locus-tag	class	description
CWI35_00010	COG0789	Transcriptional regulator
CWI35_00015	COG1664	Polymer-forming cytoskeletal
CWI35_00035	COG3858	chitin binding
CWI35_00035	COG1388	LysM domain
CWI35_00040	COG2210	Belongs to the sulfur carrier protein TusA family
CWI35_00050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWI35_00050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWI35_00055	COG2226	methyltransferase
CWI35_00065	COG1937	Protein conserved in bacteria
CWI35_00070	COG0425	Belongs to the sulfur carrier protein TusA family
CWI35_00075	COG2210	Belongs to the sulfur carrier protein TusA family
CWI35_00085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWI35_00090	COG0425	Belongs to the sulfur carrier protein TusA family
CWI35_00090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWI35_00095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWI35_00095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWI35_00100	COG0730	response to heat
CWI35_00125	COG0561	phosphatase activity
CWI35_00135	COG0710	3-dehydroquinate dehydratase activity
CWI35_00140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CWI35_00155	COG0463	Glycosyl transferase, family 2
CWI35_00160	COG2246	polysaccharide biosynthetic process
CWI35_00170	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CWI35_00175	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CWI35_00190	COG0129	dihydroxy-acid dehydratase activity
CWI35_00195	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CWI35_00200	COG3396	Phenylacetate-CoA oxygenase
CWI35_00215	COG2151	metal-sulfur cluster biosynthetic enzyme
CWI35_00225	COG1024	Enoyl-CoA hydratase
CWI35_00230	COG1024	Enoyl-CoA hydratase
CWI35_00235	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_00240	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWI35_00245	COG0183	Belongs to the thiolase family
CWI35_00250	COG3327	negative regulation of DNA-templated transcription, initiation
CWI35_00275	COG4120	Belongs to the binding-protein-dependent transport system permease family
CWI35_00280	COG3842	ATPase activity
CWI35_00290	COG0022	dehydrogenase e1 component
CWI35_00310	COG3104	oligopeptide transport
CWI35_00315	COG3842	ATPase activity
CWI35_00320	COG1175	transmembrane transport
CWI35_00335	COG2186	Transcriptional regulator
CWI35_00340	COG0277	FAD linked oxidase domain protein
CWI35_00345	COG0247	lactate metabolic process
CWI35_00350	COG1840	ABC-type Fe3 transport system, periplasmic component
CWI35_00360	COG1176	ABC-type spermidine putrescine transport system, permease component I
CWI35_00370	COG0579	oxidoreductase
CWI35_00380	COG2843	Capsule synthesis protein
CWI35_00425	COG2151	metal-sulfur cluster biosynthetic enzyme
CWI35_00440	COG1024	Enoyl-CoA hydratase
CWI35_00460	COG0385	Bile acid
CWI35_00480	COG2154	pterin-4-alpha-carbinolamine dehydratase
CWI35_00495	COG0784	Response regulator, receiver
CWI35_00500	COG4191	Histidine kinase
CWI35_00505	COG0765	amino acid transport
CWI35_00510	COG0765	amino acid transport
CWI35_00525	COG0667	Aldo Keto reductase
CWI35_00545	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_00570	COG3711	transcriptional antiterminator
CWI35_00580	COG0246	Mannitol dehydrogenase
CWI35_00610	COG3290	protein histidine kinase activity
CWI35_00615	COG4565	transcriptional regulatory protein
CWI35_00620	COG0679	Auxin Efflux Carrier
CWI35_00625	COG1609	Transcriptional regulator
CWI35_00640	COG0840	transmembrane signaling receptor activity
CWI35_00650	COG0559	Belongs to the binding-protein-dependent transport system permease family
CWI35_00660	COG0411	ABC transporter
CWI35_00665	COG0410	ABC transporter
CWI35_00670	COG0831	urea catabolic process
CWI35_00675	COG0832	Belongs to the urease beta subunit family
CWI35_00680	COG0804	urea catabolic process
CWI35_00685	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CWI35_00690	COG0830	nickel cation binding
CWI35_00710	COG0456	acetyltransferase
CWI35_00735	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CWI35_00740	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_00745	COG1024	Enoyl-CoA hydratase
CWI35_00750	COG2376	Dihydroxyacetone kinase
CWI35_00800	COG1070	Carbohydrate kinase
CWI35_00815	COG3290	protein histidine kinase activity
CWI35_00815	COG3829	transcription factor binding
CWI35_00825	COG1454	alcohol dehydrogenase
CWI35_00835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWI35_00840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CWI35_00845	COG2146	nitrite reductase [NAD(P)H] activity
CWI35_00850	COG0243	molybdopterin cofactor binding
CWI35_00855	COG2223	nitrite transmembrane transporter activity
CWI35_00860	COG1846	Transcriptional regulator
CWI35_00870	COG0789	Transcriptional regulator
CWI35_00875	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWI35_00880	COG1447	Phosphotransferase system cellobiose-specific component IIA
CWI35_00885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWI35_00890	COG2723	6-phospho-beta-galactosidase activity
CWI35_00895	COG2188	Transcriptional regulator
CWI35_00905	COG0726	polysaccharide deacetylase
CWI35_00910	COG1408	metallophosphoesterase
CWI35_00915	COG1757	Na H antiporter
CWI35_00925	COG0385	Bile acid
CWI35_00965	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CWI35_00965	COG2199	diguanylate cyclase activity
CWI35_00975	COG1349	DNA-binding transcription factor activity
CWI35_00980	COG1105	Belongs to the carbohydrate kinase PfkB family
CWI35_00985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWI35_00985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWI35_00985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWI35_00990	COG0701	Predicted permease
CWI35_00995	COG3689	TIGRFAM TIGR03943 family protein
CWI35_01005	COG0432	Pfam Uncharacterised protein family UPF0047
CWI35_01010	COG0024	Methionine aminopeptidase
CWI35_01015	COG5002	protein histidine kinase activity
CWI35_01020	COG4412	M6 family metalloprotease domain protein
CWI35_01020	COG3291	Pkd domain containing protein
CWI35_01030	COG1587	Uroporphyrinogen-III synthase
CWI35_01040	COG2181	nitrate reductase activity
CWI35_01045	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CWI35_01050	COG1140	nitrate reductase beta subunit
CWI35_01055	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CWI35_01080	COG0706	membrane insertase activity
CWI35_01090	COG1335	isochorismatase
CWI35_01095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CWI35_01100	COG1164	Oligoendopeptidase f
CWI35_01105	COG4989	oxidoreductase activity
CWI35_01120	COG0584	glycerophosphoryl diester phosphodiesterase
CWI35_01180	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CWI35_01210	COG1492	cobalamin metabolic process
CWI35_01215	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CWI35_01245	COG0386	Belongs to the glutathione peroxidase family
CWI35_01250	COG1413	lyase activity
CWI35_01275	COG0494	nUDIX hydrolase
CWI35_01290	COG0436	Aminotransferase
CWI35_01305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CWI35_01310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CWI35_01320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWI35_01335	COG1999	signal sequence binding
CWI35_01340	COG2755	lipolytic protein G-D-S-L family
CWI35_01350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWI35_01350	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CWI35_01355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CWI35_01385	COG0737	Belongs to the 5'-nucleotidase family
CWI35_01385	COG1525	nuclease
CWI35_01385	COG4085	toxin activity
CWI35_01390	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWI35_01400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CWI35_01405	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CWI35_01430	COG3647	Membrane
CWI35_01475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWI35_01485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CWI35_01495	COG1832	CoA-binding protein
CWI35_01500	COG0187	DNA topoisomerase II activity
CWI35_01505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWI35_01520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWI35_01520	COG1263	PTS System
CWI35_01525	COG0366	Alpha amylase catalytic
CWI35_01530	COG2188	Transcriptional regulator
CWI35_01535	COG1757	Na H antiporter
CWI35_01545	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CWI35_01545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CWI35_01550	COG1960	acyl-CoA dehydrogenase activity
CWI35_01555	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CWI35_01560	COG1959	2 iron, 2 sulfur cluster binding
CWI35_01565	COG1017	nitric oxide dioxygenase activity
CWI35_01565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CWI35_01570	COG0788	formyltetrahydrofolate deformylase activity
CWI35_01580	COG0714	Associated with various cellular activities
CWI35_01585	COG4548	von Willebrand factor, type A
CWI35_01590	COG2404	hydrolase activity, acting on ester bonds
CWI35_01630	COG1279	arginine transmembrane transporter activity
CWI35_01640	COG3402	PFAM membrane-flanked domain
CWI35_01645	COG1113	amino acid transport
CWI35_01655	COG1388	LysM domain
CWI35_01665	COG0745	RESPONSE REGULATOR receiver
CWI35_01670	COG5002	protein histidine kinase activity
CWI35_01675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWI35_01675	COG0551	DNA topoisomerase type I activity
CWI35_01685	COG0515	serine threonine protein kinase
CWI35_01690	COG1024	Enoyl-CoA hydratase
CWI35_01700	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_01725	COG1119	ATPase activity
CWI35_01730	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CWI35_01765	COG0697	spore germination
CWI35_01780	COG0410	ABC transporter
CWI35_01785	COG0411	ABC transporter
CWI35_01795	COG0559	Belongs to the binding-protein-dependent transport system permease family
CWI35_01805	COG0183	Belongs to the thiolase family
CWI35_01815	COG2030	dehydratase
CWI35_01825	COG1960	acyl-CoA dehydrogenase activity
CWI35_01830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CWI35_01835	COG0778	Nitroreductase
CWI35_01840	COG1741	Belongs to the pirin family
CWI35_01850	COG2337	Toxic component of a toxin-antitoxin (TA) module
CWI35_01895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CWI35_01900	COG1131	(ABC) transporter
CWI35_01920	COG0730	response to heat
CWI35_01945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWI35_01950	COG2258	MOSC domain
CWI35_01955	COG1132	(ABC) transporter
CWI35_01960	COG1132	(ABC) transporter
CWI35_01985	COG2208	phosphoserine phosphatase activity
CWI35_01990	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CWI35_02000	COG0697	spore germination
CWI35_02015	COG1131	(ABC) transporter
CWI35_02020	COG1725	Transcriptional regulator
CWI35_02045	COG2223	nitrite transmembrane transporter activity
CWI35_02050	COG2205	protein histidine kinase activity
CWI35_02100	COG2814	Major facilitator Superfamily
CWI35_02105	COG1566	PFAM secretion protein HlyD family protein
CWI35_02110	COG1846	Transcriptional regulator
CWI35_02120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CWI35_02125	COG1024	Enoyl-CoA hydratase
CWI35_02130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWI35_02135	COG0511	ligase activity, forming carbon-carbon bonds
CWI35_02140	COG0439	Biotin carboxylase
CWI35_02145	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_02150	COG1960	acyl-CoA dehydrogenase activity
CWI35_02155	COG1309	transcriptional regulator
CWI35_02180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWI35_02190	COG3852	Histidine kinase
CWI35_02195	COG0534	Mate efflux family protein
CWI35_02215	COG2962	Rard protein
CWI35_02225	COG0598	Magnesium transport protein CorA
CWI35_02230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CWI35_02235	COG2226	methyltransferase
CWI35_02240	COG1876	peptidase activity
CWI35_02245	COG0813	purine-nucleoside phosphorylase activity
CWI35_02285	COG4479	Belongs to the UPF0346 family
CWI35_02290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CWI35_02310	COG4841	protein insertion into membrane
CWI35_02315	COG2050	protein possibly involved in aromatic compounds catabolism
CWI35_02325	COG0824	Thioesterase
CWI35_02345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWI35_02365	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CWI35_02370	COG1755	Isoprenylcysteine carboxyl methyltransferase
CWI35_02375	COG3424	synthase
CWI35_02385	COG2233	PERMEase
CWI35_02390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWI35_02400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CWI35_02405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CWI35_02410	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CWI35_02415	COG1199	ATP-dependent helicase activity
CWI35_02420	COG0116	Belongs to the methyltransferase superfamily
CWI35_02430	COG3599	regulation of cell shape
CWI35_02450	COG3359	exonuclease
CWI35_02455	COG1205	dead DEAH box helicase
CWI35_02455	COG1111	helicase
CWI35_02460	COG1414	Transcriptional regulator
CWI35_02465	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWI35_02470	COG0281	malic enzyme
CWI35_02475	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CWI35_02480	COG0277	FAD linked oxidase domain protein
CWI35_02485	COG0247	lactate metabolic process
CWI35_02490	COG0277	FAD linked oxidase domain protein
CWI35_02500	COG3622	Belongs to the hyi family
CWI35_02505	COG0670	Belongs to the BI1 family
