locus-tag class description DA68_00045 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) DA68_00075 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DA68_00080 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DA68_00085 ENOG41069ER domain protein DA68_00090 ENOG4105VZ8 Transcriptional regulator DA68_00095 ENOG4107D63 DA68_00110 ENOG4105DUX Transporter DA68_00130 ENOG4105C85 amino acid DA68_00135 ENOG4105C7N Xanthine uracil vitamin C permease DA68_00150 ENOG4105MA6 gCN5-related N-acetyltransferase DA68_00175 ENOG4105BZ9 Cytochrome C oxidase, subunit I DA68_00180 ENOG4105E2S oxidase) subunit II DA68_00200 ENOG4106CAD Protein of unknown function (DUF3311) DA68_00205 ENOG4105E1V na solute symporter DA68_00220 ENOG4108NHD germination protein DA68_00225 ENOG4105CE1 Ferrous iron transport protein b DA68_00230 ENOG4105CE1 Ferrous iron transport protein b DA68_00235 ENOG4105CE1 Ferrous iron transport protein b DA68_00240 ENOG4105CVA phosphate DA68_00245 ENOG4105C8U phosphate abc transporter DA68_00250 ENOG4105E2Z phosphate ABC transporter (Permease DA68_00375 ENOG41080XQ Signal transduction protein with cbs domains DA68_00395 ENOG4105ETU transcriptional activator (TenA DA68_00405 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DA68_00415 ENOG4108VEU Thiamine monophosphate synthase DA68_00420 ENOG41080HI glycine oxidase DA68_00435 ENOG4105D06 uba thif-type nad fad binding protein DA68_00440 ENOG4105DWF phosphomethylpyrimidine kinase DA68_00490 ENOG4108INS Transcriptional regulator DA68_00515 ENOG4105C19 ABC transporter DA68_00525 ENOG4105C7N Xanthine uracil vitamin C permease DA68_00535 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DA68_00555 ENOG4105C5Y PTS System DA68_00570 ENOG4105K63 Thioredoxin DA68_00590 ENOG4108B31 Spore germination protein DA68_00610 ENOG4107Y03 Nitroreductase DA68_00615 ENOG4105ED1 spovr family DA68_00625 ENOG4108TCS Glutamyl endopeptidase DA68_00630 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DA68_00635 ENOG4105XTG Pfam:DUF156 DA68_00640 ENOG4105VFE sira family DA68_00645 ENOG4107TPS domain protein DA68_00650 ENOG4105VFE sira family DA68_00660 ENOG4105VFE sira family DA68_00670 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DA68_00675 ENOG41087NI Sulfite exporter TauE/SafE DA68_00685 ENOG4108KGH TRANSCRIPTIONal DA68_00710 ENOG4105EMD TRANSCRIPTIONal DA68_00715 ENOG4105VCP PTS System DA68_00720 ENOG4105VZJ PTS System DA68_00745 ENOG41069ER domain protein DA68_00750 ENOG4107RBB ABC transporter, permease DA68_00755 ENOG4105C19 ABC transporter DA68_00785 ENOG4105WEF catalase DA68_00820 ENOG4107T5V SNARE associated Golgi DA68_00850 ENOG4105CUB amino acid DA68_00855 ENOG4107RWR Sodium hydrogen exchanger DA68_00865 ENOG4106KNT transcriptional regulator DA68_00870 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DA68_00905 ENOG4108YXU transcriptional regulator AsnC family DA68_00910 ENOG4105CH7 arginosuccinase DA68_00915 ENOG4105UBK short-chain dehydrogenase reductase DA68_00925 ENOG4105KPY Small multidrug resistance protein DA68_00965 ENOG4105C19 ABC transporter DA68_00970 ENOG4107RBB ABC transporter, permease DA68_00975 ENOG4105C19 ABC transporter DA68_01015 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DA68_01020 ENOG4105E5W Transporter DA68_01030 ENOG4107RKG DJ-1/PfpI family DA68_01035 ENOG4105CH6 catalase DA68_01045 ENOG4105D5Q Arginine ornithine antiporter DA68_01050 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DA68_01060 ENOG4105C26 Dehydrogenase DA68_01065 ENOG4105BZ1 (ABC) transporter DA68_01070 ENOG4105BZ1 (ABC) transporter DA68_01080 ENOG4105DRP amino acid AbC transporter DA68_01085 ENOG4105CDA abc transporter atp-binding protein DA68_01100 ENOG410839P DA68_01135 ENOG4107FQX Alpha-acetolactate decarboxylase DA68_01140 ENOG4108VX5 3-methyladenine DNA glycosylase DA68_01155 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DA68_01160 ENOG4105D4P Coproporphyrinogen iii oxidase DA68_01165 ENOG4105CEY Amp-dependent synthetase and ligase DA68_01180 ENOG4105CHH sulfate transporter DA68_01205 ENOG4105CGU Enoyl-CoA hydratase DA68_01225 ENOG4105DER m42 family DA68_01270 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DA68_01275 ENOG4105C3U ABC transporter DA68_01280 ENOG4108JQ7 (ABC) transporter DA68_01340 ENOG4108IBT Inherit from COG: transposase DA68_01420 ENOG4105CSH Transporter DA68_01430 ENOG4108MRH transcriptional regulatory protein DA68_01495 ENOG4105CDU Replicative dna helicase DA68_01525 ENOG4108Z86 Glutamine amidotransferase DA68_01540 ENOG4105C0R drug resistance transporter emrb qaca subfamily DA68_01555 ENOG4105D9U N-acetyltransferase DA68_01635 ENOG4105F6J Alpha beta hydrolase fold DA68_01680 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DA68_01700 ENOG4105CMT Dihydroxyacetone kinase DA68_01710 ENOG4105CMT Dihydroxyacetone kinase DA68_01795 ENOG4105WN5 stage II sporulation protein DA68_01805 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DA68_01815 ENOG4108MJI response regulator DA68_01820 ENOG4105BZU Histidine kinase DA68_01825 ENOG4105BZU Histidine kinase DA68_01860 ENOG4107QHE Choloylglycine hydrolase DA68_01880 ENOG4107VRP DNA repair exonuclease DA68_01885 ENOG4106D4I domain protein DA68_01895 ENOG4105ED2 Beta-lactamase DA68_01930 ENOG4108MUZ hydrolase DA68_01950 ENOG4105F0F Oxalate decarboxylase DA68_01955 ENOG41067QW Transcriptional regulator DA68_01960 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DA68_01975 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DA68_02000 ENOG4105CNI cell division protein FtsW DA68_02005 ENOG4105EEM helicase DA68_02010 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DA68_02035 ENOG4105K59 histidine triad (HIT) protein DA68_02065 ENOG410905X membrane-flanked domain protein DA68_02070 ENOG4105CKV Membrane DA68_02110 ENOG410905X membrane-flanked domain protein DA68_02115 ENOG4105CKV Membrane DA68_02120 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DA68_02125 ENOG4105BZ4 penicillin-binding protein DA68_02135 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DA68_02140 ENOG4105C1Q protoporphyrinogen oxidase DA68_02165 ENOG4105NA0 Transcriptional regulator DA68_02180 ENOG4105ECB domain protein DA68_02200 ENOG4108MK9 spermidine N(1)-acetyltransferase DA68_02210 ENOG4106AXD DA68_02215 ENOG4108RQ5 Beta-lactamase domain-containing protein DA68_02220 ENOG4105DF9 Lipoate-protein, ligase DA68_02230 ENOG4105CEY Amp-dependent synthetase and ligase DA68_02310 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) DA68_02320 ENOG4105ENX hydrolase DA68_02325 ENOG4107RN3 metallophosphoesterase DA68_02330 ENOG4107TVP HD domain protein DA68_02340 ENOG4108AEY RNA polymerase sigma factor DA68_02345 ENOG41086D8 Transcriptional regulator DA68_02360 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DA68_02380 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DA68_02385 ENOG4105C8Q Methyl-accepting chemotaxis DA68_02390 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) DA68_02400 ENOG4107QP3 malate synthase g DA68_02420 ENOG4105VEQ Cold shock protein DA68_02460 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DA68_02500 ENOG4105ERH Fumarylacetoacetate hydrolase DA68_02510 ENOG4105C8Y Acetylornithine aminotransferase DA68_02525 ENOG4105CAQ asparagine synthetase DA68_02530 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DA68_02535 ENOG4105CH6 catalase DA68_02540 ENOG4105BZU Histidine kinase DA68_02550 ENOG4108VPT UPF0234 protein DA68_02555 ENOG4105QNR S1 RNA binding domain protein DA68_02560 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DA68_02565 ENOG4107AYK membrAne DA68_02570 ENOG41073B9 DA68_02580 ENOG4108KP7 hydrolase DA68_02590 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DA68_02615 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DA68_02620 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DA68_02640 ENOG4105C31 Tryptophanyl-tRNA synthetase DA68_02655 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DA68_02660 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DA68_02670 ENOG4108JQ7 (ABC) transporter DA68_02675 ENOG4105UQX Mate efflux family protein DA68_02695 ENOG4108ZCF integral membrane protein DA68_02705 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DA68_02715 ENOG4105DPN Oligoendopeptidase f DA68_02725 ENOG4108Z18 K06886 hemoglobin DA68_02730 ENOG4105MIX Adenylate cyclase DA68_02735 ENOG4106EFP UPF0738 protein DA68_02745 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DA68_02750 ENOG4105EMS pseudouridine synthase DA68_02770 ENOG4105K64 Glycosyl transferase, family 2 DA68_02790 ENOG4107TVC Glycosyl transferase, family 2 DA68_02810 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DA68_02815 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DA68_02825 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DA68_02875 ENOG4108ZMI UPF0477 protein DA68_02900 ENOG4105CK7 Sodium proline symporter DA68_02905 ENOG4105CRQ synthase (Component I) DA68_02910 ENOG4105DDQ anthranilate synthase DA68_02930 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DA68_02935 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) DA68_03000 ENOG4105C7S Dehydrogenase DA68_03010 ENOG4105VZ8 Transcriptional regulator DA68_03060 ENOG4105DZ1 carboxypeptidase DA68_03065 ENOG4105VFR signal peptidase DA68_03100 ENOG4105C26 Dehydrogenase DA68_03105 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DA68_03110 ENOG4105F38 ABC transporter, permease DA68_03115 ENOG4105D38 putrescine abc transporter DA68_03120 ENOG4107RUE extracellular solute-binding protein family 1 DA68_03130 ENOG4105EYF MMPL domain protein DA68_03140 ENOG4108YBP pseudouridine synthase DA68_03150 ENOG4105K4I Scp-like extracellular DA68_03155 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DA68_03160 ENOG4105CQB FAD linked oxidase domain protein DA68_03175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DA68_03180 ENOG4105BZU Histidine kinase DA68_03185 ENOG4105JXH GntR family transcriptional regulator DA68_03205 ENOG4106A3R peptidase DA68_03215 ENOG4108QTI )-transporter DA68_03220 ENOG4107TS3 membrane protein, TerC DA68_03225 ENOG4105CZN Potassium uptake protein DA68_03230 ENOG410681C small acid-soluble spore protein DA68_03235 ENOG4108Z7G MaoC domain protein dehydratase DA68_03255 ENOG4105CHR reductase DA68_03285 ENOG4105C4Y ABC transporter DA68_03290 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DA68_03295 ENOG4107RCV ABC transporter, permease DA68_03315 ENOG4105E98 transcriptional regulator DeoR family DA68_03330 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DA68_03340 ENOG4105PXI polysaccharide deacetylase DA68_03350 ENOG4105BZU Histidine kinase DA68_03355 ENOG41090MY MarR family Transcriptional regulator DA68_03365 ENOG4106DF1 DA68_03375 ENOG4105BZU Histidine kinase DA68_03380 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DA68_03385 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DA68_03390 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DA68_03430 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DA68_03435 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DA68_03455 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DA68_03460 ENOG4105CZV ABC transporter DA68_03470 ENOG4105CJ1 ABC, transporter DA68_03510 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DA68_03515 ENOG4105EA8 2-Nitropropane dioxygenase DA68_03520 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DA68_03530 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DA68_03555 ENOG4105NQC Flavodoxin DA68_03590 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DA68_03620 ENOG4105CZN Potassium uptake protein DA68_03625 ENOG41063Y9 DA68_03630 ENOG4105KBJ sporulation protein ytfj DA68_03650 ENOG4105CM2 brancheD-chain amino acid aminotransferase DA68_03655 ENOG4105C7K acetolactate synthase DA68_03660 ENOG4108ZP8 Acetolactate synthase small subunit DA68_03665 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DA68_03680 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DA68_03695 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DA68_03700 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DA68_03705 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DA68_03710 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DA68_03715 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DA68_03720 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DA68_03735 ENOG4107RVV histidinol phosphate phosphatase, hisj family DA68_03750 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DA68_03755 ENOG4105E0M Sulfatase DA68_03765 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DA68_03780 ENOG4107S4M Sulfate adenylate transferase DA68_03785 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DA68_03790 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DA68_03800 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DA68_03805 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DA68_03810 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DA68_03815 ENOG4105C8J )-transporter DA68_03835 ENOG4105DFD Na H antiporter DA68_03855 ENOG4105ENE Histidine kinase DA68_03860 ENOG4105WH1 Two component transcriptional regulator luxr family DA68_03880 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DA68_03905 