locus-tag class description BG11_1 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BG11_10 ENOG410890F Dynamin family BG11_101 ENOG4107RSM transcriptional regulator BG11_1010 ENOG4105FDR Membrane BG11_1012 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BG11_1017 ENOG4108IUM Glycogen debranching enzyme BG11_1020 ENOG4105DY8 decarboxylase BG11_1025 ENOG4105U0R haloacid dehalogenase-like hydrolase BG11_103 ENOG4105CJ1 ABC, transporter BG11_1030 ENOG4107VFR oxidoreductase BG11_1038 ENOG4105PKS Excinuclease abc c subunit domain protein BG11_1045 ENOG4105KWG Pfam:DUF1696 BG11_1046 ENOG4108NRW Phospholipase, patatin family BG11_105 ENOG4105CH2 amidohydrolase BG11_1050 ENOG4108XI2 Domain of unknown function (DUF1963) BG11_1058 ENOG4108Z4K mutator MutT protein BG11_1059 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BG11_1060 ENOG4105E09 nadh pyrophosphatase BG11_1063 ENOG4105FCD Major Facilitator BG11_107 ENOG4107QIV Cytochrome c biogenesis protein BG11_1071 ENOG4107Y9U Membrane BG11_1075 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BG11_1079 ENOG4107Y80 Major Facilitator superfamily BG11_1084 ENOG4108V4B ThiJ pfpI BG11_1090 ENOG4105FQP Beta-lactamase BG11_1092 ENOG4105CJN penicillin-binding protein BG11_1093 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BG11_1094 ENOG4105CB2 alcohol dehydrogenase BG11_1097 ENOG4108HGU Histidine kinase BG11_11 ENOG4105E0M Sulfatase BG11_1104 ENOG4107RF6 penicillin-binding protein BG11_1105 ENOG4105BZU Histidine kinase BG11_1106 ENOG410667J hydrolase BG11_1122 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BG11_114 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BG11_1154 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BG11_1174 ENOG4105VTR Integrase BG11_1182 ENOG4105ETU transcriptional activator (TenA BG11_1199 ENOG4105DK7 lysyl-tRNA synthetase BG11_12 ENOG4107R6R udp-galactopyranose mutase BG11_120 ENOG4108903 Formimidoylglutamase BG11_1201 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BG11_1205 ENOG4105CPQ Dehydrogenase BG11_121 ENOG4108VJ1 Transcriptional regulator (CarD family BG11_1212 ENOG4105CUV Homoserine Kinase BG11_1216 ENOG4107Y80 Major Facilitator superfamily BG11_1218 ENOG4105FQP Beta-lactamase BG11_122 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BG11_1228 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BG11_123 ENOG4105CBC glutamate synthase BG11_1230 ENOG4105T9C HD domain BG11_1233 ENOG4105DZ1 carboxypeptidase BG11_1236 ENOG4105DBI uridine monophosphokinase BG11_1237 ENOG4105WCN acetyltransferase BG11_1239 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BG11_124 ENOG4105CK7 Sodium proline symporter BG11_1240 ENOG4107QX3 carboxylase BG11_1241 ENOG4105E39 Enoyl-CoA hydratase BG11_1242 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BG11_1243 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BG11_1244 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BG11_1245 ENOG4105C1G acyl-Coa dehydrogenase BG11_1248 ENOG4107Z3H Transcriptional regulator, TetR family BG11_125 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BG11_1250 ENOG4105CJ1 ABC, transporter BG11_1253 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BG11_1256 ENOG4105BZU Histidine kinase BG11_1257 ENOG4105C5H ABC transporter BG11_1258 ENOG41067SE Tetr family transcriptional regulator BG11_1259 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity BG11_126 ENOG4105FBA Phospholipase Carboxylesterase BG11_1262 ENOG4108VXD carboxy-peptidase BG11_1265 ENOG4105VZ8 Transcriptional regulator BG11_1268 ENOG4105CGH 5'-nucleotidase BG11_127 ENOG4105BZU Histidine kinase BG11_1271 ENOG4105DH8 myo-inositol catabolism BG11_1272 ENOG4105D2N Aldolase BG11_1277 ENOG4105CK5 oxidoreductase BG11_1278 ENOG4105IE8 Alpha-ketoglutarate permease BG11_1279 ENOG4105ETE Transcriptional regulator (LacI family BG11_1280 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BG11_1282 ENOG4107RF6 penicillin-binding protein BG11_1283 ENOG4107RF6 penicillin-binding protein BG11_1288 ENOG4105CIN aminoacyl-histidine dipeptidase BG11_129 ENOG4107AYK membrAne BG11_1295 ENOG41090HR transcriptional regulator BG11_1296 ENOG4107RA9 decarboxylase BG11_1297 ENOG4108I0C methyltransferase BG11_1299 ENOG41088CC tellurite resistance protein tehB BG11_13 ENOG4105F0V Cell wall hydrolase BG11_1303 ENOG4108RZE Tetr family transcriptional regulator BG11_1306 ENOG4105C1J atp-dependent rna helicase BG11_1309 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BG11_1314 ENOG4107STF Involved in phosphonate degradation (By similarity) BG11_1316 ENOG4105RD7 BadF BadG BcrA BcrD BG11_1321 ENOG4105F32 YngK protein BG11_1326 ENOG4108KPJ rna polymerase sigma factor BG11_1329 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BG11_1336 ENOG4108JCI Transcriptional regulator BG11_1340 ENOG4105BZ1 (ABC) transporter BG11_1341 ENOG4105BZ1 (ABC) transporter BG11_1344 ENOG4108RPX mosc domain containing protein BG11_1345 ENOG4105DND Transcriptional regulator BG11_1348 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BG11_1349 ENOG4107V2S Transcriptional regulator BG11_1356 ENOG410667J hydrolase BG11_1360 ENOG4105VEQ Cold shock protein BG11_1362 ENOG41068WN BG11_1364 ENOG4105C1Q protoporphyrinogen oxidase BG11_1370 ENOG4105WCN acetyltransferase BG11_1375 ENOG4105EYF MMPL domain protein BG11_1377 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BG11_1380 ENOG41081I9 integral membrane protein BG11_1384 ENOG4108D32 Methyltransferase BG11_1388 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BG11_139 ENOG4105CEY Amp-dependent synthetase and ligase BG11_1390 ENOG4105C19 ABC transporter BG11_1391 ENOG4105C22 threonyL-tRNA synthetase BG11_1392 ENOG4105FE9 pseudouridine synthase BG11_1396 ENOG4105BZG amino acid carrier protein BG11_140 ENOG4107ZYJ bioY protein BG11_1400 ENOG4105K70 DNA-binding protein BG11_1403 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG11_1404 ENOG4105WQT MbtH domain protein BG11_1405 ENOG4105CEY Amp-dependent synthetase and ligase BG11_1406 ENOG4105WQI isochorismatase BG11_1407 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BG11_1408 ENOG4105E4F Isochorismate synthase BG11_1409 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BG11_141 ENOG4107F3J Amp-dependent synthetase and ligase BG11_1410 ENOG4105FCD Major Facilitator BG11_1414 ENOG4105EYH Exonuclease BG11_1415 ENOG4107RFY SbcCD D subunit BG11_1418 ENOG4105E39 Enoyl-CoA hydratase BG11_1419 ENOG4105N14 lysine exporter protein LysE YggA BG11_1421 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BG11_1422 ENOG4105C1G acyl-Coa dehydrogenase BG11_1423 ENOG4105CR4 methylisocitrate lyase BG11_1424 ENOG4105DXD 2-methylcitrate dehydratase BG11_1426 ENOG4105W8X HesB YadR YfhF-family protein BG11_1427 ENOG4105DP8 Major facilitator superfamily MFS_1 BG11_1428 ENOG4105BZ4 penicillin-binding protein BG11_1436 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BG11_145 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BG11_1456 ENOG4108IBT Inherit from COG: transposase BG11_1458 ENOG4105SZ6 Thioredoxin BG11_1459 ENOG410841Q phosphoesterase PA-phosphatase related protein BG11_1461 ENOG4108N23 SpoOM-related protein BG11_1469 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BG11_147 ENOG4105E5W Transporter BG11_1470 ENOG4108JUB Transcriptional regulator BG11_1471 ENOG4108TSC N-acetyltransferase BG11_1472 ENOG4107S4Y M20 DapE family protein YgeY BG11_1475 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BG11_1480 ENOG4105C37 (CBS) domain BG11_1487 ENOG4105E90 ABC transporter BG11_1488 ENOG4108IJ8 ABC transporter BG11_1494 ENOG4105CMG Carbohydrate kinase BG11_1495 ENOG4105CMG Carbohydrate kinase BG11_1501 ENOG4106KNT transcriptional regulator BG11_1503 ENOG4105WH1 Two component transcriptional regulator luxr family BG11_1504 ENOG4105BZU Histidine kinase BG11_1505 ENOG4105D8X mechanosensitive ion channel BG11_1506 ENOG4107Y70 Heat shock protein BG11_1512 ENOG4105F0I Aminotransferase BG11_1513 ENOG4108MES Periplasmic binding protein BG11_1517 ENOG4105CAQ asparagine synthetase BG11_1518 ENOG4107Y70 Heat shock protein BG11_1519 ENOG4108KF3 Electron transport protein SCO1 SenC BG11_1520 ENOG4105E8R UPF0173 metal-dependent hydrolase BG11_1521 ENOG4108RCR degv family BG11_1523 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BG11_1525 ENOG4108UT2 hemolysin iii BG11_1526 ENOG4105E9Q Acyl-transferase BG11_1528 ENOG4107RVG penicillin-binding protein BG11_153 ENOG4108I0Z Aconitate hydratase BG11_1531 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BG11_1534 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BG11_1539 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BG11_154 ENOG4108JJA ABC, transporter BG11_1540 ENOG4105KD7 acetyltransferase BG11_1544 ENOG4105CY2 Citrate transporter BG11_1545 ENOG4107XGZ Hydrolase BG11_1549 ENOG4105C8J )-transporter BG11_1552 ENOG41062D9 Histidine kinase BG11_1553 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG11_1554 ENOG4107QPK )-transporter BG11_1555 ENOG4105BZW Glycerate kinase BG11_156 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BG11_1566 ENOG4105EC2 ftsk spoIIIe BG11_157 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BG11_1570 ENOG4105C5S asparaginyl-tRNA synthetase BG11_1571 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BG11_1574 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BG11_1578 ENOG4105C75 arginyL-tRNA synthetase BG11_1579 ENOG4105EKQ RNA-directed DNA polymerase BG11_1584 ENOG4105EKQ RNA-directed DNA polymerase BG11_1585 ENOG4108UUM single-stranded DNA-binding protein BG11_1588 ENOG4105C5H ABC transporter BG11_1593 ENOG4105MCT stage V sporulation protein S BG11_1600 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BG11_1601 ENOG4108IFG nitrite reductase, (NAD(P)H) BG11_1602 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BG11_1603 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BG11_1604 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BG11_1605 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BG11_1609 ENOG4108ZAF Molybdopterin BG11_1610 ENOG4105CVM Molybdenum cofactor synthesis domain protein BG11_1611 ENOG4105D06 uba thif-type nad fad binding protein BG11_1612 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BG11_1613 ENOG4107V6Q Cyclic nucleotide-binding domain BG11_1616 ENOG4105D3W isochorismatase BG11_1617 ENOG4108X3M OsmC Ohr family protein BG11_1618 ENOG4106HZJ BG11_1619 ENOG4107QN2 dihydrolipoyl dehydrogenase BG11_1620 ENOG4105K63 Thioredoxin BG11_1621 ENOG4108Z40 Transcriptional regulator BG11_1624 ENOG4105R3A Nitrate reductase BG11_1625 ENOG4108IUE nitrate reductase beta subunit BG11_1627 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BG11_163 ENOG4105W8X HesB YadR YfhF-family protein BG11_1630 ENOG4108V06 Glutathione peroxidase BG11_1634 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BG11_1636 ENOG4105EMN RNA polymerase sigma factor BG11_1637 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BG11_1639 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BG11_164 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BG11_1640 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BG11_1644 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BG11_1649 ENOG4105KBJ sporulation protein ytfj BG11_165 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BG11_1651 ENOG4105EKQ RNA-directed DNA polymerase BG11_1663 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BG11_1669 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BG11_167 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG11_1670 ENOG4108JYZ YitT family BG11_1671 ENOG41087PP glycosyltransferase MGT family BG11_1674 ENOG4107RBS Methyltransferase BG11_1675 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BG11_1677 ENOG4108X4Q Hydrolase BG11_168 ENOG4105C0H protease BG11_1682 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BG11_1684 ENOG4108VXD carboxy-peptidase BG11_1686 ENOG4108ZRV stage ii sporulation protein p BG11_169 ENOG4105K4P CoA-binding domain protein BG11_1690 ENOG4108Z7R Chaperone CsaA BG11_1694 ENOG4105C37 (CBS) domain BG11_1695 ENOG4105SXS Protein of unknown function (DUF456) BG11_1699 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BG11_17 ENOG4107YEI lmbE family BG11_170 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BG11_1700 ENOG4108S4H thioesterase Superfamily protein BG11_1702 ENOG4108PJD permease BG11_1705 ENOG4107T5V SNARE associated Golgi BG11_1709 ENOG4107TB6 phosphoglycerate mutase BG11_1714 