locus-tag class description AK40_10 ENOG4105E98 transcriptional regulator DeoR family AK40_100 ENOG4105E0M Sulfatase AK40_1001 ENOG4108D32 Methyltransferase AK40_1007 ENOG41081I9 integral membrane protein AK40_1010 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AK40_1012 ENOG4105EYF MMPL domain protein AK40_1017 ENOG4105WCN acetyltransferase AK40_102 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AK40_1023 ENOG4105C1Q protoporphyrinogen oxidase AK40_1025 ENOG41089UC methyltransferase, type 11 AK40_1026 ENOG41068WN AK40_1028 ENOG4105VEQ Cold shock protein AK40_1033 ENOG4107V2S Transcriptional regulator AK40_1034 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AK40_1037 ENOG4105DND Transcriptional regulator AK40_1038 ENOG4108RPX mosc domain containing protein AK40_1041 ENOG4105BZ1 (ABC) transporter AK40_1042 ENOG4105BZ1 (ABC) transporter AK40_1045 ENOG4105N14 lysine exporter protein LysE YggA AK40_1046 ENOG4108JCI Transcriptional regulator AK40_1053 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AK40_1056 ENOG4108KPJ rna polymerase sigma factor AK40_106 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AK40_1061 ENOG4105F32 YngK protein AK40_1066 ENOG4105RD7 BadF BadG BcrA BcrD AK40_1068 ENOG4107STF Involved in phosphonate degradation (By similarity) AK40_107 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AK40_1073 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AK40_1076 ENOG4105C1J atp-dependent rna helicase AK40_1078 ENOG4108RZE Tetr family transcriptional regulator AK40_1083 ENOG41088CC tellurite resistance protein tehB AK40_1085 ENOG4107RA9 decarboxylase AK40_1086 ENOG4105VTR Integrase AK40_109 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AK40_110 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AK40_1100 ENOG4107RA9 decarboxylase AK40_1102 ENOG41090HR transcriptional regulator AK40_1109 ENOG4105CIN aminoacyl-histidine dipeptidase AK40_111 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AK40_1112 ENOG4105EQK -acetyltransferase AK40_1115 ENOG4107RVG penicillin-binding protein AK40_1118 ENOG4107RF6 penicillin-binding protein AK40_1119 ENOG4107RF6 penicillin-binding protein AK40_112 ENOG4105C8J )-transporter AK40_1122 ENOG4105ETE Transcriptional regulator (LacI family AK40_1123 ENOG4105IE8 Alpha-ketoglutarate permease AK40_1124 ENOG4105CK5 oxidoreductase AK40_1129 ENOG4105D2N Aldolase AK40_1130 ENOG4105DH8 myo-inositol catabolism AK40_1135 ENOG4105CGH 5'-nucleotidase AK40_1137 ENOG4107JM4 Tetratricopeptide repeat AK40_1138 ENOG4105VZ8 Transcriptional regulator AK40_1141 ENOG4108VXD carboxy-peptidase AK40_1144 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity AK40_1145 ENOG41067SE Tetr family transcriptional regulator AK40_1146 ENOG4105C5H ABC transporter AK40_1147 ENOG4105BZU Histidine kinase AK40_1150 ENOG4105CEP NADH dehydrogenase AK40_1151 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AK40_1155 ENOG4105C1G acyl-Coa dehydrogenase AK40_1156 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AK40_1157 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AK40_1158 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AK40_1159 ENOG4105E39 Enoyl-CoA hydratase AK40_116 ENOG4105DFD Na H antiporter AK40_1160 ENOG4107QX3 carboxylase AK40_1161 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AK40_1164 ENOG4105DBI uridine monophosphokinase AK40_1171 ENOG4105T9C HD domain AK40_1172 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AK40_1180 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AK40_1180 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AK40_1187 ENOG41089UC methyltransferase, type 11 AK40_1190 ENOG4105CUV Homoserine Kinase AK40_120 ENOG4105ENE Histidine kinase AK40_1203 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein AK40_1205 ENOG4105DK7 lysyl-tRNA synthetase AK40_121 ENOG4105WH1 Two component transcriptional regulator luxr family AK40_1222 ENOG4105ETU transcriptional activator (TenA AK40_1246 ENOG410667J hydrolase AK40_1247 ENOG4105BZU Histidine kinase AK40_1248 ENOG4107RF6 penicillin-binding protein AK40_125 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AK40_1255 ENOG4108HGU Histidine kinase AK40_1257 ENOG4105RHY Pfam:UPF0157 AK40_1258 ENOG4105CB2 alcohol dehydrogenase AK40_1259 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AK40_1260 ENOG4105CJN penicillin-binding protein AK40_1261 ENOG4108IG5 Transcriptional regulator AK40_1262 ENOG4105CHR reductase AK40_1264 ENOG4105FQP Beta-lactamase AK40_1271 ENOG4108V4B ThiJ pfpI AK40_1276 ENOG4107Y80 Major Facilitator superfamily AK40_1280 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AK40_1285 ENOG4107Y9U Membrane AK40_1292 ENOG4105FCD Major Facilitator AK40_1293 ENOG4105E09 nadh pyrophosphatase AK40_1294 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AK40_1295 ENOG4108Z4K mutator MutT protein AK40_13 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AK40_1300 ENOG4107TB6 phosphoglycerate mutase AK40_1301 ENOG4108XI2 Domain of unknown function (DUF1963) AK40_1306 ENOG4108NRW Phospholipase, patatin family AK40_1307 ENOG4105KWG Pfam:DUF1696 AK40_1314 ENOG4105PKS Excinuclease abc c subunit domain protein AK40_1321 ENOG4107VFR oxidoreductase AK40_1326 ENOG4105PAD Hydrolase AK40_1330 ENOG4108IUM Glycogen debranching enzyme AK40_1336 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AK40_1337 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AK40_1339 ENOG4105FDR Membrane AK40_134 ENOG4105CJ3 phosphate transporter AK40_135 ENOG4107GRR phosphate transport regulator AK40_1350 ENOG4105MSI germination protein ypeb AK40_1357 ENOG4107Z3H Transcriptional regulator, TetR family AK40_136 ENOG4105BZ4 penicillin-binding protein AK40_1362 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AK40_1365 ENOG4108MK9 spermidine N(1)-acetyltransferase AK40_1366 ENOG4105E98 transcriptional regulator DeoR family AK40_1370 ENOG41062ES Transcriptional regulator AK40_1374 ENOG4107QKR Dehydrogenase AK40_1376 ENOG4107RUY (E1 component), alpha subunit AK40_1378 ENOG4105E1F short-chain dehydrogenase reductase AK40_1379 ENOG4105RHY Pfam:UPF0157 AK40_1380 ENOG4105DBI uridine monophosphokinase AK40_1382 ENOG4105M6F mutator MutT protein AK40_1387 ENOG4107SQ8 Glycine betaine AK40_1388 ENOG4108IJ7 Glycine betaine AK40_139 ENOG4105BZU Histidine kinase AK40_1393 ENOG4105E66 phosphoriboisomerase A AK40_1394 ENOG41082BV acetyltransferase AK40_1395 ENOG4108M1A Chitin-binding protein AK40_1398 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AK40_1399 ENOG4105MSB protein, conserved in bacteria AK40_140 ENOG4105I3N Conserved Protein AK40_1400 ENOG4107YB6 acetyltransferase, (GNAT) family AK40_1401 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AK40_1407 ENOG4108Z7F N-acetyltransferase AK40_1411 ENOG4105EEM helicase AK40_1415 ENOG4105C9U ATP-dependent DNA helicase RecQ AK40_1424 ENOG4108M1A Chitin-binding protein AK40_1427 ENOG4105BZG amino acid carrier protein AK40_1428 ENOG4105C26 Dehydrogenase AK40_1429 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AK40_143 ENOG4105BZU Histidine kinase AK40_1430 ENOG4105CTU Proline racemase AK40_1431 ENOG4105CTU Proline racemase AK40_1432 ENOG41080HI glycine oxidase AK40_1434 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein AK40_1440 ENOG4107T5V SNARE associated Golgi AK40_1443 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AK40_1444 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AK40_1447 ENOG4105DTQ mandelate racemase muconate lactonizing AK40_1456 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AK40_1457 ENOG4105BZU Histidine kinase AK40_1458 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK40_1464 ENOG4105DPN Oligoendopeptidase f AK40_1465 ENOG4105DVH amino acid AK40_1467 ENOG4105EPR degv family AK40_1478 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AK40_1479 ENOG4106K7D Major facilitator family transporter AK40_1483 ENOG4107BMA Transglycosylase associated protein AK40_1486 ENOG41089UC methyltransferase, type 11 AK40_149 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AK40_1492 ENOG4105CHM Aminotransferase AK40_1495 ENOG4108ZMI UPF0477 protein AK40_1498 ENOG4105DVE abc transporter atp-binding protein AK40_15 ENOG4105PXI polysaccharide deacetylase AK40_150 ENOG4105DZ1 carboxypeptidase AK40_1507 ENOG4105C02 permease AK40_1509 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AK40_151 ENOG4108JIC nucleoside recognition domain protein AK40_1510 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AK40_1511 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AK40_1514 ENOG4105E09 nadh pyrophosphatase AK40_1518 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AK40_153 ENOG4105FE9 pseudouridine synthase AK40_1532 ENOG4108ZCF integral membrane protein AK40_1533 ENOG4105E0M Sulfatase AK40_1534 ENOG4105C5H ABC transporter AK40_1536 ENOG4105EYF MMPL domain protein AK40_1537 ENOG41082JN Transcriptional regulator AK40_1541 ENOG4105CIH Imidazole acetol-phosphate transaminase AK40_1543 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AK40_155 ENOG4107TWT Cytochrome c biogenesis protein AK40_1551 ENOG41069ER domain protein AK40_1553 ENOG4105CY2 Citrate transporter AK40_1554 ENOG4105E39 Enoyl-CoA hydratase AK40_1555 ENOG4105J5T Amp-dependent synthetase and ligase AK40_1556 ENOG4108JUB Transcriptional regulator AK40_156 ENOG4105CRE cytochrome C AK40_1560 ENOG4105D4B ABC, transporter AK40_1561 ENOG4105F5R ABC transporter AK40_1562 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AK40_1564 ENOG4105DKT Transcriptional regulator AK40_1565 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AK40_1567 ENOG41061GT Aldolase AK40_157 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK40_1572 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AK40_1579 ENOG4105II7 pyrroline-5-carboxylate reductase AK40_158 ENOG4105BZU Histidine kinase AK40_1581 ENOG4107258 Transcriptional regulator AK40_1583 ENOG4105E0Y RtcB Protein AK40_1584 ENOG4105ECK Fatty Acid Desaturase AK40_1585 ENOG4105G6Z alkaline phosphatase AK40_1587 ENOG4105VMP Transcriptional regulator AK40_159 ENOG4108WBT adenosyltransferase AK40_1590 ENOG41090T1 Membrane AK40_1592 ENOG4108WCX response regulator AK40_1594 ENOG41068WN AK40_1599 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AK40_160 ENOG41063SB peptidase AK40_1608 ENOG4105CKK Glycosyl transferase, family 2 AK40_1610 ENOG4105C8Y Acetylornithine aminotransferase AK40_1611 ENOG4105CH6 catalase AK40_162 ENOG4108SAX Membrane AK40_1620 ENOG4108TVJ Nitroreductase AK40_1621 ENOG4105FS7 Transcriptional regulator AK40_1628 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AK40_1631 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AK40_1637 ENOG4108XET gCN5-related N-acetyltransferase AK40_1649 ENOG410635A Membrane AK40_165 ENOG4105C9U ATP-dependent DNA helicase RecQ AK40_1650 ENOG4105KNA -acetyltransferase AK40_1651 ENOG4108IQI permease AK40_1653 ENOG4105F1N DNA alkylation repair AK40_166 ENOG4105I7S Abortive infection protein AK40_1660 ENOG4107RF6 penicillin-binding protein AK40_1662 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AK40_1668 ENOG4105P4J Allophanate hydrolase, subunit 1 AK40_1669 ENOG4107258 Transcriptional regulator AK40_1671 ENOG4106N3A copper homeostasis protein cutc AK40_1672 ENOG4108ZRV stage ii sporulation protein p AK40_1673 ENOG4108ZHR arsR family transcriptional regulator AK40_1675 ENOG4105FDT acyl-CoA dehydrogenase AK40_1679 ENOG4105DWD nucleoside recognition domain protein AK40_168 ENOG4107RGJ metallophosphoesterase AK40_1685 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AK40_169 ENOG4107X2D transcriptional regulator, merr family AK40_1699 ENOG4105E2A Dehydrogenase AK40_17 ENOG4105BZU Histidine kinase AK40_170 ENOG4108S6Z Negative regulator of genetic competence AK40_1701 ENOG4108IJ0 Aspartate ammonia-lyase AK40_1702 ENOG4105HDK L-asparaginase AK40_1703 ENOG4108IMY Transcriptional regulator AK40_1706 ENOG4108B31 Spore germination protein AK40_1708 ENOG4105BZU Histidine kinase AK40_1713 ENOG41075H3 AraC family transcriptional regulator AK40_1714 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AK40_1715 ENOG4105CUB amino acid AK40_1716 ENOG4105II7 pyrroline-5-carboxylate reductase AK40_1719 ENOG4105CSV Glutaminase AK40_1728 ENOG4105CGH 5'-nucleotidase AK40_1729 ENOG41061CK Antibiotic biosynthesis monooxygenase AK40_1739 ENOG4108606 TspO/MBR family AK40_1740 ENOG4105CVP deoxyribo-dipyrimidine photolyase AK40_175 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AK40_1750 ENOG4105F2M alpha beta