CWI35_02525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CWI35_02535	COG5002	protein histidine kinase activity
CWI35_02555	COG5577	PFAM Coat F domain
CWI35_02565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWI35_02570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWI35_02595	COG3594	Acyltransferase
CWI35_02600	COG0352	thiamine-phosphate diphosphorylase activity
CWI35_02605	COG0351	phosphomethylpyrimidine kinase
CWI35_02610	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CWI35_02615	COG0463	Glycosyl transferase, family 2
CWI35_02635	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_02650	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CWI35_02655	COG1984	allophanate hydrolase subunit 2
CWI35_02660	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CWI35_02665	COG1414	Transcriptional regulator
CWI35_02675	COG0456	acetyltransferase
CWI35_02680	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CWI35_02680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CWI35_02700	COG2135	peptidase activity
CWI35_02710	COG1960	acyl-CoA dehydrogenase activity
CWI35_02715	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_02740	COG4555	ABC transporter
CWI35_02750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWI35_02760	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CWI35_02765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CWI35_02770	COG3279	Response regulator of the LytR AlgR family
CWI35_02790	COG1366	Belongs to the anti-sigma-factor antagonist family
CWI35_02800	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_02805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWI35_02830	COG2200	EAL domain
CWI35_02845	COG0406	alpha-ribazole phosphatase activity
CWI35_02875	COG1120	ATPase activity
CWI35_02880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWI35_02885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWI35_02920	COG0004	ammonium transporteR
CWI35_02940	COG3853	Toxic anion resistance protein (TelA)
CWI35_03000	COG2340	Cysteine-rich secretory protein family
CWI35_03010	COG4821	SIS domain
CWI35_03030	COG0697	spore germination
CWI35_03040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CWI35_03060	COG0671	phosphoesterase, PA-phosphatase related
CWI35_03065	COG0493	'glutamate synthase
CWI35_03070	COG0069	glutamate synthase activity
CWI35_03070	COG0067	glutamate synthase
CWI35_03070	COG0070	glutamate synthase
CWI35_03075	COG0583	DNA-binding transcription factor activity
CWI35_03080	COG0604	alcohol dehydrogenase
CWI35_03090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CWI35_03095	COG2508	Transcriptional regulator
CWI35_03100	COG1113	amino acid transport
CWI35_03140	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CWI35_03145	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CWI35_03150	COG0583	DNA-binding transcription factor activity
CWI35_03160	COG0640	Transcriptional regulator
CWI35_03165	COG0393	Putative heavy-metal-binding
CWI35_03190	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CWI35_03195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWI35_03200	COG5582	Belongs to the UPF0302 family
CWI35_03205	COG0579	oxidoreductase
CWI35_03260	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CWI35_03265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWI35_03305	COG3384	dioxygenase
CWI35_03310	COG0653	protein targeting
CWI35_03320	COG2313	pseudouridylate synthase activity
CWI35_03335	COG2391	methyltransferase activity
CWI35_03340	COG1970	mechanosensitive ion channel activity
CWI35_03350	COG1228	amidohydrolase
CWI35_03355	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CWI35_03360	COG1917	Cupin 2, conserved barrel domain protein
CWI35_03360	COG4977	sequence-specific DNA binding
CWI35_03365	COG0010	Belongs to the arginase family
CWI35_03380	COG0346	lactoylglutathione lyase activity
CWI35_03400	COG0601	transmembrane transport
CWI35_03405	COG4608	Belongs to the ABC transporter superfamily
CWI35_03425	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CWI35_03465	COG0328	RNA-DNA hybrid ribonuclease activity
CWI35_03480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CWI35_03505	COG1388	LysM domain
CWI35_03505	COG1705	Flagellar rod assembly protein muramidase FlgJ
CWI35_03515	COG4846	Membrane protein involved in cytochrome C biogenesis
CWI35_03520	COG2201	protein-glutamate methylesterase activity
CWI35_03525	COG0785	Cytochrome C biogenesis protein
CWI35_03535	COG1132	(ABC) transporter
CWI35_03540	COG1132	(ABC) transporter
CWI35_03545	COG3763	UPF0154 protein
CWI35_03560	COG4224	UPF0291 protein
CWI35_03570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CWI35_03575	COG1388	LysM domain
CWI35_03580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CWI35_03585	COG0174	glutamine synthetase
CWI35_03590	COG0789	Transcriptional regulator
CWI35_03595	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CWI35_03600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CWI35_03605	COG2860	membrane
CWI35_03610	COG0697	spore germination
CWI35_03620	COG0183	Belongs to the thiolase family
CWI35_03625	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWI35_03630	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_03635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWI35_03640	COG1960	acyl-CoA dehydrogenase activity
CWI35_03650	COG0464	growth
CWI35_03655	COG1923	regulation of RNA biosynthetic process
CWI35_03660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CWI35_03665	COG0840	transmembrane signaling receptor activity
CWI35_03670	COG0477	Major facilitator Superfamily
CWI35_03685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CWI35_03690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CWI35_03705	COG4550	Control of competence regulator ComK, YlbF/YmcA
CWI35_03710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWI35_03715	COG1013	pyruvate-flavodoxin oxidoreductase activity
CWI35_03720	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CWI35_03720	COG0674	pyruvate-flavodoxin oxidoreductase activity
CWI35_03730	COG2359	stage V sporulation protein S
CWI35_03735	COG1692	metallophosphoesterase
CWI35_03740	COG1418	mRNA catabolic process
CWI35_03765	COG1058	Belongs to the CinA family
CWI35_03765	COG1546	Belongs to the CinA family
CWI35_03770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CWI35_03775	COG1426	Protein conserved in bacteria
CWI35_03790	COG0300	oxidoreductase activity
CWI35_03795	COG0612	Peptidase, M16
CWI35_03800	COG0612	Peptidase, M16
CWI35_03830	COG2188	Transcriptional regulator
CWI35_03835	COG1674	ftsk spoiiie
CWI35_03835	COG4980	gas vesicle protein
CWI35_03850	COG0740	serine-type endopeptidase activity
CWI35_03855	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CWI35_03860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWI35_03865	COG0527	aspartate kinase activity
CWI35_03870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CWI35_03875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CWI35_03880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CWI35_03885	COG1873	PFAM PRC-barrel domain
CWI35_03890	COG0612	Peptidase, M16
CWI35_03895	COG0726	polysaccharide deacetylase
CWI35_03900	COG1185	polyribonucleotide nucleotidyltransferase activity
CWI35_03905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CWI35_03910	COG0196	riboflavin kinase activity
CWI35_03915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CWI35_03920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CWI35_03925	COG1550	Protein conserved in bacteria
CWI35_03935	COG1358	cellular component organization or biogenesis
CWI35_03940	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CWI35_03945	COG0195	Participates in both transcription termination and antitermination
CWI35_03950	COG0779	Required for maturation of 30S ribosomal subunits
CWI35_03955	COG2176	DNA-directed DNA polymerase activity
CWI35_03960	COG0442	prolyl-tRNA aminoacylation
CWI35_03965	COG0750	zinc metalloprotease
CWI35_03970	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CWI35_03975	COG4589	Belongs to the CDS family
CWI35_03980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CWI35_03985	COG0233	cytoplasmic translational termination
CWI35_03990	COG0528	UMP kinase activity
CWI35_03995	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CWI35_04000	COG0052	Belongs to the universal ribosomal protein uS2 family
CWI35_04015	COG1191	sigma factor activity
CWI35_04020	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CWI35_04025	COG1776	CheC inhibitor of MCP methylation
CWI35_04030	COG0835	chemotaxis
CWI35_04035	COG0643	Histidine kinase
CWI35_04035	COG2198	Histidine kinase
CWI35_04040	COG2201	protein-glutamate methylesterase activity
CWI35_04045	COG0455	bacterial-type flagellum organization
CWI35_04050	COG1419	protein localization to endoplasmic reticulum
CWI35_04055	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CWI35_04060	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CWI35_04085	COG1987	bacterial-type flagellum assembly
CWI35_04090	COG1338	Plays a role in the flagellum-specific transport system
CWI35_04095	COG3190	flagellar
CWI35_04100	COG2201	protein-glutamate methylesterase activity
CWI35_04105	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CWI35_04105	COG1776	CheC inhibitor of MCP methylation
CWI35_04110	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CWI35_04120	COG1582	Flagellar protein (FlbD)
CWI35_04125	COG4786	Flagellar basal body rod
CWI35_04130	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CWI35_04135	COG3144	bacterial-type flagellum assembly
CWI35_04145	COG2882	bacterial-type flagellum organization
CWI35_04150	COG1157	protein secretion by the type III secretion system
CWI35_04155	COG1317	bacterial-type flagellum organization
CWI35_04160	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CWI35_04165	COG1766	The M ring may be actively involved in energy transduction
CWI35_04170	COG1677	Flagellar hook-basal body complex protein FliE
CWI35_04180	COG1815	bacterial-type flagellum-dependent cell motility
CWI35_04185	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CWI35_04190	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CWI35_04195	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CWI35_04200	COG4974	Belongs to the 'phage' integrase family
CWI35_04205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWI35_04210	COG0758	DNA mediated transformation
CWI35_04215	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CWI35_04220	COG0045	succinate-CoA ligase (ADP-forming) activity
CWI35_04225	COG2257	FlhB HrpN YscU SpaS Family
CWI35_04235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CWI35_04240	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CWI35_04255	COG0336	Belongs to the RNA methyltransferase TrmD family
CWI35_04260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CWI35_04270	COG1837	Belongs to the UPF0109 family
CWI35_04275	COG0228	four-way junction DNA binding
CWI35_04280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CWI35_04285	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CWI35_04290	COG0552	protein localization to endoplasmic reticulum
CWI35_04295	COG1196	nuclear chromosome segregation
CWI35_04305	COG0571	ribonuclease III activity
CWI35_04310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWI35_04315	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_04320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CWI35_04325	COG0416	fatty acid biosynthetic process
CWI35_04330	COG2050	protein possibly involved in aromatic compounds catabolism
CWI35_04330	COG1349	DNA-binding transcription factor activity
CWI35_04335	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CWI35_04340	COG1760	l-serine dehydratase
CWI35_04345	COG1760	l-serine dehydratase
CWI35_04350	COG1461	Dihydroxyacetone kinase
CWI35_04355	COG1302	Protein conserved in bacteria
CWI35_04360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CWI35_04370	COG1564	THIamine pyrophosphokinase
CWI35_04375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CWI35_04380	COG1162	GTPase activity
CWI35_04385	COG0515	serine threonine protein kinase
CWI35_04385	COG2815	serine threonine protein kinase
CWI35_04390	COG0631	protein serine/threonine phosphatase activity
CWI35_04395	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CWI35_04400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWI35_04400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWI35_04405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CWI35_04410	COG0242	peptide deformylase activity
CWI35_04415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CWI35_04420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CWI35_04425	COG1758	RNA polymerase activity
CWI35_04430	COG0194	GDP metabolic process
CWI35_04435	COG2052	Domain of unknown function (DUF370)
CWI35_04440	COG1561	YicC-like family, N-terminal region
CWI35_04445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CWI35_04480	COG0284	orotidine-5'-phosphate decarboxylase activity
CWI35_04485	COG0167	dihydroorotate dehydrogenase activity
CWI35_04505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CWI35_04510	COG0540	Belongs to the ATCase OTCase family
CWI35_04525	COG0564	pseudouridine synthase activity