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BG11_1716 ENOG4105K4T epimerase BG11_1718 ENOG4105DSE periplasmic solute binding protein BG11_172 ENOG4105D9R oxidoreductase BG11_1730 ENOG4105CKI cobalamin synthesis protein BG11_1731 ENOG4107QM2 Aldo Keto reductase BG11_1735 ENOG4105DEN Luciferase family BG11_1738 ENOG4108WPJ Ferritin-like domain BG11_1739 ENOG4108K88 Membrane BG11_174 ENOG4105CIG ABC transporter BG11_1742 ENOG4105C8Q Methyl-accepting chemotaxis BG11_1747 ENOG4107XZQ multidrug resistance protein BG11_1748 ENOG4107SET aldo keto reductase BG11_1749 ENOG4105YVS arsR family transcriptional regulator BG11_1751 ENOG4105KRN Transcriptional regulator, abrb family BG11_1761 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BG11_1763 ENOG4105YWU small acid-soluble spore protein BG11_1764 ENOG4108WBH protein TIM barrel BG11_1767 ENOG4105CEY Amp-dependent synthetase and ligase BG11_1768 ENOG4105DUU IucA IucC family protein BG11_1770 ENOG4105VRR gCN5-related N-acetyltransferase BG11_1771 ENOG4105KT7 mgtC SapB transporter BG11_1773 ENOG4107VMI polysaccharide deacetylase BG11_1774 ENOG4105BZU Histidine kinase BG11_1775 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG11_1777 ENOG4108KGH TRANSCRIPTIONal BG11_178 ENOG4105EMN RNA polymerase sigma factor BG11_1782 ENOG4105D6E homoserine dehydrogenase BG11_1785 ENOG4106AKJ BG11_1786 ENOG4108ZJ4 polysaccharide deacetylase BG11_1787 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BG11_1790 ENOG4105BZU Histidine kinase BG11_1791 ENOG4105EFI regulatoR BG11_1792 ENOG4105BZ1 (ABC) transporter BG11_18 ENOG4107TTQ Alpha beta hydrolase fold BG11_180 ENOG4108KGH TRANSCRIPTIONal BG11_1800 ENOG4108JJ8 (ABC) transporter BG11_1801 ENOG4108JJ9 ABC, transporter BG11_1802 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BG11_1803 ENOG4105C4M (Ubiquinol oxidase) subunit I BG11_1809 ENOG4105SKE transcriptional Regulator LysR family BG11_181 ENOG4107QJT sodium dicarboxylate symporter BG11_1811 ENOG4105C32 Amino acid ABC transporter (Permease) BG11_1812 ENOG4108IV0 ABC, transporter BG11_1813 ENOG4105C0Z ABC transporter BG11_1815 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BG11_1816 ENOG4108Z7G MaoC domain protein dehydratase BG11_1820 ENOG4105CKI cobalamin synthesis protein BG11_1822 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BG11_1823 ENOG4106F5Q Membrane BG11_1824 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BG11_1827 ENOG4108TVJ Nitroreductase BG11_1828 ENOG4107ZXU DSBA oxidoreductase BG11_1829 ENOG4108Z40 Transcriptional regulator BG11_1830 ENOG4105GZI Transcriptional regulator BG11_1831 ENOG4107RT3 EamA-like transporter family BG11_1832 ENOG4105KTB nuclear export factor GLE1 BG11_1833 ENOG4108T5E Copper resistance protein BG11_184 ENOG4105DQ6 Transposase BG11_1842 ENOG4107R16 Multicopper oxidase BG11_1843 ENOG4107RAQ aminopeptidase BG11_1849 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BG11_1850 ENOG4105D9N nucleoside BG11_1852 ENOG4107RHR regulatoR BG11_1857 ENOG4105C0X amino acid BG11_1859 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BG11_1861 ENOG4105C72 UPF0176 protein BG11_1862 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BG11_1866 ENOG41068WN BG11_1875 ENOG4105CYC Transferase BG11_1876 ENOG4105DY9 regulatoR BG11_1878 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BG11_1879 ENOG4105C6X Major Facilitator BG11_1884 ENOG4105C7B Threonine dehydratase BG11_1886 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BG11_1887 ENOG4108ZP8 Acetolactate synthase small subunit BG11_1888 ENOG4105C7K acetolactate synthase BG11_1889 ENOG4105CM2 brancheD-chain amino acid aminotransferase BG11_1890 ENOG4105CHR reductase BG11_1891 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BG11_1895 ENOG4105H67 Protein of unknown function (DUF421) BG11_1896 ENOG4105X5K response regulator receiver protein BG11_1898 ENOG4105C8J )-transporter BG11_1902 ENOG4105C6T cysteine synthase BG11_1903 ENOG4105EU0 Major facilitator Superfamily BG11_1905 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BG11_1908 ENOG4105DXI Major Facilitator superfamily BG11_1909 ENOG4105CSR polyphosphate kinase 2 BG11_1917 ENOG4105FVX BG11_1929 ENOG4105C6K Malic enzyme BG11_1930 ENOG4108IJ0 Aspartate ammonia-lyase BG11_1932 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BG11_1936 ENOG4105CJ1 ABC, transporter BG11_1943 ENOG4106BRA Membrane BG11_1949 ENOG4107QIV Cytochrome c biogenesis protein BG11_1953 ENOG4105EC3 peptidase S51, dipeptidase E BG11_1954 ENOG4107QJQ Mate efflux family protein BG11_1958 ENOG4105C9Q fumarate hydratase class II BG11_196 ENOG4105E1K spore germination protein BG11_1960 ENOG4105VUF Transcriptional regulator BG11_1961 ENOG4105DFD Na H antiporter BG11_1964 ENOG4108PJD permease BG11_1965 ENOG4105CKI cobalamin synthesis protein BG11_1966 ENOG4108UZ3 Transporter BG11_1967 ENOG4105DRR Transcriptional regulator, GntR family BG11_1969 ENOG4105PGM cation diffusion facilitator family transporter BG11_1973 ENOG4105CAQ asparagine synthetase BG11_1975 ENOG4105K56 Transcriptional regulator BG11_1979 ENOG4105CVJ phosphoglycerate mutase BG11_198 ENOG4108JB9 formate dehydrogenase BG11_1986 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BG11_1987 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BG11_1989 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BG11_1990 ENOG4105DUM transcriptional regulator, lysR family BG11_1995 ENOG4105KAC Antibiotic biosynthesis monooxygenase BG11_2 ENOG4105DQU oxidoreductase, subunit beta BG11_200 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BG11_2002 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BG11_2003 ENOG4105KTQ flagellar basal-body rod protein BG11_2004 ENOG4105FZW flagellar biosynthesis regulator FlhF BG11_2005 ENOG4105D7B Flagellar biosynthesis protein flha BG11_2006 ENOG4105D00 flagellar biosynthetic protein flhB BG11_2008 ENOG4105VS8 Flagellar biosynthetic protein fliq BG11_2009 ENOG4105CN7 Flagellar biosynthetic protein FliP BG11_201 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BG11_2011 ENOG4105DD5 Flagellar motor switch protein BG11_2012 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BG11_2014 ENOG4105E4C Lytic transglycosylase catalytic BG11_2015 ENOG4105I03 Flagellin BG11_2016 ENOG4105I03 Flagellin BG11_2018 ENOG4107R88 Chemotaxis protein (CheV) BG11_2021 ENOG4105BZE flagellar hook protein, FlgE BG11_2027 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BG11_2028 ENOG4107U2N Flagellar M-ring protein BG11_2029 ENOG41075Z6 flagellar hook-basal body complex protein fliE BG11_203 ENOG4105TMB Formate nitrite transporter BG11_2030 ENOG4108ZC9 flagellar basal-body rod protein flgc BG11_2031 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BG11_2034 ENOG4107TPX flagellar hook-associated BG11_2035 ENOG4105DTJ flagellar hook-associated protein BG11_2036 ENOG4105E1Q flagellar hook-associated protein BG11_204 ENOG4105D06 uba thif-type nad fad binding protein BG11_2040 ENOG4105BZU Histidine kinase BG11_2043 ENOG4105DD5 Flagellar motor switch protein BG11_2044 ENOG4105CBS Chea signal transduction histidine kinase BG11_2045 ENOG4107YTP response regulator receiver protein BG11_2046 ENOG4105ER2 Ompa motb domain protein BG11_2047 ENOG4107R0U MotA TolQ exbB proton channel BG11_2049 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BG11_205 ENOG4105CVM Molybdenum cofactor synthesis domain protein BG11_206 ENOG4108ZAF Molybdopterin BG11_2060 ENOG41080C8 DUF218 domain BG11_2061 ENOG4105H67 Protein of unknown function (DUF421) BG11_2063 ENOG4108Z5V transcriptional regulator, merr family BG11_2064 ENOG4105CN5 Metallo-Beta-Lactamase BG11_2065 ENOG4107RWR Sodium hydrogen exchanger BG11_2067 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BG11_208 ENOG4105D1F ATP-binding protein BG11_2080 ENOG41081VK Ribonuclease BG11_2084 ENOG4108SZE gCN5-related N-acetyltransferase BG11_2087 ENOG4105CPK Glycosyl transferase (Group 1 BG11_2099 ENOG4106032 Glutathionylspermidine synthase BG11_21 ENOG41067MG lrgb family BG11_2102 ENOG4105KHC sulfurtransferase BG11_2104 ENOG4108W0I acetyltransferase BG11_2106 ENOG410890F Dynamin family BG11_2108 ENOG4105DHF Membrane BG11_2109 ENOG4105C2W permease BG11_211 ENOG4105FR1 rard protein BG11_2111 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BG11_2114 ENOG4105CTD carboxy-peptidase BG11_2115 ENOG4105DVT helicase BG11_2117 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BG11_2128 ENOG4105BZ4 penicillin-binding protein BG11_213 ENOG4105EWU Squalene--hopene cyclase BG11_2130 ENOG4105CSM endonuclease III BG11_2134 ENOG4105YAC BG11_2135 ENOG4105DVT helicase BG11_214 ENOG4105CHR reductase BG11_2142 ENOG4105CPK Glycosyl transferase (Group 1 BG11_2143 ENOG4105FJR Lmbe family BG11_2146 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BG11_2147 ENOG4108JYZ YitT family BG11_215 ENOG4105C26 Dehydrogenase BG11_2153 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BG11_2154 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BG11_2155 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BG11_2158 ENOG41068YB TPR repeat-containing protein BG11_2159 ENOG4105CIH Imidazole acetol-phosphate transaminase BG11_2163 ENOG4105EAH synthase BG11_2165 ENOG4105XXQ heptaprenyl diphosphate synthase component I BG11_2168 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BG11_217 ENOG4108IA2 Sodium pantothenate symporter BG11_2174 ENOG41065D1 BG11_2175 ENOG4105S2F BG11_2182 ENOG4107RB3 L-asparaginase BG11_2183 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BG11_2188 ENOG4108S6Z Negative regulator of genetic competence BG11_2189 ENOG4107X2D transcriptional regulator, merr family BG11_2190 ENOG4107RGJ metallophosphoesterase BG11_2192 ENOG4105I7S Abortive infection protein BG11_2193 ENOG4105C9U ATP-dependent DNA helicase RecQ BG11_2196 ENOG4108SAX Membrane BG11_2198 ENOG41063SB peptidase BG11_2199 ENOG4108WBT adenosyltransferase BG11_220 ENOG4106IQC argininosuccinate lyase BG11_2200 ENOG4105BZU Histidine kinase BG11_2201 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG11_2202 ENOG4105CRE cytochrome C BG11_2203 ENOG4107TWT Cytochrome c biogenesis protein BG11_2205 ENOG4105FE9 pseudouridine synthase BG11_2207 ENOG4108JIC nucleoside recognition domain protein BG11_2208 ENOG4105DZ1 carboxypeptidase BG11_2209 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BG11_2216 ENOG4105BZU Histidine kinase BG11_2219 ENOG4105I3N Conserved Protein BG11_222 ENOG410904N short-chain dehydrogenase reductase BG11_2220 ENOG4105BZU Histidine kinase BG11_2223 ENOG4105BZ4 penicillin-binding protein BG11_2224 ENOG4107GRR phosphate transport regulator BG11_2225 ENOG4105CJ3 phosphate transporter BG11_2234 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BG11_2238 ENOG4105WH1 Two component transcriptional regulator luxr family BG11_2239 ENOG4105ENE Histidine kinase BG11_2243 ENOG4105DFD Na H antiporter BG11_2247 ENOG4105C8J )-transporter BG11_2248 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BG11_2249 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BG11_2250 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BG11_2252 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BG11_2253 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BG11_2257 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BG11_2259 ENOG4105E0M Sulfatase BG11_226 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BG11_2260 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BG11_2263 ENOG4107RVV histidinol phosphate phosphatase, hisj family BG11_2278 ENOG4108ZP8 Acetolactate synthase small subunit BG11_2279 ENOG4105C7K acetolactate synthase BG11_2280 ENOG4105CM2 brancheD-chain amino acid aminotransferase BG11_2284 ENOG4105KBJ sporulation protein ytfj BG11_2285 ENOG41063Y9 BG11_2286 ENOG4105CZN Potassium uptake protein BG11_2292 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BG11_2293 ENOG4107QMU Mate efflux family protein BG11_230 ENOG4105VEQ Cold shock protein BG11_2300 ENOG4105NQC Flavodoxin BG11_2305 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BG11_2307 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BG11_2308 ENOG4105EA8 2-Nitropropane dioxygenase BG11_2309 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BG11_2317 ENOG4105CJ1 ABC, transporter BG11_2319 ENOG4105CZV ABC transporter BG11_2320 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BG11_2321 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BG11_2322 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BG11_2324 