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DA68_03925 ENOG4105CJ3 phosphate transporter DA68_03930 ENOG4107GRR phosphate transport regulator DA68_03935 ENOG4105BZ4 penicillin-binding protein DA68_03950 ENOG4105BZU Histidine kinase DA68_03955 ENOG4105I3N Conserved Protein DA68_03970 ENOG4105BZU Histidine kinase DA68_04000 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DA68_04005 ENOG4105DZ1 carboxypeptidase DA68_04010 ENOG4108JIC nucleoside recognition domain protein DA68_04020 ENOG4105FE9 pseudouridine synthase DA68_04025 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DA68_04030 ENOG4107TWT Cytochrome c biogenesis protein DA68_04035 ENOG4105CRE cytochrome C DA68_04040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DA68_04045 ENOG4105BZU Histidine kinase DA68_04050 ENOG4108WBT adenosyltransferase DA68_04065 ENOG4108SAX Membrane DA68_04080 ENOG4105C9U ATP-dependent DNA helicase RecQ DA68_04085 ENOG4105I7S Abortive infection protein DA68_04095 ENOG4107RGJ metallophosphoesterase DA68_04100 ENOG4107X2D transcriptional regulator, merr family DA68_04105 ENOG4108S6Z Negative regulator of genetic competence DA68_04130 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DA68_04135 ENOG4107RB3 L-asparaginase DA68_04150 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) DA68_04165 ENOG4105S2F DA68_04170 ENOG41065D1 DA68_04200 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DA68_04215 ENOG4105XXQ heptaprenyl diphosphate synthase component I DA68_04225 ENOG4105EAH synthase DA68_04230 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DA68_04235 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DA68_04250 ENOG41068YB TPR repeat-containing protein DA68_04265 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) DA68_04270 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DA68_04305 ENOG4108JYZ YitT family DA68_04310 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DA68_04325 ENOG4105FJR Lmbe family DA68_04330 ENOG4105CPK Glycosyl transferase (Group 1 DA68_04350 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DA68_04365 ENOG4105DVT helicase DA68_04370 ENOG4105YAC DA68_04390 ENOG4105CSM endonuclease III DA68_04400 ENOG4105BZ4 penicillin-binding protein DA68_04440 ENOG4106F55 Protein of unknown function (DUF1273) DA68_04455 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DA68_04465 ENOG4105DVT helicase DA68_04470 ENOG4105CTD carboxy-peptidase DA68_04480 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DA68_04485 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) DA68_04490 ENOG4105C2W permease DA68_04495 ENOG4105DHF Membrane DA68_04500 ENOG410890F Dynamin family DA68_04510 ENOG4108W0I acetyltransferase DA68_04520 ENOG4105KHC sulfurtransferase DA68_04575 ENOG4105HTX biosynthesis protein DA68_04605 ENOG4105CPK Glycosyl transferase (Group 1 DA68_04620 ENOG4108SZE gCN5-related N-acetyltransferase DA68_04640 ENOG41081VK Ribonuclease DA68_04705 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DA68_04715 ENOG4107RWR Sodium hydrogen exchanger DA68_04720 ENOG4105CN5 Metallo-Beta-Lactamase DA68_04725 ENOG4108Z5V transcriptional regulator, merr family DA68_04735 ENOG4105H67 Protein of unknown function (DUF421) DA68_04740 ENOG41080C8 DUF218 domain DA68_04780 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DA68_04790 ENOG4107R0U MotA TolQ exbB proton channel DA68_04795 ENOG4105ER2 Ompa motb domain protein DA68_04800 ENOG4107YTP response regulator receiver protein DA68_04805 ENOG4105CBS Chea signal transduction histidine kinase DA68_04810 ENOG4105DD5 Flagellar motor switch protein DA68_04825 ENOG4105BZU Histidine kinase DA68_04845 ENOG4105E1Q flagellar hook-associated protein DA68_04850 ENOG4105DTJ flagellar hook-associated protein DA68_04870 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DA68_04875 ENOG4108ZC9 flagellar basal-body rod protein flgc DA68_04880 ENOG41075Z6 flagellar hook-basal body complex protein fliE DA68_04885 ENOG4107U2N Flagellar M-ring protein DA68_04890 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DA68_04920 ENOG4105BZE flagellar hook protein, FlgE DA68_04935 ENOG4107R88 Chemotaxis protein (CheV) DA68_04945 ENOG4105I03 Flagellin DA68_04950 ENOG4105I03 Flagellin DA68_04955 ENOG4105E4C Lytic transglycosylase catalytic DA68_04965 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DA68_04970 ENOG4105DD5 Flagellar motor switch protein DA68_04980 ENOG4105CN7 Flagellar biosynthetic protein FliP DA68_04985 ENOG4105VS8 Flagellar biosynthetic protein fliq DA68_04995 ENOG4105D00 flagellar biosynthetic protein flhB DA68_05000 ENOG4105D7B Flagellar biosynthesis protein flha DA68_05005 ENOG4105FZW flagellar biosynthesis regulator FlhF DA68_05010 ENOG4105KTQ flagellar basal-body rod protein DA68_05015 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DA68_05050 ENOG4105KAC Antibiotic biosynthesis monooxygenase DA68_05075 ENOG4105DUM transcriptional regulator, lysR family DA68_05090 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component DA68_05120 ENOG4105CVJ phosphoglycerate mutase DA68_05130 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DA68_05150 ENOG4105CAQ asparagine synthetase DA68_05170 ENOG4105PGM cation diffusion facilitator family transporter DA68_05180 ENOG4105DRR Transcriptional regulator, GntR family DA68_05185 ENOG4108UZ3 Transporter DA68_05195 ENOG4105CKI cobalamin synthesis protein DA68_05200 ENOG4108PJD permease DA68_05215 ENOG4105DFD Na H antiporter DA68_05220 ENOG4105VUF Transcriptional regulator DA68_05230 ENOG4105C9Q fumarate hydratase class II DA68_05245 ENOG4107QJQ Mate efflux family protein DA68_05250 ENOG4105EC3 peptidase S51, dipeptidase E DA68_05270 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DA68_05300 ENOG4106BRA Membrane DA68_05335 ENOG4105CJ1 ABC, transporter DA68_05360 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DA68_05370 ENOG4108IJ0 Aspartate ammonia-lyase DA68_05375 ENOG4105C6K Malic enzyme DA68_05430 ENOG4105FVX DA68_05445 ENOG4105CSR polyphosphate kinase 2 DA68_05450 ENOG4105U3E Transcriptional regulator DA68_05460 ENOG4105DXI Major Facilitator superfamily DA68_05470 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DA68_05475 ENOG4105EU0 Major facilitator Superfamily DA68_05480 ENOG4105C6T cysteine synthase DA68_05500 ENOG4105C8J )-transporter DA68_05510 ENOG4105X5K response regulator receiver protein DA68_05515 ENOG4105H67 Protein of unknown function (DUF421) DA68_05535 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DA68_05540 ENOG4105CHR reductase DA68_05545 ENOG4105CM2 brancheD-chain amino acid aminotransferase DA68_05550 ENOG4105C7K acetolactate synthase DA68_05560 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DA68_05565 ENOG4105C01 Dihydroxy-acid dehydratase DA68_05570 ENOG4105C7B Threonine dehydratase DA68_05595 ENOG4105C6X Major Facilitator DA68_05600 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DA68_05610 ENOG4105DY9 regulatoR DA68_05615 ENOG4105CYC Transferase DA68_05620 ENOG4105K5X acetyltransferase DA68_05640 ENOG41068WN DA68_05645 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DA68_05660 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DA68_05675 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DA68_05685 ENOG4105C0X amino acid DA68_05710 ENOG4105K8R UPF0145 protein DA68_05725 ENOG4107RHR regulatoR DA68_05735 ENOG4105D9N nucleoside DA68_05740 ENOG4105KG3 cytidine deaminase DA68_05775 ENOG4107RAQ aminopeptidase DA68_05785 ENOG4107R16 Multicopper oxidase DA68_05825 ENOG4108T5E Copper resistance protein DA68_05830 ENOG4105KTB nuclear export factor GLE1 DA68_05835 ENOG4107RT3 EamA-like transporter family DA68_05840 ENOG4105GZI Transcriptional regulator DA68_05845 ENOG4108Z40 Transcriptional regulator DA68_05850 ENOG4107ZXU DSBA oxidoreductase DA68_05855 ENOG4108TVJ Nitroreductase DA68_05865 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DA68_05870 ENOG4106F5Q Membrane DA68_05875 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DA68_05885 ENOG4105CKI cobalamin synthesis protein DA68_05895 ENOG4105C0Z ABC transporter DA68_05900 ENOG4108IV0 ABC, transporter DA68_05905 ENOG4105C32 Amino acid ABC transporter (Permease) DA68_05915 ENOG4105SKE transcriptional Regulator LysR family DA68_05945 ENOG4105C4M (Ubiquinol oxidase) subunit I DA68_05950 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DA68_05955 ENOG4108JJ9 ABC, transporter DA68_05960 ENOG4108JJ8 (ABC) transporter DA68_05970 ENOG4105K64 Glycosyl transferase, family 2 DA68_05980 ENOG4108UT6 Transferase hexapeptide repeat containing protein DA68_06035 ENOG4105BZ1 (ABC) transporter DA68_06040 ENOG4105EFI regulatoR DA68_06045 ENOG4105BZU Histidine kinase DA68_06055 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DA68_06060 ENOG4108ZJ4 polysaccharide deacetylase DA68_06080 ENOG4105D6E homoserine dehydrogenase DA68_06090 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DA68_06105 ENOG4108KGH TRANSCRIPTIONal DA68_06115 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DA68_06120 ENOG4105BZU Histidine kinase DA68_06125 ENOG4107VMI polysaccharide deacetylase DA68_06135 ENOG4105KT7 mgtC SapB transporter DA68_06140 ENOG4105VRR gCN5-related N-acetyltransferase DA68_06150 ENOG4105DUU IucA IucC family protein DA68_06155 ENOG4105CEY Amp-dependent synthetase and ligase DA68_06170 ENOG4108WBH protein TIM barrel DA68_06175 ENOG4105YWU small acid-soluble spore protein DA68_06185 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DA68_06190 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DA68_06240 ENOG4105KRN Transcriptional regulator, abrb family DA68_06250 ENOG4105YVS arsR family transcriptional regulator DA68_06255 ENOG4105CPC Aldo Keto reductase DA68_06260 ENOG4107XZQ multidrug resistance protein DA68_06290 ENOG4105C8Q Methyl-accepting chemotaxis DA68_06305 ENOG4108K88 Membrane DA68_06310 ENOG4108WPJ Ferritin-like domain DA68_06325 ENOG4105DEN Luciferase family DA68_06340 ENOG4105VMI -acetyltransferase DA68_06345 ENOG4107QM2 Aldo Keto reductase DA68_06355 ENOG4105CKI cobalamin synthesis protein DA68_06365 ENOG4105DSE periplasmic solute binding protein DA68_06370 ENOG4105K4T epimerase DA68_06380 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DA68_06425 ENOG4107T5V SNARE associated Golgi DA68_06440 ENOG4108PJD permease DA68_06450 ENOG4108S4H thioesterase Superfamily protein DA68_06455 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DA68_06475 ENOG4105SXS Protein of unknown function (DUF456) DA68_06480 ENOG4105C37 (CBS) domain DA68_06500 ENOG4108Z7R Chaperone CsaA DA68_06515 ENOG4108ZRV stage ii sporulation protein p DA68_06525 ENOG4108VXD carboxy-peptidase DA68_06555 ENOG4108ZRV stage ii sporulation protein p DA68_06565 ENOG4108X4Q Hydrolase DA68_06580 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DA68_06595 ENOG41087PP glycosyltransferase MGT family DA68_06600 ENOG4108JYZ YitT family DA68_06605 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DA68_06635 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DA68_06655 ENOG4106PAW secretion accessory protein EsaA YueB DA68_06665 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) DA68_06670 ENOG4108MGT Required for secretion of EsxA and EsxB DA68_06735 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) DA68_06825 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DA68_06835 ENOG4105KBJ sporulation protein ytfj DA68_06860 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DA68_06880 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DA68_06885 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DA68_06895 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DA68_06900 ENOG4105EMN RNA polymerase sigma factor DA68_06925 ENOG4108V06 Glutathione peroxidase DA68_06940 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DA68_06960 ENOG4108IUE nitrate reductase beta subunit DA68_06965 ENOG4105R3A Nitrate reductase DA68_06975 ENOG4107V6Q Cyclic nucleotide-binding domain DA68_06980 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DA68_06985 ENOG4105D06 uba thif-type nad fad binding protein DA68_06990 ENOG4105CVM Molybdenum cofactor synthesis domain protein DA68_06995 ENOG4108ZAF Molybdopterin DA68_07000 ENOG41067WU Molybdopterin converting factor (Subunit 1) DA68_07020 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DA68_07025 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DA68_07030 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DA68_07035 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DA68_07040 ENOG4108IFG nitrite reductase, (NAD(P)H) DA68_07045 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) DA68_07080 ENOG4105MCT stage V sporulation protein S DA68_07115 ENOG4105C5H ABC transporter DA68_07130 ENOG4108UUM single-stranded DNA-binding protein DA68_07155 ENOG4107YX5 Pfam:DUF548 DA68_07160 ENOG4105C75 arginyL-tRNA synthetase DA68_07180 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DA68_07195 ENOG4105C5S asparaginyl-tRNA synthetase DA68_07200 ENOG4105C8J )-transporter DA68_07220 ENOG4107XGZ Hydrolase DA68_07225 ENOG4105CY2 Citrate transporter DA68_07245 ENOG4105KD7 acetyltransferase DA68_07255 ENOG4105VMP Transcriptional regulator DA68_07260 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DA68_07275 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 DA68_07290 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) DA68_07295 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DA68_07305 ENOG4107RVG penicillin-binding protein DA68_07310 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DA68_07315 ENOG4105E9Q Acyl-transferase DA68_07320 ENOG4108UT2 hemolysin iii DA68_07330 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DA68_07340 ENOG4108RCR degv family DA68_07350 ENOG4108KF3 Electron transport protein SCO1 SenC DA68_07355 ENOG4107Y70 Heat shock protein DA68_07360 ENOG4105CAQ asparagine synthetase DA68_07375 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DA68_07380 ENOG4108MES Periplasmic binding protein DA68_07385 ENOG4105F0I Aminotransferase DA68_07415 ENOG4105D8X mechanosensitive ion channel DA68_07420 ENOG4105BZU Histidine kinase DA68_07425 ENOG4105WH1 Two component transcriptional regulator luxr family DA68_07430 ENOG4106KNT transcriptional regulator DA68_07435 ENOG4107ZY0 Phenazine biosynthesis-like protein DA68_07455 ENOG4105CMG Carbohydrate kinase DA68_07460 ENOG4105C6Z Gluconate DA68_07470 ENOG4108YV3 Protein of unknown function (DUF2711) DA68_07500 ENOG4108IJ8 ABC transporter DA68_07505 ENOG4105E90 ABC transporter DA68_07540 ENOG4105C37 (CBS) domain DA68_07565 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DA68_07580 ENOG4107S4Y M20 DapE family protein YgeY DA68_07585 ENOG4108TSC N-acetyltransferase DA68_07590 ENOG4108JUB Transcriptional regulator DA68_07595 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DA68_07635 ENOG410841Q phosphoesterase PA-phosphatase related protein DA68_07645 ENOG4105SZ6 Thioredoxin DA68_07680 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DA68_07735 ENOG4105BZ4 penicillin-binding protein DA68_07745 ENOG4105CZM Major Facilitator DA68_07750 ENOG4105W8X HesB YadR YfhF-family protein DA68_07760 ENOG4105DXD 2-methylcitrate dehydratase DA68_07765 ENOG4105CR4 methylisocitrate lyase DA68_07770 ENOG4105C1G acyl-Coa dehydrogenase DA68_07775 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DA68_07785 ENOG4105N14 lysine exporter protein LysE YggA DA68_07790 ENOG4105E39 Enoyl-CoA hydratase DA68_07805 ENOG4107RFY SbcCD D subunit DA68_07810 ENOG4105EYH Exonuclease DA68_07830 ENOG4105FCD Major Facilitator DA68_07835 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DA68_07840 ENOG4105E4F Isochorismate synthase DA68_07845 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DA68_07850 ENOG4105WQI isochorismatase DA68_07855 ENOG4105CEY Amp-dependent synthetase and ligase DA68_07860 ENOG4105WQT MbtH domain protein DA68_07865 ENOG4105C0R drug resistance transporter emrb qaca subfamily DA68_07880 ENOG4105K70 DNA-binding protein DA68_07900 ENOG4105BZG amino acid carrier protein DA68_07920 ENOG4105FE9 pseudouridine synthase DA68_07925 ENOG4105C22 threonyL-tRNA synthetase DA68_07930 ENOG4105C19 ABC transporter DA68_07955 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DA68_07970 ENOG41081I9 integral membrane protein DA68_07980 ENOG4108Y4K DNA-binding transcriptional activator DA68_07990 ENOG4108JNI Alpha beta hydrolase DA68_08000 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DA68_08010 ENOG4105EYF MMPL domain protein DA68_08035 ENOG4105WCN acetyltransferase DA68_08060 ENOG4105C1Q protoporphyrinogen oxidase DA68_08070 ENOG41068WN DA68_08105 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DA68_08120 ENOG4105DND Transcriptional regulator DA68_08125 ENOG4108RPX mosc domain containing protein DA68_08140 ENOG4105BZ1 (ABC) transporter DA68_08145 ENOG4105BZ1 (ABC) transporter DA68_08195 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) DA68_08200 ENOG4108KPJ rna polymerase sigma factor DA68_08225 ENOG4105F32 YngK protein DA68_08250 ENOG4105RD7 BadF BadG BcrA BcrD DA68_08255 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DA68_08285 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DA68_08290 ENOG4105C1J atp-dependent rna helicase DA68_08300 ENOG4108RZE Tetr family transcriptional regulator DA68_08340 ENOG4108QY0 Membrane DA68_08375 ENOG41088CC tellurite resistance protein tehB DA68_08385 ENOG4108I0C methyltransferase DA68_08390 ENOG4107RA9 decarboxylase DA68_08395 ENOG4105K56 Transcriptional regulator DA68_08400 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DA68_08425 ENOG4105CIN aminoacyl-histidine dipeptidase DA68_08450 ENOG4105KRN Transcriptional regulator, abrb family DA68_08460 ENOG4105EJ9 Membrane DA68_08465 ENOG4105EQK -acetyltransferase DA68_08500 ENOG4105W8Z 4'-phosphopantetheinyl transferase DA68_08510 ENOG4105CHR reductase DA68_08600 ENOG4105EJQ L-serine dehydratase DA68_08605 ENOG4105C44 Serine transporter DA68_08625 ENOG4105F6S Spore photoproduct lyase DA68_08635 ENOG4105CVK Glutamate decarboxylase DA68_08650 ENOG4108NHD germination protein DA68_08655 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) DA68_08660 ENOG4105CNI cell division protein FtsW DA68_08665 ENOG4105CJW magnesium transporter DA68_08675 ENOG4107RVG penicillin-binding protein DA68_08690 ENOG4107RF6 penicillin-binding protein DA68_08695 ENOG4107RF6 penicillin-binding protein DA68_08705 ENOG4105DIN metallophosphoesterase DA68_08715 ENOG4105CJ1 ABC, transporter DA68_08725 ENOG4107Z3H Transcriptional regulator, TetR family DA68_08740 ENOG4105C1G acyl-Coa dehydrogenase DA68_08745 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DA68_08750 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DA68_08755 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DA68_08760 ENOG4105E39 Enoyl-CoA hydratase DA68_08765 ENOG4107QX3 carboxylase DA68_08770 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DA68_08790 ENOG4105DBI uridine monophosphokinase DA68_08800 ENOG4105DZ1 carboxypeptidase DA68_08815 ENOG4105T9C HD domain DA68_08825 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DA68_08845 ENOG41075H3 AraC family transcriptional regulator DA68_08875 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DA68_08885 ENOG4107Y80 Major Facilitator superfamily DA68_08950 ENOG4108V4B ThiJ pfpI DA68_08965 ENOG410900G Protein of unknown function (DUF421) DA68_08970 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DA68_08980 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DA68_08985 ENOG4105DK7 lysyl-tRNA synthetase DA68_09045 ENOG4105D6E homoserine dehydrogenase DA68_09055 ENOG4105CPF Cell wall formation (By similarity) DA68_09060 ENOG4105ETU transcriptional activator (TenA DA68_09155 ENOG410667J hydrolase DA68_09160 ENOG4105BZU Histidine kinase DA68_09165 ENOG4107RF6 penicillin-binding protein DA68_09190 ENOG4108JJB ABC transporter DA68_09200 ENOG4108HGU Histidine kinase DA68_09240 ENOG4105CB2 alcohol dehydrogenase DA68_09245 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DA68_09250 ENOG4105CJN penicillin-binding protein DA68_09295 ENOG4105F27 Major Facilitator DA68_09300 ENOG4107Y80 Major Facilitator superfamily DA68_09315 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DA68_09340 ENOG4107Y9U Membrane DA68_09360 ENOG4105EGD dinuclear metal center protein, YbgI family DA68_09385 ENOG4105FCD Major Facilitator DA68_09400 ENOG4105E09 nadh pyrophosphatase DA68_09405 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DA68_09425 ENOG4108XI2 Domain of unknown function (DUF1963) DA68_09450 ENOG4108NRW Phospholipase, patatin family DA68_09455 ENOG4105KWG Pfam:DUF1696 DA68_09465 ENOG4108YYS metal-dependent hydrolase (By similarity) DA68_09480 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DA68_09490 ENOG4105PKS Excinuclease abc c subunit domain protein DA68_09530 ENOG4107VFR oxidoreductase DA68_09555 ENOG4105U0R haloacid dehalogenase-like hydrolase DA68_09560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DA68_09565 ENOG4105BZU Histidine kinase DA68_09585 ENOG4107WD8 ABC transporter, permease DA68_09600 ENOG4105DY8 decarboxylase DA68_09615 ENOG4108IUM Glycogen debranching enzyme DA68_09625 ENOG4105CGH 5'-nucleotidase DA68_09645 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DA68_09650 ENOG4105FDR Membrane DA68_09655 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DA68_09705 ENOG4105MSI germination protein ypeb DA68_09735 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) DA68_09740 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) DA68_09745 ENOG4107Z3H Transcriptional regulator, TetR family DA68_09775 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DA68_09790 ENOG4105E98 transcriptional regulator DeoR family DA68_09805 ENOG41062ES Transcriptional regulator DA68_09825 ENOG4107QKR Dehydrogenase DA68_09835 ENOG4107RUY (E1 component), alpha subunit DA68_09845 ENOG4105E1F short-chain dehydrogenase reductase DA68_09850 ENOG4105RHY Pfam:UPF0157 DA68_09880 ENOG4107SQ8 Glycine betaine DA68_09885 ENOG4108IJ7 Glycine betaine DA68_09910 ENOG4105E66 phosphoriboisomerase A DA68_09915 ENOG41082BV acetyltransferase DA68_09920 ENOG4108M1A Chitin-binding protein DA68_09925 ENOG41087PP glycosyltransferase MGT family DA68_09935 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DA68_09950 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DA68_09955 ENOG4105MSB protein, conserved in bacteria DA68_09980 ENOG4108Z7F N-acetyltransferase DA68_10000 ENOG4105EEM helicase DA68_10015 ENOG4105C9U ATP-dependent DNA helicase RecQ DA68_10055 ENOG4108M1A Chitin-binding protein DA68_10070 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DA68_10080 ENOG4105BZG amino acid carrier protein DA68_10085 ENOG4105C26 Dehydrogenase DA68_10090 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DA68_10095 ENOG4105CTU Proline racemase DA68_10100 ENOG4105CTU Proline racemase DA68_10105 ENOG41080HI glycine oxidase DA68_10115 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein DA68_10150 ENOG4105DCI Phosphohydrolase DA68_10155 ENOG4107T5V SNARE associated Golgi DA68_10165 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DA68_10185 ENOG4105DTQ mandelate racemase muconate lactonizing DA68_10200 ENOG4105CPC Aldo Keto reductase DA68_10235 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) DA68_10240 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DA68_10245 ENOG4105BZU Histidine kinase DA68_10250 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DA68_10275 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 DA68_10290 ENOG4105DPN Oligoendopeptidase f DA68_10295 ENOG4105EPR degv family DA68_10355 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DA68_10360 ENOG4106K7D Major facilitator family transporter DA68_10380 ENOG4107BMA Transglycosylase associated protein DA68_10395 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DA68_10430 ENOG4105CHM Aminotransferase DA68_10445 ENOG4108ZMI UPF0477 protein DA68_10460 ENOG4105DVE abc transporter atp-binding protein DA68_10505 ENOG4105C02 permease DA68_10515 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DA68_10520 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DA68_10525 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DA68_10530 ENOG4105D7T ABC transporter DA68_10555 ENOG4108AQF aminoglycoside N(3)-acetyltransferase DA68_10595 ENOG4107VC0 DNA alkylation repair enzyme DA68_10600 ENOG4105C6T cysteine synthase DA68_10605 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DA68_10610 ENOG4107VMI polysaccharide deacetylase DA68_10615 ENOG4108ZCF integral membrane protein DA68_10620 ENOG4105E0M Sulfatase DA68_10625 ENOG4105C5H ABC transporter DA68_10630 ENOG4105EYF MMPL domain protein DA68_10635 ENOG41082JN Transcriptional regulator DA68_10660 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DA68_10665 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DA68_10705 ENOG41069ER domain protein DA68_10715 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DA68_10720 ENOG4105DNP FAD linked oxidase domain protein DA68_10745 ENOG4105D4B ABC, transporter DA68_10750 ENOG4105F5R ABC transporter DA68_10755 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane DA68_10765 ENOG4105DKT Transcriptional regulator DA68_10770 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) DA68_10780 ENOG41061GT Aldolase DA68_10785 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DA68_10820 ENOG4105II7 pyrroline-5-carboxylate reductase DA68_10830 ENOG4107258 Transcriptional regulator DA68_10845 ENOG4105ECK Fatty Acid Desaturase DA68_10855 ENOG4107RBI VanW family DA68_10860 ENOG4105G6Z alkaline phosphatase DA68_10870 ENOG4105VMP Transcriptional regulator DA68_10895 ENOG41068WN DA68_10920 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DA68_10945 ENOG4105CKK Glycosyl transferase, family 2 DA68_10975 ENOG4105C8Y Acetylornithine aminotransferase DA68_11020 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DA68_11055 ENOG4108IBT Inherit from COG: transposase DA68_11075 ENOG4108TVJ Nitroreductase DA68_11080 ENOG4105FS7 Transcriptional regulator DA68_11095 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DA68_11100 ENOG4105WEC Molybdate metabolism regulator DA68_11110 ENOG4105CMR udp-glucose 4-epimerase DA68_11115 ENOG4105C19 ABC transporter DA68_11140 ENOG4108DMH HTH_ARAC DA68_11145 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DA68_11150 ENOG4108XET gCN5-related N-acetyltransferase DA68_11160 ENOG4105E09 nadh pyrophosphatase DA68_11165 ENOG4108PCN EamA-like transporter family DA68_11175 ENOG4107XJU UPF0178 protein DA68_11215 ENOG410635A Membrane DA68_11225 ENOG4108IQI permease DA68_11235 ENOG4105F1N DNA alkylation repair DA68_11270 ENOG4107RF6 penicillin-binding protein DA68_11280 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DA68_11310 ENOG4105P4J Allophanate hydrolase, subunit 1 DA68_11315 ENOG4107258 Transcriptional regulator DA68_11325 ENOG4106N3A copper homeostasis protein cutc DA68_11330 ENOG4108ZHR arsR family transcriptional regulator DA68_11340 ENOG4105FDT acyl-CoA dehydrogenase DA68_11355 ENOG4105DWD nucleoside recognition domain protein DA68_11400 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DA68_11430 ENOG4105E2A Dehydrogenase DA68_11440 ENOG4108IJ0 Aspartate ammonia-lyase DA68_11445 ENOG4105HDK L-asparaginase DA68_11450 ENOG4108IMY Transcriptional regulator DA68_11460 ENOG4108B31 Spore germination protein DA68_11470 ENOG4105BZU Histidine kinase DA68_11495 ENOG41075H3 AraC family transcriptional regulator DA68_11505 ENOG4105YWU small acid-soluble spore protein DA68_11510 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DA68_11515 ENOG4105CUB amino acid DA68_11520 ENOG4105II7 pyrroline-5-carboxylate reductase DA68_11525 ENOG4108NHD germination protein DA68_11530 ENOG4108Q8B Spore germination protein DA68_11550 ENOG4105CSV Glutaminase DA68_11575 ENOG4105CGH 5'-nucleotidase DA68_11585 ENOG4105CHJ isochorismatase hydrolase DA68_11610 ENOG41090MY MarR family Transcriptional regulator DA68_11615 ENOG4105EQ0 Major Facilitator superfamily DA68_11660 ENOG4105F6J Alpha beta hydrolase fold DA68_11675 ENOG4108606 TspO/MBR family DA68_11680 ENOG4105CVP deoxyribo-dipyrimidine photolyase DA68_11725 ENOG4105F2M alpha beta hydrolase fold-3 domain protein DA68_11740 ENOG4108TWJ NADH dehydrogenase subunit 5 DA68_11745 ENOG4105GPN Uncharacterized conserved protein (DUF2294) DA68_11750 ENOG4105C0R drug resistance transporter emrb qaca subfamily DA68_11770 ENOG4107VMI polysaccharide deacetylase DA68_11775 ENOG4105KY5 gCN5-related N-acetyltransferase DA68_11780 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DA68_11785 ENOG4105ECQ AraC Family Transcriptional Regulator DA68_11805 ENOG4105D6J arsenicaL-resistance protein DA68_11810 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase DA68_11815 ENOG41085FC arsR family transcriptional regulator DA68_11830 ENOG4107P5I polyketide synthase DA68_11835 ENOG4108IG5 Transcriptional regulator DA68_11865 ENOG4105N0V mono-oxygenase ydhR DA68_11925 ENOG4105C19 ABC transporter DA68_11955 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DA68_11960 ENOG4105C0R drug resistance transporter emrb qaca subfamily DA68_11975 ENOG4105K6H D-cysteine desulfhydrase DA68_11990 ENOG4105JQZ Methyltransferase DA68_12010 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) DA68_12025 ENOG4105BZU Histidine kinase DA68_12035 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DA68_12065 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DA68_12100 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DA68_12215 ENOG4108VXD carboxy-peptidase DA68_12220 ENOG4105PNM synthesis protein DA68_12230 ENOG4108ISG Major Facilitator DA68_12245 ENOG4107MII Sugar-specific transcriptional regulator TrmB DA68_12250 ENOG4105CZM Major Facilitator DA68_12260 ENOG4105CRW Short chain fatty acid transporter DA68_12270 ENOG4105DYS nad(p)h dehydrogenase (quinone) DA68_12305 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DA68_12330 ENOG4108K8S endonuclease I DA68_12350 ENOG4108Z66 YbaK ebsC protein DA68_12355 ENOG4105CUT histidyl-tRNA synthetase DA68_12370 ENOG4105KVH Transcriptional regulator DA68_12375 ENOG4108RCM Nitroreductase DA68_12405 ENOG4108PSK reductase DA68_12415 ENOG4105CJ1 ABC, transporter DA68_12470 ENOG4105C31 Tryptophanyl-tRNA synthetase DA68_12475 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DA68_12535 ENOG4105C37 (CBS) domain DA68_12550 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DA68_12555 ENOG4105FAW cDP-glucose 4,6-dehydratase DA68_12585 ENOG4105DDN Pentapeptide repeat-containing protein DA68_12590 ENOG4105XDF Protein of unknown function (DUF1272) DA68_12595 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DA68_12600 ENOG4105CMG Carbohydrate kinase DA68_12605 ENOG4105C6Z Gluconate DA68_12610 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DA68_12620 ENOG4105CV1 Transketolase (EC 2.2.1.1) DA68_12625 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DA68_12645 ENOG4105C8Q Methyl-accepting chemotaxis DA68_12650 ENOG4108UX3 '-nucleotidase DA68_12655 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DA68_12660 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) DA68_12665 ENOG4105KVH Transcriptional regulator DA68_12685 ENOG4105C44 Serine transporter DA68_12710 ENOG4108TZY GntR Family Transcriptional Regulator DA68_12715 ENOG4105D9R oxidoreductase DA68_12755 ENOG4105JAB phenazine biosynthesis protein, phzf family DA68_12760 ENOG4105KNA -acetyltransferase DA68_12770 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DA68_12775 ENOG4105KVH Transcriptional regulator DA68_12785 ENOG4108ZJ4 polysaccharide deacetylase DA68_12855 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) DA68_12865 ENOG4107YXZ hydrolase, family 25 DA68_12890 ENOG4105H3G oxidoreductase DA68_12955 ENOG4108TN2 lmbE family DA68_12965 ENOG4107R3E Citrate transporter DA68_12980 ENOG4108MES Periplasmic binding protein DA68_12985 ENOG4105EHG Permease protein DA68_12990 ENOG4105DQ5 transport system permease protein DA68_12995 ENOG4105NX3 Membrane DA68_13015 ENOG4107CUJ Protein of unknown function (DUF2690) DA68_13025 ENOG4107V2S Transcriptional regulator DA68_13055 ENOG4105C98 muts2 protein DA68_13065 ENOG4105E5K Alpha-amylase DA68_13070 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DA68_13075 ENOG4105DPN Oligoendopeptidase f DA68_13105 ENOG4108A04 Beta-lactamase DA68_13130 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DA68_13140 ENOG41082BM Transcriptional regulator, arsr family DA68_13145 ENOG4105CIS alcohol dehydrogenase DA68_13165 ENOG4105C09 Bile acid DA68_13170 ENOG4105CQB FAD linked oxidase domain protein DA68_13195 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DA68_13205 ENOG4107TPS domain protein DA68_13210 ENOG4105CEP NADH dehydrogenase DA68_13220 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C DA68_13225 ENOG4108M1A Chitin-binding protein DA68_13235 ENOG4105E1K spore germination protein DA68_13255 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DA68_13265 ENOG4108IAJ Nad-dependent epimerase dehydratase DA68_13270 ENOG4105FAW cDP-glucose 4,6-dehydratase DA68_13615 ENOG4105GR3 Histidine kinase DA68_13620 ENOG4105BZU Histidine kinase DA68_13630 ENOG41069ER domain protein DA68_13680 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DA68_13700 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) DA68_13735 ENOG4105BZU Histidine kinase DA68_13740 ENOG4105C5H ABC transporter DA68_13750 ENOG4107DUR UPF0457 protein DA68_13770 ENOG4105BZU Histidine kinase DA68_13780 ENOG4105KT7 mgtC SapB transporter DA68_13790 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DA68_13795 ENOG41073R8 VanW family DA68_13805 ENOG4108R1P DA68_13820 ENOG4105VEQ Cold shock protein DA68_13840 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DA68_13860 ENOG410904N short-chain dehydrogenase reductase DA68_13870 ENOG4106IQC argininosuccinate lyase DA68_13885 ENOG4108IA2 Sodium pantothenate symporter DA68_13895 ENOG4105C26 Dehydrogenase DA68_13900 ENOG4105CHR reductase DA68_13910 ENOG4105EWU Squalene--hopene cyclase DA68_13920 ENOG4105FR1 rard protein DA68_13925 ENOG410696E Membrane DA68_13940 ENOG4105D1F ATP-binding protein DA68_13950 ENOG4108ZAF Molybdopterin DA68_13955 ENOG4105CVM Molybdenum cofactor synthesis domain protein DA68_13960 ENOG4105D06 uba thif-type nad fad binding protein DA68_13965 ENOG4105TMB Formate nitrite transporter DA68_13975 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DA68_13980 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DA68_13990 ENOG4108JB9 formate dehydrogenase DA68_13995 ENOG4105E1K spore germination protein DA68_14060 ENOG4107QJT sodium dicarboxylate symporter DA68_14065 ENOG4108KGH TRANSCRIPTIONal DA68_14075 ENOG4105EMN RNA polymerase sigma factor DA68_14085 ENOG4105CIG ABC transporter DA68_14095 ENOG4105D9R oxidoreductase DA68_14105 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DA68_14110 ENOG4105K4P CoA-binding domain protein DA68_14115 ENOG4105C0H protease DA68_14120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DA68_14130 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DA68_14135 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DA68_14140 ENOG4105W8X HesB YadR YfhF-family protein DA68_14170 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DA68_14175 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DA68_14185 ENOG4105BZ1 (ABC) transporter DA68_14190 ENOG4108I0Z Aconitate hydratase DA68_14220 ENOG4105E5W Transporter DA68_14230 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DA68_14260 ENOG4107F3J Amp-dependent synthetase and ligase DA68_14265 ENOG4107ZYJ bioY protein DA68_14270 ENOG4105CEY Amp-dependent synthetase and ligase DA68_14275 ENOG4108IMY Transcriptional regulator DA68_14315 ENOG4107AYK membrAne DA68_14325 ENOG4105BZU Histidine kinase DA68_14330 ENOG4105FBA Phospholipase Carboxylesterase DA68_14335 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DA68_14340 ENOG4105CK7 Sodium proline symporter DA68_14350 ENOG4105CBC glutamate synthase DA68_14355 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DA68_14360 ENOG4108VJ1 Transcriptional regulator (CarD family DA68_14365 ENOG4108903 Formimidoylglutamase DA68_14375 ENOG4105CGP Urocanate hydratase DA68_14390 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) DA68_14420 ENOG4107QIV Cytochrome c biogenesis protein DA68_14430 ENOG4105CH2 amidohydrolase DA68_14440 ENOG4105CJ1 ABC, transporter DA68_14455 ENOG4107RSM transcriptional regulator DA68_14460 ENOG4105VAW lrga family DA68_14465 ENOG41067MG lrgb family DA68_14505 ENOG4105BZ1 (ABC) transporter DA68_14510 ENOG4105BZ1 (ABC) transporter DA68_14545 ENOG4108HW3 (ABC) transporter DA68_14550 ENOG4105CGH 5'-nucleotidase DA68_14560 ENOG4108SVB resolvase DA68_14580 ENOG4105K7K Transcriptional regulator DA68_14585 ENOG4105C5F glutamine synthetase DA68_14590 ENOG4105KV4 Transcriptional regulator DA68_14595 ENOG4105CXI aluminum resistance protein DA68_14600 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DA68_14605 ENOG4105EN6 Membrane DA68_14615 ENOG4106F1P AAA ATPase, central domain protein DA68_14645 ENOG41069ER domain protein DA68_14650 ENOG4105DM4 PTS System DA68_14655 ENOG4105DE4 1-phosphofructokinase DA68_14660 ENOG4105E98 transcriptional regulator DeoR family DA68_14665 ENOG4107QW4 alcohol dehydrogenase DA68_14670 ENOG4108SJC Membrane DA68_14685 ENOG4105C85 amino acid DA68_14700 ENOG4105TMB Formate nitrite transporter DA68_14705 ENOG4105K70 DNA-binding protein DA68_14715 ENOG4105C59 p-type ATPase DA68_14720 ENOG410681U heavy metal transport detoxification protein DA68_14725 ENOG4105VPX protein, conserved in bacteria DA68_14730 ENOG4105D01 (LipO)protein DA68_14740 ENOG4105NIV Esterase DA68_14745 ENOG4105E0A ABC, transporter DA68_14770 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DA68_14775 ENOG4105D03 DNA-3-methyladenine glycosylase II DA68_14805 ENOG4105BZU Histidine kinase DA68_14825 ENOG4105C5E polysaccharide biosynthesis protein DA68_14840 ENOG41067MG lrgb family DA68_14860 ENOG4108S3Y transcriptional regulator DA68_14865 ENOG4105CS2 ec 3.2.1.21 DA68_14880 ENOG4105F0V Cell wall hydrolase DA68_14890 ENOG4105E0M Sulfatase DA68_14895 ENOG410890F Dynamin family DA68_14930 ENOG4105DQU oxidoreductase, subunit beta DA68_14935 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DA68_14940 ENOG4108IGT Dipeptidase DA68_14945 ENOG4105MCT stage V sporulation protein S DA68_14950 ENOG4105D48 metallophosphoesterase DA68_14975 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DA68_14990 ENOG4105XZV Protein of unknown function (DUF3243) DA68_14995 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DA68_15015 ENOG4105UIB (ABC) transporter DA68_15020 ENOG4108JQ9 ABC transporter DA68_15025 ENOG4105DIH basic membrane DA68_15030 ENOG4105FDP GntR family transcriptional regulator DA68_15035 ENOG4105CNU cell division protein FtsK DA68_15045 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DA68_15055 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DA68_15065 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DA68_15070 ENOG4108S0H Dipicolinic acid synthetase, b subunit DA68_15075 ENOG4105E35 Dipicolinate synthase subunit A DA68_15085 ENOG4105C1V Peptidase, M16 DA68_15105 ENOG4105DTN riboflavin biosynthesis protein ribF DA68_15120 ENOG4105W7A Protein of unknown function (DUF503) DA68_15130 ENOG4105VHM ribosomal protein DA68_15135 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DA68_15140 ENOG4105CHV Transcription elongation factor NusA DA68_15150 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DA68_15160 ENOG4105DZP Membrane-associated zinc metalloprotease DA68_15165 