locus-tag	class	description
BF35_1003	COG1177	transmembrane transport
BF35_1004	COG0725	ABC transporter, periplasmic molybdate-binding protein
BF35_1005	COG3842	ATPase activity
BF35_1012	COG3764	Sortase (surface protein transpeptidase)
BF35_1013	COG3764	Sortase (surface protein transpeptidase)
BF35_1019	COG2329	Antibiotic biosynthesis monooxygenase
BF35_1025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BF35_1026	COG4786	Flagellar basal body rod
BF35_1027	COG1419	protein localization to endoplasmic reticulum
BF35_1028	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BF35_1029	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BF35_1031	COG1987	bacterial-type flagellum assembly
BF35_1032	COG1338	Plays a role in the flagellum-specific transport system
BF35_1034	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BF35_1034	COG1776	CheC inhibitor of MCP methylation
BF35_1035	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BF35_1037	COG0741	lytic transglycosylase activity
BF35_1038	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BF35_1041	COG0784	Response regulator, receiver
BF35_1041	COG0835	chemotaxis
BF35_1048	COG1157	protein secretion by the type III secretion system
BF35_1050	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BF35_1051	COG1766	The M ring may be actively involved in energy transduction
BF35_1052	COG1677	Flagellar hook-basal body complex protein FliE
BF35_1053	COG1558	bacterial-type flagellum-dependent cell motility
BF35_1054	COG1815	bacterial-type flagellum-dependent cell motility
BF35_1057	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BF35_1058	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BF35_1059	COG1256	bacterial-type flagellum assembly
BF35_1063	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BF35_1066	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BF35_1066	COG1776	CheC inhibitor of MCP methylation
BF35_1067	COG0643	Histidine kinase
BF35_1067	COG2198	Histidine kinase
BF35_1068	COG2201	protein-glutamate methylesterase activity
BF35_1069	COG1360	Flagellar Motor Protein
BF35_1070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BF35_1072	COG1923	regulation of RNA biosynthetic process
BF35_1076	COG2814	Major facilitator Superfamily
BF35_108	COG5632	N-Acetylmuramoyl-L-alanine amidase
BF35_1083	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BF35_1084	COG2323	membrane
BF35_1086	COG4978	Transcriptional regulator
BF35_1086	COG0789	Transcriptional regulator
BF35_1087	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BF35_1088	COG0475	glutathione-regulated potassium exporter activity
BF35_1090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BF35_1091	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BF35_1092	COG3162	membrane
BF35_1095	COG1280	lysine exporter protein (LysE YggA)
BF35_1096	COG3403	YqcI/YcgG family
BF35_1103	COG0328	RNA-DNA hybrid ribonuclease activity
BF35_1107	COG0454	-acetyltransferase
BF35_1110	COG0438	transferase activity, transferring glycosyl groups
BF35_1111	COG1215	transferase activity, transferring glycosyl groups
BF35_1114	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BF35_1119	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BF35_1122	COG0754	glutathionylspermidine amidase activity
BF35_1127	COG0456	acetyltransferase
BF35_1129	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BF35_1131	COG2311	Membrane
BF35_1132	COG2233	PERMEase
BF35_1134	COG0024	Methionine aminopeptidase
BF35_1136	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BF35_1137	COG1199	ATP-dependent helicase activity
BF35_1139	COG0116	Belongs to the methyltransferase superfamily
BF35_1152	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BF35_1153	COG3935	DnaD domain protein
BF35_1157	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BF35_1157	COG1199	ATP-dependent helicase activity
BF35_1164	COG0438	transferase activity, transferring glycosyl groups
BF35_1165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BF35_1168	COG1694	Mazg nucleotide pyrophosphohydrolase
BF35_1169	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF35_1171	COG2738	Putative neutral zinc metallopeptidase
BF35_1174	COG4347	Protein of unknown function (DUF1405)
BF35_1175	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BF35_1175	COG2010	Cytochrome c
BF35_1176	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BF35_1180	COG0457	Tetratricopeptide repeat
BF35_1185	COG0142	geranyltranstransferase activity
BF35_1187	COG0142	geranyltranstransferase activity
BF35_1190	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BF35_1204	COG0252	asparaginase activity
BF35_1205	COG0492	ferredoxin-NADP+ reductase activity
BF35_1208	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BF35_1209	COG4862	establishment of competence for transformation
BF35_121	COG0740	serine-type endopeptidase activity
BF35_1211	COG1408	metallophosphoesterase
BF35_1213	COG1266	CAAX protease self-immunity
BF35_1214	COG0514	ATP-dependent DNA helicase (RecQ)
BF35_1216	COG1141	Ferredoxin
BF35_1217	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BF35_1219	COG4942	peptidase
BF35_1220	COG2096	Adenosyltransferase
BF35_1221	COG5002	protein histidine kinase activity
BF35_1222	COG0745	RESPONSE REGULATOR receiver
BF35_1223	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BF35_1224	COG1333	cytochrome c biogenesis protein
BF35_1226	COG1187	pseudouridine synthase activity
BF35_1227	COG0700	Nucleoside recognition
BF35_1228	COG2715	membrane protein required for spore maturation
BF35_1229	COG1686	Belongs to the peptidase S11 family
BF35_1230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BF35_1233	COG0392	lysyltransferase activity
BF35_1233	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BF35_1236	COG5002	protein histidine kinase activity
BF35_1237	COG0582	viral genome integration into host DNA
BF35_1239	COG1801	Protein of unknown function DUF72
BF35_124	COG4626	Terminase
BF35_124	COG1802	Transcriptional regulator
BF35_1240	COG3852	Histidine kinase
BF35_1243	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BF35_1244	COG1392	Phosphate transport regulator
BF35_1245	COG0306	phosphate transporter
BF35_1246	COG0730	response to heat
BF35_1256	COG1114	Component of the transport system for branched-chain amino acids
BF35_1258	COG2197	response regulator
BF35_1259	COG4585	Histidine kinase
BF35_1260	COG4758	membrane
BF35_1263	COG1757	Na H antiporter
BF35_1267	COG0733	neurotransmitter:sodium symporter activity
BF35_1268	COG1648	precorrin-2 dehydrogenase activity
BF35_1272	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BF35_1273	COG0529	Catalyzes the synthesis of activated sulfate
BF35_1277	COG0019	diaminopimelate decarboxylase activity
BF35_1279	COG1368	sulfuric ester hydrolase activity
BF35_1280	COG1183	phosphatidylcholine synthase activity
BF35_1283	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BF35_1298	COG0440	acetolactate synthase activity
BF35_1299	COG0028	Belongs to the TPP enzyme family
BF35_1300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BF35_1304	COG3874	Sporulation protein YtfJ
BF35_1305	COG4709	membrane
BF35_1306	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BF35_1307	COG1301	dicarboxylic acid transport
BF35_1309	COG1846	Transcriptional regulator
BF35_1313	COG0534	Mate efflux family protein
BF35_1320	COG0716	FMN binding
BF35_1325	COG1696	Membrane protein involved in D-alanine export
BF35_1327	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BF35_1328	COG2070	2-Nitropropane dioxygenase
BF35_1329	COG1619	proteins homologs of microcin C7 resistance protein MccF
BF35_1331	COG1335	isochorismatase
BF35_1333	COG1522	sequence-specific DNA binding
BF35_1335	COG1266	CAAX protease self-immunity
BF35_1336	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BF35_1337	COG1131	(ABC) transporter
BF35_1339	COG1131	(ABC) transporter
BF35_134	COG1404	Belongs to the peptidase S8 family
BF35_1340	COG1725	Transcriptional regulator
BF35_1341	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BF35_1342	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BF35_1343	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BF35_1344	COG1780	Probably involved in ribonucleotide reductase function
BF35_1350	COG4873	Protein conserved in bacteria
BF35_1353	COG0720	synthase
BF35_1355	COG5002	protein histidine kinase activity
BF35_1357	COG2318	DinB family
BF35_1359	COG1846	Transcriptional regulator
BF35_1360	COG3852	Histidine kinase
BF35_1362	COG2861	carbohydrate metabolic process
BF35_1364	COG0235	Class ii aldolase
BF35_1367	COG1349	DNA-binding transcription factor activity
BF35_137	COG0582	viral genome integration into host DNA
BF35_1372	COG3842	ATPase activity
BF35_1373	COG1840	ABC-type Fe3 transport system, periplasmic component
BF35_1376	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BF35_1378	COG3243	poly(R)-hydroxyalkanoic acid synthase
BF35_1379	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_1383	COG2030	dehydratase
BF35_1385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BF35_1386	COG0861	Integral membrane protein TerC family
BF35_1387	COG2116	formate transmembrane transporter activity
BF35_1389	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BF35_1393	COG2186	Transcriptional regulator
BF35_1394	COG2186	Transcriptional regulator
BF35_1395	COG5002	protein histidine kinase activity
BF35_1396	COG0745	RESPONSE REGULATOR receiver
BF35_1398	COG3835	regulator
BF35_1399	COG0277	FAD linked oxidase domain protein
BF35_1400	COG0247	lactate metabolic process
BF35_1401	COG2340	Cysteine-rich secretory protein family
BF35_1403	COG0564	pseudouridine synthase activity
BF35_1405	COG2409	Drug exporters of the RND superfamily
BF35_1407	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BF35_1408	COG1177	transmembrane transport
BF35_1409	COG1176	ABC-type spermidine putrescine transport system, permease component I
BF35_1411	COG1012	belongs to the aldehyde dehydrogenase family
BF35_1419	COG0681	Belongs to the peptidase S26 family
BF35_1420	COG1686	Belongs to the peptidase S11 family
BF35_1422	COG2226	methyltransferase
BF35_1436	COG1476	TRANSCRIPTIONal
BF35_1438	COG0508	dehydrogenase complex catalyzes the overall conversion of
BF35_1450	COG5634	Uncharacterized conserved protein (DUF2278)
BF35_1451	COG1620	l-lactate permease
BF35_1458	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BF35_1458	COG0512	Glutamine amidotransferase of anthranilate synthase
BF35_1460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BF35_1461	COG5492	domain, Protein
BF35_1465	COG2382	esterase
BF35_1467	COG2153	protein acetylation
BF35_1475	COG1091	dTDP-4-dehydrorhamnose reductase activity
BF35_1478	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BF35_148	COG2002	toxin-antitoxin pair type II binding
BF35_1482	COG0463	Glycosyl transferase, family 2
BF35_1482	COG0457	Tetratricopeptide repeat
BF35_1486	COG1216	Glycosyl transferase, family 2
BF35_1487	COG0772	Belongs to the SEDS family
BF35_1490	COG0564	pseudouridine synthase activity
BF35_1492	COG2357	RelA SpoT domain protein
BF35_1494	COG4116	CYTH
BF35_1495	COG2346	COG2346, Truncated hemoglobins
BF35_1498	COG1164	Oligoendopeptidase f
BF35_150	COG1484	DNA-dependent DNA replication
BF35_1500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BF35_1501	COG4862	establishment of competence for transformation
BF35_1502	COG0861	Integral membrane protein TerC family
BF35_1503	COG1393	Belongs to the ArsC family
BF35_1505	COG4166	transmembrane transport
BF35_1506	COG0534	Mate efflux family protein
BF35_1507	COG4608	Belongs to the ABC transporter superfamily
BF35_1508	COG0444	Belongs to the ABC transporter superfamily
BF35_1509	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BF35_1510	COG0601	transmembrane transport
BF35_1511	COG4166	transmembrane transport
BF35_1513	COG0180	Tryptophanyl-tRNA synthetase
BF35_1515	COG5504	Zn-dependent protease
BF35_1516	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BF35_1517	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF35_1520	COG2267	carboxylic ester hydrolase activity
BF35_1524	COG0561	phosphatase activity
BF35_1527	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF35_1529	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BF35_1530	COG2996	Protein conserved in bacteria
BF35_1534	COG0004	ammonium transporteR
BF35_1535	COG0753	catalase activity
BF35_1537	COG0367	asparagine synthase
BF35_1542	COG0179	Fumarylacetoacetate (FAA) hydrolase
BF35_1558	COG0398	Pfam SNARE associated Golgi protein
BF35_1560	COG4903	ComK protein
BF35_1563	COG1278	Cold shock
BF35_1565	COG2224	Isocitrate lyase
BF35_1566	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BF35_1567	COG0497	DNA recombination
BF35_1570	COG0697	spore germination
BF35_1571	COG0840	transmembrane signaling receptor activity
BF35_1572	COG0501	Belongs to the peptidase M48B family
BF35_1577	COG0745	RESPONSE REGULATOR receiver
BF35_1578	COG2205	protein histidine kinase activity
BF35_1580	COG3708	Transcriptional regulator
BF35_1580	COG2207	Transcriptional regulator
BF35_1581	COG1595	DNA-templated transcription, initiation
BF35_1583	COG1078	dGTPase activity
BF35_1584	COG1408	metallophosphoesterase
BF35_1585	COG1073	alpha beta
BF35_1586	COG1309	transcriptional regulator
BF35_1590	COG3209	COG3209 Rhs family protein
BF35_1593	COG0318	PFAM AMP-dependent synthetase and ligase
BF35_1595	COG0095	Lipoate-protein ligase
BF35_1596	COG1234	tRNA 3'-trailer cleavage
BF35_1598	COG1609	Transcriptional regulator
BF35_1599	COG2378	regulation of single-species biofilm formation
BF35_160	COG0582	viral genome integration into host DNA
BF35_1604	COG1511	domain protein
BF35_1605	COG1309	transcriptional regulator
BF35_1613	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BF35_1614	COG2329	Antibiotic biosynthesis monooxygenase
BF35_1615	COG3428	Bacterial PH domain
BF35_1616	COG3402	PFAM membrane-flanked domain
BF35_1623	COG3428	Bacterial PH domain
BF35_1624	COG3402	PFAM membrane-flanked domain
BF35_1626	COG1309	transcriptional regulator
BF35_1629	COG4473	ABC transporter
BF35_1630	COG1131	(ABC) transporter
BF35_1631	COG0537	adenosine 5'-monophosphoramidase activity
BF35_1632	COG4980	gas vesicle protein
BF35_1636	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BF35_1637	COG3973	AAA domain
BF35_164	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BF35_1641	COG1595	DNA-templated transcription, initiation
BF35_1646	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BF35_1648	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BF35_1649	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BF35_1653	COG2267	carboxylic ester hydrolase activity
BF35_1655	COG0346	lactoylglutathione lyase activity
BF35_1656	COG0346	lactoylglutathione lyase activity
BF35_166	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF35_1660	COG0457	Tetratricopeptide repeat
BF35_1664	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BF35_1666	COG4717	serine-type aminopeptidase activity
BF35_1667	COG0420	3'-5' exonuclease activity
BF35_167	COG0460	homoserine dehydrogenase
BF35_1672	COG2197	response regulator
BF35_1673	COG4585	Histidine kinase
BF35_1678	COG0393	Putative heavy-metal-binding
BF35_1683	COG0784	Response regulator, receiver
BF35_1683	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF35_1683	COG2198	Histidine kinase
BF35_1683	COG2205	protein histidine kinase activity
BF35_1684	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BF35_1685	COG2208	phosphoserine phosphatase activity
BF35_1687	COG1191	sigma factor activity
BF35_1702	COG3437	response regulator, receiver
BF35_1702	COG2770	Histidine kinase
BF35_1705	COG0457	Tetratricopeptide repeat
BF35_1707	COG1959	2 iron, 2 sulfur cluster binding
BF35_1709	COG2376	Dihydroxyacetone kinase
BF35_171	COG0577	efflux transmembrane transporter activity
BF35_1711	COG2376	Dihydroxyacetone kinase
BF35_1715	COG1183	phosphatidylcholine synthase activity
BF35_172	COG1136	(ABC) transporter
BF35_1728	COG0477	Major facilitator Superfamily
BF35_1734	COG0305	Participates in initiation and elongation during chromosome replication
BF35_1738	COG0789	Transcriptional regulator
BF35_1738	COG4978	Transcriptional regulator
BF35_1741	COG1061	Type III restriction enzyme res subunit
BF35_1744	COG0494	nUDIX hydrolase
BF35_1745	COG3181	Tripartite tricarboxylate transporter family receptor
BF35_1746	COG4565	transcriptional regulatory protein
BF35_1747	COG3290	protein histidine kinase activity
BF35_1748	COG0477	Major facilitator Superfamily
BF35_1759	COG1363	Peptidase, m42
BF35_1763	COG1024	Enoyl-CoA hydratase
BF35_1767	COG4196	transglutaminase domain protein
BF35_1769	COG2244	polysaccharide biosynthetic process
BF35_177	COG2205	protein histidine kinase activity
BF35_1770	COG0653	protein targeting
BF35_1773	COG0659	secondary active sulfate transmembrane transporter activity
BF35_1778	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BF35_1779	COG3409	Peptidoglycan-binding domain 1 protein
BF35_1779	COG5632	N-Acetylmuramoyl-L-alanine amidase
BF35_178	COG0745	RESPONSE REGULATOR receiver
BF35_1781	COG0561	phosphatase activity
BF35_1783	COG3527	Alpha-acetolactate decarboxylase
BF35_1784	COG0028	Belongs to the TPP enzyme family
BF35_1790	COG0189	ligase activity
BF35_1793	COG1126	abc transporter atp-binding protein
BF35_1794	COG0765	amino acid transport
BF35_1795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF35_1796	COG1132	(ABC) transporter
BF35_1797	COG1132	(ABC) transporter
BF35_1798	COG1012	belongs to the aldehyde dehydrogenase family
BF35_18	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BF35_180	COG3773	Cell wall hydrolase
BF35_1800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BF35_1801	COG0531	amino acid
BF35_1804	COG0693	protein deglycase activity
BF35_1806	COG2211	Major facilitator Superfamily
BF35_1807	COG4533	DNA binding
BF35_1811	COG1733	regulation of RNA biosynthetic process
BF35_1812	COG2814	Major facilitator Superfamily
BF35_1813	COG1309	transcriptional regulator
BF35_1814	COG2076	Multidrug Resistance protein
BF35_1815	COG2076	Multidrug Resistance protein
BF35_1817	COG1522	sequence-specific DNA binding
BF35_182	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
BF35_1821	COG2259	Doxx family
BF35_1823	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BF35_1823	COG1263	PTS System
BF35_1825	COG1737	Transcriptional regulator
BF35_1827	COG0475	glutathione-regulated potassium exporter activity
BF35_1828	COG0531	amino acid
BF35_1835	COG0586	Pfam SNARE associated Golgi protein
BF35_184	COG3386	PFAM SMP-30 Gluconolaconase
BF35_1842	COG3546	catalase activity
BF35_1843	COG1114	Component of the transport system for branched-chain amino acids
BF35_1846	COG5522	Integral membrane protein (intg_mem_TP0381)
BF35_1848	COG1136	(ABC) transporter
BF35_1849	COG0577	efflux transmembrane transporter activity
BF35_1853	COG0640	Transcriptional regulator
BF35_1855	COG0667	Aldo Keto reductase
BF35_1856	COG2814	Major facilitator Superfamily
BF35_1857	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BF35_1857	COG1605	Chorismate mutase
BF35_1858	COG2814	Major facilitator Superfamily
BF35_186	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BF35_1864	COG3584	3D domain protein
BF35_1864	COG1388	LysM domain
BF35_1868	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BF35_1869	COG1447	Phosphotransferase system cellobiose-specific component IIA
BF35_1870	COG3711	transcriptional antiterminator
BF35_1870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BF35_1872	COG2814	Major facilitator Superfamily
BF35_1873	COG1283	sodium-dependent phosphate transmembrane transporter activity
BF35_1874	COG0604	alcohol dehydrogenase
BF35_1875	COG1316	TRANSCRIPTIONal
BF35_1877	COG0730	response to heat
BF35_1878	COG2210	Belongs to the sulfur carrier protein TusA family
BF35_188	COG2323	membrane
BF35_1880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BF35_1880	COG0425	Belongs to the sulfur carrier protein TusA family
BF35_1882	COG0425	Belongs to the sulfur carrier protein TusA family
BF35_1883	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BF35_1883	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF35_1884	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BF35_1884	COG0425	Belongs to the sulfur carrier protein TusA family
BF35_1885	COG1937	Protein conserved in bacteria
BF35_1886	COG0446	pyridine nucleotide-disulphide oxidoreductase
BF35_1891	COG2719	SpoVR family
BF35_1892	COG0778	Nitroreductase
BF35_1900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF35_1902	COG1609	Transcriptional regulator
BF35_1903	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BF35_1903	COG1263	PTS System
BF35_1904	COG1621	beta-fructofuranosidase activity
BF35_1905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BF35_1908	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_1909	COG2252	PERMEase
BF35_1912	COG1846	Transcriptional regulator
BF35_1913	COG2814	Major facilitator Superfamily
BF35_1914	COG2205	protein histidine kinase activity
BF35_192	COG2368	4-hydroxyphenylacetate
BF35_1921	COG0351	phosphomethylpyrimidine kinase
BF35_1922	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BF35_1924	COG2104	thiamine diphosphate biosynthetic process
BF35_1925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BF35_1926	COG0352	thiamine-phosphate diphosphorylase activity
BF35_1927	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BF35_1928	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BF35_1929	COG1116	anion transmembrane transporter activity
BF35_193	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF35_1930	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BF35_1935	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BF35_1959	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BF35_1961	COG0581	inorganic phosphate transmembrane transporter activity
BF35_1962	COG0573	inorganic phosphate transmembrane transporter activity
BF35_1963	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BF35_1964	COG1918	ferrous iron import across plasma membrane
BF35_1964	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BF35_1965	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BF35_1966	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BF35_1968	COG0531	amino acid
BF35_1969	COG0697	spore germination
BF35_1970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BF35_1973	COG4990	cell redox homeostasis
BF35_1974	COG0833	amino acid
BF35_1975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BF35_1976	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BF35_1979	COG0569	domain protein
BF35_1979	COG0475	glutathione-regulated potassium exporter activity
BF35_1980	COG2153	protein acetylation
BF35_1983	COG2252	PERMEase
BF35_1984	COG1113	amino acid transport
BF35_1987	COG1114	Component of the transport system for branched-chain amino acids
BF35_1988	COG3104	oligopeptide transport
BF35_1991	COG1476	TRANSCRIPTIONal
BF35_1992	COG3583	domain protein
BF35_1992	COG3584	3D domain protein
BF35_1993	COG0840	transmembrane signaling receptor activity
BF35_1999	COG3568	Endonuclease Exonuclease Phosphatase
BF35_2002	COG1063	alcohol dehydrogenase
BF35_2005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BF35_2006	COG1879	ABC-type sugar transport system periplasmic component
BF35_2007	COG1172	Belongs to the binding-protein-dependent transport system permease family
BF35_2008	COG1129	ABC transporter
BF35_201	COG2226	methyltransferase
BF35_2010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BF35_2011	COG1609	Transcriptional regulator
BF35_2012	COG0477	Major facilitator Superfamily
BF35_2013	COG1846	Transcriptional regulator
BF35_2014	COG2271	Major facilitator Superfamily
BF35_2016	COG4608	Belongs to the ABC transporter superfamily
BF35_2017	COG0601	transmembrane transport
BF35_202	COG1733	regulation of RNA biosynthetic process
BF35_2022	COG0659	secondary active sulfate transmembrane transporter activity
BF35_2025	COG5002	protein histidine kinase activity
BF35_2026	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BF35_2027	COG2378	regulation of single-species biofilm formation
BF35_2029	COG1595	DNA-templated transcription, initiation
BF35_203	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_2032	COG0833	amino acid
BF35_2033	COG0765	amino acid transport
BF35_2034	COG0765	amino acid transport
BF35_2035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF35_2036	COG1126	abc transporter atp-binding protein
BF35_2037	COG1115	amino acid carrier protein
BF35_2038	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BF35_2040	COG0697	spore germination
BF35_2044	COG0366	Alpha amylase catalytic
BF35_2045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BF35_2045	COG1263	PTS System
BF35_2046	COG2188	Transcriptional regulator
BF35_2047	COG0531	amino acid
BF35_205	COG2814	Major facilitator Superfamily
BF35_2051	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BF35_2052	COG0714	Associated with various cellular activities
BF35_2056	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF35_2057	COG0156	8-amino-7-oxononanoate synthase activity
BF35_2058	COG2226	methyltransferase
BF35_2060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF35_2061	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF35_2062	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF35_2063	COG3104	oligopeptide transport
BF35_2066	COG1620	l-lactate permease
BF35_2067	COG1027	Aspartate ammonia-lyase
BF35_2068	COG1253	flavin adenine dinucleotide binding
BF35_2069	COG0346	lactoylglutathione lyase activity
BF35_207	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BF35_2070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BF35_2071	COG1316	TRANSCRIPTIONal
BF35_2072	COG2720	vancomycin resistance protein
BF35_2076	COG3227	Zinc metalloprotease (Elastase)
BF35_2079	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BF35_2080	COG2217	Heavy metal translocating P-type atpase
BF35_2081	COG0640	Transcriptional regulator
BF35_2082	COG0531	amino acid
BF35_2085	COG2427	Protein of unknown function (DUF1641)
BF35_2086	COG3383	formate dehydrogenase (NAD+) activity
BF35_2087	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BF35_2088	COG0454	-acetyltransferase
BF35_2088	COG0456	acetyltransferase
BF35_2090	COG0745	RESPONSE REGULATOR receiver
BF35_2091	COG5002	protein histidine kinase activity
BF35_2093	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF35_2094	COG0697	spore germination
BF35_2096	COG0281	malic enzyme
BF35_2097	COG3493	citrate carrier protein
BF35_2098	COG4565	transcriptional regulatory protein
BF35_2099	COG3290	protein histidine kinase activity
BF35_210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BF35_2101	COG4990	cell redox homeostasis
BF35_2103	COG5002	protein histidine kinase activity
BF35_2104	COG0745	RESPONSE REGULATOR receiver
BF35_2109	COG2851	Citrate transporter
BF35_2110	COG4565	transcriptional regulatory protein
BF35_2111	COG3290	protein histidine kinase activity
BF35_2114	COG2268	Band 7 protein
BF35_2115	COG1585	Membrane protein implicated in regulation of membrane protease activity
BF35_2117	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BF35_2121	COG2766	serine protein kinase
BF35_2124	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BF35_2126	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BF35_213	COG3227	Zinc metalloprotease (Elastase)
BF35_2130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BF35_2131	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BF35_2155	COG0735	belongs to the Fur family
BF35_2156	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BF35_2160	COG4555	ABC transporter
BF35_2162	COG0067	glutamate synthase
BF35_2162	COG0069	glutamate synthase activity
BF35_2162	COG0070	glutamate synthase
BF35_2163	COG4129	membrane
BF35_2164	COG1132	(ABC) transporter
BF35_2169	COG1194	a g-specific adenine glycosylase
BF35_217	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BF35_2170	COG1988	membrane-bound metal-dependent
BF35_2176	COG1090	epimerase
BF35_2177	COG0402	S-adenosylhomocysteine deaminase activity
BF35_2181	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BF35_2184	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BF35_2184	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF35_2186	COG0463	Glycosyl transferase, family 2
BF35_2190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BF35_2191	COG1263	PTS System
BF35_2191	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BF35_2192	COG2066	Belongs to the glutaminase family
BF35_2197	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BF35_2198	COG0833	amino acid
BF35_2200	COG3829	transcription factor binding
BF35_2204	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BF35_2211	COG0387	Pfam Sodium calcium exchanger
BF35_2212	COG3871	stress protein (general stress protein 26)
BF35_2215	COG0586	Pfam SNARE associated Golgi protein
BF35_2219	COG0697	spore germination
BF35_222	COG1686	Belongs to the peptidase S11 family
BF35_2220	COG2217	Heavy metal translocating P-type atpase
BF35_2221	COG1295	ribonuclease BN
BF35_2223	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BF35_2226	COG3853	Toxic anion resistance protein (TelA)
BF35_2228	COG0861	Integral membrane protein TerC family
BF35_2229	COG2310	stress, protein
BF35_223	COG2318	DinB family
BF35_2230	COG2310	stress, protein
BF35_2231	COG2310	stress, protein
BF35_2237	COG2270	Major facilitator Superfamily
BF35_2246	COG0488	(ABC) transporter
BF35_2248	COG1116	anion transmembrane transporter activity
BF35_225	COG0572	uridine kinase
BF35_2250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BF35_2253	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BF35_2259	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BF35_2259	COG2190	(PTS) system
BF35_2259	COG1263	PTS System
BF35_2260	COG0366	Alpha amylase catalytic
BF35_2261	COG0277	FAD linked oxidase domain protein
BF35_2263	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BF35_2264	COG0549	Belongs to the carbamate kinase family
BF35_2269	COG0840	transmembrane signaling receptor activity
BF35_2271	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF35_2272	COG0765	amino acid transport
BF35_2274	COG0723	plastoquinol--plastocyanin reductase activity
BF35_2274	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BF35_2275	COG2814	Major facilitator Superfamily
BF35_2276	COG3541	Predicted nucleotidyltransferase
BF35_228	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BF35_2285	COG0166	Belongs to the GPI family
BF35_2288	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF35_2289	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF35_229	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BF35_2290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF35_2291	COG0235	Class ii aldolase
BF35_2293	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BF35_2294	COG0450	alkyl hydroperoxide reductase
BF35_2297	COG1473	amidohydrolase
BF35_230	COG1024	Enoyl-CoA hydratase
BF35_2303	COG4807	Protein conserved in bacteria
BF35_2304	COG5002	protein histidine kinase activity
BF35_2305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BF35_2306	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BF35_2307	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BF35_231	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BF35_2310	COG2309	aminopeptidase activity
BF35_2311	COG2076	Multidrug Resistance protein
BF35_2312	COG1012	belongs to the aldehyde dehydrogenase family
BF35_2314	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BF35_2315	COG0546	phosphoglycolate phosphatase activity
BF35_2316	COG1597	lipid kinase activity
BF35_232	COG0511	ligase activity, forming carbon-carbon bonds
BF35_2320	COG4682	membrane
BF35_2321	COG1846	Transcriptional regulator
BF35_2322	COG0003	Pfam Anion-transporting ATPase
BF35_2325	COG1464	Belongs to the NlpA lipoprotein family
BF35_2326	COG2011	ABC-type metal ion transport system permease component
BF35_2328	COG1335	isochorismatase
BF35_233	COG0439	Biotin carboxylase
BF35_2332	COG4851	CamS sex pheromone cAM373 precursor
BF35_2334	COG0210	DNA helicase
BF35_2339	COG0151	Belongs to the GarS family
BF35_234	COG1960	acyl-CoA dehydrogenase activity
BF35_2341	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BF35_2343	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BF35_2346	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BF35_2348	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BF35_2349	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BF35_2350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BF35_2356	COG0697	spore germination
BF35_2361	COG0506	proline dehydrogenase activity
BF35_2362	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF35_2367	COG1215	transferase activity, transferring glycosyl groups
BF35_237	COG1309	transcriptional regulator
BF35_2371	COG2226	methyltransferase
BF35_2378	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BF35_2384	COG5002	protein histidine kinase activity
BF35_2386	COG2252	PERMEase
BF35_239	COG1131	(ABC) transporter
BF35_2390	COG1266	CAAX protease self-immunity
BF35_2393	COG0488	(ABC) transporter
BF35_2395	COG0456	acetyltransferase
BF35_2396	COG1214	PFAM Peptidase M22, glycoprotease
BF35_2397	COG0802	atpase or kinase
BF35_241	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BF35_2416	COG2183	response to ionizing radiation
BF35_2417	COG2337	Toxic component of a toxin-antitoxin (TA) module
BF35_2418	COG0864	Transcriptional regulator
BF35_2419	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BF35_2420	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BF35_2422	COG4294	response to UV
BF35_2423	COG0705	Rhomboid family
BF35_2425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BF35_2427	COG2814	Major facilitator Superfamily
BF35_2428	COG0531	amino acid
BF35_243	COG0584	glycerophosphoryl diester phosphodiesterase
BF35_2430	COG0179	Fumarylacetoacetate (FAA) hydrolase
BF35_2431	COG3185	4-Hydroxyphenylpyruvate dioxygenase
BF35_2437	COG0561	phosphatase activity
BF35_2438	COG4608	Belongs to the ABC transporter superfamily
BF35_2439	COG0444	Belongs to the ABC transporter superfamily
BF35_2441	COG0601	transmembrane transport
BF35_2442	COG0747	negative chemotaxis
BF35_2444	COG0488	(ABC) transporter
BF35_2448	COG5298	Protein conserved in bacteria
BF35_2450	COG0084	hydrolase, TatD family'
BF35_2453	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF35_2455	COG1609	Transcriptional regulator
BF35_2457	COG0204	Acyl-transferase
BF35_2461	COG0697	spore germination
BF35_2465	COG1910	domain protein
BF35_2466	COG0725	ABC transporter, periplasmic molybdate-binding protein
BF35_2467	COG4149	molybdate abc transporter
BF35_2470	COG0656	L-ascorbic acid biosynthetic process
BF35_2471	COG4166	transmembrane transport
BF35_2472	COG4166	transmembrane transport
BF35_2474	COG4166	transmembrane transport
BF35_2475	COG4608	Belongs to the ABC transporter superfamily
BF35_2476	COG0444	Belongs to the ABC transporter superfamily
BF35_2477	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BF35_2478	COG0601	transmembrane transport
BF35_2481	COG2814	Major facilitator Superfamily
BF35_2483	COG2271	Major facilitator Superfamily
BF35_2484	COG0277	FAD linked oxidase domain protein
BF35_2487	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_2492	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BF35_2496	COG0596	Alpha beta hydrolase
BF35_2498	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BF35_25	COG0322	excinuclease ABC activity
BF35_2500	COG4856	YbbR-like protein
BF35_2501	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BF35_2520	COG2194	sulfuric ester hydrolase activity
BF35_2522	COG0489	protein tyrosine kinase activity
BF35_2523	COG0860	N-Acetylmuramoyl-L-alanine amidase
BF35_2528	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BF35_253	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BF35_2535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BF35_2537	COG0024	Methionine aminopeptidase
BF35_2539	COG0201	protein transport
BF35_2544	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BF35_2565	COG1358	cellular component organization or biogenesis
BF35_2568	COG2813	Specifically methylates the guanine in position
BF35_257	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF35_2573	COG0250	Participates in transcription elongation, termination and antitermination
BF35_2574	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BF35_2576	COG3688	RNA-binding protein containing a PIN domain
BF35_2577	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BF35_2580	COG1045	serine acetyltransferase
BF35_2585	COG4956	integral membrane protein (PIN domain superfamily)
BF35_2587	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BF35_2588	COG0542	response to heat
BF35_2590	COG3880	PFAM UvrB UvrC protein
BF35_2610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BF35_2611	COG1396	sequence-specific DNA binding
BF35_2612	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BF35_2613	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BF35_2614	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BF35_2615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BF35_2616	COG0512	Glutamine amidotransferase of anthranilate synthase
BF35_2617	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BF35_2618	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BF35_2621	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BF35_2624	COG2208	phosphoserine phosphatase activity
BF35_2627	COG1098	S1 RNA binding domain
BF35_2631	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BF35_2632	COG3956	TIGRFAM MazG family protein
BF35_2633	COG2244	polysaccharide biosynthetic process
BF35_2634	COG2002	toxin-antitoxin pair type II binding
BF35_2635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BF35_2638	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BF35_264	COG1404	Belongs to the peptidase S8 family
BF35_2641	COG0251	oxidation-reduction process
BF35_2642	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BF35_2645	COG4466	Protein conserved in bacteria
BF35_2648	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BF35_2649	COG0084	hydrolase, TatD family'
BF35_265	COG2197	response regulator
BF35_2651	COG2002	toxin-antitoxin pair type II binding
BF35_2652	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BF35_2654	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BF35_2656	COG1774	PSP1 C-terminal conserved region
BF35_2657	COG0470	DNA polymerase III
BF35_2659	COG1982	Orn Lys Arg decarboxylase major
BF35_266	COG4585	Histidine kinase
BF35_267	COG2226	methyltransferase
BF35_2671	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BF35_2672	COG0590	tRNA wobble adenosine to inosine editing
BF35_2673	COG1335	isochorismatase
BF35_2674	COG1428	Deoxynucleoside kinase
BF35_2675	COG1428	Deoxynucleoside kinase
BF35_2681	COG1686	Belongs to the peptidase S11 family
BF35_2682	COG0516	GMP reductase activity
BF35_2682	COG0517	IMP dehydrogenase activity
BF35_2689	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BF35_2690	COG0187	DNA topoisomerase II activity
BF35_2692	COG2501	S4 domain
BF35_2693	COG0592	DNA-directed DNA polymerase activity
BF35_2697	COG0706	membrane insertase activity
BF35_2698	COG1847	R3H domain protein
BF35_2703	COG1192	Involved in chromosome partitioning
BF35_2704	COG1475	DNA binding
BF35_2706	COG0668	transmembrane transport
BF35_2707	COG4481	Protein conserved in bacteria
BF35_2708	COG0012	GTP binding
BF35_2710	COG0629	single-stranded DNA binding
BF35_2712	COG4241	membrane
BF35_2713	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BF35_2715	COG0305	Participates in initiation and elongation during chromosome replication
BF35_2721	COG0745	RESPONSE REGULATOR receiver
BF35_2722	COG5002	protein histidine kinase activity
BF35_2723	COG4863	YycH protein
BF35_2724	COG4853	Protein conserved in bacteria
BF35_2725	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BF35_2726	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BF35_273	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF35_2730	COG1164	Oligoendopeptidase f
BF35_2735	COG1272	protein, Hemolysin III
BF35_2736	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BF35_2740	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BF35_2741	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BF35_2742	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BF35_2743	COG2814	Major facilitator Superfamily
BF35_2744	COG3275	phosphorelay sensor kinase activity
BF35_2745	COG3279	Response regulator of the LytR AlgR family
BF35_2748	COG0628	permease
BF35_2749	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BF35_2749	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BF35_275	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BF35_275	COG2755	lipolytic protein G-D-S-L family
BF35_2750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BF35_2751	COG1309	transcriptional regulator
BF35_2752	COG0463	Glycosyl transferase, family 2
BF35_2756	COG0488	(ABC) transporter
BF35_2759	COG1607	acyl-coa hydrolase
BF35_2761	COG0840	transmembrane signaling receptor activity
BF35_2766	COG0477	Major facilitator Superfamily
BF35_2767	COG3279	Response regulator of the LytR AlgR family
BF35_2768	COG1966	Carbon starvation protein
BF35_2769	COG2879	small protein
BF35_277	COG3773	Cell wall hydrolase
BF35_2770	COG3706	GGDEF domain
BF35_2771	COG0351	phosphomethylpyrimidine kinase
BF35_2772	COG4585	Histidine kinase
BF35_2772	COG2203	Gaf domain
BF35_2773	COG2197	response regulator
BF35_2775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BF35_2776	COG1011	Hydrolase
BF35_2780	COG0460	homoserine dehydrogenase
BF35_2782	COG1609	Transcriptional regulator
BF35_2783	COG2755	lipolytic protein G-D-S-L family
BF35_2784	COG1131	(ABC) transporter
BF35_2785	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BF35_2787	COG2814	Major facilitator Superfamily
BF35_2788	COG0561	phosphatase activity
BF35_2789	COG2233	PERMEase
BF35_2790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BF35_2792	COG2363	Small membrane protein
BF35_2794	COG3773	Cell wall hydrolase
BF35_2797	COG0280	phosphate acetyltransferase
BF35_2798	COG0095	Lipoate-protein ligase
BF35_280	COG3718	enzyme involved in inositol metabolism
BF35_2802	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF35_2803	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF35_2804	COG1120	ATPase activity
BF35_2805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF35_2806	COG1078	dGTPase activity
BF35_2808	COG1994	Peptidase M50
BF35_2810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BF35_2811	COG0584	glycerophosphoryl diester phosphodiesterase
BF35_2812	COG0789	Transcriptional regulator
BF35_2813	COG2814	Major facilitator Superfamily
BF35_2814	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BF35_2818	COG1619	proteins homologs of microcin C7 resistance protein MccF
BF35_2819	COG4506	Protein conserved in bacteria
BF35_2821	COG1595	DNA-templated transcription, initiation
BF35_2826	COG2234	aminopeptidase activity
BF35_2827	COG0024	Methionine aminopeptidase
BF35_2828	COG1131	(ABC) transporter
BF35_2829	COG0842	Transport permease protein
BF35_2830	COG4585	Histidine kinase
BF35_2831	COG2197	response regulator
BF35_2835	COG3300	MHYT domain
BF35_2835	COG5001	Diguanylate cyclase
BF35_2837	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BF35_2838	COG0247	lactate metabolic process
BF35_2838	COG2181	nitrate reductase activity
BF35_2839	COG0183	Belongs to the thiolase family
BF35_2842	COG1960	acyl-CoA dehydrogenase activity
BF35_2843	COG1960	acyl-CoA dehydrogenase activity
BF35_2847	COG4821	SIS domain
BF35_2850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BF35_2851	COG1494	fructose-1,6-bisphosphatase
BF35_2852	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BF35_2855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BF35_2856	COG2890	protein-(glutamine-N5) methyltransferase activity
BF35_2859	COG0009	L-threonylcarbamoyladenylate synthase
BF35_286	COG0673	inositol 2-dehydrogenase activity
BF35_2862	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BF35_2863	COG2259	Doxx family
BF35_2864	COG2190	(PTS) system
BF35_2866	COG0698	ribose 5-phosphate isomerase
BF35_2872	COG0356	it plays a direct role in the translocation of protons across the membrane
BF35_288	COG2814	Major facilitator Superfamily
BF35_2882	COG3300	MHYT domain
BF35_2882	COG5001	Diguanylate cyclase
BF35_2885	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BF35_2889	COG0839	Belongs to the complex I subunit 6 family
BF35_289	COG1609	Transcriptional regulator
BF35_2891	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BF35_2892	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BF35_2893	COG1007	ATP synthesis coupled electron transport
BF35_2894	COG4836	Membrane
BF35_2896	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BF35_2897	COG2385	sporulation resulting in formation of a cellular spore
BF35_2898	COG3279	Response regulator of the LytR AlgR family
BF35_290	COG0671	phosphoesterase, PA-phosphatase related
BF35_2901	COG0739	heme binding
BF35_2902	COG1609	Transcriptional regulator
BF35_2904	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BF35_2905	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BF35_2906	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BF35_2909	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BF35_291	COG2367	Beta-lactamase
BF35_2910	COG1682	transport, permease protein
BF35_2911	COG1134	teichoic acid transport
BF35_2912	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BF35_2916	COG4464	protein tyrosine phosphatase activity
BF35_2917	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BF35_2918	COG0745	RESPONSE REGULATOR receiver
BF35_2919	COG5002	protein histidine kinase activity
BF35_2924	COG1136	(ABC) transporter
BF35_2925	COG0577	efflux transmembrane transporter activity
BF35_2933	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BF35_2934	COG4715	Zinc finger, swim domain protein
BF35_2939	COG3584	3D domain protein
BF35_2939	COG1388	LysM domain
BF35_2940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BF35_2942	COG1215	transferase activity, transferring glycosyl groups
BF35_2944	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BF35_2945	COG1388	LysM domain
BF35_2945	COG0791	NLP P60 protein
BF35_2947	COG1368	sulfuric ester hydrolase activity
BF35_295	COG1595	DNA-templated transcription, initiation
BF35_2950	COG2389	metal-binding protein
BF35_2952	COG1620	l-lactate permease
BF35_2954	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BF35_2955	COG1294	oxidase, subunit
BF35_2956	COG1271	oxidase subunit
BF35_2958	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BF35_2959	COG0583	DNA-binding transcription factor activity
BF35_296	COG0768	penicillin binding
BF35_2960	COG1511	domain protein
BF35_2961	COG0346	lactoylglutathione lyase activity
BF35_2963	COG1301	dicarboxylic acid transport
BF35_2964	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BF35_2966	COG1447	Phosphotransferase system cellobiose-specific component IIA
BF35_2970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BF35_2971	COG1447	Phosphotransferase system cellobiose-specific component IIA
BF35_2972	COG1486	melibiose metabolic process
BF35_2976	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BF35_2976	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BF35_2978	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BF35_2979	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BF35_2980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BF35_2981	COG1316	TRANSCRIPTIONal
BF35_2982	COG1739	Uncharacterized protein family UPF0029
BF35_2983	COG1307	EDD domain protein, DegV family
BF35_2984	COG1733	regulation of RNA biosynthetic process
BF35_2985	COG0791	NLP P60 protein
BF35_2985	COG1388	LysM domain
BF35_2986	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BF35_2987	COG1040	competence protein
BF35_2988	COG1278	Cold shock
BF35_2989	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BF35_2991	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BF35_2993	COG2884	Cell division ATP-binding protein ftsE
BF35_2994	COG2177	Part of the ABC transporter FtsEX involved in
BF35_2995	COG0793	Belongs to the peptidase S41A family
BF35_2995	COG3409	Peptidoglycan-binding domain 1 protein
BF35_2996	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BF35_2997	COG1132	(ABC) transporter
BF35_300	COG0110	maltose O-acetyltransferase activity
BF35_3000	COG0655	NAD(P)H dehydrogenase (quinone) activity
BF35_3002	COG0583	DNA-binding transcription factor activity
BF35_3008	COG0789	Transcriptional regulator
BF35_3011	COG0556	nucleotide-excision repair
BF35_3012	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BF35_3014	COG1950	PFAM Membrane protein of
BF35_3018	COG0110	maltose O-acetyltransferase activity
BF35_3019	COG0457	Tetratricopeptide repeat
BF35_302	COG2195	Cleaves the N-terminal amino acid of tripeptides
BF35_3020	COG0492	ferredoxin-NADP+ reductase activity
BF35_3022	COG1051	belongs to the nudix hydrolase family
BF35_3024	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BF35_3026	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BF35_3028	COG2323	membrane
BF35_3031	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF35_3036	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BF35_3039	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BF35_3046	COG1346	cytolysis
BF35_3047	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BF35_3048	COG1647	Serine aminopeptidase, S33
BF35_3049	COG0557	exoribonuclease II activity
BF35_3058	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF35_3059	COG0488	(ABC) transporter
BF35_306	COG1846	Transcriptional regulator
BF35_3064	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BF35_3066	COG0840	transmembrane signaling receptor activity
BF35_3066	COG3290	protein histidine kinase activity
BF35_3068	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BF35_3069	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BF35_307	COG3961	Belongs to the TPP enzyme family
BF35_3070	COG1252	NADH dehydrogenase
BF35_3073	COG1733	regulation of RNA biosynthetic process
BF35_3074	COG2814	Major facilitator Superfamily
BF35_3075	COG0656	L-ascorbic acid biosynthetic process
BF35_3078	COG2910	NAD(P)H-binding
BF35_3079	COG1115	amino acid carrier protein
BF35_308	COG2226	methyltransferase
BF35_3080	COG1115	amino acid carrier protein
BF35_3081	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BF35_3082	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BF35_3086	COG1611	Belongs to the LOG family
BF35_3090	COG0783	Belongs to the Dps family
BF35_3091	COG1115	amino acid carrier protein
BF35_3092	COG0490	domain, Protein
BF35_3093	COG0475	glutathione-regulated potassium exporter activity
BF35_3094	COG0586	Pfam SNARE associated Golgi protein
BF35_3097	COG1741	Belongs to the pirin family
BF35_3098	COG3227	Zinc metalloprotease (Elastase)
BF35_3099	COG2151	metal-sulfur cluster biosynthetic enzyme
BF35_310	COG0500	methyltransferase
BF35_310	COG3615	Tellurite resistance protein tehB
BF35_3100	COG0840	transmembrane signaling receptor activity
BF35_3105	COG5002	protein histidine kinase activity
BF35_3106	COG0745	RESPONSE REGULATOR receiver
BF35_3107	COG1376	ErfK ybiS ycfS ynhG family protein
BF35_3109	COG0586	Pfam SNARE associated Golgi protein
BF35_311	COG0577	efflux transmembrane transporter activity
BF35_311	COG1136	(ABC) transporter
BF35_3116	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF35_3121	COG0531	amino acid
BF35_3122	COG2814	Major facilitator Superfamily
BF35_3126	COG0840	transmembrane signaling receptor activity
BF35_3127	COG0011	TIGRFAM Protein of
BF35_3130	COG1686	Belongs to the peptidase S11 family
BF35_3132	COG1024	Enoyl-CoA hydratase
BF35_3132	COG1250	3-hydroxyacyl-CoA dehydrogenase
BF35_3133	COG0183	Belongs to the thiolase family
BF35_3135	COG1960	acyl-CoA dehydrogenase activity
BF35_3136	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF35_3137	COG1309	transcriptional regulator
BF35_315	COG1309	transcriptional regulator
BF35_3153	COG1393	Belongs to the ArsC family
BF35_3155	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BF35_3156	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF35_3158	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BF35_3159	COG2011	ABC-type metal ion transport system permease component
BF35_3160	COG1464	Belongs to the NlpA lipoprotein family
BF35_3161	COG1464	Belongs to the NlpA lipoprotein family
BF35_3162	COG0396	ATPase activity
BF35_3163	COG0719	Fe-S assembly protein
BF35_3164	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BF35_3165	COG0822	iron-sulfur transferase activity
BF35_3166	COG0719	Fe-S assembly protein
BF35_3168	COG1695	Transcriptional regulator
BF35_3169	COG0737	Belongs to the 5'-nucleotidase family
BF35_3170	COG3377	Domain of unknown function (DUF1805)
BF35_3172	COG0739	heme binding
BF35_3177	COG4377	Putative membrane peptidase family (DUF2324)
BF35_3178	COG0789	Transcriptional regulator
BF35_3180	COG4470	Protein conserved in bacteria
BF35_3183	COG1494	fructose-1,6-bisphosphatase
BF35_3184	COG2445	Protein of unknown function DUF86
BF35_3186	COG0647	UMP catabolic process
BF35_3188	COG2249	NAD(P)H dehydrogenase (quinone) activity
BF35_3190	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BF35_3191	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BF35_3193	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BF35_3194	COG4837	Protein of unknown function (DUF1462)
BF35_3197	COG2824	Alkylphosphonate utilization operon protein PhnA
BF35_3198	COG0390	transport system, permease component
BF35_3200	COG1252	NADH dehydrogenase
BF35_3203	COG0316	Belongs to the HesB IscA family
BF35_3207	COG1683	Conserved Protein
BF35_3210	COG3708	Transcriptional regulator
BF35_3212	COG1252	NADH dehydrogenase
BF35_3215	COG3584	3D domain protein
BF35_3218	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BF35_3219	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BF35_322	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF35_3220	COG1268	BioY protein
BF35_3222	COG2050	protein possibly involved in aromatic compounds catabolism
BF35_3223	COG0423	glycine-tRNA ligase activity
BF35_3226	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BF35_3227	COG5018	Exonuclease
BF35_3231	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BF35_3233	COG2267	carboxylic ester hydrolase activity
BF35_3234	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BF35_3235	COG1522	sequence-specific DNA binding
BF35_3236	COG0436	Aminotransferase
BF35_3237	COG1098	S1 RNA binding domain
BF35_3238	COG2155	Conserved Protein
BF35_3240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BF35_3242	COG1285	pathogenesis
BF35_3250	COG0544	peptidyl-prolyl cis-trans isomerase activity
BF35_326	COG1846	Transcriptional regulator
BF35_3269	COG1595	DNA-templated transcription, initiation
BF35_3271	COG0039	L-malate dehydrogenase activity
BF35_3272	COG1404	Belongs to the peptidase S8 family
BF35_3276	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BF35_3278	COG0058	SHG alpha-glucan phosphorylase activity
BF35_3283	COG1278	Cold shock
BF35_3284	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BF35_3285	COG1575	Belongs to the MenA family. Type 1 subfamily
BF35_3286	COG1169	isochorismate synthase
BF35_3288	COG0596	Alpha beta hydrolase
BF35_3289	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BF35_3291	COG4948	Mandelate Racemase Muconate Lactonizing
BF35_3295	COG3964	amidohydrolase
BF35_33	COG4667	esterase of the alpha-beta hydrolase superfamily
BF35_330	COG2971	BadF BadG BcrA BcrD
BF35_3302	COG0577	efflux transmembrane transporter activity
BF35_3303	COG1136	(ABC) transporter
BF35_3304	COG0577	efflux transmembrane transporter activity
BF35_3305	COG0577	efflux transmembrane transporter activity
BF35_3306	COG2205	protein histidine kinase activity
BF35_3307	COG0745	RESPONSE REGULATOR receiver
BF35_3308	COG0640	Transcriptional regulator
BF35_3309	COG5658	integral membrane protein
BF35_3310	COG3708	Transcriptional regulator
BF35_3310	COG2207	Transcriptional regulator
BF35_3311	COG1136	(ABC) transporter
BF35_3312	COG0577	efflux transmembrane transporter activity
BF35_3315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BF35_3316	COG0586	Pfam SNARE associated Golgi protein
BF35_3321	COG0577	efflux transmembrane transporter activity
BF35_3325	COG1597	lipid kinase activity
BF35_3331	COG0745	RESPONSE REGULATOR receiver
BF35_3332	COG5002	protein histidine kinase activity
BF35_3333	COG3859	Proton-coupled thiamine transporter YuaJ
BF35_3341	COG1842	Phage shock protein A
BF35_3346	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF35_335	COG1649	PFAM Uncharacterised BCR, COG1649
BF35_3351	COG1294	oxidase, subunit
BF35_3352	COG1271	oxidase subunit
BF35_3354	COG0288	reversible hydration of carbon dioxide
BF35_3359	COG0494	nUDIX hydrolase
BF35_3364	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BF35_3365	COG1116	anion transmembrane transporter activity
BF35_3366	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BF35_3369	COG1368	sulfuric ester hydrolase activity
BF35_3370	COG2267	carboxylic ester hydrolase activity
BF35_3371	COG4191	Histidine kinase
BF35_3372	COG5002	protein histidine kinase activity
BF35_3386	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF35_3389	COG0521	Mo-molybdopterin cofactor biosynthetic process
BF35_3391	COG0438	transferase activity, transferring glycosyl groups
BF35_3392	COG0671	phosphoesterase, PA-phosphatase related
BF35_3393	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BF35_3394	COG2267	carboxylic ester hydrolase activity
BF35_3399	COG1794	racemase activity, acting on amino acids and derivatives
BF35_340	COG1595	DNA-templated transcription, initiation
BF35_3402	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BF35_3403	COG1242	4 iron, 4 sulfur cluster binding
BF35_3407	COG1136	(ABC) transporter
BF35_3409	COG0582	viral genome integration into host DNA
BF35_3410	COG0490	domain, Protein
BF35_3411	COG0475	glutathione-regulated potassium exporter activity
BF35_3412	COG2814	Major facilitator Superfamily
BF35_3420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BF35_3422	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BF35_3426	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BF35_3427	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BF35_3429	COG0303	'Molybdopterin
BF35_343	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BF35_3430	COG1763	Mo-molybdopterin cofactor biosynthetic process
BF35_3431	COG0314	molybdopterin synthase activity
BF35_3436	COG1329	Transcriptional regulator
BF35_3440	COG3832	glyoxalase III activity
BF35_3442	COG2814	Major facilitator Superfamily
BF35_3443	COG2081	HI0933 family
BF35_3444	COG2244	polysaccharide biosynthetic process
BF35_3445	COG1187	pseudouridine synthase activity
BF35_3446	COG1349	DNA-binding transcription factor activity
BF35_3447	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BF35_3449	COG1523	belongs to the glycosyl hydrolase 13 family
BF35_3450	COG0510	thiamine kinase activity
BF35_3453	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF35_3455	COG1363	Peptidase, m42
BF35_3456	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BF35_3457	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF35_3459	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BF35_3462	COG1674	ftsk spoiiie
BF35_3466	COG1695	Transcriptional regulator
BF35_3467	COG0789	Transcriptional regulator
BF35_3468	COG0697	spore germination
BF35_3469	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF35_3473	COG2309	aminopeptidase activity
BF35_3475	COG3118	belongs to the thioredoxin family
BF35_3476	COG4851	CamS sex pheromone cAM373 precursor
BF35_3477	COG1609	Transcriptional regulator
BF35_3484	COG0666	response to abiotic stimulus
BF35_3486	COG0745	RESPONSE REGULATOR receiver
BF35_3489	COG0123	including yeast histone deacetylase and acetoin utilization protein
BF35_3490	COG0517	IMP dehydrogenase activity
BF35_3491	COG0454	-acetyltransferase
BF35_3492	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BF35_3494	COG1595	DNA-templated transcription, initiation
BF35_350	COG1396	sequence-specific DNA binding
BF35_3500	COG0626	cystathionine gamma-synthase activity
BF35_3501	COG1956	GAF domain-containing protein
BF35_3502	COG1309	transcriptional regulator
BF35_3503	COG0697	spore germination
BF35_3504	COG0583	DNA-binding transcription factor activity
BF35_3506	COG1104	cysteine desulfurase activity
BF35_3509	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BF35_3511	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BF35_3512	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BF35_3514	COG3874	Sporulation protein YtfJ
BF35_3515	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BF35_3516	COG0827	DNA restriction-modification system
BF35_3521	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF35_3529	COG0589	response to stress
BF35_3530	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_3534	COG1476	TRANSCRIPTIONal
BF35_3536	COG0662	Cupin 2, conserved barrel domain protein
BF35_3537	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF35_354	COG1132	(ABC) transporter
BF35_3545	COG0006	proline dipeptidase activity
BF35_3548	COG4109	DRTGG domain
BF35_355	COG1132	(ABC) transporter
BF35_3551	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BF35_3554	COG0587	DNA-directed DNA polymerase activity
BF35_3555	COG0281	malic enzyme
BF35_3556	COG1725	Transcriptional regulator
BF35_3561	COG3030	protein affecting phage T7 exclusion by the F plasmid
BF35_3562	COG0628	permease
BF35_3564	COG0372	Belongs to the citrate synthase family
BF35_3565	COG0538	isocitrate dehydrogenase activity
BF35_3570	COG0745	RESPONSE REGULATOR receiver
BF35_3571	COG5002	protein histidine kinase activity
BF35_3572	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BF35_3572	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BF35_3574	COG1971	Probably functions as a manganese efflux pump
BF35_3575	COG0237	dephospho-CoA kinase activity
BF35_3576	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BF35_3577	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BF35_3579	COG3611	Membrane attachment protein
BF35_358	COG2258	MOSC domain
BF35_3580	COG1484	DNA-dependent DNA replication
BF35_3582	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BF35_3583	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BF35_3587	COG1363	Peptidase, m42
BF35_3588	COG1309	transcriptional regulator
BF35_3589	COG1566	PFAM secretion protein HlyD family protein
BF35_359	COG0583	DNA-binding transcription factor activity
BF35_3590	COG2814	Major facilitator Superfamily
BF35_3592	COG1418	mRNA catabolic process
BF35_3594	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BF35_3597	COG0017	Asparaginyl-tRNA synthetase
BF35_3603	COG1286	toxin biosynthetic process
BF35_3604	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BF35_3604	COG1796	DNA polymerase
BF35_3607	COG1187	pseudouridine synthase activity
BF35_3608	COG1114	Component of the transport system for branched-chain amino acids
BF35_3609	COG5386	Cell surface protein
BF35_3611	COG5386	Cell surface protein
BF35_3614	COG1120	ATPase activity
BF35_3615	COG4509	Sortase family
BF35_3617	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BF35_3618	COG4895	conserved protein (DUF2196)
BF35_362	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BF35_3620	COG0745	RESPONSE REGULATOR receiver
BF35_3621	COG2205	protein histidine kinase activity
BF35_3622	COG1131	(ABC) transporter
BF35_3628	COG2318	DinB family
BF35_363	COG0583	DNA-binding transcription factor activity
BF35_3630	COG0318	PFAM AMP-dependent synthetase and ligase
BF35_3631	COG1309	transcriptional regulator
BF35_3632	COG1024	Enoyl-CoA hydratase
BF35_3633	COG2086	electron transfer activity
BF35_3634	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BF35_3635	COG3118	belongs to the thioredoxin family
BF35_3637	COG1719	4-vinyl reductase, 4VR
BF35_3638	COG2009	succinate dehydrogenase
BF35_3639	COG1053	succinate dehydrogenase
BF35_3640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BF35_3641	COG0824	Thioesterase
BF35_3642	COG1876	peptidase activity
BF35_3643	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BF35_3644	COG1360	Flagellar Motor Protein
BF35_3645	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BF35_3646	COG4152	abc transporter atp-binding protein
BF35_3647	COG1668	transmembrane transport
BF35_3648	COG1959	2 iron, 2 sulfur cluster binding
BF35_365	COG0561	phosphatase activity
BF35_3650	COG0697	spore germination
BF35_3651	COG1396	sequence-specific DNA binding
BF35_3652	COG1983	PspC domain protein
BF35_3653	COG0402	S-adenosylhomocysteine deaminase activity
BF35_3654	COG2233	PERMEase
BF35_3655	COG2197	response regulator
BF35_3658	COG1309	transcriptional regulator
BF35_366	COG0010	Belongs to the arginase family
BF35_3662	COG5401	PFAM Sporulation and spore germination
BF35_3665	COG0622	Phosphoesterase
BF35_3677	COG1067	ATP-dependent peptidase activity
BF35_3677	COG0470	DNA polymerase III
BF35_3680	COG1764	response to oxidative stress
BF35_3681	COG1846	Transcriptional regulator
BF35_3683	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BF35_3685	COG1587	Uroporphyrinogen-III synthase
BF35_3686	COG0113	porphobilinogen synthase activity
BF35_3688	COG1388	LysM domain
BF35_369	COG1278	Cold shock
BF35_3691	COG0285	dihydrofolate synthase activity
BF35_3696	COG3344	reverse transcriptase
BF35_3698	COG1077	Cell shape determining protein MreB Mrl
BF35_3699	COG1792	Involved in formation and maintenance of cell shape
BF35_370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF35_3702	COG2894	cell division
BF35_3703	COG0739	heme binding
BF35_3704	COG1994	Peptidase M50
BF35_3705	COG1530	ribonuclease E activity
BF35_3707	COG2868	ribosomal protein
BF35_3709	COG3290	protein histidine kinase activity
BF35_3711	COG0745	RESPONSE REGULATOR receiver
BF35_3712	COG5002	protein histidine kinase activity
BF35_3713	COG1136	(ABC) transporter
BF35_3714	COG0577	efflux transmembrane transporter activity
BF35_3715	COG0577	efflux transmembrane transporter activity
BF35_3716	COG0077	Prephenate dehydratase
BF35_3717	COG2258	MOSC domain
BF35_3718	COG1827	regulation of RNA biosynthetic process
BF35_3719	COG1104	cysteine desulfurase activity
BF35_3720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BF35_3721	COG0157	Belongs to the NadC ModD family
BF35_3726	COG0640	Transcriptional regulator
BF35_3727	COG0697	spore germination
BF35_3729	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BF35_373	COG0596	Alpha beta hydrolase
BF35_3735	COG1862	Preprotein translocase
BF35_3737	COG2323	membrane
BF35_3738	COG2244	polysaccharide biosynthetic process
BF35_3740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BF35_3740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BF35_3741	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BF35_3742	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BF35_3742	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BF35_3744	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BF35_3749	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BF35_3751	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BF35_3752	COG1959	2 iron, 2 sulfur cluster binding
BF35_3753	COG1104	cysteine desulfurase activity
BF35_3756	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BF35_3760	COG0628	permease
BF35_3766	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BF35_3772	COG0768	penicillin binding
BF35_3777	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BF35_3778	COG0626	cystathionine gamma-synthase activity
BF35_3779	COG1454	alcohol dehydrogenase
BF35_3779	COG1012	belongs to the aldehyde dehydrogenase family
BF35_378	COG1247	-acetyltransferase
BF35_3781	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF35_3790	COG2259	Doxx family
BF35_3791	COG2514	catechol 2,3-dioxygenase activity
BF35_3793	COG3186	Phenylalanine-4-hydroxylase
BF35_3794	COG1404	Belongs to the peptidase S8 family
BF35_38	COG3878	Protein conserved in bacteria
BF35_3801	COG2267	carboxylic ester hydrolase activity
BF35_3803	COG1785	Belongs to the alkaline phosphatase family
BF35_3805	COG2357	RelA SpoT domain protein
BF35_3806	COG0778	Nitroreductase
BF35_3808	COG1595	DNA-templated transcription, initiation
BF35_3810	COG1191	sigma factor activity
BF35_3813	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BF35_3814	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BF35_3816	COG1534	Rna-binding protein
BF35_3818	COG1713	HD superfamily hydrolase involved in NAD metabolism
BF35_3819	COG0799	negative regulation of ribosome biogenesis
BF35_3820	COG2226	methyltransferase
BF35_3821	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BF35_3822	COG1555	photosystem II stabilization
BF35_3822	COG1596	polysaccharide export
BF35_3823	COG2131	deaminase
BF35_3824	COG2333	competence protein COMEC
BF35_3824	COG0658	competence protein
BF35_3826	COG1466	dna polymerase III delta subunit
BF35_3831	COG1733	regulation of RNA biosynthetic process
BF35_3832	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BF35_3838	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BF35_3839	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BF35_3841	COG1610	YqeY-like protein
BF35_3844	COG1702	phosphate starvation-inducible protein PhoH
BF35_3845	COG1480	7TM receptor with intracellular HD hydrolase
BF35_3847	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BF35_3848	COG0295	cytidine deaminase activity
BF35_3849	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BF35_385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF35_3852	COG0517	IMP dehydrogenase activity
BF35_3854	COG0358	DNA primase activity
BF35_3855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BF35_3857	COG2384	SAM-dependent methyltransferase
BF35_3858	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BF35_3864	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF35_3865	COG1121	(ABC) transporter
BF35_3866	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BF35_3867	COG0735	belongs to the Fur family
BF35_3872	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BF35_3873	COG0477	Major facilitator Superfamily
BF35_3875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BF35_3876	COG0573	inorganic phosphate transmembrane transporter activity
BF35_3877	COG0581	inorganic phosphate transmembrane transporter activity
BF35_3878	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BF35_3879	COG0704	Plays a role in the regulation of phosphate uptake
BF35_3880	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BF35_3882	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BF35_3883	COG4483	Protein conserved in bacteria
BF35_3884	COG1940	carbohydrate kinase activity
BF35_3886	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF35_3890	COG0626	cystathionine gamma-synthase activity
BF35_3891	COG0626	cystathionine gamma-synthase activity
BF35_3892	COG0646	methionine synthase
BF35_3892	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BF35_3893	COG1410	methionine synthase
BF35_3893	COG0646	methionine synthase
BF35_3903	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BF35_3917	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BF35_3918	COG1459	type II secretion system
BF35_3920	COG4970	Tfp pilus assembly protein FimT
BF35_3931	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BF35_3937	COG1725	Transcriptional regulator
BF35_3945	COG2076	Multidrug Resistance protein
BF35_3946	COG2076	Multidrug Resistance protein
BF35_3948	COG1609	Transcriptional regulator
BF35_395	COG2226	methyltransferase
BF35_3950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BF35_3951	COG0095	Lipoate-protein ligase
BF35_3958	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BF35_3959	COG3872	metal-dependent enzyme
BF35_3962	COG0006	proline dipeptidase activity
BF35_3967	COG3854	ATPases associated with a variety of cellular activities
BF35_397	COG0028	Belongs to the TPP enzyme family
BF35_3976	COG0511	ligase activity, forming carbon-carbon bonds
BF35_3977	COG0439	Biotin carboxylase
BF35_3978	COG1302	Protein conserved in bacteria
BF35_3983	COG0142	geranyltranstransferase activity
BF35_3985	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BF35_3987	COG0497	DNA recombination
BF35_3988	COG0750	zinc metalloprotease
BF35_3989	COG0745	RESPONSE REGULATOR receiver
BF35_3991	COG0789	Transcriptional regulator
BF35_4	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF35_400	COG2814	Major facilitator Superfamily
BF35_4000	COG0582	viral genome integration into host DNA
BF35_4008	COG3093	addiction module antidote protein HigA
BF35_4009	COG0584	glycerophosphoryl diester phosphodiesterase
BF35_4011	COG3290	protein histidine kinase activity
BF35_4011	COG3829	transcription factor binding
BF35_4012	COG0280	phosphate acetyltransferase
BF35_4013	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BF35_4015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BF35_4016	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BF35_4017	COG0022	dehydrogenase e1 component
BF35_4018	COG0508	dehydrogenase complex catalyzes the overall conversion of
BF35_4019	COG0772	Belongs to the SEDS family
BF35_402	COG1136	(ABC) transporter
BF35_4020	COG2323	membrane
BF35_4024	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF35_4025	COG0765	amino acid transport
BF35_4026	COG1126	abc transporter atp-binding protein
BF35_4027	COG4129	membrane
BF35_4028	COG1376	ErfK ybiS ycfS ynhG family protein
BF35_4030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF35_4031	COG2195	Cleaves the N-terminal amino acid of tripeptides
BF35_4032	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BF35_4035	COG1760	l-serine dehydratase
BF35_4036	COG1760	l-serine dehydratase
BF35_4037	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BF35_4038	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF35_4039	COG0300	oxidoreductase activity
BF35_404	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BF35_4044	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BF35_4048	COG1522	sequence-specific DNA binding
BF35_405	COG1187	pseudouridine synthase activity
BF35_4050	COG0737	Belongs to the 5'-nucleotidase family
BF35_4053	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BF35_4056	COG1073	alpha beta
BF35_4056	COG2226	methyltransferase
BF35_4057	COG4106	trans-aconitate 2-methyltransferase activity
BF35_406	COG2329	Antibiotic biosynthesis monooxygenase
BF35_4062	COG0307	riboflavin synthase, alpha
BF35_4063	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BF35_4063	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BF35_4066	COG1073	alpha beta
BF35_4067	COG0456	acetyltransferase
BF35_4068	COG1609	Transcriptional regulator
BF35_4069	COG2056	Na+-H+ antiporter family
BF35_4070	COG0596	Alpha beta hydrolase
BF35_4072	COG0737	Belongs to the 5'-nucleotidase family
BF35_4072	COG4085	toxin activity
BF35_4072	COG1525	nuclease
BF35_4074	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BF35_4074	COG0456	acetyltransferase
BF35_4075	COG0656	L-ascorbic acid biosynthetic process
BF35_4076	COG0667	Aldo Keto reductase
BF35_4080	COG1300	Membrane
BF35_4081	COG0735	belongs to the Fur family
BF35_4083	COG4974	Belongs to the 'phage' integrase family
BF35_4088	COG0598	Magnesium transport protein CorA
BF35_409	COG1115	amino acid carrier protein
BF35_4091	COG1846	Transcriptional regulator
BF35_4095	COG1131	(ABC) transporter
BF35_4096	COG1725	Transcriptional regulator
BF35_4097	COG1686	Belongs to the peptidase S11 family
BF35_4101	COG0733	neurotransmitter:sodium symporter activity
BF35_4106	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF35_4109	COG0697	spore germination
BF35_411	COG2318	DinB family
BF35_4110	COG0561	phosphatase activity
BF35_4111	COG4086	secreted protein
BF35_4112	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BF35_4113	COG0456	acetyltransferase
BF35_4114	COG1547	Domain of unknown function (DUF309)
BF35_4119	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BF35_4123	COG3711	transcriptional antiterminator
BF35_4124	COG1263	PTS System
BF35_4124	COG2190	(PTS) system
BF35_4124	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BF35_4129	COG0778	Nitroreductase
BF35_413	COG0776	regulation of translation
BF35_4130	COG3706	GGDEF domain
BF35_4132	COG2084	Dehydrogenase
BF35_4139	COG0436	Aminotransferase
BF35_4140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BF35_4144	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_4145	COG1695	Transcriptional regulator
BF35_4152	COG0183	Belongs to the thiolase family
BF35_4153	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BF35_416	COG2814	Major facilitator Superfamily
BF35_4160	COG3842	ATPase activity
BF35_4161	COG0366	Alpha amylase catalytic
BF35_4163	COG2182	Extracellular solute-binding protein
BF35_4164	COG1175	transmembrane transport
BF35_4165	COG3833	ABC-type maltose transport systems, permease component
BF35_4166	COG1609	Transcriptional regulator
BF35_4167	COG0436	Aminotransferase
BF35_4169	COG2205	protein histidine kinase activity
BF35_4171	COG3209	COG3209 Rhs family protein
BF35_4175	COG2814	Major facilitator Superfamily
BF35_418	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BF35_4182	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BF35_4184	COG1408	metallophosphoesterase
BF35_4185	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_4186	COG2200	EAL domain
BF35_4187	COG2200	EAL domain
BF35_419	COG1535	isochorismatase
BF35_419	COG3433	isochorismatase activity
BF35_4190	COG4703	Protein of unknown function (DUF1797)
BF35_4192	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BF35_4194	COG0517	IMP dehydrogenase activity
BF35_4195	COG0583	DNA-binding transcription factor activity
BF35_4199	COG0569	domain protein
BF35_420	COG1021	2,3-dihydroxybenzoate-AMP ligase
BF35_4200	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BF35_4202	COG0561	phosphatase activity
BF35_4203	COG0242	peptide deformylase activity
BF35_4205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BF35_4206	COG0022	dehydrogenase e1 component
BF35_421	COG1169	isochorismate synthase
BF35_4216	COG1982	Orn Lys Arg decarboxylase major
BF35_422	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_4220	COG0483	inositol monophosphate 1-phosphatase activity
BF35_4225	COG4896	Protein conserved in bacteria
BF35_4227	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BF35_4228	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BF35_423	COG2223	nitrite transmembrane transporter activity
BF35_4230	COG0772	Belongs to the SEDS family
BF35_4231	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BF35_4238	COG3336	cytochrome c oxidase
BF35_4240	COG2340	Cysteine-rich secretory protein family
BF35_4243	COG0406	alpha-ribazole phosphatase activity
BF35_4244	COG3679	Belongs to the UPF0342 family
BF35_4247	COG0742	ribosomal rna small subunit methyltransferase
BF35_4248	COG3314	Sporulation integral membrane protein YlbJ
BF35_4250	COG1752	Esterase of the alpha-beta hydrolase superfamily
BF35_4251	COG3480	Lon protease (S16) C-terminal proteolytic domain
BF35_4253	COG1399	metal-binding, possibly nucleic acid-binding protein
BF35_4257	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BF35_4260	COG4839	cell division protein FtsL
BF35_4262	COG0768	penicillin binding
BF35_4263	COG0768	penicillin binding
BF35_4264	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BF35_4267	COG0772	Belongs to the SEDS family
BF35_4268	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BF35_4270	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BF35_4271	COG0849	cell division
BF35_4272	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BF35_4274	COG1191	sigma factor activity
BF35_4275	COG1191	sigma factor activity
BF35_4276	COG1873	PFAM PRC-barrel domain
BF35_4278	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BF35_428	COG0420	3'-5' exonuclease activity
BF35_4280	COG0762	integral membrane protein
BF35_4281	COG2302	S4 RNA-binding domain
BF35_4282	COG3599	regulation of cell shape
BF35_4286	COG0564	pseudouridine synthase activity
BF35_4299	COG3069	C4-dicarboxylate transmembrane transporter activity
BF35_4303	COG0006	proline dipeptidase activity
BF35_4306	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BF35_4307	COG1561	YicC-like family, N-terminal region
BF35_4309	COG0194	GDP metabolic process
BF35_431	COG1024	Enoyl-CoA hydratase
BF35_4311	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BF35_4312	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BF35_4313	COG0242	peptide deformylase activity
BF35_4315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BF35_4315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BF35_4317	COG0631	protein serine/threonine phosphatase activity
BF35_4318	COG2815	serine threonine protein kinase
BF35_4318	COG0515	serine threonine protein kinase
BF35_432	COG1280	lysine exporter protein (LysE YggA)
BF35_4320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BF35_4321	COG1564	THIamine pyrophosphokinase
BF35_4323	COG1302	Protein conserved in bacteria
BF35_4324	COG1461	Dihydroxyacetone kinase
BF35_4325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BF35_4328	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BF35_4329	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_433	COG1012	belongs to the aldehyde dehydrogenase family
BF35_4332	COG1196	nuclear chromosome segregation
BF35_4333	COG0552	protein localization to endoplasmic reticulum
BF35_4335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BF35_4337	COG1837	Belongs to the UPF0109 family
BF35_434	COG2084	Dehydrogenase
BF35_4345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BF35_4346	COG0758	DNA mediated transformation
BF35_4347	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BF35_4349	COG4974	Belongs to the 'phage' integrase family
BF35_435	COG1960	acyl-CoA dehydrogenase activity
BF35_4355	COG0528	UMP kinase activity
BF35_4358	COG4589	Belongs to the CDS family
BF35_436	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BF35_4360	COG0750	zinc metalloprotease
BF35_4364	COG0195	Participates in both transcription termination and antitermination
BF35_4365	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BF35_4366	COG1358	cellular component organization or biogenesis
BF35_4368	COG1550	Protein conserved in bacteria
BF35_437	COG2079	MmgE PrpD family protein
BF35_4371	COG0196	riboflavin kinase activity
BF35_4374	COG0726	polysaccharide deacetylase
BF35_4375	COG0612	Peptidase, M16
BF35_4376	COG1873	PFAM PRC-barrel domain
BF35_4377	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BF35_4378	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BF35_4379	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BF35_438	COG0372	Belongs to the citrate synthase family
BF35_4380	COG0527	aspartate kinase activity
BF35_4382	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BF35_4383	COG0740	serine-type endopeptidase activity
BF35_4385	COG1674	ftsk spoiiie
BF35_4387	COG2188	Transcriptional regulator
BF35_439	COG2814	Major facilitator Superfamily
BF35_4392	COG0612	Peptidase, M16
BF35_4393	COG0612	Peptidase, M16
BF35_4394	COG0300	oxidoreductase activity
BF35_4397	COG1426	Protein conserved in bacteria
BF35_4398	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BF35_4402	COG1692	metallophosphoesterase
BF35_4403	COG2359	stage V sporulation protein S
BF35_4405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BF35_4405	COG0674	pyruvate-flavodoxin oxidoreductase activity
BF35_4406	COG1013	pyruvate-flavodoxin oxidoreductase activity
BF35_4408	COG4550	Control of competence regulator ComK, YlbF/YmcA
BF35_441	COG4499	WXG100 protein secretion system (Wss), protein YukC
BF35_441	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BF35_4412	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BF35_4414	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BF35_4415	COG1368	sulfuric ester hydrolase activity
BF35_4417	COG3773	Cell wall hydrolase
BF35_4418	COG1404	Belongs to the peptidase S8 family
BF35_4421	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF35_4422	COG1380	Effector of murein hydrolase LrgA
BF35_4423	COG1346	cytolysis
BF35_4425	COG0384	phenazine biosynthesis protein PhzF
BF35_4427	COG1086	Polysaccharide biosynthesis protein
BF35_4431	COG3300	MHYT domain
BF35_4431	COG5001	Diguanylate cyclase
BF35_4435	COG2364	Membrane
BF35_4437	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BF35_4438	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BF35_4439	COG2169	Transcriptional regulator
BF35_4440	COG0708	Exodeoxyribonuclease III
BF35_4441	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF35_4442	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF35_4443	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF35_4444	COG1120	ATPase activity
BF35_4445	COG2819	hydrolase of the alpha beta superfamily
BF35_4447	COG1937	Protein conserved in bacteria
BF35_4448	COG2608	mercury ion transmembrane transporter activity
BF35_4449	COG2217	Heavy metal translocating P-type atpase
BF35_445	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_4452	COG2116	formate transmembrane transporter activity
BF35_4453	COG1408	metallophosphoesterase
BF35_4455	COG1113	amino acid transport
BF35_4458	COG2322	membrane
BF35_4459	COG1979	alcohol dehydrogenase
BF35_4460	COG1349	DNA-binding transcription factor activity
BF35_4461	COG1105	Belongs to the carbohydrate kinase PfkB family
BF35_4462	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BF35_4462	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BF35_4462	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BF35_4463	COG3584	3D domain protein
BF35_4463	COG1388	LysM domain
BF35_4469	COG0464	growth
BF35_4471	COG2860	membrane
BF35_4472	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BF35_4473	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BF35_4474	COG0789	Transcriptional regulator
BF35_4475	COG0174	glutamine synthetase
BF35_4481	COG1695	Transcriptional regulator
BF35_4485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BF35_4487	COG0737	Belongs to the 5'-nucleotidase family
BF35_4488	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF35_4490	COG3639	organic phosphonate transmembrane transporter activity
BF35_4495	COG1132	(ABC) transporter
BF35_4496	COG1132	(ABC) transporter
BF35_4499	COG5632	N-Acetylmuramoyl-L-alanine amidase
BF35_4499	COG3409	Peptidoglycan-binding domain 1 protein
BF35_45	COG1051	belongs to the nudix hydrolase family
BF35_4501	COG0730	response to heat
BF35_4504	COG1346	cytolysis
BF35_4506	COG0583	DNA-binding transcription factor activity
BF35_4508	COG1131	(ABC) transporter
BF35_451	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BF35_4512	COG0785	Cytochrome C biogenesis protein
BF35_4513	COG4846	Membrane protein involved in cytochrome C biogenesis
BF35_4520	COG2226	methyltransferase
BF35_4525	COG0010	Belongs to the arginase family
BF35_4526	COG1329	Transcriptional regulator
BF35_4527	COG1902	pentaerythritol trinitrate reductase activity
BF35_4528	COG0069	glutamate synthase activity
BF35_4530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BF35_4531	COG0346	lactoylglutathione lyase activity
BF35_4532	COG0400	carboxylic ester hydrolase activity
BF35_4533	COG5002	protein histidine kinase activity
BF35_4535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF35_4545	COG1396	sequence-specific DNA binding
BF35_4548	COG0318	PFAM AMP-dependent synthetase and ligase
BF35_4549	COG1268	BioY protein
BF35_4550	COG0318	PFAM AMP-dependent synthetase and ligase
BF35_4551	COG0183	Belongs to the thiolase family
BF35_4554	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BF35_4556	COG2211	Major facilitator Superfamily
BF35_4560	COG0726	polysaccharide deacetylase
BF35_4562	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BF35_4563	COG2274	protein secretion by the type I secretion system
BF35_4565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF35_4572	COG0824	Thioesterase
BF35_4573	COG4841	protein insertion into membrane
BF35_4577	COG0745	RESPONSE REGULATOR receiver
BF35_4578	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BF35_4579	COG1832	CoA-binding protein
BF35_4580	COG0187	DNA topoisomerase II activity
BF35_4581	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BF35_4582	COG0673	inositol 2-dehydrogenase activity
BF35_4586	COG1131	(ABC) transporter
BF35_4589	COG1595	DNA-templated transcription, initiation
BF35_459	COG1595	DNA-templated transcription, initiation
BF35_4591	COG1316	TRANSCRIPTIONal
BF35_4592	COG1301	dicarboxylic acid transport
BF35_4593	COG4166	transmembrane transport
BF35_4594	COG4166	transmembrane transport
BF35_4595	COG4166	transmembrane transport
BF35_4596	COG2226	methyltransferase
BF35_46	COG0592	DNA-directed DNA polymerase activity
BF35_4604	COG0531	amino acid
BF35_4607	COG0697	spore germination
BF35_4608	COG3383	formate dehydrogenase (NAD+) activity
BF35_4609	COG2427	Protein of unknown function (DUF1641)
BF35_4610	COG5609	conserved protein (DUF2294)
BF35_4611	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BF35_4613	COG2116	formate transmembrane transporter activity
BF35_4614	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BF35_4615	COG0303	'Molybdopterin
BF35_4616	COG0314	molybdopterin synthase activity
BF35_4618	COG0489	protein tyrosine kinase activity
BF35_4621	COG3326	Membrane
BF35_4622	COG2962	Rard protein
BF35_4623	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BF35_4624	COG1657	PFAM Prenyltransferase squalene oxidase
BF35_4626	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_4627	COG1012	belongs to the aldehyde dehydrogenase family
BF35_4629	COG4145	pantothenate transmembrane transporter activity
BF35_4632	COG0165	Argininosuccinate lyase
BF35_4634	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_4637	COG0494	nUDIX hydrolase
BF35_4639	COG0716	FMN binding
BF35_4641	COG1278	Cold shock
BF35_4649	COG2963	transposase activity
BF35_4650	COG2801	Transposase and inactivated derivatives
BF35_4651	COG2514	catechol 2,3-dioxygenase activity
BF35_4654	COG1285	pathogenesis
BF35_4656	COG3852	Histidine kinase
BF35_4662	COG1309	transcriptional regulator
BF35_4665	COG0825	malonyl-CoA metabolic process
BF35_4669	COG0277	FAD linked oxidase domain protein
BF35_4670	COG0385	Bile acid
BF35_4672	COG0457	Tetratricopeptide repeat
BF35_4675	COG0604	alcohol dehydrogenase
BF35_4676	COG0640	Transcriptional regulator
BF35_4678	COG0584	glycerophosphoryl diester phosphodiesterase
BF35_4684	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BF35_4690	COG1164	Oligoendopeptidase f
BF35_4691	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BF35_4694	COG1193	negative regulation of DNA recombination
BF35_4697	COG2890	protein-(glutamine-N5) methyltransferase activity
BF35_4699	COG0583	DNA-binding transcription factor activity
BF35_47	COG2816	NAD+ diphosphatase activity
BF35_4702	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF35_4706	COG3739	integral membrane protein
BF35_4707	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF35_4708	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF35_4709	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF35_471	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF35_4712	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BF35_4713	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BF35_472	COG0671	phosphoesterase, PA-phosphatase related
BF35_4720	COG2814	Major facilitator Superfamily
BF35_4721	COG1113	amino acid transport
BF35_4723	COG1695	Transcriptional regulator
BF35_473	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BF35_4732	COG2072	flavoprotein involved in K transport
BF35_4739	COG3409	Peptidoglycan-binding domain 1 protein
BF35_4739	COG3757	hydrolase, family 25
BF35_474	COG4326	sporulation control protein
BF35_4742	COG1151	hydroxylamine reductase activity
BF35_4748	COG3152	Membrane
BF35_475	COG4991	sh3 domain protein
BF35_475	COG3064	Membrane
BF35_475	COG0515	serine threonine protein kinase
BF35_4752	COG1280	lysine exporter protein (LysE YggA)
BF35_4754	COG1191	sigma factor activity
BF35_4756	COG0726	polysaccharide deacetylase
BF35_4760	COG1733	regulation of RNA biosynthetic process
BF35_4761	COG2249	NAD(P)H dehydrogenase (quinone) activity
BF35_4762	COG0318	PFAM AMP-dependent synthetase and ligase
BF35_4768	COG0384	phenazine biosynthesis protein PhzF
BF35_4772	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF35_4775	COG0673	inositol 2-dehydrogenase activity
BF35_4776	COG2188	Transcriptional regulator
BF35_4777	COG1393	Belongs to the ArsC family
BF35_4781	COG0814	amino acid
BF35_4785	COG0604	alcohol dehydrogenase
BF35_4785	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_4785	COG3321	synthase
BF35_4786	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BF35_4788	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BF35_4789	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BF35_4791	COG1070	Carbohydrate kinase
BF35_4792	COG2706	6-phosphogluconolactonase activity
BF35_4793	COG3813	Protein conserved in bacteria
BF35_4794	COG1357	PFAM Pentapeptide repeats (8 copies)
BF35_4795	COG0697	spore germination
BF35_4800	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BF35_4802	COG0789	Transcriptional regulator
BF35_4803	COG1253	flavin adenine dinucleotide binding
BF35_4810	COG0477	Major facilitator Superfamily
BF35_4812	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BF35_4816	COG0628	permease
BF35_4818	COG0180	Tryptophanyl-tRNA synthetase
BF35_482	COG1509	lysine 2,3-aminomutase activity
BF35_4820	COG1136	(ABC) transporter
BF35_4820	COG0577	efflux transmembrane transporter activity
BF35_4822	COG0110	maltose O-acetyltransferase activity
BF35_4823	COG1940	carbohydrate kinase activity
BF35_4824	COG0346	lactoylglutathione lyase activity
BF35_483	COG3829	transcription factor binding
BF35_4832	COG1011	Hydrolase
BF35_4837	COG1131	(ABC) transporter
BF35_4839	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_484	COG0456	acetyltransferase
BF35_4843	COG0778	Nitroreductase
BF35_4844	COG1733	regulation of RNA biosynthetic process
BF35_4848	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BF35_485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BF35_4850	COG3620	sequence-specific DNA binding
BF35_4853	COG2356	endonuclease I
BF35_4854	COG1288	antiporter activity
BF35_4855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BF35_4858	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BF35_486	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BF35_4866	COG2031	fatty acid transporter
BF35_487	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BF35_4870	COG2814	Major facilitator Superfamily
BF35_4871	COG1846	Transcriptional regulator
BF35_4874	COG0477	Major facilitator Superfamily
BF35_4876	COG2843	Capsule synthesis protein
BF35_4877	COG1876	peptidase activity
BF35_488	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BF35_4884	COG5632	N-Acetylmuramoyl-L-alanine amidase
BF35_4884	COG3409	Peptidoglycan-binding domain 1 protein
BF35_4887	COG2207	Transcriptional regulator
BF35_4887	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF35_4888	COG0662	Cupin 2, conserved barrel domain protein
BF35_4892	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BF35_4895	COG0531	amino acid
BF35_4896	COG1522	sequence-specific DNA binding
BF35_4897	COG1335	isochorismatase
BF35_4899	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BF35_4900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BF35_4901	COG1760	l-serine dehydratase
BF35_4902	COG1760	l-serine dehydratase
BF35_4903	COG0814	amino acid
BF35_4904	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF35_491	COG5506	Protein of unknown function (DUF1694)
BF35_4915	COG0457	Tetratricopeptide repeat
BF35_4916	COG1609	Transcriptional regulator
BF35_4917	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BF35_4918	COG0561	phosphatase activity
BF35_4919	COG0673	inositol 2-dehydrogenase activity
BF35_492	COG1012	belongs to the aldehyde dehydrogenase family
BF35_4920	COG0738	Major facilitator superfamily
BF35_4922	COG1619	proteins homologs of microcin C7 resistance protein MccF
BF35_4925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF35_4926	COG2808	Putative FMN-binding domain
BF35_4927	COG0456	acetyltransferase
BF35_4928	COG1846	Transcriptional regulator
BF35_4929	COG2364	Membrane
BF35_493	COG1253	flavin adenine dinucleotide binding
BF35_4931	COG3850	Histidine kinase
BF35_4931	COG5002	protein histidine kinase activity
BF35_4934	COG0577	efflux transmembrane transporter activity
BF35_4938	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BF35_4943	COG1476	TRANSCRIPTIONal
BF35_4947	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BF35_4957	COG2814	Major facilitator Superfamily
BF35_4965	COG2169	Transcriptional regulator
BF35_4969	COG0346	lactoylglutathione lyase activity
BF35_4972	COG1522	sequence-specific DNA binding
BF35_4973	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_4975	COG3320	Male sterility
BF35_4975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BF35_4976	COG2814	Major facilitator Superfamily
BF35_4988	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BF35_4990	COG0640	Transcriptional regulator
BF35_4991	COG0346	lactoylglutathione lyase activity
BF35_4992	COG0798	PFAM Bile acid sodium symporter
BF35_4998	COG1575	Belongs to the MenA family. Type 1 subfamily
BF35_5	COG0697	spore germination
BF35_50	COG2223	nitrite transmembrane transporter activity
BF35_500	COG1174	glycine betaine transport
BF35_5000	COG5609	conserved protein (DUF2294)
BF35_5001	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BF35_5003	COG0288	reversible hydration of carbon dioxide
BF35_5004	COG0657	acetylesterase activity
BF35_5006	COG2814	Major facilitator Superfamily
BF35_5008	COG0415	Belongs to the DNA photolyase family
BF35_501	COG1125	glycine betaine transport
BF35_501	COG0517	IMP dehydrogenase activity
BF35_5020	COG0598	Magnesium transport protein CorA
BF35_5027	COG0583	DNA-binding transcription factor activity
BF35_5031	COG1335	isochorismatase
BF35_5032	COG2267	carboxylic ester hydrolase activity
BF35_5033	COG0737	Belongs to the 5'-nucleotidase family
BF35_5039	COG1115	amino acid carrier protein
BF35_5041	COG2066	Belongs to the glutaminase family
BF35_5042	COG4191	Histidine kinase
BF35_5043	COG0784	Response regulator, receiver
BF35_5044	COG0697	spore germination
BF35_5045	COG0531	amino acid
BF35_5047	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BF35_5048	COG0531	amino acid
BF35_5049	COG0322	excinuclease ABC activity
BF35_5050	COG2207	Transcriptional regulator
BF35_5055	COG5002	protein histidine kinase activity
BF35_5059	COG1396	sequence-specific DNA binding
BF35_5060	COG0252	asparaginase activity
BF35_5061	COG1027	Aspartate ammonia-lyase
BF35_5063	COG1063	alcohol dehydrogenase
BF35_5069	COG1113	amino acid transport
BF35_5070	COG1280	lysine exporter protein (LysE YggA)
BF35_5071	COG3403	YqcI/YcgG family
BF35_5073	COG5577	PFAM Coat F domain
BF35_5074	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF35_5076	COG0574	Belongs to the PEP-utilizing enzyme family
BF35_5076	COG3848	Pyruvate phosphate dikinase
BF35_5079	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BF35_508	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BF35_5086	COG1960	acyl-CoA dehydrogenase activity
BF35_5088	COG0640	Transcriptional regulator
BF35_5089	COG0860	N-Acetylmuramoyl-L-alanine amidase
BF35_5092	COG1414	Transcriptional regulator
BF35_5093	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BF35_5094	COG1984	allophanate hydrolase subunit 2
BF35_5099	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BF35_5109	COG4335	DNA alkylation repair
BF35_5111	COG0833	amino acid
BF35_5113	COG0730	response to heat
BF35_5124	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BF35_5125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF35_5129	COG0456	acetyltransferase
BF35_5135	COG1136	(ABC) transporter
BF35_5137	COG3831	ATPase activity
BF35_5137	COG4884	unkown
BF35_514	COG1064	alcohol dehydrogenase
BF35_5142	COG1846	Transcriptional regulator
BF35_5143	COG0778	Nitroreductase
BF35_5147	COG0659	secondary active sulfate transmembrane transporter activity
BF35_5148	COG2824	Alkylphosphonate utilization operon protein PhnA
BF35_5150	COG0714	Associated with various cellular activities
BF35_5155	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BF35_5157	COG0753	catalase activity
BF35_5158	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BF35_5160	COG0463	Glycosyl transferase, family 2
BF35_5163	COG0463	Glycosyl transferase, family 2
BF35_5168	COG0714	Associated with various cellular activities
BF35_517	COG2197	response regulator
BF35_5173	COG0346	lactoylglutathione lyase activity
BF35_5179	COG4377	Putative membrane peptidase family (DUF2324)
BF35_518	COG4585	Histidine kinase
BF35_518	COG2203	Gaf domain
BF35_5182	COG3655	Transcriptional regulator
BF35_5184	COG1785	Belongs to the alkaline phosphatase family
BF35_5186	COG3239	Fatty acid desaturase
BF35_5187	COG1690	Belongs to the RtcB family
BF35_5188	COG0833	amino acid
BF35_5189	COG1414	Transcriptional regulator
BF35_519	COG0668	transmembrane transport
BF35_5190	COG4187	Peptidase family M20/M25/M40
BF35_5191	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BF35_5194	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BF35_5198	COG2329	Antibiotic biosynthesis monooxygenase
BF35_5205	COG1070	Carbohydrate kinase
BF35_5206	COG2390	Transcriptional regulator
BF35_5208	COG1172	Belongs to the binding-protein-dependent transport system permease family
BF35_5209	COG1172	Belongs to the binding-protein-dependent transport system permease family
BF35_5210	COG1879	ABC-type sugar transport system periplasmic component
BF35_5216	COG1388	LysM domain
BF35_5216	COG3584	3D domain protein
BF35_522	COG1335	isochorismatase
BF35_5221	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BF35_5221	COG1605	Chorismate mutase
BF35_5223	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BF35_5224	COG0287	Prephenate dehydrogenase
BF35_5227	COG1309	transcriptional regulator
BF35_5228	COG1033	growth of symbiont in host cell
BF35_5228	COG2409	Drug exporters of the RND superfamily
BF35_5230	COG0488	(ABC) transporter
BF35_5231	COG1368	sulfuric ester hydrolase activity
BF35_5232	COG0861	Integral membrane protein TerC family
BF35_5233	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BF35_5235	COG3037	sugar-specific permease SgaT UlaA
BF35_5237	COG0726	polysaccharide deacetylase
BF35_5238	COG0346	lactoylglutathione lyase activity
BF35_5244	COG2318	DinB family
BF35_5245	COG0697	spore germination
BF35_5249	COG2746	aminoglycoside 3-N-acetyltransferase activity
BF35_525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BF35_5253	COG2816	NAD+ diphosphatase activity
BF35_5256	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BF35_5257	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BF35_5258	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BF35_526	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF35_5260	COG0628	permease
BF35_5269	COG1131	(ABC) transporter
BF35_5272	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BF35_5274	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BF35_5275	COG0436	Aminotransferase
BF35_5282	COG2226	methyltransferase
BF35_5285	COG2261	transglycosylase associated protein
BF35_5289	COG0477	Major facilitator Superfamily
BF35_5289	COG2814	Major facilitator Superfamily
BF35_5290	COG4533	DNA binding
BF35_5291	COG0789	Transcriptional regulator
BF35_5292	COG1664	Polymer-forming cytoskeletal
BF35_5294	COG2814	Major facilitator Superfamily
BF35_530	COG0367	asparagine synthase
BF35_5303	COG1307	EDD domain protein, DegV family
BF35_5304	COG1164	Oligoendopeptidase f
BF35_531	COG0071	Belongs to the small heat shock protein (HSP20) family
BF35_5312	COG0745	RESPONSE REGULATOR receiver
BF35_5313	COG3850	Histidine kinase
BF35_5313	COG5002	protein histidine kinase activity
BF35_5314	COG2936	dipeptidyl-peptidase activity
BF35_532	COG1999	signal sequence binding
BF35_5323	COG4948	Mandelate Racemase Muconate Lactonizing
BF35_5325	COG4166	transmembrane transport
BF35_5329	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BF35_533	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BF35_5332	COG0586	Pfam SNARE associated Golgi protein
BF35_534	COG1307	EDD domain protein, DegV family
BF35_5341	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BF35_5342	COG3938	Belongs to the proline racemase family
BF35_5344	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BF35_5345	COG1012	belongs to the aldehyde dehydrogenase family
BF35_5346	COG1115	amino acid carrier protein
BF35_5347	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BF35_5350	COG3397	chitin binding
BF35_5355	COG4637	Psort location Cytoplasmic, score
BF35_536	COG0805	protein transport
BF35_5360	COG0514	ATP-dependent DNA helicase (RecQ)
BF35_5361	COG2105	PFAM AIG2 family protein
BF35_5364	COG3973	AAA domain
BF35_5373	COG2963	transposase activity
BF35_5374	COG2801	Transposase and inactivated derivatives
BF35_5376	COG0658	competence protein
BF35_5376	COG2333	competence protein COMEC
BF35_5378	COG2315	Protein conserved in bacteria
BF35_5379	COG2226	methyltransferase
BF35_538	COG1272	protein, Hemolysin III
BF35_5380	COG2205	protein histidine kinase activity
BF35_5384	COG1819	glycosyl
BF35_5385	COG3397	chitin binding
BF35_5386	COG2153	protein acetylation
BF35_539	COG0204	Acyl-transferase
BF35_5392	COG0517	IMP dehydrogenase activity
BF35_5392	COG4175	Glycine betaine
BF35_5394	COG4176	ABC-type proline glycine betaine transport system permease component
BF35_5401	COG0456	acetyltransferase
BF35_5401	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BF35_5402	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_5404	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BF35_5405	COG0022	dehydrogenase e1 component
BF35_5406	COG0508	dehydrogenase complex catalyzes the overall conversion of
BF35_5407	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BF35_541	COG0768	penicillin binding
BF35_5411	COG1349	DNA-binding transcription factor activity
BF35_5415	COG3284	Transcriptional regulator
BF35_5419	COG1309	transcriptional regulator
BF35_5426	COG3409	Peptidoglycan-binding domain 1 protein
BF35_5426	COG3773	Cell wall hydrolase
BF35_5427	COG2959	enzyme of heme biosynthesis
BF35_5430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF35_5447	COG3620	sequence-specific DNA binding
BF35_5449	COG0582	viral genome integration into host DNA
BF35_545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BF35_5451	COG1192	Involved in chromosome partitioning
BF35_5454	COG1136	(ABC) transporter
BF35_549	COG0546	phosphoglycolate phosphatase activity
BF35_551	COG4473	ABC transporter
BF35_552	COG1131	(ABC) transporter
BF35_554	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BF35_555	COG0456	acetyltransferase
BF35_557	COG1794	racemase activity, acting on amino acids and derivatives
BF35_558	COG1454	alcohol dehydrogenase
BF35_559	COG2610	gluconate transmembrane transporter activity
BF35_564	COG0733	neurotransmitter:sodium symporter activity
BF35_578	COG1674	ftsk spoiiie
BF35_58	COG0697	spore germination
BF35_582	COG0017	Asparaginyl-tRNA synthetase
BF35_59	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF35_593	COG2521	methyltransferase
BF35_593	COG2136	Putative SAM-dependent methyltransferase
BF35_596	COG1413	lyase activity
BF35_597	COG0629	single-stranded DNA binding
BF35_600	COG0488	(ABC) transporter
BF35_601	COG1418	mRNA catabolic process
BF35_604	COG5632	N-Acetylmuramoyl-L-alanine amidase
BF35_607	COG2359	stage V sporulation protein S
BF35_612	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
BF35_613	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BF35_614	COG2146	nitrite reductase [NAD(P)H] activity
BF35_615	COG1587	Uroporphyrinogen-III synthase
BF35_615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BF35_617	COG1648	precorrin-2 dehydrogenase activity
BF35_62	COG0584	glycerophosphoryl diester phosphodiesterase
BF35_621	COG2223	nitrite transmembrane transporter activity
BF35_623	COG0314	molybdopterin synthase activity
BF35_624	COG0303	'Molybdopterin
BF35_625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BF35_626	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BF35_627	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BF35_628	COG2181	nitrate reductase activity
BF35_629	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BF35_630	COG1140	nitrate reductase beta subunit
BF35_631	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BF35_634	COG0714	Associated with various cellular activities
BF35_637	COG1305	Transglutaminase-like
BF35_638	COG0386	Belongs to the glutathione peroxidase family
BF35_640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BF35_640	COG0426	domain, Protein
BF35_644	COG1595	DNA-templated transcription, initiation
BF35_645	COG0604	alcohol dehydrogenase
BF35_647	COG0346	lactoylglutathione lyase activity
BF35_652	COG2226	methyltransferase
BF35_657	COG3874	Sporulation protein YtfJ
BF35_66	COG2814	Major facilitator Superfamily
BF35_665	COG0456	acetyltransferase
BF35_671	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF35_672	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF35_673	COG1819	glycosyl
BF35_677	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BF35_679	COG0561	phosphatase activity
BF35_68	COG0693	protein deglycase activity
BF35_681	COG1942	4-Oxalocrotonate Tautomerase
BF35_687	COG0251	oxidation-reduction process
BF35_690	COG0196	riboflavin kinase activity
BF35_692	COG2368	4-hydroxyphenylacetate
BF35_695	COG2211	Major facilitator Superfamily
BF35_696	COG0154	amidase activity
BF35_697	COG0494	nUDIX hydrolase
BF35_698	COG1876	peptidase activity
BF35_7	COG0201	protein transport
BF35_700	COG0860	N-Acetylmuramoyl-L-alanine amidase
BF35_703	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BF35_704	COG1114	Component of the transport system for branched-chain amino acids
BF35_705	COG2801	Transposase and inactivated derivatives
BF35_706	COG2963	transposase activity
BF35_709	COG1253	flavin adenine dinucleotide binding
BF35_710	COG2839	Protein conserved in bacteria
BF35_711	COG0702	epimerase
BF35_714	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BF35_715	COG1607	acyl-coa hydrolase
BF35_716	COG3689	TIGRFAM TIGR03943 family protein
BF35_717	COG0701	Predicted permease
BF35_719	COG2244	polysaccharide biosynthetic process
BF35_720	COG0586	Pfam SNARE associated Golgi protein
BF35_721	COG1051	belongs to the nudix hydrolase family
BF35_722	COG5337	Spore coat protein CotH
BF35_724	COG0406	alpha-ribazole phosphatase activity
BF35_727	COG4166	transmembrane transport
BF35_729	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BF35_731	COG0702	epimerase
BF35_733	COG3443	Belongs to the bacterial solute-binding protein 9 family
BF35_733	COG0803	Belongs to the bacterial solute-binding protein 9 family
BF35_734	COG0456	acetyltransferase
BF35_735	COG0523	cobalamin synthesis protein
BF35_736	COG4989	oxidoreductase activity
BF35_737	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF35_738	COG1231	oxidoreductase activity
BF35_740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BF35_743	COG0783	Belongs to the Dps family
BF35_744	COG3949	Membrane
BF35_751	COG2814	Major facilitator Superfamily
BF35_752	COG0667	Aldo Keto reductase
BF35_753	COG0640	Transcriptional regulator
BF35_754	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BF35_755	COG1404	Belongs to the peptidase S8 family
BF35_756	COG2002	toxin-antitoxin pair type II binding
BF35_757	COG0577	efflux transmembrane transporter activity
BF35_764	COG1752	Esterase of the alpha-beta hydrolase superfamily
BF35_766	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF35_767	COG1279	arginine transmembrane transporter activity
BF35_768	COG2814	Major facilitator Superfamily
BF35_77	COG1028	Short-chain dehydrogenase reductase Sdr
BF35_770	COG1082	Xylose isomerase domain protein TIM barrel
BF35_773	COG0318	PFAM AMP-dependent synthetase and ligase
BF35_774	COG4264	IucA IucC family
BF35_776	COG1247	-acetyltransferase
BF35_777	COG1285	pathogenesis
BF35_779	COG0726	polysaccharide deacetylase
BF35_780	COG5002	protein histidine kinase activity
BF35_781	COG0745	RESPONSE REGULATOR receiver
BF35_783	COG1316	TRANSCRIPTIONal
BF35_788	COG0460	homoserine dehydrogenase
BF35_792	COG0726	polysaccharide deacetylase
BF35_795	COG0300	oxidoreductase activity
BF35_797	COG5002	protein histidine kinase activity
BF35_798	COG0745	RESPONSE REGULATOR receiver
BF35_799	COG1132	(ABC) transporter
BF35_80	COG0671	phosphoesterase, PA-phosphatase related
BF35_801	COG0791	NLP P60 protein
BF35_801	COG1388	LysM domain
BF35_804	COG1686	Belongs to the peptidase S11 family
BF35_81	COG0604	alcohol dehydrogenase
BF35_810	COG1216	Glycosyl transferase, family 2
BF35_812	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BF35_813	COG4988	ABC transporter
BF35_814	COG1294	oxidase, subunit
BF35_815	COG1271	oxidase subunit
BF35_819	COG1942	4-Oxalocrotonate Tautomerase
BF35_82	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BF35_821	COG0583	DNA-binding transcription factor activity
BF35_825	COG0411	ABC transporter
BF35_828	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF35_829	COG2030	dehydratase
BF35_830	COG0318	PFAM AMP-dependent synthetase and ligase
BF35_832	COG0523	cobalamin synthesis protein
BF35_833	COG1231	oxidoreductase activity
BF35_834	COG0039	L-malate dehydrogenase activity
BF35_835	COG0628	permease
BF35_838	COG0778	Nitroreductase
BF35_839	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BF35_84	COG2205	protein histidine kinase activity
BF35_840	COG1959	2 iron, 2 sulfur cluster binding
BF35_841	COG0583	DNA-binding transcription factor activity
BF35_842	COG0697	spore germination
BF35_843	COG4549	nuclear export factor GLE1
BF35_844	COG1276	copper resistance
BF35_844	COG2372	response to copper ion
BF35_846	COG1114	Component of the transport system for branched-chain amino acids
BF35_853	COG2132	Multicopper oxidase
BF35_854	COG0006	proline dipeptidase activity
BF35_856	COG4846	Membrane protein involved in cytochrome C biogenesis
BF35_859	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BF35_860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BF35_862	COG2390	Transcriptional regulator
BF35_863	COG1309	transcriptional regulator
BF35_870	COG0531	amino acid
BF35_872	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BF35_875	COG1914	H( )-stimulated, divalent metal cation uptake system
BF35_880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF35_884	COG4166	transmembrane transport
BF35_89	COG1794	racemase activity, acting on amino acids and derivatives
BF35_892	COG0427	acetyl-CoA hydrolase
BF35_893	COG3279	Response regulator of the LytR AlgR family
BF35_896	COG3384	dioxygenase
BF35_897	COG2814	Major facilitator Superfamily
BF35_9	COG1523	belongs to the glycosyl hydrolase 13 family
BF35_90	COG1819	glycosyl
BF35_902	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BF35_906	COG0028	Belongs to the TPP enzyme family
BF35_907	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BF35_908	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BF35_91	COG5002	protein histidine kinase activity
BF35_912	COG2323	membrane
BF35_913	COG5566	PFAM Mor transcription activator
BF35_915	COG0733	neurotransmitter:sodium symporter activity
BF35_916	COG2244	polysaccharide biosynthetic process
BF35_919	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BF35_92	COG0561	phosphatase activity
BF35_920	COG2223	nitrite transmembrane transporter activity
BF35_921	COG4166	transmembrane transport
BF35_922	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BF35_924	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF35_925	COG0477	Major facilitator Superfamily
BF35_934	COG1051	belongs to the nudix hydrolase family
BF35_940	COG3620	sequence-specific DNA binding
BF35_943	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BF35_944	COG0784	Response regulator, receiver
BF35_945	COG4191	Histidine kinase
BF35_946	COG0281	malic enzyme
BF35_947	COG1027	Aspartate ammonia-lyase
BF35_949	COG0528	UMP kinase activity
BF35_950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BF35_953	COG1131	(ABC) transporter
BF35_960	COG2733	membrane
BF35_965	COG0785	Cytochrome C biogenesis protein
BF35_969	COG3340	Belongs to the peptidase S51 family
BF35_970	COG0534	Mate efflux family protein
BF35_972	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF35_974	COG0114	fumarate hydratase activity
BF35_975	COG4221	oxidoreductase activity
BF35_976	COG0789	Transcriptional regulator
BF35_977	COG1757	Na H antiporter
BF35_978	COG1216	Glycosyl transferase, family 2
BF35_978	COG0438	transferase activity, transferring glycosyl groups
BF35_980	COG0701	Predicted permease
BF35_981	COG0523	cobalamin synthesis protein
BF35_982	COG0697	spore germination
BF35_983	COG1802	Transcriptional regulator
BF35_989	COG0367	asparagine synthase
BF35_99	COG2124	cytochrome p450
BF35_991	COG1846	Transcriptional regulator
BF35_997	COG1686	Belongs to the peptidase S11 family