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BG11_2325 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BG11_2333 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BG11_2334 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BG11_2336 ENOG4105BZU Histidine kinase BG11_2338 ENOG4106DF1 BG11_234 ENOG4108R1P BG11_2340 ENOG41090MY MarR family Transcriptional regulator BG11_2341 ENOG4105BZU Histidine kinase BG11_2343 ENOG4105PXI polysaccharide deacetylase BG11_2345 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BG11_2348 ENOG4105E98 transcriptional regulator DeoR family BG11_2351 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BG11_2352 ENOG4107RCV ABC transporter, permease BG11_2353 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BG11_2354 ENOG4105C4Y ABC transporter BG11_2358 ENOG4105MWK D-amino acid dehydrogenase, small subunit BG11_236 ENOG41073R8 VanW family BG11_2360 ENOG4105CHR reductase BG11_2364 ENOG4108Z7G MaoC domain protein dehydratase BG11_2365 ENOG410681C small acid-soluble spore protein BG11_2366 ENOG4105CZN Potassium uptake protein BG11_2367 ENOG4107TS3 membrane protein, TerC BG11_2368 ENOG4108QTI )-transporter BG11_237 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BG11_2370 ENOG4106A3R peptidase BG11_2374 ENOG4105JXH GntR family transcriptional regulator BG11_2375 ENOG4105BZU Histidine kinase BG11_2376 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG11_2379 ENOG4105CQB FAD linked oxidase domain protein BG11_2380 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BG11_2381 ENOG4105K4I Scp-like extracellular BG11_2383 ENOG4108YBP pseudouridine synthase BG11_2385 ENOG4105EYF MMPL domain protein BG11_2387 ENOG4107RUE extracellular solute-binding protein family 1 BG11_2388 ENOG4105D38 putrescine abc transporter BG11_2389 ENOG4105F38 ABC transporter, permease BG11_2391 ENOG4105C26 Dehydrogenase BG11_2397 ENOG4105VFR signal peptidase BG11_2398 ENOG4105DZ1 carboxypeptidase BG11_24 ENOG4105BZU Histidine kinase BG11_240 ENOG4105KT7 mgtC SapB transporter BG11_2400 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BG11_2403 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BG11_2407 ENOG4105EFC phage portal protein HK97 family BG11_2414 ENOG4108NE4 BG11_242 ENOG4105E39 Enoyl-CoA hydratase BG11_243 ENOG4105K64 Glycosyl transferase, family 2 BG11_2434 ENOG4105VZ8 Transcriptional regulator BG11_2436 ENOG4105C7S Dehydrogenase BG11_245 ENOG4108UT6 Transferase hexapeptide repeat containing protein BG11_2456 ENOG4105DDQ anthranilate synthase BG11_2457 ENOG4105CRQ synthase (Component I) BG11_2458 ENOG4105CK7 Sodium proline symporter BG11_2472 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BG11_2474 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BG11_2475 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BG11_2479 ENOG4107TVC Glycosyl transferase, family 2 BG11_2483 ENOG4105K64 Glycosyl transferase, family 2 BG11_2487 ENOG4105EMS pseudouridine synthase BG11_2488 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BG11_2491 ENOG4105MIX Adenylate cyclase BG11_2492 ENOG4108Z18 K06886 hemoglobin BG11_2495 ENOG4105DPN Oligoendopeptidase f BG11_2497 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BG11_2499 ENOG4108ZCF integral membrane protein BG11_25 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BG11_2503 ENOG4105UQX Mate efflux family protein BG11_2504 ENOG4108JQ7 (ABC) transporter BG11_2506 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG11_2507 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BG11_251 ENOG4105C09 Bile acid BG11_2510 ENOG4105C31 Tryptophanyl-tRNA synthetase BG11_2513 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BG11_2514 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BG11_2519 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BG11_2521 ENOG4108KP7 hydrolase BG11_2523 ENOG41073B9 BG11_2524 ENOG4107AYK membrAne BG11_2526 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BG11_2528 ENOG4105QNR S1 RNA binding domain protein BG11_253 ENOG4105RHY Pfam:UPF0157 BG11_2532 ENOG4105BZU Histidine kinase BG11_2533 ENOG4105CH6 catalase BG11_2534 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BG11_2535 ENOG4105CAQ asparagine synthetase BG11_2540 ENOG4105ERH Fumarylacetoacetate hydrolase BG11_2554 ENOG4105XVF Competence transcription factor BG11_2558 ENOG4105VEQ Cold shock protein BG11_2561 ENOG4107QP3 malate synthase g BG11_2562 ENOG4105ZU5 s-layer protein BG11_2566 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BG11_2571 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG11_2575 ENOG41086D8 Transcriptional regulator BG11_2576 ENOG4108AEY RNA polymerase sigma factor BG11_2578 ENOG4107TVP HD domain protein BG11_258 ENOG4105CIS alcohol dehydrogenase BG11_2580 ENOG4107RN3 metallophosphoesterase BG11_2581 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) BG11_2588 ENOG4105CNA YD repeat protein BG11_259 ENOG41082BM Transcriptional regulator, arsr family BG11_2591 ENOG4105CNA YD repeat protein BG11_2600 ENOG4105CEY Amp-dependent synthetase and ligase BG11_2602 ENOG4105DF9 Lipoate-protein, ligase BG11_2603 ENOG4108RQ5 Beta-lactamase domain-containing protein BG11_2604 ENOG4106AXD BG11_2606 ENOG4105D29 Helix-turn-helix type 11 domain protein BG11_2608 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BG11_2612 ENOG4105ECB domain protein BG11_2619 ENOG4105C1Q protoporphyrinogen oxidase BG11_2622 ENOG4105BZ4 penicillin-binding protein BG11_2623 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BG11_2624 ENOG4105CKV Membrane BG11_2625 ENOG410905X membrane-flanked domain protein BG11_263 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BG11_2633 ENOG4105CKV Membrane BG11_2634 ENOG410905X membrane-flanked domain protein BG11_2649 ENOG4105K59 histidine triad (HIT) protein BG11_2654 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BG11_2655 ENOG4105EEM helicase BG11_2657 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG11_2658 ENOG4105C57 major facilitator superfamily BG11_2661 ENOG4105CNI cell division protein FtsW BG11_2663 ENOG4105EMN RNA polymerase sigma factor BG11_2665 ENOG4105DQ6 Transposase BG11_2666 ENOG4105IYK transposase BG11_2667 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BG11_2670 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BG11_2674 ENOG4108MUZ hydrolase BG11_2685 ENOG4106D4I domain protein BG11_2686 ENOG4107VRP DNA repair exonuclease BG11_269 ENOG4108A04 Beta-lactamase BG11_2695 ENOG4105K8R UPF0145 protein BG11_270 ENOG4105DPN Oligoendopeptidase f BG11_2700 ENOG4105BZU Histidine kinase BG11_2701 ENOG4105BZU Histidine kinase BG11_2702 ENOG4108MJI response regulator BG11_2704 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG11_2706 ENOG4105WN5 stage II sporulation protein BG11_271 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BG11_2719 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BG11_272 ENOG4105E5K Alpha-amylase BG11_2721 ENOG4105CMT Dihydroxyacetone kinase BG11_2723 ENOG4105CMT Dihydroxyacetone kinase BG11_2729 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BG11_274 ENOG4105C98 muts2 protein BG11_2745 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG11_2749 ENOG4105CDU Replicative dna helicase BG11_2760 ENOG4105M6F mutator MutT protein BG11_2762 ENOG4108MRH transcriptional regulatory protein BG11_2764 ENOG4105CSH Transporter BG11_2767 ENOG4108JQ7 (ABC) transporter BG11_2769 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG11_2777 ENOG4105CTU Proline racemase BG11_278 ENOG4107V2S Transcriptional regulator BG11_2781 ENOG4105DER m42 family BG11_2785 ENOG4105CGU Enoyl-CoA hydratase BG11_2788 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BG11_2789 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BG11_2799 ENOG4105CHH sulfate transporter BG11_280 ENOG4107CUJ Protein of unknown function (DUF2690) BG11_2802 ENOG4105D4P Coproporphyrinogen iii oxidase BG11_2803 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BG11_2807 ENOG4107FQX Alpha-acetolactate decarboxylase BG11_2814 ENOG410839P BG11_2817 ENOG4105CDA abc transporter atp-binding protein BG11_2818 ENOG4105DRP amino acid AbC transporter BG11_2820 ENOG4105BZ1 (ABC) transporter BG11_2821 ENOG4105BZ1 (ABC) transporter BG11_2822 ENOG4105C26 Dehydrogenase BG11_2824 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BG11_2825 ENOG4105D5Q Arginine ornithine antiporter BG11_2827 ENOG4105CH6 catalase BG11_2828 ENOG4107RKG DJ-1/PfpI family BG11_2830 ENOG4105E5W Transporter BG11_2831 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BG11_2833 ENOG4105NF4 modulator of drug activity BG11_2838 ENOG4105KPY Small multidrug resistance protein BG11_2839 ENOG4105KPY Small multidrug resistance protein BG11_2841 ENOG4108YXU transcriptional regulator AsnC family BG11_2849 ENOG4106KNT transcriptional regulator BG11_285 ENOG4107ZY0 Phenazine biosynthesis-like protein BG11_2851 ENOG4107RWR Sodium hydrogen exchanger BG11_2852 ENOG4105CUB amino acid BG11_2859 ENOG4107T5V SNARE associated Golgi BG11_286 ENOG4105NX3 Membrane BG11_2866 ENOG4105WEF catalase BG11_287 ENOG4105DQ5 transport system permease protein BG11_2872 ENOG4105C19 ABC transporter BG11_2873 ENOG4107RBB ABC transporter, permease BG11_2874 ENOG41069ER domain protein BG11_2878 ENOG4105VZJ PTS System BG11_2879 ENOG4105VCP PTS System BG11_288 ENOG4105EHG Permease protein BG11_2880 ENOG4105EMD TRANSCRIPTIONal BG11_2885 ENOG4108KGH TRANSCRIPTIONal BG11_2887 ENOG41087NI Sulfite exporter TauE/SafE BG11_2888 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BG11_289 ENOG4108MES Periplasmic binding protein BG11_2890 ENOG41085GJ domain protein BG11_2891 ENOG4105VFE sira family BG11_2892 ENOG4107TPS domain protein BG11_2893 ENOG4105VFE sira family BG11_2894 ENOG4105XTG Pfam:DUF156 BG11_2895 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BG11_2897 ENOG4108TCS Glutamyl endopeptidase BG11_2899 ENOG4105ED1 spovr family BG11_2900 ENOG4107Y03 Nitroreductase BG11_2904 ENOG4108B31 Spore germination protein BG11_2911 ENOG4108PXI ErfK YbiS YcfS YnhG BG11_2913 ENOG4105C7N Xanthine uracil vitamin C permease BG11_2916 ENOG4108INS Transcriptional regulator BG11_292 ENOG4107R3E Citrate transporter BG11_2925 ENOG4105DWF phosphomethylpyrimidine kinase BG11_2926 ENOG4105D06 uba thif-type nad fad binding protein BG11_2929 ENOG41080HI glycine oxidase BG11_2930 ENOG4108VEU Thiamine monophosphate synthase BG11_2932 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BG11_2934 ENOG4105ETU transcriptional activator (TenA BG11_2938 ENOG41080XQ Signal transduction protein with cbs domains BG11_294 ENOG4108TN2 lmbE family BG11_2964 ENOG4105E2Z phosphate ABC transporter (Permease BG11_2965 ENOG4105C8U phosphate abc transporter BG11_2966 ENOG4105CVA phosphate BG11_2967 ENOG4105CE1 Ferrous iron transport protein b BG11_2968 ENOG4105CE1 Ferrous iron transport protein b BG11_2969 ENOG4105CE1 Ferrous iron transport protein b BG11_2970 ENOG4108NHD germination protein BG11_2973 ENOG4105E1V na solute symporter BG11_2974 ENOG4106CAD Protein of unknown function (DUF3311) BG11_2977 ENOG4105E2S oxidase) subunit II BG11_2978 ENOG4105BZ9 Cytochrome C oxidase, subunit I BG11_2983 ENOG4105MA6 gCN5-related N-acetyltransferase BG11_2986 ENOG4105C7N Xanthine uracil vitamin C permease BG11_2987 ENOG4105C85 amino acid BG11_2991 ENOG4105DUX Transporter BG11_2993 ENOG4107D63 BG11_2994 ENOG4105VZ8 Transcriptional regulator BG11_2995 ENOG41069ER domain protein BG11_2996 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BG11_3008 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BG11_3009 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BG11_301 ENOG4105CIS alcohol dehydrogenase BG11_3010 ENOG4105CNN ABC, transporter BG11_3011 ENOG4105C2J ABC transporter BG11_3013 ENOG4108RVA ribokinase BG11_3014 ENOG4105ETE Transcriptional regulator (LacI family BG11_3015 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG11_3016 ENOG41067TZ transcriptional regulator, MarR family BG11_3017 ENOG4105CXY transporter BG11_3019 ENOG4108JQ7 (ABC) transporter BG11_3020 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BG11_3022 ENOG4105DEF Extracellular solute-binding protein, family 5 BG11_3024 ENOG41068KF Universal stress protein BG11_3025 ENOG4105CHH sulfate transporter BG11_3028 ENOG4105BZU Histidine kinase BG11_3029 ENOG4105NAE bifunctional deaminase-reductase domain protein BG11_3030 ENOG4105D29 Helix-turn-helix type 11 domain protein BG11_3032 ENOG4105GFR rna polymerase sigma factor BG11_3035 