locus-tag class description BF35_1003 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BF35_1004 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF35_1005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF35_1006 ENOG4105DUM transcriptional regulator, lysR family BF35_1012 ENOG4108U4N (sortase) family BF35_1019 ENOG4105KAC Antibiotic biosynthesis monooxygenase BF35_1025 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF35_1026 ENOG4105KTQ flagellar basal-body rod protein BF35_1027 ENOG4105FZW flagellar biosynthesis regulator FlhF BF35_1028 ENOG4105D7B Flagellar biosynthesis protein flha BF35_1029 ENOG4105D00 flagellar biosynthetic protein flhB BF35_1031 ENOG4105VS8 Flagellar biosynthetic protein fliq BF35_1032 ENOG4105CN7 Flagellar biosynthetic protein FliP BF35_1034 ENOG4105DD5 Flagellar motor switch protein BF35_1035 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF35_1037 ENOG4105E4C Lytic transglycosylase catalytic BF35_1038 ENOG4105I03 Flagellin BF35_1041 ENOG4107R88 Chemotaxis protein (CheV) BF35_1044 ENOG4105BZE flagellar hook protein, FlgE BF35_1050 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF35_1051 ENOG4107U2N Flagellar M-ring protein BF35_1052 ENOG41075Z6 flagellar hook-basal body complex protein fliE BF35_1053 ENOG4108ZC9 flagellar basal-body rod protein flgc BF35_1054 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BF35_1057 ENOG410804A Flagellar hook-associated 2 domain-containing protein BF35_1058 ENOG4105DTJ flagellar hook-associated protein BF35_1059 ENOG4105E1Q flagellar hook-associated protein BF35_1063 ENOG4105BZU Histidine kinase BF35_1066 ENOG4105DD5 Flagellar motor switch protein BF35_1067 ENOG4105CBS Chea signal transduction histidine kinase BF35_1068 ENOG4107YTP response regulator receiver protein BF35_1069 ENOG4105ER2 Ompa motb domain protein BF35_1070 ENOG4107R0U MotA TolQ exbB proton channel BF35_1072 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF35_108 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF35_1083 ENOG41080C8 DUF218 domain BF35_1084 ENOG4105H67 Protein of unknown function (DUF421) BF35_1086 ENOG4108Z5V transcriptional regulator, merr family BF35_1087 ENOG4105CN5 Metallo-Beta-Lactamase BF35_1088 ENOG4107RWR Sodium hydrogen exchanger BF35_1090 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF35_1103 ENOG41081VK Ribonuclease BF35_1107 ENOG4108SZE gCN5-related N-acetyltransferase BF35_1110 ENOG4105CPK Glycosyl transferase (Group 1 BF35_1117 ENOG4105EXC Acyl-transferase BF35_1122 ENOG4106032 Glutathionylspermidine synthase BF35_1125 ENOG4105KHC sulfurtransferase BF35_1127 ENOG4108W0I acetyltransferase BF35_1129 ENOG410890F Dynamin family BF35_1131 ENOG4105DHF Membrane BF35_1132 ENOG4105C2W permease BF35_1133 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BF35_1134 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF35_1136 ENOG4105CTD carboxy-peptidase BF35_1137 ENOG4105DVT helicase BF35_1139 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BF35_1152 ENOG4105CSM endonuclease III BF35_1156 ENOG4105YAC BF35_1157 ENOG4105DVT helicase BF35_1164 ENOG4105CPK Glycosyl transferase (Group 1 BF35_1165 ENOG4105FJR Lmbe family BF35_1168 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BF35_1169 ENOG4108JYZ YitT family BF35_1176 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BF35_1177 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BF35_1180 ENOG41068YB TPR repeat-containing protein BF35_1185 ENOG4105EAH synthase BF35_1187 ENOG4105XXQ heptaprenyl diphosphate synthase component I BF35_1190 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BF35_1196 ENOG41065D1 BF35_1197 ENOG4105S2F BF35_1204 ENOG4107RB3 L-asparaginase BF35_1205 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BF35_1209 ENOG4108S6Z Negative regulator of genetic competence BF35_121 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF35_1210 ENOG4107X2D transcriptional regulator, merr family BF35_1211 ENOG4107RGJ metallophosphoesterase BF35_1213 ENOG4105I7S Abortive infection protein BF35_1214 ENOG4105C9U ATP-dependent DNA helicase RecQ BF35_1217 ENOG4108SAX Membrane BF35_1219 ENOG41063SB peptidase BF35_1220 ENOG4108WBT adenosyltransferase BF35_1221 ENOG4105BZU Histidine kinase BF35_1222 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF35_1223 ENOG4105CRE cytochrome C BF35_1224 ENOG4107TWT Cytochrome c biogenesis protein BF35_1226 ENOG4105FE9 pseudouridine synthase BF35_1228 ENOG4108JIC nucleoside recognition domain protein BF35_1229 ENOG4105DZ1 carboxypeptidase BF35_1230 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF35_1235 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BF35_1236 ENOG4105BZU Histidine kinase BF35_1239 ENOG4105I3N Conserved Protein BF35_124 ENOG4105CAR Terminase, large subunit BF35_1240 ENOG4105BZU Histidine kinase BF35_1243 ENOG4105BZ4 penicillin-binding protein BF35_1244 ENOG4107GRR phosphate transport regulator BF35_1245 ENOG4105CJ3 phosphate transporter BF35_1254 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF35_1258 ENOG4105WH1 Two component transcriptional regulator luxr family BF35_1259 ENOG4105ENE Histidine kinase BF35_1263 ENOG4105DFD Na H antiporter BF35_1267 ENOG4105C8J )-transporter BF35_1268 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF35_1269 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF35_1270 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF35_1272 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BF35_1273 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BF35_1277 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BF35_1279 ENOG4105E0M Sulfatase BF35_1280 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF35_1283 ENOG4107RVV histidinol phosphate phosphatase, hisj family BF35_1298 ENOG4108ZP8 Acetolactate synthase small subunit BF35_1299 ENOG4105C7K acetolactate synthase BF35_13 ENOG4105U0R haloacid dehalogenase-like hydrolase BF35_1300 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF35_1304 ENOG4105KBJ sporulation protein ytfj BF35_1305 ENOG41063Y9 BF35_1306 ENOG4105CZN Potassium uptake protein BF35_1313 ENOG4107QMU Mate efflux family protein BF35_1320 ENOG4105NQC Flavodoxin BF35_1325 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF35_1327 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF35_1328 ENOG4105EA8 2-Nitropropane dioxygenase BF35_1329 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF35_1337 ENOG4105CJ1 ABC, transporter BF35_1339 ENOG4105CZV ABC transporter BF35_134 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BF35_1340 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF35_1341 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF35_1342 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF35_1343 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF35_1344 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BF35_1352 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BF35_1353 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BF35_1355 ENOG4105BZU Histidine kinase BF35_1357 ENOG4106DF1 BF35_1359 ENOG41090MY MarR family Transcriptional regulator BF35_1360 ENOG4105BZU Histidine kinase BF35_1362 ENOG4105PXI polysaccharide deacetylase BF35_1364 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF35_1367 ENOG4105E98 transcriptional regulator DeoR family BF35_1371 ENOG4107RCV ABC transporter, permease BF35_1372 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF35_1373 ENOG4105C4Y ABC transporter BF35_1379 ENOG4105CHR reductase BF35_1383 ENOG4108Z7G MaoC domain protein dehydratase BF35_1384 ENOG410681C small acid-soluble spore protein BF35_1385 ENOG4105CZN Potassium uptake protein BF35_1386 ENOG4107TS3 membrane protein, TerC BF35_1387 ENOG4108QTI )-transporter BF35_1389 ENOG4106A3R peptidase BF35_1393 ENOG4105JXH GntR family transcriptional regulator BF35_1394 ENOG4105JXH GntR family transcriptional regulator BF35_1395 ENOG4105BZU Histidine kinase BF35_1396 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF35_1399 ENOG4105CQB FAD linked oxidase domain protein BF35_1400 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF35_1401 ENOG4105K4I Scp-like extracellular BF35_1403 ENOG4108YBP pseudouridine synthase BF35_1405 ENOG4105EYF MMPL domain protein BF35_1407 ENOG4107RUE extracellular solute-binding protein family 1 BF35_1408 ENOG4105D38 putrescine abc transporter BF35_1409 ENOG4105F38 ABC transporter, permease BF35_1411 ENOG4105C26 Dehydrogenase BF35_1419 ENOG4105VFR signal peptidase BF35_1420 ENOG4105DZ1 carboxypeptidase BF35_1422 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BF35_1436 ENOG4105VZ8 Transcriptional regulator BF35_1438 ENOG4105C7S Dehydrogenase BF35_1454 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BF35_1458 ENOG4105DDQ anthranilate synthase BF35_1459 ENOG4105CRQ synthase (Component I) BF35_1460 ENOG4105CK7 Sodium proline symporter BF35_1475 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BF35_1477 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BF35_1478 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BF35_148 ENOG4105KRN Transcriptional regulator, abrb family BF35_1482 ENOG4107TVC Glycosyl transferase, family 2 BF35_1486 ENOG4105K64 Glycosyl transferase, family 2 BF35_1490 ENOG4105EMS pseudouridine synthase BF35_1493 ENOG4106EFP UPF0738 protein BF35_1494 ENOG4105MIX Adenylate cyclase BF35_1495 ENOG4108Z18 K06886 hemoglobin BF35_1498 ENOG4105DPN Oligoendopeptidase f BF35_150 ENOG4106CVF DNA replication protein BF35_1500 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF35_1502 ENOG4108ZCF integral membrane protein BF35_1506 ENOG4105UQX Mate efflux family protein BF35_1507 ENOG4108JQ7 (ABC) transporter BF35_1509 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF35_1510 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF35_1513 ENOG4105C31 Tryptophanyl-tRNA synthetase BF35_1516 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF35_1517 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF35_1524 ENOG4108KP7 hydrolase BF35_1526 ENOG41073B9 BF35_1527 ENOG4107AYK membrAne BF35_1529 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF35_1530 ENOG4105QNR S1 RNA binding domain protein BF35_1531 ENOG4108VPT UPF0234 protein BF35_1534 ENOG4105BZU Histidine kinase BF35_1535 ENOG4105CH6 catalase BF35_1537 ENOG4105CAQ asparagine synthetase BF35_1542 ENOG4105ERH Fumarylacetoacetate hydrolase BF35_1560 ENOG4105XVF Competence transcription factor BF35_1563 ENOG4105VEQ Cold shock protein BF35_1566 ENOG4107QP3 malate synthase g BF35_1567 ENOG4105ZU5 s-layer protein BF35_1571 ENOG4105C8Q Methyl-accepting chemotaxis BF35_1572 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BF35_1577 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF35_1580 ENOG41086D8 Transcriptional regulator BF35_1581 ENOG4108AEY RNA polymerase sigma factor BF35_1583 ENOG4107TVP HD domain protein BF35_1584 ENOG4107RN3 metallophosphoesterase BF35_1585 ENOG4105ENX hydrolase BF35_1586 ENOG4105ST3 Transcriptional regulator BF35_1590 ENOG4105CNA YD repeat protein BF35_1593 ENOG4105CEY Amp-dependent synthetase and ligase BF35_1595 ENOG4105DF9 Lipoate-protein, ligase BF35_1596 ENOG4108RQ5 Beta-lactamase domain-containing protein BF35_1597 ENOG4106AXD BF35_1599 ENOG4105D29 Helix-turn-helix type 11 domain protein BF35_160 ENOG4105VTR Integrase BF35_1604 ENOG4105ECB domain protein BF35_1610 ENOG4105C1Q protoporphyrinogen oxidase BF35_1611 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BF35_1613 ENOG4105BZ4 penicillin-binding protein BF35_1614 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BF35_1615 ENOG4105CKV Membrane BF35_1616 ENOG410905X membrane-flanked domain protein BF35_1623 ENOG4105CKV Membrane BF35_1624 ENOG410905X membrane-flanked domain protein BF35_1631 ENOG4105K59 histidine triad (HIT) protein BF35_1636 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF35_1637 ENOG4105EEM helicase BF35_164 ENOG4105ETU transcriptional activator (TenA BF35_1641 ENOG4105EMN RNA polymerase sigma factor BF35_1646 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BF35_1649 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF35_1653 ENOG4108MUZ hydrolase BF35_1664 ENOG4105ED2 Beta-lactamase BF35_1666 ENOG4106D4I domain protein BF35_1667 ENOG4107VRP DNA repair exonuclease BF35_167 ENOG4105D6E homoserine dehydrogenase BF35_1672 ENOG4108VB1 regulatoR BF35_1673 ENOG4105ENE Histidine kinase BF35_1678 ENOG4105K8R UPF0145 protein BF35_1683 ENOG4105BZU Histidine kinase BF35_1684 ENOG4105BZU Histidine kinase BF35_1685 ENOG4108MJI response regulator BF35_1687 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF35_1689 ENOG4105WN5 stage II sporulation protein BF35_1702 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BF35_1707 ENOG410847I Transcriptional regulator, BadM Rrf2 family BF35_1709 ENOG4105CMT Dihydroxyacetone kinase BF35_1711 ENOG4105CMT Dihydroxyacetone kinase BF35_1715 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF35_1728 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF35_1734 ENOG4105CDU Replicative dna helicase BF35_1741 ENOG4105CFI type iii restriction protein res subunit BF35_1744 ENOG4105M6F mutator MutT protein BF35_1746 ENOG4108MRH transcriptional regulatory protein BF35_1748 ENOG4105CSH Transporter BF35_1755 ENOG4105CTU Proline racemase BF35_1759 ENOG4105DER m42 family BF35_1763 ENOG4105CGU Enoyl-CoA hydratase BF35_1765 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF35_1767 ENOG4106AKK s-layer domain-containing protein BF35_1773 ENOG4105CHH sulfate transporter BF35_1778 ENOG4105D4P Coproporphyrinogen iii oxidase BF35_1779 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF35_1783 ENOG4107FQX Alpha-acetolactate decarboxylase BF35_1790 ENOG410839P BF35_1793 ENOG4105CDA abc transporter atp-binding protein BF35_1794 ENOG4105DRP amino acid AbC transporter BF35_1796 ENOG4105BZ1 (ABC) transporter BF35_1797 ENOG4105BZ1 (ABC) transporter BF35_1798 ENOG4105C26 Dehydrogenase BF35_18 ENOG4107VFR oxidoreductase BF35_1800 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BF35_1801 ENOG4105D5Q Arginine ornithine antiporter BF35_1803 ENOG4105CH6 catalase BF35_1804 ENOG4107RKG DJ-1/PfpI family BF35_1806 ENOG4105E5W Transporter BF35_1807 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF35_1814 ENOG4105KPY Small multidrug resistance protein BF35_1815 ENOG4105KPY Small multidrug resistance protein BF35_1817 ENOG4108YXU transcriptional regulator AsnC family BF35_182 ENOG4105DK7 lysyl-tRNA synthetase BF35_1825 ENOG4106KNT transcriptional regulator BF35_1827 ENOG4107RWR Sodium hydrogen exchanger BF35_1828 ENOG4105CUB amino acid BF35_1835 ENOG4107T5V SNARE associated Golgi BF35_184 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BF35_1842 ENOG4105WEF catalase BF35_1848 ENOG4105C19 ABC transporter BF35_1849 ENOG4107RBB ABC transporter, permease BF35_1853 ENOG4105YVS arsR family transcriptional regulator BF35_1855 ENOG4107SET aldo keto reductase BF35_1856 ENOG4105F27 Major Facilitator BF35_1857 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF35_1858 ENOG4107XZQ multidrug resistance protein BF35_186 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF35_1860 ENOG4105C1B dTDP-glucose 4-6-dehydratase BF35_1864 ENOG41069ER domain protein BF35_1868 ENOG4105VZJ PTS System BF35_1869 ENOG4105VCP PTS System BF35_1870 ENOG4105EMD TRANSCRIPTIONal BF35_1875 ENOG4108KGH TRANSCRIPTIONal BF35_1877 ENOG41087NI Sulfite exporter TauE/SafE BF35_1878 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BF35_188 ENOG410900G Protein of unknown function (DUF421) BF35_1880 ENOG4105VFE sira family BF35_1882 ENOG4105VFE sira family BF35_1883 ENOG4107TPS domain protein BF35_1884 ENOG4105VFE sira family BF35_1885 ENOG4105XTG Pfam:DUF156 BF35_1886 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BF35_1891 ENOG4105ED1 spovr family BF35_1892 ENOG4107Y03 Nitroreductase BF35_1896 ENOG4108B31 Spore germination protein BF35_1903 ENOG4105C5Y PTS System BF35_1907 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF35_1909 ENOG4105C7N Xanthine uracil vitamin C permease BF35_1912 ENOG4108INS Transcriptional regulator BF35_192 ENOG4105EFA 4-hydroxyphenylacetate BF35_1921 ENOG4105DWF phosphomethylpyrimidine kinase BF35_1922 ENOG4105D06 uba thif-type nad fad binding protein BF35_1925 ENOG41080HI glycine oxidase BF35_1926 ENOG4108VEU Thiamine monophosphate synthase BF35_1928 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF35_1930 ENOG4105ETU transcriptional activator (TenA BF35_1935 ENOG41080XQ Signal transduction protein with cbs domains BF35_1961 ENOG4105E2Z phosphate ABC transporter (Permease BF35_1962 ENOG4105C8U phosphate abc transporter BF35_1963 ENOG4105CVA phosphate BF35_1964 ENOG4105CE1 Ferrous iron transport protein b BF35_1965 ENOG4105CE1 Ferrous iron transport protein b BF35_1966 ENOG4105CE1 Ferrous iron transport protein b BF35_1967 ENOG4108NHD germination protein BF35_1970 ENOG4105E1V na solute symporter BF35_1975 ENOG4105E2S oxidase) subunit II BF35_1976 ENOG4105BZ9 Cytochrome C oxidase, subunit I BF35_1980 ENOG4105MA6 gCN5-related N-acetyltransferase BF35_1983 ENOG4105C7N Xanthine uracil vitamin C permease BF35_1984 ENOG4105C85 amino acid BF35_1988 ENOG4105DUX Transporter BF35_1990 ENOG4107D63 BF35_1991 ENOG4105VZ8 Transcriptional regulator BF35_1992 ENOG41069ER domain protein BF35_1993 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF35_1994 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF35_2005 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF35_2006 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BF35_2007 ENOG4105CNN ABC, transporter BF35_2008 ENOG4105C2J ABC transporter BF35_201 ENOG41089UC methyltransferase, type 11 BF35_2010 ENOG4108RVA ribokinase BF35_2011 ENOG4105ETE Transcriptional regulator (LacI family BF35_2012 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF35_2013 ENOG41067TZ transcriptional regulator, MarR family BF35_2014 ENOG4105CXY transporter BF35_2016 ENOG4108JQ7 (ABC) transporter BF35_2017 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF35_202 ENOG4105KVH Transcriptional regulator BF35_2021 ENOG41068KF Universal stress protein BF35_2022 ENOG4105CHH sulfate transporter BF35_2025 ENOG4105BZU Histidine kinase BF35_2026 ENOG4105NAE bifunctional deaminase-reductase domain protein BF35_2027 ENOG4105D29 Helix-turn-helix type 11 domain protein BF35_2029 ENOG4105GFR rna polymerase sigma factor BF35_203 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr BF35_2032 ENOG4108IQI permease BF35_2033 ENOG4105DRP amino acid AbC transporter BF35_2034 ENOG4105EAD ABC transporter BF35_2035 ENOG4105CT1 (ABC) transporter BF35_2036 ENOG4105CDA abc transporter atp-binding protein BF35_2037 ENOG4105BZG amino acid carrier protein BF35_2038 ENOG4105CRN Aminoglycoside phosphotransferase BF35_2040 ENOG4105E1K spore germination protein BF35_2044 ENOG4105CG3 alpha amylase, catalytic region BF35_2045 ENOG4105C5Y PTS System BF35_2046 ENOG4107414 GntR family transcriptional regulator BF35_2047 ENOG4105D5Q Arginine ornithine antiporter BF35_2048 ENOG4105BZU Histidine kinase BF35_205 ENOG4107Y80 Major Facilitator superfamily BF35_2051 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF35_2052 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BF35_2056 ENOG4105EXW epimerase dehydratase BF35_2058 ENOG4105DMQ Methyltransferase BF35_2059 ENOG4105E0A ABC, transporter BF35_2060 ENOG4108IHU transport system permease protein BF35_2061 ENOG4105DQ5 transport system permease protein BF35_2062 ENOG4108MES Periplasmic binding protein BF35_2063 ENOG4105DUX Transporter BF35_2066 ENOG4105DAA L-lactate BF35_2067 ENOG4108IJ0 Aspartate ammonia-lyase BF35_2068 ENOG4105C37 (CBS) domain BF35_2069 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BF35_207 ENOG4105FQP Beta-lactamase BF35_2070 ENOG4105D9N nucleoside BF35_2071 ENOG4108KGH TRANSCRIPTIONal BF35_2072 ENOG41073R8 VanW family BF35_2079 ENOG4105DAP Nicotinate phosphoribosyltransferase BF35_2080 ENOG4105C59 p-type ATPase BF35_2082 ENOG4105CUB amino acid BF35_2086 ENOG4108JB9 formate dehydrogenase BF35_2087 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF35_2088 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF35_2090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF35_2091 ENOG4105BZU Histidine kinase BF35_2093 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF35_2094 ENOG4108UZ3 Transporter BF35_2096 ENOG4105C6K Malic enzyme BF35_2098 ENOG4108MRH transcriptional regulatory protein BF35_210 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF35_2103 ENOG4105US7 Histidine kinase BF35_2104 ENOG4108STX response regulator BF35_2109 ENOG4105D4T Citrate transporter BF35_2110 ENOG4108V9W transcriptional regulatory protein BF35_2111 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BF35_2114 ENOG4105DZ6 Band 7 protein BF35_2117 ENOG4105C94 Transporter BF35_2121 ENOG4105CYN Serine protein kinase BF35_2123 ENOG4105BZU Histidine kinase BF35_2124 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BF35_2126 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BF35_2130 ENOG4107ZQN disulfide bond BF35_2131 ENOG4108JQC penicillin-binding protein 1A BF35_2155 ENOG4105G5W regulator Fur family BF35_2156 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF35_2160 ENOG4108IUW ABC transporter BF35_2162 ENOG4105CBC glutamate synthase BF35_2163 ENOG4107NBY Membrane BF35_2164 ENOG4105BZ1 (ABC) transporter BF35_2168 ENOG4106BXE BF35_2169 ENOG4105CEN a g-specific adenine glycosylase BF35_217 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF35_2170 ENOG41067AE Membrane-bound metal-dependent hydrolase BF35_2176 ENOG4105ECP epimerase BF35_2177 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BF35_2181 ENOG4105F1A Pyruvate formate-lyase BF35_2184 ENOG4105C3I Nad-dependent epimerase dehydratase BF35_2185 ENOG4107QQG Dehydrogenase BF35_2186 ENOG4105CKK Glycosyl transferase, family 2 BF35_219 ENOG4105T9C HD domain BF35_2190 ENOG4108A04 Beta-lactamase BF35_2192 ENOG4105CSV Glutaminase BF35_2198 ENOG4108IQI permease BF35_2200 ENOG4108JUB Transcriptional regulator BF35_2211 ENOG4105UPD Calcium Proton BF35_2212 ENOG410606W general stress protein BF35_2215 ENOG4107ZTW SNARE associated Golgi BF35_2219 ENOG4108IPJ Membrane BF35_2220 ENOG4105C59 p-type ATPase BF35_2221 ENOG4107U9T Pfam:Ribonuclease_BN BF35_2223 ENOG4105KJF protein tyrosine phosphatase BF35_2227 ENOG4108TTB tellurium resistance protein BF35_2228 ENOG4107TS3 membrane protein, TerC BF35_2229 ENOG4106FN3 tellurium resistance protein BF35_2230 ENOG4106FN3 tellurium resistance protein BF35_2231 ENOG4108N0M stress protein BF35_2237 ENOG4105DEU major facilitator superfamily BF35_2240 ENOG41062JF Transcriptional regulator BF35_2246 ENOG4105C5H ABC transporter BF35_225 ENOG4105DBI uridine monophosphokinase BF35_2250 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF35_2253 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BF35_2259 ENOG4105CI1 PTS System BF35_2261 ENOG4105DNP FAD linked oxidase domain protein BF35_2263 ENOG4108W63 CRP FNR family transcriptional regulator BF35_2264 ENOG4105C5B carbamate kinase BF35_2266 ENOG4105DBV ornithine carbamoyltransferase BF35_2269 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF35_2271 ENOG4105EAB amino acid AbC transporter BF35_2272 ENOG4105E5Q amino acid AbC transporter BF35_2275 ENOG4105D2S major facilitator superfamily BF35_2276 ENOG410756H