoxychorismate lyase DTO10_03795 ENOG4105VPH UPF0473 protein DTO10_03800 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DTO10_03805 ENOG4105VBH UPF0297 protein DTO10_03815 ENOG4105C02 permease DTO10_03820 ENOG41060CR DTO10_03835 ENOG4108V0P LemA family DTO10_03840 ENOG4105C7H Helicase, RecD TraA family DTO10_03850 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DTO10_03855 ENOG4105C3J Cysteine desulfurase DTO10_03870 ENOG4105D1H recombination factor protein RarA DTO10_03880 ENOG4106UIA DTO10_03885 ENOG4105CZV ABC transporter DTO10_03890 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DTO10_03925 ENOG4105HTX biosynthesis protein DTO10_03930 ENOG4108QV3 biosynthesis protein DTO10_03940 ENOG4105C1B dTDP-glucose 4-6-dehydratase DTO10_03980 ENOG4105C6Y Udp-glucose 6-dehydrogenase DTO10_04000 ENOG4107RA4 Glycosyl transferase (Group 1 DTO10_04020 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DTO10_04030 ENOG4108RB3 Capsular polysaccharide biosynthesis protein DTO10_04035 ENOG4107YJ4 chain length determinant protein DTO10_04040 ENOG4105HTX biosynthesis protein DTO10_04065 ENOG4105CZM Major Facilitator DTO10_04080 ENOG4108ZJ4 polysaccharide deacetylase DTO10_04090 ENOG4108IV0 ABC, transporter DTO10_04095 ENOG4105C0Z ABC transporter DTO10_04100 ENOG4105CF8 branched-chain amino acid ABC transporter, permease DTO10_04105 ENOG4105C32 Amino acid ABC transporter (Permease) DTO10_04110 ENOG4105CP9 extracellular ligand-binding receptor DTO10_04115 ENOG4108IV0 ABC, transporter DTO10_04120 ENOG4105C0Z ABC transporter DTO10_04125 ENOG4105CF8 branched-chain amino acid ABC transporter, permease DTO10_04130 ENOG4105C32 Amino acid ABC transporter (Permease) DTO10_04135 ENOG4105CP9 extracellular ligand-binding receptor DTO10_04140 ENOG4105CUZ uba thif-type nad fad binding protein DTO10_04165 ENOG4105C9M aspartyl-trna synthetase DTO10_04170 ENOG4105CUT histidyl-tRNA synthetase DTO10_04175 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DTO10_04180 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DTO10_04185 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DTO10_04190 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) DTO10_04195 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DTO10_04200 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DTO10_04210 ENOG4105CKP Polysaccharide Biosynthesis Protein DTO10_04215 ENOG4108QG2 Membrane DTO10_04220 ENOG4105NAP DTO10_04225 ENOG4105VIE preprotein translocase, subunit YajC DTO10_04235 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DTO10_04240 ENOG41061AI Protein of unknown function (DUF2905) DTO10_04250 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DTO10_04295 ENOG4108JJB ABC transporter DTO10_04300 ENOG4108JJB ABC transporter DTO10_04305 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DTO10_04315 ENOG4105FDP GntR family transcriptional regulator DTO10_04335 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DTO10_04340 ENOG4108IYU L-aspartate oxidase DTO10_04355 ENOG4105CQC Prephenate dehydratase DTO10_04360 ENOG41090I5 UPF0735 ACT domain-containing protein DTO10_04365 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DTO10_04375 ENOG4105K46 50S ribosomal protein l27 DTO10_04380 ENOG4105X36 (ribosomal) protein DTO10_04385 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) DTO10_04390 ENOG4105C03 ribonuclease DTO10_04405 ENOG41060GV RNA binding s1 domain protein DTO10_04410 ENOG4107QMS site-determining protein DTO10_04425 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DTO10_04430 ENOG4105DFF Rod shape-determining protein mreb DTO10_04435 ENOG4105W5Q DNA repair protein (RadC DTO10_04440 ENOG4108Z03 MAF-like protein DTO10_04450 ENOG4106A3R peptidase DTO10_04455 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DTO10_04465 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) DTO10_04470 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DTO10_04480 ENOG4106AR7 Spore coat protein DTO10_04485 ENOG41068KH stage VI sporulation protein D DTO10_04485 ENOG41068KH stage VI sporulation protein D DTO10_04490 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DTO10_04495 ENOG4105D52 delta-aminolevulinic acid dehydratase DTO10_04505 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DTO10_04515 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) DTO10_04525 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) DTO10_04530 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) DTO10_04535 ENOG4108IUQ atp-dependent protease DTO10_04540 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) DTO10_04545 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DTO10_04555 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DTO10_04560 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DTO10_04570 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DTO10_04575 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DTO10_04580 ENOG4108ZP8 Acetolactate synthase small subunit DTO10_04585 ENOG4105C7K acetolactate synthase DTO10_04595 ENOG4105CNI cell division protein FtsW DTO10_04655 ENOG4105M59 Phosphodiesterase, mj0936 family DTO10_04660 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DTO10_04680 ENOG4108XJQ germination protein DTO10_04695 ENOG41067TZ transcriptional regulator, MarR family DTO10_04700 ENOG4105PFC Transcriptional regulator DTO10_04735 ENOG4105E33 succinate dehydrogenase DTO10_04745 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DTO10_04765 ENOG4105K63 Thioredoxin DTO10_04770 ENOG4105C10 Electron transfer flavoprotein DTO10_04775 ENOG4105BZJ Electron transfer flavoprotein DTO10_04780 ENOG41060WC Enoyl-CoA hydratase DTO10_04785 ENOG4107Z3H Transcriptional regulator, TetR family DTO10_04790 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_04805 ENOG4105C98 muts2 protein DTO10_04810 ENOG4105DCG PHP domain protein DTO10_04820 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) DTO10_04825 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DTO10_04835 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DTO10_04840 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) DTO10_04845 ENOG4108RWN rrna methyltransferase DTO10_04850 ENOG41067MF small acid-soluble spore protein DTO10_04870 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DTO10_04875 ENOG4105CQB FAD linked oxidase domain protein DTO10_04885 ENOG4105DAA L-lactate DTO10_04890 ENOG4105JXH GntR family transcriptional regulator DTO10_04895 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DTO10_04900 ENOG4107QR9 Iron-sulfur cluster binding protein DTO10_04905 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) DTO10_04910 ENOG4105CN9 Peptidase m42 family protein DTO10_04930 ENOG410696E Membrane DTO10_04935 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DTO10_04945 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DTO10_04955 ENOG4105C22 threonyL-tRNA synthetase DTO10_04960 ENOG4108TDW sporulation protein YtxC DTO10_04975 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) DTO10_04980 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DTO10_04985 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DTO10_05000 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DTO10_05005 ENOG4105C2M dna polymerase I DTO10_05010 ENOG4105EPW hflc protein DTO10_05015 ENOG4107QJR hflk protein DTO10_05020 ENOG4105BZU Histidine kinase DTO10_05025 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DTO10_05035 ENOG4108HMX isocitrate dehydrogenase (NADP) DTO10_05040 ENOG4105BZN citrate synthase DTO10_05045 ENOG4107CWS Protein of unknown function (DUF441) DTO10_05050 ENOG4108REF Sporulation integral membrane protein ytvi DTO10_05060 ENOG4107QP3 malate synthase g DTO10_05070 ENOG4105CA9 Pyruvate kinase DTO10_05075 ENOG4105CTQ phosphohexokinase DTO10_05080 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) DTO10_05085 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) DTO10_05090 ENOG4107YCY Transcriptional regulator DTO10_05095 ENOG4105C6K Malic enzyme DTO10_05100 ENOG4105C0B DNA polymerase III (alpha subunit) DTO10_05105 ENOG4105VV2 DTO10_05115 ENOG4105SFS phosphoesterase RecJ domain protein DTO10_05135 ENOG4105E8R UPF0173 metal-dependent hydrolase DTO10_05140 ENOG4105DC7 peptidase M24 DTO10_05145 ENOG4107YZX Universal stress protein DTO10_05150 ENOG4105CH7 arginosuccinase DTO10_05155 ENOG4105CDH Citrulline--aspartate ligase DTO10_05165 ENOG4105EPU Molybdenum cofactor synthesis domain protein DTO10_05170 ENOG4105EU9 DTO10_05175 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DTO10_05185 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DTO10_05190 ENOG4105KBJ sporulation protein ytfj DTO10_05200 ENOG4105VK3 rdd domain containing protein DTO10_05205 ENOG4105D07 Signal peptide peptidase, SppA DTO10_05210 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DTO10_05215 ENOG4108RE7 deoxyribonuclease DTO10_05225 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DTO10_05235 ENOG4105D2X ABC transporter substrate-binding protein DTO10_05245 ENOG4105FR1 rard protein DTO10_05250 ENOG4105EFZ amidohydrolase DTO10_05255 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DTO10_05265 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) DTO10_05275 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) DTO10_05280 ENOG4108W76 histidinol phosphate phosphatase hisj family DTO10_05295 ENOG4105BZU Histidine kinase DTO10_05300 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) DTO10_05305 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DTO10_05320 ENOG4105F1V Acetoin utilization protein DTO10_05325 ENOG4105W87 Cbs domain DTO10_05330 ENOG4105DGU Histone deacetylase DTO10_05335 ENOG4105ETE Transcriptional regulator (LacI family DTO10_05340 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DTO10_05345 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DTO10_05365 ENOG4105C88 aminopeptidase DTO10_05370 ENOG4105DFU Cell wall formation (By similarity) DTO10_05385 ENOG4108NKM UPF0354 protein DTO10_05400 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ DTO10_05405 ENOG41086D8 Transcriptional regulator DTO10_05410 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DTO10_05425 ENOG4105C8F Beta-lactamase domain protein DTO10_05430 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DTO10_05440 ENOG4108V15 phosphotransferase enzyme family DTO10_05465 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DTO10_05470 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DTO10_05475 ENOG4108JJB ABC transporter DTO10_05490 ENOG4105CHU acetyl-coa acetyltransferase DTO10_05495 ENOG4107F3J Amp-dependent synthetase and ligase DTO10_05500 ENOG4107ZYJ bioY protein DTO10_05510 ENOG4107QSE Dipeptidase DTO10_05515 ENOG4107R73 Mate efflux family protein DTO10_05525 ENOG4107ZTW SNARE associated Golgi DTO10_05560 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DTO10_05565 ENOG4105EXQ uroporphyrinogen iii synthase hem4 DTO10_05570 ENOG4107ZXU DSBA oxidoreductase DTO10_05580 ENOG4108RNG Permease of the drug metabolite transporter DTO10_05590 ENOG4105CUT histidyl-tRNA synthetase DTO10_05600 ENOG4108PJD permease DTO10_05630 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DTO10_05635 ENOG4105CJZ response regulator DTO10_05640 ENOG4105EWM Histidine kinase DTO10_05645 ENOG4105C19 ABC transporter DTO10_05650 ENOG4108HVR ABC transporter, permease DTO10_05660 ENOG4105D7V transposase DTO10_05675 ENOG4105YW5 deoR family transcriptional regulator DTO10_05690 ENOG4105CBX hi0933 family DTO10_05710 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DTO10_05720 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DTO10_05725 ENOG41085GJ domain protein DTO10_05730 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DTO10_05740 ENOG4105CV8 reductase DTO10_05745 ENOG4105F27 Major Facilitator DTO10_05750 ENOG4105KVH Transcriptional regulator DTO10_05765 ENOG4105PF9 Transcriptional regulator DTO10_05805 ENOG4108IG5 Transcriptional regulator DTO10_05815 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DTO10_05820 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DTO10_05825 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DTO10_05830 ENOG4105C8Q Methyl-accepting chemotaxis DTO10_05860 ENOG4105K7W phage-related replication protein DTO10_05865 ENOG4105K4H Nlp p60 protein DTO10_05880 ENOG4105KVH Transcriptional regulator DTO10_05890 ENOG4108YYS metal-dependent hydrolase (By similarity) DTO10_05900 ENOG4105KD7 acetyltransferase DTO10_05905 ENOG4105KRN Transcriptional regulator, abrb family DTO10_05920 ENOG41080TC multidrug resistance protein DTO10_05950 ENOG4105E1K spore germination protein DTO10_05955 ENOG4107T5V SNARE associated Golgi DTO10_05960 ENOG410841Q phosphoesterase PA-phosphatase related protein DTO10_05965 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DTO10_05980 ENOG4105F04 LysR family Transcriptional regulator DTO10_05985 ENOG4105DJ2 Major Facilitator Superfamily DTO10_05995 ENOG4105EFZ amidohydrolase DTO10_06005 ENOG4105D82 Glutamate dehydrogenase DTO10_06010 ENOG4105C8Y Acetylornithine aminotransferase DTO10_06015 ENOG4105C26 Dehydrogenase DTO10_06020 ENOG4108JUB Transcriptional regulator DTO10_06030 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DTO10_06040 ENOG4105RHA ABC transporter, permease DTO10_06045 ENOG4108IUX (ABC) transporter DTO10_06055 ENOG4107R73 Mate efflux family protein DTO10_06060 ENOG4108JQ7 (ABC) transporter DTO10_06065 ENOG4105C3U ABC transporter DTO10_06070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DTO10_06090 ENOG4105CDA abc transporter atp-binding protein DTO10_06095 ENOG4105E5Q amino acid AbC transporter DTO10_06100 ENOG4105EAB amino acid AbC transporter DTO10_06110 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase DTO10_06115 ENOG4105ETD TRANSCRIPTIONal DTO10_06120 ENOG4105CTS PTS system mannitol-specific DTO10_06125 ENOG4105D4T Citrate transporter DTO10_06130 ENOG4108MRH transcriptional regulatory protein DTO10_06135 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DTO10_06150 ENOG4105D03 DNA-3-methyladenine glycosylase II DTO10_06165 ENOG4105CHR reductase DTO10_06175 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DTO10_06185 ENOG41081VB Hydrolase