locus-tag class description EJ379_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EJ379_00015 ENOG410848D S4 domain protein YaaA EJ379_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJ379_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EJ379_00080 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) EJ379_00100 ENOG4105ZMH deoxynucleoside kinase EJ379_00110 ENOG4105GTG Isochorismatase EJ379_00120 ENOG4108Z6B deaminase EJ379_00130 ENOG4105C6E dna polymerase iii EJ379_00150 ENOG41067KS pro-sigma K processing EJ379_00185 ENOG4105CXN decarboxylase EJ379_00190 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EJ379_00195 ENOG4105FA2 dna polymerase iii EJ379_00200 ENOG4105MA4 psp1 domain protein EJ379_00210 ENOG41060K3 Methyltransferase EJ379_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EJ379_00225 ENOG4105KRN Transcriptional regulator, abrb family EJ379_00230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EJ379_00235 ENOG4105F8V Hydrolase, tatD family EJ379_00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) EJ379_00250 ENOG4105XFA sporulation peptidase YabG EJ379_00255 ENOG4105W42 Veg protein EJ379_00270 ENOG4105DFT pur operon repressor EJ379_00275 ENOG4105KME endoribonuclease L-psp EJ379_00295 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) EJ379_00305 ENOG4108JA2 transcriptioN-repair coupling factor EJ379_00310 ENOG4108M14 stage v sporulation protein t EJ379_00320 ENOG4108IY2 MazG family EJ379_00325 ENOG41082I2 s4 domain protein EJ379_00330 ENOG4105VYY sporulation protein yabp EJ379_00345 ENOG41060GV RNA binding s1 domain protein EJ379_00365 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EJ379_00370 ENOG4108UGV hypoxanthine phosphoribosyltransferase EJ379_00375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EJ379_00390 ENOG4105C6T cysteine synthase EJ379_00395 ENOG4105CRQ synthase (Component I) EJ379_00400 ENOG4105DDQ anthranilate synthase EJ379_00405 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 EJ379_00410 ENOG4105EEI dihydropteroate synthase EJ379_00415 ENOG4105KRF dihydroneopterin aldolase EJ379_00420 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EJ379_00430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EJ379_00520 ENOG4108Z0C Uvrb UvrC protein EJ379_00535 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EJ379_00540 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) EJ379_00545 ENOG4105CTP PilT protein domain protein EJ379_00550 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EJ379_00565 ENOG4105D7W serine acetyltransferase EJ379_00580 ENOG4105C2N RNA methyltransferase TrmH family group 3 EJ379_00585 ENOG4105M0M Tetracycline resistance protein EJ379_00590 ENOG4105QIV RNA polymerase EJ379_00605 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EJ379_00610 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EJ379_00620 ENOG4108VZM 50s ribosomal protein L10 EJ379_00630 ENOG4107Y49 methyltransferase EJ379_00645 ENOG4105XPM ribosomal protein EJ379_00780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EJ379_00790 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EJ379_00825 ENOG4108JJB ABC transporter EJ379_00830 ENOG4108JJB ABC transporter EJ379_00835 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) EJ379_00840 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EJ379_00865 ENOG4105D1F ATP-binding protein EJ379_00880 ENOG4108NMV polysaccharide deacetylase EJ379_00960 ENOG4105C8B TIGR00159 family EJ379_00965 ENOG4107U5W ybbr family EJ379_00980 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EJ379_01005 ENOG4108PSK reductase EJ379_01010 ENOG4108UMI ABC transporter, permease EJ379_01015 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EJ379_01020 ENOG4105D01 (LipO)protein EJ379_01025 ENOG4105CB2 alcohol dehydrogenase EJ379_01035 ENOG4105IQ5 FAD linked oxidase domain protein EJ379_01050 ENOG4105C2C drug resistance transporter, Bcr CflA EJ379_01070 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EJ379_01075 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ379_01080 ENOG4105C3U ABC transporter EJ379_01085 ENOG4108JQ7 (ABC) transporter EJ379_01115 ENOG4108J59 Extracellular solute-binding protein, family 5 EJ379_01120 ENOG4108J59 Extracellular solute-binding protein, family 5 EJ379_01140 ENOG4105E0C molybdate abc transporter EJ379_01145 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EJ379_01150 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family EJ379_01160 ENOG4105EGI Transcriptional regulator EJ379_01180 ENOG4105F6E Acyl-transferase EJ379_01200 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EJ379_01215 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) EJ379_01235 ENOG4105C5H ABC transporter EJ379_01250 ENOG4105DEF Extracellular solute-binding protein, family 5 EJ379_01260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ379_01265 ENOG4105C3U ABC transporter EJ379_01270 ENOG4108JQ7 (ABC) transporter EJ379_01275 ENOG410667J hydrolase EJ379_01305 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase EJ379_01310 ENOG4105ERH Fumarylacetoacetate hydrolase EJ379_01320 ENOG4105CUB amino acid EJ379_01325 ENOG4108SC4 )-transporter EJ379_01330 ENOG4105CPF Cell wall formation (By similarity) EJ379_01335 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) EJ379_01360 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein EJ379_01365 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EJ379_01375 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EJ379_01480 ENOG4105K8N protein family UPF0079, ATPase EJ379_01485 ENOG41072GX Peptidase M22 Glycoprotease EJ379_01490 ENOG410801F ribosomal-protein-alanine acetyltransferase EJ379_01495 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EJ379_01500 ENOG4105C5H ABC transporter EJ379_01515 ENOG4108TYN CAAX amino terminal protease family protein EJ379_01530 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EJ379_01535 ENOG4105C7N Xanthine uracil vitamin C permease EJ379_01545 ENOG4105BZU Histidine kinase EJ379_01570 ENOG4107ZXU DSBA oxidoreductase EJ379_01600 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EJ379_01610 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) EJ379_01620 ENOG4108SHN Glycosyl transferase, family 2 EJ379_01640 ENOG4105SX7 Transporter EJ379_01670 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EJ379_01675 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EJ379_01680 ENOG4105C83 adenylosuccinate lyase EJ379_01690 ENOG4105VR9 phosphoribosylformylglycinamidine synthase EJ379_01700 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii EJ379_01715 ENOG4108V3E phosphoribosylglycinamide formyltransferase EJ379_01720 ENOG4105DC1 bifunctional purine biosynthesis protein purh EJ379_01725 ENOG4105C12 Phosphoribosylglycinamide synthetase EJ379_01755 ENOG4105C4R Atp-dependent dna helicase EJ379_01760 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EJ379_01780 ENOG4108W2Y isochorismatase EJ379_01790 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EJ379_01795 ENOG4108UMI ABC transporter, permease EJ379_01800 ENOG4105D01 (LipO)protein EJ379_01805 ENOG4107I77 yiaA/B two helix domain EJ379_01815 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EJ379_01825 ENOG4105CBD Diacylglycerol kinase EJ379_01835 ENOG4108JPW Aminotransferase EJ379_01845 ENOG4105C26 Dehydrogenase EJ379_01850 ENOG4105KPY Small multidrug resistance protein EJ379_01875 ENOG4105D9N nucleoside EJ379_01880 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EJ379_01900 ENOG4108W15 Protein of unknown function (DUF1456) EJ379_01920 ENOG4105DTQ mandelate racemase muconate lactonizing EJ379_01930 ENOG4105DFD Na H antiporter EJ379_01950 ENOG4105D3R alkyl hydroperoxide reductase EJ379_01970 ENOG4105EHG Permease protein EJ379_01975 ENOG4105DQ5 transport system permease protein EJ379_01980 ENOG4108V5C ABC transporter EJ379_02010 ENOG4106UIA EJ379_02015 ENOG4106UIA EJ379_02030 ENOG4105BZU Histidine kinase EJ379_02050 ENOG410756H nucleotidyltransferase EJ379_02055 ENOG4105D2S major facilitator superfamily EJ379_02070 ENOG4105E5Q amino acid AbC transporter EJ379_02075 ENOG4105EAB amino acid AbC transporter EJ379_02080 ENOG4105CDA abc transporter atp-binding protein EJ379_02085 ENOG4105C8Q Methyl-accepting chemotaxis EJ379_02100 ENOG4105DBV ornithine carbamoyltransferase EJ379_02110 ENOG4105C5B carbamate kinase EJ379_02115 ENOG4108W63 CRP FNR family transcriptional regulator EJ379_02125 ENOG4105DNP FAD linked oxidase domain protein EJ379_02135 ENOG4105CI1 PTS System EJ379_02150 ENOG4105C9U ATP-dependent DNA helicase RecQ EJ379_02155 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase EJ379_02160 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EJ379_02165 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter EJ379_02185 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EJ379_02190 ENOG4105D2X ABC transporter substrate-binding protein EJ379_02235 ENOG41062JF Transcriptional regulator EJ379_02250 ENOG4105DEU major facilitator superfamily EJ379_02265 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EJ379_02280 ENOG4108N0M stress protein EJ379_02285 ENOG4106FN3 tellurium resistance protein EJ379_02290 ENOG4106FN3 tellurium resistance protein EJ379_02295 ENOG4107TS3 membrane protein, TerC EJ379_02300 ENOG4108TTB tellurium resistance protein EJ379_02320 ENOG4105KJF protein tyrosine phosphatase EJ379_02330 ENOG4107U9T Pfam:Ribonuclease_BN EJ379_02335 ENOG4105C59 p-type ATPase EJ379_02340 ENOG4108IPJ Membrane EJ379_02350 ENOG4105C3F Signal peptidase i EJ379_02360 ENOG4107ZTW SNARE associated Golgi EJ379_02375 ENOG410606W general stress protein EJ379_02380 ENOG4105UPD Calcium Proton EJ379_02415 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EJ379_02430 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EJ379_02440 ENOG4108JUB Transcriptional regulator EJ379_02450 ENOG4108IQI permease EJ379_02490 ENOG4108A04 Beta-lactamase EJ379_02505 ENOG4105CKK Glycosyl transferase, family 2 EJ379_02510 ENOG4107QQG Dehydrogenase EJ379_02515 ENOG4105C3I Nad-dependent epimerase dehydratase EJ379_02535 ENOG4105F1A Pyruvate formate-lyase EJ379_02540 ENOG4108QBV Monogalactosyldiacylglycerol synthase EJ379_02555 ENOG4105CI2 imidazolone-5-propionate hydrolase EJ379_02560 ENOG4105ECP epimerase EJ379_02590 ENOG41067AE Membrane-bound metal-dependent hydrolase EJ379_02595 ENOG4105CEN a g-specific adenine glycosylase EJ379_02600 ENOG4106BXE EJ379_02620 ENOG4105BZ1 (ABC) transporter EJ379_02625 ENOG4107NBY Membrane EJ379_02630 ENOG4105CBC glutamate synthase EJ379_02640 ENOG4108IUW ABC transporter EJ379_02660 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EJ379_02665 ENOG4105G5W regulator Fur family EJ379_02785 ENOG4108JQC penicillin-binding protein 1A EJ379_02790 ENOG4108R9S DSBA oxidoreductase EJ379_02800 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EJ379_02810 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EJ379_02815 ENOG4105BZU Histidine kinase EJ379_02820 ENOG4105CYN Serine protein kinase EJ379_02825 ENOG4106AKX UPF0229 protein EJ379_02840 ENOG4105C94 Transporter EJ379_02855 ENOG4105DZ6 Band 7 protein EJ379_02865 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EJ379_02870 ENOG4108V9W transcriptional regulatory protein EJ379_02875 ENOG4105D4T Citrate transporter EJ379_02895 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator EJ379_02900 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJ379_02905 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EJ379_02910 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component EJ379_02915 ENOG4105BZ7 extracellular solute-binding protein family 1 EJ379_02920 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) EJ379_02925 ENOG4108STX response regulator EJ379_02930 ENOG4105US7 Histidine kinase EJ379_02955 ENOG4108MRH transcriptional regulatory protein EJ379_02965 ENOG4105C6K Malic enzyme EJ379_02975 ENOG4108UZ3 Transporter EJ379_02980 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJ379_02990 ENOG4105BZU Histidine kinase EJ379_02995 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_03000 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EJ379_03005 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EJ379_03010 ENOG4108JB9 formate dehydrogenase EJ379_03030 ENOG4105CUB amino acid EJ379_03040 ENOG4105C59 p-type ATPase EJ379_03045 ENOG4105DAP Nicotinate phosphoribosyltransferase EJ379_03090 ENOG41073R8 VanW family EJ379_03095 ENOG4108KGH TRANSCRIPTIONal EJ379_03100 ENOG4105D9N nucleoside EJ379_03105 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase EJ379_03110 ENOG4105C37 (CBS) domain EJ379_03115 ENOG4108IJ0 Aspartate ammonia-lyase EJ379_03120 ENOG4105DAA L-lactate EJ379_03140 ENOG4105DUX Transporter EJ379_03145 ENOG4108MES Periplasmic binding protein EJ379_03150 ENOG4105DQ5 transport system permease protein EJ379_03155 ENOG4108IHU transport system permease protein EJ379_03160 ENOG4105E0A ABC, transporter EJ379_03170 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EJ379_03175 ENOG4105EXW epimerase dehydratase EJ379_03185 ENOG4107T89 von Willebrand factor, type A EJ379_03190 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EJ379_03195 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EJ379_03205 ENOG4105BZU Histidine kinase EJ379_03210 ENOG4105D5Q Arginine ornithine antiporter EJ379_03215 ENOG4107414 GntR family transcriptional regulator EJ379_03220 ENOG4105C5Y PTS System EJ379_03225 ENOG4105CG3 alpha amylase, catalytic region EJ379_03240 ENOG4105E1K spore germination protein EJ379_03250 ENOG4105CRN Aminoglycoside phosphotransferase EJ379_03255 ENOG4105BZG amino acid carrier protein EJ379_03260 ENOG4105CDA abc transporter atp-binding protein EJ379_03265 ENOG4105CT1 (ABC) transporter EJ379_03270 ENOG4105EAD ABC transporter EJ379_03275 ENOG4105DRP amino acid AbC transporter EJ379_03280 ENOG4108IQI permease EJ379_03305 ENOG4105D29 Helix-turn-helix type 11 domain protein EJ379_03310 ENOG4105NAE bifunctional deaminase-reductase domain protein EJ379_03315 ENOG4105BZU Histidine kinase EJ379_03320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_03330 ENOG4105CHH sulfate transporter EJ379_03335 ENOG41068KF Universal stress protein EJ379_03345 ENOG4105CXY transporter EJ379_03350 ENOG41067TZ transcriptional regulator, MarR family EJ379_03355 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJ379_03360 ENOG4105ETE Transcriptional regulator (LacI family EJ379_03365 ENOG4108RVA ribokinase EJ379_03370 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EJ379_03375 ENOG4105C2J ABC transporter EJ379_03380 ENOG4105CNN ABC, transporter EJ379_03385 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EJ379_03390 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EJ379_03430 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) EJ379_03460 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EJ379_03465 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer EJ379_03470 ENOG41069ER domain protein EJ379_03475 ENOG4105VZ8 Transcriptional regulator EJ379_03480 ENOG4107D63 EJ379_03495 ENOG4105DUX Transporter EJ379_03515 ENOG4105C85 amino acid EJ379_03520 ENOG4105C7N Xanthine uracil vitamin C permease EJ379_03535 ENOG4105MA6 gCN5-related N-acetyltransferase EJ379_03560 ENOG4105BZ9 Cytochrome C oxidase, subunit I EJ379_03565 ENOG4105E2S oxidase) subunit II EJ379_03585 ENOG4106CAD Protein of unknown function (DUF3311) EJ379_03590 ENOG4105E1V na solute symporter EJ379_03605 ENOG4108NHD germination protein EJ379_03610 ENOG4105CE1 Ferrous iron transport protein b EJ379_03615 ENOG4105CE1 Ferrous iron transport protein b EJ379_03620 ENOG4105CE1 Ferrous iron transport protein b EJ379_03625 ENOG4105CVA phosphate EJ379_03630 ENOG4105C8U phosphate abc transporter EJ379_03635 ENOG4105E2Z phosphate ABC transporter (Permease EJ379_03765 ENOG41080XQ Signal transduction protein with cbs domains EJ379_03785 ENOG4105ETU transcriptional activator (TenA EJ379_03795 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EJ379_03805 ENOG4108VEU Thiamine monophosphate synthase EJ379_03810 ENOG41080HI glycine oxidase EJ379_03820 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EJ379_03825 ENOG4105D06 uba thif-type nad fad binding protein EJ379_03830 ENOG4105DWF phosphomethylpyrimidine kinase EJ379_03860 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EJ379_03865 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) EJ379_03880 ENOG4108INS Transcriptional regulator EJ379_03905 ENOG4105C19 ABC transporter EJ379_03920 ENOG4105CNN ABC, transporter EJ379_03935 ENOG4105C7N Xanthine uracil vitamin C permease EJ379_03945 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EJ379_03965 ENOG4105C5Y PTS System EJ379_03980 ENOG4105K63 Thioredoxin EJ379_04000 ENOG4108B31 Spore germination protein EJ379_04020 ENOG4107Y03 Nitroreductase EJ379_04025 ENOG4105ED1 spovr family EJ379_04035 ENOG4108TCS Glutamyl endopeptidase EJ379_04045 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase EJ379_04050 ENOG4105XTG Pfam:DUF156 EJ379_04055 ENOG4105VFE sira family EJ379_04060 ENOG4107TPS domain protein EJ379_04065 ENOG4105VFE sira family EJ379_04070 ENOG4105VFE sira family EJ379_04075 ENOG41085GJ domain protein EJ379_04080 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase EJ379_04085 ENOG41087NI Sulfite exporter TauE/SafE EJ379_04095 ENOG4108KGH TRANSCRIPTIONal EJ379_04125 ENOG4105EMD TRANSCRIPTIONal EJ379_04130 ENOG4105VCP PTS System EJ379_04135 ENOG4105VZJ PTS System EJ379_04160 ENOG41069ER domain protein EJ379_04165 ENOG4107RBB ABC transporter, permease EJ379_04170 ENOG4105C19 ABC transporter EJ379_04200 ENOG4105WEF catalase EJ379_04235 ENOG4107T5V SNARE associated Golgi EJ379_04270 ENOG4107RWR Sodium hydrogen exchanger EJ379_04280 ENOG4106KNT transcriptional regulator EJ379_04285 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EJ379_04320 ENOG4108YXU transcriptional regulator AsnC family EJ379_04325 ENOG4105CH7 arginosuccinase EJ379_04330 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EJ379_04375 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) EJ379_04380 ENOG4105E5W Transporter EJ379_04390 ENOG4107RKG DJ-1/PfpI family EJ379_04395 ENOG4105CH6 catalase EJ379_04405 ENOG4105D5Q Arginine ornithine antiporter EJ379_04410 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EJ379_04420 ENOG4105C26 Dehydrogenase EJ379_04435 ENOG4105BZ1 (ABC) transporter EJ379_04440 ENOG4105BZ1 (ABC) transporter EJ379_04455 ENOG4105DRP amino acid AbC transporter EJ379_04460 ENOG4105CDA abc transporter atp-binding protein EJ379_04475 ENOG410839P EJ379_04485 ENOG4108UH6 UPF0754 membrane protein EJ379_04495 ENOG4105BZU Histidine kinase EJ379_04500 ENOG4105WH1 Two component transcriptional regulator luxr family EJ379_04510 ENOG4107FQX Alpha-acetolactate decarboxylase EJ379_04520 ENOG4108VX5 3-methyladenine DNA glycosylase EJ379_04535 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EJ379_04540 ENOG4105D4P Coproporphyrinogen iii oxidase EJ379_04545 ENOG4105CEY Amp-dependent synthetase and ligase EJ379_04560 ENOG4105CHH sulfate transporter EJ379_04585 ENOG4105CGU Enoyl-CoA hydratase EJ379_04605 ENOG4105DER m42 family EJ379_04625 ENOG4105CTU Proline racemase EJ379_04630 ENOG4105CIF Ornithine Cyclodeaminase EJ379_04645 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ379_04655 ENOG4108JQ7 (ABC) transporter EJ379_04705 ENOG4108IBT Inherit from COG: transposase EJ379_04775 ENOG4105CSH Transporter EJ379_04785 ENOG4108MRH transcriptional regulatory protein EJ379_04890 ENOG4105CDU Replicative dna helicase EJ379_04910 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJ379_04925 ENOG4105D9U N-acetyltransferase EJ379_04950 ENOG4105F6J Alpha beta hydrolase fold EJ379_04990 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EJ379_05005 ENOG4105CMT Dihydroxyacetone kinase EJ379_05020 ENOG4105CMT Dihydroxyacetone kinase EJ379_05130 ENOG4105WN5 stage II sporulation protein EJ379_05140 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ379_05150 ENOG4108MJI response regulator EJ379_05155 ENOG4105BZU Histidine kinase EJ379_05160 ENOG4105BZU Histidine kinase EJ379_05200 ENOG4107QHE Choloylglycine hydrolase EJ379_05220 ENOG4107VRP DNA repair exonuclease EJ379_05225 ENOG4106D4I domain protein EJ379_05240 ENOG410829K Lysine exporter protein (Lyse ygga) EJ379_05260 ENOG4108MUZ hydrolase EJ379_05285 ENOG4105F0F Oxalate decarboxylase EJ379_05290 ENOG41067QW Transcriptional regulator EJ379_05295 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator EJ379_05310 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EJ379_05330 ENOG4105EEM helicase EJ379_05340 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EJ379_05370 ENOG4105K59 histidine triad (HIT) protein EJ379_05400 ENOG410905X membrane-flanked domain protein EJ379_05405 ENOG4105CKV Membrane EJ379_05445 ENOG410905X membrane-flanked domain protein EJ379_05450 ENOG4105CKV Membrane EJ379_05455 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation EJ379_05460 ENOG4105BZ4 penicillin-binding protein EJ379_05470 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EJ379_05475 ENOG4105C1Q protoporphyrinogen oxidase EJ379_05500 ENOG4105NA0 Transcriptional regulator EJ379_05515 ENOG4105ECB domain protein EJ379_05535 ENOG4108MK9 spermidine N(1)-acetyltransferase EJ379_05545 ENOG4106AXD EJ379_05550 ENOG4108RQ5 Beta-lactamase domain-containing protein EJ379_05555 ENOG4105DF9 Lipoate-protein, ligase EJ379_05565 ENOG4105CEY Amp-dependent synthetase and ligase EJ379_05575 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EJ379_05580 ENOG4108I5D sulfate abc transporter EJ379_05585 ENOG4105ECW sulfate abc transporter EJ379_05590 ENOG4108IJ6 ABC transporter EJ379_05700 ENOG4107RN3 metallophosphoesterase EJ379_05705 ENOG4107TVP HD domain protein EJ379_05715 ENOG4108AEY RNA polymerase sigma factor EJ379_05720 ENOG41086D8 Transcriptional regulator EJ379_05735 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EJ379_05755 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 EJ379_05760 ENOG4105C8Q Methyl-accepting chemotaxis EJ379_05765 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) EJ379_05775 ENOG4107QP3 malate synthase g EJ379_05825 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination EJ379_05830 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation EJ379_05875 ENOG4105ERH Fumarylacetoacetate hydrolase EJ379_05885 ENOG4105C8Y Acetylornithine aminotransferase EJ379_05900 ENOG4105CAQ asparagine synthetase EJ379_05905 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EJ379_05910 ENOG4105CH6 catalase EJ379_05915 ENOG4105BZU Histidine kinase EJ379_05940 ENOG4105QNR S1 RNA binding domain protein EJ379_05945 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EJ379_05955 ENOG4107AYK membrAne EJ379_05960 ENOG41073B9 EJ379_05970 ENOG4108KP7 hydrolase EJ379_05980 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EJ379_06005 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EJ379_06010 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EJ379_06025 ENOG4105C31 Tryptophanyl-tRNA synthetase EJ379_06045 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EJ379_06050 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ379_06060 ENOG4108JQ7 (ABC) transporter EJ379_06065 ENOG4105UQX Mate efflux family protein EJ379_06085 ENOG4108ZCF integral membrane protein EJ379_06095 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EJ379_06105 ENOG4105DPN Oligoendopeptidase f EJ379_06115 ENOG4108Z18 K06886 hemoglobin EJ379_06120 ENOG4105MIX Adenylate cyclase EJ379_06135 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EJ379_06140 ENOG4105EMS pseudouridine synthase EJ379_06160 ENOG4105K64 Glycosyl transferase, family 2 EJ379_06180 ENOG4107TVC Glycosyl transferase, family 2 EJ379_06200 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) EJ379_06205 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase EJ379_06215 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase EJ379_06290 ENOG4105CK7 Sodium proline symporter EJ379_06305 ENOG4105DDQ anthranilate synthase EJ379_06310 ENOG4108I0Q anthranilate phosphoribosyltransferase EJ379_06315 ENOG4105DK0 Indole-3-glycerol phosphate synthase EJ379_06320 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase EJ379_06325 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EJ379_06330 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) EJ379_06395 ENOG4105C7S Dehydrogenase EJ379_06400 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EJ379_06405 ENOG4105VZ8 Transcriptional regulator EJ379_06455 ENOG4108NE4 EJ379_06490 ENOG4105VTR Integrase EJ379_06520 ENOG4105DZ1 carboxypeptidase EJ379_06525 ENOG4105VFR signal peptidase EJ379_06560 ENOG4105C26 Dehydrogenase EJ379_06565 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJ379_06570 ENOG4105F38 ABC transporter, permease EJ379_06575 ENOG4105D38 putrescine abc transporter EJ379_06580 ENOG4108HM4 ABC transporter EJ379_06590 ENOG4105EYF MMPL domain protein EJ379_06600 ENOG4108YBP pseudouridine synthase EJ379_06610 ENOG4105K4I Scp-like extracellular EJ379_06615 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EJ379_06620 ENOG4105CQB FAD linked oxidase domain protein EJ379_06635 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_06640 ENOG4105BZU Histidine kinase EJ379_06645 ENOG4105JXH GntR family transcriptional regulator EJ379_06665 ENOG4106A3R peptidase EJ379_06675 ENOG4108QTI )-transporter EJ379_06680 ENOG4107TS3 membrane protein, TerC EJ379_06685 ENOG4105CZN Potassium uptake protein EJ379_06690 ENOG410681C small acid-soluble spore protein EJ379_06695 ENOG4108Z7G MaoC domain protein dehydratase EJ379_06715 ENOG4105CHR reductase EJ379_06745 ENOG4105C4Y ABC transporter EJ379_06750 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJ379_06755 ENOG4107RCV ABC transporter, permease EJ379_06775 ENOG4105E98 transcriptional regulator DeoR family EJ379_06795 ENOG4105PXI polysaccharide deacetylase EJ379_06805 ENOG4105BZU Histidine kinase EJ379_06810 ENOG41090MY MarR family Transcriptional regulator EJ379_06820 ENOG4106DF1 EJ379_06825 ENOG4105BZU Histidine kinase EJ379_06830 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EJ379_06835 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase EJ379_06840 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EJ379_06885 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) EJ379_06890 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EJ379_06895 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EJ379_06900 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family EJ379_06905 ENOG4105CZV ABC transporter EJ379_06915 ENOG4105CJ1 ABC, transporter EJ379_06955 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EJ379_06960 ENOG4105EA8 2-Nitropropane dioxygenase EJ379_06965 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD EJ379_06975 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein EJ379_06995 ENOG4105NQC Flavodoxin EJ379_07025 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EJ379_07055 ENOG4105CZN Potassium uptake protein EJ379_07060 ENOG41063Y9 