ENOG4108IQI permease BG11_3036 ENOG4105DRP amino acid AbC transporter BG11_3037 ENOG4105EAD ABC transporter BG11_3038 ENOG4105CT1 (ABC) transporter BG11_3039 ENOG4105CDA abc transporter atp-binding protein BG11_3040 ENOG4105BZG amino acid carrier protein BG11_3041 ENOG4105CRN Aminoglycoside phosphotransferase BG11_3043 ENOG4105E1K spore germination protein BG11_3046 ENOG4105CG3 alpha amylase, catalytic region BG11_3047 ENOG4105C5Y PTS System BG11_3048 ENOG4107414 GntR family transcriptional regulator BG11_3049 ENOG4105D5Q Arginine ornithine antiporter BG11_3050 ENOG4105BZU Histidine kinase BG11_3053 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BG11_3054 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BG11_3055 ENOG4107T89 von Willebrand factor, type A BG11_3057 ENOG4105EXW epimerase dehydratase BG11_3059 ENOG4105E0A ABC, transporter BG11_3060 ENOG4108IHU transport system permease protein BG11_3061 ENOG4105DQ5 transport system permease protein BG11_3062 ENOG4108MES Periplasmic binding protein BG11_3063 ENOG4105DUX Transporter BG11_3066 ENOG4105DAA L-lactate BG11_3067 ENOG4108IJ0 Aspartate ammonia-lyase BG11_3068 ENOG4105C37 (CBS) domain BG11_3069 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BG11_3070 ENOG4105D9N nucleoside BG11_3071 ENOG4108KGH TRANSCRIPTIONal BG11_3072 ENOG41073R8 VanW family BG11_3079 ENOG4105DAP Nicotinate phosphoribosyltransferase BG11_308 ENOG4105H3G oxidoreductase BG11_3080 ENOG4105C59 p-type ATPase BG11_3082 ENOG4105CUB amino acid BG11_3087 ENOG4108JB9 formate dehydrogenase BG11_3088 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BG11_3089 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BG11_3091 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG11_3092 ENOG4105BZU Histidine kinase BG11_3094 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BG11_3095 ENOG4108UZ3 Transporter BG11_3097 ENOG4105C6K Malic enzyme BG11_3099 ENOG4108MRH transcriptional regulatory protein BG11_31 ENOG4105D03 DNA-3-methyladenine glycosylase II BG11_3104 ENOG4105US7 Histidine kinase BG11_3105 ENOG4108STX response regulator BG11_3106 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BG11_3107 ENOG4105BZ7 extracellular solute-binding protein family 1 BG11_3108 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BG11_3109 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BG11_3110 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BG11_3111 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BG11_3115 ENOG4105D4T Citrate transporter BG11_3116 ENOG4108V9W transcriptional regulatory protein BG11_3117 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BG11_3119 ENOG4105DZ6 Band 7 protein BG11_3122 ENOG4105C94 Transporter BG11_3126 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BG11_3148 ENOG4105CAR Terminase, large subunit BG11_3154 ENOG410682Q Phage transcriptional regulator, ArpU BG11_3163 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BG11_3168 ENOG4105CDU Replicative dna helicase BG11_3176 ENOG4108IMY Transcriptional regulator BG11_3182 ENOG4105CYN Serine protein kinase BG11_3184 ENOG4105BZU Histidine kinase BG11_3185 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BG11_3187 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BG11_3189 ENOG4107ZQN disulfide bond BG11_319 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BG11_3190 ENOG4108JQC penicillin-binding protein 1A BG11_32 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BG11_3214 ENOG4105G5W regulator Fur family BG11_3215 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BG11_3219 ENOG4108IUW ABC transporter BG11_3221 ENOG4105CBC glutamate synthase BG11_3222 ENOG4107NBY Membrane BG11_3223 ENOG4105BZ1 (ABC) transporter BG11_3227 ENOG4106BXE BG11_3228 ENOG4105CEN a g-specific adenine glycosylase BG11_3229 ENOG41067AE Membrane-bound metal-dependent hydrolase BG11_3235 ENOG4105ECP epimerase BG11_3236 ENOG4105CI2 imidazolone-5-propionate hydrolase BG11_324 ENOG4105KAF membrAne BG11_3240 ENOG4105F1A Pyruvate formate-lyase BG11_3243 ENOG4105C3I Nad-dependent epimerase dehydratase BG11_3244 ENOG4107QQG Dehydrogenase BG11_3245 ENOG4105CKK Glycosyl transferase, family 2 BG11_3248 ENOG4108A04 Beta-lactamase BG11_3250 ENOG4105CSV Glutaminase BG11_3257 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BG11_3258 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BG11_3265 ENOG4105UPD Calcium Proton BG11_3266 ENOG410606W general stress protein BG11_3269 ENOG4107ZTW SNARE associated Golgi BG11_3274 ENOG4108IPJ Membrane BG11_3275 ENOG4105C59 p-type ATPase BG11_3276 ENOG4107U9T Pfam:Ribonuclease_BN BG11_3278 ENOG4105KJF protein tyrosine phosphatase BG11_3282 ENOG4108TTB tellurium resistance protein BG11_3283 ENOG4107TS3 membrane protein, TerC BG11_3284 ENOG4106FN3 tellurium resistance protein BG11_3285 ENOG4106FN3 tellurium resistance protein BG11_3286 ENOG4108N0M stress protein BG11_3292 ENOG4105DEU major facilitator superfamily BG11_3296 ENOG41062JF Transcriptional regulator BG11_3303 ENOG4105C5H ABC transporter BG11_3306 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BG11_3309 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BG11_3315 ENOG4105CI1 PTS System BG11_3319 ENOG4105C5B carbamate kinase BG11_3324 ENOG4105C8Q Methyl-accepting chemotaxis BG11_3326 ENOG4105EAB amino acid AbC transporter BG11_3327 ENOG4105E5Q amino acid AbC transporter BG11_333 ENOG4108ZJ4 polysaccharide deacetylase BG11_3330 ENOG4105D2S major facilitator superfamily BG11_3331 ENOG410756H nucleotidyltransferase BG11_3339 ENOG4106UIA BG11_3340 ENOG4106UIA BG11_3344 ENOG4108V5C ABC transporter BG11_3345 ENOG4105DQ5 transport system permease protein BG11_3346 ENOG4105EHG Permease protein BG11_3347 ENOG4107W7X Aldolase BG11_3349 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BG11_335 ENOG4105KVH Transcriptional regulator BG11_3350 ENOG4105D3R alkyl hydroperoxide reductase BG11_3355 ENOG4105DFD Na H antiporter BG11_3356 ENOG4105DTQ mandelate racemase muconate lactonizing BG11_3359 ENOG4108W15 Protein of unknown function (DUF1456) BG11_336 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BG11_3362 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BG11_3363 ENOG4105D9N nucleoside BG11_3367 ENOG4105KPY Small multidrug resistance protein BG11_3368 ENOG4105C26 Dehydrogenase BG11_3370 ENOG4108JPW Aminotransferase BG11_3371 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BG11_3372 ENOG4105CBD Diacylglycerol kinase BG11_3376 ENOG4107I77 yiaA/B two helix domain BG11_3377 ENOG410834F Transcriptional regulator BG11_338 ENOG4105KNA -acetyltransferase BG11_3381 ENOG4105D01 (LipO)protein BG11_3382 ENOG4108UMI ABC transporter, permease BG11_3383 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BG11_3384 ENOG4108W2Y isochorismatase BG11_3390 ENOG4105C4R Atp-dependent dna helicase BG11_3395 ENOG4105C12 Phosphoribosylglycinamide synthetase BG11_3397 ENOG4108V3E phosphoribosylglycinamide formyltransferase BG11_34 ENOG4105CGK Exodeoxyribonuclease III BG11_340 ENOG4105CHR reductase BG11_3402 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BG11_3404 ENOG4105C83 adenylosuccinate lyase BG11_3405 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BG11_3406 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BG11_3412 ENOG4105SX7 Transporter BG11_3419 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG11_342 ENOG4105JAB phenazine biosynthesis protein, phzf family BG11_3428 ENOG4107ZXU DSBA oxidoreductase BG11_3434 ENOG4105BZU Histidine kinase BG11_3436 ENOG4105C7N Xanthine uracil vitamin C permease BG11_3440 ENOG4108TYN CAAX amino terminal protease family protein BG11_3443 ENOG4105C5H ABC transporter BG11_3444 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BG11_3445 ENOG410801F ribosomal-protein-alanine acetyltransferase BG11_3446 ENOG41072GX Peptidase M22 Glycoprotease BG11_3447 ENOG4105K8N protein family UPF0079, ATPase BG11_3467 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BG11_3469 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BG11_3470 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BG11_3473 ENOG4107ZXI Rhomboid family BG11_3475 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BG11_3476 ENOG4105CPF Cell wall formation (By similarity) BG11_3477 ENOG4108SC4 )-transporter BG11_3479 ENOG4105ERH Fumarylacetoacetate hydrolase BG11_3480 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BG11_3486 ENOG410667J hydrolase BG11_3487 ENOG4108JQ7 (ABC) transporter BG11_3488 ENOG4105C3U ABC transporter BG11_3489 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG11_349 ENOG4105KVH Transcriptional regulator BG11_3491 ENOG4105DEF Extracellular solute-binding protein, family 5 BG11_3494 ENOG4108KYE ABC-2 type transporter BG11_3495 ENOG41090VJ ABC-2 type transporter BG11_3496 ENOG4105CJ1 ABC, transporter BG11_3497 ENOG4105WH1 Two component transcriptional regulator luxr family BG11_3498 ENOG4105BZU Histidine kinase BG11_3499 ENOG4105C5H ABC transporter BG11_350 ENOG4105KVH Transcriptional regulator BG11_3503 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BG11_3504 ENOG4108RE7 deoxyribonuclease BG11_3507 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BG11_351 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BG11_3511 ENOG4105F6E Acyl-transferase BG11_3518 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BG11_3519 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BG11_352 ENOG4105D9R oxidoreductase BG11_3520 ENOG4105E0C molybdate abc transporter BG11_3522 ENOG4107XDY Nicotinamide Mononucleotide Transporter BG11_3523 ENOG4105II7 pyrroline-5-carboxylate reductase BG11_3525 ENOG4108J59 Extracellular solute-binding protein, family 5 BG11_3526 ENOG4108J59 Extracellular solute-binding protein, family 5 BG11_3528 ENOG4105U5Y Transcriptional regulator BG11_353 ENOG4108TZY GntR Family Transcriptional Regulator BG11_3533 ENOG4108JQ7 (ABC) transporter BG11_3534 ENOG4105C3U ABC transporter BG11_3535 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG11_3536 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BG11_3539 ENOG4105C2C drug resistance transporter, Bcr CflA BG11_3542 ENOG4105IQ5 FAD linked oxidase domain protein BG11_3544 ENOG4105EE1 crotonyl-CoA reductase BG11_3545 ENOG4105D01 (LipO)protein BG11_3546 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BG11_3547 ENOG4108UMI ABC transporter, permease BG11_3548 ENOG4108PSK reductase BG11_3554 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BG11_3555 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BG11_3557 ENOG4105CMG Carbohydrate kinase BG11_3559 ENOG4108VQT Alpha beta hydrolase fold protein BG11_3563 ENOG4107U5W ybbr family BG11_3564 ENOG4105C8B TIGR00159 family BG11_3581 ENOG4108NMV polysaccharide deacetylase BG11_3584 ENOG4105D1F ATP-binding protein BG11_3589 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BG11_3590 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BG11_3591 ENOG4108JJB ABC transporter BG11_3597 ENOG41067V7 50S ribosomal protein L36 BG11_3599 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BG11_360 ENOG4105C44 Serine transporter BG11_3601 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BG11_3606 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BG11_3627 ENOG4105XPM ribosomal protein BG11_3630 ENOG4107Y49 methyltransferase BG11_3635 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BG11_3637 ENOG4105QIV RNA polymerase BG11_3638 ENOG4105M0M Tetracycline resistance protein BG11_3639 ENOG4105C2N RNA methyltransferase TrmH family group 3 BG11_3642 ENOG4105D7W serine acetyltransferase BG11_3646 ENOG4105CTP PilT protein domain protein BG11_3648 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BG11_3651 ENOG4108Z0C Uvrb UvrC protein BG11_367 ENOG4105D4Y metalloprotease BG11_3670 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BG11_3672 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BG11_3673 ENOG4105KRF dihydroneopterin aldolase BG11_3674 ENOG4105EEI dihydropteroate synthase BG11_3675 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BG11_3676 ENOG4105DDQ anthranilate synthase BG11_3677 ENOG4105CRQ synthase (Component I) BG11_3678 ENOG4105C6T cysteine synthase BG11_368 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BG11_3681 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BG11_3682 ENOG4108UGV hypoxanthine phosphoribosyltransferase BG11_3687 ENOG41060GV RNA binding s1 domain protein BG11_3690 ENOG4105VYY sporulation protein yabp BG11_3691 ENOG41082I2 s4 domain