DTO10_06205 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DTO10_06265 ENOG4107QIV Cytochrome c biogenesis protein DTO10_06285 ENOG4105WH1 Two component transcriptional regulator luxr family DTO10_06290 ENOG4105ENE Histidine kinase DTO10_06310 ENOG4105XEA Tetr family transcriptional regulator DTO10_06315 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) DTO10_06320 ENOG4105C85 amino acid DTO10_06325 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) DTO10_06330 ENOG4106IPI cyclase, family DTO10_06335 ENOG4105N14 lysine exporter protein LysE YggA DTO10_06345 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) DTO10_06350 ENOG4107RZC phospholipase d DTO10_06370 ENOG4107RSM transcriptional regulator DTO10_06375 ENOG4105ECB domain protein DTO10_06380 ENOG4105C0R drug resistance transporter emrb qaca subfamily DTO10_06385 ENOG41067SE Tetr family transcriptional regulator DTO10_06405 ENOG4105CN5 Metallo-Beta-Lactamase DTO10_06410 ENOG4105C22 threonyL-tRNA synthetase DTO10_06420 ENOG4108IQI permease DTO10_06430 ENOG4107S4Y M20 DapE family protein YgeY DTO10_06435 ENOG4105CHU acetyl-coa acetyltransferase DTO10_06450 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DTO10_06470 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DTO10_06475 ENOG4108JUB Transcriptional regulator DTO10_06495 ENOG4105KIR Thiol-disulfide oxidoreductase dcc DTO10_06540 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DTO10_06565 ENOG4107QM2 Aldo Keto reductase DTO10_06570 ENOG4107QN1 sodium solute DTO10_06650 ENOG4106ANW SMI1_KNR4 DTO10_06660 ENOG4106BHF DTO10_06670 ENOG4105CSH Transporter DTO10_06675 ENOG4105CIF Ornithine Cyclodeaminase DTO10_06695 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DTO10_06705 ENOG4105EEM helicase DTO10_06720 ENOG4105DWT malate dehydrogenase (quinone) DTO10_06725 ENOG4105DTD Dehydrogenase DTO10_06735 ENOG4105CY2 Citrate transporter DTO10_06740 ENOG4105CMU LysR family (Transcriptional regulator DTO10_06780 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DTO10_06785 ENOG4108JQ1 Dehydrogenase DTO10_06790 ENOG4105C54 Major Facilitator superfamily DTO10_06795 ENOG4105NWF RbsD or FucU transport DTO10_06800 ENOG4105ERH Fumarylacetoacetate hydrolase DTO10_06805 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DTO10_06810 ENOG4105CHR reductase DTO10_06825 ENOG4105GAK amidohydrolase 2 DTO10_06845 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein DTO10_06870 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DTO10_06900 ENOG4105EXW epimerase dehydratase DTO10_06915 ENOG4105N14 lysine exporter protein LysE YggA DTO10_06930 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain DTO10_06935 ENOG4108URH decarboxylase DTO10_06945 ENOG4108JCI Transcriptional regulator DTO10_06985 ENOG4105K6H D-cysteine desulfhydrase DTO10_06990 ENOG4105KME endoribonuclease L-psp DTO10_06995 ENOG4108IQI permease DTO10_07005 ENOG4105C87 Aminotransferase class I and II DTO10_07015 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase DTO10_07040 ENOG4105CZ9 Domain of unknown function (DU1801) DTO10_07045 ENOG41082YX Transcriptional regulator, arsr family DTO10_07050 ENOG4105DQ6 Transposase DTO10_07060 ENOG4108QY0 Membrane DTO10_07070 ENOG4107BMA Transglycosylase associated protein DTO10_07080 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DTO10_07135 ENOG4105JVQ RNA Polymerase DTO10_07165 ENOG4105FS7 Transcriptional regulator DTO10_07170 ENOG4108TVJ Nitroreductase DTO10_07180 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) DTO10_07195 ENOG4105CUB amino acid DTO10_07200 ENOG4105EFZ amidohydrolase DTO10_07225 ENOG4108HWY Beta-lactamase DTO10_07230 ENOG4108S01 response regulator DTO10_07235 ENOG4105ECK Fatty Acid Desaturase DTO10_07240 ENOG4108IJ0 Aspartate ammonia-lyase DTO10_07245 ENOG4105HDK L-asparaginase DTO10_07250 ENOG4108IMY Transcriptional regulator DTO10_07255 ENOG4105E0A ABC, transporter DTO10_07260 ENOG4108U1V ABC transporter, permease DTO10_07265 ENOG4105DQ5 transport system permease protein DTO10_07270 ENOG4108HUF Transporter DTO10_07275 ENOG410667J hydrolase DTO10_07305 ENOG4105CHJ isochorismatase hydrolase DTO10_07325 ENOG4105C0R drug resistance transporter emrb qaca subfamily DTO10_07330 ENOG4105J7D transcriptional regulator DTO10_07340 ENOG4108VQJ O-methyltransferase DTO10_07355 ENOG4105DY9 regulatoR DTO10_07360 ENOG4108HRK Histidine kinase DTO10_07365 ENOG4105EGI Transcriptional regulator DTO10_07380 ENOG4105C98 muts2 protein DTO10_07385 ENOG4105CPN adenine deaminase DTO10_07390 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DTO10_07395 ENOG4105F38 ABC transporter, permease DTO10_07400 ENOG4105F38 ABC transporter, permease DTO10_07430 ENOG4105ES4 Nitrilase DTO10_07460 ENOG4105F11 amine oxidase DTO10_07465 ENOG4105C26 Dehydrogenase DTO10_07470 ENOG41086KC Transcriptional regulator DTO10_07475 ENOG4105DTE Xanthine uracil vitamin C permease DTO10_07485 ENOG4105DZC cytosine deaminase DTO10_07490 ENOG4105DZC cytosine deaminase DTO10_07495 ENOG4105DZC cytosine deaminase DTO10_07500 ENOG4105DEF Extracellular solute-binding protein, family 5 DTO10_07505 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DTO10_07510 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DTO10_07515 ENOG4105DEF Extracellular solute-binding protein, family 5 DTO10_07520 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DTO10_07530 ENOG4105C3U ABC transporter DTO10_07535 ENOG4108JQ7 (ABC) transporter DTO10_07540 ENOG4108HRK Histidine kinase DTO10_07545 ENOG410874W AraC family transcriptional regulator DTO10_07555 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DTO10_07565 ENOG4105CNG UPF0061 protein DTO10_07595 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DTO10_07645 ENOG410870W N-acetyltransferase DTO10_07665 ENOG4105Z7P Acetyltransferase (GNAT) family DTO10_07695 ENOG41080HJ 6-phospho 3-hexuloisomerase DTO10_07700 ENOG4108VA3 3-hexulose-6-phosphate synthase DTO10_07710 ENOG4105D7K pfkb domain protein DTO10_07720 ENOG4108M60 Transcriptional regulator DTO10_07730 ENOG41069DP small acid-soluble spore protein DTO10_07735 ENOG4105RHY Pfam:UPF0157 DTO10_07760 ENOG4108TU7 Inherit from COG: (ABC) transporter DTO10_07765 ENOG4105CJ1 ABC, transporter DTO10_07790 ENOG41068WN DTO10_07795 ENOG41069ER domain protein DTO10_07800 ENOG4105EUB pirin domain protein DTO10_07805 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DTO10_07810 ENOG4105DDI hemolysin-type calcium-binding region DTO10_07820 ENOG4105CG5 Glycosyl transferase (Group 1 DTO10_07825 ENOG4107SJB teichoic acid biosynthesis DTO10_07830 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DTO10_07840 ENOG4107TIF Phenazine biosynthesis protein, PhzF family DTO10_07855 ENOG4105K6V RNA polymerase DTO10_07865 ENOG4105CIN aminoacyl-histidine dipeptidase DTO10_07890 ENOG4105C0A alcohol dehydrogenase DTO10_07910 ENOG4108Q8B Spore germination protein DTO10_07915 ENOG4108NHD germination protein DTO10_07925 ENOG4105CZN Potassium uptake protein DTO10_07940 ENOG4106SCS STAS domain DTO10_07945 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) DTO10_07955 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DTO10_07975 ENOG4105CMR udp-glucose 4-epimerase DTO10_07980 ENOG4107SJB teichoic acid biosynthesis DTO10_07985 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DTO10_07990 ENOG4108RYK Nad-dependent epimerase dehydratase DTO10_07995 ENOG4108Z40 Transcriptional regulator DTO10_08005 ENOG4107ZQN disulfide bond DTO10_08010 ENOG4108Z40 Transcriptional regulator DTO10_08035 ENOG41082BM Transcriptional regulator, arsr family DTO10_08040 ENOG4105ECB domain protein DTO10_08045 ENOG41062ES Transcriptional regulator DTO10_08050 ENOG4105SZ6 Thioredoxin DTO10_08080 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase DTO10_08100 ENOG4107MII Sugar-specific transcriptional regulator TrmB DTO10_08105 ENOG4105CZM Major Facilitator DTO10_08120 ENOG4105CZV ABC transporter DTO10_08145 ENOG4105RHY Pfam:UPF0157 DTO10_08165 ENOG4107T5V SNARE associated Golgi DTO10_08185 ENOG41062D9 Histidine kinase DTO10_08190 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DTO10_08205 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DTO10_08210 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DTO10_08235 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) DTO10_08240 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DTO10_08265 ENOG4105DUX Transporter DTO10_08275 ENOG4108P49 AntiSigma factor DTO10_08280 ENOG4105JVQ RNA Polymerase DTO10_08285 ENOG4108ZJ4 polysaccharide deacetylase DTO10_08305 ENOG4107FQ9 ethanolamine ammonia-lyase DTO10_08310 ENOG4105CPD ethanolamine ammonia-lyase DTO10_08315 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase DTO10_08335 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DTO10_08355 ENOG4107T89 von Willebrand factor, type A DTO10_08360 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DTO10_08370 ENOG4108UW5 maltose o-acetyltransferase DTO10_08380 ENOG4105X5K response regulator receiver protein DTO10_08390 ENOG4105BZ8 glutamate synthase DTO10_08395 ENOG4105CBC glutamate synthase DTO10_08400 ENOG4105C5Q Transcriptional regulator DTO10_08415 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DTO10_08420 ENOG4105C8T Leucyl-tRNA synthetase DTO10_08435 ENOG4105N5T Radical SAM Protein DTO10_08450 ENOG4105E8V Alpha Beta Hydrolase Fold protein DTO10_08455 ENOG4108Z0R Transferase DTO10_08460 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP DTO10_08495 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DTO10_08500 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DTO10_08530 ENOG4105EWC Purine nucleoside phosphorylase DTO10_08545 ENOG4105D2X ABC transporter substrate-binding protein DTO10_08555 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DTO10_08560 ENOG41062IR nudix hydrolase DTO10_08575 ENOG4108RMU ferritin dps family protein DTO10_08585 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) DTO10_08590 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) DTO10_08595 ENOG4105DSE periplasmic solute binding protein DTO10_08600 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DTO10_08605 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DTO10_08610 ENOG4108MRH transcriptional regulatory protein DTO10_08615 ENOG4105DTQ mandelate racemase muconate lactonizing DTO10_08620 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_08625 ENOG4108IPT Naphthoate synthase DTO10_08630 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DTO10_08635 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) DTO10_08640 ENOG4105E4F Isochorismate synthase DTO10_08645 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DTO10_08775 ENOG4108RNG Permease of the drug metabolite transporter DTO10_08780 ENOG4105KT7 mgtC SapB transporter DTO10_08800 ENOG4105C26 Dehydrogenase DTO10_08805 ENOG4105CK7 Sodium proline symporter DTO10_08810 ENOG4107YHD transcriptional regulator DTO10_08825 ENOG4108W8B Beta-lactamase domain protein DTO10_08840 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DTO10_08870 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DTO10_08900 ENOG4108IQI permease DTO10_08920 ENOG4105D17 glycoside hydrolase, family 3 domain protein DTO10_08935 ENOG4108NGU Transcriptional regulator DTO10_08950 ENOG4107ZE5 PPIases accelerate the folding of proteins DTO10_08960 ENOG4105BZU Histidine kinase DTO10_08970 ENOG41085AS UPF0473 protein DTO10_08985 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DTO10_08990 ENOG4105WDJ 50S ribosomal protein L33 DTO10_08995 ENOG4105CKI cobalamin synthesis protein DTO10_09000 ENOG4105PKS Excinuclease abc c subunit domain protein DTO10_09015 ENOG4105G6Z alkaline phosphatase DTO10_09025 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR DTO10_09050 ENOG41086DT Membrane protein of unknown function DTO10_09055 ENOG4105WAB arsR family transcriptional regulator DTO10_09060 ENOG4105F27 Major Facilitator DTO10_09065 ENOG4108K8S endonuclease I DTO10_09070 ENOG4105C85 amino acid DTO10_09095 ENOG4105E1K spore germination protein DTO10_09100 ENOG4105CGH 5'-nucleotidase DTO10_09120 ENOG4106DF4 Sigma-70, region 4 DTO10_09150 ENOG4105D94 Major Facilitator Superfamily DTO10_09155 ENOG4107R7I amino acid DTO10_09160 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DTO10_09165 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DTO10_09175 ENOG4105VRS hydrolase family 18 DTO10_09185 ENOG4107PBV potassium channel DTO10_09200 ENOG4107QW4 alcohol dehydrogenase DTO10_09205 ENOG4105WG9 Conserved Protein DTO10_09220 ENOG4105CHM Aminotransferase DTO10_09225 ENOG4108ZB6 transcriptional regulator AsnC family DTO10_09230 ENOG4108MUZ hydrolase DTO10_09240 ENOG4105C87 Aminotransferase class I and II DTO10_09250 ENOG4108QCI YvbH-like oligomerisation region DTO10_09255 ENOG4108YM7 Gcn5-related n-acetyltransferase DTO10_09265 ENOG4105J7D transcriptional regulator DTO10_09275 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) DTO10_09280 ENOG4105Y38 Kinase-associated protein B DTO10_09290 ENOG4105BZ4 penicillin-binding protein DTO10_09295 ENOG4105BZ4 penicillin-binding protein DTO10_09300 ENOG4105D65 subunit l DTO10_09305 ENOG4105HC0 Na H antiporter DTO10_09310 ENOG4108ZE9 Monovalent cation H antiporter subunit C DTO10_09315 ENOG4108JPZ Monovalent cation H antiporter subunit D DTO10_09320 ENOG4105SC1 monovalent cation H antiporter subunit E DTO10_09330 ENOG4105KJM monovalent cation h antiporter subunit g DTO10_09340 ENOG4105KA0 thioesterase Superfamily protein DTO10_09345 ENOG4108UX3 '-nucleotidase DTO10_09355 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DTO10_09360 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DTO10_09370 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DTO10_09385 ENOG41069ER domain protein DTO10_09400 ENOG4105CEP NADH dehydrogenase DTO10_09415 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DTO10_09435 ENOG41083MR nifu domain-containing protein DTO10_09440 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DTO10_09445 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) DTO10_09450 ENOG4105D6E homoserine dehydrogenase DTO10_09465 ENOG4108W5N phosphatidylglycerophosphatase a DTO10_09470 ENOG4105D4U had-superfamily hydrolase, subfamily iia DTO10_09490 ENOG4105MMD transcriptional regulator DTO10_09495 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DTO10_09500 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DTO10_09505 ENOG4105FAA peptidase M23 DTO10_09510 ENOG4108YTE sporulation protein YunB DTO10_09515 ENOG4105CPI Metal Dependent Phosphohydrolase DTO10_09520 ENOG4105KZD Domain of unknown function (DUF1805) DTO10_09525 ENOG4107R8B 5'-nucleotidase DTO10_09535 ENOG4105I3N Conserved Protein DTO10_09540 ENOG4105DIW FeS assembly protein SUFB DTO10_09545 ENOG4108UNV SUF system FeS assembly protein, NifU family DTO10_09555 ENOG4105JRK feS assembly protein SufD DTO10_09560 ENOG4105C3K feS assembly ATPase SufC DTO10_09570 ENOG4105D7V transposase DTO10_09575 ENOG4105D01 (LipO)protein DTO10_09580 ENOG4108UMI ABC transporter, permease DTO10_09585 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DTO10_09605 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DTO10_09610 ENOG41080E8 Transcriptional regulator, Spx MgsR family DTO10_09615 ENOG4105C1G acyl-Coa dehydrogenase DTO10_09620 ENOG4105CHU acetyl-coa acetyltransferase DTO10_09655 ENOG4105CC5 ABC transporter DTO10_09660 ENOG4105CC5 ABC transporter DTO10_09665 ENOG4105DIK (ABC) transporter DTO10_09670 ENOG4105DSE periplasmic solute binding protein DTO10_09685 ENOG4108IQI permease DTO10_09690 ENOG4105CG3 alpha amylase, catalytic region DTO10_09705 ENOG4105KPY Small multidrug resistance protein DTO10_09735 ENOG4105JSC dimethylmenaquinone methyltransferase DTO10_09740 ENOG4105E0M Sulfatase DTO10_09750 ENOG4108IPW abc transporter atp-binding protein DTO10_09755 ENOG4105CM4 permease protein DTO10_09760 ENOG4105DHS permease protein DTO10_09765 ENOG4105ZKE UPF0349 protein DTO10_09775 ENOG4105EWU Squalene--hopene cyclase DTO10_09790 ENOG41062D9 Histidine kinase DTO10_09795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DTO10_09800 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DTO10_09805 ENOG4108S01 response regulator DTO10_09810 ENOG4108ZGX Histidine kinase DTO10_09815 ENOG4105ECK Fatty Acid Desaturase DTO10_09820 ENOG4108MRH transcriptional regulatory protein DTO10_09825 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DTO10_09840 ENOG4105JN3 extra-cytoplasmic solute receptor family protein DTO10_09850 ENOG4108KAM Transcriptional regulator DTO10_09855 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DTO10_09860 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DTO10_09865 ENOG4108JB9 formate dehydrogenase DTO10_09875 ENOG4105D1F ATP-binding protein DTO10_09885 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold DTO10_09895 ENOG4105C0R drug resistance transporter emrb qaca subfamily DTO10_09905 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) DTO10_09910 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DTO10_09920 ENOG4105XZU Preprotein translocase, subunit SecG DTO10_09930 ENOG4108VXD carboxy-peptidase DTO10_09950 ENOG4105BZA Phosphoglycerate kinase DTO10_09955 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DTO10_09970 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DTO10_09980 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DTO10_09985 ENOG4105KRI phosphocarrier protein (HPr DTO10_09995 ENOG4105CHW UPF0052 protein DTO10_10000 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DTO10_10005 ENOG4108Z4K mutator MutT protein DTO10_10010 ENOG4105C3M thioredoxin reductase DTO10_10020 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DTO10_10025 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DTO10_10030 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DTO10_10035 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DTO10_10040 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DTO10_10045 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DTO10_10050 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DTO10_10055 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) DTO10_10070 ENOG4108S4C acetyltransferase DTO10_10075 ENOG4107XGZ Hydrolase DTO10_10080 ENOG4105HKU nucleoside recognition domain-containing protein DTO10_10090 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) DTO10_10100 ENOG4108PY7 DTO10_10105 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DTO10_10110 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DTO10_10120 ENOG4105CH6 catalase DTO10_10125 ENOG4105EYF MMPL domain protein DTO10_10130 ENOG4108YYC ycei family DTO10_10135 ENOG4108IHU transport system permease protein DTO10_10140 ENOG4105DQ5 transport system permease protein DTO10_10145 ENOG4108MES Periplasmic binding protein DTO10_10155 ENOG4105CN1 protease DTO10_10165 ENOG4105CRP Part of the ABC transporter FtsEX involved in DTO10_10170 ENOG4105CAK Cell division ATP-binding protein ftsE DTO10_10190 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DTO10_10195 ENOG4108IMY Transcriptional regulator DTO10_10210 ENOG4105MS2 ribosomal subunit Interface protein DTO10_10220 ENOG4105MQ3 flagellar protein FliS DTO10_10225 ENOG4107RT6 flagellar hook-associated DTO10_10230 ENOG41083S7 flagellar protein FlaG DTO10_10235 ENOG4105I03 Flagellin DTO10_10240 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) DTO10_10245 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) DTO10_10250 ENOG4105MKD DTO10_10255 ENOG4105DTJ flagellar hook-associated protein DTO10_10260 ENOG4105E1Q flagellar hook-associated protein DTO10_10275 ENOG4105RU3 DTO10_10295 ENOG4105WH1 Two component transcriptional regulator luxr family DTO10_10300 ENOG4105BZU Histidine kinase DTO10_10305 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DTO10_10310 ENOG4108KGH TRANSCRIPTIONal DTO10_10315 ENOG4107VDP teichoic acid biosynthesis DTO10_10320 ENOG4105ESV Glycosyl transferase, family 4 DTO10_10325 ENOG4105W2C Glycosyl transferase DTO10_10340 ENOG4105CJR Integral membrane protein (MviN DTO10_10345 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) DTO10_10360 ENOG4107SJB teichoic acid biosynthesis DTO10_10365 ENOG4107SJB teichoic acid biosynthesis DTO10_10370 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase DTO10_10375 ENOG4107RZX Teichoic acid biosynthesis protein DTO10_10395 ENOG4108KGH TRANSCRIPTIONal DTO10_10400 ENOG4105E0M Sulfatase DTO10_10410 ENOG4106KBF Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) DTO10_10415 ENOG4105G6Z alkaline phosphatase DTO10_10420 ENOG4105JFG SpoIID LytB domain protein DTO10_10425 ENOG4108K8S endonuclease I DTO10_10430 ENOG4105CGH 5'-nucleotidase DTO10_10435 ENOG4107RVG penicillin-binding protein DTO10_10465 ENOG4105KBK Zinc finger, swim domain protein DTO10_10470 ENOG4105C0D helicase DTO10_10480 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DTO10_10485 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DTO10_10500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DTO10_10505 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DTO10_10510 ENOG4105DEF Extracellular solute-binding protein, family 5 DTO10_10515 ENOG4108JQ7 (ABC) transporter DTO10_10520 ENOG4105C3U ABC transporter DTO10_10525 ENOG4108UUM single-stranded DNA-binding protein DTO10_10550 ENOG4105CGA flagellar basal-body rod protein FlgG DTO10_10560 ENOG4105DFF Rod shape-determining protein mreb DTO10_10565 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DTO10_10570 ENOG4105FRN stage II sporulation protein DTO10_10595 ENOG4106778 Protein of unknown function (DUF1146) DTO10_10600 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DTO10_10605 ENOG4105C8S subunit m DTO10_10610 ENOG4105D65 subunit l DTO10_10615 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DTO10_10625 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DTO10_10640 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DTO10_10645 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DTO10_10650 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DTO10_10655 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DTO10_10660 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DTO10_10665 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DTO10_10670 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DTO10_10675 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DTO10_10685 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DTO10_10690 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DTO10_10695 ENOG41062M3 atp synthase DTO10_10705 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DTO10_10710 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DTO10_10715 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DTO10_10725 ENOG4108UIC UPF0340 protein DTO10_10730 ENOG4108YZG isomerase DTO10_10735 ENOG4105C8Q Methyl-accepting chemotaxis DTO10_10745 ENOG410815N Probably functions as a manganese efflux pump (By similarity) DTO10_10750 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DTO10_10755 ENOG4108ZXQ stage ii sporulation protein r DTO10_10760 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DTO10_10765 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DTO10_10780 ENOG4105KI2 Urea amidohydrolase subunit beta DTO10_10785 ENOG4105CQM Urea amidohydrolase subunit alpha DTO10_10790 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) DTO10_10795 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) DTO10_10800 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) DTO10_10805 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) DTO10_10825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DTO10_10840 ENOG4107104 thymidine kinase DTO10_10845 ENOG4105VFB Binds the 23S rRNA (By similarity) DTO10_10850 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DTO10_10855 ENOG4105CBT Fructose-1,6-bisphosphatase DTO10_10860 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DTO10_10865 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DTO10_10875 ENOG410812K response regulator receiver protein DTO10_10885 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DTO10_10895 ENOG4105D5P Methylmalonyl-coA mutase DTO10_10905 ENOG4105C1G acyl-Coa dehydrogenase DTO10_10910 ENOG4105C1G acyl-Coa dehydrogenase DTO10_10915 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DTO10_10925 ENOG4105DF6 Fe-S oxidoreductase DTO10_10940 ENOG4105C75 arginyL-tRNA synthetase DTO10_10950 ENOG4105CYW agmatinase DTO10_10955 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DTO10_10960 ENOG4105BZ4 penicillin-binding protein DTO10_10965 ENOG4108XFG YwhD family DTO10_10970 ENOG4108Z4T Peptidase M50 DTO10_10975 ENOG41069HH 4-oxalocrotonate tautomerase DTO10_10985 ENOG4105DCI Phosphohydrolase DTO10_10995 ENOG4108VCI transcription factor, rsfa family DTO10_11005 ENOG4108IJ2 phosphate acetyltransferase DTO10_11010 ENOG4107JTW chlorite dismutase DTO10_11035 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DTO10_11050 ENOG4105D06 uba thif-type nad fad binding protein DTO10_11055 ENOG41067WU Molybdopterin converting factor (Subunit 1) DTO10_11060 ENOG4108ZAF Molybdopterin DTO10_11065 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) DTO10_11070 ENOG4105DWF phosphomethylpyrimidine kinase DTO10_11080 ENOG4108TN2 lmbE family DTO10_11085 ENOG4105CZM Major Facilitator DTO10_11090 ENOG4107MII Sugar-specific transcriptional regulator TrmB DTO10_11095 ENOG4105D8V Glucose sorbosone dehydrogenase DTO10_11100 ENOG410667J hydrolase DTO10_11110 ENOG4108Z66 YbaK ebsC protein DTO10_11115 ENOG4105CMG Carbohydrate kinase DTO10_11135 ENOG4108WBT adenosyltransferase DTO10_11145 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DTO10_11150 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) DTO10_11160 ENOG4107QZB decarboxylase DTO10_11165 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) DTO10_11170 ENOG4105E0A ABC, transporter DTO10_11175 ENOG4105EHG Permease protein DTO10_11180 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) DTO10_11185 ENOG4107BJW polysaccharide deacetylase DTO10_11190 ENOG4105E0A ABC, transporter DTO10_11195 ENOG4105EHG Permease protein DTO10_11220 ENOG4108TVJ Nitroreductase DTO10_11225 ENOG4105C9U ATP-dependent DNA helicase RecQ DTO10_11230 ENOG4105C5H ABC transporter DTO10_11250 ENOG4105C1J atp-dependent rna helicase DTO10_11255 ENOG4105C7N Xanthine uracil vitamin C permease DTO10_11295 ENOG4105CIY formyltetrahydrofolate deformylase DTO10_11310 ENOG4105EAB amino acid AbC transporter DTO10_11315 ENOG4105E5Q amino acid AbC transporter DTO10_11325 ENOG4105CX6 glutaminyL-tRNA synthetase DTO10_11335 ENOG4105E0X reductase DTO10_11340 ENOG4105D9N nucleoside DTO10_11350 ENOG4105GR3 Histidine kinase DTO10_11355 ENOG4108STX response regulator DTO10_11360 ENOG4107RBB ABC transporter, permease DTO10_11365 ENOG4105C19 ABC transporter DTO10_11395 ENOG4107YUH hydrolase DTO10_11400 ENOG4105CK2 sodium dicarboxylate symporter DTO10_11410 ENOG4105DR4 Methyltransferase DTO10_11420 ENOG4105C5Q Transcriptional regulator DTO10_11425 ENOG4105D82 Glutamate dehydrogenase DTO10_11430 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DTO10_11435 ENOG4105CNN ABC, transporter DTO10_11440 ENOG4105C2J ABC transporter DTO10_11445 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) DTO10_11450 ENOG4108RVA ribokinase DTO10_11455 ENOG4105ETE Transcriptional regulator (LacI family DTO10_11480 ENOG4105DY8 decarboxylase DTO10_11505 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DTO10_11520 ENOG4107YNJ LysR family Transcriptional regulator DTO10_11525 ENOG4105C1J atp-dependent rna helicase DTO10_11535 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DTO10_11540 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DTO10_11550 ENOG4105C0H protease DTO10_11555 ENOG4105Q2H domain protein DTO10_11570 ENOG4105BZU Histidine kinase DTO10_11575 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DTO10_11605 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DTO10_11610 ENOG4105CDU Replicative dna helicase DTO10_11615 ENOG4105K9Q Binds to the 23S rRNA (By similarity) DTO10_11620 ENOG4105BZR domain protein DTO10_11630 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) DTO10_11635 ENOG4108UUM single-stranded DNA-binding protein DTO10_11640 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) DTO10_11645 ENOG4105C3G gtp-binding protein DTO10_11650 ENOG4105VDK protein, conserved in bacteria DTO10_11655 ENOG4105D8X mechanosensitive ion channel DTO10_11660 ENOG4108ZDA Sporulation protein YyaC DTO10_11665 ENOG4108UQV Membrane DTO10_11670 ENOG4105FA0 parb-like partition protein DTO10_11675 ENOG4107QJE Chromosome Partitioning Protein DTO10_11680 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) DTO10_11690 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DTO10_11695 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DTO10_11705 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DTO10_11710 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) DTO10_11715 ENOG4105VG0 50S ribosomal protein l34 DTO10_11720 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DTO10_11725 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DTO10_11730 ENOG410848D S4 domain protein YaaA DTO10_11735 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DTO10_11745 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DTO10_11750 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DTO10_11755 ENOG4105DHT Metal Dependent Phosphohydrolase DTO10_11790 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DTO10_11810 ENOG4105ZMH deoxynucleoside kinase DTO10_11820 ENOG4105GTG Isochorismatase DTO10_11825 ENOG4108Z6B deaminase DTO10_11835 ENOG4105C6E dna polymerase iii DTO10_11840 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DTO10_11845 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DTO10_11855 ENOG41067KS pro-sigma K processing DTO10_11890 ENOG4105CXN decarboxylase DTO10_11895 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) DTO10_11900 ENOG4105X0R protein from nitrogen regulatory protein P-II DTO10_11905 ENOG4105XVJ Protein of unknown function (DUF327) DTO10_11910 ENOG4105FA2 dna polymerase iii DTO10_11915 ENOG4105MA4 psp1 domain protein DTO10_11920 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) DTO10_11925 ENOG41060K3 Methyltransferase DTO10_11935 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DTO10_11940 ENOG4105KRN Transcriptional regulator, abrb family DTO10_11950 ENOG4105F8V Hydrolase, tatD family DTO10_11955 ENOG41069ER domain protein DTO10_11960 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DTO10_11965 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DTO10_11970 ENOG4105XFA sporulation peptidase YabG DTO10_11975 ENOG4105W42 Veg protein DTO10_11985 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) DTO10_11990 ENOG4105DFT pur operon repressor DTO10_11995 ENOG4105KME endoribonuclease L-psp DTO10_12000 ENOG4105K4W Could be involved in septation (By similarity) DTO10_12005 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DTO10_12010 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DTO10_12015 ENOG4105GVF (ABC) transporter DTO10_12020 ENOG4105FBW Monooxygenase DTO10_12025 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DTO10_12030 ENOG4105E2Y ABC, transporter DTO10_12035 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) DTO10_12050 ENOG4108JA2 transcriptioN-repair coupling factor DTO10_12055 ENOG4108M14 stage v sporulation protein t DTO10_12065 ENOG4108IY2 MazG family DTO10_12070 ENOG41082I2 s4 domain protein DTO10_12075 ENOG4105VYY sporulation protein yabp DTO10_12090 ENOG41060GV RNA binding s1 domain protein DTO10_12120 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DTO10_12125 ENOG4108UGV hypoxanthine phosphoribosyltransferase DTO10_12130 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DTO10_12135 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) DTO10_12140 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DTO10_12145 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase DTO10_12150 ENOG4105C6T cysteine synthase DTO10_12155 ENOG4105EEI dihydropteroate synthase DTO10_12160 ENOG4105KRF dihydroneopterin aldolase DTO10_12165 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DTO10_12175 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DTO10_12180 ENOG4105CRK lysyL-tRNA synthetase DTO10_12205 ENOG4108Z0C Uvrb UvrC protein DTO10_12210 ENOG41066A3 ATP guanido phosphotransferase DTO10_12220 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DTO10_12225 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) DTO10_12230 ENOG4105CTP PilT protein domain protein DTO10_12235 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DTO10_12240 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) DTO10_12245 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DTO10_12250 ENOG4105D7W serine acetyltransferase DTO10_12255 ENOG4105C8N cysteinyl-tRNA synthetase DTO10_12265 ENOG4105C2N RNA methyltransferase TrmH family group 3 DTO10_12270 ENOG4105M0M Tetracycline resistance protein DTO10_12275 ENOG4105QIV RNA polymerase DTO10_12290 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DTO10_12300 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) DTO10_12310 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) DTO10_12315 ENOG4107Y49 methyltransferase DTO10_12320 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DTO10_12325 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DTO10_12330 ENOG4105XPM ribosomal protein DTO10_12335 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) DTO10_12340 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DTO10_12345 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DTO10_12360 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) DTO10_12365 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DTO10_12370 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) DTO10_12375 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DTO10_12380 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) DTO10_12385 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) DTO10_12390 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) DTO10_12395 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) DTO10_12400 ENOG41082SA 50s ribosomal protein l29 DTO10_12405 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal DTO10_12415 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) DTO10_12425 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DTO10_12430 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) DTO10_12435 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DTO10_12440 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) DTO10_12445 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DTO10_12450 ENOG4105VPB 50S ribosomal protein L30 DTO10_12460 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DTO10_12470 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) DTO10_12480 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits DTO10_12485 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DTO10_12490 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DTO10_12495 ENOG4108ZT0 50S ribosomal protein l17 DTO10_12500 ENOG4108JJB ABC transporter DTO10_12505 ENOG4108JJB ABC transporter DTO10_12510 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DTO10_12520 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DTO10_12525 ENOG4108UJD 30S ribosomal protein S9 DTO10_12535 ENOG4105C8I hydrolase, family 38 DTO10_12550 ENOG4105MU9 integral membrane protein DTO10_12560 ENOG4105C2F Histidine kinase DTO10_12565 ENOG4105EQD regulatoR DTO10_12575 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DTO10_12585 ENOG4105CS2 ec 3.2.1.21 DTO10_12590 ENOG4105DKQ ROK family DTO10_12595 ENOG41066F8 ROK family DTO10_12600 ENOG4105DG6 mannose-6-phosphate isomerase DTO10_12620 ENOG4105D1F ATP-binding protein DTO10_12635 ENOG4108NMV polysaccharide deacetylase DTO10_12715 ENOG4105EMN RNA polymerase sigma factor DTO10_12725 ENOG4105C8B TIGR00159 family DTO10_12730 ENOG4107U5W ybbr family DTO10_12735 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DTO10_12740 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DTO10_12745 ENOG4108ZMX Domain of unknown function (DU1801) DTO10_12750 ENOG4105CPF Cell wall formation (By similarity) DTO10_12760 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DTO10_12765 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DTO10_12795 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DTO10_12800 ENOG4105BZ8 glutamate synthase DTO10_12805 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) DTO10_12825 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR DTO10_12865 ENOG4105CBD Diacylglycerol kinase DTO10_12870 ENOG4107SUZ Sodium/hydrogen exchanger family DTO10_12880 ENOG4105C1Q protoporphyrinogen oxidase DTO10_12890 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DTO10_12895 ENOG4105F38 ABC transporter, permease DTO10_12900 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component DTO10_12905 ENOG4107RUE extracellular solute-binding protein family 1 DTO10_12910 ENOG41085KW ppic-type peptidyL-prolyl cis-trans isomerase DTO10_12920 ENOG4108SU4 UPF0309 protein DTO10_12925 ENOG4105FDP GntR family transcriptional regulator DTO10_12930 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) DTO10_12935 ENOG4105CE4 GlcNAc 6-P deacetylase DTO10_12940 ENOG4105CI1 PTS System DTO10_12950 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DTO10_12970 ENOG410650H (LipO)protein DTO10_12975 ENOG4105DBE peroxidase DTO10_12980 ENOG4107SJW iron permease, FTR1 DTO10_12995 ENOG4105C37 (CBS) domain DTO10_13000 ENOG4105BZU Histidine kinase DTO10_13005 ENOG4105BZU Histidine kinase DTO10_13010 ENOG4108MJI response regulator DTO10_13065 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DTO10_13115 ENOG4105CPF Cell wall formation (By similarity) DTO10_13120 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DTO10_13125 ENOG4108MJI response regulator DTO10_13130 ENOG4105C1J atp-dependent rna helicase DTO10_13135 ENOG410905X membrane-flanked domain protein DTO10_13140 ENOG4105CKV Membrane DTO10_13150 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DTO10_13155 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DTO10_13170 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DTO10_13175 ENOG4107MMM Anti-sigma-factor antagonist DTO10_13180 ENOG4105FUA antagonist DTO10_13185 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase DTO10_13190 ENOG4107SGM protein serine threonine phosphatase DTO10_13195 ENOG4105WN5 stage II sporulation protein DTO10_13200 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DTO10_13210 ENOG41064BQ Phosphatase DTO10_13225 ENOG410906U SprT-like DTO10_13305 ENOG4105K8N protein family UPF0079, ATPase DTO10_13310 ENOG41072GX Peptidase M22 Glycoprotease DTO10_13315 ENOG410801F ribosomal-protein-alanine acetyltransferase DTO10_13320 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DTO10_13325 ENOG4105C5H ABC transporter DTO10_13335 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) DTO10_13345 ENOG4108TYN CAAX amino terminal protease family protein DTO10_13355 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DTO10_13380 ENOG4105DEF Extracellular solute-binding protein, family 5 DTO10_13385 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DTO10_13390 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DTO10_13395 ENOG4105C3U ABC transporter DTO10_13400 ENOG4108JQ7 (ABC) transporter DTO10_13405 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DTO10_13415 ENOG4105DKQ ROK family DTO10_13420 ENOG4106N3A copper homeostasis protein cutc DTO10_13440 ENOG4105C19 ABC transporter DTO10_13455 ENOG4105CMG Carbohydrate kinase DTO10_13465 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DTO10_13475 ENOG4108XG2 Histidine kinase DTO10_13480 ENOG4105WH1 Two component transcriptional regulator luxr family DTO10_13485 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DTO10_13500 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DTO10_13505 ENOG4108UMI ABC transporter, permease DTO10_13520 ENOG4105DZ1 carboxypeptidase DTO10_13535 ENOG4105DYB Isoaspartyl dipeptidase DTO10_13555 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) DTO10_13560 ENOG4105C84 Histidine ammonia-lyase DTO10_13570 ENOG4105CI2 imidazolone-5-propionate hydrolase DTO10_13580 ENOG4108IJ7 Glycine betaine DTO10_13615 ENOG4105EC2 ftsk spoIIIe DTO10_13630 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) DTO10_13640 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DTO10_13655 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DTO10_13660 ENOG4105C7N Xanthine uracil vitamin C permease DTO10_13665 ENOG4105CID antiterminator DTO10_13710 ENOG4105FF2 Type I DHQase DTO10_13715 ENOG4105E2X shikimate dehydrogenase DTO10_13725 ENOG4105ETE Transcriptional regulator (LacI family DTO10_13730 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DTO10_13755 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DTO10_13760 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DTO10_13765 ENOG4105C83 adenylosuccinate lyase DTO10_13775 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DTO10_13780 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I DTO10_13785 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii DTO10_13800 ENOG4108V3E phosphoribosylglycinamide formyltransferase DTO10_13810 ENOG4105C12 Phosphoribosylglycinamide synthetase DTO10_13825 ENOG4108R5T secreted protein DTO10_13830 ENOG4105KGF protein, YerC YecD DTO10_13835 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) DTO10_13840 ENOG4105C4R Atp-dependent dna helicase DTO10_13845 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DTO10_13855 ENOG4105C26 Dehydrogenase DTO10_13860 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DTO10_13865 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DTO10_13870 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DTO10_13875 ENOG4105DU6 RNA polymerase DTO10_13895 ENOG4105CBD Diacylglycerol kinase DTO10_13900 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DTO10_13915 ENOG4108JYZ YitT family DTO10_13920 ENOG4108QY0 Membrane DTO10_13935 ENOG4105CZ3 stage V sporulation protein ad DTO10_13940 ENOG41090VF Stage v sporulation protein ac DTO10_13990 ENOG4105CDW Resistance protein DTO10_13995 ENOG41069NU Nitroreductase DTO10_14010 ENOG4105KTB nuclear export factor GLE1 DTO10_14015 ENOG4108T5E Copper resistance protein DTO10_14020 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DTO10_14030 