nucleotidyltransferase BF35_228 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF35_2283 ENOG4106UIA BF35_2284 ENOG4106UIA BF35_2288 ENOG4108V5C ABC transporter BF35_2289 ENOG4105DQ5 transport system permease protein BF35_229 ENOG4107QX3 carboxylase BF35_2290 ENOG4105EHG Permease protein BF35_2291 ENOG4107W7X Aldolase BF35_2292 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BF35_2293 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BF35_2294 ENOG4105D3R alkyl hydroperoxide reductase BF35_2299 ENOG4105DFD Na H antiporter BF35_230 ENOG4105E39 Enoyl-CoA hydratase BF35_2300 ENOG4105DTQ mandelate racemase muconate lactonizing BF35_2303 ENOG4108W15 Protein of unknown function (DUF1456) BF35_2304 ENOG4105BZU Histidine kinase BF35_2306 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF35_2307 ENOG4105D9N nucleoside BF35_231 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BF35_2311 ENOG4105KPY Small multidrug resistance protein BF35_2312 ENOG4105C26 Dehydrogenase BF35_2314 ENOG4108JPW Aminotransferase BF35_2315 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BF35_2316 ENOG4105CBD Diacylglycerol kinase BF35_232 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BF35_2320 ENOG4107I77 yiaA/B two helix domain BF35_2321 ENOG410834F Transcriptional regulator BF35_2325 ENOG4105D01 (LipO)protein BF35_2326 ENOG4108UMI ABC transporter, permease BF35_2328 ENOG4108W2Y isochorismatase BF35_233 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF35_2334 ENOG4105C4R Atp-dependent dna helicase BF35_2339 ENOG4105C12 Phosphoribosylglycinamide synthetase BF35_234 ENOG4105C1G acyl-Coa dehydrogenase BF35_2341 ENOG4108V3E phosphoribosylglycinamide formyltransferase BF35_2346 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BF35_2348 ENOG4105C83 adenylosuccinate lyase BF35_2349 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BF35_2350 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BF35_2356 ENOG4105SX7 Transporter BF35_2362 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF35_2367 ENOG4108SHN Glycosyl transferase, family 2 BF35_237 ENOG4107Z3H Transcriptional regulator, TetR family BF35_2371 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF35_2378 ENOG4107ZXU DSBA oxidoreductase BF35_2384 ENOG4105BZU Histidine kinase BF35_2386 ENOG4105C7N Xanthine uracil vitamin C permease BF35_239 ENOG4105CJ1 ABC, transporter BF35_2390 ENOG4108TYN CAAX amino terminal protease family protein BF35_2393 ENOG4105C5H ABC transporter BF35_2395 ENOG410801F ribosomal-protein-alanine acetyltransferase BF35_2396 ENOG41072GX Peptidase M22 Glycoprotease BF35_2397 ENOG4105K8N protein family UPF0079, ATPase BF35_241 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BF35_2417 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BF35_2419 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF35_2420 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BF35_2425 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF35_2426 ENOG4105CPF Cell wall formation (By similarity) BF35_2428 ENOG4105CUB amino acid BF35_243 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF35_2430 ENOG4105ERH Fumarylacetoacetate hydrolase BF35_2431 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BF35_2437 ENOG410667J hydrolase BF35_2438 ENOG4108JQ7 (ABC) transporter BF35_2439 ENOG4105C3U ABC transporter BF35_2440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF35_2442 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BF35_2444 ENOG4105C5H ABC transporter BF35_2448 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BF35_2450 ENOG4108RE7 deoxyribonuclease BF35_2453 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF35_2457 ENOG4105F6E Acyl-transferase BF35_2465 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BF35_2466 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF35_2467 ENOG4105E0C molybdate abc transporter BF35_2471 ENOG4108J59 Extracellular solute-binding protein, family 5 BF35_2472 ENOG4108J59 Extracellular solute-binding protein, family 5 BF35_2475 ENOG4108JQ7 (ABC) transporter BF35_2476 ENOG4105C3U ABC transporter BF35_2477 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF35_2478 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF35_2481 ENOG4105C2C drug resistance transporter, Bcr CflA BF35_2484 ENOG4105IQ5 FAD linked oxidase domain protein BF35_2486 ENOG4105EE1 crotonyl-CoA reductase BF35_2487 ENOG4108PSK reductase BF35_2492 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BF35_2494 ENOG4105CMG Carbohydrate kinase BF35_2496 ENOG4108VQT Alpha beta hydrolase fold protein BF35_2498 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BF35_25 ENOG4105PKS Excinuclease abc c subunit domain protein BF35_2500 ENOG4107U5W ybbr family BF35_2501 ENOG4105C8B TIGR00159 family BF35_2522 ENOG4105D1F ATP-binding protein BF35_2528 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF35_253 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF35_2535 ENOG41067V7 50S ribosomal protein L36 BF35_2537 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF35_2539 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF35_2544 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BF35_2565 ENOG4105XPM ribosomal protein BF35_2568 ENOG4107Y49 methyltransferase BF35_2573 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BF35_2575 ENOG4105QIV RNA polymerase BF35_2576 ENOG4105M0M Tetracycline resistance protein BF35_2577 ENOG4105C2N RNA methyltransferase TrmH family group 3 BF35_2580 ENOG4105D7W serine acetyltransferase BF35_2585 ENOG4105CTP PilT protein domain protein BF35_2587 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BF35_259 ENOG4105BZU Histidine kinase BF35_2590 ENOG4108Z0C Uvrb UvrC protein BF35_2610 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BF35_2612 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BF35_2613 ENOG4105KRF dihydroneopterin aldolase BF35_2614 ENOG4105EEI dihydropteroate synthase BF35_2615 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BF35_2616 ENOG4105DDQ anthranilate synthase BF35_2617 ENOG4105CRQ synthase (Component I) BF35_2618 ENOG4105C6T cysteine synthase BF35_2621 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BF35_2622 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF35_2627 ENOG41060GV RNA binding s1 domain protein BF35_2630 ENOG4105VYY sporulation protein yabp BF35_2631 ENOG41082I2 s4 domain protein BF35_2632 ENOG4108IY2 MazG family BF35_2634 ENOG4108M14 stage v sporulation protein t BF35_2635 ENOG4108JA2 transcriptioN-repair coupling factor BF35_2638 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BF35_264 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF35_2641 ENOG4105KME endoribonuclease L-psp BF35_2642 ENOG4105DFT pur operon repressor BF35_2645 ENOG4105W42 Veg protein BF35_2646 ENOG4105XFA sporulation peptidase YabG BF35_2648 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BF35_2649 ENOG4105F8V Hydrolase, tatD family BF35_265 ENOG4105WH1 Two component transcriptional regulator luxr family BF35_2650 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BF35_2651 ENOG4105KRN Transcriptional regulator, abrb family BF35_2652 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BF35_2654 ENOG41060K3 Methyltransferase BF35_2656 ENOG4105MA4 psp1 domain protein BF35_2657 ENOG4105FA2 dna polymerase iii BF35_2659 ENOG4105CXN decarboxylase BF35_266 ENOG4108XG2 Histidine kinase BF35_2667 ENOG41067KS pro-sigma K processing BF35_267 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF35_2671 ENOG4105C6E dna polymerase iii BF35_2672 ENOG4108Z6B deaminase BF35_2673 ENOG4105GTG Isochorismatase BF35_2675 ENOG4105ZMH deoxynucleoside kinase BF35_2682 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF35_2689 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF35_2692 ENOG410848D S4 domain protein YaaA BF35_2693 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF35_2697 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF35_2703 ENOG4107QJE Chromosome Partitioning Protein BF35_2704 ENOG4105FA0 parb-like partition protein BF35_2705 ENOG4108ZDA Sporulation protein YyaC BF35_2706 ENOG4105D8X mechanosensitive ion channel BF35_2707 ENOG4105VDK protein, conserved in bacteria BF35_2708 ENOG4105C3G gtp-binding protein BF35_2710 ENOG4108UUM single-stranded DNA-binding protein BF35_2712 ENOG4108XMW Membrane BF35_2713 ENOG4105BZR domain protein BF35_2715 ENOG4105CDU Replicative dna helicase BF35_2721 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF35_2722 ENOG4105BZU Histidine kinase BF35_2725 ENOG4105Q2H domain protein BF35_2726 ENOG4105C0H protease BF35_2730 ENOG4105DPN Oligoendopeptidase f BF35_2733 ENOG4105C1J atp-dependent rna helicase BF35_2735 ENOG4108UT2 hemolysin iii BF35_2736 ENOG4105CMR udp-glucose 4-epimerase BF35_2738 ENOG4105IW1 AmiS UreI transporter BF35_2740 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF35_2743 ENOG4107RGD Major Facilitator superfamily BF35_2744 ENOG4108HRK Histidine kinase BF35_2745 ENOG4105DY9 regulatoR BF35_2748 ENOG4106F5Q Membrane BF35_2749 ENOG4105E0X reductase BF35_275 ENOG4105EXC Acyl-transferase BF35_2751 ENOG41067SE Tetr family transcriptional regulator BF35_2752 ENOG4105CKK Glycosyl transferase, family 2 BF35_2756 ENOG4105C5H ABC transporter BF35_2757 ENOG4105JEU Glycosyl transferase, family 2 BF35_2759 ENOG4108S4H thioesterase Superfamily protein BF35_2761 ENOG4106YBV Methyl-accepting chemotaxis BF35_2762 ENOG4105EN6 Membrane BF35_2766 ENOG41079KZ Major Facilitator Superfamily BF35_2767 ENOG4105DY9 regulatoR BF35_2768 ENOG4105D22 carbon starvation protein BF35_2769 ENOG4105VCD cytoplasmic protein BF35_2770 ENOG4105BZU Histidine kinase BF35_2771 ENOG4105DWF phosphomethylpyrimidine kinase BF35_2772 ENOG4105BZU Histidine kinase BF35_2773 ENOG4105WH1 Two component transcriptional regulator luxr family BF35_2775 ENOG4108Y4K DNA-binding transcriptional activator BF35_2780 ENOG4105D6E homoserine dehydrogenase BF35_2783 ENOG41090WU lipolytic protein G-D-S-L family BF35_2784 ENOG4105CJ1 ABC, transporter BF35_2785 ENOG4108TU7 Inherit from COG: (ABC) transporter BF35_2787 ENOG4105VCH membrane BF35_2788 ENOG410667J hydrolase BF35_2790 ENOG4107SVH Potassium channel protein BF35_2794 ENOG4108VKI Cell wall hydrolase BF35_2797 ENOG4108IJ2 phosphate acetyltransferase BF35_280 ENOG4105DH8 myo-inositol catabolism BF35_2800 ENOG4108VCI transcription factor, rsfa family BF35_2802 ENOG4105DQ5 transport system permease protein BF35_2803 ENOG4105EHG Permease protein BF35_2804 ENOG4105E0A ABC, transporter BF35_2805 ENOG4108MES Periplasmic binding protein BF35_2806 ENOG4105DCI Phosphohydrolase BF35_2807 ENOG41069HH 4-oxalocrotonate tautomerase BF35_2808 ENOG4108Z4T Peptidase M50 BF35_2809 ENOG4108XFG YwhD family BF35_281 ENOG4105D2N Aldolase BF35_2810 ENOG4105BZ4 penicillin-binding protein BF35_2811 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF35_2812 ENOG4107SWG transcriptional regulator MERR family BF35_2813 ENOG4105DXB Major Facilitator superfamily BF35_2815 ENOG4105CYW agmatinase BF35_2819 ENOG410684U Domain of unknown function (DUF1934) BF35_2821 ENOG4105JVQ RNA Polymerase BF35_2826 ENOG4105IIU Aminopeptidase BF35_2827 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BF35_2828 ENOG4108M15 ABC transporter BF35_2829 ENOG4105KCT ABC transporter BF35_2830 ENOG4105BZU Histidine kinase BF35_2835 ENOG4105BZU Histidine kinase BF35_2838 ENOG4105DF6 Fe-S oxidoreductase BF35_2842 ENOG4105C1G acyl-Coa dehydrogenase BF35_2843 ENOG4105C1G acyl-Coa dehydrogenase BF35_2850 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BF35_2851 ENOG4105CBT Fructose-1,6-bisphosphatase BF35_2852 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BF35_2855 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BF35_2856 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF35_2857 ENOG4108ZXQ stage ii sporulation protein r BF35_2859 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF35_286 ENOG4105CK5 oxidoreductase BF35_2862 ENOG4107XC4 flavin reductase domain protein, FMN-binding BF35_2863 ENOG4108VGI doxx family BF35_2866 ENOG4108YZG isomerase BF35_2871 ENOG41062M3 atp synthase BF35_2872 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BF35_288 ENOG4105IE8 Alpha-ketoglutarate permease BF35_2882 ENOG4105BZU Histidine kinase BF35_2883 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF35_2885 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF35_2886 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF35_289 ENOG4105ETE Transcriptional regulator (LacI family BF35_2891 ENOG4105D65 subunit l BF35_2892 ENOG4105C8S subunit m BF35_2893 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF35_2894 ENOG4106778 Protein of unknown function (DUF1146) BF35_2898 ENOG4105DY9 regulatoR BF35_290 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF35_2901 ENOG4105FRN stage II sporulation protein BF35_2902 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BF35_2904 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BF35_2905 ENOG4107RZX Teichoic acid biosynthesis protein BF35_2906 ENOG4107SJB teichoic acid biosynthesis BF35_2907 ENOG4105CG5 Glycosyl transferase (Group 1 BF35_2909 ENOG4107SJB teichoic acid biosynthesis BF35_2911 ENOG4105EY8 ABC transporter BF35_2912 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF35_2916 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BF35_2917 ENOG4105CMR udp-glucose 4-epimerase BF35_2918 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF35_2919 ENOG4105BZU Histidine kinase BF35_292 ENOG4107RF6 penicillin-binding protein BF35_2922 ENOG4105CXY transporter BF35_2924 ENOG4105C19 ABC transporter BF35_2925 ENOG4107RBB ABC transporter, permease BF35_293 ENOG4107RF6 penicillin-binding protein BF35_2933 ENOG4105C0D helicase BF35_2934 ENOG4105KBK Zinc finger, swim domain protein BF35_2939 ENOG41069ER domain protein BF35_2940 ENOG4105C94 Transporter BF35_2942 ENOG4107R8N Glycosyl transferase, family 2 BF35_2947 ENOG4105E0M Sulfatase BF35_2950 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BF35_2952 ENOG4105DAA L-lactate BF35_2959 ENOG4107RSM transcriptional regulator BF35_296 ENOG4107RVG penicillin-binding protein BF35_2960 ENOG4105ECB domain protein BF35_2961 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BF35_2964 ENOG4105VZJ PTS System BF35_2966 ENOG4105VCP PTS System BF35_2968 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BF35_2970 ENOG4105CK1 PTS System BF35_2971 ENOG4105VCP PTS System BF35_2972 ENOG4105F8D glycoside hydrolase family 4 BF35_2976 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BF35_2978 ENOG4105ESV Glycosyl transferase, family 4 BF35_2979 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF35_2980 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF35_2981 ENOG4108KGH TRANSCRIPTIONal BF35_2982 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BF35_2984 ENOG4105KVH Transcriptional regulator BF35_2987 ENOG41081UC Inherit from COG: Competence protein BF35_2988 ENOG4105VEQ Cold shock protein BF35_2989 ENOG4105MS2 ribosomal subunit Interface protein BF35_2991 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BF35_2993 ENOG4105CAK Cell division ATP-binding protein ftsE BF35_2994 ENOG4105CRP Part of the ABC transporter FtsEX involved in BF35_2995 ENOG4105CN1 protease BF35_2997 ENOG4105BZ1 (ABC) transporter BF35_3 ENOG4105CIS alcohol dehydrogenase BF35_300 ENOG4105EQK -acetyltransferase BF35_3000 ENOG4108WS4 fmn reductase BF35_3002 ENOG4105DUM transcriptional regulator, lysR family BF35_3003 ENOG4105HMI Membrane BF35_3008 ENOG4107TXC Transcriptional regulator BF35_3011 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BF35_3012 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF35_3014 ENOG41086DT Membrane protein of unknown function BF35_3018 ENOG4108S4C acetyltransferase BF35_302 ENOG4105CIN aminoacyl-histidine dipeptidase BF35_3020 ENOG4105C3M thioredoxin reductase BF35_3022 ENOG4108Z4K mutator MutT protein BF35_3024 ENOG4105CHW UPF0052 protein BF35_3026 ENOG4105KRI phosphocarrier protein (HPr BF35_3027 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF35_3028 ENOG4108QY0 Membrane BF35_3031 ENOG4105CZ3 stage V sporulation protein ad BF35_3032 ENOG41090VF Stage v sporulation protein ac BF35_3036 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF35_3042 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BF35_3046 ENOG41067MG lrgb family BF35_3047 ENOG4105XZU Preprotein translocase, subunit SecG BF35_3049 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BF35_3055 ENOG4105CM4 permease protein BF35_3056 ENOG4108IPW abc transporter atp-binding protein BF35_3058 ENOG4108MK9 spermidine N(1)-acetyltransferase BF35_3059 ENOG4105C5H ABC transporter BF35_306 ENOG4105K56 Transcriptional regulator BF35_3064 ENOG4105WMR Protein CrcB homolog BF35_3066 ENOG4105C8Q Methyl-accepting chemotaxis BF35_3068 ENOG4105D4A Cell wall formation (By similarity) BF35_3069 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF35_307 ENOG4107RA9 decarboxylase BF35_3073 ENOG4105KVH Transcriptional regulator BF35_3074 ENOG4105F27 Major Facilitator BF35_3075 ENOG4105CV8 reductase BF35_3078 ENOG4108RYK Nad-dependent epimerase dehydratase BF35_308 ENOG4108I0C methyltransferase BF35_3081 ENOG4105D9N nucleoside BF35_3082 ENOG4105D9N nucleoside BF35_3086 ENOG4108URH decarboxylase BF35_3090 ENOG4108RMU ferritin dps family protein BF35_3092 ENOG4105NCW Trka-c domain protein BF35_3093 ENOG4107S91 Sodium hydrogen exchanger BF35_3094 ENOG4107T5V SNARE associated Golgi BF35_3098 ENOG4105D4Y metalloprotease BF35_3099 ENOG4105VG1 fes assembly suf system protein BF35_310 ENOG41088CC tellurite resistance protein tehB BF35_3100 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF35_3101 ENOG4105C8Q Methyl-accepting chemotaxis BF35_3105 ENOG4105BZU Histidine kinase BF35_3106 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF35_3107 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF35_3109 ENOG4107ZTW SNARE associated Golgi BF35_311 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF35_3116 ENOG4107AYK membrAne BF35_3118 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF35_3121 ENOG4107R7I amino acid BF35_3122 ENOG4108SUT Major Facilitator Superfamily BF35_3126 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF35_3130 ENOG4105DZ1 carboxypeptidase BF35_3133 ENOG4105CHU acetyl-coa acetyltransferase BF35_3135 ENOG4105C1G acyl-Coa dehydrogenase BF35_3136 ENOG4108W8B Beta-lactamase domain protein BF35_315 ENOG4108RZE Tetr family transcriptional regulator BF35_3153 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF35_3159 ENOG4108UMI ABC transporter, permease BF35_3160 ENOG4105D01 (LipO)protein BF35_3161 ENOG4105D01 (LipO)protein BF35_3162 ENOG4105C3K feS assembly ATPase SufC BF35_3163 ENOG4105JRK feS assembly protein SufD BF35_3164 ENOG4105C9B Cysteine desulfurase BF35_3165 ENOG4108UNV SUF system FeS assembly protein, NifU family BF35_3166 ENOG4105DIW FeS assembly protein SUFB BF35_3169 ENOG4107R8B 5'-nucleotidase BF35_3170 ENOG4105KZD Domain of unknown function (DUF1805) BF35_3172 ENOG4105FAA peptidase M23 BF35_3177 ENOG41090T1 Membrane BF35_3178 ENOG4107TXC Transcriptional regulator BF35_3179 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BF35_318 ENOG4105C1J atp-dependent rna helicase BF35_3180 ENOG4105MMD transcriptional regulator BF35_3183 ENOG4105CBT Fructose-1,6-bisphosphatase BF35_3186 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF35_3188 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF35_3190 ENOG4108W5N phosphatidylglycerophosphatase a BF35_3193 ENOG41083MR nifu domain-containing protein BF35_3197 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BF35_3198 ENOG4105C4B ABC transporter, permease BF35_3199 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF35_32 ENOG4105KWG Pfam:DUF1696 BF35_3203 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BF35_3207 ENOG4105EWC Purine nucleoside phosphorylase BF35_321 ENOG4105D7V transposase BF35_3212 ENOG4105CEP NADH dehydrogenase BF35_3215 ENOG41069ER domain protein BF35_3219 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF35_322 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF35_3222 ENOG4105KA0 thioesterase Superfamily protein BF35_3223 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BF35_3226 ENOG4107R3E Citrate transporter BF35_3228 ENOG4105Y38 Kinase-associated protein B BF35_3231 ENOG4105C87 Aminotransferase class I and II BF35_3233 ENOG4108MUZ hydrolase BF35_3234 ENOG4105C5I Dehydrogenase BF35_3235 ENOG4108ZB6 transcriptional regulator AsnC family BF35_3236 ENOG4105CHM Aminotransferase BF35_3238 ENOG4105WG9 Conserved Protein BF35_3240 ENOG4107PBV potassium channel BF35_3242 ENOG4105KT7 mgtC SapB transporter BF35_3250 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BF35_326 ENOG4108INS Transcriptional regulator BF35_3269 ENOG4105EMN RNA polymerase sigma factor BF35_3271 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF35_3272 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF35_3283 ENOG4105VEQ Cold shock protein BF35_3285 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF35_3286 ENOG4105E4F Isochorismate synthase BF35_3288 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BF35_3289 ENOG4108IPT Naphthoate synthase BF35_3291 ENOG4105DTQ mandelate racemase muconate lactonizing BF35_3295 ENOG41069H0 dihydroorotase EC 3.5.2.3 BF35_3299 ENOG4105FDP GntR family transcriptional regulator BF35_33 ENOG4108NRW Phospholipase, patatin family BF35_330 ENOG4105RD7 BadF BadG BcrA BcrD BF35_3300 ENOG4105C6Z Gluconate BF35_3308 ENOG41082BM Transcriptional regulator, arsr family BF35_3310 ENOG41086D8 Transcriptional regulator BF35_3311 ENOG4105C19 ABC transporter BF35_3315 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BF35_3316 ENOG4107ZTW SNARE associated Golgi BF35_3321 ENOG4108HVR ABC transporter, permease BF35_3325 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BF35_3326 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF35_3331 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF35_3332 ENOG4105BZU Histidine kinase BF35_3333 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BF35_3338 ENOG4108IBT Inherit from COG: transposase BF35_3341 ENOG41087YS Phage shock protein A BF35_335 ENOG4105F32 YngK protein BF35_3351 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF35_3352 ENOG4105C4M (Ubiquinol oxidase) subunit I BF35_3354 ENOG4108V2W Carbonate dehydratase BF35_3364 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BF35_3366 ENOG4105D2X ABC transporter substrate-binding protein BF35_3369 ENOG4107T7U Sulfatase BF35_3370 ENOG4107S9D Alpha beta hydrolase BF35_3371 ENOG4105BZU Histidine kinase BF35_3372 ENOG4105BZU Histidine kinase BF35_3386 ENOG4108MK9 spermidine N(1)-acetyltransferase BF35_3389 ENOG4108RIR Molybdenum cofactor biosynthesis protein BF35_3391 ENOG4105BZF Glycosyl transferase (Group 1 BF35_3392 ENOG4105YVM Phosphoesterase, PA-phosphatase related BF35_3393 ENOG4108Z0R Transferase BF35_3394 ENOG4105E8V Alpha Beta Hydrolase Fold protein BF35_340 ENOG4108KPJ rna polymerase sigma factor BF35_3401 ENOG4105CIG ABC transporter BF35_3403 ENOG4105N5T Radical SAM Protein BF35_3407 ENOG4105C19 ABC transporter BF35_3410 ENOG4105NCW Trka-c domain protein BF35_3411 ENOG4107S91 Sodium hydrogen exchanger BF35_3412 ENOG410605W Major Facilitator BF35_3418 ENOG4108B31 Spore germination protein BF35_3420 ENOG4105DWV Homoserine O-trans-acetylase BF35_3422 ENOG41085GJ domain protein BF35_3426 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF35_3427 ENOG4105D06 uba thif-type nad fad binding protein BF35_3429 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF35_343 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF35_3430 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BF35_3431 ENOG4108ZAF Molybdopterin BF35_3435 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BF35_3436 ENOG4108VJ1 Transcriptional regulator (CarD family BF35_3443 ENOG4105CBX hi0933 family BF35_3446 ENOG4105YW5 deoR family transcriptional regulator BF35_3447 ENOG4107QSE Dipeptidase BF35_3449 ENOG4108IUM Glycogen debranching enzyme BF35_3450 ENOG4108V15 phosphotransferase enzyme family BF35_3453 ENOG4105C8F Beta-lactamase domain protein BF35_3459 ENOG4108VDD TRNA binding domain protein BF35_3466 ENOG4105K7K Transcriptional regulator BF35_3468 ENOG4108IPJ Membrane BF35_3473 ENOG4105C88 aminopeptidase BF35_3477 ENOG4105ETE Transcriptional regulator (LacI family BF35_3483 ENOG4105EP9 oxidoreductase BF35_3484 ENOG4107SNB ankyrin repeat protein YahD BF35_3486 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF35_3489 ENOG4105DGU Histone deacetylase BF35_3490 ENOG4105W87 Cbs domain BF35_3491 ENOG4105F1V Acetoin utilization protein BF35_3494 ENOG4105EMN RNA polymerase sigma factor BF35_350 ENOG4108JCI Transcriptional regulator BF35_3500 ENOG4105C28 cystathionine BF35_3502 ENOG4105U5Y Transcriptional regulator BF35_3504 ENOG4105C5Q Transcriptional regulator BF35_3509 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF35_3511 ENOG4105EFZ amidohydrolase BF35_3514 ENOG4105KBJ sporulation protein ytfj BF35_3515 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BF35_3521 ENOG4108JYZ YitT family BF35_3529 ENOG4107YZX Universal stress protein BF35_3534 ENOG4105VZ8 Transcriptional regulator BF35_3536 ENOG41082W1 Cupin 2, conserved barrel domain protein BF35_3537 ENOG4105Z7P Acetyltransferase (GNAT) family BF35_354 ENOG4105BZ1 (ABC) transporter BF35_3545 ENOG4105DC7 peptidase M24 BF35_355 ENOG4105BZ1 (ABC) transporter BF35_3551 ENOG4105SFS phosphoesterase RecJ domain protein BF35_3553 ENOG4105VV2 BF35_3554 ENOG4105C0B DNA polymerase III (alpha subunit) BF35_3555 ENOG4105C6K Malic enzyme BF35_3556 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF35_3561 ENOG4105FS0 cytoplasmic membrane protein BF35_3562 ENOG4108REF Sporulation integral membrane protein ytvi BF35_3564 ENOG4105BZN citrate synthase BF35_3565 ENOG4108HMX isocitrate dehydrogenase (NADP) BF35_3570 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF35_3571 ENOG4105BZU Histidine kinase BF35_3572 ENOG4105C2M dna polymerase I BF35_3575 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BF35_3576 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BF35_3577 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF35_358 ENOG4108RPX mosc domain containing protein BF35_3581 ENOG4108TDW sporulation protein YtxC BF35_3582 ENOG4105C22 threonyL-tRNA synthetase BF35_3583 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BF35_3587 ENOG4105CN9 Peptidase m42 family protein BF35_3588 ENOG4108JGH Tetr family transcriptional regulator BF35_3589 ENOG4105CW7 secretion protein, HlyD family BF35_359 ENOG4105DND Transcriptional regulator BF35_3590 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF35_3594 ENOG4108RWN rrna methyltransferase BF35_3596 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BF35_3597 ENOG4105C5S asparaginyl-tRNA synthetase BF35_3601 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BF35_3604 ENOG4105DCG PHP domain protein BF35_3607 ENOG4105FE9 pseudouridine synthase BF35_3609 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BF35_3611 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BF35_3614 ENOG4105E0A ABC, transporter BF35_3615 ENOG4105KFN sortase, SrtB family BF35_3617 ENOG4105DR4 Methyltransferase BF35_362 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF35_3620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF35_363 ENOG4107V2S Transcriptional regulator BF35_3630 ENOG4105CEY Amp-dependent synthetase and ligase BF35_3631 ENOG4107Z3H Transcriptional regulator, TetR family BF35_3632 ENOG41060WC Enoyl-CoA hydratase BF35_3633 ENOG4105BZJ Electron transfer flavoprotein BF35_3634 ENOG4105C10 Electron transfer flavoprotein BF35_3635 ENOG4105K63 Thioredoxin BF35_3638 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BF35_3640 ENOG4105E33 succinate dehydrogenase BF35_3642 ENOG4108VXD carboxy-peptidase BF35_3643 ENOG4105E14 MotA TolQ exbB proton channel BF35_3644 ENOG4105ER2 Ompa motb domain protein BF35_3645 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BF35_3646 ENOG4108IUX (ABC) transporter BF35_3647 ENOG4105RHA ABC transporter, permease BF35_3648 ENOG4108Z40 Transcriptional regulator BF35_3649 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BF35_365 ENOG410667J hydrolase BF35_3651 ENOG4108JCI Transcriptional regulator BF35_3652 ENOG41067S9 phage shock protein C, PspC BF35_3653 ENOG4105DZC cytosine deaminase BF35_3655 ENOG4105PFC Transcriptional regulator BF35_3658 ENOG4105KBX Transcriptional regulator, TetR family BF35_3660 ENOG4108PCX Major Facilitator BF35_3662 ENOG4108XJQ germination protein BF35_3665 ENOG4105M59 Phosphodiesterase, mj0936 family BF35_3677 ENOG4108IUQ atp-dependent protease BF35_3681 ENOG4105K56 Transcriptional regulator BF35_3686 ENOG4105D52 delta-aminolevulinic acid dehydratase BF35_3688 ENOG41068KH stage VI sporulation protein D BF35_369 ENOG4105VEQ Cold shock protein BF35_3691 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BF35_3696 ENOG4105EKQ RNA-directed DNA polymerase BF35_3698 ENOG4105DFF Rod shape-determining protein mreb BF35_3699 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BF35_370 ENOG41068WN BF35_3702 ENOG4107QMS site-determining protein BF35_3705 ENOG4105C03 ribonuclease BF35_3707 ENOG4105X36 (ribosomal) protein BF35_3710 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BF35_3712 ENOG4105EWM Histidine kinase BF35_3716 ENOG4105CQC Prephenate dehydratase BF35_3717 ENOG4108RPX mosc domain containing protein BF35_372 ENOG4105C1Q protoporphyrinogen oxidase BF35_3720 ENOG4108IYU L-aspartate oxidase BF35_3721 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BF35_3726 ENOG41082BM Transcriptional regulator, arsr family BF35_3727 ENOG4108IPJ Membrane BF35_3729 ENOG4108HUF Transporter BF35_373 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BF35_3732 ENOG41061AI Protein of unknown function (DUF2905) BF35_3735 ENOG4105VIE preprotein translocase, subunit YajC BF35_3737 ENOG4108QG2 Membrane BF35_3738 ENOG4105CKP Polysaccharide Biosynthesis Protein BF35_3740 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BF35_3741 ENOG41076HS cation diffusion facilitator family transporter BF35_3742 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF35_3744 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF35_3747 ENOG4105CUT histidyl-tRNA synthetase BF35_3749 ENOG4105CUZ uba thif-type nad fad binding protein BF35_3750 ENOG4108VCI transcription factor, rsfa family BF35_3751 ENOG4105D1H recombination factor protein RarA BF35_3753 ENOG4105C3J Cysteine desulfurase BF35_3756 ENOG4105C7H Helicase, RecD TraA family BF35_3757 ENOG41060CR BF35_3760 ENOG4105C02 permease BF35_3766 ENOG4105HHA aminodeoxychorismate lyase BF35_3767 ENOG4108VQJ O-methyltransferase BF35_3768 ENOG4105XYU peptidase (U32 family) BF35_3769 ENOG4105CFP Peptidase U32 BF35_3772 ENOG4107XRG penicillin-binding protein BF35_3778 ENOG4105C28 cystathionine BF35_3779 ENOG4108EKI Dehydrogenase BF35_378 ENOG4105WCN acetyltransferase BF35_3781 ENOG4108V5C ABC transporter BF35_3782 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF35_3791 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF35_3793 ENOG4105MIR Phenylalanine 4-monooxygenase BF35_3794 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF35_38 ENOG4108XI2 Domain of unknown function (DUF1963) BF35_3801 ENOG4108MUZ hydrolase BF35_3802 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BF35_3803 ENOG4105G6Z alkaline phosphatase BF35_3806 ENOG4108TVJ Nitroreductase BF35_3810 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF35_3813 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF35_3814 ENOG4105CQW ribosome biogenesis GTPase YqeH BF35_3816 ENOG410812S Rna-binding protein BF35_3818 ENOG4108WF2 Metal Dependent Phosphohydrolase BF35_3820 ENOG4105DXX methyltransferase BF35_3822 ENOG4105KQC Competence protein BF35_3823 ENOG4108UK2 deaminase BF35_3824 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF35_3826 ENOG4105TQK DNA polymerase iii, delta' subunit BF35_383 ENOG4105EYF MMPL domain protein BF35_3831 ENOG4105KVH Transcriptional regulator BF35_3832 ENOG4105CSA Coproporphyrinogen iii oxidase BF35_3838 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BF35_3839 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF35_3841 ENOG4105KTH gatB Yqey BF35_3842 ENOG41068P3 sporulation protein YqfC BF35_3844 ENOG4105C9A Phoh family BF35_3845 ENOG4105CTJ Metal Dependent Phosphohydrolase BF35_3847 ENOG4107YR5 Diacylglycerol kinase BF35_3848 ENOG4105KG3 cytidine deaminase BF35_3849 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BF35_385 ENOG4105C5X domain protein BF35_3854 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BF35_3855 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF35_3858 ENOG4105EGD dinuclear metal center protein, YbgI family BF35_3863 ENOG41069ZM Protein of unknown function (DUF2624) BF35_3864 ENOG4108JYZ YitT family BF35_3865 ENOG4105FDK ABC transporter BF35_3867 ENOG4105N80 Ferric uptake regulator, Fur family BF35_3872 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF35_3874 ENOG4107RF6 penicillin-binding protein BF35_3875 ENOG4105PWN phosphate abc transporter BF35_3876 ENOG4105C8U phosphate abc transporter BF35_3877 ENOG4105E2Z phosphate ABC transporter (Permease BF35_3878 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BF35_3879 ENOG4108UTW Plays a role in the regulation of phosphate uptake BF35_388 ENOG4107RU9 Transcriptional regulator, Crp Fnr family BF35_3882 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BF35_3884 ENOG4105DKQ ROK family BF35_3886 ENOG4105C5X domain protein BF35_3890 ENOG4105C28 cystathionine BF35_3891 ENOG4105C28 cystathionine BF35_3893 ENOG4105C3R Methionine synthase BF35_390 ENOG41081I9 integral membrane protein BF35_3931 ENOG4105C0D helicase BF35_3937 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF35_3945 ENOG41080TC multidrug resistance protein BF35_395 ENOG4108D32 Methyltransferase BF35_3950 ENOG4105WZW rhodanese family BF35_3951 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BF35_3958 ENOG4107YBY Hydrolase BF35_3959 ENOG4105CBJ Metal-dependent enzyme BF35_3962 ENOG4105DC7 peptidase M24 BF35_3967 ENOG4105CD2 stage iii sporulation protein aa BF35_3968 ENOG4105KR5 Stage iii sporulation protein BF35_3969 ENOG4108CQH stage III sporulation protein AC BF35_3970 ENOG4105KQ4 Stage iii sporulation protein ad BF35_3972 ENOG410644B Stage III sporulation protein af BF35_3977 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF35_3978 ENOG4108ZSR alkaline shock protein BF35_3983 ENOG4105CTB Polyprenyl synthetase BF35_3985 ENOG4105DX0 Hemolysin A BF35_3987 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BF35_3988 ENOG4105S1Z Stage IV sporulation protein B BF35_3989 ENOG4107QQR Sporulation BF35_3991 ENOG41062GF Polar chromosome segregation protein BF35_4009 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF35_4011 ENOG4108JUB Transcriptional regulator BF35_4013 ENOG4107RDP Dehydrogenase BF35_4014 ENOG4105CKM Branched-chain carboxylic acid kinase BF35_4017 ENOG4105CPP Dehydrogenase, E1 component BF35_4018 ENOG4105C7S Dehydrogenase BF35_402 ENOG4105C19 ABC transporter BF35_4020 ENOG4108QY0 Membrane BF35_4022 ENOG4105G7B Protein of unknown function (DUF2992) BF35_4024 ENOG4108HW3 (ABC) transporter BF35_4025 ENOG4105E5Q amino acid AbC transporter BF35_4026 ENOG4105CDA abc transporter atp-binding protein BF35_4027 ENOG4108QEG Membrane BF35_4028 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BF35_4030 ENOG4105D9U N-acetyltransferase BF35_4031 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF35_4032 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF35_4036 ENOG4105EJQ L-serine dehydratase BF35_4037 ENOG4105II7 pyrroline-5-carboxylate reductase BF35_4038 ENOG41069FQ Metallo-beta-lactamase superfamily BF35_4039 ENOG4108IXY short-chain dehydrogenase reductase BF35_404 ENOG4105C22 threonyL-tRNA synthetase BF35_405 ENOG4105FE9 pseudouridine synthase BF35_4050 ENOG4105CGH 5'-nucleotidase BF35_4051 ENOG4105DFD Na H antiporter BF35_4053 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF35_4056 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF35_4057 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF35_4062 ENOG4108R6K riboflavin synthase, subunit alpha BF35_4063 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BF35_4067 ENOG4108YM7 Gcn5-related n-acetyltransferase BF35_4068 ENOG4105ETE Transcriptional regulator (LacI family BF35_4070 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF35_4074 ENOG4105RHY Pfam:UPF0157 BF35_4076 ENOG4105CPC Aldo Keto reductase BF35_4080 ENOG4105MZ9 stage II sporulation protein m BF35_4081 ENOG4105I3K Ferric uptake regulator, Fur family BF35_4083 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF35_4088 ENOG4105D7N magnesium and cobalt transport protein CorA BF35_409 ENOG4105BZG amino acid carrier protein BF35_4095 ENOG4105DVE abc transporter atp-binding protein BF35_4096 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF35_4097 ENOG4105DZ1 carboxypeptidase BF35_4098 ENOG41082AN stage II sporulation protein BF35_4100 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF35_4101 ENOG4105C8J )-transporter BF35_4105 ENOG41090VF Stage v sporulation protein ac BF35_4106 ENOG4105CZ3 stage V sporulation protein ad BF35_4108 ENOG4105G6R Stage v sporulation protein ae BF35_4110 ENOG4105J7I hydrolase BF35_4111 ENOG4105PTM secreted protein BF35_4112 ENOG4107ZE5 PPIases accelerate the folding of proteins BF35_4119 ENOG4105CE4 GlcNAc 6-P deacetylase BF35_4121 ENOG4105FDP GntR family transcriptional regulator BF35_4123 ENOG4105CID antiterminator BF35_4126 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BF35_413 ENOG4105K70 DNA-binding protein BF35_4130 ENOG4106TD9 Diguanylate cyclase BF35_4132 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF35_4140 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BF35_4144 ENOG4105DTD Dehydrogenase BF35_4145 ENOG4105K7K Transcriptional regulator BF35_4152 ENOG4105CHU acetyl-coa acetyltransferase BF35_4153 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BF35_416 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF35_4161 ENOG4105CG3 alpha amylase, catalytic region BF35_4163 ENOG4107FKK extracellular solute-binding protein family 1 BF35_4165 ENOG4105EG2 ABC transporter, permease BF35_4166 ENOG4105FKQ transcriptional regulator BF35_4167 ENOG4105CHM Aminotransferase BF35_4169 ENOG4108HGU Histidine kinase BF35_418 ENOG4105CEY Amp-dependent synthetase and ligase BF35_4180 ENOG4105UIN BF35_4182 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF35_4185 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BF35_4186 ENOG4105EPM Diguanylate phosphodiesterase BF35_4187 ENOG4105EPM Diguanylate phosphodiesterase BF35_419 ENOG4105WQI isochorismatase BF35_4190 ENOG4107IN1 Protein of unknown function (DUF1797) BF35_4192 ENOG4108XRC Protein of unknown function (DUF458) BF35_4199 ENOG4107ZYR domain protein BF35_420 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BF35_4200 ENOG4105CN5 Metallo-Beta-Lactamase BF35_4202 ENOG4108X4Q Hydrolase BF35_4203 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF35_4206 ENOG4105CPP Dehydrogenase, E1 component BF35_421 ENOG4105E4F Isochorismate synthase BF35_4216 ENOG4105CXN decarboxylase BF35_422 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BF35_4220 ENOG4105ECY inositol monophosphatase BF35_4222 ENOG4105CI3 gtp-binding protein typa BF35_4223 ENOG4105QA2 BF35_4227 ENOG4108IAB Phoh family BF35_423 ENOG4105FCD Major Facilitator BF35_4230 ENOG4105CNI cell division protein FtsW BF35_4231 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BF35_4240 ENOG4106UY4 Inherit from COG: Scp-like extracellular BF35_4243 ENOG4107TB6 phosphoglycerate mutase BF35_4247 ENOG4106H78 methyltransferase BF35_4248 ENOG4105H20 Sporulation integral membrane protein YlbJ BF35_4250 ENOG4105D78 K07001 NTE family protein BF35_4251 ENOG41063PX domain protein BF35_4253 ENOG4105KNH Nucleic acid-binding protein BF35_4260 ENOG41068DC Essential cell division protein (By similarity) BF35_4261 ENOG4105CJN penicillin-binding protein BF35_4262 ENOG4105CJN penicillin-binding protein BF35_4263 ENOG4105CJN penicillin-binding protein BF35_4264 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF35_4267 ENOG4105CNI cell division protein FtsW BF35_4268 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF35_4270 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BF35_4271 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BF35_4272 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BF35_4274 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF35_4276 ENOG4105WR5 sporulation protein, YlmC YmxH family BF35_4277 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BF35_4278 ENOG4105DFA alanine racemase domain protein BF35_428 ENOG4107RFY SbcCD D subunit BF35_4280 ENOG41067XK integral membrane protein BF35_4281 ENOG4105DBK s4 domain protein BF35_4286 ENOG4105C34 Pseudouridine synthase BF35_4303 ENOG4105DC7 peptidase M24 BF35_4305 ENOG4105F23 Fibronectin-binding protein BF35_4307 ENOG4105DSJ YicC domain protein BF35_431 ENOG4105E39 Enoyl-CoA hydratase BF35_4311 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BF35_4312 ENOG4105C25 Primosomal protein n' BF35_4313 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF35_4315 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF35_4317 ENOG4108ZF3 Phosphatase BF35_4318 ENOG4105D9P serine threonine protein kinase BF35_432 ENOG4105N14 lysine exporter protein LysE YggA BF35_4320 ENOG4105DJV ribulose-phosphate 3-epimerase BF35_4321 ENOG4105FJ0 thiamine BF35_4323 ENOG4108ZAA Alkaline-shock protein BF35_4324 ENOG4105DP4 dak2 domain fusion protein ylov BF35_4325 ENOG4105CB5 ATP-dependent DNA helicase recG BF35_4328 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BF35_4329 ENOG4105CHR reductase BF35_4332 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BF35_4333 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BF35_4337 ENOG4105VB6 UPF0109 protein BF35_434 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF35_4342 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BF35_4345 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BF35_4346 ENOG4105C79 DNA protecting protein DprA BF35_4347 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF35_4349 ENOG4108HE4 integrase family BF35_435 ENOG4105C1G acyl-Coa dehydrogenase BF35_4358 ENOG4105KNE Phosphatidate cytidylyltransferase BF35_436 ENOG4105CR4 methylisocitrate lyase BF35_4360 ENOG4105DZP Membrane-associated zinc metalloprotease BF35_4362 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF35_4364 ENOG4105CHV Transcription elongation factor NusA BF35_4365 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BF35_4366 ENOG4105VHM ribosomal protein BF35_4368 ENOG4105W7A Protein of unknown function (DUF503) BF35_437 ENOG4105DXD 2-methylcitrate dehydratase BF35_4371 ENOG4105DTN riboflavin biosynthesis protein ribF BF35_4375 ENOG4105C1V Peptidase, M16 BF35_4377 ENOG4105E35 Dipicolinate synthase subunit A BF35_4378 ENOG4108S0H Dipicolinic acid synthetase, b subunit BF35_4379 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF35_4381 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF35_4383 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BF35_4385 ENOG4107QZI cell division protein FtsK BF35_4387 ENOG4105FDP GntR family transcriptional regulator BF35_4388 ENOG4105DIH basic membrane BF35_4389 ENOG4108JQ9 ABC transporter BF35_439 ENOG4105CZM Major Facilitator BF35_4390 ENOG4105UIB (ABC) transporter BF35_4394 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BF35_4395 ENOG4105XZV Protein of unknown function (DUF3243) BF35_4398 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BF35_4402 ENOG4105D48 metallophosphoesterase BF35_4403 ENOG4105MCT stage V sporulation protein S BF35_4404 ENOG4108IGT Dipeptidase BF35_4405 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BF35_4406 ENOG4105DQU oxidoreductase, subunit beta BF35_441 ENOG4105BZ4 penicillin-binding protein BF35_4412 ENOG4107QHE Choloylglycine hydrolase BF35_4414 ENOG410890F Dynamin family BF35_4415 ENOG4105E0M Sulfatase BF35_4417 ENOG4105F0V Cell wall hydrolase BF35_4423 ENOG41067MG lrgb family BF35_4425 ENOG4107ZY0 Phenazine biosynthesis-like protein BF35_4427 ENOG4105C5E polysaccharide biosynthesis protein BF35_4431 ENOG4105BZU Histidine kinase BF35_4437 ENOG4105D03 DNA-3-methyladenine glycosylase II BF35_4438 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF35_4440 ENOG4105CGK Exodeoxyribonuclease III BF35_4444 ENOG4105E0A ABC, transporter BF35_4445 ENOG4105NIV Esterase BF35_4447 ENOG4105VPX protein, conserved in bacteria BF35_4448 ENOG410681U heavy metal transport detoxification protein BF35_4449 ENOG4105C59 p-type ATPase BF35_445 ENOG4105CHR reductase BF35_4451 ENOG4105K70 DNA-binding protein BF35_4452 ENOG4105TMB Formate nitrite transporter BF35_4455 ENOG4105C85 amino acid BF35_4458 ENOG4108SJC Membrane BF35_4459 ENOG4107QW4 alcohol dehydrogenase BF35_4460 ENOG4105E98 transcriptional regulator DeoR family BF35_4461 ENOG4105DE4 1-phosphofructokinase BF35_4462 ENOG4105DM4 PTS System BF35_4463 ENOG41069ER domain protein BF35_4469 ENOG4106F1P AAA ATPase, central domain protein BF35_4471 ENOG4105EN6 Membrane BF35_4472 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF35_4473 ENOG4105CXI aluminum resistance protein BF35_4474 ENOG4105KV4 Transcriptional regulator BF35_4475 ENOG4105C5F glutamine synthetase BF35_4481 ENOG4105K7K Transcriptional regulator BF35_4485 ENOG4108SVB resolvase BF35_4487 ENOG4105CGH 5'-nucleotidase BF35_4488 ENOG4108HW3 (ABC) transporter BF35_4495 ENOG4105BZ1 (ABC) transporter BF35_4496 ENOG4105BZ1 (ABC) transporter BF35_4499 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF35_45 ENOG4108Z4K mutator MutT protein BF35_4504 ENOG41067MG lrgb family BF35_4506 ENOG4107RSM transcriptional regulator BF35_4508 ENOG4105CJ1 ABC, transporter BF35_451 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF35_4510 ENOG4105CH2 amidohydrolase BF35_4512 ENOG4107QIV Cytochrome c biogenesis protein BF35_4525 ENOG4108903 Formimidoylglutamase BF35_4526 ENOG4108VJ1 Transcriptional regulator (CarD family BF35_4527 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF35_4528 ENOG4105CBC glutamate synthase BF35_4530 ENOG4105CK7 Sodium proline symporter BF35_4531 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BF35_4532 ENOG4105FBA Phospholipase Carboxylesterase BF35_4533 ENOG4105BZU Histidine kinase BF35_4535 ENOG4107AYK membrAne BF35_4545 ENOG4108IMY Transcriptional regulator BF35_4548 ENOG4105CEY Amp-dependent synthetase and ligase BF35_4549 ENOG4107ZYJ bioY protein BF35_4550 ENOG4107F3J Amp-dependent synthetase and ligase BF35_4554 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF35_4556 ENOG4105E5W Transporter BF35_4562 ENOG4108I0Z Aconitate hydratase BF35_4563 ENOG4108JJA ABC, transporter BF35_4565 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF35_4566 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF35_4571 ENOG4105D7V transposase BF35_4573 ENOG4105W8X HesB YadR YfhF-family protein BF35_4575 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BF35_4576 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) BF35_4577 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF35_4578 ENOG4105C0H protease BF35_4579 ENOG4105K4P CoA-binding domain protein BF35_4580 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF35_4582 ENOG4105D9R oxidoreductase BF35_4586 ENOG4105CIG ABC transporter BF35_4589 ENOG4105EMN RNA polymerase sigma factor BF35_459 ENOG4108AEY RNA polymerase sigma factor BF35_4591 ENOG4108KGH TRANSCRIPTIONal BF35_4592 ENOG4107QJT sodium dicarboxylate symporter BF35_46 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF35_4604 ENOG4105CUB amino acid BF35_4607 ENOG4105E1K spore germination protein BF35_4608 ENOG4108JB9 formate dehydrogenase BF35_4610 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BF35_4611 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF35_4613 ENOG4105TMB Formate nitrite transporter BF35_4614 ENOG4105D06 uba thif-type nad fad binding protein BF35_4615 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF35_4616 ENOG4108ZAF Molybdopterin BF35_4618 ENOG4105D1F ATP-binding protein BF35_4621 ENOG410696E Membrane BF35_4622 ENOG4105FR1 rard protein BF35_4624 ENOG4105EWU Squalene--hopene cyclase BF35_4626 ENOG4105CHR reductase BF35_4627 ENOG4105C26 Dehydrogenase BF35_4629 ENOG4108IA2 Sodium pantothenate symporter BF35_4632 ENOG4106IQC argininosuccinate lyase BF35_4634 ENOG410904N short-chain dehydrogenase reductase BF35_4637 ENOG4105M6F mutator MutT protein BF35_4641 ENOG4105VEQ Cold shock protein BF35_4645 ENOG4108R1P BF35_4649 ENOG4105IYK transposase BF35_4650 ENOG4105DQ6 Transposase BF35_4651 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF35_4654 ENOG4105KT7 mgtC SapB transporter BF35_4656 ENOG4105BZU Histidine kinase BF35_4661 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity BF35_4662 ENOG41067SE Tetr family transcriptional regulator BF35_4665 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BF35_4669 ENOG4105CQB FAD linked oxidase domain protein BF35_4670 ENOG4105C09 Bile acid BF35_4675 ENOG4105CIS alcohol dehydrogenase BF35_4676 ENOG41082BM Transcriptional regulator, arsr family BF35_4678 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF35_4684 ENOG4108A04 Beta-lactamase BF35_4690 ENOG4105DPN Oligoendopeptidase f BF35_4691 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BF35_4692 ENOG4105E5K Alpha-amylase BF35_4694 ENOG4105C98 muts2 protein BF35_4697 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF35_4699 ENOG4107V2S Transcriptional regulator BF35_47 ENOG4105E09 nadh pyrophosphatase BF35_4701 ENOG4107CUJ Protein of unknown function (DUF2690) BF35_4702 ENOG41068WN BF35_4706 ENOG4105NX3 Membrane BF35_4707 ENOG4105DQ5 transport system permease protein BF35_4708 ENOG4105EHG Permease protein BF35_4709 ENOG4108MES Periplasmic binding protein BF35_471 ENOG4105SZ6 Thioredoxin BF35_4712 ENOG4107R3E Citrate transporter BF35_4714 ENOG4108TN2 lmbE family BF35_472 ENOG410841Q phosphoesterase PA-phosphatase related protein BF35_4723 ENOG4105K7K Transcriptional regulator BF35_4732 ENOG4105H3G oxidoreductase BF35_4739 ENOG4107YXZ hydrolase, family 25 BF35_474 ENOG4108N23 SpoOM-related protein BF35_4742 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BF35_4748 ENOG4105KAF membrAne BF35_4756 ENOG4108ZJ4 polysaccharide deacetylase BF35_4760 ENOG4105KVH Transcriptional regulator BF35_4761 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BF35_4763 ENOG4105KNA -acetyltransferase BF35_4765 ENOG4105CHR reductase BF35_4768 ENOG4105JAB phenazine biosynthesis protein, phzf family BF35_4775 ENOG4105D9R oxidoreductase BF35_4776 ENOG4108TZY GntR Family Transcriptional Regulator BF35_4781 ENOG4105C44 Serine transporter BF35_4786 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF35_4789 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF35_4790 ENOG4105C6Z Gluconate BF35_4791 ENOG4105CMG Carbohydrate kinase BF35_4792 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BF35_4793 ENOG4105XDF Protein of unknown function (DUF1272) BF35_4794 ENOG4105DDN Pentapeptide repeat-containing protein BF35_4799 ENOG4105FAW cDP-glucose 4,6-dehydratase BF35_4800 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BF35_4803 ENOG4105C37 (CBS) domain BF35_4810 ENOG4105EV4 Multidrug resistance protein mdtH BF35_4812 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BF35_4818 ENOG4105C31 Tryptophanyl-tRNA synthetase BF35_482 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BF35_4820 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF35_4822 ENOG4108UW5 maltose o-acetyltransferase BF35_4823 ENOG4105DKQ ROK family BF35_4824 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BF35_483 ENOG4108JUB Transcriptional regulator BF35_4837 ENOG4105CJ1 ABC, transporter BF35_4839 ENOG4108PSK reductase BF35_484 ENOG4108TSC N-acetyltransferase BF35_4843 ENOG4108RCM Nitroreductase BF35_4844 ENOG4105KVH Transcriptional regulator BF35_4848 ENOG4108Z66 YbaK ebsC protein BF35_485 ENOG4107S4Y M20 DapE family protein YgeY BF35_4850 ENOG41067QW Transcriptional regulator BF35_4853 ENOG4108K8S endonuclease I BF35_4858 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF35_4866 ENOG4105CRW Short chain fatty acid transporter BF35_4870 ENOG4105CZM Major Facilitator BF35_4871 ENOG4107MII Sugar-specific transcriptional regulator TrmB BF35_4874 ENOG4108ISG Major Facilitator BF35_4876 ENOG4105PNM synthesis protein BF35_4877 ENOG4108VXD carboxy-peptidase BF35_488 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF35_4884 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF35_4887 ENOG410874W AraC family transcriptional regulator BF35_4888 ENOG41082W1 Cupin 2, conserved barrel domain protein BF35_4892 ENOG4108JQ1 Dehydrogenase BF35_4895 ENOG4105DVH amino acid BF35_4897 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BF35_4900 ENOG4108JPW Aminotransferase BF35_4902 ENOG4105EJQ L-serine dehydratase BF35_4903 ENOG4105C44 Serine transporter BF35_4918 ENOG4105TRI Hydrolase BF35_4922 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF35_4925 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF35_4927 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BF35_4928 ENOG4108U05 Transcriptional regulator BF35_493 ENOG4105C37 (CBS) domain BF35_4931 ENOG4105BZU Histidine kinase BF35_4934 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BF35_4938 ENOG4105JQZ Methyltransferase BF35_4943 ENOG4105VZ8 Transcriptional regulator BF35_4947 ENOG4105K6H D-cysteine desulfhydrase BF35_4953 ENOG4108NIW Leucine export protein LeuE BF35_4957 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF35_4958 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BF35_4961 ENOG4105N0V mono-oxygenase ydhR BF35_4972 ENOG4108YXU transcriptional regulator AsnC family BF35_4973 ENOG4105CHR reductase BF35_4974 ENOG4108IG5 Transcriptional regulator BF35_4975 ENOG4107P5I polyketide synthase BF35_4988 ENOG4105NAE bifunctional deaminase-reductase domain protein BF35_4990 ENOG41085FC arsR family transcriptional regulator BF35_4991 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BF35_4992 ENOG4105D6J arsenicaL-resistance protein BF35_4998 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF35_5 ENOG4105FDR Membrane BF35_50 ENOG4105FCD Major Facilitator BF35_500 ENOG4105E90 ABC transporter BF35_5000 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BF35_5001 ENOG4108TWJ NADH dehydrogenase subunit 5 BF35_5004 ENOG4105F2M alpha beta hydrolase fold-3 domain protein BF35_5008 ENOG4105CVP deoxyribo-dipyrimidine photolyase BF35_501 ENOG4108IJ8 ABC transporter BF35_5010 ENOG4108606 TspO/MBR family BF35_5031 ENOG4105CHJ isochorismatase hydrolase BF35_5033 ENOG4105CGH 5'-nucleotidase BF35_5041 ENOG4105CSV Glutaminase BF35_5045 ENOG4108Q8B Spore germination protein BF35_5046 ENOG4108NHD germination protein BF35_5047 ENOG4105II7 pyrroline-5-carboxylate reductase BF35_5048 ENOG4105CUB amino acid BF35_5049 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF35_5050 ENOG41075H3 AraC family transcriptional regulator BF35_5055 ENOG4105BZU Histidine kinase BF35_5057 ENOG4108B31 Spore germination protein BF35_5059 ENOG4108IMY Transcriptional regulator BF35_5060 ENOG4105HDK L-asparaginase BF35_5061 ENOG4108IJ0 Aspartate ammonia-lyase BF35_5063 ENOG4105E2A Dehydrogenase BF35_507 ENOG4108YV3 Protein of unknown function (DUF2711) BF35_5076 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF35_5082 ENOG4105DWD nucleoside recognition domain protein BF35_5086 ENOG4105FDT acyl-CoA dehydrogenase BF35_5088 ENOG4108ZHR arsR family transcriptional regulator BF35_5089 ENOG4108ZRV stage ii sporulation protein p BF35_5090 ENOG4106N3A copper homeostasis protein cutc BF35_5092 ENOG4107258 Transcriptional regulator BF35_5093 ENOG4105P4J Allophanate hydrolase, subunit 1 BF35_5099 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BF35_5101 ENOG4107RF6 penicillin-binding protein BF35_5109 ENOG4105F1N DNA alkylation repair BF35_5111 ENOG4108IQI permease BF35_5113 ENOG410635A Membrane BF35_5124 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BF35_5129 ENOG4108XET gCN5-related N-acetyltransferase BF35_5130 ENOG4108DMH HTH_ARAC BF35_5135 ENOG4105C19 ABC transporter BF35_5137 ENOG4105WEC Molybdate metabolism regulator BF35_5138 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BF35_5142 ENOG4105FS7 Transcriptional regulator BF35_5143 ENOG4108TVJ Nitroreductase BF35_5147 ENOG4105CHH sulfate transporter BF35_5148 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BF35_5150 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF35_5158 ENOG4105C8Y Acetylornithine aminotransferase BF35_5160 ENOG4105CKK Glycosyl transferase, family 2 BF35_5163 ENOG4105CKK Glycosyl transferase, family 2 BF35_5168 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF35_517 ENOG4105WH1 Two component transcriptional regulator luxr family BF35_5174 ENOG4105KNA -acetyltransferase BF35_5177 ENOG4108NEV two component transcriptional regulator, LytTR family BF35_5179 ENOG41090T1 Membrane BF35_518 ENOG4105BZU Histidine kinase BF35_5182 ENOG4105VMP Transcriptional regulator BF35_5184 ENOG4105G6Z alkaline phosphatase BF35_5186 ENOG4105ECK Fatty Acid Desaturase BF35_5187 ENOG4105E0Y RtcB Protein BF35_5189 ENOG4107258 Transcriptional regulator BF35_519 ENOG4105D8X mechanosensitive ion channel BF35_5191 ENOG4105II7 pyrroline-5-carboxylate reductase BF35_5198 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BF35_5203 ENOG41061GT Aldolase BF35_5205 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BF35_5206 ENOG4105DKT Transcriptional regulator BF35_5208 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BF35_5209 ENOG4105F5R ABC transporter BF35_521 ENOG4105E09 nadh pyrophosphatase BF35_5210 ENOG4105D4B ABC, transporter BF35_5216 ENOG41069ER domain protein BF35_5221 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF35_5223 ENOG4105CIH Imidazole acetol-phosphate transaminase BF35_5227 ENOG41082JN Transcriptional regulator BF35_5228 ENOG4105EYF MMPL domain protein BF35_5230 ENOG4105C5H ABC transporter BF35_5231 ENOG4105E0M Sulfatase BF35_5232 ENOG4108ZCF integral membrane protein BF35_5233 ENOG4106ETB IIa component BF35_5235 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC BF35_5237 ENOG4107VMI polysaccharide deacetylase BF35_5238 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BF35_5249 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BF35_525 ENOG4105F0I Aminotransferase BF35_5253 ENOG4105E09 nadh pyrophosphatase BF35_5256 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BF35_5257 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BF35_5258 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BF35_526 ENOG4108MES Periplasmic binding protein BF35_5260 ENOG4105C02 permease BF35_5269 ENOG4105DVE abc transporter atp-binding protein BF35_5272 ENOG4108ZMI UPF0477 protein BF35_5275 ENOG4105CHM Aminotransferase BF35_5282 ENOG41089UC methyltransferase, type 11 BF35_5285 ENOG4107BMA Transglycosylase associated protein BF35_5289 ENOG4106K7D Major facilitator family transporter BF35_5290 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF35_530 ENOG4105CAQ asparagine synthetase BF35_5303 ENOG4105EPR degv family BF35_5304 ENOG4105DPN Oligoendopeptidase f BF35_531 ENOG4107Y70 Heat shock protein BF35_5312 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF35_5313 ENOG4105BZU Histidine kinase BF35_5314 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BF35_532 ENOG4108KF3 Electron transport protein SCO1 SenC BF35_5323 ENOG4105DTQ mandelate racemase muconate lactonizing BF35_5329 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF35_533 ENOG4105E8R UPF0173 metal-dependent hydrolase BF35_5332 ENOG4107T5V SNARE associated Golgi BF35_534 ENOG4108RCR degv family BF35_5341 ENOG41080HI glycine oxidase BF35_5342 ENOG4105CTU Proline racemase BF35_5343 ENOG4105CTU Proline racemase BF35_5344 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF35_5345 ENOG4105C26 Dehydrogenase BF35_5346 ENOG4105BZG amino acid carrier protein BF35_5350 ENOG4108M1A Chitin-binding protein BF35_536 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BF35_5360 ENOG4105C9U ATP-dependent DNA helicase RecQ BF35_5364 ENOG4105EEM helicase BF35_5368 ENOG4108Z7F N-acetyltransferase BF35_5373 ENOG4105IYK transposase BF35_5374 ENOG4105DQ6 Transposase BF35_5376 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF35_5378 ENOG4105MSB protein, conserved in bacteria BF35_5379 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF35_538 ENOG4108UT2 hemolysin iii BF35_5384 ENOG41087PP glycosyltransferase MGT family BF35_5385 ENOG4108M1A Chitin-binding protein BF35_5386 ENOG41082BV acetyltransferase BF35_539 ENOG4105E9Q Acyl-transferase BF35_5392 ENOG4108IJ7 Glycine betaine BF35_5394 ENOG4107SQ8 Glycine betaine BF35_5401 ENOG4105RHY Pfam:UPF0157 BF35_5402 ENOG4105E1F short-chain dehydrogenase reductase BF35_5404 ENOG4107RUY (E1 component), alpha subunit BF35_5406 ENOG4107QKR Dehydrogenase BF35_541 ENOG4107RVG penicillin-binding protein BF35_5411 ENOG4105E98 transcriptional regulator DeoR family BF35_5415 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BF35_5419 ENOG4107Z3H Transcriptional regulator, TetR family BF35_5427 ENOG4105MSI germination protein ypeb BF35_5437 ENOG4108JJA ABC, transporter BF35_5447 ENOG41067QW Transcriptional regulator BF35_545 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BF35_5451 ENOG4107QJE Chromosome Partitioning Protein BF35_5454 ENOG4105C19 ABC transporter BF35_549 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BF35_554 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BF35_555 ENOG4105KD7 acetyltransferase BF35_558 ENOG4105C0A alcohol dehydrogenase BF35_559 ENOG4105CY2 Citrate transporter BF35_560 ENOG4107XGZ Hydrolase BF35_564 ENOG4105C8J )-transporter BF35_578 ENOG4105EC2 ftsk spoIIIe BF35_58 ENOG4107Y9U Membrane BF35_582 ENOG4105C5S asparaginyl-tRNA synthetase BF35_593 ENOG4107YX5 Pfam:DUF548 BF35_597 ENOG4108UUM single-stranded DNA-binding protein BF35_600 ENOG4105C5H ABC transporter BF35_604 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF35_607 ENOG4105MCT stage V sporulation protein S BF35_612 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF35_613 ENOG4108IFG nitrite reductase, (NAD(P)H) BF35_614 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BF35_615 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF35_616 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF35_617 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF35_62 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF35_623 ENOG4108ZAF Molybdopterin BF35_624 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF35_625 ENOG4105D06 uba thif-type nad fad binding protein BF35_626 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF35_627 ENOG4107V6Q Cyclic nucleotide-binding domain BF35_629 ENOG4105R3A Nitrate reductase BF35_630 ENOG4108IUE nitrate reductase beta subunit BF35_634 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF35_638 ENOG4108V06 Glutathione peroxidase BF35_640 ENOG4105CNW domain protein BF35_644 ENOG4105EMN RNA polymerase sigma factor BF35_645 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BF35_647 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BF35_652 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF35_657 ENOG4105KBJ sporulation protein ytfj BF35_66 ENOG4107Y80 Major Facilitator superfamily BF35_665 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF35_671 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF35_672 ENOG4108JYZ YitT family BF35_673 ENOG41087PP glycosyltransferase MGT family BF35_676 ENOG4107RBS Methyltransferase BF35_677 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF35_679 ENOG4108X4Q Hydrolase BF35_68 ENOG4108V4B ThiJ pfpI BF35_681 ENOG41069HH 4-oxalocrotonate tautomerase BF35_687 ENOG4105KME endoribonuclease L-psp BF35_690 ENOG4105U1N riboflavin BF35_692 ENOG4105EFA 4-hydroxyphenylacetate BF35_696 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF35_697 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BF35_698 ENOG4108VXD carboxy-peptidase BF35_7 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF35_700 ENOG4108ZRV stage ii sporulation protein p BF35_703 ENOG4108Z7R Chaperone CsaA BF35_705 ENOG4105DQ6 Transposase BF35_706 ENOG4105IYK transposase BF35_709 ENOG4105C37 (CBS) domain BF35_710 ENOG4105SXS Protein of unknown function (DUF456) BF35_714 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF35_715 ENOG4108S4H thioesterase Superfamily protein BF35_717 ENOG4108PJD permease BF35_720 ENOG4107T5V SNARE associated Golgi BF35_724 ENOG4105CVJ phosphoglycerate mutase BF35_729 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF35_731 ENOG4105K4T epimerase BF35_733 ENOG4105DSE periplasmic solute binding protein BF35_735 ENOG4105CKI cobalamin synthesis protein BF35_736 ENOG4107QM2 Aldo Keto reductase BF35_737 ENOG4105VMI -acetyltransferase BF35_740 ENOG4105DEN Luciferase family BF35_743 ENOG4108WPJ Ferritin-like domain BF35_744 ENOG4108K88 Membrane BF35_751 ENOG4107XZQ multidrug resistance protein BF35_752 ENOG4105CPC Aldo Keto reductase BF35_753 ENOG4105YVS arsR family transcriptional regulator BF35_754 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase BF35_756 ENOG4105KRN Transcriptional regulator, abrb family BF35_766 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF35_767 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF35_769 ENOG4105YWU small acid-soluble spore protein BF35_77 ENOG4105CHR reductase BF35_770 ENOG4108WBH protein TIM barrel BF35_773 ENOG4105CEY Amp-dependent synthetase and ligase BF35_774 ENOG4105DUU IucA IucC family protein BF35_776 ENOG4105VRR gCN5-related N-acetyltransferase BF35_777 ENOG4105KT7 mgtC SapB transporter BF35_779 ENOG4107VMI polysaccharide deacetylase BF35_78 ENOG4108IG5 Transcriptional regulator BF35_780 ENOG4105BZU Histidine kinase BF35_781 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF35_783 ENOG4108KGH TRANSCRIPTIONal BF35_788 ENOG4105D6E homoserine dehydrogenase BF35_79 ENOG4105CJN penicillin-binding protein BF35_792 ENOG4108ZJ4 polysaccharide deacetylase BF35_793 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BF35_797 ENOG4105BZU Histidine kinase BF35_798 ENOG4105EFI regulatoR BF35_799 ENOG4105BZ1 (ABC) transporter BF35_80 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF35_808 ENOG4108UT6 Transferase hexapeptide repeat containing protein BF35_81 ENOG4105CB2 alcohol dehydrogenase BF35_810 ENOG4105K64 Glycosyl transferase, family 2 BF35_812 ENOG4108JJ8 (ABC) transporter BF35_813 ENOG4108JJ9 ABC, transporter BF35_814 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF35_815 ENOG4105C4M (Ubiquinol oxidase) subunit I BF35_819 ENOG4105MDS 4-oxalocrotonate tautomerase BF35_82 ENOG4105RHY Pfam:UPF0157 BF35_821 ENOG4105SKE transcriptional Regulator LysR family BF35_823 ENOG4105C32 Amino acid ABC transporter (Permease) BF35_824 ENOG4108IV0 ABC, transporter BF35_825 ENOG4105C0Z ABC transporter BF35_828 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF35_829 ENOG4108Z7G MaoC domain protein dehydratase BF35_832 ENOG4105CKI cobalamin synthesis protein BF35_834 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF35_835 ENOG4106F5Q Membrane BF35_838 ENOG4108TVJ Nitroreductase BF35_839 ENOG4107ZXU DSBA oxidoreductase BF35_84 ENOG4108HGU Histidine kinase BF35_840 ENOG4108Z40 Transcriptional regulator BF35_841 ENOG4105GZI Transcriptional regulator BF35_842 ENOG4107RT3 EamA-like transporter family BF35_843 ENOG4105KTB nuclear export factor GLE1 BF35_844 ENOG4108T5E Copper resistance protein BF35_853 ENOG4107R16 Multicopper oxidase BF35_854 ENOG4107RAQ aminopeptidase BF35_859 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BF35_860 ENOG4105D9N nucleoside BF35_862 ENOG4107RHR regulatoR BF35_870 ENOG4105C0X amino acid BF35_872 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BF35_875 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BF35_880 ENOG41068WN BF35_892 ENOG4105CYC Transferase BF35_893 ENOG4105DY9 regulatoR BF35_896 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BF35_897 ENOG4105C6X Major Facilitator BF35_9 ENOG4108IUM Glycogen debranching enzyme BF35_902 ENOG4105C7B Threonine dehydratase BF35_906 ENOG4105C7K acetolactate synthase BF35_907 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF35_908 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF35_91 ENOG4105BZU Histidine kinase BF35_912 ENOG4105H67 Protein of unknown function (DUF421) BF35_913 ENOG4105X5K response regulator receiver protein BF35_915 ENOG4105C8J )-transporter BF35_919 ENOG4105C6T cysteine synthase BF35_92 ENOG410667J hydrolase BF35_920 ENOG4105EU0 Major facilitator Superfamily BF35_922 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF35_925 ENOG4105DXI Major Facilitator superfamily BF35_929 ENOG4105CSR polyphosphate kinase 2 BF35_935 ENOG4105FVX BF35_940 ENOG41067QW Transcriptional regulator BF35_946 ENOG4105C6K Malic enzyme BF35_947 ENOG4108IJ0 Aspartate ammonia-lyase BF35_949 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BF35_953 ENOG4105CJ1 ABC, transporter BF35_960 ENOG4106BRA Membrane BF35_965 ENOG4107QIV Cytochrome c biogenesis protein BF35_969 ENOG4105EC3 peptidase S51, dipeptidase E BF35_970 ENOG4107QJQ Mate efflux family protein BF35_972 ENOG4105C5X domain protein BF35_974 ENOG4105C9Q fumarate hydratase class II BF35_975 ENOG4105EMU Dehydrogenase BF35_976 ENOG4105VUF Transcriptional regulator BF35_977 ENOG4105DFD Na H antiporter BF35_980 ENOG4108PJD permease BF35_981 ENOG4105CKI cobalamin synthesis protein BF35_982 ENOG4108UZ3 Transporter BF35_983 ENOG4105DRR Transcriptional regulator, GntR family BF35_985 ENOG4105PGM cation diffusion facilitator family transporter BF35_989 ENOG4105CAQ asparagine synthetase BF35_991 ENOG4105K56 Transcriptional regulator