locus-tag class description BS467_00040 ENOG4105G5W regulator Fur family BS467_00045 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BS467_00050 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BS467_00055 ENOG4107NBY Membrane BS467_00060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BS467_00065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BS467_00070 ENOG4105DEF Extracellular solute-binding protein, family 5 BS467_00075 ENOG4108JQ7 (ABC) transporter BS467_00080 ENOG4105C3U ABC transporter BS467_00085 ENOG4105BZ1 (ABC) transporter BS467_00090 ENOG4105EVI UPF0374 protein BS467_00105 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BS467_00110 ENOG4106BXE BS467_00115 ENOG4105CEN a g-specific adenine glycosylase BS467_00120 ENOG41067AE Membrane-bound metal-dependent hydrolase BS467_00130 ENOG4106DF4 Sigma-70, region 4 BS467_00140 ENOG4105F0F Oxalate decarboxylase BS467_00155 ENOG4105MSY salicylate hydroxylase BS467_00160 ENOG4105EJV Membrane BS467_00165 ENOG4105CKK Glycosyl transferase, family 2 BS467_00190 ENOG4105KC9 Modulates RecA activity (By similarity) BS467_00195 ENOG4105ECP epimerase BS467_00210 ENOG4107Y03 Nitroreductase BS467_00235 ENOG410834F Transcriptional regulator BS467_00245 ENOG4108YYS metal-dependent hydrolase (By similarity) BS467_00265 ENOG4105K6V RNA polymerase BS467_00270 ENOG4105KK4 UPF0060 membrane protein BS467_00280 ENOG4105BZ1 (ABC) transporter BS467_00285 ENOG4108HUF Transporter BS467_00300 ENOG4107TDE lipolytic protein G-D-S-L family BS467_00320 ENOG410839T multidrug resistance protein BS467_00375 ENOG4105C22 threonyL-tRNA synthetase BS467_00390 ENOG4108RWP Major Facilitator Superfamily protein BS467_00395 ENOG4107TXC Transcriptional regulator BS467_00410 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BS467_00425 ENOG4105D7N magnesium and cobalt transport protein CorA BS467_00450 ENOG4105D8X mechanosensitive ion channel BS467_00460 ENOG4105CDY transcriptional regulatory protein BS467_00475 ENOG4105UPD Calcium Proton BS467_00485 ENOG4108ISG Major Facilitator BS467_00490 ENOG4107U9T Pfam:Ribonuclease_BN BS467_00500 ENOG4105KJF protein tyrosine phosphatase BS467_00510 ENOG4105BZG amino acid carrier protein BS467_00520 ENOG4107RKG DJ-1/PfpI family BS467_00525 ENOG4105CGH 5'-nucleotidase BS467_00535 ENOG4107414 GntR family transcriptional regulator BS467_00540 ENOG4105CG3 alpha amylase, catalytic region BS467_00545 ENOG4105C5Y PTS System BS467_00560 ENOG4105DY8 decarboxylase BS467_00580 ENOG4105NX3 Membrane BS467_00590 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BS467_00600 ENOG4108RPX mosc domain containing protein BS467_00605 ENOG41084AG Acylphosphatase BS467_00620 ENOG4105U3E Transcriptional regulator BS467_00625 ENOG4105PY6 Phenolic acid decarboxylase BS467_00645 ENOG4108MRH transcriptional regulatory protein BS467_00660 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BS467_00670 ENOG4105E6M Sulphatase-modifying factor protein BS467_00675 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BS467_00695 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BS467_00700 ENOG4105FDU atp-dependent rna helicase BS467_00705 ENOG4105C5H ABC transporter BS467_00710 ENOG4105DXB Major Facilitator superfamily BS467_00715 ENOG4107SWG transcriptional regulator MERR family BS467_00720 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) BS467_00725 ENOG4105C5H ABC transporter BS467_00730 ENOG4107TVC Glycosyl transferase, family 2 BS467_00735 ENOG4105CUB amino acid BS467_00765 ENOG4105C8P )-transporter BS467_00770 ENOG4107RVG penicillin-binding protein BS467_00775 ENOG4105EU0 Major facilitator Superfamily BS467_00780 ENOG41090R9 glycosyltransferase BS467_00785 ENOG4107R51 Glycosyl transferase, family 2 BS467_00790 ENOG41090R9 glycosyltransferase BS467_00800 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BS467_00820 ENOG4108R1P BS467_00845 ENOG4105HX0 Transcriptional regulator BS467_00850 ENOG4105F8D glycoside hydrolase family 4 BS467_00865 ENOG4105C3M thioredoxin reductase BS467_00870 ENOG41062ES Transcriptional regulator BS467_00890 ENOG4105C79 DNA protecting protein DprA BS467_00905 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BS467_00910 ENOG4105CBD Diacylglycerol kinase BS467_00925 ENOG4108IG5 Transcriptional regulator BS467_00930 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BS467_00935 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BS467_00940 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BS467_00945 ENOG4105CK7 Sodium proline symporter BS467_00950 ENOG4105KT7 mgtC SapB transporter BS467_00955 ENOG4105CRN Aminoglycoside phosphotransferase BS467_00965 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BS467_00970 ENOG4105C4R Atp-dependent dna helicase BS467_00975 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) BS467_00990 ENOG4105CBC glutamate synthase BS467_01000 ENOG4105KGF protein, YerC YecD BS467_01015 ENOG4107S4Y M20 DapE family protein YgeY BS467_01030 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BS467_01055 ENOG4105C12 Phosphoribosylglycinamide synthetase BS467_01060 ENOG4105DC1 bifunctional purine biosynthesis protein purh BS467_01065 ENOG4108V3E phosphoribosylglycinamide formyltransferase BS467_01070 ENOG4105CXB phosphoribosylaminoimidazole synthetase BS467_01080 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BS467_01090 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BS467_01095 ENOG4105C8V SAICAR synthetase BS467_01100 ENOG4105C83 adenylosuccinate lyase BS467_01105 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BS467_01110 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BS467_01120 ENOG4108U5N UPF0316 protein BS467_01135 ENOG4105C7N Xanthine uracil vitamin C permease BS467_01140 ENOG4105GZI Transcriptional regulator BS467_01145 ENOG4108RWP Major Facilitator Superfamily protein BS467_01155 ENOG4105JVQ RNA Polymerase BS467_01165 ENOG4105KNA -acetyltransferase BS467_01190 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BS467_01195 ENOG4105W4W Transcriptional regulator BS467_01200 ENOG4108UIN ybak prolyl-trna synthetase associated region BS467_01205 ENOG4105C4R Atp-dependent dna helicase BS467_01210 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BS467_01225 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BS467_01240 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BS467_01250 ENOG4105C85 amino acid BS467_01255 ENOG4107STQ Multicopper oxidase BS467_01295 ENOG4108VXD carboxy-peptidase BS467_01305 ENOG4108U05 Transcriptional regulator BS467_01310 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BS467_01315 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BS467_01320 ENOG4108TYN CAAX amino terminal protease family protein BS467_01335 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BS467_01340 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BS467_01345 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BS467_01350 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BS467_01355 ENOG4105C5H ABC transporter BS467_01365 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BS467_01370 ENOG410801F ribosomal-protein-alanine acetyltransferase BS467_01375 ENOG41072GX Peptidase M22 Glycoprotease BS467_01380 ENOG4105K8N protein family UPF0079, ATPase BS467_01385 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BS467_01440 ENOG4108UMN azlc family BS467_01460 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BS467_01465 ENOG4108VP3 Lysine exporter protein (LysE YggA) BS467_01470 ENOG4108JCI Transcriptional regulator BS467_01485 ENOG4108TVJ Nitroreductase BS467_01490 ENOG41090MY MarR family Transcriptional regulator BS467_01495 ENOG4105NAE bifunctional deaminase-reductase domain protein BS467_01500 ENOG4105ST3 Transcriptional regulator BS467_01510 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase BS467_01515 ENOG4105VDT -acetyltransferase BS467_01570 ENOG4107RB3 L-asparaginase BS467_01580 ENOG4107GJV short-chain dehydrogenase reductase BS467_01595 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS467_01610 ENOG4105VUF Transcriptional regulator BS467_01615 ENOG4105DQ4 alcohol dehydrogenase BS467_01620 ENOG4108VJ1 Transcriptional regulator (CarD family BS467_01625 ENOG4105VEQ Cold shock protein BS467_01680 ENOG41064BQ Phosphatase BS467_01690 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BS467_01695 ENOG4105WN5 stage II sporulation protein BS467_01700 ENOG4107SGM protein serine threonine phosphatase BS467_01705 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BS467_01710 ENOG4105FUA antagonist BS467_01715 ENOG4107MMM Anti-sigma-factor antagonist BS467_01720 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BS467_01730 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BS467_01735 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BS467_01750 ENOG4105CKV Membrane BS467_01755 ENOG410905X membrane-flanked domain protein BS467_01760 ENOG4105C1J atp-dependent rna helicase BS467_01775 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BS467_01780 ENOG4105CPF Cell wall formation (By similarity) BS467_01785 ENOG4105SZ6 Thioredoxin BS467_01805 ENOG4105CJ1 ABC, transporter BS467_01815 ENOG4106F5Q Membrane BS467_01820 ENOG4107QJT sodium dicarboxylate symporter BS467_01825 ENOG4108MRH transcriptional regulatory protein BS467_01830 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BS467_01835 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BS467_01840 ENOG4105EU9 BS467_01845 ENOG4107BMA Transglycosylase associated protein BS467_01850 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BS467_01895 ENOG4105C0X amino acid BS467_01905 ENOG4107R8N Glycosyl transferase, family 2 BS467_01910 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BS467_01925 ENOG4105C9U ATP-dependent DNA helicase RecQ BS467_01930 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BS467_01935 ENOG410631K Membrane BS467_01940 ENOG4106AXJ AraC family transcriptional regulator BS467_01945 ENOG4105DRR Transcriptional regulator, GntR family BS467_01950 ENOG4105VCH membrane BS467_01970 ENOG410606W general stress protein BS467_01975 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BS467_01980 ENOG4105HMZ Methyltransferase BS467_01985 ENOG4105ETD TRANSCRIPTIONal BS467_01995 ENOG4105XJB lipolytic protein G-D-S-L family BS467_02000 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BS467_02005 ENOG4107258 Transcriptional regulator BS467_02015 ENOG4105P4J Allophanate hydrolase, subunit 1 BS467_02020 ENOG4105CFM UPF0317 protein BS467_02025 ENOG4105C5A transporter BS467_02030 ENOG4105E7W lamb ycsf family protein BS467_02040 ENOG4105X3H Excalibur domain protein BS467_02085 ENOG4105C8Q Methyl-accepting chemotaxis BS467_02090 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BS467_02105 ENOG4108T5E Copper resistance protein BS467_02110 ENOG4105KTB nuclear export factor GLE1 BS467_02115 ENOG4105DYS nad(p)h dehydrogenase (quinone) BS467_02120 ENOG4105C26 Dehydrogenase BS467_02125 ENOG4107QTZ amino acid BS467_02130 ENOG4108JPW Aminotransferase BS467_02140 ENOG4105EGI Transcriptional regulator BS467_02150 ENOG4105YVS arsR family transcriptional regulator BS467_02160 ENOG4105R8C Transcriptional regulator BS467_02170 ENOG4105CFH Aspartokinase BS467_02180 ENOG4105BZU Histidine kinase BS467_02185 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS467_02195 ENOG4108PGP mmge prpd family protein BS467_02200 ENOG4105CH2 amidohydrolase BS467_02210 ENOG4108HW4 amino acid AbC transporter BS467_02215 ENOG4105EAB amino acid AbC transporter BS467_02220 ENOG4108XSB acetyltransferase, (GNAT) family BS467_02225 ENOG4105CPU Monooxygenase BS467_02235 ENOG4105DUX Transporter BS467_02240 ENOG4108IQI permease BS467_02255 ENOG4105DRP amino acid AbC transporter BS467_02260 ENOG4105CDA abc transporter atp-binding protein BS467_02275 ENOG4105CGH 5'-nucleotidase BS467_02290 ENOG41086D8 Transcriptional regulator BS467_02305 ENOG4105SX7 Transporter BS467_02320 ENOG4108IUW ABC transporter BS467_02360 ENOG4105CEY Amp-dependent synthetase and ligase BS467_02370 ENOG4105F38 ABC transporter, permease BS467_02375 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BS467_02405 ENOG4105C8Q Methyl-accepting chemotaxis BS467_02415 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BS467_02425 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein BS467_02435 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein BS467_02440 ENOG4105E5Q amino acid AbC transporter BS467_02450 ENOG4107R5R arsenical pump membrane protein BS467_02455 ENOG4107YHD transcriptional regulator BS467_02460 ENOG4105C26 Dehydrogenase BS467_02470 ENOG410756H nucleotidyltransferase BS467_02480 ENOG4105I82 acetyl xylan esterase BS467_02485 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BS467_02490 ENOG4105C5Q Transcriptional regulator BS467_02495 ENOG41089UC methyltransferase, type 11 BS467_02500 ENOG41079KZ Major Facilitator Superfamily BS467_02505 ENOG4105ETE Transcriptional regulator (LacI family BS467_02510 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BS467_02515 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BS467_02520 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region BS467_02535 ENOG4105DJB Major Facilitator Superfamily BS467_02540 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BS467_02550 ENOG4105C7K acetolactate synthase BS467_02555 ENOG4105FF2 Type I DHQase BS467_02570 ENOG4107RMH nh(3)-dependent nad( ) synthetase BS467_02575 ENOG4105EIG urea carboxylase-associated protein 1 BS467_02615 ENOG4105TRI Hydrolase BS467_02640 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BS467_02670 ENOG4107SQ8 Glycine betaine BS467_02675 ENOG4108IJ7 Glycine betaine BS467_02685 ENOG4108TTB tellurium resistance protein BS467_02710 ENOG4107TS3 membrane protein, TerC BS467_02715 ENOG4106FN3 tellurium resistance protein BS467_02720 ENOG4106FN3 tellurium resistance protein BS467_02725 ENOG4108N0M stress protein BS467_02730 ENOG4105DEN Luciferase family BS467_02740 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BS467_02765 ENOG4108SDH ABC, transporter BS467_02770 ENOG4108IUW ABC transporter BS467_02775 ENOG4107Y7X LytTR BS467_02785 ENOG4107SET aldo keto reductase BS467_02795 ENOG4105BZU Histidine kinase BS467_02800 ENOG4105WH1 Two component transcriptional regulator