locus-tag class description NT98_10 ENOG4105VCD cytoplasmic protein NT98_1004 ENOG41082BM Transcriptional regulator, arsr family NT98_1005 ENOG4108IPJ Membrane NT98_1007 ENOG4108HUF Transporter NT98_1010 ENOG41061AI Protein of unknown function (DUF2905) NT98_1013 ENOG4105VIE preprotein translocase, subunit YajC NT98_1015 ENOG4108QG2 Membrane NT98_1016 ENOG4105CKP Polysaccharide Biosynthesis Protein NT98_1018 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) NT98_1019 ENOG41076HS cation diffusion facilitator family transporter NT98_102 ENOG4107XC4 flavin reductase domain protein, FMN-binding NT98_1020 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) NT98_1022 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) NT98_1025 ENOG4105CUT histidyl-tRNA synthetase NT98_1027 ENOG4105CUZ uba thif-type nad fad binding protein NT98_1028 ENOG4108VCI transcription factor, rsfa family NT98_1029 ENOG4106F1P AAA ATPase, central domain protein NT98_103 ENOG4108VGI doxx family NT98_1030 ENOG4105D1H recombination factor protein RarA NT98_1032 ENOG4105C3J Cysteine desulfurase NT98_1035 ENOG4105C7H Helicase, RecD TraA family NT98_1036 ENOG41060CR NT98_1039 ENOG4105C02 permease NT98_1045 ENOG4105HHA aminodeoxychorismate lyase NT98_1046 ENOG4108VQJ O-methyltransferase NT98_1047 ENOG4105XYU peptidase (U32 family) NT98_1048 ENOG4105CFP Peptidase U32 NT98_1051 ENOG4107XRG penicillin-binding protein NT98_1057 ENOG4105C28 cystathionine NT98_1058 ENOG4108EKI Dehydrogenase NT98_106 ENOG4108YZG isomerase NT98_1060 ENOG4108V5C ABC transporter NT98_1061 ENOG4105S6R Iron-hydroxamate transporter permease subunit NT98_1069 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase NT98_1071 ENOG4105MIR Phenylalanine 4-monooxygenase NT98_1072 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin NT98_1088 ENOG4108MUZ hydrolase NT98_1090 ENOG4105G6Z alkaline phosphatase NT98_1093 ENOG4108TVJ Nitroreductase NT98_1097 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NT98_11 ENOG4105BZU Histidine kinase NT98_1100 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase NT98_1101 ENOG4105CQW ribosome biogenesis GTPase YqeH NT98_1103 ENOG410812S Rna-binding protein NT98_1105 ENOG4108WF2 Metal Dependent Phosphohydrolase NT98_1107 ENOG4105DXX methyltransferase NT98_1109 ENOG4105KQC Competence protein NT98_111 ENOG41062M3 atp synthase NT98_1110 ENOG4108UK2 deaminase NT98_1111 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 NT98_1113 ENOG4105TQK DNA polymerase iii, delta' subunit NT98_1118 ENOG4105KVH Transcriptional regulator NT98_1119 ENOG4105CSA Coproporphyrinogen iii oxidase NT98_112 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) NT98_1125 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) NT98_1126 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) NT98_1128 ENOG4105KTH gatB Yqey NT98_1129 ENOG41068P3 sporulation protein YqfC NT98_1131 ENOG4105C9A Phoh family NT98_1132 ENOG4105CTJ Metal Dependent Phosphohydrolase NT98_1134 ENOG4107YR5 Diacylglycerol kinase NT98_1135 ENOG4105KG3 cytidine deaminase NT98_1136 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) NT98_1141 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) NT98_1142 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NT98_1145 ENOG4105EGD dinuclear metal center protein, YbgI family NT98_1150 ENOG41069ZM Protein of unknown function (DUF2624) NT98_1151 ENOG4108JYZ YitT family NT98_1152 ENOG4105FDK ABC transporter NT98_1154 ENOG4105N80 Ferric uptake regulator, Fur family NT98_1159 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) NT98_1161 ENOG4107RF6 penicillin-binding protein NT98_1162 ENOG4105PWN phosphate abc transporter NT98_1163 ENOG4105C8U phosphate abc transporter NT98_1164 ENOG4105E2Z phosphate ABC transporter (Permease NT98_1165 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) NT98_1166 ENOG4108UTW Plays a role in the regulation of phosphate uptake NT98_1169 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase NT98_1171 ENOG4105DKQ ROK family NT98_1173 ENOG4105C5X domain protein NT98_1177 ENOG4105C28 cystathionine NT98_1178 ENOG4105C28 cystathionine NT98_1180 ENOG4105C3R Methionine synthase NT98_12 ENOG4105DWF phosphomethylpyrimidine kinase NT98_1210 ENOG4105C0D helicase NT98_1216 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family NT98_1217 ENOG4105CJ1 ABC, transporter NT98_122 ENOG4105BZU Histidine kinase NT98_1224 ENOG41080TC multidrug resistance protein NT98_1229 ENOG4105WZW rhodanese family NT98_123 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain NT98_1230 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) NT98_1239 ENOG4107YBY Hydrolase NT98_1240 ENOG4105CBJ Metal-dependent enzyme NT98_1243 ENOG4105DC7 peptidase M24 NT98_1248 ENOG4105CD2 stage iii sporulation protein aa NT98_1249 ENOG4105KR5 Stage iii sporulation protein NT98_125 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain NT98_1250 ENOG4108CQH stage III sporulation protein AC NT98_1251 ENOG4105KQ4 Stage iii sporulation protein ad NT98_1253 ENOG410644B Stage III sporulation protein af NT98_1258 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase NT98_1259 ENOG4108ZSR alkaline shock protein NT98_126 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) NT98_1264 ENOG4105CTB Polyprenyl synthetase NT98_1266 ENOG4105DX0 Hemolysin A NT98_1268 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) NT98_1269 ENOG4105S1Z Stage IV sporulation protein B NT98_1270 ENOG4107QQR Sporulation NT98_1287 ENOG4105CNU cell division protein FtsK NT98_13 ENOG4105BZU Histidine kinase NT98_131 ENOG4105D65 subunit l NT98_132 ENOG4105C8S subunit m NT98_133 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) NT98_1333 ENOG4105DHF Membrane NT98_1338 ENOG4106AKK s-layer domain-containing protein NT98_1339 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase NT98_134 ENOG4106778 Protein of unknown function (DUF1146) NT98_1342 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase NT98_1343 ENOG4105C6Y Udp-glucose 6-dehydrogenase NT98_1345 ENOG4105DQ6 Transposase NT98_1376 ENOG4105KRN Transcriptional regulator, abrb family NT98_1378 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) NT98_138 ENOG4105CEY Amp-dependent synthetase and ligase NT98_1386 ENOG4108IBT Inherit from COG: transposase NT98_1388 ENOG4105DQ6 Transposase NT98_1389 ENOG4105DQ6 Transposase NT98_139 ENOG4105DY9 regulatoR NT98_1390 ENOG4108MEK Metal-binding protein YodA NT98_1392 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) NT98_1399 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) NT98_14 ENOG4105WH1 Two component transcriptional regulator luxr family NT98_1416 ENOG4105EKQ RNA-directed DNA polymerase NT98_142 ENOG4105FRN stage II sporulation protein NT98_143 ENOG4107BJW polysaccharide deacetylase NT98_1436 ENOG4105EKQ RNA-directed DNA polymerase NT98_144 ENOG4105MT0 Sporulation transcriptional regulator spoiiid NT98_1445 ENOG4106JUT Streptomycin 3''-adenylyltransferase NT98_146 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase NT98_147 ENOG4107RZX Teichoic acid biosynthesis protein NT98_1471 ENOG4108QXE glycerophosphoryl diester phosphodiesterase NT98_1473 ENOG4108JUB Transcriptional regulator NT98_1475 ENOG4107RDP Dehydrogenase NT98_1476 ENOG4105CKM Branched-chain carboxylic acid kinase NT98_1479 ENOG4105CPP Dehydrogenase, E1 component NT98_148 ENOG4107SJB teichoic acid biosynthesis NT98_1480 ENOG4105C7S Dehydrogenase NT98_1482 ENOG4108QY0 Membrane NT98_1484 ENOG4105G7B Protein of unknown function (DUF2992) NT98_1486 ENOG4108HW3 (ABC) transporter NT98_1487 ENOG4105E5Q amino acid AbC transporter NT98_1488 ENOG4105CDA abc transporter atp-binding protein NT98_1489 ENOG4108QEG Membrane NT98_149 ENOG4107SJB teichoic acid biosynthesis NT98_1490 ENOG4108VZI ErfK ybiS ycfS ynhG family protein NT98_1492 ENOG4105D9U N-acetyltransferase NT98_1493 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) NT98_1495 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) NT98_1497 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic NT98_1501 ENOG4105EJQ L-serine dehydratase NT98_1502 ENOG4105II7 pyrroline-5-carboxylate reductase NT98_1503 ENOG41069FQ Metallo-beta-lactamase superfamily NT98_1504 ENOG4108IXY short-chain dehydrogenase reductase NT98_151 ENOG4105EY8 ABC transporter NT98_1515 ENOG4105CGH 5'-nucleotidase NT98_1516 ENOG4105DFD Na H antiporter NT98_1518 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) NT98_1521 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) NT98_1522 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) NT98_1527 ENOG4108R6K riboflavin synthase, subunit alpha NT98_1528 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) NT98_153 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase NT98_1532 ENOG4108YM7 Gcn5-related n-acetyltransferase NT98_1533 ENOG4105ETE Transcriptional regulator (LacI family NT98_1535 ENOG4107SKW Inherit from COG: Alpha beta hydrolase NT98_1539 ENOG4105RHY Pfam:UPF0157 NT98_1541 ENOG4105CPC Aldo Keto reductase NT98_1545 ENOG4105MZ9 stage II sporulation protein m NT98_1546 ENOG4105I3K Ferric uptake regulator, Fur family NT98_1548 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) NT98_1553 ENOG4105D7N magnesium and cobalt transport protein CorA NT98_156 ENOG4108RB3 Capsular polysaccharide biosynthesis protein NT98_1560 ENOG4105DVE abc transporter atp-binding protein NT98_1561 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family NT98_1562 ENOG4105DZ1 carboxypeptidase NT98_1563 ENOG41082AN stage II sporulation protein NT98_1565 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NT98_1566 ENOG4105C8J )-transporter NT98_157 ENOG4105CMR udp-glucose 4-epimerase NT98_1570 ENOG41090VF Stage v sporulation protein ac NT98_1571 ENOG4105CZ3 stage V sporulation protein ad NT98_1573 ENOG4105G6R Stage v sporulation protein ae NT98_1575 ENOG4105J7I hydrolase NT98_1576 ENOG4105PTM secreted protein NT98_1577 ENOG4107ZE5 PPIases accelerate the folding of proteins NT98_158 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NT98_1584 ENOG4105CE4 GlcNAc 6-P deacetylase NT98_1586 ENOG4105FDP GntR family transcriptional regulator NT98_1588 ENOG4105CID antiterminator NT98_1591 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) NT98_1595 ENOG4105BZU Histidine kinase NT98_1597 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase NT98_16 ENOG4108Y4K DNA-binding transcriptional activator NT98_1605 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase NT98_1609 ENOG4105DTD Dehydrogenase NT98_1610 ENOG4105K7K Transcriptional regulator NT98_1617 ENOG4105CHU acetyl-coa acetyltransferase NT98_1618 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) NT98_162 ENOG4105CXY transporter NT98_1626 ENOG4105CG3 alpha amylase, catalytic region NT98_1628 ENOG4107FKK extracellular solute-binding protein family 1 NT98_163 ENOG4105D7V transposase NT98_1630 ENOG4105EG2 ABC transporter, permease NT98_1631 ENOG4105FKQ transcriptional regulator NT98_1632 ENOG4105CHM Aminotransferase NT98_1634 ENOG4108HGU Histidine kinase NT98_1641 ENOG4105D7V transposase NT98_165 ENOG4105C19 ABC transporter NT98_1650 ENOG4105UIN NT98_1652 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) NT98_1655 ENOG4105K6S Short-chain dehydrogenase reductase Sdr NT98_1656 ENOG4105EPM Diguanylate phosphodiesterase NT98_1659 ENOG4107IN1 Protein of unknown function (DUF1797) NT98_166 ENOG4107RBB ABC transporter, permease NT98_1661 ENOG4108XRC Protein of unknown function (DUF458) NT98_1668 ENOG4107ZYR domain protein NT98_1669 ENOG4105CN5 Metallo-Beta-Lactamase NT98_1671 ENOG4108X4Q Hydrolase NT98_1672 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) NT98_1675 ENOG4105CPP Dehydrogenase, E1 component NT98_1685 ENOG4105CXN decarboxylase NT98_1689 ENOG4105ECY inositol monophosphatase NT98_169 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NT98_1691 ENOG4105CI3 gtp-binding protein typa NT98_1692 ENOG4105QA2 NT98_1696 ENOG4108IAB Phoh family NT98_1699 ENOG4105CNI cell division protein FtsW NT98_1700 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) NT98_1709 ENOG4106UY4 Inherit from COG: Scp-like extracellular NT98_1712 ENOG4107TB6 phosphoglycerate mutase NT98_1716 ENOG4106H78 methyltransferase NT98_1717 ENOG4105H20 Sporulation integral membrane protein YlbJ NT98_1719 ENOG4105D78 K07001 NTE family protein NT98_1720 ENOG41063PX domain protein NT98_1722 ENOG4105KNH Nucleic acid-binding protein NT98_1729 ENOG41068DC Essential cell division protein (By similarity) NT98_1730 ENOG4105CJN penicillin-binding protein NT98_1731 ENOG4105CJN penicillin-binding protein NT98_1732 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) NT98_1735 ENOG4105CNI cell division protein FtsW NT98_1736 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) NT98_1738 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) NT98_1739 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) NT98_1740 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) NT98_1742 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NT98_1744 ENOG4105WR5 sporulation protein, YlmC YmxH family NT98_1745 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase NT98_1746 ENOG4105DFA alanine racemase domain protein NT98_1748 ENOG41067XK integral membrane protein NT98_1749 ENOG4105DBK s4 domain protein NT98_175 ENOG4105C0D helicase NT98_1754 ENOG4105C34 Pseudouridine synthase NT98_176 ENOG4105KBK Zinc finger, swim domain protein NT98_1769 ENOG4105DC7 peptidase M24 NT98_1771 ENOG4105F23 Fibronectin-binding protein NT98_1773 ENOG4105DSJ YicC domain protein NT98_1777 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase NT98_1778 ENOG4105C25 Primosomal protein n' NT98_1779 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) NT98_1781 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B NT98_1783 ENOG4108ZF3 Phosphatase NT98_1784 ENOG4105D9P serine threonine protein kinase NT98_1786 ENOG4105DJV ribulose-phosphate 3-epimerase NT98_1787 ENOG4105FJ0 thiamine NT98_1789 ENOG4108ZAA Alkaline-shock protein NT98_1790 ENOG4105DP4 dak2 domain fusion protein ylov NT98_1791 ENOG4105CB5 ATP-dependent DNA helicase recG NT98_1794 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase NT98_1795 ENOG4105CHR reductase NT98_1798 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) NT98_1799 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) NT98_1803 ENOG4105VB6 UPF0109 protein NT98_1808 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) NT98_181 ENOG41069ER domain protein NT98_1811 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha NT98_1812 ENOG4105C79 DNA protecting protein DprA NT98_1813 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) NT98_1815 ENOG4108HE4 integrase family NT98_182 ENOG4105C94 Transporter NT98_1824 ENOG4105KNE Phosphatidate cytidylyltransferase NT98_1826 ENOG4105DZP Membrane-associated zinc metalloprotease NT98_1828 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) NT98_1830 ENOG4105CHV Transcription elongation factor NusA NT98_1831 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination NT98_1832 ENOG4105VHM ribosomal protein NT98_1834 ENOG4105W7A Protein of unknown function (DUF503) NT98_1837 ENOG4105DTN riboflavin biosynthesis protein ribF NT98_184 ENOG4107R8N Glycosyl transferase, family 2 NT98_1841 ENOG4105C1V Peptidase, M16 NT98_1843 ENOG4105E35 Dipicolinate synthase subunit A NT98_1844 ENOG4108S0H Dipicolinic acid synthetase, b subunit NT98_1853 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) NT98_1855 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) NT98_1857 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit NT98_1859 ENOG4107QZI cell division protein FtsK NT98_1860 ENOG4105FDP GntR family transcriptional regulator NT98_1861 ENOG4105DIH basic membrane NT98_1862 ENOG4108JQ9 ABC transporter NT98_1863 ENOG4105UIB (ABC) transporter NT98_1867 ENOG4108RKS Short-chain dehydrogenase reductase Sdr NT98_1868 ENOG4105XZV Protein of unknown function (DUF3243) NT98_1871 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase NT98_1875 ENOG4105D48 metallophosphoesterase NT98_1876 ENOG4105MCT stage V sporulation protein S NT98_1877 ENOG4108IGT Dipeptidase NT98_1878 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein NT98_1879 ENOG4105DQU oxidoreductase, subunit beta NT98_1886 ENOG4105DA5 (ABC) transporter NT98_189 ENOG4105E0M Sulfatase NT98_1891 ENOG4107QHE Choloylglycine hydrolase NT98_1893 ENOG410890F Dynamin family NT98_1894 ENOG4105E0M Sulfatase NT98_1896 ENOG4105F0V Cell wall hydrolase NT98_1899 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C NT98_1900 ENOG4105CS2 ec 3.2.1.21 NT98_1901 ENOG4108S3Y transcriptional regulator NT98_1903 ENOG4107YEI lmbE family NT98_1904 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) NT98_1907 ENOG41067MG lrgb family NT98_1909 ENOG4107ZY0 Phenazine biosynthesis-like protein NT98_191 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) NT98_1915 ENOG4105BZU Histidine kinase NT98_1921 ENOG4105D03 DNA-3-methyladenine glycosylase II NT98_1922 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) NT98_1924 ENOG4105CGK Exodeoxyribonuclease III NT98_1928 ENOG4105E0A ABC, transporter NT98_1929 ENOG4105NIV Esterase NT98_193 ENOG4105DAA L-lactate NT98_1931 ENOG4105VPX protein, conserved in bacteria NT98_1932 ENOG410681U heavy metal transport detoxification protein NT98_1933 ENOG4105C59 p-type ATPase NT98_1935 ENOG4105K70 DNA-binding protein NT98_1936 ENOG4105TMB Formate nitrite transporter NT98_1939 ENOG4105C85 amino acid NT98_1942 ENOG4108SJC Membrane NT98_1943 ENOG4107QW4 alcohol dehydrogenase NT98_1944 ENOG4105E98 transcriptional regulator DeoR family NT98_1945 ENOG4105DE4 1-phosphofructokinase NT98_1946 ENOG4105DM4 PTS System NT98_1947 ENOG41069ER domain protein NT98_1952 ENOG4105DQ6 Transposase NT98_1955 ENOG4106F1P AAA ATPase, central domain protein NT98_1957 ENOG4105EN6 Membrane NT98_1958 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) NT98_1959 ENOG4105CXI aluminum resistance protein NT98_1960 ENOG4105KV4 Transcriptional regulator NT98_1961 ENOG4105C5F glutamine synthetase NT98_1967 ENOG4105K7K Transcriptional regulator NT98_1971 ENOG4108SVB resolvase NT98_1973 ENOG4105CGH 5'-nucleotidase NT98_1974 ENOG4108HW3 (ABC) transporter NT98_1981 ENOG4105BZ1 (ABC) transporter NT98_1982 ENOG4105BZ1 (ABC) transporter NT98_1985 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase NT98_1990 ENOG41067MG lrgb family NT98_1991 ENOG4105VAW lrga family NT98_1992 ENOG4107RSM transcriptional regulator NT98_1994 ENOG4105CJ1 ABC, transporter NT98_1996 ENOG4105CH2 amidohydrolase NT98_1998 ENOG4107QIV Cytochrome c biogenesis protein NT98_2 ENOG4106YBV Methyl-accepting chemotaxis NT98_200 ENOG4107RSM transcriptional regulator NT98_2006 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) NT98_201 ENOG4105ECB domain protein NT98_2011 ENOG4108903 Formimidoylglutamase NT98_2012 ENOG4108VJ1 Transcriptional regulator (CarD family NT98_2013 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase NT98_2014 ENOG4105CBC glutamate synthase NT98_2016 ENOG4105CK7 Sodium proline symporter NT98_2017 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase NT98_2018 ENOG4105FBA Phospholipase Carboxylesterase NT98_2019 ENOG4105BZU Histidine kinase NT98_202 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase NT98_2021 ENOG4107AYK membrAne NT98_2029 ENOG4108IMY Transcriptional regulator NT98_2032 ENOG4105CEY Amp-dependent synthetase and ligase NT98_2033 ENOG4107ZYJ bioY protein NT98_2034 ENOG4107F3J Amp-dependent synthetase and ligase NT98_2038 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) NT98_2040 ENOG4105E5W Transporter NT98_2046 ENOG4108I0Z Aconitate hydratase NT98_2047 ENOG4108JJA ABC, transporter NT98_2049 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen NT98_205 ENOG4105VZJ PTS System NT98_2050 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) NT98_2056 ENOG4105W8X HesB YadR YfhF-family protein NT98_2058 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase NT98_2059 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) NT98_2060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NT98_2061 ENOG4105C0H protease NT98_2062 ENOG4105K4P CoA-binding domain protein NT98_2063 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) NT98_2065 ENOG4105D9R oxidoreductase NT98_2069 ENOG4105CIG ABC transporter NT98_207 ENOG4105VCP PTS System NT98_2072 ENOG4105EMN RNA polymerase sigma factor NT98_2074 ENOG4108KGH TRANSCRIPTIONal NT98_2078 ENOG4105CUZ uba thif-type nad fad binding protein NT98_2087 ENOG4105CUB amino acid NT98_209 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) NT98_2090 ENOG4105E1K spore germination protein NT98_2091 ENOG4108JB9 formate dehydrogenase NT98_2093 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) NT98_2094 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) NT98_2096 ENOG4105TMB Formate nitrite transporter NT98_2097 ENOG4105D06 uba thif-type nad fad binding protein NT98_2098 ENOG4105CVM Molybdenum cofactor synthesis domain protein NT98_2099 ENOG4108ZAF Molybdopterin NT98_21 ENOG4105D6E homoserine dehydrogenase NT98_2101 ENOG4105D1F ATP-binding protein NT98_2104 ENOG410696E Membrane NT98_2105 ENOG4105FR1 rard protein NT98_2107 ENOG4105EWU Squalene--hopene cyclase NT98_2109 ENOG4105CHR reductase NT98_211 ENOG4105CK1 PTS System NT98_2110 ENOG4105C26 Dehydrogenase NT98_2112 ENOG4108IA2 Sodium pantothenate symporter NT98_2115 ENOG4106IQC argininosuccinate lyase NT98_2117 ENOG410904N short-chain dehydrogenase reductase NT98_212 ENOG4105VCP PTS System NT98_2120 ENOG4105M6F mutator MutT protein NT98_2124 ENOG4105VEQ Cold shock protein NT98_2127 ENOG4108R1P NT98_2129 ENOG41073R8 VanW family NT98_213 ENOG4105F8D glycoside hydrolase family 4 NT98_2130 ENOG4108HW4 amino acid AbC transporter NT98_2132 ENOG4105EAB amino acid AbC transporter NT98_2133 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase NT98_2135 ENOG4105D06 uba thif-type nad fad binding protein NT98_2136 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase NT98_2139 ENOG4105KT7 mgtC SapB transporter NT98_2142 ENOG4105BZU Histidine kinase NT98_2147 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity NT98_2148 ENOG41067SE Tetr family transcriptional regulator NT98_2151 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) NT98_2155 ENOG4105CQB FAD linked oxidase domain protein NT98_2156 ENOG4105C09 Bile acid NT98_2160 ENOG410780I phosphoprotein phosphatase activity NT98_2163 ENOG4105CB2 alcohol dehydrogenase NT98_2164 ENOG41082BM Transcriptional regulator, arsr family NT98_2167 ENOG4107VXM glycerophosphoryl diester phosphodiesterase NT98_217 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family NT98_2173 ENOG4108A04 Beta-lactamase NT98_2180 ENOG4105DPN Oligoendopeptidase f NT98_2181 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase NT98_2182 ENOG4105E5K Alpha-amylase NT98_2184 ENOG4105C98 muts2 protein NT98_2188 ENOG4107V2S Transcriptional regulator NT98_219 ENOG4105ESV Glycosyl transferase, family 4 NT98_2190 ENOG4107CUJ Protein of unknown function (DUF2690) NT98_2195 ENOG4105NX3 Membrane NT98_2196 ENOG4105DQ5 transport system permease protein NT98_2197 ENOG4105EHG Permease protein NT98_2198 ENOG4108MES Periplasmic binding protein NT98_220 ENOG4105C6Y Udp-glucose 6-dehydrogenase NT98_2201 ENOG4107R3E Citrate transporter NT98_2203 ENOG4108TN2 lmbE family NT98_2208 ENOG4105CIS alcohol dehydrogenase NT98_2209 ENOG4105K7K Transcriptional regulator NT98_221 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase NT98_2219 ENOG4105H3G oxidoreductase NT98_222 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase NT98_2224 ENOG410751J NT98_2228 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) NT98_223 ENOG4108KGH TRANSCRIPTIONal NT98_2233 ENOG4105KAF membrAne NT98_224 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein NT98_2241 ENOG4108ZJ4 polysaccharide deacetylase NT98_2246 ENOG4105KVH Transcriptional regulator NT98_2247 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein NT98_2249 ENOG4105KNA -acetyltransferase NT98_2251 ENOG4105CHR reductase NT98_2253 ENOG4105JAB phenazine biosynthesis protein, phzf family NT98_226 ENOG4105KVH Transcriptional regulator NT98_2260 ENOG4105D9R oxidoreductase NT98_2261 ENOG4108TZY GntR Family Transcriptional Regulator NT98_2266 ENOG4105C44 Serine transporter NT98_2273 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase NT98_2276 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) NT98_2277 ENOG4105C6Z Gluconate NT98_2278 ENOG4105CMG Carbohydrate kinase NT98_2279 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) NT98_2280 ENOG4105XDF Protein of unknown function (DUF1272) NT98_2281 ENOG4105DDN Pentapeptide repeat-containing protein NT98_2286 ENOG4105FAW cDP-glucose 4,6-dehydratase NT98_2287 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase NT98_229 ENOG41081UC Inherit from COG: Competence protein NT98_2290 ENOG4105C37 (CBS) domain NT98_2296 ENOG4105EV4 Multidrug resistance protein mdtH NT98_2298 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) NT98_230 ENOG4105VEQ Cold shock protein NT98_2306 ENOG4105C31 Tryptophanyl-tRNA synthetase NT98_2308 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) NT98_231 ENOG4105MS2 ribosomal subunit Interface protein NT98_2310 ENOG4108UW5 maltose o-acetyltransferase NT98_2311 ENOG4105DKQ ROK family NT98_2312 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase NT98_2324 ENOG4105CJ1 ABC, transporter NT98_2326 ENOG4108PSK reductase NT98_233 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) NT98_2330 ENOG4105CA9 Pyruvate kinase NT98_2332 ENOG4108RCM Nitroreductase NT98_2333 ENOG4105KVH Transcriptional regulator NT98_2337 ENOG4108Z66 YbaK ebsC protein NT98_2343 ENOG4107TXC Transcriptional regulator NT98_2345 ENOG4108IND Tetr family transcriptional regulator NT98_2346 ENOG4105EQ0 Major Facilitator superfamily NT98_2347 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) NT98_2349 ENOG4108K8S endonuclease I NT98_235 ENOG4105CAK Cell division ATP-binding protein ftsE NT98_2354 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) NT98_236 ENOG4105CRP Part of the ABC transporter FtsEX involved in NT98_2361 ENOG4105DYS nad(p)h dehydrogenase (quinone) NT98_2363 ENOG4105CRW Short chain fatty acid transporter NT98_2365 ENOG4105KBX Transcriptional regulator, TetR family NT98_2366 ENOG4105KPY Small multidrug resistance protein NT98_2367 ENOG4105RXJ NT98_2369 ENOG41069JR NT98_237 ENOG4105CN1 protease NT98_2370 ENOG4105DA5 (ABC) transporter NT98_2374 ENOG4105CZM Major Facilitator NT98_2375 ENOG4107MII Sugar-specific transcriptional regulator TrmB NT98_2378 ENOG4108ISG Major Facilitator NT98_2380 ENOG4105PNM synthesis protein NT98_2381 ENOG4108VXD carboxy-peptidase NT98_2388 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase NT98_239 ENOG4105BZ1 (ABC) transporter NT98_2398 ENOG4108JQ1 Dehydrogenase NT98_24 ENOG41090WU lipolytic protein G-D-S-L family NT98_2402 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A NT98_2405 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) NT98_2407 ENOG4105BZU Histidine kinase NT98_241 ENOG4108WS4 fmn reductase NT98_2410 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) NT98_2414 ENOG4105JQZ Methyltransferase NT98_2418 ENOG4105VZ8 Transcriptional regulator NT98_2423 ENOG4105K6H D-cysteine desulfhydrase NT98_2429 ENOG41062D9 Histidine kinase NT98_243 ENOG4105DUM transcriptional regulator, lysR family NT98_2431 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NT98_2437 ENOG4105C0R drug resistance transporter emrb qaca subfamily NT98_2438 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) NT98_2440 ENOG4105DMQ Methyltransferase NT98_2449 ENOG4108YXU transcriptional regulator AsnC family NT98_2450 ENOG4105CHR reductase NT98_2451 ENOG4105M4P Tetr family transcriptional regulator NT98_2452 ENOG4105F27 Major Facilitator NT98_2453 ENOG4108IG5 Transcriptional regulator NT98_2461 ENOG41085FC arsR family transcriptional regulator NT98_2462 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase NT98_2463 ENOG4105D6J arsenicaL-resistance protein NT98_2466 ENOG4105Z7P Acetyltransferase (GNAT) family NT98_2469 ENOG4105ECQ AraC Family Transcriptional Regulator NT98_2470 ENOG4108NEV two component transcriptional regulator, LytTR family NT98_2471 ENOG4105BZU Histidine kinase NT98_2473 ENOG4105C19 ABC transporter NT98_2475 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase NT98_2479 ENOG4106P55 Transcriptional regulator NT98_2480 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) NT98_2482 ENOG4105C0R drug resistance transporter emrb qaca subfamily NT98_2483 ENOG4105GPN Uncharacterized conserved protein (DUF2294) NT98_2484 ENOG4108TWJ NADH dehydrogenase subunit 5 NT98_2487 ENOG4105F2M alpha beta hydrolase fold-3 domain protein NT98_2491 ENOG4105CVP deoxyribo-dipyrimidine photolyase NT98_2492 ENOG4108606 TspO/MBR family NT98_25 ENOG4105CJ1 ABC, transporter NT98_250 ENOG4107TXC Transcriptional regulator NT98_2507 ENOG4105CHJ isochorismatase hydrolase NT98_2509 ENOG4105CGH 5'-nucleotidase NT98_2516 ENOG4105CSV Glutaminase NT98_2520 ENOG4108Q8B Spore germination protein NT98_2521 ENOG4108NHD germination protein NT98_2522 ENOG4105II7 pyrroline-5-carboxylate reductase NT98_2523 ENOG4105CUB amino acid NT98_2524 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) NT98_2525 ENOG41075H3 AraC family transcriptional regulator NT98_253 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) NT98_2530 ENOG4105BZU Histidine kinase NT98_2532 ENOG4108B31 Spore germination protein NT98_2534 ENOG4108IMY Transcriptional regulator NT98_2535 ENOG4105HDK L-asparaginase NT98_2536 ENOG4108IJ0 Aspartate ammonia-lyase NT98_2538 ENOG4105E2A Dehydrogenase NT98_254 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) NT98_2544 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) NT98_2551 ENOG4105DWD nucleoside recognition domain protein NT98_2555 ENOG4105FDT acyl-CoA dehydrogenase NT98_2557 ENOG4108ZHR arsR family transcriptional regulator NT98_2558 ENOG4108ZRV stage ii sporulation protein p NT98_2559 ENOG4106N3A copper homeostasis protein cutc NT98_256 ENOG41086DT Membrane protein of unknown function NT98_2561 ENOG4107258 Transcriptional regulator NT98_2562 ENOG4105P4J Allophanate hydrolase, subunit 1 NT98_2569 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) NT98_2571 ENOG4107RF6 penicillin-binding protein NT98_2578 ENOG4105F1N DNA alkylation repair NT98_2580 ENOG4108IQI permease NT98_2582 ENOG410635A Membrane NT98_2594 ENOG4108XET gCN5-related N-acetyltransferase NT98_2595 ENOG4108DMH HTH_ARAC NT98_26 ENOG4108TU7 Inherit from COG: (ABC) transporter NT98_260 ENOG4108S4C acetyltransferase NT98_2600 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family NT98_2604 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) NT98_2607 ENOG4105FS7 Transcriptional regulator NT98_2608 ENOG4108TVJ Nitroreductase NT98_2612 ENOG4105CHH sulfate transporter NT98_2613 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA NT98_2615 ENOG4105C7R Atpase associated with various cellular activities aaa_3 NT98_262 ENOG4105C3M thioredoxin reductase NT98_2623 ENOG4105C8Y Acetylornithine aminotransferase NT98_2627 ENOG4105C7R Atpase associated with various cellular activities aaa_3 NT98_2632 ENOG41068WN NT98_2638 ENOG41090T1 Membrane NT98_264 ENOG4108Z4K mutator MutT protein NT98_2641 ENOG4105VMP Transcriptional regulator NT98_2643 ENOG4105G6Z alkaline phosphatase NT98_2645 ENOG4105ECK Fatty Acid Desaturase NT98_2646 ENOG4105E0Y RtcB Protein NT98_2648 ENOG4107258 Transcriptional regulator NT98_2650 ENOG4105II7 pyrroline-5-carboxylate reductase NT98_2657 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) NT98_266 ENOG4105CHW UPF0052 protein NT98_2662 ENOG41061GT Aldolase NT98_2664 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) NT98_2665 ENOG4105DKT Transcriptional regulator NT98_2668 ENOG4105F5R ABC transporter NT98_2669 ENOG4105D4B ABC, transporter NT98_2672 ENOG41069ER domain protein NT98_268 ENOG4105KRI phosphocarrier protein (HPr NT98_2680 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase NT98_2686 ENOG41082JN Transcriptional regulator NT98_2687 ENOG4105EYF MMPL domain protein NT98_269 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) NT98_2696 ENOG4105C5H ABC transporter NT98_2697 ENOG4105E0M Sulfatase NT98_2698 ENOG4108ZCF integral membrane protein NT98_2699 ENOG4106ETB IIa component NT98_270 ENOG4108QY0 Membrane NT98_2701 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC NT98_2703 ENOG4107VMI polysaccharide deacetylase NT98_2704 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase NT98_2709 ENOG4105I4A GCN5-related N-acetyltransferase NT98_2715 ENOG4108AQF aminoglycoside N(3)-acetyltransferase NT98_2719 ENOG4105E09 nadh pyrophosphatase NT98_2722 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein NT98_2723 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component NT98_2724 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) NT98_2726 ENOG4105C02 permease NT98_273 ENOG4105CZ3 stage V sporulation protein ad NT98_2737 ENOG4105DVE abc transporter atp-binding protein NT98_274 ENOG41090VF Stage v sporulation protein ac NT98_2740 ENOG4108ZMI UPF0477 protein NT98_2743 ENOG4105CHM Aminotransferase NT98_2750 ENOG41089UC methyltransferase, type 11 NT98_2753 ENOG4107BMA Transglycosylase associated protein NT98_2758 ENOG4106K7D Major facilitator family transporter NT98_2759 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) NT98_2774 ENOG4105EPR degv family NT98_2777 ENOG4105DVH amino acid NT98_2778 ENOG4105DPN Oligoendopeptidase f NT98_278 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NT98_2782 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 NT98_2787 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NT98_2788 ENOG4105BZU Histidine kinase NT98_2789 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) NT98_2799 ENOG4105DTQ mandelate racemase muconate lactonizing NT98_28 ENOG4105VCH membrane NT98_2804 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD NT98_2807 ENOG4107T5V SNARE associated Golgi NT98_2813 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein NT98_2816 ENOG4105CTU Proline racemase NT98_2817 ENOG4105CTU Proline racemase NT98_2819 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) NT98_2820 ENOG4105C26 Dehydrogenase NT98_2821 ENOG4105BZG amino acid carrier protein NT98_2825 ENOG4108M1A Chitin-binding protein NT98_2835 ENOG4105C9U ATP-dependent DNA helicase RecQ NT98_2839 ENOG4105EEM helicase NT98_284 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) NT98_2843 ENOG4108Z7F N-acetyltransferase NT98_2848 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 NT98_2850 ENOG4105MSB protein, conserved in bacteria NT98_2851 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) NT98_2855 ENOG41087PP glycosyltransferase MGT family NT98_2856 ENOG4108M1A Chitin-binding protein NT98_2857 ENOG41082BV acetyltransferase NT98_2858 ENOG4105E66 phosphoriboisomerase A NT98_2863 ENOG4108IJ7 Glycine betaine NT98_2864 ENOG4107SQ8 Glycine betaine NT98_2870 ENOG4105DBI uridine monophosphokinase NT98_2871 ENOG4105RHY Pfam:UPF0157 NT98_2872 ENOG4105E1F short-chain dehydrogenase reductase NT98_2874 ENOG4107RUY (E1 component), alpha subunit NT98_2876 ENOG4107QKR Dehydrogenase NT98_288 ENOG41067MG lrgb family NT98_2880 ENOG4105E98 transcriptional regulator DeoR family NT98_2883 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family NT98_2887 ENOG4107Z3H Transcriptional regulator, TetR family NT98_289 ENOG4105XZU Preprotein translocase, subunit SecG NT98_2896 ENOG4105MSI germination protein ypeb NT98_29 ENOG410667J hydrolase NT98_2908 ENOG4105CIS alcohol dehydrogenase NT98_291 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) NT98_2911 ENOG4105FDR Membrane NT98_2913 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) NT98_2914 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) NT98_2917 ENOG4108IUM Glycogen debranching enzyme NT98_2918 ENOG4108IUM Glycogen debranching enzyme NT98_2919 ENOG4108IUM Glycogen debranching enzyme NT98_2923 ENOG4105U0R haloacid dehalogenase-like hydrolase NT98_2929 ENOG4107VFR oxidoreductase NT98_2939 ENOG4107Y9U Membrane NT98_2940 ENOG4107Y9U Membrane NT98_2944 ENOG4105EGD dinuclear metal center protein, YbgI family NT98_2949 ENOG4105FCD Major Facilitator NT98_2952 ENOG4105E09 nadh pyrophosphatase NT98_2953 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) NT98_2954 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) NT98_2955 ENOG4108Z4K mutator MutT protein NT98_2960 ENOG4108XI2 Domain of unknown function (DUF1963) NT98_2964 ENOG4108NRW Phospholipase, patatin family NT98_2965 ENOG4105KWG Pfam:DUF1696 NT98_297 ENOG4105CM4 permease protein NT98_2973 ENOG4105PKS Excinuclease abc c subunit domain protein NT98_298 ENOG4108IPW abc transporter atp-binding protein NT98_2993 ENOG4107VXM glycerophosphoryl diester phosphodiesterase NT98_2994 ENOG4107VXM glycerophosphoryl diester phosphodiesterase NT98_3 ENOG4105EN6 Membrane NT98_3002 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase NT98_3003 ENOG4105F27 Major Facilitator NT98_3006 ENOG4108V4B ThiJ pfpI NT98_3013 ENOG4105CJN penicillin-binding protein NT98_3014 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase NT98_3015 ENOG4105CB2 alcohol dehydrogenase NT98_3016 ENOG4105GR3 Histidine kinase NT98_3019 ENOG4105RHY Pfam:UPF0157 NT98_3022 ENOG4108HGU Histidine kinase NT98_3029 ENOG4105BZU Histidine kinase NT98_303 ENOG4108MK9 spermidine N(1)-acetyltransferase NT98_3030 ENOG410667J hydrolase NT98_304 ENOG4105C5H ABC transporter NT98_3048 ENOG4105ETU transcriptional activator (TenA NT98_3052 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family NT98_3053 ENOG4105D6E homoserine dehydrogenase NT98_3069 ENOG4108VKI Cell wall hydrolase NT98_3070 ENOG4105DK7 lysyl-tRNA synthetase NT98_3072 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein NT98_3074 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) NT98_3076 ENOG410900G Protein of unknown function (DUF421) NT98_3080 ENOG4105EFA 4-hydroxyphenylacetate NT98_3081 ENOG4105EFA 4-hydroxyphenylacetate NT98_3087 ENOG4105CUV Homoserine Kinase NT98_309 ENOG4105WMR Protein CrcB homolog NT98_3091 ENOG41089UC methyltransferase, type 11 NT98_3093 ENOG4107Y80 Major Facilitator superfamily NT98_31 ENOG4107SVH Potassium channel protein NT98_3101 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) NT98_3103 ENOG4105T9C HD domain NT98_311 ENOG4105C8Q Methyl-accepting chemotaxis NT98_3110 ENOG4105DBI uridine monophosphokinase NT98_3114 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) NT98_3115 ENOG4107QX3 carboxylase NT98_3116 ENOG4105E39 Enoyl-CoA hydratase NT98_3117 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase NT98_3118 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit NT98_3119 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase NT98_3120 ENOG4105C1G acyl-Coa dehydrogenase NT98_3123 ENOG4107Z3H Transcriptional regulator, TetR family NT98_3125 ENOG4105CJ1 ABC, transporter NT98_3127 ENOG4107RGJ metallophosphoesterase NT98_3129 ENOG4107RF6 penicillin-binding protein NT98_313 ENOG4105D4A Cell wall formation (By similarity) NT98_3130 ENOG4107RF6 penicillin-binding protein NT98_3133 ENOG4107RVG penicillin-binding protein NT98_3134 ENOG4107RVG penicillin-binding protein NT98_3136 ENOG4108ZJ4 polysaccharide deacetylase NT98_3137 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) NT98_3138 ENOG4105CVK Glutamate decarboxylase NT98_3139 ENOG4105F6S Spore photoproduct lyase NT98_314 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) NT98_3143 ENOG4105C44 Serine transporter NT98_3144 ENOG4105EJQ L-serine dehydratase NT98_3149 ENOG4105EQK -acetyltransferase NT98_3152 ENOG4105CIN aminoacyl-histidine dipeptidase NT98_3156 ENOG4105K56 Transcriptional regulator NT98_3157 ENOG4107RA9 decarboxylase NT98_3158 ENOG4107RA9 decarboxylase NT98_3159 ENOG4108I0C methyltransferase NT98_3161 ENOG41088CC tellurite resistance protein tehB NT98_3162 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) NT98_3165 ENOG4108RZE Tetr family transcriptional regulator NT98_3171 ENOG4105C1J atp-dependent rna helicase NT98_3174 ENOG4105D7V transposase NT98_3175 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) NT98_318 ENOG4105KVH Transcriptional regulator NT98_3180 ENOG4108INS Transcriptional regulator NT98_3184 ENOG4105RD7 BadF BadG BcrA BcrD NT98_3189 ENOG4105F32 YngK protein NT98_319 ENOG4105F27 Major Facilitator NT98_3194 ENOG4108KPJ rna polymerase sigma factor NT98_3196 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) NT98_320 ENOG4105CV8 reductase NT98_3201 ENOG4108JCI Transcriptional regulator NT98_3205 ENOG4105BZ1 (ABC) transporter NT98_3206 ENOG4105BZ1 (ABC) transporter NT98_3210 ENOG4108RPX mosc domain containing protein NT98_3211 ENOG4105DND Transcriptional regulator NT98_3214 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) NT98_3215 ENOG4107V2S Transcriptional regulator NT98_3217 ENOG410667J hydrolase NT98_3221 ENOG4105VEQ Cold shock protein NT98_3223 ENOG41068WN NT98_3225 ENOG4105C1Q protoporphyrinogen oxidase NT98_3226 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) NT98_323 ENOG4108RYK Nad-dependent epimerase dehydratase NT98_3231 ENOG4105WCN acetyltransferase NT98_3235 ENOG4105EYF MMPL domain protein NT98_3238 ENOG4107MII Sugar-specific transcriptional regulator TrmB NT98_3241 ENOG41081I9 integral membrane protein NT98_3246 ENOG4108D32 Methyltransferase NT98_3254 ENOG4105C19 ABC transporter NT98_3256 ENOG4105C22 threonyL-tRNA synthetase NT98_3257 ENOG4105FE9 pseudouridine synthase NT98_326 ENOG4105D9N nucleoside NT98_3261 ENOG4105BZG amino acid carrier protein NT98_3265 ENOG4105K70 DNA-binding protein NT98_3268 ENOG4105C0R drug resistance transporter emrb qaca subfamily NT98_327 ENOG4105D9N nucleoside NT98_3270 ENOG4105CEY Amp-dependent synthetase and ligase NT98_3271 ENOG4105WQI isochorismatase NT98_3272 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase NT98_3273 ENOG4105E4F Isochorismate synthase NT98_3274 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase NT98_3275 ENOG4105FCD Major Facilitator NT98_3280 ENOG4107RFY SbcCD D subunit NT98_3283 ENOG4105E39 Enoyl-CoA hydratase NT98_3284 ENOG4105N14 lysine exporter protein LysE YggA NT98_3286 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase NT98_3287 ENOG4105C1G acyl-Coa dehydrogenase NT98_3288 ENOG4105CR4 methylisocitrate lyase NT98_3289 ENOG4105DXD 2-methylcitrate dehydratase NT98_3291 ENOG4105W8X HesB YadR YfhF-family protein NT98_3292 ENOG4105CZM Major Facilitator NT98_3294 ENOG4105BZ4 penicillin-binding protein NT98_3298 ENOG4105CHR reductase NT98_3304 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) NT98_331 ENOG4108URH decarboxylase NT98_3311 ENOG4108AEY RNA polymerase sigma factor NT98_3321 ENOG4105SZ6 Thioredoxin NT98_3322 ENOG410841Q phosphoesterase PA-phosphatase related protein NT98_3324 ENOG4108N23 SpoOM-related protein NT98_3332 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein NT98_3333 ENOG4108JUB Transcriptional regulator NT98_3334 ENOG4108TSC N-acetyltransferase NT98_3335 ENOG4107S4Y M20 DapE family protein YgeY NT98_3338 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) NT98_334 ENOG4108RMU ferritin dps family protein NT98_3343 ENOG4105C37 (CBS) domain NT98_3350 ENOG4105E90 ABC transporter NT98_3351 ENOG4108IJ8 ABC transporter NT98_3359 ENOG4105C6Z Gluconate NT98_336 ENOG4105NCW Trka-c domain protein NT98_3360 ENOG4105CMG Carbohydrate kinase NT98_3367 ENOG4106KNT transcriptional regulator NT98_3368 ENOG4105WH1 Two component transcriptional regulator luxr family NT98_3369 ENOG4105BZU Histidine kinase NT98_337 ENOG4107S91 Sodium hydrogen exchanger NT98_3370 ENOG4105D8X mechanosensitive ion channel NT98_3374 ENOG4105F0I Aminotransferase NT98_3375 ENOG4108MES Periplasmic binding protein NT98_3379 ENOG4105CAQ asparagine synthetase NT98_338 ENOG4107T5V SNARE associated Golgi NT98_3380 ENOG4107Y70 Heat shock protein NT98_3381 ENOG4108KF3 Electron transport protein SCO1 SenC NT98_3382 ENOG4105E8R UPF0173 metal-dependent hydrolase NT98_3383 ENOG4108RCR degv family NT98_3385 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) NT98_3387 ENOG4108UT2 hemolysin iii NT98_3388 ENOG4105E9Q Acyl-transferase NT98_3390 ENOG4107RVG penicillin-binding protein NT98_3393 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) NT98_3396 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 NT98_3401 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase NT98_3402 ENOG4105KD7 acetyltransferase NT98_3405 ENOG4105C0A alcohol dehydrogenase NT98_3406 ENOG4105CY2 Citrate transporter NT98_3407 ENOG4107XGZ Hydrolase NT98_3408 ENOG4107XGZ Hydrolase NT98_3412 ENOG4105C8J )-transporter NT98_3414 ENOG4105BZW Glycerate kinase NT98_3415 ENOG4105C5S asparaginyl-tRNA synthetase NT98_342 ENOG4105D4Y metalloprotease NT98_3422 ENOG4105C75 arginyL-tRNA synthetase NT98_3423 ENOG4107YX5 Pfam:DUF548 NT98_3428 ENOG4108UUM single-stranded DNA-binding protein NT98_343 ENOG4105VG1 fes assembly suf system protein NT98_3431 ENOG4105C5H ABC transporter NT98_3434 ENOG4105MCT stage V sporulation protein S NT98_344 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer NT98_3440 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) NT98_3441 ENOG4108IFG nitrite reductase, (NAD(P)H) NT98_3442 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit NT98_3443 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) NT98_3444 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein NT98_3445 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein NT98_345 ENOG4105C8Q Methyl-accepting chemotaxis NT98_3451 ENOG4108ZAF Molybdopterin NT98_3452 ENOG4105CVM Molybdenum cofactor synthesis domain protein NT98_3453 ENOG4105D06 uba thif-type nad fad binding protein NT98_3454 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) NT98_3455 ENOG4107V6Q Cyclic nucleotide-binding domain NT98_3457 ENOG4105CZV ABC transporter NT98_3461 ENOG4105R3A Nitrate reductase NT98_3462 ENOG4108IUE nitrate reductase beta subunit NT98_3464 ENOG4105C7R Atpase associated with various cellular activities aaa_3 NT98_3467 ENOG4108V06 Glutathione peroxidase NT98_3471 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) NT98_3474 ENOG4105EMN RNA polymerase sigma factor NT98_3475 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein NT98_3477 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily NT98_3481 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) NT98_3486 ENOG4105KBJ sporulation protein ytfj NT98_349 ENOG4105BZU Histidine kinase NT98_3493 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) NT98_3499 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family NT98_35 ENOG4108VKI Cell wall hydrolase NT98_350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NT98_3500 ENOG4108JYZ YitT family NT98_3501 ENOG41087PP glycosyltransferase MGT family NT98_3505 ENOG4107RBS Methyltransferase NT98_3506 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) NT98_3508 ENOG4108X4Q Hydrolase NT98_351 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein NT98_3516 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) NT98_3518 ENOG4108VXD carboxy-peptidase NT98_3520 ENOG4108ZRV stage ii sporulation protein p NT98_3523 ENOG4108Z7R Chaperone CsaA NT98_3527 ENOG4105C37 (CBS) domain NT98_3528 ENOG4105SXS Protein of unknown function (DUF456) NT98_353 ENOG4107ZTW SNARE associated Golgi NT98_3532 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) NT98_3533 ENOG4108S4H thioesterase Superfamily protein NT98_3535 ENOG4108PJD permease NT98_3538 ENOG4107T5V SNARE associated Golgi NT98_3542 ENOG4105CVJ phosphoglycerate mutase NT98_3547 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) NT98_3549 ENOG4105K4T epimerase NT98_3551 ENOG4105DSE periplasmic solute binding protein NT98_3553 ENOG4105CKI cobalamin synthesis protein NT98_3554 ENOG4107QM2 Aldo Keto reductase NT98_3555 ENOG4105VMI -acetyltransferase NT98_3558 ENOG4105DEN Luciferase family NT98_3561 ENOG4108WPJ Ferritin-like domain NT98_3562 ENOG4108K88 Membrane NT98_3570 ENOG4107XZQ multidrug resistance protein NT98_3571 ENOG4107SET aldo keto reductase NT98_3572 ENOG4105YVS arsR family transcriptional regulator NT98_3573 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase NT98_3575 ENOG4105KRN Transcriptional regulator, abrb family NT98_3585 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family NT98_3586 ENOG4108ZUB Lysine exporter protein (Lyse ygga) NT98_3588 ENOG4105YWU small acid-soluble spore protein NT98_3589 ENOG4108WBH protein TIM barrel NT98_3592 ENOG4105CEY Amp-dependent synthetase and ligase NT98_3593 ENOG4105DUU IucA IucC family protein NT98_3595 ENOG4105VRR gCN5-related N-acetyltransferase NT98_3596 ENOG4105KT7 mgtC SapB transporter NT98_3598 ENOG4107VMI polysaccharide deacetylase NT98_3599 ENOG4105BZU Histidine kinase NT98_3600 ENOG4105DPZ Two component transcriptional regulator (Winged helix family NT98_3602 ENOG4108KGH TRANSCRIPTIONal NT98_3607 ENOG4105D6E homoserine dehydrogenase NT98_361 ENOG4107AYK membrAne NT98_3611 ENOG4108ZJ4 polysaccharide deacetylase NT98_3612 ENOG41075D4 Aminoglycoside 6-adenylyltransferase NT98_3619 ENOG4105DPZ Two component transcriptional regulator (Winged helix family NT98_3621 ENOG4105BZU Histidine kinase NT98_3622 ENOG4105EFI regulatoR NT98_3623 ENOG4105BZ1 (ABC) transporter NT98_363 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins NT98_3632 ENOG4108UT6 Transferase hexapeptide repeat containing protein NT98_3634 ENOG4105K64 Glycosyl transferase, family 2 NT98_3636 ENOG4108JJ8 (ABC) transporter NT98_3637 ENOG4108JJ9 ABC, transporter NT98_3638 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii NT98_3639 ENOG4105C4M (Ubiquinol oxidase) subunit I NT98_3643 ENOG41090U3 tautomerase NT98_3645 ENOG4105SKE transcriptional Regulator LysR family NT98_3647 ENOG4105C32 Amino acid ABC transporter (Permease) NT98_3648 ENOG4108IV0 ABC, transporter NT98_3649 ENOG4105C0Z ABC transporter NT98_3652 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) NT98_3653 ENOG4108Z7G MaoC domain protein dehydratase NT98_3656 ENOG4105CKI cobalamin synthesis protein NT98_3658 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) NT98_3659 ENOG4106F5Q Membrane NT98_366 ENOG4107R7I amino acid NT98_3663 ENOG4108TVJ Nitroreductase NT98_3664 ENOG4107ZXU DSBA oxidoreductase NT98_3665 ENOG4108Z40 Transcriptional regulator NT98_3666 ENOG4105GZI Transcriptional regulator NT98_3667 ENOG4107RT3 EamA-like transporter family NT98_3668 ENOG4105KTB nuclear export factor GLE1 NT98_3669 ENOG4108T5E Copper resistance protein NT98_367 ENOG4108SUT Major Facilitator Superfamily NT98_3675 ENOG4105D7V transposase NT98_3676 ENOG4105CAQ asparagine synthetase NT98_3677 ENOG4105DND Transcriptional regulator NT98_3686 ENOG4107EXU Short-chain dehydrogenase reductase Sdr NT98_3690 ENOG4107R16 Multicopper oxidase NT98_3691 ENOG4107RAQ aminopeptidase NT98_3699 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) NT98_3700 ENOG4105D9N nucleoside NT98_3702 ENOG4107RHR regulatoR NT98_3705 ENOG4105K8R UPF0145 protein NT98_3710 ENOG4105C0X amino acid NT98_3712 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) NT98_3715 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) NT98_3719 ENOG41068WN NT98_372 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer NT98_3724 ENOG4105CYC Transferase NT98_3725 ENOG4105DY9 regulatoR NT98_3728 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b NT98_3729 ENOG4105C6X Major Facilitator NT98_3734 ENOG4105C7B Threonine dehydratase NT98_3738 ENOG4105C7K acetolactate synthase NT98_3739 ENOG4105CM2 brancheD-chain amino acid aminotransferase NT98_3740 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) NT98_3744 ENOG4105H67 Protein of unknown function (DUF421) NT98_3745 ENOG4105X5K response regulator receiver protein NT98_3747 ENOG4105C8J )-transporter NT98_3751 ENOG4105C6T cysteine synthase NT98_3752 ENOG4105EU0 Major facilitator Superfamily NT98_3754 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) NT98_3758 ENOG4105DXI Major Facilitator superfamily NT98_3759 ENOG4105CSR polyphosphate kinase 2 NT98_376 ENOG4105DZ1 carboxypeptidase NT98_3766 ENOG4105FVX NT98_3771 ENOG41067QW Transcriptional regulator NT98_3774 ENOG4105C0D helicase NT98_3777 ENOG4105C6K Malic enzyme NT98_3778 ENOG4108IJ0 Aspartate ammonia-lyase NT98_3780 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) NT98_3786 ENOG4105CJ1 ABC, transporter NT98_379 ENOG4105CHU acetyl-coa acetyltransferase NT98_3793 ENOG4106BRA Membrane NT98_3799 ENOG4107QIV Cytochrome c biogenesis protein NT98_38 ENOG4108IJ2 phosphate acetyltransferase NT98_380 ENOG4105C1G acyl-Coa dehydrogenase NT98_3803 ENOG4105EC3 peptidase S51, dipeptidase E NT98_3804 ENOG4107QJQ Mate efflux family protein NT98_3808 ENOG4105C9Q fumarate hydratase class II NT98_381 ENOG4108W8B Beta-lactamase domain protein NT98_3810 ENOG4105C9Q fumarate hydratase class II NT98_3811 ENOG4105EMU Dehydrogenase NT98_3812 ENOG4105VUF Transcriptional regulator NT98_3813 ENOG4105DFD Na H antiporter NT98_3816 ENOG4108PJD permease NT98_3817 ENOG4105CKI cobalamin synthesis protein NT98_3818 ENOG4108UZ3 Transporter NT98_3819 ENOG4105DRR Transcriptional regulator, GntR family NT98_3821 ENOG4105PGM cation diffusion facilitator family transporter NT98_3825 ENOG4105CAQ asparagine synthetase NT98_3827 ENOG4105K56 Transcriptional regulator NT98_3829 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) NT98_3832 ENOG4105CVJ phosphoglycerate mutase NT98_3840 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component NT98_3841 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein NT98_3842 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) NT98_3843 ENOG4105DUM transcriptional regulator, lysR family NT98_3849 ENOG4108U4N (sortase) family NT98_3855 ENOG4105KAC Antibiotic biosynthesis monooxygenase NT98_3863 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) NT98_3864 ENOG4105KTQ flagellar basal-body rod protein NT98_3865 ENOG4105FZW flagellar biosynthesis regulator FlhF NT98_3866 ENOG4105D7B Flagellar biosynthesis protein flha NT98_3867 ENOG4105D00 flagellar biosynthetic protein flhB NT98_3869 ENOG4105VS8 Flagellar biosynthetic protein fliq NT98_3870 ENOG4105CN7 Flagellar biosynthetic protein FliP NT98_3872 ENOG4105DD5 Flagellar motor switch protein NT98_3873 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) NT98_3875 ENOG4105E4C Lytic transglycosylase catalytic NT98_3876 ENOG4105I03 Flagellin NT98_3877 ENOG4105I03 Flagellin NT98_3878 ENOG4105I03 Flagellin NT98_3879 ENOG4105I03 Flagellin NT98_3880 ENOG4105I03 Flagellin NT98_3882 ENOG4107R88 Chemotaxis protein (CheV) NT98_3885 ENOG4105BZE flagellar hook protein, FlgE NT98_3891 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) NT98_3892 ENOG4107U2N Flagellar M-ring protein NT98_3893 ENOG41075Z6 flagellar hook-basal body complex protein fliE NT98_3894 ENOG4108ZC9 flagellar basal-body rod protein flgc NT98_3895 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) NT98_3898 ENOG410804A Flagellar hook-associated 2 domain-containing protein NT98_39 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) NT98_3900 ENOG4105E1Q flagellar hook-associated protein NT98_3904 ENOG4105BZU Histidine kinase NT98_3907 ENOG4105DD5 Flagellar motor switch protein NT98_3908 ENOG4105CBS Chea signal transduction histidine kinase NT98_3909 ENOG4107YTP response regulator receiver protein NT98_391 ENOG41080E8 Transcriptional regulator, Spx MgsR family NT98_3910 ENOG4106VK6 Flagellar motor protein NT98_3911 ENOG4107R0U MotA TolQ exbB proton channel NT98_3913 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) NT98_3924 ENOG41080C8 DUF218 domain NT98_3925 ENOG4105H67 Protein of unknown function (DUF421) NT98_3927 ENOG4108Z5V transcriptional regulator, merr family NT98_3928 ENOG4105CN5 Metallo-Beta-Lactamase NT98_3929 ENOG4107RWR Sodium hydrogen exchanger NT98_3931 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) NT98_3944 ENOG41081VK Ribonuclease NT98_3948 ENOG4108SZE gCN5-related N-acetyltransferase NT98_3951 ENOG4105CPK Glycosyl transferase (Group 1 NT98_3963 ENOG4106032 Glutathionylspermidine synthase NT98_3966 ENOG4105KHC sulfurtransferase NT98_3968 ENOG4108W0I acetyltransferase NT98_397 ENOG4108UMI ABC transporter, permease NT98_3970 ENOG410890F Dynamin family NT98_3972 ENOG4105DHF Membrane NT98_3973 ENOG4105C2W permease NT98_3974 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) NT98_3975 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) NT98_3977 ENOG4105CTD carboxy-peptidase NT98_3978 ENOG4105DVT helicase NT98_398 ENOG4105D01 (LipO)protein NT98_3980 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) NT98_399 ENOG4105D01 (LipO)protein NT98_3991 ENOG4105BZ4 penicillin-binding protein NT98_3993 ENOG4105CSM endonuclease III NT98_3997 ENOG4105YAC NT98_3998 ENOG4105DVT helicase NT98_40 ENOG4108VCI transcription factor, rsfa family NT98_400 ENOG4105C3K feS assembly ATPase SufC NT98_4005 ENOG4105CPK Glycosyl transferase (Group 1 NT98_4006 ENOG4105FJR Lmbe family NT98_4009 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase NT98_401 ENOG4105JRK feS assembly protein SufD NT98_4010 ENOG4108JYZ YitT family NT98_4017 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) NT98_4018 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) NT98_402 ENOG4105C9B Cysteine desulfurase NT98_4021 ENOG41068YB TPR repeat-containing protein NT98_4026 ENOG4105EAH synthase NT98_4028 ENOG4105XXQ heptaprenyl diphosphate synthase component I NT98_403 ENOG4108UNV SUF system FeS assembly protein, NifU family NT98_4031 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) NT98_4037 ENOG41065D1 NT98_4038 ENOG4105S2F NT98_404 ENOG4105DIW FeS assembly protein SUFB NT98_4045 ENOG4107RB3 L-asparaginase NT98_4046 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase NT98_4051 ENOG4108S6Z Negative regulator of genetic competence NT98_4052 ENOG4107X2D transcriptional regulator, merr family NT98_4053 ENOG4107RGJ metallophosphoesterase NT98_4055 ENOG4105I7S Abortive infection protein NT98_4056 ENOG4105C9U ATP-dependent DNA helicase RecQ NT98_4059 ENOG4108SAX Membrane NT98_4061 ENOG41063SB peptidase NT98_4062 ENOG4108WBT adenosyltransferase NT98_4063 ENOG4105BZU Histidine kinase NT98_4064 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NT98_4065 ENOG4105CRE cytochrome C NT98_4066 ENOG4107TWT Cytochrome c biogenesis protein NT98_4068 ENOG4105FE9 pseudouridine synthase NT98_4070 ENOG4108JIC nucleoside recognition domain protein NT98_4071 ENOG4105DZ1 carboxypeptidase NT98_4072 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) NT98_4079 ENOG4105BZU Histidine kinase NT98_408 ENOG4107R8B 5'-nucleotidase NT98_4082 ENOG4105I3N Conserved Protein NT98_4083 ENOG4105BZU Histidine kinase NT98_4086 ENOG4105BZ4 penicillin-binding protein NT98_4087 ENOG4107GRR phosphate transport regulator NT98_4088 ENOG4105CJ3 phosphate transporter NT98_409 ENOG4105KZD Domain of unknown function (DUF1805) NT98_4097 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) NT98_410 ENOG4108YTE sporulation protein YunB NT98_4101 ENOG4105WH1 Two component transcriptional regulator luxr family NT98_4102 ENOG4105ENE Histidine kinase NT98_4106 ENOG4105DFD Na H antiporter NT98_411 ENOG4105FAA peptidase M23 NT98_4110 ENOG4105C8J )-transporter NT98_4111 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein NT98_4112 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein NT98_4113 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) NT98_4115 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) NT98_4116 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) NT98_4121 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) NT98_4123 ENOG4105E0M Sulfatase NT98_4124 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase NT98_4125 ENOG4105C5I Dehydrogenase NT98_4127 ENOG4107RVV histidinol phosphate phosphatase, hisj family NT98_4142 ENOG4108ZP8 Acetolactate synthase small subunit NT98_4143 ENOG4105C7K acetolactate synthase NT98_4144 ENOG4105CM2 brancheD-chain amino acid aminotransferase NT98_4148 ENOG4105KBJ sporulation protein ytfj NT98_4149 ENOG41063Y9 NT98_4150 ENOG4105CZN Potassium uptake protein NT98_4157 ENOG4107QMU Mate efflux family protein NT98_416 ENOG41090T1 Membrane NT98_4164 ENOG4105NQC Flavodoxin NT98_4169 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein NT98_417 ENOG4107TXC Transcriptional regulator NT98_4171 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD NT98_4172 ENOG4105EA8 2-Nitropropane dioxygenase NT98_4173 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A NT98_418 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) NT98_4181 ENOG4105CJ1 ABC, transporter NT98_4183 ENOG4105CZV ABC transporter NT98_4184 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family NT98_4185 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) NT98_4186 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) NT98_4187 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) NT98_4188 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) NT98_419 ENOG4105MMD transcriptional regulator NT98_4196 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) NT98_4197 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase NT98_4199 ENOG4105BZU Histidine kinase NT98_42 ENOG4105DQ5 transport system permease protein NT98_4201 ENOG4106DF1 NT98_4203 ENOG41090MY MarR family Transcriptional regulator NT98_4204 ENOG4105BZU Histidine kinase NT98_4206 ENOG4105PXI polysaccharide deacetylase NT98_4208 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) NT98_4211 ENOG4105E98 transcriptional regulator DeoR family NT98_4214 ENOG4108KAZ Involved in phosphonate degradation (By similarity) NT98_4215 ENOG4107RCV ABC transporter, permease NT98_4216 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) NT98_4217 ENOG4105C4Y ABC transporter NT98_422 ENOG4105CBT Fructose-1,6-bisphosphatase NT98_4223 ENOG4105CHR reductase NT98_4227 ENOG4108Z7G MaoC domain protein dehydratase NT98_4228 ENOG410681C small acid-soluble spore protein NT98_4229 ENOG4105CZN Potassium uptake protein NT98_4230 ENOG4107TS3 membrane protein, TerC NT98_4231 ENOG4108QTI )-transporter NT98_4233 ENOG4106A3R peptidase NT98_4237 ENOG4105JXH GntR family transcriptional regulator NT98_4238 ENOG4105BZU Histidine kinase NT98_4239 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NT98_4242 ENOG4105CQB FAD linked oxidase domain protein NT98_4243 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) NT98_4244 ENOG4105K4I Scp-like extracellular NT98_4246 ENOG4108YBP pseudouridine synthase NT98_4248 ENOG4105EYF MMPL domain protein NT98_425 ENOG4105D4U had-superfamily hydrolase, subfamily iia NT98_4250 ENOG4107RUE extracellular solute-binding protein family 1 NT98_4252 ENOG4105D38 putrescine abc transporter NT98_4253 ENOG4105F38 ABC transporter, permease NT98_4255 ENOG4105C26 Dehydrogenase NT98_4263 ENOG4105VFR signal peptidase NT98_4264 ENOG4105DZ1 carboxypeptidase NT98_4268 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) NT98_4269 ENOG4108NE4 NT98_427 ENOG4105DYS nad(p)h dehydrogenase (quinone) NT98_4288 ENOG4105VZ8 Transcriptional regulator NT98_429 ENOG4105DAX Pfam:DUF2983 NT98_4290 ENOG4105C7S Dehydrogenase NT98_4299 ENOG4105T65 Membrane-associated protein NT98_43 ENOG4105EHG Permease protein NT98_4306 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) NT98_4310 ENOG4105DDQ anthranilate synthase NT98_4311 ENOG4105CRQ synthase (Component I) NT98_4312 ENOG4105CK7 Sodium proline symporter NT98_4327 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase NT98_4329 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase NT98_433 ENOG4108W5N phosphatidylglycerophosphatase a NT98_4330 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) NT98_4334 ENOG4107TVC Glycosyl transferase, family 2 NT98_4338 ENOG4105K64 Glycosyl transferase, family 2 NT98_4342 ENOG4105EMS pseudouridine synthase NT98_4345 ENOG4106EFP UPF0738 protein NT98_4346 ENOG4105MIX Adenylate cyclase NT98_4347 ENOG4108Z18 K06886 hemoglobin NT98_4350 ENOG4105DPN Oligoendopeptidase f NT98_4352 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) NT98_4354 ENOG4108ZCF integral membrane protein NT98_4358 ENOG4105UQX Mate efflux family protein NT98_4359 ENOG4108JQ7 (ABC) transporter NT98_436 ENOG41083MR nifu domain-containing protein NT98_4361 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component NT98_4362 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component NT98_4365 ENOG4105C31 Tryptophanyl-tRNA synthetase NT98_4368 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) NT98_4369 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) NT98_4377 ENOG4108KP7 hydrolase NT98_4379 ENOG41073B9 NT98_4380 ENOG4107AYK membrAne NT98_4382 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) NT98_4385 ENOG4105CNA YD repeat protein NT98_4388 ENOG4105CNA YD repeat protein NT98_4389 ENOG4105QNR S1 RNA binding domain protein NT98_4390 ENOG4108VPT UPF0234 protein NT98_4392 ENOG4107A6P NT98_4394 ENOG4105BZU Histidine kinase NT98_4395 ENOG4105CH6 catalase NT98_4397 ENOG4105CAQ asparagine synthetase NT98_44 ENOG4105E0A ABC, transporter NT98_4402 ENOG4105ERH Fumarylacetoacetate hydrolase NT98_441 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA NT98_4416 ENOG4105XVF Competence transcription factor NT98_4419 ENOG4105VEQ Cold shock protein NT98_442 ENOG4105C4B ABC transporter, permease NT98_4422 ENOG4107QP3 malate synthase g NT98_4423 ENOG4105ZU5 s-layer protein NT98_4427 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 NT98_443 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) NT98_4432 ENOG4105DPZ Two component transcriptional regulator (Winged helix family NT98_4436 ENOG41086D8 Transcriptional regulator NT98_4437 ENOG4108AEY RNA polymerase sigma factor NT98_4439 ENOG4107TVP HD domain protein NT98_4440 ENOG4107RN3 metallophosphoesterase NT98_4441 ENOG4105ENX hydrolase NT98_4443 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) NT98_4445 ENOG4105CEY Amp-dependent synthetase and ligase NT98_4447 ENOG4105DF9 Lipoate-protein, ligase NT98_4448 ENOG4108RQ5 Beta-lactamase domain-containing protein NT98_4449 ENOG4106AXD NT98_4451 ENOG4108MK9 spermidine N(1)-acetyltransferase NT98_4454 ENOG4105ECB domain protein NT98_4460 ENOG4105C1Q protoporphyrinogen oxidase NT98_4461 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) NT98_4463 ENOG4105BZ4 penicillin-binding protein NT98_4464 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation NT98_4465 ENOG4105CKV Membrane NT98_4466 ENOG410905X membrane-flanked domain protein NT98_4469 ENOG4105CKV Membrane NT98_447 ENOG4108YX9 iron--sulfur cluster insertion protein erpA NT98_4470 ENOG410905X membrane-flanked domain protein NT98_4477 ENOG4105K59 histidine triad (HIT) protein NT98_4482 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) NT98_4483 ENOG4105EEM helicase NT98_4484 ENOG4105EEM helicase NT98_4488 ENOG4105EMN RNA polymerase sigma factor NT98_4490 ENOG4105C6V Glycerol-3-phosphate dehydrogenase NT98_4493 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator NT98_4496 ENOG4108MUZ hydrolase NT98_45 ENOG4108MES Periplasmic binding protein NT98_4500 ENOG4105ED2 Beta-lactamase NT98_4502 ENOG4106D4I domain protein NT98_4503 ENOG4107VRP DNA repair exonuclease NT98_451 ENOG4105EWC Purine nucleoside phosphorylase NT98_4513 ENOG4105K8R UPF0145 protein NT98_4518 ENOG4105BZU Histidine kinase NT98_4519 ENOG4105BZU Histidine kinase NT98_4520 ENOG4108MJI response regulator NT98_4522 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NT98_4524 ENOG4105WN5 stage II sporulation protein NT98_4526 ENOG4107BMA Transglycosylase associated protein NT98_4531 ENOG4108WC5 Alpha Beta Hydrolase Fold protein NT98_4540 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase NT98_4545 ENOG4105CMT Dihydroxyacetone kinase NT98_4547 ENOG4105CMT Dihydroxyacetone kinase NT98_4551 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase NT98_456 ENOG4105CEP NADH dehydrogenase NT98_4562 ENOG4105C0R drug resistance transporter emrb qaca subfamily NT98_4566 ENOG4108Z86 Glutamine amidotransferase NT98_4571 ENOG4105CDU Replicative dna helicase NT98_4574 ENOG4105CDU Replicative dna helicase NT98_459 ENOG41069ER domain protein NT98_4593 ENOG4108MRH transcriptional regulatory protein NT98_4595 ENOG4105CSH Transporter NT98_46 ENOG4105DCI Phosphohydrolase NT98_4600 ENOG4105ESF Peptidoglycan binding domain protein NT98_4605 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase NT98_4609 ENOG4105ESF Peptidoglycan binding domain protein NT98_4616 ENOG4105CDU Replicative dna helicase NT98_4627 ENOG4105DER m42 family NT98_463 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase NT98_4631 ENOG4105CGU Enoyl-CoA hydratase NT98_4633 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein NT98_4635 ENOG4106AKK s-layer domain-containing protein NT98_4644 ENOG4105CHH sulfate transporter NT98_4648 ENOG4107ZTW SNARE associated Golgi NT98_4651 ENOG4105D4P Coproporphyrinogen iii oxidase NT98_4652 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase NT98_4657 ENOG4107FQX Alpha-acetolactate decarboxylase NT98_4666 ENOG410839P NT98_4669 ENOG4105CDA abc transporter atp-binding protein NT98_467 ENOG4105KA0 thioesterase Superfamily protein NT98_4670 ENOG4105DRP amino acid AbC transporter NT98_4672 ENOG4105BZ1 (ABC) transporter NT98_4673 ENOG4105BZ1 (ABC) transporter NT98_4674 ENOG4105C26 Dehydrogenase NT98_4676 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) NT98_4677 ENOG4105D5Q Arginine ornithine antiporter NT98_4679 ENOG4107RKG DJ-1/PfpI family NT98_468 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) NT98_4682 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF NT98_4687 ENOG4105C19 ABC transporter NT98_4688 ENOG4107RBB ABC transporter, permease NT98_4689 ENOG4105C19 ABC transporter NT98_4696 ENOG4105KPY Small multidrug resistance protein NT98_4697 ENOG4105KPY Small multidrug resistance protein NT98_47 ENOG41069HH 4-oxalocrotonate tautomerase NT98_4701 ENOG4108YXU transcriptional regulator AsnC family NT98_4709 ENOG4106KNT transcriptional regulator NT98_471 ENOG4107R3E Citrate transporter NT98_4711 ENOG4107RWR Sodium hydrogen exchanger NT98_4712 ENOG4105CUB amino acid NT98_4719 ENOG4107T5V SNARE associated Golgi NT98_4726 ENOG4105WEF catalase NT98_473 ENOG4105Y38 Kinase-associated protein B NT98_4733 ENOG4105C19 ABC transporter NT98_4734 ENOG4107RBB ABC transporter, permease NT98_4735 ENOG41069ER domain protein NT98_4739 ENOG4105VZJ PTS System NT98_4740 ENOG4105VCP PTS System NT98_4741 ENOG4105EMD TRANSCRIPTIONal NT98_4746 ENOG4108KGH TRANSCRIPTIONal NT98_4748 ENOG41087NI Sulfite exporter TauE/SafE NT98_4749 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase NT98_4751 ENOG4105VFE sira family NT98_4753 ENOG4105VFE sira family NT98_4754 ENOG4105VFE sira family NT98_4755 ENOG4107TPS domain protein NT98_4756 ENOG4105VFE sira family NT98_4757 ENOG4105XTG Pfam:DUF156 NT98_4758 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase NT98_476 ENOG4105C87 Aminotransferase class I and II NT98_4760 ENOG4108TCS Glutamyl endopeptidase NT98_4762 ENOG4105ED1 spovr family NT98_4763 ENOG4107Y03 Nitroreductase NT98_4767 ENOG4108B31 Spore germination protein NT98_4771 ENOG4105K63 Thioredoxin NT98_4774 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein NT98_4776 ENOG4105C7N Xanthine uracil vitamin C permease NT98_4778 ENOG4105DQ6 Transposase NT98_478 ENOG4108MUZ hydrolase NT98_4780 ENOG4105C19 ABC transporter NT98_4785 ENOG4108INS Transcriptional regulator NT98_479 ENOG4105C5I Dehydrogenase NT98_4795 ENOG4105DWF phosphomethylpyrimidine kinase NT98_4796 ENOG4105D06 uba thif-type nad fad binding protein NT98_4799 ENOG41080HI glycine oxidase NT98_48 ENOG4108Z4T Peptidase M50 NT98_480 ENOG4108ZB6 transcriptional regulator AsnC family NT98_4800 ENOG4108VEU Thiamine monophosphate synthase NT98_4802 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component NT98_4804 ENOG4105ETU transcriptional activator (TenA NT98_4808 ENOG41080XQ Signal transduction protein with cbs domains NT98_481 ENOG4105CHM Aminotransferase NT98_483 ENOG4105WG9 Conserved Protein NT98_4837 ENOG4105E2Z phosphate ABC transporter (Permease NT98_4838 ENOG4105C8U phosphate abc transporter NT98_4839 ENOG4105CVA phosphate NT98_4840 ENOG4105CE1 Ferrous iron transport protein b NT98_4841 ENOG4105CE1 Ferrous iron transport protein b NT98_4842 ENOG4105CE1 Ferrous iron transport protein b NT98_4843 ENOG4108NHD germination protein NT98_4846 ENOG4105E1V na solute symporter NT98_4847 ENOG4106CAD Protein of unknown function (DUF3311) NT98_485 ENOG4107PBV potassium channel NT98_4851 ENOG4105E2S oxidase) subunit II NT98_4852 ENOG4105BZ9 Cytochrome C oxidase, subunit I NT98_4853 ENOG4105CCU oxidase (Subunit III) NT98_4856 ENOG4105MA6 gCN5-related N-acetyltransferase NT98_4859 ENOG4105C7N Xanthine uracil vitamin C permease NT98_4860 ENOG4105C85 amino acid NT98_4864 ENOG4105DUX Transporter NT98_4866 ENOG4107D63 NT98_4867 ENOG4105VZ8 Transcriptional regulator NT98_4868 ENOG41069ER domain protein NT98_4869 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer NT98_487 ENOG4105KT7 mgtC SapB transporter NT98_4870 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) NT98_4881 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) NT98_4882 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator NT98_4883 ENOG4105CNN ABC, transporter NT98_4884 ENOG4105C2J ABC transporter NT98_4886 ENOG4108RVA ribokinase NT98_4887 ENOG4105ETE Transcriptional regulator (LacI family NT98_4888 ENOG4105C0R drug resistance transporter emrb qaca subfamily NT98_4889 ENOG41067TZ transcriptional regulator, MarR family NT98_4890 ENOG4105CXY transporter NT98_4892 ENOG4108JQ7 (ABC) transporter NT98_4893 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component NT98_4897 ENOG41068KF Universal stress protein NT98_4898 ENOG4105CHH sulfate transporter NT98_49 ENOG4108XFG YwhD family NT98_4901 ENOG4105BZU Histidine kinase NT98_4902 ENOG4105NAE bifunctional deaminase-reductase domain protein NT98_4903 ENOG4105D29 Helix-turn-helix type 11 domain protein NT98_4908 ENOG4108IQI permease NT98_4909 ENOG4105DRP amino acid AbC transporter NT98_4910 ENOG4105EAD ABC transporter NT98_4911 ENOG4105CT1 (ABC) transporter NT98_4912 ENOG4105CDA abc transporter atp-binding protein NT98_4913 ENOG4105BZG amino acid carrier protein NT98_4914 ENOG4105CRN Aminoglycoside phosphotransferase NT98_4916 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin NT98_4917 ENOG4105WH1 Two component transcriptional regulator luxr family NT98_4918 ENOG4108XG2 Histidine kinase NT98_4919 ENOG4105E1K spore germination protein NT98_4923 ENOG4105CG3 alpha amylase, catalytic region NT98_4924 ENOG4105C5Y PTS System NT98_4925 ENOG4107414 GntR family transcriptional regulator NT98_4926 ENOG4105D5Q Arginine ornithine antiporter NT98_4927 ENOG4105BZU Histidine kinase NT98_4930 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) NT98_4931 ENOG4105GMT ATPase associated with various cellular activities aaa_5 NT98_4932 ENOG4107T89 von Willebrand factor, type A NT98_4934 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) NT98_4935 ENOG4105EXW epimerase dehydratase NT98_4937 ENOG4105DMQ Methyltransferase NT98_4938 ENOG4105E0A ABC, transporter NT98_4939 ENOG4108IHU transport system permease protein NT98_4940 ENOG4105DQ5 transport system permease protein NT98_4941 ENOG4108MES Periplasmic binding protein NT98_4942 ENOG4105DUX Transporter NT98_4945 ENOG4105DAA L-lactate NT98_4946 ENOG4108IJ0 Aspartate ammonia-lyase NT98_4947 ENOG4105C37 (CBS) domain NT98_4948 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase NT98_4949 ENOG4105D9N nucleoside NT98_495 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation NT98_4950 ENOG4108KGH TRANSCRIPTIONal NT98_4951 ENOG41073R8 VanW family NT98_4959 ENOG4105DAP Nicotinate phosphoribosyltransferase NT98_4960 ENOG4105C59 p-type ATPase NT98_4962 ENOG4105CUB amino acid NT98_4966 ENOG4108JB9 formate dehydrogenase NT98_4967 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) NT98_4968 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) NT98_4970 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NT98_4971 ENOG4105BZU Histidine kinase NT98_4973 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family NT98_4974 ENOG4108UZ3 Transporter NT98_4976 ENOG4105C6K Malic enzyme NT98_4978 ENOG4108MRH transcriptional regulatory protein NT98_4983 ENOG4105US7 Histidine kinase NT98_4984 ENOG4108STX response regulator NT98_4989 ENOG4105D4T Citrate transporter NT98_4990 ENOG4108V9W transcriptional regulatory protein NT98_4991 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism NT98_4993 ENOG4105DZ6 Band 7 protein NT98_4996 ENOG4105C94 Transporter NT98_4999 ENOG4108WCX response regulator NT98_50 ENOG4105BZ4 penicillin-binding protein NT98_5002 ENOG410695V Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP (By similarity) NT98_5017 ENOG4105CJ1 ABC, transporter NT98_5019 ENOG4105CYN Serine protein kinase NT98_5021 ENOG4105BZU Histidine kinase NT98_5022 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) NT98_5024 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) NT98_5026 ENOG4107ZQN disulfide bond NT98_5027 ENOG4108JQC penicillin-binding protein 1A NT98_5052 ENOG4105G5W regulator Fur family NT98_5053 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen NT98_5057 ENOG4108IUW ABC transporter NT98_5059 ENOG4105CBC glutamate synthase NT98_5060 ENOG4107NBY Membrane NT98_5061 ENOG4105BZ1 (ABC) transporter NT98_5065 ENOG4106BXE NT98_5066 ENOG4105CEN a g-specific adenine glycosylase NT98_5067 ENOG41067AE Membrane-bound metal-dependent hydrolase NT98_5073 ENOG4105ECP epimerase NT98_5074 ENOG4105CI2 imidazolone-5-propionate hydrolase NT98_5078 ENOG4105F1A Pyruvate formate-lyase NT98_5081 ENOG4105C3I Nad-dependent epimerase dehydratase NT98_5082 ENOG4107QQG Dehydrogenase NT98_5083 ENOG4105CKK Glycosyl transferase, family 2 NT98_5087 ENOG4108A04 Beta-lactamase NT98_5089 ENOG4105CSV Glutaminase NT98_5095 ENOG4108IQI permease NT98_5097 ENOG4108JUB Transcriptional regulator NT98_51 ENOG4108QXE glycerophosphoryl diester phosphodiesterase NT98_5107 ENOG4105UPD Calcium Proton NT98_5108 ENOG410606W general stress protein NT98_5111 ENOG4107ZTW SNARE associated Golgi NT98_5113 ENOG4105C3F Signal peptidase i NT98_5115 ENOG4108IPJ Membrane NT98_5116 ENOG4105C59 p-type ATPase NT98_5117 ENOG4107U9T Pfam:Ribonuclease_BN NT98_5119 ENOG4105KJF protein tyrosine phosphatase NT98_5123 ENOG4108TTB tellurium resistance protein NT98_5124 ENOG4107TS3 membrane protein, TerC NT98_5125 ENOG4106FN3 tellurium resistance protein NT98_5126 ENOG4106FN3 tellurium resistance protein NT98_5127 ENOG4108N0M stress protein NT98_5133 ENOG4105DEU major facilitator superfamily NT98_5137 ENOG41062JF Transcriptional regulator NT98_5144 ENOG4105C5H ABC transporter NT98_5148 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component NT98_515 ENOG4105EMN RNA polymerase sigma factor NT98_5151 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter NT98_5157 ENOG4105CI1 PTS System NT98_5159 ENOG4105DNP FAD linked oxidase domain protein NT98_5160 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer NT98_5162 ENOG4105EAB amino acid AbC transporter NT98_5163 ENOG4105E5Q amino acid AbC transporter NT98_5166 ENOG4105D2S major facilitator superfamily NT98_5167 ENOG410756H nucleotidyltransferase NT98_517 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) NT98_5175 ENOG4106UIA NT98_5176 ENOG4106UIA NT98_518 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin NT98_5180 ENOG4108V5C ABC transporter NT98_5181 ENOG4105DQ5 transport system permease protein NT98_5182 ENOG4105EHG Permease protein NT98_5183 ENOG4107W7X Aldolase NT98_5184 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) NT98_5185 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) NT98_5186 ENOG4105D3R alkyl hydroperoxide reductase NT98_5191 ENOG4105DFD Na H antiporter NT98_5192 ENOG4105DTQ mandelate racemase muconate lactonizing NT98_5195 ENOG4108W15 Protein of unknown function (DUF1456) NT98_5196 ENOG4105BZU Histidine kinase NT98_5198 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) NT98_5199 ENOG4105D9N nucleoside NT98_52 ENOG4107SWG transcriptional regulator MERR family NT98_5203 ENOG4105KPY Small multidrug resistance protein NT98_5204 ENOG4105C26 Dehydrogenase NT98_5206 ENOG4108JPW Aminotransferase NT98_5208 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) NT98_5209 ENOG4105CBD Diacylglycerol kinase NT98_5213 ENOG4107I77 yiaA/B two helix domain NT98_5214 ENOG410834F Transcriptional regulator NT98_5218 ENOG4105D01 (LipO)protein NT98_5219 ENOG4108UMI ABC transporter, permease NT98_5221 ENOG4108W2Y isochorismatase NT98_5227 ENOG4105C4R Atp-dependent dna helicase NT98_5232 ENOG4105C12 Phosphoribosylglycinamide synthetase NT98_5234 ENOG4108V3E phosphoribosylglycinamide formyltransferase NT98_5239 ENOG4105VR9 phosphoribosylformylglycinamidine synthase NT98_5241 ENOG4105C83 adenylosuccinate lyase NT98_5242 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit NT98_5243 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) NT98_5248 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family NT98_5253 ENOG4108SHN Glycosyl transferase, family 2 NT98_5257 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) NT98_5265 ENOG4107ZXU DSBA oxidoreductase NT98_5271 ENOG4105BZU Histidine kinase NT98_5273 ENOG4105C7N Xanthine uracil vitamin C permease NT98_5275 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) NT98_5277 ENOG4108TYN CAAX amino terminal protease family protein NT98_5280 ENOG4105C5H ABC transporter NT98_5282 ENOG410801F ribosomal-protein-alanine acetyltransferase NT98_5283 ENOG41072GX Peptidase M22 Glycoprotease NT98_5284 ENOG4105K8N protein family UPF0079, ATPase NT98_529 ENOG4105VEQ Cold shock protein NT98_53 ENOG4105DXB Major Facilitator superfamily NT98_5304 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) NT98_5306 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) NT98_5307 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein NT98_531 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase NT98_5312 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) NT98_5313 ENOG4105CPF Cell wall formation (By similarity) NT98_5314 ENOG4108SC4 )-transporter NT98_5315 ENOG4105CUB amino acid NT98_5317 ENOG4105ERH Fumarylacetoacetate hydrolase NT98_5318 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase NT98_532 ENOG4105E4F Isochorismate synthase NT98_5324 ENOG410667J hydrolase NT98_5325 ENOG4108JQ7 (ABC) transporter NT98_5326 ENOG4105C3U ABC transporter NT98_5327 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component NT98_5329 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein NT98_5330 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein NT98_5332 ENOG4108KYE ABC-2 type transporter NT98_5333 ENOG41090VJ ABC-2 type transporter NT98_5334 ENOG4105CJ1 ABC, transporter NT98_5335 ENOG4105WH1 Two component transcriptional regulator luxr family NT98_5336 ENOG4105BZU Histidine kinase NT98_5337 ENOG4105C5H ABC transporter NT98_534 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) NT98_5340 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) NT98_5343 ENOG4108RE7 deoxyribonuclease NT98_5346 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) NT98_535 ENOG4108IPT Naphthoate synthase NT98_5350 ENOG4105F6E Acyl-transferase NT98_5355 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family NT98_5356 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein NT98_5357 ENOG4105E0C molybdate abc transporter NT98_5359 ENOG4106Z1T Nicotinamide Mononucleotide Transporter NT98_5360 ENOG4105II7 pyrroline-5-carboxylate reductase NT98_5362 ENOG4108J59 Extracellular solute-binding protein, family 5 NT98_5363 ENOG4108J59 Extracellular solute-binding protein, family 5 NT98_5366 ENOG4108JQ7 (ABC) transporter NT98_5367 ENOG4105C3U ABC transporter NT98_5368 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component NT98_5369 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component NT98_537 ENOG4105DTQ mandelate racemase muconate lactonizing NT98_5373 ENOG4105C2C drug resistance transporter, Bcr CflA NT98_5377 ENOG4105IQ5 FAD linked oxidase domain protein NT98_5379 ENOG4105EE1 crotonyl-CoA reductase NT98_5380 ENOG4108PSK reductase NT98_5387 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) NT98_5389 ENOG4107U5W ybbr family NT98_5390 ENOG4105C8B TIGR00159 family NT98_5408 ENOG4108NMV polysaccharide deacetylase NT98_5411 ENOG4105D1F ATP-binding protein NT98_5417 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) NT98_5424 ENOG41067V7 50S ribosomal protein L36 NT98_5426 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) NT98_5428 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) NT98_543 ENOG41069H0 dihydroorotase EC 3.5.2.3 NT98_5433 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) NT98_5454 ENOG4105XPM ribosomal protein NT98_5457 ENOG4107Y49 methyltransferase NT98_5462 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) NT98_5464 ENOG4105QIV RNA polymerase NT98_5465 ENOG4105M0M Tetracycline resistance protein NT98_5466 ENOG4105C2N RNA methyltransferase TrmH family group 3 NT98_5469 ENOG4105D7W serine acetyltransferase NT98_547 ENOG4105FDP GntR family transcriptional regulator NT98_5473 ENOG4105CTP PilT protein domain protein NT98_5475 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) NT98_5478 ENOG4108Z0C Uvrb UvrC protein NT98_548 ENOG4105C6Z Gluconate NT98_5497 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) NT98_5499 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase NT98_55 ENOG4105CYW agmatinase NT98_5500 ENOG4105KRF dihydroneopterin aldolase NT98_5501 ENOG4105EEI dihydropteroate synthase NT98_5502 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 NT98_5503 ENOG4105DDQ anthranilate synthase NT98_5504 ENOG4105CRQ synthase (Component I) NT98_5505 ENOG4105C6T cysteine synthase NT98_5508 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) NT98_5509 ENOG4108UGV hypoxanthine phosphoribosyltransferase NT98_5514 ENOG41060GV RNA binding s1 domain protein NT98_5517 ENOG4105VYY sporulation protein yabp NT98_5518 ENOG41082I2 s4 domain protein NT98_5519 ENOG4108IY2 MazG family NT98_5521 ENOG4108M14 stage v sporulation protein t NT98_5522 ENOG4108JA2 transcriptioN-repair coupling factor NT98_5525 ENOG4105C5T Phosphoribosyl pyrophosphate synthase NT98_5528 ENOG4105KME endoribonuclease L-psp NT98_5529 ENOG4105DFT pur operon repressor NT98_5532 ENOG4105W42 Veg protein NT98_5533 ENOG4105XFA sporulation peptidase YabG NT98_5535 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) NT98_5536 ENOG4105F8V Hydrolase, tatD family NT98_5537 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) NT98_5538 ENOG4105KRN Transcriptional regulator, abrb family NT98_5539 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) NT98_5541 ENOG41060K3 Methyltransferase NT98_5543 ENOG4105MA4 psp1 domain protein NT98_5544 ENOG4105FA2 dna polymerase iii NT98_5546 ENOG4105CXN decarboxylase NT98_5554 ENOG41067KS pro-sigma K processing NT98_5558 ENOG4105C6E dna polymerase iii NT98_5559 ENOG4108Z6B deaminase NT98_5560 ENOG4105GTG Isochorismatase NT98_5562 ENOG4105ZMH deoxynucleoside kinase NT98_5569 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) NT98_5579 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) NT98_558 ENOG41082BM Transcriptional regulator, arsr family NT98_5582 ENOG410848D S4 domain protein YaaA NT98_5583 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) NT98_5587 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins NT98_5593 ENOG4107QJE Chromosome Partitioning Protein NT98_5594 ENOG4105FA0 parb-like partition protein NT98_5595 ENOG4108ZDA Sporulation protein YyaC NT98_5596 ENOG4105D8X mechanosensitive ion channel NT98_5597 ENOG4105VDK protein, conserved in bacteria NT98_5598 ENOG4105C3G gtp-binding protein NT98_560 ENOG41086D8 Transcriptional regulator NT98_5600 ENOG4108UUM single-stranded DNA-binding protein NT98_5602 ENOG4108XMW Membrane NT98_5603 ENOG4105BZR domain protein NT98_5605 ENOG4105CDU Replicative dna helicase NT98_561 ENOG4105C19 ABC transporter NT98_5611 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NT98_5612 ENOG4105BZU Histidine kinase NT98_5615 ENOG4105Q2H domain protein NT98_5616 ENOG4105C0H protease NT98_5621 ENOG4105DPN Oligoendopeptidase f NT98_5624 ENOG4105C1J atp-dependent rna helicase NT98_5626 ENOG4108UT2 hemolysin iii NT98_5627 ENOG4105CMR udp-glucose 4-epimerase NT98_5629 ENOG4105IW1 AmiS UreI transporter NT98_5631 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) NT98_5634 ENOG4107RGD Major Facilitator superfamily NT98_5635 ENOG4108HRK Histidine kinase NT98_5636 ENOG4105DY9 regulatoR NT98_5639 ENOG4106F5Q Membrane NT98_5640 ENOG4105E0X reductase NT98_5642 ENOG41067SE Tetr family transcriptional regulator NT98_5643 ENOG4105CKK Glycosyl transferase, family 2 NT98_5647 ENOG4105C5H ABC transporter NT98_5648 ENOG4105JEU Glycosyl transferase, family 2 NT98_5650 ENOG4108S4H thioesterase Superfamily protein NT98_566 ENOG4107ZTW SNARE associated Golgi NT98_5661 ENOG4105EKQ RNA-directed DNA polymerase NT98_5666 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NT98_5668 ENOG4105D7V transposase NT98_5683 ENOG4105CMG Carbohydrate kinase NT98_5685 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) NT98_5695 ENOG4105K4H Nlp p60 protein NT98_5698 ENOG41067SE Tetr family transcriptional regulator NT98_5702 ENOG4105D7V transposase NT98_5708 ENOG4105C5X domain protein NT98_571 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) NT98_572 ENOG4108UGV hypoxanthine phosphoribosyltransferase NT98_5720 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) NT98_5734 ENOG4105K5B UPF0225 protein NT98_5737 ENOG4105C6E dna polymerase iii NT98_5738 ENOG4105D7V transposase NT98_5739 ENOG4105C6E dna polymerase iii NT98_5749 ENOG4105DQ6 Transposase NT98_5757 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family NT98_5762 ENOG4108KGH TRANSCRIPTIONal NT98_5764 ENOG4105HTX biosynthesis protein NT98_5765 ENOG4107YJ4 chain length determinant protein NT98_5767 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase NT98_5768 ENOG4105D3Q Sugar transferase NT98_5769 ENOG4105D2T synthase NT98_577 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NT98_5770 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase NT98_5771 ENOG4105F0R Cytidylyltransferase NT98_5779 ENOG4105F32 YngK protein NT98_578 ENOG4105BZU Histidine kinase NT98_5783 ENOG4105DQ6 Transposase NT98_5787 ENOG4105C6T cysteine synthase NT98_5791 ENOG4105C0H protease NT98_5800 ENOG4105DQ6 Transposase NT98_5818 ENOG4105C0H protease NT98_5822 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NT98_5825 ENOG4107RBB ABC transporter, permease NT98_5826 ENOG4105C19 ABC transporter NT98_5828 ENOG4105CXY transporter NT98_584 ENOG41087YS Phage shock protein A NT98_5847 ENOG4105YWU small acid-soluble spore protein NT98_5858 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) NT98_5893 ENOG4106CVF DNA replication protein NT98_59 ENOG410684U Domain of unknown function (DUF1934) NT98_5903 ENOG4105D7V transposase NT98_5911 ENOG4108IMY Transcriptional regulator NT98_5918 ENOG4107QJE Chromosome Partitioning Protein NT98_594 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii NT98_5948 ENOG4108TFU terminase (Small subunit) NT98_595 ENOG4105C4M (Ubiquinol oxidase) subunit I NT98_597 ENOG4108V2W Carbonate dehydratase NT98_609 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase NT98_61 ENOG4105EMN RNA polymerase sigma factor NT98_612 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component NT98_614 ENOG4105D2X ABC transporter substrate-binding protein NT98_617 ENOG4107T7U Sulfatase NT98_618 ENOG4107S9D Alpha beta hydrolase NT98_619 ENOG4105BZU Histidine kinase NT98_620 ENOG4105BZU Histidine kinase NT98_635 ENOG4108RIR Molybdenum cofactor biosynthesis protein NT98_637 ENOG4105BZF Glycosyl transferase (Group 1 NT98_638 ENOG4105YVM Phosphoesterase, PA-phosphatase related NT98_639 ENOG4108Z0R Transferase NT98_640 ENOG4105E8V Alpha Beta Hydrolase Fold protein NT98_645 ENOG4107A6P NT98_648 ENOG4105DA5 (ABC) transporter NT98_650 ENOG4105N5T Radical SAM Protein NT98_654 ENOG4105C19 ABC transporter NT98_657 ENOG4105NCW Trka-c domain protein NT98_658 ENOG4107S91 Sodium hydrogen exchanger NT98_659 ENOG410605W Major Facilitator NT98_66 ENOG4105IIU Aminopeptidase NT98_665 ENOG4108B31 Spore germination protein NT98_667 ENOG4105DWV Homoserine O-trans-acetylase NT98_669 ENOG41085GJ domain protein NT98_67 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) NT98_673 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) NT98_674 ENOG4105D06 uba thif-type nad fad binding protein NT98_676 ENOG4105CVM Molybdenum cofactor synthesis domain protein NT98_677 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein NT98_678 ENOG4108ZAF Molybdopterin NT98_68 ENOG4108M15 ABC transporter NT98_682 ENOG4107EXU Short-chain dehydrogenase reductase Sdr NT98_683 ENOG4108VJ1 Transcriptional regulator (CarD family NT98_69 ENOG4105KCT ABC transporter NT98_690 ENOG4105CBX hi0933 family NT98_693 ENOG4105YW5 deoR family transcriptional regulator NT98_694 ENOG4107QSE Dipeptidase NT98_696 ENOG4108IUM Glycogen debranching enzyme NT98_697 ENOG4108V15 phosphotransferase enzyme family NT98_7 ENOG41079KZ Major Facilitator Superfamily NT98_70 ENOG4105BZU Histidine kinase NT98_700 ENOG4105C8F Beta-lactamase domain protein NT98_706 ENOG4108VDD TRNA binding domain protein NT98_713 ENOG4105K7K Transcriptional regulator NT98_715 ENOG4108IPJ Membrane NT98_720 ENOG4105C88 aminopeptidase NT98_724 ENOG4105ETE Transcriptional regulator (LacI family NT98_729 ENOG4105EP9 oxidoreductase NT98_730 ENOG4105DY9 regulatoR NT98_736 ENOG4106HB6 Alpha beta hydrolase NT98_737 ENOG4105DGU Histone deacetylase NT98_738 ENOG4105W87 Cbs domain NT98_739 ENOG4105F1V Acetoin utilization protein NT98_741 ENOG4108UW5 maltose o-acetyltransferase NT98_75 ENOG4105BZU Histidine kinase NT98_750 ENOG4105C28 cystathionine NT98_752 ENOG4105U5Y Transcriptional regulator NT98_754 ENOG4105C5Q Transcriptional regulator NT98_759 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) NT98_761 ENOG4105EFZ amidohydrolase NT98_764 ENOG4105KBJ sporulation protein ytfj NT98_765 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) NT98_771 ENOG4108JYZ YitT family NT98_779 ENOG4107YZX Universal stress protein NT98_78 ENOG4105DF6 Fe-S oxidoreductase NT98_783 ENOG4105VZ8 Transcriptional regulator NT98_785 ENOG41082W1 Cupin 2, conserved barrel domain protein NT98_786 ENOG4105Z7P Acetyltransferase (GNAT) family NT98_794 ENOG4105DC7 peptidase M24 NT98_8 ENOG4105DY9 regulatoR NT98_80 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase NT98_802 ENOG4105SFS phosphoesterase RecJ domain protein NT98_804 ENOG4105VV2 NT98_805 ENOG4105C0B DNA polymerase III (alpha subunit) NT98_806 ENOG4105C6K Malic enzyme NT98_807 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family NT98_81 ENOG4105C1G acyl-Coa dehydrogenase NT98_812 ENOG4105FS0 cytoplasmic membrane protein NT98_813 ENOG4108REF Sporulation integral membrane protein ytvi NT98_815 ENOG4105BZN citrate synthase NT98_816 ENOG4108HMX isocitrate dehydrogenase (NADP) NT98_82 ENOG4105C1G acyl-Coa dehydrogenase NT98_821 ENOG4105DPZ Two component transcriptional regulator (Winged helix family NT98_822 ENOG4105BZU Histidine kinase NT98_823 ENOG4105C2M dna polymerase I NT98_826 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) NT98_827 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase NT98_829 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) NT98_833 ENOG4108TDW sporulation protein YtxC NT98_834 ENOG4105C22 threonyL-tRNA synthetase NT98_835 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) NT98_839 ENOG4105CN9 Peptidase m42 family protein NT98_840 ENOG4108JGH Tetr family transcriptional regulator NT98_841 ENOG4105CW7 secretion protein, HlyD family NT98_842 ENOG4105C0R drug resistance transporter emrb qaca subfamily NT98_846 ENOG4108RWN rrna methyltransferase NT98_848 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) NT98_849 ENOG4105C5S asparaginyl-tRNA synthetase NT98_852 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) NT98_855 ENOG4105DCG PHP domain protein NT98_858 ENOG4105FE9 pseudouridine synthase NT98_860 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) NT98_862 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) NT98_865 ENOG4105E0A ABC, transporter NT98_866 ENOG4105KFN sortase, SrtB family NT98_868 ENOG4105DR4 Methyltransferase NT98_871 ENOG4105DPZ Two component transcriptional regulator (Winged helix family NT98_881 ENOG4105CEY Amp-dependent synthetase and ligase NT98_882 ENOG4107Z3H Transcriptional regulator, TetR family NT98_883 ENOG41060WC Enoyl-CoA hydratase NT98_884 ENOG4105BZJ Electron transfer flavoprotein NT98_885 ENOG4105C10 Electron transfer flavoprotein NT98_886 ENOG4105K63 Thioredoxin NT98_889 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit NT98_89 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) NT98_891 ENOG4105E33 succinate dehydrogenase NT98_893 ENOG4108VXD carboxy-peptidase NT98_895 ENOG4105E14 MotA TolQ exbB proton channel NT98_896 ENOG4105ER2 Ompa motb domain protein NT98_897 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family NT98_898 ENOG4108IUX (ABC) transporter NT98_899 ENOG4105RHA ABC transporter, permease NT98_9 ENOG4105D22 carbon starvation protein NT98_90 ENOG4105CBT Fructose-1,6-bisphosphatase NT98_900 ENOG4108Z40 Transcriptional regulator NT98_901 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) NT98_903 ENOG4108JCI Transcriptional regulator NT98_904 ENOG41067S9 phage shock protein C, PspC NT98_905 ENOG4105DZC cytosine deaminase NT98_907 ENOG4105PFC Transcriptional regulator NT98_91 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) NT98_94 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) NT98_941 ENOG4105KBX Transcriptional regulator, TetR family NT98_943 ENOG4105C0R drug resistance transporter emrb qaca subfamily NT98_945 ENOG4108XJQ germination protein NT98_948 ENOG4105M59 Phosphodiesterase, mj0936 family NT98_95 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) NT98_952 ENOG4108QCI YvbH-like oligomerisation region NT98_958 ENOG4108IUQ atp-dependent protease NT98_96 ENOG4108ZXQ stage ii sporulation protein r NT98_962 ENOG4105K56 Transcriptional regulator NT98_967 ENOG4105D52 delta-aminolevulinic acid dehydratase NT98_969 ENOG41068KH stage VI sporulation protein D NT98_972 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase NT98_976 ENOG4105DFF Rod shape-determining protein mreb NT98_977 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) NT98_98 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) NT98_980 ENOG4107QMS site-determining protein NT98_983 ENOG4105C03 ribonuclease NT98_985 ENOG4105X36 (ribosomal) protein NT98_988 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control NT98_990 ENOG4105EWM Histidine kinase NT98_991 ENOG4105C19 ABC transporter NT98_994 ENOG4105CQC Prephenate dehydratase NT98_995 ENOG4108RPX mosc domain containing protein NT98_998 ENOG4108IYU L-aspartate oxidase NT98_999 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase