locus-tag class description BC_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BC_0003 ENOG410848D S4 domain protein YaaA BC_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BC_0013 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BC_0016 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BC_0022 ENOG4105GTG Isochorismatase BC_0023 ENOG4108Z6B deaminase BC_0024 ENOG4105C6E dna polymerase iii BC_0028 ENOG41067KS pro-sigma K processing BC_0035 ENOG4105CXN decarboxylase BC_0036 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BC_0037 ENOG4105FA2 dna polymerase iii BC_0038 ENOG4105MA4 psp1 domain protein BC_0040 ENOG41060K3 Methyltransferase BC_0041 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BC_0042 ENOG4105KRN Transcriptional regulator, abrb family BC_0043 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BC_0044 ENOG4105F8V Hydrolase, tatD family BC_0045 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BC_0047 ENOG4105XFA sporulation peptidase YabG BC_0048 ENOG4105W42 Veg protein BC_0051 ENOG4105DFT pur operon repressor BC_0052 ENOG4105KME endoribonuclease L-psp BC_0055 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BC_0056 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BC_0058 ENOG4108JA2 transcriptioN-repair coupling factor BC_0059 ENOG4108M14 stage v sporulation protein t BC_0061 ENOG4108IY2 MazG family BC_0062 ENOG41082I2 s4 domain protein BC_0063 ENOG4105VYY sporulation protein yabp BC_0066 ENOG41060GV RNA binding s1 domain protein BC_0070 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BC_0071 ENOG4108UGV hypoxanthine phosphoribosyltransferase BC_0072 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BC_0075 ENOG4105C6T cysteine synthase BC_0076 ENOG4105CRQ synthase (Component I) BC_0077 ENOG4105DDQ anthranilate synthase BC_0078 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BC_0079 ENOG4105EEI dihydropteroate synthase BC_0080 ENOG4105KRF dihydroneopterin aldolase BC_0081 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BC_0083 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BC_0100 ENOG4108Z0C Uvrb UvrC protein BC_0103 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BC_0104 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BC_0105 ENOG4105CTP PilT protein domain protein BC_0106 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BC_0109 ENOG4105D7W serine acetyltransferase BC_0112 ENOG4105C2N RNA methyltransferase TrmH family group 3 BC_0113 ENOG4105M0M Tetracycline resistance protein BC_0114 ENOG4105QIV RNA polymerase BC_0116 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BC_0117 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BC_0118 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BC_0119 ENOG4108VZM 50s ribosomal protein L10 BC_0121 ENOG4107Y49 methyltransferase BC_0124 ENOG4105XPM ribosomal protein BC_0131 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BC_0140 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BC_0146 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BC_0153 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BC_0155 ENOG41067V7 50S ribosomal protein L36 BC_0160 ENOG4108JJB ABC transporter BC_0161 ENOG4108JJB ABC transporter BC_0162 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BC_0163 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BC_0168 ENOG4105D1F ATP-binding protein BC_0171 ENOG4108NMV polysaccharide deacetylase BC_0186 ENOG4105C8B TIGR00159 family BC_0187 ENOG4107U5W ybbr family BC_0190 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BC_0195 ENOG4108PSK reductase BC_0196 ENOG4108UMI ABC transporter, permease BC_0197 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BC_0198 ENOG4105D01 (LipO)protein BC_0199 ENOG4105CB2 alcohol dehydrogenase BC_0201 ENOG4105IQ5 FAD linked oxidase domain protein BC_0204 ENOG4105C2C drug resistance transporter, Bcr CflA BC_0207 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BC_0208 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BC_0209 ENOG4105C3U ABC transporter BC_0210 ENOG4108JQ7 (ABC) transporter BC_0215 ENOG4108J59 Extracellular solute-binding protein, family 5 BC_0216 ENOG4108J59 Extracellular solute-binding protein, family 5 BC_0220 ENOG4105E0C molybdate abc transporter BC_0221 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BC_0222 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BC_0224 ENOG4105EGI Transcriptional regulator BC_0228 ENOG4105F6E Acyl-transferase BC_0232 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BC_0235 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BC_0239 ENOG4105C5H ABC transporter BC_0241 ENOG4105DEF Extracellular solute-binding protein, family 5 BC_0243 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BC_0244 ENOG4105C3U ABC transporter BC_0245 ENOG4108JQ7 (ABC) transporter BC_0246 ENOG410667J hydrolase BC_0252 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BC_0253 ENOG4105ERH Fumarylacetoacetate hydrolase BC_0255 ENOG4105CUB amino acid BC_0256 ENOG4108SC4 )-transporter BC_0257 ENOG4105CPF Cell wall formation (By similarity) BC_0258 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BC_0263 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BC_0264 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BC_0266 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BC_0286 ENOG4105K8N protein family UPF0079, ATPase BC_0287 ENOG41072GX Peptidase M22 Glycoprotease BC_0288 ENOG410801F ribosomal-protein-alanine acetyltransferase BC_0289 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BC_0290 ENOG4105C5H ABC transporter BC_0293 ENOG4108TYN CAAX amino terminal protease family protein BC_0295 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BC_0296 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BC_0297 ENOG4105C7N Xanthine uracil vitamin C permease BC_0299 ENOG4105BZU Histidine kinase BC_0304 ENOG4107ZXU DSBA oxidoreductase BC_0310 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BC_0312 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) BC_0314 ENOG4108SHN Glycosyl transferase, family 2 BC_0318 ENOG4105SX7 Transporter BC_0323 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BC_0324 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BC_0325 ENOG4105C83 adenylosuccinate lyase BC_0327 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BC_0329 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BC_0332 ENOG4108V3E phosphoribosylglycinamide formyltransferase BC_0333 ENOG4105DC1 bifunctional purine biosynthesis protein purh BC_0334 ENOG4105C12 Phosphoribosylglycinamide synthetase BC_0340 ENOG4105C4R Atp-dependent dna helicase BC_0341 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BC_0345 ENOG4108W2Y isochorismatase BC_0346 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BC_0347 ENOG4108UMI ABC transporter, permease BC_0348 ENOG4105D01 (LipO)protein BC_0349 ENOG4107I77 yiaA/B two helix domain BC_0351 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BC_0353 ENOG4105CBD Diacylglycerol kinase BC_0355 ENOG4108JPW Aminotransferase BC_0357 ENOG4105C26 Dehydrogenase BC_0358 ENOG4105KPY Small multidrug resistance protein BC_0363 ENOG4105D9N nucleoside BC_0364 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BC_0368 ENOG4108W15 Protein of unknown function (DUF1456) BC_0371 ENOG4105DTQ mandelate racemase muconate lactonizing BC_0373 ENOG4105DFD Na H antiporter BC_0377 ENOG4105D3R alkyl hydroperoxide reductase BC_0378 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BC_0379 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BC_0380 ENOG4107W7X Aldolase BC_0381 ENOG4105EHG Permease protein BC_0382 ENOG4105DQ5 transport system permease protein BC_0383 ENOG4108V5C ABC transporter BC_0385 ENOG4105CAY ferredoxin--nadp reductase BC_0389 ENOG4106UIA BC_0390 ENOG4106UIA BC_0393 ENOG4105BZU Histidine kinase BC_0397 ENOG410756H nucleotidyltransferase BC_0398 ENOG4105D2S major facilitator superfamily BC_0401 ENOG4105E5Q amino acid AbC transporter BC_0402 ENOG4105EAB amino acid AbC transporter BC_0403 ENOG4105CDA abc transporter atp-binding protein BC_0404 ENOG4105C8Q Methyl-accepting chemotaxis BC_0407 ENOG4105DBV ornithine carbamoyltransferase BC_0409 ENOG4105C5B carbamate kinase BC_0410 ENOG4108W63 CRP FNR family transcriptional regulator BC_0412 ENOG4105DNP FAD linked oxidase domain protein BC_0414 ENOG4105CI1 PTS System BC_0417 ENOG4105C9U ATP-dependent DNA helicase RecQ BC_0419 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BC_0420 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BC_0421 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BC_0425 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BC_0426 ENOG4105D2X ABC transporter substrate-binding protein BC_0428 ENOG4105C5H ABC transporter BC_0433 ENOG41062JF Transcriptional regulator BC_0436 ENOG4105DEU major facilitator superfamily BC_0439 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BC_0442 ENOG4108N0M stress protein BC_0443 ENOG4106FN3 tellurium resistance protein BC_0444 ENOG4106FN3 tellurium resistance protein BC_0445 ENOG4107TS3 membrane protein, TerC BC_0446 ENOG4108TTB tellurium resistance protein BC_0449 ENOG41068PA UPF0435 protein BC_0450 ENOG4105KJF protein tyrosine phosphatase BC_0452 ENOG4107U9T Pfam:Ribonuclease_BN BC_0453 ENOG4105C59 p-type ATPase BC_0454 ENOG4108IPJ Membrane BC_0456 ENOG4105C3F Signal peptidase i BC_0458 ENOG4107ZTW SNARE associated Golgi BC_0461 ENOG410606W general stress protein BC_0462 ENOG4105UPD Calcium Proton BC_0471 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BC_0473 ENOG4108JUB Transcriptional regulator BC_0483 ENOG4108A04 Beta-lactamase BC_0486 ENOG4105CKK Glycosyl transferase, family 2 BC_0487 ENOG4107QQG Dehydrogenase BC_0488 ENOG4105C3I Nad-dependent epimerase dehydratase BC_0492 ENOG4105F1A Pyruvate formate-lyase BC_0493 ENOG4108QBV Monogalactosyldiacylglycerol synthase BC_0496 ENOG4105CI2 imidazolone-5-propionate hydrolase BC_0497 ENOG4105ECP epimerase BC_0503 ENOG41067AE Membrane-bound metal-dependent hydrolase BC_0504 ENOG4105CEN a g-specific adenine glycosylase BC_0505 ENOG4106BXE BC_0509 ENOG4105BZ1 (ABC) transporter BC_0510 ENOG4107NBY Membrane BC_0511 ENOG4105CBC glutamate synthase BC_0513 ENOG4108IUW ABC transporter BC_0517 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BC_0518 ENOG4105G5W regulator Fur family BC_0539 ENOG4105CDY transcriptional regulatory protein BC_0541 ENOG4108JQC penicillin-binding protein 1A BC_0542 ENOG4108R9S DSBA oxidoreductase BC_0544 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BC_0546 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BC_0547 ENOG4105BZU Histidine kinase BC_0548 ENOG4105CYN Serine protein kinase BC_0551 ENOG4106AKX UPF0229 protein BC_0555 ENOG4105C94 Transporter BC_0558 ENOG4105DZ6 Band 7 protein BC_0560 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BC_0561 ENOG4108V9W transcriptional regulatory protein BC_0562 ENOG4105D4T Citrate transporter BC_0566 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BC_0567 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BC_0568 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BC_0569 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BC_0570 ENOG4105BZ7 extracellular solute-binding protein family 1 BC_0571 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BC_0572 ENOG4108STX response regulator BC_0573 ENOG4105US7 Histidine kinase BC_0578 ENOG4108MRH transcriptional regulatory protein BC_0580 ENOG4105C6K Malic enzyme BC_0582 ENOG4108UZ3 Transporter BC_0583 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BC_0585 ENOG4105BZU Histidine kinase BC_0587 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BC_0588 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BC_0589 ENOG4108JB9 formate dehydrogenase BC_0593 ENOG4105CUB amino acid BC_0596 ENOG4105C59 p-type ATPase BC_0597 ENOG4105DAP Nicotinate phosphoribosyltransferase BC_0606 ENOG41073R8 VanW family BC_0607 ENOG4108KGH TRANSCRIPTIONal BC_0608 ENOG4105D9N nucleoside BC_0609 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BC_0610 ENOG4105C37 (CBS) domain BC_0611 ENOG4108IJ0 Aspartate ammonia-lyase BC_0612 ENOG4105DAA L-lactate BC_0615 ENOG4105DUX Transporter BC_0616 ENOG4108MES Periplasmic binding protein BC_0618 ENOG4108IHU transport system permease protein BC_0619 ENOG4105E0A ABC, transporter BC_0621 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BC_0622 ENOG4105EXW epimerase dehydratase BC_0624 ENOG4107T89 von Willebrand factor, type A BC_0625 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BC_0626 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BC_0628 ENOG4105BZU Histidine kinase BC_0629 ENOG4105D5Q Arginine ornithine antiporter BC_0630 ENOG4107414 GntR family transcriptional regulator BC_0631 ENOG4105C5Y PTS System BC_0632 ENOG4105CG3 alpha amylase, catalytic region BC_0635 ENOG4105E1K spore germination protein BC_0637 ENOG4105CRN Aminoglycoside phosphotransferase BC_0638 ENOG4105BZG amino acid carrier protein BC_0639 ENOG4105CDA abc transporter atp-binding protein BC_0640 ENOG4105CT1 (ABC) transporter BC_0641 ENOG4105EAD ABC transporter BC_0642 ENOG4105DRP amino acid AbC transporter BC_0643 ENOG4108IQI permease BC_0649 ENOG4105D29 Helix-turn-helix type 11 domain protein BC_0650 ENOG4105NAE bifunctional deaminase-reductase domain protein BC_0651 ENOG4105BZU Histidine kinase BC_0654 ENOG4105CHH sulfate transporter BC_0655 ENOG41068KF Universal stress protein BC_0656 ENOG4105CXY transporter BC_0657 ENOG41067TZ transcriptional regulator, MarR family BC_0658 ENOG4105C0R drug resistance transporter emrb qaca subfamily BC_0659 ENOG4105ETE Transcriptional regulator (LacI family BC_0660 ENOG4108RVA ribokinase BC_0661 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BC_0662 ENOG4105C2J ABC transporter BC_0663 ENOG4105CNN ABC, transporter BC_0665 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BC_0671 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) BC_0677 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BC_0678 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BC_0679 ENOG41069ER domain protein BC_0680 ENOG4105VZ8 Transcriptional regulator BC_0681 ENOG4107D63 BC_0684 ENOG4105DUX Transporter BC_0688 ENOG4105C85 amino acid BC_0689 ENOG4105C7N Xanthine uracil vitamin C permease BC_0692 ENOG4105MA6 gCN5-related N-acetyltransferase BC_0697 ENOG4105BZ9 Cytochrome C oxidase, subunit I BC_0698 ENOG4105E2S oxidase) subunit II BC_0702 ENOG4106CAD Protein of unknown function (DUF3311) BC_0703 ENOG4105E1V na solute symporter BC_0706 ENOG4108NHD germination protein BC_0707 ENOG4105CE1 Ferrous iron transport protein b BC_0708 ENOG4105CE1 Ferrous iron transport protein b BC_0709 ENOG4105CE1 Ferrous iron transport protein b BC_0710 ENOG4105CVA phosphate BC_0711 ENOG4105C8U phosphate abc transporter BC_0712 ENOG4105E2Z phosphate ABC transporter (Permease BC_0737 ENOG41080XQ Signal transduction protein with cbs domains BC_0742 ENOG4105ETU transcriptional activator (TenA BC_0744 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BC_0746 ENOG4108VEU Thiamine monophosphate synthase BC_0747 ENOG41080HI glycine oxidase BC_0749 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BC_0750 ENOG4105D06 uba thif-type nad fad binding protein BC_0751 ENOG4105DWF phosphomethylpyrimidine kinase BC_0754 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BC_0755 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) BC_0758 ENOG4108INS Transcriptional regulator BC_0764 ENOG4105C19 ABC transporter BC_0766 ENOG4105CNN ABC, transporter BC_0769 ENOG4105C7N Xanthine uracil vitamin C permease BC_0775 ENOG4105C5Y PTS System BC_0778 ENOG4105K63 Thioredoxin BC_0782 ENOG4108B31 Spore germination protein BC_0786 ENOG4107Y03 Nitroreductase BC_0787 ENOG4105ED1 spovr family BC_0789 ENOG4108TCS Glutamyl endopeptidase BC_0791 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BC_0792 ENOG4105XTG Pfam:DUF156 BC_0793 ENOG4105VFE sira family BC_0794 ENOG4107TPS domain protein BC_0795 ENOG4105VFE sira family BC_0796 ENOG4105VFE sira family BC_0797 ENOG41085GJ domain protein BC_0798 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BC_0799 ENOG41087NI Sulfite exporter TauE/SafE BC_0801 ENOG4108KGH TRANSCRIPTIONal BC_0806 ENOG4105EMD TRANSCRIPTIONal BC_0807 ENOG4105VCP PTS System BC_0808 ENOG4105VZJ PTS System BC_0813 ENOG41069ER domain protein BC_0814 ENOG4107RBB ABC transporter, permease BC_0815 ENOG4105C19 ABC transporter BC_0821 ENOG4105WEF catalase BC_0828 ENOG4107T5V SNARE associated Golgi BC_0838 ENOG4107RWR Sodium hydrogen exchanger BC_0840 ENOG4106KNT transcriptional regulator BC_0841 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BC_0848 ENOG4108YXU transcriptional regulator AsnC family BC_0849 ENOG4105CH7 arginosuccinase BC_0850 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BC_0852 ENOG4105KPY Small multidrug resistance protein BC_0859 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BC_0860 ENOG4105E5W Transporter BC_0862 ENOG4107RKG DJ-1/PfpI family BC_0863 ENOG4105CH6 catalase BC_0865 ENOG4105D5Q Arginine ornithine antiporter BC_0866 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BC_0868 ENOG4105C26 Dehydrogenase BC_0870 ENOG4105BZ1 (ABC) transporter BC_0871 ENOG4105BZ1 (ABC) transporter BC_0873 ENOG4105DRP amino acid AbC transporter BC_0874 ENOG4105CDA abc transporter atp-binding protein BC_0877 ENOG410839P BC_0879 ENOG4108UH6 UPF0754 membrane protein BC_0881 ENOG4105BZU Histidine kinase BC_0882 ENOG4105WH1 Two component transcriptional regulator luxr family BC_0884 ENOG4107FQX Alpha-acetolactate decarboxylase BC_0885 ENOG4108VX5 3-methyladenine DNA glycosylase BC_0888 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BC_0889 ENOG4105D4P Coproporphyrinogen iii oxidase BC_0890 ENOG4105CEY Amp-dependent synthetase and ligase BC_0893 ENOG4105CHH sulfate transporter BC_0898 ENOG4105CGU Enoyl-CoA hydratase BC_0901 ENOG4105DER m42 family BC_0905 ENOG4105CTU Proline racemase BC_0906 ENOG4105CIF Ornithine Cyclodeaminase BC_0909 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BC_0911 ENOG4108JQ7 (ABC) transporter BC_0920 ENOG4108IBT Inherit from COG: transposase BC_0935 ENOG4105CSH Transporter BC_0937 ENOG4108MRH transcriptional regulatory protein BC_0945 ENOG4105VTR Integrase BC_0956 ENOG4105CDU Replicative dna helicase BC_0962 ENOG4105C0R drug resistance transporter emrb qaca subfamily BC_0964 ENOG4105D9U N-acetyltransferase BC_0968 ENOG4105F6J Alpha beta hydrolase fold BC_0976 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BC_0979 ENOG4105CMT Dihydroxyacetone kinase BC_0981 ENOG4105CMT Dihydroxyacetone kinase BC_1002 ENOG4105WN5 stage II sporulation protein BC_1004 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BC_1006 ENOG4108MJI response regulator BC_1007 ENOG4105BZU Histidine kinase BC_1008 ENOG4105BZU Histidine kinase BC_1012 ENOG4105K8R UPF0145 protein BC_1015 ENOG4107QHE Choloylglycine hydrolase BC_1019 ENOG4107VRP DNA repair exonuclease BC_1020 ENOG4106D4I domain protein BC_1023 ENOG410829K Lysine exporter protein (Lyse ygga) BC_1027 ENOG4108MUZ hydrolase BC_1031 ENOG4105F0F Oxalate decarboxylase BC_1032 ENOG41067QW Transcriptional regulator BC_1033 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BC_1036 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BC_1041 ENOG4105EEM helicase BC_1043 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BC_1049 ENOG4105K59 histidine triad (HIT) protein BC_1055 ENOG410905X membrane-flanked domain protein BC_1056 ENOG4105CKV Membrane BC_1064 ENOG410905X membrane-flanked domain protein BC_1065 ENOG4105CKV Membrane BC_1066 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BC_1067 ENOG4105BZ4 penicillin-binding protein BC_1069 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BC_1070 ENOG4105C1Q protoporphyrinogen oxidase BC_1075 ENOG4105NA0 Transcriptional regulator BC_1078 ENOG4105ECB domain protein BC_1082 ENOG4108MK9 spermidine N(1)-acetyltransferase BC_1084 ENOG4106AXD BC_1085 ENOG4108RQ5 Beta-lactamase domain-containing protein BC_1086 ENOG4105DF9 Lipoate-protein, ligase BC_1088 ENOG4105CEY Amp-dependent synthetase and ligase BC_1090 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BC_1091 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BC_1092 ENOG4108I5D sulfate abc transporter BC_1093 ENOG4105ECW sulfate abc transporter BC_1094 ENOG4108IJ6 ABC transporter BC_1110 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) BC_1111 ENOG4107RN3 metallophosphoesterase BC_1112 ENOG4107TVP HD domain protein BC_1114 ENOG4108AEY RNA polymerase sigma factor BC_1115 ENOG41086D8 Transcriptional regulator BC_1119 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BC_1123 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BC_1124 ENOG4105C8Q Methyl-accepting chemotaxis BC_1125 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) BC_1127 ENOG4107QP3 malate synthase g BC_1131 ENOG4105VEQ Cold shock protein BC_1137 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BC_1138 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BC_1147 ENOG4105ERH Fumarylacetoacetate hydrolase BC_1149 ENOG4105C8Y Acetylornithine aminotransferase BC_1150 ENOG4106BKT UPF0344 protein BC_1152 ENOG4105CAQ asparagine synthetase BC_1153 ENOG4105CAQ asparagine synthetase BC_1154 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BC_1155 ENOG4105CH6 catalase BC_1156 ENOG4105BZU Histidine kinase BC_1159 ENOG4108VPT UPF0234 protein BC_1160 ENOG4105QNR S1 RNA binding domain protein BC_1161 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BC_1163 ENOG4107AYK membrAne BC_1164 ENOG41073B9 BC_1165 ENOG4108KP7 hydrolase BC_1168 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BC_1173 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BC_1174 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BC_1180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BC_1181 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BC_1183 ENOG4108JQ7 (ABC) transporter BC_1184 ENOG4105UQX Mate efflux family protein BC_1189 ENOG4108ZCF integral membrane protein BC_1191 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BC_1193 ENOG4105DPN Oligoendopeptidase f BC_1195 ENOG4108Z18 K06886 hemoglobin BC_1196 ENOG4105MIX Adenylate cyclase BC_1197 ENOG4106EFP UPF0738 protein BC_1199 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BC_1200 ENOG4105EMS pseudouridine synthase BC_1204 ENOG4105K64 Glycosyl transferase, family 2 BC_1208 ENOG4107TVC Glycosyl transferase, family 2 BC_1212 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BC_1213 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BC_1215 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BC_1225 ENOG4108ZMI UPF0477 protein BC_1231 ENOG4105CK7 Sodium proline symporter BC_1232 ENOG4105CRQ synthase (Component I) BC_1233 ENOG4105DDQ anthranilate synthase BC_1234 ENOG4108I0Q anthranilate phosphoribosyltransferase BC_1235 ENOG4105DK0 Indole-3-glycerol phosphate synthase BC_1236 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BC_1237 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BC_1238 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BC_1251 ENOG4105C7S Dehydrogenase BC_1252 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BC_1253 ENOG4105VZ8 Transcriptional regulator BC_1264 ENOG4108NE4 BC_1267 ENOG4108R1P BC_1272 ENOG4105VTR Integrase BC_1277 ENOG4105DZ1 carboxypeptidase BC_1278 ENOG4105VFR signal peptidase BC_1285 ENOG4105C26 Dehydrogenase BC_1286 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BC_1287 ENOG4105F38 ABC transporter, permease BC_1288 ENOG4105D38 putrescine abc transporter BC_1289 ENOG4107RUE extracellular solute-binding protein family 1 BC_1291 ENOG4105EYF MMPL domain protein BC_1293 ENOG4108YBP pseudouridine synthase BC_1295 ENOG4105K4I Scp-like extracellular BC_1296 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BC_1297 ENOG4105CQB FAD linked oxidase domain protein BC_1300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BC_1301 ENOG4105BZU Histidine kinase BC_1302 ENOG4105JXH GntR family transcriptional regulator BC_1306 ENOG4106A3R peptidase BC_1308 ENOG4108QTI )-transporter BC_1309 ENOG4107TS3 membrane protein, TerC BC_1310 ENOG4105CZN Potassium uptake protein BC_1311 ENOG410681C small acid-soluble spore protein BC_1312 ENOG4108Z7G MaoC domain protein dehydratase BC_1317 ENOG4105CHR reductase BC_1323 ENOG4105C4Y ABC transporter BC_1324 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BC_1325 ENOG4107RCV ABC transporter, permease BC_1326 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BC_1329 ENOG4105E98 transcriptional regulator DeoR family BC_1334 ENOG4105PXI polysaccharide deacetylase BC_1336 ENOG4105BZU Histidine kinase BC_1337 ENOG41090MY MarR family Transcriptional regulator BC_1339 ENOG4106DF1 BC_1340 ENOG4105BZU Histidine kinase BC_1341 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BC_1342 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BC_1343 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BC_1353 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BC_1354 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BC_1355 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BC_1356 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BC_1357 ENOG4105CZV ABC transporter BC_1359 ENOG4105CJ1 ABC, transporter BC_1367 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BC_1368 ENOG4105EA8 2-Nitropropane dioxygenase BC_1369 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BC_1371 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BC_1376 ENOG4105NQC Flavodoxin BC_1384 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BC_1390 ENOG4105CZN Potassium uptake protein BC_1391 ENOG41063Y9 BC_1392 ENOG4105KBJ sporulation protein ytfj BC_1396 ENOG4105CM2 brancheD-chain amino acid aminotransferase BC_1398 ENOG4108ZP8 Acetolactate synthase small subunit BC_1399 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BC_1402 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BC_1403 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BC_1404 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BC_1405 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BC_1406 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BC_1407 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BC_1408 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BC_1409 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BC_1410 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BC_1411 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BC_1412 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase BC_1413 ENOG4107RVV histidinol phosphate phosphatase, hisj family BC_1416 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BC_1417 ENOG4105E0M Sulfatase BC_1419 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BC_1422 ENOG4107S4M Sulfate adenylate transferase BC_1423 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BC_1424 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BC_1426 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BC_1427 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BC_1428 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BC_1430 ENOG4105C8J )-transporter BC_1434 ENOG4105DFD Na H antiporter BC_1438 ENOG4105ENE Histidine kinase BC_1439 ENOG4105WH1 Two component transcriptional regulator luxr family BC_1443 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BC_1448 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BC_1453 ENOG4105CJ3 phosphate transporter BC_1454 ENOG4107GRR phosphate transport regulator BC_1455 ENOG4105BZ4 penicillin-binding protein BC_1458 ENOG4105BZU Histidine kinase BC_1459 ENOG4105I3N Conserved Protein BC_1463 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BC_1468 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BC_1469 ENOG4105DZ1 carboxypeptidase BC_1470 ENOG4108JIC nucleoside recognition domain protein BC_1472 ENOG4105FE9 pseudouridine synthase BC_1473 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BC_1474 ENOG4107TWT Cytochrome c biogenesis protein BC_1475 ENOG4107TWT Cytochrome c biogenesis protein BC_1476 ENOG4105CRE cytochrome C BC_1477 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BC_1478 ENOG4105BZU Histidine kinase BC_1479 ENOG4108WBT adenosyltransferase BC_1482 ENOG4108SAX Membrane BC_1485 ENOG4105C9U ATP-dependent DNA helicase RecQ BC_1486 ENOG4105I7S Abortive infection protein BC_1488 ENOG4107RGJ metallophosphoesterase BC_1489 ENOG4108XDN Transcriptional regulator BC_1490 ENOG4108S6Z Negative regulator of genetic competence BC_1495 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BC_1496 ENOG4107RB3 L-asparaginase BC_1499 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BC_1502 ENOG4105S2F BC_1503 ENOG41065D1 BC_1509 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BC_1512 ENOG4105XXQ heptaprenyl diphosphate synthase component I BC_1514 ENOG4105EAH synthase BC_1515 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BC_1516 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BC_1517 ENOG4105D49 3-dehydroquinate synthase BC_1519 ENOG41068YB TPR repeat-containing protein BC_1522 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BC_1523 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BC_1530 ENOG4108JYZ YitT family BC_1531 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BC_1532 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BC_1534 ENOG4105FJR Lmbe family BC_1535 ENOG4105CPK Glycosyl transferase (Group 1 BC_1540 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BC_1541 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BC_1544 ENOG4105YAC BC_1548 ENOG4105CSM endonuclease III BC_1550 ENOG4105BZ4 penicillin-binding protein BC_1553 ENOG4105BZ4 penicillin-binding protein BC_1561 ENOG4106F55 Protein of unknown function (DUF1273) BC_1563 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BC_1565 ENOG4105DVT helicase BC_1566 ENOG4105CTD carboxy-peptidase BC_1568 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BC_1569 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BC_1570 ENOG4105C2W permease BC_1571 ENOG4105DHF Membrane BC_1572 ENOG410890F Dynamin family BC_1574 ENOG4108W0I acetyltransferase BC_1576 ENOG4105KHC sulfurtransferase BC_1584 ENOG4105HTX biosynthesis protein BC_1590 ENOG4105CPK Glycosyl transferase (Group 1 BC_1593 ENOG4108SZE gCN5-related N-acetyltransferase BC_1597 ENOG41081VK Ribonuclease BC_1610 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BC_1612 ENOG4107RWR Sodium hydrogen exchanger BC_1613 ENOG4105CN5 Metallo-Beta-Lactamase BC_1614 ENOG4108Z5V transcriptional regulator, merr family BC_1616 ENOG4105H67 Protein of unknown function (DUF421) BC_1617 ENOG41080C8 DUF218 domain BC_1623 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BC_1625 ENOG4107R0U MotA TolQ exbB proton channel BC_1626 ENOG4105ER2 Ompa motb domain protein BC_1627 ENOG4107YTP response regulator receiver protein BC_1628 ENOG4105CBS Chea signal transduction histidine kinase BC_1629 ENOG4105DD5 Flagellar motor switch protein BC_1632 ENOG4105BZU Histidine kinase BC_1636 ENOG4105E1Q flagellar hook-associated protein BC_1637 ENOG4105DTJ flagellar hook-associated protein BC_1638 ENOG4107TPX flagellar hook-associated BC_1641 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BC_1642 ENOG4108ZC9 flagellar basal-body rod protein flgc BC_1643 ENOG41075Z6 flagellar hook-basal body complex protein fliE BC_1644 ENOG4107U2N Flagellar M-ring protein BC_1645 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BC_1651 ENOG4105BZE flagellar hook protein, FlgE BC_1654 ENOG4107R88 Chemotaxis protein (CheV) BC_1656 ENOG4105I03 Flagellin BC_1657 ENOG4105I03 Flagellin BC_1658 ENOG4105I03 Flagellin BC_1659 ENOG4105I03 Flagellin BC_1660 ENOG4105E4C Lytic transglycosylase catalytic BC_1662 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BC_1663 ENOG4105DD5 Flagellar motor switch protein BC_1665 ENOG4105CN7 Flagellar biosynthetic protein FliP BC_1666 ENOG4105VS8 Flagellar biosynthetic protein fliq BC_1668 ENOG4105D00 flagellar biosynthetic protein flhB BC_1671 ENOG4105KTQ flagellar basal-body rod protein BC_1672 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BC_1678 ENOG4105KAC Antibiotic biosynthesis monooxygenase BC_1683 ENOG4105DUM transcriptional regulator, lysR family BC_1691 ENOG4105CVJ phosphoglycerate mutase BC_1693 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BC_1697 ENOG4105CAQ asparagine synthetase BC_1701 ENOG4105PGM cation diffusion facilitator family transporter BC_1703 ENOG4105DRR Transcriptional regulator, GntR family BC_1704 ENOG4108UZ3 Transporter BC_1705 ENOG4105CKI cobalamin synthesis protein BC_1706 ENOG4108PJD permease BC_1709 ENOG4105DFD Na H antiporter BC_1710 ENOG4105VUF Transcriptional regulator BC_1712 ENOG4105C9Q fumarate hydratase class II BC_1716 ENOG4107QJQ Mate efflux family protein BC_1717 ENOG4105EC3 peptidase S51, dipeptidase E BC_1721 ENOG4107QIV Cytochrome c biogenesis protein BC_1725 ENOG4105BZC d-serine deaminase BC_1726 ENOG4106BRA Membrane BC_1734 ENOG4105CJ1 ABC, transporter BC_1738 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BC_1740 ENOG4108IJ0 Aspartate ammonia-lyase BC_1741 ENOG4105C6K Malic enzyme BC_1751 ENOG4105FVX BC_1752 ENOG4105E09 nadh pyrophosphatase BC_1755 ENOG4105CSR polyphosphate kinase 2 BC_1756 ENOG4105U3E Transcriptional regulator BC_1759 ENOG4105DXI Major Facilitator superfamily BC_1761 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BC_1762 ENOG4105EU0 Major facilitator Superfamily BC_1763 ENOG4105C6T cysteine synthase BC_1767 ENOG4105C8J )-transporter BC_1769 ENOG4105X5K response regulator receiver protein BC_1770 ENOG4105H67 Protein of unknown function (DUF421) BC_1774 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BC_1776 ENOG4105CM2 brancheD-chain amino acid aminotransferase BC_1777 ENOG4105C7K acetolactate synthase BC_1779 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BC_1780 ENOG4105C01 Dihydroxy-acid dehydratase BC_1781 ENOG4105C7B Threonine dehydratase BC_1786 ENOG4105C6X Major Facilitator BC_1787 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BC_1789 ENOG4105DY9 regulatoR BC_1790 ENOG4105CYC Transferase BC_1793 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BC_1799 ENOG41068WN BC_1800 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BC_1803 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BC_1804 ENOG4105C72 UPF0176 protein BC_1806 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BC_1807 ENOG4105C0X amino acid BC_1815 ENOG410849A acetyltransferase, (GNAT) family BC_1816 ENOG4105K8R UPF0145 protein BC_1819 ENOG4107RHR regulatoR BC_1821 ENOG4105D9N nucleoside BC_1822 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BC_1823 ENOG4105KG3 cytidine deaminase BC_1824 ENOG4105IYK transposase BC_1825 ENOG4105DQ6 Transposase BC_1828 ENOG4107RAQ aminopeptidase BC_1830 ENOG4107R16 Multicopper oxidase BC_1838 ENOG4108T5E Copper resistance protein BC_1839 ENOG4105KTB nuclear export factor GLE1 BC_1840 ENOG4107RT3 EamA-like transporter family BC_1841 ENOG4105GZI Transcriptional regulator BC_1842 ENOG4108Z40 Transcriptional regulator BC_1843 ENOG4107ZXU DSBA oxidoreductase BC_1844 ENOG4108TVJ Nitroreductase BC_1846 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BC_1864 ENOG4105C2M dna polymerase I BC_1884 ENOG4105KRN Transcriptional regulator, abrb family BC_1911 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis BC_1922 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BC_1923 ENOG4106F5Q Membrane BC_1924 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BC_1926 ENOG4105CKI cobalamin synthesis protein BC_1928 ENOG4105C0Z ABC transporter BC_1929 ENOG4108IV0 ABC, transporter BC_1930 ENOG4105C32 Amino acid ABC transporter (Permease) BC_1932 ENOG4105SKE transcriptional Regulator LysR family BC_1936 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BC_1938 ENOG4105C4M (Ubiquinol oxidase) subunit I BC_1939 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BC_1940 ENOG4108JJ9 ABC, transporter BC_1941 ENOG4108JJ8 (ABC) transporter BC_1943 ENOG4105K64 Glycosyl transferase, family 2 BC_1945 ENOG4108UT6 Transferase hexapeptide repeat containing protein BC_1955 ENOG4105BZ1 (ABC) transporter BC_1956 ENOG4105EFI regulatoR BC_1957 ENOG4105BZU Histidine kinase BC_1959 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BC_1960 ENOG4108ZJ4 polysaccharide deacetylase BC_1964 ENOG4105D6E homoserine dehydrogenase BC_1966 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BC_1969 ENOG4108KGH TRANSCRIPTIONal BC_1972 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BC_1973 ENOG4105BZU Histidine kinase BC_1974 ENOG4107VMI polysaccharide deacetylase BC_1976 ENOG4105KT7 mgtC SapB transporter BC_1977 ENOG4105VRR gCN5-related N-acetyltransferase BC_1979 ENOG4105DUU IucA IucC family protein BC_1980 ENOG4105CEY Amp-dependent synthetase and ligase BC_1983 ENOG4108WBH protein TIM barrel BC_1984 ENOG4105YWU small acid-soluble spore protein BC_1986 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BC_1987 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BC_1996 ENOG4105KRN Transcriptional regulator, abrb family BC_1998 ENOG4105YVS arsR family transcriptional regulator BC_1999 ENOG4105CPC Aldo Keto reductase BC_2001 ENOG4105KAF membrAne BC_2006 ENOG4105C8Q Methyl-accepting chemotaxis BC_2010 ENOG4108K88 Membrane BC_2011 ENOG4108WPJ Ferritin-like domain BC_2014 ENOG4105DEN Luciferase family BC_2017 ENOG4105VMI -acetyltransferase BC_2018 ENOG4107QM2 Aldo Keto reductase BC_2019 ENOG4105CKI cobalamin synthesis protein BC_2021 ENOG4105DSE periplasmic solute binding protein BC_2022 ENOG4105K4T epimerase BC_2023 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BC_2024 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BC_2033 ENOG4107T5V SNARE associated Golgi BC_2036 ENOG4108PJD permease BC_2038 ENOG4108S4H thioesterase Superfamily protein BC_2039 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BC_2043 ENOG4105SXS Protein of unknown function (DUF456) BC_2044 ENOG4105C37 (CBS) domain BC_2048 ENOG4108Z7R Chaperone CsaA BC_2050 ENOG4108ZRV stage ii sporulation protein p BC_2052 ENOG4108VXD carboxy-peptidase BC_2054 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BC_2058 ENOG4108ZRV stage ii sporulation protein p BC_2060 ENOG4108X4Q Hydrolase BC_2063 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BC_2066 ENOG41087PP glycosyltransferase MGT family BC_2067 ENOG4108JYZ YitT family BC_2068 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BC_2074 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BC_2078 ENOG4106PAW secretion accessory protein EsaA YueB BC_2080 ENOG4108MGT Required for secretion of EsxA and EsxB BC_2095 ENOG4105KBJ sporulation protein ytfj BC_2100 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BC_2101 ENOG4105CKU formyltetrahydrofolate synthetase BC_2104 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BC_2105 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BC_2107 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BC_2108 ENOG4105EMN RNA polymerase sigma factor BC_2110 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BC_2114 ENOG4108V06 Glutathione peroxidase BC_2117 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BC_2119 ENOG4108IUE nitrate reductase beta subunit BC_2120 ENOG4105R3A Nitrate reductase BC_2122 ENOG4107V6Q Cyclic nucleotide-binding domain BC_2123 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BC_2124 ENOG4105D06 uba thif-type nad fad binding protein BC_2125 ENOG4105CVM Molybdenum cofactor synthesis domain protein BC_2126 ENOG4108ZAF Molybdopterin BC_2132 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BC_2133 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BC_2134 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BC_2135 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BC_2136 ENOG4108IFG nitrite reductase, (NAD(P)H) BC_2137 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BC_2142 ENOG4105MCT stage V sporulation protein S BC_2151 ENOG4105C5H ABC transporter BC_2154 ENOG4108UUM single-stranded DNA-binding protein BC_2158 ENOG4107YX5 Pfam:DUF548 BC_2164 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BC_2169 ENOG4105C5S asparaginyl-tRNA synthetase BC_2170 ENOG4105C8J )-transporter BC_2174 ENOG4107XGZ Hydrolase BC_2175 ENOG4105CY2 Citrate transporter BC_2179 ENOG4105KD7 acetyltransferase BC_2181 ENOG4105VMP Transcriptional regulator BC_2182 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BC_2187 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BC_2190 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BC_2191 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BC_2193 ENOG4107RVG penicillin-binding protein BC_2194 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BC_2195 ENOG4105E9Q Acyl-transferase BC_2196 ENOG4108UT2 hemolysin iii BC_2198 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BC_2200 ENOG4108RCR degv family BC_2202 ENOG4108KF3 Electron transport protein SCO1 SenC BC_2203 ENOG4107Y70 Heat shock protein BC_2204 ENOG4105CAQ asparagine synthetase BC_2207 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BC_2208 ENOG4108MES Periplasmic binding protein BC_2209 ENOG4105F0I Aminotransferase BC_2215 ENOG4105D8X mechanosensitive ion channel BC_2216 ENOG4105BZU Histidine kinase BC_2217 ENOG4105WH1 Two component transcriptional regulator luxr family BC_2218 ENOG4106KNT transcriptional regulator BC_2219 ENOG4107ZY0 Phenazine biosynthesis-like protein BC_2223 ENOG4105CMG Carbohydrate kinase BC_2224 ENOG4105C6Z Gluconate BC_2226 ENOG4108YV3 Protein of unknown function (DUF2711) BC_2232 ENOG4108IJ8 ABC transporter BC_2233 ENOG4105E90 ABC transporter BC_2240 ENOG4105C37 (CBS) domain BC_2245 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BC_2248 ENOG4107S4Y M20 DapE family protein YgeY BC_2249 ENOG4108TSC N-acetyltransferase BC_2250 ENOG4108JUB Transcriptional regulator BC_2251 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BC_2260 ENOG410841Q phosphoesterase PA-phosphatase related protein BC_2262 ENOG4105SZ6 Thioredoxin BC_2263 ENOG4105KNA -acetyltransferase BC_2272 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BC_2281 ENOG4105BZ4 penicillin-binding protein BC_2283 ENOG4105CZM Major Facilitator BC_2284 ENOG4105W8X HesB YadR YfhF-family protein BC_2286 ENOG4105DXD 2-methylcitrate dehydratase BC_2287 ENOG4105CR4 methylisocitrate lyase BC_2288 ENOG4105C1G acyl-Coa dehydrogenase BC_2289 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BC_2291 ENOG4105N14 lysine exporter protein LysE YggA BC_2292 ENOG4105E39 Enoyl-CoA hydratase BC_2295 ENOG4107RFY SbcCD D subunit BC_2296 ENOG4105EYH Exonuclease BC_2300 ENOG4105FCD Major Facilitator BC_2302 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BC_2303 ENOG4105E4F Isochorismate synthase BC_2304 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BC_2305 ENOG4105WQI isochorismatase BC_2306 ENOG4105CEY Amp-dependent synthetase and ligase BC_2307 ENOG4105CEY Amp-dependent synthetase and ligase BC_2308 ENOG4105CEY Amp-dependent synthetase and ligase BC_2309 ENOG4105WQT MbtH domain protein BC_2310 ENOG4105C0R drug resistance transporter emrb qaca subfamily BC_2313 ENOG4105K70 DNA-binding protein BC_2317 ENOG4105BZG amino acid carrier protein BC_2321 ENOG4105FE9 pseudouridine synthase BC_2322 ENOG4105C22 threonyL-tRNA synthetase BC_2323 ENOG4105C19 ABC transporter BC_2330 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BC_2333 ENOG41081I9 integral membrane protein BC_2335 ENOG4108Y4K DNA-binding transcriptional activator BC_2339 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BC_2342 ENOG4105DQ6 Transposase BC_2343 ENOG4105IYK transposase BC_2349 ENOG4105WCN acetyltransferase BC_2354 ENOG4105C1Q protoporphyrinogen oxidase BC_2356 ENOG41068WN BC_2362 ENOG4107V2S Transcriptional regulator BC_2363 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BC_2367 ENOG4105DND Transcriptional regulator BC_2368 ENOG4108RPX mosc domain containing protein BC_2371 ENOG4105BZ1 (ABC) transporter BC_2372 ENOG4105BZ1 (ABC) transporter BC_2379 ENOG4108JCI Transcriptional regulator BC_2385 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BC_2386 ENOG4108KPJ rna polymerase sigma factor BC_2392 ENOG4105F32 YngK protein BC_2396 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BC_2397 ENOG4105RD7 BadF BadG BcrA BcrD BC_2398 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BC_2399 ENOG4107STF Involved in phosphonate degradation (By similarity) BC_2400 ENOG4105C7B Threonine dehydratase BC_2401 ENOG4108INS Transcriptional regulator BC_2406 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BC_2408 ENOG4105C1J atp-dependent rna helicase BC_2410 ENOG4108RZE Tetr family transcriptional regulator BC_2430 ENOG41088CC tellurite resistance protein tehB BC_2432 ENOG4108I0C methyltransferase BC_2433 ENOG4107RA9 decarboxylase BC_2434 ENOG4105K56 Transcriptional regulator BC_2435 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BC_2439 ENOG4105CIN aminoacyl-histidine dipeptidase BC_2444 ENOG4105KRN Transcriptional regulator, abrb family BC_2446 ENOG4105EJ9 Membrane BC_2447 ENOG4105EQK -acetyltransferase BC_2451 ENOG4105C0W non-ribosomal peptide synthetase BC_2457 ENOG4105W8Z 4'-phosphopantetheinyl transferase BC_2467 ENOG4105FQP Beta-lactamase BC_2468 ENOG4107RVG penicillin-binding protein BC_2471 ENOG4107RF6 penicillin-binding protein BC_2474 ENOG4108MK9 spermidine N(1)-acetyltransferase BC_2476 ENOG4105DIN metallophosphoesterase BC_2478 ENOG4105CJ1 ABC, transporter BC_2480 ENOG4107Z3H Transcriptional regulator, TetR family BC_2484 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BC_2485 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BC_2486 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BC_2487 ENOG4105E39 Enoyl-CoA hydratase BC_2488 ENOG4107QX3 carboxylase BC_2489 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BC_2490 ENOG4105IYK transposase BC_2491 ENOG4105DQ6 Transposase BC_2496 ENOG4105DZ1 carboxypeptidase BC_2499 ENOG4105T9C HD domain BC_2503 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BC_2507 ENOG41075H3 AraC family transcriptional regulator BC_2513 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BC_2515 ENOG4107Y80 Major Facilitator superfamily BC_2516 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BC_2517 ENOG4105KVH Transcriptional regulator BC_2529 ENOG4105CPQ Dehydrogenase BC_2531 ENOG410900G Protein of unknown function (DUF421) BC_2532 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BC_2534 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BC_2535 ENOG4105DK7 lysyl-tRNA synthetase BC_2548 ENOG4105D6E homoserine dehydrogenase BC_2550 ENOG4105CPF Cell wall formation (By similarity) BC_2551 ENOG4105ETU transcriptional activator (TenA BC_2556 ENOG4105VTR Integrase BC_2599 ENOG4105XSJ toxin secretion phage lysis holin BC_2613 ENOG4106A3M Cytochrome p-450 BC_2618 ENOG410667J hydrolase BC_2619 ENOG4105BZU Histidine kinase BC_2620 ENOG4107RF6 penicillin-binding protein BC_2625 ENOG4108FPN Integrase BC_2629 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BC_2632 ENOG41086D8 Transcriptional regulator BC_2638 ENOG4108NHD germination protein BC_2640 ENOG4108W2Y isochorismatase BC_2643 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BC_2645 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BC_2646 ENOG4105EKQ RNA-directed DNA polymerase BC_2655 ENOG4108JJB ABC transporter BC_2660 ENOG4105CB2 alcohol dehydrogenase BC_2661 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BC_2662 ENOG4105CJN penicillin-binding protein BC_2671 ENOG4108V4B ThiJ pfpI BC_2673 ENOG4107Y80 Major Facilitator superfamily BC_2676 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BC_2681 ENOG4107Y9U Membrane BC_2689 ENOG4105FCD Major Facilitator BC_2692 ENOG4105E09 nadh pyrophosphatase BC_2693 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BC_2697 ENOG4105KME endoribonuclease L-psp BC_2698 ENOG4108XI2 Domain of unknown function (DUF1963) BC_2704 ENOG4108NRW Phospholipase, patatin family BC_2705 ENOG4105KWG Pfam:DUF1696 BC_2708 ENOG4108YYS metal-dependent hydrolase (By similarity) BC_2711 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BC_2713 ENOG4105PKS Excinuclease abc c subunit domain protein BC_2719 ENOG4105CJ1 ABC, transporter BC_2723 ENOG4107VFR oxidoreductase BC_2730 ENOG4105U0R haloacid dehalogenase-like hydrolase BC_2734 ENOG4108IUM Glycogen debranching enzyme BC_2739 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BC_2740 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BC_2741 ENOG4105FDR Membrane BC_2743 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BC_2752 ENOG4105MSI germination protein ypeb BC_2758 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BC_2759 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BC_2760 ENOG4107Z3H Transcriptional regulator, TetR family BC_2766 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BC_2770 ENOG4105E98 transcriptional regulator DeoR family BC_2773 ENOG41062ES Transcriptional regulator BC_2777 ENOG4107QKR Dehydrogenase BC_2779 ENOG4107RUY (E1 component), alpha subunit BC_2781 ENOG4105E1F short-chain dehydrogenase reductase BC_2782 ENOG4105RHY Pfam:UPF0157 BC_2790 ENOG4107SQ8 Glycine betaine BC_2791 ENOG4108IJ7 Glycine betaine BC_2793 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BC_2796 ENOG4105E66 phosphoriboisomerase A BC_2797 ENOG41082BV acetyltransferase BC_2798 ENOG4108M1A Chitin-binding protein BC_2803 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BC_2804 ENOG4105MSB protein, conserved in bacteria BC_2809 ENOG4108Z7F N-acetyltransferase BC_2815 ENOG4105C9U ATP-dependent DNA helicase RecQ BC_2821 ENOG4105DQ6 Transposase BC_2827 ENOG4108M1A Chitin-binding protein BC_2831 ENOG4105BZG amino acid carrier protein BC_2832 ENOG4105C26 Dehydrogenase BC_2833 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BC_2834 ENOG4105CTU Proline racemase BC_2835 ENOG4105CTU Proline racemase BC_2836 ENOG41080HI glycine oxidase BC_2838 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BC_2846 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BC_2850 ENOG4105DTQ mandelate racemase muconate lactonizing BC_2853 ENOG4107SET aldo keto reductase BC_2861 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BC_2862 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BC_2863 ENOG4105BZU Histidine kinase BC_2864 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BC_2870 ENOG4105DPN Oligoendopeptidase f BC_2871 ENOG4105EPR degv family BC_2884 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BC_2885 ENOG4106K7D Major facilitator family transporter BC_2888 ENOG4107BMA Transglycosylase associated protein BC_2891 ENOG41089UC methyltransferase, type 11 BC_2896 ENOG4105CHM Aminotransferase BC_2902 ENOG4105DVE abc transporter atp-binding protein BC_2907 ENOG4105C02 permease BC_2909 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BC_2910 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BC_2911 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BC_2912 ENOG4105D7T ABC transporter BC_2919 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BC_2926 ENOG4107VC0 DNA alkylation repair enzyme BC_2927 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BC_2929 ENOG4107VMI polysaccharide deacetylase BC_2931 ENOG4108ZCF integral membrane protein BC_2932 ENOG4105E0M Sulfatase BC_2933 ENOG4105C5H ABC transporter BC_2936 ENOG41082JN Transcriptional regulator BC_2940 ENOG4105CIH Imidazole acetol-phosphate transaminase BC_2941 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BC_2942 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BC_2952 ENOG41069ER domain protein BC_2954 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BC_2960 ENOG4105D4B ABC, transporter BC_2961 ENOG4105F5R ABC transporter BC_2962 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BC_2964 ENOG4105DKT Transcriptional regulator BC_2965 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BC_2967 ENOG41061GT Aldolase BC_2969 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BC_2975 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BC_2977 ENOG4105II7 pyrroline-5-carboxylate reductase BC_2979 ENOG4107258 Transcriptional regulator BC_2983 ENOG4105ECK Fatty Acid Desaturase BC_2985 ENOG4107RBI VanW family BC_2986 ENOG4105G6Z alkaline phosphatase BC_2988 ENOG4105VMP Transcriptional regulator BC_2992 ENOG41068WN BC_2997 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BC_3001 ENOG4105CKK Glycosyl transferase, family 2 BC_3007 ENOG4105C8Y Acetylornithine aminotransferase BC_3018 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BC_3021 ENOG4108IBT Inherit from COG: transposase BC_3024 ENOG4108TVJ Nitroreductase BC_3025 ENOG4105FS7 Transcriptional regulator BC_3028 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BC_3031 ENOG4105CMR udp-glucose 4-epimerase BC_3033 ENOG4108DMH HTH_ARAC BC_3034 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BC_3035 ENOG4108XET gCN5-related N-acetyltransferase BC_3040 ENOG4107XJU UPF0178 protein BC_3050 ENOG410635A Membrane BC_3052 ENOG4108IQI permease BC_3054 ENOG4105F1N DNA alkylation repair BC_3061 ENOG4107RF6 penicillin-binding protein BC_3062 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BC_3063 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BC_3066 ENOG4105E7W lamb ycsf family protein BC_3068 ENOG4105P4J Allophanate hydrolase, subunit 1 BC_3069 ENOG4107258 Transcriptional regulator BC_3071 ENOG4106N3A copper homeostasis protein cutc BC_3072 ENOG4108ZHR arsR family transcriptional regulator BC_3077 ENOG4105DWD nucleoside recognition domain protein BC_3087 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BC_3092 ENOG4105E2A Dehydrogenase BC_3093 ENOG4108IJ0 Aspartate ammonia-lyase BC_3094 ENOG4105HDK L-asparaginase BC_3095 ENOG4108IMY Transcriptional regulator BC_3098 ENOG4108B31 Spore germination protein BC_3100 ENOG4105BZU Histidine kinase BC_3105 ENOG41075H3 AraC family transcriptional regulator BC_3106 ENOG4105YWU small acid-soluble spore protein BC_3107 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BC_3108 ENOG4105CUB amino acid BC_3109 ENOG4105II7 pyrroline-5-carboxylate reductase BC_3110 ENOG4108NHD germination protein BC_3111 ENOG4108Q8B Spore germination protein BC_3118 ENOG4106A3M Cytochrome p-450 BC_3121 ENOG4105CGH 5'-nucleotidase BC_3123 ENOG4105CHJ isochorismatase hydrolase BC_3128 ENOG41090MY MarR family Transcriptional regulator BC_3133 ENOG4105F6J Alpha beta hydrolase fold BC_3136 ENOG4108606 TspO/MBR family BC_3137 ENOG4105CVP deoxyribo-dipyrimidine photolyase BC_3141 ENOG4105EVH UPF0753 protein BC_3142 ENOG4108TWJ NADH dehydrogenase subunit 5 BC_3143 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BC_3144 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BC_3148 ENOG4105KY5 gCN5-related N-acetyltransferase BC_3149 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BC_3150 ENOG4105ECQ AraC Family Transcriptional Regulator BC_3151 ENOG4105Z7P Acetyltransferase (GNAT) family BC_3152 ENOG4108SY2 LMWPc BC_3153 ENOG4105D6J arsenicaL-resistance protein BC_3154 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BC_3155 ENOG41085FC arsR family transcriptional regulator BC_3158 ENOG4105NAE bifunctional deaminase-reductase domain protein BC_3159 ENOG4107P5I polyketide synthase BC_3160 ENOG4108IG5 Transcriptional regulator BC_3162 ENOG4105EQ0 Major Facilitator superfamily BC_3163 ENOG4108JGH Tetr family transcriptional regulator BC_3165 ENOG4105XRQ Xanthine dehydrogenase accessory factor BC_3174 ENOG4105CHR reductase BC_3175 ENOG4108YXU transcriptional regulator AsnC family BC_3189 ENOG4105C44 Serine transporter BC_3190 ENOG4105DUM transcriptional regulator, lysR family BC_3191 ENOG4105DWP Membrane BC_3200 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BC_3201 ENOG41062D9 Histidine kinase BC_3211 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BC_3212 ENOG4105C0R drug resistance transporter emrb qaca subfamily BC_3216 ENOG4105K6H D-cysteine desulfhydrase BC_3219 ENOG4105JQZ Methyltransferase BC_3223 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BC_3227 ENOG4105BZU Histidine kinase BC_3229 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BC_3231 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BC_3240 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BC_3243 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BC_3245 ENOG4105DVH amino acid BC_3248 ENOG4108JQ1 Dehydrogenase BC_3249 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BC_3252 ENOG41082W1 Cupin 2, conserved barrel domain protein BC_3253 ENOG410874W AraC family transcriptional regulator BC_3257 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BC_3307 ENOG4108VXD carboxy-peptidase BC_3308 ENOG4105PNM synthesis protein BC_3310 ENOG4108ISG Major Facilitator BC_3313 ENOG4107MII Sugar-specific transcriptional regulator TrmB BC_3314 ENOG4105CZM Major Facilitator BC_3316 ENOG4108Z66 YbaK ebsC protein BC_3317 ENOG4105CUT histidyl-tRNA synthetase BC_3320 ENOG4105KVH Transcriptional regulator BC_3321 ENOG4108RCM Nitroreductase BC_3327 ENOG4108PSK reductase BC_3340 ENOG4105C31 Tryptophanyl-tRNA synthetase BC_3341 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BC_3347 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BC_3349 ENOG4105EV4 Multidrug resistance protein mdtH BC_3355 ENOG4105C37 (CBS) domain BC_3358 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BC_3359 ENOG4105FAW cDP-glucose 4,6-dehydratase BC_3366 ENOG4105DDN Pentapeptide repeat-containing protein BC_3367 ENOG4105XDF Protein of unknown function (DUF1272) BC_3368 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BC_3369 ENOG4105CMG Carbohydrate kinase BC_3370 ENOG4105C6Z Gluconate BC_3377 ENOG4105CIS alcohol dehydrogenase BC_3378 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BC_3382 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BC_3385 ENOG4105C8Q Methyl-accepting chemotaxis BC_3386 ENOG4108UX3 '-nucleotidase BC_3387 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BC_3388 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BC_3389 ENOG4105KVH Transcriptional regulator BC_3392 ENOG4105CV8 reductase BC_3393 ENOG4105F27 Major Facilitator BC_3395 ENOG41090KN UPF0303 protein BC_3398 ENOG4105C44 Serine transporter BC_3404 ENOG4105KVH Transcriptional regulator BC_3405 ENOG4108TZY GntR Family Transcriptional Regulator BC_3406 ENOG4105D9R oxidoreductase BC_3407 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BC_3408 ENOG4105KVH Transcriptional regulator BC_3409 ENOG4105KVH Transcriptional regulator BC_3418 ENOG4105JAB phenazine biosynthesis protein, phzf family BC_3420 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BC_3421 ENOG4105KVH Transcriptional regulator BC_3439 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BC_3441 ENOG4107YXZ hydrolase, family 25 BC_3447 ENOG4105H3G oxidoreductase BC_3461 ENOG4108TN2 lmbE family BC_3463 ENOG4107R3E Citrate transporter BC_3465 ENOG4105WCN acetyltransferase BC_3466 ENOG4108MES Periplasmic binding protein BC_3467 ENOG4105EHG Permease protein BC_3468 ENOG4105DQ5 transport system permease protein BC_3469 ENOG4105NX3 Membrane BC_3473 ENOG41068WN BC_3474 ENOG4107CUJ Protein of unknown function (DUF2690) BC_3476 ENOG4107V2S Transcriptional regulator BC_3480 ENOG4105C98 muts2 protein BC_3482 ENOG4105E5K Alpha-amylase BC_3483 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BC_3484 ENOG4105DPN Oligoendopeptidase f BC_3490 ENOG4108A04 Beta-lactamase BC_3495 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BC_3497 ENOG41082BM Transcriptional regulator, arsr family BC_3498 ENOG4105CIS alcohol dehydrogenase BC_3499 ENOG4105CNG UPF0061 protein BC_3504 ENOG4105CQB FAD linked oxidase domain protein BC_3509 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BC_3511 ENOG4107TPS domain protein BC_3512 ENOG4105CEP NADH dehydrogenase BC_3514 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BC_3516 ENOG4108IAJ Nad-dependent epimerase dehydratase BC_3517 ENOG4105FAW cDP-glucose 4,6-dehydratase BC_3522 ENOG41067SE Tetr family transcriptional regulator BC_3523 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity BC_3525 ENOG4107DUR UPF0457 protein BC_3528 ENOG4105BZU Histidine kinase BC_3530 ENOG4105KT7 mgtC SapB transporter BC_3532 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BC_3533 ENOG41073R8 VanW family BC_3535 ENOG4108R1P BC_3539 ENOG4105VEQ Cold shock protein BC_3543 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BC_3548 ENOG410904N short-chain dehydrogenase reductase BC_3550 ENOG4106IQC argininosuccinate lyase BC_3553 ENOG4108IA2 Sodium pantothenate symporter BC_3555 ENOG4105C26 Dehydrogenase BC_3556 ENOG4105CHR reductase BC_3557 ENOG4105EWU Squalene--hopene cyclase BC_3559 ENOG4105FR1 rard protein BC_3560 ENOG410696E Membrane BC_3563 ENOG4105D1F ATP-binding protein BC_3565 ENOG4108ZAF Molybdopterin BC_3566 ENOG4105CVM Molybdenum cofactor synthesis domain protein BC_3568 ENOG4105TMB Formate nitrite transporter BC_3570 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BC_3571 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BC_3573 ENOG4108JB9 formate dehydrogenase BC_3574 ENOG4105E1K spore germination protein BC_3577 ENOG4105CUB amino acid BC_3587 ENOG4108KGH TRANSCRIPTIONal BC_3589 ENOG4105EMN RNA polymerase sigma factor BC_3591 ENOG4105CIG ABC transporter BC_3595 ENOG4105D9R oxidoreductase BC_3597 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BC_3599 ENOG4105K4P CoA-binding domain protein BC_3600 ENOG4105C0H protease BC_3601 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BC_3603 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BC_3604 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BC_3605 ENOG4105W8X HesB YadR YfhF-family protein BC_3611 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BC_3612 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BC_3616 ENOG4108I0Z Aconitate hydratase BC_3622 ENOG4105E5W Transporter BC_3628 ENOG4107F3J Amp-dependent synthetase and ligase BC_3629 ENOG4107ZYJ bioY protein BC_3630 ENOG4105CEY Amp-dependent synthetase and ligase BC_3631 ENOG4105CEY Amp-dependent synthetase and ligase BC_3639 ENOG4107AYK membrAne BC_3641 ENOG4105BZU Histidine kinase BC_3642 ENOG4105FBA Phospholipase Carboxylesterase BC_3643 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BC_3644 ENOG4105CK7 Sodium proline symporter BC_3646 ENOG4105CBC glutamate synthase BC_3647 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BC_3648 ENOG4108VJ1 Transcriptional regulator (CarD family BC_3650 ENOG4105CI2 imidazolone-5-propionate hydrolase BC_3651 ENOG4105CGP Urocanate hydratase BC_3652 ENOG4105C84 Histidine ammonia-lyase BC_3662 ENOG4107QIV Cytochrome c biogenesis protein BC_3664 ENOG4105CH2 amidohydrolase BC_3666 ENOG4105CJ1 ABC, transporter BC_3668 ENOG4107RSM transcriptional regulator BC_3669 ENOG4105VAW lrga family BC_3670 ENOG41067MG lrgb family BC_3678 ENOG4105BZ1 (ABC) transporter BC_3679 ENOG4105BZ1 (ABC) transporter BC_3686 ENOG4108HW3 (ABC) transporter BC_3687 ENOG4105CGH 5'-nucleotidase BC_3689 ENOG4108SVB resolvase BC_3693 ENOG4105K7K Transcriptional regulator BC_3694 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BC_3698 ENOG4105E4C Lytic transglycosylase catalytic BC_3699 ENOG41065S2 pneumococcal vaccine antigen BC_3704 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BC_3706 ENOG4105KV4 Transcriptional regulator BC_3707 ENOG4105CXI aluminum resistance protein BC_3708 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BC_3709 ENOG4105EN6 Membrane BC_3718 ENOG4105DM4 PTS System BC_3719 ENOG4105DE4 1-phosphofructokinase BC_3720 ENOG4105E98 transcriptional regulator DeoR family BC_3721 ENOG4107QW4 alcohol dehydrogenase BC_3722 ENOG4108SJC Membrane BC_3724 ENOG4105C85 amino acid BC_3727 ENOG4105TMB Formate nitrite transporter BC_3728 ENOG4105K70 DNA-binding protein BC_3730 ENOG4105C59 p-type ATPase BC_3731 ENOG410681U heavy metal transport detoxification protein BC_3732 ENOG4105VPX protein, conserved in bacteria BC_3734 ENOG4105NIV Esterase BC_3735 ENOG4105E0A ABC, transporter BC_3739 ENOG4105CGK Exodeoxyribonuclease III BC_3741 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BC_3742 ENOG4105D03 DNA-3-methyladenine glycosylase II BC_3743 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BC_3747 ENOG4105BZU Histidine kinase BC_3754 ENOG41067MG lrgb family BC_3759 ENOG4105CS2 ec 3.2.1.21 BC_3760 ENOG4105CS2 ec 3.2.1.21 BC_3765 ENOG4105E0M Sulfatase BC_3766 ENOG410890F Dynamin family BC_3772 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BC_3773 ENOG4105DQU oxidoreductase, subunit beta BC_3774 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BC_3775 ENOG4108IGT Dipeptidase BC_3776 ENOG4105MCT stage V sporulation protein S BC_3777 ENOG4105D48 metallophosphoesterase BC_3780 ENOG4105CEV competence damage-inducible protein BC_3781 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BC_3784 ENOG4105XZV Protein of unknown function (DUF3243) BC_3785 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BC_3790 ENOG4108JQ9 ABC transporter BC_3791 ENOG4105DIH basic membrane BC_3792 ENOG4105FDP GntR family transcriptional regulator BC_3793 ENOG4105CNU cell division protein FtsK BC_3795 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BC_3797 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BC_3799 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BC_3800 ENOG4108S0H Dipicolinic acid synthetase, b subunit BC_3801 ENOG4105E35 Dipicolinate synthase subunit A BC_3803 ENOG4105C1V Peptidase, M16 BC_3805 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BC_3807 ENOG4105DTN riboflavin biosynthesis protein ribF BC_3810 ENOG4105W7A Protein of unknown function (DUF503) BC_3812 ENOG4105VHM ribosomal protein BC_3813 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BC_3814 ENOG4105CHV Transcription elongation factor NusA BC_3816 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BC_3817 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BC_3819 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BC_3820 ENOG4105KNE Phosphatidate cytidylyltransferase BC_3821 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BC_3823 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BC_3829 ENOG4108HE4 integrase family BC_3830 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BC_3831 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BC_3832 ENOG4105C79 DNA protecting protein DprA BC_3833 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BC_3835 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BC_3836 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BC_3841 ENOG4105VB6 UPF0109 protein BC_3845 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BC_3846 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BC_3849 ENOG4105CHR reductase BC_3850 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BC_3851 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BC_3853 ENOG4105CB5 ATP-dependent DNA helicase recG BC_3854 ENOG4105DP4 dak2 domain fusion protein ylov BC_3855 ENOG4108ZAA Alkaline-shock protein BC_3857 ENOG4105FJ0 thiamine BC_3858 ENOG4105DJV ribulose-phosphate 3-epimerase BC_3859 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BC_3860 ENOG4105D9P serine threonine protein kinase BC_3861 ENOG4108ZF3 Phosphatase BC_3862 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BC_3863 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BC_3864 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BC_3866 ENOG4105C25 Primosomal protein n' BC_3867 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BC_3871 ENOG4105DSJ YicC domain protein BC_3873 ENOG4105F23 Fibronectin-binding protein BC_3875 ENOG4105DC7 peptidase M24 BC_3882 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BC_3885 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BC_3886 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BC_3887 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BC_3888 ENOG4105CD3 dihydroorotase BC_3892 ENOG4105C34 Pseudouridine synthase BC_3895 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BC_3897 ENOG4105DBK s4 domain protein BC_3898 ENOG41067XK integral membrane protein BC_3900 ENOG4105DFA alanine racemase domain protein BC_3901 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BC_3902 ENOG4105WR5 sporulation protein, YlmC YmxH family BC_3904 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BC_3906 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BC_3907 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BC_3909 ENOG4105D4A Cell wall formation (By similarity) BC_3910 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BC_3911 ENOG4105CNI cell division protein FtsW BC_3912 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BC_3914 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BC_3915 ENOG4105CJN penicillin-binding protein BC_3916 ENOG4105CJN penicillin-binding protein BC_3919 ENOG41074B2 UPF0747 protein BC_3924 ENOG4105KNH Nucleic acid-binding protein BC_3926 ENOG41063PX domain protein BC_3927 ENOG4105D78 K07001 NTE family protein BC_3928 ENOG4105H20 Sporulation integral membrane protein YlbJ BC_3930 ENOG4106H78 methyltransferase BC_3934 ENOG4107TB6 phosphoglycerate mutase BC_3937 ENOG4106UY4 Inherit from COG: Scp-like extracellular BC_3946 ENOG4107VFP cytochrome oxidase assembly BC_3947 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BC_3948 ENOG4105CNI cell division protein FtsW BC_3951 ENOG4108IAB Phoh family BC_3955 ENOG4105QA2 BC_3956 ENOG4105CI3 gtp-binding protein typa BC_3958 ENOG4105ECY inositol monophosphatase BC_3962 ENOG4105CXN decarboxylase BC_3972 ENOG4105CPP Dehydrogenase, E1 component BC_3974 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BC_3975 ENOG4108X4Q Hydrolase BC_3977 ENOG4105CN5 Metallo-Beta-Lactamase BC_3978 ENOG4107ZYR domain protein BC_3980 ENOG4105CH2 amidohydrolase BC_3985 ENOG4108XRC Protein of unknown function (DUF458) BC_3986 ENOG4107IN1 Protein of unknown function (DUF1797) BC_3989 ENOG4105EPM Diguanylate phosphodiesterase BC_3990 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BC_3993 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BC_3995 ENOG4105UIN BC_4003 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BC_4007 ENOG4108HGU Histidine kinase BC_4009 ENOG4105CHM Aminotransferase BC_4010 ENOG4105FKQ transcriptional regulator BC_4011 ENOG4105EG2 ABC transporter, permease BC_4015 ENOG4105CG3 alpha amylase, catalytic region BC_4023 ENOG4105CHU acetyl-coa acetyltransferase BC_4029 ENOG4105K7K Transcriptional regulator BC_4030 ENOG4105DTD Dehydrogenase BC_4033 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BC_4034 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BC_4036 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BC_4037 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BC_4039 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BC_4042 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BC_4044 ENOG4105BZU Histidine kinase BC_4048 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BC_4051 ENOG4105CID antiterminator BC_4053 ENOG4105FDP GntR family transcriptional regulator BC_4055 ENOG4105CE4 GlcNAc 6-P deacetylase BC_4057 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BC_4061 ENOG4107ZE5 PPIases accelerate the folding of proteins BC_4062 ENOG4105PTM secreted protein BC_4063 ENOG4105J7I hydrolase BC_4065 ENOG4105G6R Stage v sporulation protein ae BC_4067 ENOG4105CZ3 stage V sporulation protein ad BC_4068 ENOG41090VF Stage v sporulation protein ac BC_4071 ENOG4105C8J )-transporter BC_4072 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BC_4074 ENOG41082AN stage II sporulation protein BC_4075 ENOG4105DZ1 carboxypeptidase BC_4076 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BC_4077 ENOG4105DVE abc transporter atp-binding protein BC_4084 ENOG4105D7N magnesium and cobalt transport protein CorA BC_4089 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BC_4091 ENOG4105I3K Ferric uptake regulator, Fur family BC_4092 ENOG4105MZ9 stage II sporulation protein m BC_4096 ENOG4105CPC Aldo Keto reductase BC_4098 ENOG4105RHY Pfam:UPF0157 BC_4102 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BC_4104 ENOG4105ETE Transcriptional regulator (LacI family BC_4105 ENOG4108YM7 Gcn5-related n-acetyltransferase BC_4109 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BC_4110 ENOG4108R6K riboflavin synthase, subunit alpha BC_4111 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BC_4114 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BC_4115 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BC_4116 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BC_4118 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BC_4119 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BC_4121 ENOG4105DFD Na H antiporter BC_4126 ENOG4105DBV ornithine carbamoyltransferase BC_4129 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BC_4133 ENOG41069FQ Metallo-beta-lactamase superfamily BC_4134 ENOG4105II7 pyrroline-5-carboxylate reductase BC_4135 ENOG4105EJQ L-serine dehydratase BC_4138 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BC_4140 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BC_4143 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BC_4144 ENOG4105D9U N-acetyltransferase BC_4146 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BC_4147 ENOG4108QEG Membrane BC_4148 ENOG4105CDA abc transporter atp-binding protein BC_4149 ENOG4105E5Q amino acid AbC transporter BC_4150 ENOG4108HW3 (ABC) transporter BC_4152 ENOG4105G7B Protein of unknown function (DUF2992) BC_4153 ENOG4105E09 nadh pyrophosphatase BC_4154 ENOG4108QY0 Membrane BC_4157 ENOG4105C7S Dehydrogenase BC_4158 ENOG4105CPP Dehydrogenase, E1 component BC_4161 ENOG4105CKM Branched-chain carboxylic acid kinase BC_4162 ENOG4107RDP Dehydrogenase BC_4165 ENOG4108JUB Transcriptional regulator BC_4167 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BC_4170 ENOG4107QQR Sporulation BC_4172 ENOG4105S1Z Stage IV sporulation protein B BC_4174 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BC_4175 ENOG4105DX0 Hemolysin A BC_4177 ENOG4105CTB Polyprenyl synthetase BC_4180 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BC_4182 ENOG4108ZSR alkaline shock protein BC_4183 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BC_4188 ENOG410644B Stage III sporulation protein af BC_4190 ENOG4105KQ4 Stage iii sporulation protein ad BC_4191 ENOG4108CQH stage III sporulation protein AC BC_4192 ENOG4105KR5 Stage iii sporulation protein BC_4193 ENOG4105CD2 stage iii sporulation protein aa BC_4198 ENOG4105DC7 peptidase M24 BC_4199 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BC_4201 ENOG4105CBJ Metal-dependent enzyme BC_4203 ENOG4107YBY Hydrolase BC_4209 ENOG41082GG biotin lipoate A B protein ligase BC_4210 ENOG4105WZW rhodanese family BC_4214 ENOG41080TC multidrug resistance protein BC_4221 ENOG4105CJ1 ABC, transporter BC_4222 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BC_4224 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BC_4227 ENOG4105C0D helicase BC_4242 ENOG4107R6U sodium dicarboxylate symporter BC_4249 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BC_4250 ENOG4105C3R Methionine synthase BC_4253 ENOG4105C28 cystathionine BC_4254 ENOG4105C28 cystathionine BC_4258 ENOG4105C5X domain protein BC_4260 ENOG4105DKQ ROK family BC_4262 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BC_4265 ENOG4108UTW Plays a role in the regulation of phosphate uptake BC_4266 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BC_4267 ENOG4105C8U phosphate abc transporter BC_4268 ENOG4105C8U phosphate abc transporter BC_4269 ENOG4105EXS phosphate abc transporter BC_4270 ENOG4107RF6 penicillin-binding protein BC_4277 ENOG4105N80 Ferric uptake regulator, Fur family BC_4279 ENOG4105FDK ABC transporter BC_4280 ENOG4108JYZ YitT family BC_4281 ENOG41069ZM Protein of unknown function (DUF2624) BC_4286 ENOG4105EGD dinuclear metal center protein, YbgI family BC_4289 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BC_4290 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BC_4293 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BC_4297 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BC_4298 ENOG4105KG3 cytidine deaminase BC_4299 ENOG4107YR5 Diacylglycerol kinase BC_4300 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BC_4301 ENOG4105CTJ Metal Dependent Phosphohydrolase BC_4302 ENOG4105C9A Phoh family BC_4304 ENOG41068P3 sporulation protein YqfC BC_4306 ENOG4105KTH gatB Yqey BC_4308 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BC_4309 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BC_4315 ENOG4105CSA Coproporphyrinogen iii oxidase BC_4316 ENOG4105KVH Transcriptional regulator BC_4317 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BC_4319 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) BC_4321 ENOG4105TQK DNA polymerase iii, delta' subunit BC_4322 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BC_4323 ENOG4108UK2 deaminase BC_4324 ENOG4105KQC Competence protein BC_4326 ENOG4105DXX methyltransferase BC_4328 ENOG4108WF2 Metal Dependent Phosphohydrolase BC_4330 ENOG410812S Rna-binding protein BC_4332 ENOG4105CQW ribosome biogenesis GTPase YqeH BC_4333 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BC_4336 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BC_4340 ENOG4108TVJ Nitroreductase BC_4343 ENOG4105G6Z alkaline phosphatase BC_4344 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BC_4345 ENOG4108MUZ hydrolase BC_4351 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BC_4352 ENOG4105MIR Phenylalanine 4-monooxygenase BC_4354 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BC_4362 ENOG4105S6R Iron-hydroxamate transporter permease subunit BC_4363 ENOG4108HUF Transporter BC_4365 ENOG4108EKI Dehydrogenase BC_4366 ENOG4105C28 cystathionine BC_4372 ENOG4107XRG penicillin-binding protein BC_4374 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BC_4376 ENOG4105CFP Peptidase U32 BC_4377 ENOG4105XYU peptidase (U32 family) BC_4378 ENOG4108VQJ O-methyltransferase BC_4379 ENOG4105HHA aminodeoxychorismate lyase BC_4383 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BC_4385 ENOG4105C02 permease BC_4388 ENOG41060CR BC_4389 ENOG4105C7H Helicase, RecD TraA family BC_4391 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BC_4392 ENOG4105C3J Cysteine desulfurase BC_4394 ENOG4105D1H recombination factor protein RarA BC_4395 ENOG4108VCI transcription factor, rsfa family BC_4396 ENOG4105CUZ uba thif-type nad fad binding protein BC_4398 ENOG4105CUT histidyl-tRNA synthetase BC_4400 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BC_4401 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BC_4403 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BC_4404 ENOG41076HS cation diffusion facilitator family transporter BC_4405 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BC_4407 ENOG4105CKP Polysaccharide Biosynthesis Protein BC_4408 ENOG4108QG2 Membrane BC_4410 ENOG4105VIE preprotein translocase, subunit YajC BC_4412 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BC_4413 ENOG41061AI Protein of unknown function (DUF2905) BC_4416 ENOG4108HUF Transporter BC_4421 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BC_4422 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BC_4423 ENOG4108IYU L-aspartate oxidase BC_4426 ENOG4108RPX mosc domain containing protein BC_4427 ENOG4105CQC Prephenate dehydratase BC_4431 ENOG4105C19 ABC transporter BC_4432 ENOG4105EWM Histidine kinase BC_4434 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BC_4437 ENOG4105X36 (ribosomal) protein BC_4439 ENOG4105C03 ribonuclease BC_4442 ENOG4107QMS site-determining protein BC_4445 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BC_4446 ENOG4105DFF Rod shape-determining protein mreb BC_4456 ENOG4105DZR Type I site-specific deoxyribonuclease BC_4457 ENOG4105DZR Type I site-specific deoxyribonuclease BC_4462 ENOG4108Z03 MAF-like protein BC_4464 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BC_4465 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BC_4467 ENOG41068KH stage VI sporulation protein D BC_4469 ENOG4105D52 delta-aminolevulinic acid dehydratase BC_4473 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BC_4474 ENOG4105K56 Transcriptional regulator BC_4478 ENOG4108IUQ atp-dependent protease BC_4483 ENOG4108QCI YvbH-like oligomerisation region BC_4487 ENOG4105C4R Atp-dependent dna helicase BC_4492 ENOG4105M59 Phosphodiesterase, mj0936 family BC_4493 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BC_4495 ENOG4108XJQ germination protein BC_4497 ENOG4108PCX Major Facilitator BC_4499 ENOG4105KBX Transcriptional regulator, TetR family BC_4501 ENOG4105PFC Transcriptional regulator BC_4503 ENOG4105DZC cytosine deaminase BC_4504 ENOG41067S9 phage shock protein C, PspC BC_4505 ENOG4108JCI Transcriptional regulator BC_4507 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BC_4508 ENOG4108Z40 Transcriptional regulator BC_4509 ENOG4105RHA ABC transporter, permease BC_4510 ENOG4108IUX (ABC) transporter BC_4511 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BC_4512 ENOG4105ER2 Ompa motb domain protein BC_4513 ENOG4105E14 MotA TolQ exbB proton channel BC_4514 ENOG4108VXD carboxy-peptidase BC_4516 ENOG4105E33 succinate dehydrogenase BC_4518 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BC_4520 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BC_4521 ENOG4105K63 Thioredoxin BC_4523 ENOG4105BZJ Electron transfer flavoprotein BC_4524 ENOG41060WC Enoyl-CoA hydratase BC_4525 ENOG4107Z3H Transcriptional regulator, TetR family BC_4526 ENOG4105CEY Amp-dependent synthetase and ligase BC_4528 ENOG4105J76 Periplasmic binding protein BC_4539 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BC_4541 ENOG4105DR4 Methyltransferase BC_4543 ENOG4105KFN sortase, SrtB family BC_4544 ENOG4105E0A ABC, transporter BC_4547 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BC_4549 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BC_4551 ENOG4105FE9 pseudouridine synthase BC_4553 ENOG4105DCG PHP domain protein BC_4556 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BC_4559 ENOG4105C5S asparaginyl-tRNA synthetase BC_4560 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BC_4562 ENOG4108RWN rrna methyltransferase BC_4568 ENOG4105C0R drug resistance transporter emrb qaca subfamily BC_4569 ENOG4105CW7 secretion protein, HlyD family BC_4570 ENOG4108JGH Tetr family transcriptional regulator BC_4571 ENOG4105CN9 Peptidase m42 family protein BC_4575 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BC_4576 ENOG4105C22 threonyL-tRNA synthetase BC_4577 ENOG4108TDW sporulation protein YtxC BC_4582 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BC_4583 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BC_4584 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BC_4586 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BC_4587 ENOG4105C2M dna polymerase I BC_4588 ENOG4105BZU Histidine kinase BC_4589 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BC_4592 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BC_4593 ENOG4108HMX isocitrate dehydrogenase (NADP) BC_4594 ENOG4105BZN citrate synthase BC_4597 ENOG4108REF Sporulation integral membrane protein ytvi BC_4598 ENOG4105FS0 cytoplasmic membrane protein BC_4600 ENOG4105CTQ phosphohexokinase BC_4603 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BC_4604 ENOG4105C6K Malic enzyme BC_4605 ENOG4105C0B DNA polymerase III (alpha subunit) BC_4606 ENOG4105VV2 BC_4608 ENOG4105SFS phosphoesterase RecJ domain protein BC_4613 ENOG4105E8R UPF0173 metal-dependent hydrolase BC_4614 ENOG4105DC7 peptidase M24 BC_4620 ENOG4105Z7P Acetyltransferase (GNAT) family BC_4621 ENOG41082W1 Cupin 2, conserved barrel domain protein BC_4625 ENOG4107YZX Universal stress protein BC_4629 ENOG4105CH7 arginosuccinase BC_4633 ENOG4108JYZ YitT family BC_4637 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BC_4639 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BC_4640 ENOG4105KBJ sporulation protein ytfj BC_4643 ENOG4105EFZ amidohydrolase BC_4645 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BC_4647 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BC_4650 ENOG4105RQF LysR family Transcriptional regulator BC_4652 ENOG4105U5Y Transcriptional regulator BC_4654 ENOG4105C28 cystathionine BC_4657 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BC_4658 ENOG4108UW5 maltose o-acetyltransferase BC_4660 ENOG4105F1V Acetoin utilization protein BC_4661 ENOG4105W87 Cbs domain BC_4662 ENOG4105DGU Histone deacetylase BC_4665 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BC_4667 ENOG4107SNB ankyrin repeat protein YahD BC_4668 ENOG4105EP9 oxidoreductase BC_4672 ENOG4105ETE Transcriptional regulator (LacI family BC_4674 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BC_4678 ENOG4105C88 aminopeptidase BC_4687 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BC_4689 ENOG4108VDD TRNA binding domain protein BC_4695 ENOG4105C8F Beta-lactamase domain protein BC_4698 ENOG4108V15 phosphotransferase enzyme family BC_4702 ENOG4107QSE Dipeptidase BC_4703 ENOG4105YW5 deoR family transcriptional regulator BC_4706 ENOG4105CBX hi0933 family BC_4714 ENOG4108VJ1 Transcriptional regulator (CarD family BC_4715 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BC_4716 ENOG4105CSC Glucose uptake protein BC_4719 ENOG4108ZAF Molybdopterin BC_4720 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BC_4721 ENOG4105CVM Molybdenum cofactor synthesis domain protein BC_4723 ENOG4105D06 uba thif-type nad fad binding protein BC_4724 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BC_4728 ENOG41085GJ domain protein BC_4730 ENOG4105DWV Homoserine O-trans-acetylase BC_4732 ENOG4108B31 Spore germination protein BC_4737 ENOG4105C8T Leucyl-tRNA synthetase BC_4738 ENOG410605W Major Facilitator BC_4739 ENOG4107S91 Sodium hydrogen exchanger BC_4740 ENOG4105NCW Trka-c domain protein BC_4743 ENOG4105C19 ABC transporter BC_4746 ENOG4105N5T Radical SAM Protein BC_4748 ENOG4105CIG ABC transporter BC_4753 ENOG4105E8V Alpha Beta Hydrolase Fold protein BC_4754 ENOG4108Z0R Transferase BC_4755 ENOG4105YVM Phosphoesterase, PA-phosphatase related BC_4756 ENOG4105BZF Glycosyl transferase (Group 1 BC_4758 ENOG4105EPU Molybdenum cofactor synthesis domain protein BC_4760 ENOG4108MK9 spermidine N(1)-acetyltransferase BC_4770 ENOG4105BZU Histidine kinase BC_4771 ENOG4105BZU Histidine kinase BC_4774 ENOG4107S9D Alpha beta hydrolase BC_4775 ENOG4107T7U Sulfatase BC_4778 ENOG4105D2X ABC transporter substrate-binding protein BC_4780 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BC_4791 ENOG4108V2W Carbonate dehydratase BC_4792 ENOG4105C4M (Ubiquinol oxidase) subunit I BC_4793 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BC_4801 ENOG41087YS Phage shock protein A BC_4803 ENOG4105DQ6 Transposase BC_4809 ENOG4105BZU Histidine kinase BC_4810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BC_4815 ENOG4108UGV hypoxanthine phosphoribosyltransferase BC_4816 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BC_4824 ENOG4105C19 ABC transporter BC_4825 ENOG4105C19 ABC transporter BC_4828 ENOG4107ZTW SNARE associated Golgi BC_4829 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BC_4831 ENOG4105C19 ABC transporter BC_4832 ENOG41086D8 Transcriptional regulator BC_4834 ENOG41082BM Transcriptional regulator, arsr family BC_4841 ENOG4105C6Z Gluconate BC_4842 ENOG4105FDP GntR family transcriptional regulator BC_4846 ENOG41069H0 dihydroorotase EC 3.5.2.3 BC_4851 ENOG4105CEY Amp-dependent synthetase and ligase BC_4853 ENOG4108IPT Naphthoate synthase BC_4854 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BC_4855 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BC_4856 ENOG4105E4F Isochorismate synthase BC_4857 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BC_4859 ENOG4105VEQ Cold shock protein BC_4864 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BC_4866 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BC_4867 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BC_4869 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BC_4870 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BC_4889 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BC_4895 ENOG4105KT7 mgtC SapB transporter BC_4899 ENOG4105WG9 Conserved Protein BC_4901 ENOG4105CHM Aminotransferase BC_4902 ENOG4108ZB6 transcriptional regulator AsnC family BC_4903 ENOG4105C5I Dehydrogenase BC_4904 ENOG4108MUZ hydrolase BC_4906 ENOG4105C87 Aminotransferase class I and II BC_4909 ENOG4105Y38 Kinase-associated protein B BC_4911 ENOG4107R3E Citrate transporter BC_4915 ENOG4105KA0 thioesterase Superfamily protein BC_4918 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BC_4921 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BC_4922 ENOG41069ER domain protein BC_4925 ENOG4105CEP NADH dehydrogenase BC_4931 ENOG4105EWC Purine nucleoside phosphorylase BC_4933 ENOG4108VQJ O-methyltransferase BC_4935 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BC_4936 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BC_4940 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BC_4941 ENOG4105C4B ABC transporter, permease BC_4942 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BC_4952 ENOG41083MR nifu domain-containing protein BC_4955 ENOG4108W5N phosphatidylglycerophosphatase a BC_4958 ENOG4105DYS nad(p)h dehydrogenase (quinone) BC_4959 ENOG4105D4U had-superfamily hydrolase, subfamily iia BC_4962 ENOG4105CBT Fructose-1,6-bisphosphatase BC_4966 ENOG4105MMD transcriptional regulator BC_4967 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BC_4968 ENOG4107TXC Transcriptional regulator BC_4969 ENOG41090T1 Membrane BC_4973 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BC_4974 ENOG4105FAA peptidase M23 BC_4975 ENOG4108YTE sporulation protein YunB BC_4976 ENOG4105KZD Domain of unknown function (DUF1805) BC_4977 ENOG4107R8B 5'-nucleotidase BC_4979 ENOG4105DIW FeS assembly protein SUFB BC_4980 ENOG4108UNV SUF system FeS assembly protein, NifU family BC_4981 ENOG4105C9B Cysteine desulfurase BC_4982 ENOG4105JRK feS assembly protein SufD BC_4983 ENOG4105C3K feS assembly ATPase SufC BC_4984 ENOG4105D01 (LipO)protein BC_4985 ENOG4105D01 (LipO)protein BC_4986 ENOG4108UMI ABC transporter, permease BC_4987 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BC_4992 ENOG41080E8 Transcriptional regulator, Spx MgsR family BC_4996 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BC_5001 ENOG4108W8B Beta-lactamase domain protein BC_5002 ENOG4105C1G acyl-Coa dehydrogenase BC_5003 ENOG4105CHU acetyl-coa acetyltransferase BC_5005 ENOG4105DZ1 carboxypeptidase BC_5009 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BC_5012 ENOG4108SUT Major Facilitator Superfamily BC_5013 ENOG4107R7I amino acid BC_5016 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BC_5018 ENOG4107AYK membrAne BC_5025 ENOG4107ZTW SNARE associated Golgi BC_5027 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BC_5028 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BC_5029 ENOG4105BZU Histidine kinase BC_5031 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BC_5034 ENOG4105C8Q Methyl-accepting chemotaxis BC_5035 ENOG4105VG1 fes assembly suf system protein BC_5036 ENOG4105D4Y metalloprotease BC_5040 ENOG4107T5V SNARE associated Golgi BC_5041 ENOG4107S91 Sodium hydrogen exchanger BC_5042 ENOG4105NCW Trka-c domain protein BC_5044 ENOG4108RMU ferritin dps family protein BC_5046 ENOG4108URH decarboxylase BC_5048 ENOG41090A1 ferritin BC_5050 ENOG4105D9N nucleoside BC_5054 ENOG4108RYK Nad-dependent epimerase dehydratase BC_5057 ENOG4105CV8 reductase BC_5058 ENOG4105F27 Major Facilitator BC_5059 ENOG4105KVH Transcriptional regulator BC_5062 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BC_5063 ENOG4105D4A Cell wall formation (By similarity) BC_5065 ENOG4105C8Q Methyl-accepting chemotaxis BC_5067 ENOG4105WMR Protein CrcB homolog BC_5068 ENOG4105WMR Protein CrcB homolog BC_5072 ENOG4105C5H ABC transporter BC_5073 ENOG4108MK9 spermidine N(1)-acetyltransferase BC_5075 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BC_5076 ENOG4105EMU Dehydrogenase BC_5078 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BC_5079 ENOG4108R85 Short chain dehydrogenase BC_5103 ENOG4108IPW abc transporter atp-binding protein BC_5104 ENOG4105CM4 permease protein BC_5115 ENOG4108BUD transposase BC_5127 ENOG4108BUD transposase BC_5129 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BC_5131 ENOG4105XZU Preprotein translocase, subunit SecG BC_5132 ENOG41067MG lrgb family BC_5136 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BC_5143 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BC_5147 ENOG41090VF Stage v sporulation protein ac BC_5148 ENOG4105CZ3 stage V sporulation protein ad BC_5151 ENOG4108QY0 Membrane BC_5152 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BC_5153 ENOG4105KRI phosphocarrier protein (HPr BC_5155 ENOG4105CHW UPF0052 protein BC_5156 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BC_5157 ENOG4108Z4K mutator MutT protein BC_5159 ENOG4105C3M thioredoxin reductase BC_5161 ENOG4108S4C acetyltransferase BC_5163 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BC_5165 ENOG41086DT Membrane protein of unknown function BC_5167 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BC_5171 ENOG4107TXC Transcriptional regulator BC_5174 ENOG4105HMI Membrane BC_5175 ENOG4105DUM transcriptional regulator, lysR family BC_5177 ENOG4108WS4 fmn reductase BC_5179 ENOG4105IYK transposase BC_5180 ENOG4105DQ6 Transposase BC_5182 ENOG4105BZ1 (ABC) transporter BC_5184 ENOG4105CN1 protease BC_5185 ENOG4105CRP Part of the ABC transporter FtsEX involved in BC_5186 ENOG4105CAK Cell division ATP-binding protein ftsE BC_5188 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BC_5189 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BC_5190 ENOG4105MS2 ribosomal subunit Interface protein BC_5191 ENOG4105VEQ Cold shock protein BC_5192 ENOG41081UC Inherit from COG: Competence protein BC_5197 ENOG4105KVH Transcriptional regulator BC_5199 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BC_5200 ENOG4108KGH TRANSCRIPTIONal BC_5201 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BC_5202 ENOG4105C6Y Udp-glucose 6-dehydrogenase BC_5203 ENOG4105ESV Glycosyl transferase, family 4 BC_5205 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BC_5209 ENOG4105F8D glycoside hydrolase family 4 BC_5210 ENOG4105VCP PTS System BC_5211 ENOG4105CK1 PTS System BC_5213 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BC_5214 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BC_5215 ENOG4105VCP PTS System BC_5217 ENOG4105VZJ PTS System BC_5221 ENOG4105ECB domain protein BC_5222 ENOG4107RSM transcriptional regulator BC_5227 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BC_5228 ENOG4105DAA L-lactate BC_5230 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BC_5232 ENOG4105E0M Sulfatase BC_5237 ENOG4107R8N Glycosyl transferase, family 2 BC_5238 ENOG4105C94 Transporter BC_5239 ENOG41069ER domain protein BC_5244 ENOG4105KBK Zinc finger, swim domain protein BC_5245 ENOG4105C0D helicase BC_5251 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BC_5253 ENOG4107RBB ABC transporter, permease BC_5254 ENOG4105C19 ABC transporter BC_5258 ENOG4105CXY transporter BC_5261 ENOG4105BZU Histidine kinase BC_5262 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BC_5263 ENOG4105CMR udp-glucose 4-epimerase BC_5265 ENOG4108KGH TRANSCRIPTIONal BC_5269 ENOG4107T8Q Glycosyl transferase (Group 1 BC_5271 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) BC_5272 ENOG4105CPF Cell wall formation (By similarity) BC_5273 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BC_5275 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BC_5276 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BC_5277 ENOG4107YJ4 chain length determinant protein BC_5278 ENOG4105HTX biosynthesis protein BC_5279 ENOG4107YJ4 chain length determinant protein BC_5282 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BC_5283 ENOG4105FRN stage II sporulation protein BC_5286 ENOG4105DY9 regulatoR BC_5290 ENOG4106778 Protein of unknown function (DUF1146) BC_5291 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BC_5292 ENOG4105C8S subunit m BC_5293 ENOG4105D65 subunit l BC_5298 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BC_5299 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BC_5301 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BC_5302 ENOG4105BZU Histidine kinase BC_5312 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BC_5313 ENOG41062M3 atp synthase BC_5316 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BC_5317 ENOG4108UIC UPF0340 protein BC_5318 ENOG4108YZG isomerase BC_5321 ENOG4108VGI doxx family BC_5322 ENOG4107XC4 flavin reductase domain protein, FMN-binding BC_5325 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BC_5327 ENOG4108ZXQ stage ii sporulation protein r BC_5328 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BC_5329 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BC_5330 ENOG4107104 thymidine kinase BC_5332 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BC_5333 ENOG4105CBT Fructose-1,6-bisphosphatase BC_5334 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BC_5338 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BC_5341 ENOG4105C1G acyl-Coa dehydrogenase BC_5342 ENOG4105C1G acyl-Coa dehydrogenase BC_5343 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BC_5345 ENOG4105DF6 Fe-S oxidoreductase BC_5351 ENOG4105D4Y metalloprotease BC_5353 ENOG4105BZU Histidine kinase BC_5354 ENOG4105KCT ABC transporter BC_5355 ENOG4108M15 ABC transporter BC_5356 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BC_5359 ENOG4105IIU Aminopeptidase BC_5363 ENOG4105DU6 RNA polymerase BC_5365 ENOG410684U Domain of unknown function (DUF1934) BC_5370 ENOG4105CYW agmatinase BC_5371 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BC_5372 ENOG4105DXB Major Facilitator superfamily BC_5373 ENOG4107SWG transcriptional regulator MERR family BC_5374 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BC_5375 ENOG4105BZ4 penicillin-binding protein BC_5376 ENOG4108XFG YwhD family BC_5377 ENOG4108Z4T Peptidase M50 BC_5378 ENOG41069HH 4-oxalocrotonate tautomerase BC_5379 ENOG4105DCI Phosphohydrolase BC_5380 ENOG4108MES Periplasmic binding protein BC_5381 ENOG4105E0A ABC, transporter BC_5382 ENOG4105EHG Permease protein BC_5383 ENOG4105DQ5 transport system permease protein BC_5385 ENOG4108VCI transcription factor, rsfa family BC_5386 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BC_5387 ENOG4108IJ2 phosphate acetyltransferase BC_5388 ENOG4107UEZ chlorite dismutase BC_5390 ENOG4108VKI Cell wall hydrolase BC_5394 ENOG4107SVH Potassium channel protein BC_5396 ENOG410667J hydrolase BC_5397 ENOG4105VCH membrane BC_5399 ENOG4108TU7 Inherit from COG: (ABC) transporter BC_5400 ENOG4105CJ1 ABC, transporter BC_5401 ENOG41090WU lipolytic protein G-D-S-L family BC_5404 ENOG4105D6E homoserine dehydrogenase BC_5405 ENOG4105CVG Homoserine O-transsuccinylase BC_5409 ENOG4108Y4K DNA-binding transcriptional activator BC_5411 ENOG4105WH1 Two component transcriptional regulator luxr family BC_5412 ENOG4105BZU Histidine kinase BC_5413 ENOG4105DWF phosphomethylpyrimidine kinase BC_5414 ENOG4105BZU Histidine kinase BC_5415 ENOG4105VCD cytoplasmic protein BC_5416 ENOG4105D22 carbon starvation protein BC_5417 ENOG4105DY9 regulatoR BC_5418 ENOG41079KZ Major Facilitator Superfamily BC_5420 ENOG4105CG5 Glycosyl transferase (Group 1 BC_5423 ENOG4105EN6 Membrane BC_5424 ENOG4106YBV Methyl-accepting chemotaxis BC_5426 ENOG4108S4H thioesterase Superfamily protein BC_5427 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BC_5429 ENOG4105K64 Glycosyl transferase, family 2 BC_5432 ENOG4105CKK Glycosyl transferase, family 2 BC_5433 ENOG4105C5H ABC transporter BC_5434 ENOG41067SE Tetr family transcriptional regulator BC_5436 ENOG4105E0X reductase BC_5437 ENOG4106F5Q Membrane BC_5439 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) BC_5440 ENOG4108NEV two component transcriptional regulator, LytTR family BC_5442 ENOG4107RGD Major Facilitator superfamily BC_5445 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BC_5447 ENOG4105IW1 AmiS UreI transporter BC_5448 ENOG4105CMR udp-glucose 4-epimerase BC_5449 ENOG4108UT2 hemolysin iii BC_5451 ENOG4105C1J atp-dependent rna helicase BC_5452 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) BC_5453 ENOG4105DPN Oligoendopeptidase f BC_5455 ENOG4105BZU Histidine kinase BC_5456 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BC_5458 ENOG4105C0H protease BC_5462 ENOG4105BZU Histidine kinase BC_5463 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BC_5468 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BC_5472 ENOG4105BZR domain protein BC_5473 ENOG4108XMW Membrane BC_5475 ENOG4108UUM single-stranded DNA-binding protein BC_5477 ENOG4105C3G gtp-binding protein BC_5478 ENOG4105VDK protein, conserved in bacteria BC_5479 ENOG4105D8X mechanosensitive ion channel BC_5480 ENOG4108ZDA Sporulation protein YyaC BC_5481 ENOG4105FA0 parb-like partition protein BC_5482 ENOG4107QJE Chromosome Partitioning Protein BC_5485 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BC_5486 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BC_5488 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BC_5489 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BC_p0006 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)