CWI35_04530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CWI35_04535	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CWI35_04540	COG3599	regulation of cell shape
CWI35_04545	COG2302	S4 RNA-binding domain
CWI35_04550	COG0762	integral membrane protein
CWI35_04555	COG1799	cell septum assembly
CWI35_04560	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CWI35_04570	COG1873	PFAM PRC-barrel domain
CWI35_04575	COG1191	sigma factor activity
CWI35_04580	COG1191	sigma factor activity
CWI35_04590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CWI35_04595	COG0849	cell division
CWI35_04600	COG3856	small basic protein
CWI35_04605	COG3879	Bacterial protein of unknown function (DUF881)
CWI35_04610	COG3879	Bacterial protein of unknown function (DUF881)
CWI35_04615	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CWI35_04620	COG0772	Belongs to the SEDS family
CWI35_04625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CWI35_04630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWI35_04640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CWI35_04645	COG0768	penicillin binding
CWI35_04655	COG4839	cell division protein FtsL
CWI35_04660	COG0275	rRNA processing
CWI35_04665	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CWI35_04675	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CWI35_04685	COG1024	Enoyl-CoA hydratase
CWI35_04690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CWI35_04695	COG1399	metal-binding, possibly nucleic acid-binding protein
CWI35_04700	COG1323	Belongs to the UPF0348 family
CWI35_04705	COG3480	Lon protease (S16) C-terminal proteolytic domain
CWI35_04710	COG1752	Esterase of the alpha-beta hydrolase superfamily
CWI35_04715	COG3314	Sporulation integral membrane protein YlbJ
CWI35_04720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CWI35_04725	COG0742	ribosomal rna small subunit methyltransferase
CWI35_04740	COG4471	UPF0298 protein
CWI35_04745	COG3679	Belongs to the UPF0342 family
CWI35_04765	COG2340	Cysteine-rich secretory protein family
CWI35_04770	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CWI35_04790	COG3336	cytochrome c oxidase
CWI35_04815	COG0109	protoheme IX farnesyltransferase activity
CWI35_04820	COG1612	heme a metabolic process
CWI35_04825	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CWI35_04830	COG0772	Belongs to the SEDS family
CWI35_04835	COG4838	Belongs to the UPF0358 family
CWI35_04840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CWI35_04845	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CWI35_04855	COG4896	Protein conserved in bacteria
CWI35_04885	COG0483	inositol monophosphate 1-phosphatase activity
CWI35_04900	COG1982	Orn Lys Arg decarboxylase major
CWI35_04945	COG0561	phosphatase activity
CWI35_04955	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CWI35_04960	COG0569	domain protein
CWI35_04970	COG1473	amidohydrolase
CWI35_04975	COG2171	N-acyltransferase activity
CWI35_04980	COG0517	IMP dehydrogenase activity
CWI35_04995	COG2200	EAL domain
CWI35_05000	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_05005	COG1408	metallophosphoesterase
CWI35_05025	COG3706	GGDEF domain
CWI35_05035	COG0598	Magnesium transport protein CorA
CWI35_05045	COG0436	Aminotransferase
CWI35_05075	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_05080	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_05090	COG2084	Dehydrogenase
CWI35_05095	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_05105	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWI35_05110	COG0567	Dehydrogenase, E1 component
CWI35_05120	COG0840	transmembrane signaling receptor activity
CWI35_05130	COG0456	acetyltransferase
CWI35_05150	COG1263	PTS System
CWI35_05150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWI35_05150	COG2190	(PTS) system
CWI35_05155	COG3711	transcriptional antiterminator
CWI35_05160	COG0596	Alpha beta hydrolase
CWI35_05165	COG0475	glutathione-regulated potassium exporter activity
CWI35_05170	COG4191	Histidine kinase
CWI35_05180	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_05195	COG3773	Cell wall hydrolase
CWI35_05200	COG4873	Protein conserved in bacteria
CWI35_05205	COG0702	epimerase
CWI35_05210	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CWI35_05220	COG0720	synthase
CWI35_05225	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CWI35_05245	COG0840	transmembrane signaling receptor activity
CWI35_05250	COG3949	Membrane
CWI35_05260	COG0542	response to heat
CWI35_05295	COG1131	(ABC) transporter
CWI35_05325	COG0531	amino acid
CWI35_05330	COG0823	Involved in the tonB-independent uptake of proteins
CWI35_05330	COG4946	Tricorn protease homolog
CWI35_05330	COG1506	peptidase
CWI35_05340	COG4869	propanediol catabolic process
CWI35_05345	COG1846	Transcriptional regulator
CWI35_05355	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CWI35_05360	COG0235	Class ii aldolase
CWI35_05365	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CWI35_05370	COG1850	ribulose-bisphosphate carboxylase activity
CWI35_05375	COG0436	Aminotransferase
CWI35_05380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CWI35_05385	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CWI35_05390	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CWI35_05395	COG1879	ABC-type sugar transport system periplasmic component
CWI35_05400	COG1129	ABC transporter
CWI35_05405	COG4214	carbohydrate transport
CWI35_05410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CWI35_05415	COG5002	protein histidine kinase activity
CWI35_05430	COG2814	Major facilitator Superfamily
CWI35_05465	COG0531	amino acid
CWI35_05470	COG3162	membrane
CWI35_05475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWI35_05550	COG4948	Mandelate Racemase Muconate Lactonizing
CWI35_05560	COG1473	amidohydrolase
CWI35_05570	COG2966	Psort location CytoplasmicMembrane, score
CWI35_05595	COG0675	Transposase, IS605 OrfB family
CWI35_05615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CWI35_05640	COG1418	mRNA catabolic process
CWI35_05650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWI35_05655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWI35_05660	COG0367	asparagine synthase
CWI35_05665	COG4990	cell redox homeostasis
CWI35_05690	COG2217	Heavy metal translocating P-type atpase
CWI35_05695	COG1937	Protein conserved in bacteria
CWI35_05705	COG2723	6-phospho-beta-galactosidase activity
CWI35_05725	COG2801	Transposase and inactivated derivatives
CWI35_05745	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CWI35_05750	COG0697	spore germination
CWI35_05755	COG0693	protein deglycase activity
CWI35_05805	COG3328	transposase activity
CWI35_05835	COG0582	viral genome integration into host DNA
CWI35_05855	COG3437	response regulator, receiver
CWI35_05855	COG2770	Histidine kinase
CWI35_05860	COG0626	cystathionine gamma-synthase activity
CWI35_05865	COG0626	cystathionine gamma-synthase activity
CWI35_05870	COG2382	esterase
CWI35_05875	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CWI35_05880	COG2153	protein acetylation
CWI35_05900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWI35_05905	COG2323	membrane
CWI35_05920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CWI35_05995	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CWI35_06000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWI35_06005	COG0438	transferase activity, transferring glycosyl groups
CWI35_06010	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CWI35_06015	COG0438	transferase activity, transferring glycosyl groups
CWI35_06030	COG0772	Belongs to the SEDS family
CWI35_06035	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CWI35_06040	COG0564	pseudouridine synthase activity
CWI35_06045	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CWI35_06050	COG2357	RelA SpoT domain protein
CWI35_06060	COG4116	CYTH
CWI35_06065	COG0741	lytic transglycosylase activity
CWI35_06070	COG2346	COG2346, Truncated hemoglobins
CWI35_06085	COG1164	Oligoendopeptidase f
CWI35_06095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWI35_06100	COG4862	establishment of competence for transformation
CWI35_06105	COG0861	Integral membrane protein TerC family
CWI35_06110	COG1393	Belongs to the ArsC family
CWI35_06120	COG4608	Belongs to the ABC transporter superfamily
CWI35_06125	COG0444	Belongs to the ABC transporter superfamily
CWI35_06130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWI35_06135	COG0601	transmembrane transport
CWI35_06140	COG4166	transmembrane transport
CWI35_06165	COG5504	Zn-dependent protease
CWI35_06170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CWI35_06175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CWI35_06185	COG2267	carboxylic ester hydrolase activity
CWI35_06230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CWI35_06235	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CWI35_06240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CWI35_06245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CWI35_06265	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CWI35_06270	COG0314	molybdopterin synthase activity
CWI35_06275	COG1763	Mo-molybdopterin cofactor biosynthetic process
CWI35_06280	COG0303	'Molybdopterin
CWI35_06285	COG0840	transmembrane signaling receptor activity
CWI35_06285	COG3290	protein histidine kinase activity
CWI35_06295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CWI35_06300	COG4149	molybdate abc transporter
CWI35_06305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CWI35_06315	COG2223	nitrite transmembrane transporter activity
CWI35_06345	COG0535	radical SAM domain protein
CWI35_06355	COG0746	molybdenum cofactor guanylyltransferase activity
CWI35_06385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CWI35_06405	COG2151	metal-sulfur cluster biosynthetic enzyme
CWI35_06410	COG1073	alpha beta
CWI35_06415	COG0561	phosphatase activity
CWI35_06425	COG1307	EDD domain protein, DegV family
CWI35_06440	COG1666	GTP binding
CWI35_06460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWI35_06465	COG4555	ABC transporter
CWI35_06495	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_06500	COG2204	response regulator
CWI35_06520	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CWI35_06525	COG1177	transmembrane transport
CWI35_06530	COG1176	ABC-type spermidine putrescine transport system, permease component I
CWI35_06535	COG3842	ATPase activity
CWI35_06540	COG4133	protoheme IX ABC transporter activity
CWI35_06565	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CWI35_06565	COG0646	methionine synthase
CWI35_06570	COG0646	methionine synthase
CWI35_06570	COG1410	methionine synthase
CWI35_06590	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_06615	COG0366	Alpha amylase catalytic
CWI35_06620	COG3833	ABC-type maltose transport systems, permease component
CWI35_06625	COG1175	transmembrane transport
CWI35_06630	COG2182	Extracellular solute-binding protein
CWI35_06645	COG1917	Cupin 2, conserved barrel domain protein
CWI35_06645	COG2207	Transcriptional regulator
CWI35_06650	COG0534	Mate efflux family protein
CWI35_06660	COG0367	asparagine synthase
CWI35_06680	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWI35_06690	COG2311	Membrane
CWI35_06695	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_06745	COG0419	ATPase involved in DNA repair
CWI35_06750	COG0420	3'-5' exonuclease activity
CWI35_06755	COG1074	ATP-dependent DNA helicase activity
CWI35_06760	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CWI35_06770	COG0398	Pfam SNARE associated Golgi protein
CWI35_06775	COG4903	ComK protein
CWI35_06785	COG2224	Isocitrate lyase
CWI35_06800	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CWI35_06810	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CWI35_06825	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_06830	COG1234	tRNA 3'-trailer cleavage
CWI35_06840	COG1511	domain protein
CWI35_06845	COG1309	transcriptional regulator
CWI35_06860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CWI35_06865	COG3069	C4-dicarboxylate transmembrane transporter activity
CWI35_06870	COG4473	ABC transporter
CWI35_06875	COG1131	(ABC) transporter
CWI35_06890	COG0537	adenosine 5'-monophosphoramidase activity
CWI35_06895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWI35_06915	COG1846	Transcriptional regulator
CWI35_06930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CWI35_06945	COG3481	metal-dependent phosphohydrolase, HD sub domain
CWI35_06950	COG1668	transmembrane transport
CWI35_06955	COG4152	abc transporter atp-binding protein
CWI35_06965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CWI35_06970	COG0561	phosphatase activity
CWI35_06975	COG3679	Belongs to the UPF0342 family
CWI35_06980	COG4399	Belongs to the UPF0754 family
CWI35_06990	COG0189	ligase activity
CWI35_06995	COG0189	ligase activity
CWI35_07015	COG2508	Transcriptional regulator
CWI35_07020	COG3842	ATPase activity
CWI35_07035	COG1253	flavin adenine dinucleotide binding
CWI35_07060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CWI35_07065	COG2022	thiamine diphosphate biosynthetic process
CWI35_07075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWI35_07080	COG0352	thiamine-phosphate diphosphorylase activity
CWI35_07085	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CWI35_07090	COG1122	ATPase activity
CWI35_07095	COG4721	ABC-type cobalt transport system, permease component
CWI35_07100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CWI35_07110	COG2814	Major facilitator Superfamily
CWI35_07120	COG2318	DinB family
CWI35_07125	COG0366	Alpha amylase catalytic
CWI35_07130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CWI35_07135	COG2879	small protein
CWI35_07140	COG1966	Carbon starvation protein
CWI35_07155	COG0861	Integral membrane protein TerC family
CWI35_07165	COG2076	Multidrug Resistance protein
CWI35_07175	COG1294	oxidase, subunit
CWI35_07180	COG1271	oxidase subunit
CWI35_07210	COG0210	DNA helicase
CWI35_07250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CWI35_07260	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CWI35_07260	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CWI35_07270	COG1247	-acetyltransferase
CWI35_07275	COG2226	methyltransferase
CWI35_07285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CWI35_07290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWI35_07295	COG0798	PFAM Bile acid sodium symporter
CWI35_07300	COG0640	Transcriptional regulator
CWI35_07325	COG2072	flavoprotein involved in K transport
CWI35_07335	COG0640	Transcriptional regulator
CWI35_07345	COG1937	Protein conserved in bacteria
CWI35_07350	COG0534	Mate efflux family protein
CWI35_07410	COG2719	SpoVR family
CWI35_07415	COG0586	Pfam SNARE associated Golgi protein
CWI35_07430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWI35_07435	COG0517	IMP dehydrogenase activity
CWI35_07440	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CWI35_07460	COG0564	pseudouridine synthase activity
CWI35_07465	COG1253	flavin adenine dinucleotide binding
CWI35_07470	COG2738	Putative neutral zinc metallopeptidase
CWI35_07475	COG0656	L-ascorbic acid biosynthetic process
CWI35_07480	COG1301	dicarboxylic acid transport
CWI35_07485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CWI35_07490	COG3290	protein histidine kinase activity
CWI35_07515	COG2766	serine protein kinase
CWI35_07535	COG3382	B3 4 domain protein
CWI35_07670	COG0735	belongs to the Fur family
CWI35_07675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CWI35_07685	COG0039	L-malate dehydrogenase activity
CWI35_07700	COG4555	ABC transporter
CWI35_07705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CWI35_07710	COG4129	membrane
CWI35_07725	COG0747	negative chemotaxis
CWI35_07730	COG4608	Belongs to the ABC transporter superfamily
CWI35_07735	COG0444	Belongs to the ABC transporter superfamily
CWI35_07740	COG3557	Belongs to the UPF0374 family
CWI35_07755	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_07775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CWI35_07780	COG5609	conserved protein (DUF2294)
CWI35_07785	COG3383	formate dehydrogenase (NAD+) activity
CWI35_07790	COG2427	Protein of unknown function (DUF1641)
CWI35_07795	COG1988	membrane-bound metal-dependent
CWI35_07815	COG2137	regulation of response to DNA damage stimulus
CWI35_07820	COG1090	epimerase
CWI35_07840	COG1442	glycosyl transferase family 8
CWI35_07845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWI35_07850	COG1960	acyl-CoA dehydrogenase activity
CWI35_07860	COG3002	Belongs to the UPF0753 family
CWI35_07865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWI35_07870	COG5609	conserved protein (DUF2294)
CWI35_07885	COG0789	Transcriptional regulator
CWI35_07895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CWI35_07905	COG2197	response regulator
CWI35_07910	COG4585	Histidine kinase
CWI35_07915	COG4758	membrane
CWI35_07935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWI35_07940	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CWI35_07955	COG0535	radical SAM domain protein
CWI35_07965	COG0387	Pfam Sodium calcium exchanger
CWI35_07970	COG0477	Major facilitator Superfamily
CWI35_07980	COG1295	ribonuclease BN
CWI35_07985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWI35_07990	COG4840	Belongs to the UPF0435 family
CWI35_07995	COG0175	sulfate reduction
CWI35_08005	COG2046	Belongs to the sulfate adenylyltransferase family
CWI35_08010	COG0529	Catalyzes the synthesis of activated sulfate
CWI35_08025	COG1254	Belongs to the acylphosphatase family
CWI35_08035	COG0010	Belongs to the arginase family
CWI35_08040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CWI35_08060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CWI35_08060	COG1648	precorrin-2 dehydrogenase activity
CWI35_08075	COG5001	Diguanylate cyclase
CWI35_08075	COG3300	MHYT domain
CWI35_08080	COG1388	LysM domain
CWI35_08080	COG0791	NLP P60 protein
CWI35_08085	COG1077	Cell shape determining protein MreB Mrl
CWI35_08090	COG1620	l-lactate permease
CWI35_08095	COG2186	Transcriptional regulator
CWI35_08100	COG0247	lactate metabolic process
CWI35_08105	COG1139	Iron-sulfur cluster binding protein
CWI35_08110	COG1556	Lactate utilization protein
CWI35_08155	COG0861	Integral membrane protein TerC family
CWI35_08160	COG2986	histidine ammonia-lyase
CWI35_08185	COG0243	molybdopterin cofactor binding
CWI35_08195	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CWI35_08200	COG2068	MobA-Related Protein
CWI35_08205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CWI35_08220	COG2814	Major facilitator Superfamily
CWI35_08230	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_08235	COG0028	Belongs to the TPP enzyme family
CWI35_08240	COG0436	Aminotransferase
CWI35_08250	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CWI35_08260	COG1714	RDD family
CWI35_08265	COG2208	phosphoserine phosphatase activity
CWI35_08270	COG1366	Belongs to the anti-sigma-factor antagonist family
CWI35_08280	COG2197	response regulator
CWI35_08295	COG0297	glycogen (starch) synthase activity
CWI35_08300	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CWI35_08305	COG0673	inositol 2-dehydrogenase activity
CWI35_08310	COG4326	sporulation control protein
CWI35_08315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWI35_08320	COG1959	2 iron, 2 sulfur cluster binding
CWI35_08360	COG2801	Transposase and inactivated derivatives
CWI35_08395	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CWI35_08397	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CWI35_08410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWI35_08415	COG1597	lipid kinase activity
CWI35_08420	COG2268	Band 7 protein
CWI35_08455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWI35_08465	COG5002	protein histidine kinase activity
CWI35_08470	COG1511	domain protein
CWI35_08560	COG0789	Transcriptional regulator
CWI35_08570	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CWI35_08575	COG1518	maintenance of DNA repeat elements
CWI35_08645	COG1732	Glycine betaine
CWI35_08650	COG1125	glycine betaine transport
CWI35_08650	COG0517	IMP dehydrogenase activity
CWI35_08655	COG1174	glycine betaine transport
CWI35_08680	COG5002	protein histidine kinase activity
CWI35_08750	COG1131	(ABC) transporter
CWI35_08795	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CWI35_08800	COG0154	amidase activity
CWI35_08805	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CWI35_08825	COG1231	oxidoreductase activity
CWI35_08830	COG1611	Belongs to the LOG family
CWI35_08835	COG4851	CamS sex pheromone cAM373 precursor
CWI35_08840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CWI35_08850	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CWI35_08855	COG4496	protein, YerC YecD
CWI35_08860	COG1470	cell adhesion involved in biofilm formation
CWI35_08865	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CWI35_08875	COG0151	Belongs to the GarS family
CWI35_08880	COG0138	bifunctional purine biosynthesis protein purh
CWI35_08885	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CWI35_08890	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CWI35_08895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CWI35_08900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CWI35_08905	COG0047	phosphoribosylformylglycinamidine synthase activity
CWI35_08910	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CWI35_08915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CWI35_08920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CWI35_08925	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CWI35_08930	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CWI35_08955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CWI35_08960	COG2252	PERMEase
CWI35_08965	COG0519	Catalyzes the synthesis of GMP from XMP
CWI35_08965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CWI35_08975	COG1305	Transglutaminase-like
CWI35_08980	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CWI35_08985	COG0714	Associated with various cellular activities
CWI35_08990	COG1914	H( )-stimulated, divalent metal cation uptake system
CWI35_08995	COG0114	fumarate hydratase activity
CWI35_09030	COG0459	protein refolding
CWI35_09035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CWI35_09040	COG1266	CAAX protease self-immunity
CWI35_09055	COG0805	protein transport
CWI35_09060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWI35_09065	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CWI35_09070	COG0315	cyclic pyranopterin monophosphate synthase activity
CWI35_09075	COG0488	(ABC) transporter
CWI35_09085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CWI35_09090	COG0456	acetyltransferase
CWI35_09095	COG1214	PFAM Peptidase M22, glycoprotease
CWI35_09100	COG0802	atpase or kinase
CWI35_09175	COG3091	SprT-like family
CWI35_09185	COG2183	response to ionizing radiation
CWI35_09190	COG2337	Toxic component of a toxin-antitoxin (TA) module
CWI35_09195	COG0864	Transcriptional regulator
CWI35_09200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CWI35_09205	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CWI35_09210	COG0736	holo-[acyl-carrier-protein] synthase activity
CWI35_09215	COG0705	Rhomboid family
CWI35_09220	COG0513	Belongs to the DEAD box helicase family
CWI35_09230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CWI35_09235	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWI35_09240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CWI35_09245	COG0586	Pfam SNARE associated Golgi protein
CWI35_09255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CWI35_09260	COG1968	undecaprenyl-diphosphatase activity
CWI35_09265	COG1940	carbohydrate kinase activity
CWI35_09270	COG5577	PFAM Coat F domain
CWI35_09285	COG1971	Probably functions as a manganese efflux pump
CWI35_09300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CWI35_09305	COG1368	sulfuric ester hydrolase activity
CWI35_09310	COG1404	Belongs to the peptidase S8 family
CWI35_09330	COG1131	(ABC) transporter
CWI35_09340	COG2197	response regulator
CWI35_09350	COG2318	DinB family
CWI35_09355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CWI35_09385	COG1960	acyl-CoA dehydrogenase activity
CWI35_09390	COG3290	protein histidine kinase activity
CWI35_09390	COG3829	transcription factor binding
CWI35_09395	COG1120	ATPase activity
CWI35_09420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWI35_09425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWI35_09430	COG0586	Pfam SNARE associated Golgi protein
CWI35_09435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CWI35_09440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CWI35_09445	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_09455	COG3829	transcription factor binding
CWI35_09480	COG2318	DinB family
CWI35_09485	COG3739	integral membrane protein
CWI35_09490	COG3655	Transcriptional regulator
CWI35_09510	COG4174	ABC transporter (Permease)
CWI35_09520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CWI35_09520	COG0426	domain, Protein
CWI35_09530	COG3328	transposase activity
CWI35_09535	COG0180	Tryptophanyl-tRNA synthetase
CWI35_09575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CWI35_09580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWI35_09585	COG4856	YbbR-like protein
CWI35_09590	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CWI35_09595	COG5662	AntiSigma factor
CWI35_09600	COG1595	DNA-templated transcription, initiation
CWI35_09660	COG0726	polysaccharide deacetylase
CWI35_09665	COG2194	sulfuric ester hydrolase activity
CWI35_09675	COG0489	protein tyrosine kinase activity
CWI35_09680	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWI35_09690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CWI35_09695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CWI35_09700	COG0101	tRNA pseudouridine synthase activity
CWI35_09705	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CWI35_09710	COG1122	ATPase activity
CWI35_09715	COG1122	ATPase activity
CWI35_09720	COG0203	ribosomal protein L17
CWI35_09725	COG0202	RNA polymerase activity
CWI35_09730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CWI35_09735	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CWI35_09740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWI35_09745	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CWI35_09750	COG0024	Methionine aminopeptidase
CWI35_09755	COG0563	adenylate kinase activity
CWI35_09760	COG0201	protein transport
CWI35_09765	COG0200	Binds to the 23S rRNA
CWI35_09770	COG1841	ribosomal large subunit assembly
CWI35_09775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CWI35_09780	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CWI35_09785	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CWI35_09790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CWI35_09795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CWI35_09800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CWI35_09805	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CWI35_09810	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CWI35_09815	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CWI35_09820	COG0255	Belongs to the universal ribosomal protein uL29 family
CWI35_09825	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CWI35_09830	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CWI35_09835	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CWI35_09840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CWI35_09845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CWI35_09850	COG0089	rRNA binding
CWI35_09855	COG0088	Forms part of the polypeptide exit tunnel
CWI35_09860	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CWI35_09865	COG0051	transcription antitermination factor activity, RNA binding
CWI35_09875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWI35_09880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CWI35_09885	COG0049	tRNA binding
CWI35_09890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CWI35_09895	COG1358	cellular component organization or biogenesis
CWI35_09900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CWI35_09905	COG0085	RNA polymerase activity
CWI35_09925	COG2813	Specifically methylates the guanine in position
CWI35_09930	COG0222	ribosome binding
CWI35_09935	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CWI35_09940	COG0081	regulation of translation
CWI35_09945	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CWI35_09950	COG0250	Participates in transcription elongation, termination and antitermination
CWI35_09955	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CWI35_09960	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWI35_09970	COG3688	RNA-binding protein containing a PIN domain
CWI35_09975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWI35_09985	COG0215	cysteine-tRNA ligase activity
CWI35_09990	COG1045	serine acetyltransferase
CWI35_09995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CWI35_10000	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CWI35_10005	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CWI35_10010	COG4956	integral membrane protein (PIN domain superfamily)
CWI35_10015	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CWI35_10020	COG0542	response to heat
CWI35_10025	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CWI35_10030	COG3880	PFAM UvrB UvrC protein
CWI35_10105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CWI35_10110	COG1396	sequence-specific DNA binding
CWI35_10115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CWI35_10120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CWI35_10125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CWI35_10130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWI35_10135	COG0512	Glutamine amidotransferase of anthranilate synthase
CWI35_10140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CWI35_10145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CWI35_10150	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CWI35_10155	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CWI35_10160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CWI35_10170	COG0037	tRNA processing
CWI35_10175	COG0515	serine threonine protein kinase
CWI35_10180	COG2304	oxidoreductase activity
CWI35_10185	COG2208	phosphoserine phosphatase activity
CWI35_10205	COG1098	S1 RNA binding domain
CWI35_10230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CWI35_10235	COG3956	TIGRFAM MazG family protein
CWI35_10240	COG2244	polysaccharide biosynthetic process
CWI35_10245	COG2002	toxin-antitoxin pair type II binding
CWI35_10250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CWI35_10260	COG0193	aminoacyl-tRNA hydrolase activity
CWI35_10265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CWI35_10275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CWI35_10280	COG2088	sporulation resulting in formation of a cellular spore
CWI35_10285	COG0251	oxidation-reduction process
CWI35_10290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWI35_10295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CWI35_10310	COG4466	Protein conserved in bacteria
CWI35_10320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CWI35_10330	COG3584	3D domain protein
CWI35_10330	COG3583	domain protein
CWI35_10335	COG0084	hydrolase, TatD family'
CWI35_10345	COG2002	toxin-antitoxin pair type II binding
CWI35_10350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CWI35_10355	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CWI35_10360	COG4467	Involved in initiation control of chromosome replication
CWI35_10365	COG1774	PSP1 C-terminal conserved region
CWI35_10370	COG0470	DNA polymerase III
CWI35_10375	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CWI35_10380	COG1982	Orn Lys Arg decarboxylase major
CWI35_10430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CWI35_10435	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CWI35_10440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CWI35_10450	COG0590	tRNA wobble adenosine to inosine editing
CWI35_10455	COG1388	LysM domain
CWI35_10455	COG3858	chitin binding
CWI35_10460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CWI35_10465	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CWI35_10470	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CWI35_10480	COG0517	IMP dehydrogenase activity
CWI35_10480	COG0516	GMP reductase activity
CWI35_10515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CWI35_10520	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWI35_10525	COG0187	DNA topoisomerase II activity
CWI35_10530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWI35_10540	COG0592	DNA-directed DNA polymerase activity
CWI35_10545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWI35_10550	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CWI35_10555	COG0594	ribonuclease P activity
CWI35_10560	COG0706	membrane insertase activity
CWI35_10565	COG1847	R3H domain protein
CWI35_10575	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CWI35_10580	COG0445	tRNA wobble uridine modification
CWI35_10585	COG0357	Ribosomal RNA small subunit methyltransferase G
CWI35_10590	COG1475	DNA binding
CWI35_10595	COG1192	Involved in chromosome partitioning
CWI35_10600	COG1475	DNA binding
CWI35_10615	COG0668	transmembrane transport
CWI35_10620	COG4481	Protein conserved in bacteria
CWI35_10625	COG0243	molybdopterin cofactor binding
CWI35_10630	COG0012	GTP binding
CWI35_10635	COG0360	Binds together with S18 to 16S ribosomal RNA
CWI35_10640	COG0629	single-stranded DNA binding
CWI35_10645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CWI35_10650	COG4241	membrane
CWI35_10655	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CWI35_10660	COG0359	binds to the 23S rRNA
CWI35_10665	COG0305	Participates in initiation and elongation during chromosome replication
CWI35_10670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CWI35_10675	COG0745	RESPONSE REGULATOR receiver
CWI35_10680	COG5002	protein histidine kinase activity
CWI35_10685	COG4863	YycH protein
CWI35_10690	COG4853	Protein conserved in bacteria
CWI35_10695	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CWI35_10700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWI35_10710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CWI35_10715	COG2199	diguanylate cyclase activity
CWI35_10720	COG1929	Belongs to the glycerate kinase type-1 family
CWI35_10730	COG1482	cell wall glycoprotein biosynthetic process
CWI35_10735	COG0723	plastoquinol--plastocyanin reductase activity
CWI35_10735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWI35_10745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWI35_10755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CWI35_10760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CWI35_10770	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CWI35_10790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWI35_10795	COG3153	acetyltransferase
CWI35_10795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CWI35_10800	COG0351	phosphomethylpyrimidine kinase
CWI35_10805	COG4636	protein conserved in cyanobacteria
CWI35_10810	COG0686	Belongs to the AlaDH PNT family
CWI35_10815	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CWI35_10815	COG2508	Transcriptional regulator
CWI35_10820	COG0473	3-isopropylmalate dehydrogenase activity
CWI35_10825	COG2190	(PTS) system
CWI35_10830	COG3711	transcriptional antiterminator
CWI35_10835	COG1263	PTS System
CWI35_10835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWI35_10840	COG1621	beta-fructofuranosidase activity
CWI35_10850	COG0581	inorganic phosphate transmembrane transporter activity
CWI35_10855	COG0573	inorganic phosphate transmembrane transporter activity
CWI35_10860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CWI35_10875	COG0477	Major facilitator Superfamily
CWI35_10880	COG1216	Glycosyl transferase, family 2
CWI35_10885	COG0423	glycine-tRNA ligase activity
CWI35_10895	COG2208	phosphoserine phosphatase activity
CWI35_10900	COG1191	sigma factor activity
CWI35_10905	COG2172	sigma factor antagonist activity
CWI35_10915	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CWI35_10925	COG2363	Small membrane protein
CWI35_10935	COG3773	Cell wall hydrolase
CWI35_10945	COG0280	phosphate acetyltransferase
CWI35_10955	COG0095	Lipoate-protein ligase
CWI35_10965	COG4844	belongs to the
CWI35_10970	COG1078	dGTPase activity
CWI35_10975	COG3465	dGTPase activity
CWI35_10980	COG2252	PERMEase
CWI35_10985	COG1942	4-Oxalocrotonate Tautomerase
CWI35_10990	COG1994	Peptidase M50
CWI35_11000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWI35_11005	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CWI35_11010	COG0010	Belongs to the arginase family
CWI35_11025	COG0018	arginyl-trna synthetase
CWI35_11035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWI35_11040	COG2181	nitrate reductase activity
CWI35_11040	COG0247	lactate metabolic process
CWI35_11045	COG0183	Belongs to the thiolase family
CWI35_11055	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWI35_11060	COG1960	acyl-CoA dehydrogenase activity
CWI35_11065	COG1960	acyl-CoA dehydrogenase activity
CWI35_11075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CWI35_11075	COG1703	isobutyryl-CoA mutase activity
CWI35_11075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CWI35_11080	COG3343	RNA polymerase activity
CWI35_11085	COG0504	CTP synthase activity
CWI35_11090	COG4821	SIS domain
CWI35_11095	COG2204	response regulator
CWI35_11105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CWI35_11110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWI35_11115	COG1494	fructose-1,6-bisphosphatase
CWI35_11120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CWI35_11125	COG0254	rRNA binding
CWI35_11130	COG1435	thymidine kinase activity
CWI35_11145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CWI35_11160	COG0009	L-threonylcarbamoyladenylate synthase
CWI35_11170	COG1971	Probably functions as a manganese efflux pump
CWI35_11180	COG0840	transmembrane signaling receptor activity
CWI35_11185	COG0698	ribose 5-phosphate isomerase
CWI35_11190	COG4475	Protein of unknown function (DUF436)
CWI35_11195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CWI35_11200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CWI35_11220	COG0356	it plays a direct role in the translocation of protons across the membrane
CWI35_11230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CWI35_11235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CWI35_11240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CWI35_11245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CWI35_11250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CWI35_11255	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CWI35_11260	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWI35_11265	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWI35_11270	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWI35_11275	COG0649	NAD binding
CWI35_11280	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CWI35_11285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWI35_11290	COG0839	Belongs to the complex I subunit 6 family
CWI35_11295	COG0713	ATP synthesis coupled electron transport
CWI35_11300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWI35_11310	COG1007	ATP synthesis coupled electron transport
CWI35_11320	COG4836	Membrane
CWI35_11330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWI35_11335	COG2385	sporulation resulting in formation of a cellular spore
CWI35_11340	COG0739	heme binding
CWI35_11345	COG1522	sequence-specific DNA binding
CWI35_11360	COG0747	negative chemotaxis
CWI35_11365	COG0444	Belongs to the ABC transporter superfamily
CWI35_11370	COG4608	Belongs to the ABC transporter superfamily
CWI35_11380	COG2059	Chromate
CWI35_11385	COG2059	Chromate
CWI35_11400	COG1609	Transcriptional regulator
CWI35_11405	COG1077	Cell shape determining protein MreB Mrl
CWI35_11410	COG4786	Flagellar basal body rod
CWI35_11415	COG4786	Flagellar basal body rod
CWI35_11425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CWI35_11435	COG1316	TRANSCRIPTIONal
CWI35_11515	COG1376	ErfK ybiS ycfS ynhG family protein
CWI35_11530	COG0697	spore germination
CWI35_11550	COG0395	ABC-type sugar transport system, permease component
CWI35_11555	COG1175	transmembrane transport
CWI35_11575	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CWI35_11580	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CWI35_11595	COG3189	MarR family transcriptional regulator
CWI35_11600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CWI35_11600	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CWI35_11610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWI35_11620	COG3012	SEC-C Motif Domain Protein
CWI35_11620	COG1405	negative regulation of cell septum assembly
CWI35_11635	COG3012	SEC-C Motif Domain Protein
CWI35_11635	COG1405	negative regulation of cell septum assembly
CWI35_11645	COG0653	protein targeting
CWI35_11655	COG0653	protein targeting
CWI35_11660	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWI35_11665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CWI35_11690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWI35_11710	COG1609	Transcriptional regulator
CWI35_11715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWI35_11730	COG0640	Transcriptional regulator
CWI35_11740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWI35_11750	COG0673	inositol 2-dehydrogenase activity
CWI35_11755	COG0346	lactoylglutathione lyase activity
CWI35_11780	COG0277	FAD linked oxidase domain protein
CWI35_11790	COG1486	melibiose metabolic process
CWI35_11805	COG2972	Histidine kinase
CWI35_11810	COG2207	Transcriptional regulator
CWI35_11810	COG4753	response regulator
CWI35_11820	COG1175	transmembrane transport
CWI35_11845	COG2011	ABC-type metal ion transport system permease component
CWI35_11850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CWI35_11855	COG1960	acyl-CoA dehydrogenase activity
CWI35_11865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWI35_11870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWI35_11880	COG0583	DNA-binding transcription factor activity
CWI35_11885	COG0431	NADPH-dependent FMN reductase
CWI35_11890	COG1940	carbohydrate kinase activity
CWI35_11895	COG1309	transcriptional regulator
CWI35_11900	COG0477	Major facilitator Superfamily
CWI35_11910	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_11930	COG0527	aspartate kinase activity
CWI35_11940	COG3764	Sortase (surface protein transpeptidase)
CWI35_11950	COG0629	single-stranded DNA binding
CWI35_11965	COG0791	NLP P60 protein
CWI35_11965	COG1388	LysM domain
CWI35_11975	COG0544	peptidyl-prolyl cis-trans isomerase activity
CWI35_12010	COG3344	reverse transcriptase
CWI35_12020	COG0737	Belongs to the 5'-nucleotidase family
CWI35_12060	COG3409	Peptidoglycan-binding domain 1 protein
CWI35_12060	COG0793	Belongs to the peptidase S41A family
CWI35_12070	COG0653	protein targeting
CWI35_12075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWI35_12090	COG0673	inositol 2-dehydrogenase activity
CWI35_12125	COG0438	transferase activity, transferring glycosyl groups
CWI35_12140	COG2247	cell wall binding repeat
CWI35_12140	COG2385	sporulation resulting in formation of a cellular spore
CWI35_12150	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWI35_12155	COG1316	TRANSCRIPTIONal
CWI35_12160	COG1739	Uncharacterized protein family UPF0029
CWI35_12165	COG4585	Histidine kinase
CWI35_12170	COG2197	response regulator
CWI35_12175	COG1307	EDD domain protein, DegV family
CWI35_12185	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CWI35_12190	COG1040	competence protein
CWI35_12210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CWI35_12215	COG1728	Protein conserved in bacteria
CWI35_12235	COG4786	Flagellar basal body rod
CWI35_12235	COG1256	bacterial-type flagellum assembly
CWI35_12240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CWI35_12250	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CWI35_12255	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CWI35_12260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CWI35_12270	COG1086	Polysaccharide biosynthesis protein
CWI35_12290	COG0297	glycogen (starch) synthase activity
CWI35_12290	COG0438	transferase activity, transferring glycosyl groups
CWI35_12305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CWI35_12310	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CWI35_12320	COG2089	acid synthase
CWI35_12325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWI35_12330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CWI35_12350	COG1334	flagellar protein FlaG
CWI35_12355	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CWI35_12360	COG1516	flagellar protein fliS
CWI35_12390	COG0653	protein targeting
CWI35_12410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWI35_12430	COG2884	Cell division ATP-binding protein ftsE
CWI35_12435	COG2177	Part of the ABC transporter FtsEX involved in
CWI35_12440	COG0739	heme binding
CWI35_12475	COG1741	Belongs to the pirin family
CWI35_12490	COG0793	Belongs to the peptidase S41A family
CWI35_12490	COG3409	Peptidoglycan-binding domain 1 protein
CWI35_12495	COG0463	Glycosyl transferase, family 2
CWI35_12505	COG0789	Transcriptional regulator
CWI35_12510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWI35_12515	COG4897	Protein conserved in bacteria
CWI35_12520	COG0556	nucleotide-excision repair
CWI35_12525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CWI35_12535	COG1950	PFAM Membrane protein of
CWI35_12540	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CWI35_12545	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CWI35_12550	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CWI35_12555	COG0546	phosphoglycolate phosphatase activity
CWI35_12560	COG0110	maltose O-acetyltransferase activity
CWI35_12565	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CWI35_12570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CWI35_12580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CWI35_12585	COG0131	Imidazoleglycerol-phosphate dehydratase
CWI35_12590	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CWI35_12595	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CWI35_12600	COG0107	imidazoleglycerol-phosphate synthase activity
CWI35_12605	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CWI35_12605	COG0140	phosphoribosyl-ATP diphosphatase activity
CWI35_12620	COG0492	ferredoxin-NADP+ reductase activity
CWI35_12625	COG1051	belongs to the nudix hydrolase family
CWI35_12630	COG1660	Displays ATPase and GTPase activities
CWI35_12635	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CWI35_12640	COG1481	regulation of sporulation
CWI35_12645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWI35_12650	COG0740	serine-type endopeptidase activity
CWI35_12670	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CWI35_12690	COG0126	phosphoglycerate kinase activity
CWI35_12695	COG0149	triose-phosphate isomerase activity
CWI35_12700	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CWI35_12705	COG0148	phosphopyruvate hydratase activity
CWI35_12725	COG2272	Belongs to the type-B carboxylesterase lipase family
CWI35_12740	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CWI35_12750	COG0557	exoribonuclease II activity
CWI35_12755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CWI35_12820	COG2197	response regulator
CWI35_12835	COG3546	catalase activity
CWI35_12840	COG0583	DNA-binding transcription factor activity
CWI35_12855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWI35_12875	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_12890	COG0559	Belongs to the binding-protein-dependent transport system permease family
CWI35_12920	COG0469	pyruvate kinase activity
CWI35_12930	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CWI35_12935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CWI35_12945	COG5577	PFAM Coat F domain
CWI35_12955	COG0506	proline dehydrogenase activity
CWI35_12965	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWI35_12965	COG1024	Enoyl-CoA hydratase
CWI35_12970	COG0183	Belongs to the thiolase family
CWI35_12975	COG1960	acyl-CoA dehydrogenase activity
CWI35_12980	COG1393	Belongs to the ArsC family
CWI35_12985	COG0509	glycine decarboxylation via glycine cleavage system
CWI35_12995	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CWI35_13000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWI35_13010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CWI35_13015	COG2011	ABC-type metal ion transport system permease component
CWI35_13020	COG1464	Belongs to the NlpA lipoprotein family
CWI35_13030	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CWI35_13035	COG0396	ATPase activity
CWI35_13040	COG0719	Fe-S assembly protein
CWI35_13045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CWI35_13050	COG0822	iron-sulfur transferase activity
CWI35_13055	COG0719	Fe-S assembly protein
CWI35_13060	COG1280	lysine exporter protein (LysE YggA)
CWI35_13065	COG1801	Protein of unknown function DUF72
CWI35_13070	COG0730	response to heat
CWI35_13075	COG0737	Belongs to the 5'-nucleotidase family
CWI35_13080	COG3377	Domain of unknown function (DUF1805)
CWI35_13105	COG0411	ABC transporter
CWI35_13120	COG0739	heme binding
CWI35_13125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CWI35_13135	COG4470	Protein conserved in bacteria
CWI35_13150	COG2445	Protein of unknown function DUF86
CWI35_13155	COG0647	UMP catabolic process
CWI35_13160	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CWI35_13165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CWI35_13175	COG0460	homoserine dehydrogenase
CWI35_13180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CWI35_13190	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CWI35_13195	COG4837	Protein of unknown function (DUF1462)
CWI35_13200	COG1252	NADH dehydrogenase
CWI35_13205	COG4844	belongs to the
CWI35_13210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CWI35_13215	COG0316	Belongs to the HesB IscA family
CWI35_13220	COG5416	Lipopolysaccharide assembly protein A domain
CWI35_13225	COG0492	ferredoxin-NADP+ reductase activity
CWI35_13230	COG1252	NADH dehydrogenase
CWI35_13245	COG3584	3D domain protein
CWI35_13255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CWI35_13260	COG1392	Phosphate transport regulator
CWI35_13265	COG0306	phosphate transporter
CWI35_13300	COG3316	Transposase and inactivated derivatives
CWI35_13320	COG3328	transposase activity
CWI35_13355	COG2814	Major facilitator Superfamily
CWI35_13450	COG5018	Exonuclease
CWI35_13460	COG2032	superoxide dismutase activity
CWI35_13465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CWI35_13475	COG1522	sequence-specific DNA binding
CWI35_13480	COG0436	Aminotransferase
CWI35_13485	COG1098	S1 RNA binding domain
CWI35_13490	COG2155	Conserved Protein
CWI35_13495	COG1979	alcohol dehydrogenase
CWI35_13500	COG0166	Belongs to the GPI family
CWI35_13510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CWI35_13520	COG2814	Major facilitator Superfamily
CWI35_13525	COG1247	-acetyltransferase
CWI35_13550	COG1285	pathogenesis
CWI35_13745	COG0384	phenazine biosynthesis protein PhzF
CWI35_13805	COG1280	lysine exporter protein (LysE YggA)
CWI35_13820	COG3279	Response regulator of the LytR AlgR family
CWI35_13825	COG0427	acetyl-CoA hydrolase
CWI35_13840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CWI35_13845	COG1575	Belongs to the MenA family. Type 1 subfamily
CWI35_13850	COG1169	isochorismate synthase
CWI35_13855	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CWI35_13860	COG0596	Alpha beta hydrolase
CWI35_13865	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CWI35_13870	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_13910	COG0523	cobalamin synthesis protein
CWI35_13915	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CWI35_13920	COG1854	S-ribosylhomocysteine lyase activity
CWI35_13930	COG0783	Belongs to the Dps family
CWI35_13935	COG4824	toxin secretion phage lysis holin
CWI35_13945	COG0494	nUDIX hydrolase
CWI35_13950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWI35_13955	COG1116	anion transmembrane transporter activity
CWI35_13960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWI35_13965	COG1506	peptidase
CWI35_13985	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CWI35_13990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CWI35_13995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CWI35_14005	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CWI35_14020	COG2814	Major facilitator Superfamily
CWI35_14025	COG0495	leucyl-tRNA aminoacylation
CWI35_14030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWI35_14065	COG2081	HI0933 family
CWI35_14070	COG2244	polysaccharide biosynthetic process
CWI35_14080	COG1187	pseudouridine synthase activity
CWI35_14085	COG1349	DNA-binding transcription factor activity
CWI35_14090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWI35_14110	COG1523	belongs to the glycosyl hydrolase 13 family
CWI35_14115	COG0510	thiamine kinase activity
CWI35_14125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CWI35_14130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWI35_14140	COG1363	Peptidase, m42
CWI35_14145	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CWI35_14150	COG4848	Belongs to the UPF0354 family
CWI35_14155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWI35_14160	COG1674	ftsk spoiiie
CWI35_14165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CWI35_14180	COG3118	belongs to the thioredoxin family
CWI35_14185	COG1605	Chorismate mutase
CWI35_14185	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CWI35_14195	COG0123	including yeast histone deacetylase and acetoin utilization protein
CWI35_14200	COG0517	IMP dehydrogenase activity
CWI35_14205	COG0454	-acetyltransferase
CWI35_14210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWI35_14215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWI35_14230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CWI35_14235	COG2199	diguanylate cyclase activity
CWI35_14235	COG2203	Gaf domain
CWI35_14240	COG1956	GAF domain-containing protein
CWI35_14245	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CWI35_14250	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CWI35_14260	COG1104	cysteine desulfurase activity
CWI35_14265	COG0301	tRNA thio-modification
CWI35_14275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWI35_14280	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CWI35_14285	COG0616	signal peptide processing
CWI35_14290	COG1714	RDD family
CWI35_14300	COG3874	Sporulation protein YtfJ
CWI35_14305	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CWI35_14310	COG0827	DNA restriction-modification system
CWI35_14315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CWI35_14335	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_14340	COG1960	acyl-CoA dehydrogenase activity
CWI35_14345	COG1960	acyl-CoA dehydrogenase activity
CWI35_14350	COG1024	Enoyl-CoA hydratase
CWI35_14355	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_14385	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_14390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWI35_14400	COG2197	response regulator
CWI35_14405	COG0521	Mo-molybdopterin cofactor biosynthetic process
CWI35_14410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWI35_14420	COG0137	argininosuccinate synthase activity
CWI35_14425	COG0165	Argininosuccinate lyase
CWI35_14430	COG0589	response to stress
CWI35_14435	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_14445	COG0006	proline dipeptidase activity
CWI35_14450	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CWI35_14455	COG4109	DRTGG domain
CWI35_14465	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CWI35_14480	COG0587	DNA-directed DNA polymerase activity
CWI35_14490	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CWI35_14495	COG0825	malonyl-CoA metabolic process
CWI35_14500	COG0205	6-phosphofructokinase activity
CWI35_14510	COG0628	permease
CWI35_14515	COG2707	UPF0756 membrane protein
CWI35_14520	COG0372	Belongs to the citrate synthase family
CWI35_14525	COG0538	isocitrate dehydrogenase activity
CWI35_14530	COG0039	L-malate dehydrogenase activity
CWI35_14545	COG0745	RESPONSE REGULATOR receiver
CWI35_14550	COG5002	protein histidine kinase activity
CWI35_14560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CWI35_14565	COG0237	dephospho-CoA kinase activity
CWI35_14570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CWI35_14575	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CWI35_14585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CWI35_14590	COG3611	Membrane attachment protein
CWI35_14595	COG1484	DNA-dependent DNA replication
CWI35_14615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CWI35_14625	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CWI35_14630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CWI35_14635	COG3326	Membrane
CWI35_14645	COG1363	Peptidase, m42
CWI35_14675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWI35_14680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWI35_14685	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CWI35_14690	COG0072	phenylalanine-tRNA ligase activity
CWI35_14690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWI35_14695	COG1910	domain protein
CWI35_14700	COG0725	ABC transporter, periplasmic molybdate-binding protein
CWI35_14705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CWI35_14710	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CWI35_14720	COG1785	Belongs to the alkaline phosphatase family
CWI35_14725	COG1846	Transcriptional regulator
CWI35_14730	COG2409	Drug exporters of the RND superfamily
CWI35_14730	COG1033	growth of symbiont in host cell
CWI35_14740	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CWI35_14745	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CWI35_14750	COG1286	toxin biosynthetic process
CWI35_14755	COG1796	DNA polymerase
CWI35_14755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CWI35_14760	COG1193	negative regulation of DNA recombination
CWI35_14765	COG3766	membrane
CWI35_14770	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_14775	COG1309	transcriptional regulator
CWI35_14780	COG1024	Enoyl-CoA hydratase
CWI35_14785	COG2086	electron transfer activity
CWI35_14790	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CWI35_14795	COG3118	belongs to the thioredoxin family
CWI35_14800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWI35_14805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWI35_14810	COG1116	anion transmembrane transporter activity
CWI35_14815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWI35_14820	COG0431	NADPH-dependent FMN reductase
CWI35_14825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWI35_14835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWI35_14850	COG0463	Glycosyl transferase, family 2
CWI35_14870	COG0322	excinuclease ABC activity
CWI35_14875	COG1719	4-vinyl reductase, 4VR
CWI35_14880	COG2009	succinate dehydrogenase
CWI35_14885	COG1053	succinate dehydrogenase
CWI35_14890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CWI35_14895	COG2197	response regulator
CWI35_14900	COG1846	Transcriptional regulator
CWI35_14905	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CWI35_14910	COG5401	PFAM Sporulation and spore germination
CWI35_14915	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CWI35_14920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CWI35_14925	COG0622	Phosphoesterase
CWI35_14930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWI35_14940	COG0028	Belongs to the TPP enzyme family
CWI35_14945	COG0440	acetolactate synthase activity
CWI35_14950	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CWI35_14955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWI35_14960	COG0473	3-isopropylmalate dehydrogenase activity
CWI35_14965	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CWI35_14970	COG0066	3-isopropylmalate dehydratase activity
CWI35_14980	COG0544	peptidyl-prolyl cis-trans isomerase activity
CWI35_14985	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CWI35_14990	COG1067	ATP-dependent peptidase activity
CWI35_14990	COG0470	DNA polymerase III
CWI35_14995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CWI35_15000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CWI35_15010	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CWI35_15015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CWI35_15020	COG0181	hydroxymethylbilane synthase activity
CWI35_15025	COG1587	Uroporphyrinogen-III synthase
CWI35_15030	COG0113	porphobilinogen synthase activity
CWI35_15035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CWI35_15040	COG1388	LysM domain
CWI35_15040	COG1388	LysM domain
CWI35_15055	COG0525	valine-tRNA ligase activity
CWI35_15060	COG0285	dihydrofolate synthase activity
CWI35_15065	COG5492	domain, Protein
CWI35_15070	COG3344	reverse transcriptase
CWI35_15105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CWI35_15125	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CWI35_15165	COG0424	maF-like protein
CWI35_15170	COG2003	Belongs to the UPF0758 family
CWI35_15175	COG1077	Cell shape determining protein MreB Mrl
CWI35_15180	COG1792	Involved in formation and maintenance of cell shape
CWI35_15190	COG0850	regulation of cytokinetic process
CWI35_15195	COG2894	cell division
CWI35_15205	COG0739	heme binding
CWI35_15210	COG1994	Peptidase M50
CWI35_15215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CWI35_15220	COG2868	ribosomal protein
CWI35_15225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CWI35_15230	COG3290	protein histidine kinase activity
CWI35_15235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CWI35_15240	COG4492	Belongs to the UPF0735 family
CWI35_15245	COG0077	Prephenate dehydratase
CWI35_15250	COG1827	regulation of RNA biosynthetic process
CWI35_15255	COG1104	cysteine desulfurase activity
CWI35_15260	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CWI35_15265	COG0157	Belongs to the NadC ModD family
CWI35_15270	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CWI35_15275	COG1388	LysM domain
CWI35_15285	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CWI35_15295	COG0217	transcriptional regulatory protein
CWI35_15305	COG0632	four-way junction helicase activity
CWI35_15310	COG2255	four-way junction helicase activity
CWI35_15325	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CWI35_15330	COG0343	queuine tRNA-ribosyltransferase activity
CWI35_15335	COG1862	Preprotein translocase
CWI35_15345	COG2244	polysaccharide biosynthetic process
CWI35_15355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWI35_15355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWI35_15360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CWI35_15365	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CWI35_15365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CWI35_15370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWI35_15375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CWI35_15380	COG1490	D-aminoacyl-tRNA deacylase activity
CWI35_15385	COG0450	alkyl hydroperoxide reductase
CWI35_15390	COG3634	alkyl hydroperoxide reductase activity
CWI35_15395	COG0124	histidyl-tRNA synthetase
CWI35_15400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CWI35_15410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CWI35_15420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWI35_15425	COG1309	transcriptional regulator
CWI35_15430	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CWI35_15435	COG2364	Membrane
CWI35_15440	COG1959	2 iron, 2 sulfur cluster binding
CWI35_15445	COG1104	cysteine desulfurase activity
CWI35_15450	COG0482	sulfurtransferase activity
CWI35_15460	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CWI35_15480	COG0628	permease
CWI35_15485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CWI35_15490	COG4472	Bacterial protein of unknown function (DUF965)
CWI35_15495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CWI35_15500	COG3906	Belongs to the UPF0473 family
CWI35_15505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CWI35_15525	COG0572	uridine kinase
CWI35_15530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWI35_15535	COG0768	penicillin binding
CWI35_15550	COG2226	methyltransferase
CWI35_15555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CWI35_15565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CWI35_15570	COG0626	cystathionine gamma-synthase activity
CWI35_15605	COG1396	sequence-specific DNA binding
CWI35_15710	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CWI35_15725	COG0586	Pfam SNARE associated Golgi protein
CWI35_15735	COG1360	Flagellar Motor Protein
CWI35_15740	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CWI35_15745	COG1183	phosphatidylcholine synthase activity
CWI35_15750	COG0688	phosphatidylethanolamine metabolic process
CWI35_15760	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CWI35_15765	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CWI35_15770	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CWI35_15775	COG1534	Rna-binding protein
CWI35_15780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CWI35_15785	COG1713	HD superfamily hydrolase involved in NAD metabolism
CWI35_15790	COG0799	negative regulation of ribosome biogenesis
CWI35_15795	COG2226	methyltransferase
CWI35_15800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CWI35_15805	COG1596	polysaccharide export
CWI35_15805	COG1555	photosystem II stabilization
CWI35_15810	COG2131	deaminase
CWI35_15815	COG0658	competence protein
CWI35_15815	COG2333	competence protein COMEC
CWI35_15825	COG1466	dna polymerase III delta subunit
CWI35_15830	COG0268	Binds directly to 16S ribosomal RNA
CWI35_15835	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CWI35_15840	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWI35_15855	COG0481	GTPase activity
CWI35_15860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CWI35_15865	COG1420	regulation of RNA biosynthetic process
CWI35_15870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CWI35_15875	COG0443	Heat shock 70 kDa protein
CWI35_15880	COG0484	heat shock protein binding
CWI35_15885	COG2264	protein methyltransferase activity
CWI35_15890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CWI35_15895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWI35_15900	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CWI35_15905	COG1283	sodium-dependent phosphate transmembrane transporter activity
CWI35_15910	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CWI35_15915	COG1610	YqeY-like protein
CWI35_15930	COG1702	phosphate starvation-inducible protein PhoH
CWI35_15935	COG1480	7TM receptor with intracellular HD hydrolase
CWI35_15940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CWI35_15945	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CWI35_15950	COG0295	cytidine deaminase activity
CWI35_15955	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CWI35_15965	COG1381	Involved in DNA repair and RecF pathway recombination
CWI35_15970	COG0517	IMP dehydrogenase activity
CWI35_15975	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CWI35_15985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CWI35_15995	COG2010	Cytochrome c
CWI35_16000	COG2384	SAM-dependent methyltransferase
CWI35_16005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CWI35_16010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CWI35_16025	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CWI35_16040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWI35_16045	COG1121	(ABC) transporter
CWI35_16050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CWI35_16055	COG0735	belongs to the Fur family
CWI35_16060	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CWI35_16065	COG4709	membrane
CWI35_16070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CWI35_16075	COG1388	LysM domain
CWI35_16085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CWI35_16090	COG0573	inorganic phosphate transmembrane transporter activity
CWI35_16095	COG0581	inorganic phosphate transmembrane transporter activity
CWI35_16100	COG5521	maltodextrose utilization protein MalA
CWI35_16115	COG0477	Major facilitator Superfamily
CWI35_16125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CWI35_16150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CWI35_16165	COG0457	Tetratricopeptide repeat
CWI35_16165	COG0705	Rhomboid family
CWI35_16175	COG0697	spore germination
CWI35_16180	COG4483	Protein conserved in bacteria
CWI35_16185	COG1940	carbohydrate kinase activity
CWI35_16200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWI35_16220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CWI35_16225	COG1459	type II secretion system
CWI35_16230	COG4537	Required for transformation and DNA binding
CWI35_16265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWI35_16270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CWI35_16275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CWI35_16290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWI35_16295	COG0095	Lipoate-protein ligase
CWI35_16300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWI35_16305	COG1388	LysM domain
CWI35_16305	COG3858	chitin binding
CWI35_16335	COG1321	iron dependent repressor
CWI35_16340	COG1752	Esterase of the alpha-beta hydrolase superfamily
CWI35_16350	COG3872	metal-dependent enzyme
CWI35_16360	COG0006	proline dipeptidase activity
CWI35_16365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CWI35_16375	COG3854	ATPases associated with a variety of cellular activities
CWI35_16415	COG0511	ligase activity, forming carbon-carbon bonds
CWI35_16420	COG0439	Biotin carboxylase
CWI35_16425	COG1302	Protein conserved in bacteria
CWI35_16430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWI35_16435	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CWI35_16440	COG1570	exodeoxyribonuclease VII activity
CWI35_16445	COG1722	exodeoxyribonuclease VII activity
CWI35_16455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CWI35_16460	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CWI35_16465	COG1438	arginine binding
CWI35_16470	COG0497	DNA recombination
CWI35_16475	COG0750	zinc metalloprotease
CWI35_16485	COG3093	addiction module antidote protein HigA
CWI35_16490	COG0584	glycerophosphoryl diester phosphodiesterase
CWI35_16500	COG3290	protein histidine kinase activity
CWI35_16500	COG3829	transcription factor binding
CWI35_16505	COG0280	phosphate acetyltransferase
CWI35_16515	COG3426	butyrate kinase activity
CWI35_16520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWI35_16525	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CWI35_16530	COG0022	dehydrogenase e1 component
CWI35_16535	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWI35_16545	COG0745	RESPONSE REGULATOR receiver
CWI35_16550	COG5002	protein histidine kinase activity
CWI35_16570	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CWI35_16570	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CWI35_16575	COG1703	isobutyryl-CoA mutase activity
CWI35_16610	COG1131	(ABC) transporter
CWI35_16630	COG1131	(ABC) transporter
CWI35_16660	COG4129	membrane
CWI35_16665	COG1376	ErfK ybiS ycfS ynhG family protein
CWI35_16675	COG0346	lactoylglutathione lyase activity
CWI35_16680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CWI35_16690	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWI35_16705	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CWI35_16710	COG0577	efflux transmembrane transporter activity
CWI35_16715	COG1136	(ABC) transporter
CWI35_16720	COG0642	Histidine kinase
CWI35_16725	COG0745	RESPONSE REGULATOR receiver
CWI35_16745	COG2723	6-phospho-beta-galactosidase activity
CWI35_16750	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CWI35_16755	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CWI35_16760	COG1234	tRNA 3'-trailer cleavage
CWI35_16765	COG1902	pentaerythritol trinitrate reductase activity
CWI35_16770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CWI35_16775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWI35_16780	COG0300	oxidoreductase activity
CWI35_16810	COG2807	transmembrane transport
CWI35_16815	COG0667	Aldo Keto reductase
CWI35_16820	COG0494	nUDIX hydrolase
CWI35_16825	COG1379	DNA repair
CWI35_16830	COG1300	Membrane
CWI35_16835	COG0735	belongs to the Fur family
CWI35_16845	COG4974	Belongs to the 'phage' integrase family
CWI35_16850	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CWI35_16865	COG1686	Belongs to the peptidase S11 family
CWI35_16875	COG2172	sigma factor antagonist activity
CWI35_16900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CWI35_16915	COG0697	spore germination
CWI35_16920	COG0019	diaminopimelate decarboxylase activity
CWI35_16925	COG4086	secreted protein
CWI35_16930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CWI35_16935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CWI35_16935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CWI35_16940	COG0307	riboflavin synthase, alpha
CWI35_16945	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWI35_16945	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWI35_16950	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CWI35_16960	COG1547	Domain of unknown function (DUF309)
CWI35_16965	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CWI35_16970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CWI35_16980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CWI35_16985	COG1686	Belongs to the peptidase S11 family
CWI35_16990	COG2715	membrane protein required for spore maturation
CWI35_16995	COG0700	Nucleoside recognition
CWI35_17000	COG1187	pseudouridine synthase activity
CWI35_17005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWI35_17010	COG1333	cytochrome c biogenesis protein
CWI35_17015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CWI35_17020	COG0745	RESPONSE REGULATOR receiver
CWI35_17025	COG5002	protein histidine kinase activity
CWI35_17030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CWI35_17035	COG0363	glucosamine-6-phosphate deaminase activity
CWI35_17045	COG1263	PTS System
CWI35_17045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWI35_17055	COG3275	phosphorelay sensor kinase activity
CWI35_17060	COG3279	Response regulator of the LytR AlgR family
CWI35_17075	COG0531	amino acid
CWI35_17085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CWI35_17090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWI35_17095	COG1120	ATPase activity
CWI35_17100	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CWI35_17105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWI35_17110	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CWI35_17115	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CWI35_17130	COG2096	Adenosyltransferase
CWI35_17145	COG1595	DNA-templated transcription, initiation
CWI35_17155	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CWI35_17160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWI35_17185	COG4955	Helix-turn-helix domain
CWI35_17190	COG0514	ATP-dependent DNA helicase (RecQ)
CWI35_17210	COG3546	catalase activity
CWI35_17230	COG4862	establishment of competence for transformation
CWI35_17235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CWI35_17240	COG0492	ferredoxin-NADP+ reductase activity
CWI35_17250	COG2339	peptidase activity
CWI35_17255	COG3409	Peptidoglycan-binding domain 1 protein
CWI35_17255	COG3773	Cell wall hydrolase
CWI35_17260	COG2959	enzyme of heme biosynthesis
CWI35_17280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CWI35_17285	COG0204	Acyl-transferase
CWI35_17290	COG0539	negative regulation of cytoplasmic translation
CWI35_17315	COG1160	GTP binding
CWI35_17320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CWI35_17335	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CWI35_17350	COG0302	gtp cyclohydrolase
CWI35_17365	COG2226	methyltransferase
CWI35_17375	COG0105	UTP biosynthetic process
CWI35_17385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CWI35_17390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CWI35_17395	COG4401	Chorismate mutase type I
CWI35_17405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CWI35_17410	COG0134	indole-3-glycerol-phosphate synthase activity
CWI35_17415	COG0135	phosphoribosylanthranilate isomerase activity
CWI35_17425	COG0159	tryptophan synthase activity
CWI35_17430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWI35_17435	COG0287	Prephenate dehydrogenase
CWI35_17440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CWI35_17445	COG0457	Tetratricopeptide repeat
CWI35_17450	COG5582	Belongs to the UPF0302 family
CWI35_17485	COG4347	Protein of unknown function (DUF1405)
CWI35_17495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWI35_17500	COG1694	Mazg nucleotide pyrophosphohydrolase
CWI35_17505	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CWI35_17510	COG1803	Methylglyoxal synthase
CWI35_17515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CWI35_17520	COG0438	transferase activity, transferring glycosyl groups
CWI35_17525	COG0617	tRNA 3'-terminal CCA addition
CWI35_17540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CWI35_17545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CWI35_17550	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CWI35_17555	COG1199	ATP-dependent helicase activity
CWI35_17555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CWI35_17580	COG0017	Asparaginyl-tRNA synthetase
CWI35_17585	COG3935	DnaD domain protein
CWI35_17590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CWI35_17595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWI35_17595	COG4499	WXG100 protein secretion system (Wss), protein YukC
CWI35_17600	COG3331	DNA recombination
CWI35_17640	COG0745	RESPONSE REGULATOR receiver
CWI35_17645	COG5002	protein histidine kinase activity
CWI35_17650	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CWI35_17655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CWI35_17665	COG2217	Heavy metal translocating P-type atpase
CWI35_17670	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CWI35_17675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CWI35_17680	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CWI35_17685	COG1609	Transcriptional regulator
CWI35_17690	COG0071	Belongs to the small heat shock protein (HSP20) family
CWI35_17755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWI35_17760	COG2368	4-hydroxyphenylacetate
CWI35_17770	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_17790	COG4377	Putative membrane peptidase family (DUF2324)
CWI35_17805	COG0156	8-amino-7-oxononanoate synthase activity
CWI35_17830	COG2066	Belongs to the glutaminase family
CWI35_17845	COG2211	Major facilitator Superfamily
CWI35_17865	COG0673	inositol 2-dehydrogenase activity
CWI35_17870	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_17870	COG2030	dehydratase
CWI35_17885	COG1609	Transcriptional regulator
CWI35_17890	COG1653	transport
CWI35_17905	COG0673	inositol 2-dehydrogenase activity
CWI35_17915	COG0673	inositol 2-dehydrogenase activity
CWI35_17920	COG1082	Xylose isomerase domain protein TIM barrel
CWI35_17945	COG1061	Type III restriction enzyme res subunit
CWI35_17950	COG4336	lyase activity
CWI35_17970	COG0457	Tetratricopeptide repeat
CWI35_17970	COG0463	Glycosyl transferase, family 2
CWI35_17995	COG0658	competence protein
CWI35_17995	COG2333	competence protein COMEC
CWI35_18025	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CWI35_18060	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CWI35_18100	COG1876	peptidase activity
CWI35_18105	COG0582	viral genome integration into host DNA