locus-tag class description BCA_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BCA_0003 ENOG410848D S4 domain protein YaaA BCA_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BCA_0014 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BCA_0021 ENOG4105ZMH deoxynucleoside kinase BCA_0023 ENOG4105GTG Isochorismatase BCA_0024 ENOG4108Z6B deaminase BCA_0026 ENOG4105C6E dna polymerase iii BCA_0030 ENOG41067KS pro-sigma K processing BCA_0038 ENOG4105CXN decarboxylase BCA_0040 ENOG4105FA2 dna polymerase iii BCA_0041 ENOG4105MA4 psp1 domain protein BCA_0043 ENOG41060K3 Methyltransferase BCA_0045 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BCA_0046 ENOG4105KRN Transcriptional regulator, abrb family BCA_0048 ENOG4105F8V Hydrolase, tatD family BCA_0049 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BCA_0051 ENOG4105XFA sporulation peptidase YabG BCA_0052 ENOG4105W42 Veg protein BCA_0055 ENOG4105DFT pur operon repressor BCA_0057 ENOG4105KME endoribonuclease L-psp BCA_0060 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BCA_0061 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BCA_0063 ENOG4108JA2 transcriptioN-repair coupling factor BCA_0064 ENOG4108M14 stage v sporulation protein t BCA_0066 ENOG4108IY2 MazG family BCA_0067 ENOG41082I2 s4 domain protein BCA_0068 ENOG4105VYY sporulation protein yabp BCA_0071 ENOG41060GV RNA binding s1 domain protein BCA_0076 ENOG4108UGV hypoxanthine phosphoribosyltransferase BCA_0077 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BCA_0080 ENOG4105C6T cysteine synthase BCA_0081 ENOG4105CRQ synthase (Component I) BCA_0082 ENOG4105DDQ anthranilate synthase BCA_0083 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BCA_0084 ENOG4105EEI dihydropteroate synthase BCA_0085 ENOG4105KRF dihydroneopterin aldolase BCA_0086 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BCA_0088 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BCA_0108 ENOG4108Z0C Uvrb UvrC protein BCA_0111 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BCA_0113 ENOG4105CTP PilT protein domain protein BCA_0117 ENOG4105D7W serine acetyltransferase BCA_0120 ENOG4105C2N RNA methyltransferase TrmH family group 3 BCA_0121 ENOG4105M0M Tetracycline resistance protein BCA_0122 ENOG4105QIV RNA polymerase BCA_0124 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BCA_0130 ENOG4107Y49 methyltransferase BCA_0133 ENOG4105XPM ribosomal protein BCA_0154 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BCA_0159 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BCA_0161 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BCA_0163 ENOG41067V7 50S ribosomal protein L36 BCA_0169 ENOG4108JJB ABC transporter BCA_0170 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BCA_0171 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BCA_0177 ENOG4105D1F ATP-binding protein BCA_0180 ENOG4108NMV polysaccharide deacetylase BCA_0197 ENOG4105C8B TIGR00159 family BCA_0198 ENOG4107U5W ybbr family BCA_0205 ENOG4105CMG Carbohydrate kinase BCA_0207 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BCA_0208 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BCA_0214 ENOG4108PSK reductase BCA_0215 ENOG4108UMI ABC transporter, permease BCA_0216 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BCA_0217 ENOG4105D01 (LipO)protein BCA_0219 ENOG4105EE1 crotonyl-CoA reductase BCA_0221 ENOG4105IQ5 FAD linked oxidase domain protein BCA_0225 ENOG4105C2C drug resistance transporter, Bcr CflA BCA_0229 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BCA_0230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BCA_0231 ENOG4105C3U ABC transporter BCA_0232 ENOG4108JQ7 (ABC) transporter BCA_0237 ENOG4105U5Y Transcriptional regulator BCA_0239 ENOG4108J59 Extracellular solute-binding protein, family 5 BCA_0240 ENOG4108J59 Extracellular solute-binding protein, family 5 BCA_0244 ENOG4107XDY Nicotinamide Mononucleotide Transporter BCA_0246 ENOG4105E0C molybdate abc transporter BCA_0247 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BCA_0249 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BCA_0253 ENOG4105F6E Acyl-transferase BCA_0256 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BCA_0259 ENOG4108RE7 deoxyribonuclease BCA_0261 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BCA_0266 ENOG4105C5H ABC transporter BCA_0269 ENOG4105DEF Extracellular solute-binding protein, family 5 BCA_0271 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BCA_0272 ENOG4105C3U ABC transporter BCA_0273 ENOG4108JQ7 (ABC) transporter BCA_0274 ENOG410667J hydrolase BCA_0278 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BCA_0279 ENOG4105ERH Fumarylacetoacetate hydrolase BCA_0281 ENOG4108SC4 )-transporter BCA_0282 ENOG4105CPF Cell wall formation (By similarity) BCA_0283 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BCA_0285 ENOG4107ZXI Rhomboid family BCA_0288 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BCA_0289 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BCA_0291 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BCA_0311 ENOG4105K8N protein family UPF0079, ATPase BCA_0312 ENOG41072GX Peptidase M22 Glycoprotease BCA_0313 ENOG410801F ribosomal-protein-alanine acetyltransferase BCA_0315 ENOG4105C5H ABC transporter BCA_0318 ENOG4108TYN CAAX amino terminal protease family protein BCA_0321 ENOG4107EV6 Inherit from COG: YD repeat protein BCA_0326 ENOG4105C7N Xanthine uracil vitamin C permease BCA_0328 ENOG4105BZU Histidine kinase BCA_0334 ENOG4107ZXU DSBA oxidoreductase BCA_0349 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BCA_0354 ENOG4105SX7 Transporter BCA_0362 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BCA_0363 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BCA_0364 ENOG4105C83 adenylosuccinate lyase BCA_0366 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BCA_0371 ENOG4108V3E phosphoribosylglycinamide formyltransferase BCA_0373 ENOG4105C12 Phosphoribosylglycinamide synthetase BCA_0378 ENOG4105C4R Atp-dependent dna helicase BCA_0384 ENOG4108W2Y isochorismatase BCA_0386 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BCA_0387 ENOG4108UMI ABC transporter, permease BCA_0388 ENOG4105D01 (LipO)protein BCA_0391 ENOG410834F Transcriptional regulator BCA_0396 ENOG4105CBD Diacylglycerol kinase BCA_0397 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BCA_0398 ENOG4108JPW Aminotransferase BCA_0400 ENOG4105C26 Dehydrogenase BCA_0401 ENOG4105KPY Small multidrug resistance protein BCA_0405 ENOG4105D9N nucleoside BCA_0407 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BCA_0409 ENOG4105BZU Histidine kinase BCA_0410 ENOG4108W15 Protein of unknown function (DUF1456) BCA_0413 ENOG4105DTQ mandelate racemase muconate lactonizing BCA_0414 ENOG4105DFD Na H antiporter BCA_0419 ENOG4105D3R alkyl hydroperoxide reductase BCA_0420 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BCA_0422 ENOG4107W7X Aldolase BCA_0423 ENOG4105EHG Permease protein BCA_0424 ENOG4105DQ5 transport system permease protein BCA_0430 ENOG4106UIA BCA_0439 ENOG410756H nucleotidyltransferase BCA_0440 ENOG4105D2S major facilitator superfamily BCA_0443 ENOG4105E5Q amino acid AbC transporter BCA_0444 ENOG4105EAB amino acid AbC transporter BCA_0446 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BCA_0448 ENOG4105CI1 PTS System BCA_0456 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BCA_0460 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BCA_0464 ENOG4105C5H ABC transporter BCA_0470 ENOG41062JF Transcriptional regulator BCA_0474 ENOG4105DEU major facilitator superfamily BCA_0480 ENOG4108N0M stress protein BCA_0481 ENOG4106FN3 tellurium resistance protein BCA_0482 ENOG4106FN3 tellurium resistance protein BCA_0483 ENOG4107TS3 membrane protein, TerC BCA_0484 ENOG4108TTB tellurium resistance protein BCA_0488 ENOG4105KJF protein tyrosine phosphatase BCA_0490 ENOG4107U9T Pfam:Ribonuclease_BN BCA_0491 ENOG4105C59 p-type ATPase BCA_0492 ENOG4108IPJ Membrane BCA_0496 ENOG4107ZTW SNARE associated Golgi BCA_0499 ENOG410606W general stress protein BCA_0500 ENOG4105UPD Calcium Proton BCA_0510 ENOG4108JUB Transcriptional regulator BCA_0513 ENOG4108IQI permease BCA_0521 ENOG4108A04 Beta-lactamase BCA_0524 ENOG4105CKK Glycosyl transferase, family 2 BCA_0525 ENOG4107QQG Dehydrogenase BCA_0526 ENOG4105C3I Nad-dependent epimerase dehydratase BCA_0529 ENOG4105F1A Pyruvate formate-lyase BCA_0533 ENOG4105CI2 imidazolone-5-propionate hydrolase BCA_0534 ENOG4105ECP epimerase BCA_0540 ENOG41067AE Membrane-bound metal-dependent hydrolase BCA_0541 ENOG4105CEN a g-specific adenine glycosylase BCA_0542 ENOG4106BXE BCA_0547 ENOG4105BZ1 (ABC) transporter BCA_0548 ENOG4107NBY Membrane BCA_0549 ENOG4105CBC glutamate synthase BCA_0551 ENOG4108IUW ABC transporter BCA_0555 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BCA_0556 ENOG4105G5W regulator Fur family BCA_0580 ENOG4108JQC penicillin-binding protein 1A BCA_0581 ENOG4107ZQN disulfide bond BCA_0583 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BCA_0585 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BCA_0586 ENOG4105BZU Histidine kinase BCA_0587 ENOG4105CYN Serine protein kinase BCA_0590 ENOG4105C94 Transporter BCA_0593 ENOG4105DZ6 Band 7 protein BCA_0595 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BCA_0596 ENOG4108V9W transcriptional regulatory protein BCA_0597 ENOG4105D4T Citrate transporter BCA_0601 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BCA_0602 ENOG4108STX response regulator BCA_0603 ENOG4105US7 Histidine kinase BCA_0608 ENOG4108MRH transcriptional regulatory protein BCA_0610 ENOG4105C6K Malic enzyme BCA_0612 ENOG4108UZ3 Transporter BCA_0613 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BCA_0615 ENOG4105BZU Histidine kinase BCA_0616 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCA_0619 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BCA_0620 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BCA_0621 ENOG4108JB9 formate dehydrogenase BCA_0626 ENOG4105CUB amino acid BCA_0628 ENOG4105C59 p-type ATPase BCA_0629 ENOG4105DAP Nicotinate phosphoribosyltransferase BCA_0636 ENOG41073R8 VanW family BCA_0637 ENOG4108KGH TRANSCRIPTIONal BCA_0638 ENOG4105D9N nucleoside BCA_0639 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BCA_0640 ENOG4105C37 (CBS) domain BCA_0641 ENOG4108IJ0 Aspartate ammonia-lyase BCA_0642 ENOG4105DAA L-lactate BCA_0648 ENOG4105DUX Transporter BCA_0649 ENOG4108MES Periplasmic binding protein BCA_0650 ENOG4105DQ5 transport system permease protein BCA_0651 ENOG4108IHU transport system permease protein BCA_0652 ENOG4105E0A ABC, transporter BCA_0653 ENOG4105DMQ Methyltransferase BCA_0655 ENOG4105EXW epimerase dehydratase BCA_0656 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BCA_0658 ENOG4107T89 von Willebrand factor, type A BCA_0659 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BCA_0660 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BCA_0662 ENOG4105BZU Histidine kinase BCA_0663 ENOG4105D5Q Arginine ornithine antiporter BCA_0664 ENOG4107414 GntR family transcriptional regulator BCA_0665 ENOG4105C5Y PTS System BCA_0666 ENOG4105CG3 alpha amylase, catalytic region BCA_0669 ENOG4105E1K spore germination protein BCA_0670 ENOG4108XG2 Histidine kinase BCA_0671 ENOG4105WH1 Two component transcriptional regulator luxr family BCA_0672 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BCA_0675 ENOG4105CRN Aminoglycoside phosphotransferase BCA_0676 ENOG4105BZG amino acid carrier protein BCA_0677 ENOG4105CDA abc transporter atp-binding protein BCA_0678 ENOG4105CT1 (ABC) transporter BCA_0679 ENOG4105EAD ABC transporter BCA_0680 ENOG4105DRP amino acid AbC transporter BCA_0681 ENOG4108IQI permease BCA_0686 ENOG4105D29 Helix-turn-helix type 11 domain protein BCA_0687 ENOG4105NAE bifunctional deaminase-reductase domain protein BCA_0688 ENOG4105BZU Histidine kinase BCA_0691 ENOG4105CHH sulfate transporter BCA_0692 ENOG41068KF Universal stress protein BCA_0694 ENOG4105DEF Extracellular solute-binding protein, family 5 BCA_0696 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BCA_0697 ENOG4108JQ7 (ABC) transporter BCA_0699 ENOG4105CXY transporter BCA_0700 ENOG41067TZ transcriptional regulator, MarR family BCA_0701 ENOG4105C0R drug resistance transporter emrb qaca subfamily BCA_0702 ENOG4105ETE Transcriptional regulator (LacI family BCA_0703 ENOG4108RVA ribokinase BCA_0705 ENOG4105C2J ABC transporter BCA_0706 ENOG4105CNN ABC, transporter BCA_0707 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BCA_0708 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BCA_0720 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BCA_0721 ENOG41069ER domain protein BCA_0722 ENOG4105VZ8 Transcriptional regulator BCA_0723 ENOG4107D63 BCA_0725 ENOG4105DUX Transporter BCA_0730 ENOG4105C85 amino acid BCA_0731 ENOG4105C7N Xanthine uracil vitamin C permease BCA_0734 ENOG4105MA6 gCN5-related N-acetyltransferase BCA_0740 ENOG4105BZ9 Cytochrome C oxidase, subunit I BCA_0741 ENOG4105E2S oxidase) subunit II BCA_0744 ENOG4106CAD Protein of unknown function (DUF3311) BCA_0745 ENOG4105E1V na solute symporter BCA_0748 ENOG4108NHD germination protein BCA_0750 ENOG4105CE1 Ferrous iron transport protein b BCA_0752 ENOG4105CE1 Ferrous iron transport protein b BCA_0753 ENOG4105CVA phosphate BCA_0754 ENOG4105C8U phosphate abc transporter BCA_0755 ENOG4105E2Z phosphate ABC transporter (Permease BCA_0781 ENOG41080XQ Signal transduction protein with cbs domains BCA_0788 ENOG4105ETU transcriptional activator (TenA BCA_0790 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BCA_0792 ENOG4108VEU Thiamine monophosphate synthase BCA_0793 ENOG41080HI glycine oxidase BCA_0796 ENOG4105D06 uba thif-type nad fad binding protein BCA_0797 ENOG4105DWF phosphomethylpyrimidine kinase BCA_0808 ENOG4108INS Transcriptional regulator BCA_0813 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BCA_0815 ENOG4105C7N Xanthine uracil vitamin C permease BCA_0817 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BCA_0821 ENOG4105C5Y PTS System BCA_0828 ENOG4108B31 Spore germination protein BCA_0832 ENOG4107Y03 Nitroreductase BCA_0833 ENOG4105ED1 spovr family BCA_0835 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BCA_0836 ENOG41085GJ domain protein BCA_0837 ENOG4105XTG Pfam:DUF156 BCA_0838 ENOG4105VFE sira family BCA_0839 ENOG4107TPS domain protein BCA_0840 ENOG4105VFE sira family BCA_0841 ENOG41085GJ domain protein BCA_0843 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BCA_0844 ENOG41087NI Sulfite exporter TauE/SafE BCA_0846 ENOG4108KGH TRANSCRIPTIONal BCA_0851 ENOG4105EMD TRANSCRIPTIONal BCA_0852 ENOG4105VCP PTS System BCA_0853 ENOG4105VZJ PTS System BCA_0857 ENOG41069ER domain protein BCA_0858 ENOG4107RBB ABC transporter, permease BCA_0859 ENOG4105C19 ABC transporter BCA_0866 ENOG4105WEF catalase BCA_0874 ENOG4107T5V SNARE associated Golgi BCA_0881 ENOG4105CUB amino acid BCA_0882 ENOG4107RWR Sodium hydrogen exchanger BCA_0884 ENOG4106KNT transcriptional regulator BCA_0893 ENOG4108YXU transcriptional regulator AsnC family BCA_0895 ENOG4105KPY Small multidrug resistance protein BCA_0896 ENOG4105KPY Small multidrug resistance protein BCA_0899 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BCA_0900 ENOG4105E5W Transporter BCA_0902 ENOG4107RKG DJ-1/PfpI family BCA_0903 ENOG4105CH6 catalase BCA_0905 ENOG4105D5Q Arginine ornithine antiporter BCA_0907 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BCA_0909 ENOG4105C26 Dehydrogenase BCA_0910 ENOG4105BZ1 (ABC) transporter BCA_0911 ENOG4105BZ1 (ABC) transporter BCA_0913 ENOG4105DRP amino acid AbC transporter BCA_0914 ENOG4105CDA abc transporter atp-binding protein BCA_0917 ENOG410839P BCA_0924 ENOG4107FQX Alpha-acetolactate decarboxylase BCA_0927 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BCA_0928 ENOG4105D4P Coproporphyrinogen iii oxidase BCA_0931 ENOG4105CHH sulfate transporter BCA_0940 ENOG4106AKK s-layer domain-containing protein BCA_0942 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BCA_0944 ENOG4105CGU Enoyl-CoA hydratase BCA_0948 ENOG4105DER m42 family BCA_0952 ENOG4105CTU Proline racemase BCA_0957 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BCA_0959 ENOG4108JQ7 (ABC) transporter BCA_0965 ENOG4105CSH Transporter BCA_0967 ENOG4108MRH transcriptional regulatory protein BCA_0975 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 BCA_0981 ENOG4105CDU Replicative dna helicase BCA_0986 ENOG4105C0R drug resistance transporter emrb qaca subfamily BCA_0995 ENOG4107P5I polyketide synthase BCA_0996 ENOG4108IG5 Transcriptional regulator BCA_0999 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BCA_1005 ENOG4105CMT Dihydroxyacetone kinase BCA_1007 ENOG4105CMT Dihydroxyacetone kinase BCA_1008 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BCA_1009 ENOG410847I Transcriptional regulator, BadM Rrf2 family BCA_1012 ENOG410780I phosphoprotein phosphatase activity BCA_1014 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BCA_1027 ENOG4105WN5 stage II sporulation protein BCA_1029 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BCA_1031 ENOG4108MJI response regulator BCA_1032 ENOG4105BZU Histidine kinase BCA_1033 ENOG4105BZU Histidine kinase BCA_1038 ENOG4105K8R UPF0145 protein BCA_1046 ENOG4107VRP DNA repair exonuclease BCA_1047 ENOG4106D4I domain protein BCA_1058 ENOG4108MUZ hydrolase BCA_1062 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BCA_1065 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BCA_1069 ENOG4105EMN RNA polymerase sigma factor BCA_1074 ENOG4105C57 major facilitator superfamily BCA_1075 ENOG4105C0R drug resistance transporter emrb qaca subfamily BCA_1077 ENOG4105EEM helicase BCA_1078 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BCA_1083 ENOG4105K59 histidine triad (HIT) protein BCA_1103 ENOG410905X membrane-flanked domain protein BCA_1104 ENOG4105CKV Membrane BCA_1114 ENOG410905X membrane-flanked domain protein BCA_1115 ENOG4105CKV Membrane BCA_1116 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BCA_1117 ENOG4105BZ4 penicillin-binding protein BCA_1120 ENOG4105C1Q protoporphyrinogen oxidase BCA_1126 ENOG4105NA0 Transcriptional regulator BCA_1129 ENOG4105ECB domain protein BCA_1135 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BCA_1137 ENOG4105D29 Helix-turn-helix type 11 domain protein BCA_1139 ENOG4106AXD BCA_1140 ENOG4108RQ5 Beta-lactamase domain-containing protein BCA_1141 ENOG4105DF9 Lipoate-protein, ligase BCA_1143 ENOG4105CEY Amp-dependent synthetase and ligase BCA_1154 ENOG4105ENX hydrolase BCA_1155 ENOG4107RN3 metallophosphoesterase BCA_1157 ENOG4107TVP HD domain protein BCA_1159 ENOG4108AEY RNA polymerase sigma factor BCA_1160 ENOG41086D8 Transcriptional regulator BCA_1162 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BCA_1166 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BCA_1171 ENOG4105ZU5 s-layer protein BCA_1172 ENOG4107QP3 malate synthase g BCA_1175 ENOG4105VEQ Cold shock protein BCA_1191 ENOG4105ERH Fumarylacetoacetate hydrolase BCA_1196 ENOG4105CAQ asparagine synthetase BCA_1197 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BCA_1198 ENOG4105CH6 catalase BCA_1199 ENOG4105BZU Histidine kinase BCA_1203 ENOG4105QNR S1 RNA binding domain protein BCA_1205 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BCA_1207 ENOG4107AYK membrAne BCA_1208 ENOG41073B9 BCA_1210 ENOG4108KP7 hydrolase BCA_1212 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BCA_1217 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BCA_1218 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BCA_1221 ENOG4105C31 Tryptophanyl-tRNA synthetase BCA_1224 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BCA_1225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BCA_1227 ENOG4108JQ7 (ABC) transporter BCA_1228 ENOG4105UQX Mate efflux family protein BCA_1233 ENOG4108ZCF integral membrane protein BCA_1235 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BCA_1237 ENOG4105DPN Oligoendopeptidase f BCA_1240 ENOG4108Z18 K06886 hemoglobin BCA_1241 ENOG4105MIX Adenylate cyclase BCA_1244 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BCA_1245 ENOG4105EMS pseudouridine synthase BCA_1249 ENOG4105K64 Glycosyl transferase, family 2 BCA_1253 ENOG4107TVC Glycosyl transferase, family 2 BCA_1257 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BCA_1258 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BCA_1260 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BCA_1275 ENOG4105CK7 Sodium proline symporter BCA_1277 ENOG4105CRQ synthase (Component I) BCA_1278 ENOG4105DDQ anthranilate synthase BCA_1296 ENOG4105C7S Dehydrogenase BCA_1298 ENOG4105VZ8 Transcriptional regulator BCA_1319 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BCA_1322 ENOG4108IUX (ABC) transporter BCA_1323 ENOG4105RHA ABC transporter, permease BCA_1326 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BCA_1328 ENOG4105DZ1 carboxypeptidase BCA_1329 ENOG4105VFR signal peptidase BCA_1336 ENOG4105C26 Dehydrogenase BCA_1338 ENOG4105F38 ABC transporter, permease BCA_1339 ENOG4105D38 putrescine abc transporter BCA_1340 ENOG4107RUE extracellular solute-binding protein family 1 BCA_1342 ENOG4105EYF MMPL domain protein BCA_1344 ENOG4108YBP pseudouridine synthase BCA_1346 ENOG4105K4I Scp-like extracellular BCA_1347 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BCA_1348 ENOG4105CQB FAD linked oxidase domain protein BCA_1351 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCA_1352 ENOG4105BZU Histidine kinase BCA_1353 ENOG4105JXH GntR family transcriptional regulator BCA_1357 ENOG4106A3R peptidase BCA_1359 ENOG4108QTI )-transporter BCA_1360 ENOG4107TS3 membrane protein, TerC BCA_1362 ENOG4105CZN Potassium uptake protein BCA_1363 ENOG410681C small acid-soluble spore protein BCA_1364 ENOG4108Z7G MaoC domain protein dehydratase BCA_1368 ENOG4105CHR reductase BCA_1370 ENOG4105MWK D-amino acid dehydrogenase, small subunit BCA_1375 ENOG4105C4Y ABC transporter BCA_1377 ENOG4107RCV ABC transporter, permease BCA_1381 ENOG4105E98 transcriptional regulator DeoR family BCA_1384 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BCA_1386 ENOG4105PXI polysaccharide deacetylase BCA_1388 ENOG4105BZU Histidine kinase BCA_1389 ENOG41090MY MarR family Transcriptional regulator BCA_1391 ENOG4106DF1 BCA_1393 ENOG4105BZU Histidine kinase BCA_1396 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BCA_1397 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BCA_1405 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BCA_1406 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BCA_1407 ENOG41079K6 HNH endonuclease BCA_1408 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BCA_1409 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BCA_1410 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BCA_1411 ENOG4105CZV ABC transporter BCA_1413 ENOG4105CJ1 ABC, transporter BCA_1421 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BCA_1422 ENOG4105EA8 2-Nitropropane dioxygenase BCA_1423 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BCA_1425 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BCA_1430 ENOG4105NQC Flavodoxin BCA_1444 ENOG4105CZN Potassium uptake protein BCA_1445 ENOG41063Y9 BCA_1446 ENOG4105KBJ sporulation protein ytfj BCA_1451 ENOG4105CM2 brancheD-chain amino acid aminotransferase BCA_1452 ENOG4105C7K acetolactate synthase BCA_1453 ENOG4108ZP8 Acetolactate synthase small subunit BCA_1468 ENOG4107RVV histidinol phosphate phosphatase, hisj family BCA_1471 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BCA_1472 ENOG4105E0M Sulfatase BCA_1475 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BCA_1480 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BCA_1481 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BCA_1483 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BCA_1484 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BCA_1485 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BCA_1486 ENOG4105C8J )-transporter BCA_1493 ENOG4105DFD Na H antiporter BCA_1497 ENOG4105ENE Histidine kinase BCA_1498 ENOG4105WH1 Two component transcriptional regulator luxr family BCA_1501 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BCA_1510 ENOG4105CJ3 phosphate transporter BCA_1511 ENOG4107GRR phosphate transport regulator BCA_1512 ENOG4105BZ4 penicillin-binding protein BCA_1515 ENOG4105BZU Histidine kinase BCA_1516 ENOG4105I3N Conserved Protein BCA_1519 ENOG4105BZU Histidine kinase BCA_1526 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BCA_1527 ENOG4105DZ1 carboxypeptidase BCA_1528 ENOG4108JIC nucleoside recognition domain protein BCA_1530 ENOG4105FE9 pseudouridine synthase BCA_1532 ENOG4107TWT Cytochrome c biogenesis protein BCA_1533 ENOG4105CRE cytochrome C BCA_1534 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCA_1535 ENOG4105BZU Histidine kinase BCA_1536 ENOG4108WBT adenosyltransferase BCA_1537 ENOG41063SB peptidase BCA_1541 ENOG4108SAX Membrane BCA_1544 ENOG4105C9U ATP-dependent DNA helicase RecQ BCA_1545 ENOG4105I7S Abortive infection protein BCA_1547 ENOG4107RGJ metallophosphoesterase BCA_1548 ENOG4107X2D transcriptional regulator, merr family BCA_1549 ENOG4108S6Z Negative regulator of genetic competence BCA_1554 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BCA_1555 ENOG4105HDK L-asparaginase BCA_1561 ENOG4105S2F BCA_1562 ENOG41065D1 BCA_1568 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BCA_1571 ENOG4105XXQ heptaprenyl diphosphate synthase component I BCA_1573 ENOG4105EAH synthase BCA_1577 ENOG4105CIH Imidazole acetol-phosphate transaminase BCA_1578 ENOG41068YB TPR repeat-containing protein BCA_1581 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BCA_1582 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BCA_1583 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BCA_1589 ENOG4108JYZ YitT family BCA_1590 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BCA_1593 ENOG4105FJR Lmbe family BCA_1594 ENOG4105CPK Glycosyl transferase (Group 1 BCA_1601 ENOG4105DVT helicase BCA_1602 ENOG4105YAC BCA_1606 ENOG4105CSM endonuclease III BCA_1608 ENOG4105BZ4 penicillin-binding protein BCA_1620 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BCA_1622 ENOG4105DVT helicase BCA_1623 ENOG4105CTD carboxy-peptidase BCA_1626 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BCA_1629 ENOG4105C2W permease BCA_1630 ENOG4105DHF Membrane BCA_1632 ENOG410890F Dynamin family BCA_1634 ENOG4108W0I acetyltransferase BCA_1636 ENOG4105KHC sulfurtransferase BCA_1642 ENOG4106032 Glutathionylspermidine synthase BCA_1649 ENOG4108SZE gCN5-related N-acetyltransferase BCA_1653 ENOG41081VK Ribonuclease BCA_1667 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BCA_1669 ENOG4107RWR Sodium hydrogen exchanger BCA_1670 ENOG4105CN5 Metallo-Beta-Lactamase BCA_1671 ENOG4108Z5V transcriptional regulator, merr family BCA_1673 ENOG4105H67 Protein of unknown function (DUF421) BCA_1675 ENOG41080C8 DUF218 domain BCA_1686 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BCA_1688 ENOG4107R0U MotA TolQ exbB proton channel BCA_1689 ENOG4105ER2 Ompa motb domain protein BCA_1690 ENOG4107YTP response regulator receiver protein BCA_1691 ENOG4105CBS Chea signal transduction histidine kinase BCA_1692 ENOG4105DD5 Flagellar motor switch protein BCA_1695 ENOG4105BZU Histidine kinase BCA_1699 ENOG4105E1Q flagellar hook-associated protein BCA_1700 ENOG4105DTJ flagellar hook-associated protein BCA_1701 ENOG4107TPX flagellar hook-associated BCA_1704 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BCA_1705 ENOG4108ZC9 flagellar basal-body rod protein flgc BCA_1706 ENOG41075Z6 flagellar hook-basal body complex protein fliE BCA_1707 ENOG4107U2N Flagellar M-ring protein BCA_1708 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BCA_1714 ENOG4105BZE flagellar hook protein, FlgE BCA_1717 ENOG4107R88 Chemotaxis protein (CheV) BCA_1719 ENOG4105I03 Flagellin BCA_1720 ENOG4105I03 Flagellin BCA_1721 ENOG4105E4C Lytic transglycosylase catalytic BCA_1723 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BCA_1724 ENOG4105DD5 Flagellar motor switch protein BCA_1726 ENOG4105CN7 Flagellar biosynthetic protein FliP BCA_1727 ENOG4105VS8 Flagellar biosynthetic protein fliq BCA_1729 ENOG4105D00 flagellar biosynthetic protein flhB BCA_1730 ENOG4105D7B Flagellar biosynthesis protein flha BCA_1731 ENOG4105FZW flagellar biosynthesis regulator FlhF BCA_1732 ENOG4105KTQ flagellar basal-body rod protein BCA_1733 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BCA_1738 ENOG41062JF Transcriptional regulator BCA_1742 ENOG4105KAC Antibiotic biosynthesis monooxygenase BCA_1747 ENOG4105DUM transcriptional regulator, lysR family BCA_1748 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BCA_1749 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BCA_1750 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BCA_1751 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BCA_1758 ENOG4105CVJ phosphoglycerate mutase BCA_1760 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BCA_1762 ENOG4105K56 Transcriptional regulator BCA_1764 ENOG4105CAQ asparagine synthetase BCA_1768 ENOG4105PGM cation diffusion facilitator family transporter BCA_1770 ENOG4105DRR Transcriptional regulator, GntR family BCA_1771 ENOG4108UZ3 Transporter BCA_1772 ENOG4105CKI cobalamin synthesis protein BCA_1774 ENOG4108PJD permease BCA_1777 ENOG4105DFD Na H antiporter BCA_1778 ENOG4105C9Q fumarate hydratase class II BCA_1783 ENOG4107QJQ Mate efflux family protein BCA_1784 ENOG4105EC3 peptidase S51, dipeptidase E BCA_1788 ENOG4107QIV Cytochrome c biogenesis protein BCA_1794 ENOG4106BRA Membrane BCA_1801 ENOG4105CJ1 ABC, transporter BCA_1805 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BCA_1807 ENOG4108IJ0 Aspartate ammonia-lyase BCA_1808 ENOG4105C6K Malic enzyme BCA_1823 ENOG4105FVX BCA_1831 ENOG4105CSR polyphosphate kinase 2 BCA_1832 ENOG4105U3E Transcriptional regulator BCA_1834 ENOG4105DXI Major Facilitator superfamily BCA_1836 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BCA_1838 ENOG4105EU0 Major facilitator Superfamily BCA_1839 ENOG4105C6T cysteine synthase BCA_1843 ENOG4105C8J )-transporter BCA_1845 ENOG4105X5K response regulator receiver protein BCA_1846 ENOG4105H67 Protein of unknown function (DUF421) BCA_1849 ENOG4106KE4 Dehydrogenase BCA_1853 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BCA_1854 ENOG4105CHR reductase BCA_1855 ENOG4105CM2 brancheD-chain amino acid aminotransferase BCA_1856 ENOG4105C7K acetolactate synthase BCA_1858 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BCA_1860 ENOG4105C7B Threonine dehydratase BCA_1864 ENOG4105C6X Major Facilitator BCA_1865 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BCA_1869 ENOG4105DY9 regulatoR BCA_1870 ENOG4105CYC Transferase BCA_1875 ENOG4108IBT Inherit from COG: transposase BCA_1878 ENOG4105VTR Integrase BCA_1890 ENOG4105YQ0 BCA_1891 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BCA_1942 ENOG41068WN BCA_1943 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BCA_1947 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BCA_1950 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BCA_1954 ENOG4105C0X amino acid BCA_1959 ENOG4107RHR regulatoR BCA_1961 ENOG4105D9N nucleoside BCA_1962 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BCA_1968 ENOG4107RAQ aminopeptidase BCA_1969 ENOG4107R16 Multicopper oxidase BCA_1978 ENOG4108T5E Copper resistance protein BCA_1979 ENOG4105KTB nuclear export factor GLE1 BCA_1981 ENOG4107RT3 EamA-like transporter family BCA_1982 ENOG4105GZI Transcriptional regulator BCA_1983 ENOG4108Z40 Transcriptional regulator BCA_1984 ENOG4107ZXU DSBA oxidoreductase BCA_1985 ENOG4108TVJ Nitroreductase BCA_1987 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BCA_1988 ENOG4106F5Q Membrane BCA_1989 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BCA_1992 ENOG4105CKI cobalamin synthesis protein BCA_1996 ENOG4108Z7G MaoC domain protein dehydratase BCA_1997 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BCA_1999 ENOG4105C0Z ABC transporter BCA_2000 ENOG4108IV0 ABC, transporter BCA_2001 ENOG4105C32 Amino acid ABC transporter (Permease) BCA_2003 ENOG4105EGI Transcriptional regulator BCA_2005 ENOG4105MDS 4-oxalocrotonate tautomerase BCA_2009 ENOG4105C4M (Ubiquinol oxidase) subunit I BCA_2010 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BCA_2011 ENOG4108JJ9 ABC, transporter BCA_2012 ENOG4108JJ8 (ABC) transporter BCA_2015 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BCA_2020 ENOG4105BZ1 (ABC) transporter BCA_2021 ENOG4105EFI regulatoR BCA_2022 ENOG4105BZU Histidine kinase BCA_2024 ENOG4108VQJ O-methyltransferase BCA_2025 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BCA_2026 ENOG4108ZJ4 polysaccharide deacetylase BCA_2030 ENOG4105D6E homoserine dehydrogenase BCA_2035 ENOG4108KGH TRANSCRIPTIONal BCA_2037 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BCA_2038 ENOG4105BZU Histidine kinase BCA_2039 ENOG4107VMI polysaccharide deacetylase BCA_2041 ENOG4105KT7 mgtC SapB transporter BCA_2042 ENOG4105VRR gCN5-related N-acetyltransferase BCA_2044 ENOG4105DUU IucA IucC family protein BCA_2045 ENOG4105CEY Amp-dependent synthetase and ligase BCA_2048 ENOG4108WBH protein TIM barrel BCA_2049 ENOG4105YWU small acid-soluble spore protein BCA_2051 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BCA_2052 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BCA_2074 ENOG4105EFC phage portal protein HK97 family BCA_2081 ENOG4105KRN Transcriptional regulator, abrb family BCA_2083 ENOG4105YVS arsR family transcriptional regulator BCA_2084 ENOG4107SET aldo keto reductase BCA_2085 ENOG4107XZQ multidrug resistance protein BCA_2090 ENOG4105C8Q Methyl-accepting chemotaxis BCA_2093 ENOG4108K88 Membrane BCA_2094 ENOG4108WPJ Ferritin-like domain BCA_2097 ENOG4105DEN Luciferase family BCA_2100 ENOG4105VMI -acetyltransferase BCA_2101 ENOG4107QM2 Aldo Keto reductase BCA_2102 ENOG4105CKI cobalamin synthesis protein BCA_2106 ENOG4108IBT Inherit from COG: transposase BCA_2107 ENOG4105DSE periplasmic solute binding protein BCA_2109 ENOG4105K4T epimerase BCA_2111 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BCA_2116 ENOG4105CVJ phosphoglycerate mutase BCA_2120 ENOG4107T5V SNARE associated Golgi BCA_2123 ENOG4108PJD permease BCA_2125 ENOG4108S4H thioesterase Superfamily protein BCA_2126 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BCA_2130 ENOG4105SXS Protein of unknown function (DUF456) BCA_2131 ENOG4105C37 (CBS) domain BCA_2135 ENOG4108Z7R Chaperone CsaA BCA_2138 ENOG4108ZRV stage ii sporulation protein p BCA_2140 ENOG4108VXD carboxy-peptidase BCA_2142 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BCA_2146 ENOG4105EFA 4-hydroxyphenylacetate BCA_2148 ENOG4105U1N riboflavin BCA_2151 ENOG4105KME endoribonuclease L-psp BCA_2157 ENOG41069HH 4-oxalocrotonate tautomerase BCA_2159 ENOG4108X4Q Hydrolase BCA_2161 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BCA_2162 ENOG4107RBS Methyltransferase BCA_2165 ENOG41087PP glycosyltransferase MGT family BCA_2166 ENOG4108JYZ YitT family BCA_2167 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BCA_2173 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BCA_2189 ENOG4105KBJ sporulation protein ytfj BCA_2194 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BCA_2198 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BCA_2199 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BCA_2201 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BCA_2202 ENOG4105EMN RNA polymerase sigma factor BCA_2205 ENOG4105CNW domain protein BCA_2207 ENOG4108V06 Glutathione peroxidase BCA_2210 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BCA_2214 ENOG4108IUE nitrate reductase beta subunit BCA_2215 ENOG4105R3A Nitrate reductase BCA_2217 ENOG4107V6Q Cyclic nucleotide-binding domain BCA_2218 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BCA_2219 ENOG4105D06 uba thif-type nad fad binding protein BCA_2220 ENOG4105CVM Molybdenum cofactor synthesis domain protein BCA_2221 ENOG4108ZAF Molybdopterin BCA_2226 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BCA_2227 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BCA_2228 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BCA_2229 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BCA_2230 ENOG4108IFG nitrite reductase, (NAD(P)H) BCA_2231 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BCA_2238 ENOG4105MCT stage V sporulation protein S BCA_2246 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BCA_2253 ENOG4105C5H ABC transporter BCA_2256 ENOG4108UUM single-stranded DNA-binding protein BCA_2262 ENOG4107YX5 Pfam:DUF548 BCA_2270 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BCA_2271 ENOG4105C5S asparaginyl-tRNA synthetase BCA_2275 ENOG4105EC2 ftsk spoIIIe BCA_2294 ENOG4105BZW Glycerate kinase BCA_2295 ENOG4107QPK )-transporter BCA_2296 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCA_2297 ENOG41062D9 Histidine kinase BCA_2300 ENOG4105C8J )-transporter BCA_2304 ENOG4107XGZ Hydrolase BCA_2305 ENOG4105CY2 Citrate transporter BCA_2306 ENOG4105C0A alcohol dehydrogenase BCA_2309 ENOG4105KD7 acetyltransferase BCA_2310 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BCA_2315 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BCA_2319 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BCA_2323 ENOG4107RVG penicillin-binding protein BCA_2325 ENOG4105E9Q Acyl-transferase BCA_2326 ENOG4108UT2 hemolysin iii BCA_2328 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BCA_2330 ENOG4108RCR degv family BCA_2331 ENOG4105E8R UPF0173 metal-dependent hydrolase BCA_2332 ENOG4108KF3 Electron transport protein SCO1 SenC BCA_2333 ENOG4107Y70 Heat shock protein BCA_2334 ENOG4105CAQ asparagine synthetase BCA_2338 ENOG4108MES Periplasmic binding protein BCA_2339 ENOG4105F0I Aminotransferase BCA_2346 ENOG4105D8X mechanosensitive ion channel BCA_2347 ENOG4105BZU Histidine kinase BCA_2348 ENOG4105WH1 Two component transcriptional regulator luxr family BCA_2349 ENOG4106KNT transcriptional regulator BCA_2355 ENOG4105CMG Carbohydrate kinase BCA_2361 ENOG4108IJ8 ABC transporter BCA_2362 ENOG4105E90 ABC transporter BCA_2369 ENOG4105C37 (CBS) domain BCA_2375 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BCA_2378 ENOG4107S4Y M20 DapE family protein YgeY BCA_2379 ENOG4108TSC N-acetyltransferase BCA_2380 ENOG4108JUB Transcriptional regulator BCA_2381 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BCA_2389 ENOG4108N23 SpoOM-related protein BCA_2391 ENOG410841Q phosphoesterase PA-phosphatase related protein BCA_2392 ENOG4105SZ6 Thioredoxin BCA_2403 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BCA_2413 ENOG4105BZ4 penicillin-binding protein BCA_2414 ENOG4105CZM Major Facilitator BCA_2415 ENOG4105CZM Major Facilitator BCA_2416 ENOG4105W8X HesB YadR YfhF-family protein BCA_2418 ENOG4105DXD 2-methylcitrate dehydratase BCA_2419 ENOG4105CR4 methylisocitrate lyase BCA_2421 ENOG4105C1G acyl-Coa dehydrogenase BCA_2422 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BCA_2424 ENOG4105N14 lysine exporter protein LysE YggA BCA_2425 ENOG4105E39 Enoyl-CoA hydratase BCA_2428 ENOG4107RFY SbcCD D subunit BCA_2429 ENOG4105EYH Exonuclease BCA_2434 ENOG4105FCD Major Facilitator BCA_2435 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BCA_2436 ENOG4105E4F Isochorismate synthase BCA_2437 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BCA_2438 ENOG4105WQI isochorismatase BCA_2439 ENOG4105CEY Amp-dependent synthetase and ligase BCA_2440 ENOG4105WQT MbtH domain protein BCA_2441 ENOG4105C0R drug resistance transporter emrb qaca subfamily BCA_2444 ENOG4105K70 DNA-binding protein BCA_2448 ENOG4105BZG amino acid carrier protein BCA_2453 ENOG4105FE9 pseudouridine synthase BCA_2455 ENOG4105C22 threonyL-tRNA synthetase BCA_2457 ENOG4105C19 ABC transporter BCA_2459 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BCA_2464 ENOG4108D32 Methyltransferase BCA_2471 ENOG41081I9 integral membrane protein BCA_2473 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BCA_2475 ENOG4105EYF MMPL domain protein BCA_2480 ENOG4105WCN acetyltransferase BCA_2486 ENOG4105C1Q protoporphyrinogen oxidase BCA_2488 ENOG41089UC methyltransferase, type 11 BCA_2489 ENOG41068WN BCA_2491 ENOG4105VEQ Cold shock protein BCA_2496 ENOG4107V2S Transcriptional regulator BCA_2497 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BCA_2500 ENOG4105DND Transcriptional regulator BCA_2501 ENOG4108RPX mosc domain containing protein BCA_2505 ENOG4105BZ1 (ABC) transporter BCA_2506 ENOG4105BZ1 (ABC) transporter BCA_2509 ENOG4108JCI Transcriptional regulator BCA_2515 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BCA_2518 ENOG4108KPJ rna polymerase sigma factor BCA_2523 ENOG4105F32 YngK protein BCA_2529 ENOG4105RD7 BadF BadG BcrA BcrD BCA_2531 ENOG4107STF Involved in phosphonate degradation (By similarity) BCA_2539 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BCA_2542 ENOG4105C1J atp-dependent rna helicase BCA_2546 ENOG4108RZE Tetr family transcriptional regulator BCA_2550 ENOG41088CC tellurite resistance protein tehB BCA_2554 ENOG4105VTR Integrase BCA_2570 ENOG4107RA9 decarboxylase BCA_2572 ENOG41090HR transcriptional regulator BCA_2580 ENOG4105CIN aminoacyl-histidine dipeptidase BCA_2583 ENOG4105EQK -acetyltransferase BCA_2586 ENOG4107RVG penicillin-binding protein BCA_2589 ENOG4107RF6 penicillin-binding protein BCA_2590 ENOG4107RF6 penicillin-binding protein BCA_2593 ENOG4105ETE Transcriptional regulator (LacI family BCA_2594 ENOG4105IE8 Alpha-ketoglutarate permease BCA_2596 ENOG4105CK5 oxidoreductase BCA_2601 ENOG4105D2N Aldolase BCA_2602 ENOG4105DH8 myo-inositol catabolism BCA_2607 ENOG4105CGH 5'-nucleotidase BCA_2609 ENOG4107JM4 Tetratricopeptide repeat BCA_2610 ENOG4105VZ8 Transcriptional regulator BCA_2612 ENOG4108VXD carboxy-peptidase BCA_2615 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity BCA_2616 ENOG41067SE Tetr family transcriptional regulator BCA_2617 ENOG4105C5H ABC transporter BCA_2619 ENOG4105BZU Histidine kinase BCA_2624 ENOG4105CEP NADH dehydrogenase BCA_2625 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BCA_2631 ENOG4105C1G acyl-Coa dehydrogenase BCA_2632 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BCA_2633 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BCA_2634 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BCA_2635 ENOG4105E39 Enoyl-CoA hydratase BCA_2636 ENOG4107QX3 carboxylase BCA_2637 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BCA_2640 ENOG4105DBI uridine monophosphokinase BCA_2647 ENOG4105T9C HD domain BCA_2649 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BCA_2657 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BCA_2657 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BCA_2662 ENOG4107Y80 Major Facilitator superfamily BCA_2664 ENOG41089UC methyltransferase, type 11 BCA_2681 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BCA_2683 ENOG4105DK7 lysyl-tRNA synthetase BCA_2702 ENOG4105ETU transcriptional activator (TenA BCA_2725 ENOG410667J hydrolase BCA_2726 ENOG4105BZU Histidine kinase BCA_2727 ENOG4107RF6 penicillin-binding protein BCA_2735 ENOG4108HGU Histidine kinase BCA_2737 ENOG4105RHY Pfam:UPF0157 BCA_2738 ENOG4105CB2 alcohol dehydrogenase BCA_2739 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BCA_2740 ENOG4105CJN penicillin-binding protein BCA_2741 ENOG4108IG5 Transcriptional regulator BCA_2742 ENOG4105CHR reductase BCA_2744 ENOG4105FQP Beta-lactamase BCA_2751 ENOG4108V4B ThiJ pfpI BCA_2755 ENOG4107Y80 Major Facilitator superfamily BCA_2758 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BCA_2763 ENOG4107Y9U Membrane BCA_2771 ENOG4105FCD Major Facilitator BCA_2772 ENOG4105E09 nadh pyrophosphatase BCA_2773 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BCA_2774 ENOG4108Z4K mutator MutT protein BCA_2779 ENOG4107TB6 phosphoglycerate mutase BCA_2781 ENOG4108XI2 Domain of unknown function (DUF1963) BCA_2786 ENOG4108NRW Phospholipase, patatin family BCA_2787 ENOG4105KWG Pfam:DUF1696 BCA_2795 ENOG4105PKS Excinuclease abc c subunit domain protein BCA_2803 ENOG4107VFR oxidoreductase BCA_2806 ENOG4105PAD Hydrolase BCA_2811 ENOG4108IUM Glycogen debranching enzyme BCA_2816 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BCA_2817 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BCA_2819 ENOG4105FDR Membrane BCA_2830 ENOG4105MSI germination protein ypeb BCA_2838 ENOG4107Z3H Transcriptional regulator, TetR family BCA_2844 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BCA_2847 ENOG4108MK9 spermidine N(1)-acetyltransferase BCA_2848 ENOG4105E98 transcriptional regulator DeoR family BCA_2852 ENOG41062ES Transcriptional regulator BCA_2856 ENOG4107QKR Dehydrogenase BCA_2858 ENOG4107RUY (E1 component), alpha subunit BCA_2860 ENOG4105E1F short-chain dehydrogenase reductase BCA_2861 ENOG4105RHY Pfam:UPF0157 BCA_2862 ENOG4105DBI uridine monophosphokinase BCA_2864 ENOG4105M6F mutator MutT protein BCA_2869 ENOG4107SQ8 Glycine betaine BCA_2870 ENOG4108IJ7 Glycine betaine BCA_2875 ENOG4105E66 phosphoriboisomerase A BCA_2876 ENOG41082BV acetyltransferase BCA_2877 ENOG4108M1A Chitin-binding protein BCA_2881 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BCA_2882 ENOG4105MSB protein, conserved in bacteria BCA_2883 ENOG4107YB6 acetyltransferase, (GNAT) family BCA_2884 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BCA_2890 ENOG4108Z7F N-acetyltransferase BCA_2894 ENOG4105EEM helicase BCA_2898 ENOG4105C9U ATP-dependent DNA helicase RecQ BCA_2908 ENOG4108M1A Chitin-binding protein BCA_2911 ENOG4105BZG amino acid carrier protein BCA_2912 ENOG4105C26 Dehydrogenase BCA_2913 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BCA_2914 ENOG4105CTU Proline racemase BCA_2915 ENOG4105CTU Proline racemase BCA_2916 ENOG41080HI glycine oxidase BCA_2918 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BCA_2924 ENOG4107T5V SNARE associated Golgi BCA_2927 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BCA_2928 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BCA_2931 ENOG4105DTQ mandelate racemase muconate lactonizing BCA_2940 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BCA_2941 ENOG4105BZU Histidine kinase BCA_2942 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCA_2948 ENOG4105DPN Oligoendopeptidase f BCA_2949 ENOG4105DVH amino acid BCA_2951 ENOG4105EPR degv family BCA_2961 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BCA_2962 ENOG4106K7D Major facilitator family transporter BCA_2967 ENOG4107BMA Transglycosylase associated protein BCA_2970 ENOG41089UC methyltransferase, type 11 BCA_2977 ENOG4105CHM Aminotransferase BCA_2980 ENOG4108ZMI UPF0477 protein BCA_2983 ENOG4105DVE abc transporter atp-binding protein BCA_2991 ENOG4105C02 permease BCA_2993 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BCA_2994 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BCA_2995 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BCA_2998 ENOG4105E09 nadh pyrophosphatase BCA_3002 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BCA_3018 ENOG4108ZCF integral membrane protein BCA_3019 ENOG4105E0M Sulfatase BCA_3020 ENOG4105C5H ABC transporter BCA_3023 ENOG41082JN Transcriptional regulator BCA_3027 ENOG4105CIH Imidazole acetol-phosphate transaminase BCA_3029 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BCA_3037 ENOG41069ER domain protein BCA_3039 ENOG4105CY2 Citrate transporter BCA_3040 ENOG4105E39 Enoyl-CoA hydratase BCA_3041 ENOG4105J5T Amp-dependent synthetase and ligase BCA_3042 ENOG4108JUB Transcriptional regulator BCA_3045 ENOG4105D4B ABC, transporter BCA_3047 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BCA_3050 ENOG4105DKT Transcriptional regulator BCA_3051 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BCA_3053 ENOG41061GT Aldolase BCA_3058 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BCA_3065 ENOG4105II7 pyrroline-5-carboxylate reductase BCA_3067 ENOG4107258 Transcriptional regulator BCA_3069 ENOG4105E0Y RtcB Protein BCA_3070 ENOG4105ECK Fatty Acid Desaturase BCA_3071 ENOG4105G6Z alkaline phosphatase BCA_3073 ENOG4105VMP Transcriptional regulator BCA_3076 ENOG41090T1 Membrane BCA_3078 ENOG4108WCX response regulator BCA_3080 ENOG41068WN BCA_3085 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BCA_3092 ENOG4105CKK Glycosyl transferase, family 2 BCA_3094 ENOG4105C8Y Acetylornithine aminotransferase BCA_3095 ENOG4105CH6 catalase BCA_3103 ENOG4108TVJ Nitroreductase BCA_3104 ENOG4105FS7 Transcriptional regulator BCA_3112 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BCA_3114 ENOG4105CMR udp-glucose 4-epimerase BCA_3115 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BCA_3121 ENOG4108XET gCN5-related N-acetyltransferase BCA_3138 ENOG410635A Membrane BCA_3141 ENOG4108IQI permease BCA_3143 ENOG4105F1N DNA alkylation repair BCA_3150 ENOG4107RF6 penicillin-binding protein BCA_3151 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BCA_3158 ENOG4105P4J Allophanate hydrolase, subunit 1 BCA_3159 ENOG4107258 Transcriptional regulator BCA_3161 ENOG4106N3A copper homeostasis protein cutc BCA_3162 ENOG4108ZRV stage ii sporulation protein p BCA_3163 ENOG4108ZHR arsR family transcriptional regulator BCA_3165 ENOG4105FDT acyl-CoA dehydrogenase BCA_3170 ENOG4105DWD nucleoside recognition domain protein BCA_3175 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BCA_3189 ENOG4105E2A Dehydrogenase BCA_3192 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BCA_3195 ENOG4105CGH 5'-nucleotidase BCA_3196 ENOG41061CK Antibiotic biosynthesis monooxygenase BCA_3206 ENOG4106A3M Cytochrome p-450 BCA_3207 ENOG4105YA8 Transcriptional regulator BCA_3211 ENOG4108606 TspO/MBR family BCA_3212 ENOG4105CVP deoxyribo-dipyrimidine photolyase BCA_3215 ENOG4108TWJ NADH dehydrogenase subunit 5 BCA_3216 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BCA_3219 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BCA_3220 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BCA_3221 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BCA_3223 ENOG4105C19 ABC transporter BCA_3226 ENOG4108NEV two component transcriptional regulator, LytTR family BCA_3227 ENOG4105DSE periplasmic solute binding protein BCA_3228 ENOG4105CC5 ABC transporter BCA_3229 ENOG4105DIK (ABC) transporter BCA_3234 ENOG4105D6J arsenicaL-resistance protein BCA_3235 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BCA_3236 ENOG41085FC arsR family transcriptional regulator BCA_3239 ENOG4105F7F Chaperone BCA_3251 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BCA_3252 ENOG4105C0R drug resistance transporter emrb qaca subfamily BCA_3254 ENOG4105IIP Membrane BCA_3257 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCA_3258 ENOG41062D9 Histidine kinase BCA_3263 ENOG4105K6H D-cysteine desulfhydrase BCA_3268 ENOG4108NNI Beta-lactamase domain-containing protein BCA_3269 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BCA_3271 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BCA_3274 ENOG4105C88 aminopeptidase BCA_3277 ENOG4105JQZ Methyltransferase BCA_3282 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BCA_3285 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BCA_3288 ENOG4105BZU Histidine kinase BCA_3291 ENOG4108U05 Transcriptional regulator BCA_3292 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BCA_3294 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BCA_3295 ENOG4105DJB Major Facilitator Superfamily BCA_3296 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BCA_3297 ENOG4107QR9 Iron-sulfur cluster binding protein BCA_3299 ENOG4106P55 Transcriptional regulator BCA_3305 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BCA_3309 ENOG4105CEP NADH dehydrogenase BCA_3311 ENOG4105D4Y metalloprotease BCA_3312 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BCA_3319 ENOG4106ANW SMI1_KNR4 BCA_3325 ENOG4105TRI Hydrolase BCA_3334 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BCA_3339 ENOG4105C44 Serine transporter BCA_3340 ENOG4105EJQ L-serine dehydratase BCA_3343 ENOG4108JPW Aminotransferase BCA_3346 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BCA_3348 ENOG4105DVH amino acid BCA_3352 ENOG4108JQ1 Dehydrogenase BCA_3356 ENOG4108AEY RNA polymerase sigma factor BCA_3359 ENOG41082W1 Cupin 2, conserved barrel domain protein BCA_3360 ENOG410874W AraC family transcriptional regulator BCA_3363 ENOG4108IBT Inherit from COG: transposase BCA_3366 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BCA_3368 ENOG4108IG5 Transcriptional regulator BCA_3377 ENOG4108ISG Major Facilitator BCA_3379 ENOG4107MII Sugar-specific transcriptional regulator TrmB BCA_3380 ENOG4105CZM Major Facilitator BCA_3384 ENOG4105DA5 (ABC) transporter BCA_3385 ENOG41069JR BCA_3387 ENOG4105RXJ BCA_3388 ENOG4105KPY Small multidrug resistance protein BCA_3389 ENOG4105KBX Transcriptional regulator, TetR family BCA_3390 ENOG4107AUC BCA_3393 ENOG4105CRW Short chain fatty acid transporter BCA_3394 ENOG4105DYS nad(p)h dehydrogenase (quinone) BCA_3401 ENOG4108JJB ABC transporter BCA_3402 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BCA_3407 ENOG4108K8S endonuclease I BCA_3408 ENOG4108Z66 YbaK ebsC protein BCA_3410 ENOG4105WH1 Two component transcriptional regulator luxr family BCA_3414 ENOG4105KVH Transcriptional regulator BCA_3415 ENOG4108RCM Nitroreductase BCA_3419 ENOG4108PSK reductase BCA_3421 ENOG4105CJ1 ABC, transporter BCA_3427 ENOG4105D7V transposase BCA_3436 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BCA_3437 ENOG4105DKQ ROK family BCA_3438 ENOG4106UW1 Major Facilitator superfamily BCA_3439 ENOG4108UW5 maltose o-acetyltransferase BCA_3441 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BCA_3443 ENOG4105C31 Tryptophanyl-tRNA synthetase BCA_3450 ENOG4105DMQ Methyltransferase BCA_3452 ENOG4105EV4 Multidrug resistance protein mdtH BCA_3458 ENOG4105C37 (CBS) domain BCA_3461 ENOG4105DDN Pentapeptide repeat-containing protein BCA_3463 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BCA_3464 ENOG4105CMG Carbohydrate kinase BCA_3465 ENOG4105C6Z Gluconate BCA_3466 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BCA_3469 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BCA_3470 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BCA_3476 ENOG4105C44 Serine transporter BCA_3482 ENOG4105KVH Transcriptional regulator BCA_3483 ENOG4108TZY GntR Family Transcriptional Regulator BCA_3484 ENOG4105D9R oxidoreductase BCA_3491 ENOG4105JAB phenazine biosynthesis protein, phzf family BCA_3493 ENOG4105CHR reductase BCA_3495 ENOG4105KNA -acetyltransferase BCA_3497 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BCA_3498 ENOG4105KVH Transcriptional regulator BCA_3502 ENOG4108ZJ4 polysaccharide deacetylase BCA_3511 ENOG4105KAF membrAne BCA_3522 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BCA_3525 ENOG4107YXZ hydrolase, family 25 BCA_3532 ENOG4105H3G oxidoreductase BCA_3541 ENOG4105K7K Transcriptional regulator BCA_3542 ENOG4105CIS alcohol dehydrogenase BCA_3549 ENOG4108TN2 lmbE family BCA_3551 ENOG4107R3E Citrate transporter BCA_3554 ENOG4108MES Periplasmic binding protein BCA_3555 ENOG4105EHG Permease protein BCA_3556 ENOG4105DQ5 transport system permease protein BCA_3557 ENOG4105NX3 Membrane BCA_3558 ENOG4107ZY0 Phenazine biosynthesis-like protein BCA_3562 ENOG4107V2S Transcriptional regulator BCA_3566 ENOG4105C98 muts2 protein BCA_3570 ENOG4105E5K Alpha-amylase BCA_3571 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BCA_3572 ENOG4105DPN Oligoendopeptidase f BCA_3573 ENOG4108A04 Beta-lactamase BCA_3579 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BCA_3585 ENOG41082BM Transcriptional regulator, arsr family BCA_3586 ENOG4105CIS alcohol dehydrogenase BCA_3591 ENOG4105RHY Pfam:UPF0157 BCA_3593 ENOG4105C09 Bile acid BCA_3594 ENOG4105CQB FAD linked oxidase domain protein BCA_3598 ENOG4108UT6 Transferase hexapeptide repeat containing protein BCA_3600 ENOG4105K64 Glycosyl transferase, family 2 BCA_3601 ENOG4105E39 Enoyl-CoA hydratase BCA_3603 ENOG4105KT7 mgtC SapB transporter BCA_3606 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BCA_3607 ENOG41073R8 VanW family BCA_3609 ENOG4108R1P BCA_3613 ENOG4105VEQ Cold shock protein BCA_3617 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BCA_3628 ENOG4105DR5 peptidase BCA_3629 ENOG41065S2 pneumococcal vaccine antigen BCA_3631 ENOG4107YXZ hydrolase, family 25 BCA_3641 ENOG410904N short-chain dehydrogenase reductase BCA_3643 ENOG4106IQC argininosuccinate lyase BCA_3646 ENOG4108IA2 Sodium pantothenate symporter BCA_3648 ENOG4105C26 Dehydrogenase BCA_3649 ENOG4105CHR reductase BCA_3651 ENOG4105EWU Squalene--hopene cyclase BCA_3653 ENOG4105FR1 rard protein BCA_3654 ENOG410696E Membrane BCA_3657 ENOG4105D1F ATP-binding protein BCA_3659 ENOG4108ZAF Molybdopterin BCA_3660 ENOG4105CVM Molybdenum cofactor synthesis domain protein BCA_3661 ENOG4105D06 uba thif-type nad fad binding protein BCA_3662 ENOG4105TMB Formate nitrite transporter BCA_3664 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BCA_3665 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BCA_3667 ENOG4108JB9 formate dehydrogenase BCA_3668 ENOG4105E1K spore germination protein BCA_3680 ENOG4107QJT sodium dicarboxylate symporter BCA_3681 ENOG4108KGH TRANSCRIPTIONal BCA_3683 ENOG4105EMN RNA polymerase sigma factor BCA_3686 ENOG4105CIG ABC transporter BCA_3688 ENOG4105D9R oxidoreductase BCA_3691 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BCA_3692 ENOG4105K4P CoA-binding domain protein BCA_3693 ENOG4105C0H protease BCA_3694 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCA_3696 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BCA_3697 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BCA_3698 ENOG4105W8X HesB YadR YfhF-family protein BCA_3704 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BCA_3705 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BCA_3708 ENOG4108JJA ABC, transporter BCA_3709 ENOG4108I0Z Aconitate hydratase BCA_3715 ENOG4105E5W Transporter BCA_3717 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BCA_3721 ENOG4107F3J Amp-dependent synthetase and ligase BCA_3722 ENOG4107ZYJ bioY protein BCA_3723 ENOG4105CEY Amp-dependent synthetase and ligase BCA_3734 ENOG4107AYK membrAne BCA_3736 ENOG4105BZU Histidine kinase BCA_3737 ENOG4105FBA Phospholipase Carboxylesterase BCA_3738 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BCA_3739 ENOG4105CK7 Sodium proline symporter BCA_3740 ENOG4105CBC glutamate synthase BCA_3741 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BCA_3742 ENOG4108VJ1 Transcriptional regulator (CarD family BCA_3743 ENOG4108903 Formimidoylglutamase BCA_3748 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BCA_3761 ENOG4107QIV Cytochrome c biogenesis protein BCA_3763 ENOG4105CH2 amidohydrolase BCA_3765 ENOG4105CJ1 ABC, transporter BCA_3767 ENOG4107RSM transcriptional regulator BCA_3769 ENOG41067MG lrgb family BCA_3774 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BCA_3777 ENOG4105BZ1 (ABC) transporter BCA_3778 ENOG4105BZ1 (ABC) transporter BCA_3786 ENOG4105CGH 5'-nucleotidase BCA_3788 ENOG4108SVB resolvase BCA_3792 ENOG4105K7K Transcriptional regulator BCA_3794 ENOG4105C5F glutamine synthetase BCA_3795 ENOG4105KV4 Transcriptional regulator BCA_3796 ENOG4105CXI aluminum resistance protein BCA_3797 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BCA_3798 ENOG4105EN6 Membrane BCA_3800 ENOG4106F1P AAA ATPase, central domain protein BCA_3806 ENOG41069ER domain protein BCA_3807 ENOG4105DM4 PTS System BCA_3808 ENOG4105DE4 1-phosphofructokinase BCA_3809 ENOG4105E98 transcriptional regulator DeoR family BCA_3810 ENOG4107QW4 alcohol dehydrogenase BCA_3811 ENOG4108SJC Membrane BCA_3814 ENOG4105C85 amino acid BCA_3818 ENOG4105TMB Formate nitrite transporter BCA_3819 ENOG4105K70 DNA-binding protein BCA_3823 ENOG4105C59 p-type ATPase BCA_3824 ENOG410681U heavy metal transport detoxification protein BCA_3825 ENOG4105VPX protein, conserved in bacteria BCA_3827 ENOG4105NIV Esterase BCA_3828 ENOG4105E0A ABC, transporter BCA_3833 ENOG4105CGK Exodeoxyribonuclease III BCA_3835 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BCA_3836 ENOG4105D03 DNA-3-methyladenine glycosylase II BCA_3843 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BCA_3844 ENOG4105BZU Histidine kinase BCA_3853 ENOG41067MG lrgb family BCA_3859 ENOG4105F0V Cell wall hydrolase BCA_3861 ENOG4105E0M Sulfatase BCA_3862 ENOG410890F Dynamin family BCA_3864 ENOG4107QHE Choloylglycine hydrolase BCA_3870 ENOG4105DQU oxidoreductase, subunit beta BCA_3871 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BCA_3872 ENOG4108IGT Dipeptidase BCA_3873 ENOG4105MCT stage V sporulation protein S BCA_3874 ENOG4105D48 metallophosphoesterase BCA_3878 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BCA_3881 ENOG4105XZV Protein of unknown function (DUF3243) BCA_3882 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BCA_3886 ENOG4105UIB (ABC) transporter BCA_3887 ENOG4108JQ9 ABC transporter BCA_3888 ENOG4105DIH basic membrane BCA_3889 ENOG4105FDP GntR family transcriptional regulator BCA_3891 ENOG4107QZI cell division protein FtsK BCA_3893 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BCA_3895 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BCA_3897 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BCA_3898 ENOG4108S0H Dipicolinic acid synthetase, b subunit BCA_3899 ENOG4105E35 Dipicolinate synthase subunit A BCA_3901 ENOG4105C1V Peptidase, M16 BCA_3905 ENOG4105DTN riboflavin biosynthesis protein ribF BCA_3908 ENOG4105W7A Protein of unknown function (DUF503) BCA_3910 ENOG4105VHM ribosomal protein BCA_3911 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BCA_3912 ENOG4105CHV Transcription elongation factor NusA BCA_3914 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BCA_3916 ENOG4105EKQ RNA-directed DNA polymerase BCA_3917 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BCA_3919 ENOG4105DZP Membrane-associated zinc metalloprotease BCA_3921 ENOG4105KNE Phosphatidate cytidylyltransferase BCA_3930 ENOG4108HE4 integrase family BCA_3932 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BCA_3933 ENOG4105C79 DNA protecting protein DprA BCA_3934 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BCA_3937 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BCA_3943 ENOG4105VB6 UPF0109 protein BCA_3947 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BCA_3948 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BCA_3951 ENOG4105CHR reductase BCA_3952 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BCA_3955 ENOG4105CB5 ATP-dependent DNA helicase recG BCA_3956 ENOG4105DP4 dak2 domain fusion protein ylov BCA_3957 ENOG4108ZAA Alkaline-shock protein BCA_3959 ENOG4105FJ0 thiamine BCA_3960 ENOG4105DJV ribulose-phosphate 3-epimerase BCA_3961 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BCA_3962 ENOG4105D9P serine threonine protein kinase BCA_3963 ENOG4108ZF3 Phosphatase BCA_3965 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BCA_3967 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BCA_3968 ENOG4105C25 Primosomal protein n' BCA_3969 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BCA_3973 ENOG4105DSJ YicC domain protein BCA_3975 ENOG4105F23 Fibronectin-binding protein BCA_3976 ENOG4105DC7 peptidase M24 BCA_3988 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BCA_3996 ENOG4105C34 Pseudouridine synthase BCA_4001 ENOG4105DBK s4 domain protein BCA_4002 ENOG41067XK integral membrane protein BCA_4004 ENOG4105DFA alanine racemase domain protein BCA_4005 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BCA_4006 ENOG4105WR5 sporulation protein, YlmC YmxH family BCA_4008 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BCA_4010 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BCA_4011 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BCA_4012 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BCA_4013 ENOG4105D4A Cell wall formation (By similarity) BCA_4014 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BCA_4015 ENOG4105CNI cell division protein FtsW BCA_4018 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BCA_4019 ENOG4105CJN penicillin-binding protein BCA_4020 ENOG4105CJN penicillin-binding protein BCA_4021 ENOG41068DC Essential cell division protein (By similarity) BCA_4028 ENOG4105KNH Nucleic acid-binding protein BCA_4030 ENOG41063PX domain protein BCA_4031 ENOG4105D78 K07001 NTE family protein BCA_4033 ENOG4105H20 Sporulation integral membrane protein YlbJ BCA_4034 ENOG4106H78 methyltransferase BCA_4039 ENOG4107TB6 phosphoglycerate mutase BCA_4042 ENOG4106UY4 Inherit from COG: Scp-like extracellular BCA_4052 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BCA_4053 ENOG4105CNI cell division protein FtsW BCA_4056 ENOG4108IAB Phoh family BCA_4060 ENOG4105QA2 BCA_4061 ENOG4105CI3 gtp-binding protein typa BCA_4063 ENOG4105ECY inositol monophosphatase BCA_4067 ENOG4105CXN decarboxylase BCA_4076 ENOG4105CPP Dehydrogenase, E1 component BCA_4079 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BCA_4080 ENOG4108X4Q Hydrolase BCA_4082 ENOG4105CN5 Metallo-Beta-Lactamase BCA_4083 ENOG4107ZYR domain protein BCA_4090 ENOG4108XRC Protein of unknown function (DUF458) BCA_4092 ENOG4107IN1 Protein of unknown function (DUF1797) BCA_4096 ENOG4105EPM Diguanylate phosphodiesterase BCA_4097 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BCA_4101 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BCA_4103 ENOG4105UIN BCA_4116 ENOG4108HGU Histidine kinase BCA_4118 ENOG4105CHM Aminotransferase BCA_4119 ENOG4105FKQ transcriptional regulator BCA_4121 ENOG4105EG2 ABC transporter, permease BCA_4123 ENOG4107FKK extracellular solute-binding protein family 1 BCA_4125 ENOG4105CG3 alpha amylase, catalytic region BCA_4134 ENOG4105CHU acetyl-coa acetyltransferase BCA_4140 ENOG4105K7K Transcriptional regulator BCA_4141 ENOG4105DTD Dehydrogenase BCA_4146 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BCA_4155 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BCA_4156 ENOG4106TD9 Diguanylate cyclase BCA_4160 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BCA_4163 ENOG4105CID antiterminator BCA_4165 ENOG4105FDP GntR family transcriptional regulator BCA_4167 ENOG4105CE4 GlcNAc 6-P deacetylase BCA_4173 ENOG4107ZE5 PPIases accelerate the folding of proteins BCA_4174 ENOG4105PTM secreted protein BCA_4175 ENOG4105J7I hydrolase BCA_4177 ENOG4105G6R Stage v sporulation protein ae BCA_4179 ENOG4105CZ3 stage V sporulation protein ad BCA_4180 ENOG41090VF Stage v sporulation protein ac BCA_4184 ENOG4105C8J )-transporter BCA_4185 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BCA_4187 ENOG41082AN stage II sporulation protein BCA_4188 ENOG4105DZ1 carboxypeptidase BCA_4189 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BCA_4190 ENOG4105DVE abc transporter atp-binding protein BCA_4196 ENOG4105D7N magnesium and cobalt transport protein CorA BCA_4201 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BCA_4203 ENOG4105I3K Ferric uptake regulator, Fur family BCA_4204 ENOG4105MZ9 stage II sporulation protein m BCA_4208 ENOG4105CPC Aldo Keto reductase BCA_4210 ENOG4105RHY Pfam:UPF0157 BCA_4214 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BCA_4216 ENOG4105ETE Transcriptional regulator (LacI family BCA_4217 ENOG4108YM7 Gcn5-related n-acetyltransferase BCA_4222 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BCA_4223 ENOG4108R6K riboflavin synthase, subunit alpha BCA_4228 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BCA_4229 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BCA_4232 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BCA_4235 ENOG4105DFD Na H antiporter BCA_4236 ENOG4105CGH 5'-nucleotidase BCA_4244 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BCA_4247 ENOG4108IXY short-chain dehydrogenase reductase BCA_4248 ENOG41069FQ Metallo-beta-lactamase superfamily BCA_4249 ENOG4105II7 pyrroline-5-carboxylate reductase BCA_4250 ENOG4105EJQ L-serine dehydratase BCA_4255 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BCA_4256 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BCA_4257 ENOG4105D9U N-acetyltransferase BCA_4259 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BCA_4260 ENOG4108QEG Membrane BCA_4261 ENOG4105CDA abc transporter atp-binding protein BCA_4262 ENOG4105E5Q amino acid AbC transporter BCA_4263 ENOG4108HW3 (ABC) transporter BCA_4266 ENOG4105G7B Protein of unknown function (DUF2992) BCA_4267 ENOG4105E09 nadh pyrophosphatase BCA_4269 ENOG4105C7S Dehydrogenase BCA_4270 ENOG4105CPP Dehydrogenase, E1 component BCA_4274 ENOG4107RDP Dehydrogenase BCA_4276 ENOG4108JUB Transcriptional regulator BCA_4278 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BCA_4281 ENOG4107QQR Sporulation BCA_4282 ENOG4105S1Z Stage IV sporulation protein B BCA_4283 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BCA_4285 ENOG4105DX0 Hemolysin A BCA_4287 ENOG4105CTB Polyprenyl synthetase BCA_4292 ENOG4108ZSR alkaline shock protein BCA_4293 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BCA_4297 ENOG410644B Stage III sporulation protein af BCA_4299 ENOG4105KQ4 Stage iii sporulation protein ad BCA_4300 ENOG4108CQH stage III sporulation protein AC BCA_4301 ENOG4105KR5 Stage iii sporulation protein BCA_4302 ENOG4105CD2 stage iii sporulation protein aa BCA_4306 ENOG4105DC7 peptidase M24 BCA_4309 ENOG4105CBJ Metal-dependent enzyme BCA_4310 ENOG4107YBY Hydrolase BCA_4314 ENOG4105K7K Transcriptional regulator BCA_4318 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BCA_4319 ENOG4105WZW rhodanese family BCA_4323 ENOG41080TC multidrug resistance protein BCA_4330 ENOG4105CJ1 ABC, transporter BCA_4331 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BCA_4337 ENOG4105C0D helicase BCA_4363 ENOG4105C3R Methionine synthase BCA_4367 ENOG4105C28 cystathionine BCA_4368 ENOG4105C28 cystathionine BCA_4372 ENOG4105C5X domain protein BCA_4374 ENOG4105DKQ ROK family BCA_4376 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BCA_4379 ENOG4108UTW Plays a role in the regulation of phosphate uptake BCA_4380 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BCA_4381 ENOG4105E2Z phosphate ABC transporter (Permease BCA_4382 ENOG4105C8U phosphate abc transporter BCA_4383 ENOG4105PWN phosphate abc transporter BCA_4384 ENOG4107RF6 penicillin-binding protein BCA_4386 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BCA_4391 ENOG4105N80 Ferric uptake regulator, Fur family BCA_4393 ENOG4105FDK ABC transporter BCA_4394 ENOG4108JYZ YitT family BCA_4395 ENOG41069ZM Protein of unknown function (DUF2624) BCA_4400 ENOG4105EGD dinuclear metal center protein, YbgI family BCA_4403 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BCA_4404 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BCA_4411 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BCA_4412 ENOG4105KG3 cytidine deaminase BCA_4413 ENOG4107YR5 Diacylglycerol kinase BCA_4415 ENOG4105CTJ Metal Dependent Phosphohydrolase BCA_4416 ENOG4105C9A Phoh family BCA_4418 ENOG41068P3 sporulation protein YqfC BCA_4419 ENOG4105KTH gatB Yqey BCA_4421 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BCA_4422 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BCA_4426 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BCA_4428 ENOG4105CSA Coproporphyrinogen iii oxidase BCA_4429 ENOG4105KVH Transcriptional regulator BCA_4434 ENOG4105TQK DNA polymerase iii, delta' subunit BCA_4436 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BCA_4437 ENOG4108UK2 deaminase BCA_4438 ENOG4105KQC Competence protein BCA_4440 ENOG4105DXX methyltransferase BCA_4442 ENOG4108WF2 Metal Dependent Phosphohydrolase BCA_4444 ENOG410812S Rna-binding protein BCA_4446 ENOG4105CQW ribosome biogenesis GTPase YqeH BCA_4447 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BCA_4450 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BCA_4454 ENOG4108TVJ Nitroreductase BCA_4458 ENOG4105G6Z alkaline phosphatase BCA_4461 ENOG4108MUZ hydrolase BCA_4468 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BCA_4470 ENOG4105MIR Phenylalanine 4-monooxygenase BCA_4472 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BCA_4480 ENOG4105S6R Iron-hydroxamate transporter permease subunit BCA_4481 ENOG4108V5C ABC transporter BCA_4483 ENOG4108EKI Dehydrogenase BCA_4484 ENOG4105C28 cystathionine BCA_4490 ENOG4107XRG penicillin-binding protein BCA_4493 ENOG4105CFP Peptidase U32 BCA_4494 ENOG4105XYU peptidase (U32 family) BCA_4495 ENOG4108VQJ O-methyltransferase BCA_4496 ENOG4105HHA aminodeoxychorismate lyase BCA_4502 ENOG4105C02 permease BCA_4505 ENOG41060CR BCA_4506 ENOG4105C7H Helicase, RecD TraA family BCA_4509 ENOG4105C3J Cysteine desulfurase BCA_4511 ENOG4105D1H recombination factor protein RarA BCA_4512 ENOG4108VCI transcription factor, rsfa family BCA_4513 ENOG4105CUZ uba thif-type nad fad binding protein BCA_4515 ENOG4105CUT histidyl-tRNA synthetase BCA_4518 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BCA_4520 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BCA_4521 ENOG41076HS cation diffusion facilitator family transporter BCA_4522 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BCA_4524 ENOG4105CKP Polysaccharide Biosynthesis Protein BCA_4525 ENOG4108QG2 Membrane BCA_4527 ENOG4105VIE preprotein translocase, subunit YajC BCA_4530 ENOG41061AI Protein of unknown function (DUF2905) BCA_4533 ENOG4108HUF Transporter BCA_4535 ENOG4108IPJ Membrane BCA_4536 ENOG4108IPJ Membrane BCA_4537 ENOG41082BM Transcriptional regulator, arsr family BCA_4542 ENOG4108IYU L-aspartate oxidase BCA_4545 ENOG4108RPX mosc domain containing protein BCA_4546 ENOG4105CQC Prephenate dehydratase BCA_4550 ENOG4105EWM Histidine kinase BCA_4555 ENOG4105X36 (ribosomal) protein BCA_4558 ENOG4105C03 ribonuclease BCA_4561 ENOG4107QMS site-determining protein BCA_4564 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BCA_4565 ENOG4105DFF Rod shape-determining protein mreb BCA_4569 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BCA_4570 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BCA_4572 ENOG41068KH stage VI sporulation protein D BCA_4574 ENOG4105D52 delta-aminolevulinic acid dehydratase BCA_4579 ENOG4105K56 Transcriptional regulator BCA_4583 ENOG4108IUQ atp-dependent protease BCA_4589 ENOG4108QCI YvbH-like oligomerisation region BCA_4594 ENOG4105M59 Phosphodiesterase, mj0936 family BCA_4595 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BCA_4597 ENOG4108XJQ germination protein BCA_4599 ENOG4108PCX Major Facilitator BCA_4602 ENOG4105KBX Transcriptional regulator, TetR family BCA_4605 ENOG4105PFC Transcriptional regulator BCA_4607 ENOG4105DZC cytosine deaminase BCA_4608 ENOG41067S9 phage shock protein C, PspC BCA_4609 ENOG4108JCI Transcriptional regulator BCA_4611 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BCA_4613 ENOG4108Z40 Transcriptional regulator BCA_4614 ENOG4105RHA ABC transporter, permease BCA_4615 ENOG4108IUX (ABC) transporter BCA_4616 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BCA_4617 ENOG4105ER2 Ompa motb domain protein BCA_4618 ENOG4105E14 MotA TolQ exbB proton channel BCA_4620 ENOG4108VXD carboxy-peptidase BCA_4622 ENOG4105E33 succinate dehydrogenase BCA_4624 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BCA_4627 ENOG4105K63 Thioredoxin BCA_4628 ENOG4105C10 Electron transfer flavoprotein BCA_4629 ENOG4105BZJ Electron transfer flavoprotein BCA_4630 ENOG41060WC Enoyl-CoA hydratase BCA_4631 ENOG4107Z3H Transcriptional regulator, TetR family BCA_4632 ENOG4105CEY Amp-dependent synthetase and ligase BCA_4635 ENOG4105J76 Periplasmic binding protein BCA_4636 ENOG4105S6R Iron-hydroxamate transporter permease subunit BCA_4643 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BCA_4646 ENOG4105DR4 Methyltransferase BCA_4649 ENOG4105KFN sortase, SrtB family BCA_4650 ENOG4105E0A ABC, transporter BCA_4653 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BCA_4654 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BCA_4656 ENOG4105FE9 pseudouridine synthase BCA_4658 ENOG4105DCG PHP domain protein BCA_4665 ENOG4105C5S asparaginyl-tRNA synthetase BCA_4666 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BCA_4668 ENOG4108RWN rrna methyltransferase BCA_4677 ENOG4105C0R drug resistance transporter emrb qaca subfamily BCA_4678 ENOG4105CW7 secretion protein, HlyD family BCA_4679 ENOG4108JGH Tetr family transcriptional regulator BCA_4680 ENOG4105CN9 Peptidase m42 family protein BCA_4684 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BCA_4686 ENOG4105C22 threonyL-tRNA synthetase BCA_4687 ENOG4108TDW sporulation protein YtxC BCA_4691 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BCA_4693 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BCA_4694 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BCA_4696 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BCA_4697 ENOG4105C2M dna polymerase I BCA_4698 ENOG4105BZU Histidine kinase BCA_4699 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BCA_4703 ENOG4108HMX isocitrate dehydrogenase (NADP) BCA_4704 ENOG4105BZN citrate synthase BCA_4706 ENOG4108REF Sporulation integral membrane protein ytvi BCA_4707 ENOG4105FS0 cytoplasmic membrane protein BCA_4712 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BCA_4713 ENOG4105C6K Malic enzyme BCA_4714 ENOG4105C0B DNA polymerase III (alpha subunit) BCA_4716 ENOG4105VV2 BCA_4718 ENOG4105SFS phosphoesterase RecJ domain protein BCA_4726 ENOG4105DC7 peptidase M24 BCA_4735 ENOG41082W1 Cupin 2, conserved barrel domain protein BCA_4737 ENOG4105VZ8 Transcriptional regulator BCA_4741 ENOG4107YZX Universal stress protein BCA_4749 ENOG4108JYZ YitT family BCA_4752 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BCA_4754 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BCA_4755 ENOG4105KBJ sporulation protein ytfj BCA_4758 ENOG4105EFZ amidohydrolase BCA_4760 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BCA_4765 ENOG4106KR7 LysR family Transcriptional regulator BCA_4767 ENOG4105U5Y Transcriptional regulator BCA_4769 ENOG4105C28 cystathionine BCA_4778 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BCA_4781 ENOG4105F1V Acetoin utilization protein BCA_4782 ENOG4105W87 Cbs domain BCA_4783 ENOG4105DGU Histone deacetylase BCA_4786 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BCA_4788 ENOG4107SNB ankyrin repeat protein YahD BCA_4789 ENOG4105EP9 oxidoreductase BCA_4795 ENOG4105ETE Transcriptional regulator (LacI family BCA_4799 ENOG4105C88 aminopeptidase BCA_4808 ENOG4105K7K Transcriptional regulator BCA_4814 ENOG4108VDD TRNA binding domain protein BCA_4820 ENOG4105C8F Beta-lactamase domain protein BCA_4823 ENOG4108V15 phosphotransferase enzyme family BCA_4824 ENOG4108IUM Glycogen debranching enzyme BCA_4826 ENOG4107QSE Dipeptidase BCA_4827 ENOG4105YW5 deoR family transcriptional regulator BCA_4830 ENOG4105CBX hi0933 family BCA_4838 ENOG4108VJ1 Transcriptional regulator (CarD family BCA_4839 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BCA_4843 ENOG4108ZAF Molybdopterin BCA_4844 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BCA_4845 ENOG4105CVM Molybdenum cofactor synthesis domain protein BCA_4847 ENOG4105D06 uba thif-type nad fad binding protein BCA_4848 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BCA_4852 ENOG41085GJ domain protein BCA_4854 ENOG4105DWV Homoserine O-trans-acetylase BCA_4858 ENOG4108B31 Spore germination protein BCA_4865 ENOG410605W Major Facilitator BCA_4866 ENOG4107S91 Sodium hydrogen exchanger BCA_4867 ENOG4105NCW Trka-c domain protein BCA_4870 ENOG4105C19 ABC transporter BCA_4874 ENOG4105N5T Radical SAM Protein BCA_4876 ENOG4105CIG ABC transporter BCA_4882 ENOG4105E8V Alpha Beta Hydrolase Fold protein BCA_4883 ENOG4108Z0R Transferase BCA_4884 ENOG4105YVM Phosphoesterase, PA-phosphatase related BCA_4885 ENOG4105BZF Glycosyl transferase (Group 1 BCA_4887 ENOG4108RIR Molybdenum cofactor biosynthesis protein BCA_4901 ENOG4107XGZ Hydrolase BCA_4902 ENOG4105E98 transcriptional regulator DeoR family BCA_4904 ENOG4105BZU Histidine kinase BCA_4905 ENOG4105BZU Histidine kinase BCA_4906 ENOG4107S9D Alpha beta hydrolase BCA_4907 ENOG4107T7U Sulfatase BCA_4910 ENOG4105D2X ABC transporter substrate-binding protein BCA_4912 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BCA_4915 ENOG4107XGZ Hydrolase BCA_4923 ENOG4108V2W Carbonate dehydratase BCA_4925 ENOG4105C4M (Ubiquinol oxidase) subunit I BCA_4926 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BCA_4936 ENOG41087YS Phage shock protein A BCA_4942 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BCA_4951 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BCA_4952 ENOG4105BZU Histidine kinase BCA_4953 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCA_4958 ENOG4108UGV hypoxanthine phosphoribosyltransferase BCA_4959 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BCA_4961 ENOG4105D7V transposase BCA_4964 ENOG4107ZTW SNARE associated Golgi BCA_4969 ENOG4105C19 ABC transporter BCA_4970 ENOG41086D8 Transcriptional regulator BCA_4978 ENOG4105C6Z Gluconate BCA_4979 ENOG4105FDP GntR family transcriptional regulator BCA_4983 ENOG41069H0 dihydroorotase EC 3.5.2.3 BCA_4987 ENOG4105DTQ mandelate racemase muconate lactonizing BCA_4989 ENOG4108IPT Naphthoate synthase BCA_4990 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BCA_4992 ENOG4105E4F Isochorismate synthase BCA_4993 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BCA_4995 ENOG4105VEQ Cold shock protein BCA_5004 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BCA_5005 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BCA_5032 ENOG4105KT7 mgtC SapB transporter BCA_5034 ENOG4107PBV potassium channel BCA_5036 ENOG4105WG9 Conserved Protein BCA_5038 ENOG4105CHM Aminotransferase BCA_5039 ENOG4108ZB6 transcriptional regulator AsnC family BCA_5040 ENOG4105C5I Dehydrogenase BCA_5041 ENOG4108MUZ hydrolase BCA_5044 ENOG4105C87 Aminotransferase class I and II BCA_5047 ENOG4105Y38 Kinase-associated protein B BCA_5049 ENOG4107R3E Citrate transporter BCA_5052 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BCA_5053 ENOG4105KA0 thioesterase Superfamily protein BCA_5056 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BCA_5060 ENOG41069ER domain protein BCA_5063 ENOG4105CEP NADH dehydrogenase BCA_5069 ENOG4105EWC Purine nucleoside phosphorylase BCA_5071 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BCA_5076 ENOG4108JJA ABC, transporter BCA_5077 ENOG4105C4B ABC transporter, permease BCA_5078 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BCA_5083 ENOG41083MR nifu domain-containing protein BCA_5086 ENOG4108W5N phosphatidylglycerophosphatase a BCA_5089 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BCA_5090 ENOG4105DYS nad(p)h dehydrogenase (quinone) BCA_5091 ENOG4105D4U had-superfamily hydrolase, subfamily iia BCA_5094 ENOG4105CBT Fructose-1,6-bisphosphatase BCA_5097 ENOG4105MMD transcriptional regulator BCA_5098 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BCA_5099 ENOG4107TXC Transcriptional regulator BCA_5100 ENOG41090T1 Membrane BCA_5105 ENOG4105FAA peptidase M23 BCA_5107 ENOG4105KZD Domain of unknown function (DUF1805) BCA_5112 ENOG4105DIW FeS assembly protein SUFB BCA_5113 ENOG4108UNV SUF system FeS assembly protein, NifU family BCA_5114 ENOG4105C9B Cysteine desulfurase BCA_5115 ENOG4105JRK feS assembly protein SufD BCA_5116 ENOG4105C3K feS assembly ATPase SufC BCA_5117 ENOG4105D01 (LipO)protein BCA_5118 ENOG4105D01 (LipO)protein BCA_5119 ENOG4108UMI ABC transporter, permease BCA_5127 ENOG41080E8 Transcriptional regulator, Spx MgsR family BCA_5136 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BCA_5146 ENOG4108W8B Beta-lactamase domain protein BCA_5147 ENOG4108IUW ABC transporter BCA_5152 ENOG4105C1G acyl-Coa dehydrogenase BCA_5153 ENOG4105CHU acetyl-coa acetyltransferase BCA_5156 ENOG4105DZ1 carboxypeptidase BCA_5160 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BCA_5164 ENOG4108SUT Major Facilitator Superfamily BCA_5165 ENOG4107R7I amino acid BCA_5168 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BCA_5170 ENOG4107AYK membrAne BCA_5178 ENOG4107ZTW SNARE associated Golgi BCA_5180 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BCA_5181 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCA_5182 ENOG4105BZU Histidine kinase BCA_5186 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BCA_5187 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BCA_5188 ENOG4105VG1 fes assembly suf system protein BCA_5189 ENOG4105D4Y metalloprotease BCA_5193 ENOG4107S91 Sodium hydrogen exchanger BCA_5194 ENOG4105NCW Trka-c domain protein BCA_5196 ENOG4108RMU ferritin dps family protein BCA_5199 ENOG4108URH decarboxylase BCA_5203 ENOG4105D9N nucleoside BCA_5204 ENOG4105D9N nucleoside BCA_5208 ENOG4108RYK Nad-dependent epimerase dehydratase BCA_5211 ENOG4105CV8 reductase BCA_5212 ENOG4105F27 Major Facilitator BCA_5213 ENOG4105KVH Transcriptional regulator BCA_5216 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BCA_5217 ENOG4105D4A Cell wall formation (By similarity) BCA_5219 ENOG4105C8Q Methyl-accepting chemotaxis BCA_5221 ENOG4105WMR Protein CrcB homolog BCA_5226 ENOG4105C5H ABC transporter BCA_5227 ENOG4108MK9 spermidine N(1)-acetyltransferase BCA_5228 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BCA_5231 ENOG4108IPW abc transporter atp-binding protein BCA_5232 ENOG4105CM4 permease protein BCA_5240 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BCA_5242 ENOG4105XZU Preprotein translocase, subunit SecG BCA_5243 ENOG41067MG lrgb family BCA_5253 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BCA_5263 ENOG4108C33 Resolvase BCA_5271 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BCA_5274 ENOG41090VF Stage v sporulation protein ac BCA_5275 ENOG4105CZ3 stage V sporulation protein ad BCA_5278 ENOG4105H67 Protein of unknown function (DUF421) BCA_5279 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BCA_5280 ENOG4105KRI phosphocarrier protein (HPr BCA_5282 ENOG4105CHW UPF0052 protein BCA_5284 ENOG4108Z4K mutator MutT protein BCA_5286 ENOG4105C3M thioredoxin reductase BCA_5288 ENOG4108S4C acetyltransferase BCA_5292 ENOG41086DT Membrane protein of unknown function BCA_5294 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BCA_5295 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BCA_5298 ENOG4107TXC Transcriptional regulator BCA_5303 ENOG4105HMI Membrane BCA_5304 ENOG4105DUM transcriptional regulator, lysR family BCA_5306 ENOG4108WS4 fmn reductase BCA_5307 ENOG4105C5H ABC transporter BCA_5309 ENOG4105BZ1 (ABC) transporter BCA_5311 ENOG4105CN1 protease BCA_5312 ENOG4105CRP Part of the ABC transporter FtsEX involved in BCA_5313 ENOG4105CAK Cell division ATP-binding protein ftsE BCA_5319 ENOG4105MS2 ribosomal subunit Interface protein BCA_5321 ENOG4105VEQ Cold shock protein BCA_5322 ENOG41081UC Inherit from COG: Competence protein BCA_5325 ENOG4105KVH Transcriptional regulator BCA_5327 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BCA_5328 ENOG4108KGH TRANSCRIPTIONal BCA_5329 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BCA_5330 ENOG4105C6Y Udp-glucose 6-dehydrogenase BCA_5331 ENOG4105ESV Glycosyl transferase, family 4 BCA_5333 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BCA_5337 ENOG4105F8D glycoside hydrolase family 4 BCA_5338 ENOG4105VCP PTS System BCA_5339 ENOG4105CK1 PTS System BCA_5341 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BCA_5346 ENOG4105VCP PTS System BCA_5348 ENOG4105VZJ PTS System BCA_5351 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BCA_5356 ENOG4105ECB domain protein BCA_5357 ENOG4107RSM transcriptional regulator BCA_5365 ENOG4105DAA L-lactate BCA_5366 ENOG4105D7V transposase BCA_5368 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BCA_5370 ENOG4105E0M Sulfatase BCA_5375 ENOG4107R8N Glycosyl transferase, family 2 BCA_5377 ENOG4105C94 Transporter BCA_5378 ENOG41069ER domain protein BCA_5383 ENOG4105KBK Zinc finger, swim domain protein BCA_5384 ENOG4105C0D helicase BCA_5390 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BCA_5393 ENOG4107RBB ABC transporter, permease BCA_5394 ENOG4105C19 ABC transporter BCA_5398 ENOG4105CXY transporter BCA_5402 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCA_5403 ENOG4105DG6 mannose-6-phosphate isomerase BCA_5404 ENOG4105DM4 PTS System BCA_5406 ENOG4105CMR udp-glucose 4-epimerase BCA_5408 ENOG4108KGH TRANSCRIPTIONal BCA_5409 ENOG4105DG6 mannose-6-phosphate isomerase BCA_5410 ENOG4105CJT Mannose-1-phosphate guanylyltransferase BCA_5411 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BCA_5412 ENOG4108TJN glycosyl transferase group 1 BCA_5413 ENOG4105C6Y Udp-glucose 6-dehydrogenase BCA_5417 ENOG4105D3Q Sugar transferase BCA_5418 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BCA_5419 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BCA_5420 ENOG4107YJ4 chain length determinant protein BCA_5421 ENOG4105HTX biosynthesis protein BCA_5422 ENOG4107YJ4 chain length determinant protein BCA_5425 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BCA_5427 ENOG4105FRN stage II sporulation protein BCA_5430 ENOG4105DY9 regulatoR BCA_5434 ENOG4106778 Protein of unknown function (DUF1146) BCA_5435 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BCA_5436 ENOG4105C8S subunit m BCA_5437 ENOG4105D65 subunit l BCA_5442 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BCA_5443 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BCA_5445 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BCA_5446 ENOG4105BZU Histidine kinase BCA_5456 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BCA_5457 ENOG41062M3 atp synthase BCA_5465 ENOG4108YZG isomerase BCA_5468 ENOG4108VGI doxx family BCA_5469 ENOG4107XC4 flavin reductase domain protein, FMN-binding BCA_5474 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BCA_5476 ENOG4108ZXQ stage ii sporulation protein r BCA_5477 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BCA_5478 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BCA_5481 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BCA_5482 ENOG4105CBT Fructose-1,6-bisphosphatase BCA_5483 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BCA_5491 ENOG4105C1G acyl-Coa dehydrogenase BCA_5492 ENOG4105C1G acyl-Coa dehydrogenase BCA_5493 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BCA_5495 ENOG4105DF6 Fe-S oxidoreductase BCA_5498 ENOG4105BZU Histidine kinase BCA_5503 ENOG4105BZU Histidine kinase BCA_5504 ENOG4105KCT ABC transporter BCA_5505 ENOG4108M15 ABC transporter BCA_5506 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BCA_5508 ENOG4105IIU Aminopeptidase BCA_5512 ENOG4105EMN RNA polymerase sigma factor BCA_5514 ENOG410684U Domain of unknown function (DUF1934) BCA_5519 ENOG4105CYW agmatinase BCA_5521 ENOG4105DXB Major Facilitator superfamily BCA_5522 ENOG4107SWG transcriptional regulator MERR family BCA_5524 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BCA_5525 ENOG4105BZ4 penicillin-binding protein BCA_5526 ENOG4108XFG YwhD family BCA_5527 ENOG4108Z4T Peptidase M50 BCA_5528 ENOG41069HH 4-oxalocrotonate tautomerase BCA_5529 ENOG4105DCI Phosphohydrolase BCA_5530 ENOG4108MES Periplasmic binding protein BCA_5531 ENOG4105E0A ABC, transporter BCA_5532 ENOG4105EHG Permease protein BCA_5533 ENOG4105DQ5 transport system permease protein BCA_5535 ENOG4108VCI transcription factor, rsfa family BCA_5538 ENOG4108IJ2 phosphate acetyltransferase BCA_5542 ENOG4108VKI Cell wall hydrolase BCA_5546 ENOG4107SVH Potassium channel protein BCA_5548 ENOG410667J hydrolase BCA_5549 ENOG4105VCH membrane BCA_5551 ENOG4108TU7 Inherit from COG: (ABC) transporter BCA_5552 ENOG4105CJ1 ABC, transporter BCA_5553 ENOG41090WU lipolytic protein G-D-S-L family BCA_5556 ENOG4105D6E homoserine dehydrogenase BCA_5561 ENOG4108Y4K DNA-binding transcriptional activator BCA_5563 ENOG4105WH1 Two component transcriptional regulator luxr family BCA_5564 ENOG4105BZU Histidine kinase BCA_5565 ENOG4105DWF phosphomethylpyrimidine kinase BCA_5566 ENOG4105BZU Histidine kinase BCA_5567 ENOG4105VCD cytoplasmic protein BCA_5568 ENOG4105D22 carbon starvation protein BCA_5569 ENOG4105DY9 regulatoR BCA_5570 ENOG41079KZ Major Facilitator Superfamily BCA_5575 ENOG4105EN6 Membrane BCA_5576 ENOG4106YBV Methyl-accepting chemotaxis BCA_5578 ENOG4108S4H thioesterase Superfamily protein BCA_5580 ENOG4105JEU Glycosyl transferase, family 2 BCA_5581 ENOG4105C5H ABC transporter BCA_5585 ENOG4105CKK Glycosyl transferase, family 2 BCA_5586 ENOG41067SE Tetr family transcriptional regulator BCA_5588 ENOG4105E0X reductase BCA_5589 ENOG4106F5Q Membrane BCA_5592 ENOG4105DY9 regulatoR BCA_5593 ENOG4108HRK Histidine kinase BCA_5595 ENOG4107RGD Major Facilitator superfamily BCA_5598 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BCA_5600 ENOG4105IW1 AmiS UreI transporter BCA_5602 ENOG4105CMR udp-glucose 4-epimerase BCA_5603 ENOG4108UT2 hemolysin iii BCA_5605 ENOG4105C1J atp-dependent rna helicase BCA_5608 ENOG4105DPN Oligoendopeptidase f BCA_5612 ENOG4105C0H protease BCA_5613 ENOG4105Q2H domain protein BCA_5616 ENOG4105BZU Histidine kinase BCA_5617 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCA_5623 ENOG4105CDU Replicative dna helicase BCA_5625 ENOG4105BZR domain protein BCA_5626 ENOG4108XMW Membrane BCA_5628 ENOG4108UUM single-stranded DNA-binding protein BCA_5630 ENOG4105C3G gtp-binding protein BCA_5631 ENOG4105VDK protein, conserved in bacteria BCA_5632 ENOG4105D8X mechanosensitive ion channel BCA_5633 ENOG4108ZDA Sporulation protein YyaC BCA_5634 ENOG4105FA0 parb-like partition protein BCA_5635 ENOG4107QJE Chromosome Partitioning Protein BCA_5641 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BCA_A0045 ENOG41082BM Transcriptional regulator, arsr family BCA_A0046 ENOG4107QZI cell division protein FtsK BCA_A0098 ENOG4105DHF Membrane BCA_A0101 ENOG4105D7V transposase BCA_A0104 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BCA_A0107 ENOG4106AKK s-layer domain-containing protein BCA_A0108 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BCA_A0113 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BCA_A0114 ENOG4105C6Y Udp-glucose 6-dehydrogenase BCA_A0117 ENOG4105DQ6 Transposase BCA_A0129 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BCA_A0143 ENOG4108K8S endonuclease I BCA_A0162 ENOG4105KRN Transcriptional regulator, abrb family BCA_A0164 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BCA_A0174 ENOG4108IBT Inherit from COG: transposase BCA_A0176 ENOG4105DQ6 Transposase BCA_A0177 ENOG4105DQ6 Transposase BCA_A0180 ENOG4105DQ6 Transposase BCA_A0181 ENOG4105DQ6 Transposase BCA_A0184 ENOG4108MEK Metal-binding protein YodA BCA_A0187 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) BCA_A0188 ENOG4107QKA exodeoxyribonuclease V beta BCA_A0196 ENOG4108IBT Inherit from COG: transposase BCA_A0199 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)