locus-tag class description FORC085_002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC085_003 ENOG410848D S4 domain protein YaaA FORC085_006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC085_008 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FORC085_014 ENOG4105ZMH deoxynucleoside kinase FORC085_016 ENOG4105GTG Isochorismatase FORC085_017 ENOG4108Z6B deaminase FORC085_018 ENOG4105C6E dna polymerase iii FORC085_023 ENOG41067KS pro-sigma K processing FORC085_025 ENOG4105CXN decarboxylase FORC085_027 ENOG4105FA2 dna polymerase iii FORC085_028 ENOG4105MA4 psp1 domain protein FORC085_030 ENOG41060K3 Methyltransferase FORC085_032 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FORC085_033 ENOG4105KRN Transcriptional regulator, abrb family FORC085_034 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FORC085_035 ENOG4105F8V Hydrolase, tatD family FORC085_036 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FORC085_038 ENOG4105XFA sporulation peptidase YabG FORC085_039 ENOG4105W42 Veg protein FORC085_042 ENOG4105DFT pur operon repressor FORC085_043 ENOG4105KME endoribonuclease L-psp FORC085_046 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FORC085_047 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FORC085_049 ENOG4108JA2 transcriptioN-repair coupling factor FORC085_050 ENOG4108M14 stage v sporulation protein t FORC085_052 ENOG4108IY2 MazG family FORC085_053 ENOG41082I2 s4 domain protein FORC085_054 ENOG4105VYY sporulation protein yabp FORC085_057 ENOG41060GV RNA binding s1 domain protein FORC085_059 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FORC085_060 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC085_061 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FORC085_064 ENOG4105C6T cysteine synthase FORC085_065 ENOG4105CRQ synthase (Component I) FORC085_066 ENOG4105DDQ anthranilate synthase FORC085_067 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FORC085_068 ENOG4105EEI dihydropteroate synthase FORC085_069 ENOG4105KRF dihydroneopterin aldolase FORC085_070 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FORC085_072 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FORC085_077 ENOG4108Z0C Uvrb UvrC protein FORC085_080 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FORC085_082 ENOG4105CTP PilT protein domain protein FORC085_083 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FORC085_086 ENOG4105D7W serine acetyltransferase FORC085_089 ENOG4105C2N RNA methyltransferase TrmH family group 3 FORC085_090 ENOG4105M0M Tetracycline resistance protein FORC085_091 ENOG4105QIV RNA polymerase FORC085_093 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FORC085_098 ENOG4107Y49 methyltransferase FORC085_1004 ENOG4107VRP DNA repair exonuclease FORC085_1005 ENOG4106D4I domain protein FORC085_1007 ENOG4105ED2 Beta-lactamase FORC085_101 ENOG4105XPM ribosomal protein FORC085_1015 ENOG4108MUZ hydrolase FORC085_1021 ENOG4105F0F Oxalate decarboxylase FORC085_1022 ENOG41067QW Transcriptional regulator FORC085_1024 ENOG4105D7V transposase FORC085_1025 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC085_1028 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FORC085_1036 ENOG4105EEM helicase FORC085_1038 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC085_1044 ENOG4105K59 histidine triad (HIT) protein FORC085_1051 ENOG410905X membrane-flanked domain protein FORC085_1052 ENOG4105CKV Membrane FORC085_1060 ENOG410905X membrane-flanked domain protein FORC085_1061 ENOG4105CKV Membrane FORC085_1062 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FORC085_1063 ENOG4105BZ4 penicillin-binding protein FORC085_1065 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC085_1066 ENOG4105C1Q protoporphyrinogen oxidase FORC085_1071 ENOG4105NA0 Transcriptional regulator FORC085_1074 ENOG4105ECB domain protein FORC085_1078 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC085_1080 ENOG4106AXD FORC085_1081 ENOG4108RQ5 Beta-lactamase domain-containing protein FORC085_1082 ENOG4105DF9 Lipoate-protein, ligase FORC085_1084 ENOG4105CEY Amp-dependent synthetase and ligase FORC085_1086 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FORC085_1087 ENOG4108I5D sulfate abc transporter FORC085_1088 ENOG4105ECW sulfate abc transporter FORC085_1089 ENOG4108IJ6 ABC transporter FORC085_1110 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) FORC085_1111 ENOG4107RN3 metallophosphoesterase FORC085_1112 ENOG4107TVP HD domain protein FORC085_1114 ENOG4108AEY RNA polymerase sigma factor FORC085_1115 ENOG41086D8 Transcriptional regulator FORC085_1118 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC085_1122 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FORC085_1123 ENOG4105C8Q Methyl-accepting chemotaxis FORC085_1124 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FORC085_1127 ENOG4107QP3 malate synthase g FORC085_1131 ENOG4105VEQ Cold shock protein FORC085_1139 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FORC085_1148 ENOG4105ERH Fumarylacetoacetate hydrolase FORC085_1150 ENOG4105C8Y Acetylornithine aminotransferase FORC085_1151 ENOG4106BKT UPF0344 protein FORC085_1153 ENOG4105CAQ asparagine synthetase FORC085_1154 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC085_1155 ENOG4105CH6 catalase FORC085_1156 ENOG4105BZU Histidine kinase FORC085_1160 ENOG4108VPT UPF0234 protein FORC085_1161 ENOG4105QNR S1 RNA binding domain protein FORC085_1162 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC085_1164 ENOG4107AYK membrAne FORC085_1165 ENOG41073B9 FORC085_1167 ENOG4108KP7 hydrolase FORC085_1169 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FORC085_1174 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FORC085_1175 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FORC085_1178 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC085_1181 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC085_1182 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC085_1184 ENOG4108JQ7 (ABC) transporter FORC085_1185 ENOG4105UQX Mate efflux family protein FORC085_1189 ENOG4108ZCF integral membrane protein FORC085_1191 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC085_1193 ENOG4105DPN Oligoendopeptidase f FORC085_1196 ENOG4108Z18 K06886 hemoglobin FORC085_1197 ENOG4105MIX Adenylate cyclase FORC085_1198 ENOG4106EFP UPF0738 protein FORC085_1200 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FORC085_1201 ENOG4105EMS pseudouridine synthase FORC085_1205 ENOG4105K64 Glycosyl transferase, family 2 FORC085_1209 ENOG4107TVC Glycosyl transferase, family 2 FORC085_1213 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FORC085_1214 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FORC085_1216 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FORC085_122 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FORC085_1226 ENOG4108ZMI UPF0477 protein FORC085_1231 ENOG4105CK7 Sodium proline symporter FORC085_1233 ENOG4105CRQ synthase (Component I) FORC085_1234 ENOG4105DDQ anthranilate synthase FORC085_1238 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FORC085_1253 ENOG4105C7S Dehydrogenase FORC085_1254 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FORC085_1256 ENOG4105VZ8 Transcriptional regulator FORC085_1267 ENOG4105DZ1 carboxypeptidase FORC085_1268 ENOG4105VFR signal peptidase FORC085_127 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC085_1275 ENOG4105C26 Dehydrogenase FORC085_1276 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC085_1277 ENOG4105F38 ABC transporter, permease FORC085_1278 ENOG4105D38 putrescine abc transporter FORC085_1279 ENOG4107RUE extracellular solute-binding protein family 1 FORC085_1281 ENOG4105EYF MMPL domain protein FORC085_1283 ENOG4108YBP pseudouridine synthase FORC085_1285 ENOG4105K4I Scp-like extracellular FORC085_1286 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FORC085_1287 ENOG4105CQB FAD linked oxidase domain protein FORC085_129 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC085_1290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC085_1291 ENOG4105BZU Histidine kinase FORC085_1292 ENOG4105JXH GntR family transcriptional regulator FORC085_1296 ENOG4106A3R peptidase FORC085_1298 ENOG4108QTI )-transporter FORC085_1300 ENOG4107TS3 membrane protein, TerC FORC085_1301 ENOG4105CZN Potassium uptake protein FORC085_1302 ENOG410681C small acid-soluble spore protein FORC085_1303 ENOG4108Z7G MaoC domain protein dehydratase FORC085_1307 ENOG4105CHR reductase FORC085_1309 ENOG4105DQ6 Transposase FORC085_131 ENOG41067V7 50S ribosomal protein L36 FORC085_1315 ENOG4105C4Y ABC transporter FORC085_1316 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC085_1317 ENOG4107RCV ABC transporter, permease FORC085_1321 ENOG4105E98 transcriptional regulator DeoR family FORC085_1324 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FORC085_1326 ENOG4105PXI polysaccharide deacetylase FORC085_1328 ENOG4105BZU Histidine kinase FORC085_1329 ENOG41090MY MarR family Transcriptional regulator FORC085_1331 ENOG4106DF1 FORC085_1334 ENOG4105BZU Histidine kinase FORC085_1335 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FORC085_1336 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FORC085_1337 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FORC085_1345 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FORC085_1346 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC085_1347 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC085_1348 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC085_1349 ENOG4105CZV ABC transporter FORC085_1351 ENOG4105CJ1 ABC, transporter FORC085_1359 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FORC085_136 ENOG4108JJB ABC transporter FORC085_1361 ENOG4105EA8 2-Nitropropane dioxygenase FORC085_1362 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC085_1364 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FORC085_1369 ENOG4105NQC Flavodoxin FORC085_137 ENOG4108JJB ABC transporter FORC085_1377 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC085_138 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FORC085_1383 ENOG4105CZN Potassium uptake protein FORC085_1384 ENOG41063Y9 FORC085_1385 ENOG4105KBJ sporulation protein ytfj FORC085_139 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC085_1390 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC085_1391 ENOG4105C7K acetolactate synthase FORC085_1392 ENOG4108ZP8 Acetolactate synthase small subunit FORC085_1393 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC085_1396 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FORC085_1400 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FORC085_1401 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FORC085_1406 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase FORC085_1407 ENOG4107RVV histidinol phosphate phosphatase, hisj family FORC085_1410 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC085_1411 ENOG4105E0M Sulfatase FORC085_1413 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FORC085_1416 ENOG4107S4M Sulfate adenylate transferase FORC085_1417 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FORC085_1418 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FORC085_1420 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC085_1421 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC085_1422 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC085_1423 ENOG4105C8J )-transporter FORC085_1428 ENOG4105DFD Na H antiporter FORC085_1432 ENOG4105ENE Histidine kinase FORC085_1433 ENOG4105WH1 Two component transcriptional regulator luxr family FORC085_1437 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC085_144 ENOG4105D1F ATP-binding protein FORC085_1443 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FORC085_1447 ENOG4105CJ3 phosphate transporter FORC085_1448 ENOG4107GRR phosphate transport regulator FORC085_1449 ENOG4105BZ4 penicillin-binding protein FORC085_1451 ENOG4105BZU Histidine kinase FORC085_1452 ENOG4105I3N Conserved Protein FORC085_1456 ENOG4105BZU Histidine kinase FORC085_1462 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC085_1463 ENOG4105DZ1 carboxypeptidase FORC085_1464 ENOG4108JIC nucleoside recognition domain protein FORC085_1466 ENOG4105FE9 pseudouridine synthase FORC085_1467 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC085_1468 ENOG4107TWT Cytochrome c biogenesis protein FORC085_1469 ENOG4105CRE cytochrome C FORC085_147 ENOG4108NMV polysaccharide deacetylase FORC085_1470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC085_1471 ENOG4105BZU Histidine kinase FORC085_1472 ENOG4108WBT adenosyltransferase FORC085_1475 ENOG4108SAX Membrane FORC085_1478 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC085_1479 ENOG4105I7S Abortive infection protein FORC085_1481 ENOG4107RGJ metallophosphoesterase FORC085_1482 ENOG4108XDN Transcriptional regulator FORC085_1483 ENOG4108S6Z Negative regulator of genetic competence FORC085_1488 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FORC085_1489 ENOG4107RB3 L-asparaginase FORC085_1493 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FORC085_1496 ENOG4105S2F FORC085_1497 ENOG41065D1 FORC085_1504 