locus-tag	class	description
AK40_1	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AK40_10	COG1349	DNA-binding transcription factor activity
AK40_100	COG1368	sulfuric ester hydrolase activity
AK40_1001	COG2226	methyltransferase
AK40_1010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_1017	COG1247	-acetyltransferase
AK40_102	COG0019	diaminopimelate decarboxylase activity
AK40_1025	COG2226	methyltransferase
AK40_1026	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_1028	COG1278	Cold shock
AK40_1031	COG0010	Belongs to the arginase family
AK40_1033	COG0583	DNA-binding transcription factor activity
AK40_1034	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AK40_1037	COG0583	DNA-binding transcription factor activity
AK40_1038	COG2258	MOSC domain
AK40_1041	COG1132	(ABC) transporter
AK40_1042	COG1132	(ABC) transporter
AK40_1045	COG1280	lysine exporter protein (LysE YggA)
AK40_1046	COG1396	sequence-specific DNA binding
AK40_1053	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AK40_1056	COG1595	DNA-templated transcription, initiation
AK40_106	COG0529	Catalyzes the synthesis of activated sulfate
AK40_1061	COG1649	PFAM Uncharacterised BCR, COG1649
AK40_1066	COG2971	BadF BadG BcrA BcrD
AK40_1068	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AK40_107	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AK40_1073	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_1078	COG1309	transcriptional regulator
AK40_1082	COG0577	efflux transmembrane transporter activity
AK40_1082	COG1136	(ABC) transporter
AK40_1083	COG3615	Tellurite resistance protein tehB
AK40_1083	COG0500	methyltransferase
AK40_1085	COG3961	Belongs to the TPP enzyme family
AK40_1086	COG0582	viral genome integration into host DNA
AK40_1100	COG3961	Belongs to the TPP enzyme family
AK40_1102	COG1846	Transcriptional regulator
AK40_1109	COG2195	Cleaves the N-terminal amino acid of tripeptides
AK40_111	COG1648	precorrin-2 dehydrogenase activity
AK40_1112	COG0110	maltose O-acetyltransferase activity
AK40_1113	COG1686	Belongs to the peptidase S11 family
AK40_1115	COG0768	penicillin binding
AK40_1116	COG1595	DNA-templated transcription, initiation
AK40_1118	COG0768	penicillin binding
AK40_112	COG0733	neurotransmitter:sodium symporter activity
AK40_1120	COG2367	Beta-lactamase
AK40_1122	COG1609	Transcriptional regulator
AK40_1123	COG2814	Major facilitator Superfamily
AK40_1124	COG0673	inositol 2-dehydrogenase activity
AK40_1130	COG3718	enzyme involved in inositol metabolism
AK40_1135	COG0737	Belongs to the 5'-nucleotidase family
AK40_1137	COG0457	Tetratricopeptide repeat
AK40_1138	COG1476	TRANSCRIPTIONal
AK40_1141	COG1876	peptidase activity
AK40_1145	COG1309	transcriptional regulator
AK40_1148	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_1150	COG1252	NADH dehydrogenase
AK40_1151	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK40_1155	COG1960	acyl-CoA dehydrogenase activity
AK40_1156	COG0439	Biotin carboxylase
AK40_1157	COG0511	ligase activity, forming carbon-carbon bonds
AK40_1158	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AK40_1159	COG1024	Enoyl-CoA hydratase
AK40_116	COG1757	Na H antiporter
AK40_1160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AK40_1161	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AK40_1164	COG0572	uridine kinase
AK40_1167	COG2318	DinB family
AK40_1168	COG1686	Belongs to the peptidase S11 family
AK40_1172	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AK40_1176	COG3227	Zinc metalloprotease (Elastase)
AK40_1180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AK40_1180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AK40_1187	COG2226	methyltransferase
AK40_119	COG4758	membrane
AK40_1190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AK40_1194	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_120	COG4585	Histidine kinase
AK40_1203	COG3386	PFAM SMP-30 Gluconolaconase
AK40_1205	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AK40_1206	COG3773	Cell wall hydrolase
AK40_1208	COG0745	RESPONSE REGULATOR receiver
AK40_1209	COG2205	protein histidine kinase activity
AK40_121	COG2197	response regulator
AK40_1214	COG1136	(ABC) transporter
AK40_1215	COG0577	efflux transmembrane transporter activity
AK40_1219	COG0460	homoserine dehydrogenase
AK40_1220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_1222	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AK40_123	COG1114	Component of the transport system for branched-chain amino acids
AK40_1239	COG2124	cytochrome p450
AK40_1246	COG0561	phosphatase activity
AK40_1247	COG5002	protein histidine kinase activity
AK40_1249	COG1819	glycosyl
AK40_125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AK40_1250	COG1794	racemase activity, acting on amino acids and derivatives
AK40_1255	COG2205	protein histidine kinase activity
AK40_1257	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK40_1258	COG0604	alcohol dehydrogenase
AK40_1259	COG0671	phosphoesterase, PA-phosphatase related
AK40_1262	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_1264	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK40_1271	COG0693	protein deglycase activity
AK40_1272	COG0456	acetyltransferase
AK40_1276	COG2814	Major facilitator Superfamily
AK40_1280	COG0584	glycerophosphoryl diester phosphodiesterase
AK40_1284	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_1285	COG0697	spore germination
AK40_1292	COG2223	nitrite transmembrane transporter activity
AK40_1293	COG2816	NAD+ diphosphatase activity
AK40_1294	COG0592	DNA-directed DNA polymerase activity
AK40_1295	COG1051	belongs to the nudix hydrolase family
AK40_13	COG0235	Class ii aldolase
AK40_1300	COG0406	alpha-ribazole phosphatase activity
AK40_1301	COG3878	Protein conserved in bacteria
AK40_1306	COG4667	esterase of the alpha-beta hydrolase superfamily
AK40_1311	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AK40_1314	COG0322	excinuclease ABC activity
AK40_1321	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK40_1326	COG1011	Hydrolase
AK40_133	COG0730	response to heat
AK40_1330	COG1523	belongs to the glycosyl hydrolase 13 family
AK40_1331	COG3227	Zinc metalloprotease (Elastase)
AK40_1336	COG0346	lactoylglutathione lyase activity
AK40_1337	COG0201	protein transport
AK40_1339	COG0697	spore germination
AK40_134	COG0306	phosphate transporter
AK40_1340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_1347	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_135	COG1392	Phosphate transport regulator
AK40_1350	COG2959	enzyme of heme biosynthesis
AK40_1351	COG3773	Cell wall hydrolase
AK40_1351	COG3409	Peptidoglycan-binding domain 1 protein
AK40_1357	COG1309	transcriptional regulator
AK40_136	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK40_1362	COG3284	Transcriptional regulator
AK40_1365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_1366	COG1349	DNA-binding transcription factor activity
AK40_1370	COG1959	2 iron, 2 sulfur cluster binding
AK40_1373	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AK40_1374	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK40_1375	COG0022	dehydrogenase e1 component
AK40_1376	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AK40_1378	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_1379	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK40_1379	COG0456	acetyltransferase
AK40_1380	COG0572	uridine kinase
AK40_1382	COG0494	nUDIX hydrolase
AK40_1387	COG4176	ABC-type proline glycine betaine transport system permease component
AK40_1388	COG4175	Glycine betaine
AK40_1388	COG0517	IMP dehydrogenase activity
AK40_139	COG3852	Histidine kinase
AK40_1390	COG0740	serine-type endopeptidase activity
AK40_1393	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AK40_1394	COG2153	protein acetylation
AK40_1395	COG3397	chitin binding
AK40_1397	COG2205	protein histidine kinase activity
AK40_1398	COG2226	methyltransferase
AK40_1399	COG2315	Protein conserved in bacteria
AK40_140	COG1801	Protein of unknown function DUF72
AK40_1400	COG2153	protein acetylation
AK40_1401	COG0658	competence protein
AK40_1401	COG2333	competence protein COMEC
AK40_1411	COG3973	AAA domain
AK40_1414	COG2105	PFAM AIG2 family protein
AK40_1415	COG0514	ATP-dependent DNA helicase (RecQ)
AK40_1419	COG4637	Psort location Cytoplasmic, score
AK40_142	COG0582	viral genome integration into host DNA
AK40_1424	COG3397	chitin binding
AK40_1426	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AK40_1427	COG1115	amino acid carrier protein
AK40_1428	COG1012	belongs to the aldehyde dehydrogenase family
AK40_1429	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AK40_143	COG5002	protein histidine kinase activity
AK40_1431	COG3938	Belongs to the proline racemase family
AK40_1432	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK40_1440	COG0586	Pfam SNARE associated Golgi protein
AK40_1443	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AK40_1444	COG0519	Catalyzes the synthesis of GMP from XMP
AK40_1445	COG4166	transmembrane transport
AK40_1447	COG4948	Mandelate Racemase Muconate Lactonizing
AK40_1456	COG2936	dipeptidyl-peptidase activity
AK40_1457	COG5002	protein histidine kinase activity
AK40_1458	COG0745	RESPONSE REGULATOR receiver
AK40_146	COG0392	lysyltransferase activity
AK40_146	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AK40_1464	COG1164	Oligoendopeptidase f
AK40_1465	COG0531	amino acid
AK40_1466	COG1522	sequence-specific DNA binding
AK40_1467	COG1307	EDD domain protein, DegV family
AK40_1474	COG2814	Major facilitator Superfamily
AK40_1476	COG1664	Polymer-forming cytoskeletal
AK40_1477	COG0789	Transcriptional regulator
AK40_1478	COG4533	DNA binding
AK40_1479	COG0477	Major facilitator Superfamily
AK40_1479	COG2814	Major facilitator Superfamily
AK40_1483	COG2261	transglycosylase associated protein
AK40_1486	COG2226	methyltransferase
AK40_149	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AK40_1492	COG0436	Aminotransferase
AK40_1493	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AK40_1494	COG5146	pantothenate kinase activity
AK40_1495	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AK40_1498	COG1131	(ABC) transporter
AK40_15	COG2861	carbohydrate metabolic process
AK40_150	COG1686	Belongs to the peptidase S11 family
AK40_1507	COG0628	permease
AK40_1509	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AK40_151	COG2715	membrane protein required for spore maturation
AK40_1510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK40_1511	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AK40_1518	COG2746	aminoglycoside 3-N-acetyltransferase activity
AK40_152	COG0700	Nucleoside recognition
AK40_1523	COG0697	spore germination
AK40_1524	COG2318	DinB family
AK40_153	COG1187	pseudouridine synthase activity
AK40_1532	COG0861	Integral membrane protein TerC family
AK40_1533	COG1368	sulfuric ester hydrolase activity
AK40_1534	COG0488	(ABC) transporter
AK40_1536	COG2409	Drug exporters of the RND superfamily
AK40_1536	COG1033	growth of symbiont in host cell
AK40_1537	COG1309	transcriptional regulator
AK40_1540	COG0287	Prephenate dehydrogenase
AK40_1541	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AK40_1543	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AK40_1543	COG1605	Chorismate mutase
AK40_155	COG1333	cytochrome c biogenesis protein
AK40_1551	COG3584	3D domain protein
AK40_1551	COG1388	LysM domain
AK40_1553	COG2610	gluconate transmembrane transporter activity
AK40_1554	COG1024	Enoyl-CoA hydratase
AK40_1556	COG3290	protein histidine kinase activity
AK40_1556	COG3829	transcription factor binding
AK40_156	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AK40_1561	COG1172	Belongs to the binding-protein-dependent transport system permease family
AK40_1562	COG1172	Belongs to the binding-protein-dependent transport system permease family
AK40_1564	COG2390	Transcriptional regulator
AK40_1565	COG1070	Carbohydrate kinase
AK40_157	COG0745	RESPONSE REGULATOR receiver
AK40_1572	COG2329	Antibiotic biosynthesis monooxygenase
AK40_1576	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK40_1579	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK40_158	COG5002	protein histidine kinase activity
AK40_1580	COG4187	Peptidase family M20/M25/M40
AK40_1581	COG1414	Transcriptional regulator
AK40_1582	COG0833	amino acid
AK40_1583	COG1690	Belongs to the RtcB family
AK40_1584	COG3239	Fatty acid desaturase
AK40_1585	COG1785	Belongs to the alkaline phosphatase family
AK40_1587	COG3655	Transcriptional regulator
AK40_159	COG2096	Adenosyltransferase
AK40_1590	COG4377	Putative membrane peptidase family (DUF2324)
AK40_1592	COG3279	Response regulator of the LytR AlgR family
AK40_1594	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_1595	COG0346	lactoylglutathione lyase activity
AK40_1599	COG0714	Associated with various cellular activities
AK40_160	COG4942	peptidase
AK40_1608	COG0463	Glycosyl transferase, family 2
AK40_1610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AK40_1611	COG0753	catalase activity
AK40_1613	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AK40_162	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AK40_1620	COG0778	Nitroreductase
AK40_1621	COG1846	Transcriptional regulator
AK40_1628	COG1725	Transcriptional regulator
AK40_163	COG1141	Ferredoxin
AK40_1631	COG1136	(ABC) transporter
AK40_1631	COG0577	efflux transmembrane transporter activity
AK40_1636	COG2207	Transcriptional regulator
AK40_1637	COG0456	acetyltransferase
AK40_1641	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_1649	COG0730	response to heat
AK40_165	COG0514	ATP-dependent DNA helicase (RecQ)
AK40_1651	COG0833	amino acid
AK40_1653	COG4335	DNA alkylation repair
AK40_166	COG1266	CAAX protease self-immunity
AK40_1662	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AK40_1667	COG1984	allophanate hydrolase subunit 2
AK40_1668	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AK40_1669	COG1414	Transcriptional regulator
AK40_1672	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK40_1673	COG0640	Transcriptional regulator
AK40_1675	COG1960	acyl-CoA dehydrogenase activity
AK40_168	COG1408	metallophosphoesterase
AK40_1685	COG0574	Belongs to the PEP-utilizing enzyme family
AK40_1685	COG3848	Pyruvate phosphate dikinase
AK40_1686	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_1689	COG5577	PFAM Coat F domain
AK40_1691	COG3403	YqcI/YcgG family
AK40_1692	COG1280	lysine exporter protein (LysE YggA)
AK40_1693	COG1113	amino acid transport
AK40_1699	COG1063	alcohol dehydrogenase
AK40_17	COG3852	Histidine kinase
AK40_170	COG4862	establishment of competence for transformation
AK40_1701	COG1027	Aspartate ammonia-lyase
AK40_1702	COG0252	asparaginase activity
AK40_1703	COG1396	sequence-specific DNA binding
AK40_1708	COG5002	protein histidine kinase activity
AK40_171	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AK40_1713	COG2207	Transcriptional regulator
AK40_1714	COG0322	excinuclease ABC activity
AK40_1715	COG0531	amino acid
AK40_1716	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK40_1717	COG0784	Response regulator, receiver
AK40_1718	COG4191	Histidine kinase
AK40_1719	COG2066	Belongs to the glutaminase family
AK40_1721	COG1115	amino acid carrier protein
AK40_1728	COG0737	Belongs to the 5'-nucleotidase family
AK40_1729	COG2329	Antibiotic biosynthesis monooxygenase
AK40_1733	COG0598	Magnesium transport protein CorA
AK40_1740	COG0415	Belongs to the DNA photolyase family
AK40_1748	COG2814	Major facilitator Superfamily
AK40_175	COG0492	ferredoxin-NADP+ reductase activity
AK40_1750	COG0657	acetylesterase activity
AK40_1751	COG0288	reversible hydration of carbon dioxide
AK40_1753	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AK40_1754	COG5609	conserved protein (DUF2294)
AK40_1757	COG0714	Associated with various cellular activities
AK40_1758	COG1575	Belongs to the MenA family. Type 1 subfamily
AK40_1759	COG2267	carboxylic ester hydrolase activity
AK40_176	COG0252	asparaginase activity
AK40_1760	COG4641	Protein conserved in bacteria
AK40_1762	COG1136	(ABC) transporter
AK40_1763	COG0577	efflux transmembrane transporter activity
AK40_1766	COG0803	Belongs to the bacterial solute-binding protein 9 family
AK40_1767	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AK40_1768	COG1121	(ABC) transporter
AK40_1773	COG0798	PFAM Bile acid sodium symporter
AK40_1774	COG0346	lactoylglutathione lyase activity
AK40_1775	COG0640	Transcriptional regulator
AK40_1779	COG0443	Heat shock 70 kDa protein
AK40_1783	COG0346	lactoylglutathione lyase activity
AK40_1788	COG2814	Major facilitator Superfamily
AK40_1793	COG0745	RESPONSE REGULATOR receiver
AK40_1794	COG3850	Histidine kinase
AK40_1794	COG5002	protein histidine kinase activity
AK40_1799	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AK40_18	COG1846	Transcriptional regulator
AK40_1804	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_1805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AK40_1807	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK40_1810	COG2309	aminopeptidase activity
AK40_1812	COG0789	Transcriptional regulator
AK40_1813	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AK40_1817	COG0577	efflux transmembrane transporter activity
AK40_1820	COG5002	protein histidine kinase activity
AK40_1820	COG3850	Histidine kinase
AK40_1822	COG2364	Membrane
AK40_1823	COG1846	Transcriptional regulator
AK40_1824	COG0456	acetyltransferase
AK40_1825	COG2808	Putative FMN-binding domain
AK40_1826	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_1829	COG1619	proteins homologs of microcin C7 resistance protein MccF
AK40_1832	COG1252	NADH dehydrogenase
AK40_1833	COG3227	Zinc metalloprotease (Elastase)
AK40_1834	COG0584	glycerophosphoryl diester phosphodiesterase
AK40_1841	COG0738	Major facilitator superfamily
AK40_1842	COG0673	inositol 2-dehydrogenase activity
AK40_1843	COG0561	phosphatase activity
AK40_1844	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AK40_1845	COG1609	Transcriptional regulator
AK40_1846	COG0457	Tetratricopeptide repeat
AK40_1851	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AK40_1863	COG0814	amino acid
AK40_1864	COG1760	l-serine dehydratase
AK40_1865	COG1760	l-serine dehydratase
AK40_1866	COG2184	nucleotidyltransferase activity
AK40_1867	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AK40_1868	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AK40_1870	COG1335	isochorismatase
AK40_1871	COG1522	sequence-specific DNA binding
AK40_1872	COG0531	amino acid
AK40_1876	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AK40_1880	COG0662	Cupin 2, conserved barrel domain protein
AK40_1881	COG2207	Transcriptional regulator
AK40_1881	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_1887	COG5632	N-Acetylmuramoyl-L-alanine amidase
AK40_1887	COG3409	Peptidoglycan-binding domain 1 protein
AK40_1895	COG0477	Major facilitator Superfamily
AK40_1897	COG1846	Transcriptional regulator
AK40_1898	COG2814	Major facilitator Superfamily
AK40_190	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AK40_1901	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AK40_1902	COG1131	(ABC) transporter
AK40_1906	COG2076	Multidrug Resistance protein
AK40_1907	COG1309	transcriptional regulator
AK40_1910	COG2031	fatty acid transporter
AK40_1912	COG2249	NAD(P)H dehydrogenase (quinone) activity
AK40_1919	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AK40_1922	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AK40_1923	COG1288	antiporter activity
AK40_1928	COG0789	Transcriptional regulator
AK40_193	COG0142	geranyltranstransferase activity
AK40_1932	COG3443	Belongs to the bacterial solute-binding protein 9 family
AK40_1932	COG0803	Belongs to the bacterial solute-binding protein 9 family
AK40_1933	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_1934	COG0506	proline dehydrogenase activity
AK40_1936	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AK40_1938	COG2197	response regulator
AK40_1942	COG1733	regulation of RNA biosynthetic process
AK40_1943	COG0778	Nitroreductase
AK40_1947	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_1949	COG1131	(ABC) transporter
AK40_195	COG0142	geranyltranstransferase activity
AK40_1954	COG1011	Hydrolase
AK40_196	COG0105	UTP biosynthetic process
AK40_1962	COG0346	lactoylglutathione lyase activity
AK40_1963	COG1940	carbohydrate kinase activity
AK40_1964	COG0738	Major facilitator superfamily
AK40_1965	COG0110	maltose O-acetyltransferase activity
AK40_1967	COG1136	(ABC) transporter
AK40_1967	COG0577	efflux transmembrane transporter activity
AK40_1969	COG0180	Tryptophanyl-tRNA synthetase
AK40_1971	COG0628	permease
AK40_1975	COG2226	methyltransferase
AK40_1977	COG0477	Major facilitator Superfamily
AK40_1983	COG1253	flavin adenine dinucleotide binding
AK40_1984	COG0789	Transcriptional regulator
AK40_1985	COG0697	spore germination
AK40_1986	COG1357	PFAM Pentapeptide repeats (8 copies)
AK40_1987	COG3813	Protein conserved in bacteria
AK40_1988	COG2706	6-phosphogluconolactonase activity
AK40_1989	COG1070	Carbohydrate kinase
AK40_199	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AK40_1991	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AK40_1992	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AK40_1994	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AK40_1998	COG0814	amino acid
AK40_20	COG2318	DinB family
AK40_200	COG0457	Tetratricopeptide repeat
AK40_2003	COG1393	Belongs to the ArsC family
AK40_2004	COG2188	Transcriptional regulator
AK40_2005	COG0673	inositol 2-dehydrogenase activity
AK40_2008	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_2012	COG0384	phenazine biosynthesis protein PhzF
AK40_2014	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_2017	COG0318	PFAM AMP-dependent synthetase and ligase
AK40_2018	COG2249	NAD(P)H dehydrogenase (quinone) activity
AK40_2019	COG1733	regulation of RNA biosynthetic process
AK40_2023	COG0726	polysaccharide deacetylase
AK40_2025	COG1191	sigma factor activity
AK40_2026	COG1266	CAAX protease self-immunity
AK40_2027	COG1309	transcriptional regulator
AK40_2031	COG3152	Membrane
AK40_204	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AK40_2040	COG1151	hydroxylamine reductase activity
AK40_2043	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_2044	COG3409	Peptidoglycan-binding domain 1 protein
AK40_2044	COG3757	hydrolase, family 25
AK40_2051	COG2072	flavoprotein involved in K transport
AK40_2059	COG1113	amino acid transport
AK40_206	COG4347	Protein of unknown function (DUF1405)
AK40_2060	COG2814	Major facilitator Superfamily
AK40_2066	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AK40_2067	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AK40_2070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_2071	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_2072	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_2073	COG3739	integral membrane protein
AK40_2074	COG0384	phenazine biosynthesis protein PhzF
AK40_2078	COG0583	DNA-binding transcription factor activity
AK40_2082	COG1193	negative regulation of DNA recombination
AK40_2087	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AK40_2088	COG1164	Oligoendopeptidase f
AK40_2089	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK40_209	COG2738	Putative neutral zinc metallopeptidase
AK40_2095	COG0584	glycerophosphoryl diester phosphodiesterase
AK40_2100	COG0640	Transcriptional regulator
AK40_2101	COG0604	alcohol dehydrogenase
AK40_2103	COG0457	Tetratricopeptide repeat
AK40_2105	COG2808	Putative FMN-binding domain
AK40_2106	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK40_2108	COG0385	Bile acid
AK40_2109	COG0277	FAD linked oxidase domain protein
AK40_211	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_2115	COG1216	Glycosyl transferase, family 2
AK40_2116	COG1024	Enoyl-CoA hydratase
AK40_2118	COG1285	pathogenesis
AK40_212	COG1694	Mazg nucleotide pyrophosphohydrolase
AK40_2120	COG2514	catechol 2,3-dioxygenase activity
AK40_2121	COG2720	vancomycin resistance protein
AK40_2126	COG1278	Cold shock
AK40_2128	COG0716	FMN binding
AK40_2136	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_2138	COG0165	Argininosuccinate lyase
AK40_2141	COG4145	pantothenate transmembrane transporter activity
AK40_2143	COG1012	belongs to the aldehyde dehydrogenase family
AK40_2144	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_2146	COG1657	PFAM Prenyltransferase squalene oxidase
AK40_2147	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AK40_2148	COG2962	Rard protein
AK40_2149	COG3326	Membrane
AK40_215	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AK40_2152	COG0489	protein tyrosine kinase activity
AK40_2154	COG0314	molybdopterin synthase activity
AK40_2155	COG0303	'Molybdopterin
AK40_2156	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK40_2157	COG2116	formate transmembrane transporter activity
AK40_2159	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AK40_216	COG0438	transferase activity, transferring glycosyl groups
AK40_2160	COG5609	conserved protein (DUF2294)
AK40_2161	COG2427	Protein of unknown function (DUF1641)
AK40_2162	COG3383	formate dehydrogenase (NAD+) activity
AK40_2164	COG0697	spore germination
AK40_2172	COG2226	methyltransferase
AK40_2173	COG4166	transmembrane transport
AK40_2174	COG4166	transmembrane transport
AK40_2175	COG4166	transmembrane transport
AK40_2176	COG1301	dicarboxylic acid transport
AK40_2177	COG1316	TRANSCRIPTIONal
AK40_2179	COG1595	DNA-templated transcription, initiation
AK40_2183	COG1131	(ABC) transporter
AK40_2185	COG0673	inositol 2-dehydrogenase activity
AK40_2187	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AK40_2188	COG0187	DNA topoisomerase II activity
AK40_2189	COG1832	CoA-binding protein
AK40_2190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AK40_2191	COG0745	RESPONSE REGULATOR receiver
AK40_2195	COG4841	protein insertion into membrane
AK40_2196	COG0824	Thioesterase
AK40_22	COG5002	protein histidine kinase activity
AK40_2202	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK40_2204	COG1132	(ABC) transporter
AK40_2210	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AK40_2212	COG0726	polysaccharide deacetylase
AK40_2216	COG2211	Major facilitator Superfamily
AK40_2218	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AK40_2221	COG0183	Belongs to the thiolase family
AK40_2222	COG0318	PFAM AMP-dependent synthetase and ligase
AK40_2223	COG1268	BioY protein
AK40_2224	COG0318	PFAM AMP-dependent synthetase and ligase
AK40_223	COG1199	ATP-dependent helicase activity
AK40_223	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AK40_2234	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_2236	COG5002	protein histidine kinase activity
AK40_2237	COG0400	carboxylic ester hydrolase activity
AK40_2238	COG0346	lactoylglutathione lyase activity
AK40_2239	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK40_2240	COG0069	glutamate synthase activity
AK40_2241	COG1902	pentaerythritol trinitrate reductase activity
AK40_2242	COG1329	Transcriptional regulator
AK40_2243	COG0010	Belongs to the arginase family
AK40_2248	COG2226	methyltransferase
AK40_2256	COG4846	Membrane protein involved in cytochrome C biogenesis
AK40_2257	COG0785	Cytochrome C biogenesis protein
AK40_2261	COG1131	(ABC) transporter
AK40_2263	COG0583	DNA-binding transcription factor activity
AK40_2265	COG1346	cytolysis
AK40_2269	COG0730	response to heat
AK40_227	COG3935	DnaD domain protein
AK40_2271	COG3409	Peptidoglycan-binding domain 1 protein
AK40_2271	COG5632	N-Acetylmuramoyl-L-alanine amidase
AK40_2274	COG1132	(ABC) transporter
AK40_2275	COG1132	(ABC) transporter
AK40_228	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AK40_2280	COG3639	organic phosphonate transmembrane transporter activity
AK40_2283	COG0737	Belongs to the 5'-nucleotidase family
AK40_2285	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AK40_2289	COG1695	Transcriptional regulator
AK40_2290	COG0174	glutamine synthetase
AK40_2291	COG0789	Transcriptional regulator
AK40_2292	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AK40_2293	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AK40_2294	COG2860	membrane
AK40_2296	COG0464	growth
AK40_230	COG4499	WXG100 protein secretion system (Wss), protein YukC
AK40_230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK40_2302	COG1388	LysM domain
AK40_2302	COG3584	3D domain protein
AK40_2303	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AK40_2303	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AK40_2303	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AK40_2304	COG1105	Belongs to the carbohydrate kinase PfkB family
AK40_2305	COG1349	DNA-binding transcription factor activity
AK40_2306	COG1979	alcohol dehydrogenase
AK40_2307	COG2322	membrane
AK40_2310	COG1113	amino acid transport
AK40_2313	COG1408	metallophosphoesterase
AK40_2314	COG2116	formate transmembrane transporter activity
AK40_2316	COG2217	Heavy metal translocating P-type atpase
AK40_2317	COG2608	mercury ion transmembrane transporter activity
AK40_2318	COG1937	Protein conserved in bacteria
AK40_2320	COG2819	hydrolase of the alpha beta superfamily
AK40_2321	COG1120	ATPase activity
AK40_2322	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_2323	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_2324	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_2325	COG0708	Exodeoxyribonuclease III
AK40_2326	COG2169	Transcriptional regulator
AK40_2327	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AK40_2328	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AK40_2330	COG2364	Membrane
AK40_2333	COG2267	carboxylic ester hydrolase activity
AK40_2334	COG0346	lactoylglutathione lyase activity
AK40_2335	COG3300	MHYT domain
AK40_2335	COG5001	Diguanylate cyclase
AK40_2339	COG1086	Polysaccharide biosynthesis protein
AK40_2345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_2348	COG1404	Belongs to the peptidase S8 family
AK40_2349	COG3773	Cell wall hydrolase
AK40_2352	COG1368	sulfuric ester hydrolase activity
AK40_2353	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AK40_2355	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AK40_2359	COG4550	Control of competence regulator ComK, YlbF/YmcA
AK40_2361	COG1013	pyruvate-flavodoxin oxidoreductase activity
AK40_2362	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AK40_2362	COG0674	pyruvate-flavodoxin oxidoreductase activity
AK40_2364	COG2359	stage V sporulation protein S
AK40_2365	COG1692	metallophosphoesterase
AK40_2370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AK40_2371	COG1426	Protein conserved in bacteria
AK40_2374	COG0300	oxidoreductase activity
AK40_2375	COG0612	Peptidase, M16
AK40_2376	COG0612	Peptidase, M16
AK40_2381	COG2188	Transcriptional regulator
AK40_2382	COG1674	ftsk spoiiie
AK40_2384	COG0740	serine-type endopeptidase activity
AK40_2385	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AK40_2387	COG0527	aspartate kinase activity
AK40_2388	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AK40_2389	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AK40_2390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AK40_2391	COG1873	PFAM PRC-barrel domain
AK40_2392	COG0612	Peptidase, M16
AK40_2393	COG0726	polysaccharide deacetylase
AK40_2396	COG0196	riboflavin kinase activity
AK40_2399	COG1550	Protein conserved in bacteria
AK40_24	COG0720	synthase
AK40_2401	COG1358	cellular component organization or biogenesis
AK40_2402	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AK40_2403	COG0195	Participates in both transcription termination and antitermination
AK40_241	COG0116	Belongs to the methyltransferase superfamily
AK40_2410	COG0750	zinc metalloprotease
AK40_2411	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AK40_2412	COG4589	Belongs to the CDS family
AK40_2415	COG0528	UMP kinase activity
AK40_2421	COG4974	Belongs to the 'phage' integrase family
AK40_2423	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AK40_2424	COG0758	DNA mediated transformation
AK40_2425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AK40_243	COG1199	ATP-dependent helicase activity
AK40_2433	COG1837	Belongs to the UPF0109 family
AK40_2435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AK40_2437	COG0552	protein localization to endoplasmic reticulum
AK40_2438	COG1196	nuclear chromosome segregation
AK40_244	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AK40_2441	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_2442	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AK40_2445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AK40_2446	COG1461	Dihydroxyacetone kinase
AK40_2447	COG1302	Protein conserved in bacteria
AK40_2449	COG1564	THIamine pyrophosphokinase
AK40_2450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AK40_2451	COG1162	GTPase activity
AK40_2452	COG2815	serine threonine protein kinase
AK40_2452	COG0515	serine threonine protein kinase
AK40_2453	COG0631	protein serine/threonine phosphatase activity
AK40_2455	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AK40_2455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AK40_2457	COG0242	peptide deformylase activity
AK40_2458	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AK40_2459	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AK40_246	COG3173	Aminoglycoside phosphotransferase
AK40_2461	COG0194	GDP metabolic process
AK40_2463	COG1561	YicC-like family, N-terminal region
AK40_2464	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AK40_2466	COG0006	proline dipeptidase activity
AK40_247	COG0024	Methionine aminopeptidase
AK40_2470	COG3069	C4-dicarboxylate transmembrane transporter activity
AK40_2478	COG0505	Belongs to the CarA family
AK40_2483	COG0564	pseudouridine synthase activity
AK40_2487	COG3599	regulation of cell shape
AK40_2488	COG2302	S4 RNA-binding domain
AK40_2489	COG0762	integral membrane protein
AK40_249	COG2233	PERMEase
AK40_2491	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AK40_2493	COG1873	PFAM PRC-barrel domain
AK40_2494	COG1191	sigma factor activity
AK40_2495	COG1191	sigma factor activity
AK40_2497	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AK40_2498	COG0849	cell division
AK40_2499	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AK40_250	COG2311	Membrane
AK40_2500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AK40_2501	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AK40_2502	COG0772	Belongs to the SEDS family
AK40_2505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AK40_2506	COG0768	penicillin binding
AK40_2508	COG4839	cell division protein FtsL
AK40_2511	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AK40_2515	COG1399	metal-binding, possibly nucleic acid-binding protein
AK40_2517	COG3480	Lon protease (S16) C-terminal proteolytic domain
AK40_2518	COG1752	Esterase of the alpha-beta hydrolase superfamily
AK40_252	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AK40_2520	COG3314	Sporulation integral membrane protein YlbJ
AK40_2521	COG0742	ribosomal rna small subunit methyltransferase
AK40_2524	COG3679	Belongs to the UPF0342 family
AK40_2525	COG0406	alpha-ribazole phosphatase activity
AK40_2528	COG2340	Cysteine-rich secretory protein family
AK40_2531	COG3336	cytochrome c oxidase
AK40_2538	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AK40_2539	COG0772	Belongs to the SEDS family
AK40_254	COG0456	acetyltransferase
AK40_2541	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AK40_2542	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AK40_2544	COG4896	Protein conserved in bacteria
AK40_2549	COG0483	inositol monophosphate 1-phosphatase activity
AK40_2553	COG1982	Orn Lys Arg decarboxylase major
AK40_2563	COG0022	dehydrogenase e1 component
AK40_2564	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AK40_2566	COG0242	peptide deformylase activity
AK40_2567	COG0561	phosphatase activity
AK40_2569	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AK40_2570	COG0569	domain protein
AK40_2574	COG0583	DNA-binding transcription factor activity
AK40_2575	COG0517	IMP dehydrogenase activity
AK40_2577	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AK40_2579	COG4703	Protein of unknown function (DUF1797)
AK40_2582	COG2200	EAL domain
AK40_2583	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_2584	COG1408	metallophosphoesterase
AK40_2586	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AK40_2593	COG2814	Major facilitator Superfamily
AK40_2597	COG3209	COG3209 Rhs family protein
AK40_2599	COG2205	protein histidine kinase activity
AK40_260	COG0754	glutathionylspermidine amidase activity
AK40_2601	COG0436	Aminotransferase
AK40_2602	COG1609	Transcriptional regulator
AK40_2603	COG3833	ABC-type maltose transport systems, permease component
AK40_2604	COG1175	transmembrane transport
AK40_2605	COG2182	Extracellular solute-binding protein
AK40_2607	COG0366	Alpha amylase catalytic
AK40_2608	COG3842	ATPase activity
AK40_2617	COG0183	Belongs to the thiolase family
AK40_2623	COG1695	Transcriptional regulator
AK40_2624	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_2628	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AK40_2629	COG0436	Aminotransferase
AK40_263	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AK40_2636	COG2084	Dehydrogenase
AK40_2637	COG3706	GGDEF domain
AK40_2638	COG0778	Nitroreductase
AK40_2643	COG1263	PTS System
AK40_2643	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK40_2643	COG2190	(PTS) system
AK40_2644	COG3711	transcriptional antiterminator
AK40_2648	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AK40_2653	COG1547	Domain of unknown function (DUF309)
AK40_2654	COG0456	acetyltransferase
AK40_2655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AK40_2656	COG4086	secreted protein
AK40_2657	COG0561	phosphatase activity
AK40_2658	COG0697	spore germination
AK40_266	COG0454	-acetyltransferase
AK40_2661	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK40_2666	COG0733	neurotransmitter:sodium symporter activity
AK40_2670	COG1686	Belongs to the peptidase S11 family
AK40_2671	COG1725	Transcriptional regulator
AK40_2672	COG1131	(ABC) transporter
AK40_2675	COG1846	Transcriptional regulator
AK40_2678	COG0598	Magnesium transport protein CorA
AK40_2683	COG4974	Belongs to the 'phage' integrase family
AK40_2685	COG0735	belongs to the Fur family
AK40_2686	COG1300	Membrane
AK40_2690	COG0667	Aldo Keto reductase
AK40_2691	COG0656	L-ascorbic acid biosynthetic process
AK40_2692	COG0456	acetyltransferase
AK40_2692	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK40_2694	COG1525	nuclease
AK40_2694	COG4085	toxin activity
AK40_2694	COG0737	Belongs to the 5'-nucleotidase family
AK40_2696	COG0596	Alpha beta hydrolase
AK40_2697	COG2056	Na+-H+ antiporter family
AK40_2698	COG1609	Transcriptional regulator
AK40_2699	COG0456	acetyltransferase
AK40_27	COG4873	Protein conserved in bacteria
AK40_270	COG0328	RNA-DNA hybrid ribonuclease activity
AK40_2700	COG1073	alpha beta
AK40_2703	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AK40_2703	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AK40_2704	COG0307	riboflavin synthase, alpha
AK40_2709	COG4106	trans-aconitate 2-methyltransferase activity
AK40_2710	COG1073	alpha beta
AK40_2710	COG2226	methyltransferase
AK40_2713	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AK40_2716	COG0737	Belongs to the 5'-nucleotidase family
AK40_2718	COG1522	sequence-specific DNA binding
AK40_2722	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AK40_2724	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AK40_2727	COG0300	oxidoreductase activity
AK40_2728	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_2729	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK40_2730	COG1760	l-serine dehydratase
AK40_2731	COG1760	l-serine dehydratase
AK40_2734	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AK40_2736	COG2195	Cleaves the N-terminal amino acid of tripeptides
AK40_2737	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_2739	COG1376	ErfK ybiS ycfS ynhG family protein
AK40_2740	COG4129	membrane
AK40_2741	COG1126	abc transporter atp-binding protein
AK40_2742	COG0765	amino acid transport
AK40_2743	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK40_2746	COG2816	NAD+ diphosphatase activity
AK40_2747	COG0772	Belongs to the SEDS family
AK40_2748	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK40_2749	COG0022	dehydrogenase e1 component
AK40_2750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AK40_2751	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AK40_2753	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AK40_2754	COG0280	phosphate acetyltransferase
AK40_2755	COG3290	protein histidine kinase activity
AK40_2755	COG3829	transcription factor binding
AK40_2757	COG0584	glycerophosphoryl diester phosphodiesterase
AK40_2758	COG3093	addiction module antidote protein HigA
AK40_2760	COG0745	RESPONSE REGULATOR receiver
AK40_2761	COG0750	zinc metalloprotease
AK40_2762	COG0497	DNA recombination
AK40_2764	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AK40_2766	COG0142	geranyltranstransferase activity
AK40_277	COG3403	YqcI/YcgG family
AK40_2771	COG1302	Protein conserved in bacteria
AK40_2772	COG0439	Biotin carboxylase
AK40_2773	COG0511	ligase activity, forming carbon-carbon bonds
AK40_278	COG1280	lysine exporter protein (LysE YggA)
AK40_2782	COG3854	ATPases associated with a variety of cellular activities
AK40_2787	COG0006	proline dipeptidase activity
AK40_2790	COG3872	metal-dependent enzyme
AK40_2791	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AK40_2795	COG1695	Transcriptional regulator
AK40_2798	COG0095	Lipoate-protein ligase
AK40_2799	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK40_2800	COG1609	Transcriptional regulator
AK40_2802	COG2076	Multidrug Resistance protein
AK40_2803	COG2076	Multidrug Resistance protein
AK40_281	COG3162	membrane
AK40_2810	COG1131	(ABC) transporter
AK40_2811	COG1725	Transcriptional regulator
AK40_2817	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AK40_282	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK40_283	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AK40_2830	COG4970	Tfp pilus assembly protein FimT
AK40_2832	COG1459	type II secretion system
AK40_2833	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AK40_2843	COG0646	methionine synthase
AK40_2843	COG1410	methionine synthase
AK40_2844	COG0646	methionine synthase
AK40_2844	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AK40_2845	COG0626	cystathionine gamma-synthase activity
AK40_2846	COG0626	cystathionine gamma-synthase activity
AK40_2849	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_2851	COG1940	carbohydrate kinase activity
AK40_2852	COG4483	Protein conserved in bacteria
AK40_2853	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AK40_2855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AK40_2856	COG0704	Plays a role in the regulation of phosphate uptake
AK40_2857	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AK40_2858	COG0581	inorganic phosphate transmembrane transporter activity
AK40_2859	COG0573	inorganic phosphate transmembrane transporter activity
AK40_2860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AK40_2862	COG0477	Major facilitator Superfamily
AK40_2863	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AK40_2868	COG0735	belongs to the Fur family
AK40_2869	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AK40_2870	COG1121	(ABC) transporter
AK40_2871	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_2877	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AK40_2878	COG2384	SAM-dependent methyltransferase
AK40_2879	COG2010	Cytochrome c
AK40_2880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AK40_2881	COG0358	DNA primase activity
AK40_2883	COG0517	IMP dehydrogenase activity
AK40_2886	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AK40_2887	COG0295	cytidine deaminase activity
AK40_2888	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AK40_289	COG0475	glutathione-regulated potassium exporter activity
AK40_2890	COG1480	7TM receptor with intracellular HD hydrolase
AK40_2891	COG1702	phosphate starvation-inducible protein PhoH
AK40_2894	COG1610	YqeY-like protein
AK40_2896	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AK40_2897	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AK40_290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AK40_2901	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AK40_2903	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AK40_2904	COG1733	regulation of RNA biosynthetic process
AK40_2909	COG1466	dna polymerase III delta subunit
AK40_291	COG0789	Transcriptional regulator
AK40_291	COG4978	Transcriptional regulator
AK40_2911	COG0658	competence protein
AK40_2911	COG2333	competence protein COMEC
AK40_2912	COG2131	deaminase
AK40_2913	COG1596	polysaccharide export
AK40_2913	COG1555	photosystem II stabilization
AK40_2914	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK40_2915	COG2226	methyltransferase
AK40_2916	COG0799	negative regulation of ribosome biogenesis
AK40_2917	COG1713	HD superfamily hydrolase involved in NAD metabolism
AK40_2919	COG1534	Rna-binding protein
AK40_2921	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AK40_2922	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AK40_2925	COG1191	sigma factor activity
AK40_2927	COG1595	DNA-templated transcription, initiation
AK40_2929	COG0778	Nitroreductase
AK40_293	COG2323	membrane
AK40_2930	COG2357	RelA SpoT domain protein
AK40_2932	COG1785	Belongs to the alkaline phosphatase family
AK40_2934	COG2267	carboxylic ester hydrolase activity
AK40_294	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AK40_2940	COG1404	Belongs to the peptidase S8 family
AK40_2941	COG3186	Phenylalanine-4-hydroxylase
AK40_2943	COG2514	catechol 2,3-dioxygenase activity
AK40_2944	COG2259	Doxx family
AK40_2952	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_2954	COG1454	alcohol dehydrogenase
AK40_2954	COG1012	belongs to the aldehyde dehydrogenase family
AK40_2955	COG0626	cystathionine gamma-synthase activity
AK40_2956	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AK40_2961	COG0768	penicillin binding
AK40_2967	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AK40_2973	COG0628	permease
AK40_2977	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AK40_2980	COG1104	cysteine desulfurase activity
AK40_2981	COG1959	2 iron, 2 sulfur cluster binding
AK40_2982	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AK40_2984	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AK40_2986	COG0124	histidyl-tRNA synthetase
AK40_2989	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AK40_2991	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AK40_2991	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AK40_2992	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AK40_2993	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AK40_2993	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AK40_2995	COG2244	polysaccharide biosynthetic process
AK40_2996	COG2323	membrane
AK40_2998	COG1862	Preprotein translocase
AK40_3004	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AK40_3006	COG0697	spore germination
AK40_3007	COG0640	Transcriptional regulator
AK40_3012	COG0157	Belongs to the NadC ModD family
AK40_3013	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AK40_3014	COG1104	cysteine desulfurase activity
AK40_3015	COG1827	regulation of RNA biosynthetic process
AK40_3016	COG2258	MOSC domain
AK40_3017	COG0077	Prephenate dehydratase
AK40_3018	COG0577	efflux transmembrane transporter activity
AK40_3019	COG0577	efflux transmembrane transporter activity
AK40_3020	COG1136	(ABC) transporter
AK40_3021	COG5002	protein histidine kinase activity
AK40_3022	COG0745	RESPONSE REGULATOR receiver
AK40_3024	COG3290	protein histidine kinase activity
AK40_3026	COG2868	ribosomal protein
AK40_3028	COG1530	ribonuclease E activity
AK40_3029	COG1994	Peptidase M50
AK40_3030	COG0739	heme binding
AK40_3031	COG2894	cell division
AK40_3034	COG1792	Involved in formation and maintenance of cell shape
AK40_3035	COG1077	Cell shape determining protein MreB Mrl
AK40_305	COG1923	regulation of RNA biosynthetic process
AK40_3052	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK40_3059	COG4974	Belongs to the 'phage' integrase family
AK40_3063	COG0285	dihydrofolate synthase activity
AK40_3064	COG0525	valine-tRNA ligase activity
AK40_3066	COG1388	LysM domain
AK40_3068	COG0113	porphobilinogen synthase activity
AK40_3069	COG1587	Uroporphyrinogen-III synthase
AK40_307	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AK40_3071	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AK40_3073	COG1846	Transcriptional regulator
AK40_3074	COG1764	response to oxidative stress
AK40_3077	COG0470	DNA polymerase III
AK40_3077	COG1067	ATP-dependent peptidase activity
AK40_308	COG1360	Flagellar Motor Protein
AK40_3087	COG0622	Phosphoesterase
AK40_3088	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AK40_309	COG2201	protein-glutamate methylesterase activity
AK40_3090	COG5401	PFAM Sporulation and spore germination
AK40_3094	COG1309	transcriptional regulator
AK40_3097	COG2197	response regulator
AK40_3098	COG2233	PERMEase
AK40_3099	COG0402	S-adenosylhomocysteine deaminase activity
AK40_310	COG0643	Histidine kinase
AK40_310	COG2198	Histidine kinase
AK40_3101	COG1396	sequence-specific DNA binding
AK40_3102	COG0697	spore germination
AK40_3104	COG1959	2 iron, 2 sulfur cluster binding
AK40_3105	COG1668	transmembrane transport
AK40_3106	COG4152	abc transporter atp-binding protein
AK40_3107	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AK40_3108	COG1360	Flagellar Motor Protein
AK40_3109	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AK40_311	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK40_311	COG1776	CheC inhibitor of MCP methylation
AK40_3110	COG1876	peptidase activity
AK40_3111	COG0824	Thioesterase
AK40_3112	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AK40_3113	COG1053	succinate dehydrogenase
AK40_3114	COG2009	succinate dehydrogenase
AK40_3115	COG1719	4-vinyl reductase, 4VR
AK40_3117	COG3118	belongs to the thioredoxin family
AK40_3118	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AK40_3119	COG2086	electron transfer activity
AK40_3120	COG1024	Enoyl-CoA hydratase
AK40_3121	COG1309	transcriptional regulator
AK40_3122	COG0318	PFAM AMP-dependent synthetase and ligase
AK40_3126	COG2318	DinB family
AK40_3131	COG1131	(ABC) transporter
AK40_3132	COG2205	protein histidine kinase activity
AK40_3133	COG0745	RESPONSE REGULATOR receiver
AK40_3135	COG4895	conserved protein (DUF2196)
AK40_3136	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AK40_3139	COG4509	Sortase family
AK40_314	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AK40_3140	COG1120	ATPase activity
AK40_3143	COG5386	Cell surface protein
AK40_3144	COG5386	Cell surface protein
AK40_3145	COG1114	Component of the transport system for branched-chain amino acids
AK40_3146	COG1187	pseudouridine synthase activity
AK40_3149	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AK40_3149	COG1796	DNA polymerase
AK40_3150	COG1286	toxin biosynthetic process
AK40_3156	COG0017	Asparaginyl-tRNA synthetase
AK40_3157	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK40_3157	COG0072	phenylalanine-tRNA ligase activity
AK40_3159	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AK40_3161	COG1418	mRNA catabolic process
AK40_3168	COG2814	Major facilitator Superfamily
AK40_3169	COG1566	PFAM secretion protein HlyD family protein
AK40_3170	COG1309	transcriptional regulator
AK40_3171	COG1363	Peptidase, m42
AK40_3175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AK40_3176	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AK40_3178	COG1484	DNA-dependent DNA replication
AK40_3179	COG3611	Membrane attachment protein
AK40_318	COG1256	bacterial-type flagellum assembly
AK40_3181	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AK40_3182	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AK40_3183	COG0237	dephospho-CoA kinase activity
AK40_3184	COG1971	Probably functions as a manganese efflux pump
AK40_3185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AK40_3186	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AK40_3186	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AK40_3187	COG5002	protein histidine kinase activity
AK40_3188	COG0745	RESPONSE REGULATOR receiver
AK40_319	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AK40_3193	COG0538	isocitrate dehydrogenase activity
AK40_3194	COG0372	Belongs to the citrate synthase family
AK40_3196	COG0628	permease
AK40_3197	COG3030	protein affecting phage T7 exclusion by the F plasmid
AK40_320	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AK40_3202	COG1725	Transcriptional regulator
AK40_3203	COG0281	malic enzyme
AK40_3204	COG0587	DNA-directed DNA polymerase activity
AK40_3207	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AK40_3211	COG4109	DRTGG domain
AK40_3214	COG0006	proline dipeptidase activity
AK40_3223	COG0662	Cupin 2, conserved barrel domain protein
AK40_3225	COG1476	TRANSCRIPTIONal
AK40_3228	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_3229	COG0589	response to stress
AK40_323	COG1815	bacterial-type flagellum-dependent cell motility
AK40_3231	COG4974	Belongs to the 'phage' integrase family
AK40_324	COG1558	bacterial-type flagellum-dependent cell motility
AK40_3242	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_3246	COG0827	DNA restriction-modification system
AK40_3247	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AK40_3248	COG3874	Sporulation protein YtfJ
AK40_325	COG1677	Flagellar hook-basal body complex protein FliE
AK40_3250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AK40_3251	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AK40_3253	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AK40_3256	COG1104	cysteine desulfurase activity
AK40_3258	COG0583	DNA-binding transcription factor activity
AK40_3259	COG0697	spore germination
AK40_326	COG1766	The M ring may be actively involved in energy transduction
AK40_3260	COG1309	transcriptional regulator
AK40_3261	COG1956	GAF domain-containing protein
AK40_3262	COG0626	cystathionine gamma-synthase activity
AK40_327	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK40_3272	COG1595	DNA-templated transcription, initiation
AK40_3275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AK40_3276	COG0454	-acetyltransferase
AK40_3277	COG0517	IMP dehydrogenase activity
AK40_3278	COG0123	including yeast histone deacetylase and acetoin utilization protein
AK40_3281	COG0745	RESPONSE REGULATOR receiver
AK40_3283	COG0666	response to abiotic stimulus
AK40_329	COG1157	protein secretion by the type III secretion system
AK40_3290	COG1609	Transcriptional regulator
AK40_3291	COG4851	CamS sex pheromone cAM373 precursor
AK40_3292	COG3118	belongs to the thioredoxin family
AK40_3294	COG2309	aminopeptidase activity
AK40_3298	COG0577	efflux transmembrane transporter activity
AK40_3299	COG1136	(ABC) transporter
AK40_33	COG1780	Probably involved in ribonucleotide reductase function
AK40_3302	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_3303	COG1695	Transcriptional regulator
AK40_3307	COG1674	ftsk spoiiie
AK40_3309	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK40_3311	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK40_3312	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AK40_3313	COG1363	Peptidase, m42
AK40_3315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_3318	COG0510	thiamine kinase activity
AK40_3319	COG1523	belongs to the glycosyl hydrolase 13 family
AK40_3321	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AK40_3322	COG1349	DNA-binding transcription factor activity
AK40_3323	COG1187	pseudouridine synthase activity
AK40_3324	COG2244	polysaccharide biosynthetic process
AK40_3325	COG2081	HI0933 family
AK40_3326	COG2814	Major facilitator Superfamily
AK40_3328	COG3832	glyoxalase III activity
AK40_3332	COG1329	Transcriptional regulator
AK40_3337	COG0314	molybdopterin synthase activity
AK40_3338	COG1763	Mo-molybdopterin cofactor biosynthetic process
AK40_3339	COG0303	'Molybdopterin
AK40_3341	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK40_3342	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AK40_3346	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK40_3348	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AK40_3356	COG2814	Major facilitator Superfamily
AK40_3357	COG0475	glutathione-regulated potassium exporter activity
AK40_3358	COG0490	domain, Protein
AK40_3359	COG0582	viral genome integration into host DNA
AK40_336	COG0784	Response regulator, receiver
AK40_336	COG0835	chemotaxis
AK40_3362	COG1136	(ABC) transporter
AK40_3366	COG1242	4 iron, 4 sulfur cluster binding
AK40_3367	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AK40_3370	COG1794	racemase activity, acting on amino acids and derivatives
AK40_3372	COG5504	Zn-dependent protease
AK40_3377	COG2267	carboxylic ester hydrolase activity
AK40_3378	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AK40_3379	COG0671	phosphoesterase, PA-phosphatase related
AK40_338	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AK40_3380	COG0438	transferase activity, transferring glycosyl groups
AK40_3382	COG0521	Mo-molybdopterin cofactor biosynthetic process
AK40_3394	COG0546	phosphoglycolate phosphatase activity
AK40_3395	COG1349	DNA-binding transcription factor activity
AK40_3397	COG5002	protein histidine kinase activity
AK40_3398	COG4191	Histidine kinase
AK40_3399	COG2267	carboxylic ester hydrolase activity
AK40_34	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AK40_340	COG0741	lytic transglycosylase activity
AK40_3400	COG1368	sulfuric ester hydrolase activity
AK40_3403	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AK40_3404	COG1116	anion transmembrane transporter activity
AK40_3405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK40_3408	COG0546	phosphoglycolate phosphatase activity
AK40_3410	COG0494	nUDIX hydrolase
AK40_3415	COG0288	reversible hydration of carbon dioxide
AK40_3417	COG1271	oxidase subunit
AK40_3418	COG1294	oxidase, subunit
AK40_342	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK40_3422	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_3427	COG1842	Phage shock protein A
AK40_343	COG1776	CheC inhibitor of MCP methylation
AK40_343	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK40_3441	COG3859	Proton-coupled thiamine transporter YuaJ
AK40_3442	COG5002	protein histidine kinase activity
AK40_3443	COG0745	RESPONSE REGULATOR receiver
AK40_3449	COG1597	lipid kinase activity
AK40_345	COG1338	Plays a role in the flagellum-specific transport system
AK40_3454	COG0586	Pfam SNARE associated Golgi protein
AK40_3456	COG0577	efflux transmembrane transporter activity
AK40_3457	COG1136	(ABC) transporter
AK40_3458	COG2207	Transcriptional regulator
AK40_3458	COG3708	Transcriptional regulator
AK40_3459	COG0745	RESPONSE REGULATOR receiver
AK40_346	COG1987	bacterial-type flagellum assembly
AK40_3460	COG2205	protein histidine kinase activity
AK40_3461	COG0577	efflux transmembrane transporter activity
AK40_3462	COG0577	efflux transmembrane transporter activity
AK40_3463	COG1136	(ABC) transporter
AK40_3464	COG0577	efflux transmembrane transporter activity
AK40_3471	COG3964	amidohydrolase
AK40_3475	COG4948	Mandelate Racemase Muconate Lactonizing
AK40_3477	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AK40_3478	COG0596	Alpha beta hydrolase
AK40_348	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AK40_3480	COG1169	isochorismate synthase
AK40_3481	COG1575	Belongs to the MenA family. Type 1 subfamily
AK40_3482	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AK40_3483	COG1278	Cold shock
AK40_3487	COG0058	SHG alpha-glucan phosphorylase activity
AK40_3489	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AK40_349	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AK40_3493	COG1404	Belongs to the peptidase S8 family
AK40_3494	COG0039	L-malate dehydrogenase activity
AK40_35	COG1403	HNH endonuclease
AK40_350	COG1419	protein localization to endoplasmic reticulum
AK40_351	COG4786	Flagellar basal body rod
AK40_3513	COG0544	peptidyl-prolyl cis-trans isomerase activity
AK40_352	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AK40_3534	COG1285	pathogenesis
AK40_3536	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AK40_3538	COG2155	Conserved Protein
AK40_3539	COG1098	S1 RNA binding domain
AK40_3540	COG0436	Aminotransferase
AK40_3541	COG1522	sequence-specific DNA binding
AK40_3542	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AK40_3543	COG2267	carboxylic ester hydrolase activity
AK40_3545	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AK40_3549	COG5018	Exonuclease
AK40_3550	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AK40_3553	COG0423	glycine-tRNA ligase activity
AK40_3554	COG2050	protein possibly involved in aromatic compounds catabolism
AK40_3556	COG1268	BioY protein
AK40_3557	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AK40_3558	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AK40_3561	COG3584	3D domain protein
AK40_3564	COG1252	NADH dehydrogenase
AK40_3568	COG3708	Transcriptional regulator
AK40_3571	COG1683	Conserved Protein
AK40_3573	COG0316	Belongs to the HesB IscA family
AK40_3576	COG1252	NADH dehydrogenase
AK40_3577	COG2274	protein secretion by the type I secretion system
AK40_3578	COG0390	transport system, permease component
AK40_3579	COG2824	Alkylphosphonate utilization operon protein PhnA
AK40_3583	COG4837	Protein of unknown function (DUF1462)
AK40_3584	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AK40_3586	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AK40_3587	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AK40_359	COG2329	Antibiotic biosynthesis monooxygenase
AK40_3590	COG1136	(ABC) transporter
AK40_3590	COG0577	efflux transmembrane transporter activity
AK40_3591	COG2249	NAD(P)H dehydrogenase (quinone) activity
AK40_3593	COG0647	UMP catabolic process
AK40_3595	COG2445	Protein of unknown function DUF86
AK40_3596	COG1494	fructose-1,6-bisphosphatase
AK40_3599	COG4470	Protein conserved in bacteria
AK40_36	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AK40_36	COG1372	Participates in initiation and elongation during chromosome replication
AK40_3601	COG0789	Transcriptional regulator
AK40_3602	COG4377	Putative membrane peptidase family (DUF2324)
AK40_3607	COG0739	heme binding
AK40_3609	COG3377	Domain of unknown function (DUF1805)
AK40_3610	COG0737	Belongs to the 5'-nucleotidase family
AK40_3611	COG1695	Transcriptional regulator
AK40_3613	COG0719	Fe-S assembly protein
AK40_3614	COG0822	iron-sulfur transferase activity
AK40_3615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AK40_3616	COG0719	Fe-S assembly protein
AK40_3617	COG0396	ATPase activity
AK40_3618	COG1464	Belongs to the NlpA lipoprotein family
AK40_3619	COG1464	Belongs to the NlpA lipoprotein family
AK40_3620	COG2011	ABC-type metal ion transport system permease component
AK40_3621	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AK40_3623	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK40_3624	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AK40_3626	COG1393	Belongs to the ArsC family
AK40_3636	COG0039	L-malate dehydrogenase activity
AK40_3643	COG1309	transcriptional regulator
AK40_3644	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_3647	COG4555	ABC transporter
AK40_365	COG3842	ATPase activity
AK40_3652	COG1960	acyl-CoA dehydrogenase activity
AK40_3653	COG0183	Belongs to the thiolase family
AK40_3654	COG1024	Enoyl-CoA hydratase
AK40_3654	COG1250	3-hydroxyacyl-CoA dehydrogenase
AK40_3656	COG1686	Belongs to the peptidase S11 family
AK40_3659	COG0011	TIGRFAM Protein of
AK40_366	COG0725	ABC transporter, periplasmic molybdate-binding protein
AK40_3660	COG0840	transmembrane signaling receptor activity
AK40_3664	COG2814	Major facilitator Superfamily
AK40_3665	COG0531	amino acid
AK40_3668	COG0706	membrane insertase activity
AK40_367	COG1177	transmembrane transport
AK40_3670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_3678	COG0586	Pfam SNARE associated Golgi protein
AK40_368	COG1234	tRNA 3'-trailer cleavage
AK40_3680	COG1376	ErfK ybiS ycfS ynhG family protein
AK40_3681	COG0745	RESPONSE REGULATOR receiver
AK40_3682	COG5002	protein histidine kinase activity
AK40_3687	COG0840	transmembrane signaling receptor activity
AK40_3688	COG2151	metal-sulfur cluster biosynthetic enzyme
AK40_3689	COG3227	Zinc metalloprotease (Elastase)
AK40_3690	COG1741	Belongs to the pirin family
AK40_3693	COG0475	glutathione-regulated potassium exporter activity
AK40_3694	COG0490	domain, Protein
AK40_3695	COG1115	amino acid carrier protein
AK40_3696	COG0783	Belongs to the Dps family
AK40_3699	COG1611	Belongs to the LOG family
AK40_37	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AK40_3703	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK40_3704	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK40_3705	COG1115	amino acid carrier protein
AK40_3706	COG1115	amino acid carrier protein
AK40_3707	COG2910	NAD(P)H-binding
AK40_3710	COG0656	L-ascorbic acid biosynthetic process
AK40_3711	COG2814	Major facilitator Superfamily
AK40_3712	COG1733	regulation of RNA biosynthetic process
AK40_3714	COG1252	NADH dehydrogenase
AK40_3715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AK40_3716	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AK40_3718	COG3290	protein histidine kinase activity
AK40_3718	COG0840	transmembrane signaling receptor activity
AK40_3720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AK40_3725	COG0488	(ABC) transporter
AK40_3726	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_3728	COG2814	Major facilitator Superfamily
AK40_373	COG1686	Belongs to the peptidase S11 family
AK40_3730	COG3223	Belongs to the PsiE family
AK40_3738	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AK40_375	COG0406	alpha-ribazole phosphatase activity
AK40_3756	COG3104	oligopeptide transport
AK40_3760	COG0557	exoribonuclease II activity
AK40_3761	COG1647	Serine aminopeptidase, S33
AK40_3762	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AK40_3763	COG1346	cytolysis
AK40_3770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AK40_3773	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AK40_3778	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK40_3781	COG2323	membrane
AK40_3783	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AK40_3785	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AK40_3787	COG1051	belongs to the nudix hydrolase family
AK40_3789	COG0492	ferredoxin-NADP+ reductase activity
AK40_379	COG1846	Transcriptional regulator
AK40_3790	COG0457	Tetratricopeptide repeat
AK40_3791	COG0110	maltose O-acetyltransferase activity
AK40_3795	COG1950	PFAM Membrane protein of
AK40_3797	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AK40_3798	COG0556	nucleotide-excision repair
AK40_38	COG1725	Transcriptional regulator
AK40_3801	COG0789	Transcriptional regulator
AK40_3805	COG2855	membrane
AK40_3806	COG0583	DNA-binding transcription factor activity
AK40_3808	COG0655	NAD(P)H dehydrogenase (quinone) activity
AK40_3809	COG0488	(ABC) transporter
AK40_381	COG0367	asparagine synthase
AK40_3811	COG1132	(ABC) transporter
AK40_3812	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AK40_3813	COG0793	Belongs to the peptidase S41A family
AK40_3813	COG3409	Peptidoglycan-binding domain 1 protein
AK40_3814	COG2177	Part of the ABC transporter FtsEX involved in
AK40_3815	COG2884	Cell division ATP-binding protein ftsE
AK40_3817	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AK40_3819	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AK40_3820	COG1278	Cold shock
AK40_3821	COG1040	competence protein
AK40_3822	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AK40_3823	COG0791	NLP P60 protein
AK40_3823	COG1388	LysM domain
AK40_3824	COG1733	regulation of RNA biosynthetic process
AK40_3825	COG1307	EDD domain protein, DegV family
AK40_3826	COG1739	Uncharacterized protein family UPF0029
AK40_3827	COG1316	TRANSCRIPTIONal
AK40_3828	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AK40_3829	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AK40_3830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AK40_3832	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AK40_3832	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AK40_3836	COG1486	melibiose metabolic process
AK40_3837	COG1447	Phosphotransferase system cellobiose-specific component IIA
AK40_3838	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AK40_3840	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AK40_3844	COG1447	Phosphotransferase system cellobiose-specific component IIA
AK40_3846	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AK40_3847	COG1301	dicarboxylic acid transport
AK40_3849	COG0346	lactoylglutathione lyase activity
AK40_3853	COG1511	domain protein
AK40_3854	COG0583	DNA-binding transcription factor activity
AK40_3855	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AK40_3857	COG1271	oxidase subunit
AK40_3858	COG1294	oxidase, subunit
AK40_3859	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AK40_3861	COG1620	l-lactate permease
AK40_3864	COG2389	metal-binding protein
AK40_3866	COG1368	sulfuric ester hydrolase activity
AK40_3868	COG0791	NLP P60 protein
AK40_3868	COG1388	LysM domain
AK40_3869	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK40_387	COG1802	Transcriptional regulator
AK40_3871	COG1215	transferase activity, transferring glycosyl groups
AK40_3873	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AK40_3874	COG3584	3D domain protein
AK40_3874	COG1388	LysM domain
AK40_3879	COG4715	Zinc finger, swim domain protein
AK40_388	COG0697	spore germination
AK40_3880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AK40_3886	COG1191	sigma factor activity
AK40_3889	COG0577	efflux transmembrane transporter activity
AK40_389	COG0523	cobalamin synthesis protein
AK40_3890	COG1136	(ABC) transporter
AK40_3898	COG0745	RESPONSE REGULATOR receiver
AK40_3899	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AK40_39	COG1131	(ABC) transporter
AK40_390	COG0701	Predicted permease
AK40_3902	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AK40_3903	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AK40_3904	COG1215	transferase activity, transferring glycosyl groups
AK40_3906	COG1216	Glycosyl transferase, family 2
AK40_3906	COG1442	glycosyl transferase family 8
AK40_3910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AK40_3911	COG4464	protein tyrosine phosphatase activity
AK40_3912	COG0489	protein tyrosine kinase activity
AK40_3913	COG3944	biosynthesis protein
AK40_3914	COG0489	protein tyrosine kinase activity
AK40_3917	COG1609	Transcriptional regulator
AK40_3918	COG0739	heme binding
AK40_3921	COG3279	Response regulator of the LytR AlgR family
AK40_3922	COG2385	sporulation resulting in formation of a cellular spore
AK40_3923	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AK40_3925	COG4836	Membrane
AK40_3926	COG1007	ATP synthesis coupled electron transport
AK40_3927	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AK40_3928	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AK40_393	COG1757	Na H antiporter
AK40_3930	COG0839	Belongs to the complex I subunit 6 family
AK40_3934	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AK40_3936	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AK40_3937	COG3300	MHYT domain
AK40_3937	COG5001	Diguanylate cyclase
AK40_394	COG0114	fumarate hydratase activity
AK40_3947	COG0356	it plays a direct role in the translocation of protons across the membrane
AK40_3953	COG0698	ribose 5-phosphate isomerase
AK40_3955	COG2190	(PTS) system
AK40_3956	COG2259	Doxx family
AK40_3957	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AK40_3961	COG0009	L-threonylcarbamoyladenylate synthase
AK40_3964	COG2890	protein-(glutamine-N5) methyltransferase activity
AK40_3965	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AK40_3968	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AK40_3969	COG1494	fructose-1,6-bisphosphatase
AK40_397	COG0534	Mate efflux family protein
AK40_3970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AK40_3973	COG4821	SIS domain
AK40_3977	COG1960	acyl-CoA dehydrogenase activity
AK40_3978	COG1960	acyl-CoA dehydrogenase activity
AK40_3979	COG1250	3-hydroxyacyl-CoA dehydrogenase
AK40_398	COG3340	Belongs to the peptidase S51 family
AK40_3980	COG0183	Belongs to the thiolase family
AK40_3981	COG2181	nitrate reductase activity
AK40_3981	COG0247	lactate metabolic process
AK40_3982	COG3620	sequence-specific DNA binding
AK40_3989	COG1404	Belongs to the peptidase S8 family
AK40_3990	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AK40_3999	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK40_4	COG1840	ABC-type Fe3 transport system, periplasmic component
AK40_4001	COG3300	MHYT domain
AK40_4001	COG5001	Diguanylate cyclase
AK40_4005	COG2197	response regulator
AK40_4006	COG4585	Histidine kinase
AK40_4007	COG0842	Transport permease protein
AK40_4008	COG1131	(ABC) transporter
AK40_4009	COG0024	Methionine aminopeptidase
AK40_4011	COG2234	aminopeptidase activity
AK40_4015	COG1595	DNA-templated transcription, initiation
AK40_4017	COG4506	Protein conserved in bacteria
AK40_4018	COG1619	proteins homologs of microcin C7 resistance protein MccF
AK40_402	COG0785	Cytochrome C biogenesis protein
AK40_4021	COG0010	Belongs to the arginase family
AK40_4022	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AK40_4023	COG2814	Major facilitator Superfamily
AK40_4024	COG0789	Transcriptional regulator
AK40_4025	COG0584	glycerophosphoryl diester phosphodiesterase
AK40_4026	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK40_4028	COG1994	Peptidase M50
AK40_4030	COG1078	dGTPase activity
AK40_4031	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_4032	COG1120	ATPase activity
AK40_4033	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_4034	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_4038	COG0095	Lipoate-protein ligase
AK40_4039	COG0280	phosphate acetyltransferase
AK40_4042	COG3773	Cell wall hydrolase
AK40_4044	COG2363	Small membrane protein
AK40_4046	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AK40_4047	COG2233	PERMEase
AK40_4048	COG0561	phosphatase activity
AK40_4049	COG2814	Major facilitator Superfamily
AK40_4051	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AK40_4052	COG1131	(ABC) transporter
AK40_4053	COG2755	lipolytic protein G-D-S-L family
AK40_4054	COG1609	Transcriptional regulator
AK40_4056	COG0460	homoserine dehydrogenase
AK40_4059	COG1011	Hydrolase
AK40_4062	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AK40_4064	COG2197	response regulator
AK40_4065	COG2203	Gaf domain
AK40_4065	COG4585	Histidine kinase
AK40_4066	COG0351	phosphomethylpyrimidine kinase
AK40_4067	COG3706	GGDEF domain
AK40_4068	COG2879	small protein
AK40_4069	COG1966	Carbon starvation protein
AK40_4070	COG3279	Response regulator of the LytR AlgR family
AK40_4071	COG0477	Major facilitator Superfamily
AK40_4076	COG0840	transmembrane signaling receptor activity
AK40_4078	COG1607	acyl-coa hydrolase
AK40_4081	COG0488	(ABC) transporter
AK40_4085	COG0463	Glycosyl transferase, family 2
AK40_4086	COG1309	transcriptional regulator
AK40_4087	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AK40_4088	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AK40_4088	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AK40_4089	COG0628	permease
AK40_409	COG2733	membrane
AK40_4092	COG3279	Response regulator of the LytR AlgR family
AK40_4093	COG3275	phosphorelay sensor kinase activity
AK40_4094	COG2814	Major facilitator Superfamily
AK40_4095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AK40_4096	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AK40_4097	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AK40_41	COG1131	(ABC) transporter
AK40_4101	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AK40_4102	COG1272	protein, Hemolysin III
AK40_4107	COG1164	Oligoendopeptidase f
AK40_4113	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AK40_4114	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AK40_4115	COG4853	Protein conserved in bacteria
AK40_4116	COG4863	YycH protein
AK40_4117	COG5002	protein histidine kinase activity
AK40_4118	COG0745	RESPONSE REGULATOR receiver
AK40_4124	COG0305	Participates in initiation and elongation during chromosome replication
AK40_4126	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AK40_4127	COG4241	membrane
AK40_4129	COG0629	single-stranded DNA binding
AK40_4131	COG0012	GTP binding
AK40_4132	COG4481	Protein conserved in bacteria
AK40_4133	COG0668	transmembrane transport
AK40_4135	COG1475	DNA binding
AK40_4136	COG1192	Involved in chromosome partitioning
AK40_4140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AK40_4141	COG1847	R3H domain protein
AK40_4142	COG0706	membrane insertase activity
AK40_4146	COG0592	DNA-directed DNA polymerase activity
AK40_4147	COG2501	S4 domain
AK40_4149	COG0187	DNA topoisomerase II activity
AK40_4150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AK40_4158	COG0516	GMP reductase activity
AK40_4158	COG0517	IMP dehydrogenase activity
AK40_4159	COG1686	Belongs to the peptidase S11 family
AK40_416	COG1131	(ABC) transporter
AK40_4165	COG1428	Deoxynucleoside kinase
AK40_4166	COG1428	Deoxynucleoside kinase
AK40_4167	COG1335	isochorismatase
AK40_4168	COG0590	tRNA wobble adenosine to inosine editing
AK40_4169	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AK40_4181	COG1982	Orn Lys Arg decarboxylase major
AK40_4183	COG0470	DNA polymerase III
AK40_4184	COG1774	PSP1 C-terminal conserved region
AK40_4186	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AK40_4188	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AK40_4189	COG2002	toxin-antitoxin pair type II binding
AK40_419	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK40_4190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK40_4190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK40_4191	COG0084	hydrolase, TatD family'
AK40_4192	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AK40_4195	COG4466	Protein conserved in bacteria
AK40_4198	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AK40_4199	COG0251	oxidation-reduction process
AK40_42	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AK40_420	COG0528	UMP kinase activity
AK40_4202	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AK40_4203	COG0193	aminoacyl-tRNA hydrolase activity
AK40_4205	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AK40_4206	COG2002	toxin-antitoxin pair type II binding
AK40_4207	COG2244	polysaccharide biosynthetic process
AK40_4208	COG3956	TIGRFAM MazG family protein
AK40_4209	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AK40_4213	COG1098	S1 RNA binding domain
AK40_4216	COG2208	phosphoserine phosphatase activity
AK40_4219	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AK40_422	COG1027	Aspartate ammonia-lyase
AK40_4222	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AK40_4223	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AK40_4224	COG0512	Glutamine amidotransferase of anthranilate synthase
AK40_4225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK40_4226	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AK40_4227	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AK40_4228	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AK40_4229	COG1396	sequence-specific DNA binding
AK40_423	COG0281	malic enzyme
AK40_4230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AK40_4237	COG3880	PFAM UvrB UvrC protein
AK40_4239	COG0542	response to heat
AK40_424	COG4191	Histidine kinase
AK40_4240	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AK40_4242	COG4956	integral membrane protein (PIN domain superfamily)
AK40_4246	COG1045	serine acetyltransferase
AK40_4249	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AK40_425	COG0784	Response regulator, receiver
AK40_4250	COG3688	RNA-binding protein containing a PIN domain
AK40_4252	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AK40_4253	COG0250	Participates in transcription elongation, termination and antitermination
AK40_4258	COG2813	Specifically methylates the guanine in position
AK40_426	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AK40_4261	COG1358	cellular component organization or biogenesis
AK40_4282	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AK40_4287	COG0201	protein transport
AK40_4289	COG0024	Methionine aminopeptidase
AK40_429	COG3620	sequence-specific DNA binding
AK40_4291	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AK40_4297	COG1122	ATPase activity
AK40_4298	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AK40_4299	COG0101	tRNA pseudouridine synthase activity
AK40_4303	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK40_4304	COG0489	protein tyrosine kinase activity
AK40_4306	COG2194	sulfuric ester hydrolase activity
AK40_4307	COG0726	polysaccharide deacetylase
AK40_4324	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AK40_4325	COG4856	YbbR-like protein
AK40_4333	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AK40_434	COG1051	belongs to the nudix hydrolase family
AK40_4340	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_4341	COG2011	ABC-type metal ion transport system permease component
AK40_4342	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AK40_4343	COG1464	Belongs to the NlpA lipoprotein family
AK40_4346	COG0277	FAD linked oxidase domain protein
AK40_4347	COG2271	Major facilitator Superfamily
AK40_4349	COG2814	Major facilitator Superfamily
AK40_4351	COG0601	transmembrane transport
AK40_4352	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK40_4353	COG0444	Belongs to the ABC transporter superfamily
AK40_4354	COG4608	Belongs to the ABC transporter superfamily
AK40_4355	COG4166	transmembrane transport
AK40_4357	COG2207	Transcriptional regulator
AK40_4359	COG1309	transcriptional regulator
AK40_4361	COG4166	transmembrane transport
AK40_4362	COG4166	transmembrane transport
AK40_4363	COG0656	L-ascorbic acid biosynthetic process
AK40_4364	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK40_4367	COG4149	molybdate abc transporter
AK40_4368	COG0725	ABC transporter, periplasmic molybdate-binding protein
AK40_4369	COG1910	domain protein
AK40_4373	COG0697	spore germination
AK40_4376	COG0204	Acyl-transferase
AK40_4378	COG1609	Transcriptional regulator
AK40_4380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_4385	COG5298	Protein conserved in bacteria
AK40_4389	COG0488	(ABC) transporter
AK40_439	COG1966	Carbon starvation protein
AK40_4392	COG0747	negative chemotaxis
AK40_4393	COG0601	transmembrane transport
AK40_4395	COG0444	Belongs to the ABC transporter superfamily
AK40_4396	COG4608	Belongs to the ABC transporter superfamily
AK40_4397	COG0561	phosphatase activity
AK40_4403	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AK40_4404	COG0179	Fumarylacetoacetate (FAA) hydrolase
AK40_4406	COG0531	amino acid
AK40_4409	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AK40_441	COG0477	Major facilitator Superfamily
AK40_4411	COG0705	Rhomboid family
AK40_4411	COG0457	Tetratricopeptide repeat
AK40_4412	COG4294	response to UV
AK40_4414	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AK40_4415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AK40_4416	COG0864	Transcriptional regulator
AK40_4417	COG2337	Toxic component of a toxin-antitoxin (TA) module
AK40_4418	COG2183	response to ionizing radiation
AK40_442	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK40_4437	COG0802	atpase or kinase
AK40_4438	COG1214	PFAM Peptidase M22, glycoprotease
AK40_4439	COG0456	acetyltransferase
AK40_444	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AK40_4441	COG0488	(ABC) transporter
AK40_4444	COG1266	CAAX protease self-immunity
AK40_4447	COG5444	nuclease activity
AK40_445	COG4166	transmembrane transport
AK40_4450	COG2252	PERMEase
AK40_4452	COG5002	protein histidine kinase activity
AK40_4458	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AK40_446	COG2223	nitrite transmembrane transporter activity
AK40_447	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AK40_4471	COG2205	protein histidine kinase activity
AK40_4472	COG0745	RESPONSE REGULATOR receiver
AK40_4477	COG0697	spore germination
AK40_4483	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AK40_4484	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AK40_4485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AK40_4487	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AK40_4490	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AK40_4492	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AK40_4494	COG0151	Belongs to the GarS family
AK40_4499	COG0210	DNA helicase
AK40_45	COG1522	sequence-specific DNA binding
AK40_450	COG2244	polysaccharide biosynthetic process
AK40_4501	COG4851	CamS sex pheromone cAM373 precursor
AK40_4505	COG1335	isochorismatase
AK40_4507	COG2011	ABC-type metal ion transport system permease component
AK40_4508	COG1464	Belongs to the NlpA lipoprotein family
AK40_451	COG0733	neurotransmitter:sodium symporter activity
AK40_4511	COG0003	Pfam Anion-transporting ATPase
AK40_4512	COG1846	Transcriptional regulator
AK40_4513	COG4682	membrane
AK40_4517	COG1597	lipid kinase activity
AK40_4518	COG0546	phosphoglycolate phosphatase activity
AK40_4519	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AK40_4521	COG1012	belongs to the aldehyde dehydrogenase family
AK40_4522	COG2076	Multidrug Resistance protein
AK40_4523	COG2309	aminopeptidase activity
AK40_4526	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK40_4527	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AK40_4528	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AK40_4529	COG5002	protein histidine kinase activity
AK40_453	COG5566	PFAM Mor transcription activator
AK40_4530	COG4807	Protein conserved in bacteria
AK40_4536	COG1473	amidohydrolase
AK40_454	COG2323	membrane
AK40_4540	COG0450	alkyl hydroperoxide reductase
AK40_4541	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AK40_4543	COG0235	Class ii aldolase
AK40_4544	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_4545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_4546	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_4549	COG0166	Belongs to the GPI family
AK40_4555	COG5002	protein histidine kinase activity
AK40_4559	COG3541	Predicted nucleotidyltransferase
AK40_4560	COG2814	Major facilitator Superfamily
AK40_4561	COG0723	plastoquinol--plastocyanin reductase activity
AK40_4561	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK40_4563	COG0765	amino acid transport
AK40_4564	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK40_4566	COG0840	transmembrane signaling receptor activity
AK40_4567	COG0840	transmembrane signaling receptor activity
AK40_4568	COG0366	Alpha amylase catalytic
AK40_4569	COG2190	(PTS) system
AK40_4569	COG1263	PTS System
AK40_4569	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK40_457	COG2084	Dehydrogenase
AK40_4575	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AK40_4578	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK40_4580	COG1116	anion transmembrane transporter activity
AK40_4581	COG0488	(ABC) transporter
AK40_4592	COG2270	Major facilitator Superfamily
AK40_4599	COG2310	stress, protein
AK40_4600	COG2310	stress, protein
AK40_4601	COG2310	stress, protein
AK40_4602	COG0861	Integral membrane protein TerC family
AK40_4604	COG3853	Toxic anion resistance protein (TelA)
AK40_4607	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AK40_4609	COG1295	ribonuclease BN
AK40_461	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AK40_4610	COG2217	Heavy metal translocating P-type atpase
AK40_4611	COG0697	spore germination
AK40_4615	COG0586	Pfam SNARE associated Golgi protein
AK40_4618	COG3871	stress protein (general stress protein 26)
AK40_4619	COG0387	Pfam Sodium calcium exchanger
AK40_4621	COG0535	radical SAM domain protein
AK40_4625	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AK40_4627	COG0101	tRNA pseudouridine synthase activity
AK40_4629	COG3829	transcription factor binding
AK40_463	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK40_4631	COG0833	amino acid
AK40_4632	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AK40_4637	COG2066	Belongs to the glutaminase family
AK40_4638	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK40_4638	COG1263	PTS System
AK40_4639	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK40_464	COG0028	Belongs to the TPP enzyme family
AK40_4642	COG0463	Glycosyl transferase, family 2
AK40_4644	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AK40_4644	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AK40_4647	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AK40_4651	COG1228	amidohydrolase
AK40_4652	COG1090	epimerase
AK40_4658	COG1988	membrane-bound metal-dependent
AK40_4659	COG1194	a g-specific adenine glycosylase
AK40_466	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AK40_4665	COG1132	(ABC) transporter
AK40_4666	COG4129	membrane
AK40_4667	COG0067	glutamate synthase
AK40_4667	COG0069	glutamate synthase activity
AK40_4667	COG0070	glutamate synthase
AK40_4669	COG4555	ABC transporter
AK40_4673	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AK40_4674	COG0735	belongs to the Fur family
AK40_468	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AK40_47	COG1335	isochorismatase
AK40_4702	COG1132	(ABC) transporter
AK40_4705	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AK40_4706	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AK40_4709	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AK40_4711	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AK40_4714	COG2766	serine protein kinase
AK40_4720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AK40_4722	COG1585	Membrane protein implicated in regulation of membrane protease activity
AK40_4723	COG2268	Band 7 protein
AK40_4725	COG3290	protein histidine kinase activity
AK40_4726	COG4565	transcriptional regulatory protein
AK40_4727	COG2851	Citrate transporter
AK40_473	COG2814	Major facilitator Superfamily
AK40_4731	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AK40_4732	COG0745	RESPONSE REGULATOR receiver
AK40_4733	COG5002	protein histidine kinase activity
AK40_4735	COG4990	cell redox homeostasis
AK40_4737	COG3290	protein histidine kinase activity
AK40_4738	COG4565	transcriptional regulatory protein
AK40_4739	COG3493	citrate carrier protein
AK40_474	COG3384	dioxygenase
AK40_4740	COG0281	malic enzyme
AK40_4743	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_4745	COG5002	protein histidine kinase activity
AK40_4746	COG0745	RESPONSE REGULATOR receiver
AK40_4748	COG0454	-acetyltransferase
AK40_4748	COG0456	acetyltransferase
AK40_4749	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AK40_4750	COG3383	formate dehydrogenase (NAD+) activity
AK40_4751	COG2427	Protein of unknown function (DUF1641)
AK40_4754	COG0531	amino acid
AK40_4755	COG0640	Transcriptional regulator
AK40_4756	COG2217	Heavy metal translocating P-type atpase
AK40_4757	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AK40_4761	COG3227	Zinc metalloprotease (Elastase)
AK40_4765	COG2720	vancomycin resistance protein
AK40_4766	COG1316	TRANSCRIPTIONal
AK40_4767	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK40_4768	COG0346	lactoylglutathione lyase activity
AK40_4769	COG1253	flavin adenine dinucleotide binding
AK40_4770	COG1027	Aspartate ammonia-lyase
AK40_4771	COG1620	l-lactate permease
AK40_4774	COG3104	oligopeptide transport
AK40_4775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_4776	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_4777	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_4779	COG0156	8-amino-7-oxononanoate synthase activity
AK40_478	COG3279	Response regulator of the LytR AlgR family
AK40_4780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AK40_4782	COG4548	von Willebrand factor, type A
AK40_4783	COG0714	Associated with various cellular activities
AK40_4784	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK40_4787	COG0531	amino acid
AK40_4788	COG2188	Transcriptional regulator
AK40_4789	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK40_4789	COG1263	PTS System
AK40_479	COG0427	acetyl-CoA hydrolase
AK40_4790	COG0366	Alpha amylase catalytic
AK40_4793	COG0697	spore germination
AK40_4794	COG4585	Histidine kinase
AK40_4795	COG2197	response regulator
AK40_4796	COG1404	Belongs to the peptidase S8 family
AK40_4799	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AK40_4800	COG1115	amino acid carrier protein
AK40_4801	COG1126	abc transporter atp-binding protein
AK40_4802	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK40_4803	COG0765	amino acid transport
AK40_4804	COG0765	amino acid transport
AK40_4805	COG0833	amino acid
AK40_4808	COG1595	DNA-templated transcription, initiation
AK40_4810	COG2378	regulation of single-species biofilm formation
AK40_4811	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AK40_4812	COG5002	protein histidine kinase activity
AK40_4815	COG0659	secondary active sulfate transmembrane transporter activity
AK40_4818	COG0747	negative chemotaxis
AK40_4820	COG0601	transmembrane transport
AK40_4821	COG4608	Belongs to the ABC transporter superfamily
AK40_4823	COG2271	Major facilitator Superfamily
AK40_4824	COG1846	Transcriptional regulator
AK40_4825	COG0477	Major facilitator Superfamily
AK40_4826	COG1609	Transcriptional regulator
AK40_4827	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AK40_4829	COG1129	ABC transporter
AK40_4830	COG1172	Belongs to the binding-protein-dependent transport system permease family
AK40_4831	COG1879	ABC-type sugar transport system periplasmic component
AK40_4832	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AK40_4835	COG1063	alcohol dehydrogenase
AK40_4838	COG3568	Endonuclease Exonuclease Phosphatase
AK40_4844	COG0840	transmembrane signaling receptor activity
AK40_4845	COG1388	LysM domain
AK40_4845	COG3584	3D domain protein
AK40_4846	COG1476	TRANSCRIPTIONal
AK40_4849	COG3104	oligopeptide transport
AK40_4851	COG1114	Component of the transport system for branched-chain amino acids
AK40_4854	COG1113	amino acid transport
AK40_4855	COG2252	PERMEase
AK40_4858	COG2153	protein acetylation
AK40_486	COG4166	transmembrane transport
AK40_4860	COG0569	domain protein
AK40_4860	COG0475	glutathione-regulated potassium exporter activity
AK40_4863	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AK40_4864	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AK40_4865	COG4990	cell redox homeostasis
AK40_4868	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK40_4869	COG0697	spore germination
AK40_4870	COG0531	amino acid
AK40_4872	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AK40_4873	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AK40_4874	COG1918	ferrous iron import across plasma membrane
AK40_4874	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AK40_4875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AK40_4876	COG0573	inorganic phosphate transmembrane transporter activity
AK40_4877	COG0581	inorganic phosphate transmembrane transporter activity
AK40_4879	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AK40_49	COG1619	proteins homologs of microcin C7 resistance protein MccF
AK40_4904	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AK40_4908	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AK40_4909	COG1116	anion transmembrane transporter activity
AK40_491	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_4910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK40_4911	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AK40_4912	COG0352	thiamine-phosphate diphosphorylase activity
AK40_4913	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK40_4914	COG2104	thiamine diphosphate biosynthetic process
AK40_4916	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK40_4917	COG0351	phosphomethylpyrimidine kinase
AK40_492	COG0745	RESPONSE REGULATOR receiver
AK40_4924	COG2205	protein histidine kinase activity
AK40_4925	COG2814	Major facilitator Superfamily
AK40_4926	COG1846	Transcriptional regulator
AK40_4931	COG0577	efflux transmembrane transporter activity
AK40_4931	COG1136	(ABC) transporter
AK40_4933	COG2252	PERMEase
AK40_4934	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_4937	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AK40_4938	COG1621	beta-fructofuranosidase activity
AK40_4939	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK40_4939	COG1263	PTS System
AK40_4940	COG1609	Transcriptional regulator
AK40_4942	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK40_4943	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AK40_4950	COG0778	Nitroreductase
AK40_4951	COG2719	SpoVR family
AK40_4952	COG0446	pyridine nucleotide-disulphide oxidoreductase
AK40_4953	COG1937	Protein conserved in bacteria
AK40_4954	COG0425	Belongs to the sulfur carrier protein TusA family
AK40_4954	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK40_4955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_4955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK40_4956	COG0425	Belongs to the sulfur carrier protein TusA family
AK40_4957	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK40_4959	COG2210	Belongs to the sulfur carrier protein TusA family
AK40_4960	COG0730	response to heat
AK40_4962	COG1316	TRANSCRIPTIONal
AK40_4963	COG0604	alcohol dehydrogenase
AK40_4964	COG1283	sodium-dependent phosphate transmembrane transporter activity
AK40_4967	COG3711	transcriptional antiterminator
AK40_4967	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AK40_4968	COG1447	Phosphotransferase system cellobiose-specific component IIA
AK40_4969	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AK40_497	COG1914	H( )-stimulated, divalent metal cation uptake system
AK40_4973	COG1388	LysM domain
AK40_4973	COG3584	3D domain protein
AK40_4974	COG0577	efflux transmembrane transporter activity
AK40_4975	COG1136	(ABC) transporter
AK40_4977	COG5522	Integral membrane protein (intg_mem_TP0381)
AK40_4980	COG0577	efflux transmembrane transporter activity
AK40_4981	COG1114	Component of the transport system for branched-chain amino acids
AK40_4982	COG3546	catalase activity
AK40_4989	COG0586	Pfam SNARE associated Golgi protein
AK40_4996	COG0531	amino acid
AK40_4997	COG0475	glutathione-regulated potassium exporter activity
AK40_4999	COG1737	Transcriptional regulator
AK40_5	COG3842	ATPase activity
AK40_50	COG2070	2-Nitropropane dioxygenase
AK40_500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AK40_5001	COG1263	PTS System
AK40_5001	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK40_5004	COG2259	Doxx family
AK40_5008	COG1522	sequence-specific DNA binding
AK40_5010	COG2076	Multidrug Resistance protein
AK40_5011	COG2076	Multidrug Resistance protein
AK40_5012	COG1309	transcriptional regulator
AK40_5013	COG2814	Major facilitator Superfamily
AK40_5015	COG4533	DNA binding
AK40_5016	COG2211	Major facilitator Superfamily
AK40_5018	COG0693	protein deglycase activity
AK40_5019	COG0693	protein deglycase activity
AK40_5019	COG0753	catalase activity
AK40_502	COG0531	amino acid
AK40_5021	COG0531	amino acid
AK40_5024	COG1012	belongs to the aldehyde dehydrogenase family
AK40_5025	COG1132	(ABC) transporter
AK40_5026	COG1132	(ABC) transporter
AK40_5027	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK40_5028	COG0765	amino acid transport
AK40_5029	COG1126	abc transporter atp-binding protein
AK40_5032	COG0189	ligase activity
AK40_5038	COG0028	Belongs to the TPP enzyme family
AK40_5039	COG3527	Alpha-acetolactate decarboxylase
AK40_5041	COG0561	phosphatase activity
AK40_5043	COG3409	Peptidoglycan-binding domain 1 protein
AK40_5043	COG5632	N-Acetylmuramoyl-L-alanine amidase
AK40_5044	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AK40_5047	COG0659	secondary active sulfate transmembrane transporter activity
AK40_5052	COG0653	protein targeting
AK40_5053	COG2244	polysaccharide biosynthetic process
AK40_5055	COG4196	transglutaminase domain protein
AK40_5056	COG4196	transglutaminase domain protein
AK40_5060	COG1024	Enoyl-CoA hydratase
AK40_5065	COG1363	Peptidase, m42
AK40_5068	COG0726	polysaccharide deacetylase
AK40_5069	COG3708	Transcriptional regulator
AK40_5069	COG2207	Transcriptional regulator
AK40_5072	COG4974	Belongs to the 'phage' integrase family
AK40_5076	COG3938	Belongs to the proline racemase family
AK40_5083	COG0601	transmembrane transport
AK40_5084	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK40_5085	COG0444	Belongs to the ABC transporter superfamily
AK40_5086	COG4608	Belongs to the ABC transporter superfamily
AK40_5088	COG1160	GTP binding
AK40_5092	COG0556	nucleotide-excision repair
AK40_5096	COG0477	Major facilitator Superfamily
AK40_5097	COG3290	protein histidine kinase activity
AK40_5098	COG4565	transcriptional regulatory protein
AK40_5099	COG3181	Tripartite tricarboxylate transporter family receptor
AK40_51	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AK40_511	COG0745	RESPONSE REGULATOR receiver
AK40_5110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AK40_5119	COG4978	Transcriptional regulator
AK40_5119	COG0789	Transcriptional regulator
AK40_512	COG2205	protein histidine kinase activity
AK40_5122	COG0305	Participates in initiation and elongation during chromosome replication
AK40_5128	COG0477	Major facilitator Superfamily
AK40_513	COG2390	Transcriptional regulator
AK40_5141	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AK40_5141	COG3320	Male sterility
AK40_5145	COG1183	phosphatidylcholine synthase activity
AK40_515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK40_5151	COG2376	Dihydroxyacetone kinase
AK40_5153	COG2376	Dihydroxyacetone kinase
AK40_5154	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AK40_5155	COG1959	2 iron, 2 sulfur cluster binding
AK40_5158	COG0457	Tetratricopeptide repeat
AK40_516	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AK40_5160	COG3437	response regulator, receiver
AK40_5160	COG2770	Histidine kinase
AK40_5175	COG1191	sigma factor activity
AK40_5177	COG2208	phosphoserine phosphatase activity
AK40_5178	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AK40_5179	COG0784	Response regulator, receiver
AK40_5179	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK40_5179	COG2198	Histidine kinase
AK40_5179	COG2205	protein histidine kinase activity
AK40_5184	COG0393	Putative heavy-metal-binding
AK40_5192	COG0420	3'-5' exonuclease activity
AK40_5193	COG4717	serine-type aminopeptidase activity
AK40_5199	COG0346	lactoylglutathione lyase activity
AK40_5200	COG0346	lactoylglutathione lyase activity
AK40_5201	COG0457	Tetratricopeptide repeat
AK40_5203	COG2267	carboxylic ester hydrolase activity
AK40_5207	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AK40_5208	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AK40_5210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AK40_522	COG0006	proline dipeptidase activity
AK40_5220	COG0477	Major facilitator Superfamily
AK40_5221	COG0477	Major facilitator Superfamily
AK40_5223	COG3973	AAA domain
AK40_5224	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AK40_5228	COG4980	gas vesicle protein
AK40_5229	COG0537	adenosine 5'-monophosphoramidase activity
AK40_523	COG2132	Multicopper oxidase
AK40_5230	COG1131	(ABC) transporter
AK40_5231	COG4473	ABC transporter
AK40_5234	COG1309	transcriptional regulator
AK40_5236	COG3402	PFAM membrane-flanked domain
AK40_5237	COG3428	Bacterial PH domain
AK40_5241	COG1309	transcriptional regulator
AK40_5245	COG3402	PFAM membrane-flanked domain
AK40_5246	COG3428	Bacterial PH domain
AK40_5247	COG2329	Antibiotic biosynthesis monooxygenase
AK40_5248	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK40_5259	COG1309	transcriptional regulator
AK40_5260	COG1511	domain protein
AK40_5264	COG1609	Transcriptional regulator
AK40_5266	COG1234	tRNA 3'-trailer cleavage
AK40_5267	COG0095	Lipoate-protein ligase
AK40_5269	COG0318	PFAM AMP-dependent synthetase and ligase
AK40_5280	COG1309	transcriptional regulator
AK40_5281	COG1073	alpha beta
AK40_5282	COG1408	metallophosphoesterase
AK40_5284	COG1078	dGTPase activity
AK40_5286	COG1595	DNA-templated transcription, initiation
AK40_5287	COG2207	Transcriptional regulator
AK40_5287	COG3708	Transcriptional regulator
AK40_5288	COG2205	protein histidine kinase activity
AK40_5289	COG0745	RESPONSE REGULATOR receiver
AK40_5293	COG0501	Belongs to the peptidase M48B family
AK40_5294	COG0697	spore germination
AK40_5297	COG0497	DNA recombination
AK40_5298	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AK40_5299	COG2224	Isocitrate lyase
AK40_53	COG1696	Membrane protein involved in D-alanine export
AK40_530	COG1114	Component of the transport system for branched-chain amino acids
AK40_5301	COG1278	Cold shock
AK40_5304	COG4903	ComK protein
AK40_5306	COG0398	Pfam SNARE associated Golgi protein
AK40_5318	COG0179	Fumarylacetoacetate (FAA) hydrolase
AK40_532	COG2372	response to copper ion
AK40_532	COG1276	copper resistance
AK40_5323	COG0367	asparagine synthase
AK40_5325	COG0753	catalase activity
AK40_5326	COG0004	ammonium transporteR
AK40_533	COG4549	nuclear export factor GLE1
AK40_5330	COG2996	Protein conserved in bacteria
AK40_5332	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AK40_5334	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_5337	COG0561	phosphatase activity
AK40_5339	COG0542	response to heat
AK40_5341	COG2267	carboxylic ester hydrolase activity
AK40_5344	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK40_5345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AK40_5346	COG5504	Zn-dependent protease
AK40_5348	COG0180	Tryptophanyl-tRNA synthetase
AK40_535	COG0697	spore germination
AK40_5350	COG4166	transmembrane transport
AK40_5351	COG0601	transmembrane transport
AK40_5352	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK40_5353	COG0444	Belongs to the ABC transporter superfamily
AK40_5354	COG4608	Belongs to the ABC transporter superfamily
AK40_5355	COG0534	Mate efflux family protein
AK40_5356	COG4166	transmembrane transport
AK40_5358	COG1393	Belongs to the ArsC family
AK40_5359	COG0861	Integral membrane protein TerC family
AK40_536	COG0583	DNA-binding transcription factor activity
AK40_5360	COG4862	establishment of competence for transformation
AK40_5361	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK40_5363	COG1164	Oligoendopeptidase f
AK40_5366	COG2346	COG2346, Truncated hemoglobins
AK40_5367	COG4116	CYTH
AK40_5369	COG2357	RelA SpoT domain protein
AK40_537	COG1959	2 iron, 2 sulfur cluster binding
AK40_5370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AK40_5371	COG0564	pseudouridine synthase activity
AK40_5374	COG0772	Belongs to the SEDS family
AK40_5375	COG1216	Glycosyl transferase, family 2
AK40_5379	COG0463	Glycosyl transferase, family 2
AK40_5379	COG0457	Tetratricopeptide repeat
AK40_538	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AK40_5383	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AK40_5386	COG1091	dTDP-4-dehydrorhamnose reductase activity
AK40_539	COG0778	Nitroreductase
AK40_5396	COG2153	protein acetylation
AK40_5398	COG2382	esterase
AK40_5401	COG5492	domain, Protein
AK40_5402	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK40_5404	COG0512	Glutamine amidotransferase of anthranilate synthase
AK40_5404	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AK40_5411	COG1620	l-lactate permease
AK40_5412	COG5634	Uncharacterized conserved protein (DUF2278)
AK40_542	COG0628	permease
AK40_5421	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK40_5423	COG1476	TRANSCRIPTIONal
AK40_543	COG0039	L-malate dehydrogenase activity
AK40_544	COG1231	oxidoreductase activity
AK40_5447	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AK40_545	COG0523	cobalamin synthesis protein
AK40_5450	COG4152	abc transporter atp-binding protein
AK40_5451	COG1668	transmembrane transport
AK40_5454	COG2226	methyltransferase
AK40_5456	COG1686	Belongs to the peptidase S11 family
AK40_5457	COG0681	Belongs to the peptidase S26 family
AK40_5463	COG1012	belongs to the aldehyde dehydrogenase family
AK40_5465	COG1176	ABC-type spermidine putrescine transport system, permease component I
AK40_5466	COG1177	transmembrane transport
AK40_5467	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AK40_5469	COG2409	Drug exporters of the RND superfamily
AK40_5471	COG0564	pseudouridine synthase activity
AK40_5473	COG2340	Cysteine-rich secretory protein family
AK40_5474	COG0247	lactate metabolic process
AK40_5475	COG0277	FAD linked oxidase domain protein
AK40_5476	COG3835	regulator
AK40_5478	COG0745	RESPONSE REGULATOR receiver
AK40_5479	COG5002	protein histidine kinase activity
AK40_548	COG0318	PFAM AMP-dependent synthetase and ligase
AK40_5480	COG2186	Transcriptional regulator
AK40_5484	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AK40_5486	COG2116	formate transmembrane transporter activity
AK40_5487	COG0861	Integral membrane protein TerC family
AK40_5488	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AK40_549	COG2030	dehydratase
AK40_5490	COG2030	dehydratase
AK40_5494	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_5495	COG3243	poly(R)-hydroxyalkanoic acid synthase
AK40_5498	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AK40_550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK40_5501	COG4974	Belongs to the 'phage' integrase family
AK40_5510	COG1484	DNA-dependent DNA replication
AK40_5511	COG3012	SEC-C Motif Domain Protein
AK40_5511	COG1405	negative regulation of cell septum assembly
AK40_552	COG0411	ABC transporter
AK40_5530	COG0464	growth
AK40_5534	COG1388	LysM domain
AK40_5534	COG0791	NLP P60 protein
AK40_5539	COG3344	reverse transcriptase
AK40_554	COG0559	Belongs to the binding-protein-dependent transport system permease family
AK40_5550	COG0592	DNA-directed DNA polymerase activity
AK40_556	COG0583	DNA-binding transcription factor activity
AK40_5576	COG0305	Participates in initiation and elongation during chromosome replication
AK40_5600	COG3693	PFAM glycoside hydrolase, family 10
AK40_562	COG1271	oxidase subunit
AK40_5628	COG1674	ftsk spoiiie
AK40_563	COG1294	oxidase, subunit
AK40_564	COG4988	ABC transporter
AK40_565	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AK40_5651	COG1780	Probably involved in ribonucleotide reductase function
AK40_5661	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AK40_5667	COG4974	Belongs to the 'phage' integrase family
AK40_5672	COG1073	alpha beta
AK40_5673	COG0784	Response regulator, receiver
AK40_5673	COG2205	protein histidine kinase activity
AK40_5674	COG2197	response regulator
AK40_568	COG1619	proteins homologs of microcin C7 resistance protein MccF
AK40_5681	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AK40_569	COG1686	Belongs to the peptidase S11 family
AK40_5705	COG0726	polysaccharide deacetylase
AK40_5706	COG2207	Transcriptional regulator
AK40_5706	COG3708	Transcriptional regulator
AK40_571	COG1388	LysM domain
AK40_571	COG0791	NLP P60 protein
AK40_573	COG1132	(ABC) transporter
AK40_574	COG0745	RESPONSE REGULATOR receiver
AK40_575	COG2205	protein histidine kinase activity
AK40_5753	COG2002	toxin-antitoxin pair type II binding
AK40_5755	COG1923	regulation of RNA biosynthetic process
AK40_577	COG0300	oxidoreductase activity
AK40_5770	COG0546	phosphoglycolate phosphatase activity
AK40_5771	COG2816	NAD+ diphosphatase activity
AK40_5784	COG0653	protein targeting
AK40_5792	COG0653	protein targeting
AK40_5793	COG0210	DNA helicase
AK40_5795	COG0210	DNA helicase
AK40_5796	COG0470	DNA polymerase III
AK40_58	COG0716	FMN binding
AK40_580	COG0726	polysaccharide deacetylase
AK40_5800	COG3104	oligopeptide transport
AK40_5812	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AK40_5834	COG0726	polysaccharide deacetylase
AK40_584	COG0460	homoserine dehydrogenase
AK40_5859	COG5002	protein histidine kinase activity
AK40_5860	COG0745	RESPONSE REGULATOR receiver
AK40_5872	COG0457	Tetratricopeptide repeat
AK40_5874	COG1923	regulation of RNA biosynthetic process
AK40_589	COG1316	TRANSCRIPTIONal
AK40_5906	COG1404	Belongs to the peptidase S8 family
AK40_591	COG0745	RESPONSE REGULATOR receiver
AK40_592	COG5002	protein histidine kinase activity
AK40_5922	COG4712	double-strand break repair protein
AK40_593	COG0726	polysaccharide deacetylase
AK40_595	COG1285	pathogenesis
AK40_5951	COG4962	Type ii secretion system protein e
AK40_596	COG1247	-acetyltransferase
AK40_5964	COG3711	transcriptional antiterminator
AK40_5965	COG2190	(PTS) system
AK40_5965	COG1263	PTS System
AK40_5965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK40_5966	COG2723	6-phospho-beta-galactosidase activity
AK40_598	COG4264	IucA IucC family
AK40_599	COG0318	PFAM AMP-dependent synthetase and ligase
AK40_5992	COG2311	Membrane
AK40_5999	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AK40_6011	COG4974	Belongs to the 'phage' integrase family
AK40_602	COG1082	Xylose isomerase domain protein TIM barrel
AK40_6020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_6021	COG2318	DinB family
AK40_6027	COG1396	sequence-specific DNA binding
AK40_6029	COG0726	polysaccharide deacetylase
AK40_6030	COG0840	transmembrane signaling receptor activity
AK40_6034	COG1396	sequence-specific DNA binding
AK40_6037	COG1131	(ABC) transporter
AK40_604	COG2814	Major facilitator Superfamily
AK40_6040	COG0515	serine threonine protein kinase
AK40_6040	COG2815	serine threonine protein kinase
AK40_605	COG1279	arginine transmembrane transporter activity
AK40_6054	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AK40_606	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_6065	COG4166	transmembrane transport
AK40_6076	COG1192	Involved in chromosome partitioning
AK40_608	COG1752	Esterase of the alpha-beta hydrolase superfamily
AK40_61	COG3173	Aminoglycoside phosphotransferase
AK40_6118	COG0741	lytic transglycosylase activity
AK40_6118	COG0791	NLP P60 protein
AK40_6136	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AK40_6136	COG0551	DNA topoisomerase type I activity
AK40_6148	COG4653	Phage capsid family
AK40_6149	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AK40_615	COG0577	efflux transmembrane transporter activity
AK40_6150	COG2369	cell adhesion
AK40_6151	COG5518	Phage portal protein
AK40_6155	COG5484	DNA packaging
AK40_616	COG2002	toxin-antitoxin pair type II binding
AK40_617	COG1404	Belongs to the peptidase S8 family
AK40_618	COG0640	Transcriptional regulator
AK40_6181	COG1484	DNA-dependent DNA replication
AK40_619	COG0667	Aldo Keto reductase
AK40_6190	COG3617	BRO family, N-terminal domain
AK40_6192	COG1396	sequence-specific DNA binding
AK40_620	COG2814	Major facilitator Superfamily
AK40_6205	COG1192	Involved in chromosome partitioning
AK40_6213	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AK40_6219	COG4974	Belongs to the 'phage' integrase family
AK40_6225	COG4824	toxin secretion phage lysis holin
AK40_6238	COG5484	DNA packaging
AK40_625	COG0840	transmembrane signaling receptor activity
AK40_6262	COG0305	Participates in initiation and elongation during chromosome replication
AK40_6271	COG3561	AntA/AntB antirepressor
AK40_628	COG3949	Membrane
AK40_6287	COG4824	toxin secretion phage lysis holin
AK40_629	COG0783	Belongs to the Dps family
AK40_6312	COG0457	Tetratricopeptide repeat
AK40_632	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AK40_634	COG1231	oxidoreductase activity
AK40_636	COG4989	oxidoreductase activity
AK40_637	COG0523	cobalamin synthesis protein
AK40_638	COG0456	acetyltransferase
AK40_642	COG3443	Belongs to the bacterial solute-binding protein 9 family
AK40_642	COG0803	Belongs to the bacterial solute-binding protein 9 family
AK40_644	COG0702	epimerase
AK40_646	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AK40_648	COG4166	transmembrane transport
AK40_65	COG0534	Mate efflux family protein
AK40_651	COG0406	alpha-ribazole phosphatase activity
AK40_653	COG5337	Spore coat protein CotH
AK40_654	COG1051	belongs to the nudix hydrolase family
AK40_655	COG0586	Pfam SNARE associated Golgi protein
AK40_656	COG2244	polysaccharide biosynthetic process
AK40_658	COG0701	Predicted permease
AK40_659	COG3689	TIGRFAM TIGR03943 family protein
AK40_66	COG1968	undecaprenyl-diphosphatase activity
AK40_660	COG1607	acyl-coa hydrolase
AK40_661	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK40_664	COG0702	epimerase
AK40_665	COG2839	Protein conserved in bacteria
AK40_666	COG1253	flavin adenine dinucleotide binding
AK40_669	COG1114	Component of the transport system for branched-chain amino acids
AK40_670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK40_673	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK40_675	COG1876	peptidase activity
AK40_677	COG0154	amidase activity
AK40_678	COG2211	Major facilitator Superfamily
AK40_681	COG2368	4-hydroxyphenylacetate
AK40_683	COG0196	riboflavin kinase activity
AK40_686	COG0251	oxidation-reduction process
AK40_69	COG1846	Transcriptional regulator
AK40_692	COG1942	4-Oxalocrotonate Tautomerase
AK40_694	COG0561	phosphatase activity
AK40_696	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AK40_700	COG1819	glycosyl
AK40_701	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_702	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_708	COG0456	acetyltransferase
AK40_71	COG1301	dicarboxylic acid transport
AK40_72	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AK40_724	COG3874	Sporulation protein YtfJ
AK40_729	COG2226	methyltransferase
AK40_73	COG4709	membrane
AK40_733	COG1082	Xylose isomerase domain protein TIM barrel
AK40_734	COG0346	lactoylglutathione lyase activity
AK40_737	COG1595	DNA-templated transcription, initiation
AK40_74	COG3874	Sporulation protein YtfJ
AK40_740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AK40_740	COG0426	domain, Protein
AK40_742	COG0386	Belongs to the glutathione peroxidase family
AK40_743	COG1305	Transglutaminase-like
AK40_744	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AK40_745	COG0714	Associated with various cellular activities
AK40_748	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AK40_749	COG1140	nitrate reductase beta subunit
AK40_750	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AK40_751	COG2181	nitrate reductase activity
AK40_752	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AK40_753	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AK40_754	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK40_755	COG0303	'Molybdopterin
AK40_756	COG0314	molybdopterin synthase activity
AK40_758	COG2223	nitrite transmembrane transporter activity
AK40_760	COG1648	precorrin-2 dehydrogenase activity
AK40_762	COG1587	Uroporphyrinogen-III synthase
AK40_762	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AK40_763	COG2146	nitrite reductase [NAD(P)H] activity
AK40_764	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AK40_765	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AK40_772	COG2359	stage V sporulation protein S
AK40_780	COG5632	N-Acetylmuramoyl-L-alanine amidase
AK40_785	COG1418	mRNA catabolic process
AK40_786	COG0488	(ABC) transporter
AK40_789	COG0629	single-stranded DNA binding
AK40_79	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK40_792	COG1413	lyase activity
AK40_795	COG2136	Putative SAM-dependent methyltransferase
AK40_795	COG2521	methyltransferase
AK40_796	COG0018	arginyl-trna synthetase
AK40_80	COG0028	Belongs to the TPP enzyme family
AK40_803	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AK40_804	COG0017	Asparaginyl-tRNA synthetase
AK40_808	COG1674	ftsk spoiiie
AK40_81	COG0440	acetolactate synthase activity
AK40_831	COG1929	Belongs to the glycerate kinase type-1 family
AK40_832	COG0471	metal ion transport
AK40_833	COG0745	RESPONSE REGULATOR receiver
AK40_834	COG3850	Histidine kinase
AK40_834	COG5002	protein histidine kinase activity
AK40_837	COG0733	neurotransmitter:sodium symporter activity
AK40_842	COG2610	gluconate transmembrane transporter activity
AK40_843	COG1454	alcohol dehydrogenase
AK40_844	COG1794	racemase activity, acting on amino acids and derivatives
AK40_846	COG0456	acetyltransferase
AK40_847	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AK40_849	COG1131	(ABC) transporter
AK40_850	COG4473	ABC transporter
AK40_852	COG0546	phosphoglycolate phosphatase activity
AK40_856	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK40_860	COG0768	penicillin binding
AK40_862	COG0204	Acyl-transferase
AK40_863	COG1272	protein, Hemolysin III
AK40_865	COG0805	protein transport
AK40_867	COG1307	EDD domain protein, DegV family
AK40_868	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AK40_869	COG1999	signal sequence binding
AK40_870	COG0071	Belongs to the small heat shock protein (HSP20) family
AK40_871	COG0367	asparagine synthase
AK40_875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_876	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK40_880	COG1335	isochorismatase
AK40_881	COG1051	belongs to the nudix hydrolase family
AK40_883	COG0668	transmembrane transport
AK40_884	COG4585	Histidine kinase
AK40_884	COG2203	Gaf domain
AK40_885	COG2197	response regulator
AK40_886	COG1737	Transcriptional regulator
AK40_887	COG1064	alcohol dehydrogenase
AK40_898	COG1125	glycine betaine transport
AK40_898	COG0517	IMP dehydrogenase activity
AK40_899	COG1174	glycine betaine transport
AK40_906	COG1253	flavin adenine dinucleotide binding
AK40_907	COG1012	belongs to the aldehyde dehydrogenase family
AK40_908	COG5506	Protein of unknown function (DUF1694)
AK40_911	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AK40_912	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AK40_913	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AK40_914	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AK40_915	COG0456	acetyltransferase
AK40_916	COG3829	transcription factor binding
AK40_917	COG1509	lysine 2,3-aminomutase activity
AK40_924	COG0515	serine threonine protein kinase
AK40_924	COG4991	sh3 domain protein
AK40_924	COG3064	Membrane
AK40_925	COG4326	sporulation control protein
AK40_926	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AK40_927	COG0671	phosphoesterase, PA-phosphatase related
AK40_928	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK40_940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AK40_947	COG0300	oxidoreductase activity
AK40_951	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK40_951	COG4499	WXG100 protein secretion system (Wss), protein YukC
AK40_953	COG2814	Major facilitator Superfamily
AK40_954	COG4841	protein insertion into membrane
AK40_955	COG0372	Belongs to the citrate synthase family
AK40_956	COG2079	MmgE PrpD family protein
AK40_957	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AK40_958	COG1960	acyl-CoA dehydrogenase activity
AK40_959	COG2084	Dehydrogenase
AK40_96	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AK40_961	COG1280	lysine exporter protein (LysE YggA)
AK40_962	COG1024	Enoyl-CoA hydratase
AK40_965	COG0420	3'-5' exonuclease activity
AK40_972	COG2223	nitrite transmembrane transporter activity
AK40_973	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_974	COG1169	isochorismate synthase
AK40_975	COG1021	2,3-dihydroxybenzoate-AMP ligase
AK40_976	COG1535	isochorismatase
AK40_976	COG3433	isochorismatase activity
AK40_977	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AK40_978	COG3251	PFAM MbtH domain protein
AK40_979	COG2814	Major facilitator Superfamily
AK40_982	COG0776	regulation of translation
AK40_984	COG2318	DinB family
AK40_986	COG1115	amino acid carrier protein
AK40_989	COG2329	Antibiotic biosynthesis monooxygenase
AK40_99	COG1183	phosphatidylcholine synthase activity
AK40_990	COG1187	pseudouridine synthase activity
AK40_991	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AK40_993	COG1136	(ABC) transporter
AK40_996	COG0596	Alpha beta hydrolase
AK40_997	COG2814	Major facilitator Superfamily