locus-tag class description WR51_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) WR51_00015 ENOG410848D S4 domain protein YaaA WR51_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WR51_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) WR51_00080 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) WR51_00100 ENOG4105ZMH deoxynucleoside kinase WR51_00110 ENOG4105GTG Isochorismatase WR51_00120 ENOG4108Z6B deaminase WR51_00125 ENOG4105C6E dna polymerase iii WR51_00145 ENOG41067KS pro-sigma K processing WR51_00180 ENOG4105CXN decarboxylase WR51_00190 ENOG4105FA2 dna polymerase iii WR51_00195 ENOG4105MA4 psp1 domain protein WR51_00205 ENOG41060K3 Methyltransferase WR51_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) WR51_00220 ENOG4105KRN Transcriptional regulator, abrb family WR51_00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) WR51_00230 ENOG4105F8V Hydrolase, tatD family WR51_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) WR51_00245 ENOG4105XFA sporulation peptidase YabG WR51_00250 ENOG4105W42 Veg protein WR51_00265 ENOG4105DFT pur operon repressor WR51_00270 ENOG4105KME endoribonuclease L-psp WR51_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase WR51_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) WR51_00300 ENOG4108JA2 transcriptioN-repair coupling factor WR51_00305 ENOG4108M14 stage v sporulation protein t WR51_00315 ENOG4108IY2 MazG family WR51_00320 ENOG41082I2 s4 domain protein WR51_00325 ENOG4105VYY sporulation protein yabp WR51_00340 ENOG41060GV RNA binding s1 domain protein WR51_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) WR51_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase WR51_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) WR51_00385 ENOG4105C6T cysteine synthase WR51_00390 ENOG4105CRQ synthase (Component I) WR51_00395 ENOG4105DDQ anthranilate synthase WR51_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 WR51_00405 ENOG4105EEI dihydropteroate synthase WR51_00410 ENOG4105KRF dihydroneopterin aldolase WR51_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase WR51_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) WR51_00515 ENOG4108Z0C Uvrb UvrC protein WR51_00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) WR51_00540 ENOG4105CTP PilT protein domain protein WR51_00560 ENOG4105D7W serine acetyltransferase WR51_00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 WR51_00580 ENOG4105M0M Tetracycline resistance protein WR51_00585 ENOG4105QIV RNA polymerase WR51_00600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) WR51_00620 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) WR51_00625 ENOG4107Y49 methyltransferase WR51_00635 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WR51_00640 ENOG4105XPM ribosomal protein WR51_00745 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) WR51_00770 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) WR51_00780 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) WR51_00790 ENOG41067V7 50S ribosomal protein L36 WR51_00815 ENOG4108JJB ABC transporter WR51_00820 ENOG4108JJB ABC transporter WR51_00825 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) WR51_00830 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) WR51_00855 ENOG4105D1F ATP-binding protein WR51_00870 ENOG4108NMV polysaccharide deacetylase WR51_00950 ENOG4105C8B TIGR00159 family WR51_00955 ENOG4107U5W ybbr family WR51_00970 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) WR51_00995 ENOG4108PSK reductase WR51_01000 ENOG4108UMI ABC transporter, permease WR51_01005 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WR51_01010 ENOG4105D01 (LipO)protein WR51_01015 ENOG4105CB2 alcohol dehydrogenase WR51_01025 ENOG4105IQ5 FAD linked oxidase domain protein WR51_01040 ENOG4105C2C drug resistance transporter, Bcr CflA WR51_01060 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WR51_01065 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WR51_01070 ENOG4105C3U ABC transporter WR51_01075 ENOG4108JQ7 (ABC) transporter WR51_01095 ENOG4108J59 Extracellular solute-binding protein, family 5 WR51_01100 ENOG4108J59 Extracellular solute-binding protein, family 5 WR51_01120 ENOG4106Z1T Nicotinamide Mononucleotide Transporter WR51_01130 ENOG4105E0C molybdate abc transporter WR51_01135 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein WR51_01140 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family WR51_01175 ENOG4105F6E Acyl-transferase WR51_01195 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) WR51_01215 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) WR51_01240 ENOG4105C5H ABC transporter WR51_01250 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein WR51_01260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WR51_01265 ENOG4105C3U ABC transporter WR51_01270 ENOG4108JQ7 (ABC) transporter WR51_01275 ENOG410667J hydrolase WR51_01305 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase WR51_01310 ENOG4105ERH Fumarylacetoacetate hydrolase WR51_01320 ENOG4105CUB amino acid WR51_01325 ENOG4108SC4 )-transporter WR51_01330 ENOG4105CPF Cell wall formation (By similarity) WR51_01335 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) WR51_01360 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein WR51_01365 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) WR51_01375 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) WR51_01480 ENOG4105K8N protein family UPF0079, ATPase WR51_01485 ENOG41072GX Peptidase M22 Glycoprotease WR51_01490 ENOG410801F ribosomal-protein-alanine acetyltransferase WR51_01495 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WR51_01500 ENOG4105C5H ABC transporter WR51_01515 ENOG4108TYN CAAX amino terminal protease family protein WR51_01530 ENOG4108IBT Inherit from COG: transposase WR51_01545 ENOG4105C7N Xanthine uracil vitamin C permease WR51_01555 ENOG4105BZU Histidine kinase WR51_01580 ENOG4107ZXU DSBA oxidoreductase WR51_01600 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR51_01655 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR51_01675 ENOG4105SX7 Transporter WR51_01705 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) WR51_01710 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit WR51_01715 ENOG4105C83 adenylosuccinate lyase WR51_01725 ENOG4105VR9 phosphoribosylformylglycinamidine synthase WR51_01750 ENOG4108V3E phosphoribosylglycinamide formyltransferase WR51_01760 ENOG4105C12 Phosphoribosylglycinamide synthetase WR51_01770 ENOG4105EGI Transcriptional regulator WR51_01795 ENOG4105C4R Atp-dependent dna helicase WR51_01800 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) WR51_01820 ENOG4108W2Y isochorismatase WR51_01830 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WR51_01835 ENOG4108UMI ABC transporter, permease WR51_01840 ENOG4105D01 (LipO)protein WR51_01860 ENOG410834F Transcriptional regulator WR51_01865 ENOG4107I77 yiaA/B two helix domain WR51_01885 ENOG4105CBD Diacylglycerol kinase WR51_01895 ENOG4108JPW Aminotransferase WR51_01905 ENOG4105C26 Dehydrogenase WR51_01910 ENOG4105KPY Small multidrug resistance protein WR51_01930 ENOG4105D9N nucleoside WR51_01935 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) WR51_01945 ENOG4108W15 Protein of unknown function (DUF1456) WR51_01960 ENOG4105DTQ mandelate racemase muconate lactonizing WR51_01970 ENOG4105DFD Na H antiporter WR51_01995 ENOG4105D3R alkyl hydroperoxide reductase WR51_02000 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) WR51_02005 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) WR51_02010 ENOG4107W7X Aldolase WR51_02015 ENOG4105EHG Permease protein WR51_02020 ENOG4105DQ5 transport system permease protein WR51_02025 ENOG4108V5C ABC transporter WR51_02035 ENOG4105CAY ferredoxin--nadp reductase WR51_02055 ENOG4106UIA WR51_02060 ENOG4106UIA WR51_02075 ENOG4105BZU Histidine kinase WR51_02095 ENOG410756H nucleotidyltransferase WR51_02100 ENOG4105D2S major facilitator superfamily WR51_02115 ENOG4105E5Q amino acid AbC transporter WR51_02120 ENOG4105EAB amino acid AbC transporter WR51_02130 ENOG4105C8Q Methyl-accepting chemotaxis WR51_02145 ENOG4105DBV ornithine carbamoyltransferase WR51_02155 ENOG4105C5B carbamate kinase WR51_02160 ENOG4108W63 CRP FNR family transcriptional regulator WR51_02170 ENOG4105DNP FAD linked oxidase domain protein WR51_02180 ENOG4105CI1 PTS System WR51_02195 ENOG4105C9U ATP-dependent DNA helicase RecQ WR51_02210 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter WR51_02230 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WR51_02235 ENOG4107Z6I Thiamine biosynthesis protein WR51_02245 ENOG4105C5H ABC transporter WR51_02275 ENOG41062JF Transcriptional regulator WR51_02290 ENOG4105DEU major facilitator superfamily WR51_02305 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) WR51_02320 ENOG4108N0M stress protein WR51_02325 ENOG4106FN3 tellurium resistance protein WR51_02330 ENOG4106FN3 tellurium resistance protein WR51_02335 ENOG4107TS3 membrane protein, TerC WR51_02340 ENOG4108TTB tellurium resistance protein WR51_02355 ENOG41068PA UPF0435 protein WR51_02360 ENOG4105KJF protein tyrosine phosphatase WR51_02370 ENOG4107U9T Pfam:Ribonuclease_BN WR51_02375 ENOG4105C59 p-type ATPase WR51_02380 ENOG4108IPJ Membrane WR51_02400 ENOG4107ZTW SNARE associated Golgi WR51_02415 ENOG410606W general stress protein WR51_02420 ENOG4105UPD Calcium Proton WR51_02455 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) WR51_02460 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) WR51_02470 ENOG4108JUB Transcriptional regulator WR51_02480 ENOG4108IQI permease WR51_02520 ENOG4108A04 Beta-lactamase WR51_02535 ENOG4107R51 Glycosyl transferase, family 2 WR51_02540 ENOG4107QQG Dehydrogenase WR51_02545 ENOG4105C3I Nad-dependent epimerase dehydratase WR51_02550 ENOG4105CKK Glycosyl transferase, family 2 WR51_02565 ENOG4105F1A Pyruvate formate-lyase WR51_02585 ENOG4105CI2 imidazolone-5-propionate hydrolase WR51_02590 ENOG4105ECP epimerase WR51_02620 ENOG41067AE Membrane-bound metal-dependent hydrolase WR51_02625 ENOG4105CEN a g-specific adenine glycosylase WR51_02630 ENOG4106BXE WR51_02650 ENOG4105BZ1 (ABC) transporter WR51_02655 ENOG4107NBY Membrane WR51_02660 ENOG4105CBC glutamate synthase WR51_02670 ENOG4108IUW ABC transporter WR51_02690 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WR51_02695 ENOG4105G5W regulator Fur family WR51_02875 ENOG4108JQC penicillin-binding protein 1A WR51_02880 ENOG4108R9S DSBA oxidoreductase WR51_02890 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) WR51_02900 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) WR51_02915 ENOG4105CYN Serine protein kinase WR51_02990 ENOG4105DQ6 Transposase WR51_03015 ENOG4105C94 Transporter WR51_03030 ENOG4105DZ6 Band 7 protein WR51_03040 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism WR51_03045 ENOG4108V9W transcriptional regulatory protein WR51_03050 ENOG4105D4T Citrate transporter WR51_03075 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator WR51_03080 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WR51_03085 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component WR51_03090 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component WR51_03095 ENOG4105BZ7 extracellular solute-binding protein family 1 WR51_03100 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) WR51_03105 ENOG4108STX response regulator WR51_03110 ENOG4105US7 Histidine kinase WR51_03135 ENOG4108MRH transcriptional regulatory protein WR51_03145 ENOG4105C6K Malic enzyme WR51_03155 ENOG4108UZ3 Transporter WR51_03160 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR51_03170 ENOG4105BZU Histidine kinase WR51_03175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR51_03185 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) WR51_03190 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) WR51_03195 ENOG4108JB9 formate dehydrogenase WR51_03215 ENOG4105CUB amino acid WR51_03230 ENOG4105C59 p-type ATPase WR51_03235 ENOG4105DAP Nicotinate phosphoribosyltransferase WR51_03265 ENOG41073R8 VanW family WR51_03270 ENOG4108KGH TRANSCRIPTIONal WR51_03275 ENOG4105D9N nucleoside WR51_03280 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase WR51_03285 ENOG4105C37 (CBS) domain WR51_03290 ENOG4108IJ0 Aspartate ammonia-lyase WR51_03295 ENOG4105DAA L-lactate WR51_03310 ENOG4105DUX Transporter WR51_03315 ENOG4108MES Periplasmic binding protein WR51_03320 ENOG4105DQ5 transport system permease protein WR51_03325 ENOG4108IHU transport system permease protein WR51_03330 ENOG4105E0A ABC, transporter WR51_03345 ENOG4105EXW epimerase dehydratase WR51_03350 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) WR51_03360 ENOG4107T89 von Willebrand factor, type A WR51_03365 ENOG4105GMT ATPase associated with various cellular activities aaa_5 WR51_03370 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WR51_03380 ENOG4105BZU Histidine kinase WR51_03385 ENOG4105D5Q Arginine ornithine antiporter WR51_03390 ENOG4107414 GntR family transcriptional regulator WR51_03395 ENOG4105C5Y PTS System WR51_03400 ENOG4105CG3 alpha amylase, catalytic region WR51_03415 ENOG4105E1K spore germination protein WR51_03425 ENOG4105CRN Aminoglycoside phosphotransferase WR51_03430 ENOG4105BZG amino acid carrier protein WR51_03435 ENOG4105CDA abc transporter atp-binding protein WR51_03440 ENOG4105CT1 (ABC) transporter WR51_03445 ENOG4105EAD ABC transporter WR51_03450 ENOG4105DRP amino acid AbC transporter WR51_03455 ENOG4108IQI permease WR51_03470 ENOG4105GFR rna polymerase sigma factor WR51_03480 ENOG4105D29 Helix-turn-helix type 11 domain protein WR51_03485 ENOG4105NAE bifunctional deaminase-reductase domain protein WR51_03490 ENOG4105BZU Histidine kinase WR51_03515 ENOG4105CHH sulfate transporter WR51_03520 ENOG41068KF Universal stress protein WR51_03530 ENOG4105DEF Extracellular solute-binding protein, family 5 WR51_03540 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WR51_03545 ENOG4108JQ7 (ABC) transporter WR51_03555 ENOG4105CXY transporter WR51_03560 ENOG41067TZ transcriptional regulator, MarR family WR51_03565 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR51_03570 ENOG4105ETE Transcriptional regulator (LacI family WR51_03575 ENOG4108RVA ribokinase WR51_03585 ENOG4105C2J ABC transporter WR51_03590 ENOG4105CNN ABC, transporter WR51_03595 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator WR51_03600 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) WR51_03635 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) WR51_03665 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) WR51_03670 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer WR51_03675 ENOG41069ER domain protein WR51_03680 ENOG4105VZ8 Transcriptional regulator WR51_03685 ENOG4107D63 WR51_03700 ENOG4105DUX Transporter WR51_03720 ENOG4105C85 amino acid WR51_03725 ENOG4105C7N Xanthine uracil vitamin C permease WR51_03740 ENOG4105MA6 gCN5-related N-acetyltransferase WR51_03760 ENOG4105CCU oxidase (Subunit III) WR51_03765 ENOG4105BZ9 Cytochrome C oxidase, subunit I WR51_03770 ENOG4105E2S oxidase) subunit II WR51_03790 ENOG4106CAD Protein of unknown function (DUF3311) WR51_03795 ENOG4105E1V na solute symporter WR51_03810 ENOG4108NHD germination protein WR51_03820 ENOG4105CE1 Ferrous iron transport protein b WR51_03825 ENOG4105CE1 Ferrous iron transport protein b WR51_03830 ENOG4105CE1 Ferrous iron transport protein b WR51_03835 ENOG4105CVA phosphate WR51_03845 ENOG4105E2Z phosphate ABC transporter (Permease WR51_03975 ENOG41080XQ Signal transduction protein with cbs domains WR51_04000 ENOG4105ETU transcriptional activator (TenA WR51_04010 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WR51_04020 ENOG4108VEU Thiamine monophosphate synthase WR51_04025 ENOG41080HI glycine oxidase WR51_04040 ENOG4105D06 uba thif-type nad fad binding protein WR51_04045 ENOG4105DWF phosphomethylpyrimidine kinase WR51_04080 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) WR51_04095 ENOG4108INS Transcriptional regulator WR51_04110 ENOG4105DQ6 Transposase WR51_04120 ENOG4105C7N Xanthine uracil vitamin C permease WR51_04130 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein WR51_04145 ENOG4105K63 Thioredoxin WR51_04165 ENOG4108B31 Spore germination protein WR51_04185 ENOG4107Y03 Nitroreductase WR51_04190 ENOG4105ED1 spovr family WR51_04200 ENOG4105J4Q Transcriptional regulator WR51_04215 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase WR51_04220 ENOG4105XTG Pfam:DUF156 WR51_04225 ENOG4105VFE sira family WR51_04230 ENOG4107TPS domain protein WR51_04235 ENOG4105VFE sira family WR51_04240 ENOG41085GJ domain protein WR51_04250 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase WR51_04255 ENOG41087NI Sulfite exporter TauE/SafE WR51_04265 ENOG4108KGH TRANSCRIPTIONal WR51_04290 ENOG4105EMD TRANSCRIPTIONal WR51_04295 ENOG4105VCP PTS System WR51_04300 ENOG4105VZJ PTS System WR51_04320 ENOG41069ER domain protein WR51_04325 ENOG4107RBB ABC transporter, permease WR51_04330 ENOG4105C19 ABC transporter WR51_04360 ENOG4105WEF catalase WR51_04395 ENOG4107T5V SNARE associated Golgi WR51_04430 ENOG4105CUB amino acid WR51_04435 ENOG4107RWR Sodium hydrogen exchanger WR51_04445 ENOG4106KNT transcriptional regulator WR51_04485 ENOG4108YXU transcriptional regulator AsnC family WR51_04490 ENOG4105CH7 arginosuccinase WR51_04495 ENOG4105UBK short-chain dehydrogenase reductase WR51_04505 ENOG4105KPY Small multidrug resistance protein WR51_04545 ENOG4107RKG DJ-1/PfpI family WR51_04550 ENOG4105CH6 catalase WR51_04560 ENOG4105D5Q Arginine ornithine antiporter WR51_04565 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) WR51_04575 ENOG4105C26 Dehydrogenase WR51_04585 ENOG4105BZ1 (ABC) transporter WR51_04590 ENOG4105BZ1 (ABC) transporter WR51_04600 ENOG4105DRP amino acid AbC transporter WR51_04605 ENOG4105CDA abc transporter atp-binding protein WR51_04620 ENOG410839P WR51_04630 ENOG4108UH6 UPF0754 membrane protein WR51_04640 ENOG4105BZU Histidine kinase WR51_04645 ENOG4105WH1 Two component transcriptional regulator luxr family WR51_04660 ENOG4105D7V transposase WR51_04670 ENOG4107FQX Alpha-acetolactate decarboxylase WR51_04690 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR51_04695 ENOG4105D4P Coproporphyrinogen iii oxidase WR51_04700 ENOG4105CEY Amp-dependent synthetase and ligase WR51_04715 ENOG4105CHH sulfate transporter WR51_04740 ENOG4105CGU Enoyl-CoA hydratase WR51_04760 ENOG4105DER m42 family WR51_04780 ENOG4105CTU Proline racemase WR51_04785 ENOG4105CIF Ornithine Cyclodeaminase WR51_04805 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WR51_04815 ENOG4108JQ7 (ABC) transporter WR51_04855 ENOG4105CSH Transporter WR51_04865 ENOG4108MRH transcriptional regulatory protein WR51_04935 ENOG4105CDU Replicative dna helicase WR51_04975 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR51_04985 ENOG4105D9U N-acetyltransferase WR51_05005 ENOG4107SWG transcriptional regulator MERR family WR51_05040 ENOG4108VJ1 Transcriptional regulator (CarD family WR51_05070 ENOG4105CJ1 ABC, transporter WR51_05100 ENOG4105T09 s-layer domain-containing protein WR51_05105 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WR51_05130 ENOG4105F6J Alpha beta hydrolase fold WR51_05180 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase WR51_05195 ENOG4105F27 Major Facilitator WR51_05200 ENOG4105WAB arsR family transcriptional regulator WR51_05210 ENOG4105CMT Dihydroxyacetone kinase WR51_05220 ENOG4105CMT Dihydroxyacetone kinase WR51_05315 ENOG4105WN5 stage II sporulation protein WR51_05325 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR51_05335 ENOG4108MJI response regulator WR51_05340 ENOG4105BZU Histidine kinase WR51_05345 ENOG4105BZU Histidine kinase WR51_05385 ENOG4107QHE Choloylglycine hydrolase WR51_05405 ENOG4107VRP DNA repair exonuclease WR51_05410 ENOG4106D4I domain protein WR51_05430 ENOG410829K Lysine exporter protein (Lyse ygga) WR51_05460 ENOG4108MUZ hydrolase WR51_05475 ENOG4105F0F Oxalate decarboxylase WR51_05480 ENOG41067QW Transcriptional regulator WR51_05485 ENOG4105D7V transposase WR51_05490 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator WR51_05505 ENOG4105C6V Glycerol-3-phosphate dehydrogenase WR51_05515 ENOG4105DU6 RNA polymerase WR51_05525 ENOG4105CNI cell division protein FtsW WR51_05530 ENOG4105EEM helicase WR51_05535 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WR51_05565 ENOG4105K59 histidine triad (HIT) protein WR51_05635 ENOG410905X membrane-flanked domain protein WR51_05640 ENOG4105CKV Membrane WR51_05690 ENOG410905X membrane-flanked domain protein WR51_05695 ENOG4105CKV Membrane WR51_05700 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation WR51_05705 ENOG4105BZ4 penicillin-binding protein WR51_05715 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) WR51_05720 ENOG4105C1Q protoporphyrinogen oxidase WR51_05745 ENOG4105NA0 Transcriptional regulator WR51_05760 ENOG4105ECB domain protein WR51_05780 ENOG4108MK9 spermidine N(1)-acetyltransferase WR51_05790 ENOG4106AXD WR51_05795 ENOG4108RQ5 Beta-lactamase domain-containing protein WR51_05800 ENOG4105DF9 Lipoate-protein, ligase WR51_05810 ENOG4105CEY Amp-dependent synthetase and ligase WR51_05820 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein WR51_05825 ENOG4108I5D sulfate abc transporter WR51_05830 ENOG4105ECW sulfate abc transporter WR51_05835 ENOG4108IJ6 ABC transporter WR51_05840 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) WR51_05850 ENOG4107RN3 metallophosphoesterase WR51_05855 ENOG4107TVP HD domain protein WR51_05865 ENOG4108AEY RNA polymerase sigma factor WR51_05870 ENOG41086D8 Transcriptional regulator WR51_05885 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR51_05905 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 WR51_05910 ENOG4105C8Q Methyl-accepting chemotaxis WR51_05915 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) WR51_05925 ENOG4107QP3 malate synthase g WR51_05945 ENOG4105VEQ Cold shock protein WR51_05980 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation WR51_05985 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WR51_06025 ENOG4105ERH Fumarylacetoacetate hydrolase WR51_06035 ENOG4105C8Y Acetylornithine aminotransferase WR51_06050 ENOG4105CAQ asparagine synthetase WR51_06055 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) WR51_06060 ENOG4105CH6 catalase WR51_06065 ENOG4105BZU Histidine kinase WR51_06085 ENOG4105QNR S1 RNA binding domain protein WR51_06090 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WR51_06100 ENOG4107AYK membrAne WR51_06105 ENOG41073B9 WR51_06115 ENOG4108KP7 hydrolase WR51_06130 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit WR51_06155 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) WR51_06160 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) WR51_06175 ENOG4105C31 Tryptophanyl-tRNA synthetase WR51_06190 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WR51_06195 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WR51_06205 ENOG4108JQ7 (ABC) transporter WR51_06210 ENOG4105UQX Mate efflux family protein WR51_06235 ENOG4108ZCF integral membrane protein WR51_06245 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WR51_06255 ENOG4105DPN Oligoendopeptidase f WR51_06270 ENOG4108Z18 K06886 hemoglobin WR51_06275 ENOG4105MIX Adenylate cyclase WR51_06280 ENOG4106EFP UPF0738 protein WR51_06290 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) WR51_06295 ENOG4105EMS pseudouridine synthase WR51_06315 ENOG4105K64 Glycosyl transferase, family 2 WR51_06335 ENOG4107TVC Glycosyl transferase, family 2 WR51_06355 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) WR51_06360 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase WR51_06370 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase WR51_06420 ENOG4108ZMI UPF0477 protein WR51_06455 ENOG4105CK7 Sodium proline symporter WR51_06465 ENOG4105CRQ synthase (Component I) WR51_06470 ENOG4105DDQ anthranilate synthase WR51_06480 ENOG4105DK0 Indole-3-glycerol phosphate synthase WR51_06485 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase WR51_06490 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) WR51_06575 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WR51_06595 ENOG4105C7S Dehydrogenase WR51_06600 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 WR51_06605 ENOG4105VZ8 Transcriptional regulator WR51_06670 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) WR51_06680 ENOG4105DZ1 carboxypeptidase WR51_06685 ENOG4105VFR signal peptidase WR51_06720 ENOG4105C26 Dehydrogenase WR51_06725 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WR51_06730 ENOG4105F38 ABC transporter, permease WR51_06735 ENOG4105D38 putrescine abc transporter WR51_06740 ENOG4107RUE extracellular solute-binding protein family 1 WR51_06750 ENOG4105EYF MMPL domain protein WR51_06760 ENOG4108YBP pseudouridine synthase WR51_06770 ENOG4105K4I Scp-like extracellular WR51_06775 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) WR51_06780 ENOG4105CQB FAD linked oxidase domain protein WR51_06795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR51_06800 ENOG4105BZU Histidine kinase WR51_06805 ENOG4105JXH GntR family transcriptional regulator WR51_06825 ENOG4106A3R peptidase WR51_06835 ENOG4108QTI )-transporter WR51_06840 ENOG4107TS3 membrane protein, TerC WR51_06845 ENOG4105CZN Potassium uptake protein WR51_06850 ENOG410681C small acid-soluble spore protein WR51_06855 ENOG4108Z7G MaoC domain protein dehydratase WR51_06875 ENOG4105CHR reductase WR51_06905 ENOG4105C4Y ABC transporter WR51_06910 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WR51_06915 ENOG4107RCV ABC transporter, permease WR51_06935 ENOG4105E98 transcriptional regulator DeoR family WR51_06950 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) WR51_06960 ENOG4105PXI polysaccharide deacetylase WR51_06970 ENOG4105BZU Histidine kinase WR51_06975 ENOG41090MY MarR family Transcriptional regulator WR51_06985 ENOG4106DF1 WR51_06995 ENOG4105BZU Histidine kinase WR51_07000 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) WR51_07005 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase WR51_07010 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) WR51_07060 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) WR51_07065 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WR51_07070 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WR51_07075 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family WR51_07080 ENOG4105CZV ABC transporter WR51_07090 ENOG4105CJ1 ABC, transporter WR51_07130 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A WR51_07135 ENOG4105EA8 2-Nitropropane dioxygenase WR51_07140 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD WR51_07150 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein WR51_07175 ENOG4105NQC Flavodoxin WR51_07215 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) WR51_07245 ENOG4105CZN Potassium uptake protein WR51_07250 ENOG41063Y9 WR51_07255 ENOG4105KBJ sporulation protein ytfj WR51_07285 ENOG4105CM2 brancheD-chain amino acid aminotransferase WR51_07290 ENOG4105C7K acetolactate synthase WR51_07295 ENOG4108ZP8 Acetolactate synthase small subunit WR51_07300 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase WR51_07315 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WR51_07335 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) WR51_07340 ENOG4105ECC imidazole-glycerol-phosphate dehydratase WR51_07345 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) WR51_07370 ENOG4107RVV histidinol phosphate phosphatase, hisj family WR51_07385 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase WR51_07390 ENOG4105E0M Sulfatase WR51_07400 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) WR51_07420 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) WR51_07425 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) WR51_07435 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WR51_07440 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein WR51_07445 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein WR51_07455 ENOG4105C8J )-transporter WR51_07475 ENOG4105DFD Na H antiporter WR51_07495 ENOG4105ENE Histidine kinase WR51_07500 ENOG4105WH1 Two component transcriptional regulator luxr family WR51_07520 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WR51_07545 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) WR51_07570 ENOG4105CJ3 phosphate transporter WR51_07575 ENOG4107GRR phosphate transport regulator WR51_07580 ENOG4105BZ4 penicillin-binding protein WR51_07595 ENOG4105BZU Histidine kinase WR51_07600 ENOG4105I3N Conserved Protein WR51_07615 ENOG4105BZU Histidine kinase WR51_07645 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WR51_07650 ENOG4105DZ1 carboxypeptidase WR51_07655 ENOG4108JIC nucleoside recognition domain protein WR51_07665 ENOG4105FE9 pseudouridine synthase WR51_07670 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WR51_07675 ENOG4107TWT Cytochrome c biogenesis protein WR51_07680 ENOG4105CRE cytochrome C WR51_07685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR51_07690 ENOG4105BZU Histidine kinase WR51_07695 ENOG4108WBT adenosyltransferase WR51_07710 ENOG4108SAX Membrane WR51_07725 ENOG4105C9U ATP-dependent DNA helicase RecQ WR51_07730 ENOG4105I7S Abortive infection protein WR51_07740 ENOG4107RGJ metallophosphoesterase WR51_07745 ENOG4108XDN Transcriptional regulator WR51_07750 ENOG4108S6Z Negative regulator of genetic competence WR51_07775 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase WR51_07780 ENOG4107RB3 L-asparaginase WR51_07815 ENOG4105S2F WR51_07820 ENOG41065D1 WR51_07850 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) WR51_07865 ENOG4105XXQ heptaprenyl diphosphate synthase component I WR51_07875 ENOG4105EAH synthase WR51_07880 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) WR51_07885 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase WR51_07900 ENOG41068YB TPR repeat-containing protein WR51_07915 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) WR51_07920 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) WR51_07955 ENOG4108JYZ YitT family WR51_07960 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase WR51_07975 ENOG4105FJR Lmbe family WR51_07980 ENOG4105CPK Glycosyl transferase (Group 1 WR51_08005 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) WR51_08020 ENOG4105DVT helicase WR51_08025 ENOG4105YAC WR51_08045 ENOG4105CSM endonuclease III WR51_08055 ENOG4105BZ4 penicillin-binding protein WR51_08095 ENOG4106F55 Protein of unknown function (DUF1273) WR51_08105 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) WR51_08115 ENOG4105DVT helicase WR51_08120 ENOG4105CTD carboxy-peptidase WR51_08130 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) WR51_08140 ENOG4105C2W permease WR51_08150 ENOG410890F Dynamin family WR51_08160 ENOG4108W0I acetyltransferase WR51_08170 ENOG4105KHC sulfurtransferase WR51_08215 ENOG4105HTX biosynthesis protein WR51_08245 ENOG4105CPK Glycosyl transferase (Group 1 WR51_08280 ENOG41081VK Ribonuclease WR51_08345 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WR51_08355 ENOG4107RWR Sodium hydrogen exchanger WR51_08360 ENOG4108Z5V transcriptional regulator, merr family WR51_08370 ENOG4105H67 Protein of unknown function (DUF421) WR51_08375 ENOG41080C8 DUF218 domain WR51_08385 ENOG4105DQ6 Transposase WR51_08445 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) WR51_08455 ENOG4107R0U MotA TolQ exbB proton channel WR51_08460 ENOG4105ER2 Ompa motb domain protein WR51_08465 ENOG4107YTP response regulator receiver protein WR51_08470 ENOG4105CBS Chea signal transduction histidine kinase WR51_08475 ENOG4105DD5 Flagellar motor switch protein WR51_08490 ENOG4105BZU Histidine kinase WR51_08510 ENOG4105E1Q flagellar hook-associated protein WR51_08515 ENOG4105DTJ flagellar hook-associated protein WR51_08535 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) WR51_08540 ENOG4108ZC9 flagellar basal-body rod protein flgc WR51_08545 ENOG41075Z6 flagellar hook-basal body complex protein fliE WR51_08550 ENOG4107U2N Flagellar M-ring protein WR51_08555 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WR51_08585 ENOG4105BZE flagellar hook protein, FlgE WR51_08600 ENOG4107R88 Chemotaxis protein (CheV) WR51_08615 ENOG4105I03 Flagellin WR51_08620 ENOG4105E4C Lytic transglycosylase catalytic WR51_08630 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WR51_08635 ENOG4105DD5 Flagellar motor switch protein WR51_08645 ENOG4105CN7 Flagellar biosynthetic protein FliP WR51_08650 ENOG4105VS8 Flagellar biosynthetic protein fliq WR51_08660 ENOG4105D00 flagellar biosynthetic protein flhB WR51_08665 ENOG4105D7B Flagellar biosynthesis protein flha WR51_08670 ENOG4105FZW flagellar biosynthesis regulator FlhF WR51_08675 ENOG4105KTQ flagellar basal-body rod protein WR51_08680 ENOG4105CPU Monooxygenase WR51_08685 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WR51_08720 ENOG4105KAC Antibiotic biosynthesis monooxygenase WR51_08745 ENOG4105DUM transcriptional regulator, lysR family WR51_08750 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WR51_08760 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component WR51_08790 ENOG4105CVJ phosphoglycerate mutase WR51_08800 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) WR51_08820 ENOG4105CAQ asparagine synthetase WR51_08840 ENOG4105PGM cation diffusion facilitator family transporter WR51_08850 ENOG4105DRR Transcriptional regulator, GntR family WR51_08855 ENOG4108UZ3 Transporter WR51_08865 ENOG4105CKI cobalamin synthesis protein WR51_08870 ENOG4108PJD permease WR51_08885 ENOG4105DFD Na H antiporter WR51_08890 ENOG4105VUF Transcriptional regulator WR51_08900 ENOG4105C9Q fumarate hydratase class II WR51_08925 ENOG4107QJQ Mate efflux family protein WR51_08930 ENOG4105EC3 peptidase S51, dipeptidase E WR51_08950 ENOG4107QIV Cytochrome c biogenesis protein WR51_08955 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WR51_08965 ENOG4107JM4 Tetratricopeptide repeat WR51_08980 ENOG4105BZC d-serine deaminase WR51_08985 ENOG4106BRA Membrane WR51_09020 ENOG4105CJ1 ABC, transporter WR51_09040 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) WR51_09050 ENOG4108IJ0 Aspartate ammonia-lyase WR51_09055 ENOG4105C6K Malic enzyme WR51_09120 ENOG4105FVX WR51_09125 ENOG4105E09 nadh pyrophosphatase WR51_09145 ENOG4105CSR polyphosphate kinase 2 WR51_09150 ENOG4105U3E Transcriptional regulator WR51_09160 ENOG4105DXI Major Facilitator superfamily WR51_09175 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) WR51_09180 ENOG4105EU0 Major facilitator Superfamily WR51_09185 ENOG4105C6T cysteine synthase WR51_09205 ENOG4105C8J )-transporter WR51_09215 ENOG4105X5K response regulator receiver protein WR51_09220 ENOG4105H67 Protein of unknown function (DUF421) WR51_09240 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) WR51_09245 ENOG4105CHR reductase WR51_09250 ENOG4105CM2 brancheD-chain amino acid aminotransferase WR51_09255 ENOG4105C7K acetolactate synthase WR51_09265 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase WR51_09270 ENOG4105C01 Dihydroxy-acid dehydratase WR51_09275 ENOG4105C7B Threonine dehydratase WR51_09300 ENOG4105C6X Major Facilitator WR51_09305 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b WR51_09315 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) WR51_09320 ENOG4105DY9 regulatoR WR51_09325 ENOG4105CYC Transferase WR51_09330 ENOG4105K5X acetyltransferase WR51_09390 ENOG41068WN WR51_09410 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) WR51_09425 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) WR51_09435 ENOG4105C0X amino acid WR51_09445 ENOG4106PZP Bacillus haemolytic enterotoxin (HBL) WR51_09480 ENOG410849A acetyltransferase, (GNAT) family WR51_09485 ENOG4105K8R UPF0145 protein WR51_09500 ENOG4107RHR regulatoR WR51_09510 ENOG4105D9N nucleoside WR51_09515 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) WR51_09545 ENOG410811B TRANSCRIPTIONal WR51_09560 ENOG4107RAQ aminopeptidase WR51_09570 ENOG4107R16 Multicopper oxidase WR51_09610 ENOG4108T5E Copper resistance protein WR51_09615 ENOG4105KTB nuclear export factor GLE1 WR51_09620 ENOG4107RT3 EamA-like transporter family WR51_09625 ENOG4105GZI Transcriptional regulator WR51_09630 ENOG4108Z40 Transcriptional regulator WR51_09635 ENOG4107ZXU DSBA oxidoreductase WR51_09640 ENOG4108TVJ Nitroreductase WR51_09650 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) WR51_09655 ENOG4106F5Q Membrane WR51_09660 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) WR51_09670 ENOG4105CKI cobalamin synthesis protein WR51_09680 ENOG4105C0Z ABC transporter WR51_09685 ENOG4108IV0 ABC, transporter WR51_09690 ENOG4105C32 Amino acid ABC transporter (Permease) WR51_09700 ENOG4105SKE transcriptional Regulator LysR family WR51_09710 ENOG4105MDS 4-oxalocrotonate tautomerase WR51_09730 ENOG4105C4M (Ubiquinol oxidase) subunit I WR51_09735 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii WR51_09740 ENOG4108JJ9 ABC, transporter WR51_09745 ENOG4108JJ8 (ABC) transporter WR51_09755 ENOG4105K64 Glycosyl transferase, family 2 WR51_09765 ENOG4108UT6 Transferase hexapeptide repeat containing protein WR51_09820 ENOG4105BZ1 (ABC) transporter WR51_09825 ENOG4105EFI regulatoR WR51_09830 ENOG4105BZU Histidine kinase WR51_09850 ENOG41075D4 Aminoglycoside 6-adenylyltransferase WR51_09855 ENOG4108ZJ4 polysaccharide deacetylase WR51_09875 ENOG4105D6E homoserine dehydrogenase WR51_09885 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) WR51_09900 ENOG4108KGH TRANSCRIPTIONal WR51_09910 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR51_09915 ENOG4105BZU Histidine kinase WR51_09920 ENOG4107VMI polysaccharide deacetylase WR51_09930 ENOG4105KT7 mgtC SapB transporter WR51_09935 ENOG4105VRR gCN5-related N-acetyltransferase WR51_09945 ENOG4105DUU IucA IucC family protein WR51_09950 ENOG4105CEY Amp-dependent synthetase and ligase WR51_09965 ENOG4108WBH protein TIM barrel WR51_09970 ENOG4105YWU small acid-soluble spore protein WR51_09980 ENOG4108ZUB Lysine exporter protein (Lyse ygga) WR51_09985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR51_10035 ENOG4105KRN Transcriptional regulator, abrb family WR51_10045 ENOG4105YVS arsR family transcriptional regulator WR51_10050 ENOG4105CPC Aldo Keto reductase WR51_10080 ENOG4105C8Q Methyl-accepting chemotaxis WR51_10100 ENOG4108K88 Membrane WR51_10105 ENOG4108WPJ Ferritin-like domain WR51_10120 ENOG4105DEN Luciferase family WR51_10135 ENOG4105VMI -acetyltransferase WR51_10140 ENOG4107QM2 Aldo Keto reductase WR51_10145 ENOG4105CKI cobalamin synthesis protein WR51_10155 ENOG4105DSE periplasmic solute binding protein WR51_10165 ENOG4105K4T epimerase WR51_10175 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) WR51_10220 ENOG4107T5V SNARE associated Golgi WR51_10235 ENOG4108PJD permease WR51_10245 ENOG4108S4H thioesterase Superfamily protein WR51_10250 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WR51_10270 ENOG4105SXS Protein of unknown function (DUF456) WR51_10275 ENOG4105C37 (CBS) domain WR51_10295 ENOG4108Z7R Chaperone CsaA WR51_10315 ENOG4108ZRV stage ii sporulation protein p WR51_10325 ENOG4108VXD carboxy-peptidase WR51_10345 ENOG4105DQ6 Transposase WR51_10365 ENOG4108ZRV stage ii sporulation protein p WR51_10375 ENOG4108X4Q Hydrolase WR51_10380 ENOG41082F9 transcriptional regulator WR51_10385 ENOG4105D94 Major Facilitator Superfamily WR51_10395 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) WR51_10400 ENOG4107RBS Methyltransferase WR51_10415 ENOG41087PP glycosyltransferase MGT family WR51_10420 ENOG4108JYZ YitT family WR51_10425 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR51_10455 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) WR51_10505 ENOG4105KBJ sporulation protein ytfj WR51_10530 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WR51_10550 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) WR51_10555 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily WR51_10565 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein WR51_10570 ENOG4105EMN RNA polymerase sigma factor WR51_10585 ENOG4105CNW domain protein WR51_10595 ENOG4108V06 Glutathione peroxidase WR51_10610 ENOG4105C7R Atpase associated with various cellular activities aaa_3 WR51_10620 ENOG4108IUE nitrate reductase beta subunit WR51_10625 ENOG4105R3A Nitrate reductase WR51_10635 ENOG4107V6Q Cyclic nucleotide-binding domain WR51_10640 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WR51_10645 ENOG4105D06 uba thif-type nad fad binding protein WR51_10650 ENOG4105CVM Molybdenum cofactor synthesis domain protein WR51_10655 ENOG4108ZAF Molybdopterin WR51_10685 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein WR51_10690 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein WR51_10695 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WR51_10700 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit WR51_10705 ENOG4108IFG nitrite reductase, (NAD(P)H) WR51_10710 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) WR51_10745 ENOG4105MCT stage V sporulation protein S WR51_10770 ENOG4105C5H ABC transporter WR51_10785 ENOG4108UUM single-stranded DNA-binding protein WR51_10815 ENOG4107YX5 Pfam:DUF548 WR51_10820 ENOG4105C75 arginyL-tRNA synthetase WR51_10835 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) WR51_10860 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) WR51_10865 ENOG4105C5S asparaginyl-tRNA synthetase WR51_10885 ENOG4105EC2 ftsk spoIIIe WR51_10990 ENOG4105C8J )-transporter WR51_11010 ENOG4107XGZ Hydrolase WR51_11015 ENOG4105CY2 Citrate transporter WR51_11035 ENOG4105KD7 acetyltransferase WR51_11045 ENOG4105VMP Transcriptional regulator WR51_11050 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase WR51_11075 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 WR51_11090 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) WR51_11105 ENOG4107RVG penicillin-binding protein WR51_11115 ENOG4105E9Q Acyl-transferase WR51_11120 ENOG4108UT2 hemolysin iii WR51_11130 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) WR51_11140 ENOG4108RCR degv family WR51_11150 ENOG4108KF3 Electron transport protein SCO1 SenC WR51_11155 ENOG4107Y70 Heat shock protein WR51_11160 ENOG4105CAQ asparagine synthetase WR51_11175 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase WR51_11180 ENOG4108MES Periplasmic binding protein WR51_11185 ENOG4105F0I Aminotransferase WR51_11215 ENOG4105D8X mechanosensitive ion channel WR51_11220 ENOG4105BZU Histidine kinase WR51_11225 ENOG4105WH1 Two component transcriptional regulator luxr family WR51_11230 ENOG4106KNT transcriptional regulator WR51_11235 ENOG4107ZY0 Phenazine biosynthesis-like protein WR51_11255 ENOG4105CMG Carbohydrate kinase WR51_11260 ENOG4105C6Z Gluconate WR51_11270 ENOG4108YV3 Protein of unknown function (DUF2711) WR51_11300 ENOG4108IJ8 ABC transporter WR51_11305 ENOG4105E90 ABC transporter WR51_11340 ENOG4105C37 (CBS) domain WR51_11365 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WR51_11380 ENOG4107S4Y M20 DapE family protein YgeY WR51_11385 ENOG4108TSC N-acetyltransferase WR51_11390 ENOG4108JUB Transcriptional regulator WR51_11395 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein WR51_11440 ENOG410841Q phosphoesterase PA-phosphatase related protein WR51_11450 ENOG4105SZ6 Thioredoxin WR51_11515 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WR51_11570 ENOG4105BZ4 penicillin-binding protein WR51_11580 ENOG4105CZM Major Facilitator WR51_11585 ENOG4105W8X HesB YadR YfhF-family protein WR51_11595 ENOG4105DXD 2-methylcitrate dehydratase WR51_11600 ENOG4105CR4 methylisocitrate lyase WR51_11605 ENOG4105C1G acyl-Coa dehydrogenase WR51_11610 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WR51_11620 ENOG4105N14 lysine exporter protein LysE YggA WR51_11625 ENOG4105E39 Enoyl-CoA hydratase WR51_11640 ENOG4107RFY SbcCD D subunit WR51_11645 ENOG4105EYH Exonuclease WR51_11670 ENOG4105FCD Major Facilitator WR51_11675 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase WR51_11680 ENOG4105E4F Isochorismate synthase WR51_11685 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase WR51_11690 ENOG4105WQI isochorismatase WR51_11695 ENOG4105CEY Amp-dependent synthetase and ligase WR51_11700 ENOG4105WQT MbtH domain protein WR51_11705 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR51_11720 ENOG4105K70 DNA-binding protein WR51_11740 ENOG4105BZG amino acid carrier protein WR51_11760 ENOG4105FE9 pseudouridine synthase WR51_11765 ENOG4105C22 threonyL-tRNA synthetase WR51_11770 ENOG4105C19 ABC transporter WR51_11810 ENOG41081I9 integral membrane protein WR51_11820 ENOG4108Y4K DNA-binding transcriptional activator WR51_11835 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) WR51_11845 ENOG4105EYF MMPL domain protein WR51_11860 ENOG4105DQ6 Transposase WR51_11880 ENOG4105WCN acetyltransferase WR51_11905 ENOG4105C1Q protoporphyrinogen oxidase WR51_11915 ENOG41068WN WR51_11945 ENOG4107V2S Transcriptional regulator WR51_11950 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) WR51_11970 ENOG4105DND Transcriptional regulator WR51_11975 ENOG4108RPX mosc domain containing protein WR51_11990 ENOG4105BZ1 (ABC) transporter WR51_11995 ENOG4105BZ1 (ABC) transporter WR51_12015 ENOG4105VTR Integrase WR51_12075 ENOG4105KRN Transcriptional regulator, abrb family WR51_12155 ENOG4105CAR Terminase, large subunit WR51_12165 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) WR51_12235 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR51_12265 ENOG4108JCI Transcriptional regulator WR51_12300 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) WR51_12305 ENOG4108KPJ rna polymerase sigma factor WR51_12330 ENOG4105F32 YngK protein WR51_12350 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) WR51_12355 ENOG4105RD7 BadF BadG BcrA BcrD WR51_12360 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) WR51_12365 ENOG4107STF Involved in phosphonate degradation (By similarity) WR51_12370 ENOG4105C7B Threonine dehydratase WR51_12375 ENOG4108INS Transcriptional regulator WR51_12390 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) WR51_12400 ENOG4105C1J atp-dependent rna helicase WR51_12410 ENOG4108RZE Tetr family transcriptional regulator WR51_12500 ENOG41088CC tellurite resistance protein tehB WR51_12510 ENOG4108I0C methyltransferase WR51_12515 ENOG4107RA9 decarboxylase WR51_12520 ENOG4105K56 Transcriptional regulator WR51_12525 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) WR51_12570 ENOG4105CIN aminoacyl-histidine dipeptidase WR51_12600 ENOG4105KRN Transcriptional regulator, abrb family WR51_12610 ENOG4105EJ9 Membrane WR51_12615 ENOG4105EQK -acetyltransferase WR51_12655 ENOG4105W8Z 4'-phosphopantetheinyl transferase WR51_12675 ENOG4105CSV Glutaminase WR51_12695 ENOG4108Q8B Spore germination protein WR51_12700 ENOG4108NHD germination protein WR51_12705 ENOG4105II7 pyrroline-5-carboxylate reductase WR51_12710 ENOG4105CUB amino acid WR51_12715 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) WR51_12720 ENOG4105YWU small acid-soluble spore protein WR51_12725 ENOG41075H3 AraC family transcriptional regulator WR51_12750 ENOG4105BZU Histidine kinase WR51_12765 ENOG4108B31 Spore germination protein WR51_12815 ENOG4108IMY Transcriptional regulator WR51_12830 ENOG4107VMI polysaccharide deacetylase WR51_12835 ENOG4108RZE Tetr family transcriptional regulator WR51_12840 ENOG4105CAQ asparagine synthetase WR51_12845 ENOG4108XG2 Histidine kinase WR51_12855 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin WR51_12900 ENOG4107RVG penicillin-binding protein WR51_12915 ENOG4107RF6 penicillin-binding protein WR51_12920 ENOG4107RF6 penicillin-binding protein WR51_12930 ENOG4105DIN metallophosphoesterase WR51_12940 ENOG4105CJ1 ABC, transporter WR51_12950 ENOG4107Z3H Transcriptional regulator, TetR family WR51_12965 ENOG4105C1G acyl-Coa dehydrogenase WR51_12970 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase WR51_12975 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit WR51_12980 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase WR51_12985 ENOG4105E39 Enoyl-CoA hydratase WR51_12990 ENOG4107QX3 carboxylase WR51_12995 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WR51_13025 ENOG4105DZ1 carboxypeptidase WR51_13040 ENOG4105T9C HD domain WR51_13050 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) WR51_13070 ENOG41075H3 AraC family transcriptional regulator WR51_13100 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) WR51_13110 ENOG4107Y80 Major Facilitator superfamily WR51_13115 ENOG41061TZ Short-chain dehydrogenase reductase Sdr WR51_13120 ENOG4105KVH Transcriptional regulator WR51_13175 ENOG4105EFA 4-hydroxyphenylacetate WR51_13190 ENOG4105CPQ Dehydrogenase WR51_13200 ENOG410900G Protein of unknown function (DUF421) WR51_13205 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) WR51_13210 ENOG4108V4B ThiJ pfpI WR51_13220 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein WR51_13230 ENOG4105DK7 lysyl-tRNA synthetase WR51_13300 ENOG4105D6E homoserine dehydrogenase WR51_13310 ENOG4105CPF Cell wall formation (By similarity) WR51_13315 ENOG4105ETU transcriptional activator (TenA WR51_13340 ENOG4105VTR Integrase WR51_13365 ENOG4108IMY Transcriptional regulator WR51_13415 ENOG4105KRN Transcriptional regulator, abrb family WR51_13540 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) WR51_13605 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis WR51_13695 ENOG410667J hydrolase WR51_13700 ENOG4105BZU Histidine kinase WR51_13705 ENOG4107RF6 penicillin-binding protein WR51_13730 ENOG4108JJB ABC transporter WR51_13740 ENOG4108HGU Histidine kinase WR51_13800 ENOG4105CB2 alcohol dehydrogenase WR51_13805 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase WR51_13810 ENOG4105CJN penicillin-binding protein WR51_13820 ENOG4105FQP Beta-lactamase WR51_13865 ENOG4107Y80 Major Facilitator superfamily WR51_13880 ENOG4107VXM glycerophosphoryl diester phosphodiesterase WR51_13905 ENOG4107Y9U Membrane WR51_13950 ENOG4105FCD Major Facilitator WR51_13960 ENOG4105E09 nadh pyrophosphatase WR51_13965 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) WR51_14000 ENOG4108XI2 Domain of unknown function (DUF1963) WR51_14025 ENOG4108NRW Phospholipase, patatin family WR51_14030 ENOG4105KWG Pfam:DUF1696 WR51_14065 ENOG4105PKS Excinuclease abc c subunit domain protein WR51_14105 ENOG4107VFR oxidoreductase WR51_14130 ENOG4105U0R haloacid dehalogenase-like hydrolase WR51_14135 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR51_14140 ENOG4105BZU Histidine kinase WR51_14175 ENOG4107WD8 ABC transporter, permease WR51_14190 ENOG4105DY8 decarboxylase WR51_14205 ENOG4108IUM Glycogen debranching enzyme WR51_14215 ENOG4105CGH 5'-nucleotidase WR51_14230 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) WR51_14240 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) WR51_14245 ENOG4105FDR Membrane WR51_14255 ENOG4105CIS alcohol dehydrogenase WR51_14260 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) WR51_14305 ENOG4105MSI germination protein ypeb WR51_14335 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) WR51_14340 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) WR51_14345 ENOG4107Z3H Transcriptional regulator, TetR family WR51_14375 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family WR51_14395 ENOG4105E98 transcriptional regulator DeoR family WR51_14410 ENOG41062ES Transcriptional regulator WR51_14430 ENOG4107QKR Dehydrogenase WR51_14440 ENOG4107RUY (E1 component), alpha subunit WR51_14450 ENOG4105E1F short-chain dehydrogenase reductase WR51_14455 ENOG4105RHY Pfam:UPF0157 WR51_14495 ENOG4107SQ8 Glycine betaine WR51_14500 ENOG4108IJ7 Glycine betaine WR51_14525 ENOG4105E66 phosphoriboisomerase A WR51_14530 ENOG41082BV acetyltransferase WR51_14535 ENOG4108M1A Chitin-binding protein WR51_14565 ENOG4105MSB protein, conserved in bacteria WR51_14585 ENOG4108Z7F N-acetyltransferase WR51_14610 ENOG4105KEG ribosomal-protein-alanine acetyltransferase WR51_14615 ENOG4105EEM helicase WR51_14630 ENOG4105C9U ATP-dependent DNA helicase RecQ WR51_14655 ENOG4105DQ6 Transposase WR51_14690 ENOG4108M1A Chitin-binding protein WR51_14710 ENOG4105BZG amino acid carrier protein WR51_14715 ENOG4105C26 Dehydrogenase WR51_14720 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WR51_14725 ENOG4105CTU Proline racemase WR51_14730 ENOG4105CTU Proline racemase WR51_14735 ENOG41080HI glycine oxidase WR51_14745 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein WR51_14775 ENOG4107T5V SNARE associated Golgi WR51_14785 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD WR51_14800 ENOG4105DTQ mandelate racemase muconate lactonizing WR51_14815 ENOG4107SET aldo keto reductase WR51_14820 ENOG4105ECQ AraC Family Transcriptional Regulator WR51_14845 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) WR51_14850 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WR51_14855 ENOG4105BZU Histidine kinase WR51_14860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR51_14900 ENOG4105DPN Oligoendopeptidase f WR51_14905 ENOG4105EPR degv family WR51_14965 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) WR51_14970 ENOG4106K7D Major facilitator family transporter WR51_14995 ENOG4107BMA Transglycosylase associated protein WR51_15010 ENOG41089UC methyltransferase, type 11 WR51_15050 ENOG4105CHM Aminotransferase WR51_15065 ENOG4108ZMI UPF0477 protein WR51_15080 ENOG4105DVE abc transporter atp-binding protein WR51_15155 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) WR51_15160 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component WR51_15165 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein WR51_15170 ENOG4105D7T ABC transporter WR51_15205 ENOG4108AQF aminoglycoside N(3)-acetyltransferase WR51_15240 ENOG4107VC0 DNA alkylation repair enzyme WR51_15245 ENOG4105C6T cysteine synthase WR51_15250 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase WR51_15265 ENOG4107VMI polysaccharide deacetylase WR51_15270 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC WR51_15280 ENOG4106ETB IIa component WR51_15285 ENOG4108ZCF integral membrane protein WR51_15290 ENOG4105E0M Sulfatase WR51_15295 ENOG4105C5H ABC transporter WR51_15300 ENOG4105EYF MMPL domain protein WR51_15305 ENOG41082JN Transcriptional regulator WR51_15310 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) WR51_15335 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase WR51_15340 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase WR51_15385 ENOG41069ER domain protein WR51_15395 ENOG4105DNP FAD linked oxidase domain protein WR51_15420 ENOG4105D4B ABC, transporter WR51_15425 ENOG4105F5R ABC transporter WR51_15430 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane WR51_15440 ENOG4105DKT Transcriptional regulator WR51_15445 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) WR51_15455 ENOG41061GT Aldolase WR51_15465 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) WR51_15495 ENOG4105II7 pyrroline-5-carboxylate reductase WR51_15505 ENOG4107258 Transcriptional regulator WR51_15525 ENOG4105ECK Fatty Acid Desaturase WR51_15535 ENOG4107RBI VanW family WR51_15540 ENOG4105G6Z alkaline phosphatase WR51_15550 ENOG4105VMP Transcriptional regulator WR51_15575 ENOG41068WN WR51_15605 ENOG4105C7R Atpase associated with various cellular activities aaa_3 WR51_15625 ENOG4105C8Y Acetylornithine aminotransferase WR51_15665 ENOG4108TVJ Nitroreductase WR51_15670 ENOG4105FS7 Transcriptional regulator WR51_15705 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family WR51_15715 ENOG4105CMR udp-glucose 4-epimerase WR51_15730 ENOG4108DMH HTH_ARAC WR51_15735 ENOG4108XET gCN5-related N-acetyltransferase WR51_15750 ENOG4108PCN EamA-like transporter family WR51_15795 ENOG410635A Membrane WR51_15805 ENOG4108IQI permease WR51_15815 ENOG4105F1N DNA alkylation repair WR51_15850 ENOG4107RF6 penicillin-binding protein WR51_15855 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) WR51_15860 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) WR51_15875 ENOG4105E7W lamb ycsf family protein WR51_15885 ENOG4105P4J Allophanate hydrolase, subunit 1 WR51_15890 ENOG4107258 Transcriptional regulator WR51_15905 ENOG4106N3A copper homeostasis protein cutc WR51_15910 ENOG4108ZHR arsR family transcriptional regulator WR51_15920 ENOG4105FDT acyl-CoA dehydrogenase WR51_15935 ENOG4105DWD nucleoside recognition domain protein WR51_15980 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) WR51_16005 ENOG4105E2A Dehydrogenase WR51_16015 ENOG4105CN5 Metallo-Beta-Lactamase WR51_16025 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WR51_16040 ENOG4105CGH 5'-nucleotidase WR51_16050 ENOG4105CHJ isochorismatase hydrolase WR51_16075 ENOG41090MY MarR family Transcriptional regulator WR51_16115 ENOG4108606 TspO/MBR family WR51_16120 ENOG4105CVP deoxyribo-dipyrimidine photolyase WR51_16145 ENOG4108TWJ NADH dehydrogenase subunit 5 WR51_16150 ENOG4105GPN Uncharacterized conserved protein (DUF2294) WR51_16155 ENOG4107VMI polysaccharide deacetylase WR51_16160 ENOG4105KY5 gCN5-related N-acetyltransferase WR51_16165 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase WR51_16170 ENOG4105ECQ AraC Family Transcriptional Regulator WR51_16185 ENOG4105D6J arsenicaL-resistance protein WR51_16190 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase WR51_16195 ENOG41085FC arsR family transcriptional regulator WR51_16230 ENOG4108IG5 Transcriptional regulator WR51_16235 ENOG4105F27 Major Facilitator WR51_16240 ENOG4105M4P Tetr family transcriptional regulator WR51_16245 ENOG4105CHR reductase WR51_16250 ENOG4108YXU transcriptional regulator AsnC family WR51_16295 ENOG4105C44 Serine transporter WR51_16300 ENOG4105DUM transcriptional regulator, lysR family WR51_16305 ENOG4105DWP Membrane WR51_16330 ENOG4105CZV ABC transporter WR51_16335 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family WR51_16345 ENOG4105N0V mono-oxygenase ydhR WR51_16380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR51_16385 ENOG41062D9 Histidine kinase WR51_16455 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) WR51_16460 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR51_16485 ENOG4105K6H D-cysteine desulfhydrase WR51_16495 ENOG4105E0Y RtcB Protein WR51_16505 ENOG4105JQZ Methyltransferase WR51_16525 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) WR51_16545 ENOG4105BZU Histidine kinase WR51_16555 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) WR51_16565 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A WR51_16585 ENOG4108JQ1 Dehydrogenase WR51_16590 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) WR51_16605 ENOG41082W1 Cupin 2, conserved barrel domain protein WR51_16610 ENOG410874W AraC family transcriptional regulator WR51_16630 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR51_16635 ENOG4108IG5 Transcriptional regulator WR51_16660 ENOG4108VXD carboxy-peptidase WR51_16665 ENOG4105PNM synthesis protein WR51_16675 ENOG4108ISG Major Facilitator WR51_16690 ENOG4107MII Sugar-specific transcriptional regulator TrmB WR51_16695 ENOG4105CZM Major Facilitator WR51_16710 ENOG4105DA5 (ABC) transporter WR51_16715 ENOG41069JR WR51_16725 ENOG4105RXJ WR51_16730 ENOG4105KPY Small multidrug resistance protein WR51_16735 ENOG4105KBX Transcriptional regulator, TetR family WR51_16755 ENOG4105CRW Short chain fatty acid transporter WR51_16765 ENOG4105DYS nad(p)h dehydrogenase (quinone) WR51_16800 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) WR51_16825 ENOG4108K8S endonuclease I WR51_16855 ENOG4108Z66 YbaK ebsC protein WR51_16875 ENOG4105KVH Transcriptional regulator WR51_16880 ENOG4108RCM Nitroreductase WR51_16910 ENOG4108PSK reductase WR51_16985 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase WR51_16990 ENOG4105DKQ ROK family WR51_17000 ENOG4108UW5 maltose o-acetyltransferase WR51_17005 ENOG4105C31 Tryptophanyl-tRNA synthetase WR51_17015 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR51_17020 ENOG41089BK Glutamine amido-transferase WR51_17050 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) WR51_17060 ENOG4105EV4 Multidrug resistance protein mdtH WR51_17100 ENOG4105C37 (CBS) domain WR51_17115 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase WR51_17120 ENOG4105FAW cDP-glucose 4,6-dehydratase WR51_17150 ENOG4105DDN Pentapeptide repeat-containing protein WR51_17155 ENOG4105XDF Protein of unknown function (DUF1272) WR51_17160 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) WR51_17165 ENOG4105CMG Carbohydrate kinase WR51_17170 ENOG4105C6Z Gluconate WR51_17185 ENOG4105CV1 Transketolase (EC 2.2.1.1) WR51_17190 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase WR51_17195 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase WR51_17215 ENOG41090KN UPF0303 protein WR51_17230 ENOG4105C44 Serine transporter WR51_17260 ENOG4108TZY GntR Family Transcriptional Regulator WR51_17265 ENOG4105D9R oxidoreductase WR51_17305 ENOG4105JAB phenazine biosynthesis protein, phzf family WR51_17315 ENOG4105KNA -acetyltransferase WR51_17325 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein WR51_17330 ENOG4105KVH Transcriptional regulator WR51_17335 ENOG4107SCK Monooxygenase WR51_17350 ENOG4105DQ6 Transposase WR51_17360 ENOG4108ZJ4 polysaccharide deacetylase WR51_17450 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) WR51_17460 ENOG4107YXZ hydrolase, family 25 WR51_17495 ENOG4105H3G oxidoreductase WR51_17530 ENOG4105CIS alcohol dehydrogenase WR51_17565 ENOG4108TN2 lmbE family WR51_17575 ENOG4107R3E Citrate transporter WR51_17590 ENOG4108MES Periplasmic binding protein WR51_17595 ENOG4105EHG Permease protein WR51_17600 ENOG4105DQ5 transport system permease protein WR51_17605 ENOG4105NX3 Membrane WR51_17625 ENOG4105D9U N-acetyltransferase WR51_17630 ENOG4107CUJ Protein of unknown function (DUF2690) WR51_17640 ENOG4107V2S Transcriptional regulator WR51_17660 ENOG4105C98 muts2 protein WR51_17670 ENOG4105E5K Alpha-amylase WR51_17675 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase WR51_17680 ENOG4105DPN Oligoendopeptidase f WR51_17710 ENOG4108A04 Beta-lactamase WR51_17735 ENOG4107VXM glycerophosphoryl diester phosphodiesterase WR51_17780 ENOG41082BM Transcriptional regulator, arsr family WR51_17785 ENOG4105CIS alcohol dehydrogenase WR51_17790 ENOG4105CNG UPF0061 protein WR51_17795 ENOG4107JM4 Tetratricopeptide repeat WR51_17820 ENOG4105CQB FAD linked oxidase domain protein WR51_17835 ENOG4107TPS domain protein WR51_17840 ENOG4105CEP NADH dehydrogenase WR51_17855 ENOG4108QXE glycerophosphoryl diester phosphodiesterase WR51_17890 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C WR51_17895 ENOG4108M1A Chitin-binding protein WR51_17905 ENOG4105E1K spore germination protein WR51_17925 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase WR51_17935 ENOG4108IAJ Nad-dependent epimerase dehydratase WR51_17940 ENOG4105FAW cDP-glucose 4,6-dehydratase WR51_17945 ENOG4105D7V transposase WR51_18000 ENOG4105BZU Histidine kinase WR51_18005 ENOG4105C5H ABC transporter WR51_18010 ENOG41067SE Tetr family transcriptional regulator WR51_18015 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity WR51_18025 ENOG4108VXD carboxy-peptidase WR51_18030 ENOG4107DUR UPF0457 protein WR51_18050 ENOG4105BZU Histidine kinase WR51_18060 ENOG4105KT7 mgtC SapB transporter WR51_18070 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase WR51_18075 ENOG41073R8 VanW family WR51_18085 ENOG4108R1P WR51_18105 ENOG4105VEQ Cold shock protein WR51_18125 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) WR51_18145 ENOG410904N short-chain dehydrogenase reductase WR51_18155 ENOG4106IQC argininosuccinate lyase WR51_18170 ENOG4108IA2 Sodium pantothenate symporter WR51_18180 ENOG4105C26 Dehydrogenase WR51_18185 ENOG4105CHR reductase WR51_18195 ENOG4105EWU Squalene--hopene cyclase WR51_18205 ENOG4105FR1 rard protein WR51_18210 ENOG410696E Membrane WR51_18225 ENOG4105D1F ATP-binding protein WR51_18235 ENOG4108ZAF Molybdopterin WR51_18240 ENOG4105CVM Molybdenum cofactor synthesis domain protein WR51_18245 ENOG4105D06 uba thif-type nad fad binding protein WR51_18250 ENOG4105TMB Formate nitrite transporter WR51_18260 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) WR51_18265 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) WR51_18275 ENOG4108JB9 formate dehydrogenase WR51_18285 ENOG4105E1K spore germination protein WR51_18300 ENOG4105CUB amino acid WR51_18350 ENOG4105DQ6 Transposase WR51_18365 ENOG4108KGH TRANSCRIPTIONal WR51_18375 ENOG4105EMN RNA polymerase sigma factor WR51_18385 ENOG4105CIG ABC transporter WR51_18405 ENOG4105D9R oxidoreductase WR51_18415 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WR51_18425 ENOG4105K4P CoA-binding domain protein WR51_18430 ENOG4105C0H protease WR51_18435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR51_18445 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase WR51_18450 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) WR51_18455 ENOG4105W8X HesB YadR YfhF-family protein WR51_18480 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) WR51_18485 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WR51_18495 ENOG4108JJA ABC, transporter WR51_18500 ENOG4108I0Z Aconitate hydratase WR51_18530 ENOG4105E5W Transporter WR51_18540 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WR51_18560 ENOG4107F3J Amp-dependent synthetase and ligase WR51_18565 ENOG4107ZYJ bioY protein WR51_18570 ENOG4105CEY Amp-dependent synthetase and ligase WR51_18580 ENOG4105BZU Histidine kinase WR51_18595 ENOG4105C19 ABC transporter WR51_18610 ENOG4105CJ1 ABC, transporter WR51_18700 ENOG4107AYK membrAne WR51_18710 ENOG4105BZU Histidine kinase WR51_18715 ENOG4105FBA Phospholipase Carboxylesterase WR51_18720 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase WR51_18725 ENOG4105CK7 Sodium proline symporter WR51_18730 ENOG4105CBC glutamate synthase WR51_18735 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WR51_18740 ENOG4108VJ1 Transcriptional regulator (CarD family WR51_18745 ENOG4108903 Formimidoylglutamase WR51_18770 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) WR51_18805 ENOG4107QIV Cytochrome c biogenesis protein WR51_18815 ENOG4105CH2 amidohydrolase WR51_18825 ENOG4105CJ1 ABC, transporter WR51_18840 ENOG4107RSM transcriptional regulator WR51_18845 ENOG4105VAW lrga family WR51_18850 ENOG41067MG lrgb family WR51_18890 ENOG4105BZ1 (ABC) transporter WR51_18895 ENOG4105BZ1 (ABC) transporter WR51_18930 ENOG4108HW3 (ABC) transporter WR51_18935 ENOG4105CGH 5'-nucleotidase WR51_18945 ENOG4108SVB resolvase WR51_18965 ENOG4105K7K Transcriptional regulator WR51_18975 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase WR51_19015 ENOG4105C5F glutamine synthetase WR51_19020 ENOG4105KV4 Transcriptional regulator WR51_19025 ENOG4105CXI aluminum resistance protein WR51_19030 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) WR51_19035 ENOG4105EN6 Membrane WR51_19045 ENOG4106F1P AAA ATPase, central domain protein WR51_19075 ENOG41069ER domain protein WR51_19080 ENOG4105DM4 PTS System WR51_19085 ENOG4105DE4 1-phosphofructokinase WR51_19090 ENOG4105E98 transcriptional regulator DeoR family WR51_19095 ENOG4107QW4 alcohol dehydrogenase WR51_19100 ENOG4108SJC Membrane WR51_19115 ENOG4105C85 amino acid WR51_19135 ENOG4105TMB Formate nitrite transporter WR51_19140 ENOG4105K70 DNA-binding protein WR51_19150 ENOG4105C59 p-type ATPase WR51_19155 ENOG410681U heavy metal transport detoxification protein WR51_19160 ENOG4105DQ6 Transposase WR51_19170 ENOG4105VPX protein, conserved in bacteria WR51_19180 ENOG4105NIV Esterase WR51_19185 ENOG4105E0A ABC, transporter WR51_19205 ENOG4105CGK Exodeoxyribonuclease III WR51_19215 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) WR51_19220 ENOG4105D03 DNA-3-methyladenine glycosylase II WR51_19250 ENOG4105BZU Histidine kinase WR51_19290 ENOG41067MG lrgb family WR51_19310 ENOG4108S3Y transcriptional regulator WR51_19315 ENOG4105CS2 ec 3.2.1.21 WR51_19330 ENOG4105F0V Cell wall hydrolase WR51_19340 ENOG4105E0M Sulfatase WR51_19345 ENOG410890F Dynamin family WR51_19380 ENOG4105DQU oxidoreductase, subunit beta WR51_19385 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein WR51_19390 ENOG4108IGT Dipeptidase WR51_19395 ENOG4105MCT stage V sporulation protein S WR51_19400 ENOG4105D48 metallophosphoesterase WR51_19425 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase WR51_19440 ENOG4105XZV Protein of unknown function (DUF3243) WR51_19445 ENOG4108RKS Short-chain dehydrogenase reductase Sdr WR51_19465 ENOG4105UIB (ABC) transporter WR51_19470 ENOG4108JQ9 ABC transporter WR51_19475 ENOG4105DIH basic membrane WR51_19480 ENOG4105FDP GntR family transcriptional regulator WR51_19490 ENOG4105CNU cell division protein FtsK WR51_19500 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit WR51_19510 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WR51_19520 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) WR51_19525 ENOG4108S0H Dipicolinic acid synthetase, b subunit WR51_19600 ENOG4105CDU Replicative dna helicase WR51_19660 ENOG4105E35 Dipicolinate synthase subunit A WR51_19670 ENOG4105C1V Peptidase, M16 WR51_19690 ENOG4105DTN riboflavin biosynthesis protein ribF WR51_19705 ENOG4105W7A Protein of unknown function (DUF503) WR51_19715 ENOG4105VHM ribosomal protein WR51_19720 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination WR51_19725 ENOG4105CHV Transcription elongation factor NusA WR51_19735 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) WR51_19745 ENOG4105DZP Membrane-associated zinc metalloprotease WR51_19750 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) WR51_19755 ENOG4105KNE Phosphatidate cytidylyltransferase WR51_19760 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) WR51_19770 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) WR51_19800 ENOG4108HE4 integrase family WR51_19810 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) WR51_19815 ENOG4105C79 DNA protecting protein DprA WR51_19820 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha WR51_19835 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) WR51_19860 ENOG4105VB6 UPF0109 protein WR51_19880 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) WR51_19885 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) WR51_19900 ENOG4105CHR reductase WR51_19905 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase WR51_19920 ENOG4105CB5 ATP-dependent DNA helicase recG WR51_19925 ENOG4105DP4 dak2 domain fusion protein ylov WR51_19930 ENOG4108ZAA Alkaline-shock protein WR51_19945 ENOG4105FJ0 thiamine WR51_19950 ENOG4105DJV ribulose-phosphate 3-epimerase WR51_19955 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) WR51_19960 ENOG4105D9P serine threonine protein kinase WR51_19965 ENOG4108ZF3 Phosphatase WR51_19975 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B WR51_19990 ENOG4105C25 Primosomal protein n' WR51_19995 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase WR51_20015 ENOG4105DSJ YicC domain protein WR51_20025 ENOG4105F23 Fibronectin-binding protein WR51_20035 ENOG4105DC7 peptidase M24 WR51_20085 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) WR51_20120 ENOG4105C34 Pseudouridine synthase WR51_20135 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) WR51_20145 ENOG4105DBK s4 domain protein WR51_20150 ENOG41067XK integral membrane protein WR51_20160 ENOG4105DFA alanine racemase domain protein WR51_20165 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase WR51_20170 ENOG4105WR5 sporulation protein, YlmC YmxH family WR51_20180 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR51_20190 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) WR51_20195 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) WR51_20205 ENOG4105D4A Cell wall formation (By similarity) WR51_20210 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) WR51_20215 ENOG4105CNI cell division protein FtsW WR51_20230 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) WR51_20235 ENOG4105CJN penicillin-binding protein WR51_20240 ENOG4105CJN penicillin-binding protein WR51_20255 ENOG41074B2 UPF0747 protein WR51_20280 ENOG4105KNH Nucleic acid-binding protein WR51_20290 ENOG41063PX domain protein WR51_20295 ENOG4105D78 K07001 NTE family protein WR51_20300 ENOG4105H20 Sporulation integral membrane protein YlbJ WR51_20310 ENOG4106H78 methyltransferase WR51_20330 ENOG4107TB6 phosphoglycerate mutase WR51_20345 ENOG4106UY4 Inherit from COG: Scp-like extracellular WR51_20395 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) WR51_20400 ENOG4105CNI cell division protein FtsW WR51_20415 ENOG4108IAB Phoh family WR51_20435 ENOG4105QA2 WR51_20440 ENOG4105CI3 gtp-binding protein typa WR51_20450 ENOG4105ECY inositol monophosphatase WR51_20470 ENOG4105CXN decarboxylase WR51_20520 ENOG4105CPP Dehydrogenase, E1 component WR51_20535 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) WR51_20540 ENOG4108X4Q Hydrolase WR51_20550 ENOG4105CN5 Metallo-Beta-Lactamase WR51_20555 ENOG4107ZYR domain protein WR51_20590 ENOG4108XRC Protein of unknown function (DUF458) WR51_20600 ENOG4107IN1 Protein of unknown function (DUF1797) WR51_20615 ENOG4105EPM Diguanylate phosphodiesterase WR51_20620 ENOG4105K6S Short-chain dehydrogenase reductase Sdr WR51_20635 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) WR51_20645 ENOG4105UIN WR51_20685 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) WR51_20705 ENOG4108HGU Histidine kinase WR51_20715 ENOG4105CHM Aminotransferase WR51_20720 ENOG4105FKQ transcriptional regulator WR51_20725 ENOG4105EG2 ABC transporter, permease WR51_20735 ENOG4107FKK extracellular solute-binding protein family 1 WR51_20745 ENOG4105CG3 alpha amylase, catalytic region WR51_20790 ENOG4105CHU acetyl-coa acetyltransferase WR51_20825 ENOG4105K7K Transcriptional regulator WR51_20830 ENOG4105DTD Dehydrogenase WR51_20850 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase WR51_20875 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) WR51_20890 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WR51_20900 ENOG4105BZU Histidine kinase WR51_20920 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) WR51_20935 ENOG4105CID antiterminator WR51_20945 ENOG4105FDP GntR family transcriptional regulator WR51_20955 ENOG4105CE4 GlcNAc 6-P deacetylase WR51_20995 ENOG4107ZE5 PPIases accelerate the folding of proteins WR51_21000 ENOG4105PTM secreted protein WR51_21005 ENOG4105J7I hydrolase WR51_21015 ENOG4105G6R Stage v sporulation protein ae WR51_21025 ENOG4105CZ3 stage V sporulation protein ad WR51_21030 ENOG41090VF Stage v sporulation protein ac WR51_21050 ENOG4105C8J )-transporter WR51_21055 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR51_21065 ENOG41082AN stage II sporulation protein WR51_21070 ENOG4105DZ1 carboxypeptidase WR51_21075 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family WR51_21080 ENOG4105DVE abc transporter atp-binding protein WR51_21110 ENOG4105D7N magnesium and cobalt transport protein CorA WR51_21135 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WR51_21145 ENOG4105I3K Ferric uptake regulator, Fur family WR51_21150 ENOG4105MZ9 stage II sporulation protein m WR51_21170 ENOG4105CPC Aldo Keto reductase WR51_21175 ENOG4105CV8 reductase WR51_21180 ENOG4105RHY Pfam:UPF0157 WR51_21200 ENOG4107SKW Inherit from COG: Alpha beta hydrolase WR51_21210 ENOG4105ETE Transcriptional regulator (LacI family WR51_21215 ENOG4108YM7 Gcn5-related n-acetyltransferase WR51_21235 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) WR51_21240 ENOG4108R6K riboflavin synthase, subunit alpha WR51_21265 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) WR51_21270 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) WR51_21285 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WR51_21295 ENOG4105DFD Na H antiporter WR51_21300 ENOG4105CGH 5'-nucleotidase WR51_21370 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) WR51_21385 ENOG4108IXY short-chain dehydrogenase reductase WR51_21390 ENOG41069FQ Metallo-beta-lactamase superfamily WR51_21395 ENOG4105II7 pyrroline-5-carboxylate reductase WR51_21400 ENOG4105EJQ L-serine dehydratase WR51_21435 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic WR51_21455 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) WR51_21460 ENOG4105D9U N-acetyltransferase WR51_21475 ENOG4108VZI ErfK ybiS ycfS ynhG family protein WR51_21480 ENOG4108QEG Membrane WR51_21485 ENOG4105CDA abc transporter atp-binding protein WR51_21490 ENOG4105E5Q amino acid AbC transporter WR51_21495 ENOG4108HW3 (ABC) transporter WR51_21510 ENOG4105G7B Protein of unknown function (DUF2992) WR51_21520 ENOG4108QY0 Membrane WR51_21535 ENOG4105C7S Dehydrogenase WR51_21540 ENOG4105CPP Dehydrogenase, E1 component WR51_21555 ENOG4105CKM Branched-chain carboxylic acid kinase WR51_21560 ENOG4107RDP Dehydrogenase WR51_21575 ENOG4108JUB Transcriptional regulator WR51_21585 ENOG4108QXE glycerophosphoryl diester phosphodiesterase WR51_21600 ENOG4107QQR Sporulation WR51_21610 ENOG4105S1Z Stage IV sporulation protein B WR51_21615 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) WR51_21620 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) WR51_21625 ENOG4105DX0 Hemolysin A WR51_21635 ENOG4105CTB Polyprenyl synthetase WR51_21650 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) WR51_21660 ENOG4108ZSR alkaline shock protein WR51_21665 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase WR51_21690 ENOG410644B Stage III sporulation protein af WR51_21700 ENOG4105KQ4 Stage iii sporulation protein ad WR51_21705 ENOG4108CQH stage III sporulation protein AC WR51_21710 ENOG4105KR5 Stage iii sporulation protein WR51_21715 ENOG4105CD2 stage iii sporulation protein aa WR51_21740 ENOG4105DC7 peptidase M24 WR51_21745 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) WR51_21755 ENOG4105CBJ Metal-dependent enzyme WR51_21765 ENOG4107YBY Hydrolase WR51_21795 ENOG41082GG biotin lipoate A B protein ligase WR51_21800 ENOG4105WZW rhodanese family WR51_21825 ENOG41080TC multidrug resistance protein WR51_21865 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family WR51_21895 ENOG4105C0D helicase WR51_21980 ENOG4107R6U sodium dicarboxylate symporter WR51_22020 ENOG4105D7V transposase WR51_22025 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) WR51_22030 ENOG4105C3R Methionine synthase WR51_22040 ENOG4105C28 cystathionine WR51_22045 ENOG4105C28 cystathionine WR51_22065 ENOG4105C5X domain protein WR51_22075 ENOG4105DKQ ROK family WR51_22085 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase WR51_22100 ENOG4108UTW Plays a role in the regulation of phosphate uptake WR51_22105 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) WR51_22110 ENOG4105C8U phosphate abc transporter WR51_22115 ENOG4105C8U phosphate abc transporter WR51_22120 ENOG4105EXS phosphate abc transporter WR51_22125 ENOG4107RF6 penicillin-binding protein WR51_22135 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WR51_22160 ENOG4105N80 Ferric uptake regulator, Fur family WR51_22170 ENOG4105FDK ABC transporter WR51_22175 ENOG4108JYZ YitT family WR51_22180 ENOG41069ZM Protein of unknown function (DUF2624) WR51_22205 ENOG4105EGD dinuclear metal center protein, YbgI family WR51_22220 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR51_22225 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) WR51_22255 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) WR51_22260 ENOG4105KG3 cytidine deaminase WR51_22265 ENOG4107YR5 Diacylglycerol kinase WR51_22270 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) WR51_22275 ENOG4105CTJ Metal Dependent Phosphohydrolase WR51_22280 ENOG4105C9A Phoh family WR51_22290 ENOG41068P3 sporulation protein YqfC WR51_22300 ENOG4105KTH gatB Yqey WR51_22310 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) WR51_22315 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) WR51_22345 ENOG4105CSA Coproporphyrinogen iii oxidase WR51_22350 ENOG4105KVH Transcriptional regulator WR51_22375 ENOG4105TQK DNA polymerase iii, delta' subunit WR51_22385 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 WR51_22390 ENOG4108UK2 deaminase WR51_22395 ENOG4105KQC Competence protein WR51_22405 ENOG4105DXX methyltransferase WR51_22415 ENOG4108WF2 Metal Dependent Phosphohydrolase WR51_22425 ENOG410812S Rna-binding protein WR51_22435 ENOG4105CQW ribosome biogenesis GTPase YqeH WR51_22440 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase WR51_22455 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR51_22475 ENOG4108TVJ Nitroreductase WR51_22490 ENOG4105G6Z alkaline phosphatase WR51_22495 ENOG4105KEG ribosomal-protein-alanine acetyltransferase WR51_22500 ENOG4108MUZ hydrolase WR51_22540 ENOG4105MIR Phenylalanine 4-monooxygenase WR51_22550 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase WR51_22590 ENOG4105S6R Iron-hydroxamate transporter permease subunit WR51_22595 ENOG4108V5C ABC transporter WR51_22605 ENOG4108EKI Dehydrogenase WR51_22610 ENOG4105C28 cystathionine WR51_22640 ENOG4107XRG penicillin-binding protein WR51_22645 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) WR51_22655 ENOG4105CFP Peptidase U32 WR51_22660 ENOG4105XYU peptidase (U32 family) WR51_22665 ENOG4108VQJ O-methyltransferase WR51_22670 ENOG4105HHA aminodeoxychorismate lyase WR51_22690 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WR51_22700 ENOG4105C02 permease WR51_22715 ENOG41060CR WR51_22720 ENOG4105C7H Helicase, RecD TraA family WR51_22730 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) WR51_22735 ENOG4105C3J Cysteine desulfurase WR51_22745 ENOG4105D1H recombination factor protein RarA WR51_22750 ENOG4108VCI transcription factor, rsfa family WR51_22760 ENOG4105CUZ uba thif-type nad fad binding protein WR51_22770 ENOG4105CUT histidyl-tRNA synthetase WR51_22780 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) WR51_22785 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) WR51_22795 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) WR51_22800 ENOG41076HS cation diffusion facilitator family transporter WR51_22805 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WR51_22815 ENOG4105CKP Polysaccharide Biosynthesis Protein WR51_22820 ENOG4108QG2 Membrane WR51_22830 ENOG4105VIE preprotein translocase, subunit YajC WR51_22845 ENOG41061AI Protein of unknown function (DUF2905) WR51_22860 ENOG4108HUF Transporter WR51_22890 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase WR51_22910 ENOG4108RPX mosc domain containing protein WR51_22915 ENOG4105CQC Prephenate dehydratase WR51_22930 ENOG4105C19 ABC transporter WR51_22935 ENOG4105EWM Histidine kinase WR51_22945 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control WR51_22960 ENOG4105X36 (ribosomal) protein WR51_22970 ENOG4105C03 ribonuclease WR51_22985 ENOG4107QMS site-determining protein WR51_23000 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) WR51_23005 ENOG4105DFF Rod shape-determining protein mreb WR51_23025 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase WR51_23030 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) WR51_23040 ENOG41068KH stage VI sporulation protein D WR51_23050 ENOG4105D52 delta-aminolevulinic acid dehydratase WR51_23075 ENOG4105K56 Transcriptional regulator WR51_23095 ENOG4108IUQ atp-dependent protease WR51_23125 ENOG4108QCI YvbH-like oligomerisation region WR51_23145 ENOG4105M59 Phosphodiesterase, mj0936 family WR51_23160 ENOG4108XJQ germination protein WR51_23170 ENOG4108PCX Major Facilitator WR51_23180 ENOG4105KBX Transcriptional regulator, TetR family WR51_23190 ENOG4105PFC Transcriptional regulator WR51_23200 ENOG4105DZC cytosine deaminase WR51_23205 ENOG41067S9 phage shock protein C, PspC WR51_23210 ENOG4108JCI Transcriptional regulator WR51_23220 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) WR51_23225 ENOG4108Z40 Transcriptional regulator WR51_23230 ENOG4105RHA ABC transporter, permease WR51_23235 ENOG4108IUX (ABC) transporter WR51_23240 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family WR51_23245 ENOG4105ER2 Ompa motb domain protein WR51_23250 ENOG4105E14 MotA TolQ exbB proton channel WR51_23255 ENOG4108VXD carboxy-peptidase WR51_23265 ENOG4105E33 succinate dehydrogenase WR51_23275 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit WR51_23285 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) WR51_23290 ENOG4105K63 Thioredoxin WR51_23295 ENOG4105C10 Electron transfer flavoprotein WR51_23300 ENOG4105BZJ Electron transfer flavoprotein WR51_23305 ENOG41060WC Enoyl-CoA hydratase WR51_23310 ENOG4107Z3H Transcriptional regulator, TetR family WR51_23315 ENOG4105CEY Amp-dependent synthetase and ligase WR51_23325 ENOG4105J76 Periplasmic binding protein WR51_23330 ENOG4105S6R Iron-hydroxamate transporter permease subunit WR51_23380 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR51_23395 ENOG4105DR4 Methyltransferase WR51_23405 ENOG4105KFN sortase, SrtB family WR51_23410 ENOG4105E0A ABC, transporter WR51_23425 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) WR51_23435 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) WR51_23445 ENOG4105FE9 pseudouridine synthase WR51_23460 ENOG4105DCG PHP domain protein WR51_23475 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) WR51_23495 ENOG4105C5S asparaginyl-tRNA synthetase WR51_23500 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) WR51_23510 ENOG4108RWN rrna methyltransferase WR51_23540 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR51_23545 ENOG4105CW7 secretion protein, HlyD family WR51_23550 ENOG4108JGH Tetr family transcriptional regulator WR51_23555 ENOG4105CN9 Peptidase m42 family protein WR51_23575 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) WR51_23580 ENOG4105C22 threonyL-tRNA synthetase WR51_23585 ENOG4108TDW sporulation protein YtxC WR51_23610 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) WR51_23615 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase WR51_23620 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) WR51_23630 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) WR51_23635 ENOG4105C2M dna polymerase I WR51_23640 ENOG4105BZU Histidine kinase WR51_23645 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR51_23665 ENOG4108HMX isocitrate dehydrogenase (NADP) WR51_23670 ENOG4105BZN citrate synthase WR51_23685 ENOG4108REF Sporulation integral membrane protein ytvi WR51_23690 ENOG4105FS0 cytoplasmic membrane protein WR51_23715 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family WR51_23720 ENOG4105C6K Malic enzyme WR51_23725 ENOG4105C0B DNA polymerase III (alpha subunit) WR51_23730 ENOG4105VV2 WR51_23740 ENOG4105SFS phosphoesterase RecJ domain protein WR51_23770 ENOG4105DC7 peptidase M24 WR51_23805 ENOG4105Z7P Acetyltransferase (GNAT) family WR51_23810 ENOG41082W1 Cupin 2, conserved barrel domain protein WR51_23830 ENOG4107YZX Universal stress protein WR51_23870 ENOG4108JYZ YitT family WR51_23890 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) WR51_23900 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) WR51_23905 ENOG4105KBJ sporulation protein ytfj WR51_23920 ENOG4105EFZ amidohydrolase WR51_23930 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WR51_23965 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) WR51_23990 ENOG4108KB2 LysR family Transcriptional regulator WR51_24000 ENOG4105U5Y Transcriptional regulator WR51_24010 ENOG4105C28 cystathionine WR51_24040 ENOG4105EMN RNA polymerase sigma factor WR51_24050 ENOG4108UW5 maltose o-acetyltransferase WR51_24060 ENOG4105F1V Acetoin utilization protein WR51_24065 ENOG4105W87 Cbs domain WR51_24070 ENOG4105DGU Histone deacetylase WR51_24075 ENOG4106HB6 Alpha beta hydrolase WR51_24085 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR51_24090 ENOG4105BZU Histidine kinase WR51_24095 ENOG4107SNB ankyrin repeat protein YahD WR51_24100 ENOG4105EP9 oxidoreductase WR51_24125 ENOG4105ETE Transcriptional regulator (LacI family WR51_24135 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase WR51_24140 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase WR51_24160 ENOG4105C88 aminopeptidase WR51_24185 ENOG4108IPJ Membrane WR51_24220 ENOG4108VDD TRNA binding domain protein WR51_24250 ENOG4105C8F Beta-lactamase domain protein WR51_24265 ENOG4108V15 phosphotransferase enzyme family WR51_24270 ENOG4108IUM Glycogen debranching enzyme WR51_24285 ENOG4107QSE Dipeptidase WR51_24290 ENOG4105YW5 deoR family transcriptional regulator WR51_24305 ENOG4105CBX hi0933 family WR51_24340 ENOG4108VJ1 Transcriptional regulator (CarD family WR51_24345 ENOG4107EXU Short-chain dehydrogenase reductase Sdr WR51_24350 ENOG4105CSC Glucose uptake protein WR51_24365 ENOG4108ZAF Molybdopterin WR51_24370 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein WR51_24375 ENOG4105CVM Molybdenum cofactor synthesis domain protein WR51_24385 ENOG4105D06 uba thif-type nad fad binding protein WR51_24390 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WR51_24410 ENOG41085GJ domain protein WR51_24420 ENOG4105DWV Homoserine O-trans-acetylase WR51_24455 ENOG4105C8T Leucyl-tRNA synthetase WR51_24460 ENOG410605W Major Facilitator WR51_24465 ENOG4107S91 Sodium hydrogen exchanger WR51_24470 ENOG4105NCW Trka-c domain protein WR51_24485 ENOG4105C19 ABC transporter WR51_24505 ENOG4105N5T Radical SAM Protein WR51_24515 ENOG4105CIG ABC transporter WR51_24545 ENOG4105E8V Alpha Beta Hydrolase Fold protein WR51_24550 ENOG4108Z0R Transferase WR51_24555 ENOG4105YVM Phosphoesterase, PA-phosphatase related WR51_24560 ENOG4105BZF Glycosyl transferase (Group 1 WR51_24570 ENOG4105EPU Molybdenum cofactor synthesis domain protein WR51_24650 ENOG4105BZU Histidine kinase WR51_24655 ENOG4105BZU Histidine kinase WR51_24660 ENOG4105CH6 catalase WR51_24665 ENOG4107S9D Alpha beta hydrolase WR51_24670 ENOG4107T7U Sulfatase WR51_24690 ENOG4105D2X ABC transporter substrate-binding protein WR51_24700 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component WR51_24715 ENOG4107XGZ Hydrolase WR51_24765 ENOG4108V2W Carbonate dehydratase WR51_24770 ENOG4105C4M (Ubiquinol oxidase) subunit I WR51_24775 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii WR51_24810 ENOG41087YS Phage shock protein A WR51_24835 ENOG4105N67 Proton-coupled thiamine transporter YuaJ WR51_24840 ENOG4105BZU Histidine kinase WR51_24845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR51_24870 ENOG4108UGV hypoxanthine phosphoribosyltransferase WR51_24875 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) WR51_24905 ENOG4107ZTW SNARE associated Golgi WR51_24920 ENOG4105C19 ABC transporter WR51_24925 ENOG41086D8 Transcriptional regulator WR51_24940 ENOG41082BM Transcriptional regulator, arsr family WR51_24990 ENOG4105C6Z Gluconate WR51_24995 ENOG4105FDP GntR family transcriptional regulator WR51_25015 ENOG41069H0 dihydroorotase EC 3.5.2.3 WR51_25035 ENOG4105DTQ mandelate racemase muconate lactonizing WR51_25040 ENOG4105CEY Amp-dependent synthetase and ligase WR51_25045 ENOG4108IPT Naphthoate synthase WR51_25050 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) WR51_25055 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) WR51_25060 ENOG4105E4F Isochorismate synthase WR51_25065 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase WR51_25075 ENOG4105VEQ Cold shock protein WR51_25120 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) WR51_25125 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) WR51_25135 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin WR51_25270 ENOG4105KT7 mgtC SapB transporter WR51_25275 ENOG4107PBV potassium channel WR51_25295 ENOG4105WG9 Conserved Protein WR51_25305 ENOG4105CHM Aminotransferase WR51_25310 ENOG4108ZB6 transcriptional regulator AsnC family WR51_25315 ENOG4105C5I Dehydrogenase WR51_25320 ENOG4108MUZ hydrolase WR51_25330 ENOG4105C87 Aminotransferase class I and II WR51_25345 ENOG4105Y38 Kinase-associated protein B WR51_25355 ENOG4107R3E Citrate transporter WR51_25370 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) WR51_25375 ENOG4105KA0 thioesterase Superfamily protein WR51_25395 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase WR51_25420 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) WR51_25425 ENOG4106YN8 Prenyltransferase WR51_25435 ENOG41069ER domain protein WR51_25450 ENOG4105CEP NADH dehydrogenase WR51_25475 ENOG4105EWC Purine nucleoside phosphorylase WR51_25485 ENOG4108VQJ O-methyltransferase WR51_25500 ENOG4108YX9 iron--sulfur cluster insertion protein erpA WR51_25525 ENOG4108JJA ABC, transporter WR51_25530 ENOG4105C4B ABC transporter, permease WR51_25535 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA WR51_25565 ENOG41083MR nifu domain-containing protein WR51_25580 ENOG4108W5N phosphatidylglycerophosphatase a WR51_25600 ENOG4105DAX Pfam:DUF2983 WR51_25610 ENOG4105DYS nad(p)h dehydrogenase (quinone) WR51_25615 ENOG4105D4U had-superfamily hydrolase, subfamily iia WR51_25630 ENOG4105CBT Fructose-1,6-bisphosphatase WR51_25655 ENOG4105MMD transcriptional regulator WR51_25660 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) WR51_25665 ENOG4107TXC Transcriptional regulator WR51_25670 ENOG41090T1 Membrane WR51_25695 ENOG4105FAA peptidase M23 WR51_25700 ENOG4108YTE sporulation protein YunB WR51_25705 ENOG4105KZD Domain of unknown function (DUF1805) WR51_25710 ENOG4107R8B 5'-nucleotidase WR51_25715 ENOG4105DIW FeS assembly protein SUFB WR51_25720 ENOG4108UNV SUF system FeS assembly protein, NifU family WR51_25725 ENOG4105C9B Cysteine desulfurase WR51_25730 ENOG4105JRK feS assembly protein SufD WR51_25735 ENOG4105C3K feS assembly ATPase SufC WR51_25740 ENOG4105D01 (LipO)protein WR51_25745 ENOG4105D01 (LipO)protein WR51_25750 ENOG4108UMI ABC transporter, permease WR51_25755 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WR51_25780 ENOG41080E8 Transcriptional regulator, Spx MgsR family WR51_25815 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) WR51_25840 ENOG4108W8B Beta-lactamase domain protein WR51_25845 ENOG4105C1G acyl-Coa dehydrogenase WR51_25850 ENOG4105CHU acetyl-coa acetyltransferase WR51_25865 ENOG4105DZ1 carboxypeptidase WR51_25885 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer WR51_25900 ENOG4108SUT Major Facilitator Superfamily WR51_25905 ENOG4107R7I amino acid WR51_25920 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins WR51_25930 ENOG4107AYK membrAne WR51_25965 ENOG4107ZTW SNARE associated Golgi WR51_25975 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein WR51_25980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR51_25985 ENOG4105BZU Histidine kinase WR51_26015 ENOG4105C8Q Methyl-accepting chemotaxis WR51_26020 ENOG4105VG1 fes assembly suf system protein WR51_26025 ENOG4105D4Y metalloprotease WR51_26030 ENOG4105C2I pirin domain protein WR51_26045 ENOG4107T5V SNARE associated Golgi WR51_26050 ENOG4107S91 Sodium hydrogen exchanger WR51_26055 ENOG4105NCW Trka-c domain protein WR51_26070 ENOG4108RMU ferritin dps family protein WR51_26090 ENOG4108URH decarboxylase WR51_26100 ENOG41090A1 ferritin WR51_26110 ENOG4105D9N nucleoside WR51_26115 ENOG4105D9N nucleoside WR51_26130 ENOG4108RYK Nad-dependent epimerase dehydratase WR51_26145 ENOG4105CV8 reductase WR51_26150 ENOG4105F27 Major Facilitator WR51_26155 ENOG4105KVH Transcriptional regulator WR51_26170 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) WR51_26175 ENOG4105D4A Cell wall formation (By similarity) WR51_26195 ENOG4105WMR Protein CrcB homolog WR51_26200 ENOG4105WMR Protein CrcB homolog WR51_26215 ENOG4108MK9 spermidine N(1)-acetyltransferase WR51_26220 ENOG4108VY7 phosphate-starvation-inducible protein PsiE WR51_26230 ENOG4108W2Y isochorismatase WR51_26250 ENOG4108V2W Carbonate dehydratase WR51_26255 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) WR51_26275 ENOG4108IPW abc transporter atp-binding protein WR51_26280 ENOG4105CM4 permease protein WR51_26305 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) WR51_26315 ENOG4105XZU Preprotein translocase, subunit SecG WR51_26320 ENOG41067MG lrgb family WR51_26370 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR51_26380 ENOG4105RHA ABC transporter, permease WR51_26385 ENOG4108IUX (ABC) transporter WR51_26390 ENOG4105BZU Histidine kinase WR51_26395 ENOG4108W5X Transcriptional Regulator, LuxR family WR51_26450 ENOG41090VF Stage v sporulation protein ac WR51_26455 ENOG4105CZ3 stage V sporulation protein ad WR51_26470 ENOG4108QY0 Membrane WR51_26475 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) WR51_26480 ENOG4105KRI phosphocarrier protein (HPr WR51_26490 ENOG4105CHW UPF0052 protein WR51_26495 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) WR51_26500 ENOG4108Z4K mutator MutT protein WR51_26510 ENOG4105C3M thioredoxin reductase WR51_26520 ENOG4108S4C acetyltransferase WR51_26540 ENOG41086DT Membrane protein of unknown function WR51_26545 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) WR51_26565 ENOG4107TXC Transcriptional regulator WR51_26585 ENOG4105DUM transcriptional regulator, lysR family WR51_26595 ENOG4108WS4 fmn reductase WR51_26600 ENOG4105C5H ABC transporter WR51_26610 ENOG4105BZ1 (ABC) transporter WR51_26620 ENOG4105CN1 protease WR51_26625 ENOG4105CRP Part of the ABC transporter FtsEX involved in WR51_26630 ENOG4105CAK Cell division ATP-binding protein ftsE WR51_26645 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) WR51_26660 ENOG4108RDQ ABC transporter WR51_26690 ENOG4105MS2 ribosomal subunit Interface protein WR51_26695 ENOG4105VEQ Cold shock protein WR51_26700 ENOG41081UC Inherit from COG: Competence protein WR51_26715 ENOG4105KVH Transcriptional regulator WR51_26725 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein WR51_26730 ENOG4108KGH TRANSCRIPTIONal WR51_26735 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase WR51_26740 ENOG4105C6Y Udp-glucose 6-dehydrogenase WR51_26745 ENOG4105ESV Glycosyl transferase, family 4 WR51_26755 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WR51_26775 ENOG4105F8D glycoside hydrolase family 4 WR51_26780 ENOG4105VCP PTS System WR51_26785 ENOG4105CK1 PTS System WR51_26795 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) WR51_26800 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) WR51_26805 ENOG4105VCP PTS System WR51_26815 ENOG4105VZJ PTS System WR51_26835 ENOG4105ECB domain protein WR51_26840 ENOG4107RSM transcriptional regulator WR51_26875 ENOG4105DAA L-lactate WR51_26885 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) WR51_26895 ENOG4105E0M Sulfatase WR51_26920 ENOG4107R8N Glycosyl transferase, family 2 WR51_26930 ENOG4105C94 Transporter WR51_26935 ENOG41069ER domain protein WR51_26960 ENOG4105KBK Zinc finger, swim domain protein WR51_26965 ENOG4105C0D helicase WR51_26995 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR51_27005 ENOG4107RBB ABC transporter, permease WR51_27010 ENOG4105C19 ABC transporter WR51_27020 ENOG4105CXY transporter WR51_27035 ENOG4105BZU Histidine kinase WR51_27040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR51_27045 ENOG4105CMR udp-glucose 4-epimerase WR51_27050 ENOG4105CMR udp-glucose 4-epimerase WR51_27060 ENOG4108KGH TRANSCRIPTIONal WR51_27070 ENOG4105C6Y Udp-glucose 6-dehydrogenase WR51_27085 ENOG4107T8Q Glycosyl transferase (Group 1 WR51_27090 ENOG4105K64 Glycosyl transferase, family 2 WR51_27095 ENOG4108PQP glycosyl transferase group 1 WR51_27110 ENOG4105D3Q Sugar transferase WR51_27115 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase WR51_27125 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase WR51_27130 ENOG4108RB3 Capsular polysaccharide biosynthesis protein WR51_27135 ENOG4107YJ4 chain length determinant protein WR51_27140 ENOG4105HTX biosynthesis protein WR51_27145 ENOG4107YJ4 chain length determinant protein WR51_27160 ENOG4105MT0 Sporulation transcriptional regulator spoiiid WR51_27170 ENOG4105FRN stage II sporulation protein WR51_27185 ENOG4105DY9 regulatoR WR51_27205 ENOG4106778 Protein of unknown function (DUF1146) WR51_27210 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WR51_27215 ENOG4105C8S subunit m WR51_27220 ENOG4105D65 subunit l WR51_27245 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WR51_27250 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain WR51_27260 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain WR51_27265 ENOG4105BZU Histidine kinase WR51_27315 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) WR51_27320 ENOG41062M3 atp synthase WR51_27340 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) WR51_27345 ENOG4108UIC UPF0340 protein WR51_27350 ENOG4108YZG isomerase WR51_27365 ENOG4108VGI doxx family WR51_27370 ENOG4107XC4 flavin reductase domain protein, FMN-binding WR51_27390 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WR51_27400 ENOG4108ZXQ stage ii sporulation protein r WR51_27405 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) WR51_27410 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) WR51_27425 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) WR51_27430 ENOG4105CBT Fructose-1,6-bisphosphatase WR51_27435 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) WR51_27455 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) WR51_27470 ENOG4105C1G acyl-Coa dehydrogenase WR51_27475 ENOG4105C1G acyl-Coa dehydrogenase WR51_27480 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WR51_27490 ENOG4105DF6 Fe-S oxidoreductase WR51_27505 ENOG4105BZU Histidine kinase WR51_27520 ENOG4105D4Y metalloprotease WR51_27530 ENOG4105BZU Histidine kinase WR51_27535 ENOG4105KCT ABC transporter WR51_27540 ENOG4108M15 ABC transporter WR51_27545 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) WR51_27555 ENOG4105IIU Aminopeptidase WR51_27575 ENOG4105EMN RNA polymerase sigma factor WR51_27585 ENOG410684U Domain of unknown function (DUF1934) WR51_27610 ENOG4105CYW agmatinase WR51_27620 ENOG4105DXB Major Facilitator superfamily WR51_27625 ENOG4107SWG transcriptional regulator MERR family WR51_27630 ENOG4108QXE glycerophosphoryl diester phosphodiesterase WR51_27635 ENOG4105BZ4 penicillin-binding protein WR51_27640 ENOG4108XFG YwhD family WR51_27645 ENOG4108Z4T Peptidase M50 WR51_27650 ENOG41069HH 4-oxalocrotonate tautomerase WR51_27655 ENOG4105DCI Phosphohydrolase WR51_27660 ENOG4108MES Periplasmic binding protein WR51_27665 ENOG4105E0A ABC, transporter WR51_27670 ENOG4105EHG Permease protein WR51_27675 ENOG4105DQ5 transport system permease protein WR51_27685 ENOG4108VCI transcription factor, rsfa family WR51_27690 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) WR51_27695 ENOG4108IJ2 phosphate acetyltransferase WR51_27700 ENOG4107UEZ chlorite dismutase WR51_27710 ENOG4108VKI Cell wall hydrolase WR51_27730 ENOG4107SVH Potassium channel protein WR51_27740 ENOG410667J hydrolase WR51_27745 ENOG4105VCH membrane WR51_27755 ENOG4108TU7 Inherit from COG: (ABC) transporter WR51_27760 ENOG4105CJ1 ABC, transporter WR51_27765 ENOG41090WU lipolytic protein G-D-S-L family WR51_27780 ENOG4105D6E homoserine dehydrogenase WR51_27785 ENOG4105CVG Homoserine O-transsuccinylase WR51_27805 ENOG4108Y4K DNA-binding transcriptional activator WR51_27815 ENOG4105WH1 Two component transcriptional regulator luxr family WR51_27820 ENOG4105BZU Histidine kinase WR51_27825 ENOG4105DWF phosphomethylpyrimidine kinase WR51_27830 ENOG4105BZU Histidine kinase WR51_27835 ENOG4105VCD cytoplasmic protein WR51_27840 ENOG4105D22 carbon starvation protein WR51_27845 ENOG4105DY9 regulatoR WR51_27850 ENOG41079KZ Major Facilitator Superfamily WR51_27860 ENOG4105CG5 Glycosyl transferase (Group 1 WR51_27870 ENOG4105EN6 Membrane WR51_27875 ENOG4106YBV Methyl-accepting chemotaxis WR51_27885 ENOG4108S4H thioesterase Superfamily protein WR51_27890 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) WR51_27900 ENOG4105K64 Glycosyl transferase, family 2 WR51_27910 ENOG4105EJV Membrane WR51_27915 ENOG4105CKK Glycosyl transferase, family 2 WR51_27925 ENOG4108IG5 Transcriptional regulator WR51_27930 ENOG4105C5H ABC transporter WR51_27935 ENOG41067SE Tetr family transcriptional regulator WR51_27945 ENOG4105E0X reductase WR51_27950 ENOG4106F5Q Membrane WR51_27965 ENOG4108NEV two component transcriptional regulator, LytTR family WR51_27970 ENOG4108HRK Histidine kinase WR51_27975 ENOG4107RGD Major Facilitator superfamily WR51_27990 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WR51_28000 ENOG4105IW1 AmiS UreI transporter WR51_28010 ENOG4105CMR udp-glucose 4-epimerase WR51_28015 ENOG4108UT2 hemolysin iii WR51_28025 ENOG4105C1J atp-dependent rna helicase WR51_28030 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) WR51_28035 ENOG4105DPN Oligoendopeptidase f WR51_28045 ENOG4105BZU Histidine kinase WR51_28060 ENOG4105C0H protease WR51_28065 ENOG4105Q2H domain protein WR51_28080 ENOG4105BZU Histidine kinase WR51_28085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR51_28110 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis WR51_28115 ENOG4105CDU Replicative dna helicase WR51_28125 ENOG4105BZR domain protein WR51_28130 ENOG4108XMW Membrane WR51_28140 ENOG4108UUM single-stranded DNA-binding protein WR51_28150 ENOG4105C3G gtp-binding protein WR51_28155 ENOG4105VDK protein, conserved in bacteria WR51_28160 ENOG4105D8X mechanosensitive ion channel WR51_28165 ENOG4108ZDA Sporulation protein YyaC WR51_28170 ENOG4105FA0 parb-like partition protein WR51_28175 ENOG4107QJE Chromosome Partitioning Protein WR51_28190 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) WR51_28195 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) WR51_28205 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins WR51_28230 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin WR51_28285 ENOG4105CEY Amp-dependent synthetase and ligase WR51_28310 ENOG4107Y80 Major Facilitator superfamily WR51_28350 ENOG4105D7V transposase WR51_28370 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) WR51_28375 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase WR51_28380 ENOG4105C1B dTDP-glucose 4-6-dehydratase WR51_28385 ENOG4105C5E polysaccharide biosynthesis protein WR51_28435 ENOG4105D7V transposase WR51_28440 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) WR51_28450 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) WR51_28490 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) WR51_28585 ENOG4105D4Y metalloprotease WR51_28645 ENOG41067FT ParB-like nuclease domain WR51_28675 ENOG4105TRI Hydrolase WR51_28715 ENOG4105IBP Cyclic peptide transporter WR51_28720 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) WR51_28725 ENOG4105C0W non-ribosomal peptide synthetase WR51_28740 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) WR51_28745 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WR51_28760 ENOG4105C1G acyl-Coa dehydrogenase WR51_28780 ENOG4105C0W non-ribosomal peptide synthetase WR51_28780 ENOG4105C0W non-ribosomal peptide synthetase WR51_28805 ENOG4107SET aldo keto reductase WR51_28865 ENOG4105C4R Atp-dependent dna helicase WR51_28870 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) WR51_28880 ENOG4107UNZ domain protein WR51_28940 ENOG4105C4R Atp-dependent dna helicase WR51_28975 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WR51_28995 ENOG410645S MarR family Transcriptional regulator WR51_29010 ENOG4105K70 DNA-binding protein WR51_29040 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR51_29080 ENOG4105CAQ asparagine synthetase WR51_29085 ENOG4108RZE Tetr family transcriptional regulator WR51_29090 ENOG4105D7V transposase WR51_29105 ENOG4107VMI polysaccharide deacetylase WR51_29115 ENOG4108IMY Transcriptional regulator WR51_29140 ENOG4108JJA ABC, transporter WR51_29215 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR51_29230 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase WR51_29235 ENOG4105DR5 peptidase WR51_29240 ENOG41065S2 pneumococcal vaccine antigen WR51_29275 ENOG4105IIU Aminopeptidase WR51_29315 ENOG4107R0E Glycosyl transferase, family 2 WR51_29350 ENOG4108WZA zeta toxin WR51_29355 ENOG4105M6F mutator MutT protein WR51_29390 ENOG4107JM4 Tetratricopeptide repeat WR51_29400 ENOG4105YWU small acid-soluble spore protein WR51_29570 ENOG4105EKQ RNA-directed DNA polymerase WR51_29630 ENOG4108SHJ s-layer protein WR51_29765 ENOG4105E5W Transporter WR51_29785 ENOG41068WN WR51_29895 ENOG4105DHF Membrane WR51_29905 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C WR51_29950 ENOG4108M0I Transcriptional regulator WR51_30015 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WR51_30055 ENOG4105DQ6 Transposase WR51_30090 ENOG4105K70 DNA-binding protein WR51_30095 ENOG4105KRN Transcriptional regulator, abrb family WR51_30120 ENOG4105D7V transposase WR51_30125 ENOG4108UZ3 Transporter WR51_30130 ENOG4105DRR Transcriptional regulator, GntR family WR51_30135 ENOG4108UZ3 Transporter WR51_30145 ENOG4105E5W Transporter WR51_30150 ENOG4105CUJ penicillin amidase WR51_30190 ENOG4105CIF Ornithine Cyclodeaminase WR51_30205 ENOG4105K70 DNA-binding protein WR51_30215 ENOG4105KRN Transcriptional regulator, abrb family WR51_30220 ENOG4108KS4 Spore coat protein WR51_30225 ENOG4107SBE Glycosyl transferase (Group 1 WR51_30245 ENOG4107SBE Glycosyl transferase (Group 1 WR51_30250 ENOG4108IAJ Nad-dependent epimerase dehydratase WR51_30265 ENOG4105DUX Transporter WR51_30275 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR51_30280 ENOG4108594 Permease of the drug metabolite transporter WR51_30285 ENOG4105CHR reductase WR51_30305 ENOG4105FQP Beta-lactamase WR51_30365 ENOG4108IBT Inherit from COG: transposase WR51_30420 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin WR51_30425 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin WR51_30465 ENOG4108JGH Tetr family transcriptional regulator WR51_30470 ENOG4105EQ0 Major Facilitator superfamily WR51_30480 ENOG4105EJQ L-serine dehydratase WR51_30485 ENOG4105C44 Serine transporter WR51_30500 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer WR51_30520 ENOG41067SE Tetr family transcriptional regulator WR51_30540 ENOG4107SCK Monooxygenase WR51_30545 ENOG4105FQP Beta-lactamase WR51_30550 ENOG4105CNI cell division protein FtsW WR51_30555 ENOG4105CJW magnesium transporter WR51_30620 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity)