locus-tag class description AS54_1 ENOG4105EN6 Membrane AS54_1005 ENOG4105CSH Transporter AS54_1007 ENOG4108MRH transcriptional regulatory protein AS54_1015 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 AS54_1022 ENOG4105CDU Replicative dna helicase AS54_1027 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS54_1037 ENOG4107P5I polyketide synthase AS54_1038 ENOG4108IG5 Transcriptional regulator AS54_1041 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AS54_1047 ENOG4105CMT Dihydroxyacetone kinase AS54_1049 ENOG4105CMT Dihydroxyacetone kinase AS54_105 ENOG4105CXN decarboxylase AS54_1050 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AS54_1051 ENOG410847I Transcriptional regulator, BadM Rrf2 family AS54_1054 ENOG410780I phosphoprotein phosphatase activity AS54_1056 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AS54_1069 ENOG4105WN5 stage II sporulation protein AS54_107 ENOG4105FA2 dna polymerase iii AS54_1071 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS54_1073 ENOG4108MJI response regulator AS54_1074 ENOG4105BZU Histidine kinase AS54_1075 ENOG4105BZU Histidine kinase AS54_108 ENOG4105MA4 psp1 domain protein AS54_1080 ENOG4105K8R UPF0145 protein AS54_1088 ENOG4107VRP DNA repair exonuclease AS54_1089 ENOG4106D4I domain protein AS54_1099 ENOG4108MUZ hydrolase AS54_11 ENOG4105CKK Glycosyl transferase, family 2 AS54_110 ENOG41060K3 Methyltransferase AS54_1103 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AS54_1106 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AS54_1111 ENOG4105EMN RNA polymerase sigma factor AS54_1116 ENOG4105C57 major facilitator superfamily AS54_1117 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS54_1119 ENOG4105EEM helicase AS54_112 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AS54_1120 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AS54_1125 ENOG4105K59 histidine triad (HIT) protein AS54_113 ENOG4105KRN Transcriptional regulator, abrb family AS54_1143 ENOG410905X membrane-flanked domain protein AS54_1144 ENOG4105CKV Membrane AS54_1149 ENOG4108TVJ Nitroreductase AS54_115 ENOG4105F8V Hydrolase, tatD family AS54_1155 ENOG410905X membrane-flanked domain protein AS54_1156 ENOG4105CKV Membrane AS54_1157 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AS54_1158 ENOG4105BZ4 penicillin-binding protein AS54_116 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AS54_1161 ENOG4105C1Q protoporphyrinogen oxidase AS54_1167 ENOG4105NA0 Transcriptional regulator AS54_1170 ENOG4105ECB domain protein AS54_1176 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) AS54_1178 ENOG4105D29 Helix-turn-helix type 11 domain protein AS54_118 ENOG4105XFA sporulation peptidase YabG AS54_1180 ENOG4106AXD AS54_1181 ENOG4108RQ5 Beta-lactamase domain-containing protein AS54_1182 ENOG4105DF9 Lipoate-protein, ligase AS54_1184 ENOG4105CEY Amp-dependent synthetase and ligase AS54_119 ENOG4105W42 Veg protein AS54_1195 ENOG4105ENX hydrolase AS54_1196 ENOG4107RN3 metallophosphoesterase AS54_1198 ENOG4107TVP HD domain protein AS54_12 ENOG41067SE Tetr family transcriptional regulator AS54_1200 ENOG4108AEY RNA polymerase sigma factor AS54_1201 ENOG41086D8 Transcriptional regulator AS54_1203 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS54_1207 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AS54_1211 ENOG4105ZU5 s-layer protein AS54_1212 ENOG4107QP3 malate synthase g AS54_1215 ENOG4105VEQ Cold shock protein AS54_122 ENOG4105DFT pur operon repressor AS54_123 ENOG4105KME endoribonuclease L-psp AS54_1232 ENOG4105ERH Fumarylacetoacetate hydrolase AS54_1237 ENOG4105CAQ asparagine synthetase AS54_1238 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AS54_1239 ENOG4105CH6 catalase AS54_1240 ENOG4105BZU Histidine kinase AS54_1244 ENOG4105QNR S1 RNA binding domain protein AS54_1246 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AS54_1248 ENOG4107AYK membrAne AS54_1249 ENOG41073B9 AS54_1251 ENOG4108KP7 hydrolase AS54_1253 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AS54_1258 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AS54_1259 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AS54_126 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AS54_1262 ENOG4105C31 Tryptophanyl-tRNA synthetase AS54_1265 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AS54_1266 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS54_1268 ENOG4108JQ7 (ABC) transporter AS54_1269 ENOG4105UQX Mate efflux family protein AS54_127 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AS54_1273 ENOG4108ZCF integral membrane protein AS54_1275 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AS54_1277 ENOG4105DPN Oligoendopeptidase f AS54_1280 ENOG4108Z18 K06886 hemoglobin AS54_1281 ENOG4105MIX Adenylate cyclase AS54_1284 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AS54_1285 ENOG4105EMS pseudouridine synthase AS54_1289 ENOG4105K64 Glycosyl transferase, family 2 AS54_129 ENOG4108JA2 transcriptioN-repair coupling factor AS54_1293 ENOG4107TVC Glycosyl transferase, family 2 AS54_1297 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AS54_1298 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AS54_130 ENOG4108M14 stage v sporulation protein t AS54_1300 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AS54_1314 ENOG4105CK7 Sodium proline symporter AS54_1315 ENOG4105CRQ synthase (Component I) AS54_1316 ENOG4105DDQ anthranilate synthase AS54_132 ENOG4108IY2 MazG family AS54_133 ENOG41082I2 s4 domain protein AS54_1333 ENOG4105C7S Dehydrogenase AS54_1335 ENOG4105VZ8 Transcriptional regulator AS54_134 ENOG4105VYY sporulation protein yabp AS54_1359 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AS54_1362 ENOG4108IUX (ABC) transporter AS54_1363 ENOG4105RHA ABC transporter, permease AS54_1366 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AS54_1368 ENOG4105DZ1 carboxypeptidase AS54_1369 ENOG4105VFR signal peptidase AS54_137 ENOG41060GV RNA binding s1 domain protein AS54_1375 ENOG4105C26 Dehydrogenase AS54_1377 ENOG4105F38 ABC transporter, permease AS54_1378 ENOG4105D38 putrescine abc transporter AS54_1379 ENOG4107RUE extracellular solute-binding protein family 1 AS54_1381 ENOG4105EYF MMPL domain protein AS54_1383 ENOG4108YBP pseudouridine synthase AS54_1385 ENOG4105K4I Scp-like extracellular AS54_1386 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AS54_1387 ENOG4105CQB FAD linked oxidase domain protein AS54_1390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS54_1391 ENOG4105BZU Histidine kinase AS54_1392 ENOG4105JXH GntR family transcriptional regulator AS54_1396 ENOG4106A3R peptidase AS54_1398 ENOG4108QTI )-transporter AS54_1399 ENOG4107TS3 membrane protein, TerC AS54_14 ENOG4105E0X reductase AS54_1400 ENOG4105CZN Potassium uptake protein AS54_1401 ENOG410681C small acid-soluble spore protein AS54_1402 ENOG4108Z7G MaoC domain protein dehydratase AS54_1406 ENOG4105CHR reductase AS54_1408 ENOG4105MWK D-amino acid dehydrogenase, small subunit AS54_1412 ENOG4105C4Y ABC transporter AS54_1413 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AS54_1414 ENOG4107RCV ABC transporter, permease AS54_1418 ENOG4105E98 transcriptional regulator DeoR family AS54_142 ENOG4108UGV hypoxanthine phosphoribosyltransferase AS54_1421 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AS54_1423 ENOG4105PXI polysaccharide deacetylase AS54_1425 ENOG4105BZU Histidine kinase AS54_1426 ENOG41090MY MarR family Transcriptional regulator AS54_1428 ENOG4106DF1 AS54_143 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AS54_1430 ENOG4105BZU Histidine kinase AS54_1432 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AS54_1433 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AS54_1441 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AS54_1442 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AS54_1443 ENOG41079K6 HNH endonuclease AS54_1444 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AS54_1445 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AS54_1446 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AS54_1447 ENOG4105CZV ABC transporter AS54_1449 ENOG4105CJ1 ABC, transporter AS54_1457 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AS54_1458 ENOG4105EA8 2-Nitropropane dioxygenase AS54_1459 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AS54_146 ENOG4105C6T cysteine synthase AS54_1461 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AS54_1466 ENOG4105NQC Flavodoxin AS54_147 ENOG4105CRQ synthase (Component I) AS54_148 ENOG4105DDQ anthranilate synthase AS54_1480 ENOG4105CZN Potassium uptake protein AS54_1481 ENOG41063Y9 AS54_1482 ENOG4105KBJ sporulation protein ytfj AS54_1487 ENOG4105CM2 brancheD-chain amino acid aminotransferase AS54_1488 ENOG4105C7K acetolactate synthase AS54_1489 ENOG4108ZP8 Acetolactate synthase small subunit AS54_149 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AS54_15 ENOG4106F5Q Membrane AS54_150 ENOG4105EEI dihydropteroate synthase AS54_1504 ENOG4107RVV histidinol phosphate phosphatase, hisj family AS54_1507 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AS54_1508 ENOG4105E0M Sulfatase AS54_151 ENOG4105KRF dihydroneopterin aldolase AS54_1510 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AS54_1514 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AS54_1515 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AS54_1517 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AS54_1518 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AS54_1519 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AS54_152 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AS54_1520 ENOG4105C8J )-transporter AS54_1526 ENOG4105DFD Na H antiporter AS54_1530 ENOG4105ENE Histidine kinase AS54_1531 ENOG4105WH1 Two component transcriptional regulator luxr family AS54_1535 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AS54_154 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AS54_1544 ENOG4105CJ3 phosphate transporter AS54_1545 ENOG4107GRR phosphate transport regulator AS54_1546 ENOG4105BZ4 penicillin-binding protein AS54_1549 ENOG4105BZU Histidine kinase AS54_1550 ENOG4105I3N Conserved Protein AS54_1553 ENOG4105BZU Histidine kinase AS54_1560 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AS54_1561 ENOG4105DZ1 carboxypeptidase AS54_1562 ENOG4108JIC nucleoside recognition domain protein AS54_1564 ENOG4105FE9 pseudouridine synthase AS54_1566 ENOG4107TWT Cytochrome c biogenesis protein AS54_1567 ENOG4105CRE cytochrome C AS54_1568 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS54_1569 ENOG4105BZU Histidine kinase AS54_1570 ENOG4108WBT adenosyltransferase AS54_1571 ENOG41063SB peptidase AS54_1573 ENOG4108SAX Membrane AS54_1576 ENOG4105C9U ATP-dependent DNA helicase RecQ AS54_1577 ENOG4105I7S Abortive infection protein AS54_1579 ENOG4107RGJ metallophosphoesterase AS54_1580 ENOG4107X2D transcriptional regulator, merr family AS54_1581 ENOG4108S6Z Negative regulator of genetic competence AS54_1586 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AS54_1587 ENOG4107RB3 L-asparaginase AS54_1594 ENOG4105S2F AS54_1595 ENOG41065D1 AS54_1601 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AS54_1604 ENOG4105XXQ heptaprenyl diphosphate synthase component I AS54_1606 ENOG4105EAH synthase AS54_1610 ENOG4105CIH Imidazole acetol-phosphate transaminase AS54_1611 ENOG41068YB TPR repeat-containing protein AS54_1614 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AS54_1615 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AS54_1616 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AS54_1622 ENOG4108JYZ YitT family AS54_1623 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AS54_1626 ENOG4105FJR Lmbe family AS54_1627 ENOG4105CPK Glycosyl transferase (Group 1 AS54_1634 ENOG4105DVT helicase AS54_1635 ENOG4105YAC AS54_1639 ENOG4105CSM endonuclease III AS54_1641 ENOG4105BZ4 penicillin-binding protein AS54_1652 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AS54_1654 ENOG4105DVT helicase AS54_1655 ENOG4105CTD carboxy-peptidase AS54_1658 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AS54_1660 ENOG4105C2W permease AS54_1661 ENOG4105DHF Membrane AS54_1663 ENOG410890F Dynamin family AS54_1665 ENOG4108W0I acetyltransferase AS54_1667 ENOG4105KHC sulfurtransferase AS54_1671 ENOG4106032 Glutathionylspermidine synthase AS54_1677 ENOG4108SZE gCN5-related N-acetyltransferase AS54_1681 ENOG41081VK Ribonuclease AS54_1694 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AS54_1696 ENOG4107RWR Sodium hydrogen exchanger AS54_1697 ENOG4105CN5 Metallo-Beta-Lactamase AS54_1698 ENOG4108Z5V transcriptional regulator, merr family AS54_1700 ENOG4105H67 Protein of unknown function (DUF421) AS54_1701 ENOG41080C8 DUF218 domain AS54_1712 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AS54_1714 ENOG4107R0U MotA TolQ exbB proton channel AS54_1715 ENOG4105ER2 Ompa motb domain protein AS54_1716 ENOG4107YTP response regulator receiver protein AS54_1717 ENOG4105CBS Chea signal transduction histidine kinase AS54_1718 ENOG4105DD5 Flagellar motor switch protein AS54_1721 ENOG4105BZU Histidine kinase AS54_1725 ENOG4105E1Q flagellar hook-associated protein AS54_1726 ENOG4105DTJ flagellar hook-associated protein AS54_1727 ENOG4107TPX flagellar hook-associated AS54_1730 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AS54_1731 ENOG4108ZC9 flagellar basal-body rod protein flgc AS54_1732 ENOG41075Z6 flagellar hook-basal body complex protein fliE AS54_1733 ENOG4107U2N Flagellar M-ring protein AS54_1734 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AS54_174 ENOG4108Z0C Uvrb UvrC protein AS54_1740 ENOG4105BZE flagellar hook protein, FlgE AS54_1743 ENOG4107R88 Chemotaxis protein (CheV) AS54_1745 ENOG4105I03 Flagellin AS54_1746 ENOG4105I03 Flagellin AS54_1747 ENOG4105E4C Lytic transglycosylase catalytic AS54_1749 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AS54_1750 ENOG4105DD5 Flagellar motor switch protein AS54_1752 ENOG4105CN7 Flagellar biosynthetic protein FliP AS54_1753 ENOG4105VS8 Flagellar biosynthetic protein fliq AS54_1755 ENOG4105D00 flagellar biosynthetic protein flhB AS54_1756 ENOG4105D7B Flagellar biosynthesis protein flha AS54_1757 ENOG4105FZW flagellar biosynthesis regulator FlhF AS54_1758 ENOG4105KTQ flagellar basal-body rod protein AS54_1759 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AS54_1764 ENOG41062JF Transcriptional regulator AS54_1768 ENOG4105KAC Antibiotic biosynthesis monooxygenase AS54_177 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AS54_1773 ENOG4105DUM transcriptional regulator, lysR family AS54_1774 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AS54_1775 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AS54_1776 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AS54_1777 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AS54_1784 ENOG4105CVJ phosphoglycerate mutase AS54_1786 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AS54_1788 ENOG4105K56 Transcriptional regulator AS54_179 ENOG4105CTP PilT protein domain protein AS54_1790 ENOG4105CAQ asparagine synthetase AS54_1794 ENOG4105PGM cation diffusion facilitator family transporter AS54_1796 ENOG4105DRR Transcriptional regulator, GntR family AS54_1797 ENOG4108UZ3 Transporter AS54_1798 ENOG4105CKI cobalamin synthesis protein AS54_1799 ENOG4108PJD permease AS54_18 ENOG4105DY9 regulatoR AS54_1802 ENOG4105DFD Na H antiporter AS54_1803 ENOG4105C9Q fumarate hydratase class II AS54_1806 ENOG4107QJQ Mate efflux family protein AS54_1807 ENOG4105EC3 peptidase S51, dipeptidase E AS54_1811 ENOG4107QIV Cytochrome c biogenesis protein AS54_1817 ENOG4106BRA Membrane AS54_1824 ENOG4105CJ1 ABC, transporter AS54_1828 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AS54_183 ENOG4105D7W serine acetyltransferase AS54_1830 ENOG4108IJ0 Aspartate ammonia-lyase AS54_1831 ENOG4105C6K Malic enzyme AS54_1843 ENOG4105FVX AS54_1851 ENOG4105CSR polyphosphate kinase 2 AS54_1852 ENOG4105U3E Transcriptional regulator AS54_1854 ENOG4105DXI Major Facilitator superfamily AS54_1856 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AS54_1858 ENOG4105EU0 Major facilitator Superfamily AS54_1859 ENOG4105C6T cysteine synthase AS54_186 ENOG4105C2N RNA methyltransferase TrmH family group 3 AS54_1863 ENOG4105C8J )-transporter AS54_1865 ENOG4105X5K response regulator receiver protein AS54_1866 ENOG4105H67 Protein of unknown function (DUF421) AS54_1869 ENOG4106KE4 Dehydrogenase AS54_187 ENOG4105M0M Tetracycline resistance protein AS54_1873 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AS54_1874 ENOG4105CHR reductase AS54_1875 ENOG4105CM2 brancheD-chain amino acid aminotransferase AS54_1876 ENOG4105C7K acetolactate synthase AS54_1878 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AS54_188 ENOG4105QIV RNA polymerase AS54_1880 ENOG4105C7B Threonine dehydratase AS54_1885 ENOG4105C6X Major Facilitator AS54_1886 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AS54_1890 ENOG4105DY9 regulatoR AS54_1891 ENOG4105CYC Transferase AS54_1895 ENOG4108IBT Inherit from COG: transposase AS54_1898 ENOG4105VTR Integrase AS54_19 ENOG4108HRK Histidine kinase AS54_190 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AS54_1900 ENOG41067QW Transcriptional regulator AS54_1911 ENOG4105YQ0 AS54_1912 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AS54_195 ENOG4107Y49 methyltransferase AS54_1966 ENOG41068WN AS54_1967 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS54_1971 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AS54_1974 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AS54_1976 ENOG4105C0X amino acid AS54_198 ENOG4105XPM ribosomal protein AS54_1981 ENOG4107RHR regulatoR AS54_1983 ENOG4105D9N nucleoside AS54_1984 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AS54_1989 ENOG4107RAQ aminopeptidase AS54_1990 ENOG4107R16 Multicopper oxidase AS54_1999 ENOG4108T5E Copper resistance protein AS54_2 ENOG4106YBV Methyl-accepting chemotaxis AS54_20 ENOG4107RGD Major Facilitator superfamily AS54_2000 ENOG4105KTB nuclear export factor GLE1 AS54_2002 ENOG4107RT3 EamA-like transporter family AS54_2003 ENOG4105GZI Transcriptional regulator AS54_2004 ENOG4108Z40 Transcriptional regulator AS54_2005 ENOG4107ZXU DSBA oxidoreductase AS54_2006 ENOG4108TVJ Nitroreductase AS54_2008 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AS54_2009 ENOG4106F5Q Membrane AS54_2010 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AS54_2012 ENOG4105CKI cobalamin synthesis protein AS54_2016 ENOG4108Z7G MaoC domain protein dehydratase AS54_2017 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AS54_2019 ENOG4105C0Z ABC transporter AS54_2020 ENOG4108IV0 ABC, transporter AS54_2021 ENOG4105C32 Amino acid ABC transporter (Permease) AS54_2023 ENOG4105EGI Transcriptional regulator AS54_2029 ENOG4105C4M (Ubiquinol oxidase) subunit I AS54_2030 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AS54_2031 ENOG4108JJ9 ABC, transporter AS54_2032 ENOG4108JJ8 (ABC) transporter AS54_2035 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AS54_2040 ENOG4105BZ1 (ABC) transporter AS54_2041 ENOG4105EFI regulatoR AS54_2042 ENOG4105BZU Histidine kinase AS54_2044 ENOG4108VQJ O-methyltransferase AS54_2045 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AS54_2046 ENOG4108ZJ4 polysaccharide deacetylase AS54_2050 ENOG4105D6E homoserine dehydrogenase AS54_2055 ENOG4108KGH TRANSCRIPTIONal AS54_2057 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS54_2058 ENOG4105BZU Histidine kinase AS54_2059 ENOG4107VMI polysaccharide deacetylase AS54_2061 ENOG4105KT7 mgtC SapB transporter AS54_2062 ENOG4105VRR gCN5-related N-acetyltransferase AS54_2064 ENOG4105DUU IucA IucC family protein AS54_2065 ENOG4105CEY Amp-dependent synthetase and ligase AS54_2068 ENOG4108WBH protein TIM barrel AS54_2069 ENOG4105YWU small acid-soluble spore protein AS54_2071 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AS54_2072 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AS54_2094 ENOG4105EFC phage portal protein HK97 family AS54_2101 ENOG4105KRN Transcriptional regulator, abrb family AS54_2103 ENOG4105YVS arsR family transcriptional regulator AS54_2104 ENOG4107SET aldo keto reductase AS54_2105 ENOG4107XZQ multidrug resistance protein AS54_2110 ENOG4105C8Q Methyl-accepting chemotaxis AS54_2113 ENOG4108K88 Membrane AS54_2114 ENOG4108WPJ Ferritin-like domain AS54_2117 ENOG4105DEN Luciferase family AS54_2120 ENOG4105VMI -acetyltransferase AS54_2121 ENOG4107QM2 Aldo Keto reductase AS54_2122 ENOG4105CKI cobalamin synthesis protein AS54_2126 ENOG4108IBT Inherit from COG: transposase AS54_2127 ENOG4105DSE periplasmic solute binding protein AS54_2129 ENOG4105K4T epimerase AS54_2131 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AS54_2136 ENOG4105CVJ phosphoglycerate mutase AS54_2140 ENOG4107T5V SNARE associated Golgi AS54_2143 ENOG4108PJD permease AS54_2145 ENOG4108S4H thioesterase Superfamily protein AS54_2146 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AS54_2150 ENOG4105SXS Protein of unknown function (DUF456) AS54_2151 ENOG4105C37 (CBS) domain AS54_2155 ENOG4108Z7R Chaperone CsaA AS54_2158 ENOG4108ZRV stage ii sporulation protein p AS54_2160 ENOG4108VXD carboxy-peptidase AS54_2162 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AS54_2166 ENOG4105EFA 4-hydroxyphenylacetate AS54_2168 ENOG4105U1N riboflavin AS54_2171 ENOG4105KME endoribonuclease L-psp AS54_2177 ENOG41069HH 4-oxalocrotonate tautomerase AS54_2179 ENOG4108X4Q Hydrolase AS54_2181 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AS54_2182 ENOG4107RBS Methyltransferase AS54_2185 ENOG41087PP glycosyltransferase MGT family AS54_2186 ENOG4108JYZ YitT family AS54_2187 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AS54_219 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AS54_2193 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AS54_2209 ENOG4105KBJ sporulation protein ytfj AS54_2214 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AS54_2218 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AS54_2219 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AS54_2221 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AS54_2222 ENOG4105EMN RNA polymerase sigma factor AS54_2225 ENOG4105CNW domain protein AS54_2227 ENOG4108V06 Glutathione peroxidase AS54_2230 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AS54_2234 ENOG4108IUE nitrate reductase beta subunit AS54_2235 ENOG4105R3A Nitrate reductase AS54_2237 ENOG4107V6Q Cyclic nucleotide-binding domain AS54_2238 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AS54_2239 ENOG4105D06 uba thif-type nad fad binding protein AS54_224 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AS54_2240 ENOG4105CVM Molybdenum cofactor synthesis domain protein AS54_2241 ENOG4108ZAF Molybdopterin AS54_2245 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AS54_2246 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AS54_2247 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AS54_2248 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AS54_2249 ENOG4108IFG nitrite reductase, (NAD(P)H) AS54_2250 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AS54_2257 ENOG4105MCT stage V sporulation protein S AS54_226 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AS54_2265 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AS54_2271 ENOG4105C5H ABC transporter AS54_2274 ENOG4108UUM single-stranded DNA-binding protein AS54_228 ENOG41067V7 50S ribosomal protein L36 AS54_2280 ENOG4107YX5 Pfam:DUF548 AS54_2288 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AS54_2289 ENOG4105C5S asparaginyl-tRNA synthetase AS54_2293 ENOG4105EC2 ftsk spoIIIe AS54_23 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AS54_2311 ENOG4105BZW Glycerate kinase AS54_2312 ENOG4107QPK )-transporter AS54_2313 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS54_2314 ENOG41062D9 Histidine kinase AS54_2317 ENOG4105C8J )-transporter AS54_2321 ENOG4107XGZ Hydrolase AS54_2322 ENOG4105CY2 Citrate transporter AS54_2323 ENOG4105C0A alcohol dehydrogenase AS54_2326 ENOG4105KD7 acetyltransferase AS54_2327 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AS54_2332 