protein BG11_3692 ENOG4108IY2 MazG family BG11_3694 ENOG4108M14 stage v sporulation protein t BG11_3695 ENOG4108JA2 transcriptioN-repair coupling factor BG11_3698 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BG11_3701 ENOG4105KME endoribonuclease L-psp BG11_3702 ENOG4105DFT pur operon repressor BG11_3705 ENOG4105W42 Veg protein BG11_3706 ENOG4105XFA sporulation peptidase YabG BG11_3708 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BG11_3709 ENOG4105F8V Hydrolase, tatD family BG11_371 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BG11_3711 ENOG4105KRN Transcriptional regulator, abrb family BG11_3712 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BG11_3714 ENOG41060K3 Methyltransferase BG11_3716 ENOG4105MA4 psp1 domain protein BG11_3717 ENOG4105FA2 dna polymerase iii BG11_3719 ENOG4105CXN decarboxylase BG11_3727 ENOG41067KS pro-sigma K processing BG11_373 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BG11_3731 ENOG4105C6E dna polymerase iii BG11_3732 ENOG4108Z6B deaminase BG11_3733 ENOG4105GTG Isochorismatase BG11_3735 ENOG4105ZMH deoxynucleoside kinase BG11_3742 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BG11_3750 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BG11_3753 ENOG410848D S4 domain protein YaaA BG11_3754 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BG11_3758 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BG11_376 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BG11_3760 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BG11_3764 ENOG4107QJE Chromosome Partitioning Protein BG11_3765 ENOG4105FA0 parb-like partition protein BG11_3766 ENOG4108ZDA Sporulation protein YyaC BG11_3767 ENOG4105D8X mechanosensitive ion channel BG11_3768 ENOG4105VDK protein, conserved in bacteria BG11_3769 ENOG4105C3G gtp-binding protein BG11_377 ENOG4105C6Z Gluconate BG11_3771 ENOG4108UUM single-stranded DNA-binding protein BG11_3773 ENOG4108XMW Membrane BG11_3774 ENOG4105BZR domain protein BG11_3776 ENOG4105CDU Replicative dna helicase BG11_378 ENOG4105CMG Carbohydrate kinase BG11_3782 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG11_3783 ENOG4105BZU Histidine kinase BG11_3786 ENOG4105Q2H domain protein BG11_3787 ENOG4105C0H protease BG11_379 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BG11_3791 ENOG4105DPN Oligoendopeptidase f BG11_3794 ENOG4105C1J atp-dependent rna helicase BG11_3796 ENOG4108UT2 hemolysin iii BG11_3797 ENOG4105CMR udp-glucose 4-epimerase BG11_3799 ENOG4105IW1 AmiS UreI transporter BG11_38 ENOG4105E0A ABC, transporter BG11_380 ENOG4105XDF Protein of unknown function (DUF1272) BG11_3801 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BG11_3804 ENOG4107RGD Major Facilitator superfamily BG11_3805 ENOG4108HRK Histidine kinase BG11_3806 ENOG4105DY9 regulatoR BG11_3809 ENOG4106F5Q Membrane BG11_381 ENOG4105DDN Pentapeptide repeat-containing protein BG11_3810 ENOG4105E0X reductase BG11_3812 ENOG41067SE Tetr family transcriptional regulator BG11_3813 ENOG4105CKK Glycosyl transferase, family 2 BG11_3817 ENOG4105C5H ABC transporter BG11_3818 ENOG4105JEU Glycosyl transferase, family 2 BG11_3820 ENOG4108S4H thioesterase Superfamily protein BG11_3822 ENOG4106YBV Methyl-accepting chemotaxis BG11_3823 ENOG4105EN6 Membrane BG11_3827 ENOG41079KZ Major Facilitator Superfamily BG11_3828 ENOG4105DY9 regulatoR BG11_3829 ENOG4105D22 carbon starvation protein BG11_3830 ENOG4105VCD cytoplasmic protein BG11_3831 ENOG4105BZU Histidine kinase BG11_3832 ENOG4105DWF phosphomethylpyrimidine kinase BG11_3833 ENOG4105BZU Histidine kinase BG11_3834 ENOG4105WH1 Two component transcriptional regulator luxr family BG11_3836 ENOG4108Y4K DNA-binding transcriptional activator BG11_384 ENOG4105C37 (CBS) domain BG11_3841 ENOG4105D6E homoserine dehydrogenase BG11_3844 ENOG41090WU lipolytic protein G-D-S-L family BG11_3845 ENOG4105CJ1 ABC, transporter BG11_3846 ENOG4108TU7 Inherit from COG: (ABC) transporter BG11_3848 ENOG4105VCH membrane BG11_3849 ENOG410667J hydrolase BG11_3851 ENOG4107SVH Potassium channel protein BG11_3855 ENOG4108VKI Cell wall hydrolase BG11_3858 ENOG4108IJ2 phosphate acetyltransferase BG11_3862 ENOG4108VCI transcription factor, rsfa family BG11_3864 ENOG4105DQ5 transport system permease protein BG11_3865 ENOG4105EHG Permease protein BG11_3866 ENOG4105E0A ABC, transporter BG11_3867 ENOG4108MES Periplasmic binding protein BG11_3868 ENOG4105DCI Phosphohydrolase BG11_3869 ENOG41069HH 4-oxalocrotonate tautomerase BG11_3870 ENOG4108Z4T Peptidase M50 BG11_3871 ENOG4108XFG YwhD family BG11_3872 ENOG4105BZ4 penicillin-binding protein BG11_3873 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BG11_3874 ENOG4107SWG transcriptional regulator MERR family BG11_3875 ENOG4105DXB Major Facilitator superfamily BG11_3877 ENOG4105CYW agmatinase BG11_3881 ENOG410684U Domain of unknown function (DUF1934) BG11_3883 ENOG4105EMN RNA polymerase sigma factor BG11_3887 ENOG4105IIU Aminopeptidase BG11_3889 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BG11_3890 ENOG4108M15 ABC transporter BG11_3894 ENOG4105BZU Histidine kinase BG11_3897 ENOG4105DF6 Fe-S oxidoreductase BG11_3899 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BG11_39 ENOG4105NIV Esterase BG11_390 ENOG4105EV4 Multidrug resistance protein mdtH BG11_3900 ENOG4105C1G acyl-Coa dehydrogenase BG11_3901 ENOG4105C1G acyl-Coa dehydrogenase BG11_3908 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BG11_3909 ENOG4105CBT Fructose-1,6-bisphosphatase BG11_3910 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BG11_3913 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BG11_3914 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BG11_3915 ENOG4108ZXQ stage ii sporulation protein r BG11_3917 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BG11_392 ENOG4105DMQ Methyltransferase BG11_3920 ENOG4107XC4 flavin reductase domain protein, FMN-binding BG11_3921 ENOG4108VGI doxx family BG11_3924 ENOG4108YZG isomerase BG11_3929 ENOG41062M3 atp synthase BG11_3930 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BG11_3940 ENOG4105BZU Histidine kinase BG11_3941 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BG11_3943 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BG11_3944 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BG11_3949 ENOG4105D65 subunit l BG11_3950 ENOG4105C8S subunit m BG11_3951 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BG11_3952 ENOG4106778 Protein of unknown function (DUF1146) BG11_3956 ENOG4105DY9 regulatoR BG11_3959 ENOG4105FRN stage II sporulation protein BG11_3960 ENOG4107BJW polysaccharide deacetylase BG11_3961 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BG11_3963 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BG11_3964 ENOG4107RZX Teichoic acid biosynthesis protein BG11_3965 ENOG4107SJB teichoic acid biosynthesis BG11_3966 ENOG4107SJB teichoic acid biosynthesis BG11_3968 ENOG4105EY8 ABC transporter BG11_3969 ENOG4107VDP teichoic acid biosynthesis BG11_3970 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BG11_3973 ENOG4105CMR udp-glucose 4-epimerase BG11_3974 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG11_3975 ENOG4105BZU Histidine kinase BG11_3978 ENOG4105CXY transporter BG11_398 ENOG4105C31 Tryptophanyl-tRNA synthetase BG11_3980 ENOG4105C19 ABC transporter BG11_3981 ENOG4107RBB ABC transporter, permease BG11_3984 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG11_3990 ENOG4105C0D helicase BG11_3991 ENOG4105KBK Zinc finger, swim domain protein BG11_3996 ENOG41069ER domain protein BG11_3997 ENOG4105C94 Transporter BG11_3999 ENOG4107R8N Glycosyl transferase, family 2 BG11_400 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BG11_4004 ENOG4105E0M Sulfatase BG11_4006 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BG11_4008 ENOG4105DAA L-lactate BG11_4010 ENOG4105DAA L-lactate BG11_4017 ENOG4107RSM transcriptional regulator BG11_4018 ENOG4105ECB domain protein BG11_4019 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BG11_402 ENOG4108UW5 maltose o-acetyltransferase BG11_4022 ENOG4105VZJ PTS System BG11_4024 ENOG4105VCP PTS System BG11_4026 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BG11_4028 ENOG4105CK1 PTS System BG11_4029 ENOG4105VCP PTS System BG11_403 ENOG4106UW1 Major Facilitator superfamily BG11_4030 ENOG4105F8D glycoside hydrolase family 4 BG11_4034 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BG11_4035 ENOG4108ZJ4 polysaccharide deacetylase BG11_4036 ENOG4105ESV Glycosyl transferase, family 4 BG11_4037 ENOG4105C6Y Udp-glucose 6-dehydrogenase BG11_4038 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BG11_4039 ENOG4108KGH TRANSCRIPTIONal BG11_404 ENOG4105DKQ ROK family BG11_4040 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BG11_4042 ENOG4105KVH Transcriptional regulator BG11_4045 ENOG41081UC Inherit from COG: Competence protein BG11_4046 ENOG4105VEQ Cold shock protein BG11_4047 ENOG4105MS2 ribosomal subunit Interface protein BG11_4049 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BG11_405 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BG11_4051 ENOG4105CAK Cell division ATP-binding protein ftsE BG11_4052 ENOG4105CRP Part of the ABC transporter FtsEX involved in BG11_4053 ENOG4105CN1 protease BG11_4055 ENOG4105BZ1 (ABC) transporter BG11_4058 ENOG4108WS4 fmn reductase BG11_4060 ENOG4105DUM transcriptional regulator, lysR family BG11_4061 ENOG4105HMI Membrane BG11_4067 ENOG4107TXC Transcriptional regulator BG11_4070 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BG11_4071 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BG11_4073 ENOG41086DT Membrane protein of unknown function BG11_4077 ENOG4108S4C acetyltransferase BG11_4079 ENOG4105C3M thioredoxin reductase BG11_4081 ENOG4108Z4K mutator MutT protein BG11_4083 ENOG4105CHW UPF0052 protein BG11_4085 ENOG4105KRI phosphocarrier protein (HPr BG11_4086 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BG11_4087 ENOG4105H67 Protein of unknown function (DUF421) BG11_4090 ENOG4105CZ3 stage V sporulation protein ad BG11_4091 ENOG41090VF Stage v sporulation protein ac BG11_4095 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG11_41 ENOG4105VPX protein, conserved in bacteria BG11_4101 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BG11_4105 ENOG41067MG lrgb family BG11_4106 ENOG4105XZU Preprotein translocase, subunit SecG BG11_4108 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BG11_4114 ENOG4105CM4 permease protein BG11_4115 ENOG4108IPW abc transporter atp-binding protein BG11_4118 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BG11_4119 ENOG4108MK9 spermidine N(1)-acetyltransferase BG11_4125 ENOG4105C8Q Methyl-accepting chemotaxis BG11_4129 ENOG4105D4A Cell wall formation (By similarity) BG11_4130 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BG11_4133 ENOG4105KVH Transcriptional regulator BG11_4134 ENOG4105F27 Major Facilitator BG11_4135 ENOG4105CV8 reductase BG11_4139 ENOG4108RYK Nad-dependent epimerase dehydratase BG11_4141 ENOG4105D9N nucleoside BG11_4142 ENOG4105D9N nucleoside BG11_4146 ENOG4108URH decarboxylase BG11_4149 ENOG4108RMU ferritin dps family protein BG11_4151 ENOG4105NCW Trka-c domain protein BG11_4152 ENOG4107S91 Sodium hydrogen exchanger BG11_4156 ENOG4105D4Y metalloprotease BG11_4157 ENOG4105VG1 fes assembly suf system protein BG11_4158 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BG11_4159 ENOG4105C8Q Methyl-accepting chemotaxis BG11_4163 ENOG4105BZU Histidine kinase BG11_4164 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG11_4165 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BG11_4167 ENOG4107ZTW SNARE associated Golgi BG11_417 ENOG4105CJ1 ABC, transporter BG11_4175 ENOG4107AYK membrAne BG11_4177 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BG11_4179 ENOG4107R7I amino acid BG11_4180 ENOG4108SUT Major Facilitator Superfamily BG11_4184 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BG11_4188 ENOG4105DZ1 carboxypeptidase BG11_419 ENOG4108PSK reductase BG11_4191 ENOG4105CHU acetyl-coa acetyltransferase BG11_4192 ENOG4105C1G acyl-Coa dehydrogenase BG11_4193 ENOG4108W8B Beta-lactamase domain protein BG11_42 ENOG410681U heavy metal transport detoxification protein BG11_4201 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BG11_4209 ENOG41080E8 Transcriptional regulator, Spx MgsR family BG11_4215 ENOG4108UMI ABC transporter, permease BG11_4216 ENOG4105D01 (LipO)protein BG11_4217 ENOG4105D01 (LipO)protein BG11_4218 ENOG4105C3K feS assembly ATPase SufC BG11_4219 ENOG4105JRK feS assembly protein SufD BG11_4220 ENOG4105C9B Cysteine desulfurase BG11_4221 ENOG4108UNV SUF system FeS assembly protein, NifU family BG11_4222 ENOG4105DIW FeS assembly protein SUFB BG11_4223 ENOG4107R8B 5'-nucleotidase BG11_4224 ENOG4105KZD Domain of unknown function (DUF1805) BG11_4226 ENOG4105FAA peptidase M23 BG11_423 ENOG4108RCM Nitroreductase BG11_4231 ENOG41090T1 Membrane BG11_4232 ENOG4107TXC Transcriptional regulator BG11_4233 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BG11_4234 ENOG4105MMD transcriptional regulator BG11_4237 ENOG4105CBT Fructose-1,6-bisphosphatase BG11_424 ENOG4105KVH Transcriptional regulator BG11_4240 ENOG4105D4U had-superfamily hydrolase, subfamily iia BG11_4242 ENOG4105DYS nad(p)h dehydrogenase (quinone) BG11_4244 ENOG4108W5N phosphatidylglycerophosphatase a BG11_4247 ENOG41083MR nifu domain-containing protein BG11_4252 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BG11_4253 ENOG4105C4B ABC transporter, permease BG11_4254 ENOG4108JJA ABC, transporter BG11_4258 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BG11_4260 ENOG4105EWC Purine nucleoside phosphorylase BG11_4266 ENOG4105CEP NADH dehydrogenase BG11_4269 ENOG41069ER domain protein BG11_4273 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BG11_4276 ENOG4105KA0 thioesterase Superfamily protein BG11_4277 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BG11_428 ENOG4108Z66 YbaK ebsC protein BG11_4280 ENOG4107R3E Citrate transporter BG11_4282 ENOG4105Y38 Kinase-associated protein B BG11_4285 ENOG4105C87 Aminotransferase class I and II BG11_4287 ENOG4108MUZ hydrolase BG11_4288 ENOG4105C5I Dehydrogenase BG11_4289 ENOG4108ZB6 transcriptional regulator AsnC family BG11_429 ENOG4105EKQ RNA-directed DNA polymerase BG11_4290 ENOG4105CHM Aminotransferase BG11_4292 ENOG4105WG9 Conserved Protein BG11_4294 ENOG4107PBV potassium channel BG11_4296 ENOG4105KT7 mgtC SapB transporter BG11_43 ENOG4105C59 p-type ATPase BG11_430 ENOG4108Z4K mutator MutT protein BG11_4304 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BG11_431 ENOG4105K59 histidine triad (HIT) protein BG11_4323 ENOG4105JVQ RNA Polymerase BG11_4325 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BG11_4328 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BG11_4335 ENOG4105VEQ Cold shock protein BG11_4337 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BG11_4338 ENOG4105E4F Isochorismate synthase BG11_4340 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BG11_4341 ENOG4108IPT Naphthoate synthase BG11_4343 ENOG4105DTQ mandelate racemase muconate lactonizing BG11_4349 ENOG41069H0 dihydroorotase EC 3.5.2.3 BG11_4353 ENOG4105FDP GntR family transcriptional regulator BG11_4354 ENOG4105C6Z Gluconate BG11_436 ENOG4108IND Tetr family transcriptional regulator BG11_4363 ENOG41086D8 Transcriptional regulator BG11_4364 ENOG4105C19 ABC transporter BG11_4367 ENOG4107ZTW SNARE associated Golgi BG11_437 ENOG4105EQ0 Major Facilitator superfamily BG11_4372 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BG11_4373 ENOG4108UGV hypoxanthine phosphoribosyltransferase BG11_4378 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG11_4379 ENOG4105BZU Histidine kinase BG11_4387 ENOG41087YS Phage shock protein A BG11_4396 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BG11_4397 ENOG4105C4M (Ubiquinol oxidase) subunit I BG11_4399 ENOG4108V2W Carbonate dehydratase BG11_44 ENOG4105K70 DNA-binding protein BG11_4407 ENOG4107XGZ Hydrolase BG11_4410 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BG11_4412 ENOG4105D2X ABC transporter substrate-binding protein BG11_4415 ENOG4107T7U Sulfatase BG11_4416 ENOG4107S9D Alpha beta hydrolase BG11_4417 ENOG4105BZU Histidine kinase BG11_4418 ENOG4105BZU Histidine kinase BG11_4419 ENOG4105EGD dinuclear metal center protein, YbgI family BG11_4429 ENOG4108RIR Molybdenum cofactor biosynthesis protein BG11_4431 ENOG4105BZF Glycosyl transferase (Group 1 BG11_4432 ENOG4105YVM Phosphoesterase, PA-phosphatase related BG11_4433 ENOG4108Z0R Transferase BG11_4434 ENOG4105E8V Alpha Beta Hydrolase Fold protein BG11_444 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BG11_4440 ENOG4105CIG ABC transporter BG11_4442 ENOG4105N5T Radical SAM Protein BG11_4446 ENOG4105C19 ABC transporter BG11_4449 ENOG4105NCW Trka-c domain protein BG11_4450 ENOG4107S91 Sodium hydrogen exchanger BG11_4451 ENOG410605W Major Facilitator BG11_4457 ENOG4108B31 Spore germination protein BG11_4459 ENOG4105DWV Homoserine O-trans-acetylase BG11_4461 ENOG41085GJ domain protein BG11_4465 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BG11_4466 ENOG4105D06 uba thif-type nad fad binding protein BG11_4468 ENOG4105CVM Molybdenum cofactor synthesis domain protein BG11_4469 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BG11_4470 ENOG4108ZAF Molybdopterin BG11_4474 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BG11_4475 ENOG4108VJ1 Transcriptional regulator (CarD family BG11_4482 ENOG4105CBX hi0933 family BG11_4485 ENOG4105YW5 deoR family transcriptional regulator BG11_4486 ENOG4107QSE Dipeptidase BG11_4488 ENOG4108IUM Glycogen debranching enzyme BG11_4489 ENOG4108V15 phosphotransferase enzyme family BG11_4492 ENOG4105C8F Beta-lactamase domain protein BG11_4498 ENOG4108VDD TRNA binding domain protein BG11_45 ENOG4105TMB Formate nitrite transporter BG11_4507 ENOG4105C88 aminopeptidase BG11_451 ENOG4105DYS nad(p)h dehydrogenase (quinone) BG11_4511 ENOG4105ETE Transcriptional regulator (LacI family BG11_4517 ENOG4105EP9 oxidoreductase BG11_4518 ENOG4107SNB ankyrin repeat protein YahD BG11_4519 ENOG4105BZU Histidine kinase BG11_4520 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG11_4522 ENOG4106HB6 Alpha beta hydrolase BG11_4523 ENOG4105DGU Histone deacetylase BG11_4524 ENOG4105W87 Cbs domain BG11_4525 ENOG4105F1V Acetoin utilization protein BG11_4528 ENOG4105EMN RNA polymerase sigma factor BG11_453 ENOG4105CRW Short chain fatty acid transporter BG11_4530 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BG11_4534 ENOG4105C28 cystathionine BG11_4536 ENOG4105U5Y Transcriptional regulator BG11_4538 ENOG4106KR7 LysR family Transcriptional regulator BG11_4543 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BG11_4545 ENOG4105EFZ amidohydrolase BG11_4548 ENOG4105KBJ sporulation protein ytfj BG11_4549 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BG11_455 ENOG4105KBX Transcriptional regulator, TetR family BG11_4555 ENOG4108JYZ YitT family BG11_456 ENOG4105KPY Small multidrug resistance protein BG11_4564 ENOG4107YZX Universal stress protein BG11_4568 ENOG4105VZ8 Transcriptional regulator BG11_457 ENOG4105RXJ BG11_4570 ENOG41082W1 Cupin 2, conserved barrel domain protein BG11_4579 ENOG4105DC7 peptidase M24 BG11_4586 ENOG4105SFS phosphoesterase RecJ domain protein BG11_4588 ENOG4105VV2 BG11_4589 ENOG4105C0B DNA polymerase III (alpha subunit) BG11_459 ENOG4105CZM Major Facilitator BG11_4590 ENOG4105C6K Malic enzyme BG11_4591 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BG11_4596 ENOG4105FS0 cytoplasmic membrane protein BG11_4597 ENOG4108REF Sporulation integral membrane protein ytvi BG11_4599 ENOG4105BZN citrate synthase BG11_460 ENOG4107MII Sugar-specific transcriptional regulator TrmB BG11_4600 ENOG4108HMX isocitrate dehydrogenase (NADP) BG11_4605 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG11_4606 ENOG4105BZU Histidine kinase BG11_4607 ENOG4105C2M dna polymerase I BG11_4608 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BG11_4610 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BG11_4611 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BG11_4612 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BG11_4616 ENOG4108TDW sporulation protein YtxC BG11_4617 ENOG4105C22 threonyL-tRNA synthetase BG11_4618 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BG11_462 ENOG4108ISG Major Facilitator BG11_4622 ENOG4105CN9 Peptidase m42 family protein BG11_4623 ENOG4108JGH Tetr family transcriptional regulator BG11_4624 ENOG4105CW7 secretion protein, HlyD family BG11_4625 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG11_4632 ENOG4108RWN rrna methyltransferase BG11_4634 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BG11_4635 ENOG4105C5S asparaginyl-tRNA synthetase BG11_4642 ENOG4105DCG PHP domain protein BG11_4645 ENOG4105FE9 pseudouridine synthase BG11_4647 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BG11_4649 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BG11_4652 ENOG4105E0A ABC, transporter BG11_4653 ENOG4105KFN sortase, SrtB family BG11_4656 ENOG4105DR4 Methyltransferase BG11_4659 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG11_4667 ENOG4105S6R Iron-hydroxamate transporter permease subunit BG11_4668 ENOG4105J76 Periplasmic binding protein BG11_4670 ENOG4105CEY Amp-dependent synthetase and ligase BG11_4671 ENOG4107Z3H Transcriptional regulator, TetR family BG11_4672 ENOG41060WC Enoyl-CoA hydratase BG11_4673 ENOG4105BZJ Electron transfer flavoprotein BG11_4674 ENOG4105C10 Electron transfer flavoprotein BG11_4675 ENOG4105K63 Thioredoxin BG11_4678 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BG11_4680 ENOG4105E33 succinate dehydrogenase BG11_4682 ENOG4108VXD carboxy-peptidase BG11_4683 ENOG4105E14 MotA TolQ exbB proton channel BG11_4684 ENOG4105ER2 Ompa motb domain protein BG11_4685 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BG11_4686 ENOG4108IUX (ABC) transporter BG11_4687 ENOG4105RHA ABC transporter, permease BG11_4688 ENOG4108Z40 Transcriptional regulator BG11_4689 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BG11_4691 ENOG4108JCI Transcriptional regulator BG11_4692 ENOG41067S9 phage shock protein C, PspC BG11_4694 ENOG4105DY9 regulatoR BG11_4695 ENOG4108HRK Histidine kinase BG11_4696 ENOG4108JQ7 (ABC) transporter BG11_4699 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG11_470 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BG11_4700 ENOG4105DEF Extracellular solute-binding protein, family 5 BG11_4701 ENOG4105DZC cytosine deaminase BG11_4702 ENOG4105DZC cytosine deaminase BG11_4705 ENOG4105PFC Transcriptional regulator BG11_4710 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BG11_4715 ENOG4105D6J arsenicaL-resistance protein BG11_4718 ENOG41082YX Transcriptional regulator, arsr family BG11_4723 ENOG410904A RNA polymerase BG11_4724 ENOG41089UC methyltransferase, type 11 BG11_4733 ENOG4105KBX Transcriptional regulator, TetR family BG11_4735 ENOG4108PCX Major Facilitator BG11_4737 ENOG4108XJQ germination protein BG11_4739 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BG11_474 ENOG410874W AraC family transcriptional regulator BG11_4740 ENOG4105M59 Phosphodiesterase, mj0936 family BG11_4744 ENOG4108QCI YvbH-like oligomerisation region BG11_475 ENOG41082W1 Cupin 2, conserved barrel domain protein BG11_4751 ENOG4108IUQ atp-dependent protease BG11_4755 ENOG4105K56 Transcriptional regulator BG11_4760 ENOG4105D52 delta-aminolevulinic acid dehydratase BG11_4762 ENOG41068KH stage VI sporulation protein D BG11_4764 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BG11_4765 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BG11_4769 ENOG4105DFF Rod shape-determining protein mreb BG11_4770 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BG11_4773 ENOG4107QMS site-determining protein BG11_4776 ENOG4105C03 ribonuclease BG11_4778 ENOG4105X36 (ribosomal) protein BG11_478 ENOG4108AEY RNA polymerase sigma factor BG11_4783 ENOG4105EWM Histidine kinase BG11_4787 ENOG4105CQC Prephenate dehydratase BG11_4788 ENOG4108RPX mosc domain containing protein BG11_4791 ENOG4108IYU L-aspartate oxidase BG11_4792 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BG11_4798 ENOG4108HUF Transporter BG11_4801 ENOG41061AI Protein of unknown function (DUF2905) BG11_4804 ENOG4105VIE preprotein translocase, subunit YajC BG11_4806 ENOG4108QG2 Membrane BG11_4807 ENOG4105CKP Polysaccharide Biosynthesis Protein BG11_4809 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BG11_4810 ENOG41076HS cation diffusion facilitator family transporter BG11_4811 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BG11_4813 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BG11_4817 ENOG4105CUT histidyl-tRNA synthetase BG11_4819 ENOG4105CUZ uba thif-type nad fad binding protein BG11_482 ENOG4108JQ1 Dehydrogenase BG11_4820 ENOG4108VCI transcription factor, rsfa family BG11_4821 ENOG4105D1H recombination factor protein RarA BG11_4823 ENOG4105C3J Cysteine desulfurase BG11_4826 ENOG4105C7H Helicase, RecD TraA family BG11_4827 ENOG41060CR BG11_4830 ENOG4105C02 permease BG11_4836 ENOG4105HHA aminodeoxychorismate lyase BG11_4837 ENOG4108VQJ O-methyltransferase BG11_4838 ENOG4105XYU peptidase (U32 family) BG11_4839 ENOG4105CFP Peptidase U32 BG11_4842 ENOG4107XRG penicillin-binding protein BG11_4848 ENOG4105C28 cystathionine BG11_4849 ENOG4108EKI Dehydrogenase BG11_485 ENOG4105DVH amino acid BG11_4851 ENOG4108V5C ABC transporter BG11_4852 ENOG4105S6R Iron-hydroxamate transporter permease subunit BG11_4860 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BG11_4862 ENOG4105MIR Phenylalanine 4-monooxygenase BG11_4863 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BG11_487 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BG11_4870 ENOG4108MUZ hydrolase BG11_4872 ENOG4105G6Z alkaline phosphatase BG11_4875 ENOG4108TVJ Nitroreductase BG11_4879 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG11_488 ENOG4105C45 hydrogenase expression formation protein (HypE) BG11_4882 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BG11_4883 ENOG4105CQW ribosome biogenesis GTPase YqeH BG11_4885 ENOG410812S Rna-binding protein BG11_4887 ENOG4108WF2 Metal Dependent Phosphohydrolase BG11_4889 ENOG4105DXX methyltransferase BG11_4891 ENOG4105KQC Competence protein BG11_4892 ENOG4108UK2 deaminase BG11_4893 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BG11_4895 ENOG4105TQK DNA polymerase iii, delta' subunit BG11_49 ENOG4105C85 amino acid BG11_490 ENOG4108JPW Aminotransferase BG11_4900 ENOG4105KVH Transcriptional regulator BG11_4901 ENOG4105CSA Coproporphyrinogen iii oxidase BG11_4903 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BG11_4907 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BG11_4908 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BG11_4910 ENOG4105KTH gatB Yqey BG11_4911 ENOG41068P3 sporulation protein YqfC BG11_4913 ENOG4105C9A Phoh family BG11_4914 ENOG4105CTJ Metal Dependent Phosphohydrolase BG11_4916 ENOG4107YR5 Diacylglycerol kinase BG11_4917 ENOG4105KG3 cytidine deaminase BG11_4918 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BG11_492 ENOG4105EJQ L-serine dehydratase BG11_4923 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BG11_4924 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG11_4927 ENOG4105EGD dinuclear metal center protein, YbgI family BG11_493 ENOG4105C44 Serine transporter BG11_4932 ENOG41069ZM Protein of unknown function (DUF2624) BG11_4933 ENOG4108JYZ YitT family BG11_4934 ENOG4105FDK ABC transporter BG11_4936 ENOG4105N80 Ferric uptake regulator, Fur family BG11_4941 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BG11_4943 ENOG4107RF6 penicillin-binding protein BG11_4944 ENOG4105PWN phosphate abc transporter BG11_4945 ENOG4105C8U phosphate abc transporter BG11_4946 ENOG4105E2Z phosphate ABC transporter (Permease BG11_4947 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BG11_4948 ENOG4108UTW Plays a role in the regulation of phosphate uptake BG11_4951 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BG11_4953 ENOG4105DKQ ROK family BG11_4955 ENOG4105C5X domain protein BG11_4959 ENOG4105C28 cystathionine BG11_4960 ENOG4105C28 cystathionine BG11_4962 ENOG4105C3R Methionine synthase BG11_4963 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BG11_499 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BG11_5010 ENOG4105C0D helicase BG11_5016 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BG11_5017 ENOG4105CJ1 ABC, transporter BG11_5024 ENOG41080TC multidrug resistance protein BG11_5028 ENOG4105WZW rhodanese family BG11_5029 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BG11_5034 ENOG4107YBY Hydrolase BG11_5035 ENOG4105CBJ Metal-dependent enzyme BG11_5038 ENOG4105DC7 peptidase M24 BG11_5043 ENOG4105CD2 stage iii sporulation protein aa BG11_5044 ENOG4105KR5 Stage iii sporulation protein BG11_5045 ENOG4108CQH stage III sporulation protein AC BG11_5046 ENOG4105KQ4 Stage iii sporulation protein ad BG11_5048 ENOG410644B Stage III sporulation protein af BG11_5053 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BG11_5054 ENOG4108ZSR alkaline shock protein BG11_5059 ENOG4105CTB Polyprenyl synthetase BG11_506 ENOG4105TRI Hydrolase BG11_5061 ENOG4105DX0 Hemolysin A BG11_5063 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BG11_5064 ENOG4105S1Z Stage IV sporulation protein B BG11_5065 ENOG4107QQR Sporulation BG11_5068 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BG11_5070 ENOG4108JUB Transcriptional regulator BG11_5072 ENOG4107RDP Dehydrogenase BG11_5076 ENOG4105CPP Dehydrogenase, E1 component BG11_5077 ENOG4105C7S Dehydrogenase BG11_5079 ENOG4105E09 nadh pyrophosphatase BG11_5080 ENOG4105G7B Protein of unknown function (DUF2992) BG11_5082 ENOG4108HW3 (ABC) transporter BG11_5083 ENOG4105E5Q amino acid AbC transporter BG11_5084 ENOG4105CDA abc transporter atp-binding protein BG11_5085 ENOG4108QEG Membrane BG11_5086 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BG11_5088 ENOG4105D9U N-acetyltransferase BG11_5089 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BG11_5091 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BG11_5095 ENOG4105EJQ L-serine dehydratase BG11_5096 ENOG4105II7 pyrroline-5-carboxylate reductase BG11_5097 ENOG41069FQ Metallo-beta-lactamase superfamily BG11_5098 ENOG4108IXY short-chain dehydrogenase reductase BG11_5101 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BG11_5109 ENOG4105CGH 5'-nucleotidase BG11_5110 ENOG4105DFD Na H antiporter BG11_5112 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BG11_5114 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BG11_5115 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BG11_5116 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BG11_5117 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BG11_512 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BG11_5121 ENOG4108R6K riboflavin synthase, subunit alpha BG11_5122 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BG11_5126 ENOG4108YM7 Gcn5-related n-acetyltransferase BG11_5127 ENOG4105ETE Transcriptional regulator (LacI family BG11_5129 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BG11_5133 ENOG4105RHY Pfam:UPF0157 BG11_5135 ENOG4105CPC Aldo Keto reductase BG11_5139 ENOG4105MZ9 stage II sporulation protein m BG11_514 ENOG4106P55 Transcriptional regulator BG11_5140 ENOG4105I3K Ferric uptake regulator, Fur family BG11_5142 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BG11_5147 ENOG4105D7N magnesium and cobalt transport protein CorA BG11_5153 ENOG4105DVE abc transporter atp-binding protein BG11_5154 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BG11_5155 ENOG4105DZ1 carboxypeptidase BG11_5156 ENOG41082AN stage II sporulation protein BG11_5158 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG11_5159 ENOG4105C8J )-transporter BG11_516 ENOG4107QR9 Iron-sulfur cluster binding protein BG11_5163 ENOG41090VF Stage v sporulation protein ac BG11_5164 ENOG4105CZ3 stage V sporulation protein ad BG11_5166 ENOG4105G6R Stage v sporulation protein ae BG11_5168 ENOG4105J7I hydrolase BG11_5169 ENOG4105PTM secreted protein BG11_517 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BG11_5170 ENOG4107ZE5 PPIases accelerate the folding of proteins BG11_5177 ENOG4105CE4 GlcNAc 6-P deacetylase BG11_5179 ENOG4105FDP GntR family transcriptional regulator BG11_518 ENOG4105DJB Major Facilitator Superfamily BG11_5181 ENOG4105CID antiterminator BG11_5184 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BG11_5188 ENOG4106TD9 Diguanylate cyclase BG11_5189 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BG11_519 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BG11_5197 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BG11_52 ENOG4108SJC Membrane BG11_5201 ENOG4105DTD Dehydrogenase BG11_5209 ENOG4105CHU acetyl-coa acetyltransferase BG11_521 ENOG4105BZU Histidine kinase BG11_5218 ENOG4105CG3 alpha amylase, catalytic region BG11_5220 ENOG4107FKK extracellular solute-binding protein family 1 BG11_5222 ENOG4105EG2 ABC transporter, permease BG11_5223 ENOG4105FKQ transcriptional regulator BG11_5224 ENOG4105CHM Aminotransferase BG11_5226 ENOG4108HGU Histidine kinase BG11_5237 ENOG4105UIN BG11_5239 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BG11_524 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BG11_5242 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BG11_5243 ENOG4105EPM Diguanylate phosphodiesterase BG11_5246 ENOG4107IN1 Protein of unknown function (DUF1797) BG11_5248 ENOG4108XRC Protein of unknown function (DUF458) BG11_525 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BG11_5255 ENOG4107ZYR domain protein BG11_5256 ENOG4105CN5 Metallo-Beta-Lactamase BG11_5258 ENOG4108X4Q Hydrolase BG11_5259 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BG11_5262 ENOG4105CPP Dehydrogenase, E1 component BG11_5272 ENOG4105CXN decarboxylase BG11_5276 ENOG4105ECY inositol monophosphatase BG11_5278 ENOG4105CI3 gtp-binding protein typa BG11_5279 ENOG4105QA2 BG11_528 ENOG4105JQZ Methyltransferase BG11_5283 ENOG4108IAB Phoh family BG11_5286 ENOG4105CNI cell division protein FtsW BG11_5287 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BG11_5296 ENOG4105EKQ RNA-directed DNA polymerase BG11_5299 ENOG4106UY4 Inherit from COG: Scp-like extracellular BG11_53 ENOG4107QW4 alcohol dehydrogenase BG11_5302 ENOG4107TB6 phosphoglycerate mutase BG11_5306 ENOG4106H78 methyltransferase BG11_5307 ENOG4105H20 Sporulation integral membrane protein YlbJ BG11_5309 ENOG4105D78 K07001 NTE family protein BG11_5310 ENOG41063PX domain protein BG11_5312 ENOG4105KNH Nucleic acid-binding protein BG11_5319 ENOG41068DC Essential cell division protein (By similarity) BG11_532 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BG11_5320 ENOG4105CJN penicillin-binding protein BG11_5321 ENOG4105CJN penicillin-binding protein BG11_5322 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BG11_5325 ENOG4105CNI cell division protein FtsW BG11_5326 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BG11_5327 ENOG4105D4A Cell wall formation (By similarity) BG11_5328 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BG11_5329 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BG11_5330 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BG11_5332 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG11_5334 ENOG4105WR5 sporulation protein, YlmC YmxH family BG11_5335 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BG11_5336 ENOG4105DFA alanine racemase domain protein BG11_5338 ENOG41067XK integral membrane protein BG11_5339 ENOG4105DBK s4 domain protein BG11_534 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BG11_5344 ENOG4105C34 Pseudouridine synthase BG11_5349 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BG11_535 ENOG4108NNI Beta-lactamase domain-containing protein BG11_5360 ENOG4105DC7 peptidase M24 BG11_5361 ENOG4105F23 Fibronectin-binding protein BG11_5363 ENOG4105DSJ YicC domain protein BG11_5367 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BG11_5368 ENOG4105C25 Primosomal protein n' BG11_5369 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BG11_5371 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BG11_5373 ENOG4108ZF3 Phosphatase BG11_5374 ENOG4105D9P serine threonine protein kinase BG11_5375 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BG11_5376 ENOG4105DJV ribulose-phosphate 3-epimerase BG11_5377 ENOG4105FJ0 thiamine BG11_5379 ENOG4108ZAA Alkaline-shock protein BG11_5380 ENOG4105DP4 dak2 domain fusion protein ylov BG11_5381 ENOG4105CB5 ATP-dependent DNA helicase recG BG11_5384 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BG11_5385 ENOG4105CHR reductase BG11_5388 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BG11_5389 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BG11_5393 ENOG4105VB6 UPF0109 protein BG11_5398 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BG11_54 ENOG4105E98 transcriptional regulator DeoR family BG11_540 ENOG4105K6H D-cysteine desulfhydrase BG11_5401 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BG11_5402 ENOG4105C79 DNA protecting protein DprA BG11_5403 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BG11_5405 ENOG4108HE4 integrase family BG11_5414 ENOG4105KNE Phosphatidate cytidylyltransferase BG11_5415 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BG11_5416 ENOG4105DZP Membrane-associated zinc metalloprotease BG11_5418 