EJ379_07065 ENOG4105KBJ sporulation protein ytfj EJ379_07085 ENOG4105CM2 brancheD-chain amino acid aminotransferase EJ379_07090 ENOG4105C7K acetolactate synthase EJ379_07095 ENOG4108ZP8 Acetolactate synthase small subunit EJ379_07100 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EJ379_07115 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EJ379_07125 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) EJ379_07130 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EJ379_07135 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EJ379_07140 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EJ379_07145 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EJ379_07150 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EJ379_07155 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EJ379_07160 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EJ379_07165 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase EJ379_07170 ENOG4107RVV histidinol phosphate phosphatase, hisj family EJ379_07185 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EJ379_07190 ENOG4105E0M Sulfatase EJ379_07200 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EJ379_07215 ENOG4107S4M Sulfate adenylate transferase EJ379_07220 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) EJ379_07225 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) EJ379_07235 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EJ379_07240 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein EJ379_07245 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein EJ379_07250 ENOG4105C8J )-transporter EJ379_07270 ENOG4105DFD Na H antiporter EJ379_07290 ENOG4105ENE Histidine kinase EJ379_07295 ENOG4105WH1 Two component transcriptional regulator luxr family EJ379_07315 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJ379_07340 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EJ379_07360 ENOG4105CJ3 phosphate transporter EJ379_07365 ENOG4107GRR phosphate transport regulator EJ379_07370 ENOG4105BZ4 penicillin-binding protein EJ379_07385 ENOG4105BZU Histidine kinase EJ379_07390 ENOG4105I3N Conserved Protein EJ379_07405 ENOG4105BZU Histidine kinase EJ379_07410 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EJ379_07435 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EJ379_07440 ENOG4105DZ1 carboxypeptidase EJ379_07445 ENOG4108JIC nucleoside recognition domain protein EJ379_07455 ENOG4105FE9 pseudouridine synthase EJ379_07460 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EJ379_07465 ENOG4107TWT Cytochrome c biogenesis protein EJ379_07470 ENOG4105CRE cytochrome C EJ379_07475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_07480 ENOG4105BZU Histidine kinase EJ379_07485 ENOG4108WBT adenosyltransferase EJ379_07500 ENOG4108SAX Membrane EJ379_07515 ENOG4105C9U ATP-dependent DNA helicase RecQ EJ379_07520 ENOG4105I7S Abortive infection protein EJ379_07530 ENOG4107RGJ metallophosphoesterase EJ379_07535 ENOG4108XDN Transcriptional regulator EJ379_07540 ENOG4108S6Z Negative regulator of genetic competence EJ379_07565 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase EJ379_07570 ENOG4107RB3 L-asparaginase EJ379_07585 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) EJ379_07600 ENOG4105S2F EJ379_07605 ENOG41065D1 EJ379_07635 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) EJ379_07650 ENOG4105XXQ heptaprenyl diphosphate synthase component I EJ379_07660 ENOG4105EAH synthase EJ379_07665 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EJ379_07670 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EJ379_07675 ENOG4105D49 3-dehydroquinate synthase EJ379_07685 ENOG41068YB TPR repeat-containing protein EJ379_07700 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) EJ379_07705 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EJ379_07740 ENOG4108JYZ YitT family EJ379_07750 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase EJ379_07755 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EJ379_07765 ENOG4105FJR Lmbe family EJ379_07770 ENOG4105CPK Glycosyl transferase (Group 1 EJ379_07790 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EJ379_07795 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) EJ379_07805 ENOG4105DVT helicase EJ379_07810 ENOG4105YAC EJ379_07830 ENOG4105CSM endonuclease III EJ379_07900 ENOG4106F55 Protein of unknown function (DUF1273) EJ379_07915 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EJ379_07925 ENOG4105DVT helicase EJ379_07930 ENOG4105CTD carboxy-peptidase EJ379_07940 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EJ379_07945 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) EJ379_07950 ENOG4105C2W permease EJ379_07955 ENOG4105DHF Membrane EJ379_07960 ENOG410890F Dynamin family EJ379_07970 ENOG4108W0I acetyltransferase EJ379_07980 ENOG4105KHC sulfurtransferase EJ379_08035 ENOG4105HTX biosynthesis protein EJ379_08065 ENOG4105CPK Glycosyl transferase (Group 1 EJ379_08080 ENOG4108SZE gCN5-related N-acetyltransferase EJ379_08100 ENOG41081VK Ribonuclease EJ379_08165 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EJ379_08175 ENOG4107RWR Sodium hydrogen exchanger EJ379_08180 ENOG4105CN5 Metallo-Beta-Lactamase EJ379_08185 ENOG4108Z5V transcriptional regulator, merr family EJ379_08195 ENOG4105H67 Protein of unknown function (DUF421) EJ379_08200 ENOG41080C8 DUF218 domain EJ379_08235 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EJ379_08245 ENOG4107R0U MotA TolQ exbB proton channel EJ379_08250 ENOG4105ER2 Ompa motb domain protein EJ379_08255 ENOG4107YTP response regulator receiver protein EJ379_08260 ENOG4105CBS Chea signal transduction histidine kinase EJ379_08265 ENOG4105DD5 Flagellar motor switch protein EJ379_08280 ENOG4105BZU Histidine kinase EJ379_08300 ENOG4105E1Q flagellar hook-associated protein EJ379_08305 ENOG4105DTJ flagellar hook-associated protein EJ379_08310 ENOG4107TPX flagellar hook-associated EJ379_08325 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EJ379_08330 ENOG4108ZC9 flagellar basal-body rod protein flgc EJ379_08340 ENOG4107U2N Flagellar M-ring protein EJ379_08345 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EJ379_08375 ENOG4105BZE flagellar hook protein, FlgE EJ379_08390 ENOG4107R88 Chemotaxis protein (CheV) EJ379_08405 ENOG4105I03 Flagellin EJ379_08410 ENOG4105I03 Flagellin EJ379_08415 ENOG4105I03 Flagellin EJ379_08420 ENOG4105I03 Flagellin EJ379_08425 ENOG4105E4C Lytic transglycosylase catalytic EJ379_08435 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EJ379_08440 ENOG4105DD5 Flagellar motor switch protein EJ379_08450 ENOG4105CN7 Flagellar biosynthetic protein FliP EJ379_08455 ENOG4105VS8 Flagellar biosynthetic protein fliq EJ379_08465 ENOG4105D00 flagellar biosynthetic protein flhB EJ379_08470 ENOG4105D7B Flagellar biosynthesis protein flha EJ379_08475 ENOG4105FZW flagellar biosynthesis regulator FlhF EJ379_08480 ENOG4105KTQ flagellar basal-body rod protein EJ379_08485 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EJ379_08520 ENOG4105KAC Antibiotic biosynthesis monooxygenase EJ379_08560 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component EJ379_08595 ENOG4105CVJ phosphoglycerate mutase EJ379_08605 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EJ379_08625 ENOG4105CAQ asparagine synthetase EJ379_08645 ENOG4105PGM cation diffusion facilitator family transporter EJ379_08655 ENOG4105DRR Transcriptional regulator, GntR family EJ379_08660 ENOG4108UZ3 Transporter EJ379_08670 ENOG4105CKI cobalamin synthesis protein EJ379_08675 ENOG4108PJD permease EJ379_08690 ENOG4105DFD Na H antiporter EJ379_08695 ENOG4105VUF Transcriptional regulator EJ379_08705 ENOG4105C9Q fumarate hydratase class II EJ379_08720 ENOG4107QJQ Mate efflux family protein EJ379_08725 ENOG4105EC3 peptidase S51, dipeptidase E EJ379_08745 ENOG4107QIV Cytochrome c biogenesis protein EJ379_08765 ENOG4105BZC d-serine deaminase EJ379_08770 ENOG4106BRA Membrane EJ379_08810 ENOG4105CJ1 ABC, transporter EJ379_08830 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) EJ379_08840 ENOG4108IJ0 Aspartate ammonia-lyase EJ379_08845 ENOG4105C6K Malic enzyme EJ379_08905 ENOG4105FVX EJ379_08910 ENOG4105E09 nadh pyrophosphatase EJ379_08925 ENOG4105CSR polyphosphate kinase 2 EJ379_08930 ENOG4105U3E Transcriptional regulator EJ379_08945 ENOG4105DXI Major Facilitator superfamily EJ379_08955 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EJ379_08960 ENOG4105EU0 Major facilitator Superfamily EJ379_08965 ENOG4105C6T cysteine synthase EJ379_08985 ENOG4105C8J )-transporter EJ379_08995 ENOG4105X5K response regulator receiver protein EJ379_09000 ENOG4105H67 Protein of unknown function (DUF421) EJ379_09020 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EJ379_09025 ENOG4105CHR reductase EJ379_09030 ENOG4105CM2 brancheD-chain amino acid aminotransferase EJ379_09035 ENOG4105C7K acetolactate synthase EJ379_09045 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EJ379_09050 ENOG4105C01 Dihydroxy-acid dehydratase EJ379_09055 ENOG4105C7B Threonine dehydratase EJ379_09080 ENOG4105C6X Major Facilitator EJ379_09085 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EJ379_09095 ENOG4105DY9 regulatoR EJ379_09100 ENOG4105CYC Transferase EJ379_09115 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJ379_09145 ENOG41068WN EJ379_09165 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) EJ379_09180 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EJ379_09185 ENOG4105C0X amino acid EJ379_09220 ENOG410849A acetyltransferase, (GNAT) family EJ379_09230 ENOG4105K8R UPF0145 protein EJ379_09245 ENOG4107RHR regulatoR EJ379_09255 ENOG4105D9N nucleoside EJ379_09260 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) EJ379_09285 ENOG4107RAQ aminopeptidase EJ379_09295 ENOG4107R16 Multicopper oxidase EJ379_09340 ENOG4108T5E Copper resistance protein EJ379_09345 ENOG4105KTB nuclear export factor GLE1 EJ379_09350 ENOG4107RT3 EamA-like transporter family EJ379_09355 ENOG4105GZI Transcriptional regulator EJ379_09360 ENOG4108Z40 Transcriptional regulator EJ379_09365 ENOG4107ZXU DSBA oxidoreductase EJ379_09370 ENOG4108TVJ Nitroreductase EJ379_09375 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EJ379_09465 ENOG4105C2M dna polymerase I EJ379_09570 ENOG4105KRN Transcriptional regulator, abrb family EJ379_09705 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis EJ379_09785 ENOG4106F5Q Membrane EJ379_09790 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EJ379_09805 ENOG4105CKI cobalamin synthesis protein EJ379_09815 ENOG4105C0Z ABC transporter EJ379_09820 ENOG4108IV0 ABC, transporter EJ379_09825 ENOG4105C32 Amino acid ABC transporter (Permease) EJ379_09835 ENOG4105SKE transcriptional Regulator LysR family EJ379_09855 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes EJ379_09865 ENOG4105C4M (Ubiquinol oxidase) subunit I EJ379_09870 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EJ379_09875 ENOG4108JJ9 ABC, transporter EJ379_09880 ENOG4108JJ8 (ABC) transporter EJ379_09890 ENOG4105K64 Glycosyl transferase, family 2 EJ379_09900 ENOG4108UT6 Transferase hexapeptide repeat containing protein EJ379_09955 ENOG4105BZ1 (ABC) transporter EJ379_09960 ENOG4105EFI regulatoR EJ379_09965 ENOG4105BZU Histidine kinase EJ379_09975 ENOG41075D4 Aminoglycoside 6-adenylyltransferase EJ379_10000 ENOG4105D6E homoserine dehydrogenase EJ379_10010 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) EJ379_10025 ENOG4108KGH TRANSCRIPTIONal EJ379_10035 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EJ379_10040 ENOG4105BZU Histidine kinase EJ379_10055 ENOG4105KT7 mgtC SapB transporter EJ379_10060 ENOG4105VRR gCN5-related N-acetyltransferase EJ379_10070 ENOG4105DUU IucA IucC family protein EJ379_10075 ENOG4105CEY Amp-dependent synthetase and ligase EJ379_10090 ENOG4108WBH protein TIM barrel EJ379_10095 ENOG4105YWU small acid-soluble spore protein EJ379_10105 ENOG4108ZUB Lysine exporter protein (Lyse ygga) EJ379_10110 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJ379_10160 ENOG4105KRN Transcriptional regulator, abrb family EJ379_10170 ENOG4105YVS arsR family transcriptional regulator EJ379_10175 ENOG4105CPC Aldo Keto reductase EJ379_10180 ENOG4107XZQ multidrug resistance protein EJ379_10190 ENOG4105KAF membrAne EJ379_10215 ENOG4105C8Q Methyl-accepting chemotaxis EJ379_10230 ENOG4108K88 Membrane EJ379_10235 ENOG4108WPJ Ferritin-like domain EJ379_10250 ENOG4105DEN Luciferase family EJ379_10265 ENOG4105VMI -acetyltransferase EJ379_10270 ENOG4107QM2 Aldo Keto reductase EJ379_10275 ENOG4105CKI cobalamin synthesis protein EJ379_10285 ENOG4105DSE periplasmic solute binding protein EJ379_10290 ENOG4105K4T epimerase EJ379_10295 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EJ379_10300 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EJ379_10345 ENOG4107T5V SNARE associated Golgi EJ379_10360 ENOG4108PJD permease EJ379_10370 ENOG4108S4H thioesterase Superfamily protein EJ379_10380 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EJ379_10400 ENOG4105SXS Protein of unknown function (DUF456) EJ379_10405 ENOG4105C37 (CBS) domain EJ379_10425 ENOG4108Z7R Chaperone CsaA EJ379_10445 ENOG4108ZRV stage ii sporulation protein p EJ379_10455 ENOG4108VXD carboxy-peptidase EJ379_10465 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EJ379_10485 ENOG4108ZRV stage ii sporulation protein p EJ379_10495 ENOG4108X4Q Hydrolase EJ379_10510 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EJ379_10530 ENOG41087PP glycosyltransferase MGT family EJ379_10535 ENOG4108JYZ YitT family EJ379_10540 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJ379_10570 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EJ379_10605 ENOG4108MGT Required for secretion of EsxA and EsxB EJ379_10695 ENOG4105KBJ sporulation protein ytfj EJ379_10720 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJ379_10725 ENOG4105CKU formyltetrahydrofolate synthetase EJ379_10740 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) EJ379_10745 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily EJ379_10755 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EJ379_10760 ENOG4105EMN RNA polymerase sigma factor EJ379_10770 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) EJ379_10780 ENOG4105CNW domain protein EJ379_10790 ENOG4108V06 Glutathione peroxidase EJ379_10805 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EJ379_10815 ENOG4108IUE nitrate reductase beta subunit EJ379_10820 ENOG4105R3A Nitrate reductase EJ379_10830 ENOG4107V6Q Cyclic nucleotide-binding domain EJ379_10835 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EJ379_10840 ENOG4105D06 uba thif-type nad fad binding protein EJ379_10845 ENOG4105CVM Molybdenum cofactor synthesis domain protein EJ379_10850 ENOG4108ZAF Molybdopterin EJ379_10885 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein EJ379_10890 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein EJ379_10895 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EJ379_10900 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit EJ379_10905 ENOG4108IFG nitrite reductase, (NAD(P)H) EJ379_10910 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) EJ379_10945 ENOG4105MCT stage V sporulation protein S EJ379_10990 ENOG4105C5H ABC transporter EJ379_11005 ENOG4108UUM single-stranded DNA-binding protein EJ379_11025 ENOG4107YX5 Pfam:DUF548 EJ379_11030 ENOG4105C75 arginyL-tRNA synthetase EJ379_11060 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EJ379_11090 ENOG4105C5S asparaginyl-tRNA synthetase EJ379_11095 ENOG4105C8J )-transporter EJ379_11115 ENOG4107XGZ Hydrolase EJ379_11120 ENOG4105CY2 Citrate transporter EJ379_11140 ENOG4105KD7 acetyltransferase EJ379_11150 ENOG4105VMP Transcriptional regulator EJ379_11155 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase EJ379_11180 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 EJ379_11195 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) EJ379_11200 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) EJ379_11210 ENOG4107RVG penicillin-binding protein EJ379_11215 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EJ379_11220 ENOG4105E9Q Acyl-transferase EJ379_11225 ENOG4108UT2 hemolysin iii EJ379_11235 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EJ379_11245 ENOG4108RCR degv family EJ379_11255 ENOG4108KF3 Electron transport protein SCO1 SenC EJ379_11260 ENOG4107Y70 Heat shock protein EJ379_11265 ENOG4105CAQ asparagine synthetase EJ379_11280 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EJ379_11285 ENOG4108MES Periplasmic binding protein EJ379_11290 ENOG4105F0I Aminotransferase EJ379_11325 ENOG4105D8X mechanosensitive ion channel EJ379_11330 ENOG4105BZU Histidine kinase EJ379_11335 ENOG4105WH1 Two component transcriptional regulator luxr family EJ379_11340 ENOG4106KNT transcriptional regulator EJ379_11345 ENOG4107ZY0 Phenazine biosynthesis-like protein EJ379_11365 ENOG4105CMG Carbohydrate kinase EJ379_11370 ENOG4105C6Z Gluconate EJ379_11380 ENOG4108YV3 Protein of unknown function (DUF2711) EJ379_11410 ENOG4108IJ8 ABC transporter EJ379_11415 ENOG4105E90 ABC transporter EJ379_11450 ENOG4105C37 (CBS) domain EJ379_11475 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EJ379_11490 ENOG4107S4Y M20 DapE family protein YgeY EJ379_11495 ENOG4108TSC N-acetyltransferase EJ379_11500 ENOG4108JUB Transcriptional regulator EJ379_11505 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EJ379_11550 ENOG410841Q phosphoesterase PA-phosphatase related protein EJ379_11560 ENOG4105SZ6 Thioredoxin EJ379_11565 ENOG4105KNA -acetyltransferase EJ379_11610 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EJ379_11665 ENOG4105BZ4 penicillin-binding protein EJ379_11675 ENOG4105CZM Major Facilitator EJ379_11680 ENOG4105W8X HesB YadR YfhF-family protein EJ379_11690 ENOG4105DXD 2-methylcitrate dehydratase EJ379_11695 ENOG4105CR4 methylisocitrate lyase EJ379_11700 ENOG4105C1G acyl-Coa dehydrogenase EJ379_11705 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EJ379_11715 ENOG4105N14 lysine exporter protein LysE YggA EJ379_11720 ENOG4105E39 Enoyl-CoA hydratase EJ379_11735 ENOG4107RFY SbcCD D subunit EJ379_11740 ENOG4105EYH Exonuclease EJ379_11760 ENOG4105FCD Major Facilitator EJ379_11770 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EJ379_11775 ENOG4105E4F Isochorismate synthase EJ379_11780 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EJ379_11785 ENOG4105WQI isochorismatase EJ379_11790 ENOG4105CEY Amp-dependent synthetase and ligase EJ379_11795 ENOG4105WQT MbtH domain protein EJ379_11800 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJ379_11815 ENOG4105K70 DNA-binding protein EJ379_11835 ENOG4105BZG amino acid carrier protein EJ379_11855 ENOG4105FE9 pseudouridine synthase EJ379_11860 ENOG4105C22 threonyL-tRNA synthetase EJ379_11865 ENOG4105C19 ABC transporter EJ379_11900 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EJ379_11915 ENOG41081I9 integral membrane protein EJ379_11925 ENOG4108Y4K DNA-binding transcriptional activator EJ379_11945 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EJ379_11955 ENOG4105EYF MMPL domain protein EJ379_11995 ENOG4105WCN acetyltransferase EJ379_12020 ENOG4105C1Q protoporphyrinogen oxidase EJ379_12030 ENOG41068WN EJ379_12060 ENOG4107V2S Transcriptional regulator EJ379_12065 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EJ379_12085 ENOG4105DND Transcriptional regulator EJ379_12090 ENOG4108RPX mosc domain containing protein EJ379_12105 ENOG4105BZ1 (ABC) transporter EJ379_12110 ENOG4105BZ1 (ABC) transporter EJ379_12145 ENOG4108JCI Transcriptional regulator EJ379_12175 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) EJ379_12180 ENOG4108KPJ rna polymerase sigma factor EJ379_12205 ENOG4105F32 YngK protein EJ379_12225 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) EJ379_12230 ENOG4105RD7 BadF BadG BcrA BcrD EJ379_12235 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EJ379_12240 ENOG4107STF Involved in phosphonate degradation (By similarity) EJ379_12250 ENOG4108INS Transcriptional regulator EJ379_12270 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EJ379_12280 ENOG4105C1J atp-dependent rna helicase EJ379_12295 ENOG4108RZE Tetr family transcriptional regulator EJ379_12420 ENOG41088CC tellurite resistance protein tehB EJ379_12430 ENOG4108I0C methyltransferase EJ379_12435 ENOG4107RA9 decarboxylase EJ379_12440 ENOG4105K56 Transcriptional regulator EJ379_12445 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EJ379_12470 ENOG4105CIN aminoacyl-histidine dipeptidase EJ379_12495 ENOG4105KRN Transcriptional regulator, abrb family EJ379_12505 ENOG4105EJ9 Membrane EJ379_12510 ENOG4105EQK -acetyltransferase EJ379_12550 ENOG4105W8Z 4'-phosphopantetheinyl transferase EJ379_12620 ENOG4105FQP Beta-lactamase EJ379_12625 ENOG4107RVG penicillin-binding protein EJ379_12640 ENOG4107RF6 penicillin-binding protein EJ379_12645 ENOG4107RF6 penicillin-binding protein EJ379_12655 ENOG4108MK9 spermidine N(1)-acetyltransferase EJ379_12665 ENOG4105DIN metallophosphoesterase EJ379_12675 ENOG4105CJ1 ABC, transporter EJ379_12685 ENOG4107Z3H Transcriptional regulator, TetR family EJ379_12700 ENOG4105C1G acyl-Coa dehydrogenase EJ379_12705 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EJ379_12710 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit EJ379_12715 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EJ379_12720 ENOG4105E39 Enoyl-CoA hydratase EJ379_12725 ENOG4107QX3 carboxylase EJ379_12730 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJ379_12775 ENOG4105DZ1 carboxypeptidase EJ379_12790 ENOG4105T9C HD domain EJ379_12800 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EJ379_12820 ENOG41075H3 AraC family transcriptional regulator EJ379_12850 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EJ379_12860 ENOG4107Y80 Major Facilitator superfamily EJ379_12865 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EJ379_12870 ENOG4105KVH Transcriptional regulator EJ379_12940 ENOG4105CPQ Dehydrogenase EJ379_12950 ENOG410900G Protein of unknown function (DUF421) EJ379_12955 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EJ379_12965 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein EJ379_12975 ENOG4105DK7 lysyl-tRNA synthetase EJ379_13040 ENOG4105D6E homoserine dehydrogenase EJ379_13050 ENOG4105CPF Cell wall formation (By similarity) EJ379_13055 ENOG4105ETU transcriptional activator (TenA EJ379_13085 ENOG4105VTR Integrase EJ379_13295 ENOG4105XSJ toxin secretion phage lysis holin EJ379_13370 ENOG4106A3M Cytochrome p-450 EJ379_13395 ENOG410667J hydrolase EJ379_13400 ENOG4105BZU Histidine kinase EJ379_13405 ENOG4107RF6 penicillin-binding protein EJ379_13430 ENOG4108FPN Integrase EJ379_13450 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EJ379_13465 ENOG41086D8 Transcriptional regulator EJ379_13500 ENOG4108NHD germination protein EJ379_13515 ENOG4108W2Y isochorismatase EJ379_13535 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EJ379_13545 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EJ379_13555 ENOG4105EKQ RNA-directed DNA polymerase EJ379_13605 ENOG4108JJB ABC transporter EJ379_13620 ENOG4108HGU Histidine kinase EJ379_13635 ENOG4105CB2 alcohol dehydrogenase EJ379_13640 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EJ379_13645 ENOG4105CJN penicillin-binding protein EJ379_13685 ENOG4108V4B ThiJ pfpI EJ379_13695 ENOG4107Y80 Major Facilitator superfamily EJ379_13710 ENOG4107VXM glycerophosphoryl diester phosphodiesterase EJ379_13735 ENOG4107Y9U Membrane EJ379_13775 ENOG4105FCD Major Facilitator EJ379_13790 ENOG4105E09 nadh pyrophosphatase EJ379_13795 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EJ379_13815 ENOG4105KME endoribonuclease L-psp EJ379_13820 ENOG4108XI2 Domain of unknown function (DUF1963) EJ379_13840 ENOG4108NRW Phospholipase, patatin family EJ379_13845 ENOG4105KWG Pfam:DUF1696 EJ379_13870 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EJ379_13880 ENOG4105PKS Excinuclease abc c subunit domain protein EJ379_13910 ENOG4105CJ1 ABC, transporter EJ379_13930 ENOG4107VFR oxidoreductase EJ379_13985 ENOG4108IUM Glycogen debranching enzyme EJ379_13995 ENOG4105CGH 5'-nucleotidase EJ379_14015 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) EJ379_14020 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EJ379_14025 ENOG4105FDR Membrane EJ379_14035 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EJ379_14080 ENOG4105MSI germination protein ypeb EJ379_14110 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) EJ379_14115 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) EJ379_14120 ENOG4107Z3H Transcriptional regulator, TetR family EJ379_14155 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EJ379_14170 ENOG4105E98 transcriptional regulator DeoR family EJ379_14185 ENOG41062ES Transcriptional regulator EJ379_14205 ENOG4107QKR Dehydrogenase EJ379_14215 ENOG4107RUY (E1 component), alpha subunit EJ379_14225 ENOG4105E1F short-chain dehydrogenase reductase EJ379_14230 ENOG4105RHY Pfam:UPF0157 EJ379_14270 ENOG4107SQ8 Glycine betaine EJ379_14275 ENOG4108IJ7 Glycine betaine EJ379_14285 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EJ379_14300 ENOG4105E66 phosphoriboisomerase A EJ379_14305 ENOG41082BV acetyltransferase EJ379_14310 ENOG4108M1A Chitin-binding protein EJ379_14335 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EJ379_14340 ENOG4105MSB protein, conserved in bacteria EJ379_14365 ENOG4108Z7F N-acetyltransferase EJ379_14385 ENOG4105EEM helicase EJ379_14400 ENOG4105C9U ATP-dependent DNA helicase RecQ EJ379_14455 ENOG4108M1A Chitin-binding protein EJ379_14475 ENOG4105BZG amino acid carrier protein EJ379_14480 ENOG4105C26 Dehydrogenase EJ379_14485 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EJ379_14490 ENOG4105CTU Proline racemase EJ379_14495 ENOG4105CTU Proline racemase EJ379_14500 ENOG41080HI glycine oxidase EJ379_14510 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein EJ379_14540 ENOG4107T5V SNARE associated Golgi EJ379_14550 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD EJ379_14570 ENOG4105DTQ mandelate racemase muconate lactonizing EJ379_14585 ENOG4107SET aldo keto reductase EJ379_14620 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) EJ379_14625 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EJ379_14630 ENOG4105BZU Histidine kinase EJ379_14635 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_14655 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 EJ379_14670 ENOG4105DPN Oligoendopeptidase f EJ379_14675 ENOG4105EPR degv family EJ379_14735 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) EJ379_14740 ENOG4106K7D Major facilitator family transporter EJ379_14760 ENOG4107BMA Transglycosylase associated protein EJ379_14775 ENOG41089UC methyltransferase, type 11 EJ379_14810 ENOG4105CHM Aminotransferase EJ379_14840 ENOG4105DVE abc transporter atp-binding protein EJ379_14890 ENOG4105C02 permease EJ379_14900 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EJ379_14905 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EJ379_14910 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein EJ379_14915 ENOG4105D7T ABC transporter EJ379_14950 ENOG4108AQF aminoglycoside N(3)-acetyltransferase EJ379_14990 ENOG4107VC0 DNA alkylation repair enzyme EJ379_14995 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase EJ379_15015 ENOG4108ZCF integral membrane protein EJ379_15020 ENOG4105E0M Sulfatase EJ379_15025 ENOG4105C5H ABC transporter EJ379_15035 ENOG4105EYF MMPL domain protein EJ379_15040 ENOG41082JN Transcriptional regulator EJ379_15060 ENOG4105CIH Imidazole acetol-phosphate transaminase EJ379_15065 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EJ379_15070 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EJ379_15095 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) EJ379_15115 ENOG41069ER domain protein EJ379_15125 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase EJ379_15155 ENOG4105D4B ABC, transporter EJ379_15160 ENOG4105F5R ABC transporter EJ379_15165 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane EJ379_15175 ENOG4105DKT Transcriptional regulator EJ379_15180 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) EJ379_15190 ENOG41061GT Aldolase EJ379_15200 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) EJ379_15230 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EJ379_15235 ENOG4105II7 pyrroline-5-carboxylate reductase EJ379_15245 ENOG4107258 Transcriptional regulator EJ379_15265 ENOG4105ECK Fatty Acid Desaturase EJ379_15275 ENOG4107RBI VanW family EJ379_15280 ENOG4105G6Z alkaline phosphatase EJ379_15290 ENOG4105VMP Transcriptional regulator EJ379_15310 ENOG41068WN EJ379_15345 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EJ379_15360 ENOG4105CSH Transporter EJ379_15370 ENOG4105CKK Glycosyl transferase, family 2 EJ379_15400 ENOG4105C8Y Acetylornithine aminotransferase EJ379_15445 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EJ379_15455 ENOG4108IBT Inherit from COG: transposase EJ379_15475 ENOG4108TVJ Nitroreductase EJ379_15480 ENOG4105FS7 Transcriptional regulator EJ379_15500 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EJ379_15515 ENOG4105CMR udp-glucose 4-epimerase EJ379_15525 ENOG4108DMH HTH_ARAC EJ379_15530 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EJ379_15535 ENOG4108XET gCN5-related N-acetyltransferase EJ379_15610 ENOG410635A Membrane EJ379_15620 ENOG4108IQI permease EJ379_15630 ENOG4105F1N DNA alkylation repair EJ379_15670 ENOG4107RF6 penicillin-binding protein EJ379_15675 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EJ379_15680 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) EJ379_15695 ENOG4105E7W lamb ycsf family protein EJ379_15705 ENOG4105P4J Allophanate hydrolase, subunit 1 EJ379_15710 ENOG4107258 Transcriptional regulator EJ379_15720 ENOG4106N3A copper homeostasis protein cutc EJ379_15725 ENOG4108ZHR arsR family transcriptional regulator EJ379_15735 ENOG4105FDT acyl-CoA dehydrogenase EJ379_15750 ENOG4105DWD nucleoside recognition domain protein EJ379_15795 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EJ379_15820 ENOG4105E2A Dehydrogenase EJ379_15825 ENOG4108IJ0 Aspartate ammonia-lyase EJ379_15830 ENOG4105HDK L-asparaginase EJ379_15835 ENOG4108IMY Transcriptional regulator EJ379_15860 ENOG4108B31 Spore germination protein EJ379_15870 ENOG4105BZU Histidine kinase EJ379_15895 ENOG41075H3 AraC family transcriptional regulator EJ379_15910 ENOG4105YWU small acid-soluble spore protein EJ379_15915 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EJ379_15920 ENOG4105CUB amino acid EJ379_15925 ENOG4105II7 pyrroline-5-carboxylate reductase EJ379_15930 ENOG4108NHD germination protein EJ379_15935 ENOG4108Q8B Spore germination protein EJ379_15970 ENOG4106A3M Cytochrome p-450 EJ379_15990 ENOG4105CGH 5'-nucleotidase EJ379_16000 ENOG4105CHJ isochorismatase hydrolase EJ379_16025 ENOG41090MY MarR family Transcriptional regulator EJ379_16050 ENOG4105F6J Alpha beta hydrolase fold EJ379_16065 ENOG4108606 TspO/MBR family EJ379_16070 ENOG4105CVP deoxyribo-dipyrimidine photolyase EJ379_16095 ENOG4108TWJ NADH dehydrogenase subunit 5 EJ379_16100 ENOG4105GPN Uncharacterized conserved protein (DUF2294) EJ379_16120 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EJ379_16125 ENOG4105ECQ AraC Family Transcriptional Regulator EJ379_16130 ENOG4105Z7P Acetyltransferase (GNAT) family EJ379_16135 ENOG4108SY2 LMWPc EJ379_16140 ENOG4105D6J arsenicaL-resistance protein EJ379_16145 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase EJ379_16150 ENOG41085FC arsR family transcriptional regulator EJ379_16160 ENOG4105NAE bifunctional deaminase-reductase domain protein EJ379_16165 ENOG4107P5I polyketide synthase EJ379_16170 ENOG4108IG5 Transcriptional regulator EJ379_16185 ENOG4105EQ0 Major Facilitator superfamily EJ379_16190 ENOG4108JGH Tetr family transcriptional regulator EJ379_16200 ENOG4105XRQ Xanthine dehydrogenase accessory factor EJ379_16215 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding EJ379_16245 ENOG4105CHR reductase EJ379_16250 ENOG4108YXU transcriptional regulator AsnC family EJ379_16330 ENOG4105C44 Serine transporter EJ379_16340 ENOG4105DWP Membrane EJ379_16390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_16395 ENOG41062D9 Histidine kinase EJ379_16440 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EJ379_16445 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJ379_16465 ENOG4105K6H D-cysteine desulfhydrase EJ379_16480 ENOG4105JQZ Methyltransferase EJ379_16500 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) EJ379_16520 ENOG4105BZU Histidine kinase EJ379_16530 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EJ379_16540 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EJ379_16595 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) EJ379_16605 ENOG4105DVH amino acid EJ379_16625 ENOG4108JQ1 Dehydrogenase EJ379_16630 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EJ379_16645 ENOG41082W1 Cupin 2, conserved barrel domain protein EJ379_16655 ENOG410874W AraC family transcriptional regulator EJ379_16675 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EJ379_16925 ENOG4108VXD carboxy-peptidase EJ379_16930 ENOG4105PNM synthesis protein EJ379_16940 ENOG4108ISG Major Facilitator EJ379_16955 ENOG4107MII Sugar-specific transcriptional regulator TrmB EJ379_16960 ENOG4105CZM Major Facilitator EJ379_16970 ENOG4108Z66 YbaK ebsC protein EJ379_16975 ENOG4105CUT histidyl-tRNA synthetase EJ379_16990 ENOG4105KVH Transcriptional regulator EJ379_16995 ENOG4108RCM Nitroreductase EJ379_17025 ENOG4108PSK reductase EJ379_17100 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EJ379_17130 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) EJ379_17140 ENOG4105EV4 Multidrug resistance protein mdtH EJ379_17170 ENOG4105C37 (CBS) domain EJ379_17185 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase EJ379_17190 ENOG4105FAW cDP-glucose 4,6-dehydratase EJ379_17225 ENOG4105DDN Pentapeptide repeat-containing protein EJ379_17230 ENOG4105XDF Protein of unknown function (DUF1272) EJ379_17235 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) EJ379_17240 ENOG4105CMG Carbohydrate kinase EJ379_17245 ENOG4105C6Z Gluconate EJ379_17260 ENOG4105CV1 Transketolase (EC 2.2.1.1) EJ379_17265 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EJ379_17280 ENOG4105CIS alcohol dehydrogenase EJ379_17285 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone EJ379_17305 ENOG4105EWI Short-chain dehydrogenase reductase Sdr EJ379_17320 ENOG4105C8Q Methyl-accepting chemotaxis EJ379_17325 ENOG4108UX3 '-nucleotidase EJ379_17330 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EJ379_17335 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EJ379_17340 ENOG4105KVH Transcriptional regulator EJ379_17355 ENOG4105CV8 reductase EJ379_17360 ENOG4105F27 Major Facilitator EJ379_17370 ENOG41090KN UPF0303 protein EJ379_17385 ENOG4105C44 Serine transporter EJ379_17415 ENOG4105KVH Transcriptional regulator EJ379_17420 ENOG4108TZY GntR Family Transcriptional Regulator EJ379_17425 ENOG4105D9R oxidoreductase EJ379_17430 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EJ379_17435 ENOG4105KVH Transcriptional regulator EJ379_17440 ENOG4105KVH Transcriptional regulator EJ379_17485 ENOG4105JAB phenazine biosynthesis protein, phzf family EJ379_17495 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EJ379_17500 ENOG4105KVH Transcriptional regulator EJ379_17510 ENOG4108ZJ4 polysaccharide deacetylase EJ379_17530 ENOG410829K Lysine exporter protein (Lyse ygga) EJ379_17585 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) EJ379_17595 ENOG4107YXZ hydrolase, family 25 EJ379_17625 ENOG4105H3G oxidoreductase EJ379_17695 ENOG4108TN2 lmbE family EJ379_17705 ENOG4107R3E Citrate transporter EJ379_17715 ENOG4105WCN acetyltransferase EJ379_17720 ENOG4108MES Periplasmic binding protein EJ379_17725 ENOG4105EHG Permease protein EJ379_17730 ENOG4105DQ5 transport system permease protein EJ379_17735 ENOG4105NX3 Membrane EJ379_17755 ENOG41068WN EJ379_17760 ENOG4107CUJ Protein of unknown function (DUF2690) EJ379_17770 ENOG4107V2S Transcriptional regulator EJ379_17800 ENOG4105E5K Alpha-amylase EJ379_17805 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase EJ379_17810 ENOG4105DPN Oligoendopeptidase f EJ379_17850 ENOG4108A04 Beta-lactamase EJ379_17875 ENOG4107VXM glycerophosphoryl diester phosphodiesterase EJ379_17885 ENOG41082BM Transcriptional regulator, arsr family EJ379_17890 ENOG4105CIS alcohol dehydrogenase EJ379_17895 ENOG4105CNG UPF0061 protein EJ379_17915 ENOG4105CQB FAD linked oxidase domain protein EJ379_17940 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EJ379_17950 ENOG4107TPS domain protein EJ379_17955 ENOG4105CEP NADH dehydrogenase EJ379_17965 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase EJ379_17975 ENOG4108IAJ Nad-dependent epimerase dehydratase EJ379_17980 ENOG4105FAW cDP-glucose 4,6-dehydratase EJ379_18015 ENOG41067SE Tetr family transcriptional regulator EJ379_18020 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity EJ379_18030 ENOG4107DUR UPF0457 protein EJ379_18050 ENOG4105BZU Histidine kinase EJ379_18060 ENOG4105KT7 mgtC SapB transporter EJ379_18070 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EJ379_18075 ENOG41073R8 VanW family EJ379_18085 ENOG4108R1P EJ379_18100 ENOG4105VEQ Cold shock protein EJ379_18120 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EJ379_18140 ENOG410904N short-chain dehydrogenase reductase EJ379_18150 ENOG4106IQC argininosuccinate lyase EJ379_18165 ENOG4108IA2 Sodium pantothenate symporter EJ379_18175 ENOG4105C26 Dehydrogenase EJ379_18180 ENOG4105CHR reductase EJ379_18190 ENOG4105EWU Squalene--hopene cyclase EJ379_18200 ENOG4105FR1 rard protein EJ379_18205 ENOG410696E Membrane EJ379_18220 ENOG4105D1F ATP-binding protein EJ379_18230 ENOG4108ZAF Molybdopterin EJ379_18235 ENOG4105CVM Molybdenum cofactor synthesis domain protein EJ379_18240 ENOG4105D06 uba thif-type nad fad binding protein EJ379_18245 ENOG4105TMB Formate nitrite transporter EJ379_18255 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EJ379_18260 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) EJ379_18270 ENOG4108JB9 formate dehydrogenase EJ379_18275 ENOG4105E1K spore germination protein EJ379_18290 ENOG4105CUB amino acid EJ379_18345 ENOG4108KGH TRANSCRIPTIONal EJ379_18355 ENOG4105EMN RNA polymerase sigma factor EJ379_18365 ENOG4105CIG ABC transporter EJ379_18385 ENOG4105D9R oxidoreductase EJ379_18395 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJ379_18400 ENOG4105K4P CoA-binding domain protein EJ379_18405 ENOG4105C0H protease EJ379_18410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_18420 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase EJ379_18430 ENOG4105W8X HesB YadR YfhF-family protein EJ379_18460 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) EJ379_18465 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EJ379_18480 ENOG4105BZ1 (ABC) transporter EJ379_18485 ENOG4108I0Z Aconitate hydratase EJ379_18515 ENOG4105E5W Transporter EJ379_18525 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EJ379_18545 ENOG4107F3J Amp-dependent synthetase and ligase EJ379_18550 ENOG4107ZYJ bioY protein EJ379_18555 ENOG4105CEY Amp-dependent synthetase and ligase EJ379_18600 ENOG4107AYK membrAne EJ379_18615 ENOG4105BZU Histidine kinase EJ379_18620 ENOG4105FBA Phospholipase Carboxylesterase EJ379_18625 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase EJ379_18630 ENOG4105CK7 Sodium proline symporter EJ379_18640 ENOG4105CBC glutamate synthase EJ379_18645 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EJ379_18650 ENOG4108VJ1 Transcriptional regulator (CarD family EJ379_18655 ENOG4108903 Formimidoylglutamase EJ379_18660 ENOG4105CI2 imidazolone-5-propionate hydrolase EJ379_18665 ENOG4105CGP Urocanate hydratase EJ379_18710 ENOG4107QIV Cytochrome c biogenesis protein EJ379_18735 ENOG4105CJ1 ABC, transporter EJ379_18750 ENOG4107RSM transcriptional regulator EJ379_18760 ENOG41067MG lrgb family EJ379_18800 ENOG4105BZ1 (ABC) transporter EJ379_18805 ENOG4105BZ1 (ABC) transporter EJ379_18840 ENOG4108HW3 (ABC) transporter EJ379_18845 ENOG4105CGH 5'-nucleotidase EJ379_18855 ENOG4108SVB resolvase EJ379_18875 ENOG4105K7K Transcriptional regulator EJ379_18880 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EJ379_18900 ENOG4105E4C Lytic transglycosylase catalytic EJ379_18905 ENOG41065S2 pneumococcal vaccine antigen EJ379_18940 ENOG4105C5F glutamine synthetase EJ379_18945 ENOG4105KV4 Transcriptional regulator EJ379_18950 ENOG4105CXI aluminum resistance protein EJ379_18955 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EJ379_18960 ENOG4105EN6 Membrane EJ379_18965 ENOG4106F1P AAA ATPase, central domain protein EJ379_18995 ENOG41069ER domain protein EJ379_19000 ENOG4105DM4 PTS System EJ379_19005 ENOG4105DE4 1-phosphofructokinase EJ379_19010 ENOG4105E98 transcriptional regulator DeoR family EJ379_19015 ENOG4107QW4 alcohol dehydrogenase EJ379_19020 ENOG4108SJC Membrane EJ379_19030 ENOG4105C85 amino acid EJ379_19050 ENOG4105TMB Formate nitrite transporter EJ379_19055 ENOG4105K70 DNA-binding protein EJ379_19065 ENOG4105C59 p-type ATPase EJ379_19070 ENOG410681U heavy metal transport detoxification protein EJ379_19075 ENOG4105VPX protein, conserved in bacteria EJ379_19085 ENOG4105NIV Esterase EJ379_19090 ENOG4105E0A ABC, transporter EJ379_19110 ENOG4105CGK Exodeoxyribonuclease III EJ379_19120 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EJ379_19125 ENOG4105D03 DNA-3-methyladenine glycosylase II EJ379_19130 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EJ379_19150 ENOG4105BZU Histidine kinase EJ379_19190 ENOG41067MG lrgb family EJ379_19210 ENOG4108S3Y transcriptional regulator EJ379_19215 ENOG4105CS2 ec 3.2.1.21 EJ379_19230 ENOG4105F0V Cell wall hydrolase EJ379_19245 ENOG4105E0M Sulfatase EJ379_19250 ENOG410890F Dynamin family EJ379_19280 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EJ379_19285 ENOG4105DQU oxidoreductase, subunit beta EJ379_19290 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein EJ379_19295 ENOG4108IGT Dipeptidase EJ379_19300 ENOG4105MCT stage V sporulation protein S EJ379_19305 ENOG4105D48 metallophosphoesterase EJ379_19320 ENOG4105CEV competence damage-inducible protein EJ379_19325 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EJ379_19340 ENOG4105XZV Protein of unknown function (DUF3243) EJ379_19345 ENOG4108RKS Short-chain dehydrogenase reductase Sdr EJ379_19365 ENOG4105UIB (ABC) transporter EJ379_19370 ENOG4108JQ9 ABC transporter EJ379_19375 ENOG4105DIH basic membrane EJ379_19380 ENOG4105FDP GntR family transcriptional regulator EJ379_19390 ENOG4105CNU cell division protein FtsK EJ379_19400 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit EJ379_19410 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EJ379_19420 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EJ379_19425 ENOG4108S0H Dipicolinic acid synthetase, b subunit EJ379_19430 ENOG4105E35 Dipicolinate synthase subunit A EJ379_19440 ENOG4105C1V Peptidase, M16 EJ379_19460 ENOG4105DTN riboflavin biosynthesis protein ribF EJ379_19475 ENOG4105W7A Protein of unknown function (DUF503) EJ379_19485 ENOG4105VHM ribosomal protein EJ379_19490 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination EJ379_19495 ENOG4105CHV Transcription elongation factor NusA EJ379_19505 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) EJ379_19515 ENOG4105DZP Membrane-associated zinc metalloprotease EJ379_19520 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EJ379_19525 ENOG4105KNE Phosphatidate cytidylyltransferase EJ379_19530 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EJ379_19540 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) EJ379_19570 ENOG4108HE4 integrase family EJ379_19575 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) EJ379_19580 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EJ379_19585 ENOG4105C79 DNA protecting protein DprA EJ379_19590 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EJ379_19600 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EJ379_19605 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) EJ379_19630 ENOG4105VB6 UPF0109 protein EJ379_19650 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EJ379_19655 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) EJ379_19670 ENOG4105CHR reductase EJ379_19675 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EJ379_19680 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EJ379_19690 ENOG4105CB5 ATP-dependent DNA helicase recG EJ379_19695 ENOG4105DP4 dak2 domain fusion protein ylov EJ379_19700 ENOG4108ZAA Alkaline-shock protein EJ379_19715 ENOG4105FJ0 thiamine EJ379_19720 ENOG4105DJV ribulose-phosphate 3-epimerase EJ379_19725 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EJ379_19730 ENOG4105D9P serine threonine protein kinase EJ379_19735 ENOG4108ZF3 Phosphatase EJ379_19740 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EJ379_19745 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EJ379_19760 ENOG4105C25 Primosomal protein n' EJ379_19765 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EJ379_19785 ENOG4105DSJ YicC domain protein EJ379_19805 ENOG4105DC7 peptidase M24 EJ379_19840 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EJ379_19855 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) EJ379_19860 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EJ379_19865 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EJ379_19870 ENOG4105CD3 dihydroorotase EJ379_19890 ENOG4105C34 Pseudouridine synthase EJ379_19915 ENOG4105DBK s4 domain protein EJ379_19920 ENOG41067XK integral membrane protein EJ379_19930 ENOG4105DFA alanine racemase domain protein EJ379_19935 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EJ379_19940 ENOG4105WR5 sporulation protein, YlmC YmxH family EJ379_19950 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ379_19960 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EJ379_19965 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EJ379_19975 ENOG4105D4A Cell wall formation (By similarity) EJ379_19980 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EJ379_19985 ENOG4105CNI cell division protein FtsW EJ379_19990 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EJ379_20000 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EJ379_20005 ENOG4105CJN penicillin-binding protein EJ379_20010 ENOG4105CJN penicillin-binding protein EJ379_20025 ENOG41074B2 UPF0747 protein EJ379_20050 ENOG4105KNH Nucleic acid-binding protein EJ379_20060 ENOG41063PX domain protein EJ379_20065 ENOG4105D78 K07001 NTE family protein EJ379_20070 ENOG4105H20 Sporulation integral membrane protein YlbJ EJ379_20080 ENOG4106H78 methyltransferase EJ379_20100 ENOG4107TB6 phosphoglycerate mutase EJ379_20115 ENOG4106UY4 Inherit from COG: Scp-like extracellular EJ379_20160 ENOG4107VFP cytochrome oxidase assembly EJ379_20165 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) EJ379_20175 ENOG4105CNI cell division protein FtsW EJ379_20190 ENOG4108IAB Phoh family EJ379_20210 ENOG4105QA2 EJ379_20215 ENOG4105CI3 gtp-binding protein typa EJ379_20225 ENOG4105ECY inositol monophosphatase EJ379_20245 ENOG4105CXN decarboxylase EJ379_20295 ENOG4105CPP Dehydrogenase, E1 component EJ379_20310 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EJ379_20315 ENOG4108X4Q Hydrolase EJ379_20330 ENOG4105CN5 Metallo-Beta-Lactamase EJ379_20335 ENOG4107ZYR domain protein EJ379_20345 ENOG4105CH2 amidohydrolase EJ379_20370 ENOG4108XRC Protein of unknown function (DUF458) EJ379_20375 ENOG4107IN1 Protein of unknown function (DUF1797) EJ379_20390 ENOG4105EPM Diguanylate phosphodiesterase EJ379_20395 ENOG4105K6S Short-chain dehydrogenase reductase Sdr EJ379_20410 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) EJ379_20420 ENOG4105UIN EJ379_20455 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EJ379_20475 ENOG4108HGU Histidine kinase EJ379_20485 ENOG4105CHM Aminotransferase EJ379_20490 ENOG4105FKQ transcriptional regulator EJ379_20495 ENOG4105EG2 ABC transporter, permease EJ379_20505 ENOG4107FKK extracellular solute-binding protein family 1 EJ379_20515 ENOG4105CG3 alpha amylase, catalytic region EJ379_20560 ENOG4105CHU acetyl-coa acetyltransferase EJ379_20595 ENOG4105K7K Transcriptional regulator EJ379_20600 ENOG4105DTD Dehydrogenase EJ379_20615 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) EJ379_20620 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EJ379_20630 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate EJ379_20645 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) EJ379_20660 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EJ379_20670 ENOG4105BZU Histidine kinase EJ379_20690 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EJ379_20705 ENOG4105CID antiterminator EJ379_20725 ENOG4105CE4 GlcNAc 6-P deacetylase EJ379_20765 ENOG4107ZE5 PPIases accelerate the folding of proteins EJ379_20770 ENOG4105PTM secreted protein EJ379_20775 ENOG4105J7I hydrolase EJ379_20785 ENOG4105G6R Stage v sporulation protein ae EJ379_20795 ENOG4105CZ3 stage V sporulation protein ad EJ379_20800 ENOG41090VF Stage v sporulation protein ac EJ379_20820 ENOG4105C8J )-transporter EJ379_20825 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ379_20835 ENOG41082AN stage II sporulation protein EJ379_20840 ENOG4105DZ1 carboxypeptidase EJ379_20850 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EJ379_20855 ENOG4105DVE abc transporter atp-binding protein EJ379_20890 ENOG4105D7N magnesium and cobalt transport protein CorA EJ379_20915 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EJ379_20925 ENOG4105I3K Ferric uptake regulator, Fur family EJ379_20930 ENOG4105MZ9 stage II sporulation protein m EJ379_20950 ENOG4105CPC Aldo Keto reductase EJ379_20960 ENOG4105RHY Pfam:UPF0157 EJ379_20980 ENOG4107SKW Inherit from COG: Alpha beta hydrolase EJ379_20990 ENOG4105ETE Transcriptional regulator (LacI family EJ379_20995 ENOG4108YM7 Gcn5-related n-acetyltransferase EJ379_21015 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EJ379_21020 ENOG4108R6K riboflavin synthase, subunit alpha EJ379_21025 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EJ379_21045 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EJ379_21050 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EJ379_21060 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EJ379_21065 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EJ379_21080 ENOG4105DFD Na H antiporter EJ379_21085 ENOG4105CGH 5'-nucleotidase EJ379_21110 ENOG4105DBV ornithine carbamoyltransferase EJ379_21125 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EJ379_21140 ENOG4108IXY short-chain dehydrogenase reductase EJ379_21145 ENOG41069FQ Metallo-beta-lactamase superfamily EJ379_21150 ENOG4105II7 pyrroline-5-carboxylate reductase EJ379_21155 ENOG4105EJQ L-serine dehydratase EJ379_21170 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EJ379_21185 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EJ379_21200 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EJ379_21205 ENOG4105D9U N-acetyltransferase EJ379_21215 ENOG4108VZI ErfK ybiS ycfS ynhG family protein EJ379_21220 ENOG4108QEG Membrane EJ379_21225 ENOG4105CDA abc transporter atp-binding protein EJ379_21230 ENOG4105E5Q amino acid AbC transporter EJ379_21235 ENOG4108HW3 (ABC) transporter EJ379_21245 ENOG4105G7B Protein of unknown function (DUF2992) EJ379_21250 ENOG4105E09 nadh pyrophosphatase EJ379_21255 ENOG4108QY0 Membrane EJ379_21265 ENOG4105C7S Dehydrogenase EJ379_21270 ENOG4105CPP Dehydrogenase, E1 component EJ379_21285 ENOG4105CKM Branched-chain carboxylic acid kinase EJ379_21290 ENOG4107RDP Dehydrogenase EJ379_21305 ENOG4108JUB Transcriptional regulator EJ379_21315 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EJ379_21330 ENOG4107QQR Sporulation EJ379_21340 ENOG4105S1Z Stage IV sporulation protein B EJ379_21345 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EJ379_21350 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) EJ379_21355 ENOG4105DX0 Hemolysin A EJ379_21365 ENOG4105CTB Polyprenyl synthetase EJ379_21380 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EJ379_21390 ENOG4108ZSR alkaline shock protein EJ379_21395 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EJ379_21420 ENOG410644B Stage III sporulation protein af EJ379_21430 ENOG4105KQ4 Stage iii sporulation protein ad EJ379_21435 ENOG4108CQH stage III sporulation protein AC EJ379_21440 ENOG4105KR5 Stage iii sporulation protein EJ379_21445 ENOG4105CD2 stage iii sporulation protein aa EJ379_21470 ENOG4105DC7 peptidase M24 EJ379_21475 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EJ379_21485 ENOG4105CBJ Metal-dependent enzyme EJ379_21495 ENOG4107YBY Hydrolase EJ379_21525 ENOG41082GG biotin lipoate A B protein ligase EJ379_21530 ENOG4105WZW rhodanese family EJ379_21555 ENOG41080TC multidrug resistance protein EJ379_21590 ENOG4105CJ1 ABC, transporter EJ379_21595 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EJ379_21610 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EJ379_21630 ENOG4105C0D helicase EJ379_21715 ENOG4107R6U sodium dicarboxylate symporter EJ379_21750 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EJ379_21755 ENOG4105C3R Methionine synthase EJ379_21765 ENOG4105C28 cystathionine EJ379_21770 ENOG4105C28 cystathionine EJ379_21790 ENOG4105C5X domain protein EJ379_21800 ENOG4105DKQ ROK family EJ379_21810 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EJ379_21830 ENOG4108UTW Plays a role in the regulation of phosphate uptake EJ379_21835 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EJ379_21840 ENOG4105C8U phosphate abc transporter EJ379_21845 ENOG4105C8U phosphate abc transporter EJ379_21850 ENOG4105EXS phosphate abc transporter EJ379_21855 ENOG4107RF6 penicillin-binding protein EJ379_21865 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EJ379_21890 ENOG4105N80 Ferric uptake regulator, Fur family EJ379_21900 ENOG4105FDK ABC transporter EJ379_21905 ENOG4108JYZ YitT family EJ379_21910 ENOG41069ZM Protein of unknown function (DUF2624) EJ379_21935 ENOG4105EGD dinuclear metal center protein, YbgI family EJ379_21950 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ379_21955 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EJ379_21960 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) EJ379_21980 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EJ379_21985 ENOG4105KG3 cytidine deaminase EJ379_21990 ENOG4107YR5 Diacylglycerol kinase EJ379_21995 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EJ379_22000 ENOG4105CTJ Metal Dependent Phosphohydrolase EJ379_22005 ENOG4105C9A Phoh family EJ379_22015 ENOG41068P3 sporulation protein YqfC EJ379_22025 ENOG4105KTH gatB Yqey EJ379_22035 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EJ379_22040 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EJ379_22070 ENOG4105CSA Coproporphyrinogen iii oxidase EJ379_22075 ENOG4105KVH Transcriptional regulator EJ379_22100 ENOG4105TQK DNA polymerase iii, delta' subunit EJ379_22110 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EJ379_22115 ENOG4108UK2 deaminase EJ379_22120 ENOG4105KQC Competence protein EJ379_22130 ENOG4105DXX methyltransferase EJ379_22140 ENOG4108WF2 Metal Dependent Phosphohydrolase EJ379_22150 ENOG410812S Rna-binding protein EJ379_22160 ENOG4105CQW ribosome biogenesis GTPase YqeH EJ379_22165 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase EJ379_22180 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ379_22200 ENOG4108TVJ Nitroreductase EJ379_22215 ENOG4105G6Z alkaline phosphatase EJ379_22220 ENOG4105KEG ribosomal-protein-alanine acetyltransferase EJ379_22225 ENOG4108MUZ hydrolase EJ379_22265 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin EJ379_22270 ENOG4105MIR Phenylalanine 4-monooxygenase EJ379_22280 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EJ379_22320 ENOG4105S6R Iron-hydroxamate transporter permease subunit EJ379_22325 ENOG4108HUF Transporter EJ379_22340 ENOG4105C0A alcohol dehydrogenase EJ379_22345 ENOG4105C28 cystathionine EJ379_22375 ENOG4107XRG penicillin-binding protein EJ379_22385 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EJ379_22395 ENOG4105CFP Peptidase U32 EJ379_22400 ENOG4105XYU peptidase (U32 family) EJ379_22410 ENOG4105HHA aminodeoxychorismate lyase EJ379_22430 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EJ379_22440 ENOG4105C02 permease EJ379_22455 ENOG41060CR EJ379_22460 ENOG4105C7H Helicase, RecD TraA family EJ379_22470 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EJ379_22475 ENOG4105C3J Cysteine desulfurase EJ379_22485 ENOG4105D1H recombination factor protein RarA EJ379_22490 ENOG4108VCI transcription factor, rsfa family EJ379_22500 ENOG4105CUZ uba thif-type nad fad binding protein EJ379_22510 ENOG4105CUT histidyl-tRNA synthetase EJ379_22515 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EJ379_22520 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EJ379_22530 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EJ379_22535 ENOG41076HS cation diffusion facilitator family transporter EJ379_22540 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EJ379_22550 ENOG4105CKP Polysaccharide Biosynthesis Protein EJ379_22555 ENOG4108QG2 Membrane EJ379_22565 ENOG4105VIE preprotein translocase, subunit YajC EJ379_22575 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EJ379_22580 ENOG41061AI Protein of unknown function (DUF2905) EJ379_22595 ENOG4108HUF Transporter EJ379_22620 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EJ379_22625 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EJ379_22630 ENOG4108IYU L-aspartate oxidase EJ379_22645 ENOG4108RPX mosc domain containing protein EJ379_22650 ENOG4105CQC Prephenate dehydratase EJ379_22665 ENOG4105C19 ABC transporter EJ379_22670 ENOG4105EWM Histidine kinase EJ379_22680 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EJ379_22700 ENOG4105C03 ribonuclease EJ379_22715 ENOG4107QMS site-determining protein EJ379_22735 ENOG4105DFF Rod shape-determining protein mreb EJ379_22780 ENOG4105DZR Type I site-specific deoxyribonuclease EJ379_22810 ENOG4108Z03 MAF-like protein EJ379_22820 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EJ379_22825 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EJ379_22835 ENOG41068KH stage VI sporulation protein D EJ379_22845 ENOG4105D52 delta-aminolevulinic acid dehydratase EJ379_22870 ENOG4105K56 Transcriptional regulator EJ379_22890 ENOG4108IUQ atp-dependent protease EJ379_22915 ENOG4108QCI YvbH-like oligomerisation region EJ379_22930 ENOG4105C4R Atp-dependent dna helicase EJ379_22955 ENOG4105M59 Phosphodiesterase, mj0936 family EJ379_22960 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EJ379_22970 ENOG4108XJQ germination protein EJ379_22980 ENOG4108PCX Major Facilitator EJ379_22990 ENOG4105KBX Transcriptional regulator, TetR family EJ379_23000 ENOG4105PFC Transcriptional regulator EJ379_23010 ENOG4105DZC cytosine deaminase EJ379_23015 ENOG41067S9 phage shock protein C, PspC EJ379_23020 ENOG4108JCI Transcriptional regulator EJ379_23030 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EJ379_23035 ENOG4108Z40 Transcriptional regulator EJ379_23040 ENOG4105RHA ABC transporter, permease EJ379_23045 ENOG4108IUX (ABC) transporter EJ379_23050 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family EJ379_23055 ENOG4105ER2 Ompa motb domain protein EJ379_23060 ENOG4105E14 MotA TolQ exbB proton channel EJ379_23065 ENOG4108VXD carboxy-peptidase EJ379_23075 ENOG4105E33 succinate dehydrogenase EJ379_23085 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit EJ379_23095 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EJ379_23100 ENOG4105K63 Thioredoxin EJ379_23105 ENOG4105C10 Electron transfer flavoprotein EJ379_23110 ENOG4105BZJ Electron transfer flavoprotein EJ379_23115 ENOG41060WC Enoyl-CoA hydratase EJ379_23120 ENOG4107Z3H Transcriptional regulator, TetR family EJ379_23125 ENOG4105CEY Amp-dependent synthetase and ligase EJ379_23135 ENOG4105J76 Periplasmic binding protein EJ379_23140 ENOG4105S6R Iron-hydroxamate transporter permease subunit EJ379_23185 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EJ379_23195 ENOG4105DR4 Methyltransferase EJ379_23205 ENOG4105KFN sortase, SrtB family EJ379_23210 ENOG4105E0A ABC, transporter EJ379_23225 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) EJ379_23235 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) EJ379_23245 ENOG4105FE9 pseudouridine synthase EJ379_23255 ENOG4105DCG PHP domain protein EJ379_23270 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EJ379_23290 ENOG4105C5S asparaginyl-tRNA synthetase EJ379_23295 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EJ379_23305 ENOG4108RWN rrna methyltransferase EJ379_23335 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJ379_23340 ENOG4105CW7 secretion protein, HlyD family EJ379_23345 ENOG4108JGH Tetr family transcriptional regulator EJ379_23350 ENOG4105CN9 Peptidase m42 family protein EJ379_23370 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EJ379_23375 ENOG4105C22 threonyL-tRNA synthetase EJ379_23380 ENOG4108TDW sporulation protein YtxC EJ379_23410 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EJ379_23415 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EJ379_23425 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EJ379_23430 ENOG4105C2M dna polymerase I EJ379_23435 ENOG4105BZU Histidine kinase EJ379_23440 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EJ379_23455 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EJ379_23460 ENOG4108HMX isocitrate dehydrogenase (NADP) EJ379_23465 ENOG4105BZN citrate synthase EJ379_23480 ENOG4108REF Sporulation integral membrane protein ytvi EJ379_23485 ENOG4105FS0 cytoplasmic membrane protein EJ379_23510 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family EJ379_23515 ENOG4105C6K Malic enzyme EJ379_23520 ENOG4105C0B DNA polymerase III (alpha subunit) EJ379_23525 ENOG4105VV2 EJ379_23535 ENOG4105SFS phosphoesterase RecJ domain protein EJ379_23555 ENOG4105E8R UPF0173 metal-dependent hydrolase EJ379_23560 ENOG4105DC7 peptidase M24 EJ379_23595 ENOG4105Z7P Acetyltransferase (GNAT) family EJ379_23600 ENOG41082W1 Cupin 2, conserved barrel domain protein EJ379_23620 ENOG4107YZX Universal stress protein EJ379_23640 ENOG4105CH7 arginosuccinase EJ379_23660 ENOG4108JYZ YitT family EJ379_23680 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EJ379_23690 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) EJ379_23695 ENOG4105KBJ sporulation protein ytfj EJ379_23710 ENOG4105EFZ amidohydrolase EJ379_23720 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJ379_23730 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) EJ379_23745 ENOG4105RQF LysR family Transcriptional regulator EJ379_23755 ENOG4105U5Y Transcriptional regulator EJ379_23765 ENOG4105C28 cystathionine EJ379_23785 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EJ379_23790 ENOG4108UW5 maltose o-acetyltransferase EJ379_23800 ENOG4105F1V Acetoin utilization protein EJ379_23805 ENOG4105W87 Cbs domain EJ379_23810 ENOG4105DGU Histone deacetylase EJ379_23825 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EJ379_23835 ENOG4107SNB ankyrin repeat protein YahD EJ379_23840 ENOG4105EP9 oxidoreductase EJ379_23860 ENOG4105ETE Transcriptional regulator (LacI family EJ379_23865 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EJ379_23885 ENOG4105C88 aminopeptidase EJ379_23930 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EJ379_23940 ENOG4108VDD TRNA binding domain protein EJ379_23970 ENOG4105C8F Beta-lactamase domain protein EJ379_23985 ENOG4108V15 phosphotransferase enzyme family EJ379_23990 ENOG4108IUM Glycogen debranching enzyme EJ379_24000 ENOG4107QSE Dipeptidase EJ379_24005 ENOG4105YW5 deoR family transcriptional regulator EJ379_24020 ENOG4105CBX hi0933 family EJ379_24055 ENOG4108VJ1 Transcriptional regulator (CarD family EJ379_24060 ENOG4107EXU Short-chain dehydrogenase reductase Sdr EJ379_24065 ENOG4105CSC Glucose uptake protein EJ379_24080 ENOG4108ZAF Molybdopterin EJ379_24085 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein EJ379_24090 ENOG4105CVM Molybdenum cofactor synthesis domain protein EJ379_24100 ENOG4105D06 uba thif-type nad fad binding protein EJ379_24105 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EJ379_24130 ENOG41085GJ domain protein EJ379_24140 ENOG4105DWV Homoserine O-trans-acetylase EJ379_24150 ENOG4108B31 Spore germination protein EJ379_24175 ENOG4105C8T Leucyl-tRNA synthetase EJ379_24180 ENOG410605W Major Facilitator EJ379_24185 ENOG4107S91 Sodium hydrogen exchanger EJ379_24190 ENOG4105NCW Trka-c domain protein EJ379_24210 ENOG4105C19 ABC transporter EJ379_24230 ENOG4105N5T Radical SAM Protein EJ379_24245 ENOG4105CIG ABC transporter EJ379_24275 ENOG4105E8V Alpha Beta Hydrolase Fold protein EJ379_24280 ENOG4108Z0R Transferase EJ379_24285 ENOG4105YVM Phosphoesterase, PA-phosphatase related EJ379_24290 ENOG4105BZF Glycosyl transferase (Group 1 EJ379_24300 ENOG4105EPU Molybdenum cofactor synthesis domain protein EJ379_24310 ENOG4108MK9 spermidine N(1)-acetyltransferase EJ379_24360 ENOG4105BZU Histidine kinase EJ379_24365 ENOG4105BZU Histidine kinase EJ379_24370 ENOG4105CH6 catalase EJ379_24380 ENOG4107S9D Alpha beta hydrolase EJ379_24385 ENOG4107T7U Sulfatase EJ379_24400 ENOG4105D2X ABC transporter substrate-binding protein EJ379_24410 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component EJ379_24475 ENOG4108V2W Carbonate dehydratase EJ379_24480 ENOG4105C4M (Ubiquinol oxidase) subunit I EJ379_24485 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EJ379_24525 ENOG41087YS Phage shock protein A EJ379_24565 ENOG4105BZU Histidine kinase EJ379_24570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_24595 ENOG4108UGV hypoxanthine phosphoribosyltransferase EJ379_24600 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) EJ379_24645 ENOG4105C19 ABC transporter EJ379_24660 ENOG4107ZTW SNARE associated Golgi EJ379_24665 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EJ379_24675 ENOG4105C19 ABC transporter EJ379_24680 ENOG41086D8 Transcriptional regulator EJ379_24690 ENOG41082BM Transcriptional regulator, arsr family EJ379_24730 ENOG4105C6Z Gluconate EJ379_24755 ENOG41069H0 dihydroorotase EC 3.5.2.3 EJ379_24780 ENOG4105DTQ mandelate racemase muconate lactonizing EJ379_24785 ENOG4105CEY Amp-dependent synthetase and ligase EJ379_24790 ENOG4108IPT Naphthoate synthase EJ379_24795 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) EJ379_24800 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) EJ379_24805 ENOG4105E4F Isochorismate synthase EJ379_24810 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EJ379_24820 ENOG4105VEQ Cold shock protein EJ379_24840 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) EJ379_24850 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) EJ379_24855 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) EJ379_24865 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin EJ379_24970 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EJ379_25005 ENOG4105KT7 mgtC SapB transporter EJ379_25010 ENOG4107PBV potassium channel EJ379_25030 ENOG4105WG9 Conserved Protein EJ379_25040 ENOG4105CHM Aminotransferase EJ379_25045 ENOG4108ZB6 transcriptional regulator AsnC family EJ379_25050 ENOG4105C5I Dehydrogenase EJ379_25055 ENOG4108MUZ hydrolase EJ379_25065 ENOG4105C87 Aminotransferase class I and II EJ379_25075 ENOG4105Y38 Kinase-associated protein B EJ379_25085 ENOG4107R3E Citrate transporter EJ379_25105 ENOG4105KA0 thioesterase Superfamily protein EJ379_25120 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EJ379_25135 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EJ379_25140 ENOG41069ER domain protein EJ379_25155 ENOG4105CEP NADH dehydrogenase EJ379_25185 ENOG4105EWC Purine nucleoside phosphorylase EJ379_25210 ENOG4108YX9 iron--sulfur cluster insertion protein erpA EJ379_25215 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EJ379_25235 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EJ379_25240 ENOG4105C4B ABC transporter, permease EJ379_25245 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EJ379_25295 ENOG41083MR nifu domain-containing protein EJ379_25310 ENOG4108W5N phosphatidylglycerophosphatase a EJ379_25320 ENOG4105DYS nad(p)h dehydrogenase (quinone) EJ379_25325 ENOG4105D4U had-superfamily hydrolase, subfamily iia EJ379_25340 ENOG4105CBT Fructose-1,6-bisphosphatase EJ379_25360 ENOG4105MMD transcriptional regulator EJ379_25365 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) EJ379_25370 ENOG4107TXC Transcriptional regulator EJ379_25375 ENOG41090T1 Membrane EJ379_25400 ENOG4105FAA peptidase M23 EJ379_25405 ENOG4108YTE sporulation protein YunB EJ379_25410 ENOG4105KZD Domain of unknown function (DUF1805) EJ379_25415 ENOG4107R8B 5'-nucleotidase EJ379_25425 ENOG4105DIW FeS assembly protein SUFB EJ379_25430 ENOG4108UNV SUF system FeS assembly protein, NifU family EJ379_25435 ENOG4105C9B Cysteine desulfurase EJ379_25440 ENOG4105JRK feS assembly protein SufD EJ379_25445 ENOG4105C3K feS assembly ATPase SufC EJ379_25450 ENOG4105D01 (LipO)protein EJ379_25455 ENOG4105D01 (LipO)protein EJ379_25460 ENOG4108UMI ABC transporter, permease EJ379_25465 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EJ379_25490 ENOG41080E8 Transcriptional regulator, Spx MgsR family EJ379_25510 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EJ379_25535 ENOG4108W8B Beta-lactamase domain protein EJ379_25540 ENOG4105C1G acyl-Coa dehydrogenase EJ379_25545 ENOG4105CHU acetyl-coa acetyltransferase EJ379_25560 ENOG4105DZ1 carboxypeptidase EJ379_25580 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer EJ379_25590 ENOG4108SUT Major Facilitator Superfamily EJ379_25595 ENOG4107R7I amino acid EJ379_25610 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EJ379_25620 ENOG4107AYK membrAne EJ379_25660 ENOG4107ZTW SNARE associated Golgi EJ379_25670 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EJ379_25675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_25680 ENOG4105BZU Histidine kinase EJ379_25695 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EJ379_25710 ENOG4105C8Q Methyl-accepting chemotaxis EJ379_25715 ENOG4105VG1 fes assembly suf system protein EJ379_25720 ENOG4105D4Y metalloprotease EJ379_25740 ENOG4107T5V SNARE associated Golgi EJ379_25745 ENOG4107S91 Sodium hydrogen exchanger EJ379_25750 ENOG4105NCW Trka-c domain protein EJ379_25765 ENOG4108RMU ferritin dps family protein EJ379_25780 ENOG4108URH decarboxylase EJ379_25790 ENOG41090A1 ferritin EJ379_25800 ENOG4105D9N nucleoside EJ379_25805 ENOG4105D9N nucleoside EJ379_25820 ENOG4108RYK Nad-dependent epimerase dehydratase EJ379_25835 ENOG4105CV8 reductase EJ379_25840 ENOG4105F27 Major Facilitator EJ379_25845 ENOG4105KVH Transcriptional regulator EJ379_25860 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EJ379_25865 ENOG4105D4A Cell wall formation (By similarity) EJ379_25875 ENOG4105C8Q Methyl-accepting chemotaxis EJ379_25885 ENOG4105WMR Protein CrcB homolog EJ379_25890 ENOG4105WMR Protein CrcB homolog EJ379_25910 ENOG4105C5H ABC transporter EJ379_25915 ENOG4108MK9 spermidine N(1)-acetyltransferase EJ379_25925 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EJ379_25930 ENOG4105EMU Dehydrogenase EJ379_25940 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EJ379_25945 ENOG4108R85 Short chain dehydrogenase EJ379_26050 ENOG4108IPW abc transporter atp-binding protein EJ379_26055 ENOG4105CM4 permease protein EJ379_26070 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_26200 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EJ379_26210 ENOG4105XZU Preprotein translocase, subunit SecG EJ379_26215 ENOG41067MG lrgb family EJ379_26265 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ379_26285 ENOG41090VF Stage v sporulation protein ac EJ379_26290 ENOG4105CZ3 stage V sporulation protein ad EJ379_26305 ENOG4108QY0 Membrane EJ379_26315 ENOG4105KRI phosphocarrier protein (HPr EJ379_26325 ENOG4105CHW UPF0052 protein EJ379_26335 ENOG4108Z4K mutator MutT protein EJ379_26345 ENOG4105C3M thioredoxin reductase EJ379_26355 ENOG4108S4C acetyltransferase EJ379_26365 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) EJ379_26375 ENOG41086DT Membrane protein of unknown function EJ379_26385 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EJ379_26405 ENOG4107TXC Transcriptional regulator EJ379_26420 ENOG4105HMI Membrane EJ379_26425 ENOG4105DUM transcriptional regulator, lysR family EJ379_26435 ENOG4108WS4 fmn reductase EJ379_26455 ENOG4105BZ1 (ABC) transporter EJ379_26465 ENOG4105CN1 protease EJ379_26470 ENOG4105CRP Part of the ABC transporter FtsEX involved in EJ379_26475 ENOG4105CAK Cell division ATP-binding protein ftsE EJ379_26500 ENOG4105MS2 ribosomal subunit Interface protein EJ379_26505 ENOG4105VEQ Cold shock protein EJ379_26510 ENOG41081UC Inherit from COG: Competence protein EJ379_26540 ENOG4105KVH Transcriptional regulator EJ379_26550 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EJ379_26555 ENOG4108KGH TRANSCRIPTIONal EJ379_26560 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EJ379_26565 ENOG4105C6Y Udp-glucose 6-dehydrogenase EJ379_26570 ENOG4105ESV Glycosyl transferase, family 4 EJ379_26580 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EJ379_26600 ENOG4105F8D glycoside hydrolase family 4 EJ379_26605 ENOG4105VCP PTS System EJ379_26610 ENOG4105CK1 PTS System EJ379_26620 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EJ379_26625 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) EJ379_26630 ENOG4105VCP PTS System EJ379_26640 ENOG4105VZJ PTS System EJ379_26660 ENOG4105ECB domain protein EJ379_26665 ENOG4107RSM transcriptional regulator EJ379_26690 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EJ379_26695 ENOG4105DAA L-lactate EJ379_26705 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) EJ379_26720 ENOG4105E0M Sulfatase EJ379_26745 ENOG4107R8N Glycosyl transferase, family 2 EJ379_26750 ENOG4105C94 Transporter EJ379_26760 ENOG41069ER domain protein EJ379_26785 ENOG4105KBK Zinc finger, swim domain protein EJ379_26790 ENOG4105C0D helicase EJ379_26820 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ379_26835 ENOG4107RBB ABC transporter, permease EJ379_26840 ENOG4105C19 ABC transporter EJ379_26860 ENOG4105CXY transporter EJ379_26875 ENOG4105BZU Histidine kinase EJ379_26880 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_26885 ENOG4105CMR udp-glucose 4-epimerase EJ379_26895 ENOG4108KGH TRANSCRIPTIONal EJ379_26915 ENOG4107T8Q Glycosyl transferase (Group 1 EJ379_26925 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) EJ379_26930 ENOG4105CPF Cell wall formation (By similarity) EJ379_26935 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EJ379_26945 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EJ379_26950 ENOG4108RB3 Capsular polysaccharide biosynthesis protein EJ379_26955 ENOG4107YJ4 chain length determinant protein EJ379_26960 ENOG4105HTX biosynthesis protein EJ379_26965 ENOG4107YJ4 chain length determinant protein EJ379_26980 ENOG4105MT0 Sporulation transcriptional regulator spoiiid EJ379_26990 ENOG4105FRN stage II sporulation protein EJ379_27005 ENOG4105DY9 regulatoR EJ379_27025 ENOG4106778 Protein of unknown function (DUF1146) EJ379_27030 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJ379_27035 ENOG4105C8S subunit m EJ379_27040 ENOG4105D65 subunit l EJ379_27065 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJ379_27070 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EJ379_27080 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EJ379_27085 ENOG4105BZU Histidine kinase EJ379_27135 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) EJ379_27140 ENOG41062M3 atp synthase EJ379_27160 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EJ379_27165 ENOG4108UIC UPF0340 protein EJ379_27170 ENOG4108YZG isomerase EJ379_27185 ENOG4108VGI doxx family EJ379_27190 ENOG4107XC4 flavin reductase domain protein, FMN-binding EJ379_27205 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EJ379_27215 ENOG4108ZXQ stage ii sporulation protein r EJ379_27220 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EJ379_27225 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EJ379_27230 ENOG4107104 thymidine kinase EJ379_27240 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EJ379_27250 ENOG4105CBT Fructose-1,6-bisphosphatase EJ379_27255 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EJ379_27275 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EJ379_27290 ENOG4105C1G acyl-Coa dehydrogenase EJ379_27295 ENOG4105C1G acyl-Coa dehydrogenase EJ379_27300 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EJ379_27310 ENOG4105DF6 Fe-S oxidoreductase EJ379_27325 ENOG4105BZU Histidine kinase EJ379_27340 ENOG4105D4Y metalloprotease EJ379_27350 ENOG4105BZU Histidine kinase EJ379_27355 ENOG4105KCT ABC transporter EJ379_27360 ENOG4108M15 ABC transporter EJ379_27365 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) EJ379_27375 ENOG4105IIU Aminopeptidase EJ379_27395 ENOG4105DU6 RNA polymerase EJ379_27405 ENOG410684U Domain of unknown function (DUF1934) EJ379_27425 ENOG4105CYW agmatinase EJ379_27430 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EJ379_27435 ENOG4105DXB Major Facilitator superfamily EJ379_27440 ENOG4107SWG transcriptional regulator MERR family EJ379_27445 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EJ379_27450 ENOG4105BZ4 penicillin-binding protein EJ379_27455 ENOG4108XFG YwhD family EJ379_27460 ENOG4108Z4T Peptidase M50 EJ379_27465 ENOG41069HH 4-oxalocrotonate tautomerase EJ379_27470 ENOG4105DCI Phosphohydrolase EJ379_27475 ENOG4108MES Periplasmic binding protein EJ379_27480 ENOG4105E0A ABC, transporter EJ379_27485 ENOG4105EHG Permease protein EJ379_27490 ENOG4105DQ5 transport system permease protein EJ379_27500 ENOG4108VCI transcription factor, rsfa family EJ379_27505 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) EJ379_27510 ENOG4108IJ2 phosphate acetyltransferase EJ379_27525 ENOG4108VKI Cell wall hydrolase EJ379_27545 ENOG4107SVH Potassium channel protein EJ379_27555 ENOG410667J hydrolase EJ379_27560 ENOG4105VCH membrane EJ379_27570 ENOG4108TU7 Inherit from COG: (ABC) transporter EJ379_27575 ENOG4105CJ1 ABC, transporter EJ379_27580 ENOG41090WU lipolytic protein G-D-S-L family EJ379_27595 ENOG4105D6E homoserine dehydrogenase EJ379_27600 ENOG4105CVG Homoserine O-transsuccinylase EJ379_27620 ENOG4108Y4K DNA-binding transcriptional activator EJ379_27630 ENOG4105WH1 Two component transcriptional regulator luxr family EJ379_27635 ENOG4105BZU Histidine kinase EJ379_27640 ENOG4105DWF phosphomethylpyrimidine kinase EJ379_27645 ENOG4105BZU Histidine kinase EJ379_27650 ENOG4105VCD cytoplasmic protein EJ379_27655 ENOG4105D22 carbon starvation protein EJ379_27660 ENOG4105DY9 regulatoR EJ379_27665 ENOG41079KZ Major Facilitator Superfamily EJ379_27680 ENOG4105CG5 Glycosyl transferase (Group 1 EJ379_27690 ENOG4105EN6 Membrane EJ379_27695 ENOG4106YBV Methyl-accepting chemotaxis EJ379_27705 ENOG4108S4H thioesterase Superfamily protein EJ379_27710 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) EJ379_27725 ENOG4105K64 Glycosyl transferase, family 2 EJ379_27740 ENOG4105CKK Glycosyl transferase, family 2 EJ379_27745 ENOG4105C5H ABC transporter EJ379_27750 ENOG41067SE Tetr family transcriptional regulator EJ379_27760 ENOG4105E0X reductase EJ379_27765 ENOG4106F5Q Membrane EJ379_27775 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) EJ379_27780 ENOG4108NEV two component transcriptional regulator, LytTR family EJ379_27790 ENOG4107RGD Major Facilitator superfamily EJ379_27810 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EJ379_27820 ENOG4105IW1 AmiS UreI transporter EJ379_27830 ENOG4105CMR udp-glucose 4-epimerase EJ379_27835 ENOG4108UT2 hemolysin iii EJ379_27845 ENOG4105C1J atp-dependent rna helicase EJ379_27850 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) EJ379_27855 ENOG4105DPN Oligoendopeptidase f EJ379_27865 ENOG4105BZU Histidine kinase EJ379_27870 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) EJ379_27880 ENOG4105C0H protease EJ379_27885 ENOG4105Q2H domain protein EJ379_27900 ENOG4105BZU Histidine kinase EJ379_27905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_27930 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EJ379_27935 ENOG4105CDU Replicative dna helicase EJ379_27945 ENOG4105BZR domain protein EJ379_27950 ENOG4108XMW Membrane EJ379_27960 ENOG4108UUM single-stranded DNA-binding protein EJ379_27970 ENOG4105C3G gtp-binding protein EJ379_27975 ENOG4105VDK protein, conserved in bacteria EJ379_27980 ENOG4105D8X mechanosensitive ion channel EJ379_27985 ENOG4108ZDA Sporulation protein YyaC EJ379_27990 ENOG4105FA0 parb-like partition protein EJ379_27995 ENOG4107QJE Chromosome Partitioning Protein EJ379_28010 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EJ379_28015 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EJ379_28025 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EJ379_28065 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)