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DA68_15170 ENOG4105KNE Phosphatidate cytidylyltransferase DA68_15175 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DA68_15185 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DA68_15215 ENOG4108HE4 integrase family DA68_15225 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DA68_15230 ENOG4105C79 DNA protecting protein DprA DA68_15235 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DA68_15250 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DA68_15275 ENOG4105VB6 UPF0109 protein DA68_15295 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DA68_15300 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DA68_15315 ENOG4105CHR reductase DA68_15320 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DA68_15335 ENOG4105CB5 ATP-dependent DNA helicase recG DA68_15340 ENOG4105DP4 dak2 domain fusion protein ylov DA68_15345 ENOG4108ZAA Alkaline-shock protein DA68_15360 ENOG4105FJ0 thiamine DA68_15365 ENOG4105DJV ribulose-phosphate 3-epimerase DA68_15370 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DA68_15375 ENOG4105D9P serine threonine protein kinase DA68_15380 ENOG4108ZF3 Phosphatase DA68_15390 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DA68_15405 ENOG4105C25 Primosomal protein n' DA68_15410 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DA68_15430 ENOG4105DSJ YicC domain protein DA68_15440 ENOG4105F23 Fibronectin-binding protein DA68_15450 ENOG4105DC7 peptidase M24 DA68_15495 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DA68_15500 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DA68_15530 ENOG4105C34 Pseudouridine synthase DA68_15545 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DA68_15555 ENOG4105DBK s4 domain protein DA68_15560 ENOG41067XK integral membrane protein DA68_15570 ENOG4105DFA alanine racemase domain protein DA68_15575 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DA68_15580 ENOG4105WR5 sporulation protein, YlmC YmxH family DA68_15590 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DA68_15600 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DA68_15605 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DA68_15615 ENOG4105D4A Cell wall formation (By similarity) DA68_15620 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DA68_15625 ENOG4105CNI cell division protein FtsW DA68_15640 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DA68_15645 ENOG4105CJN penicillin-binding protein DA68_15650 ENOG4105CJN penicillin-binding protein DA68_15665 ENOG41074B2 UPF0747 protein DA68_15690 ENOG4105KNH Nucleic acid-binding protein DA68_15700 ENOG41063PX domain protein DA68_15705 ENOG4105D78 K07001 NTE family protein DA68_15710 ENOG4105H20 Sporulation integral membrane protein YlbJ DA68_15720 ENOG4106H78 methyltransferase DA68_15740 ENOG4107TB6 phosphoglycerate mutase DA68_15755 ENOG4106UY4 Inherit from COG: Scp-like extracellular DA68_15805 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DA68_15810 ENOG4105CNI cell division protein FtsW DA68_15825 ENOG4108IAB Phoh family DA68_15845 ENOG4105QA2 DA68_15850 ENOG4105CI3 gtp-binding protein typa DA68_15860 ENOG4105ECY inositol monophosphatase DA68_15880 ENOG4105CXN decarboxylase DA68_15930 ENOG4105CPP Dehydrogenase, E1 component DA68_15945 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DA68_15950 ENOG4108X4Q Hydrolase DA68_15960 ENOG4105CN5 Metallo-Beta-Lactamase DA68_15965 ENOG4107ZYR domain protein DA68_16000 ENOG4108XRC Protein of unknown function (DUF458) DA68_16010 ENOG4107IN1 Protein of unknown function (DUF1797) DA68_16025 ENOG4105EPM Diguanylate phosphodiesterase DA68_16030 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DA68_16045 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) DA68_16055 ENOG4105UIN DA68_16090 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DA68_16110 ENOG4108HGU Histidine kinase DA68_16120 ENOG4105CHM Aminotransferase DA68_16125 ENOG4105FKQ transcriptional regulator DA68_16130 ENOG4105EG2 ABC transporter, permease DA68_16140 ENOG4107FKK extracellular solute-binding protein family 1 DA68_16150 ENOG4105CG3 alpha amylase, catalytic region DA68_16195 ENOG4105CHU acetyl-coa acetyltransferase DA68_16225 ENOG4105K7K Transcriptional regulator DA68_16230 ENOG4105DTD Dehydrogenase DA68_16250 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DA68_16275 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) DA68_16290 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DA68_16300 ENOG4105BZU Histidine kinase DA68_16320 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DA68_16335 ENOG4105CID antiterminator DA68_16345 ENOG4105FDP GntR family transcriptional regulator DA68_16355 ENOG4105CE4 GlcNAc 6-P deacetylase DA68_16390 ENOG4107ZE5 PPIases accelerate the folding of proteins DA68_16395 ENOG4105PTM secreted protein DA68_16400 ENOG4105J7I hydrolase DA68_16410 ENOG4105G6R Stage v sporulation protein ae DA68_16420 ENOG4105CZ3 stage V sporulation protein ad DA68_16425 ENOG41090VF Stage v sporulation protein ac DA68_16445 ENOG4105C8J )-transporter DA68_16450 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DA68_16460 ENOG41082AN stage II sporulation protein DA68_16465 ENOG4105DZ1 carboxypeptidase DA68_16470 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DA68_16475 ENOG4105DVE abc transporter atp-binding protein DA68_16510 ENOG4105D7N magnesium and cobalt transport protein CorA DA68_16535 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DA68_16545 ENOG4105I3K Ferric uptake regulator, Fur family DA68_16550 ENOG4105MZ9 stage II sporulation protein m DA68_16570 ENOG4105CPC Aldo Keto reductase DA68_16580 ENOG4105RHY Pfam:UPF0157 DA68_16600 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DA68_16610 ENOG4105ETE Transcriptional regulator (LacI family DA68_16615 ENOG4108YM7 Gcn5-related n-acetyltransferase DA68_16635 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DA68_16640 ENOG4108R6K riboflavin synthase, subunit alpha DA68_16665 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DA68_16670 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DA68_16685 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DA68_16695 ENOG4105DFD Na H antiporter DA68_16700 ENOG4105CGH 5'-nucleotidase DA68_16725 ENOG4105DBV ornithine carbamoyltransferase DA68_16740 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DA68_16755 ENOG4108IXY short-chain dehydrogenase reductase DA68_16760 ENOG41069FQ Metallo-beta-lactamase superfamily DA68_16765 ENOG4105II7 pyrroline-5-carboxylate reductase DA68_16770 ENOG4105EJQ L-serine dehydratase DA68_16780 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DA68_16795 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic DA68_16805 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DA68_16810 ENOG4105D9U N-acetyltransferase DA68_16820 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DA68_16825 ENOG4108QEG Membrane DA68_16830 ENOG4105CDA abc transporter atp-binding protein DA68_16835 ENOG4105E5Q amino acid AbC transporter DA68_16840 ENOG4108HW3 (ABC) transporter DA68_16850 ENOG4105G7B Protein of unknown function (DUF2992) DA68_16860 ENOG4108QY0 Membrane DA68_16870 ENOG4105C7S Dehydrogenase DA68_16875 ENOG4105CPP Dehydrogenase, E1 component DA68_16895 ENOG4107RDP Dehydrogenase DA68_16905 ENOG4108JUB Transcriptional regulator DA68_16915 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DA68_16930 ENOG4107QQR Sporulation DA68_16935 ENOG4105S1Z Stage IV sporulation protein B DA68_16940 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DA68_16945 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) DA68_16950 ENOG4105DX0 Hemolysin A DA68_16960 ENOG4105CTB Polyprenyl synthetase DA68_16975 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DA68_16985 ENOG4108ZSR alkaline shock protein DA68_16990 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DA68_17010 ENOG410644B Stage III sporulation protein af DA68_17020 ENOG4105KQ4 Stage iii sporulation protein ad DA68_17025 ENOG4108CQH stage III sporulation protein AC DA68_17030 ENOG4105KR5 Stage iii sporulation protein DA68_17035 ENOG4105CD2 stage iii sporulation protein aa DA68_17060 ENOG4105DC7 peptidase M24 DA68_17065 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DA68_17075 ENOG4105CBJ Metal-dependent enzyme DA68_17085 ENOG4107YBY Hydrolase DA68_17110 ENOG41082GG biotin lipoate A B protein ligase DA68_17115 ENOG4105WZW rhodanese family DA68_17140 ENOG41080TC multidrug resistance protein DA68_17170 ENOG4105CJ1 ABC, transporter DA68_17175 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DA68_17205 ENOG4105C0D helicase DA68_17290 ENOG4107R6U sodium dicarboxylate symporter DA68_17325 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DA68_17330 ENOG4105C3R Methionine synthase DA68_17340 ENOG4105C28 cystathionine DA68_17345 ENOG4105C28 cystathionine DA68_17365 ENOG4105C5X domain protein DA68_17370 ENOG4105DKQ ROK family DA68_17380 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DA68_17395 ENOG4108UTW Plays a role in the regulation of phosphate uptake DA68_17400 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DA68_17405 ENOG4105C8U phosphate abc transporter DA68_17410 ENOG4105C8U phosphate abc transporter DA68_17415 ENOG4105EXS phosphate abc transporter DA68_17420 ENOG4107RF6 penicillin-binding protein DA68_17430 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DA68_17455 ENOG4105N80 Ferric uptake regulator, Fur family DA68_17465 ENOG4105FDK ABC transporter DA68_17470 ENOG4108JYZ YitT family DA68_17475 ENOG41069ZM Protein of unknown function (DUF2624) DA68_17500 ENOG4105EGD dinuclear metal center protein, YbgI family DA68_17515 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DA68_17520 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DA68_17545 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DA68_17550 ENOG4105KG3 cytidine deaminase DA68_17555 ENOG4107YR5 Diacylglycerol kinase DA68_17565 ENOG4105CTJ Metal Dependent Phosphohydrolase DA68_17570 ENOG4105C9A Phoh family DA68_17580 ENOG41068P3 sporulation protein YqfC DA68_17585 ENOG4105KTH gatB Yqey DA68_17595 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DA68_17600 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DA68_17630 ENOG4105CSA Coproporphyrinogen iii oxidase DA68_17635 ENOG4105KVH Transcriptional regulator DA68_17660 ENOG4105TQK DNA polymerase iii, delta' subunit DA68_17670 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DA68_17675 ENOG4108UK2 deaminase DA68_17680 ENOG4105KQC Competence protein DA68_17690 ENOG4105DXX methyltransferase DA68_17700 ENOG4108WF2 Metal Dependent Phosphohydrolase DA68_17710 ENOG410812S Rna-binding protein DA68_17720 ENOG4105CQW ribosome biogenesis GTPase YqeH DA68_17725 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DA68_17740 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DA68_17760 ENOG4108TVJ Nitroreductase DA68_17775 ENOG4105G6Z alkaline phosphatase DA68_17780 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DA68_17785 ENOG4108MUZ hydrolase DA68_17825 ENOG4105MIR Phenylalanine 4-monooxygenase DA68_17835 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DA68_17875 ENOG4105S6R Iron-hydroxamate transporter permease subunit DA68_17880 ENOG4108V5C ABC transporter DA68_17890 ENOG4108EKI Dehydrogenase DA68_17895 ENOG4105C28 cystathionine DA68_17925 ENOG4107XRG penicillin-binding protein DA68_17935 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DA68_17945 ENOG4105CFP Peptidase U32 DA68_17950 ENOG4105XYU peptidase (U32 family) DA68_17955 ENOG4108VQJ O-methyltransferase DA68_17960 ENOG4105HHA aminodeoxychorismate lyase DA68_17980 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DA68_17990 ENOG4105C02 permease DA68_18005 ENOG41060CR DA68_18010 ENOG4105C7H Helicase, RecD TraA family DA68_18020 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DA68_18025 ENOG4105C3J Cysteine desulfurase DA68_18035 ENOG4105D1H recombination factor protein RarA DA68_18040 ENOG4108VCI transcription factor, rsfa family DA68_18045 ENOG4105CUZ uba thif-type nad fad binding protein DA68_18055 ENOG4105CUT histidyl-tRNA synthetase DA68_18065 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DA68_18070 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DA68_18080 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DA68_18085 ENOG41076HS cation diffusion facilitator family transporter DA68_18090 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DA68_18100 ENOG4105CKP Polysaccharide Biosynthesis Protein DA68_18105 ENOG4108QG2 Membrane DA68_18115 ENOG4105VIE preprotein translocase, subunit YajC DA68_18130 ENOG41061AI Protein of unknown function (DUF2905) DA68_18145 ENOG4108HUF Transporter DA68_18175 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DA68_18180 ENOG4108IYU L-aspartate oxidase DA68_18195 ENOG4108RPX mosc domain containing protein DA68_18205 ENOG4105CQC Prephenate dehydratase DA68_18220 ENOG4105C19 ABC transporter DA68_18225 ENOG4105EWM Histidine kinase DA68_18235 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DA68_18250 ENOG4105X36 (ribosomal) protein DA68_18260 ENOG4105C03 ribonuclease DA68_18275 ENOG4107QMS site-determining protein DA68_18290 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DA68_18295 ENOG4105DFF Rod shape-determining protein mreb DA68_18315 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DA68_18320 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DA68_18330 ENOG41068KH stage VI sporulation protein D DA68_18340 ENOG4105D52 delta-aminolevulinic acid dehydratase DA68_18365 ENOG4105K56 Transcriptional regulator DA68_18385 ENOG4108IUQ atp-dependent protease DA68_18405 ENOG4108QCI YvbH-like oligomerisation region DA68_18425 ENOG4105M59 Phosphodiesterase, mj0936 family DA68_18430 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DA68_18440 ENOG4108XJQ germination protein DA68_18455 ENOG4105PFC Transcriptional regulator DA68_18465 ENOG4105DZC cytosine deaminase DA68_18470 ENOG41067S9 phage shock protein C, PspC DA68_18475 ENOG4108JCI Transcriptional regulator DA68_18485 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DA68_18490 ENOG4108Z40 Transcriptional regulator DA68_18495 ENOG4105RHA ABC transporter, permease DA68_18500 ENOG4108IUX (ABC) transporter DA68_18505 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family DA68_18510 ENOG4105ER2 Ompa motb domain protein DA68_18515 ENOG4105E14 MotA TolQ exbB proton channel DA68_18520 ENOG4108VXD carboxy-peptidase DA68_18530 ENOG4105E33 succinate dehydrogenase DA68_18540 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DA68_18550 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DA68_18555 ENOG4105K63 Thioredoxin DA68_18560 ENOG4105C10 Electron transfer flavoprotein DA68_18565 ENOG4105BZJ Electron transfer flavoprotein DA68_18570 ENOG41060WC Enoyl-CoA hydratase DA68_18575 ENOG4107Z3H Transcriptional regulator, TetR family DA68_18580 ENOG4105CEY Amp-dependent synthetase and ligase DA68_18590 ENOG4105J76 Periplasmic binding protein DA68_18645 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DA68_18660 ENOG4105DR4 Methyltransferase DA68_18670 ENOG4105KFN sortase, SrtB family DA68_18675 ENOG4105E0A ABC, transporter DA68_18690 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) DA68_18700 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) DA68_18710 ENOG4105FE9 pseudouridine synthase DA68_18720 ENOG4105DCG PHP domain protein DA68_18735 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DA68_18755 ENOG4105C5S asparaginyl-tRNA synthetase DA68_18760 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DA68_18770 ENOG4108RWN rrna methyltransferase DA68_18800 ENOG4105C0R drug resistance transporter emrb qaca subfamily DA68_18805 ENOG4105CW7 secretion protein, HlyD family DA68_18810 ENOG4108JGH Tetr family transcriptional regulator DA68_18815 ENOG4105CN9 Peptidase m42 family protein DA68_18835 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DA68_18840 ENOG4105C22 threonyL-tRNA synthetase DA68_18845 ENOG4108TDW sporulation protein YtxC DA68_18870 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DA68_18875 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DA68_18880 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DA68_18890 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DA68_18895 ENOG4105C2M dna polymerase I DA68_18900 ENOG4105BZU Histidine kinase DA68_18905 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DA68_18925 ENOG4108HMX isocitrate dehydrogenase (NADP) DA68_18930 ENOG4105BZN citrate synthase DA68_18940 ENOG4108REF Sporulation integral membrane protein ytvi DA68_18945 ENOG4105FS0 cytoplasmic membrane protein DA68_18970 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DA68_18975 ENOG4105C6K Malic enzyme DA68_18980 ENOG4105C0B DNA polymerase III (alpha subunit) DA68_18985 ENOG4105VV2 DA68_18995 ENOG4105SFS phosphoesterase RecJ domain protein DA68_19025 ENOG4105DC7 peptidase M24 DA68_19055 ENOG41082W1 Cupin 2, conserved barrel domain protein DA68_19075 ENOG4107YZX Universal stress protein DA68_19110 ENOG4108JYZ YitT family DA68_19130 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DA68_19140 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DA68_19145 ENOG4105KBJ sporulation protein ytfj DA68_19160 ENOG4105EFZ amidohydrolase DA68_19170 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DA68_19195 ENOG4105RQF LysR family Transcriptional regulator DA68_19205 ENOG4105U5Y Transcriptional regulator DA68_19215 ENOG4105C28 cystathionine DA68_19260 ENOG4105EMN RNA polymerase sigma factor DA68_19270 ENOG4108UW5 maltose o-acetyltransferase DA68_19280 ENOG4105F1V Acetoin utilization protein DA68_19285 ENOG4105W87 Cbs domain DA68_19290 ENOG4105DGU Histone deacetylase DA68_19305 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DA68_19310 ENOG4105BZU Histidine kinase DA68_19315 ENOG4107SNB ankyrin repeat protein YahD DA68_19320 ENOG4105EP9 oxidoreductase DA68_19350 ENOG4105ETE Transcriptional regulator (LacI family DA68_19355 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DA68_19375 ENOG4105C88 aminopeptidase DA68_19410 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DA68_19420 ENOG4108VDD TRNA binding domain protein DA68_19450 ENOG4105C8F Beta-lactamase domain protein DA68_19465 ENOG4108V15 phosphotransferase enzyme family DA68_19470 ENOG4108IUM Glycogen debranching enzyme DA68_19480 ENOG4107QSE Dipeptidase DA68_19485 ENOG4105YW5 deoR family transcriptional regulator DA68_19500 ENOG4105CBX hi0933 family DA68_19535 ENOG4108VJ1 Transcriptional regulator (CarD family DA68_19540 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DA68_19545 ENOG4105CSC Glucose uptake protein DA68_19560 ENOG4108ZAF Molybdopterin DA68_19565 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DA68_19570 ENOG4105CVM Molybdenum cofactor synthesis domain protein DA68_19580 ENOG4105D06 uba thif-type nad fad binding protein DA68_19585 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DA68_19605 ENOG41085GJ domain protein DA68_19615 ENOG4105DWV Homoserine O-trans-acetylase DA68_19625 ENOG4108B31 Spore germination protein DA68_19655 ENOG4105C8T Leucyl-tRNA synthetase DA68_19660 ENOG410605W Major Facilitator DA68_19665 ENOG4107S91 Sodium hydrogen exchanger DA68_19670 ENOG4105NCW Trka-c domain protein DA68_19685 ENOG4105C19 ABC transporter DA68_19705 ENOG4105N5T Radical SAM Protein DA68_19715 ENOG4105CIG ABC transporter DA68_19740 ENOG4105E8V Alpha Beta Hydrolase Fold protein DA68_19745 ENOG4108Z0R Transferase DA68_19750 ENOG4105YVM Phosphoesterase, PA-phosphatase related DA68_19755 ENOG4105BZF Glycosyl transferase (Group 1 DA68_19765 ENOG4105EPU Molybdenum cofactor synthesis domain protein DA68_19780 ENOG4108MK9 spermidine N(1)-acetyltransferase DA68_19820 ENOG4105BZU Histidine kinase DA68_19825 ENOG4105BZU Histidine kinase DA68_19830 ENOG4107S9D Alpha beta hydrolase DA68_19835 ENOG4107T7U Sulfatase DA68_19850 ENOG4105D2X ABC transporter substrate-binding protein DA68_19860 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DA68_19920 ENOG4108V2W Carbonate dehydratase DA68_19925 ENOG4105C4M (Ubiquinol oxidase) subunit I DA68_19930 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DA68_19965 ENOG41087YS Phage shock protein A DA68_19995 ENOG4105BZU Histidine kinase DA68_20000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DA68_20025 ENOG4108UGV hypoxanthine phosphoribosyltransferase DA68_20030 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DA68_20075 ENOG4105C19 ABC transporter DA68_20090 ENOG4107ZTW SNARE associated Golgi DA68_20105 ENOG4105C19 ABC transporter DA68_20110 ENOG41086D8 Transcriptional regulator DA68_20120 ENOG4105CJ1 ABC, transporter DA68_20130 ENOG41082BM Transcriptional regulator, arsr family DA68_20170 ENOG4105C6Z Gluconate DA68_20175 ENOG4105FDP GntR family transcriptional regulator DA68_20195 ENOG41069H0 dihydroorotase EC 3.5.2.3 DA68_20215 ENOG4105DTQ mandelate racemase muconate lactonizing DA68_20225 ENOG4108IPT Naphthoate synthase DA68_20230 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DA68_20240 ENOG4105E4F Isochorismate synthase DA68_20245 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DA68_20255 ENOG4105VEQ Cold shock protein DA68_20290 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DA68_20305 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DA68_20400 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DA68_20435 ENOG4105KT7 mgtC SapB transporter DA68_20440 ENOG4107PBV potassium channel DA68_20455 ENOG4105WG9 Conserved Protein DA68_20465 ENOG4105CHM Aminotransferase DA68_20470 ENOG4108ZB6 transcriptional regulator AsnC family DA68_20475 ENOG4105C5I Dehydrogenase DA68_20480 ENOG4108MUZ hydrolase DA68_20490 ENOG4105C87 Aminotransferase class I and II DA68_20505 ENOG4105Y38 Kinase-associated protein B DA68_20515 ENOG4107R3E Citrate transporter DA68_20530 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) DA68_20535 ENOG4105KA0 thioesterase Superfamily protein DA68_20550 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DA68_20575 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) DA68_20580 ENOG4106YN8 Prenyltransferase DA68_20605 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) DA68_20610 ENOG4106YN8 Prenyltransferase DA68_20615 ENOG41069ER domain protein DA68_20630 ENOG4105CEP NADH dehydrogenase DA68_20660 ENOG4105EWC Purine nucleoside phosphorylase DA68_20670 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DA68_20695 ENOG4108JJA ABC, transporter DA68_20700 ENOG4105C4B ABC transporter, permease DA68_20705 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DA68_20755 ENOG41083MR nifu domain-containing protein DA68_20770 ENOG4108W5N phosphatidylglycerophosphatase a DA68_20790 ENOG4105DAX Pfam:DUF2983 DA68_20805 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DA68_20810 ENOG4105DYS nad(p)h dehydrogenase (quinone) DA68_20815 ENOG4105D4U had-superfamily hydrolase, subfamily iia DA68_20830 ENOG4105CBT Fructose-1,6-bisphosphatase DA68_20845 ENOG4105MMD transcriptional regulator DA68_20850 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DA68_20855 ENOG4107TXC Transcriptional regulator DA68_20860 ENOG41090T1 Membrane DA68_20885 ENOG4105FAA peptidase M23 DA68_20890 ENOG4108YTE sporulation protein YunB DA68_20895 ENOG4105KZD Domain of unknown function (DUF1805) DA68_20900 ENOG4107R8B 5'-nucleotidase DA68_20910 ENOG4105DIW FeS assembly protein SUFB DA68_20915 ENOG4108UNV SUF system FeS assembly protein, NifU family DA68_20920 ENOG4105C9B Cysteine desulfurase DA68_20925 ENOG4105JRK feS assembly protein SufD DA68_20930 ENOG4105C3K feS assembly ATPase SufC DA68_20935 ENOG4105D01 (LipO)protein DA68_20940 ENOG4108UMI ABC transporter, permease DA68_20945 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DA68_20970 ENOG41080E8 Transcriptional regulator, Spx MgsR family DA68_20990 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DA68_21010 ENOG4108W8B Beta-lactamase domain protein DA68_21015 ENOG4105C1G acyl-Coa dehydrogenase DA68_21020 ENOG4105CHU acetyl-coa acetyltransferase DA68_21035 ENOG4105DZ1 carboxypeptidase DA68_21055 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DA68_21070 ENOG4108SUT Major Facilitator Superfamily DA68_21075 ENOG4107R7I amino acid DA68_21090 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DA68_21100 ENOG4107AYK membrAne DA68_21130 ENOG4107ZTW SNARE associated Golgi DA68_21140 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DA68_21145 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DA68_21150 ENOG4105BZU Histidine kinase DA68_21165 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DA68_21180 ENOG4105C8Q Methyl-accepting chemotaxis DA68_21185 ENOG4105VG1 fes assembly suf system protein DA68_21190 ENOG4105D4Y metalloprotease DA68_21210 ENOG4107T5V SNARE associated Golgi DA68_21215 ENOG4107S91 Sodium hydrogen exchanger DA68_21220 ENOG4105NCW Trka-c domain protein DA68_21230 ENOG4108RMU ferritin dps family protein DA68_21245 ENOG4108URH decarboxylase DA68_21255 ENOG41090A1 ferritin DA68_21260 ENOG4105DHF Membrane DA68_21265 ENOG4105D9N nucleoside DA68_21270 ENOG4105D9N nucleoside DA68_21285 ENOG4108RYK Nad-dependent epimerase dehydratase DA68_21300 ENOG4105CV8 reductase DA68_21305 ENOG4105F27 Major Facilitator DA68_21310 ENOG4105KVH Transcriptional regulator DA68_21325 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DA68_21330 ENOG4105D4A Cell wall formation (By similarity) DA68_21340 ENOG4105C8Q Methyl-accepting chemotaxis DA68_21350 ENOG4105WMR Protein CrcB homolog DA68_21355 ENOG4105WMR Protein CrcB homolog DA68_21375 ENOG4105C5H ABC transporter DA68_21380 ENOG4108MK9 spermidine N(1)-acetyltransferase DA68_21385 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DA68_21410 ENOG4108IPW abc transporter atp-binding protein DA68_21415 ENOG4105CM4 permease protein DA68_21475 ENOG4105DZR Type I site-specific deoxyribonuclease DA68_21505 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DA68_21515 ENOG4105XZU Preprotein translocase, subunit SecG DA68_21520 ENOG41067MG lrgb family DA68_21570 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DA68_21580 ENOG4105RHA ABC transporter, permease DA68_21585 ENOG4108IUX (ABC) transporter DA68_21590 ENOG4105BZU Histidine kinase DA68_21595 ENOG4108W5X Transcriptional Regulator, LuxR family DA68_21615 ENOG41090VF Stage v sporulation protein ac DA68_21620 ENOG4105CZ3 stage V sporulation protein ad DA68_21635 ENOG4108QY0 Membrane DA68_21640 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DA68_21650 ENOG4105KRI phosphocarrier protein (HPr DA68_21660 ENOG4105CHW UPF0052 protein DA68_21665 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DA68_21670 ENOG4108Z4K mutator MutT protein DA68_21680 ENOG4105C3M thioredoxin reductase DA68_21690 ENOG4108S4C acetyltransferase DA68_21710 ENOG41086DT Membrane protein of unknown function DA68_21720 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DA68_21725 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DA68_21740 ENOG4107TXC Transcriptional regulator DA68_21760 ENOG4105DUM transcriptional regulator, lysR family DA68_21770 ENOG4108WS4 fmn reductase DA68_21785 ENOG4105BZ1 (ABC) transporter DA68_21795 ENOG4105CN1 protease DA68_21800 ENOG4105CRP Part of the ABC transporter FtsEX involved in DA68_21805 ENOG4105CAK Cell division ATP-binding protein ftsE DA68_21815 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) DA68_21830 ENOG4108RDQ ABC transporter DA68_21860 ENOG4105MS2 ribosomal subunit Interface protein DA68_21865 ENOG4105VEQ Cold shock protein DA68_21870 ENOG41081UC Inherit from COG: Competence protein DA68_21885 ENOG4105KVH Transcriptional regulator DA68_21895 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DA68_21900 ENOG4108KGH TRANSCRIPTIONal DA68_21905 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DA68_21910 ENOG4105C6Y Udp-glucose 6-dehydrogenase DA68_21915 ENOG4105ESV Glycosyl transferase, family 4 DA68_21925 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DA68_21945 ENOG4105F8D glycoside hydrolase family 4 DA68_21950 ENOG4105VCP PTS System DA68_21955 ENOG4105CK1 PTS System DA68_21965 ENOG4105VCP PTS System DA68_21975 ENOG4105VZJ PTS System DA68_21995 ENOG4105ECB domain protein DA68_22000 ENOG4107RSM transcriptional regulator DA68_22035 ENOG4105DAA L-lactate DA68_22045 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) DA68_22055 ENOG4105E0M Sulfatase DA68_22080 ENOG4107R8N Glycosyl transferase, family 2 DA68_22090 ENOG4105C94 Transporter DA68_22095 ENOG41069ER domain protein DA68_22120 ENOG4105KBK Zinc finger, swim domain protein DA68_22125 ENOG4105C0D helicase DA68_22155 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DA68_22165 ENOG4107RBB ABC transporter, permease DA68_22170 ENOG4105C19 ABC transporter DA68_22180 ENOG4105CXY transporter DA68_22195 ENOG4105BZU Histidine kinase DA68_22200 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DA68_22205 ENOG4105CMR udp-glucose 4-epimerase DA68_22215 ENOG4108KGH TRANSCRIPTIONal DA68_22235 ENOG4105BZF Glycosyl transferase (Group 1 DA68_22250 ENOG4108TMJ glycosyl transferase DA68_22255 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DA68_22265 ENOG4105C5E polysaccharide biosynthesis protein DA68_22275 ENOG4105CMR udp-glucose 4-epimerase DA68_22280 ENOG4105D3Q Sugar transferase DA68_22290 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DA68_22295 ENOG4108RB3 Capsular polysaccharide biosynthesis protein DA68_22300 ENOG4107YJ4 chain length determinant protein DA68_22305 ENOG4105HTX biosynthesis protein DA68_22310 ENOG4107YJ4 chain length determinant protein DA68_22325 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DA68_22335 ENOG4105FRN stage II sporulation protein DA68_22350 ENOG4105DY9 regulatoR DA68_22370 ENOG4106778 Protein of unknown function (DUF1146) DA68_22375 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DA68_22380 ENOG4105C8S subunit m DA68_22385 ENOG4105D65 subunit l DA68_22410 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DA68_22415 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DA68_22425 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DA68_22430 ENOG4105BZU Histidine kinase DA68_22480 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DA68_22485 ENOG41062M3 atp synthase DA68_22500 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DA68_22505 ENOG4108UIC UPF0340 protein DA68_22510 ENOG4108YZG isomerase DA68_22525 ENOG4108VGI doxx family DA68_22530 ENOG4107XC4 flavin reductase domain protein, FMN-binding DA68_22550 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DA68_22560 ENOG4108ZXQ stage ii sporulation protein r DA68_22565 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DA68_22570 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DA68_22575 ENOG4107104 thymidine kinase DA68_22585 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DA68_22590 ENOG4105CBT Fructose-1,6-bisphosphatase DA68_22595 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DA68_22615 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DA68_22630 ENOG4105C1G acyl-Coa dehydrogenase DA68_22635 ENOG4105C1G acyl-Coa dehydrogenase DA68_22640 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DA68_22650 ENOG4105DF6 Fe-S oxidoreductase DA68_22665 ENOG4105BZU Histidine kinase DA68_22680 ENOG4105D4Y metalloprotease DA68_22690 ENOG4105BZU Histidine kinase DA68_22695 ENOG4105KCT ABC transporter DA68_22700 ENOG4108M15 ABC transporter DA68_22705 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DA68_22715 ENOG4105IIU Aminopeptidase DA68_22735 ENOG4105EMN RNA polymerase sigma factor DA68_22745 ENOG410684U Domain of unknown function (DUF1934) DA68_22765 ENOG4105CYW agmatinase DA68_22775 ENOG4105DXB Major Facilitator superfamily DA68_22780 ENOG4107SWG transcriptional regulator MERR family DA68_22785 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DA68_22790 ENOG4105BZ4 penicillin-binding protein DA68_22795 ENOG4108XFG YwhD family DA68_22800 ENOG4108Z4T Peptidase M50 DA68_22805 ENOG41069HH 4-oxalocrotonate tautomerase DA68_22810 ENOG4105DCI Phosphohydrolase DA68_22815 ENOG4108MES Periplasmic binding protein DA68_22820 ENOG4105E0A ABC, transporter DA68_22825 ENOG4105EHG Permease protein DA68_22830 ENOG4105DQ5 transport system permease protein DA68_22840 ENOG4108VCI transcription factor, rsfa family DA68_22845 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) DA68_22850 ENOG4108IJ2 phosphate acetyltransferase DA68_22855 ENOG4107UEZ chlorite dismutase DA68_22865 ENOG4108VKI Cell wall hydrolase DA68_22885 ENOG4107SVH Potassium channel protein DA68_22895 ENOG410667J hydrolase DA68_22900 ENOG4105VCH membrane DA68_22910 ENOG4108TU7 Inherit from COG: (ABC) transporter DA68_22915 ENOG4105CJ1 ABC, transporter DA68_22920 ENOG41090WU lipolytic protein G-D-S-L family DA68_22935 ENOG4105D6E homoserine dehydrogenase DA68_22960 ENOG4108Y4K DNA-binding transcriptional activator DA68_22970 ENOG4105WH1 Two component transcriptional regulator luxr family DA68_22975 ENOG4105BZU Histidine kinase DA68_22980 ENOG4105DWF phosphomethylpyrimidine kinase DA68_22985 ENOG4105BZU Histidine kinase DA68_22990 ENOG4105VCD cytoplasmic protein DA68_22995 ENOG4105D22 carbon starvation protein DA68_23000 ENOG4105DY9 regulatoR DA68_23005 ENOG41079KZ Major Facilitator Superfamily DA68_23015 ENOG4105CG5 Glycosyl transferase (Group 1 DA68_23025 ENOG4105EN6 Membrane DA68_23030 ENOG4106YBV Methyl-accepting chemotaxis DA68_23040 ENOG4108S4H thioesterase Superfamily protein DA68_23050 ENOG4105K64 Glycosyl transferase, family 2 DA68_23065 ENOG4105CKK Glycosyl transferase, family 2 DA68_23070 ENOG4105C5H ABC transporter DA68_23075 ENOG41067SE Tetr family transcriptional regulator DA68_23085 ENOG4105E0X reductase DA68_23090 ENOG4106F5Q Membrane DA68_23105 ENOG4108NEV two component transcriptional regulator, LytTR family DA68_23110 ENOG4108HRK Histidine kinase DA68_23115 ENOG4107RGD Major Facilitator superfamily DA68_23130 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DA68_23140 ENOG4105IW1 AmiS UreI transporter DA68_23145 ENOG4105CMR udp-glucose 4-epimerase DA68_23150 ENOG4108UT2 hemolysin iii DA68_23160 ENOG4105C1J atp-dependent rna helicase DA68_23165 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) DA68_23170 ENOG4105DPN Oligoendopeptidase f DA68_23180 ENOG4105BZU Histidine kinase DA68_23185 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DA68_23195 ENOG4105C0H protease DA68_23200 ENOG4105Q2H domain protein DA68_23215 ENOG4105BZU Histidine kinase DA68_23220 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DA68_23245 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DA68_23250 ENOG4105CDU Replicative dna helicase DA68_23260 ENOG4105BZR domain protein DA68_23265 ENOG4108XMW Membrane DA68_23275 ENOG4108UUM single-stranded DNA-binding protein DA68_23285 ENOG4105C3G gtp-binding protein DA68_23290 ENOG4105VDK protein, conserved in bacteria DA68_23295 ENOG4105D8X mechanosensitive ion channel DA68_23300 ENOG4108ZDA Sporulation protein YyaC DA68_23305 ENOG4105FA0 parb-like partition protein DA68_23310 ENOG4107QJE Chromosome Partitioning Protein DA68_23325 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DA68_23330 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DA68_23340 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DA68_23360 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DA68_23365 ENOG410848D S4 domain protein YaaA DA68_23380 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DA68_23415 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DA68_23450 ENOG4105ZMH deoxynucleoside kinase DA68_23460 ENOG4105GTG Isochorismatase DA68_23465 ENOG4108Z6B deaminase DA68_23475 ENOG4105C6E dna polymerase iii DA68_23495 ENOG41067KS pro-sigma K processing DA68_23530 ENOG4105CXN decarboxylase DA68_23540 ENOG4105FA2 dna polymerase iii DA68_23545 ENOG4105MA4 psp1 domain protein DA68_23555 ENOG41060K3 Methyltransferase DA68_23565 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DA68_23570 ENOG4105KRN Transcriptional regulator, abrb family DA68_23575 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DA68_23580 ENOG4105F8V Hydrolase, tatD family DA68_23585 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DA68_23595 ENOG4105XFA sporulation peptidase YabG DA68_23600 ENOG4105W42 Veg protein DA68_23615 ENOG4105DFT pur operon repressor DA68_23620 ENOG4105KME endoribonuclease L-psp DA68_23635 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DA68_23640 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DA68_23650 ENOG4108JA2 transcriptioN-repair coupling factor DA68_23655 ENOG4108M14 stage v sporulation protein t DA68_23665 ENOG4108IY2 MazG family DA68_23670 ENOG41082I2 s4 domain protein DA68_23675 ENOG4105VYY sporulation protein yabp DA68_23690 ENOG41060GV RNA binding s1 domain protein DA68_23710 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DA68_23715 ENOG4108UGV hypoxanthine phosphoribosyltransferase DA68_23720 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DA68_23735 ENOG4105C6T cysteine synthase DA68_23740 ENOG4105CRQ synthase (Component I) DA68_23745 ENOG4105DDQ anthranilate synthase DA68_23750 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DA68_23755 ENOG4105EEI dihydropteroate synthase DA68_23760 ENOG4105KRF dihydroneopterin aldolase DA68_23765 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DA68_23775 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DA68_23865 ENOG4108Z0C Uvrb UvrC protein DA68_23880 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DA68_23890 ENOG4105CTP PilT protein domain protein DA68_23895 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DA68_23910 ENOG4105D7W serine acetyltransferase DA68_23925 ENOG4105C2N RNA methyltransferase TrmH family group 3 DA68_23930 ENOG4105M0M Tetracycline resistance protein DA68_23935 ENOG4105QIV RNA polymerase DA68_23945 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DA68_23970 ENOG4107Y49 methyltransferase DA68_23985 ENOG4105XPM ribosomal protein DA68_24090 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DA68_24115 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DA68_24125 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DA68_24135 ENOG41067V7 50S ribosomal protein L36 DA68_24160 ENOG4108JJB ABC transporter DA68_24165 ENOG4108JJB ABC transporter DA68_24170 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DA68_24175 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DA68_24200 ENOG4105D1F ATP-binding protein DA68_24215 ENOG4108NMV polysaccharide deacetylase DA68_24295 ENOG4105C8B TIGR00159 family DA68_24300 ENOG4107U5W ybbr family DA68_24315 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DA68_24340 ENOG4108PSK reductase DA68_24345 ENOG4108UMI ABC transporter, permease DA68_24350 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DA68_24355 ENOG4105D01 (LipO)protein DA68_24370 ENOG4105IQ5 FAD linked oxidase domain protein DA68_24385 ENOG4105C2C drug resistance transporter, Bcr CflA DA68_24415 ENOG4108J59 Extracellular solute-binding protein, family 5 DA68_24420 ENOG4108J59 Extracellular solute-binding protein, family 5 DA68_24440 ENOG4105E0C molybdate abc transporter DA68_24445 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DA68_24450 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DA68_24455 ENOG4105EGI Transcriptional regulator DA68_24470 ENOG4105F6E Acyl-transferase DA68_24485 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DA68_24510 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DA68_24530 ENOG4105C5H ABC transporter DA68_24540 ENOG4105DEF Extracellular solute-binding protein, family 5 DA68_24550 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DA68_24555 ENOG4105C3U ABC transporter DA68_24560 ENOG4108JQ7 (ABC) transporter DA68_24565 ENOG410667J hydrolase DA68_24595 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DA68_24600 ENOG4105ERH Fumarylacetoacetate hydrolase DA68_24610 ENOG4105CUB amino acid DA68_24615 ENOG4108SC4 )-transporter DA68_24620 ENOG4105CPF Cell wall formation (By similarity) DA68_24625 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DA68_24650 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DA68_24655 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DA68_24665 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DA68_24765 ENOG4105K8N protein family UPF0079, ATPase DA68_24770 ENOG41072GX Peptidase M22 Glycoprotease DA68_24775 ENOG410801F ribosomal-protein-alanine acetyltransferase DA68_24780 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DA68_24785 ENOG4105C5H ABC transporter DA68_24800 ENOG4108TYN CAAX amino terminal protease family protein DA68_24820 ENOG4105C7N Xanthine uracil vitamin C permease DA68_24830 ENOG4105BZU Histidine kinase DA68_24855 ENOG4107ZXU DSBA oxidoreductase DA68_24900 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DA68_24935 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) DA68_24965 ENOG4105SX7 Transporter DA68_24995 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DA68_25000 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DA68_25005 ENOG4105C83 adenylosuccinate lyase DA68_25015 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DA68_25040 ENOG4108V3E phosphoribosylglycinamide formyltransferase DA68_25050 ENOG4105C12 Phosphoribosylglycinamide synthetase DA68_25075 ENOG4105C4R Atp-dependent dna helicase DA68_25080 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DA68_25100 ENOG4108W2Y isochorismatase DA68_25105 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DA68_25110 ENOG4108UMI ABC transporter, permease DA68_25115 ENOG4105D01 (LipO)protein DA68_25130 ENOG410834F Transcriptional regulator DA68_25135 ENOG4107I77 yiaA/B two helix domain DA68_25155 ENOG4105CBD Diacylglycerol kinase DA68_25160 ENOG4105D7V transposase DA68_25165 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DA68_25170 ENOG4108JPW Aminotransferase DA68_25180 ENOG4105C26 Dehydrogenase DA68_25185 ENOG4105KPY Small multidrug resistance protein DA68_25210 ENOG4105D9N nucleoside DA68_25215 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DA68_25225 ENOG4108W15 Protein of unknown function (DUF1456) DA68_25240 ENOG4105DTQ mandelate racemase muconate lactonizing DA68_25250 ENOG4105DFD Na H antiporter DA68_25270 ENOG4105D3R alkyl hydroperoxide reductase DA68_25275 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) DA68_25280 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DA68_25285 ENOG4107W7X Aldolase DA68_25290 ENOG4105EHG Permease protein DA68_25295 ENOG4105DQ5 transport system permease protein DA68_25300 ENOG4108V5C ABC transporter DA68_25305 ENOG4105CAY ferredoxin--nadp reductase DA68_25320 ENOG4106UIA DA68_25325 ENOG4106UIA DA68_25340 ENOG4105BZU Histidine kinase DA68_25360 ENOG410756H nucleotidyltransferase DA68_25365 ENOG4105D2S major facilitator superfamily DA68_25380 ENOG4105E5Q amino acid AbC transporter DA68_25385 ENOG4105EAB amino acid AbC transporter DA68_25395 ENOG4105C8Q Methyl-accepting chemotaxis DA68_25410 ENOG4105DBV ornithine carbamoyltransferase DA68_25420 ENOG4105C5B carbamate kinase DA68_25425 ENOG4108W63 CRP FNR family transcriptional regulator DA68_25445 ENOG4105CI1 PTS System DA68_25460 ENOG4105C9U ATP-dependent DNA helicase RecQ DA68_25475 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter DA68_25495 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DA68_25500 ENOG4105D2X ABC transporter substrate-binding protein DA68_25535 ENOG41062JF Transcriptional regulator DA68_25550 ENOG4105DEU major facilitator superfamily DA68_25565 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DA68_25580 ENOG4108N0M stress protein DA68_25585 ENOG4106FN3 tellurium resistance protein DA68_25590 ENOG4106FN3 tellurium resistance protein DA68_25595 ENOG4107TS3 membrane protein, TerC DA68_25600 ENOG4108TTB tellurium resistance protein DA68_25620 ENOG4105KJF protein tyrosine phosphatase DA68_25630 ENOG4107U9T Pfam:Ribonuclease_BN DA68_25635 ENOG4105C59 p-type ATPase DA68_25640 ENOG4108IPJ Membrane DA68_25650 ENOG4105C3F Signal peptidase i DA68_25660 ENOG4107ZTW SNARE associated Golgi DA68_25675 ENOG410606W general stress protein DA68_25680 ENOG4105UPD Calcium Proton DA68_25715 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DA68_25720 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DA68_25730 ENOG4108JUB Transcriptional regulator DA68_25740 ENOG4108IQI permease DA68_25775 ENOG4108A04 Beta-lactamase DA68_25790 ENOG4105CKK Glycosyl transferase, family 2 DA68_25795 ENOG4107QQG Dehydrogenase DA68_25800 ENOG4105C3I Nad-dependent epimerase dehydratase DA68_25820 ENOG4105F1A Pyruvate formate-lyase DA68_25825 ENOG4108QBV Monogalactosyldiacylglycerol synthase DA68_25840 ENOG4105CI2 imidazolone-5-propionate hydrolase DA68_25845 ENOG4105ECP epimerase DA68_25875 ENOG41067AE Membrane-bound metal-dependent hydrolase DA68_25880 ENOG4105CEN a g-specific adenine glycosylase DA68_25885 ENOG4106BXE DA68_25905 ENOG4105BZ1 (ABC) transporter DA68_25910 ENOG4107NBY Membrane DA68_25915 ENOG4105CBC glutamate synthase DA68_25925 ENOG4108IUW ABC transporter DA68_25945 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DA68_25950 ENOG4105G5W regulator Fur family DA68_26055 ENOG4105CDY transcriptional regulatory protein DA68_26065 ENOG4108JQC penicillin-binding protein 1A DA68_26070 ENOG4108R9S DSBA oxidoreductase DA68_26080 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DA68_26090 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DA68_26100 ENOG4105CYN Serine protein kinase DA68_26120 ENOG4105C94 Transporter DA68_26135 ENOG4105DZ6 Band 7 protein DA68_26145 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DA68_26150 ENOG4108V9W transcriptional regulatory protein DA68_26155 ENOG4105D4T Citrate transporter DA68_26180 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DA68_26185 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DA68_26190 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DA68_26195 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DA68_26200 ENOG4105BZ7 extracellular solute-binding protein family 1 DA68_26205 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DA68_26210 ENOG4108STX response regulator DA68_26240 ENOG4108MRH transcriptional regulatory protein DA68_26250 ENOG4105C6K Malic enzyme DA68_26260 ENOG4108UZ3 Transporter DA68_26265 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DA68_26275 ENOG4105BZU Histidine kinase DA68_26280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DA68_26295 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DA68_26300 ENOG4108JB9 formate dehydrogenase DA68_26320 ENOG4105CUB amino acid DA68_26335 ENOG4105C59 p-type ATPase DA68_26340 ENOG4105DAP Nicotinate phosphoribosyltransferase DA68_26370 ENOG41073R8 VanW family DA68_26375 ENOG4108KGH TRANSCRIPTIONal DA68_26380 ENOG4105D9N nucleoside DA68_26385 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DA68_26390 ENOG4105C37 (CBS) domain DA68_26395 ENOG4108IJ0 Aspartate ammonia-lyase DA68_26400 ENOG4105DAA L-lactate DA68_26415 ENOG4105DUX Transporter DA68_26420 ENOG4108MES Periplasmic binding protein DA68_26425 ENOG4105DQ5 transport system permease protein DA68_26430 ENOG4108IHU transport system permease protein DA68_26435 ENOG4105E0A ABC, transporter DA68_26440 ENOG4105DMQ Methyltransferase DA68_26445 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DA68_26450 ENOG4105EXW epimerase dehydratase DA68_26460 ENOG4107T89 von Willebrand factor, type A DA68_26465 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DA68_26470 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DA68_26480 ENOG4105BZU Histidine kinase DA68_26485 ENOG4105D5Q Arginine ornithine antiporter DA68_26490 ENOG4107414 GntR family transcriptional regulator DA68_26495 ENOG4105C5Y PTS System DA68_26500 ENOG4105CG3 alpha amylase, catalytic region DA68_26515 ENOG4105E1K spore germination protein DA68_26520 ENOG4105CRN Aminoglycoside phosphotransferase DA68_26525 ENOG4105BZG amino acid carrier protein DA68_26535 ENOG4105CDA abc transporter atp-binding protein DA68_26540 ENOG4105CT1 (ABC) transporter DA68_26545 ENOG4105EAD ABC transporter DA68_26550 ENOG4105DRP amino acid AbC transporter DA68_26555 ENOG4108IQI permease DA68_26570 ENOG4105GFR rna polymerase sigma factor DA68_26580 ENOG4105D29 Helix-turn-helix type 11 domain protein DA68_26585 ENOG4105NAE bifunctional deaminase-reductase domain protein DA68_26590 ENOG4105BZU Histidine kinase DA68_26605 ENOG4105CHH sulfate transporter DA68_26610 ENOG41068KF Universal stress protein DA68_26620 ENOG4105CXY transporter DA68_26625 ENOG41067TZ transcriptional regulator, MarR family DA68_26630 ENOG4105C0R drug resistance transporter emrb qaca subfamily DA68_26635 ENOG4105ETE Transcriptional regulator (LacI family DA68_26640 ENOG4108RVA ribokinase DA68_26650 ENOG4105C2J ABC transporter DA68_26655 ENOG4105CNN ABC, transporter DA68_26660 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DA68_26690 ENOG41067FT ParB-like nuclease domain DA68_26710 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) DA68_26720 ENOG410874W AraC family transcriptional regulator DA68_26750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DA68_26760 ENOG4105YWU small acid-soluble spore protein DA68_26790 ENOG4106A3M Cytochrome p-450 DA68_26795 ENOG410625E DA68_26800 ENOG4105C8Q Methyl-accepting chemotaxis DA68_26815 ENOG4108JJB ABC transporter DA68_26825 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DA68_26835 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DA68_26840 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DA68_26845 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DA68_26850 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DA68_26865 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) DA68_26875 ENOG4105CHR reductase DA68_26880 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DA68_26890 ENOG4108KYE ABC-2 type transporter DA68_26895 ENOG4105CJ1 ABC, transporter DA68_26900 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein DA68_27005 ENOG4105KRN Transcriptional regulator, abrb family DA68_27010 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DA68_27020 ENOG4105F3R pts system mannose fructose sorbose family iid DA68_27025 ENOG4105ETZ PTS System DA68_27035 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DA68_27040 ENOG4105KRI phosphocarrier protein (HPr DA68_27050 ENOG4105CMT Dihydroxyacetone kinase DA68_27055 ENOG4108JUA Transcriptional regulator DA68_27065 ENOG4108NNZ chitinase DA68_27080 ENOG4105CZV ABC transporter DA68_27095 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C DA68_27115 ENOG4107WD8 ABC transporter, permease DA68_27125 ENOG4105EA8 2-Nitropropane dioxygenase DA68_27155 ENOG4105CUB amino acid DA68_27160 ENOG4105C7B Threonine dehydratase DA68_27170 ENOG4107R7I amino acid DA68_27180 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DA68_27185 ENOG4108QTI )-transporter DA68_27200 ENOG4105D7V transposase DA68_27210 ENOG4105DS0 Transcriptional regulator, Crp Fnr family DA68_27215 ENOG4105VCQ rubredoxin DA68_27220 ENOG4108IFG nitrite reductase, (NAD(P)H) DA68_27225 ENOG4105CNW domain protein DA68_27245 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DA68_27250 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) DA68_27265 ENOG4108EKI Dehydrogenase DA68_27450 ENOG4107A6P DA68_27455 ENOG4105KRN Transcriptional regulator, abrb family DA68_27490 ENOG4105VXR cytoplasmic protein DA68_27495 ENOG4105VZ8 Transcriptional regulator DA68_27500 ENOG4107D63 DA68_27510 ENOG4105CHH sulfate transporter DA68_27530 ENOG4105D7V transposase DA68_27595 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DA68_27610 ENOG4105DM4 PTS System DA68_27615 ENOG4105DG6 mannose-6-phosphate isomerase DA68_27620 ENOG4108IQI permease DA68_27625 ENOG4108J5H Homocysteine s-methyltransferase DA68_27640 ENOG4105NA0 Transcriptional regulator DA68_27660 ENOG4105ZUU Transcriptional regulator DA68_27675 ENOG4107SET aldo keto reductase DA68_27710 ENOG4105C0W non-ribosomal peptide synthetase DA68_27710 ENOG4105C0W non-ribosomal peptide synthetase DA68_27720 ENOG4105CEY Amp-dependent synthetase and ligase DA68_27730 ENOG4105C1G acyl-Coa dehydrogenase DA68_27745 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DA68_27750 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) DA68_27765 ENOG4105C0W non-ribosomal peptide synthetase DA68_27770 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DA68_27775 ENOG4105IBP Cyclic peptide transporter DA68_27900 ENOG4105XSJ toxin secretion phage lysis holin DA68_27905 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DA68_27915 ENOG4108IBT Inherit from COG: transposase DA68_27925 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DA68_27980 ENOG4107QJE Chromosome Partitioning Protein DA68_28050 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) DA68_28135 ENOG4106CVF DNA replication protein DA68_28160 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)