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FORC085_1507 ENOG4105XXQ heptaprenyl diphosphate synthase component I FORC085_1509 ENOG4105EAH synthase FORC085_151 ENOG4105C8B TIGR00159 family FORC085_1510 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FORC085_1511 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC085_1514 ENOG41068YB TPR repeat-containing protein FORC085_1517 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FORC085_1518 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FORC085_152 ENOG4107U5W ybbr family FORC085_1525 ENOG4108JYZ YitT family FORC085_1527 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FORC085_1530 ENOG4105FJR Lmbe family FORC085_1531 ENOG4105CPK Glycosyl transferase (Group 1 FORC085_1535 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FORC085_1538 ENOG4105DVT helicase FORC085_1539 ENOG4105YAC FORC085_1543 ENOG4105CSM endonuclease III FORC085_1545 ENOG4105BZ4 penicillin-binding protein FORC085_155 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FORC085_1556 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FORC085_1564 ENOG4105DVT helicase FORC085_1565 ENOG4105CTD carboxy-peptidase FORC085_1567 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC085_1568 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FORC085_1569 ENOG4105C2W permease FORC085_1570 ENOG4105DHF Membrane FORC085_1572 ENOG410890F Dynamin family FORC085_1574 ENOG4108W0I acetyltransferase FORC085_1576 ENOG4105KHC sulfurtransferase FORC085_1579 ENOG4106032 Glutathionylspermidine synthase FORC085_1585 ENOG4105HTX biosynthesis protein FORC085_1591 ENOG4105CPK Glycosyl transferase (Group 1 FORC085_1594 ENOG4108SZE gCN5-related N-acetyltransferase FORC085_1598 ENOG41081VK Ribonuclease FORC085_1611 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC085_1613 ENOG4107RWR Sodium hydrogen exchanger FORC085_1614 ENOG4105CN5 Metallo-Beta-Lactamase FORC085_1615 ENOG4108Z5V transcriptional regulator, merr family FORC085_1617 ENOG4105H67 Protein of unknown function (DUF421) FORC085_1618 ENOG41080C8 DUF218 domain FORC085_162 ENOG4108PSK reductase FORC085_1625 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FORC085_1627 ENOG4107R0U MotA TolQ exbB proton channel FORC085_1628 ENOG4105ER2 Ompa motb domain protein FORC085_1629 ENOG4107YTP response regulator receiver protein FORC085_163 ENOG4108UMI ABC transporter, permease FORC085_1630 ENOG4105CBS Chea signal transduction histidine kinase FORC085_1631 ENOG4105DD5 Flagellar motor switch protein FORC085_1634 ENOG4105BZU Histidine kinase FORC085_1638 ENOG4105E1Q flagellar hook-associated protein FORC085_1639 ENOG4105DTJ flagellar hook-associated protein FORC085_164 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC085_1643 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FORC085_1644 ENOG4108ZC9 flagellar basal-body rod protein flgc FORC085_1645 ENOG41075Z6 flagellar hook-basal body complex protein fliE FORC085_1646 ENOG4107U2N Flagellar M-ring protein FORC085_1647 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC085_165 ENOG4105D01 (LipO)protein FORC085_1653 ENOG4105BZE flagellar hook protein, FlgE FORC085_1656 ENOG4107R88 Chemotaxis protein (CheV) FORC085_1659 ENOG4105I03 Flagellin FORC085_1660 ENOG4105I03 Flagellin FORC085_1661 ENOG4105E4C Lytic transglycosylase catalytic FORC085_1663 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC085_1664 ENOG4105DD5 Flagellar motor switch protein FORC085_1666 ENOG4105CN7 Flagellar biosynthetic protein FliP FORC085_1667 ENOG4105VS8 Flagellar biosynthetic protein fliq FORC085_1669 ENOG4105D00 flagellar biosynthetic protein flhB FORC085_167 ENOG4105CB2 alcohol dehydrogenase FORC085_1670 ENOG4105D7B Flagellar biosynthesis protein flha FORC085_1671 ENOG4105FZW flagellar biosynthesis regulator FlhF FORC085_1672 ENOG4105KTQ flagellar basal-body rod protein FORC085_1673 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC085_1680 ENOG4105KAC Antibiotic biosynthesis monooxygenase FORC085_1685 ENOG4105DUM transcriptional regulator, lysR family FORC085_1688 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FORC085_169 ENOG4105IQ5 FAD linked oxidase domain protein FORC085_1695 ENOG4105CVJ phosphoglycerate mutase FORC085_1697 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FORC085_1701 ENOG4105CAQ asparagine synthetase FORC085_1705 ENOG4105PGM cation diffusion facilitator family transporter FORC085_1707 ENOG4105DRR Transcriptional regulator, GntR family FORC085_1708 ENOG4108UZ3 Transporter FORC085_1710 ENOG4105CKI cobalamin synthesis protein FORC085_1711 ENOG4108PJD permease FORC085_1714 ENOG4105DFD Na H antiporter FORC085_1715 ENOG4105VUF Transcriptional regulator FORC085_1717 ENOG4105C9Q fumarate hydratase class II FORC085_172 ENOG4105C2C drug resistance transporter, Bcr CflA FORC085_1721 ENOG4107QJQ Mate efflux family protein FORC085_1722 ENOG4105EC3 peptidase S51, dipeptidase E FORC085_1726 ENOG4107QIV Cytochrome c biogenesis protein FORC085_1727 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC085_1731 ENOG4106BRA Membrane FORC085_1738 ENOG4105CJ1 ABC, transporter FORC085_1743 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC085_1746 ENOG4108IJ0 Aspartate ammonia-lyase FORC085_1747 ENOG4105C6K Malic enzyme FORC085_175 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC085_1756 ENOG41067QW Transcriptional regulator FORC085_176 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC085_1762 ENOG4105FVX FORC085_1763 ENOG4105E09 nadh pyrophosphatase FORC085_1766 ENOG4105CSR polyphosphate kinase 2 FORC085_1769 ENOG4105DXI Major Facilitator superfamily FORC085_177 ENOG4105C3U ABC transporter FORC085_1772 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC085_1773 ENOG4105EU0 Major facilitator Superfamily FORC085_1774 ENOG4105C6T cysteine synthase FORC085_1778 ENOG4105C8J )-transporter FORC085_178 ENOG4108JQ7 (ABC) transporter FORC085_1781 ENOG4105X5K response regulator receiver protein FORC085_1782 ENOG4105H67 Protein of unknown function (DUF421) FORC085_1788 ENOG4105CHR reductase FORC085_1789 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC085_1790 ENOG4105C7K acetolactate synthase FORC085_1792 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC085_1793 ENOG4105C01 Dihydroxy-acid dehydratase FORC085_1794 ENOG4105C7B Threonine dehydratase FORC085_1797 ENOG4105C6X Major Facilitator FORC085_1798 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FORC085_1800 ENOG4105DY9 regulatoR FORC085_1801 ENOG4105CYC Transferase FORC085_1806 ENOG41068WN FORC085_1810 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FORC085_1811 ENOG4105C72 UPF0176 protein FORC085_1813 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FORC085_1815 ENOG4105C0X amino acid FORC085_1823 ENOG410849A acetyltransferase, (GNAT) family FORC085_1827 ENOG4107RHR regulatoR FORC085_1829 ENOG4105D9N nucleoside FORC085_1830 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FORC085_184 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC085_1843 ENOG410811B TRANSCRIPTIONal FORC085_1846 ENOG4107RAQ aminopeptidase FORC085_1848 ENOG4107R16 Multicopper oxidase FORC085_1849 ENOG41061JJ Peptidase family M23 FORC085_185 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC085_1851 ENOG4105MKU Transcriptional regulator FORC085_1860 ENOG4105W8Z 4'-phosphopantetheinyl transferase FORC085_1868 ENOG4105DQ6 Transposase FORC085_187 ENOG4105II7 pyrroline-5-carboxylate reductase FORC085_1870 ENOG4108T5E Copper resistance protein FORC085_1871 ENOG4105KTB nuclear export factor GLE1 FORC085_1872 ENOG4107RT3 EamA-like transporter family FORC085_1873 ENOG4105GZI Transcriptional regulator FORC085_1874 ENOG4108Z40 Transcriptional regulator FORC085_1875 ENOG4107ZXU DSBA oxidoreductase FORC085_1876 ENOG4108TVJ Nitroreductase FORC085_1878 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC085_1879 ENOG4106F5Q Membrane FORC085_1880 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC085_1883 ENOG4105CKI cobalamin synthesis protein FORC085_1885 ENOG4105C0Z ABC transporter FORC085_1886 ENOG4108IV0 ABC, transporter FORC085_1889 ENOG4105SKE transcriptional Regulator LysR family FORC085_1896 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC085_1897 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC085_1898 ENOG4108JJ9 ABC, transporter FORC085_1899 ENOG4108JJ8 (ABC) transporter FORC085_190 ENOG4105E0C molybdate abc transporter FORC085_1901 ENOG4105K64 Glycosyl transferase, family 2 FORC085_1903 ENOG4108UT6 Transferase hexapeptide repeat containing protein FORC085_1914 ENOG4105BZ1 (ABC) transporter FORC085_1915 ENOG4105EFI regulatoR FORC085_1916 ENOG4105BZU Histidine kinase FORC085_1918 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FORC085_1919 ENOG4108ZJ4 polysaccharide deacetylase FORC085_192 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FORC085_1924 ENOG4105D6E homoserine dehydrogenase FORC085_1926 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FORC085_1929 ENOG4108KGH TRANSCRIPTIONal FORC085_1931 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC085_1932 ENOG4105BZU Histidine kinase FORC085_1933 ENOG4107VMI polysaccharide deacetylase FORC085_1935 ENOG4105KT7 mgtC SapB transporter FORC085_1936 ENOG4105VRR gCN5-related N-acetyltransferase FORC085_1938 ENOG4105DUU IucA IucC family protein FORC085_1939 ENOG4105CEY Amp-dependent synthetase and ligase FORC085_194 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FORC085_1942 ENOG4108WBH protein TIM barrel FORC085_1943 ENOG4105YWU small acid-soluble spore protein FORC085_1945 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FORC085_1946 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC085_1956 ENOG4105KRN Transcriptional regulator, abrb family FORC085_1958 ENOG4105YVS arsR family transcriptional regulator FORC085_1960 ENOG4107SET aldo keto reductase FORC085_1961 ENOG4107XZQ multidrug resistance protein FORC085_1963 ENOG4105KAF membrAne FORC085_1968 ENOG4105C8Q Methyl-accepting chemotaxis FORC085_197 ENOG4105EGI Transcriptional regulator FORC085_1971 ENOG4108K88 Membrane FORC085_1972 ENOG4108WPJ Ferritin-like domain FORC085_1975 ENOG4105DEN Luciferase family FORC085_1978 ENOG4105VMI -acetyltransferase FORC085_1979 ENOG4107QM2 Aldo Keto reductase FORC085_1980 ENOG4105CKI cobalamin synthesis protein FORC085_1982 ENOG4105DSE periplasmic solute binding protein FORC085_1984 ENOG4105K4T epimerase FORC085_1986 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC085_1995 ENOG4107T5V SNARE associated Golgi FORC085_1998 ENOG4108PJD permease FORC085_2000 ENOG4108S4H thioesterase Superfamily protein FORC085_2002 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC085_2006 ENOG4105SXS Protein of unknown function (DUF456) FORC085_2007 ENOG4105C37 (CBS) domain FORC085_2011 ENOG4108Z7R Chaperone CsaA FORC085_2014 ENOG4108ZRV stage ii sporulation protein p FORC085_2016 ENOG4108VXD carboxy-peptidase FORC085_2018 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC085_202 ENOG4105F6E Acyl-transferase FORC085_2022 ENOG4108ZRV stage ii sporulation protein p FORC085_2024 ENOG4108X4Q Hydrolase FORC085_2027 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC085_2030 ENOG41087PP glycosyltransferase MGT family FORC085_2031 ENOG4108JYZ YitT family FORC085_2032 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC085_2039 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FORC085_2043 ENOG4106PAW secretion accessory protein EsaA YueB FORC085_2045 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) FORC085_2046 ENOG4108MGT Required for secretion of EsxA and EsxB FORC085_2065 ENOG4105KBJ sporulation protein ytfj FORC085_207 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC085_2070 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC085_2074 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FORC085_2075 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FORC085_2077 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FORC085_2078 ENOG4105EMN RNA polymerase sigma factor FORC085_2081 ENOG4105CNW domain protein FORC085_2083 ENOG4108V06 Glutathione peroxidase FORC085_2086 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC085_2088 ENOG4108IUE nitrate reductase beta subunit FORC085_2089 ENOG4105R3A Nitrate reductase FORC085_2091 ENOG4107V6Q Cyclic nucleotide-binding domain FORC085_2092 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC085_2093 ENOG4105D06 uba thif-type nad fad binding protein FORC085_2094 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC085_2095 ENOG4108ZAF Molybdopterin FORC085_2100 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC085_2101 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC085_2102 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC085_2103 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FORC085_2104 ENOG4108IFG nitrite reductase, (NAD(P)H) FORC085_2105 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FORC085_211 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FORC085_2114 ENOG4105MCT stage V sporulation protein S FORC085_2124 ENOG4105C5H ABC transporter FORC085_2127 ENOG4108UUM single-stranded DNA-binding protein FORC085_2131 ENOG4107YX5 Pfam:DUF548 FORC085_2132 ENOG4105C75 arginyL-tRNA synthetase FORC085_2137 