luxr family BS467_02810 ENOG41060AI SEC-C motif BS467_02825 ENOG4105CSV Glutaminase BS467_02835 ENOG4105D74 hydrolase BS467_02845 ENOG4105CUB amino acid BS467_02855 ENOG41067TZ transcriptional regulator, MarR family BS467_02860 ENOG4105E2A Dehydrogenase BS467_02870 ENOG4105J7D transcriptional regulator BS467_02880 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BS467_02900 ENOG4105C2C drug resistance transporter, Bcr CflA BS467_02915 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BS467_02920 ENOG4108J5H Homocysteine s-methyltransferase BS467_02925 ENOG4108IQI permease BS467_02940 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BS467_02945 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein BS467_02950 ENOG4108YRF PTS System BS467_02955 ENOG4105DM4 PTS System BS467_02960 ENOG4105C8I hydrolase, family 38 BS467_02965 ENOG4105EVU fructokinase BS467_02970 ENOG4105EMD TRANSCRIPTIONal BS467_02985 ENOG4105CS2 ec 3.2.1.21 BS467_02990 ENOG4105C5Y PTS System BS467_02995 ENOG4105CID antiterminator BS467_03005 ENOG4107QTZ amino acid BS467_03010 ENOG4105C72 UPF0176 protein BS467_03015 ENOG4107SCQ Iron-containing alcohol dehydrogenase BS467_03025 ENOG4105EWC Purine nucleoside phosphorylase BS467_03050 ENOG4108SUT Major Facilitator Superfamily BS467_03055 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BS467_03060 ENOG41087NI Sulfite exporter TauE/SafE BS467_03065 ENOG4105VFE sira family BS467_03070 ENOG4107TPS domain protein BS467_03075 ENOG4105VFE sira family BS467_03085 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BS467_03090 ENOG4105XTG Pfam:DUF156 BS467_03105 ENOG4105WAB arsR family transcriptional regulator BS467_03120 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BS467_03135 ENOG4105C7Z Conserved Protein BS467_03150 ENOG4105CXY transporter BS467_03155 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BS467_03175 ENOG4105YA8 Transcriptional regulator BS467_03185 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BS467_03195 ENOG4105VZ8 Transcriptional regulator BS467_03300 ENOG4108WUZ (ABC) transporter BS467_03310 ENOG4105U3E Transcriptional regulator BS467_03315 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BS467_03320 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BS467_03330 ENOG4105DA5 (ABC) transporter BS467_03345 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BS467_03350 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BS467_03355 ENOG4107U5W ybbr family BS467_03360 ENOG4105C8B TIGR00159 family BS467_03370 ENOG4105EMN RNA polymerase sigma factor BS467_03405 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BS467_03425 ENOG4105D17 glycoside hydrolase, family 3 domain protein BS467_03430 ENOG4105EHZ conserved protein UCP016719 BS467_03440 ENOG4105CHH sulfate transporter BS467_03445 ENOG4105I03 Flagellin BS467_03475 ENOG4108NMV polysaccharide deacetylase BS467_03490 ENOG4105D1F ATP-binding protein BS467_03545 ENOG4108UJD 30S ribosomal protein S9 BS467_03550 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BS467_03555 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BS467_03560 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BS467_03565 ENOG4108JJB ABC transporter BS467_03570 ENOG4108JJB ABC transporter BS467_03575 ENOG4108ZT0 50S ribosomal protein l17 BS467_03580 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BS467_03585 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BS467_03590 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BS467_03600 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BS467_03610 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BS467_03615 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BS467_03620 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BS467_03625 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BS467_03630 ENOG4105VPB 50S ribosomal protein L30 BS467_03635 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BS467_03640 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BS467_03645 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BS467_03650 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BS467_03655 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BS467_03660 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BS467_03665 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BS467_03670 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BS467_03675 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BS467_03680 ENOG41082SA 50s ribosomal protein l29 BS467_03685 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BS467_03690 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BS467_03695 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BS467_03700 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BS467_03705 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BS467_03710 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BS467_03715 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BS467_03720 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BS467_03725 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BS467_03730 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BS467_03740 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BS467_03745 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BS467_03750 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BS467_03755 ENOG4105XPM ribosomal protein BS467_03760 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BS467_03765 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BS467_03770 ENOG4107Y49 methyltransferase BS467_03775 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BS467_03780 ENOG4108VZM 50s ribosomal protein L10 BS467_03785 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BS467_03790 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BS467_03795 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BS467_03815 ENOG4105M0M Tetracycline resistance protein BS467_03820 ENOG4105C2N RNA methyltransferase TrmH family group 3 BS467_03825 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) BS467_03830 ENOG4105C8N cysteinyl-tRNA synthetase BS467_03835 ENOG4105D7W serine acetyltransferase BS467_03840 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BS467_03845 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BS467_03850 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BS467_03855 ENOG4105CTP PilT protein domain protein BS467_03860 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BS467_03865 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BS467_03875 ENOG41066A3 ATP guanido phosphotransferase BS467_03880 ENOG4108Z0C Uvrb UvrC protein BS467_03965 ENOG4105CRK lysyL-tRNA synthetase BS467_03970 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BS467_03980 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BS467_03985 ENOG4105KRF dihydroneopterin aldolase BS467_03990 ENOG4105EEI dihydropteroate synthase BS467_03995 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BS467_04000 ENOG4105DDQ anthranilate synthase BS467_04005 ENOG4105CRQ synthase (Component I) BS467_04010 ENOG4105C6T cysteine synthase BS467_04015 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase BS467_04020 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BS467_04025 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BS467_04030 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BS467_04035 ENOG4108UGV hypoxanthine phosphoribosyltransferase BS467_04040 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BS467_04070 ENOG41060GV RNA binding s1 domain protein BS467_04085 ENOG4105VYY sporulation protein yabp BS467_04090 ENOG41082I2 s4 domain protein BS467_04095 ENOG4108IY2 MazG family BS467_04105 ENOG4108M14 stage v sporulation protein t BS467_04110 ENOG4108JA2 transcriptioN-repair coupling factor BS467_04120 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BS467_04125 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BS467_04130 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BS467_04135 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BS467_04145 ENOG4105KME endoribonuclease L-psp BS467_04150 ENOG4105DFT pur operon repressor BS467_04155 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BS467_04160 ENOG4105XEW small acid-soluble spore protein BS467_04165 ENOG4105W42 Veg protein BS467_04170 ENOG4105XFA sporulation peptidase YabG BS467_04180 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BS467_04190 ENOG41069ER domain protein BS467_04195 ENOG4105F8V Hydrolase, tatD family BS467_04200 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BS467_04210 ENOG4105KRN Transcriptional regulator, abrb family BS467_04215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BS467_04220 ENOG4105VC4 domain protein BS467_04225 ENOG41060K3 Methyltransferase BS467_04230 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) BS467_04235 ENOG4105MA4 psp1 domain protein BS467_04240 ENOG4105FA2 dna polymerase iii BS467_04245 ENOG4105XVJ Protein of unknown function (DUF327) BS467_04250 ENOG4105X0R protein from nitrogen regulatory protein P-II BS467_04255 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BS467_04260 ENOG4105CXN decarboxylase BS467_04265 ENOG4105CDW Resistance protein BS467_04305 ENOG41067KS pro-sigma K processing BS467_04315 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BS467_04320 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BS467_04325 ENOG4105C6E dna polymerase iii BS467_04335 ENOG4108Z6B deaminase BS467_04340 ENOG4105GTG Isochorismatase BS467_04345 ENOG4105VRS hydrolase family 18 BS467_04355 ENOG4105ZMH deoxynucleoside kinase BS467_04370 ENOG4105FKZ Methyl-accepting chemotaxis BS467_04375 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BS467_04385 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BS467_04390 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BS467_04395 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BS467_04405 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BS467_04440 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BS467_04445 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BS467_04455 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BS467_04460 ENOG410848D S4 domain protein YaaA BS467_04465 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BS467_04470 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BS467_04480 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BS467_04485 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BS467_04495 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BS467_04500 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BS467_04505 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BS467_04520 ENOG4107QJE Chromosome Partitioning Protein BS467_04525 ENOG4105FA0 parb-like partition protein BS467_04530 ENOG4108ZDA Sporulation protein YyaC BS467_04550 ENOG4105VDK protein, conserved in bacteria BS467_04555 ENOG4105C3G gtp-binding protein BS467_04560 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BS467_04565 ENOG4108UUM single-stranded DNA-binding protein BS467_04570 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BS467_04575 ENOG4108IJ8 ABC transporter BS467_04580 ENOG4105E90 ABC transporter BS467_04585 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BS467_04590 ENOG4105FBA Phospholipase Carboxylesterase BS467_04595 ENOG4105CS1 NAD(P)H quinone oxidoreductase BS467_04600 ENOG4105CH6 catalase BS467_04610 ENOG4105JVQ RNA Polymerase BS467_04615 ENOG4108P49 AntiSigma factor BS467_04620 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BS467_04625 ENOG4108XMW Membrane BS467_04630 ENOG4105BZR domain protein BS467_04635 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BS467_04640 ENOG4105DJ2 Major Facilitator Superfamily BS467_04650 ENOG4108SA1 esterase BS467_04660 ENOG410874W AraC family transcriptional regulator BS467_04665 ENOG4105NIV Esterase BS467_04675 ENOG4106K80 BS467_04680 ENOG4105CDU Replicative dna helicase BS467_04685 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BS467_04690 ENOG4106A3M Cytochrome p-450 BS467_04695 ENOG4105ST3 Transcriptional regulator BS467_04700 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BS467_04715 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BS467_04740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS467_04745 ENOG4105BZU Histidine kinase BS467_04760 ENOG4105Q2H domain protein BS467_04765 ENOG4105C0H protease BS467_04770 ENOG4105WQG acetyltransferase BS467_04790 ENOG4108V7D UPF0397 protein BS467_04800 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BS467_04810 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BS467_04825 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BS467_04840 ENOG4105DS0 Transcriptional regulator, Crp Fnr family BS467_04860 ENOG41080UQ Transcriptional regulator BS467_04865 ENOG4105JAB phenazine biosynthesis protein, phzf family BS467_04875 ENOG4108S3Y transcriptional regulator BS467_04880 ENOG4105C5Y PTS System BS467_04885 ENOG4105CS2 ec 3.2.1.21 BS467_04925 ENOG4105E2X shikimate dehydrogenase BS467_04940 ENOG4105ETE Transcriptional regulator (LacI family BS467_04945 ENOG4105C85 amino acid BS467_04960 ENOG4105M6F mutator MutT protein BS467_04985 ENOG4105C5Y PTS System BS467_04990 ENOG4105CS2 ec 3.2.1.21 BS467_04995 ENOG4105CID antiterminator BS467_05000 ENOG410780I phosphoprotein phosphatase activity BS467_05010 ENOG4105C19 ABC transporter BS467_05020 ENOG4107Y80 Major Facilitator superfamily BS467_05025 ENOG4105YA8 Transcriptional regulator BS467_05030 ENOG4107VHA regulatoR BS467_05035 ENOG4107QQ0 gntp family BS467_05040 ENOG4105BZW Glycerate kinase BS467_05045 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BS467_05050 ENOG4105CJ1 ABC, transporter BS467_05055 ENOG4108TU7 Inherit from COG: (ABC) transporter BS467_05065 ENOG4105D4T Citrate transporter BS467_05080 ENOG4105EG2 ABC transporter, permease BS467_05090 ENOG4107FKK extracellular solute-binding protein family 1 BS467_05100 ENOG4105DUM transcriptional regulator, lysR family BS467_05140 ENOG4106KNT transcriptional regulator BS467_05145 ENOG4105CMG Carbohydrate kinase BS467_05150 ENOG4105C6Z Gluconate BS467_05155 ENOG4105F1N DNA alkylation repair BS467_05165 ENOG4105FKZ Methyl-accepting chemotaxis BS467_05170 ENOG4105EE0 oxidoreductase BS467_05175 ENOG4105W1Y Transcriptional regulator BS467_05180 ENOG410667J hydrolase BS467_05190 ENOG4105HMZ Methyltransferase BS467_05195 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BS467_05200 ENOG4105DXI Major Facilitator superfamily BS467_05205 ENOG4105EXC Acyl-transferase BS467_05215 ENOG4107RHR regulatoR BS467_05220 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BS467_05225 ENOG4105D9N nucleoside BS467_05230 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BS467_05240 ENOG4105FS7 Transcriptional regulator BS467_05245 ENOG4108TVJ Nitroreductase BS467_05250 ENOG41067V3 Antibiotic biosynthesis monooxygenase BS467_05255 ENOG4107G87 m6 family metalloprotease domain protein BS467_05280 ENOG4105ETU transcriptional activator (TenA BS467_05285 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BS467_05290 ENOG4108JJB ABC transporter BS467_05295 ENOG4108W7F transporter, permease BS467_05305 ENOG4108XI2 Domain of unknown function (DUF1963) BS467_05310 ENOG4105CID antiterminator BS467_05315 ENOG4105C5Y PTS System BS467_05320 ENOG4105CS2 ec 3.2.1.21 BS467_05330 ENOG4105C6Z Gluconate BS467_05340 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BS467_05345 ENOG4106KNT transcriptional regulator BS467_05360 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BS467_05390 ENOG4108IMY Transcriptional regulator BS467_05395 ENOG4105HDK L-asparaginase BS467_05400 ENOG4108IJ0 Aspartate ammonia-lyase BS467_05405 ENOG4105DFD Na H antiporter BS467_05430 ENOG4105EMD TRANSCRIPTIONal BS467_05435 ENOG4105CK1 PTS System BS467_05440 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BS467_05445 ENOG4105CS2 ec 3.2.1.21 BS467_05450 ENOG4105VZJ PTS System BS467_05455 ENOG4105VCP PTS System BS467_05460 ENOG4107BJW polysaccharide deacetylase BS467_05470 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BS467_05475 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BS467_05480 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BS467_05485 ENOG4105KVH Transcriptional regulator BS467_05490 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BS467_05495 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BS467_05520 ENOG4105KFN sortase, SrtB family BS467_05525 ENOG4108HUF Transporter BS467_05530 ENOG4105DQ5 transport system permease protein BS467_05535 ENOG4105E0A ABC, transporter BS467_05540 ENOG4105C4M (Ubiquinol oxidase) subunit I BS467_05545 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BS467_05550 ENOG4108JJ9 ABC, transporter BS467_05555 ENOG4108JJ8 (ABC) transporter BS467_05560 ENOG4108J20 pectate lyase BS467_05580 ENOG4107R37 Glutamate dehydrogenase BS467_05595 ENOG4105EMD TRANSCRIPTIONal BS467_05600 ENOG4105VZJ PTS System BS467_05605 ENOG4105CK1 PTS System BS467_05610 ENOG4105VCP PTS System BS467_05615 ENOG4105F8D glycoside hydrolase family 4 BS467_05630 ENOG4105CM2 brancheD-chain amino acid aminotransferase BS467_05635 ENOG4108M26 parallel beta-helix repeat protein BS467_05640 ENOG4108QGH periplasmic BS467_05645 ENOG4105C2J ABC transporter BS467_05650 ENOG4105CNN ABC, transporter BS467_05665 ENOG4107R0W ABC transporter BS467_05670 ENOG4105E5Q amino acid AbC transporter BS467_05685 ENOG4105DR4 Methyltransferase BS467_05690 ENOG41067MG lrgb family BS467_05700 ENOG4105CMU LysR family (Transcriptional regulator BS467_05705 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BS467_05710 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BS467_05750 ENOG4105WH5 Teichoic acid glycosylation protein BS467_05765 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BS467_05770 ENOG4105CMR udp-glucose 4-epimerase BS467_05785 ENOG4105E2S oxidase) subunit II BS467_05790 ENOG4105BZ9 Cytochrome C oxidase, subunit I BS467_05795 ENOG4105CCU oxidase (Subunit III) BS467_05800 ENOG41060D1 Quinol oxidase BS467_05815 ENOG4108DBC nitroreductase BS467_05820 ENOG4105DEN Luciferase family BS467_05830 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BS467_05845 ENOG4105C5Y PTS System BS467_05865 ENOG4105DWF phosphomethylpyrimidine kinase BS467_05875 ENOG4108RJ9 Glycosyl transferase, family 2 BS467_05880 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BS467_05885 ENOG4105C26 Dehydrogenase BS467_05930 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BS467_05935 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD BS467_05945 ENOG4107TY6 Acylneuraminate cytidylyltransferase BS467_05950 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG BS467_05955 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BS467_05960 ENOG4105C1B dTDP-glucose 4-6-dehydratase BS467_05965 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BS467_05970 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase BS467_05980 ENOG4105CHM Aminotransferase BS467_05985 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase BS467_05990 ENOG4105CHR reductase BS467_05995 ENOG4106CHD Bacilysin biosynthesis protein bacB BS467_06000 ENOG41061WN bacilysin biosynthesis protein BS467_06005 ENOG4105FCW Major Facilitator superfamily BS467_06015 ENOG4105F27 Major Facilitator BS467_06020 ENOG4107JTW chlorite dismutase BS467_06025 ENOG4108IJ2 phosphate acetyltransferase BS467_06035 ENOG4105JSC dimethylmenaquinone methyltransferase BS467_06065 ENOG4107EV6 Inherit from COG: YD repeat protein BS467_06090 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BS467_06100 ENOG4107QZ7 Cellulose synthase catalytic subunit BS467_06110 ENOG4108VCI transcription factor, rsfa family BS467_06115 ENOG4105QAT UPF0741 protein BS467_06120 ENOG4105DCI Phosphohydrolase BS467_06130 ENOG4105CDA abc transporter atp-binding protein BS467_06135 ENOG4105E5Q amino acid AbC transporter BS467_06150 ENOG4108XSB acetyltransferase, (GNAT) family BS467_06160 ENOG4105DEN Luciferase family BS467_06165 ENOG4108UZX fmn reductase BS467_06170 ENOG4108KSA LysR family transcriptional regulator BS467_06185 ENOG41069HH 4-oxalocrotonate tautomerase BS467_06190 ENOG4108Z4T Peptidase M50 BS467_06195 ENOG4108XFG YwhD family BS467_06200 ENOG4105BZ4 penicillin-binding protein BS467_06205 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BS467_06210 ENOG4105CYW agmatinase BS467_06220 ENOG410684U Domain of unknown function (DUF1934) BS467_06225 ENOG4105C75 arginyL-tRNA synthetase BS467_06235 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BS467_06240 ENOG4105BZ1 (ABC) transporter BS467_06250 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BS467_06270 ENOG4105DF6 Fe-S oxidoreductase BS467_06280 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BS467_06285 ENOG4105C1G acyl-Coa dehydrogenase BS467_06290 ENOG4105C1G acyl-Coa dehydrogenase BS467_06300 ENOG41081I9 integral membrane protein BS467_06310 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BS467_06320 ENOG410812K response regulator receiver protein BS467_06325 ENOG4105D2N Aldolase BS467_06335 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BS467_06340 ENOG4105CBT Fructose-1,6-bisphosphatase BS467_06345 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BS467_06350 ENOG41082DI 50s ribosomal protein l31 BS467_06355 ENOG4107104 thymidine kinase BS467_06360 ENOG4105C6K Malic enzyme BS467_06365 ENOG4107TT2 Auxin Efflux Carrier BS467_06375 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BS467_06380 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BS467_06390 ENOG4108ZXQ stage ii sporulation protein r BS467_06400 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BS467_06410 ENOG4107WAU Protein tyrosine phosphatase BS467_06415 ENOG4108YZG isomerase BS467_06420 ENOG4108UIC UPF0340 protein BS467_06425 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BS467_06430 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BS467_06440 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BS467_06460 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BS467_06465 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BS467_06470 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BS467_06475 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BS467_06485 ENOG4106778 Protein of unknown function (DUF1146) BS467_06495 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BS467_06510 ENOG4108TF4 von Willebrand factor, type A BS467_06515 ENOG4108J2R molybdopterin oxidoreductase BS467_06520 ENOG4105FCD Major Facilitator BS467_06525 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BS467_06535 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BS467_06540 ENOG4105CKI cobalamin synthesis protein BS467_06545 ENOG4105WDJ 50S ribosomal protein L33 BS467_06585 ENOG4107TCE N-acetyltransferase BS467_06590 ENOG4105FRN stage II sporulation protein BS467_06600 ENOG4105BZU Histidine kinase BS467_06605 ENOG4105CDA abc transporter atp-binding protein BS467_06610 ENOG4105E5Q amino acid AbC transporter BS467_06615 ENOG4105EAB amino acid AbC transporter BS467_06620 ENOG41080V3 Major Facilitator superfamily BS467_06625 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BS467_06630 ENOG4105CZM Major Facilitator BS467_06635 ENOG4107MII Sugar-specific transcriptional regulator TrmB BS467_06640 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BS467_06645 ENOG4105DFF Rod shape-determining protein mreb BS467_06655 ENOG4105CGA flagellar basal-body rod protein FlgG BS467_06665 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BS467_06670 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BS467_06685 ENOG410667J hydrolase BS467_06690 ENOG4105BZU Histidine kinase BS467_06695 ENOG4105C0D helicase BS467_06700 ENOG4105KBK Zinc finger, swim domain protein BS467_06705 ENOG4105C6Y Udp-glucose 6-dehydrogenase BS467_06710 ENOG4105FGV Chromate BS467_06715 ENOG4105CAH Chromate BS467_06725 ENOG4107FQX Alpha-acetolactate decarboxylase BS467_06735 ENOG4107RSM transcriptional regulator BS467_06740 ENOG4107XC4 flavin reductase domain protein, FMN-binding BS467_06745 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BS467_06750 ENOG4105CNN ABC, transporter BS467_06755 ENOG4105C2J ABC transporter BS467_06760 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BS467_06765 ENOG4108RVA ribokinase BS467_06770 ENOG4105ETE Transcriptional regulator (LacI family BS467_06790 ENOG4105N98 Capsule biosynthesis protein capB BS467_06800 ENOG4105PNM synthesis protein BS467_06805 ENOG4105K4H Nlp p60 protein BS467_06810 ENOG4105J7I hydrolase BS467_06815 ENOG4108KGH TRANSCRIPTIONal BS467_06820 ENOG4105C54 Major Facilitator superfamily BS467_06825 ENOG4107RGC Glycosyl transferase, family 2 BS467_06835 ENOG4108NHD germination protein BS467_06850 ENOG4105CHR reductase BS467_06855 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) BS467_06860 ENOG4108M60 Transcriptional regulator BS467_06865 ENOG4105D7K pfkb domain protein BS467_06870 ENOG4108UHU Aldolase BS467_06875 ENOG4105I4A GCN5-related N-acetyltransferase BS467_06885 ENOG4105C2F Histidine kinase BS467_06890 ENOG4105WH1 Two component transcriptional regulator luxr family BS467_06895 ENOG4108JP0 extracellular solute-binding protein family 1 BS467_06900 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BS467_06910 ENOG4105DG6 mannose-6-phosphate isomerase BS467_06920 ENOG4107RZX Teichoic acid biosynthesis protein BS467_06930 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BS467_06940 ENOG4107SJB teichoic acid biosynthesis BS467_06955 ENOG4105EY8 ABC transporter BS467_06960 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BS467_06965 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BS467_06975 ENOG4108KGH TRANSCRIPTIONal BS467_06985 ENOG4105JFG SpoIID LytB domain protein BS467_06990 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BS467_06995 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BS467_07005 ENOG4105D3Q Sugar transferase BS467_07010 ENOG4105PSV Polysaccharide Biosynthesis Protein BS467_07015 ENOG4107RA4 Glycosyl transferase (Group 1 BS467_07020 ENOG4105C6Y Udp-glucose 6-dehydrogenase BS467_07025 ENOG4105C1B dTDP-glucose 4-6-dehydratase BS467_07030 ENOG4105QZI O-Antigen Polymerase BS467_07045 ENOG4107EF8 Glycosyl transferase (Group 1 BS467_07050 ENOG4105ESV Glycosyl transferase, family 4 BS467_07055 ENOG4108KGH TRANSCRIPTIONal BS467_07060 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BS467_07065 ENOG4105BZU Histidine kinase BS467_07070 ENOG4105WH1 Two component transcriptional regulator luxr family BS467_07090 ENOG41081UC Inherit from COG: Competence protein BS467_07095 ENOG4105RU3 BS467_07110 ENOG4105E1Q flagellar hook-associated protein BS467_07115 ENOG4105DTJ flagellar hook-associated protein BS467_07120 ENOG4105MKD BS467_07125 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BS467_07130 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BS467_07135 ENOG41083S7 flagellar protein FlaG BS467_07140 ENOG4107RT6 flagellar hook-associated BS467_07145 ENOG4105MQ3 flagellar protein FliS BS467_07160 ENOG4105C8Q Methyl-accepting chemotaxis BS467_07165 ENOG4105MS2 ribosomal subunit Interface protein BS467_07175 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BS467_07200 ENOG4105CAK Cell division ATP-binding protein ftsE BS467_07205 ENOG4105CRP Part of the ABC transporter FtsEX involved in BS467_07220 ENOG4105CN1 protease BS467_07235 ENOG4105KVH Transcriptional regulator BS467_07240 ENOG4108RCM Nitroreductase BS467_07250 ENOG4105CKK Glycosyl transferase, family 2 BS467_07255 ENOG4105EDW glycosyl transferase, family 39 BS467_07260 ENOG4105BZU Histidine kinase BS467_07265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS467_07280 ENOG4105MKU Transcriptional regulator BS467_07295 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BS467_07300 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BS467_07315 ENOG4108PY7 BS467_07320 ENOG41067S9 phage shock protein C, PspC BS467_07325 ENOG41086DT Membrane protein of unknown function BS467_07330 ENOG41088CQ domain protein BS467_07335 ENOG4105FDP GntR family transcriptional regulator BS467_07340 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BS467_07345 ENOG4105CE4 GlcNAc 6-P deacetylase BS467_07350 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BS467_07355 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BS467_07360 ENOG4105HKU nucleoside recognition domain-containing protein BS467_07365 ENOG4107XGZ Hydrolase BS467_07370 ENOG4108S4C acetyltransferase BS467_07375 ENOG4108Z40 Transcriptional regulator BS467_07380 ENOG4108RYK Nad-dependent epimerase dehydratase BS467_07395 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BS467_07400 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BS467_07405 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BS467_07410 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BS467_07415 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BS467_07420 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BS467_07425 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BS467_07430 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BS467_07445 ENOG4105C3M thioredoxin reductase BS467_07450 ENOG4108Z4K mutator MutT protein BS467_07455 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BS467_07460 ENOG4105CHW UPF0052 protein BS467_07465 ENOG4105CIE May be required for sporulation (By similarity) BS467_07470 ENOG4105KRI phosphocarrier protein (HPr BS467_07475 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BS467_07485 ENOG4105C5I Dehydrogenase BS467_07490 ENOG4108V2W Carbonate dehydratase BS467_07495 ENOG4105CHH sulfate transporter BS467_07505 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BS467_07510 ENOG4108URH decarboxylase BS467_07515 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BS467_07645 ENOG4105C2M dna polymerase I BS467_07660 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BS467_07680 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BS467_07685 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BS467_07705 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BS467_07720 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BS467_07730 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BS467_07895 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BS467_07930 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BS467_07965 ENOG4108MES Periplasmic binding protein BS467_07980 ENOG4108ZJ4 polysaccharide deacetylase BS467_07990 ENOG4105EHG Permease protein BS467_07995 ENOG4108V5C ABC transporter BS467_08010 ENOG4105HTX biosynthesis protein BS467_08015 ENOG4108QV3 biosynthesis protein BS467_08025 ENOG4108PQP glycosyl transferase group 1 BS467_08030 ENOG4105K64 Glycosyl transferase, family 2 BS467_08035 ENOG4108KMV Glycosyl transferase (Group 1 BS467_08040 ENOG41068W6 Capsular polysaccharide biosynthesis protein BS467_08045 ENOG4107QRS glycosyltransferase group 2 family protein BS467_08060 ENOG4105D3Q Sugar transferase BS467_08065 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family BS467_08070 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BS467_08075 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BS467_08080 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BS467_08085 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BS467_08090 ENOG4105C3U ABC transporter BS467_08095 ENOG4108JQ7 (ABC) transporter BS467_08100 ENOG4107R73 Mate efflux family protein BS467_08110 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS467_08115 ENOG4105JXH GntR family transcriptional regulator BS467_08125 ENOG4108JUB Transcriptional regulator BS467_08130 ENOG4105C8Y Acetylornithine aminotransferase BS467_08145 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BS467_08150 ENOG4105BZA Phosphoglycerate kinase BS467_08155 ENOG4105CP7 Triose-phosphate isomerase BS467_08165 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BS467_08195 ENOG4108W0I acetyltransferase BS467_08205 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BS467_08210 ENOG4107HG4 Transcriptional regulator BS467_08215 ENOG4108IJ8 ABC transporter BS467_08220 ENOG4105E90 ABC transporter BS467_08225 ENOG4108HQR Glycine betaine BS467_08230 ENOG4105R40 Glycine betaine carnitine choline BS467_08235 ENOG4105KVH Transcriptional regulator BS467_08260 ENOG4105XZU Preprotein translocase, subunit SecG BS467_08270 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BS467_08275 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BS467_08300 ENOG4105BZU Histidine kinase BS467_08310 ENOG4105VPX protein, conserved in bacteria BS467_08315 ENOG410681U heavy metal transport detoxification protein BS467_08320 ENOG4105C59 p-type ATPase BS467_08335 ENOG4108IJ0 Aspartate ammonia-lyase BS467_08350 ENOG4105W1N transcriptional regulator BS467_08355 ENOG4105IIP Membrane BS467_08360 ENOG4105DSE periplasmic solute binding protein BS467_08365 ENOG4105CC5 ABC transporter BS467_08370 ENOG4105DIK (ABC) transporter BS467_08375 ENOG4105C59 p-type ATPase BS467_08380 ENOG4107ZQN disulfide bond BS467_08395 ENOG4105EN6 Membrane BS467_08400 ENOG4107SUZ Sodium/hydrogen exchanger family BS467_08405 ENOG4105EVU fructokinase BS467_08415 ENOG4105E0C molybdate abc transporter BS467_08420 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BS467_08425 ENOG4107QZ2 Sulfatase BS467_08430 ENOG4107K5X Membrane-bound metal-dependent hydrolase BS467_08450 ENOG4105D5Q Arginine ornithine antiporter BS467_08460 ENOG4105DQ5 transport system permease protein BS467_08465 ENOG4105EHG Permease protein BS467_08470 ENOG4105E0A ABC, transporter BS467_08475 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BS467_08485 ENOG4105D2H Uronic isomerase BS467_08490 ENOG4107KJX Transcriptional regulator BS467_08495 ENOG4107QZW Altronate oxidoreductase BS467_08500 ENOG4105CTX dehydratase BS467_08510 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BS467_08515 ENOG4105EHG Permease protein BS467_08520 ENOG4105E0A ABC, transporter BS467_08525 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BS467_08530 ENOG4105C0A alcohol dehydrogenase BS467_08545 ENOG4108JUA Transcriptional regulator BS467_08550 ENOG4107S2N Type III effector Hrp-dependent BS467_08555 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BS467_08565 ENOG4105CHR reductase BS467_08570 ENOG4108WBT adenosyltransferase BS467_08580 ENOG41087YS Phage shock protein A BS467_08595 ENOG4105ENE Histidine kinase BS467_08600 ENOG4105WH1 Two component transcriptional regulator luxr family BS467_08630 ENOG4105C9Q fumarate hydratase class II BS467_08635 ENOG41067SE Tetr family transcriptional regulator BS467_08640 ENOG4105F3H Histidine kinase BS467_08650 ENOG4105C0H protease BS467_08660 ENOG4105E1F short-chain dehydrogenase reductase BS467_08670 ENOG4105E0A ABC, transporter BS467_08705 ENOG4105CHU acetyl-coa acetyltransferase BS467_08710 ENOG4105C1G acyl-Coa dehydrogenase BS467_08715 ENOG41080E8 Transcriptional regulator, Spx MgsR family BS467_08720 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BS467_08745 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BS467_08750 ENOG4108UMI ABC transporter, permease BS467_08755 ENOG4105D01 (LipO)protein BS467_08770 ENOG4105C3K feS assembly ATPase SufC BS467_08775 ENOG4105JRK feS assembly protein SufD BS467_08780 ENOG4105C9B Cysteine desulfurase BS467_08785 ENOG4108UNV SUF system FeS assembly protein, NifU family BS467_08790 ENOG4105DIW FeS assembly protein SUFB BS467_08805 ENOG4108IG5 Transcriptional regulator BS467_08820 ENOG4105DZR Type I site-specific deoxyribonuclease BS467_08835 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BS467_08845 ENOG4105DHF Membrane BS467_08850 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BS467_08855 ENOG4108SWU Histidine kinase BS467_08880 ENOG4108MES Periplasmic binding protein BS467_08885 ENOG4105DQ5 transport system permease protein BS467_08890 ENOG4108IHU transport system permease protein BS467_08900 ENOG4108K8S endonuclease I BS467_08905 ENOG4105C5R Aminotransferase BS467_08915 ENOG4105F0F Oxalate decarboxylase BS467_08920 ENOG4105G9B Transcriptional regulator BS467_08925 ENOG4105I3N Conserved Protein BS467_08930 ENOG4107R8B 5'-nucleotidase BS467_08935 ENOG4105KZD Domain of unknown function (DUF1805) BS467_08940 ENOG4108YTE sporulation protein YunB BS467_08955 ENOG4105FAA peptidase M23 BS467_08965 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BS467_08970 ENOG4105MMD transcriptional regulator BS467_08980 ENOG4105D4U had-superfamily hydrolase, subfamily iia BS467_08985 ENOG4108W5N phosphatidylglycerophosphatase a BS467_08995 ENOG4105C5I Dehydrogenase BS467_09000 ENOG4105D6E homoserine dehydrogenase BS467_09005 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BS467_09015 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BS467_09020 ENOG41083MR nifu domain-containing protein BS467_09040 ENOG4105ZKE UPF0349 protein BS467_09045 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BS467_09050 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BS467_09075 ENOG4105CAY ferredoxin--nadp reductase BS467_09080 ENOG4105CEP NADH dehydrogenase BS467_09090 ENOG41069ER domain protein BS467_09100 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BS467_09115 ENOG4105DCF alanine dehydrogenase BS467_09120 ENOG4108K8K Transcriptional regulator BS467_09155 ENOG410904N short-chain dehydrogenase reductase BS467_09175 ENOG4105C02 permease BS467_09205 ENOG4105DAP Nicotinate phosphoribosyltransferase BS467_09210 ENOG4105D58 Diguanylate phosphodiesterase BS467_09235 ENOG4105BZU Histidine kinase BS467_09245 ENOG4105KA0 thioesterase Superfamily protein BS467_09250 ENOG4105KJM monovalent cation h antiporter subunit g BS467_09260 ENOG4105SC1 monovalent cation H antiporter subunit E BS467_09265 ENOG4108JPZ Monovalent cation H antiporter subunit D BS467_09270 ENOG4108ZE9 Monovalent cation H antiporter subunit C BS467_09275 ENOG4105HC0 Na H antiporter BS467_09280 ENOG4105D65 subunit l BS467_09300 ENOG4105UIB (ABC) transporter BS467_09305 ENOG4108JQ9 ABC transporter BS467_09310 ENOG4105DIH basic membrane BS467_09315 ENOG4108MRH transcriptional regulatory protein BS467_09330 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BS467_09335 ENOG4105BZ4 penicillin-binding protein BS467_09350 ENOG4105Y38 Kinase-associated protein B BS467_09355 ENOG4108HGU Histidine kinase BS467_09360 ENOG4105C87 Aminotransferase class I and II BS467_09370 ENOG4108MUZ hydrolase BS467_09375 ENOG4108ZB6 transcriptional regulator AsnC family BS467_09380 ENOG4105CHM Aminotransferase BS467_09390 ENOG4105WG9 Conserved Protein BS467_09395 ENOG4107QW4 alcohol dehydrogenase BS467_09405 ENOG4107QYV phosphohexose isomerase BS467_09420 ENOG4107PBV potassium channel BS467_09435 ENOG4105C37 (CBS) domain BS467_09440 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BS467_09445 ENOG4105EA8 2-Nitropropane dioxygenase BS467_09460 ENOG4105C8Q Methyl-accepting chemotaxis BS467_09465 ENOG4105C8Q Methyl-accepting chemotaxis BS467_09470 ENOG4105C8Q Methyl-accepting chemotaxis BS467_09475 ENOG4105C8Q Methyl-accepting chemotaxis BS467_09480 ENOG4108Z0Z intracellular protease Pfpi family BS467_09485 ENOG4105EE0 oxidoreductase BS467_09500 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BS467_09510 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BS467_09535 ENOG4105QBX endodeoxyribonuclease RusA BS467_09555 ENOG4105IG6 Phage terminase, large subunit BS467_09560 ENOG4108MDF Phage Portal Protein BS467_09585 ENOG41060SN BS467_09600 ENOG4105PQS phage protein BS467_09605 ENOG4105FR7 XkdM protein, phage-like element PBSX BS467_09615 ENOG4105MTC XkdN-like protein BS467_09620 ENOG4108FKH Transglycosylase SLT domain BS467_09620 ENOG4108FKH Transglycosylase SLT domain BS467_09625 ENOG4108WZM domain protein BS467_09630 ENOG4105X7F BS467_09640 ENOG4105MFU Protein of unknown function (DUF2634) BS467_09645 ENOG41066EA baseplate J family protein BS467_09650 ENOG410906S phage-like element pbsx protein xkdt BS467_09680 ENOG41068G1 BS467_09705 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BS467_09720 ENOG4105TRT Transcriptional regulator BS467_09725 ENOG4105C26 Dehydrogenase BS467_09730 ENOG4108JB8 alcohol dehydrogenase BS467_09735 ENOG4106DF1 BS467_09745 ENOG4105DZ6 Band 7 protein BS467_09750 ENOG4105CNI cell division protein FtsW BS467_09755 ENOG4105CNI cell division protein FtsW BS467_09765 ENOG4105VRR gCN5-related N-acetyltransferase BS467_09775 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BS467_09900 ENOG4108606 TspO/MBR family BS467_09910 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BS467_09915 ENOG4105E4F Isochorismate synthase BS467_09920 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BS467_09925 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BS467_09930 ENOG4108IPT Naphthoate synthase BS467_09940 ENOG4105DTQ mandelate racemase muconate lactonizing BS467_09970 ENOG4105NRA 50s ribosomal protein l31 type b BS467_09975 ENOG4105DSE periplasmic solute binding protein BS467_09980 ENOG4108V2W Carbonate dehydratase BS467_09985 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BS467_09990 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BS467_10005 ENOG4108RMU ferritin dps family protein BS467_10030 ENOG4106FN3 tellurium resistance protein BS467_10040 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BS467_10050 ENOG4105D2X ABC transporter substrate-binding protein BS467_10070 ENOG4105EWK phytoene BS467_10090 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BS467_10095 ENOG4105CAQ asparagine synthetase BS467_10100 ENOG4108Z0R Transferase BS467_10105 ENOG4105E8V Alpha Beta Hydrolase Fold protein BS467_10115 ENOG4108N23 SpoOM-related protein BS467_10125 ENOG4105N5T Radical SAM Protein BS467_10145 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BS467_10150 ENOG4105DVE abc transporter atp-binding protein BS467_10160 ENOG4105C19 ABC transporter BS467_10165 ENOG4107R34 abc transporter permease protein BS467_10170 ENOG4106UBQ BS467_10175 ENOG4105BZU Histidine kinase BS467_10185 ENOG4105C8T Leucyl-tRNA synthetase BS467_10190 ENOG4105NTD Inherit from COG: Hydrolase BS467_10200 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component BS467_10210 ENOG4105CV8 reductase BS467_10215 ENOG4105F27 Major Facilitator BS467_10220 ENOG4105KVH Transcriptional regulator BS467_10225 ENOG41075H3 AraC family transcriptional regulator BS467_10235 ENOG4105F5H Glycosyl Hydrolase Family 88 BS467_10245 ENOG4105DDC Oxidoreductase domain protein BS467_10250 ENOG4105MU9 integral membrane protein BS467_10255 ENOG41085GJ domain protein BS467_10265 ENOG4106611 bacteriocin immunity BS467_10270 ENOG4105C94 Transporter BS467_10280 ENOG4105CBX hi0933 family BS467_10295 ENOG4105YW5 deoR family transcriptional regulator BS467_10300 ENOG4105C7N Xanthine uracil vitamin C permease BS467_10305 ENOG4107QSE Dipeptidase BS467_10310 ENOG4107UIE peptidase BS467_10315 ENOG4105C6T cysteine synthase BS467_10320 ENOG4107F58 2'-5' rna ligase BS467_10335 ENOG4108V15 phosphotransferase enzyme family BS467_10345 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BS467_10350 ENOG4105C8F Beta-lactamase domain protein BS467_10355 ENOG4105C6K Malic enzyme BS467_10370 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BS467_10385 ENOG4108NKM UPF0354 protein BS467_10390 ENOG4108VDD TRNA binding domain protein BS467_10400 ENOG4105DFU Cell wall formation (By similarity) BS467_10420 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BS467_10425 ENOG4105ETE Transcriptional regulator (LacI family BS467_10430 ENOG4105DGU Histone deacetylase BS467_10435 ENOG4105W87 Cbs domain BS467_10440 ENOG4105F1V Acetoin utilization protein BS467_10450 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BS467_10455 ENOG4105KAC Antibiotic biosynthesis monooxygenase BS467_10460 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BS467_10480 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BS467_10490 ENOG4105U5Y Transcriptional regulator BS467_10520 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BS467_10530 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BS467_10535 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BS467_10550 ENOG4108X0B nad(p)h dehydrogenase (quinone) BS467_10555 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BS467_10565 ENOG4105C19 ABC transporter BS467_10570 ENOG4105EWM Histidine kinase BS467_10575 ENOG4105CJZ response regulator BS467_10585 ENOG4108S01 response regulator BS467_10590 ENOG4108ZGX Histidine kinase BS467_10595 ENOG4105ECK Fatty Acid Desaturase BS467_10600 ENOG4105C1J atp-dependent rna helicase BS467_10605 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BS467_10610 ENOG4105D07 Signal peptide peptidase, SppA BS467_10615 ENOG4105VK3 rdd domain containing protein BS467_10625 ENOG4105KBJ sporulation protein ytfj BS467_10630 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BS467_10640 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BS467_10645 ENOG4105EPU Molybdenum cofactor synthesis domain protein BS467_10650 ENOG4105CDH Citrulline--aspartate ligase BS467_10655 ENOG4105CH7 arginosuccinase BS467_10670 ENOG4105E8R UPF0173 metal-dependent hydrolase BS467_10690 ENOG4105SFS phosphoesterase RecJ domain protein BS467_10695 ENOG4106EVM BS467_10705 ENOG4105VV2 BS467_10710 ENOG4105C0B DNA polymerase III (alpha subunit) BS467_10715 ENOG4105C6K Malic enzyme BS467_10720 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BS467_10730 ENOG4105CTQ phosphohexokinase BS467_10735 ENOG4105CA9 Pyruvate kinase BS467_10740 ENOG4105FS0 cytoplasmic membrane protein BS467_10745 ENOG4108REF Sporulation integral membrane protein ytvi BS467_10750 ENOG4107CWS Protein of unknown function (DUF441) BS467_10755 ENOG4105BZN citrate synthase BS467_10760 ENOG4108HMX isocitrate dehydrogenase (NADP) BS467_10765 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BS467_10770 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BS467_10775 ENOG4105BZU Histidine kinase BS467_10780 ENOG4105C2M dna polymerase I BS467_10785 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BS467_10795 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BS467_10800 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BS467_10805 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BS467_10815 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BS467_10835 ENOG4108TDW sporulation protein YtxC BS467_10840 ENOG4105C22 threonyL-tRNA synthetase BS467_10845 ENOG4107SDU Methyl-accepting chemotaxis BS467_10850 ENOG4105U0R haloacid dehalogenase-like hydrolase BS467_10865 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BS467_10870 ENOG4105VJV 50s ribosomal protein L35 BS467_10875 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BS467_10880 ENOG410696E Membrane BS467_10890 ENOG4105CN9 Peptidase m42 family protein BS467_10900 ENOG41067MF small acid-soluble spore protein BS467_10905 ENOG4108RWN rrna methyltransferase BS467_10910 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BS467_10915 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BS467_10920 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BS467_10925 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BS467_10935 ENOG4105DCG PHP domain protein BS467_10940 ENOG4105C98 muts2 protein BS467_10955 ENOG4105CEY Amp-dependent synthetase and ligase BS467_10960 ENOG4107Z3H Transcriptional regulator, TetR family BS467_10965 ENOG41060WC Enoyl-CoA hydratase BS467_10970 ENOG4105BZJ Electron transfer flavoprotein BS467_10975 ENOG4105C10 Electron transfer flavoprotein BS467_10980 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BS467_10985 ENOG4105K63 Thioredoxin BS467_10990 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BS467_10995 ENOG4105CFH Aspartokinase BS467_11005 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BS467_11015 ENOG4105E33 succinate dehydrogenase BS467_11025 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BS467_11030 ENOG4105C7F AcnD-accessory protein PrpF BS467_11035 ENOG4108KAM Transcriptional regulator BS467_11045 ENOG4105PFC Transcriptional regulator BS467_11050 ENOG41067TZ transcriptional regulator, MarR family BS467_11055 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BS467_11060 ENOG4108XJQ germination protein BS467_11065 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BS467_11070 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BS467_11075 ENOG4105M59 Phosphodiesterase, mj0936 family BS467_11110 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BS467_11115 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BS467_11125 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BS467_11140 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BS467_11145 ENOG4105CM2 brancheD-chain amino acid aminotransferase BS467_11150 ENOG4105C7K acetolactate synthase BS467_11155 ENOG4108ZP8 Acetolactate synthase small subunit BS467_11160 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BS467_11165 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BS467_11170 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BS467_11175 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BS467_11180 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BS467_11190 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BS467_11195 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BS467_11200 ENOG4108IUQ atp-dependent protease BS467_11205 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BS467_11210 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BS467_11220 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BS467_11230 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BS467_11240 ENOG4105D52 delta-aminolevulinic acid dehydratase BS467_11245 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BS467_11255 ENOG41068KH stage VI sporulation protein D BS467_11260 ENOG4106AR7 Spore coat protein BS467_11270 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BS467_11275 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BS467_11280 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) BS467_11290 ENOG4108Z03 MAF-like protein BS467_11295 ENOG4105W5Q DNA repair protein (RadC BS467_11300 ENOG4105DFF Rod shape-determining protein mreb BS467_11305 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BS467_11310 ENOG4105YHC Rod shape-determining protein MreD BS467_11315 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BS467_11320 ENOG4107QMS site-determining protein BS467_11335 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BS467_11340 ENOG4105X36 (ribosomal) protein BS467_11345 ENOG4105K46 50S ribosomal protein l27 BS467_11355 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BS467_11365 ENOG4105CQC Prephenate dehydratase BS467_11380 ENOG4108IYU L-aspartate oxidase BS467_11385 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BS467_11390 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BS467_11395 ENOG4106678 morphogenetic protein associated with SpoVID BS467_11410 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BS467_11435 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BS467_11440 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BS467_11445 ENOG41061AI Protein of unknown function (DUF2905) BS467_11450 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BS467_11455 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BS467_11460 ENOG4105VIE preprotein translocase, subunit YajC BS467_11465 ENOG4105NAP BS467_11470 ENOG4108QG2 Membrane BS467_11475 ENOG4105CKP Polysaccharide Biosynthesis Protein BS467_11485 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BS467_11490 ENOG4105NCW Trka-c domain protein BS467_11495 ENOG41067VP Protein of unknown function (DUF1049) BS467_11500 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BS467_11505 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BS467_11510 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BS467_11515 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BS467_11520 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BS467_11525 ENOG4105CUT histidyl-tRNA synthetase BS467_11530 ENOG4105C9M aspartyl-trna synthetase BS467_11540 ENOG4105CUZ uba thif-type nad fad binding protein BS467_11545 ENOG4105D1H recombination factor protein RarA BS467_11555 ENOG4105C3J Cysteine desulfurase BS467_11560 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BS467_11570 ENOG4105C7H Helicase, RecD TraA family BS467_11585 ENOG41060CR BS467_11595 ENOG4105DRP amino acid AbC transporter BS467_11600 ENOG4105EAD ABC transporter BS467_11605 ENOG4105CT1 (ABC) transporter BS467_11610 ENOG4105CDA abc transporter atp-binding protein BS467_11615 ENOG4105C02 permease BS467_11625 ENOG4105VBH UPF0297 protein BS467_11630 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BS467_11635 ENOG4105VPH UPF0473 protein BS467_11640 ENOG4107ZYJ bioY protein BS467_11645 ENOG4107F3J Amp-dependent synthetase and ligase BS467_11655 ENOG4105HHA aminodeoxychorismate lyase BS467_11660 ENOG4108VQJ O-methyltransferase BS467_11665 ENOG4105XYU peptidase (U32 family) BS467_11670 ENOG4105CFP Peptidase U32 BS467_11675 ENOG4107S03 uridine kinase BS467_11680 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BS467_11685 ENOG4107XRG penicillin-binding protein BS467_11700 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BS467_11705 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BS467_11715 ENOG4105C28 cystathionine BS467_11740 ENOG4105E2A Dehydrogenase BS467_11745 ENOG4105CJ1 ABC, transporter BS467_11750 ENOG41090VJ ABC-2 type transporter BS467_11755 ENOG4108KYE ABC-2 type transporter BS467_11760 ENOG4107V2S Transcriptional regulator BS467_11775 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BS467_11790 ENOG4105WEF catalase BS467_11795 ENOG4105E5Q amino acid AbC transporter BS467_11815 ENOG4105FDT acyl-CoA dehydrogenase BS467_11820 ENOG4108HWY Beta-lactamase BS467_11885 ENOG4105KVH Transcriptional regulator BS467_11890 ENOG4108VA3 3-hexulose-6-phosphate synthase BS467_11895 ENOG41080HJ 6-phospho 3-hexuloisomerase BS467_11905 ENOG4105NTK Transcriptional repressor Mpra BS467_11915 ENOG4105CMD Transcriptional regulator, GntR family BS467_11930 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) BS467_11935 ENOG4107QNK )-transporter BS467_11960 ENOG4105CJ1 ABC, transporter BS467_11995 ENOG4108ZJ4 polysaccharide deacetylase BS467_12025 ENOG4108IUS Transketolase BS467_12030 ENOG4105CHR reductase BS467_12040 ENOG4107YCY Transcriptional regulator BS467_12050 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS467_12075 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BS467_12080 ENOG4105CQW ribosome biogenesis GTPase YqeH BS467_12085 ENOG4105E2X shikimate dehydrogenase BS467_12090 ENOG410812S Rna-binding protein BS467_12095 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BS467_12100 ENOG4108WF2 Metal Dependent Phosphohydrolase BS467_12110 ENOG4108D32 Methyltransferase BS467_12120 ENOG4105KQC Competence protein BS467_12125 ENOG4108UK2 deaminase BS467_12130 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BS467_12140 ENOG4105TQK DNA polymerase iii, delta' subunit BS467_12155 ENOG4108ZRV stage ii sporulation protein p BS467_12165 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BS467_12170 ENOG4105CSA Coproporphyrinogen iii oxidase BS467_12175 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BS467_12180 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BS467_12190 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BS467_12195 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BS467_12200 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BS467_12205 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BS467_12220 ENOG4105KTH gatB Yqey BS467_12225 ENOG4105F7J membrane-bound serine protease BS467_12230 ENOG4105DI5 UPF0365 protein BS467_12240 ENOG41068P3 sporulation protein YqfC BS467_12245 ENOG4105EI1 sporulation protein yqfd BS467_12250 ENOG4105C9A Phoh family BS467_12255 ENOG4105CTJ Metal Dependent Phosphohydrolase BS467_12260 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BS467_12265 ENOG4107YR5 Diacylglycerol kinase BS467_12270 ENOG4105KG3 cytidine deaminase BS467_12275 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BS467_12285 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) BS467_12290 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BS467_12295 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BS467_12305 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BS467_12310 ENOG4108UPT UPF0178 protein BS467_12315 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BS467_12320 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS467_12335 ENOG4105EGD dinuclear metal center protein, YbgI family BS467_12340 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BS467_12355 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BS467_12360 ENOG41069ZM Protein of unknown function (DUF2624) BS467_12365 ENOG4108JYZ YitT family BS467_12370 ENOG4105FDK ABC transporter BS467_12375 ENOG4105FAV ABC, transporter BS467_12380 ENOG4105N80 Ferric uptake regulator, Fur family BS467_12385 ENOG41066F8 ROK family BS467_12390 ENOG4108U5J '-nucleotidase BS467_12395 ENOG41063Y9 BS467_12400 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BS467_12410 ENOG4105D9U N-acetyltransferase BS467_12420 ENOG4105SXS Protein of unknown function (DUF456) BS467_12425 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BS467_12435 ENOG4107RF6 penicillin-binding protein BS467_12440 ENOG4105CVA phosphate BS467_12445 ENOG4105C8U phosphate abc transporter BS467_12450 ENOG4105E2Z phosphate ABC transporter (Permease BS467_12455 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BS467_12460 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BS467_12465 ENOG41068DG YceG-like family BS467_12480 ENOG4105WDJ 50S ribosomal protein L33 BS467_12485 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BS467_12495 ENOG4107ZXI Rhomboid family BS467_12510 ENOG4105E0M Sulfatase BS467_12540 ENOG4105C5X domain protein BS467_12575 ENOG4106855 Competence protein BS467_12615 ENOG4105VFR signal peptidase BS467_12640 ENOG4105C0D helicase BS467_12645 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BS467_12655 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BS467_12660 ENOG4105WZW rhodanese family BS467_12665 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BS467_12670 ENOG4105KST dependent repressor BS467_12690 ENOG4105CBJ Metal-dependent enzyme BS467_12700 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BS467_12705 ENOG4105DC7 peptidase M24 BS467_12710 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BS467_12720 ENOG4105CD2 stage iii sporulation protein aa BS467_12725 ENOG4105KR5 Stage iii sporulation protein BS467_12730 ENOG4108CQH stage III sporulation protein AC BS467_12735 ENOG4105KQ4 Stage iii sporulation protein ad BS467_12745 ENOG410644B Stage III sporulation protein af BS467_12765 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BS467_12770 ENOG4108ZSR alkaline shock protein BS467_12780 ENOG4105M7K Involved in the transcription termination process (By similarity) BS467_12785 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BS467_12790 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BS467_12795 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BS467_12800 ENOG4105CTB Polyprenyl synthetase BS467_12805 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BS467_12810 ENOG4105DX0 Hemolysin A BS467_12815 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BS467_12820 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BS467_12825 ENOG4105S1Z Stage IV sporulation protein B BS467_12830 ENOG4107QQR Sporulation BS467_12840 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BS467_12845 ENOG4106CCJ Protein of unknown function (DUF2627) BS467_12850 ENOG4108JUB Transcriptional regulator BS467_12860 ENOG4107RDP Dehydrogenase BS467_12865 ENOG4105CKM Branched-chain carboxylic acid kinase BS467_12880 ENOG4105CPP Dehydrogenase, E1 component BS467_12885 ENOG4105C7S Dehydrogenase BS467_12895 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BS467_12900 ENOG4108Y6J UPF0403 protein BS467_12905 ENOG4108HW3 (ABC) transporter BS467_12910 ENOG4105E5Q amino acid AbC transporter BS467_12915 ENOG4105CDA abc transporter atp-binding protein BS467_12920 ENOG4108QEG Membrane BS467_12925 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BS467_12930 ENOG4108ZVT methylmalonyl-coA epimerase BS467_12935 ENOG4108HNZ carboxyl transferase BS467_12940 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BS467_12945 ENOG4108V3W Chemotaxis protein, CheW BS467_12950 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) BS467_12960 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BS467_12965 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BS467_12970 ENOG4105CSC Glucose uptake protein BS467_12975 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BS467_12985 ENOG4105VZJ PTS System BS467_12990 ENOG4105VCP PTS System BS467_12995 ENOG4105CK1 PTS System BS467_13000 ENOG4105CS2 ec 3.2.1.21 BS467_13005 ENOG4108TZY GntR Family Transcriptional Regulator BS467_13010 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BS467_13015 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BS467_13020 ENOG4105XT2 Transcriptional regulator BS467_13030 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BS467_13045 ENOG4105II7 pyrroline-5-carboxylate reductase BS467_13050 ENOG41069FQ Metallo-beta-lactamase superfamily BS467_13055 ENOG4108IXY short-chain dehydrogenase reductase BS467_13065 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BS467_13080 ENOG4105E5W Transporter BS467_13090 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BS467_13100 ENOG4108XET gCN5-related N-acetyltransferase BS467_13105 ENOG4105RHY Pfam:UPF0157 BS467_13110 ENOG4108YQE rare lipoprotein a BS467_13115 ENOG4106HZJ BS467_13140 ENOG4105CPC Aldo Keto reductase BS467_13145 ENOG4108YZ4 nudix hydrolase BS467_13155 ENOG4107YB6 acetyltransferase, (GNAT) family BS467_13175 ENOG4105MZ9 stage II sporulation protein m BS467_13180 ENOG4105I3K Ferric uptake regulator, Fur family BS467_13190 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BS467_13195 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BS467_13200 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) BS467_13205 ENOG4105DZ1 carboxypeptidase BS467_13210 ENOG41082AN stage II sporulation protein BS467_13215 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BS467_13220 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS467_13235 ENOG41090VF Stage v sporulation protein ac BS467_13240 ENOG4105CZ3 stage V sporulation protein ad BS467_13250 ENOG4105G6R Stage v sporulation protein ae BS467_13260 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BS467_13265 ENOG4105PTM secreted protein BS467_13270 ENOG4107ZE5 PPIases accelerate the folding of proteins BS467_13300 ENOG4108R6K riboflavin synthase, subunit alpha BS467_13310 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BS467_13335 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BS467_13340 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BS467_13350 ENOG4105DZ1 carboxypeptidase BS467_13355 ENOG4108JIC nucleoside recognition domain protein BS467_13365 ENOG4105FE9 pseudouridine synthase BS467_13375 ENOG4107TWT Cytochrome c biogenesis protein BS467_13380 ENOG4105CRE cytochrome C BS467_13385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS467_13390 ENOG4105BZU Histidine kinase BS467_13415 ENOG4108JQ1 Dehydrogenase BS467_13420 ENOG4108SAX Membrane BS467_13430 ENOG4105T7X BS467_13435 ENOG4105C9U ATP-dependent DNA helicase RecQ BS467_13440 ENOG4105I7S Abortive infection protein BS467_13455 ENOG4107RGJ metallophosphoesterase BS467_13470 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BS467_13475 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) BS467_13485 ENOG4105MSI germination protein ypeb BS467_13500 ENOG4105CAT Cytidine monophosphate kinase BS467_13505 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BS467_13530 ENOG4105S2F BS467_13535 ENOG41065D1 BS467_13540 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BS467_13545 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BS467_13560 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BS467_13570 ENOG4105K70 DNA-binding protein BS467_13575 ENOG4105EUJ GTP cyclohydrolase i BS467_13585 ENOG4105XXQ heptaprenyl diphosphate synthase component I BS467_13590 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BS467_13595 ENOG4105EAH synthase BS467_13600 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BS467_13605 ENOG4105BZU Histidine kinase BS467_13610 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BS467_13615 ENOG4105D49 3-dehydroquinate synthase BS467_13620 ENOG4105KHN chorismate mutase BS467_13630 ENOG4108I0Q anthranilate phosphoribosyltransferase BS467_13635 ENOG4105DK0 Indole-3-glycerol phosphate synthase BS467_13640 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BS467_13645 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BS467_13650 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BS467_13655 ENOG4105CIH Imidazole acetol-phosphate transaminase BS467_13665 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BS467_13670 ENOG41068YB TPR repeat-containing protein BS467_13675 ENOG4108SXZ UPF0302 protein BS467_13690 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BS467_13710 ENOG4108JYZ YitT family BS467_13715 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BS467_13720 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BS467_13725 ENOG4108Z5K methylglyoxal synthase BS467_13730 ENOG4105FJR Lmbe family BS467_13735 ENOG4105CPK Glycosyl transferase (Group 1 BS467_13740 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BS467_13750 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BS467_13755 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BS467_13760 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BS467_13765 ENOG4105DVT helicase BS467_13770 ENOG4105YAC BS467_13790 ENOG4105CSM endonuclease III BS467_13800 ENOG4105BZ4 penicillin-binding protein BS467_13805 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BS467_13845 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BS467_13850 ENOG4108I5C dEAD DEAH box helicase BS467_13855 ENOG4107X2U Inherit from COG: Exonuclease-like protein BS467_13865 ENOG4108UKS UPF0398 protein BS467_13870 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BS467_13880 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BS467_13890 ENOG4105DVT helicase BS467_13895 ENOG4105CTD carboxy-peptidase BS467_13905 ENOG4105C2W permease BS467_13910 ENOG4107VMI polysaccharide deacetylase BS467_13920 ENOG41065KQ synthase BS467_13930 ENOG410890F Dynamin family BS467_13950 ENOG41081VK Ribonuclease BS467_13985 ENOG4108QBV Monogalactosyldiacylglycerol synthase BS467_13990 ENOG4105CVG Homoserine O-transsuccinylase BS467_13995 ENOG4105CKU formyltetrahydrofolate synthetase BS467_14000 ENOG4108V06 Glutathione peroxidase BS467_14015 ENOG4105C01 Dihydroxy-acid dehydratase BS467_14020 ENOG4108Y6J UPF0403 protein BS467_14025 ENOG4107YX5 Pfam:DUF548 BS467_14040 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BS467_14045 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BS467_14055 ENOG4108UT2 hemolysin iii BS467_14065 ENOG4105C7B Threonine dehydratase BS467_14080 ENOG4108KF3 Electron transport protein SCO1 SenC BS467_14085 ENOG41090WU lipolytic protein G-D-S-L family BS467_14090 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) BS467_14120 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BS467_14125 ENOG4105E0X reductase BS467_14130 ENOG4105C5E polysaccharide biosynthesis protein BS467_14160 ENOG4108JUB Transcriptional regulator BS467_14165 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BS467_14175 ENOG4105VSD UPF0346 protein BS467_14190 ENOG410841Q phosphoesterase PA-phosphatase related protein BS467_14195 ENOG4106Z5R BS467_14200 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BS467_14205 ENOG4108VXD carboxy-peptidase BS467_14230 ENOG4105E1V na solute symporter BS467_14260 ENOG4105FR1 rard protein BS467_14280 ENOG4107QMU Mate efflux family protein BS467_14290 ENOG4105K4H Nlp p60 protein BS467_14300 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BS467_14305 ENOG4107T89 von Willebrand factor, type A BS467_14310 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BS467_14315 ENOG4105C7S Dehydrogenase BS467_14320 ENOG4105C09 Bile acid BS467_14325 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BS467_14330 ENOG4105EWU Squalene--hopene cyclase BS467_14335 ENOG4105C26 Dehydrogenase BS467_14365 ENOG4105SCY DNAK suppressor BS467_14375 ENOG4105C9U ATP-dependent DNA helicase RecQ BS467_14380 ENOG41069ER domain protein BS467_14390 ENOG4108SJC Membrane BS467_14400 ENOG4105DXD 2-methylcitrate dehydratase BS467_14405 ENOG4105CR4 methylisocitrate lyase BS467_14415 ENOG4105CUB amino acid BS467_14420 ENOG4105KTU Transcriptional regulator, arsr family BS467_14430 ENOG4105D29 Helix-turn-helix type 11 domain protein BS467_14440 ENOG4108W8B Beta-lactamase domain protein BS467_14460 ENOG4105FVX BS467_14470 ENOG4108Z7R Chaperone CsaA BS467_14475 ENOG4105CT4 transporter BS467_14485 ENOG4105E2R ROK family BS467_14495 ENOG4105CMG Carbohydrate kinase BS467_14505 ENOG4108J2R molybdopterin oxidoreductase BS467_14515 ENOG4105II7 pyrroline-5-carboxylate reductase BS467_14520 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BS467_14525 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BS467_14530 ENOG4108UYN gCN5-related N-acetyltransferase BS467_14535 ENOG41090E6 transcriptional regulator MERR family BS467_14540 ENOG4105BZ1 (ABC) transporter BS467_14550 ENOG4105C5Q Transcriptional regulator BS467_14555 ENOG4105CBC glutamate synthase BS467_14560 ENOG4105BZ8 glutamate synthase BS467_14575 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BS467_14580 ENOG4108IFG nitrite reductase, (NAD(P)H) BS467_14585 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BS467_14590 ENOG4105H67 Protein of unknown function (DUF421) BS467_14595 ENOG4105NBR Pectinesterase BS467_14600 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BS467_14605 ENOG4107QJQ Mate efflux family protein BS467_14620 ENOG4105DEN Luciferase family BS467_14630 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BS467_14635 ENOG4107T5V SNARE associated Golgi BS467_14640 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BS467_14660 ENOG4108B31 Spore germination protein BS467_14670 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BS467_14675 ENOG4105CQB FAD linked oxidase domain protein BS467_14690 ENOG41090U3 tautomerase BS467_14695 ENOG4105E98 transcriptional regulator DeoR family BS467_14705 ENOG4105F32 YngK protein BS467_14710 ENOG4105C1G acyl-Coa dehydrogenase BS467_14715 ENOG4105CEY Amp-dependent synthetase and ligase BS467_14720 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BS467_14725 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BS467_14730 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BS467_14735 ENOG4105E39 Enoyl-CoA hydratase BS467_14740 ENOG4107QX3 carboxylase BS467_14745 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BS467_14755 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BS467_14780 ENOG4107RZC phospholipase d BS467_14785 ENOG4105HX0 Transcriptional regulator BS467_14790 ENOG4105DE4 1-phosphofructokinase BS467_14795 ENOG4105DM4 PTS System BS467_14800 ENOG4105DM4 PTS System BS467_14825 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BS467_14830 ENOG4105KD7 acetyltransferase BS467_14840 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia BS467_14855 ENOG4105UP7 3-epimerase BS467_14870 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BS467_14875 ENOG4105I1K ABC transporter BS467_14890 ENOG4107SYN Glycosyl hydrolases family 43 BS467_14900 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BS467_14915 ENOG4108Z6Z Transcriptional regulator BS467_14935 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) BS467_14950 ENOG4105KME endoribonuclease L-psp BS467_14955 ENOG4105C6T cysteine synthase BS467_14960 ENOG4105KVH Transcriptional regulator BS467_14965 ENOG4105DYS nad(p)h dehydrogenase (quinone) BS467_14980 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BS467_14985 ENOG4107ZXU DSBA oxidoreductase BS467_14995 ENOG41082YX Transcriptional regulator, arsr family BS467_15000 ENOG4107R5R arsenical pump membrane protein BS467_15005 ENOG4108UXE Protein tyrosine phosphatase BS467_15020 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BS467_15025 ENOG4106UW1 Major Facilitator superfamily BS467_15040 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BS467_15045 ENOG4105K4P CoA-binding domain protein BS467_15050 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BS467_15055 ENOG4105W8X HesB YadR YfhF-family protein BS467_15060 ENOG4105MI2 BS467_15085 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BS467_15090 ENOG4108I0Z Aconitate hydratase BS467_15120 ENOG4107QIV Cytochrome c biogenesis protein BS467_15130 ENOG4105VXM UPF0154 protein BS467_15140 ENOG4105CV1 Transketolase (EC 2.2.1.1) BS467_15145 ENOG4105VPS UPF0291 protein BS467_15150 ENOG4108SVB resolvase BS467_15160 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BS467_15175 ENOG4106SCS STAS domain BS467_15180 ENOG4105WFK nuclease BS467_15185 ENOG4105EDW glycosyl transferase, family 39 BS467_15190 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases BS467_15195 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BS467_15200 ENOG41082JN Transcriptional regulator BS467_15205 ENOG4108QY0 Membrane BS467_15225 ENOG41080R8 Conserved Protein BS467_15230 ENOG4107QR9 Iron-sulfur cluster binding protein BS467_15235 ENOG4107R5T Cysteine-rich domain BS467_15245 ENOG4105ECR NmrA family BS467_15250 ENOG4108Z40 Transcriptional regulator BS467_15260 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) BS467_15265 ENOG4105FDF Could be involved in DNA repair (By similarity) BS467_15270 ENOG4105DQE DNA ligase BS467_15275 ENOG4105XPP Protein of unknown function (DUF1275) BS467_15285 ENOG410780I phosphoprotein phosphatase activity BS467_15305 ENOG4108ZMX Domain of unknown function (DU1801) BS467_15355 ENOG410780I phosphoprotein phosphatase activity BS467_15380 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BS467_15385 ENOG4105C5F glutamine synthetase BS467_15390 ENOG4105KV4 Transcriptional regulator BS467_15395 ENOG4105CXI aluminum resistance protein BS467_15400 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BS467_15405 ENOG4106F1P AAA ATPase, central domain protein BS467_15415 ENOG4105U6W MutT NUDIX family protein BS467_15420 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BS467_15425 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BS467_15430 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BS467_15450 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BS467_15475 ENOG410814C multidrug resistance protein BS467_15480 ENOG4108X3M OsmC Ohr family protein BS467_15485 ENOG4105K7W phage-related replication protein BS467_15490 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BS467_15500 ENOG4105K7W phage-related replication protein BS467_15505 ENOG4108VJ1 Transcriptional regulator (CarD family BS467_15530 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BS467_15535 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BS467_15550 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BS467_15560 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BS467_15565 ENOG4105CPQ Dehydrogenase BS467_15575 ENOG4105MCT stage V sporulation protein S BS467_15580 ENOG4105D48 metallophosphoesterase BS467_15585 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) BS467_15590 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BS467_15595 ENOG4105CEV competence damage-inducible protein BS467_15600 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BS467_15615 ENOG4105XZV Protein of unknown function (DUF3243) BS467_15620 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BS467_15625 ENOG4105EYF MMPL domain protein BS467_15645 ENOG4105EYF MMPL domain protein BS467_15655 ENOG4105FDP GntR family transcriptional regulator BS467_15660 ENOG4105CNU cell division protein FtsK BS467_15670 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BS467_15680 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BS467_15690 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BS467_15695 ENOG4108S0H Dipicolinic acid synthetase, b subunit BS467_15700 ENOG4105E35 Dipicolinate synthase subunit A BS467_15715 ENOG4105C1V Peptidase, M16 BS467_15725 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BS467_15730 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BS467_15735 ENOG4105DTN riboflavin biosynthesis protein ribF BS467_15740 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BS467_15745 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BS467_15750 ENOG4105W7A Protein of unknown function (DUF503) BS467_15755 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BS467_15760 ENOG4105VHM ribosomal protein BS467_15765 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BS467_15770 ENOG4105CHV Transcription elongation factor NusA BS467_15775 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BS467_15790 ENOG4105WJF BS467_15795 ENOG4105CYP glycoside hydrolase, family BS467_15805 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BS467_15810 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BS467_15815 ENOG4105DZP Membrane-associated zinc metalloprotease BS467_15820 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BS467_15825 ENOG4105KNE Phosphatidate cytidylyltransferase BS467_15830 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BS467_15835 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BS467_15845 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BS467_15850 ENOG4105CE9 30S ribosomal protein S2 BS467_15860 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS467_15865 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BS467_15875 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BS467_15880 ENOG4105CBS Chea signal transduction histidine kinase BS467_15885 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BS467_15895 ENOG4105FZW flagellar biosynthesis regulator FlhF BS467_15900 ENOG4105D7B Flagellar biosynthesis protein flha BS467_15905 ENOG4105D00 flagellar biosynthetic protein flhB BS467_15910 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BS467_15915 ENOG4105VS8 Flagellar biosynthetic protein fliq BS467_15920 ENOG4105CN7 Flagellar biosynthetic protein FliP BS467_15930 ENOG4107YTP response regulator receiver protein BS467_15935 ENOG4105DD5 Flagellar motor switch protein BS467_15940 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BS467_15950 ENOG41068WV flagellar FlbD family protein BS467_15955 ENOG4108JQA flagellar BS467_15960 ENOG410822I Flagellar hook capping protein BS467_15965 ENOG410696Y Flagellar hook-length control protein BS467_15975 ENOG4106YF4 Flagellar biosynthesis chaperone BS467_15990 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BS467_15995 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BS467_16000 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BS467_16005 ENOG4108ZC9 flagellar basal-body rod protein flgc BS467_16010 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BS467_16020 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BS467_16025 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BS467_16030 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BS467_16035 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BS467_16040 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BS467_16045 ENOG4105C79 DNA protecting protein DprA BS467_16050 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BS467_16055 ENOG4105CMV Succinyl-CoA synthetase subunit beta BS467_16060 ENOG4105VM1 flagellar BS467_16070 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BS467_16075 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BS467_16080 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BS467_16085 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BS467_16090 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BS467_16100 ENOG4108BW8 UPF0109 protein BS467_16105 ENOG4105K5M 30s ribosomal protein S16 BS467_16115 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BS467_16125 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BS467_16130 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BS467_16135 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BS467_16140 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BS467_16145 ENOG4105CHR reductase BS467_16150 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BS467_16155 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BS467_16160 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BS467_16165 ENOG4105CB5 ATP-dependent DNA helicase recG BS467_16170 ENOG4105EJQ L-serine dehydratase BS467_16180 ENOG4105DP4 dak2 domain fusion protein ylov BS467_16185 ENOG4108ZAA Alkaline-shock protein BS467_16190 ENOG4105VB9 50S ribosomal protein l28 BS467_16200 ENOG4105FJ0 thiamine BS467_16205 ENOG4105DJV ribulose-phosphate 3-epimerase BS467_16210 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BS467_16215 ENOG4105D9P serine threonine protein kinase BS467_16220 ENOG4108ZF3 Phosphatase BS467_16225 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BS467_16230 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BS467_16235 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BS467_16240 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BS467_16245 ENOG4105C25 Primosomal protein n' BS467_16250 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BS467_16260 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BS467_16265 ENOG4105KC4 UPF0296 protein BS467_16270 ENOG4105DSJ YicC domain protein BS467_16280 ENOG4105F23 Fibronectin-binding protein BS467_16285 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BS467_16290 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BS467_16295 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BS467_16300 ENOG4108WF4 Catalyzes the synthesis of activated sulfate (By similarity) BS467_16305 ENOG4107RIQ Sulfate adenylate transferase BS467_16315 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BS467_16325 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BS467_16330 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BS467_16335 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BS467_16340 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BS467_16345 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BS467_16350 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BS467_16355 ENOG4105CD3 dihydroorotase BS467_16360 ENOG4105CXT aspartate transcarbamylase BS467_16370 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BS467_16375 ENOG4105C34 Pseudouridine synthase BS467_16380 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BS467_16390 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BS467_16400 ENOG4105DBK s4 domain protein BS467_16405 ENOG41067XK integral membrane protein BS467_16410 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BS467_16415 ENOG4105DFA alanine racemase domain protein BS467_16420 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BS467_16425 ENOG4105WR5 sporulation protein, YlmC YmxH family BS467_16430 ENOG4105DKW ABC transporter BS467_16435 ENOG4105VI0 Pts system, glucitol sorbitol-specific BS467_16440 ENOG4105DZY Pts system, glucitol sorbitol-specific BS467_16445 ENOG410787A Pts system, glucitol sorbitol-specific BS467_16460 ENOG4105DKT Transcriptional regulator BS467_16470 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS467_16475 ENOG4105FFI sigma-e processing peptidase spoiiga BS467_16485 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BS467_16490 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BS467_16495 ENOG4105K67 small basic protein BS467_16505 ENOG4108R2U division initiation protein BS467_16510 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BS467_16515 ENOG4105D4A Cell wall formation (By similarity) BS467_16520 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BS467_16525 ENOG4105CNI cell division protein FtsW BS467_16530 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BS467_16535 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BS467_16540 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BS467_16545 ENOG4105CJN penicillin-binding protein BS467_16550 ENOG4105CJN penicillin-binding protein BS467_16560 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BS467_16565 ENOG4108V6E Cell division protein mraZ BS467_16590 ENOG41067VY 50S ribosomal protein L32 BS467_16595 ENOG4105KNH Nucleic acid-binding protein BS467_16600 ENOG4105CDE UPF0348 protein BS467_16605 ENOG41063PX domain protein BS467_16610 ENOG4105D78 K07001 NTE family protein BS467_16615 ENOG4105H20 Sporulation integral membrane protein YlbJ BS467_16620 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BS467_16625 ENOG4106H78 methyltransferase BS467_16630 ENOG4105WUC UPF0298 protein BS467_16655 ENOG4106UY4 Inherit from COG: Scp-like extracellular BS467_16660 ENOG41080XQ Signal transduction protein with cbs domains BS467_16675 ENOG41064X9 cytochrome C oxidase subunit IV BS467_16680 ENOG4105CCU oxidase (Subunit III) BS467_16685 ENOG4105BZ9 Cytochrome C oxidase, subunit I BS467_16695 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BS467_16705 ENOG4105CVP deoxyribo-dipyrimidine photolyase BS467_16710 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BS467_16715 ENOG4105CNI cell division protein FtsW BS467_16725 ENOG4105CSV Glutaminase BS467_16735 ENOG4108IAB Phoh family BS467_16750 ENOG4105QA2 BS467_16755 ENOG4105CI3 gtp-binding protein typa BS467_16790 ENOG4105ECY inositol monophosphatase BS467_16800 ENOG4108WQ8 UPF0637 protein BS467_16810 ENOG4105CXN decarboxylase BS467_16830 ENOG4107QN2 dihydrolipoyl dehydrogenase BS467_16835 ENOG4105C7S Dehydrogenase BS467_16840 ENOG4105CPP Dehydrogenase, E1 component BS467_16860 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BS467_16865 ENOG4108X4Q Hydrolase BS467_16875 ENOG4105CN5 Metallo-Beta-Lactamase BS467_16880 ENOG4105CPN adenine deaminase BS467_16885 ENOG4107ZYR domain protein BS467_16895 ENOG4105BZU Histidine kinase BS467_16915 ENOG4105C5H ABC transporter BS467_16925 ENOG4105C3F Signal peptidase i BS467_16930 ENOG4105DM4 PTS System BS467_16935 ENOG4105DE4 1-phosphofructokinase BS467_16940 ENOG4105E98 transcriptional regulator DeoR family BS467_16945 ENOG4107RBB ABC transporter, permease BS467_16950 ENOG4105C19 ABC transporter BS467_16955 ENOG4107X8C Efflux transporter RND family MFP subunit BS467_16970 ENOG41067WU Molybdopterin converting factor (Subunit 1) BS467_16975 ENOG4108ZAF Molybdopterin BS467_16980 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BS467_16985 ENOG4105CVM Molybdenum cofactor synthesis domain protein BS467_16990 ENOG4105D06 uba thif-type nad fad binding protein BS467_16995 ENOG41080QG Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BS467_17010 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BS467_17020 ENOG4105D3R alkyl hydroperoxide reductase BS467_17025 ENOG4105D8X mechanosensitive ion channel BS467_17030 ENOG4106AUC UPF0180 protein BS467_17040 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BS467_17045 ENOG4105NQC Flavodoxin BS467_17080 ENOG4108XRC Protein of unknown function (DUF458) BS467_17085 ENOG4107IN1 Protein of unknown function (DUF1797) BS467_17090 ENOG4105WEF catalase BS467_17095 ENOG4105EPM Diguanylate phosphodiesterase BS467_17100 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BS467_17110 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein BS467_17130 ENOG4105UIN BS467_17140 ENOG4107R88 Chemotaxis protein (CheV) BS467_17150 ENOG41085PJ rdd domain containing protein BS467_17160 ENOG4105CHM Aminotransferase BS467_17175 ENOG4105K4I Scp-like extracellular BS467_17180 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BS467_17185 ENOG4105CHR reductase BS467_17190 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BS467_17195 ENOG4105F6S Spore photoproduct lyase BS467_17205 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BS467_17210 ENOG4105KRI phosphocarrier protein (HPr BS467_17220 ENOG4105CID antiterminator BS467_17230 ENOG4105DC7 peptidase M24 BS467_17235 ENOG4105C59 p-type ATPase BS467_17250 ENOG4105F0V Cell wall hydrolase BS467_17270 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BS467_17275 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BS467_17280 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BS467_17285 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BS467_17290 ENOG4108K88 Membrane BS467_17305 ENOG4105E14 MotA TolQ exbB proton channel BS467_17310 ENOG4105ER2 Ompa motb domain protein BS467_17315 ENOG41090MY MarR family Transcriptional regulator BS467_17320 ENOG4105BZU Histidine kinase BS467_17330 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BS467_17335 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BS467_17340 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BS467_17345 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BS467_17355 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BS467_17360 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BS467_17365 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BS467_17370 ENOG4105BZU Histidine kinase BS467_17375 ENOG4108TGC Acyltransferase BS467_17385 ENOG410900G Protein of unknown function (DUF421) BS467_17395 ENOG4105D0M Protease HtpX homolog BS467_17405 ENOG410681C small acid-soluble spore protein BS467_17415 ENOG4108WZW RNA polymerase sigma BS467_17420 ENOG4107TS3 membrane protein, TerC BS467_17425 ENOG4107T5V SNARE associated Golgi BS467_17430 ENOG4105BZU Histidine kinase BS467_17455 ENOG4105V75 Transcriptional regulator BS467_17475 ENOG4105CJW magnesium transporter BS467_17485 ENOG4106849 propeptide, pepSY amd peptidase M4 BS467_17495 ENOG41062D9 Histidine kinase BS467_17500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS467_17515 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BS467_17520 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BS467_17525 ENOG4107Y2X deaminase BS467_17530 ENOG4108ZHJ Organic hydroperoxide resistance protein BS467_17535 ENOG4105K56 Transcriptional regulator BS467_17555 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BS467_17560 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BS467_17565 ENOG4105CIY formyltetrahydrofolate deformylase BS467_17575 ENOG41080TC multidrug resistance protein BS467_17580 ENOG410839T multidrug resistance protein BS467_17585 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BS467_17590 ENOG4108428 Inherit from COG: -acetyltransferase BS467_17610 ENOG4105K7K Transcriptional regulator BS467_17615 ENOG4108S4H thioesterase Superfamily protein BS467_17620 ENOG4107TUM Amidinotransferase BS467_17625 ENOG4108JQ7 (ABC) transporter BS467_17630 ENOG4107SN7 NLP P60 protein BS467_17635 ENOG4105DTQ mandelate racemase muconate lactonizing BS467_17640 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BS467_17655 ENOG4105C3U ABC transporter BS467_17660 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BS467_17665 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BS467_17670 ENOG4108ME1 Peptidase M55 D-aminopeptidase BS467_17680 ENOG4105C0H protease BS467_17690 ENOG4107R7I amino acid BS467_17700 ENOG4107RHR regulatoR BS467_17705 ENOG4105CHR reductase BS467_17710 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BS467_17720 ENOG4107QKR Dehydrogenase BS467_17725 ENOG4105CPP Dehydrogenase, E1 component BS467_17730 ENOG4107RUY (E1 component), alpha subunit BS467_17750 ENOG4105DT3 PTS system, galactitol-specific IIc component BS467_17760 ENOG4108IJ6 ABC transporter BS467_17765 ENOG4105ECW sulfate abc transporter BS467_17770 ENOG4108I5D sulfate abc transporter BS467_17775 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BS467_17780 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BS467_17790 ENOG4107GRR phosphate transport regulator BS467_17795 ENOG4105CJ3 phosphate transporter BS467_17810 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BS467_17815 ENOG410635T phage-like element pbsx protein BS467_17820 ENOG4105K7W phage-related replication protein BS467_17840 ENOG4105I03 Flagellin BS467_17845 ENOG4105I03 Flagellin BS467_17855 ENOG4105PF9 Transcriptional regulator BS467_17865 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BS467_17875 ENOG4105K5X acetyltransferase BS467_17890 ENOG4105DJ2 Major Facilitator Superfamily BS467_17895 ENOG4107V2S Transcriptional regulator BS467_17915 ENOG4105DUM transcriptional regulator, lysR family BS467_17935 ENOG4105E1F short-chain dehydrogenase reductase BS467_17955 ENOG41082BV acetyltransferase BS467_17995 ENOG4105C28 cystathionine BS467_18000 ENOG4105C28 cystathionine BS467_18025 ENOG4105ENA helicase BS467_18075 ENOG4107A88 BS467_18080 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BS467_18085 ENOG4105DWF phosphomethylpyrimidine kinase BS467_18090 ENOG4105D06 uba thif-type nad fad binding protein BS467_18095 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BS467_18110 ENOG4108VEU Thiamine monophosphate synthase BS467_18115 ENOG4105ETU transcriptional activator (TenA BS467_18125 ENOG4107S1Q Phosphatase BS467_18130 ENOG4105EMS pseudouridine synthase BS467_18135 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BS467_18145 ENOG4106EFP UPF0738 protein BS467_18150 ENOG4105MIX Adenylate cyclase BS467_18155 ENOG4105E4C Lytic transglycosylase catalytic BS467_18160 ENOG4108Z18 K06886 hemoglobin BS467_18165 ENOG4105T58 Dithiol-disulfide isomerase BS467_18170 ENOG4105DPN Oligoendopeptidase f BS467_18180 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BS467_18185 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BS467_18190 ENOG4108ZCF integral membrane protein BS467_18195 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BS467_18210 ENOG4108JQ7 (ABC) transporter BS467_18220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BS467_18225 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BS467_18245 ENOG4105C31 Tryptophanyl-tRNA synthetase BS467_18255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BS467_18270 ENOG4108JQ7 (ABC) transporter BS467_18275 ENOG4105C3U ABC transporter BS467_18285 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BS467_18290 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BS467_18310 ENOG4107RMD Basic membrane lipoprotein BS467_18340 ENOG4105DBV ornithine carbamoyltransferase BS467_18350 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BS467_18355 ENOG4105C8Y Acetylornithine aminotransferase BS467_18360 ENOG4105CAS nag kinase BS467_18370 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BS467_18380 ENOG4105IQ5 FAD linked oxidase domain protein BS467_18385 ENOG4105VG1 fes assembly suf system protein BS467_18390 ENOG4108MXZ Esterase BS467_18395 ENOG4108KP7 hydrolase BS467_18405 ENOG41073B9 BS467_18415 ENOG4107AYK membrAne BS467_18420 ENOG4105EPR degv family BS467_18425 ENOG4105C8Q Methyl-accepting chemotaxis BS467_18430 ENOG4105DIH basic membrane BS467_18440 ENOG4105QNR S1 RNA binding domain protein BS467_18445 ENOG4108VPT UPF0234 protein BS467_18490 ENOG4105DY8 decarboxylase BS467_18515 ENOG4106HBX Transcriptional Regulator AraC Family BS467_18520 ENOG4105UQX Mate efflux family protein BS467_18545 ENOG4105CAQ asparagine synthetase BS467_18555 ENOG4106BKT UPF0344 protein BS467_18560 ENOG4105ERH Fumarylacetoacetate hydrolase BS467_18620 ENOG4105EYH Exonuclease BS467_18630 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BS467_18660 ENOG4108KK1 membrane protein AbrB duplication BS467_18675 ENOG41060YP BS467_18685 ENOG4108KGH TRANSCRIPTIONal BS467_18695 ENOG4108IPW abc transporter atp-binding protein BS467_18700 ENOG4105CM4 permease protein BS467_18705 ENOG4105DHS permease protein BS467_18710 ENOG41067XF inhibitor BS467_18715 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS467_18720 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BS467_18735 ENOG4105XVF Competence transcription factor BS467_18755 ENOG4106YBV Methyl-accepting chemotaxis BS467_18760 ENOG4107TB6 phosphoglycerate mutase BS467_18765 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BS467_18770 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BS467_18785 ENOG4105CEY Amp-dependent synthetase and ligase BS467_18790 ENOG4105DF9 Lipoate-protein, ligase BS467_18795 ENOG4108RQ5 Beta-lactamase domain-containing protein BS467_18800 ENOG4106AXD BS467_18810 ENOG4105DER m42 family BS467_18820 ENOG4105ECB domain protein BS467_18830 ENOG4105C1Q protoporphyrinogen oxidase BS467_18835 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BS467_18840 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BS467_18845 ENOG4105BZ4 penicillin-binding protein BS467_18850 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BS467_18880 ENOG4105K59 histidine triad (HIT) protein BS467_18885 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BS467_18890 ENOG4105NBU tryptophan transport protein BS467_18940 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BS467_18955 ENOG4106D4I domain protein BS467_18960 ENOG4107VRP DNA repair exonuclease BS467_18970 ENOG4105CGU Enoyl-CoA hydratase BS467_18980 ENOG4105NCW Trka-c domain protein BS467_18985 ENOG4107S91 Sodium hydrogen exchanger BS467_18995 ENOG4105D4P Coproporphyrinogen iii oxidase BS467_19005 ENOG4105WZB UPF0342 protein BS467_19010 ENOG4108UH6 UPF0754 membrane protein BS467_19020 ENOG410839P BS467_19050 ENOG4105BZ1 (ABC) transporter BS467_19055 ENOG4105BZ1 (ABC) transporter BS467_19065 ENOG4105F0I Aminotransferase BS467_19070 ENOG4107VMI polysaccharide deacetylase BS467_19075 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BS467_19080 ENOG4105D64 Mechanosensitive ion channel BS467_19085 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BS467_19090 ENOG4105WMR Protein CrcB homolog BS467_19095 ENOG4106A8V Protein CrcB homolog BS467_19105 ENOG4105C37 (CBS) domain BS467_19115 ENOG4105C37 (CBS) domain BS467_19120 ENOG4105F6E Acyl-transferase BS467_19125 ENOG4108AEY RNA polymerase sigma factor BS467_19130 ENOG4105J37 BS467_19140 ENOG4105CUB amino acid BS467_19150 ENOG4105G6Z alkaline phosphatase BS467_19155 ENOG4105ED1 spovr family BS467_19160 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BS467_19165 ENOG4105KPV Transcriptional regulator BS467_19170 ENOG4105CH6 catalase BS467_19185 ENOG4105WH1 Two component transcriptional regulator luxr family BS467_19190 ENOG4105BZU Histidine kinase BS467_19200 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BS467_19205 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BS467_19215 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BS467_19220 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BS467_19225 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BS467_19245 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BS467_19250 ENOG4107YBY Hydrolase BS467_19260 ENOG4108YBP pseudouridine synthase BS467_19275 ENOG4105BZU Histidine kinase BS467_19305 ENOG4105BZU Histidine kinase BS467_19315 ENOG4105VEQ Cold shock protein BS467_19325 ENOG4105CS1 NAD(P)H quinone oxidoreductase BS467_19330 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS467_19335 ENOG4105CW7 secretion protein, HlyD family BS467_19340 ENOG4106AKX UPF0229 protein BS467_19345 ENOG4105CYN Serine protein kinase BS467_19350 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BS467_19360 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BS467_19395 ENOG4105CJ1 ABC, transporter BS467_19410 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BS467_19415 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BS467_19420 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BS467_19425 ENOG4105E2Y ABC, transporter BS467_19445 ENOG4105E0M Sulfatase