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AS54_2336 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AS54_234 ENOG4108JJB ABC transporter AS54_2340 ENOG4107RVG penicillin-binding protein AS54_2342 ENOG4105E9Q Acyl-transferase AS54_2343 ENOG4108UT2 hemolysin iii AS54_2345 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AS54_2347 ENOG4108RCR degv family AS54_2348 ENOG4105E8R UPF0173 metal-dependent hydrolase AS54_2349 ENOG4108KF3 Electron transport protein SCO1 SenC AS54_235 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AS54_2350 ENOG4107Y70 Heat shock protein AS54_2351 ENOG4105CAQ asparagine synthetase AS54_2355 ENOG4108MES Periplasmic binding protein AS54_2356 ENOG4105F0I Aminotransferase AS54_236 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AS54_2363 ENOG4105D8X mechanosensitive ion channel AS54_2364 ENOG4105BZU Histidine kinase AS54_2365 ENOG4105WH1 Two component transcriptional regulator luxr family AS54_2366 ENOG4106KNT transcriptional regulator AS54_2372 ENOG4105CMG Carbohydrate kinase AS54_2378 ENOG4108IJ8 ABC transporter AS54_2379 ENOG4105E90 ABC transporter AS54_2386 ENOG4105C37 (CBS) domain AS54_2391 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AS54_2394 ENOG4107S4Y M20 DapE family protein YgeY AS54_2395 ENOG4108TSC N-acetyltransferase AS54_2396 ENOG4108JUB Transcriptional regulator AS54_2397 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AS54_2405 ENOG4108N23 SpoOM-related protein AS54_2407 ENOG410841Q phosphoesterase PA-phosphatase related protein AS54_2408 ENOG4105SZ6 Thioredoxin AS54_241 ENOG4105D1F ATP-binding protein AS54_2420 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AS54_2431 ENOG4105BZ4 penicillin-binding protein AS54_2432 ENOG4105CZM Major Facilitator AS54_2433 ENOG4105CZM Major Facilitator AS54_2434 ENOG4105W8X HesB YadR YfhF-family protein AS54_2436 ENOG4105DXD 2-methylcitrate dehydratase AS54_2437 ENOG4105CR4 methylisocitrate lyase AS54_2438 ENOG4105C1G acyl-Coa dehydrogenase AS54_2439 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AS54_244 ENOG4108NMV polysaccharide deacetylase AS54_2441 ENOG4105N14 lysine exporter protein LysE YggA AS54_2442 ENOG4105E39 Enoyl-CoA hydratase AS54_2445 ENOG4107RFY SbcCD D subunit AS54_2446 ENOG4105EYH Exonuclease AS54_2450 ENOG4105FCD Major Facilitator AS54_2451 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AS54_2452 ENOG4105E4F Isochorismate synthase AS54_2453 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AS54_2454 ENOG4105WQI isochorismatase AS54_2455 ENOG4105CEY Amp-dependent synthetase and ligase AS54_2456 ENOG4105WQT MbtH domain protein AS54_2457 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS54_2460 ENOG4105K70 DNA-binding protein AS54_2464 ENOG4105BZG amino acid carrier protein AS54_2468 ENOG4105FE9 pseudouridine synthase AS54_2469 ENOG4105C22 threonyL-tRNA synthetase AS54_2471 ENOG4105C19 ABC transporter AS54_2473 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AS54_2478 ENOG4108D32 Methyltransferase AS54_2485 ENOG41081I9 integral membrane protein AS54_2488 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AS54_2490 ENOG4105EYF MMPL domain protein AS54_2495 ENOG4105WCN acetyltransferase AS54_25 ENOG4105IW1 AmiS UreI transporter AS54_2501 ENOG4105C1Q protoporphyrinogen oxidase AS54_2503 ENOG41089UC methyltransferase, type 11 AS54_2504 ENOG41068WN AS54_2506 ENOG4105VEQ Cold shock protein AS54_2511 ENOG4107V2S Transcriptional regulator AS54_2512 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AS54_2515 ENOG4105DND Transcriptional regulator AS54_2516 ENOG4108RPX mosc domain containing protein AS54_2519 ENOG4105BZ1 (ABC) transporter AS54_2520 ENOG4105BZ1 (ABC) transporter AS54_2524 ENOG4108JCI Transcriptional regulator AS54_2530 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AS54_2533 ENOG4108KPJ rna polymerase sigma factor AS54_2538 ENOG4105F32 YngK protein AS54_2543 ENOG4105RD7 BadF BadG BcrA BcrD AS54_2545 ENOG4107STF Involved in phosphonate degradation (By similarity) AS54_2550 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AS54_2553 ENOG4105C1J atp-dependent rna helicase AS54_2555 ENOG4108RZE Tetr family transcriptional regulator AS54_2559 ENOG41088CC tellurite resistance protein tehB AS54_2561 ENOG4107RA9 decarboxylase AS54_2562 ENOG4105VTR Integrase AS54_2576 ENOG4107RA9 decarboxylase AS54_2578 ENOG41090HR transcriptional regulator AS54_2585 ENOG4105CIN aminoacyl-histidine dipeptidase AS54_2588 ENOG4105EQK -acetyltransferase AS54_2591 ENOG4107RVG penicillin-binding protein AS54_2594 ENOG4107RF6 penicillin-binding protein AS54_2595 ENOG4107RF6 penicillin-binding protein AS54_2598 ENOG4105ETE Transcriptional regulator (LacI family AS54_2599 ENOG4105IE8 Alpha-ketoglutarate permease AS54_260 ENOG4105C8B TIGR00159 family AS54_2600 ENOG4105CK5 oxidoreductase AS54_2605 ENOG4105D2N Aldolase AS54_2606 ENOG4105DH8 myo-inositol catabolism AS54_261 ENOG4107U5W ybbr family AS54_2611 ENOG4105CGH 5'-nucleotidase AS54_2613 ENOG4107JM4 Tetratricopeptide repeat AS54_2614 ENOG4105VZ8 Transcriptional regulator AS54_2617 ENOG4108VXD carboxy-peptidase AS54_2620 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity AS54_2621 ENOG41067SE Tetr family transcriptional regulator AS54_2622 ENOG4105C5H ABC transporter AS54_2623 ENOG4105BZU Histidine kinase AS54_2627 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AS54_2631 ENOG4105C1G acyl-Coa dehydrogenase AS54_2632 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AS54_2633 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AS54_2634 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AS54_2635 ENOG4105E39 Enoyl-CoA hydratase AS54_2636 ENOG4107QX3 carboxylase AS54_2637 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AS54_2640 ENOG4105DBI uridine monophosphokinase AS54_2647 ENOG4105T9C HD domain AS54_2648 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AS54_2656 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AS54_2656 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AS54_2661 ENOG4107Y80 Major Facilitator superfamily AS54_2663 ENOG41089UC methyltransferase, type 11 AS54_267 ENOG4105CMG Carbohydrate kinase AS54_2679 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein AS54_2681 ENOG4105DK7 lysyl-tRNA synthetase AS54_269 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AS54_2699 ENOG4105ETU transcriptional activator (TenA AS54_27 ENOG4105CMR udp-glucose 4-epimerase AS54_270 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AS54_2723 ENOG410667J hydrolase AS54_2724 ENOG4105BZU Histidine kinase AS54_2725 ENOG4107RF6 penicillin-binding protein AS54_2732 ENOG4108HGU Histidine kinase AS54_2734 ENOG4105RHY Pfam:UPF0157 AS54_2735 ENOG4105CB2 alcohol dehydrogenase AS54_2736 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AS54_2737 ENOG4105CJN penicillin-binding protein AS54_2738 ENOG4108IG5 Transcriptional regulator AS54_2739 ENOG4105CHR reductase AS54_2741 ENOG4105FQP Beta-lactamase AS54_2747 ENOG4108V4B ThiJ pfpI AS54_2750 ENOG4107Y80 Major Facilitator superfamily AS54_2754 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AS54_2758 ENOG4107Y9U Membrane AS54_276 ENOG4108PSK reductase AS54_2765 ENOG4105FCD Major Facilitator AS54_2766 ENOG4105E09 nadh pyrophosphatase AS54_2767 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AS54_2768 ENOG4108Z4K mutator MutT protein AS54_277 ENOG4108UMI ABC transporter, permease AS54_2773 ENOG4107TB6 phosphoglycerate mutase AS54_2775 ENOG4108XI2 Domain of unknown function (DUF1963) AS54_278 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AS54_2780 ENOG4108NRW Phospholipase, patatin family AS54_2781 ENOG4105KWG Pfam:DUF1696 AS54_2788 ENOG4105PKS Excinuclease abc c subunit domain protein AS54_279 ENOG4105D01 (LipO)protein AS54_2795 ENOG4107VFR oxidoreductase AS54_2799 ENOG4105PAD Hydrolase AS54_28 ENOG4108UT2 hemolysin iii AS54_280 ENOG4105EE1 crotonyl-CoA reductase AS54_2803 ENOG4108IUM Glycogen debranching enzyme AS54_2809 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AS54_2810 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AS54_2812 ENOG4105FDR Membrane AS54_282 ENOG4105IQ5 FAD linked oxidase domain protein AS54_2823 ENOG4105MSI germination protein ypeb AS54_2830 ENOG4107Z3H Transcriptional regulator, TetR family AS54_2835 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AS54_2838 ENOG4108MK9 spermidine N(1)-acetyltransferase AS54_2839 ENOG4105E98 transcriptional regulator DeoR family AS54_2843 ENOG41062ES Transcriptional regulator AS54_2847 ENOG4107QKR Dehydrogenase AS54_2849 ENOG4107RUY (E1 component), alpha subunit AS54_285 ENOG4105C2C drug resistance transporter, Bcr CflA AS54_2851 ENOG4105E1F short-chain dehydrogenase reductase AS54_2852 ENOG4105RHY Pfam:UPF0157 AS54_2853 ENOG4105DBI uridine monophosphokinase AS54_2855 ENOG4105M6F mutator MutT protein AS54_2860 ENOG4107SQ8 Glycine betaine AS54_2861 ENOG4108IJ7 Glycine betaine AS54_2866 ENOG4105E66 phosphoriboisomerase A AS54_2867 ENOG41082BV acetyltransferase AS54_2868 ENOG4108M1A Chitin-binding protein AS54_2871 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AS54_2872 ENOG4105MSB protein, conserved in bacteria AS54_2873 ENOG4107YB6 acetyltransferase, (GNAT) family AS54_2874 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AS54_288 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AS54_2880 ENOG4108Z7F N-acetyltransferase AS54_2884 ENOG4105EEM helicase AS54_2888 ENOG4105C9U ATP-dependent DNA helicase RecQ AS54_289 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS54_2897 ENOG4108M1A Chitin-binding protein AS54_290 ENOG4105C3U ABC transporter AS54_2900 ENOG4105BZG amino acid carrier protein AS54_2901 ENOG4105C26 Dehydrogenase AS54_2902 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AS54_2903 ENOG4105CTU Proline racemase AS54_2904 ENOG4105CTU Proline racemase AS54_2905 ENOG41080HI glycine oxidase AS54_2907 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein AS54_291 ENOG4108JQ7 (ABC) transporter AS54_2913 ENOG4107T5V SNARE associated Golgi AS54_2916 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AS54_2917 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AS54_2920 ENOG4105DTQ mandelate racemase muconate lactonizing AS54_2929 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AS54_2930 ENOG4105BZU Histidine kinase AS54_2931 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS54_2937 ENOG4105DPN Oligoendopeptidase f AS54_2938 ENOG4105DVH amino acid AS54_2940 ENOG4105EPR degv family AS54_2951 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AS54_2952 ENOG4106K7D Major facilitator family transporter AS54_2956 ENOG4107BMA Transglycosylase associated protein AS54_2959 ENOG41089UC methyltransferase, type 11 AS54_296 ENOG4105U5Y Transcriptional regulator AS54_2965 ENOG4105CHM Aminotransferase AS54_2968 ENOG4108ZMI UPF0477 protein AS54_2971 ENOG4105DVE abc transporter atp-binding protein AS54_2979 ENOG4105C02 permease AS54_298 ENOG4108J59 Extracellular solute-binding protein, family 5 AS54_2981 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AS54_2982 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AS54_2983 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AS54_2986 ENOG4105E09 nadh pyrophosphatase AS54_299 ENOG4108J59 Extracellular solute-binding protein, family 5 AS54_2990 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AS54_30 ENOG4105C1J atp-dependent rna helicase AS54_3004 ENOG4108ZCF integral membrane protein AS54_3005 ENOG4105E0M Sulfatase AS54_3006 ENOG4105C5H ABC transporter AS54_3008 ENOG4105EYF MMPL domain protein AS54_3009 ENOG41082JN Transcriptional regulator AS54_3013 ENOG4105CIH Imidazole acetol-phosphate transaminase AS54_3015 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AS54_302 ENOG4107XDY Nicotinamide Mononucleotide Transporter AS54_3023 ENOG41069ER domain protein AS54_3025 ENOG4105CY2 Citrate transporter AS54_3026 ENOG4105E39 Enoyl-CoA hydratase AS54_3027 ENOG4105J5T Amp-dependent synthetase and ligase AS54_3028 ENOG4108JUB Transcriptional regulator AS54_3032 