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC085_2142 ENOG4105C5S asparaginyl-tRNA synthetase FORC085_2143 ENOG4105C8J )-transporter FORC085_2147 ENOG4107XGZ Hydrolase FORC085_2148 ENOG4105CY2 Citrate transporter FORC085_2152 ENOG4105KD7 acetyltransferase FORC085_2154 ENOG4105VMP Transcriptional regulator FORC085_2155 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FORC085_216 ENOG4105C5H ABC transporter FORC085_2160 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FORC085_2163 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FORC085_2164 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FORC085_2166 ENOG4107RVG penicillin-binding protein FORC085_2167 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FORC085_2168 ENOG4105E9Q Acyl-transferase FORC085_2169 ENOG4108UT2 hemolysin iii FORC085_2171 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FORC085_2173 ENOG4108RCR degv family FORC085_2176 ENOG4108KF3 Electron transport protein SCO1 SenC FORC085_2177 ENOG4107Y70 Heat shock protein FORC085_2178 ENOG4105CAQ asparagine synthetase FORC085_218 ENOG4105DEF Extracellular solute-binding protein, family 5 FORC085_2181 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC085_2182 ENOG4108MES Periplasmic binding protein FORC085_2183 ENOG4105F0I Aminotransferase FORC085_2189 ENOG4105D8X mechanosensitive ion channel FORC085_2190 ENOG4105BZU Histidine kinase FORC085_2191 ENOG4105WH1 Two component transcriptional regulator luxr family FORC085_2192 ENOG4106KNT transcriptional regulator FORC085_2193 ENOG4107ZY0 Phenazine biosynthesis-like protein FORC085_2197 ENOG4105CMG Carbohydrate kinase FORC085_2198 ENOG4105C6Z Gluconate FORC085_220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC085_2200 ENOG4108YV3 Protein of unknown function (DUF2711) FORC085_2206 ENOG4108IJ8 ABC transporter FORC085_2207 ENOG4105E90 ABC transporter FORC085_221 ENOG4105C3U ABC transporter FORC085_2214 ENOG4105C37 (CBS) domain FORC085_2219 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC085_222 ENOG4108JQ7 (ABC) transporter FORC085_2222 ENOG4107S4Y M20 DapE family protein YgeY FORC085_2223 ENOG4108TSC N-acetyltransferase FORC085_2224 ENOG4108JUB Transcriptional regulator FORC085_2225 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FORC085_223 ENOG410667J hydrolase FORC085_2235 ENOG410841Q phosphoesterase PA-phosphatase related protein FORC085_2236 ENOG4105SZ6 Thioredoxin FORC085_2245 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC085_2256 ENOG4105BZ4 penicillin-binding protein FORC085_2258 ENOG4105CZM Major Facilitator FORC085_2259 ENOG4105W8X HesB YadR YfhF-family protein FORC085_2261 ENOG4105DXD 2-methylcitrate dehydratase FORC085_2262 ENOG4105CR4 methylisocitrate lyase FORC085_2263 ENOG4105C1G acyl-Coa dehydrogenase FORC085_2264 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC085_2266 ENOG4105N14 lysine exporter protein LysE YggA FORC085_2267 ENOG4105E39 Enoyl-CoA hydratase FORC085_2270 ENOG4107RFY SbcCD D subunit FORC085_2271 ENOG4105EYH Exonuclease FORC085_2278 ENOG4105FCD Major Facilitator FORC085_2279 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FORC085_2280 ENOG4105E4F Isochorismate synthase FORC085_2281 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FORC085_2282 ENOG4105WQI isochorismatase FORC085_2283 ENOG4105CEY Amp-dependent synthetase and ligase FORC085_2284 ENOG4105WQT MbtH domain protein FORC085_2285 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC085_2288 ENOG4105K70 DNA-binding protein FORC085_229 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FORC085_2292 ENOG4105BZG amino acid carrier protein FORC085_2299 ENOG4105FE9 pseudouridine synthase FORC085_230 ENOG4105ERH Fumarylacetoacetate hydrolase FORC085_2300 ENOG4105C22 threonyL-tRNA synthetase FORC085_2301 ENOG4105C19 ABC transporter FORC085_2313 ENOG41081I9 integral membrane protein FORC085_2315 ENOG4108Y4K DNA-binding transcriptional activator FORC085_2318 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC085_232 ENOG4105CUB amino acid FORC085_2320 ENOG4105EYF MMPL domain protein FORC085_2324 ENOG4105WCN acetyltransferase FORC085_2329 ENOG4105C1Q protoporphyrinogen oxidase FORC085_233 ENOG4108SC4 )-transporter FORC085_2331 ENOG41068WN FORC085_2337 ENOG4107V2S Transcriptional regulator FORC085_2338 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC085_234 ENOG4105CPF Cell wall formation (By similarity) FORC085_2342 ENOG4105DND Transcriptional regulator FORC085_2343 ENOG4108RPX mosc domain containing protein FORC085_2346 ENOG4105BZ1 (ABC) transporter FORC085_2347 ENOG4105BZ1 (ABC) transporter FORC085_235 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FORC085_2355 ENOG4108JCI Transcriptional regulator FORC085_2362 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FORC085_2363 ENOG4108KPJ rna polymerase sigma factor FORC085_2368 ENOG4105F32 YngK protein FORC085_2372 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FORC085_2373 ENOG4105RD7 BadF BadG BcrA BcrD FORC085_2374 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC085_2376 ENOG4105C7B Threonine dehydratase FORC085_2377 ENOG4108INS Transcriptional regulator FORC085_2380 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC085_2382 ENOG4105C1J atp-dependent rna helicase FORC085_2387 ENOG4108IG5 Transcriptional regulator FORC085_2391 ENOG41088CC tellurite resistance protein tehB FORC085_2393 ENOG4108I0C methyltransferase FORC085_2394 ENOG4107RA9 decarboxylase FORC085_2395 ENOG41090HR transcriptional regulator FORC085_240 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FORC085_2401 ENOG4105CIN aminoacyl-histidine dipeptidase FORC085_2403 ENOG4105DQ6 Transposase FORC085_2409 ENOG4105KRN Transcriptional regulator, abrb family FORC085_241 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC085_2411 ENOG4105EJ9 Membrane FORC085_2412 ENOG4105EQK -acetyltransferase FORC085_2420 ENOG4105W8Z 4'-phosphopantetheinyl transferase FORC085_2422 ENOG4105CHR reductase FORC085_243 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FORC085_2442 ENOG4105FQP Beta-lactamase FORC085_2443 ENOG4107RVG penicillin-binding protein FORC085_2446 ENOG4107RF6 penicillin-binding protein FORC085_2447 ENOG4107RF6 penicillin-binding protein FORC085_2449 ENOG4105DIN metallophosphoesterase FORC085_2451 ENOG4105CJ1 ABC, transporter FORC085_2453 ENOG4107Z3H Transcriptional regulator, TetR family FORC085_2456 ENOG4105C1G acyl-Coa dehydrogenase FORC085_2457 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC085_2458 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FORC085_2459 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FORC085_2460 ENOG4105E39 Enoyl-CoA hydratase FORC085_2461 ENOG4107QX3 carboxylase FORC085_2462 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC085_2467 ENOG4105DBI uridine monophosphokinase FORC085_247 ENOG4105K8N protein family UPF0079, ATPase FORC085_2470 ENOG4105DZ1 carboxypeptidase FORC085_2474 ENOG4105T9C HD domain FORC085_2476 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FORC085_248 ENOG41072GX Peptidase M22 Glycoprotease FORC085_2480 ENOG41075H3 AraC family transcriptional regulator FORC085_2486 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC085_2488 ENOG4105CHR reductase FORC085_2489 ENOG4105KVH Transcriptional regulator FORC085_249 ENOG410801F ribosomal-protein-alanine acetyltransferase FORC085_2493 ENOG4105MDS 4-oxalocrotonate tautomerase FORC085_2494 ENOG4107V2S Transcriptional regulator FORC085_250 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC085_2500 ENOG4105EFA 4-hydroxyphenylacetate FORC085_2503 ENOG4105CPQ Dehydrogenase FORC085_2505 ENOG410900G Protein of unknown function (DUF421) FORC085_2506 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FORC085_2509 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FORC085_251 ENOG4105C5H ABC transporter FORC085_2521 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FORC085_2528 ENOG4105D6E homoserine dehydrogenase FORC085_2530 ENOG4105CPF Cell wall formation (By similarity) FORC085_2531 ENOG4105ETU transcriptional activator (TenA FORC085_254 ENOG4108TYN CAAX amino terminal protease family protein FORC085_2550 ENOG410667J hydrolase FORC085_2551 ENOG4105BZU Histidine kinase FORC085_2552 ENOG4107RF6 penicillin-binding protein FORC085_2557 ENOG4108JJB ABC transporter FORC085_2560 ENOG4108HGU Histidine kinase FORC085_2574 ENOG4105CB2 alcohol dehydrogenase FORC085_2575 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FORC085_2576 ENOG4105CJN penicillin-binding protein FORC085_258 ENOG4105C7N Xanthine uracil vitamin C permease FORC085_2588 ENOG4107Y80 Major Facilitator superfamily FORC085_2589 ENOG4108Z5V transcriptional regulator, merr family FORC085_2594 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC085_2599 ENOG4107Y9U Membrane FORC085_260 ENOG4105BZU Histidine kinase FORC085_2608 ENOG4105FCD Major Facilitator FORC085_2610 ENOG4105E09 nadh pyrophosphatase FORC085_2611 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC085_2615 ENOG4108XI2 Domain of unknown function (DUF1963) FORC085_2619 ENOG4105D78 K07001 NTE family protein FORC085_262 ENOG4107ZXU DSBA oxidoreductase FORC085_2620 ENOG4105KWG Pfam:DUF1696 FORC085_2622 ENOG4108YYS metal-dependent hydrolase (By similarity) FORC085_2625 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC085_2627 ENOG4105PKS Excinuclease abc c subunit domain protein FORC085_2635 ENOG4107VFR oxidoreductase FORC085_2642 ENOG4105U0R haloacid dehalogenase-like hydrolase FORC085_2643 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC085_2644 ENOG4105BZU Histidine kinase FORC085_2648 ENOG4107WD8 ABC transporter, permease FORC085_2651 ENOG4105DY8 decarboxylase FORC085_2654 ENOG4108IUM Glycogen debranching enzyme FORC085_2656 ENOG4105CGH 5'-nucleotidase FORC085_2660 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC085_2661 ENOG4105FDR Membrane FORC085_2663 ENOG4105CIS alcohol dehydrogenase FORC085_2664 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FORC085_2673 ENOG4105MSI germination protein ypeb FORC085_2679 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FORC085_268 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC085_2680 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FORC085_2681 ENOG4107Z3H Transcriptional regulator, TetR family FORC085_2686 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FORC085_2690 ENOG4105E98 transcriptional regulator DeoR family FORC085_2693 ENOG41062ES Transcriptional regulator FORC085_2697 ENOG4107QKR Dehydrogenase FORC085_2699 ENOG4107RUY (E1 component), alpha subunit FORC085_2702 ENOG4105E1F short-chain dehydrogenase reductase FORC085_2703 ENOG4105RHY Pfam:UPF0157 FORC085_271 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC085_2710 ENOG4107SQ8 Glycine betaine FORC085_2711 ENOG4108IJ7 Glycine betaine FORC085_2713 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FORC085_2716 ENOG4105E66 phosphoriboisomerase A FORC085_2717 ENOG41082BV acetyltransferase FORC085_2718 ENOG4108M1A Chitin-binding protein FORC085_2724 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC085_2725 ENOG4105MSB protein, conserved in bacteria FORC085_273 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FORC085_2730 ENOG4108Z7F N-acetyltransferase FORC085_2736 ENOG4105EEM helicase FORC085_2739 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC085_275 ENOG4108SHN Glycosyl transferase, family 2 FORC085_2750 ENOG4108M1A Chitin-binding protein FORC085_2753 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC085_2755 ENOG4105BZG amino acid carrier protein FORC085_2756 ENOG4105C26 Dehydrogenase FORC085_2757 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC085_2758 ENOG4105CTU Proline racemase FORC085_2759 ENOG4105CTU Proline racemase FORC085_276 ENOG4105SX7 Transporter FORC085_2760 ENOG41080HI glycine oxidase FORC085_2762 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FORC085_2769 ENOG4105DCI Phosphohydrolase FORC085_2770 ENOG4107T5V SNARE associated Golgi FORC085_2772 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC085_2776 ENOG4105DTQ mandelate racemase muconate lactonizing FORC085_2779 ENOG4107SET aldo keto reductase FORC085_2786 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FORC085_2787 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC085_2788 ENOG4105BZU Histidine kinase FORC085_2789 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC085_279 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FORC085_2793 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FORC085_2796 ENOG4105DPN Oligoendopeptidase f FORC085_2797 ENOG4105EPR degv family FORC085_280 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FORC085_281 ENOG4105C83 adenylosuccinate lyase FORC085_2810 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC085_2811 ENOG4106K7D Major facilitator family transporter FORC085_2815 ENOG4107BMA Transglycosylase associated protein FORC085_2818 ENOG41089UC methyltransferase, type 11 FORC085_2827 ENOG4105CHM Aminotransferase FORC085_283 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FORC085_2830 ENOG4108ZMI UPF0477 protein FORC085_2833 ENOG4105DVE abc transporter atp-binding protein FORC085_2844 ENOG4105C02 permease FORC085_2847 