hydrolase fold-3 domain protein AK40_1753 ENOG4108TWJ NADH dehydrogenase subunit 5 AK40_1754 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AK40_1757 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AK40_1758 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AK40_1759 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AK40_176 ENOG4107RB3 L-asparaginase AK40_1762 ENOG4105C19 ABC transporter AK40_1765 ENOG4108NEV two component transcriptional regulator, LytTR family AK40_1766 ENOG4105DSE periplasmic solute binding protein AK40_1767 ENOG4105CC5 ABC transporter AK40_1768 ENOG4105DIK (ABC) transporter AK40_1773 ENOG4105D6J arsenicaL-resistance protein AK40_1774 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AK40_1775 ENOG41085FC arsR family transcriptional regulator AK40_1779 ENOG4105F7F Chaperone AK40_1787 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AK40_1788 ENOG4105C0R drug resistance transporter emrb qaca subfamily AK40_1790 ENOG4105IIP Membrane AK40_1793 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK40_1794 ENOG41062D9 Histidine kinase AK40_1799 ENOG4105K6H D-cysteine desulfhydrase AK40_18 ENOG41090MY MarR family Transcriptional regulator AK40_1804 ENOG4108NNI Beta-lactamase domain-containing protein AK40_1805 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AK40_1807 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AK40_1810 ENOG4105C88 aminopeptidase AK40_1812 ENOG4105W1Y Transcriptional regulator AK40_1813 ENOG4105JQZ Methyltransferase AK40_1817 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AK40_1820 ENOG4105BZU Histidine kinase AK40_1823 ENOG4108U05 Transcriptional regulator AK40_1824 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 AK40_1826 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AK40_1829 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AK40_183 ENOG4105S2F AK40_1832 ENOG4105CEP NADH dehydrogenase AK40_1833 ENOG4105D4Y metalloprotease AK40_1834 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AK40_184 ENOG41065D1 AK40_1843 ENOG4105TRI Hydrolase AK40_1851 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AK40_1859 ENOG4108FPN Integrase AK40_1863 ENOG4105C44 Serine transporter AK40_1864 ENOG4105EJQ L-serine dehydratase AK40_1866 ENOG4105MZU cell filamentation protein AK40_1867 ENOG4108JPW Aminotransferase AK40_1870 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AK40_1872 ENOG4105DVH amino acid AK40_1876 ENOG4108JQ1 Dehydrogenase AK40_1880 ENOG41082W1 Cupin 2, conserved barrel domain protein AK40_1881 ENOG410874W AraC family transcriptional regulator AK40_1884 ENOG4108IBT Inherit from COG: transposase AK40_1887 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AK40_1895 ENOG4108ISG Major Facilitator AK40_1897 ENOG4107MII Sugar-specific transcriptional regulator TrmB AK40_1898 ENOG4105CZM Major Facilitator AK40_190 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AK40_1902 ENOG4105DA5 (ABC) transporter AK40_1903 ENOG41069JR AK40_1905 ENOG4105RXJ AK40_1906 ENOG4105KPY Small multidrug resistance protein AK40_1907 ENOG4105KBX Transcriptional regulator, TetR family AK40_1908 ENOG4107AUC AK40_1910 ENOG4105CRW Short chain fatty acid transporter AK40_1912 ENOG4105DYS nad(p)h dehydrogenase (quinone) AK40_1919 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AK40_1928 ENOG4107TXC Transcriptional regulator AK40_193 ENOG4105XXQ heptaprenyl diphosphate synthase component I AK40_1932 ENOG4105DSE periplasmic solute binding protein AK40_1933 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AK40_1936 ENOG4108Z66 YbaK ebsC protein AK40_1938 ENOG4105WH1 Two component transcriptional regulator luxr family AK40_1942 ENOG4105KVH Transcriptional regulator AK40_1943 ENOG4108RCM Nitroreductase AK40_1947 ENOG4108PSK reductase AK40_1949 ENOG4105CJ1 ABC, transporter AK40_195 ENOG4105EAH synthase AK40_1955 ENOG4105D7V transposase AK40_1962 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AK40_1963 ENOG4105DKQ ROK family AK40_1964 ENOG4106UW1 Major Facilitator superfamily AK40_1965 ENOG4108UW5 maltose o-acetyltransferase AK40_1967 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AK40_1969 ENOG4105C31 Tryptophanyl-tRNA synthetase AK40_1975 ENOG4105DMQ Methyltransferase AK40_1977 ENOG4105EV4 Multidrug resistance protein mdtH AK40_1983 ENOG4105C37 (CBS) domain AK40_1986 ENOG4105DDN Pentapeptide repeat-containing protein AK40_1987 ENOG4105XDF Protein of unknown function (DUF1272) AK40_1988 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AK40_1989 ENOG4105CMG Carbohydrate kinase AK40_199 ENOG4105CIH Imidazole acetol-phosphate transaminase AK40_1990 ENOG4105C6Z Gluconate AK40_1991 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AK40_1994 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AK40_1998 ENOG4105C44 Serine transporter AK40_20 ENOG4106DF1 AK40_200 ENOG41068YB TPR repeat-containing protein AK40_2004 ENOG4108TZY GntR Family Transcriptional Regulator AK40_2005 ENOG4105D9R oxidoreductase AK40_2012 ENOG4105JAB phenazine biosynthesis protein, phzf family AK40_2014 ENOG4105CHR reductase AK40_2016 ENOG4105KNA -acetyltransferase AK40_2018 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AK40_2019 ENOG4105KVH Transcriptional regulator AK40_2023 ENOG4108ZJ4 polysaccharide deacetylase AK40_203 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AK40_2031 ENOG4105KAF membrAne AK40_204 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AK40_2040 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AK40_2044 ENOG4107YXZ hydrolase, family 25 AK40_205 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AK40_2051 ENOG4105H3G oxidoreductase AK40_2065 ENOG4108TN2 lmbE family AK40_2067 ENOG4107R3E Citrate transporter AK40_2070 ENOG4108MES Periplasmic binding protein AK40_2071 ENOG4105EHG Permease protein AK40_2072 ENOG4105DQ5 transport system permease protein AK40_2073 ENOG4105NX3 Membrane AK40_2074 ENOG4107ZY0 Phenazine biosynthesis-like protein AK40_2078 ENOG4107V2S Transcriptional regulator AK40_2082 ENOG4105C98 muts2 protein AK40_2086 ENOG4105E5K Alpha-amylase AK40_2087 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AK40_2088 ENOG4105DPN Oligoendopeptidase f AK40_2089 ENOG4108A04 Beta-lactamase AK40_2095 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AK40_2100 ENOG41082BM Transcriptional regulator, arsr family AK40_2101 ENOG4105CIS alcohol dehydrogenase AK40_2106 ENOG4105RHY Pfam:UPF0157 AK40_2108 ENOG4105C09 Bile acid AK40_2109 ENOG4105CQB FAD linked oxidase domain protein AK40_211 ENOG4108JYZ YitT family AK40_2113 ENOG4108UT6 Transferase hexapeptide repeat containing protein AK40_2115 ENOG4105K64 Glycosyl transferase, family 2 AK40_2116 ENOG4105E39 Enoyl-CoA hydratase AK40_2118 ENOG4105KT7 mgtC SapB transporter AK40_212 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AK40_2120 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AK40_2121 ENOG41073R8 VanW family AK40_2123 ENOG4108R1P AK40_2126 ENOG4105VEQ Cold shock protein AK40_2136 ENOG410904N short-chain dehydrogenase reductase AK40_2138 ENOG4106IQC argininosuccinate lyase AK40_2141 ENOG4108IA2 Sodium pantothenate symporter AK40_2143 ENOG4105C26 Dehydrogenase AK40_2144 ENOG4105CHR reductase AK40_2146 ENOG4105EWU Squalene--hopene cyclase AK40_2148 ENOG4105FR1 rard protein AK40_2149 ENOG410696E Membrane AK40_215 ENOG4105FJR Lmbe family AK40_2152 ENOG4105D1F ATP-binding protein AK40_2154 ENOG4108ZAF Molybdopterin AK40_2155 ENOG4105CVM Molybdenum cofactor synthesis domain protein AK40_2156 ENOG4105D06 uba thif-type nad fad binding protein AK40_2157 ENOG4105TMB Formate nitrite transporter AK40_2159 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AK40_216 ENOG4105CPK Glycosyl transferase (Group 1 AK40_2160 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AK40_2162 ENOG4108JB9 formate dehydrogenase AK40_2164 ENOG4105E1K spore germination protein AK40_2176 ENOG4107QJT sodium dicarboxylate symporter AK40_2177 ENOG4108KGH TRANSCRIPTIONal AK40_2179 ENOG4105EMN RNA polymerase sigma factor AK40_2183 ENOG4105CIG ABC transporter AK40_2185 ENOG4105D9R oxidoreductase AK40_2188 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AK40_2189 ENOG4105K4P CoA-binding domain protein AK40_2190 ENOG4105C0H protease AK40_2191 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK40_2192 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) AK40_2193 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AK40_2195 ENOG4105W8X HesB YadR YfhF-family protein AK40_22 ENOG4105BZU Histidine kinase AK40_2201 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AK40_2202 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AK40_2204 ENOG4105BZ1 (ABC) transporter AK40_2205 ENOG4108FPN Integrase AK40_2206 ENOG4108KU9 integrase family AK40_2210 ENOG4108I0Z Aconitate hydratase AK40_2216 ENOG4105E5W Transporter AK40_2218 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AK40_2222 ENOG4107F3J Amp-dependent synthetase and ligase AK40_2223 ENOG4107ZYJ bioY protein AK40_2224 ENOG4105CEY Amp-dependent synthetase and ligase AK40_223 ENOG4105DVT helicase AK40_2234 ENOG4107AYK membrAne AK40_2236 ENOG4105BZU Histidine kinase AK40_2237 ENOG4105FBA Phospholipase Carboxylesterase AK40_2238 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AK40_2239 ENOG4105CK7 Sodium proline symporter AK40_224 ENOG4105YAC AK40_2240 ENOG4105CBC glutamate synthase AK40_2241 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AK40_2242 ENOG4108VJ1 Transcriptional regulator (CarD family AK40_2243 ENOG4108903 Formimidoylglutamase AK40_2248 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AK40_2257 ENOG4107QIV Cytochrome c biogenesis protein AK40_2259 ENOG4105CH2 amidohydrolase AK40_2261 ENOG4105CJ1 ABC, transporter AK40_2263 ENOG4107RSM transcriptional regulator AK40_2265 ENOG41067MG lrgb family AK40_2271 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AK40_2274 ENOG4105BZ1 (ABC) transporter AK40_2275 ENOG4105BZ1 (ABC) transporter AK40_228 ENOG4105CSM endonuclease III AK40_2283 ENOG4105CGH 5'-nucleotidase AK40_2285 ENOG4108SVB resolvase AK40_2289 ENOG4105K7K Transcriptional regulator AK40_2290 ENOG4105C5F glutamine synthetase AK40_2291 ENOG4105KV4 Transcriptional regulator AK40_2292 ENOG4105CXI aluminum resistance protein AK40_2293 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AK40_2294 ENOG4105EN6 Membrane AK40_2296 ENOG4106F1P AAA ATPase, central domain protein AK40_230 ENOG4105BZ4 penicillin-binding protein AK40_2302 ENOG41069ER domain protein AK40_2303 ENOG4105DM4 PTS System AK40_2304 ENOG4105DE4 1-phosphofructokinase AK40_2305 ENOG4105E98 transcriptional regulator DeoR family AK40_2306 ENOG4107QW4 alcohol dehydrogenase AK40_2307 ENOG4108SJC Membrane AK40_2310 ENOG4105C85 amino acid AK40_2314 ENOG4105TMB Formate nitrite transporter AK40_2315 ENOG4105K70 DNA-binding protein AK40_2316 ENOG4105C59 p-type ATPase AK40_2317 ENOG410681U heavy metal transport detoxification protein AK40_2318 ENOG4105VPX protein, conserved in bacteria AK40_2320 ENOG4105NIV Esterase AK40_2321 ENOG4105E0A ABC, transporter AK40_2325 ENOG4105CGK Exodeoxyribonuclease III AK40_2327 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AK40_2328 ENOG4105D03 DNA-3-methyladenine glycosylase II AK40_2334 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AK40_2335 ENOG4105BZU Histidine kinase AK40_2349 ENOG4105F0V Cell wall hydrolase AK40_2352 ENOG4105E0M Sulfatase AK40_2353 ENOG410890F Dynamin family AK40_2355 ENOG4107QHE Choloylglycine hydrolase AK40_2361 ENOG4105DQU oxidoreductase, subunit beta AK40_2362 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AK40_2363 ENOG4108IGT Dipeptidase AK40_2364 ENOG4105MCT stage V sporulation protein S AK40_2365 ENOG4105D48 metallophosphoesterase AK40_2370 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AK40_2373 ENOG4105XZV Protein of unknown function (DUF3243) AK40_2374 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AK40_2378 ENOG4105UIB (ABC) transporter AK40_2379 ENOG4108JQ9 ABC transporter AK40_2380 ENOG4105DIH basic membrane AK40_2381 ENOG4105FDP GntR family transcriptional regulator AK40_2382 ENOG4107QZI cell division protein FtsK AK40_2384 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AK40_2386 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AK40_2388 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AK40_2389 ENOG4108S0H Dipicolinic acid synthetase, b subunit AK40_2390 ENOG4105E35 Dipicolinate synthase subunit A AK40_2392 ENOG4105C1V Peptidase, M16 AK40_2396 ENOG4105DTN riboflavin biosynthesis protein ribF AK40_2399 ENOG4105W7A Protein of unknown function (DUF503) AK40_24 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AK40_2401 ENOG4105VHM ribosomal protein AK40_2402 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AK40_2403 ENOG4105CHV Transcription elongation factor NusA AK40_2405 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AK40_2406 ENOG4105EKQ RNA-directed DNA polymerase AK40_2408 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AK40_241 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AK40_2410 ENOG4105DZP Membrane-associated zinc metalloprotease AK40_2411 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AK40_2412 ENOG4105KNE Phosphatidate cytidylyltransferase AK40_2421 ENOG4108HE4 integrase family AK40_2423 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AK40_2424 ENOG4105C79 DNA protecting protein DprA AK40_2425 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AK40_2428 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AK40_243 ENOG4105DVT helicase AK40_2433 ENOG4105VB6 UPF0109 protein AK40_2437 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AK40_2438 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AK40_244 ENOG4105CTD carboxy-peptidase AK40_2441 ENOG4105CHR reductase AK40_2442 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AK40_2445 ENOG4105CB5 ATP-dependent DNA helicase recG AK40_2446 ENOG4105DP4 dak2 domain fusion protein ylov AK40_2447 ENOG4108ZAA Alkaline-shock protein AK40_2449 ENOG4105FJ0 thiamine AK40_2450 ENOG4105DJV ribulose-phosphate 3-epimerase AK40_2451 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AK40_2452 ENOG4105D9P serine threonine protein kinase AK40_2453 ENOG4108ZF3 Phosphatase AK40_2455 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AK40_2457 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AK40_2458 ENOG4105C25 Primosomal protein n' AK40_2459 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AK40_2463 ENOG4105DSJ YicC domain protein AK40_2465 ENOG4105F23 Fibronectin-binding protein AK40_2466 ENOG4105DC7 peptidase M24 AK40_247 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AK40_2478 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AK40_2483 ENOG4105C34 Pseudouridine synthase AK40_2488 ENOG4105DBK s4 domain protein AK40_2489 ENOG41067XK integral membrane protein AK40_249 ENOG4105C2W permease AK40_2491 ENOG4105DFA alanine racemase domain protein AK40_2492 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AK40_2493 ENOG4105WR5 sporulation protein, YlmC YmxH family AK40_2495 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK40_2497 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AK40_2498 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AK40_2499 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AK40_25 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AK40_250 ENOG4105DHF Membrane AK40_2500 ENOG4105D4A Cell wall formation (By similarity) AK40_2501 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AK40_2502 ENOG4105CNI cell division protein FtsW AK40_2505 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AK40_2506 ENOG4105CJN penicillin-binding protein AK40_2507 ENOG4105CJN penicillin-binding protein AK40_2508 ENOG41068DC Essential cell division protein (By similarity) AK40_2515 ENOG4105KNH Nucleic acid-binding protein AK40_2517 ENOG41063PX domain protein AK40_2518 ENOG4105D78 K07001 NTE family protein AK40_252 ENOG410890F Dynamin family AK40_2520 ENOG4105H20 Sporulation integral membrane protein YlbJ AK40_2521 ENOG4106H78 methyltransferase AK40_2525 ENOG4107TB6 phosphoglycerate mutase AK40_2528 ENOG4106UY4 Inherit from COG: Scp-like extracellular AK40_2538 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AK40_2539 ENOG4105CNI cell division protein FtsW AK40_254 ENOG4108W0I acetyltransferase AK40_2542 ENOG4108IAB Phoh family AK40_2546 ENOG4105QA2 AK40_2547 ENOG4105CI3 gtp-binding protein typa AK40_2549 ENOG4105ECY inositol monophosphatase AK40_2553 ENOG4105CXN decarboxylase AK40_256 ENOG4105KHC sulfurtransferase AK40_2563 ENOG4105CPP Dehydrogenase, E1 component AK40_2566 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AK40_2567 ENOG4108X4Q Hydrolase AK40_2569 ENOG4105CN5 Metallo-Beta-Lactamase AK40_2570 ENOG4107ZYR domain protein AK40_2577 ENOG4108XRC Protein of unknown function (DUF458) AK40_2579 ENOG4107IN1 Protein of unknown function (DUF1797) AK40_2582 ENOG4105EPM Diguanylate phosphodiesterase AK40_2583 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AK40_2586 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AK40_2588 ENOG4105UIN AK40_2599 ENOG4108HGU Histidine kinase AK40_260 ENOG4106032 Glutathionylspermidine synthase AK40_2601 ENOG4105CHM Aminotransferase AK40_2602 ENOG4105FKQ transcriptional regulator AK40_2603 ENOG4105EG2 ABC transporter, permease AK40_2605 ENOG4107FKK extracellular solute-binding protein family 1 AK40_2607 ENOG4105CG3 alpha amylase, catalytic region AK40_2617 ENOG4105CHU acetyl-coa acetyltransferase AK40_2623 ENOG4105K7K Transcriptional regulator AK40_2624 ENOG4105DTD Dehydrogenase AK40_2628 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AK40_2636 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AK40_2637 ENOG4106TD9 Diguanylate cyclase AK40_2641 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AK40_2644 ENOG4105CID antiterminator AK40_2646 ENOG4105FDP GntR family transcriptional regulator AK40_2648 ENOG4105CE4 GlcNAc 6-P deacetylase AK40_2655 ENOG4107ZE5 PPIases accelerate the folding of proteins AK40_2656 ENOG4105PTM secreted protein AK40_2657 ENOG4105J7I hydrolase AK40_2659 ENOG4105G6R Stage v sporulation protein ae AK40_266 ENOG4108SZE gCN5-related N-acetyltransferase AK40_2661 ENOG4105CZ3 stage V sporulation protein ad AK40_2662 ENOG41090VF Stage v sporulation protein ac AK40_2666 ENOG4105C8J )-transporter AK40_2667 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK40_2669 ENOG41082AN stage II sporulation protein AK40_2670 ENOG4105DZ1 carboxypeptidase AK40_2671 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AK40_2672 ENOG4105DVE abc transporter atp-binding protein AK40_2678 ENOG4105D7N magnesium and cobalt transport protein CorA AK40_2683 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AK40_2685 ENOG4105I3K Ferric uptake regulator, Fur family AK40_2686 ENOG4105MZ9 stage II sporulation protein m AK40_2690 ENOG4105CPC Aldo Keto reductase AK40_2692 ENOG4105RHY Pfam:UPF0157 AK40_2696 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AK40_2698 ENOG4105ETE Transcriptional regulator (LacI family AK40_2699 ENOG4108YM7 Gcn5-related n-acetyltransferase AK40_270 ENOG41081VK Ribonuclease AK40_2703 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AK40_2704 ENOG4108R6K riboflavin synthase, subunit alpha AK40_2709 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AK40_2710 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AK40_2713 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AK40_2715 ENOG4105DFD Na H antiporter AK40_2716 ENOG4105CGH 5'-nucleotidase AK40_2724 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AK40_2727 ENOG4108IXY short-chain dehydrogenase reductase AK40_2728 ENOG41069FQ Metallo-beta-lactamase superfamily AK40_2729 ENOG4105II7 pyrroline-5-carboxylate reductase AK40_2730 ENOG4105EJQ L-serine dehydratase AK40_2734 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AK40_2736 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AK40_2737 ENOG4105D9U N-acetyltransferase AK40_2739 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AK40_2740 ENOG4108QEG Membrane AK40_2741 ENOG4105CDA abc transporter atp-binding protein AK40_2742 ENOG4105E5Q amino acid AbC transporter AK40_2743 ENOG4108HW3 (ABC) transporter AK40_2745 ENOG4105G7B Protein of unknown function (DUF2992) AK40_2746 ENOG4105E09 nadh pyrophosphatase AK40_2748 ENOG4105C7S Dehydrogenase AK40_2749 ENOG4105CPP Dehydrogenase, E1 component AK40_2753 ENOG4107RDP Dehydrogenase AK40_2755 ENOG4108JUB Transcriptional regulator AK40_2757 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AK40_2760 ENOG4107QQR Sporulation AK40_2761 ENOG4105S1Z Stage IV sporulation protein B AK40_2762 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AK40_2764 ENOG4105DX0 Hemolysin A AK40_2766 ENOG4105CTB Polyprenyl synthetase AK40_2771 ENOG4108ZSR alkaline shock protein AK40_2772 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AK40_2777 ENOG410644B Stage III sporulation protein af AK40_2779 ENOG4105KQ4 Stage iii sporulation protein ad AK40_2780 ENOG4108CQH stage III sporulation protein AC AK40_2781 ENOG4105KR5 Stage iii sporulation protein AK40_2782 ENOG4105CD2 stage iii sporulation protein aa AK40_2787 ENOG4105DC7 peptidase M24 AK40_2790 ENOG4105CBJ Metal-dependent enzyme AK40_2791 ENOG4107YBY Hydrolase AK40_2795 ENOG4105K7K Transcriptional regulator AK40_2798 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AK40_2799 ENOG4105WZW rhodanese family AK40_2803 ENOG41080TC multidrug resistance protein AK40_2810 ENOG4105CJ1 ABC, transporter AK40_2811 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AK40_2817 ENOG4105C0D helicase AK40_283 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AK40_2843 ENOG4105C3R Methionine synthase AK40_2845 ENOG4105C28 cystathionine AK40_2846 ENOG4105C28 cystathionine AK40_2849 ENOG4105C5X domain protein AK40_2851 ENOG4105DKQ ROK family AK40_2853 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AK40_2856 ENOG4108UTW Plays a role in the regulation of phosphate uptake AK40_2857 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AK40_2858 ENOG4105E2Z phosphate ABC transporter (Permease AK40_2859 ENOG4105C8U phosphate abc transporter AK40_2860 ENOG4105PWN phosphate abc transporter AK40_2861 ENOG4107RF6 penicillin-binding protein AK40_2863 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AK40_2868 ENOG4105N80 Ferric uptake regulator, Fur family AK40_287 ENOG4108KU9 integrase family AK40_2870 ENOG4105FDK ABC transporter AK40_2871 ENOG4108JYZ YitT family AK40_2872 ENOG41069ZM Protein of unknown function (DUF2624) AK40_2877 ENOG4105EGD dinuclear metal center protein, YbgI family AK40_288 ENOG4108FPN Integrase AK40_2880 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK40_2881 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AK40_2886 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AK40_2887 ENOG4105KG3 cytidine deaminase AK40_2888 ENOG4107YR5 Diacylglycerol kinase AK40_289 ENOG4107RWR Sodium hydrogen exchanger AK40_2890 ENOG4105CTJ Metal Dependent Phosphohydrolase AK40_2891 ENOG4105C9A Phoh family AK40_2893 ENOG41068P3 sporulation protein YqfC AK40_2894 ENOG4105KTH gatB Yqey AK40_2896 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AK40_2897 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AK40_290 ENOG4105CN5 Metallo-Beta-Lactamase AK40_2901 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AK40_2903 ENOG4105CSA Coproporphyrinogen iii oxidase AK40_2904 ENOG4105KVH Transcriptional regulator AK40_2909 ENOG4105TQK DNA polymerase iii, delta' subunit AK40_291 ENOG4108Z5V transcriptional regulator, merr family AK40_2911 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AK40_2912 ENOG4108UK2 deaminase AK40_2913 ENOG4105KQC Competence protein AK40_2915 ENOG4105DXX methyltransferase AK40_2917 ENOG4108WF2 Metal Dependent Phosphohydrolase AK40_2919 ENOG410812S Rna-binding protein AK40_2921 ENOG4105CQW ribosome biogenesis GTPase YqeH AK40_2922 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AK40_2925 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK40_2929 ENOG4108TVJ Nitroreductase AK40_293 ENOG4105H67 Protein of unknown function (DUF421) AK40_2932 ENOG4105G6Z alkaline phosphatase AK40_2934 ENOG4108MUZ hydrolase AK40_294 ENOG41080C8 DUF218 domain AK40_2940 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AK40_2941 ENOG4105MIR Phenylalanine 4-monooxygenase AK40_2943 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AK40_2951 ENOG4105S6R Iron-hydroxamate transporter permease subunit AK40_2952 ENOG4108V5C ABC transporter AK40_2954 ENOG4108EKI Dehydrogenase AK40_2955 ENOG4105C28 cystathionine AK40_2961 ENOG4107XRG penicillin-binding protein AK40_2964 ENOG4105CFP Peptidase U32 AK40_2965 ENOG4105XYU peptidase (U32 family) AK40_2966 ENOG4108VQJ O-methyltransferase AK40_2967 ENOG4105HHA aminodeoxychorismate lyase AK40_2973 ENOG4105C02 permease AK40_2976 ENOG41060CR AK40_2977 ENOG4105C7H Helicase, RecD TraA family AK40_2980 ENOG4105C3J Cysteine desulfurase AK40_2982 ENOG4105D1H recombination factor protein RarA AK40_2983 