ENOG4105D4B ABC, transporter AS54_3034 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AS54_3036 ENOG4105DKT Transcriptional regulator AS54_3037 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AS54_3039 ENOG41061GT Aldolase AS54_304 ENOG4105E0C molybdate abc transporter AS54_3044 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AS54_305 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AS54_3051 ENOG4105II7 pyrroline-5-carboxylate reductase AS54_3053 ENOG4107258 Transcriptional regulator AS54_3055 ENOG4105E0Y RtcB Protein AS54_3056 ENOG4105ECK Fatty Acid Desaturase AS54_3057 ENOG4105G6Z alkaline phosphatase AS54_3059 ENOG4105VMP Transcriptional regulator AS54_306 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AS54_3062 ENOG41090T1 Membrane AS54_3064 ENOG4108WCX response regulator AS54_3066 ENOG41068WN AS54_3072 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AS54_3081 ENOG4105CKK Glycosyl transferase, family 2 AS54_3083 ENOG4105C8Y Acetylornithine aminotransferase AS54_3084 ENOG4105CH6 catalase AS54_3093 ENOG4108TVJ Nitroreductase AS54_3094 ENOG4105FS7 Transcriptional regulator AS54_3102 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AS54_3104 ENOG4105CMR udp-glucose 4-epimerase AS54_3105 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AS54_3111 ENOG4108XET gCN5-related N-acetyltransferase AS54_3128 ENOG410635A Membrane AS54_313 ENOG4105F6E Acyl-transferase AS54_3130 ENOG4108IQI permease AS54_3132 ENOG4105F1N DNA alkylation repair AS54_3139 ENOG4107RF6 penicillin-binding protein AS54_3141 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AS54_3148 ENOG4105P4J Allophanate hydrolase, subunit 1 AS54_3149 ENOG4107258 Transcriptional regulator AS54_3151 ENOG4106N3A copper homeostasis protein cutc AS54_3152 ENOG4108ZRV stage ii sporulation protein p AS54_3153 ENOG4108ZHR arsR family transcriptional regulator AS54_3155 ENOG4105FDT acyl-CoA dehydrogenase AS54_3159 ENOG4105DWD nucleoside recognition domain protein AS54_3164 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AS54_317 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AS54_3179 ENOG4105E2A Dehydrogenase AS54_3182 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AS54_3185 ENOG4105CGH 5'-nucleotidase AS54_3186 ENOG41061CK Antibiotic biosynthesis monooxygenase AS54_3195 ENOG4106A3M Cytochrome p-450 AS54_3196 ENOG4105YA8 Transcriptional regulator AS54_320 ENOG4108RE7 deoxyribonuclease AS54_3200 ENOG4108606 TspO/MBR family AS54_3201 ENOG4105CVP deoxyribo-dipyrimidine photolyase AS54_3204 ENOG4108TWJ NADH dehydrogenase subunit 5 AS54_3205 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AS54_3208 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AS54_3209 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AS54_3210 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AS54_3213 ENOG4105C19 ABC transporter AS54_3216 ENOG4108NEV two component transcriptional regulator, LytTR family AS54_3217 ENOG4105DSE periplasmic solute binding protein AS54_3218 ENOG4105CC5 ABC transporter AS54_3219 ENOG4105DIK (ABC) transporter AS54_322 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AS54_3224 ENOG4105D6J arsenicaL-resistance protein AS54_3225 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AS54_3226 ENOG41085FC arsR family transcriptional regulator AS54_3230 ENOG4105F7F Chaperone AS54_3241 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AS54_3242 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS54_3244 ENOG4105IIP Membrane AS54_3247 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS54_3248 ENOG41062D9 Histidine kinase AS54_3253 ENOG4105K6H D-cysteine desulfhydrase AS54_3258 ENOG4108NNI Beta-lactamase domain-containing protein AS54_3259 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AS54_326 ENOG4105C5H ABC transporter AS54_3261 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AS54_3264 ENOG4105C88 aminopeptidase AS54_3267 ENOG4105JQZ Methyltransferase AS54_3271 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AS54_3274 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AS54_3277 ENOG4105BZU Histidine kinase AS54_328 ENOG4105DEF Extracellular solute-binding protein, family 5 AS54_3280 ENOG4108U05 Transcriptional regulator AS54_3281 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 AS54_3283 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AS54_3284 ENOG4105DJB Major Facilitator Superfamily AS54_3285 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AS54_3286 ENOG4107QR9 Iron-sulfur cluster binding protein AS54_3288 ENOG4106P55 Transcriptional regulator AS54_3293 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AS54_3296 ENOG4105CEP NADH dehydrogenase AS54_3297 ENOG4105D4Y metalloprotease AS54_3298 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AS54_33 ENOG4105DPN Oligoendopeptidase f AS54_330 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS54_3304 ENOG4106ANW SMI1_KNR4 AS54_331 ENOG4105C3U ABC transporter AS54_3310 ENOG4105TRI Hydrolase AS54_332 ENOG4108JQ7 (ABC) transporter AS54_3320 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AS54_3324 ENOG4105C44 Serine transporter AS54_3325 ENOG4105EJQ L-serine dehydratase AS54_3327 ENOG4105MZU cell filamentation protein AS54_3328 ENOG4108JPW Aminotransferase AS54_333 ENOG410667J hydrolase AS54_3331 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AS54_3333 ENOG4105DVH amino acid AS54_3337 ENOG4108JQ1 Dehydrogenase AS54_3341 ENOG4108AEY RNA polymerase sigma factor AS54_3344 ENOG41082W1 Cupin 2, conserved barrel domain protein AS54_3345 ENOG410874W AraC family transcriptional regulator AS54_3348 ENOG4108IBT Inherit from COG: transposase AS54_3351 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AS54_3353 ENOG4108IG5 Transcriptional regulator AS54_3362 ENOG4108ISG Major Facilitator AS54_3364 ENOG4107MII Sugar-specific transcriptional regulator TrmB AS54_3365 ENOG4105CZM Major Facilitator AS54_3369 ENOG4105DA5 (ABC) transporter AS54_3370 ENOG41069JR AS54_3372 ENOG4105RXJ AS54_3373 ENOG4105KPY Small multidrug resistance protein AS54_3374 ENOG4105KBX Transcriptional regulator, TetR family AS54_3375 ENOG4107AUC AS54_3377 ENOG4105CRW Short chain fatty acid transporter AS54_3379 ENOG4105DYS nad(p)h dehydrogenase (quinone) AS54_3385 ENOG4108JJB ABC transporter AS54_3386 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AS54_339 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AS54_3391 ENOG4108K8S endonuclease I AS54_3392 ENOG4108Z66 YbaK ebsC protein AS54_3394 ENOG4105WH1 Two component transcriptional regulator luxr family AS54_3398 ENOG4105KVH Transcriptional regulator AS54_3399 ENOG4108RCM Nitroreductase AS54_340 ENOG4105ERH Fumarylacetoacetate hydrolase AS54_3403 ENOG4108PSK reductase AS54_3405 ENOG4105CJ1 ABC, transporter AS54_3411 ENOG4105D7V transposase AS54_3419 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AS54_342 ENOG4108SC4 )-transporter AS54_3420 ENOG4105DKQ ROK family AS54_3421 ENOG4106UW1 Major Facilitator superfamily AS54_3422 ENOG4108UW5 maltose o-acetyltransferase AS54_3424 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AS54_3426 ENOG4105C31 Tryptophanyl-tRNA synthetase AS54_343 ENOG4105CPF Cell wall formation (By similarity) AS54_3432 ENOG4105DMQ Methyltransferase AS54_3434 ENOG4105EV4 Multidrug resistance protein mdtH AS54_344 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AS54_3440 ENOG4105C37 (CBS) domain AS54_3443 ENOG4105DDN Pentapeptide repeat-containing protein AS54_3445 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AS54_3446 ENOG4105CMG Carbohydrate kinase AS54_3447 ENOG4105C6Z Gluconate AS54_3448 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AS54_3451 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AS54_3456 ENOG4105C44 Serine transporter AS54_346 ENOG4107ZXI Rhomboid family AS54_3462 ENOG4108TZY GntR Family Transcriptional Regulator AS54_3463 ENOG4105D9R oxidoreductase AS54_3470 ENOG4105JAB phenazine biosynthesis protein, phzf family AS54_3472 ENOG4105CHR reductase AS54_3474 ENOG4105KNA -acetyltransferase AS54_3476 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AS54_3477 ENOG4105KVH Transcriptional regulator AS54_3481 ENOG4108ZJ4 polysaccharide deacetylase AS54_3489 ENOG4105KAF membrAne AS54_349 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AS54_3498 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AS54_350 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AS54_3501 ENOG4107YXZ hydrolase, family 25 AS54_3508 ENOG4105H3G oxidoreductase AS54_3517 ENOG4105K7K Transcriptional regulator AS54_3518 ENOG4105CIS alcohol dehydrogenase AS54_352 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AS54_3525 ENOG4108TN2 lmbE family AS54_3527 ENOG4107R3E Citrate transporter AS54_3530 ENOG4108MES Periplasmic binding protein AS54_3531 ENOG4105EHG Permease protein AS54_3532 ENOG4105DQ5 transport system permease protein AS54_3533 ENOG4105NX3 Membrane AS54_3534 ENOG4107ZY0 Phenazine biosynthesis-like protein AS54_3538 ENOG4107V2S Transcriptional regulator AS54_3542 ENOG4105C98 muts2 protein AS54_3546 ENOG4105E5K Alpha-amylase AS54_3547 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AS54_3548 ENOG4105DPN Oligoendopeptidase f AS54_3549 ENOG4108A04 Beta-lactamase AS54_3555 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AS54_3560 ENOG41082BM Transcriptional regulator, arsr family AS54_3561 ENOG4105CIS alcohol dehydrogenase AS54_3566 ENOG4105RHY Pfam:UPF0157 AS54_3568 ENOG4105C09 Bile acid AS54_3569 ENOG4105CQB FAD linked oxidase domain protein AS54_3573 ENOG4108UT6 Transferase hexapeptide repeat containing protein AS54_3575 ENOG4105K64 Glycosyl transferase, family 2 AS54_3576 ENOG4105E39 Enoyl-CoA hydratase AS54_3578 ENOG4105KT7 mgtC SapB transporter AS54_3581 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AS54_3582 ENOG41073R8 VanW family AS54_3584 ENOG4108R1P AS54_3588 ENOG4105VEQ Cold shock protein AS54_3592 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AS54_3598 ENOG4105DQ6 Transposase AS54_3602 ENOG4105DR5 peptidase AS54_3603 ENOG41065S2 pneumococcal vaccine antigen AS54_3604 ENOG4107YXZ hydrolase, family 25 AS54_3614 ENOG410904N short-chain dehydrogenase reductase AS54_3616 ENOG4106IQC argininosuccinate lyase AS54_3619 ENOG4108IA2 Sodium pantothenate symporter AS54_3621 ENOG4105C26 Dehydrogenase AS54_3622 ENOG4105CHR reductase AS54_3624 ENOG4105EWU Squalene--hopene cyclase AS54_3626 ENOG4105FR1 rard protein AS54_3627 ENOG410696E Membrane AS54_3630 ENOG4105D1F ATP-binding protein AS54_3632 ENOG4108ZAF Molybdopterin AS54_3633 ENOG4105CVM Molybdenum cofactor synthesis domain protein AS54_3634 ENOG4105D06 uba thif-type nad fad binding protein AS54_3635 ENOG4105TMB Formate nitrite transporter AS54_3637 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AS54_3638 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AS54_3640 ENOG4108JB9 formate dehydrogenase AS54_3642 ENOG4105E1K spore germination protein AS54_3654 ENOG4107QJT sodium dicarboxylate symporter AS54_3655 ENOG4108KGH TRANSCRIPTIONal AS54_3657 ENOG4105EMN RNA polymerase sigma factor AS54_3659 ENOG4105CIG ABC transporter AS54_3661 ENOG4105D9R oxidoreductase AS54_3664 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AS54_3665 ENOG4105K4P CoA-binding domain protein AS54_3666 ENOG4105C0H protease AS54_3667 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS54_3669 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AS54_3670 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AS54_3671 ENOG4105W8X HesB YadR YfhF-family protein AS54_3677 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AS54_3678 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AS54_3680 ENOG4108JJA ABC, transporter AS54_3681 ENOG4108I0Z Aconitate hydratase AS54_3687 ENOG4105E5W Transporter AS54_3689 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AS54_3693 ENOG4107F3J Amp-dependent synthetase and ligase AS54_3694 ENOG4107ZYJ bioY protein AS54_3695 ENOG4105CEY Amp-dependent synthetase and ligase AS54_37 ENOG4105C0H protease AS54_3706 ENOG4107AYK membrAne AS54_3708 ENOG4105BZU Histidine kinase AS54_3709 ENOG4105FBA Phospholipase Carboxylesterase AS54_3710 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AS54_3711 ENOG4105CK7 Sodium proline symporter AS54_3712 ENOG4105CBC glutamate synthase AS54_3713 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AS54_3714 ENOG4108VJ1 Transcriptional regulator (CarD family AS54_3715 ENOG4108903 Formimidoylglutamase AS54_372 ENOG4105K8N protein family UPF0079, ATPase AS54_3720 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AS54_3729 ENOG4107QIV Cytochrome c biogenesis protein AS54_373 ENOG41072GX Peptidase M22 Glycoprotease AS54_3731 ENOG4105CH2 amidohydrolase AS54_3733 ENOG4105CJ1 ABC, transporter AS54_3735 ENOG4107RSM transcriptional regulator AS54_3737 ENOG41067MG lrgb family AS54_374 ENOG410801F ribosomal-protein-alanine acetyltransferase AS54_3742 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AS54_3745 ENOG4105BZ1 (ABC) transporter AS54_3746 ENOG4105BZ1 (ABC) transporter AS54_3754 ENOG4105CGH 5'-nucleotidase AS54_3756 ENOG4108SVB resolvase AS54_376 ENOG4105C5H ABC transporter AS54_3760 ENOG4105K7K Transcriptional regulator AS54_3761 ENOG4105C5F glutamine synthetase AS54_3762 ENOG4105KV4 Transcriptional regulator AS54_3763 ENOG4105CXI aluminum resistance protein AS54_3764 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AS54_3765 ENOG4105EN6 Membrane AS54_3767 ENOG4106F1P AAA ATPase, central domain protein AS54_3773 ENOG41069ER domain protein AS54_3774 ENOG4105DM4 PTS System AS54_3775 ENOG4105DE4 1-phosphofructokinase AS54_3776 ENOG4105E98 transcriptional regulator DeoR family AS54_3777 ENOG4107QW4 alcohol dehydrogenase AS54_3778 ENOG4108SJC Membrane AS54_3781 ENOG4105C85 amino acid AS54_3785 ENOG4105TMB Formate nitrite transporter AS54_3786 ENOG4105K70 DNA-binding protein AS54_379 ENOG4108TYN CAAX amino terminal protease family protein AS54_3790 ENOG4105C59 p-type ATPase AS54_3791 ENOG410681U heavy metal transport detoxification protein AS54_3792 ENOG4105VPX protein, conserved in bacteria AS54_3794 ENOG4105NIV Esterase AS54_3795 ENOG4105E0A ABC, transporter AS54_3799 ENOG4105CGK Exodeoxyribonuclease III AS54_38 ENOG4105Q2H domain protein AS54_3801 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AS54_3802 ENOG4105D03 DNA-3-methyladenine glycosylase II AS54_3808 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AS54_3809 ENOG4105BZU Histidine kinase AS54_382 ENOG4107EV6 Inherit from COG: YD repeat protein AS54_3823 ENOG4105F0V Cell wall hydrolase AS54_3825 ENOG4105E0M Sulfatase AS54_3826 ENOG410890F Dynamin family AS54_3828 ENOG4107QHE Choloylglycine hydrolase AS54_3834 ENOG4105DQU oxidoreductase, subunit beta AS54_3835 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AS54_3836 ENOG4108IGT Dipeptidase AS54_3837 ENOG4105MCT stage V sporulation protein S AS54_3838 ENOG4105D48 metallophosphoesterase AS54_3842 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AS54_3845 ENOG4105XZV Protein of unknown function (DUF3243) AS54_3846 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AS54_385 ENOG4105C7N Xanthine uracil vitamin C permease AS54_3850 ENOG4105UIB (ABC) transporter AS54_3851 ENOG4108JQ9 ABC transporter AS54_3852 ENOG4105DIH basic membrane AS54_3853 ENOG4105FDP GntR family transcriptional regulator AS54_3854 ENOG4107QZI cell division protein FtsK AS54_3856 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AS54_3858 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AS54_3860 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AS54_3861 ENOG4108S0H Dipicolinic acid synthetase, b subunit AS54_3862 ENOG4105E35 Dipicolinate synthase subunit A AS54_3864 ENOG4105C1V Peptidase, M16 AS54_3868 ENOG4105DTN riboflavin biosynthesis protein ribF AS54_387 ENOG4105BZU Histidine kinase AS54_3871 ENOG4105W7A Protein of unknown function (DUF503) AS54_3873 ENOG4105VHM ribosomal protein AS54_3874 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AS54_3875 ENOG4105CHV Transcription elongation factor NusA AS54_3877 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AS54_3878 ENOG4105EKQ RNA-directed DNA polymerase AS54_3880 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AS54_3882 ENOG4105DZP Membrane-associated zinc metalloprotease AS54_3884 ENOG4105KNE Phosphatidate cytidylyltransferase AS54_3893 ENOG4108HE4 integrase family AS54_3895 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AS54_3896 ENOG4105C79 DNA protecting protein DprA AS54_3897 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AS54_3900 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AS54_3905 ENOG4105VB6 UPF0109 protein AS54_3909 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AS54_3910 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AS54_3913 ENOG4105CHR reductase AS54_3914 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AS54_3917 ENOG4105CB5 ATP-dependent DNA helicase recG AS54_3918 ENOG4105DP4 dak2 domain fusion protein ylov AS54_3919 ENOG4108ZAA Alkaline-shock protein AS54_3921 ENOG4105FJ0 thiamine AS54_3922 ENOG4105DJV ribulose-phosphate 3-epimerase AS54_3923 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AS54_3924 ENOG4105D9P serine threonine protein kinase AS54_3925 ENOG4108ZF3 Phosphatase AS54_3927 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AS54_3929 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AS54_393 ENOG4107ZXU DSBA oxidoreductase AS54_3930 ENOG4105C25 Primosomal protein n' AS54_3931 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AS54_3935 ENOG4105DSJ YicC domain protein AS54_3937 ENOG4105F23 Fibronectin-binding protein AS54_3938 ENOG4105DC7 peptidase M24 AS54_3950 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AS54_3955 ENOG4105C34 Pseudouridine synthase AS54_3960 ENOG4105DBK s4 domain protein AS54_3961 ENOG41067XK integral membrane protein AS54_3963 ENOG4105DFA alanine racemase domain protein AS54_3964 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AS54_3965 ENOG4105WR5 sporulation protein, YlmC YmxH family AS54_3967 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS54_3969 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AS54_3970 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AS54_3971 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AS54_3972 ENOG4105D4A Cell wall formation (By similarity) AS54_3973 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AS54_3974 ENOG4105CNI cell division protein FtsW AS54_3977 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AS54_3978 ENOG4105CJN penicillin-binding protein AS54_3979 ENOG4105CJN penicillin-binding protein AS54_3980 ENOG41068DC Essential cell division protein (By similarity) AS54_3987 ENOG4105KNH Nucleic acid-binding protein AS54_3989 ENOG41063PX domain protein AS54_3990 ENOG4105D78 K07001 NTE family protein AS54_3992 ENOG4105H20 Sporulation integral membrane protein YlbJ AS54_3993 ENOG4106H78 methyltransferase AS54_3997 ENOG4107TB6 phosphoglycerate mutase AS54_4 ENOG4108S4H thioesterase Superfamily protein AS54_4000 ENOG4106UY4 Inherit from COG: Scp-like extracellular AS54_4010 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AS54_4011 ENOG4105CNI cell division protein FtsW AS54_4014 ENOG4108IAB Phoh family AS54_4018 ENOG4105QA2 AS54_4019 ENOG4105CI3 gtp-binding protein typa AS54_4021 ENOG4105ECY inositol monophosphatase AS54_4025 ENOG4105CXN decarboxylase AS54_4035 ENOG4105CPP Dehydrogenase, E1 component AS54_4038 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AS54_4039 ENOG4108X4Q Hydrolase AS54_4041 ENOG4105CN5 Metallo-Beta-Lactamase AS54_4042 ENOG4107ZYR domain protein AS54_4049 ENOG4108XRC Protein of unknown function (DUF458) AS54_4051 ENOG4107IN1 Protein of unknown function (DUF1797) AS54_4054 ENOG4105EPM Diguanylate phosphodiesterase AS54_4055 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AS54_4058 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AS54_4060 ENOG4105UIN AS54_407 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS54_4071 ENOG4108HGU Histidine kinase AS54_4073 ENOG4105CHM Aminotransferase AS54_4074 ENOG4105FKQ transcriptional regulator AS54_4075 ENOG4105EG2 ABC transporter, permease AS54_4077 ENOG4107FKK extracellular solute-binding protein family 1 AS54_4079 ENOG4105CG3 alpha amylase, catalytic region AS54_4089 ENOG4105CHU acetyl-coa acetyltransferase AS54_4095 ENOG4105K7K Transcriptional regulator AS54_4096 ENOG4105DTD Dehydrogenase AS54_41 ENOG4105BZU Histidine kinase AS54_4100 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AS54_4108 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AS54_4109 ENOG4106TD9 Diguanylate cyclase AS54_4113 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AS54_4116 ENOG4105CID antiterminator AS54_4118 ENOG4105FDP GntR family transcriptional regulator AS54_412 ENOG4105SX7 Transporter AS54_4120 ENOG4105CE4 GlcNAc 6-P deacetylase AS54_4127 ENOG4107ZE5 PPIases accelerate the folding of proteins AS54_4128 ENOG4105PTM secreted protein AS54_4129 ENOG4105J7I hydrolase AS54_4131 ENOG4105G6R Stage v sporulation protein ae AS54_4133 ENOG4105CZ3 stage V sporulation protein ad AS54_4134 ENOG41090VF Stage v sporulation protein ac AS54_4138 ENOG4105C8J )-transporter AS54_4139 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS54_4141 ENOG41082AN stage II sporulation protein AS54_4142 ENOG4105DZ1 carboxypeptidase AS54_4143 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AS54_4144 ENOG4105DVE abc transporter atp-binding protein AS54_4150 ENOG4105D7N magnesium and cobalt transport protein CorA AS54_4155 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AS54_4157 ENOG4105I3K Ferric uptake regulator, Fur family AS54_4158 ENOG4105MZ9 stage II sporulation protein m AS54_4162 ENOG4105CPC Aldo Keto reductase AS54_4164 ENOG4105RHY Pfam:UPF0157 AS54_4168 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AS54_4170 ENOG4105ETE Transcriptional regulator (LacI family AS54_4171 ENOG4108YM7 Gcn5-related n-acetyltransferase AS54_4175 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AS54_4176 ENOG4108R6K riboflavin synthase, subunit alpha AS54_418 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AS54_4181 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AS54_4182 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AS54_4185 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AS54_4187 ENOG4105DFD Na H antiporter AS54_4188 ENOG4105CGH 5'-nucleotidase AS54_419 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AS54_4196 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AS54_4199 ENOG4108IXY short-chain dehydrogenase reductase AS54_42 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS54_420 ENOG4105C83 adenylosuccinate lyase AS54_4200 ENOG41069FQ Metallo-beta-lactamase superfamily AS54_4201 ENOG4105II7 pyrroline-5-carboxylate reductase AS54_4202 ENOG4105EJQ L-serine dehydratase AS54_4206 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AS54_4207 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AS54_4208 ENOG4105D9U N-acetyltransferase AS54_4210 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AS54_4211 ENOG4108QEG Membrane AS54_4212 ENOG4105CDA abc transporter atp-binding protein AS54_4213 ENOG4105E5Q amino acid AbC transporter AS54_4214 ENOG4108HW3 (ABC) transporter AS54_4216 ENOG4105G7B Protein of unknown function (DUF2992) AS54_4217 ENOG4105E09 nadh pyrophosphatase AS54_4219 ENOG4105C7S Dehydrogenase AS54_422 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AS54_4220 ENOG4105CPP Dehydrogenase, E1 component AS54_4224 ENOG4107RDP Dehydrogenase AS54_4226 ENOG4108JUB Transcriptional regulator AS54_4228 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AS54_4231 ENOG4107QQR Sporulation AS54_4232 ENOG4105S1Z Stage IV sporulation protein B AS54_4233 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AS54_4235 ENOG4105DX0 Hemolysin A AS54_4237 ENOG4105CTB Polyprenyl synthetase AS54_4242 ENOG4108ZSR alkaline shock protein AS54_4243 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AS54_4248 ENOG410644B Stage III sporulation protein af AS54_4250 ENOG4105KQ4 Stage iii sporulation protein ad AS54_4251 ENOG4108CQH stage III sporulation protein AC AS54_4252 ENOG4105KR5 Stage iii sporulation protein AS54_4253 ENOG4105CD2 stage iii sporulation protein aa AS54_4258 ENOG4105DC7 peptidase M24 AS54_4261 ENOG4105CBJ Metal-dependent enzyme AS54_4262 ENOG4107YBY Hydrolase AS54_4266 ENOG4105K7K Transcriptional regulator AS54_4269 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AS54_427 ENOG4108V3E phosphoribosylglycinamide formyltransferase AS54_4270 ENOG4105WZW rhodanese family AS54_4274 ENOG41080TC multidrug resistance protein AS54_4281 ENOG4105CJ1 ABC, transporter AS54_4282 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AS54_4288 ENOG4105C0D helicase AS54_429 ENOG4105C12 Phosphoribosylglycinamide synthetase AS54_4312 ENOG4105C3R Methionine synthase AS54_4314 ENOG4105C28 cystathionine AS54_4315 ENOG4105C28 cystathionine AS54_4318 ENOG4105C5X domain protein AS54_4320 ENOG4105DKQ ROK family AS54_4322 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AS54_4325 ENOG4108UTW Plays a role in the regulation of phosphate uptake AS54_4326 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AS54_4327 ENOG4105E2Z phosphate ABC transporter (Permease AS54_4328 ENOG4105C8U phosphate abc transporter AS54_4329 ENOG4105PWN phosphate abc transporter AS54_4330 ENOG4107RF6 penicillin-binding protein AS54_4332 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AS54_4337 ENOG4105N80 Ferric uptake regulator, Fur family AS54_4339 ENOG4105FDK ABC transporter AS54_434 ENOG4105C4R Atp-dependent dna helicase AS54_4340 ENOG4108JYZ YitT family AS54_4341 ENOG41069ZM Protein of unknown function (DUF2624) AS54_4346 ENOG4105EGD dinuclear metal center protein, YbgI family AS54_4349 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS54_4350 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AS54_4355 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AS54_4356 ENOG4105KG3 cytidine deaminase AS54_4357 ENOG4107YR5 Diacylglycerol kinase AS54_4359 ENOG4105CTJ Metal Dependent Phosphohydrolase AS54_4360 ENOG4105C9A Phoh family AS54_4362 ENOG41068P3 sporulation protein YqfC AS54_4363 ENOG4105KTH gatB Yqey AS54_4365 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AS54_4366 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AS54_4370 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AS54_4372 ENOG4105CSA Coproporphyrinogen iii oxidase AS54_4373 ENOG4105KVH Transcriptional regulator AS54_4378 ENOG4105TQK DNA polymerase iii, delta' subunit AS54_4380 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AS54_4381 ENOG4108UK2 deaminase AS54_4382 ENOG4105KQC Competence protein AS54_4384 ENOG4105DXX methyltransferase AS54_4386 ENOG4108WF2 Metal Dependent Phosphohydrolase AS54_4388 ENOG410812S Rna-binding protein AS54_4390 ENOG4105CQW ribosome biogenesis GTPase YqeH AS54_4391 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AS54_4394 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS54_4398 ENOG4108TVJ Nitroreductase AS54_440 ENOG4108W2Y isochorismatase AS54_4401 ENOG4105G6Z alkaline phosphatase AS54_4403 ENOG4108MUZ hydrolase AS54_441 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AS54_4410 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AS54_4411 ENOG4105MIR Phenylalanine 4-monooxygenase AS54_4413 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AS54_442 ENOG4108UMI ABC transporter, permease AS54_4421 ENOG4105S6R Iron-hydroxamate transporter permease subunit AS54_4422 ENOG4108V5C ABC transporter AS54_4424 ENOG4108EKI Dehydrogenase AS54_4425 ENOG4105C28 cystathionine AS54_443 ENOG4105D01 (LipO)protein AS54_4431 ENOG4107XRG penicillin-binding protein AS54_4434 ENOG4105CFP Peptidase U32 AS54_4435 ENOG4105XYU peptidase (U32 family) AS54_4436 ENOG4108VQJ O-methyltransferase AS54_4437 ENOG4105HHA aminodeoxychorismate lyase AS54_4443 ENOG4105C02 permease AS54_4446 ENOG41060CR AS54_4447 ENOG4105C7H Helicase, RecD TraA family AS54_4450 ENOG4105C3J Cysteine desulfurase AS54_4452 ENOG4105D1H recombination factor protein RarA AS54_4453 ENOG4108VCI transcription factor, rsfa family AS54_4454 ENOG4105CUZ uba thif-type nad fad binding protein AS54_4456 ENOG4105CUT histidyl-tRNA synthetase AS54_4459 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AS54_4461 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AS54_4462 ENOG41076HS cation diffusion facilitator family transporter AS54_4463 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AS54_4465 ENOG4105CKP Polysaccharide Biosynthesis Protein AS54_4466 ENOG4108QG2 Membrane AS54_4468 ENOG4105VIE preprotein translocase, subunit YajC AS54_447 ENOG410834F Transcriptional regulator AS54_4471 ENOG41061AI Protein of unknown function (DUF2905) AS54_4474 ENOG4108HUF Transporter AS54_4476 ENOG4108IPJ Membrane AS54_4477 ENOG4108IPJ Membrane AS54_4478 ENOG41082BM Transcriptional regulator, arsr family AS54_448 ENOG4107I77 yiaA/B two helix domain AS54_4483 ENOG4108IYU L-aspartate oxidase AS54_4486 ENOG4108RPX mosc domain containing protein AS54_4487 ENOG4105CQC Prephenate dehydratase AS54_4491 ENOG4105EWM Histidine kinase AS54_4496 ENOG4105X36 (ribosomal) protein AS54_4498 ENOG4105C03 ribonuclease AS54_4501 ENOG4107QMS site-determining protein AS54_4504 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AS54_4505 ENOG4105DFF Rod shape-determining protein mreb AS54_4509 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AS54_4510 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AS54_4512 ENOG41068KH stage VI sporulation protein D AS54_4514 ENOG4105D52 delta-aminolevulinic acid dehydratase AS54_4519 ENOG4105K56 Transcriptional regulator AS54_452 ENOG4105CBD Diacylglycerol kinase AS54_4523 ENOG4108IUQ atp-dependent protease AS54_453 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AS54_4530 ENOG4108QCI YvbH-like oligomerisation region AS54_4533 ENOG4105M59 Phosphodiesterase, mj0936 family AS54_4534 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AS54_4536 ENOG4108XJQ germination protein AS54_4538 ENOG4108PCX Major Facilitator AS54_454 ENOG4108JPW Aminotransferase AS54_4540 ENOG4105KBX Transcriptional regulator, TetR family AS54_4543 ENOG4105PFC Transcriptional regulator AS54_4545 ENOG4105DZC cytosine deaminase AS54_4546 ENOG41067S9 phage shock protein C, PspC AS54_4547 ENOG4108JCI Transcriptional regulator AS54_4549 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AS54_4551 ENOG4108Z40 Transcriptional regulator AS54_4552 ENOG4105RHA ABC transporter, permease AS54_4553 ENOG4108IUX (ABC) transporter AS54_4554 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AS54_4555 ENOG4105ER2 Ompa motb domain protein AS54_4556 ENOG4105E14 MotA TolQ exbB proton channel AS54_4557 ENOG4108VXD carboxy-peptidase AS54_4559 ENOG4105E33 succinate dehydrogenase AS54_456 ENOG4105C26 Dehydrogenase AS54_4561 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AS54_4564 ENOG4105K63 Thioredoxin AS54_4565 ENOG4105C10 Electron transfer flavoprotein AS54_4566 ENOG4105BZJ Electron transfer flavoprotein AS54_4567 ENOG41060WC Enoyl-CoA hydratase AS54_4568 ENOG4107Z3H Transcriptional regulator, TetR family AS54_4569 ENOG4105CEY Amp-dependent synthetase and ligase AS54_457 ENOG4105KPY Small multidrug resistance protein AS54_4571 ENOG4105J76 Periplasmic binding protein AS54_4572 ENOG4105S6R Iron-hydroxamate transporter permease subunit AS54_4580 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS54_4583 ENOG4105DR4 Methyltransferase AS54_4586 ENOG4105KFN sortase, SrtB family AS54_4587 ENOG4105E0A ABC, transporter AS54_4590 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AS54_4591 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AS54_4593 ENOG4105FE9 pseudouridine synthase AS54_4596 ENOG4105DCG PHP domain protein AS54_4603 ENOG4105C5S asparaginyl-tRNA synthetase AS54_4604 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AS54_4606 ENOG4108RWN rrna methyltransferase AS54_461 ENOG4105D9N nucleoside AS54_4615 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS54_4616 ENOG4105CW7 secretion protein, HlyD family AS54_4617 ENOG4108JGH Tetr family transcriptional regulator AS54_4618 ENOG4105CN9 Peptidase m42 family protein AS54_462 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AS54_4622 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AS54_4623 ENOG4105C22 threonyL-tRNA synthetase AS54_4624 ENOG4108TDW sporulation protein YtxC AS54_4628 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AS54_4629 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AS54_4630 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AS54_4632 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AS54_4633 ENOG4105C2M dna polymerase I AS54_4634 ENOG4105BZU Histidine kinase AS54_4635 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS54_464 ENOG4105BZU Histidine kinase AS54_4640 ENOG4108HMX isocitrate dehydrogenase (NADP) AS54_4641 ENOG4105BZN citrate synthase AS54_4643 ENOG4108REF Sporulation integral membrane protein ytvi AS54_4644 ENOG4105FS0 cytoplasmic membrane protein AS54_4649 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AS54_465 ENOG4108W15 Protein of unknown function (DUF1456) AS54_4650 ENOG4105C6K Malic enzyme AS54_4651 ENOG4105C0B DNA polymerase III (alpha subunit) AS54_4652 ENOG4105VV2 AS54_4654 ENOG4105SFS phosphoesterase RecJ domain protein AS54_4661 ENOG4105DC7 peptidase M24 AS54_4670 ENOG41082W1 Cupin 2, conserved barrel domain protein AS54_4672 ENOG4105VZ8 Transcriptional regulator AS54_4676 ENOG4107YZX Universal stress protein AS54_468 ENOG4105DTQ mandelate racemase muconate lactonizing AS54_4685 ENOG4108JYZ YitT family AS54_4688 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AS54_469 ENOG4105DFD Na H antiporter AS54_4690 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AS54_4691 ENOG4105KBJ sporulation protein ytfj AS54_4694 ENOG4105EFZ amidohydrolase AS54_4696 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AS54_4701 ENOG4106KR7 LysR family Transcriptional regulator AS54_4704 ENOG4105U5Y Transcriptional regulator AS54_4706 ENOG4105C28 cystathionine AS54_4715 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AS54_4718 ENOG4105F1V Acetoin utilization protein AS54_4719 ENOG4105W87 Cbs domain AS54_4720 ENOG4105DGU Histone deacetylase AS54_4723 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS54_4725 ENOG4107SNB ankyrin repeat protein YahD AS54_4726 ENOG4105EP9 oxidoreductase AS54_4732 ENOG4105ETE Transcriptional regulator (LacI family AS54_4736 ENOG4105C88 aminopeptidase AS54_474 ENOG4105D3R alkyl hydroperoxide reductase AS54_4745 ENOG4105K7K Transcriptional regulator AS54_475 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AS54_4751 ENOG4108VDD TRNA binding domain protein AS54_4757 ENOG4105C8F Beta-lactamase domain protein AS54_4760 ENOG4108V15 phosphotransferase enzyme family AS54_4761 ENOG4108IUM Glycogen debranching enzyme AS54_4763 ENOG4107QSE Dipeptidase AS54_4764 ENOG4105YW5 deoR family transcriptional regulator AS54_4767 ENOG4105CBX hi0933 family AS54_477 ENOG4107W7X Aldolase AS54_4774 ENOG4108VJ1 Transcriptional regulator (CarD family AS54_4775 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AS54_4779 ENOG4108ZAF Molybdopterin AS54_478 ENOG4105EHG Permease protein AS54_4780 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AS54_4781 ENOG4105CVM Molybdenum cofactor synthesis domain protein AS54_4783 ENOG4105D06 uba thif-type nad fad binding protein AS54_4784 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AS54_4788 ENOG41085GJ domain protein AS54_479 ENOG4105DQ5 transport system permease protein AS54_4790 ENOG4105DWV Homoserine O-trans-acetylase AS54_4792 ENOG4108B31 Spore germination protein AS54_4798 ENOG410605W Major Facilitator AS54_4799 ENOG4107S91 Sodium hydrogen exchanger AS54_48 ENOG4105CDU Replicative dna helicase AS54_4800 ENOG4105NCW Trka-c domain protein AS54_4804 ENOG4105C19 ABC transporter AS54_4808 ENOG4105N5T Radical SAM Protein AS54_4810 ENOG4105CIG ABC transporter AS54_4816 ENOG4105E8V Alpha Beta Hydrolase Fold protein AS54_4817 ENOG4108Z0R Transferase AS54_4818 ENOG4105YVM Phosphoesterase, PA-phosphatase related AS54_4819 ENOG4105BZF Glycosyl transferase (Group 1 AS54_4821 ENOG4108RIR Molybdenum cofactor biosynthesis protein AS54_4833 ENOG4107XGZ Hydrolase AS54_4834 ENOG4105E98 transcriptional regulator DeoR family AS54_4836 ENOG4105BZU Histidine kinase AS54_4837 ENOG4105BZU Histidine kinase AS54_4838 ENOG4107S9D Alpha beta hydrolase AS54_4839 ENOG4107T7U Sulfatase AS54_484 ENOG4106UIA AS54_4842 ENOG4105D2X ABC transporter substrate-binding protein AS54_4844 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AS54_4847 ENOG4107XGZ Hydrolase AS54_485 ENOG4106UIA AS54_4854 ENOG4108V2W Carbonate dehydratase AS54_4856 ENOG4105C4M (Ubiquinol oxidase) subunit I AS54_4857 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AS54_4866 ENOG41087YS Phage shock protein A AS54_4872 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AS54_4880 ENOG4105N67 Proton-coupled thiamine transporter YuaJ AS54_4881 ENOG4105BZU Histidine kinase AS54_4882 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS54_4887 ENOG4108UGV hypoxanthine phosphoribosyltransferase AS54_4888 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AS54_4889 ENOG4105D7V transposase AS54_4893 ENOG4107ZTW SNARE associated Golgi AS54_4898 ENOG4105C19 ABC transporter AS54_4899 ENOG41086D8 Transcriptional regulator AS54_4907 ENOG4105C6Z Gluconate AS54_4908 ENOG4105FDP GntR family transcriptional regulator AS54_4912 ENOG41069H0 dihydroorotase EC 3.5.2.3 AS54_4916 ENOG4105DTQ mandelate racemase muconate lactonizing AS54_4918 ENOG4108IPT Naphthoate synthase AS54_4919 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AS54_492 ENOG410756H nucleotidyltransferase AS54_4921 ENOG4105E4F Isochorismate synthase AS54_4922 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AS54_4924 ENOG4105VEQ Cold shock protein AS54_493 ENOG4105D2S major facilitator superfamily AS54_4934 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AS54_4935 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AS54_4954 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AS54_496 ENOG4105E5Q amino acid AbC transporter AS54_4962 ENOG4105KT7 mgtC SapB transporter AS54_4964 ENOG4107PBV potassium channel AS54_4966 ENOG4105WG9 Conserved Protein AS54_4968 ENOG4105CHM Aminotransferase AS54_4969 ENOG4108ZB6 transcriptional regulator AsnC family AS54_497 ENOG4105EAB amino acid AbC transporter AS54_4970 ENOG4105C5I Dehydrogenase AS54_4971 ENOG4108MUZ hydrolase AS54_4974 ENOG4105C87 Aminotransferase class I and II AS54_4977 ENOG4105Y38 Kinase-associated protein B AS54_4979 ENOG4107R3E Citrate transporter AS54_4982 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AS54_4983 ENOG4105KA0 thioesterase Superfamily protein AS54_4986 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AS54_499 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AS54_4990 ENOG41069ER domain protein AS54_4993 ENOG4105CEP NADH dehydrogenase AS54_4999 ENOG4105EWC Purine nucleoside phosphorylase AS54_50 ENOG4105BZR domain protein AS54_5001 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AS54_5005 ENOG4108JJA ABC, transporter AS54_5006 ENOG4105C4B ABC transporter, permease AS54_5007 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AS54_501 ENOG4105CI1 PTS System AS54_5012 ENOG41083MR nifu domain-containing protein AS54_5015 ENOG4108W5N phosphatidylglycerophosphatase a AS54_5018 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AS54_5019 ENOG4105DYS nad(p)h dehydrogenase (quinone) AS54_5020 ENOG4105D4U had-superfamily hydrolase, subfamily iia AS54_5023 ENOG4105CBT Fructose-1,6-bisphosphatase AS54_5026 ENOG4105MMD transcriptional regulator AS54_5027 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AS54_5028 ENOG4107TXC Transcriptional regulator AS54_5029 ENOG41090T1 Membrane AS54_5034 ENOG4105FAA peptidase M23 AS54_5036 ENOG4105KZD Domain of unknown function (DUF1805) AS54_5037 ENOG4107R8B 5'-nucleotidase AS54_5040 ENOG4105DIW FeS assembly protein SUFB AS54_5041 ENOG4108UNV SUF system FeS assembly protein, NifU family AS54_5042 ENOG4105C9B Cysteine desulfurase AS54_5043 ENOG4105JRK feS assembly protein SufD AS54_5044 ENOG4105C3K feS assembly ATPase SufC AS54_5045 ENOG4105D01 (LipO)protein AS54_5046 ENOG4105D01 (LipO)protein AS54_5047 ENOG4108UMI ABC transporter, permease AS54_5053 ENOG41080E8 Transcriptional regulator, Spx MgsR family AS54_5062 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AS54_507 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AS54_5070 ENOG4108W8B Beta-lactamase domain protein AS54_5073 ENOG4108IUW ABC transporter AS54_5078 ENOG4105C1G acyl-Coa dehydrogenase AS54_5079 ENOG4105CHU acetyl-coa acetyltransferase AS54_5082 ENOG4105DZ1 carboxypeptidase AS54_5086 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AS54_5090 ENOG4108SUT Major Facilitator Superfamily AS54_5091 ENOG4107R7I amino acid AS54_5094 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AS54_5096 ENOG4107AYK membrAne AS54_51 ENOG4108XMW Membrane AS54_510 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AS54_5104 ENOG4107ZTW SNARE associated Golgi AS54_5106 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AS54_5107 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS54_5108 ENOG4105BZU Histidine kinase AS54_5112 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AS54_5113 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AS54_5114 ENOG4105VG1 fes assembly suf system protein AS54_5115 ENOG4105D4Y metalloprotease AS54_5119 ENOG4107S91 Sodium hydrogen exchanger AS54_5120 ENOG4105NCW Trka-c domain protein AS54_5122 ENOG4108RMU ferritin dps family protein AS54_5125 ENOG4108URH decarboxylase AS54_5129 ENOG4105D9N nucleoside AS54_5130 ENOG4105D9N nucleoside AS54_5131 ENOG4105D9N nucleoside AS54_5134 ENOG4108RYK Nad-dependent epimerase dehydratase AS54_5138 ENOG4105CV8 reductase AS54_5139 ENOG4105F27 Major Facilitator AS54_514 ENOG4105C5H ABC transporter AS54_5140 ENOG4105KVH Transcriptional regulator AS54_5143 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AS54_5144 ENOG4105D4A Cell wall formation (By similarity) AS54_5146 ENOG4105C8Q Methyl-accepting chemotaxis AS54_5148 ENOG4105WMR Protein CrcB homolog AS54_5153 ENOG4105C5H ABC transporter AS54_5154 ENOG4108MK9 spermidine N(1)-acetyltransferase AS54_5155 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AS54_5157 ENOG4108IPW abc transporter atp-binding protein AS54_5158 ENOG4105CM4 permease protein AS54_5163 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AS54_5165 ENOG4105XZU Preprotein translocase, subunit SecG AS54_5177 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS54_5188 ENOG4108C33 Resolvase AS54_5195 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AS54_5198 ENOG41090VF Stage v sporulation protein ac AS54_5199 ENOG4105CZ3 stage V sporulation protein ad AS54_520 ENOG41062JF Transcriptional regulator AS54_5202 ENOG4105H67 Protein of unknown function (DUF421) AS54_5203 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AS54_5204 ENOG4105KRI phosphocarrier protein (HPr AS54_5206 ENOG4105CHW UPF0052 protein AS54_5208 ENOG4108Z4K mutator MutT protein AS54_5210 ENOG4105C3M thioredoxin reductase AS54_5212 ENOG4108S4C acetyltransferase AS54_5216 ENOG41086DT Membrane protein of unknown function AS54_5218 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AS54_5219 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AS54_5222 ENOG4107TXC Transcriptional regulator AS54_5227 ENOG4105HMI Membrane AS54_5228 ENOG4105DUM transcriptional regulator, lysR family AS54_5230 ENOG4108WS4 fmn reductase AS54_5231 ENOG4105C5H ABC transporter AS54_5233 ENOG4105BZ1 (ABC) transporter AS54_5235 ENOG4105CN1 protease AS54_5236 ENOG4105CRP Part of the ABC transporter FtsEX involved in AS54_5237 ENOG4105CAK Cell division ATP-binding protein ftsE AS54_5239 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AS54_524 ENOG4105DEU major facilitator superfamily AS54_5241 ENOG4105MS2 ribosomal subunit Interface protein AS54_5242 ENOG4105VEQ Cold shock protein AS54_5243 ENOG41081UC Inherit from COG: Competence protein AS54_5246 ENOG4105KVH Transcriptional regulator AS54_5248 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AS54_5249 ENOG4108KGH TRANSCRIPTIONal AS54_5250 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AS54_5251 ENOG4105C6Y Udp-glucose 6-dehydrogenase AS54_5252 ENOG4105ESV Glycosyl transferase, family 4 AS54_5254 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AS54_5258 ENOG4105F8D glycoside hydrolase family 4 AS54_5259 ENOG4105VCP PTS System AS54_5260 ENOG4105CK1 PTS System AS54_5262 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AS54_5266 ENOG4105VCP PTS System AS54_5268 ENOG4105VZJ PTS System AS54_5271 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AS54_5275 ENOG4105ECB domain protein AS54_5276 ENOG4107RSM transcriptional regulator AS54_5283 ENOG4105DAA L-lactate AS54_5284 ENOG4105D7V transposase AS54_5286 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AS54_5288 ENOG4105E0M Sulfatase AS54_5293 ENOG4107R8N Glycosyl transferase, family 2 AS54_5295 ENOG4105C94 Transporter AS54_5296 ENOG41069ER domain protein AS54_53 ENOG4108UUM single-stranded DNA-binding protein AS54_530 ENOG4108N0M stress protein AS54_5301 ENOG4105KBK Zinc finger, swim domain protein AS54_5302 ENOG4105C0D helicase AS54_5308 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS54_531 ENOG4106FN3 tellurium resistance protein AS54_5311 ENOG4107RBB ABC transporter, permease AS54_5312 ENOG4105C19 ABC transporter AS54_5316 ENOG4105CXY transporter AS54_532 ENOG4106FN3 tellurium resistance protein AS54_5320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS54_5321 ENOG4105DG6 mannose-6-phosphate isomerase AS54_5322 ENOG4105DM4 PTS System AS54_5324 ENOG4105CMR udp-glucose 4-epimerase AS54_5326 ENOG4108KGH TRANSCRIPTIONal AS54_5327 ENOG4105DG6 mannose-6-phosphate isomerase AS54_5328 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AS54_5329 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AS54_533 ENOG4107TS3 membrane protein, TerC AS54_5330 ENOG4108TJN glycosyl transferase group 1 AS54_5331 ENOG4105C6Y Udp-glucose 6-dehydrogenase AS54_5335 ENOG4105D3Q Sugar transferase AS54_5336 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AS54_5337 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AS54_5338 ENOG4107YJ4 chain length determinant protein AS54_5339 ENOG4105HTX biosynthesis protein AS54_534 ENOG4108TTB tellurium resistance protein AS54_5340 ENOG4107YJ4 chain length determinant protein AS54_5343 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AS54_5344 ENOG4105FRN stage II sporulation protein AS54_5347 ENOG4105DY9 regulatoR AS54_5351 ENOG4106778 Protein of unknown function (DUF1146) AS54_5352 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AS54_5353 ENOG4105C8S subunit m AS54_5354 ENOG4105D65 subunit l AS54_5359 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AS54_5360 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AS54_5362 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AS54_5363 ENOG4105BZU Histidine kinase AS54_5373 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AS54_5374 ENOG41062M3 atp synthase AS54_538 ENOG4105KJF protein tyrosine phosphatase AS54_5381 ENOG4108YZG isomerase AS54_5384 ENOG4108VGI doxx family AS54_5385 ENOG4107XC4 flavin reductase domain protein, FMN-binding AS54_5390 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AS54_5392 ENOG4108ZXQ stage ii sporulation protein r AS54_5393 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AS54_5394 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AS54_5397 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AS54_5398 ENOG4105CBT Fructose-1,6-bisphosphatase AS54_5399 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AS54_540 ENOG4107U9T Pfam:Ribonuclease_BN AS54_5406 ENOG4105C1G acyl-Coa dehydrogenase AS54_5407 ENOG4105C1G acyl-Coa dehydrogenase AS54_5408 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AS54_541 ENOG4105C59 p-type ATPase AS54_5410 ENOG4105DF6 Fe-S oxidoreductase AS54_5413 ENOG4105BZU Histidine kinase AS54_5418 ENOG4105BZU Histidine kinase AS54_5419 ENOG4105KCT ABC transporter AS54_542 ENOG4108IPJ Membrane AS54_5420 ENOG4108M15 ABC transporter AS54_5421 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AS54_5423 ENOG4105IIU Aminopeptidase AS54_5427 ENOG4105EMN RNA polymerase sigma factor AS54_5429 ENOG410684U Domain of unknown function (DUF1934) AS54_5433 ENOG4105CYW agmatinase AS54_5435 ENOG4105DXB Major Facilitator superfamily AS54_5436 ENOG4107SWG transcriptional regulator MERR family AS54_5437 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AS54_5438 ENOG4105BZ4 penicillin-binding protein AS54_5439 ENOG4108XFG YwhD family AS54_5440 ENOG4108Z4T Peptidase M50 AS54_5441 ENOG41069HH 4-oxalocrotonate tautomerase AS54_5442 ENOG4105DCI Phosphohydrolase AS54_5443 ENOG4108MES Periplasmic binding protein AS54_5444 ENOG4105E0A ABC, transporter AS54_5445 ENOG4105EHG Permease protein AS54_5446 ENOG4105DQ5 transport system permease protein AS54_5448 ENOG4108VCI transcription factor, rsfa family AS54_5451 ENOG4108IJ2 phosphate acetyltransferase AS54_5454 ENOG4108VKI Cell wall hydrolase AS54_5458 ENOG4107SVH Potassium channel protein AS54_5460 ENOG410667J hydrolase AS54_5461 ENOG4105VCH membrane AS54_5463 ENOG4108TU7 Inherit from COG: (ABC) transporter AS54_5464 ENOG4105CJ1 ABC, transporter AS54_5465 ENOG41090WU lipolytic protein G-D-S-L family AS54_5468 ENOG4105D6E homoserine dehydrogenase AS54_547 ENOG4107ZTW SNARE associated Golgi AS54_5472 ENOG4108Y4K DNA-binding transcriptional activator AS54_5474 ENOG4105WH1 Two component transcriptional regulator luxr family AS54_5475 ENOG4105BZU Histidine kinase AS54_5476 ENOG4105DWF phosphomethylpyrimidine kinase AS54_5477 ENOG4105BZU Histidine kinase AS54_5478 ENOG4105VCD cytoplasmic protein AS54_5479 ENOG4105D22 carbon starvation protein AS54_5480 ENOG4105DY9 regulatoR AS54_5481 ENOG41079KZ Major Facilitator Superfamily AS54_5488 ENOG4108K8S endonuclease I AS54_55 ENOG4105C3G gtp-binding protein AS54_550 ENOG410606W general stress protein AS54_5508 ENOG4105DQ6 Transposase AS54_551 ENOG4105UPD Calcium Proton AS54_5510 ENOG4105C6Y Udp-glucose 6-dehydrogenase AS54_5511 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AS54_5514 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AS54_5515 ENOG4106AKK s-layer domain-containing protein AS54_5518 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AS54_5519 ENOG4105D7V transposase AS54_5522 ENOG4105DHF Membrane AS54_5573 ENOG4107QZI cell division protein FtsK AS54_5574 ENOG41082BM Transcriptional regulator, arsr family AS54_56 ENOG4105VDK protein, conserved in bacteria AS54_561 ENOG4108JUB Transcriptional regulator AS54_5627 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AS54_563 ENOG4108IQI permease AS54_5630 ENOG4108IBT Inherit from COG: transposase AS54_5635 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AS54_5636 ENOG4107QKA exodeoxyribonuclease V beta AS54_5637 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AS54_5639 ENOG4108MEK Metal-binding protein YodA AS54_5642 ENOG4105DQ6 Transposase AS54_5645 ENOG4105DQ6 Transposase AS54_5647 ENOG4108IBT Inherit from COG: transposase AS54_5655 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AS54_5657 ENOG4105KRN Transcriptional regulator, abrb family AS54_57 ENOG4105D8X mechanosensitive ion channel AS54_571 ENOG4108A04 Beta-lactamase AS54_574 ENOG4105CKK Glycosyl transferase, family 2 AS54_575 ENOG4107QQG Dehydrogenase AS54_576 ENOG4105C3I Nad-dependent epimerase dehydratase AS54_579 ENOG4105F1A Pyruvate formate-lyase AS54_58 ENOG4108ZDA Sporulation protein YyaC AS54_583 ENOG4105CI2 imidazolone-5-propionate hydrolase AS54_584 ENOG4105ECP epimerase AS54_59 ENOG4105FA0 parb-like partition protein AS54_590 ENOG41067AE Membrane-bound metal-dependent hydrolase AS54_591 ENOG4105CEN a g-specific adenine glycosylase AS54_592 ENOG4106BXE AS54_597 ENOG4105BZ1 (ABC) transporter AS54_598 ENOG4107NBY Membrane AS54_599 ENOG4105CBC glutamate synthase AS54_6 ENOG4105JEU Glycosyl transferase, family 2 AS54_60 ENOG4107QJE Chromosome Partitioning Protein AS54_601 ENOG4108IUW ABC transporter AS54_605 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AS54_606 ENOG4105G5W regulator Fur family AS54_630 ENOG4108JQC penicillin-binding protein 1A AS54_631 ENOG4107ZQN disulfide bond AS54_633 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AS54_635 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AS54_636 ENOG4105BZU Histidine kinase AS54_638 ENOG4105CYN Serine protein kinase AS54_641 ENOG4105C94 Transporter AS54_644 ENOG4105DZ6 Band 7 protein AS54_646 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AS54_647 ENOG4108V9W transcriptional regulatory protein AS54_648 ENOG4105D4T Citrate transporter AS54_652 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AS54_653 ENOG4108STX response regulator AS54_654 ENOG4105US7 Histidine kinase AS54_659 ENOG4108MRH transcriptional regulatory protein AS54_66 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AS54_661 ENOG4105C6K Malic enzyme AS54_663 ENOG4108UZ3 Transporter AS54_664 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AS54_666 ENOG4105BZU Histidine kinase AS54_667 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS54_669 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AS54_670 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AS54_671 ENOG4108JB9 formate dehydrogenase AS54_675 ENOG4105CUB amino acid AS54_677 ENOG4105C59 p-type ATPase AS54_678 ENOG4105DAP Nicotinate phosphoribosyltransferase AS54_685 ENOG41073R8 VanW family AS54_686 ENOG4108KGH TRANSCRIPTIONal AS54_687 ENOG4105D9N nucleoside AS54_688 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AS54_689 ENOG4105C37 (CBS) domain AS54_690 ENOG4108IJ0 Aspartate ammonia-lyase AS54_691 ENOG4105DAA L-lactate AS54_696 ENOG4105DUX Transporter AS54_697 ENOG4108MES Periplasmic binding protein AS54_698 ENOG4105DQ5 transport system permease protein AS54_699 ENOG4108IHU transport system permease protein AS54_7 ENOG4105C5H ABC transporter AS54_70 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AS54_700 ENOG4105E0A ABC, transporter AS54_701 ENOG4105DMQ Methyltransferase AS54_703 ENOG4105EXW epimerase dehydratase AS54_704 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AS54_706 ENOG4107T89 von Willebrand factor, type A AS54_707 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AS54_708 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AS54_71 ENOG410848D S4 domain protein YaaA AS54_712 ENOG4105D5Q Arginine ornithine antiporter AS54_713 ENOG4107414 GntR family transcriptional regulator AS54_714 ENOG4105C5Y PTS System AS54_715 ENOG4105CG3 alpha amylase, catalytic region AS54_718 ENOG4105E1K spore germination protein AS54_719 ENOG4108XG2 Histidine kinase AS54_720 ENOG4105WH1 Two component transcriptional regulator luxr family AS54_721 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AS54_724 ENOG4105CRN Aminoglycoside phosphotransferase AS54_725 ENOG4105BZG amino acid carrier protein AS54_726 ENOG4105CDA abc transporter atp-binding protein AS54_727 ENOG4105CT1 (ABC) transporter AS54_728 ENOG4105EAD ABC transporter AS54_729 ENOG4105DRP amino acid AbC transporter AS54_730 ENOG4108IQI permease AS54_735 ENOG4105D29 Helix-turn-helix type 11 domain protein AS54_736 ENOG4105NAE bifunctional deaminase-reductase domain protein AS54_737 ENOG4105BZU Histidine kinase AS54_74 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AS54_740 ENOG4105CHH sulfate transporter AS54_741 ENOG41068KF Universal stress protein AS54_743 ENOG4105DEF Extracellular solute-binding protein, family 5 AS54_745 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AS54_746 ENOG4108JQ7 (ABC) transporter AS54_748 ENOG4105CXY transporter AS54_749 ENOG41067TZ transcriptional regulator, MarR family AS54_750 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS54_751 ENOG4105ETE Transcriptional regulator (LacI family AS54_752 ENOG4108RVA ribokinase AS54_754 ENOG4105C2J ABC transporter AS54_755 ENOG4105CNN ABC, transporter AS54_756 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AS54_757 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AS54_769 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AS54_770 ENOG41069ER domain protein AS54_771 ENOG4105VZ8 Transcriptional regulator AS54_772 ENOG4107D63 AS54_774 ENOG4105DUX Transporter AS54_779 ENOG4105C85 amino acid AS54_780 ENOG4105C7N Xanthine uracil vitamin C permease AS54_783 ENOG4105MA6 gCN5-related N-acetyltransferase AS54_788 ENOG4105BZ9 Cytochrome C oxidase, subunit I AS54_789 ENOG4105E2S oxidase) subunit II AS54_792 ENOG4106CAD Protein of unknown function (DUF3311) AS54_793 ENOG4105E1V na solute symporter AS54_796 ENOG4108NHD germination protein AS54_797 ENOG4105CE1 Ferrous iron transport protein b AS54_798 ENOG4105CE1 Ferrous iron transport protein b AS54_799 ENOG4105CE1 Ferrous iron transport protein b AS54_800 ENOG4105CVA phosphate AS54_801 ENOG4105C8U phosphate abc transporter AS54_802 ENOG4105E2Z phosphate ABC transporter (Permease AS54_82 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AS54_829 ENOG41080XQ Signal transduction protein with cbs domains AS54_833 ENOG4105ETU transcriptional activator (TenA AS54_835 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AS54_837 ENOG4108VEU Thiamine monophosphate synthase AS54_838 ENOG41080HI glycine oxidase AS54_841 ENOG4105D06 uba thif-type nad fad binding protein AS54_842 ENOG4105DWF phosphomethylpyrimidine kinase AS54_851 ENOG4108INS Transcriptional regulator AS54_856 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AS54_858 ENOG4105C7N Xanthine uracil vitamin C permease AS54_860 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AS54_864 ENOG4105C5Y PTS System AS54_871 ENOG4108B31 Spore germination protein AS54_875 ENOG4107Y03 Nitroreductase AS54_876 ENOG4105ED1 spovr family AS54_877 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AS54_878 ENOG41085GJ domain protein AS54_879 ENOG4105XTG Pfam:DUF156 AS54_880 ENOG4105VFE sira family AS54_881 ENOG4107TPS domain protein AS54_882 ENOG4105VFE sira family AS54_883 ENOG41085GJ domain protein AS54_885 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AS54_886 ENOG41087NI Sulfite exporter TauE/SafE AS54_888 ENOG4108KGH TRANSCRIPTIONal AS54_89 ENOG4105ZMH deoxynucleoside kinase AS54_893 ENOG4105EMD TRANSCRIPTIONal AS54_894 ENOG4105VCP PTS System AS54_895 ENOG4105VZJ PTS System AS54_899 ENOG41069ER domain protein AS54_900 ENOG4107RBB ABC transporter, permease AS54_901 ENOG4105C19 ABC transporter AS54_908 ENOG4105WEF catalase AS54_91 ENOG4105GTG Isochorismatase AS54_915 ENOG4107T5V SNARE associated Golgi AS54_92 ENOG4108Z6B deaminase AS54_922 ENOG4105CUB amino acid AS54_923 ENOG4107RWR Sodium hydrogen exchanger AS54_925 ENOG4106KNT transcriptional regulator AS54_93 ENOG4105C6E dna polymerase iii AS54_934 ENOG4108YXU transcriptional regulator AsnC family AS54_936 ENOG4105KPY Small multidrug resistance protein AS54_937 ENOG4105KPY Small multidrug resistance protein AS54_940 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AS54_941 ENOG4105E5W Transporter AS54_943 ENOG4107RKG DJ-1/PfpI family AS54_944 ENOG4105CH6 catalase AS54_946 ENOG4105D5Q Arginine ornithine antiporter AS54_947 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AS54_949 ENOG4105C26 Dehydrogenase AS54_950 ENOG4105BZ1 (ABC) transporter AS54_951 ENOG4105BZ1 (ABC) transporter AS54_953 ENOG4105DRP amino acid AbC transporter AS54_954 ENOG4105CDA abc transporter atp-binding protein AS54_957 ENOG410839P AS54_964 ENOG4107FQX Alpha-acetolactate decarboxylase AS54_967 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AS54_968 ENOG4105D4P Coproporphyrinogen iii oxidase AS54_97 ENOG41067KS pro-sigma K processing AS54_971 ENOG4105CHH sulfate transporter AS54_980 ENOG4106AKK s-layer domain-containing protein AS54_982 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AS54_984 ENOG4105CGU Enoyl-CoA hydratase AS54_988 ENOG4105DER m42 family AS54_992 ENOG4105CTU Proline racemase AS54_997 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS54_999 ENOG4108JQ7 (ABC) transporter