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BG11_5420 ENOG4105CHV Transcription elongation factor NusA BG11_5421 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BG11_5422 ENOG4105VHM ribosomal protein BG11_5424 ENOG4105W7A Protein of unknown function (DUF503) BG11_5426 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BG11_5427 ENOG4105DTN riboflavin biosynthesis protein ribF BG11_5431 ENOG4105C1V Peptidase, M16 BG11_5433 ENOG4105E35 Dipicolinate synthase subunit A BG11_5434 ENOG4108S0H Dipicolinic acid synthetase, b subunit BG11_5435 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BG11_5437 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BG11_5439 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BG11_5441 ENOG4107QZI cell division protein FtsK BG11_5442 ENOG4105FDP GntR family transcriptional regulator BG11_5443 ENOG4105DIH basic membrane BG11_5444 ENOG4108JQ9 ABC transporter BG11_5445 ENOG4105UIB (ABC) transporter BG11_5449 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BG11_545 ENOG41062D9 Histidine kinase BG11_5450 ENOG4105XZV Protein of unknown function (DUF3243) BG11_5453 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BG11_5458 ENOG4105D48 metallophosphoesterase BG11_5459 ENOG4105MCT stage V sporulation protein S BG11_546 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG11_5460 ENOG4108IGT Dipeptidase BG11_5486 ENOG41067QW Transcriptional regulator BG11_549 ENOG4105IIP Membrane BG11_5492 ENOG4105C6E dna polymerase iii BG11_5494 ENOG4105ENA helicase BG11_5495 ENOG4105FA2 dna polymerase iii BG11_5499 ENOG4108TF4 von Willebrand factor, type A BG11_55 ENOG4105DE4 1-phosphofructokinase BG11_5500 ENOG4105KRN Transcriptional regulator, abrb family BG11_5505 ENOG4105IYK transposase BG11_5506 ENOG4105DQ6 Transposase BG11_5507 ENOG4108VXD carboxy-peptidase BG11_551 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG11_5514 ENOG4105D6J arsenicaL-resistance protein BG11_5515 ENOG41082YX Transcriptional regulator, arsr family BG11_5519 ENOG4105CKI cobalamin synthesis protein BG11_552 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BG11_5520 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BG11_5522 ENOG41067QW Transcriptional regulator BG11_5523 ENOG4105CJ3 phosphate transporter BG11_5524 ENOG41085FC arsR family transcriptional regulator BG11_5527 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BG11_5537 ENOG4105C59 p-type ATPase BG11_5538 ENOG4105VPX protein, conserved in bacteria BG11_5539 ENOG4105DSE periplasmic solute binding protein BG11_5545 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding BG11_5563 ENOG4105K63 Thioredoxin BG11_5565 ENOG4105EAB amino acid AbC transporter BG11_5566 ENOG4105E5Q amino acid AbC transporter BG11_5567 ENOG4105CDA abc transporter atp-binding protein BG11_5569 ENOG4107R16 Multicopper oxidase BG11_5570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG11_5571 ENOG4105BZU Histidine kinase BG11_5573 ENOG4108ZRV stage ii sporulation protein p BG11_5582 ENOG4105D9M gamma-glutamylcysteine synthetase BG11_5584 ENOG4105C4W S-formylglutathione hydrolase BG11_5586 ENOG4105KVH Transcriptional regulator BG11_5590 ENOG4105E1K spore germination protein BG11_5591 ENOG4108B31 Spore germination protein BG11_5594 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BG11_5595 ENOG4108QY0 Membrane BG11_5598 ENOG4105CZ3 stage V sporulation protein ad BG11_5599 ENOG41090VF Stage v sporulation protein ac BG11_56 ENOG4105DM4 PTS System BG11_5602 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BG11_5605 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BG11_5613 ENOG41086D8 Transcriptional regulator BG11_5618 ENOG4108W2Y isochorismatase BG11_5621 ENOG4108NHD germination protein BG11_5626 ENOG4107XGZ Hydrolase BG11_5628 ENOG4105YWU small acid-soluble spore protein BG11_5632 ENOG4107A6P BG11_5634 ENOG4105EKQ RNA-directed DNA polymerase BG11_5638 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BG11_5639 ENOG41089BK Glutamine amido-transferase BG11_5641 ENOG4106J6E BG11_5648 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BG11_5667 ENOG4105EKQ RNA-directed DNA polymerase BG11_567 ENOG4108YXU transcriptional regulator AsnC family BG11_568 ENOG4105CHR reductase BG11_5681 ENOG4105TQK DNA polymerase iii, delta' subunit BG11_5683 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG11_5686 ENOG4105EKQ RNA-directed DNA polymerase BG11_569 ENOG4108IG5 Transcriptional regulator BG11_5698 ENOG4105EKQ RNA-directed DNA polymerase BG11_57 ENOG41069ER domain protein BG11_570 ENOG4107P5I polyketide synthase BG11_5713 ENOG4105EKQ RNA-directed DNA polymerase BG11_5717 ENOG4105K4H Nlp p60 protein BG11_572 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG11_5724 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BG11_5729 ENOG4105DQ6 Transposase BG11_573 ENOG4105BZU Histidine kinase BG11_5747 ENOG4105D7V transposase BG11_5761 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BG11_5764 ENOG4105PKS Excinuclease abc c subunit domain protein BG11_577 ENOG41085FC arsR family transcriptional regulator BG11_5773 ENOG4107QJE Chromosome Partitioning Protein BG11_578 ENOG4105D6J arsenicaL-resistance protein BG11_5787 ENOG4108NF7 phage-type endonuclease BG11_5788 ENOG4108PNI recT protein BG11_5793 ENOG4105CDU Replicative dna helicase BG11_5813 ENOG4105QBX endodeoxyribonuclease RusA BG11_5822 ENOG4108MDF Phage Portal Protein BG11_5823 ENOG4106CGH Phage Mu protein F like protein BG11_5829 ENOG41060SN BG11_585 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BG11_586 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BG11_588 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BG11_589 ENOG4108TWJ NADH dehydrogenase subunit 5 BG11_592 ENOG4105CVP deoxyribo-dipyrimidine photolyase BG11_593 ENOG4108606 TspO/MBR family BG11_600 ENOG41090MY MarR family Transcriptional regulator BG11_605 ENOG4105CHJ isochorismatase hydrolase BG11_607 ENOG4105CH6 catalase BG11_608 ENOG4105CGH 5'-nucleotidase BG11_611 ENOG4105CSV Glutaminase BG11_615 ENOG4108Q8B Spore germination protein BG11_616 ENOG4108NHD germination protein BG11_619 ENOG4105II7 pyrroline-5-carboxylate reductase BG11_621 ENOG4105CUB amino acid BG11_622 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BG11_624 ENOG4108IMY Transcriptional regulator BG11_625 ENOG4105HDK L-asparaginase BG11_626 ENOG4108IJ0 Aspartate ammonia-lyase BG11_628 ENOG4105E2A Dehydrogenase BG11_63 ENOG4106F1P AAA ATPase, central domain protein BG11_643 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BG11_649 ENOG4105DWD nucleoside recognition domain protein BG11_65 ENOG4105EN6 Membrane BG11_653 ENOG4105FDT acyl-CoA dehydrogenase BG11_655 ENOG4108ZHR arsR family transcriptional regulator BG11_656 ENOG4108ZRV stage ii sporulation protein p BG11_657 ENOG4106N3A copper homeostasis protein cutc BG11_659 ENOG4107258 Transcriptional regulator BG11_66 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BG11_660 ENOG4105P4J Allophanate hydrolase, subunit 1 BG11_667 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BG11_669 ENOG4107RF6 penicillin-binding protein BG11_67 ENOG4105CXI aluminum resistance protein BG11_675 ENOG4105F1N DNA alkylation repair BG11_677 ENOG4108IQI permease BG11_678 ENOG4105KNA -acetyltransferase BG11_679 ENOG410635A Membrane BG11_68 ENOG4105KV4 Transcriptional regulator BG11_69 ENOG4105C5F glutamine synthetase BG11_692 ENOG4108XET gCN5-related N-acetyltransferase BG11_698 ENOG4105C19 ABC transporter BG11_700 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BG11_706 ENOG4105EFZ amidohydrolase BG11_707 ENOG4105D2S major facilitator superfamily BG11_708 ENOG4105G9B Transcriptional regulator BG11_710 ENOG4105VZJ PTS System BG11_713 ENOG4108QVC Component IIC BG11_714 ENOG4105VCP PTS System BG11_715 ENOG4105CS2 ec 3.2.1.21 BG11_716 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BG11_717 ENOG4105E39 Enoyl-CoA hydratase BG11_718 ENOG4105CHU acetyl-coa acetyltransferase BG11_719 ENOG4105CEY Amp-dependent synthetase and ligase BG11_723 ENOG4105ERH Fumarylacetoacetate hydrolase BG11_727 ENOG4105FS7 Transcriptional regulator BG11_728 ENOG4108TVJ Nitroreductase BG11_737 ENOG4105C8Y Acetylornithine aminotransferase BG11_739 ENOG4105CKK Glycosyl transferase, family 2 BG11_748 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BG11_75 ENOG4105K7K Transcriptional regulator BG11_754 ENOG41068WN BG11_756 ENOG4108WCX response regulator BG11_758 ENOG41090T1 Membrane BG11_761 ENOG4105VMP Transcriptional regulator BG11_763 ENOG4105G6Z alkaline phosphatase BG11_764 ENOG4105ECK Fatty Acid Desaturase BG11_765 ENOG4105E0Y RtcB Protein BG11_767 ENOG4107258 Transcriptional regulator BG11_773 ENOG4105II7 pyrroline-5-carboxylate reductase BG11_774 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BG11_780 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BG11_785 ENOG41061GT Aldolase BG11_787 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BG11_788 ENOG4105DKT Transcriptional regulator BG11_79 ENOG4108SVB resolvase BG11_790 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BG11_792 ENOG4105D4B ABC, transporter BG11_796 ENOG4108JUB Transcriptional regulator BG11_797 ENOG4105J5T Amp-dependent synthetase and ligase BG11_798 ENOG4105E39 Enoyl-CoA hydratase BG11_799 ENOG4105CY2 Citrate transporter BG11_8 ENOG4107QHE Choloylglycine hydrolase BG11_801 ENOG41069ER domain protein BG11_808 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BG11_81 ENOG4105CGH 5'-nucleotidase BG11_810 ENOG4105CIH Imidazole acetol-phosphate transaminase BG11_814 ENOG41082JN Transcriptional regulator BG11_815 ENOG4105EYF MMPL domain protein BG11_817 ENOG4105C5H ABC transporter BG11_818 ENOG4105E0M Sulfatase BG11_819 ENOG4108ZCF integral membrane protein BG11_821 ENOG4107VMI polysaccharide deacetylase BG11_823 ENOG4107VC0 DNA alkylation repair enzyme BG11_83 ENOG4105D5T phosphonate abc transporter BG11_833 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BG11_837 ENOG4105E09 nadh pyrophosphatase BG11_842 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BG11_843 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BG11_844 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BG11_846 ENOG4105C02 permease BG11_855 ENOG4105DVE abc transporter atp-binding protein BG11_858 ENOG4108ZMI UPF0477 protein BG11_86 ENOG4105D7V transposase BG11_861 ENOG4105CHM Aminotransferase BG11_868 ENOG41089UC methyltransferase, type 11 BG11_871 ENOG4107BMA Transglycosylase associated protein BG11_875 ENOG4106K7D Major facilitator family transporter BG11_876 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BG11_884 ENOG4105EPR degv family BG11_886 ENOG4105DPN Oligoendopeptidase f BG11_893 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG11_894 ENOG4105BZU Histidine kinase BG11_895 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BG11_90 ENOG4105BZ1 (ABC) transporter BG11_902 ENOG4105DTQ mandelate racemase muconate lactonizing BG11_905 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BG11_906 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BG11_909 ENOG4107T5V SNARE associated Golgi BG11_91 ENOG4105BZ1 (ABC) transporter BG11_915 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BG11_917 ENOG41080HI glycine oxidase BG11_918 ENOG4105CTU Proline racemase BG11_919 ENOG4105CTU Proline racemase BG11_920 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BG11_921 ENOG4105C26 Dehydrogenase BG11_922 ENOG4105BZG amino acid carrier protein BG11_925 ENOG4108M1A Chitin-binding protein BG11_934 ENOG4105C9U ATP-dependent DNA helicase RecQ BG11_938 ENOG4105EEM helicase BG11_94 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BG11_942 ENOG4108Z7F N-acetyltransferase BG11_949 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BG11_953 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BG11_957 ENOG41087PP glycosyltransferase MGT family BG11_958 ENOG4108M1A Chitin-binding protein BG11_959 ENOG41082BV acetyltransferase BG11_960 ENOG4105E66 phosphoriboisomerase A BG11_965 ENOG4108IJ7 Glycine betaine BG11_966 ENOG4107SQ8 Glycine betaine BG11_974 ENOG4105RHY Pfam:UPF0157 BG11_975 ENOG4105E1F short-chain dehydrogenase reductase BG11_977 ENOG4107RUY (E1 component), alpha subunit BG11_979 ENOG4107QKR Dehydrogenase BG11_984 ENOG4105E98 transcriptional regulator DeoR family BG11_988 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BG11_99 ENOG41067MG lrgb family BG11_992 ENOG4107Z3H Transcriptional regulator, TetR family BG11_999 ENOG4105MSI germination protein ypeb