ENOG4108VCI transcription factor, rsfa family AK40_2984 ENOG4105CUZ uba thif-type nad fad binding protein AK40_2986 ENOG4105CUT histidyl-tRNA synthetase AK40_2989 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AK40_2991 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AK40_2992 ENOG41076HS cation diffusion facilitator family transporter AK40_2993 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AK40_2995 ENOG4105CKP Polysaccharide Biosynthesis Protein AK40_2996 ENOG4108QG2 Membrane AK40_2998 ENOG4105VIE preprotein translocase, subunit YajC AK40_3001 ENOG41061AI Protein of unknown function (DUF2905) AK40_3004 ENOG4108HUF Transporter AK40_3006 ENOG4108IPJ Membrane AK40_3007 ENOG41082BM Transcriptional regulator, arsr family AK40_3012 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AK40_3013 ENOG4108IYU L-aspartate oxidase AK40_3016 ENOG4108RPX mosc domain containing protein AK40_3017 ENOG4105CQC Prephenate dehydratase AK40_3021 ENOG4105EWM Histidine kinase AK40_3026 ENOG4105X36 (ribosomal) protein AK40_3028 ENOG4105C03 ribonuclease AK40_3031 ENOG4107QMS site-determining protein AK40_3034 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AK40_3035 ENOG4105DFF Rod shape-determining protein mreb AK40_305 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AK40_3052 ENOG4105ED2 Beta-lactamase AK40_3059 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AK40_3063 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AK40_3064 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AK40_3066 ENOG41068KH stage VI sporulation protein D AK40_3068 ENOG4105D52 delta-aminolevulinic acid dehydratase AK40_307 ENOG4107R0U MotA TolQ exbB proton channel AK40_3073 ENOG4105K56 Transcriptional regulator AK40_3077 ENOG4108IUQ atp-dependent protease AK40_308 ENOG4105ER2 Ompa motb domain protein AK40_3084 ENOG4108QCI YvbH-like oligomerisation region AK40_3087 ENOG4105M59 Phosphodiesterase, mj0936 family AK40_3088 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AK40_309 ENOG4107YTP response regulator receiver protein AK40_3090 ENOG4108XJQ germination protein AK40_3092 ENOG4108PCX Major Facilitator AK40_3094 ENOG4105KBX Transcriptional regulator, TetR family AK40_3097 ENOG4105PFC Transcriptional regulator AK40_3099 ENOG4105DZC cytosine deaminase AK40_310 ENOG4105CBS Chea signal transduction histidine kinase AK40_3101 ENOG4108JCI Transcriptional regulator AK40_3103 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AK40_3104 ENOG4108Z40 Transcriptional regulator AK40_3105 ENOG4105RHA ABC transporter, permease AK40_3106 ENOG4108IUX (ABC) transporter AK40_3107 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AK40_3108 ENOG4105ER2 Ompa motb domain protein AK40_3109 ENOG4105E14 MotA TolQ exbB proton channel AK40_311 ENOG4105DD5 Flagellar motor switch protein AK40_3110 ENOG4108VXD carboxy-peptidase AK40_3112 ENOG4105E33 succinate dehydrogenase AK40_3114 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AK40_3117 ENOG4105K63 Thioredoxin AK40_3118 ENOG4105C10 Electron transfer flavoprotein AK40_3119 ENOG4105BZJ Electron transfer flavoprotein AK40_3120 ENOG41060WC Enoyl-CoA hydratase AK40_3121 ENOG4107Z3H Transcriptional regulator, TetR family AK40_3122 ENOG4105CEY Amp-dependent synthetase and ligase AK40_3124 ENOG4105J76 Periplasmic binding protein AK40_3125 ENOG4105S6R Iron-hydroxamate transporter permease subunit AK40_3133 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK40_3136 ENOG4105DR4 Methyltransferase AK40_3139 ENOG4105KFN sortase, SrtB family AK40_314 ENOG4105BZU Histidine kinase AK40_3140 ENOG4105E0A ABC, transporter AK40_3143 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AK40_3144 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AK40_3146 ENOG4105FE9 pseudouridine synthase AK40_3149 ENOG4105DCG PHP domain protein AK40_3156 ENOG4105C5S asparaginyl-tRNA synthetase AK40_3157 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AK40_3159 ENOG4108RWN rrna methyltransferase AK40_3168 ENOG4105C0R drug resistance transporter emrb qaca subfamily AK40_3169 ENOG4105CW7 secretion protein, HlyD family AK40_3170 ENOG4108JGH Tetr family transcriptional regulator AK40_3171 ENOG4105CN9 Peptidase m42 family protein AK40_3175 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AK40_3176 ENOG4105C22 threonyL-tRNA synthetase AK40_3177 ENOG4108TDW sporulation protein YtxC AK40_318 ENOG4105E1Q flagellar hook-associated protein AK40_3181 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AK40_3182 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AK40_3183 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AK40_3185 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AK40_3186 ENOG4105C2M dna polymerase I AK40_3187 ENOG4105BZU Histidine kinase AK40_3188 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK40_319 ENOG4105DTJ flagellar hook-associated protein AK40_3193 ENOG4108HMX isocitrate dehydrogenase (NADP) AK40_3194 ENOG4105BZN citrate synthase AK40_3196 ENOG4108REF Sporulation integral membrane protein ytvi AK40_3197 ENOG4105FS0 cytoplasmic membrane protein AK40_320 ENOG4107TPX flagellar hook-associated AK40_3202 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AK40_3203 ENOG4105C6K Malic enzyme AK40_3204 ENOG4105C0B DNA polymerase III (alpha subunit) AK40_3205 ENOG4105VV2 AK40_3207 ENOG4105SFS phosphoesterase RecJ domain protein AK40_3214 ENOG4105DC7 peptidase M24 AK40_3223 ENOG41082W1 Cupin 2, conserved barrel domain protein AK40_3225 ENOG4105VZ8 Transcriptional regulator AK40_3229 ENOG4107YZX Universal stress protein AK40_323 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AK40_3231 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AK40_324 ENOG4108ZC9 flagellar basal-body rod protein flgc AK40_3242 ENOG4108JYZ YitT family AK40_3247 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AK40_3248 ENOG4105KBJ sporulation protein ytfj AK40_325 ENOG41075Z6 flagellar hook-basal body complex protein fliE AK40_3251 ENOG4105EFZ amidohydrolase AK40_3253 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AK40_3258 ENOG4106KR7 LysR family Transcriptional regulator AK40_326 ENOG4107U2N Flagellar M-ring protein AK40_3260 ENOG4105U5Y Transcriptional regulator AK40_3262 ENOG4105C28 cystathionine AK40_327 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AK40_3272 ENOG4105EMN RNA polymerase sigma factor AK40_3276 ENOG4105F1V Acetoin utilization protein AK40_3277 ENOG4105W87 Cbs domain AK40_3278 ENOG4105DGU Histone deacetylase AK40_3281 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK40_3283 ENOG4107SNB ankyrin repeat protein YahD AK40_3284 ENOG4105EP9 oxidoreductase AK40_3290 ENOG4105ETE Transcriptional regulator (LacI family AK40_3294 ENOG4105C88 aminopeptidase AK40_33 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AK40_3303 ENOG4105K7K Transcriptional regulator AK40_3309 ENOG4108VDD TRNA binding domain protein AK40_3315 ENOG4105C8F Beta-lactamase domain protein AK40_3318 ENOG4108V15 phosphotransferase enzyme family AK40_3319 ENOG4108IUM Glycogen debranching enzyme AK40_3321 ENOG4107QSE Dipeptidase AK40_3322 ENOG4105YW5 deoR family transcriptional regulator AK40_3325 ENOG4105CBX hi0933 family AK40_333 ENOG4105BZE flagellar hook protein, FlgE AK40_3332 ENOG4108VJ1 Transcriptional regulator (CarD family AK40_3333 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AK40_3337 ENOG4108ZAF Molybdopterin AK40_3338 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AK40_3339 ENOG4105CVM Molybdenum cofactor synthesis domain protein AK40_3341 ENOG4105D06 uba thif-type nad fad binding protein AK40_3342 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AK40_3346 ENOG41085GJ domain protein AK40_3348 ENOG4105DWV Homoserine O-trans-acetylase AK40_3350 ENOG4108B31 Spore germination protein AK40_3356 ENOG410605W Major Facilitator AK40_3357 ENOG4107S91 Sodium hydrogen exchanger AK40_3358 ENOG4105NCW Trka-c domain protein AK40_336 ENOG4107R88 Chemotaxis protein (CheV) AK40_3362 ENOG4105C19 ABC transporter AK40_3366 ENOG4105N5T Radical SAM Protein AK40_3368 ENOG4105CIG ABC transporter AK40_3377 ENOG4105E8V Alpha Beta Hydrolase Fold protein AK40_3378 ENOG4108Z0R Transferase AK40_3379 ENOG4105YVM Phosphoesterase, PA-phosphatase related AK40_338 ENOG4105I03 Flagellin AK40_3380 ENOG4105BZF Glycosyl transferase (Group 1 AK40_3382 ENOG4108RIR Molybdenum cofactor biosynthesis protein AK40_3394 ENOG4107XGZ Hydrolase AK40_3395 ENOG4105E98 transcriptional regulator DeoR family AK40_3397 ENOG4105BZU Histidine kinase AK40_3398 ENOG4105BZU Histidine kinase AK40_3399 ENOG4107S9D Alpha beta hydrolase AK40_34 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AK40_340 ENOG4105E4C Lytic transglycosylase catalytic AK40_3400 ENOG4107T7U Sulfatase AK40_3403 ENOG4105D2X ABC transporter substrate-binding protein AK40_3405 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AK40_3408 ENOG4107XGZ Hydrolase AK40_3415 ENOG4108V2W Carbonate dehydratase AK40_3417 ENOG4105C4M (Ubiquinol oxidase) subunit I AK40_3418 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AK40_342 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AK40_3427 ENOG41087YS Phage shock protein A AK40_343 ENOG4105DD5 Flagellar motor switch protein AK40_3433 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AK40_3441 ENOG4105N67 Proton-coupled thiamine transporter YuaJ AK40_3442 ENOG4105BZU Histidine kinase AK40_3443 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK40_3448 ENOG4108UGV hypoxanthine phosphoribosyltransferase AK40_3449 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AK40_345 ENOG4105CN7 Flagellar biosynthetic protein FliP AK40_3450 ENOG4105D7V transposase AK40_3454 ENOG4107ZTW SNARE associated Golgi AK40_3457 ENOG4105C19 ABC transporter AK40_3458 ENOG41086D8 Transcriptional regulator AK40_346 ENOG4105VS8 Flagellar biosynthetic protein fliq AK40_3466 ENOG4105C6Z Gluconate AK40_3467 ENOG4105FDP GntR family transcriptional regulator AK40_3471 ENOG41069H0 dihydroorotase EC 3.5.2.3 AK40_3475 ENOG4105DTQ mandelate racemase muconate lactonizing AK40_3477 ENOG4108IPT Naphthoate synthase AK40_3478 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AK40_348 ENOG4105D00 flagellar biosynthetic protein flhB AK40_3480 ENOG4105E4F Isochorismate synthase AK40_3481 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AK40_3483 ENOG4105VEQ Cold shock protein AK40_349 ENOG4105D7B Flagellar biosynthesis protein flha AK40_3493 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AK40_3494 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AK40_35 ENOG41079K6 HNH endonuclease AK40_350 ENOG4105FZW flagellar biosynthesis regulator FlhF AK40_351 ENOG4105KTQ flagellar basal-body rod protein AK40_3513 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AK40_352 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AK40_3534 ENOG4105KT7 mgtC SapB transporter AK40_3536 ENOG4107PBV potassium channel AK40_3538 ENOG4105WG9 Conserved Protein AK40_3540 ENOG4105CHM Aminotransferase AK40_3541 ENOG4108ZB6 transcriptional regulator AsnC family AK40_3542 ENOG4105C5I Dehydrogenase AK40_3543 ENOG4108MUZ hydrolase AK40_3545 ENOG4105C87 Aminotransferase class I and II AK40_3548 ENOG4105Y38 Kinase-associated protein B AK40_3550 ENOG4107R3E Citrate transporter AK40_3553 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AK40_3554 ENOG4105KA0 thioesterase Superfamily protein AK40_3557 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AK40_3561 ENOG41069ER domain protein AK40_3564 ENOG4105CEP NADH dehydrogenase AK40_3571 ENOG4105EWC Purine nucleoside phosphorylase AK40_3573 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AK40_3577 ENOG4108JJA ABC, transporter AK40_3578 ENOG4105C4B ABC transporter, permease AK40_3579 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AK40_3584 ENOG41083MR nifu domain-containing protein AK40_3587 ENOG4108W5N phosphatidylglycerophosphatase a AK40_359 ENOG4105KAC Antibiotic biosynthesis monooxygenase AK40_3590 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AK40_3591 ENOG4105DYS nad(p)h dehydrogenase (quinone) AK40_3593 ENOG4105D4U had-superfamily hydrolase, subfamily iia AK40_3596 ENOG4105CBT Fructose-1,6-bisphosphatase AK40_3599 ENOG4105MMD transcriptional regulator AK40_36 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AK40_3600 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AK40_3601 ENOG4107TXC Transcriptional regulator AK40_3602 ENOG41090T1 Membrane AK40_3607 ENOG4105FAA peptidase M23 AK40_3609 ENOG4105KZD Domain of unknown function (DUF1805) AK40_3610 ENOG4107R8B 5'-nucleotidase AK40_3613 ENOG4105DIW FeS assembly protein SUFB AK40_3614 ENOG4108UNV SUF system FeS assembly protein, NifU family AK40_3615 ENOG4105C9B Cysteine desulfurase AK40_3616 ENOG4105JRK feS assembly protein SufD AK40_3617 ENOG4105C3K feS assembly ATPase SufC AK40_3618 ENOG4105D01 (LipO)protein AK40_3619 ENOG4105D01 (LipO)protein AK40_3620 ENOG4108UMI ABC transporter, permease AK40_3626 ENOG41080E8 Transcriptional regulator, Spx MgsR family AK40_3636 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AK40_364 ENOG4105DUM transcriptional regulator, lysR family AK40_3644 ENOG4108W8B Beta-lactamase domain protein AK40_3647 ENOG4108IUW ABC transporter AK40_365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AK40_3652 ENOG4105C1G acyl-Coa dehydrogenase AK40_3653 ENOG4105CHU acetyl-coa acetyltransferase AK40_3656 ENOG4105DZ1 carboxypeptidase AK40_366 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AK40_3660 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AK40_3664 ENOG4108SUT Major Facilitator Superfamily AK40_3665 ENOG4107R7I amino acid AK40_3668 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AK40_367 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AK40_3670 ENOG4107AYK membrAne AK40_3678 ENOG4107ZTW SNARE associated Golgi AK40_368 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AK40_3680 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AK40_3681 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK40_3682 ENOG4105BZU Histidine kinase AK40_3686 ENOG4105C8Q Methyl-accepting chemotaxis AK40_3687 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AK40_3688 ENOG4105VG1 fes assembly suf system protein AK40_3689 ENOG4105D4Y metalloprotease AK40_3693 ENOG4107S91 Sodium hydrogen exchanger AK40_3694 ENOG4105NCW Trka-c domain protein AK40_3696 ENOG4108RMU ferritin dps family protein AK40_3699 ENOG4108URH decarboxylase AK40_37 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AK40_3703 ENOG4105D9N nucleoside AK40_3704 ENOG4105D9N nucleoside AK40_3707 ENOG4108RYK Nad-dependent epimerase dehydratase AK40_3710 ENOG4105CV8 reductase AK40_3711 ENOG4105F27 Major Facilitator AK40_3712 ENOG4105KVH Transcriptional regulator AK40_3715 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AK40_3716 ENOG4105D4A Cell wall formation (By similarity) AK40_3718 ENOG4105C8Q Methyl-accepting chemotaxis AK40_3720 ENOG4105WMR Protein CrcB homolog AK40_3725 ENOG4105C5H ABC transporter AK40_3726 ENOG4108MK9 spermidine N(1)-acetyltransferase AK40_3730 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AK40_3732 ENOG4108IPW abc transporter atp-binding protein AK40_3733 ENOG4105CM4 permease protein AK40_3738 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AK40_375 ENOG4105CVJ phosphoglycerate mutase AK40_3756 ENOG4105DUX Transporter AK40_3760 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AK40_3762 ENOG4105XZU Preprotein translocase, subunit SecG AK40_3763 ENOG41067MG lrgb family AK40_3773 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK40_3777 ENOG41090VF Stage v sporulation protein ac AK40_3778 ENOG4105CZ3 stage V sporulation protein ad AK40_3781 ENOG4105H67 Protein of unknown function (DUF421) AK40_3782 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AK40_3783 ENOG4105KRI phosphocarrier protein (HPr AK40_3785 ENOG4105CHW UPF0052 protein AK40_3787 ENOG4108Z4K mutator MutT protein AK40_3789 ENOG4105C3M thioredoxin reductase AK40_379 ENOG4105K56 Transcriptional regulator AK40_3791 ENOG4108S4C acetyltransferase AK40_3795 ENOG41086DT Membrane protein of unknown function AK40_3797 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AK40_3798 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AK40_38 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AK40_3801 ENOG4107TXC Transcriptional regulator AK40_3805 ENOG4105HMI Membrane AK40_3806 ENOG4105DUM transcriptional regulator, lysR family AK40_3808 ENOG4108WS4 fmn reductase AK40_3809 ENOG4105C5H ABC transporter AK40_381 ENOG4105CAQ asparagine synthetase AK40_3811 ENOG4105BZ1 (ABC) transporter AK40_3813 ENOG4105CN1 protease AK40_3814 ENOG4105CRP Part of the ABC transporter FtsEX involved in AK40_3815 ENOG4105CAK Cell division ATP-binding protein ftsE AK40_3817 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AK40_3819 ENOG4105MS2 ribosomal subunit Interface protein AK40_3820 ENOG4105VEQ Cold shock protein AK40_3821 ENOG41081UC Inherit from COG: Competence protein AK40_3824 ENOG4105KVH Transcriptional regulator AK40_3826 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AK40_3827 ENOG4108KGH TRANSCRIPTIONal AK40_3828 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AK40_3829 ENOG4105C6Y Udp-glucose 6-dehydrogenase AK40_3830 ENOG4105ESV Glycosyl transferase, family 4 AK40_3832 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AK40_3836 ENOG4105F8D glycoside hydrolase family 4 AK40_3837 ENOG4105VCP PTS System AK40_3838 ENOG4105CK1 PTS System AK40_3840 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AK40_3844 ENOG4105VCP PTS System AK40_3846 ENOG4105VZJ PTS System AK40_3849 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AK40_385 ENOG4105PGM cation diffusion facilitator family transporter AK40_3853 ENOG4105ECB domain protein AK40_3854 ENOG4107RSM transcriptional regulator AK40_3861 ENOG4105DAA L-lactate AK40_3862 ENOG4105D7V transposase AK40_3864 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AK40_3866 ENOG4105E0M Sulfatase AK40_387 ENOG4105DRR Transcriptional regulator, GntR family AK40_3871 ENOG4107R8N Glycosyl transferase, family 2 AK40_3873 ENOG4105C94 Transporter AK40_3874 ENOG41069ER domain protein AK40_3879 ENOG4105KBK Zinc finger, swim domain protein AK40_388 ENOG4108UZ3 Transporter AK40_3880 ENOG4105C0D helicase AK40_3886 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK40_3889 ENOG4107RBB ABC transporter, permease AK40_389 ENOG4105CKI cobalamin synthesis protein AK40_3890 ENOG4105C19 ABC transporter AK40_3894 ENOG4105CXY transporter AK40_3898 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK40_3899 ENOG4105CMR udp-glucose 4-epimerase AK40_39 ENOG4105CZV ABC transporter AK40_390 ENOG4108PJD permease AK40_3901 ENOG4108KGH TRANSCRIPTIONal AK40_3902 ENOG4105CMR udp-glucose 4-epimerase AK40_3903 ENOG4105C6Y Udp-glucose 6-dehydrogenase AK40_3909 ENOG4105D3Q Sugar transferase AK40_3910 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AK40_3911 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AK40_3912 ENOG4107YJ4 chain length determinant protein AK40_3913 ENOG4105HTX biosynthesis protein AK40_3914 ENOG4107YJ4 chain length determinant protein AK40_3917 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AK40_3918 ENOG4105FRN stage II sporulation protein AK40_3921 ENOG4105DY9 regulatoR AK40_3925 ENOG4106778 Protein of unknown function (DUF1146) AK40_3926 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AK40_3927 ENOG4105C8S subunit m AK40_3928 ENOG4105D65 subunit l AK40_393 ENOG4105DFD Na H antiporter AK40_3934 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AK40_3936 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AK40_3937 ENOG4105BZU Histidine kinase AK40_394 ENOG4105C9Q fumarate hydratase class II AK40_3947 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AK40_3948 ENOG41062M3 atp synthase AK40_3953 ENOG4108YZG isomerase AK40_3956 ENOG4108VGI doxx family AK40_3957 ENOG4107XC4 flavin reductase domain protein, FMN-binding AK40_3961 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AK40_3963 ENOG4108ZXQ stage ii sporulation protein r AK40_3964 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AK40_3965 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AK40_3968 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AK40_3969 ENOG4105CBT Fructose-1,6-bisphosphatase AK40_397 ENOG4107QJQ Mate efflux family protein AK40_3970 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AK40_3977 ENOG4105C1G acyl-Coa dehydrogenase AK40_3978 ENOG4105C1G acyl-Coa dehydrogenase AK40_3979 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AK40_398 ENOG4105EC3 peptidase S51, dipeptidase E AK40_3981 ENOG4105DF6 Fe-S oxidoreductase AK40_3982 ENOG41067QW Transcriptional regulator AK40_3989 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AK40_3990 ENOG4105KVY Required for disulfide bond formation in some proteins (By similarity) AK40_4 ENOG4105C4Y ABC transporter AK40_4001 ENOG4105BZU Histidine kinase AK40_4006 ENOG4105BZU Histidine kinase AK40_4007 ENOG4105KCT ABC transporter AK40_4008 ENOG4108M15 ABC transporter AK40_4009 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AK40_4011 ENOG4105IIU Aminopeptidase AK40_4015 ENOG4105EMN RNA polymerase sigma factor AK40_4017 ENOG410684U Domain of unknown function (DUF1934) AK40_402 ENOG4107QIV Cytochrome c biogenesis protein AK40_4021 ENOG4105CYW agmatinase AK40_4023 ENOG4105DXB Major Facilitator superfamily AK40_4024 ENOG4107SWG transcriptional regulator MERR family AK40_4025 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AK40_4026 ENOG4105BZ4 penicillin-binding protein AK40_4027 ENOG4108XFG YwhD family AK40_4028 ENOG4108Z4T Peptidase M50 AK40_4029 ENOG41069HH 4-oxalocrotonate tautomerase AK40_4030 ENOG4105DCI Phosphohydrolase AK40_4031 ENOG4108MES Periplasmic binding protein AK40_4032 ENOG4105E0A ABC, transporter AK40_4033 ENOG4105EHG Permease protein AK40_4034 ENOG4105DQ5 transport system permease protein AK40_4036 ENOG4108VCI transcription factor, rsfa family AK40_4039 ENOG4108IJ2 phosphate acetyltransferase AK40_4042 ENOG4108VKI Cell wall hydrolase AK40_4046 ENOG4107SVH Potassium channel protein AK40_4048 ENOG410667J hydrolase AK40_4049 ENOG4105VCH membrane AK40_4051 ENOG4108TU7 Inherit from COG: (ABC) transporter AK40_4052 ENOG4105CJ1 ABC, transporter AK40_4053 ENOG41090WU lipolytic protein G-D-S-L family AK40_4056 ENOG4105D6E homoserine dehydrogenase AK40_4061 ENOG4105D7V transposase AK40_4062 ENOG4108Y4K DNA-binding transcriptional activator AK40_4064 ENOG4105WH1 Two component transcriptional regulator luxr family AK40_4065 ENOG4105BZU Histidine kinase AK40_4066 ENOG4105DWF phosphomethylpyrimidine kinase AK40_4067 ENOG4105BZU Histidine kinase AK40_4068 ENOG4105VCD cytoplasmic protein AK40_4069 ENOG4105D22 carbon starvation protein AK40_4070 ENOG4105DY9 regulatoR AK40_4071 ENOG41079KZ Major Facilitator Superfamily AK40_4075 ENOG4105EN6 Membrane AK40_4076 ENOG4106YBV Methyl-accepting chemotaxis AK40_4078 ENOG4108S4H thioesterase Superfamily protein AK40_4080 ENOG4105JEU Glycosyl transferase, family 2 AK40_4081 ENOG4105C5H ABC transporter AK40_4085 ENOG4105CKK Glycosyl transferase, family 2 AK40_4086 ENOG41067SE Tetr family transcriptional regulator AK40_4088 ENOG4105E0X reductase AK40_4089 ENOG4106F5Q Membrane AK40_409 ENOG4106BRA Membrane AK40_4092 ENOG4105DY9 regulatoR AK40_4093 ENOG4108HRK Histidine kinase AK40_4094 ENOG4107RGD Major Facilitator superfamily AK40_4097 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AK40_4099 ENOG4105IW1 AmiS UreI transporter AK40_41 ENOG4105CJ1 ABC, transporter AK40_4101 ENOG4105CMR udp-glucose 4-epimerase AK40_4102 ENOG4108UT2 hemolysin iii AK40_4104 ENOG4105C1J atp-dependent rna helicase AK40_4107 ENOG4105DPN Oligoendopeptidase f AK40_4113 ENOG4105C0H protease AK40_4114 ENOG4105Q2H domain protein AK40_4117 ENOG4105BZU Histidine kinase AK40_4118 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK40_4124 ENOG4105CDU Replicative dna helicase AK40_4126 ENOG4105BZR domain protein AK40_4127 ENOG4108XMW Membrane AK40_4129 ENOG4108UUM single-stranded DNA-binding protein AK40_4131 ENOG4105C3G gtp-binding protein AK40_4132 ENOG4105VDK protein, conserved in bacteria AK40_4133 ENOG4105D8X mechanosensitive ion channel AK40_4134 ENOG4108ZDA Sporulation protein YyaC AK40_4135 ENOG4105FA0 parb-like partition protein AK40_4136 ENOG4107QJE Chromosome Partitioning Protein AK40_4140 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AK40_4142 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AK40_4146 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AK40_4147 ENOG410848D S4 domain protein YaaA AK40_4150 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AK40_4158 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AK40_416 ENOG4105CJ1 ABC, transporter AK40_4165 ENOG4105ZMH deoxynucleoside kinase AK40_4167 ENOG4105GTG Isochorismatase AK40_4168 ENOG4108Z6B deaminase AK40_4169 ENOG4105C6E dna polymerase iii AK40_4173 ENOG41067KS pro-sigma K processing AK40_4181 ENOG4105CXN decarboxylase AK40_4183 ENOG4105FA2 dna polymerase iii AK40_4184 ENOG4105MA4 psp1 domain protein AK40_4186 ENOG41060K3 Methyltransferase AK40_4188 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AK40_4189 ENOG4105KRN Transcriptional regulator, abrb family AK40_4191 ENOG4105F8V Hydrolase, tatD family AK40_4192 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AK40_4194 ENOG4105XFA sporulation peptidase YabG AK40_4195 ENOG4105W42 Veg protein AK40_4198 ENOG4105DFT pur operon repressor AK40_4199 ENOG4105KME endoribonuclease L-psp AK40_420 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AK40_4202 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AK40_4203 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AK40_4205 ENOG4108JA2 transcriptioN-repair coupling factor AK40_4206 ENOG4108M14 stage v sporulation protein t AK40_4208 ENOG4108IY2 MazG family AK40_4209 ENOG41082I2 s4 domain protein AK40_4210 ENOG4105VYY sporulation protein yabp AK40_4213 ENOG41060GV RNA binding s1 domain protein AK40_4218 ENOG4108UGV hypoxanthine phosphoribosyltransferase AK40_4219 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AK40_422 ENOG4108IJ0 Aspartate ammonia-lyase AK40_4222 ENOG4105C6T cysteine synthase AK40_4223 ENOG4105CRQ synthase (Component I) AK40_4224 ENOG4105DDQ anthranilate synthase AK40_4225 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AK40_4226 ENOG4105EEI dihydropteroate synthase AK40_4227 ENOG4105KRF dihydroneopterin aldolase AK40_4228 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AK40_423 ENOG4105C6K Malic enzyme AK40_4230 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AK40_4237 ENOG4108Z0C Uvrb UvrC protein AK40_4240 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AK40_4242 ENOG4105CTP PilT protein domain protein AK40_4246 ENOG4105D7W serine acetyltransferase AK40_4249 ENOG4105C2N RNA methyltransferase TrmH family group 3 AK40_4250 ENOG4105M0M Tetracycline resistance protein AK40_4251 ENOG4105QIV RNA polymerase AK40_4253 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AK40_4258 ENOG4107Y49 methyltransferase AK40_4261 ENOG4105XPM ribosomal protein AK40_4282 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AK40_4287 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AK40_4289 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AK40_429 ENOG41067QW Transcriptional regulator AK40_4291 ENOG41067V7 50S ribosomal protein L36 AK40_4297 ENOG4108JJB ABC transporter AK40_4298 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AK40_4299 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AK40_4304 ENOG4105D1F ATP-binding protein AK40_4307 ENOG4108NMV polysaccharide deacetylase AK40_4324 ENOG4105C8B TIGR00159 family AK40_4325 ENOG4107U5W ybbr family AK40_433 ENOG4105FVX AK40_4331 ENOG4105CMG Carbohydrate kinase AK40_4333 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AK40_4340 ENOG4108PSK reductase AK40_4341 ENOG4108UMI ABC transporter, permease AK40_4342 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AK40_4343 ENOG4105D01 (LipO)protein AK40_4344 ENOG4105EE1 crotonyl-CoA reductase AK40_4346 ENOG4105IQ5 FAD linked oxidase domain protein AK40_4349 ENOG4105C2C drug resistance transporter, Bcr CflA AK40_4351 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AK40_4352 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AK40_4353 ENOG4105C3U ABC transporter AK40_4354 ENOG4108JQ7 (ABC) transporter AK40_4359 ENOG4105U5Y Transcriptional regulator AK40_4361 ENOG4108J59 Extracellular solute-binding protein, family 5 AK40_4362 ENOG4108J59 Extracellular solute-binding protein, family 5 AK40_4364 ENOG4105II7 pyrroline-5-carboxylate reductase AK40_4365 ENOG4107XDY Nicotinamide Mononucleotide Transporter AK40_4367 ENOG4105E0C molybdate abc transporter AK40_4368 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AK40_4369 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AK40_4376 ENOG4105F6E Acyl-transferase AK40_4380 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AK40_4385 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AK40_4389 ENOG4105C5H ABC transporter AK40_4392 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AK40_4394 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AK40_4395 ENOG4105C3U ABC transporter AK40_4396 ENOG4108JQ7 (ABC) transporter AK40_4397 ENOG410667J hydrolase AK40_440 ENOG4105CSR polyphosphate kinase 2 AK40_4403 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AK40_4404 ENOG4105ERH Fumarylacetoacetate hydrolase AK40_4406 ENOG4105CUB amino acid AK40_4408 ENOG4105CPF Cell wall formation (By similarity) AK40_4409 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AK40_441 ENOG4105DXI Major Facilitator superfamily AK40_4411 ENOG4107ZXI Rhomboid family AK40_4414 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AK40_4415 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AK40_4417 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AK40_4437 ENOG4105K8N protein family UPF0079, ATPase AK40_4438 ENOG41072GX Peptidase M22 Glycoprotease AK40_4439 ENOG410801F ribosomal-protein-alanine acetyltransferase AK40_444 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AK40_4441 ENOG4105C5H ABC transporter AK40_4444 ENOG4108TYN CAAX amino terminal protease family protein AK40_4447 ENOG4107EV6 Inherit from COG: YD repeat protein AK40_4450 ENOG4105C7N Xanthine uracil vitamin C permease AK40_4452 ENOG4105BZU Histidine kinase AK40_4458 ENOG4107ZXU DSBA oxidoreductase AK40_446 ENOG4105EU0 Major facilitator Superfamily AK40_447 ENOG4105C6T cysteine synthase AK40_4472 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK40_4477 ENOG4105SX7 Transporter AK40_4483 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AK40_4484 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AK40_4485 ENOG4105C83 adenylosuccinate lyase AK40_4487 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AK40_4492 ENOG4108V3E phosphoribosylglycinamide formyltransferase AK40_4494 ENOG4105C12 Phosphoribosylglycinamide synthetase AK40_4499 ENOG4105C4R Atp-dependent dna helicase AK40_4505 ENOG4108W2Y isochorismatase AK40_4507 ENOG4108UMI ABC transporter, permease AK40_4508 ENOG4105D01 (LipO)protein AK40_451 ENOG4105C8J )-transporter AK40_4512 ENOG410834F Transcriptional regulator AK40_4513 ENOG4107I77 yiaA/B two helix domain AK40_4517 ENOG4105CBD Diacylglycerol kinase AK40_4518 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AK40_4519 ENOG4108JPW Aminotransferase AK40_4521 ENOG4105C26 Dehydrogenase AK40_4522 ENOG4105KPY Small multidrug resistance protein AK40_4526 ENOG4105D9N nucleoside AK40_4527 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AK40_4529 ENOG4105BZU Histidine kinase AK40_453 ENOG4105X5K response regulator receiver protein AK40_4530 ENOG4108W15 Protein of unknown function (DUF1456) AK40_4533 ENOG4105DTQ mandelate racemase muconate lactonizing AK40_4534 ENOG4105DFD Na H antiporter AK40_454 ENOG4105H67 Protein of unknown function (DUF421) AK40_4540 ENOG4105D3R alkyl hydroperoxide reductase AK40_4541 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AK40_4543 ENOG4107W7X Aldolase AK40_4544 ENOG4105EHG Permease protein AK40_4545 ENOG4105DQ5 transport system permease protein AK40_4546 ENOG4108V5C ABC transporter AK40_4550 ENOG4106UIA AK40_4551 ENOG4106UIA AK40_4555 ENOG4105BZU Histidine kinase AK40_4559 ENOG410756H nucleotidyltransferase AK40_4560 ENOG4105D2S major facilitator superfamily AK40_4563 ENOG4105E5Q amino acid AbC transporter AK40_4564 ENOG4105EAB amino acid AbC transporter AK40_4566 ENOG4105C8Q Methyl-accepting chemotaxis AK40_4567 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AK40_4569 ENOG4105CI1 PTS System AK40_457 ENOG4106KE4 Dehydrogenase AK40_4575 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AK40_4578 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AK40_4581 ENOG4105C5H ABC transporter AK40_4588 ENOG41062JF Transcriptional regulator AK40_4592 ENOG4105DEU major facilitator superfamily AK40_4599 ENOG4108N0M stress protein AK40_4600 ENOG4106FN3 tellurium resistance protein AK40_4601 ENOG4106FN3 tellurium resistance protein AK40_4602 ENOG4107TS3 membrane protein, TerC AK40_4603 ENOG4108TTB tellurium resistance protein AK40_4607 ENOG4105KJF protein tyrosine phosphatase AK40_4609 ENOG4107U9T Pfam:Ribonuclease_BN AK40_461 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AK40_4610 ENOG4105C59 p-type ATPase AK40_4611 ENOG4108IPJ Membrane AK40_4615 ENOG4107ZTW SNARE associated Golgi AK40_4618 ENOG410606W general stress protein AK40_4619 ENOG4105UPD Calcium Proton AK40_462 ENOG4105CHR reductase AK40_4627 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AK40_4629 ENOG4108JUB Transcriptional regulator AK40_463 ENOG4105CM2 brancheD-chain amino acid aminotransferase AK40_4631 ENOG4108IQI permease AK40_4637 ENOG4105CSV Glutaminase AK40_4639 ENOG4108A04 Beta-lactamase AK40_464 ENOG4105C7K acetolactate synthase AK40_4642 ENOG4105CKK Glycosyl transferase, family 2 AK40_4643 ENOG4107QQG Dehydrogenase AK40_4644 ENOG4105C3I Nad-dependent epimerase dehydratase AK40_4647 ENOG4105F1A Pyruvate formate-lyase AK40_4651 ENOG4105CI2 imidazolone-5-propionate hydrolase AK40_4652 ENOG4105ECP epimerase AK40_4658 ENOG41067AE Membrane-bound metal-dependent hydrolase AK40_4659 ENOG4105CEN a g-specific adenine glycosylase AK40_466 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AK40_4660 ENOG4106BXE AK40_4665 ENOG4105BZ1 (ABC) transporter AK40_4666 ENOG4107NBY Membrane AK40_4667 ENOG4105CBC glutamate synthase AK40_4669 ENOG4108IUW ABC transporter AK40_4673 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AK40_4674 ENOG4105G5W regulator Fur family AK40_468 ENOG4105C7B Threonine dehydratase AK40_4702 ENOG4105BZ1 (ABC) transporter AK40_4705 ENOG4108JQC penicillin-binding protein 1A AK40_4706 ENOG4107ZQN disulfide bond AK40_4709 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AK40_4711 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AK40_4712 ENOG4105BZU Histidine kinase AK40_4714 ENOG4105CYN Serine protein kinase AK40_4720 ENOG4105C94 Transporter AK40_4723 ENOG4105DZ6 Band 7 protein AK40_4725 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AK40_4726 ENOG4108V9W transcriptional regulatory protein AK40_4727 ENOG4105D4T Citrate transporter AK40_473 ENOG4105C6X Major Facilitator AK40_4731 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AK40_4732 ENOG4108STX response regulator AK40_4733 ENOG4105US7 Histidine kinase AK40_4738 ENOG4108MRH transcriptional regulatory protein AK40_474 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AK40_4740 ENOG4105C6K Malic enzyme AK40_4742 ENOG4108UZ3 Transporter AK40_4743 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AK40_4745 ENOG4105BZU Histidine kinase AK40_4746 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK40_4748 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AK40_4749 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AK40_4750 ENOG4108JB9 formate dehydrogenase AK40_4754 ENOG4105CUB amino acid AK40_4756 ENOG4105C59 p-type ATPase AK40_4757 ENOG4105DAP Nicotinate phosphoribosyltransferase AK40_4765 ENOG41073R8 VanW family AK40_4766 ENOG4108KGH TRANSCRIPTIONal AK40_4767 ENOG4105D9N nucleoside AK40_4768 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AK40_4769 ENOG4105C37 (CBS) domain AK40_4770 ENOG4108IJ0 Aspartate ammonia-lyase AK40_4771 ENOG4105DAA L-lactate AK40_4774 ENOG4105DUX Transporter AK40_4775 ENOG4108MES Periplasmic binding protein AK40_4776 ENOG4105DQ5 transport system permease protein AK40_4777 ENOG4108IHU transport system permease protein AK40_4778 ENOG4105E0A ABC, transporter AK40_478 ENOG4105DY9 regulatoR AK40_4780 ENOG4105EXW epimerase dehydratase AK40_4782 ENOG4107T89 von Willebrand factor, type A AK40_4783 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AK40_4784 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AK40_4786 ENOG4105BZU Histidine kinase AK40_4787 ENOG4105D5Q Arginine ornithine antiporter AK40_4788 ENOG4107414 GntR family transcriptional regulator AK40_4789 ENOG4105C5Y PTS System AK40_479 ENOG4105CYC Transferase AK40_4790 ENOG4105CG3 alpha amylase, catalytic region AK40_4793 ENOG4105E1K spore germination protein AK40_4794 ENOG4108XG2 Histidine kinase AK40_4795 ENOG4105WH1 Two component transcriptional regulator luxr family AK40_4796 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AK40_4799 ENOG4105CRN Aminoglycoside phosphotransferase AK40_4800 ENOG4105BZG amino acid carrier protein AK40_4801 ENOG4105CDA abc transporter atp-binding protein AK40_4802 ENOG4105CT1 (ABC) transporter AK40_4803 ENOG4105EAD ABC transporter AK40_4804 ENOG4105DRP amino acid AbC transporter AK40_4805 ENOG4108IQI permease AK40_4808 ENOG4105GFR rna polymerase sigma factor AK40_4810 ENOG4105D29 Helix-turn-helix type 11 domain protein AK40_4811 ENOG4105NAE bifunctional deaminase-reductase domain protein AK40_4812 ENOG4105BZU Histidine kinase AK40_4815 ENOG4105CHH sulfate transporter AK40_4816 ENOG41068KF Universal stress protein AK40_4818 ENOG4105DEF Extracellular solute-binding protein, family 5 AK40_4820 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AK40_4821 ENOG4108JQ7 (ABC) transporter AK40_4823 ENOG4105CXY transporter AK40_4824 ENOG41067TZ transcriptional regulator, MarR family AK40_4825 ENOG4105C0R drug resistance transporter emrb qaca subfamily AK40_4826 ENOG4105ETE Transcriptional regulator (LacI family AK40_4827 ENOG4108RVA ribokinase AK40_4829 ENOG4105C2J ABC transporter AK40_483 ENOG4108IBT Inherit from COG: transposase AK40_4830 ENOG4105CNN ABC, transporter AK40_4831 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AK40_4832 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AK40_4844 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AK40_4845 ENOG41069ER domain protein AK40_4846 ENOG4105VZ8 Transcriptional regulator AK40_4847 ENOG4107D63 AK40_4849 ENOG4105DUX Transporter AK40_4854 ENOG4105C85 amino acid AK40_4855 ENOG4105C7N Xanthine uracil vitamin C permease AK40_4858 ENOG4105MA6 gCN5-related N-acetyltransferase AK40_4863 ENOG4105BZ9 Cytochrome C oxidase, subunit I AK40_4864 ENOG4105E2S oxidase) subunit II AK40_4867 ENOG4106CAD Protein of unknown function (DUF3311) AK40_4868 ENOG4105E1V na solute symporter AK40_4871 ENOG4108NHD germination protein AK40_4872 ENOG4105CE1 Ferrous iron transport protein b AK40_4873 ENOG4105CE1 Ferrous iron transport protein b AK40_4874 ENOG4105CE1 Ferrous iron transport protein b AK40_4875 ENOG4105CVA phosphate AK40_4876 ENOG4105C8U phosphate abc transporter AK40_4877 ENOG4105E2Z phosphate ABC transporter (Permease AK40_49 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AK40_4904 ENOG41080XQ Signal transduction protein with cbs domains AK40_4908 ENOG4105ETU transcriptional activator (TenA AK40_491 ENOG41068WN AK40_4910 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AK40_4912 ENOG4108VEU Thiamine monophosphate synthase AK40_4913 ENOG41080HI glycine oxidase AK40_4916 ENOG4105D06 uba thif-type nad fad binding protein AK40_4917 ENOG4105DWF phosphomethylpyrimidine kinase AK40_492 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK40_4926 ENOG4108INS Transcriptional regulator AK40_4931 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AK40_4933 ENOG4105C7N Xanthine uracil vitamin C permease AK40_4935 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AK40_4939 ENOG4105C5Y PTS System AK40_4946 ENOG4108B31 Spore germination protein AK40_4950 ENOG4107Y03 Nitroreductase AK40_4951 ENOG4105ED1 spovr family AK40_4952 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AK40_4953 ENOG4105XTG Pfam:DUF156 AK40_4954 ENOG4105VFE sira family AK40_4955 ENOG4107TPS domain protein AK40_4956 ENOG4105VFE sira family AK40_4957 ENOG41085GJ domain protein AK40_4959 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AK40_4960 ENOG41087NI Sulfite exporter TauE/SafE AK40_4962 ENOG4108KGH TRANSCRIPTIONal AK40_4967 ENOG4105EMD TRANSCRIPTIONal AK40_4968 ENOG4105VCP PTS System AK40_4969 ENOG4105VZJ PTS System AK40_497 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AK40_4973 ENOG41069ER domain protein AK40_4974 ENOG4107RBB ABC transporter, permease AK40_4975 ENOG4105C19 ABC transporter AK40_4982 ENOG4105WEF catalase AK40_4989 ENOG4107T5V SNARE associated Golgi AK40_4996 ENOG4105CUB amino acid AK40_4997 ENOG4107RWR Sodium hydrogen exchanger AK40_4999 ENOG4106KNT transcriptional regulator AK40_5 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AK40_50 ENOG4105EA8 2-Nitropropane dioxygenase AK40_500 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AK40_5008 ENOG4108YXU transcriptional regulator AsnC family AK40_5010 ENOG4105KPY Small multidrug resistance protein AK40_5011 ENOG4105KPY Small multidrug resistance protein AK40_5015 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AK40_5016 ENOG4105E5W Transporter AK40_5018 ENOG4107RKG DJ-1/PfpI family AK40_5019 ENOG4105CH6 catalase AK40_502 ENOG4105C0X amino acid AK40_5021 ENOG4105D5Q Arginine ornithine antiporter AK40_5022 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AK40_5024 ENOG4105C26 Dehydrogenase AK40_5025 ENOG4105BZ1 (ABC) transporter AK40_5026 ENOG4105BZ1 (ABC) transporter AK40_5028 ENOG4105DRP amino acid AbC transporter AK40_5029 ENOG4105CDA abc transporter atp-binding protein AK40_5032 ENOG410839P AK40_5039 ENOG4107FQX Alpha-acetolactate decarboxylase AK40_5043 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AK40_5044 ENOG4105D4P Coproporphyrinogen iii oxidase AK40_5047 ENOG4105CHH sulfate transporter AK40_5055 ENOG4106AKK s-layer domain-containing protein AK40_5056 ENOG4106AKK s-layer domain-containing protein AK40_5058 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AK40_5060 ENOG4105CGU Enoyl-CoA hydratase AK40_5065 ENOG4105DER m42 family AK40_5068 ENOG4108ZJ4 polysaccharide deacetylase AK40_5069 ENOG41086D8 Transcriptional regulator AK40_5070 ENOG4105G7B Protein of unknown function (DUF2992) AK40_5076 ENOG4105CTU Proline racemase AK40_5084 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AK40_5086 ENOG4108JQ7 (ABC) transporter AK40_5088 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AK40_5092 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AK40_5096 ENOG4105CSH Transporter AK40_5098 ENOG4108MRH transcriptional regulatory protein AK40_51 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AK40_511 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK40_5110 ENOG4105C0D helicase AK40_5122 ENOG4105CDU Replicative dna helicase AK40_5128 ENOG4105C0R drug resistance transporter emrb qaca subfamily AK40_513 ENOG4107RHR regulatoR AK40_5141 ENOG4107P5I polyketide synthase AK40_5142 ENOG4108IG5 Transcriptional regulator AK40_5145 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AK40_515 ENOG4105D9N nucleoside AK40_5151 ENOG4105CMT Dihydroxyacetone kinase AK40_5153 ENOG4105CMT Dihydroxyacetone kinase AK40_5154 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AK40_5155 ENOG410847I Transcriptional regulator, BadM Rrf2 family AK40_5158 ENOG410780I phosphoprotein phosphatase activity AK40_516 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AK40_5160 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AK40_5173 ENOG4105WN5 stage II sporulation protein AK40_5175 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AK40_5177 ENOG4108MJI response regulator AK40_5178 ENOG4105BZU Histidine kinase AK40_5179 ENOG4105BZU Histidine kinase AK40_5184 ENOG4105K8R UPF0145 protein AK40_5192 ENOG4107VRP DNA repair exonuclease AK40_5193 ENOG4106D4I domain protein AK40_5203 ENOG4108MUZ hydrolase AK40_5207 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AK40_5210 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AK40_5215 ENOG4105EMN RNA polymerase sigma factor AK40_522 ENOG4107RAQ aminopeptidase AK40_5220 ENOG4105C57 major facilitator superfamily AK40_5221 ENOG4105C0R drug resistance transporter emrb qaca subfamily AK40_5223 ENOG4105EEM helicase AK40_5224 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AK40_5229 ENOG4105K59 histidine triad (HIT) protein AK40_523 ENOG4107R16 Multicopper oxidase AK40_5236 ENOG410905X membrane-flanked domain protein AK40_5237 ENOG4105CKV Membrane AK40_5241 ENOG41060BG Tetr family transcriptional regulator AK40_5245 ENOG410905X membrane-flanked domain protein AK40_5246 ENOG4105CKV Membrane AK40_5247 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AK40_5248 ENOG4105BZ4 penicillin-binding protein AK40_5251 ENOG4105C1Q protoporphyrinogen oxidase AK40_5257 ENOG4105NA0 Transcriptional regulator AK40_5260 ENOG4105ECB domain protein AK40_5265 ENOG4106AXD AK40_5266 ENOG4108RQ5 Beta-lactamase domain-containing protein AK40_5267 ENOG4105DF9 Lipoate-protein, ligase AK40_5269 ENOG4105CEY Amp-dependent synthetase and ligase AK40_5280 ENOG4105ST3 Transcriptional regulator AK40_5281 ENOG4105ENX hydrolase AK40_5282 ENOG4107RN3 metallophosphoesterase AK40_5284 ENOG4107TVP HD domain protein AK40_5286 ENOG4108AEY RNA polymerase sigma factor AK40_5287 ENOG41086D8 Transcriptional regulator AK40_5289 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK40_5293 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AK40_5297 ENOG4105ZU5 s-layer protein AK40_5298 ENOG4107QP3 malate synthase g AK40_53 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AK40_5301 ENOG4105VEQ Cold shock protein AK40_5304 ENOG4105XVF Competence transcription factor AK40_5318 ENOG4105ERH Fumarylacetoacetate hydrolase AK40_532 ENOG4108T5E Copper resistance protein AK40_5323 ENOG4105CAQ asparagine synthetase AK40_5324 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AK40_5325 ENOG4105CH6 catalase AK40_5326 ENOG4105BZU Histidine kinase AK40_533 ENOG4105KTB nuclear export factor GLE1 AK40_5330 ENOG4105QNR S1 RNA binding domain protein AK40_5332 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AK40_5334 ENOG4107AYK membrAne AK40_5335 ENOG41073B9 AK40_5337 ENOG4108KP7 hydrolase AK40_5339 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AK40_5344 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AK40_5345 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AK40_5348 ENOG4105C31 Tryptophanyl-tRNA synthetase AK40_535 ENOG4107RT3 EamA-like transporter family AK40_5351 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AK40_5352 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AK40_5354 ENOG4108JQ7 (ABC) transporter AK40_5355 ENOG4105UQX Mate efflux family protein AK40_5359 ENOG4108ZCF integral membrane protein AK40_536 ENOG4105GZI Transcriptional regulator AK40_5361 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AK40_5363 ENOG4105DPN Oligoendopeptidase f AK40_5366 ENOG4108Z18 K06886 hemoglobin AK40_5367 ENOG4105MIX Adenylate cyclase AK40_537 ENOG4108Z40 Transcriptional regulator AK40_5370 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AK40_5371 ENOG4105EMS pseudouridine synthase AK40_5375 ENOG4105K64 Glycosyl transferase, family 2 AK40_5379 ENOG4107TVC Glycosyl transferase, family 2 AK40_538 ENOG4107ZXU DSBA oxidoreductase AK40_5383 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AK40_5384 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AK40_5386 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AK40_539 ENOG4108TVJ Nitroreductase AK40_5394 ENOG4105EKQ RNA-directed DNA polymerase AK40_5402 ENOG4105CK7 Sodium proline symporter AK40_5403 ENOG4105CRQ synthase (Component I) AK40_5404 ENOG4105DDQ anthranilate synthase AK40_541 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AK40_542 ENOG4106F5Q Membrane AK40_5421 ENOG4105C7S Dehydrogenase AK40_5423 ENOG4105VZ8 Transcriptional regulator AK40_543 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AK40_5447 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AK40_545 ENOG4105CKI cobalamin synthesis protein AK40_5450 ENOG4108IUX (ABC) transporter AK40_5451 ENOG4105RHA ABC transporter, permease AK40_5454 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AK40_5456 ENOG4105DZ1 carboxypeptidase AK40_5457 ENOG4105VFR signal peptidase AK40_5463 ENOG4105C26 Dehydrogenase AK40_5465 ENOG4105F38 ABC transporter, permease AK40_5466 ENOG4105D38 putrescine abc transporter AK40_5467 ENOG4107RUE extracellular solute-binding protein family 1 AK40_5469 ENOG4105EYF MMPL domain protein AK40_5471 ENOG4108YBP pseudouridine synthase AK40_5473 ENOG4105K4I Scp-like extracellular AK40_5474 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AK40_5475 ENOG4105CQB FAD linked oxidase domain protein AK40_5478 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK40_5479 ENOG4105BZU Histidine kinase AK40_5480 ENOG4105JXH GntR family transcriptional regulator AK40_5484 ENOG4106A3R peptidase AK40_5486 ENOG4108QTI )-transporter AK40_5487 ENOG4107TS3 membrane protein, TerC AK40_5488 ENOG4105CZN Potassium uptake protein AK40_5489 ENOG410681C small acid-soluble spore protein AK40_549 ENOG4108Z7G MaoC domain protein dehydratase AK40_5490 ENOG4108Z7G MaoC domain protein dehydratase AK40_5494 ENOG4105CHR reductase AK40_5496 ENOG4105MWK D-amino acid dehydrogenase, small subunit AK40_5498 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AK40_550 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AK40_5501 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AK40_5511 ENOG41060AI SEC-C motif AK40_552 ENOG4105C0Z ABC transporter AK40_553 ENOG4108IV0 ABC, transporter AK40_5530 ENOG4106F1P AAA ATPase, central domain protein AK40_5539 ENOG4105EKQ RNA-directed DNA polymerase AK40_554 ENOG4105C32 Amino acid ABC transporter (Permease) AK40_5550 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AK40_556 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family AK40_5563 ENOG4107QHF type ii secretion system protein e AK40_5576 ENOG4105CDU Replicative dna helicase AK40_5600 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) AK40_562 ENOG4105C4M (Ubiquinol oxidase) subunit I AK40_5628 ENOG4105CNU cell division protein FtsK AK40_563 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AK40_564 ENOG4108JJ9 ABC, transporter AK40_565 ENOG4108JJ8 (ABC) transporter AK40_5651 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AK40_5661 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AK40_5667 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AK40_5668 ENOG4108FPN Integrase AK40_5673 ENOG4105BZU Histidine kinase AK40_5674 ENOG4108VB1 regulatoR AK40_568 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AK40_5681 ENOG4105C6E dna polymerase iii AK40_5690 ENOG4108KU9 integrase family AK40_5691 ENOG4108FPN Integrase AK40_5705 ENOG4108ZJ4 polysaccharide deacetylase AK40_5706 ENOG41086D8 Transcriptional regulator AK40_5708 ENOG4105G7B Protein of unknown function (DUF2992) AK40_5713 ENOG4108FPN Integrase AK40_573 ENOG4105BZ1 (ABC) transporter AK40_574 ENOG4105EFI regulatoR AK40_575 ENOG4105EB3 Histidine kinase AK40_5753 ENOG4105KRN Transcriptional regulator, abrb family AK40_5755 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AK40_5770 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AK40_5771 ENOG4105E09 nadh pyrophosphatase AK40_578 ENOG4108VQJ O-methyltransferase AK40_5784 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AK40_579 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AK40_5792 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AK40_5793 ENOG4105ENA helicase AK40_5794 ENOG4105EKQ RNA-directed DNA polymerase AK40_5795 ENOG4105ENA helicase AK40_5796 ENOG4105FA2 dna polymerase iii AK40_58 ENOG4105NQC Flavodoxin AK40_580 ENOG4108ZJ4 polysaccharide deacetylase AK40_5800 ENOG4105DUX Transporter AK40_5812 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AK40_5826 ENOG4106E8G AK40_5834 ENOG4108ZJ4 polysaccharide deacetylase AK40_5839 ENOG4106E8G AK40_584 ENOG4105D6E homoserine dehydrogenase AK40_5853 ENOG4105D7V transposase AK40_5857 ENOG4105D7V transposase AK40_5859 ENOG4105BZU Histidine kinase AK40_5860 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK40_5874 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AK40_589 ENOG4108KGH TRANSCRIPTIONal AK40_591 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AK40_592 ENOG4105BZU Histidine kinase AK40_5922 ENOG4105VIZ double-strand break repair protein AK40_593 ENOG4107VMI polysaccharide deacetylase AK40_5934 ENOG4105CNU cell division protein FtsK AK40_595 ENOG4105KT7 mgtC SapB transporter AK40_596 ENOG4105VRR gCN5-related N-acetyltransferase AK40_5964 ENOG4105CID antiterminator AK40_5965 ENOG4105C5Y PTS System AK40_5966 ENOG4105CS2 ec 3.2.1.21 AK40_598 ENOG4105DUU IucA IucC family protein AK40_599 ENOG4105CEY Amp-dependent synthetase and ligase AK40_5992 ENOG4105DHF Membrane AK40_5999 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AK40_6 ENOG4107RCV ABC transporter, permease AK40_6011 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AK40_6016 ENOG4108IBT Inherit from COG: transposase AK40_6019 ENOG41089BK Glutamine amido-transferase AK40_602 ENOG4108WBH protein TIM barrel AK40_6020 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AK40_6027 ENOG4108IMY Transcriptional regulator AK40_6029 ENOG4107VMI polysaccharide deacetylase AK40_603 ENOG4105YWU small acid-soluble spore protein AK40_6030 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AK40_6031 ENOG4105NA0 Transcriptional regulator AK40_6034 ENOG4108IMY Transcriptional regulator AK40_6035 ENOG4105BZC d-serine deaminase AK40_6037 ENOG4105CZV ABC transporter AK40_6040 ENOG4105D9P serine threonine protein kinase AK40_605 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AK40_6054 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AK40_606 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AK40_6065 ENOG4108J59 Extracellular solute-binding protein, family 5 AK40_6076 ENOG4107QJE Chromosome Partitioning Protein AK40_6118 ENOG4105K4H Nlp p60 protein AK40_6136 ENOG4105C9U ATP-dependent DNA helicase RecQ AK40_6150 ENOG4106CGH Phage Mu protein F like protein AK40_6151 ENOG4108MDF Phage Portal Protein AK40_6157 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AK40_616 ENOG4105KRN Transcriptional regulator, abrb family AK40_6164 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) AK40_6175 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AK40_618 ENOG4105YVS arsR family transcriptional regulator AK40_6181 ENOG4106CVF DNA replication protein AK40_619 ENOG4107SET aldo keto reductase AK40_6190 ENOG4105WXW Antirepressor AK40_620 ENOG4107XZQ multidrug resistance protein AK40_6205 ENOG4107QJE Chromosome Partitioning Protein AK40_6213 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AK40_6219 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AK40_6220 ENOG4108FPN Integrase AK40_6225 ENOG4105XSJ toxin secretion phage lysis holin AK40_6235 ENOG41060SN AK40_6243 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) AK40_625 ENOG4105C8Q Methyl-accepting chemotaxis AK40_6255 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AK40_6262 ENOG4105CDU Replicative dna helicase AK40_6271 ENOG4105XB7 anti-repressor protein AK40_628 ENOG4108K88 Membrane AK40_6287 ENOG4105XSJ toxin secretion phage lysis holin AK40_629 ENOG4108WPJ Ferritin-like domain AK40_6307 ENOG4105D0M Protease HtpX homolog AK40_6312 ENOG4107JM4 Tetratricopeptide repeat AK40_632 ENOG4105DEN Luciferase family AK40_636 ENOG4107QM2 Aldo Keto reductase AK40_637 ENOG4105CKI cobalamin synthesis protein AK40_641 ENOG4108IBT Inherit from COG: transposase AK40_642 ENOG4105DSE periplasmic solute binding protein AK40_644 ENOG4105K4T epimerase AK40_646 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AK40_65 ENOG4107QMU Mate efflux family protein AK40_651 ENOG4105CVJ phosphoglycerate mutase AK40_655 ENOG4107T5V SNARE associated Golgi AK40_658 ENOG4108PJD permease AK40_66 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AK40_660 ENOG4108S4H thioesterase Superfamily protein AK40_661 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AK40_665 ENOG4105SXS Protein of unknown function (DUF456) AK40_666 ENOG4105C37 (CBS) domain AK40_670 ENOG4108Z7R Chaperone CsaA AK40_673 ENOG4108ZRV stage ii sporulation protein p AK40_675 ENOG4108VXD carboxy-peptidase AK40_677 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AK40_681 ENOG4105EFA 4-hydroxyphenylacetate AK40_683 ENOG4105U1N riboflavin AK40_686 ENOG4105KME endoribonuclease L-psp AK40_692 ENOG41069HH 4-oxalocrotonate tautomerase AK40_694 ENOG4108X4Q Hydrolase AK40_696 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AK40_697 ENOG4107RBS Methyltransferase AK40_700 ENOG41087PP glycosyltransferase MGT family AK40_701 ENOG4108JYZ YitT family AK40_702 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AK40_708 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AK40_72 ENOG4105CZN Potassium uptake protein AK40_724 ENOG4105KBJ sporulation protein ytfj AK40_729 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AK40_73 ENOG41063Y9 AK40_733 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AK40_734 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AK40_736 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AK40_737 ENOG4105EMN RNA polymerase sigma factor AK40_74 ENOG4105KBJ sporulation protein ytfj AK40_740 ENOG4105CNW domain protein AK40_742 ENOG4108V06 Glutathione peroxidase AK40_745 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AK40_749 ENOG4108IUE nitrate reductase beta subunit AK40_750 ENOG4105R3A Nitrate reductase AK40_752 ENOG4107V6Q Cyclic nucleotide-binding domain AK40_753 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AK40_754 ENOG4105D06 uba thif-type nad fad binding protein AK40_755 ENOG4105CVM Molybdenum cofactor synthesis domain protein AK40_756 ENOG4108ZAF Molybdopterin AK40_760 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AK40_761 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AK40_762 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AK40_763 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AK40_764 ENOG4108IFG nitrite reductase, (NAD(P)H) AK40_765 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AK40_772 ENOG4105MCT stage V sporulation protein S AK40_780 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AK40_786 ENOG4105C5H ABC transporter AK40_789 ENOG4108UUM single-stranded DNA-binding protein AK40_79 ENOG4105CM2 brancheD-chain amino acid aminotransferase AK40_795 ENOG4107YX5 Pfam:DUF548 AK40_796 ENOG4105C75 arginyL-tRNA synthetase AK40_80 ENOG4105C7K acetolactate synthase AK40_803 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AK40_804 ENOG4105C5S asparaginyl-tRNA synthetase AK40_808 ENOG4105EC2 ftsk spoIIIe AK40_81 ENOG4108ZP8 Acetolactate synthase small subunit AK40_831 ENOG4105BZW Glycerate kinase AK40_832 ENOG4107QPK )-transporter AK40_833 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AK40_834 ENOG41062D9 Histidine kinase AK40_837 ENOG4105C8J )-transporter AK40_841 ENOG4107XGZ Hydrolase AK40_842 ENOG4105CY2 Citrate transporter AK40_843 ENOG4105C0A alcohol dehydrogenase AK40_846 ENOG4105KD7 acetyltransferase AK40_847 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AK40_852 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AK40_856 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AK40_860 ENOG4107RVG penicillin-binding protein AK40_862 ENOG4105E9Q Acyl-transferase AK40_863 ENOG4108UT2 hemolysin iii AK40_865 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AK40_867 ENOG4108RCR degv family AK40_868 ENOG4105E8R UPF0173 metal-dependent hydrolase AK40_869 ENOG4108KF3 Electron transport protein SCO1 SenC AK40_870 ENOG4107Y70 Heat shock protein AK40_871 ENOG4105CAQ asparagine synthetase AK40_875 ENOG4108MES Periplasmic binding protein AK40_876 ENOG4105F0I Aminotransferase AK40_883 ENOG4105D8X mechanosensitive ion channel AK40_884 ENOG4105BZU Histidine kinase AK40_885 ENOG4105WH1 Two component transcriptional regulator luxr family AK40_886 ENOG4106KNT transcriptional regulator AK40_892 ENOG4105CMG Carbohydrate kinase AK40_898 ENOG4108IJ8 ABC transporter AK40_899 ENOG4105E90 ABC transporter AK40_906 ENOG4105C37 (CBS) domain AK40_911 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AK40_914 ENOG4107S4Y M20 DapE family protein YgeY AK40_915 ENOG4108TSC N-acetyltransferase AK40_916 ENOG4108JUB Transcriptional regulator AK40_917 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AK40_925 ENOG4108N23 SpoOM-related protein AK40_927 ENOG410841Q phosphoesterase PA-phosphatase related protein AK40_928 ENOG4105SZ6 Thioredoxin AK40_940 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AK40_951 ENOG4105BZ4 penicillin-binding protein AK40_953 ENOG4105CZM Major Facilitator AK40_954 ENOG4105W8X HesB YadR YfhF-family protein AK40_956 ENOG4105DXD 2-methylcitrate dehydratase AK40_957 ENOG4105CR4 methylisocitrate lyase AK40_958 ENOG4105C1G acyl-Coa dehydrogenase AK40_959 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AK40_96 ENOG4107RVV histidinol phosphate phosphatase, hisj family AK40_961 ENOG4105N14 lysine exporter protein LysE YggA AK40_962 ENOG4105E39 Enoyl-CoA hydratase AK40_965 ENOG4107RFY SbcCD D subunit AK40_972 ENOG4105FCD Major Facilitator AK40_973 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AK40_974 ENOG4105E4F Isochorismate synthase AK40_975 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AK40_976 ENOG4105WQI isochorismatase AK40_977 ENOG4105CEY Amp-dependent synthetase and ligase AK40_978 ENOG4105WQT MbtH domain protein AK40_979 ENOG4105C0R drug resistance transporter emrb qaca subfamily AK40_982 ENOG4105K70 DNA-binding protein AK40_986 ENOG4105BZG amino acid carrier protein AK40_99 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AK40_990 ENOG4105FE9 pseudouridine synthase AK40_991 ENOG4105C22 threonyL-tRNA synthetase AK40_993 ENOG4105C19 ABC transporter AK40_996 ENOG4107SKW Inherit from COG: Alpha beta hydrolase