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FORC085_2848 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FORC085_2849 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FORC085_2850 ENOG4105D7T ABC transporter FORC085_2857 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FORC085_2864 ENOG4107VC0 DNA alkylation repair enzyme FORC085_2866 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC085_2867 ENOG4107VMI polysaccharide deacetylase FORC085_2869 ENOG4108ZCF integral membrane protein FORC085_2870 ENOG4105E0M Sulfatase FORC085_2871 ENOG4105C5H ABC transporter FORC085_2873 ENOG4105EYF MMPL domain protein FORC085_2874 ENOG41082JN Transcriptional regulator FORC085_2878 ENOG4105CIH Imidazole acetol-phosphate transaminase FORC085_2879 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC085_2880 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC085_2889 ENOG41069ER domain protein FORC085_289 ENOG4108V3E phosphoribosylglycinamide formyltransferase FORC085_2891 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FORC085_2892 ENOG4105DNP FAD linked oxidase domain protein FORC085_2898 ENOG4105F5R ABC transporter FORC085_2899 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FORC085_2901 ENOG4105DKT Transcriptional regulator FORC085_2902 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FORC085_2904 ENOG41061GT Aldolase FORC085_2907 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FORC085_291 ENOG4105C12 Phosphoribosylglycinamide synthetase FORC085_2914 ENOG4105II7 pyrroline-5-carboxylate reductase FORC085_2916 ENOG4107258 Transcriptional regulator FORC085_2919 ENOG4105ECK Fatty Acid Desaturase FORC085_2922 ENOG4107RBI VanW family FORC085_2923 ENOG4105G6Z alkaline phosphatase FORC085_2925 ENOG4105VMP Transcriptional regulator FORC085_2929 ENOG41068WN FORC085_2935 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC085_2940 ENOG4105CKK Glycosyl transferase, family 2 FORC085_2946 ENOG4105C8Y Acetylornithine aminotransferase FORC085_2955 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC085_2959 ENOG4108IBT Inherit from COG: transposase FORC085_296 ENOG4105C4R Atp-dependent dna helicase FORC085_2963 ENOG4108TVJ Nitroreductase FORC085_2964 ENOG4105FS7 Transcriptional regulator FORC085_2967 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC085_2972 ENOG4108DMH HTH_ARAC FORC085_2973 ENOG4108XET gCN5-related N-acetyltransferase FORC085_2976 ENOG4108PCN EamA-like transporter family FORC085_2980 ENOG4107XJU UPF0178 protein FORC085_2987 ENOG410635A Membrane FORC085_2989 ENOG4108IQI permease FORC085_2991 ENOG4105F1N DNA alkylation repair FORC085_2999 ENOG4107RF6 penicillin-binding protein FORC085_3000 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FORC085_3001 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) FORC085_3004 ENOG4105E7W lamb ycsf family protein FORC085_3006 ENOG4105P4J Allophanate hydrolase, subunit 1 FORC085_3007 ENOG4107258 Transcriptional regulator FORC085_3009 ENOG4106N3A copper homeostasis protein cutc FORC085_301 ENOG4108W2Y isochorismatase FORC085_3010 ENOG4108ZHR arsR family transcriptional regulator FORC085_3012 ENOG4105FDT acyl-CoA dehydrogenase FORC085_3016 ENOG4105DWD nucleoside recognition domain protein FORC085_302 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC085_3026 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FORC085_303 ENOG4108UMI ABC transporter, permease FORC085_3032 ENOG4105E2A Dehydrogenase FORC085_3034 ENOG4108IJ0 Aspartate ammonia-lyase FORC085_3035 ENOG4105HDK L-asparaginase FORC085_3036 ENOG4108IMY Transcriptional regulator FORC085_3038 ENOG4108B31 Spore germination protein FORC085_304 ENOG4105D01 (LipO)protein FORC085_3040 ENOG4105BZU Histidine kinase FORC085_3045 ENOG41075H3 AraC family transcriptional regulator FORC085_3047 ENOG4105YWU small acid-soluble spore protein FORC085_3048 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC085_3049 ENOG4105CUB amino acid FORC085_3050 ENOG4105II7 pyrroline-5-carboxylate reductase FORC085_3051 ENOG4108NHD germination protein FORC085_3052 ENOG4108Q8B Spore germination protein FORC085_3057 ENOG4105CSV Glutaminase FORC085_3062 ENOG4106A3M Cytochrome p-450 FORC085_3065 ENOG4105CGH 5'-nucleotidase FORC085_3067 ENOG4105CHJ isochorismatase hydrolase FORC085_3071 ENOG4107RSM transcriptional regulator FORC085_3072 ENOG41090MY MarR family Transcriptional regulator FORC085_3077 ENOG4105F6J Alpha beta hydrolase fold FORC085_308 ENOG410834F Transcriptional regulator FORC085_3080 ENOG4108606 TspO/MBR family FORC085_3081 ENOG4105CVP deoxyribo-dipyrimidine photolyase FORC085_3086 ENOG4108TWJ NADH dehydrogenase subunit 5 FORC085_3087 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FORC085_3088 ENOG4107VMI polysaccharide deacetylase FORC085_3089 ENOG4105KY5 gCN5-related N-acetyltransferase FORC085_309 ENOG4107I77 yiaA/B two helix domain FORC085_3090 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC085_3092 ENOG4105Z7P Acetyltransferase (GNAT) family FORC085_3094 ENOG4105D6J arsenicaL-resistance protein FORC085_3095 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC085_3096 ENOG41085FC arsR family transcriptional regulator FORC085_3099 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC085_3100 ENOG4107P5I polyketide synthase FORC085_3101 ENOG4108IG5 Transcriptional regulator FORC085_3110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC085_3111 ENOG41062D9 Histidine kinase FORC085_3119 ENOG4105DNP FAD linked oxidase domain protein FORC085_3121 ENOG4105C19 ABC transporter FORC085_3127 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FORC085_3128 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC085_313 ENOG4105CBD Diacylglycerol kinase FORC085_3132 ENOG4105K6H D-cysteine desulfhydrase FORC085_3137 ENOG4108NNI Beta-lactamase domain-containing protein FORC085_3138 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FORC085_3140 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FORC085_3141 ENOG4105JQZ Methyltransferase FORC085_3145 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FORC085_3149 ENOG4105BZU Histidine kinase FORC085_315 ENOG4108JPW Aminotransferase FORC085_3152 ENOG4108U05 Transcriptional regulator FORC085_3153 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FORC085_3155 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC085_3162 ENOG4108JQ1 Dehydrogenase FORC085_3163 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FORC085_317 ENOG4105C26 Dehydrogenase FORC085_3170 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC085_318 ENOG4105KPY Small multidrug resistance protein FORC085_3204 ENOG4108VXD carboxy-peptidase FORC085_3205 ENOG4105PNM synthesis protein FORC085_3207 ENOG4108ISG Major Facilitator FORC085_3210 ENOG4107MII Sugar-specific transcriptional regulator TrmB FORC085_3211 ENOG4105CZM Major Facilitator FORC085_3214 ENOG4105CRW Short chain fatty acid transporter FORC085_3216 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC085_3228 ENOG4108K8S endonuclease I FORC085_3234 ENOG4108Z66 YbaK ebsC protein FORC085_3235 ENOG4105CUT histidyl-tRNA synthetase FORC085_3238 ENOG4105KVH Transcriptional regulator FORC085_3239 ENOG4108RCM Nitroreductase FORC085_324 ENOG4105D9N nucleoside FORC085_3245 ENOG4108PSK reductase FORC085_325 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC085_3258 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC085_3259 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC085_3266 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FORC085_327 ENOG4108W15 Protein of unknown function (DUF1456) FORC085_3274 ENOG4105C37 (CBS) domain FORC085_3277 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC085_3278 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC085_3281 ENOG4108SMP Nad-dependent epimerase dehydratase FORC085_3285 ENOG4105DDN Pentapeptide repeat-containing protein FORC085_3286 ENOG4105XDF Protein of unknown function (DUF1272) FORC085_3287 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FORC085_3288 ENOG4105CMG Carbohydrate kinase FORC085_3289 ENOG4105C6Z Gluconate FORC085_3290 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC085_3293 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FORC085_330 ENOG4105DTQ mandelate racemase muconate lactonizing FORC085_3301 ENOG4105C44 Serine transporter FORC085_3306 ENOG4108TZY GntR Family Transcriptional Regulator FORC085_3307 ENOG4105D9R oxidoreductase FORC085_331 ENOG4105DFD Na H antiporter FORC085_3316 ENOG4105JAB phenazine biosynthesis protein, phzf family FORC085_3318 ENOG4105CHR reductase FORC085_3320 ENOG4105KNA -acetyltransferase FORC085_3322 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FORC085_3323 ENOG4105KVH Transcriptional regulator FORC085_3326 ENOG4108ZJ4 polysaccharide deacetylase FORC085_3341 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FORC085_3344 ENOG4107YXZ hydrolase, family 25 FORC085_3351 ENOG4105H3G oxidoreductase FORC085_336 ENOG4105D3R alkyl hydroperoxide reductase FORC085_3366 ENOG4108TN2 lmbE family FORC085_3368 ENOG4107R3E Citrate transporter FORC085_337 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FORC085_3370 ENOG4105WCN acetyltransferase FORC085_3371 ENOG4108MES Periplasmic binding protein FORC085_3372 ENOG4105EHG Permease protein FORC085_3373 ENOG4105DQ5 transport system permease protein FORC085_3374 ENOG4105NX3 Membrane FORC085_3378 ENOG41068WN FORC085_3379 ENOG4107CUJ Protein of unknown function (DUF2690) FORC085_338 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FORC085_3382 ENOG4107V2S Transcriptional regulator FORC085_3388 ENOG4105C98 muts2 protein FORC085_3389 ENOG4105E5K Alpha-amylase FORC085_339 ENOG4107W7X Aldolase FORC085_3390 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FORC085_3391 ENOG4105DPN Oligoendopeptidase f FORC085_3397 ENOG4108A04 Beta-lactamase FORC085_340 ENOG4105EHG Permease protein FORC085_3402 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC085_3405 ENOG41082BM Transcriptional regulator, arsr family FORC085_3406 ENOG4105CIS alcohol dehydrogenase FORC085_341 ENOG4105DQ5 transport system permease protein FORC085_3412 ENOG4105CQB FAD linked oxidase domain protein FORC085_3417 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC085_342 ENOG4108V5C ABC transporter FORC085_3421 ENOG4105CEP NADH dehydrogenase FORC085_3423 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FORC085_3424 ENOG4108M1A Chitin-binding protein FORC085_3426 ENOG4105E1K spore germination protein FORC085_343 ENOG4105CAY ferredoxin--nadp reductase FORC085_3430 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC085_3432 ENOG4108IAJ Nad-dependent epimerase dehydratase FORC085_3433 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC085_3449 ENOG4105BZU Histidine kinase FORC085_3450 ENOG4105C5H ABC transporter FORC085_3452 ENOG4107DUR UPF0457 protein FORC085_3457 ENOG4105BZU Histidine kinase FORC085_3459 ENOG4105KT7 mgtC SapB transporter FORC085_3461 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC085_3463 ENOG41073R8 VanW family FORC085_3465 ENOG4108R1P FORC085_3469 ENOG4105VEQ Cold shock protein FORC085_347 ENOG4106UIA FORC085_3473 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC085_3477 ENOG410904N short-chain dehydrogenase reductase FORC085_3479 ENOG4106IQC argininosuccinate lyase FORC085_348 ENOG4106UIA FORC085_3482 ENOG4108IA2 Sodium pantothenate symporter FORC085_3484 ENOG4105C26 Dehydrogenase FORC085_3485 ENOG4105CHR reductase FORC085_3487 ENOG4105EWU Squalene--hopene cyclase FORC085_3489 ENOG4105FR1 rard protein FORC085_3490 ENOG410696E Membrane FORC085_3492 ENOG4105DQ6 Transposase FORC085_3495 ENOG4105D1F ATP-binding protein FORC085_3497 ENOG4108ZAF Molybdopterin FORC085_3498 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC085_3499 ENOG4105D06 uba thif-type nad fad binding protein FORC085_3500 ENOG4105TMB Formate nitrite transporter FORC085_3502 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC085_3503 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FORC085_3505 ENOG4108JB9 formate dehydrogenase FORC085_3506 ENOG4105E1K spore germination protein FORC085_3509 ENOG4105CUB amino acid FORC085_351 ENOG4105BZU Histidine kinase FORC085_3521 ENOG4107QJT sodium dicarboxylate symporter FORC085_3522 ENOG4108KGH TRANSCRIPTIONal FORC085_3524 ENOG4105EMN RNA polymerase sigma factor FORC085_3526 ENOG4105CIG ABC transporter FORC085_3528 ENOG4105D9R oxidoreductase FORC085_3530 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC085_3531 ENOG4105K4P CoA-binding domain protein FORC085_3532 ENOG4105C0H protease FORC085_3533 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC085_3535 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FORC085_3536 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC085_3537 ENOG4105W8X HesB YadR YfhF-family protein FORC085_3543 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC085_3544 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC085_3547 ENOG4105BZ1 (ABC) transporter FORC085_3548 ENOG4108I0Z Aconitate hydratase FORC085_355 ENOG410756H nucleotidyltransferase FORC085_3554 ENOG4105E5W Transporter FORC085_3556 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC085_356 ENOG4105D2S major facilitator superfamily FORC085_3560 ENOG4107F3J Amp-dependent synthetase and ligase FORC085_3561 ENOG4107ZYJ bioY protein FORC085_3562 ENOG4105CEY Amp-dependent synthetase and ligase FORC085_3571 ENOG4107AYK membrAne FORC085_3574 ENOG4105BZU Histidine kinase FORC085_3575 ENOG4105FBA Phospholipase Carboxylesterase FORC085_3576 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FORC085_3577 ENOG4105CK7 Sodium proline symporter FORC085_3579 ENOG4105CBC glutamate synthase FORC085_3580 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FORC085_3581 ENOG4108VJ1 Transcriptional regulator (CarD family FORC085_3582 ENOG4108903 Formimidoylglutamase FORC085_359 ENOG4105E5Q amino acid AbC transporter FORC085_3593 ENOG4107QIV Cytochrome c biogenesis protein FORC085_3597 ENOG4105CH2 amidohydrolase FORC085_3599 ENOG4105CJ1 ABC, transporter FORC085_360 ENOG4105EAB amino acid AbC transporter FORC085_3602 ENOG4107RSM transcriptional regulator FORC085_3603 ENOG4105VAW lrga family FORC085_3604 ENOG41067MG lrgb family FORC085_3612 ENOG4105BZ1 (ABC) transporter FORC085_3613 ENOG4105BZ1 (ABC) transporter FORC085_362 ENOG4105C8Q Methyl-accepting chemotaxis FORC085_3622 ENOG4105CGH 5'-nucleotidase FORC085_3624 ENOG4108SVB resolvase FORC085_3628 ENOG4105K7K Transcriptional regulator FORC085_3630 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FORC085_3631 ENOG4105DR5 peptidase FORC085_3632 ENOG41065S2 pneumococcal vaccine antigen FORC085_3639 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FORC085_3640 ENOG4105C5F glutamine synthetase FORC085_3641 ENOG4105KV4 Transcriptional regulator FORC085_3642 ENOG4105CXI aluminum resistance protein FORC085_3643 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC085_3644 ENOG4105EN6 Membrane FORC085_3646 ENOG4106F1P AAA ATPase, central domain protein FORC085_365 ENOG4105DBV ornithine carbamoyltransferase FORC085_3652 ENOG41069ER domain protein FORC085_3653 ENOG4105DM4 PTS System FORC085_3654 ENOG4105DE4 1-phosphofructokinase FORC085_3655 ENOG4105E98 transcriptional regulator DeoR family FORC085_3656 ENOG4107QW4 alcohol dehydrogenase FORC085_3657 ENOG4108SJC Membrane FORC085_3660 ENOG4105C85 amino acid FORC085_3663 ENOG4105TMB Formate nitrite transporter FORC085_3664 ENOG4105K70 DNA-binding protein FORC085_3666 ENOG4105C59 p-type ATPase FORC085_3667 ENOG410681U heavy metal transport detoxification protein FORC085_3668 ENOG4105VPX protein, conserved in bacteria FORC085_367 ENOG4105C5B carbamate kinase FORC085_3671 ENOG4105DQ6 Transposase FORC085_3672 ENOG4105NIV Esterase FORC085_3673 ENOG4105E0A ABC, transporter FORC085_3679 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC085_368 ENOG4108W63 CRP FNR family transcriptional regulator FORC085_3680 ENOG4105D03 DNA-3-methyladenine glycosylase II FORC085_3681 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC085_3686 ENOG4105BZU Histidine kinase FORC085_3694 ENOG41067MG lrgb family FORC085_3698 ENOG4108S3Y transcriptional regulator FORC085_3699 ENOG4105CS2 ec 3.2.1.21 FORC085_370 ENOG4105DNP FAD linked oxidase domain protein FORC085_3702 ENOG4105F0V Cell wall hydrolase FORC085_3704 ENOG4105E0M Sulfatase FORC085_3705 ENOG410890F Dynamin family FORC085_3712 ENOG4105DQU oxidoreductase, subunit beta FORC085_3713 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FORC085_3714 ENOG4108IGT Dipeptidase FORC085_3715 ENOG4105MCT stage V sporulation protein S FORC085_3716 ENOG4105D48 metallophosphoesterase FORC085_372 ENOG4105CI1 PTS System FORC085_3720 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FORC085_3723 ENOG4105XZV Protein of unknown function (DUF3243) FORC085_3724 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FORC085_3728 ENOG4105UIB (ABC) transporter FORC085_3729 ENOG4108JQ9 ABC transporter FORC085_3730 ENOG4105DIH basic membrane FORC085_3731 ENOG4105FDP GntR family transcriptional regulator FORC085_3732 ENOG4105CNU cell division protein FtsK FORC085_3734 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FORC085_3736 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC085_3738 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC085_3739 ENOG4108S0H Dipicolinic acid synthetase, b subunit FORC085_3740 ENOG4105E35 Dipicolinate synthase subunit A FORC085_3742 ENOG4105C1V Peptidase, M16 FORC085_3746 ENOG4105DTN riboflavin biosynthesis protein ribF FORC085_3749 ENOG4105W7A Protein of unknown function (DUF503) FORC085_375 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC085_3751 ENOG4105VHM ribosomal protein FORC085_3752 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FORC085_3753 ENOG4105CHV Transcription elongation factor NusA FORC085_3755 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC085_3757 ENOG4105DZP Membrane-associated zinc metalloprotease FORC085_3758 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC085_3759 ENOG4105KNE Phosphatidate cytidylyltransferase FORC085_3760 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FORC085_3762 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC085_3768 ENOG4108HE4 integrase family FORC085_3770 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FORC085_3771 ENOG4105C79 DNA protecting protein DprA FORC085_3772 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FORC085_3775 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FORC085_378 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FORC085_3780 ENOG4105VB6 UPF0109 protein FORC085_3784 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FORC085_3785 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FORC085_3788 ENOG4105CHR reductase FORC085_3789 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FORC085_3792 ENOG4105CB5 ATP-dependent DNA helicase recG FORC085_3793 ENOG4105DP4 dak2 domain fusion protein ylov FORC085_3794 ENOG4108ZAA Alkaline-shock protein FORC085_3797 ENOG4105FJ0 thiamine FORC085_3798 ENOG4105DJV ribulose-phosphate 3-epimerase FORC085_3799 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC085_3800 ENOG4105D9P serine threonine protein kinase FORC085_3801 ENOG4108ZF3 Phosphatase FORC085_3803 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FORC085_3806 ENOG4105C25 Primosomal protein n' FORC085_3807 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FORC085_3811 ENOG4105DSJ YicC domain protein FORC085_3813 ENOG4105F23 Fibronectin-binding protein FORC085_3814 ENOG4105DC7 peptidase M24 FORC085_3819 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FORC085_382 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC085_3822 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FORC085_3823 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FORC085_3825 ENOG4105CD3 dihydroorotase FORC085_3829 ENOG4105C34 Pseudouridine synthase FORC085_383 ENOG4105D2X ABC transporter substrate-binding protein FORC085_3832 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC085_3834 ENOG4105DBK s4 domain protein FORC085_3835 ENOG41067XK integral membrane protein FORC085_3837 ENOG4105DFA alanine racemase domain protein FORC085_3838 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FORC085_3839 ENOG4105WR5 sporulation protein, YlmC YmxH family FORC085_3841 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC085_3843 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FORC085_3844 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FORC085_3847 ENOG4105D4A Cell wall formation (By similarity) FORC085_3848 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC085_3849 ENOG4105CNI cell division protein FtsW FORC085_385 ENOG4105C5H ABC transporter FORC085_3852 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FORC085_3853 ENOG4105CJN penicillin-binding protein FORC085_3854 ENOG4105CJN penicillin-binding protein FORC085_3857 ENOG41074B2 UPF0747 protein FORC085_3862 ENOG4105KNH Nucleic acid-binding protein FORC085_3864 ENOG41063PX domain protein FORC085_3865 ENOG4105D78 K07001 NTE family protein FORC085_3867 ENOG4105H20 Sporulation integral membrane protein YlbJ FORC085_3868 ENOG4106H78 methyltransferase FORC085_3872 ENOG4107TB6 phosphoglycerate mutase FORC085_3875 ENOG4106UY4 Inherit from COG: Scp-like extracellular FORC085_3887 ENOG4105CNI cell division protein FtsW FORC085_3890 ENOG4108IAB Phoh family FORC085_3894 ENOG4105QA2 FORC085_3895 ENOG4105CI3 gtp-binding protein typa FORC085_3897 ENOG4105ECY inositol monophosphatase FORC085_3901 ENOG4105CXN decarboxylase FORC085_391 ENOG41062JF Transcriptional regulator FORC085_3911 ENOG4105CPP Dehydrogenase, E1 component FORC085_3914 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FORC085_3915 ENOG4108X4Q Hydrolase FORC085_3917 ENOG4105CN5 Metallo-Beta-Lactamase FORC085_3918 ENOG4107ZYR domain protein FORC085_3925 ENOG4108XRC Protein of unknown function (DUF458) FORC085_3927 ENOG4107IN1 Protein of unknown function (DUF1797) FORC085_3931 ENOG4105EPM Diguanylate phosphodiesterase FORC085_3932 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FORC085_3935 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FORC085_3937 ENOG4105UIN FORC085_394 ENOG4105DEU major facilitator superfamily FORC085_3949 ENOG4108HGU Histidine kinase FORC085_3952 ENOG4105CHM Aminotransferase FORC085_3953 ENOG4105FKQ transcriptional regulator FORC085_3954 ENOG4105EG2 ABC transporter, permease FORC085_3956 ENOG4107FKK extracellular solute-binding protein family 1 FORC085_3958 ENOG4105CG3 alpha amylase, catalytic region FORC085_3967 ENOG4105CHU acetyl-coa acetyltransferase FORC085_397 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FORC085_3974 ENOG4105K7K Transcriptional regulator FORC085_3975 ENOG4105DTD Dehydrogenase FORC085_3979 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FORC085_3984 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FORC085_3987 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC085_3989 ENOG4105BZU Histidine kinase FORC085_3993 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FORC085_3996 ENOG4105CID antiterminator FORC085_3998 ENOG4105FDP GntR family transcriptional regulator FORC085_400 ENOG4108N0M stress protein FORC085_4000 ENOG4105CE4 GlcNAc 6-P deacetylase FORC085_4007 ENOG4107ZE5 PPIases accelerate the folding of proteins FORC085_4008 ENOG4105PTM secreted protein FORC085_4009 ENOG4105J7I hydrolase FORC085_401 ENOG4106FN3 tellurium resistance protein FORC085_4011 ENOG4105G6R Stage v sporulation protein ae FORC085_4013 ENOG4105CZ3 stage V sporulation protein ad FORC085_4014 ENOG41090VF Stage v sporulation protein ac FORC085_4018 ENOG4105C8J )-transporter FORC085_4019 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC085_402 ENOG4106FN3 tellurium resistance protein FORC085_4021 ENOG41082AN stage II sporulation protein FORC085_4022 ENOG4105DZ1 carboxypeptidase FORC085_4023 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC085_4024 ENOG4105DVE abc transporter atp-binding protein FORC085_403 ENOG4107TS3 membrane protein, TerC FORC085_4031 ENOG4105D7N magnesium and cobalt transport protein CorA FORC085_4036 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FORC085_4038 ENOG4105I3K Ferric uptake regulator, Fur family FORC085_4039 ENOG4105MZ9 stage II sporulation protein m FORC085_404 ENOG4108TTB tellurium resistance protein FORC085_4043 ENOG4105CPC Aldo Keto reductase FORC085_4045 ENOG4105RHY Pfam:UPF0157 FORC085_4049 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FORC085_4051 ENOG4105ETE Transcriptional regulator (LacI family FORC085_4052 ENOG4108YM7 Gcn5-related n-acetyltransferase FORC085_4056 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FORC085_4057 ENOG4108R6K riboflavin synthase, subunit alpha FORC085_4062 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC085_4063 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FORC085_4065 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FORC085_4066 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC085_4068 ENOG4105DFD Na H antiporter FORC085_4069 ENOG4105DQ6 Transposase FORC085_407 ENOG41068PA UPF0435 protein FORC085_4071 ENOG4105CGH 5'-nucleotidase FORC085_4076 ENOG4105DBV ornithine carbamoyltransferase FORC085_4079 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FORC085_408 ENOG4105KJF protein tyrosine phosphatase FORC085_4082 ENOG4108IXY short-chain dehydrogenase reductase FORC085_4083 ENOG41069FQ Metallo-beta-lactamase superfamily FORC085_4084 ENOG4105II7 pyrroline-5-carboxylate reductase FORC085_4085 ENOG4105EJQ L-serine dehydratase FORC085_4091 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FORC085_4094 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC085_4095 ENOG4105D9U N-acetyltransferase FORC085_4098 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FORC085_4099 ENOG4108QEG Membrane FORC085_410 ENOG4107U9T Pfam:Ribonuclease_BN FORC085_4100 ENOG4105CDA abc transporter atp-binding protein FORC085_4101 ENOG4105E5Q amino acid AbC transporter FORC085_4102 ENOG4108HW3 (ABC) transporter FORC085_4104 ENOG4105G7B Protein of unknown function (DUF2992) FORC085_4105 ENOG4105E09 nadh pyrophosphatase FORC085_4106 ENOG4108QY0 Membrane FORC085_4108 ENOG4105C7S Dehydrogenase FORC085_4109 ENOG4105CPP Dehydrogenase, E1 component FORC085_4112 ENOG4105CKM Branched-chain carboxylic acid kinase FORC085_4113 ENOG4107RDP Dehydrogenase FORC085_4115 ENOG4108JUB Transcriptional regulator FORC085_4117 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC085_412 ENOG4105C59 p-type ATPase FORC085_4120 ENOG4107QQR Sporulation FORC085_4121 ENOG4105S1Z Stage IV sporulation protein B FORC085_4122 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FORC085_4123 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FORC085_4124 ENOG4105DX0 Hemolysin A FORC085_4126 ENOG4105CTB Polyprenyl synthetase FORC085_4129 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FORC085_413 ENOG4108IPJ Membrane FORC085_4131 ENOG4108ZSR alkaline shock protein FORC085_4132 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC085_4136 ENOG410644B Stage III sporulation protein af FORC085_4138 ENOG4105KQ4 Stage iii sporulation protein ad FORC085_4139 ENOG4108CQH stage III sporulation protein AC FORC085_4140 ENOG4105KR5 Stage iii sporulation protein FORC085_4141 ENOG4105CD2 stage iii sporulation protein aa FORC085_4146 ENOG4105DC7 peptidase M24 FORC085_4147 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FORC085_4149 ENOG4105CBJ Metal-dependent enzyme FORC085_415 ENOG4105C3F Signal peptidase i FORC085_4150 ENOG4107YBY Hydrolase FORC085_4154 ENOG4105K7K Transcriptional regulator FORC085_4157 ENOG41082GG biotin lipoate A B protein ligase FORC085_4158 ENOG4105WZW rhodanese family FORC085_4163 ENOG41080TC multidrug resistance protein FORC085_417 ENOG4107ZTW SNARE associated Golgi FORC085_4172 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC085_4175 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FORC085_4179 ENOG4105C0D helicase FORC085_420 ENOG410606W general stress protein FORC085_4204 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC085_4205 ENOG4105C3R Methionine synthase FORC085_4207 ENOG4105C28 cystathionine FORC085_4208 ENOG4105C28 cystathionine FORC085_4212 ENOG4105C5X domain protein FORC085_4214 ENOG4105DKQ ROK family FORC085_4216 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FORC085_4219 ENOG4108UTW Plays a role in the regulation of phosphate uptake FORC085_422 ENOG4105UPD Calcium Proton FORC085_4220 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FORC085_4221 ENOG4105C8U phosphate abc transporter FORC085_4222 ENOG4105C8U phosphate abc transporter FORC085_4223 ENOG4105EXS phosphate abc transporter FORC085_4224 ENOG4107RF6 penicillin-binding protein FORC085_4226 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC085_4231 ENOG4105N80 Ferric uptake regulator, Fur family FORC085_4233 ENOG4105FDK ABC transporter FORC085_4234 ENOG4108JYZ YitT family FORC085_4235 ENOG41069ZM Protein of unknown function (DUF2624) FORC085_4240 ENOG4105EGD dinuclear metal center protein, YbgI family FORC085_4243 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC085_4244 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FORC085_4251 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FORC085_4252 ENOG4105KG3 cytidine deaminase FORC085_4253 ENOG4107YR5 Diacylglycerol kinase FORC085_4254 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FORC085_4255 ENOG4105CTJ Metal Dependent Phosphohydrolase FORC085_4256 ENOG4105C9A Phoh family FORC085_4258 ENOG41068P3 sporulation protein YqfC FORC085_4260 ENOG4105KTH gatB Yqey FORC085_4262 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FORC085_4263 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FORC085_4269 ENOG4105CSA Coproporphyrinogen iii oxidase FORC085_4270 ENOG4105KVH Transcriptional regulator FORC085_4275 ENOG4105TQK DNA polymerase iii, delta' subunit FORC085_4278 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FORC085_4279 ENOG4108UK2 deaminase FORC085_4280 ENOG4105KQC Competence protein FORC085_4282 ENOG4105DXX methyltransferase FORC085_4284 ENOG4108WF2 Metal Dependent Phosphohydrolase FORC085_4286 ENOG410812S Rna-binding protein FORC085_4288 ENOG4105CQW ribosome biogenesis GTPase YqeH FORC085_4289 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FORC085_429 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC085_4292 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC085_4297 ENOG4108TVJ Nitroreductase FORC085_430 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC085_4300 ENOG4105G6Z alkaline phosphatase FORC085_4301 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FORC085_4302 ENOG4108MUZ hydrolase FORC085_4309 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC085_4311 ENOG4105MIR Phenylalanine 4-monooxygenase FORC085_4313 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC085_432 ENOG4108JUB Transcriptional regulator FORC085_4322 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC085_4323 ENOG4108V5C ABC transporter FORC085_4325 ENOG4108EKI Dehydrogenase FORC085_4326 ENOG4105C28 cystathionine FORC085_4334 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FORC085_4337 ENOG4105XYU peptidase (U32 family) FORC085_4338 ENOG4108VQJ O-methyltransferase FORC085_4339 ENOG4105HHA aminodeoxychorismate lyase FORC085_434 ENOG4108IQI permease FORC085_4343 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC085_4345 ENOG4105C02 permease FORC085_4348 ENOG41060CR FORC085_4349 ENOG4105C7H Helicase, RecD TraA family FORC085_4351 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FORC085_4352 ENOG4105C3J Cysteine desulfurase FORC085_4354 ENOG4105D1H recombination factor protein RarA FORC085_4355 ENOG4108VCI transcription factor, rsfa family FORC085_4356 ENOG4105CUZ uba thif-type nad fad binding protein FORC085_4358 ENOG4105CUT histidyl-tRNA synthetase FORC085_4361 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FORC085_4363 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FORC085_4364 ENOG41076HS cation diffusion facilitator family transporter FORC085_4365 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FORC085_4367 ENOG4105CKP Polysaccharide Biosynthesis Protein FORC085_4368 ENOG4108QG2 Membrane FORC085_4370 ENOG4105VIE preprotein translocase, subunit YajC FORC085_4373 ENOG41061AI Protein of unknown function (DUF2905) FORC085_4376 ENOG4108HUF Transporter FORC085_4382 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FORC085_4383 ENOG4108IYU L-aspartate oxidase FORC085_4386 ENOG4108RPX mosc domain containing protein FORC085_4387 ENOG4105CQC Prephenate dehydratase FORC085_4390 ENOG4105C19 ABC transporter FORC085_4391 ENOG4105EWM Histidine kinase FORC085_4393 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FORC085_4396 ENOG4105X36 (ribosomal) protein FORC085_4398 ENOG4105C03 ribonuclease FORC085_4401 ENOG4107QMS site-determining protein FORC085_4404 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FORC085_4405 ENOG4105DFF Rod shape-determining protein mreb FORC085_4409 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FORC085_4410 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FORC085_4412 ENOG41068KH stage VI sporulation protein D FORC085_4414 ENOG4105D52 delta-aminolevulinic acid dehydratase FORC085_4419 ENOG4105K56 Transcriptional regulator FORC085_4423 ENOG4108IUQ atp-dependent protease FORC085_443 ENOG4108A04 Beta-lactamase FORC085_4430 ENOG4108QCI YvbH-like oligomerisation region FORC085_4432 ENOG4105M59 Phosphodiesterase, mj0936 family FORC085_4433 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FORC085_4435 ENOG4108XJQ germination protein FORC085_4438 ENOG4108PCX Major Facilitator FORC085_4440 ENOG4105KBX Transcriptional regulator, TetR family FORC085_4442 ENOG4105PFC Transcriptional regulator FORC085_4445 ENOG4105DZC cytosine deaminase FORC085_4446 ENOG41067S9 phage shock protein C, PspC FORC085_4447 ENOG4108JCI Transcriptional regulator FORC085_4449 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FORC085_4450 ENOG4108Z40 Transcriptional regulator FORC085_4451 ENOG4105RHA ABC transporter, permease FORC085_4452 ENOG4108IUX (ABC) transporter FORC085_4453 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FORC085_4454 ENOG4105ER2 Ompa motb domain protein FORC085_4455 ENOG4105E14 MotA TolQ exbB proton channel FORC085_4456 ENOG4108VXD carboxy-peptidase FORC085_4458 ENOG4105E33 succinate dehydrogenase FORC085_446 ENOG4105CKK Glycosyl transferase, family 2 FORC085_4460 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FORC085_4462 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC085_4463 ENOG4105K63 Thioredoxin FORC085_4464 ENOG4105C10 Electron transfer flavoprotein FORC085_4465 ENOG4105BZJ Electron transfer flavoprotein FORC085_4466 ENOG41060WC Enoyl-CoA hydratase FORC085_4467 ENOG4107Z3H Transcriptional regulator, TetR family FORC085_4468 ENOG4105CEY Amp-dependent synthetase and ligase FORC085_447 ENOG4107QQG Dehydrogenase FORC085_4470 ENOG4105J76 Periplasmic binding protein FORC085_4471 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC085_448 ENOG4105C3I Nad-dependent epimerase dehydratase FORC085_4481 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC085_4484 ENOG4105DR4 Methyltransferase FORC085_4486 ENOG4105KFN sortase, SrtB family FORC085_4487 ENOG4105E0A ABC, transporter FORC085_4490 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FORC085_4492 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FORC085_4495 ENOG4105FE9 pseudouridine synthase FORC085_4498 ENOG4105DCG PHP domain protein FORC085_4501 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FORC085_4507 ENOG4105C5S asparaginyl-tRNA synthetase FORC085_4508 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FORC085_4510 ENOG4108RWN rrna methyltransferase FORC085_4516 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC085_4517 ENOG4105CW7 secretion protein, HlyD family FORC085_4518 ENOG4108JGH Tetr family transcriptional regulator FORC085_4519 ENOG4105CN9 Peptidase m42 family protein FORC085_452 ENOG4105F1A Pyruvate formate-lyase FORC085_4523 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FORC085_4524 ENOG4105C22 threonyL-tRNA synthetase FORC085_4525 ENOG4108TDW sporulation protein YtxC FORC085_4530 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC085_4532 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FORC085_4533 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FORC085_4535 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FORC085_4536 ENOG4105C2M dna polymerase I FORC085_4537 ENOG4105BZU Histidine kinase FORC085_4538 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC085_4543 ENOG4108HMX isocitrate dehydrogenase (NADP) FORC085_4544 ENOG4105BZN citrate synthase FORC085_4546 ENOG4108REF Sporulation integral membrane protein ytvi FORC085_4547 ENOG4105FS0 cytoplasmic membrane protein FORC085_4552 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC085_4553 ENOG4105C6K Malic enzyme FORC085_4554 ENOG4105C0B DNA polymerase III (alpha subunit) FORC085_4555 ENOG4105VV2 FORC085_4557 ENOG4105SFS phosphoesterase RecJ domain protein FORC085_456 ENOG4105CI2 imidazolone-5-propionate hydrolase FORC085_4562 ENOG4105E8R UPF0173 metal-dependent hydrolase FORC085_4563 ENOG4105DC7 peptidase M24 FORC085_4569 ENOG4105Z7P Acetyltransferase (GNAT) family FORC085_457 ENOG4105ECP epimerase FORC085_4570 ENOG41082W1 Cupin 2, conserved barrel domain protein FORC085_4574 ENOG4107YZX Universal stress protein FORC085_4583 ENOG4108JYZ YitT family FORC085_4587 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FORC085_4589 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FORC085_4590 ENOG4105KBJ sporulation protein ytfj FORC085_4593 ENOG4105EFZ amidohydrolase FORC085_4595 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC085_4600 ENOG4105RQF LysR family Transcriptional regulator FORC085_4602 ENOG4105U5Y Transcriptional regulator FORC085_4604 ENOG4105C28 cystathionine FORC085_4612 ENOG4108IBT Inherit from COG: transposase FORC085_4614 ENOG4108IBT Inherit from COG: transposase FORC085_4615 ENOG4108IBT Inherit from COG: transposase FORC085_4620 ENOG4108UW5 maltose o-acetyltransferase FORC085_4622 ENOG4105F1V Acetoin utilization protein FORC085_4623 ENOG4105W87 Cbs domain FORC085_4624 ENOG4105DGU Histone deacetylase FORC085_4627 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC085_4629 ENOG4107SNB ankyrin repeat protein YahD FORC085_463 ENOG41067AE Membrane-bound metal-dependent hydrolase FORC085_4630 ENOG4105EP9 oxidoreductase FORC085_4636 ENOG4105ETE Transcriptional regulator (LacI family FORC085_4637 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC085_464 ENOG4105CEN a g-specific adenine glycosylase FORC085_4641 ENOG4105C88 aminopeptidase FORC085_4648 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC085_465 ENOG4106BXE FORC085_4650 ENOG4108VDD TRNA binding domain protein FORC085_4656 ENOG4105C8F Beta-lactamase domain protein FORC085_4659 ENOG4108V15 phosphotransferase enzyme family FORC085_4660 ENOG4108IUM Glycogen debranching enzyme FORC085_4662 ENOG4107QSE Dipeptidase FORC085_4663 ENOG4105YW5 deoR family transcriptional regulator FORC085_4666 ENOG4105CBX hi0933 family FORC085_4669 ENOG4105DQ6 Transposase FORC085_4675 ENOG4108VJ1 Transcriptional regulator (CarD family FORC085_4676 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FORC085_4677 ENOG4105CSC Glucose uptake protein FORC085_4680 ENOG4108ZAF Molybdopterin FORC085_4681 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FORC085_4682 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC085_4684 ENOG4105D06 uba thif-type nad fad