ENOG4105BZU Histidine kinase DTO10_14035 ENOG4108N5C SNARE associated Golgi protein-related protein DTO10_14040 ENOG410807C QueT transporter DTO10_14045 ENOG4108UIN ybak prolyl-trna synthetase associated region DTO10_14065 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DTO10_14070 ENOG4105BZU Histidine kinase DTO10_14080 ENOG4105IIU Aminopeptidase DTO10_14115 ENOG4106BRA Membrane DTO10_14130 ENOG4105BZU Histidine kinase DTO10_14135 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) DTO10_14140 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DTO10_14150 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DTO10_14160 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DTO10_14185 ENOG4105FKQ transcriptional regulator DTO10_14200 ENOG4105CK5 oxidoreductase DTO10_14210 ENOG4105FE9 pseudouridine synthase DTO10_14225 ENOG4107SET aldo keto reductase DTO10_14245 ENOG4105C2J ABC transporter DTO10_14250 ENOG4105CNN ABC, transporter DTO10_14265 ENOG4105C0H protease DTO10_14275 ENOG4105E2S oxidase) subunit II DTO10_14285 ENOG4105CCU oxidase (Subunit III) DTO10_14310 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) DTO10_14315 ENOG4105CFH Aspartokinase DTO10_14320 ENOG4108SDH ABC, transporter DTO10_14330 ENOG4107Y03 Nitroreductase DTO10_14335 ENOG4105BZ1 (ABC) transporter DTO10_14340 ENOG4105BZ1 (ABC) transporter DTO10_14345 ENOG4105D22 carbon starvation protein DTO10_14350 ENOG4105VCD cytoplasmic protein DTO10_14355 ENOG4105BZU Histidine kinase DTO10_14370 ENOG4105DY9 regulatoR DTO10_14375 ENOG4105CYC Transferase DTO10_14380 ENOG4105C02 permease DTO10_14385 ENOG4105C26 Dehydrogenase DTO10_14390 ENOG4107QJT sodium dicarboxylate symporter DTO10_14395 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DTO10_14400 ENOG4105C5Y PTS System DTO10_14405 ENOG4105CG3 alpha amylase, catalytic region DTO10_14410 ENOG4107414 GntR family transcriptional regulator DTO10_14415 ENOG41069ER domain protein DTO10_14420 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DTO10_14425 ENOG4107KM7 Heat induced stress protein YflT DTO10_14440 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family DTO10_14445 ENOG4107XGZ Hydrolase DTO10_14460 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase DTO10_14465 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DTO10_14470 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DTO10_14480 ENOG4105C26 Dehydrogenase DTO10_14485 ENOG4108J2R molybdopterin oxidoreductase DTO10_14490 ENOG4105CK7 Sodium proline symporter DTO10_14495 ENOG4105BZU Histidine kinase DTO10_14500 ENOG4105FDU atp-dependent rna helicase DTO10_14510 ENOG4108594 Permease of the drug metabolite transporter DTO10_14515 ENOG4105C28 cystathionine DTO10_14525 ENOG4108R6K riboflavin synthase, subunit alpha DTO10_14530 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DTO10_14545 ENOG4107U9T Pfam:Ribonuclease_BN DTO10_14555 ENOG4107S91 Sodium hydrogen exchanger DTO10_14560 ENOG4105NCW Trka-c domain protein DTO10_14575 ENOG4108KK1 membrane protein AbrB duplication DTO10_14580 ENOG4105E14 MotA TolQ exbB proton channel DTO10_14585 ENOG4105ER2 Ompa motb domain protein DTO10_14595 ENOG4107RKG DJ-1/PfpI family DTO10_14600 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DTO10_14610 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b DTO10_14615 ENOG4105CVM Molybdenum cofactor synthesis domain protein DTO10_14620 ENOG41068PA UPF0435 protein DTO10_14630 ENOG4107U9T Pfam:Ribonuclease_BN DTO10_14635 ENOG4105C59 p-type ATPase DTO10_14640 ENOG4108ISG Major Facilitator DTO10_14645 ENOG4105UPD Calcium Proton DTO10_14685 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DTO10_14690 ENOG4108W15 Protein of unknown function (DUF1456) DTO10_14695 ENOG4107R0W ABC transporter DTO10_14700 ENOG4105E5Q amino acid AbC transporter DTO10_14705 ENOG4105CDA abc transporter atp-binding protein DTO10_14725 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DTO10_14730 ENOG4108I5D sulfate abc transporter DTO10_14735 ENOG4106IQC argininosuccinate lyase DTO10_14745 ENOG4105E1V na solute symporter DTO10_14755 ENOG4105C85 amino acid DTO10_14770 ENOG4107QTZ amino acid DTO10_14820 ENOG4105DA5 (ABC) transporter DTO10_14850 ENOG4106V2I dimethylaminohydrolase DTO10_14855 ENOG4108IQI permease DTO10_14910 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DTO10_14925 ENOG4105CDA abc transporter atp-binding protein DTO10_14930 ENOG4105DRP amino acid AbC transporter DTO10_14945 ENOG4105ECP epimerase DTO10_14950 ENOG4105CHM Aminotransferase DTO10_14995 ENOG4105K7K Transcriptional regulator DTO10_15020 ENOG4105CZM Major Facilitator DTO10_15045 ENOG4106F5Q Membrane DTO10_15050 ENOG4106PMH Extracellular solute-binding protein family 3 DTO10_15055 ENOG4105E5Q amino acid AbC transporter DTO10_15070 ENOG4105CMU LysR family (Transcriptional regulator DTO10_15090 ENOG4105C1G acyl-Coa dehydrogenase DTO10_15095 ENOG4105CHU acetyl-coa acetyltransferase DTO10_15115 ENOG4105ECP epimerase DTO10_15120 ENOG410902V Modulates RecA activity (By similarity) DTO10_15130 ENOG4105XHU Acid-soluble spore protein K DTO10_15140 ENOG41067AE Membrane-bound metal-dependent hydrolase DTO10_15145 ENOG4105CEN a g-specific adenine glycosylase DTO10_15155 ENOG4106BXE DTO10_15160 ENOG4105CAN Short-chain dehydrogenase reductase Sdr DTO10_15175 ENOG4105EVI UPF0374 protein DTO10_15180 ENOG4105BZ1 (ABC) transporter DTO10_15195 ENOG4105CS1 NAD(P)H quinone oxidoreductase DTO10_15200 ENOG4105C0R drug resistance transporter emrb qaca subfamily DTO10_15205 ENOG4105CW7 secretion protein, HlyD family DTO10_15210 ENOG41067TZ transcriptional regulator, MarR family DTO10_15215 ENOG4107NBY Membrane DTO10_15220 ENOG4105CBC glutamate synthase DTO10_15225 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DTO10_15235 ENOG4108IUW ABC transporter DTO10_15250 ENOG4108S4H thioesterase Superfamily protein DTO10_15255 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DTO10_15265 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DTO10_15285 ENOG4105G5W regulator Fur family DTO10_15290 ENOG4105TUA UPF0295 protein DTO10_15390 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DTO10_15570 ENOG4105CSV Glutaminase DTO10_15590 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DTO10_15595 ENOG4105C0R drug resistance transporter emrb qaca subfamily DTO10_15605 ENOG4105GVF (ABC) transporter DTO10_15615 ENOG4105BZU Histidine kinase DTO10_15620 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DTO10_15640 ENOG4105U0R haloacid dehalogenase-like hydrolase DTO10_15645 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) DTO10_15675 ENOG41090UD (LipO)protein DTO10_15680 ENOG4107NBY Membrane DTO10_15710 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DTO10_15745 ENOG4105ERH Fumarylacetoacetate hydrolase DTO10_15755 ENOG4105VRR gCN5-related N-acetyltransferase DTO10_15765 ENOG4105NAE bifunctional deaminase-reductase domain protein DTO10_15775 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) DTO10_15790 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) DTO10_15810 ENOG41083I7 UPF0145 protein DTO10_15835 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) DTO10_15840 ENOG4105BZC d-serine deaminase DTO10_15850 ENOG4108VKI Cell wall hydrolase DTO10_15900 ENOG410645S MarR family Transcriptional regulator DTO10_15915 ENOG4108Q5Y Membrane DTO10_15920 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DTO10_15930 ENOG4105C9Q fumarate hydratase class II DTO10_15935 ENOG4105E1K spore germination protein DTO10_15940 ENOG4108Q5U germination protein, ger(x)c family DTO10_15950 ENOG4108Q8B Spore germination protein DTO10_15955 ENOG4108Q8B Spore germination protein DTO10_15970 ENOG4105CY2 Citrate transporter DTO10_15975 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DTO10_15980 ENOG4105C26 Dehydrogenase DTO10_15985 ENOG4105DRR Transcriptional regulator, GntR family DTO10_15990 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DTO10_16005 ENOG4105C6Z Gluconate DTO10_16015 ENOG4108JUB Transcriptional regulator DTO10_16030 ENOG4105DVW rieske (2Fe-2S) DTO10_16040 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DTO10_16045 ENOG4105C94 Transporter DTO10_16050 ENOG4105PAD Hydrolase DTO10_16055 ENOG4108JUB Transcriptional regulator DTO10_16075 ENOG4108JQ1 Dehydrogenase DTO10_16095 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DTO10_16100 ENOG4105E7W lamb ycsf family protein DTO10_16105 ENOG4108JUB Transcriptional regulator DTO10_16120 ENOG4105J7D transcriptional regulator DTO10_16125 ENOG4105C0R drug resistance transporter emrb qaca subfamily DTO10_16135 ENOG4108ZHR arsR family transcriptional regulator DTO10_16150 ENOG4105T38 integral membrane protein DTO10_16185 ENOG4107ZTW SNARE associated Golgi DTO10_16195 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B DTO10_16205 ENOG4105CFC Transporter DTO10_16235 ENOG41068WN DTO10_16240 ENOG4105N14 lysine exporter protein LysE YggA DTO10_16270 ENOG4106CAD Protein of unknown function (DUF3311) DTO10_16275 ENOG4105E1V na solute symporter DTO10_16285 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DTO10_16290 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DTO10_16300 ENOG4108HGU Histidine kinase DTO10_16305 ENOG4105CS2 ec 3.2.1.21 DTO10_16310 ENOG4108S3Y transcriptional regulator DTO10_16315 ENOG4108HH4 Major Facilitator Superfamily DTO10_16335 ENOG4107E54 Small Multidrug Resistance protein DTO10_16340 ENOG4107E54 Small Multidrug Resistance protein DTO10_16350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DTO10_16355 ENOG4105BZ1 (ABC) transporter DTO10_16360 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DTO10_16365 ENOG4105ME7 Membrane DTO10_16385 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DTO10_16395 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DTO10_16400 ENOG4108DBC nitroreductase DTO10_16405 ENOG4105E0A ABC, transporter DTO10_16415 ENOG4105DQ5 transport system permease protein DTO10_16420 ENOG4105EHG Permease protein DTO10_16440 ENOG4107QTZ amino acid DTO10_16450 ENOG4105CYN Serine protein kinase DTO10_16470 ENOG4106AKX UPF0229 protein DTO10_16490 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DTO10_16575 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DTO10_16615 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) DTO10_16645 ENOG4105C9A Phoh family DTO10_16655 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DTO10_16810 ENOG4108WZM domain protein DTO10_16815 ENOG41069ER domain protein DTO10_16825 ENOG4105MFU Protein of unknown function (DUF2634) DTO10_16830 ENOG41066EA baseplate J family protein DTO10_16910 ENOG4107QZI cell division protein FtsK DTO10_16940 ENOG4105DJ2 Major Facilitator Superfamily DTO10_16945 ENOG41073TP transcriptional regulator DTO10_16990 ENOG4105C0X amino acid DTO10_16995 ENOG4105CSC Glucose uptake protein DTO10_17000 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DTO10_17010 ENOG4105FBW Monooxygenase DTO10_17015 ENOG4107T8P acyl-Coa dehydrogenase DTO10_17030 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) DTO10_17045 ENOG4105XRQ Xanthine dehydrogenase accessory factor DTO10_17050 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase DTO10_17055 ENOG4108VX5 3-methyladenine DNA glycosylase DTO10_17060 ENOG4105C0R drug resistance transporter emrb qaca subfamily DTO10_17065 ENOG4105II7 pyrroline-5-carboxylate reductase DTO10_17070 ENOG4105CQB FAD linked oxidase domain protein DTO10_17080 ENOG4105DCF alanine dehydrogenase DTO10_17085 ENOG4105EU9 DTO10_17090 ENOG4108K8K Transcriptional regulator DTO10_17095 ENOG4105CJ3 phosphate transporter DTO10_17100 ENOG4107GRR phosphate transport regulator DTO10_17105 ENOG4105CJ3 phosphate transporter DTO10_17115 ENOG4107BMA Transglycosylase associated protein DTO10_17120 ENOG4108YBP pseudouridine synthase DTO10_17140 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DTO10_17175 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DTO10_17195 ENOG4105DTQ mandelate racemase muconate lactonizing DTO10_17200 ENOG4108K88 Membrane DTO10_17205 ENOG4105ED1 spovr family DTO10_17210 ENOG4105KAC Antibiotic biosynthesis monooxygenase DTO10_17215 ENOG4105EFZ amidohydrolase DTO10_17235 ENOG4105JAB phenazine biosynthesis protein, phzf family DTO10_17240 ENOG4107U9B transcriptional regulator DTO10_17290 ENOG4105VMP Transcriptional regulator DTO10_17305 ENOG41082YX Transcriptional regulator, arsr family DTO10_17310 ENOG4107R5R arsenical pump membrane protein DTO10_17315 ENOG4108UXE Protein tyrosine phosphatase DTO10_17320 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DTO10_17325 ENOG4106YBV Methyl-accepting chemotaxis DTO10_17330 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DTO10_17340 ENOG41080BT SNARE associated Golgi DTO10_17345 ENOG4105EFI regulatoR DTO10_17350 ENOG4105BZU Histidine kinase DTO10_17360 ENOG4105FGV Chromate DTO10_17365 ENOG4105CAH Chromate DTO10_17375 ENOG4105C5R Aminotransferase DTO10_17380 ENOG4105CD3 dihydroorotase DTO10_17400 ENOG4105DZS Phenylacetate-CoA ligase DTO10_17405 ENOG4105CAY ferredoxin--nadp reductase DTO10_17415 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit DTO10_17440 ENOG4105E39 Enoyl-CoA hydratase DTO10_17445 ENOG4105CGU Enoyl-CoA hydratase DTO10_17450 ENOG4105C26 Dehydrogenase DTO10_17455 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DTO10_17460 ENOG4105CHU acetyl-coa acetyltransferase DTO10_17465 ENOG4105E39 Enoyl-CoA hydratase DTO10_17470 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein DTO10_17475 ENOG4108Z0R Transferase DTO10_17495 ENOG4105PGM cation diffusion facilitator family transporter DTO10_17500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DTO10_17505 ENOG4105BZU Histidine kinase DTO10_17510 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) DTO10_17520 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) DTO10_17530 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) DTO10_17540 ENOG4105E0C molybdate abc transporter DTO10_17560 ENOG4105VEQ Cold shock protein DTO10_17570 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DTO10_17575 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DTO10_17580 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase DTO10_17585 ENOG4105CHH sulfate transporter DTO10_17600 ENOG4105C1G acyl-Coa dehydrogenase DTO10_17605 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DTO10_17610 ENOG4105E39 Enoyl-CoA hydratase DTO10_17615 ENOG4105CHU acetyl-coa acetyltransferase DTO10_17620 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_17630 ENOG4105CSP Major Facilitator Superfamily DTO10_17655 ENOG4105D4T Citrate transporter DTO10_17675 ENOG4108W0I acetyltransferase DTO10_17685 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DTO10_17700 ENOG4108REF Sporulation integral membrane protein ytvi DTO10_17705 ENOG4105C37 (CBS) domain DTO10_17710 ENOG4108JYZ YitT family DTO10_17720 ENOG4107T5V SNARE associated Golgi DTO10_17725 ENOG4105C37 (CBS) domain DTO10_17730 ENOG4105BZU Histidine kinase DTO10_17745 ENOG4105BZ4 penicillin-binding protein DTO10_17755 ENOG4105DYB Isoaspartyl dipeptidase DTO10_17765 ENOG4105CPP Dehydrogenase, E1 component DTO10_17770 ENOG4105C7S Dehydrogenase DTO10_17785 ENOG4105CIH Imidazole acetol-phosphate transaminase DTO10_17815 ENOG4105JQZ Methyltransferase DTO10_17820 ENOG4108DMH HTH_ARAC DTO10_17880 ENOG4107VGR Catalase DTO10_17895 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DTO10_17910 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DTO10_17915 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DTO10_17920 ENOG4107RF6 penicillin-binding protein DTO10_17935 ENOG4105BZ1 (ABC) transporter DTO10_17940 ENOG4105BZ1 (ABC) transporter DTO10_17945 ENOG4105NRA 50s ribosomal protein l31 type b DTO10_17950 ENOG4105C28 cystathionine DTO10_17955 ENOG4105C28 cystathionine DTO10_17960 ENOG4105C9Q fumarate hydratase class II DTO10_17985 ENOG4105F1J Homogentisate 1,2-dioxygenase DTO10_18000 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DTO10_18010 ENOG4105D01 (LipO)protein DTO10_18015 ENOG4108UMI ABC transporter, permease DTO10_18020 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DTO10_18030 ENOG4105C6Y Udp-glucose 6-dehydrogenase DTO10_18055 ENOG4105C3Q Glycosyl transferase, family 2 DTO10_18065 ENOG4105EKT )-iron permease DTO10_18085 ENOG410839P DTO10_18090 ENOG410839P DTO10_18100 ENOG410839P DTO10_18110 ENOG4105WZB UPF0342 protein DTO10_18140 ENOG4105KI2 Urea amidohydrolase subunit beta DTO10_18165 ENOG4107TUM Amidinotransferase DTO10_18170 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_18175 ENOG4105CGU Enoyl-CoA hydratase DTO10_18185 ENOG4105D7V transposase DTO10_18190 ENOG4105C6T cysteine synthase DTO10_18195 ENOG4107VRP DNA repair exonuclease DTO10_18200 ENOG4106D4I domain protein DTO10_18215 ENOG4105E0A ABC, transporter DTO10_18225 ENOG4105EQI Metal Dependent Phosphohydrolase DTO10_18235 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DTO10_18265 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) DTO10_18280 ENOG4105NBU tryptophan transport protein DTO10_18285 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DTO10_18290 ENOG4105K59 histidine triad (HIT) protein DTO10_18315 ENOG410841Q phosphoesterase PA-phosphatase related protein DTO10_18320 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DTO10_18325 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DTO10_18330 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DTO10_18340 ENOG4106AXD DTO10_18345 ENOG4108RQ5 Beta-lactamase domain-containing protein DTO10_18350 ENOG4105DF9 Lipoate-protein, ligase DTO10_18355 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_18370 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DTO10_18375 ENOG4107AYK membrAne DTO10_18385 ENOG4105XVF Competence transcription factor DTO10_18395 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 DTO10_18400 ENOG41060YP DTO10_18460 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_18475 ENOG4105YHS UPF0344 protein DTO10_18485 ENOG4105CAQ asparagine synthetase DTO10_18495 ENOG4107FKK extracellular solute-binding protein family 1 DTO10_18510 ENOG4105FKQ transcriptional regulator DTO10_18520 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DTO10_18525 ENOG4108VPT UPF0234 protein DTO10_18535 ENOG4105EPR degv family DTO10_18540 ENOG4107AYK membrAne DTO10_18545 ENOG4105QVS general stress protein DTO10_18550 ENOG41073B9 DTO10_18555 ENOG4108KP7 hydrolase DTO10_18560 ENOG4108MXZ Esterase DTO10_18565 ENOG4105VG1 fes assembly suf system protein DTO10_18570 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DTO10_18575 ENOG4107V6Q Cyclic nucleotide-binding domain DTO10_18580 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase DTO10_18585 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DTO10_18590 ENOG4105CAS nag kinase DTO10_18600 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DTO10_18610 ENOG4105DBV ornithine carbamoyltransferase DTO10_18625 ENOG4105ERH Fumarylacetoacetate hydrolase DTO10_18640 ENOG4105MSY salicylate hydroxylase DTO10_18645 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DTO10_18675 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DTO10_18680 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DTO10_18690 ENOG4108KU1 UPF0736 protein DTO10_18695 ENOG4105C31 Tryptophanyl-tRNA synthetase DTO10_18715 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) DTO10_18720 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis DTO10_18725 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DTO10_18735 ENOG4105DPN Oligoendopeptidase f DTO10_18745 ENOG4105T58 Dithiol-disulfide isomerase DTO10_18750 ENOG4108Z18 K06886 hemoglobin DTO10_18755 ENOG4105E4C Lytic transglycosylase catalytic DTO10_18760 ENOG4105MIX Adenylate cyclase DTO10_18770 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DTO10_18775 ENOG4105EMS pseudouridine synthase DTO10_18785 ENOG4105CJW magnesium transporter DTO10_18790 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DTO10_18830 ENOG41090VF Stage v sporulation protein ac DTO10_18835 ENOG4105CZ3 stage V sporulation protein ad DTO10_18855 ENOG4105ENA helicase DTO10_18875 ENOG4108ZMI UPF0477 protein DTO10_18885 ENOG4108W5N phosphatidylglycerophosphatase a DTO10_18900 ENOG4108Z0Z intracellular protease Pfpi family DTO10_18925 ENOG4105SFS phosphoesterase RecJ domain protein DTO10_18930 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DTO10_18935 ENOG4105C1G acyl-Coa dehydrogenase DTO10_18960 ENOG41069FQ Metallo-beta-lactamase superfamily DTO10_18965 ENOG4105C5I Dehydrogenase DTO10_18975 ENOG4105D7V transposase DTO10_18980 ENOG4105C2C drug resistance transporter, Bcr CflA DTO10_18985 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr DTO10_18990 ENOG4105EE0 oxidoreductase DTO10_19000 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DTO10_19005 ENOG4105EBR Carboxylesterase DTO10_19010 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) DTO10_19015 ENOG4105C85 amino acid DTO10_19020 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) DTO10_19025 ENOG4106IPI cyclase, family DTO10_19030 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) DTO10_19035 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DTO10_19040 ENOG4108I5D sulfate abc transporter DTO10_19055 ENOG4105CJW magnesium transporter DTO10_19070 ENOG4107YBY Hydrolase DTO10_19075 ENOG41067SE Tetr family transcriptional regulator DTO10_19080 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DTO10_19085 ENOG4105Z8B NlpC/P60 family DTO10_19100 ENOG4108N2V aldose 1-epimerase DTO10_19105 ENOG4105D5Q Arginine ornithine antiporter DTO10_19125 ENOG4105VEQ Cold shock protein DTO10_19140 ENOG4105C26 Dehydrogenase DTO10_19145 ENOG41079KZ Major Facilitator Superfamily DTO10_19150 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DTO10_19155 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase DTO10_19160 ENOG4105DWF phosphomethylpyrimidine kinase DTO10_19170 ENOG4105ETU transcriptional activator (TenA DTO10_19185 ENOG4107TCE N-acetyltransferase DTO10_19195 ENOG4105BZ1 (ABC) transporter DTO10_19200 ENOG4106DF1 DTO10_19210 ENOG4108S4H thioesterase Superfamily protein DTO10_19215 ENOG4106I4J membrane DTO10_19225 ENOG4108JQ7 (ABC) transporter DTO10_19230 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DTO10_19235 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DTO10_19245 ENOG4105DER m42 family DTO10_19250 ENOG410606W general stress protein DTO10_19285 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DTO10_19300 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DTO10_19305 ENOG4105DVE abc transporter atp-binding protein DTO10_19325 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) DTO10_19330 ENOG4105DFD Na H antiporter DTO10_19335 ENOG4105CNI cell division protein FtsW DTO10_19350 ENOG4107TS3 membrane protein, TerC DTO10_19355 ENOG4108WZW RNA polymerase sigma DTO10_19375 ENOG4105BZU Histidine kinase DTO10_19380 ENOG4105C1G acyl-Coa dehydrogenase DTO10_19385 ENOG4105CHR reductase DTO10_19390 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_19395 ENOG4108IG5 Transcriptional regulator DTO10_19400 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DTO10_19405 ENOG4105E39 Enoyl-CoA hydratase DTO10_19425 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DTO10_19430 ENOG4105CGU Enoyl-CoA hydratase DTO10_19435 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DTO10_19450 ENOG4108TGC Acyltransferase DTO10_19455 ENOG4105BZU Histidine kinase DTO10_19470 ENOG4105EU0 Major facilitator Superfamily DTO10_19475 ENOG4105BZU Histidine kinase DTO10_19480 ENOG41090MY MarR family Transcriptional regulator DTO10_19490 ENOG4108K88 Membrane DTO10_19520 ENOG4107Y9E nuclease DTO10_19535 ENOG4105KRI phosphocarrier protein (HPr DTO10_19540 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DTO10_19545 ENOG4105CHR reductase DTO10_19550 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DTO10_19560 ENOG4105CHM Aminotransferase DTO10_19565 ENOG4105D7N magnesium and cobalt transport protein CorA DTO10_19570 ENOG41085PJ rdd domain containing protein DTO10_19575 ENOG4107R88 Chemotaxis protein (CheV) DTO10_19580 ENOG4105UIN DTO10_19605 ENOG4107QWE )-transporter DTO10_19610 ENOG4105EPM Diguanylate phosphodiesterase DTO10_19635 ENOG4107IN1 Protein of unknown function (DUF1797) DTO10_19645 ENOG4105C0R drug resistance transporter emrb qaca subfamily DTO10_19655 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) DTO10_19660 ENOG4105CH2 amidohydrolase DTO10_19665 ENOG4107ZYR domain protein DTO10_19670 ENOG4105CN5 Metallo-Beta-Lactamase DTO10_19685 ENOG4108X4Q Hydrolase DTO10_19710 ENOG4105CPP Dehydrogenase, E1 component DTO10_19715 ENOG4105C7S Dehydrogenase DTO10_19730 ENOG4108ZJ4 polysaccharide deacetylase DTO10_19760 ENOG4105CXN decarboxylase DTO10_19765 ENOG4105EA8 2-Nitropropane dioxygenase DTO10_19770 ENOG4105WBI UPF0223 protein DTO10_19775 ENOG4105CRQ synthase (Component I) DTO10_19780 ENOG4105DDQ anthranilate synthase DTO10_19820 ENOG4105ECY inositol monophosphatase DTO10_19830 ENOG4105CI3 gtp-binding protein typa DTO10_19835 ENOG4105QA2 DTO10_19860 ENOG4108IAB Phoh family DTO10_19875 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DTO10_19880 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) DTO10_19885 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DTO10_19925 ENOG4106UY4 Inherit from COG: Scp-like extracellular DTO10_19970 ENOG4106H78 methyltransferase DTO10_19975 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) DTO10_19980 ENOG4105H20 Sporulation integral membrane protein YlbJ DTO10_19985 ENOG4105D78 K07001 NTE family protein DTO10_19990 ENOG41063PX domain protein DTO10_19995 ENOG4105CDE UPF0348 protein DTO10_20000 ENOG4105KNH Nucleic acid-binding protein DTO10_20010 ENOG4105E39 Enoyl-CoA hydratase DTO10_20035 ENOG41074B2 UPF0747 protein DTO10_20040 ENOG4108V6E Cell division protein mraZ DTO10_20045 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) DTO10_20055 ENOG4105CJN penicillin-binding protein DTO10_20060 ENOG4105CJN penicillin-binding protein DTO10_20065 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DTO10_20070 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) DTO10_20075 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DTO10_20080 ENOG4105CNI cell division protein FtsW DTO10_20085 ENOG4105D4A Cell wall formation (By similarity) DTO10_20090 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) DTO10_20095 ENOG4108R2U division initiation protein DTO10_20105 ENOG4105K67 small basic protein DTO10_20110 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DTO10_20115 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DTO10_20120 ENOG4108AWX Sporulation factor SpoIIGA DTO10_20125 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DTO10_20135 ENOG4105WR5 sporulation protein, YlmC YmxH family DTO10_20140 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DTO10_20145 ENOG4105DFA alanine racemase domain protein DTO10_20150 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) DTO10_20155 ENOG41067XK integral membrane protein DTO10_20160 ENOG4105DBK s4 domain protein DTO10_20175 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) DTO10_20180 ENOG4105C34 Pseudouridine synthase DTO10_20185 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) DTO10_20195 ENOG4105CXT aspartate transcarbamylase DTO10_20210 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DTO10_20215 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DTO10_20220 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) DTO10_20230 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DTO10_20235 ENOG4105F23 Fibronectin-binding protein DTO10_20245 ENOG4105DSJ YicC domain protein DTO10_20255 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DTO10_20265 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DTO10_20270 ENOG4105C25 Primosomal protein n' DTO10_20280 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) DTO10_20285 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DTO10_20290 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DTO10_20295 ENOG4108ZF3 Phosphatase DTO10_20300 ENOG4105D9P serine threonine protein kinase DTO10_20305 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DTO10_20310 ENOG4105DJV ribulose-phosphate 3-epimerase DTO10_20315 ENOG4105FJ0 thiamine DTO10_20325 ENOG4105VB9 50S ribosomal protein l28 DTO10_20330 ENOG4108ZAA Alkaline-shock protein DTO10_20335 ENOG4105DP4 dak2 domain fusion protein ylov DTO10_20345 ENOG4105EJQ L-serine dehydratase DTO10_20350 ENOG4105CB5 ATP-dependent DNA helicase recG DTO10_20355 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) DTO10_20365 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DTO10_20370 ENOG4105CHR reductase DTO10_20375 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DTO10_20380 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DTO10_20385 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DTO10_20390 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DTO10_20400 ENOG4105CJ1 ABC, transporter DTO10_20415 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DTO10_20445 ENOG4105K5M 30s ribosomal protein S16 DTO10_20450 ENOG4105VB6 UPF0109 protein DTO10_20460 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DTO10_20465 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DTO10_20470 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DTO10_20480 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DTO10_20485 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DTO10_20510 ENOG4105D00 flagellar biosynthetic protein flhB DTO10_20520 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DTO10_20525 ENOG4105C79 DNA protecting protein DprA DTO10_20530 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DTO10_20535 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) DTO10_20540 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DTO10_20550 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) DTO10_20555 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) DTO10_20560 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DTO10_20565 ENOG4108ZC9 flagellar basal-body rod protein flgc DTO10_20570 ENOG4105VQ0 flagellar hook-basal body complex protein fliE DTO10_20575 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) DTO10_20580 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DTO10_20595 ENOG4106YF4 Flagellar biosynthesis chaperone DTO10_20610 ENOG410822I Flagellar hook capping protein DTO10_20620 ENOG4105BZE flagellar hook protein, FlgE DTO10_20625 ENOG41068WV flagellar FlbD family protein DTO10_20635 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DTO10_20640 ENOG4105DD5 Flagellar motor switch protein DTO10_20645 ENOG4107YTP response regulator receiver protein DTO10_20655 ENOG4105CN7 Flagellar biosynthetic protein FliP DTO10_20660 ENOG4105VS8 Flagellar biosynthetic protein fliq DTO10_20665 ENOG4105D19 Role in flagellar biosynthesis (By similarity) DTO10_20670 ENOG4105D00 flagellar biosynthetic protein flhB DTO10_20675 ENOG4105D7B Flagellar biosynthesis protein flha DTO10_20680 ENOG4105FZW flagellar biosynthesis regulator FlhF DTO10_20690 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DTO10_20695 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DTO10_20700 ENOG4105CBS Chea signal transduction histidine kinase DTO10_20705 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis DTO10_20715 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) DTO10_20720 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DTO10_20735 ENOG4105CE9 30S ribosomal protein S2 DTO10_20755 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DTO10_20760 ENOG4105KNE Phosphatidate cytidylyltransferase DTO10_20765 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DTO10_20770 ENOG4105DZP Membrane-associated zinc metalloprotease DTO10_20780 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DTO10_20785 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) DTO10_20790 ENOG4105CHV Transcription elongation factor NusA DTO10_20795 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DTO10_20800 ENOG4105VHM ribosomal protein DTO10_20805 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DTO10_20810 ENOG4105W7A Protein of unknown function (DUF503) DTO10_20815 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DTO10_20820 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DTO10_20825 ENOG4105DTN riboflavin biosynthesis protein ribF DTO10_20830 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) DTO10_20835 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DTO10_20845 ENOG4105C1V Peptidase, M16 DTO10_20855 ENOG4105E35 Dipicolinate synthase subunit A DTO10_20860 ENOG4108S0H Dipicolinic acid synthetase, b subunit DTO10_20865 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DTO10_20875 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DTO10_20885 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DTO10_20895 ENOG4105CNU cell division protein FtsK DTO10_20905 ENOG4105FDP GntR family transcriptional regulator DTO10_20910 ENOG4105DIH basic membrane DTO10_20915 ENOG4108JQ9 ABC transporter DTO10_20920 ENOG4105UIB (ABC) transporter DTO10_20940 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DTO10_20945 ENOG4105XZV Protein of unknown function (DUF3243) DTO10_20960 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DTO10_20965 ENOG4105CEV competence damage-inducible protein DTO10_20980 ENOG4105D48 metallophosphoesterase DTO10_20985 ENOG4105MCT stage V sporulation protein S DTO10_20995 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DTO10_21000 ENOG4105DQU oxidoreductase, subunit beta DTO10_21010 ENOG4105CPQ Dehydrogenase DTO10_21015 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DTO10_21030 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) DTO10_21035 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DTO10_21040 ENOG4105VTR Integrase DTO10_21045 ENOG410635T phage-like element pbsx protein DTO10_21080 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DTO10_21085 ENOG4105VTR Integrase DTO10_21095 ENOG4107STQ Multicopper oxidase DTO10_21105 ENOG4105EPD Oligopeptide transporter, Opt family DTO10_21115 ENOG4105CHR reductase DTO10_21125 ENOG4105FCD Major Facilitator DTO10_21130 ENOG4108X79 transcriptional regulator DTO10_21135 ENOG4105VZJ PTS System DTO10_21140 ENOG4105CK1 PTS System DTO10_21145 ENOG4105VCP PTS System DTO10_21150 ENOG4105F8D glycoside hydrolase family 4 DTO10_21170 ENOG4105EE1 crotonyl-CoA reductase DTO10_21180 ENOG4108JCI Transcriptional regulator DTO10_21185 ENOG4108UMN azlc family DTO10_21205 ENOG4105EWM Histidine kinase DTO10_21210 ENOG4105C19 ABC transporter DTO10_21230 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DTO10_21235 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DTO10_21240 ENOG4106F1P AAA ATPase, central domain protein DTO10_21245 ENOG4105EN6 Membrane DTO10_21250 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DTO10_21255 ENOG4105CXI aluminum resistance protein DTO10_21260 ENOG4105KV4 Transcriptional regulator DTO10_21265 ENOG4105C5F glutamine synthetase DTO10_21405 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DTO10_21460 ENOG410900G Protein of unknown function (DUF421) DTO10_21510 ENOG4105D7V transposase DTO10_21520 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DTO10_21640 ENOG4107ZXU DSBA oxidoreductase DTO10_21645 ENOG4108TVJ Nitroreductase DTO10_21650 ENOG4105FQP Beta-lactamase DTO10_21675 ENOG41088SP formiminoglutamate hydrolase DTO10_21680 ENOG4105DND Transcriptional regulator DTO10_21705 ENOG41073R8 VanW family DTO10_21720 ENOG4105CK7 Sodium proline symporter DTO10_21775 ENOG4105C7K acetolactate synthase DTO10_21790 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DTO10_21815 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DTO10_21825 ENOG4108I5G Major Facilitator superfamily DTO10_21835 ENOG4105C28 cystathionine DTO10_21850 ENOG4108JUA Transcriptional regulator DTO10_21860 ENOG4105DRP amino acid AbC transporter DTO10_21865 ENOG4105CDA abc transporter atp-binding protein DTO10_21870 ENOG4105C87 Aminotransferase class I and II DTO10_21885 ENOG4105DFD Na H antiporter DTO10_21920 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DTO10_21925 ENOG41067Z0 domain protein DTO10_21930 ENOG4108SVB resolvase DTO10_21935 ENOG4105VPS UPF0291 protein DTO10_21955 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) DTO10_21965 ENOG4105C5I Dehydrogenase DTO10_21985 ENOG4105K63 Thioredoxin DTO10_21990 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DTO10_21995 ENOG41088CQ domain protein DTO10_22005 ENOG4108VGI doxx family DTO10_22010 ENOG4108ZJ4 polysaccharide deacetylase DTO10_22020 ENOG4107QIV Cytochrome c biogenesis protein DTO10_22025 ENOG4107YTP response regulator receiver protein DTO10_22050 ENOG4105EYH Exonuclease DTO10_22065 ENOG4106V2I dimethylaminohydrolase DTO10_22085 ENOG41060WC Enoyl-CoA hydratase DTO10_22100 ENOG4105E39 Enoyl-CoA hydratase DTO10_22115 ENOG4105VG1 fes assembly suf system protein DTO10_22130 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DTO10_22135 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DTO10_22140 ENOG4105C26 Dehydrogenase DTO10_22160 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_22170 ENOG4105CHU acetyl-coa acetyltransferase DTO10_22175 ENOG4105C1G acyl-Coa dehydrogenase DTO10_22180 ENOG4105CHU acetyl-coa acetyltransferase DTO10_22190 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_22220 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase DTO10_22225 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid DTO10_22270 ENOG4105EFZ amidohydrolase DTO10_22280 ENOG4107HP6 Transcriptional regulator DTO10_22285 ENOG4107HP6 Transcriptional regulator DTO10_22290 ENOG4105D6N CoA-transferase, subunit a DTO10_22295 ENOG4108IIH CoA-transferase subunit B DTO10_22300 ENOG4105CHU acetyl-coa acetyltransferase DTO10_22325 ENOG4107HP6 Transcriptional regulator DTO10_22335 ENOG4105WGP Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis (By similarity) DTO10_22340 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DTO10_22345 ENOG4105DZS Phenylacetate-CoA ligase DTO10_22380 ENOG4105CH2 amidohydrolase DTO10_22405 ENOG410751J DTO10_22410 ENOG4105KNA -acetyltransferase DTO10_22425 ENOG4105CHR reductase DTO10_22435 ENOG4105C84 Histidine ammonia-lyase DTO10_22440 ENOG4108IQI permease DTO10_22445 ENOG4105CRN Aminoglycoside phosphotransferase DTO10_22505 ENOG4105YWU small acid-soluble spore protein DTO10_22525 ENOG4105E8G Major facilitator Superfamily DTO10_22530 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DTO10_22535 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) DTO10_22550 ENOG4108IY8 ABC, transporter DTO10_22555 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DTO10_22560 ENOG4106FTQ Taurine ABC transporter, periplasmic DTO10_22580 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase DTO10_22585 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein DTO10_22590 ENOG4108VP3 Lysine exporter protein (LysE YggA) DTO10_22605 ENOG41087PP glycosyltransferase MGT family DTO10_22620 ENOG4105RHY Pfam:UPF0157 DTO10_22645 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DTO10_22650 ENOG4105CQB FAD linked oxidase domain protein DTO10_22655 ENOG4105JXH GntR family transcriptional regulator DTO10_22680 ENOG4108RWP Major Facilitator Superfamily protein DTO10_22695 ENOG4107RT3 EamA-like transporter family DTO10_22740 ENOG4108VUG Enoyl-CoA hydratase DTO10_22745 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DTO10_22750 ENOG4107XWI flavin reductase domain protein, FMN-binding DTO10_22765 ENOG4105DRR Transcriptional regulator, GntR family DTO10_22770 ENOG4105E39 Enoyl-CoA hydratase DTO10_22775 ENOG4105DKW ABC transporter DTO10_22805 ENOG4105CS9 pantothenic acid kinase DTO10_22815 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) DTO10_22820 ENOG4105CI1 PTS System DTO10_22830 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DTO10_22855 ENOG4105DJB Major Facilitator Superfamily DTO10_22860 ENOG4105BZ4 penicillin-binding protein DTO10_22870 ENOG4105VRS hydrolase family 18 DTO10_22890 ENOG4105CUB amino acid DTO10_22895 ENOG4105D82 Glutamate dehydrogenase DTO10_22910 ENOG41069ER domain protein DTO10_22935 ENOG4105XTG Pfam:DUF156 DTO10_22945 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DTO10_22955 ENOG4105VFE sira family DTO10_22960 ENOG4105VFE sira family DTO10_22970 ENOG4107TPS domain protein DTO10_22975 ENOG4105VFE sira family DTO10_22980 ENOG41087NI Sulfite exporter TauE/SafE DTO10_23000 ENOG4108JUB Transcriptional regulator DTO10_23005 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) DTO10_23010 ENOG4105E39 Enoyl-CoA hydratase DTO10_23020 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DTO10_23025 ENOG4108Z0R Transferase DTO10_23035 ENOG4105SKE transcriptional Regulator LysR family DTO10_23045 ENOG4105C8J )-transporter DTO10_23055 ENOG4105CMU LysR family (Transcriptional regulator DTO10_23060 ENOG4105CY2 Citrate transporter DTO10_23070 ENOG4107WD8 ABC transporter, permease DTO10_23090 ENOG4105BZU Histidine kinase DTO10_23095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DTO10_23135 ENOG4107Z6I Thiamine biosynthesis protein DTO10_23150 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DTO10_23170 ENOG4108NA0 Uncharacterized conserved protein (COG2071) DTO10_23175 ENOG4105CBC glutamate synthase DTO10_23185 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DTO10_23195 ENOG4108PJD permease DTO10_23205 ENOG4105VPX protein, conserved in bacteria DTO10_23210 ENOG410681U heavy metal transport detoxification protein DTO10_23215 ENOG4105C59 p-type ATPase DTO10_23225 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein DTO10_23230 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DTO10_23235 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DTO10_23240 ENOG4105C3U ABC transporter DTO10_23245 ENOG4108JQ7 (ABC) transporter DTO10_23260 ENOG4105DGI Alkaline phosphatase DTO10_23265 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DTO10_23270 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DTO10_23275 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DTO10_23295 ENOG4105CYP glycoside hydrolase, family DTO10_23340 ENOG4105N82 Endonuclease DTO10_23370 ENOG41061CK Antibiotic biosynthesis monooxygenase DTO10_23415 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DTO10_23455 ENOG4105E66 phosphoriboisomerase A DTO10_23480 ENOG4105VTR Integrase DTO10_23500 ENOG4105WD1 Membrane DTO10_23510 ENOG4108JUA Transcriptional regulator DTO10_23515 ENOG4108JUB Transcriptional regulator DTO10_23530 ENOG4105C85 amino acid DTO10_23540 ENOG4108KAZ Involved in phosphonate degradation (By similarity) DTO10_23550 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DTO10_23555 ENOG4108TN2 lmbE family DTO10_23570 ENOG4105DEN Luciferase family DTO10_23580 ENOG41082BV acetyltransferase DTO10_23585 ENOG4108U05 Transcriptional regulator DTO10_23590 ENOG4105BZ1 (ABC) transporter DTO10_23600 ENOG4105K56 Transcriptional regulator DTO10_23610 ENOG4108Q8B Spore germination protein DTO10_23625 ENOG4105CPP Dehydrogenase, E1 component DTO10_23630 ENOG4105C7S Dehydrogenase DTO10_23635 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DTO10_23660 ENOG4105SX7 Transporter DTO10_23685 ENOG4105IQ5 FAD linked oxidase domain protein DTO10_23690 ENOG4108IG5 Transcriptional regulator DTO10_23705 ENOG4105CGP Urocanate hydratase DTO10_23710 ENOG4105CI2 imidazolone-5-propionate hydrolase DTO10_23720 ENOG4108I5G Major Facilitator superfamily DTO10_23730 ENOG4105C54 Major Facilitator superfamily DTO10_23735 ENOG4105C84 Histidine ammonia-lyase DTO10_23745 ENOG4105E7W lamb ycsf family protein DTO10_23750 ENOG4105C5A transporter DTO10_23755 ENOG4105CFM UPF0317 protein DTO10_23760 ENOG4105P4J Allophanate hydrolase, subunit 1 DTO10_23775 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) DTO10_23815 ENOG4105WH1 Two component transcriptional regulator luxr family DTO10_23825 ENOG4105BZU Histidine kinase DTO10_23830 ENOG4107258 Transcriptional regulator DTO10_23845 ENOG4105HEI LysR family (Transcriptional regulator DTO10_23865 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DTO10_23870 ENOG4105FDT acyl-CoA dehydrogenase DTO10_23890 ENOG4105CDA abc transporter atp-binding protein DTO10_23895 ENOG4108RAV Conserved protein DTO10_23915 ENOG4107TS3 membrane protein, TerC DTO10_23930 ENOG4108JJB ABC transporter DTO10_23935 ENOG4108V4M Cobalt abc transporter DTO10_23945 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) DTO10_23955 ENOG4105E4R Precorrin-3B C17-methyltransferase DTO10_23960 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DTO10_23965 ENOG4108JTQ reductase DTO10_23970 ENOG41081F0 Precorrin-8x methylmutase DTO10_23975 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) DTO10_23980 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase DTO10_23985 ENOG4105DVK Precorrin-2 c20-methyltransferase DTO10_23990 ENOG4105CIA precorrin-4 C(11)-methyltransferase DTO10_23995 ENOG4108P62 biosynthesis protein (CbiG) DTO10_24000 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DTO10_24005 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DTO10_24010 ENOG41069NU Nitroreductase DTO10_24015 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase DTO10_24020 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DTO10_24025 ENOG4105K70 DNA-binding protein DTO10_24035 ENOG4105G0J serine threonine protein kinase DTO10_24040 ENOG4108XI2 Domain of unknown function (DUF1963) DTO10_24060 ENOG4105C1G acyl-Coa dehydrogenase DTO10_24070 ENOG4108IPT Naphthoate synthase DTO10_24075 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_24085 ENOG4105C1G acyl-Coa dehydrogenase DTO10_24090 ENOG4105ETU transcriptional activator (TenA DTO10_24095 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein DTO10_24100 ENOG4108JJB ABC transporter DTO10_24110 ENOG4108VEU Thiamine monophosphate synthase DTO10_24115 ENOG41080HI glycine oxidase DTO10_24120 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) DTO10_24125 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) DTO10_24130 ENOG4105D06 uba thif-type nad fad binding protein DTO10_24135 ENOG41076DU acid-soluble spore protein P DTO10_24145 ENOG410746C Acid-soluble spore protein O DTO10_24150 ENOG4108I0Z Aconitate hydratase DTO10_24155 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DTO10_24170 ENOG41067CD Small, acid-soluble spore protein Tlp DTO10_24180 ENOG4105MI2 DTO10_24185 ENOG4105W8X HesB YadR YfhF-family protein DTO10_24190 ENOG4105E09 nadh pyrophosphatase DTO10_24205 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DTO10_24210 ENOG4105K4P CoA-binding domain protein DTO10_24215 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DTO10_24225 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_24230 ENOG4105C1G acyl-Coa dehydrogenase DTO10_24235 ENOG4105C1G acyl-Coa dehydrogenase DTO10_24240 ENOG4105CHR reductase DTO10_24260 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_24275 ENOG4105C32 Amino acid ABC transporter (Permease) DTO10_24280 ENOG4105CF8 branched-chain amino acid ABC transporter, permease DTO10_24285 ENOG4105C0Z ABC transporter DTO10_24290 ENOG4108IV0 ABC, transporter DTO10_24305 ENOG4106GRI small acid-soluble spore protein H DTO10_24310 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DTO10_24330 ENOG4105D17 glycoside hydrolase, family 3 domain protein DTO10_24335 ENOG4105EHZ conserved protein UCP016719 DTO10_24350 ENOG4105D9R oxidoreductase DTO10_24370 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_24375 ENOG41069H0 dihydroorotase EC 3.5.2.3 DTO10_24395 ENOG4105FDP GntR family transcriptional regulator DTO10_24400 ENOG4105C6Z Gluconate DTO10_24420 ENOG4107HP6 Transcriptional regulator DTO10_24435 ENOG4105CHR reductase DTO10_24440 ENOG4105C7K acetolactate synthase DTO10_24445 ENOG4105C26 Dehydrogenase DTO10_24455 ENOG4105FUY alpha subunit DTO10_24465 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase DTO10_24490 ENOG4105DTD Dehydrogenase DTO10_24495 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) DTO10_24500 ENOG4105CHU acetyl-coa acetyltransferase DTO10_24505 ENOG4108JUB Transcriptional regulator DTO10_24510 ENOG4105CY2 Citrate transporter DTO10_24515 ENOG4105D6N CoA-transferase, subunit a DTO10_24520 ENOG4108IIH CoA-transferase subunit B DTO10_24530 ENOG4108B31 Spore germination protein DTO10_24545 ENOG4108S4H thioesterase Superfamily protein DTO10_24570 ENOG4105C1G acyl-Coa dehydrogenase DTO10_24575 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_24580 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DTO10_24585 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DTO10_24590 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DTO10_24595 ENOG4105E39 Enoyl-CoA hydratase DTO10_24600 ENOG4107QX3 carboxylase DTO10_24615 ENOG4105DAP Nicotinate phosphoribosyltransferase DTO10_24620 ENOG4107RA1 nh(3)-dependent nad( ) synthetase DTO10_24705 ENOG4105HHM rdd domain containing protein DTO10_24735 ENOG4105CHJ isochorismatase hydrolase DTO10_24745 ENOG4108R1P DTO10_24750 ENOG4105CUB amino acid DTO10_24755 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DTO10_24765 ENOG4105D2S major facilitator superfamily DTO10_24775 ENOG4105D2S major facilitator superfamily DTO10_24780 ENOG4105KK4 UPF0060 membrane protein DTO10_24785 ENOG4105SX7 Transporter DTO10_24810 ENOG4108MXF Alpha Beta Hydrolase DTO10_24815 ENOG4107TTQ Alpha beta hydrolase fold DTO10_24830 ENOG4108JUB Transcriptional regulator DTO10_24835 ENOG4105CHR reductase DTO10_24840 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_24845 ENOG4108I5G Major Facilitator superfamily DTO10_24860 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class DTO10_24865 ENOG4107PP3 Acetylornithine deacetylase DTO10_24900 ENOG4105BZU Histidine kinase DTO10_24925 ENOG4105DUM transcriptional regulator, lysR family DTO10_24930 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_24955 ENOG4105CHR reductase DTO10_24965 ENOG4105DJB Major Facilitator Superfamily DTO10_24975 ENOG4108IIH CoA-transferase subunit B DTO10_24980 ENOG4107RSM transcriptional regulator DTO10_24985 ENOG4108R85 Short chain dehydrogenase DTO10_24995 ENOG4108W6C Dehydrogenase DTO10_25000 ENOG4105C1G acyl-Coa dehydrogenase DTO10_25010 ENOG4105CHU acetyl-coa acetyltransferase DTO10_25050 ENOG4108IUM Glycogen debranching enzyme DTO10_25085 ENOG4108PVQ transcriptional regulator DTO10_25090 ENOG4105D5U fad dependent oxidoreductase DTO10_25105 ENOG4105EK3 May be involved in the control of utilization of gamma- aminobutyric acid (By similarity) DTO10_25110 ENOG4107VFR oxidoreductase DTO10_25125 ENOG4105CBC glutamate synthase DTO10_25130 ENOG4107VHA regulatoR DTO10_25135 ENOG4105BZW Glycerate kinase DTO10_25140 ENOG4105C6Z Gluconate DTO10_25175 ENOG4108XRC Protein of unknown function (DUF458) DTO10_25190 ENOG4105BZU Histidine kinase DTO10_25195 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DTO10_25210 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DTO10_25215 ENOG4105F38 ABC transporter, permease DTO10_25220 ENOG4105D38 putrescine abc transporter DTO10_25255 ENOG4105CPT Alpha beta hydrolase DTO10_25260 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DTO10_25285 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DTO10_25290 ENOG4105CHR reductase DTO10_25300 ENOG4107QKR Dehydrogenase DTO10_25310 ENOG4107RUY (E1 component), alpha subunit DTO10_25315 ENOG4108RZE Tetr family transcriptional regulator DTO10_25330 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DTO10_25335 ENOG4105BZU Histidine kinase DTO10_25340 ENOG4105FDT acyl-CoA dehydrogenase DTO10_25345 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DTO10_25355 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DTO10_25375 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) DTO10_25430 ENOG4108MCI Transcriptional regulator, ARAC family DTO10_25435 ENOG4108UZ3 Transporter DTO10_25440 ENOG4105C5I Dehydrogenase DTO10_25445 ENOG4105CHR reductase DTO10_25450 ENOG4105CMG Carbohydrate kinase DTO10_25455 ENOG4105DT3 PTS system, galactitol-specific IIc component DTO10_25465 ENOG41061GT Aldolase DTO10_25480 ENOG4105C7K acetolactate synthase DTO10_25485 ENOG4105CHM Aminotransferase DTO10_25500 ENOG4107258 Transcriptional regulator DTO10_25530 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DTO10_25535 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DTO10_25550 ENOG4105D8X mechanosensitive ion channel DTO10_25570 ENOG4105IIU Aminopeptidase DTO10_25610 ENOG4105DUM transcriptional regulator, lysR family DTO10_25635 ENOG4105IIU Aminopeptidase DTO10_25655 ENOG4105DJB Major Facilitator Superfamily DTO10_25660 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_25675 ENOG4105BZU Histidine kinase DTO10_25680 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DTO10_25685 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DTO10_25690 ENOG4105DUM transcriptional regulator, lysR family DTO10_25715 ENOG4105C7K acetolactate synthase DTO10_25740 ENOG4105CI0 Citrate lyase DTO10_25750 ENOG4105D4T Citrate transporter DTO10_25755 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DTO10_25760 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DTO10_25765 ENOG4108WYP Transcriptional regulator DTO10_25780 ENOG4105DTQ mandelate racemase muconate lactonizing DTO10_25790 ENOG4107S4Y M20 DapE family protein YgeY DTO10_25805 ENOG4108JQ7 (ABC) transporter DTO10_25845 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DTO10_25850 ENOG4108JUB Transcriptional regulator DTO10_25860 ENOG4107UWY Methyltransferase DTO10_25870 ENOG4107CUJ Protein of unknown function (DUF2690) DTO10_25875 ENOG4107CUJ Protein of unknown function (DUF2690) DTO10_25890 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DTO10_25895 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DTO10_25905 ENOG4105GPN Uncharacterized conserved protein (DUF2294) DTO10_25915 ENOG4105F0V Cell wall hydrolase DTO10_25925 ENOG4105E1V na solute symporter DTO10_25930 ENOG4106CAD Protein of unknown function (DUF3311) DTO10_25935 ENOG4105CE7 Amidase, hydantoinase carbamoylase family DTO10_25955 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DTO10_25970 ENOG4105DGI Alkaline phosphatase DTO10_25975 ENOG4105DGI Alkaline phosphatase DTO10_25980 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DTO10_26000 ENOG4106CAD Protein of unknown function (DUF3311) DTO10_26010 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DTO10_26030 ENOG4105C26 Dehydrogenase DTO10_26035 ENOG4105MWK D-amino acid dehydrogenase, small subunit DTO10_26060 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DTO10_26070 ENOG4105EKQ RNA-directed DNA polymerase DTO10_26135 ENOG4105DPN Oligoendopeptidase f DTO10_26150 ENOG4105CIY formyltetrahydrofolate deformylase DTO10_26165 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DTO10_26170 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DTO10_26175 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DTO10_26180 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DTO10_26190 ENOG4105EJQ L-serine dehydratase DTO10_26205 ENOG4105C85 amino acid DTO10_26210 ENOG4105KPY Small multidrug resistance protein DTO10_26215 ENOG4105KPY Small multidrug resistance protein DTO10_26220 ENOG410667J hydrolase DTO10_26225 ENOG4105E98 transcriptional regulator DeoR family DTO10_26230 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DTO10_26260 ENOG4105CYW agmatinase DTO10_26265 ENOG4105C26 Dehydrogenase DTO10_26275 ENOG4105C26 Dehydrogenase DTO10_26280 ENOG4105CUB amino acid DTO10_26325 ENOG4108B31 Spore germination protein DTO10_26410 ENOG4107STQ Multicopper oxidase DTO10_26450 ENOG4105VUF Transcriptional regulator DTO10_26490 ENOG4107Y2X deaminase DTO10_26520 ENOG41061CK Antibiotic biosynthesis monooxygenase DTO10_26525 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DTO10_26535 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 DTO10_26540 ENOG4108U05 Transcriptional regulator DTO10_26560 ENOG4105PNM synthesis protein DTO10_26600 ENOG4105QIV RNA polymerase DTO10_26615 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase DTO10_26620 ENOG4105C26 Dehydrogenase DTO10_26625 ENOG4105E3J oxidoreductase DTO10_26655 ENOG4105VRS hydrolase family 18 DTO10_26680 ENOG4105CEY Amp-dependent synthetase and ligase DTO10_26685 ENOG4105DU0 nucleoside hydrolase DTO10_26690 ENOG4105D9N nucleoside DTO10_26695 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) DTO10_26700 ENOG4105DD7 kinase (PfkB family DTO10_26710 ENOG4108RVA ribokinase DTO10_26720 ENOG4105C26 Dehydrogenase DTO10_26725 ENOG4105C1G acyl-Coa dehydrogenase DTO10_26730 ENOG4105CC9 acyl-Coa dehydrogenase DTO10_26750 ENOG410900P UPF0336 protein DTO10_26755 ENOG4105CD5 CoA-binding domain protein