binding protein FORC085_4685 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC085_4689 ENOG41085GJ domain protein FORC085_4691 ENOG4105DWV Homoserine O-trans-acetylase FORC085_4695 ENOG4108B31 Spore germination protein FORC085_4702 ENOG410605W Major Facilitator FORC085_4703 ENOG4107S91 Sodium hydrogen exchanger FORC085_4704 ENOG4105NCW Trka-c domain protein FORC085_4707 ENOG4105C19 ABC transporter FORC085_471 ENOG4105BZ1 (ABC) transporter FORC085_4711 ENOG4105N5T Radical SAM Protein FORC085_4717 ENOG4105E8V Alpha Beta Hydrolase Fold protein FORC085_4718 ENOG4108Z0R Transferase FORC085_4719 ENOG4105YVM Phosphoesterase, PA-phosphatase related FORC085_472 ENOG4107NBY Membrane FORC085_4720 ENOG4105BZF Glycosyl transferase (Group 1 FORC085_4722 ENOG4105EPU Molybdenum cofactor synthesis domain protein FORC085_4724 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC085_473 ENOG4105CBC glutamate synthase FORC085_4735 ENOG4105BZU Histidine kinase FORC085_4736 ENOG4105BZU Histidine kinase FORC085_4737 ENOG4105CH6 catalase FORC085_4739 ENOG4107S9D Alpha beta hydrolase FORC085_4740 ENOG4107T7U Sulfatase FORC085_4745 ENOG4105D2X ABC transporter substrate-binding protein FORC085_4747 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FORC085_475 ENOG4108IUW ABC transporter FORC085_4760 ENOG4108V2W Carbonate dehydratase FORC085_4762 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC085_4763 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC085_4771 ENOG41087YS Phage shock protein A FORC085_4777 ENOG4105BZU Histidine kinase FORC085_4778 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC085_4783 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC085_4784 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FORC085_479 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC085_4793 ENOG4107ZTW SNARE associated Golgi FORC085_4796 ENOG4105C19 ABC transporter FORC085_4797 ENOG41086D8 Transcriptional regulator FORC085_480 ENOG4105G5W regulator Fur family FORC085_4802 ENOG41082BM Transcriptional regulator, arsr family FORC085_4810 ENOG4105C6Z Gluconate FORC085_4811 ENOG4105FDP GntR family transcriptional regulator FORC085_4815 ENOG41069H0 dihydroorotase EC 3.5.2.3 FORC085_4819 ENOG4105DTQ mandelate racemase muconate lactonizing FORC085_4820 ENOG4105CEY Amp-dependent synthetase and ligase FORC085_4821 ENOG4108IPT Naphthoate synthase FORC085_4822 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FORC085_4823 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FORC085_4824 ENOG4105E4F Isochorismate synthase FORC085_4826 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC085_4828 ENOG4105VEQ Cold shock protein FORC085_4836 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FORC085_4839 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC085_484 ENOG4105CDY transcriptional regulatory protein FORC085_4840 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC085_4841 ENOG4105KT7 mgtC SapB transporter FORC085_4843 ENOG4107PBV potassium channel FORC085_4845 ENOG4105WG9 Conserved Protein FORC085_4847 ENOG4105CHM Aminotransferase FORC085_4848 ENOG4108ZB6 transcriptional regulator AsnC family FORC085_4849 ENOG4105C5I Dehydrogenase FORC085_4850 ENOG4108MUZ hydrolase FORC085_4852 ENOG4105C87 Aminotransferase class I and II FORC085_4855 ENOG4105Y38 Kinase-associated protein B FORC085_4857 ENOG4107R3E Citrate transporter FORC085_486 ENOG4108JQC penicillin-binding protein 1A FORC085_4860 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FORC085_4861 ENOG4105KA0 thioesterase Superfamily protein FORC085_4864 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC085_4869 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FORC085_487 ENOG4108R9S DSBA oxidoreductase FORC085_4870 ENOG4106YN8 Prenyltransferase FORC085_4872 ENOG41069ER domain protein FORC085_4875 ENOG4105CEP NADH dehydrogenase FORC085_488 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FORC085_4881 ENOG4105EWC Purine nucleoside phosphorylase FORC085_4886 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FORC085_4892 ENOG4108JJA ABC, transporter FORC085_4893 ENOG4105C4B ABC transporter, permease FORC085_4894 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FORC085_490 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FORC085_4903 ENOG41083MR nifu domain-containing protein FORC085_4906 ENOG4108W5N phosphatidylglycerophosphatase a FORC085_491 ENOG4105BZU Histidine kinase FORC085_4910 ENOG4105DAX Pfam:DUF2983 FORC085_4913 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC085_4914 ENOG4105D4U had-superfamily hydrolase, subfamily iia FORC085_4917 ENOG4105CBT Fructose-1,6-bisphosphatase FORC085_4921 ENOG4105MMD transcriptional regulator FORC085_4922 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FORC085_4923 ENOG4107TXC Transcriptional regulator FORC085_4924 ENOG41090T1 Membrane FORC085_4929 ENOG4105FAA peptidase M23 FORC085_493 ENOG4105CYN Serine protein kinase FORC085_4930 ENOG4108YTE sporulation protein YunB FORC085_4931 ENOG4105KZD Domain of unknown function (DUF1805) FORC085_4932 ENOG4107R8B 5'-nucleotidase FORC085_4933 ENOG4105DIW FeS assembly protein SUFB FORC085_4934 ENOG4108UNV SUF system FeS assembly protein, NifU family FORC085_4935 ENOG4105C9B Cysteine desulfurase FORC085_4936 ENOG4105JRK feS assembly protein SufD FORC085_4937 ENOG4105C3K feS assembly ATPase SufC FORC085_4938 ENOG4105D01 (LipO)protein FORC085_4939 ENOG4105D01 (LipO)protein FORC085_4940 ENOG4108UMI ABC transporter, permease FORC085_4941 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC085_4947 ENOG41080E8 Transcriptional regulator, Spx MgsR family FORC085_4951 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC085_4959 ENOG4108W8B Beta-lactamase domain protein FORC085_4960 ENOG4105C1G acyl-Coa dehydrogenase FORC085_4962 ENOG4105CHU acetyl-coa acetyltransferase FORC085_4965 ENOG4105DZ1 carboxypeptidase FORC085_4969 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC085_4972 ENOG4108SUT Major Facilitator Superfamily FORC085_4973 ENOG4107R7I amino acid FORC085_4976 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC085_4978 ENOG4107AYK membrAne FORC085_4986 ENOG4107ZTW SNARE associated Golgi FORC085_4988 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC085_4989 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC085_4990 ENOG4105BZU Histidine kinase FORC085_4996 ENOG4105C8Q Methyl-accepting chemotaxis FORC085_4997 ENOG4105VG1 fes assembly suf system protein FORC085_4998 ENOG4105D4Y metalloprotease FORC085_4999 ENOG4105C2I pirin domain protein FORC085_5002 ENOG4107T5V SNARE associated Golgi FORC085_5003 ENOG4107S91 Sodium hydrogen exchanger FORC085_5004 ENOG4105NCW Trka-c domain protein FORC085_5007 ENOG4108RMU ferritin dps family protein FORC085_5010 ENOG4108URH decarboxylase FORC085_5012 ENOG41090A1 ferritin FORC085_5014 ENOG4105D9N nucleoside FORC085_5015 ENOG4105D9N nucleoside FORC085_5019 ENOG4108RYK Nad-dependent epimerase dehydratase FORC085_5022 ENOG4105CV8 reductase FORC085_5023 ENOG4105F27 Major Facilitator FORC085_5024 ENOG4105KVH Transcriptional regulator FORC085_5027 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FORC085_5028 ENOG4105D4A Cell wall formation (By similarity) FORC085_5032 ENOG4105WMR Protein CrcB homolog FORC085_5033 ENOG4105WMR Protein CrcB homolog FORC085_5037 ENOG4105C5H ABC transporter FORC085_5038 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC085_5039 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FORC085_5041 ENOG4108W2Y isochorismatase FORC085_5045 ENOG4108V2W Carbonate dehydratase FORC085_5046 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FORC085_5050 ENOG4108IPW abc transporter atp-binding protein FORC085_5051 ENOG4105CM4 permease protein FORC085_5057 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FORC085_5059 ENOG4105XZU Preprotein translocase, subunit SecG FORC085_5060 ENOG41067MG lrgb family FORC085_5070 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC085_5071 ENOG4105RHA ABC transporter, permease FORC085_5072 ENOG4108IUX (ABC) transporter FORC085_5074 ENOG4105BZU Histidine kinase FORC085_5075 ENOG4108W5X Transcriptional Regulator, LuxR family FORC085_5078 ENOG41090VF Stage v sporulation protein ac FORC085_5079 ENOG4105CZ3 stage V sporulation protein ad FORC085_5082 ENOG4108QY0 Membrane FORC085_5083 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FORC085_5084 ENOG4105KRI phosphocarrier protein (HPr FORC085_5086 ENOG4105CHW UPF0052 protein FORC085_5087 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FORC085_5088 ENOG4108Z4K mutator MutT protein FORC085_5090 ENOG4105C3M thioredoxin reductase FORC085_5092 ENOG4108S4C acetyltransferase FORC085_5096 ENOG41086DT Membrane protein of unknown function FORC085_5098 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC085_5099 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FORC085_5102 ENOG4107TXC Transcriptional regulator FORC085_5107 ENOG4105HMI Membrane FORC085_5108 ENOG4105DUM transcriptional regulator, lysR family FORC085_5110 ENOG4108WS4 fmn reductase FORC085_5113 ENOG4105BZ1 (ABC) transporter FORC085_5115 ENOG4105CN1 protease FORC085_5116 ENOG4105CRP Part of the ABC transporter FtsEX involved in FORC085_5117 ENOG4105CAK Cell division ATP-binding protein ftsE FORC085_5122 ENOG4105MS2 ribosomal subunit Interface protein FORC085_5124 ENOG4105VEQ Cold shock protein FORC085_5125 ENOG41081UC Inherit from COG: Competence protein FORC085_5129 ENOG4105KVH Transcriptional regulator FORC085_5132 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FORC085_5133 ENOG4108KGH TRANSCRIPTIONal FORC085_5134 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FORC085_5135 ENOG4105C6Y Udp-glucose 6-dehydrogenase FORC085_5136 ENOG4105ESV Glycosyl transferase, family 4 FORC085_5138 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FORC085_5142 ENOG4105F8D glycoside hydrolase family 4 FORC085_5143 ENOG4105VCP PTS System FORC085_5144 ENOG4105CK1 PTS System FORC085_5146 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FORC085_5147 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC085_5148 ENOG4105VCP PTS System FORC085_5150 ENOG4105VZJ PTS System FORC085_5154 ENOG4105ECB domain protein FORC085_5155 ENOG4107RSM transcriptional regulator FORC085_5165 ENOG4105DAA L-lactate FORC085_5167 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FORC085_5169 ENOG4105E0M Sulfatase FORC085_5177 ENOG4107R8N Glycosyl transferase, family 2 FORC085_5179 ENOG4105C94 Transporter FORC085_5180 ENOG41069ER domain protein FORC085_5185 ENOG4105KBK Zinc finger, swim domain protein FORC085_5186 ENOG4105C0D helicase FORC085_5192 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC085_5194 ENOG4107RBB ABC transporter, permease FORC085_5195 ENOG4105C19 ABC transporter FORC085_5199 ENOG4105CXY transporter FORC085_5202 ENOG4105BZU Histidine kinase FORC085_5203 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC085_5204 ENOG4105CMR udp-glucose 4-epimerase FORC085_5206 ENOG4108KGH TRANSCRIPTIONal FORC085_5208 ENOG4105K64 Glycosyl transferase, family 2 FORC085_521 ENOG4105C94 Transporter FORC085_5211 ENOG4107T8Q Glycosyl transferase (Group 1 FORC085_5213 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FORC085_5214 ENOG4105CPF Cell wall formation (By similarity) FORC085_5215 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FORC085_5217 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC085_5218 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FORC085_5219 ENOG4107YJ4 chain length determinant protein FORC085_5220 ENOG4105HTX biosynthesis protein FORC085_5221 ENOG4107YJ4 chain length determinant protein FORC085_5224 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FORC085_5226 ENOG4105FRN stage II sporulation protein FORC085_5229 ENOG4105DY9 regulatoR FORC085_5233 ENOG4106778 Protein of unknown function (DUF1146) FORC085_5234 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC085_5235 ENOG4105C8S subunit m FORC085_5236 ENOG4105D65 subunit l FORC085_524 ENOG4105DZ6 Band 7 protein FORC085_5241 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC085_5242 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC085_5244 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC085_5245 ENOG4105BZU Histidine kinase FORC085_5256 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FORC085_5257 ENOG41062M3 atp synthase FORC085_526 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FORC085_5261 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FORC085_5262 ENOG4108UIC UPF0340 protein FORC085_5263 ENOG4108YZG isomerase FORC085_5266 ENOG4108VGI doxx family FORC085_5267 ENOG4107XC4 flavin reductase domain protein, FMN-binding FORC085_527 ENOG4108V9W transcriptional regulatory protein FORC085_5272 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC085_5274 ENOG4108ZXQ stage ii sporulation protein r FORC085_5275 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FORC085_5276 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FORC085_5277 ENOG4107104 thymidine kinase FORC085_5279 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FORC085_528 ENOG4105D4T Citrate transporter FORC085_5280 ENOG4105CBT Fructose-1,6-bisphosphatase FORC085_5282 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FORC085_5286 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FORC085_5289 ENOG4105C1G acyl-Coa dehydrogenase FORC085_5290 ENOG4105C1G acyl-Coa dehydrogenase FORC085_5291 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FORC085_5293 ENOG4105DF6 Fe-S oxidoreductase FORC085_5296 ENOG4105BZU Histidine kinase FORC085_5299 ENOG4105D4Y metalloprotease FORC085_5301 ENOG4105BZU Histidine kinase FORC085_5302 ENOG4105KCT ABC transporter FORC085_5303 ENOG4108M15 ABC transporter FORC085_5304 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FORC085_5306 ENOG4105IIU Aminopeptidase FORC085_5310 ENOG4105DU6 RNA polymerase FORC085_5312 ENOG410684U Domain of unknown function (DUF1934) FORC085_5317 ENOG4105CYW agmatinase FORC085_5319 ENOG4105DXB Major Facilitator superfamily FORC085_5320 ENOG4107SWG transcriptional regulator MERR family FORC085_5322 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC085_5323 ENOG4105BZ4 penicillin-binding protein FORC085_5324 ENOG4108XFG YwhD family FORC085_5325 ENOG4108Z4T Peptidase M50 FORC085_5326 ENOG41069HH 4-oxalocrotonate tautomerase FORC085_5327 ENOG4105DCI Phosphohydrolase FORC085_5328 ENOG4108MES Periplasmic binding protein FORC085_5329 ENOG4105E0A ABC, transporter FORC085_533 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC085_5330 ENOG4105EHG Permease protein FORC085_5331 ENOG4105DQ5 transport system permease protein FORC085_5333 ENOG4108VCI transcription factor, rsfa family FORC085_5334 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FORC085_5335 ENOG4108IJ2 phosphate acetyltransferase FORC085_5336 ENOG4107UEZ chlorite dismutase FORC085_5338 ENOG4108VKI Cell wall hydrolase FORC085_534 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC085_5342 ENOG4107SVH Potassium channel protein FORC085_5344 ENOG410667J hydrolase FORC085_5345 ENOG4105VCH membrane FORC085_5347 ENOG4108TU7 Inherit from COG: (ABC) transporter FORC085_5348 ENOG4105CJ1 ABC, transporter FORC085_5349 ENOG41090WU lipolytic protein G-D-S-L family FORC085_535 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FORC085_5352 ENOG4105D6E homoserine dehydrogenase FORC085_5357 ENOG4108Y4K DNA-binding transcriptional activator FORC085_5359 ENOG4105WH1 Two component transcriptional regulator luxr family FORC085_536 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FORC085_5360 ENOG4105BZU Histidine kinase FORC085_5361 ENOG4105DWF phosphomethylpyrimidine kinase FORC085_5362 ENOG4105BZU Histidine kinase FORC085_5363 ENOG4105VCD cytoplasmic protein FORC085_5364 ENOG4105D22 carbon starvation protein FORC085_5365 ENOG4105DY9 regulatoR FORC085_5366 ENOG41079KZ Major Facilitator Superfamily FORC085_5369 ENOG4105CG5 Glycosyl transferase (Group 1 FORC085_537 ENOG4105BZ7 extracellular solute-binding protein family 1 FORC085_5371 ENOG4105EN6 Membrane FORC085_5372 ENOG4106YBV Methyl-accepting chemotaxis FORC085_5375 ENOG4108S4H thioesterase Superfamily protein FORC085_5376 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FORC085_5378 ENOG4105K64 Glycosyl transferase, family 2 FORC085_5380 ENOG4105EJV Membrane FORC085_5381 ENOG4105CKK Glycosyl transferase, family 2 FORC085_5382 ENOG4105C5H ABC transporter FORC085_5383 ENOG41067SE Tetr family transcriptional regulator FORC085_5385 ENOG4105E0X reductase FORC085_5386 ENOG4106F5Q Membrane FORC085_5389 ENOG4108NEV two component transcriptional regulator, LytTR family FORC085_539 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FORC085_5390 ENOG4108HRK Histidine kinase FORC085_5391 ENOG4107RGD Major Facilitator superfamily FORC085_5394 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC085_5396 ENOG4105IW1 AmiS UreI transporter FORC085_5397 ENOG4105CMR udp-glucose 4-epimerase FORC085_5398 ENOG4108UT2 hemolysin iii FORC085_540 ENOG4108STX response regulator FORC085_5400 ENOG4105C1J atp-dependent rna helicase FORC085_5401 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FORC085_5402 ENOG4105DPN Oligoendopeptidase f FORC085_5404 ENOG4105BZU Histidine kinase FORC085_5405 ENOG4107Y5K Resolvase FORC085_5407 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC085_541 ENOG41062D9 Histidine kinase FORC085_5418 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FORC085_5419 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FORC085_5421 ENOG4105C0H protease FORC085_5422 ENOG4105Q2H domain protein FORC085_5425 ENOG4105BZU Histidine kinase FORC085_5426 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC085_5427 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FORC085_5428 ENOG4105CDU Replicative dna helicase FORC085_5430 ENOG4105BZR domain protein FORC085_5431 ENOG4108XMW Membrane FORC085_5433 ENOG4108UUM single-stranded DNA-binding protein FORC085_5435 ENOG4105C3G gtp-binding protein FORC085_5436 ENOG4105VDK protein, conserved in bacteria FORC085_5437 ENOG4105D8X mechanosensitive ion channel FORC085_5438 ENOG4108ZDA Sporulation protein YyaC FORC085_5439 ENOG4105FA0 parb-like partition protein FORC085_5440 ENOG4107QJE Chromosome Partitioning Protein FORC085_5443 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FORC085_5444 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FORC085_5446 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC085_547 ENOG4108MRH transcriptional regulatory protein FORC085_549 ENOG4105C6K Malic enzyme FORC085_552 ENOG4108UZ3 Transporter FORC085_553 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC085_555 ENOG4105BZU Histidine kinase FORC085_559 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FORC085_560 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC085_561 ENOG4108JB9 formate dehydrogenase FORC085_564 ENOG4105DQ6 Transposase FORC085_567 ENOG4105CUB amino acid FORC085_570 ENOG4105C59 p-type ATPase FORC085_571 ENOG4105DAP Nicotinate phosphoribosyltransferase FORC085_578 ENOG41073R8 VanW family FORC085_579 ENOG4108KGH TRANSCRIPTIONal FORC085_580 ENOG4105D9N nucleoside FORC085_581 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FORC085_582 ENOG4105C37 (CBS) domain FORC085_583 ENOG4108IJ0 Aspartate ammonia-lyase FORC085_584 ENOG4105DAA L-lactate FORC085_587 ENOG4105DUX Transporter FORC085_588 ENOG4108MES Periplasmic binding protein FORC085_589 ENOG4105DQ5 transport system permease protein FORC085_590 ENOG4108IHU transport system permease protein FORC085_591 ENOG4105E0A ABC, transporter FORC085_592 ENOG4105DMQ Methyltransferase FORC085_593 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FORC085_594 ENOG4105EXW epimerase dehydratase FORC085_596 ENOG4107T89 von Willebrand factor, type A FORC085_597 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FORC085_598 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC085_600 ENOG4105BZU Histidine kinase FORC085_601 ENOG4105D5Q Arginine ornithine antiporter FORC085_602 ENOG4107414 GntR family transcriptional regulator FORC085_603 ENOG4105C5Y PTS System FORC085_604 ENOG4105CG3 alpha amylase, catalytic region FORC085_607 ENOG4105E1K spore germination protein FORC085_608 ENOG4105CRN Aminoglycoside phosphotransferase FORC085_609 ENOG4105BZG amino acid carrier protein FORC085_611 ENOG4105CDA abc transporter atp-binding protein FORC085_612 ENOG4105CT1 (ABC) transporter FORC085_613 ENOG4105EAD ABC transporter FORC085_614 ENOG4105DRP amino acid AbC transporter FORC085_615 ENOG4108IQI permease FORC085_618 ENOG4105D29 Helix-turn-helix type 11 domain protein FORC085_619 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC085_620 ENOG4105BZU Histidine kinase FORC085_625 ENOG4105CHH sulfate transporter FORC085_626 ENOG41068KF Universal stress protein FORC085_628 ENOG4105CXY transporter FORC085_630 ENOG41067TZ transcriptional regulator, MarR family FORC085_631 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC085_632 ENOG4105ETE Transcriptional regulator (LacI family FORC085_633 ENOG4108RVA ribokinase FORC085_635 ENOG4105C2J ABC transporter FORC085_636 ENOG4105CNN ABC, transporter FORC085_637 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FORC085_638 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC085_644 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FORC085_650 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC085_651 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC085_652 ENOG41069ER domain protein FORC085_653 ENOG4105VZ8 Transcriptional regulator FORC085_654 ENOG4107D63 FORC085_657 ENOG4105DUX Transporter FORC085_662 ENOG4105C85 amino acid FORC085_663 ENOG4105C7N Xanthine uracil vitamin C permease FORC085_665 ENOG4105D7V transposase FORC085_668 ENOG4105MA6 gCN5-related N-acetyltransferase FORC085_672 ENOG4105CCU oxidase (Subunit III) FORC085_673 ENOG4105BZ9 Cytochrome C oxidase, subunit I FORC085_674 ENOG4105E2S oxidase) subunit II FORC085_678 ENOG4106CAD Protein of unknown function (DUF3311) FORC085_679 ENOG4105E1V na solute symporter FORC085_682 ENOG4108NHD germination protein FORC085_684 ENOG4105CE1 Ferrous iron transport protein b FORC085_685 ENOG4105CE1 Ferrous iron transport protein b FORC085_686 ENOG4105CE1 Ferrous iron transport protein b FORC085_687 ENOG4105CVA phosphate FORC085_688 ENOG4105C8U phosphate abc transporter FORC085_689 ENOG4105E2Z phosphate ABC transporter (Permease FORC085_691 ENOG41080XQ Signal transduction protein with cbs domains FORC085_695 ENOG4105ETU transcriptional activator (TenA FORC085_697 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC085_699 ENOG4108VEU Thiamine monophosphate synthase FORC085_700 ENOG41080HI glycine oxidase FORC085_703 ENOG4105D06 uba thif-type nad fad binding protein FORC085_704 ENOG4105DWF phosphomethylpyrimidine kinase FORC085_715 ENOG4108INS Transcriptional regulator FORC085_717 ENOG4105C7N Xanthine uracil vitamin C permease FORC085_719 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC085_723 ENOG4105C5Y PTS System FORC085_726 ENOG4105K63 Thioredoxin FORC085_730 ENOG4108B31 Spore germination protein FORC085_734 ENOG4107Y03 Nitroreductase FORC085_735 ENOG4105ED1 spovr family FORC085_737 ENOG4108TCS Glutamyl endopeptidase FORC085_742 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FORC085_743 ENOG4105XTG Pfam:DUF156 FORC085_744 ENOG4105VFE sira family FORC085_745 ENOG4107TPS domain protein FORC085_746 ENOG4105VFE sira family FORC085_747 ENOG4105VFE sira family FORC085_748 ENOG41085GJ domain protein FORC085_749 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FORC085_750 ENOG41087NI Sulfite exporter TauE/SafE FORC085_752 ENOG4108KGH TRANSCRIPTIONal FORC085_757 ENOG4105EMD TRANSCRIPTIONal FORC085_758 ENOG4105VCP PTS System FORC085_759 ENOG4105VZJ PTS System FORC085_764 ENOG41069ER domain protein FORC085_765 ENOG4107RBB ABC transporter, permease FORC085_766 ENOG4105C19 ABC transporter FORC085_772 ENOG4105WEF catalase FORC085_779 ENOG4107T5V SNARE associated Golgi FORC085_786 ENOG4105CUB amino acid FORC085_787 ENOG4107RWR Sodium hydrogen exchanger FORC085_789 ENOG4106KNT transcriptional regulator FORC085_797 ENOG4108YXU transcriptional regulator AsnC family FORC085_799 ENOG4108IXY short-chain dehydrogenase reductase FORC085_802 ENOG4105KPY Small multidrug resistance protein FORC085_809 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC085_810 ENOG4105E5W Transporter FORC085_813 ENOG4107RKG DJ-1/PfpI family FORC085_814 ENOG4105CH6 catalase FORC085_816 ENOG4105D5Q Arginine ornithine antiporter FORC085_817 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FORC085_819 ENOG4105C26 Dehydrogenase FORC085_820 ENOG4105BZ1 (ABC) transporter FORC085_821 ENOG4105BZ1 (ABC) transporter FORC085_823 ENOG4105DRP amino acid AbC transporter FORC085_824 ENOG4105CDA abc transporter atp-binding protein FORC085_827 ENOG410839P FORC085_835 ENOG4107FQX Alpha-acetolactate decarboxylase FORC085_839 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC085_840 ENOG4105D4P Coproporphyrinogen iii oxidase FORC085_841 ENOG4105CEY Amp-dependent synthetase and ligase FORC085_844 ENOG4105CHH sulfate transporter FORC085_849 ENOG4105CGU Enoyl-CoA hydratase FORC085_853 ENOG4105DER m42 family FORC085_857 ENOG4105CTU Proline racemase FORC085_858 ENOG4105CIF Ornithine Cyclodeaminase FORC085_861 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC085_862 ENOG4105C3U ABC transporter FORC085_863 ENOG4108JQ7 (ABC) transporter FORC085_872 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FORC085_880 ENOG4108IBT Inherit from COG: transposase FORC085_905 ENOG4105CSH Transporter FORC085_907 ENOG4108MRH transcriptional regulatory protein FORC085_921 ENOG4105CDU Replicative dna helicase FORC085_932 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC085_936 ENOG4105D9U N-acetyltransferase FORC085_941 ENOG4105F6J Alpha beta hydrolase fold FORC085_951 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC085_954 ENOG4105CMT Dihydroxyacetone kinase FORC085_956 ENOG4105CMT Dihydroxyacetone kinase FORC085_984 ENOG4105WN5 stage II sporulation protein FORC085_986 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC085_988 ENOG4108MJI response regulator FORC085_989 ENOG4105BZU Histidine kinase FORC085_990 ENOG4105BZU Histidine kinase FORC085_995 ENOG4105K8R UPF0145 protein FORC085_999 ENOG4107QHE Choloylglycine hydrolase FORC085_t0098 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation