locus-tag class description WR47_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) WR47_00015 ENOG410848D S4 domain protein YaaA WR47_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WR47_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) WR47_00080 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) WR47_00100 ENOG4105ZMH deoxynucleoside kinase WR47_00110 ENOG4105GTG Isochorismatase WR47_00120 ENOG4108Z6B deaminase WR47_00125 ENOG4105C6E dna polymerase iii WR47_00145 ENOG41067KS pro-sigma K processing WR47_00180 ENOG4105CXN decarboxylase WR47_00190 ENOG4105FA2 dna polymerase iii WR47_00195 ENOG4105MA4 psp1 domain protein WR47_00205 ENOG41060K3 Methyltransferase WR47_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) WR47_00220 ENOG4105KRN Transcriptional regulator, abrb family WR47_00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) WR47_00230 ENOG4105F8V Hydrolase, tatD family WR47_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) WR47_00245 ENOG4105XFA sporulation peptidase YabG WR47_00250 ENOG4105W42 Veg protein WR47_00265 ENOG4105DFT pur operon repressor WR47_00270 ENOG4105KME endoribonuclease L-psp WR47_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase WR47_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) WR47_00300 ENOG4108JA2 transcriptioN-repair coupling factor WR47_00305 ENOG4108M14 stage v sporulation protein t WR47_00315 ENOG4108IY2 MazG family WR47_00320 ENOG41082I2 s4 domain protein WR47_00325 ENOG4105VYY sporulation protein yabp WR47_00340 ENOG41060GV RNA binding s1 domain protein WR47_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) WR47_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase WR47_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) WR47_00385 ENOG4105C6T cysteine synthase WR47_00390 ENOG4105CRQ synthase (Component I) WR47_00395 ENOG4105DDQ anthranilate synthase WR47_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 WR47_00405 ENOG4105EEI dihydropteroate synthase WR47_00410 ENOG4105KRF dihydroneopterin aldolase WR47_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase WR47_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) WR47_00515 ENOG4108Z0C Uvrb UvrC protein WR47_00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) WR47_00540 ENOG4105CTP PilT protein domain protein WR47_00560 ENOG4105D7W serine acetyltransferase WR47_00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 WR47_00580 ENOG4105M0M Tetracycline resistance protein WR47_00585 ENOG4105QIV RNA polymerase WR47_00600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) WR47_00620 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) WR47_00625 ENOG4107Y49 methyltransferase WR47_00635 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WR47_00640 ENOG4105XPM ribosomal protein WR47_00745 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) WR47_00770 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) WR47_00780 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) WR47_00790 ENOG41067V7 50S ribosomal protein L36 WR47_00815 ENOG4108JJB ABC transporter WR47_00820 ENOG4108JJB ABC transporter WR47_00825 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) WR47_00830 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) WR47_00855 ENOG4105D1F ATP-binding protein WR47_00870 ENOG4108NMV polysaccharide deacetylase WR47_00950 ENOG4105C8B TIGR00159 family WR47_00955 ENOG4107U5W ybbr family WR47_00970 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) WR47_00995 ENOG4108PSK reductase WR47_01000 ENOG4108UMI ABC transporter, permease WR47_01005 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WR47_01010 ENOG4105D01 (LipO)protein WR47_01015 ENOG4105CB2 alcohol dehydrogenase WR47_01025 ENOG4105IQ5 FAD linked oxidase domain protein WR47_01040 ENOG4105C2C drug resistance transporter, Bcr CflA WR47_01060 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WR47_01065 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WR47_01070 ENOG4105C3U ABC transporter WR47_01075 ENOG4108JQ7 (ABC) transporter WR47_01095 ENOG4108J59 Extracellular solute-binding protein, family 5 WR47_01100 ENOG4108J59 Extracellular solute-binding protein, family 5 WR47_01120 ENOG4106Z1T Nicotinamide Mononucleotide Transporter WR47_01130 ENOG4105E0C molybdate abc transporter WR47_01135 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein WR47_01140 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family WR47_01175 ENOG4105F6E Acyl-transferase WR47_01195 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) WR47_01215 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) WR47_01240 ENOG4105C5H ABC transporter WR47_01250 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein WR47_01260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WR47_01265 ENOG4105C3U ABC transporter WR47_01270 ENOG4108JQ7 (ABC) transporter WR47_01275 ENOG410667J hydrolase WR47_01305 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase WR47_01310 ENOG4105ERH Fumarylacetoacetate hydrolase WR47_01320 ENOG4105CUB amino acid WR47_01325 ENOG4108SC4 )-transporter WR47_01330 ENOG4105CPF Cell wall formation (By similarity) WR47_01335 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) WR47_01360 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein WR47_01365 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) WR47_01375 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) WR47_01480 ENOG4105K8N protein family UPF0079, ATPase WR47_01485 ENOG41072GX Peptidase M22 Glycoprotease WR47_01490 ENOG410801F ribosomal-protein-alanine acetyltransferase WR47_01495 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WR47_01500 ENOG4105C5H ABC transporter WR47_01515 ENOG4108TYN CAAX amino terminal protease family protein WR47_01530 ENOG4108IBT Inherit from COG: transposase WR47_01545 ENOG4105C7N Xanthine uracil vitamin C permease WR47_01555 ENOG4105BZU Histidine kinase WR47_01580 ENOG4107ZXU DSBA oxidoreductase WR47_01630 ENOG4107ZXU DSBA oxidoreductase WR47_01650 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR47_01705 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR47_01725 ENOG4105SX7 Transporter WR47_01755 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) WR47_01760 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit WR47_01765 ENOG4105C83 adenylosuccinate lyase WR47_01775 ENOG4105VR9 phosphoribosylformylglycinamidine synthase WR47_01800 ENOG4108V3E phosphoribosylglycinamide formyltransferase WR47_01810 ENOG4105C12 Phosphoribosylglycinamide synthetase WR47_01820 ENOG4105EGI Transcriptional regulator WR47_01845 ENOG4105C4R Atp-dependent dna helicase WR47_01850 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) WR47_01870 ENOG4108W2Y isochorismatase WR47_01880 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WR47_01885 ENOG4108UMI ABC transporter, permease WR47_01890 ENOG4105D01 (LipO)protein WR47_01910 ENOG410834F Transcriptional regulator WR47_01915 ENOG4107I77 yiaA/B two helix domain WR47_01935 ENOG4105CBD Diacylglycerol kinase WR47_01945 ENOG4108JPW Aminotransferase WR47_01955 ENOG4105C26 Dehydrogenase WR47_01960 ENOG4105KPY Small multidrug resistance protein WR47_01980 ENOG4105D9N nucleoside WR47_01985 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) WR47_01995 ENOG4108W15 Protein of unknown function (DUF1456) WR47_02010 ENOG4105DTQ mandelate racemase muconate lactonizing WR47_02020 ENOG4105DFD Na H antiporter WR47_02045 ENOG4105D3R alkyl hydroperoxide reductase WR47_02050 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) WR47_02055 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) WR47_02060 ENOG4107W7X Aldolase WR47_02065 ENOG4105EHG Permease protein WR47_02070 ENOG4105DQ5 transport system permease protein WR47_02075 ENOG4108V5C ABC transporter WR47_02085 ENOG4105CAY ferredoxin--nadp reductase WR47_02105 ENOG4106UIA WR47_02110 ENOG4106UIA WR47_02125 ENOG4105BZU Histidine kinase WR47_02145 ENOG410756H nucleotidyltransferase WR47_02150 ENOG4105D2S major facilitator superfamily WR47_02165 ENOG4105E5Q amino acid AbC transporter WR47_02170 ENOG4105EAB amino acid AbC transporter WR47_02180 ENOG4105C8Q Methyl-accepting chemotaxis WR47_02195 ENOG4105DBV ornithine carbamoyltransferase WR47_02205 ENOG4105C5B carbamate kinase WR47_02210 ENOG4108W63 CRP FNR family transcriptional regulator WR47_02220 ENOG4105DNP FAD linked oxidase domain protein WR47_02230 ENOG4105CI1 PTS System WR47_02245 ENOG4105C9U ATP-dependent DNA helicase RecQ WR47_02260 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter WR47_02280 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WR47_02285 ENOG4107Z6I Thiamine biosynthesis protein WR47_02295 ENOG4105C5H ABC transporter WR47_02325 ENOG41062JF Transcriptional regulator WR47_02340 ENOG4105DEU major facilitator superfamily WR47_02355 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) WR47_02370 ENOG4108N0M stress protein WR47_02375 ENOG4106FN3 tellurium resistance protein WR47_02380 ENOG4106FN3 tellurium resistance protein WR47_02385 ENOG4107TS3 membrane protein, TerC WR47_02390 ENOG4108TTB tellurium resistance protein WR47_02405 ENOG41068PA UPF0435 protein WR47_02410 ENOG4105KJF protein tyrosine phosphatase WR47_02420 ENOG4107U9T Pfam:Ribonuclease_BN WR47_02425 ENOG4105C59 p-type ATPase WR47_02430 ENOG4108IPJ Membrane WR47_02450 ENOG4107ZTW SNARE associated Golgi WR47_02465 ENOG410606W general stress protein WR47_02470 ENOG4105UPD Calcium Proton WR47_02505 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) WR47_02510 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) WR47_02520 ENOG4108JUB Transcriptional regulator WR47_02530 ENOG4108IQI permease WR47_02570 ENOG4108A04 Beta-lactamase WR47_02585 ENOG4107R51 Glycosyl transferase, family 2 WR47_02590 ENOG4107QQG Dehydrogenase WR47_02595 ENOG4105C3I Nad-dependent epimerase dehydratase WR47_02600 ENOG4105CKK Glycosyl transferase, family 2 WR47_02615 ENOG4105F1A Pyruvate formate-lyase WR47_02635 ENOG4105CI2 imidazolone-5-propionate hydrolase WR47_02640 ENOG4105ECP epimerase WR47_02670 ENOG41067AE Membrane-bound metal-dependent hydrolase WR47_02675 ENOG4105CEN a g-specific adenine glycosylase WR47_02680 ENOG4106BXE WR47_02700 ENOG4105BZ1 (ABC) transporter WR47_02705 ENOG4107NBY Membrane WR47_02710 ENOG4105CBC glutamate synthase WR47_02720 ENOG4108IUW ABC transporter WR47_02740 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WR47_02745 ENOG4105G5W regulator Fur family WR47_02865 ENOG4108JQC penicillin-binding protein 1A WR47_02870 ENOG4108R9S DSBA oxidoreductase WR47_02880 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) WR47_02890 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) WR47_02905 ENOG4105CYN Serine protein kinase WR47_02980 ENOG4105DQ6 Transposase WR47_03005 ENOG4105C94 Transporter WR47_03020 ENOG4105DZ6 Band 7 protein WR47_03030 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism WR47_03035 ENOG4108V9W transcriptional regulatory protein WR47_03040 ENOG4105D4T Citrate transporter WR47_03065 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator WR47_03070 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WR47_03075 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component WR47_03080 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component WR47_03085 ENOG4105BZ7 extracellular solute-binding protein family 1 WR47_03090 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) WR47_03095 ENOG4108STX response regulator WR47_03100 ENOG4105US7 Histidine kinase WR47_03125 ENOG4108MRH transcriptional regulatory protein WR47_03135 ENOG4105C6K Malic enzyme WR47_03145 ENOG4108UZ3 Transporter WR47_03150 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR47_03160 ENOG4105BZU Histidine kinase WR47_03165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR47_03175 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) WR47_03180 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) WR47_03185 ENOG4108JB9 formate dehydrogenase WR47_03205 ENOG4105CUB amino acid WR47_03220 ENOG4105C59 p-type ATPase WR47_03225 ENOG4105DAP Nicotinate phosphoribosyltransferase WR47_03255 ENOG41073R8 VanW family WR47_03260 ENOG4108KGH TRANSCRIPTIONal WR47_03265 ENOG4105D9N nucleoside WR47_03270 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase WR47_03275 ENOG4105C37 (CBS) domain WR47_03280 ENOG4108IJ0 Aspartate ammonia-lyase WR47_03285 ENOG4105DAA L-lactate WR47_03300 ENOG4105DUX Transporter WR47_03305 ENOG4108MES Periplasmic binding protein WR47_03310 ENOG4105DQ5 transport system permease protein WR47_03315 ENOG4108IHU transport system permease protein WR47_03320 ENOG4105E0A ABC, transporter WR47_03335 ENOG4105EXW epimerase dehydratase WR47_03340 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) WR47_03350 ENOG4107T89 von Willebrand factor, type A WR47_03355 ENOG4105GMT ATPase associated with various cellular activities aaa_5 WR47_03360 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WR47_03370 ENOG4105BZU Histidine kinase WR47_03375 ENOG4105D5Q Arginine ornithine antiporter WR47_03380 ENOG4107414 GntR family transcriptional regulator WR47_03385 ENOG4105C5Y PTS System WR47_03390 ENOG4105CG3 alpha amylase, catalytic region WR47_03405 ENOG4105E1K spore germination protein WR47_03415 ENOG4105CRN Aminoglycoside phosphotransferase WR47_03420 ENOG4105BZG amino acid carrier protein WR47_03425 ENOG4105CDA abc transporter atp-binding protein WR47_03430 ENOG4105CT1 (ABC) transporter WR47_03435 ENOG4105EAD ABC transporter WR47_03440 ENOG4105DRP amino acid AbC transporter WR47_03445 ENOG4108IQI permease WR47_03460 ENOG4105GFR rna polymerase sigma factor WR47_03470 ENOG4105D29 Helix-turn-helix type 11 domain protein WR47_03475 ENOG4105NAE bifunctional deaminase-reductase domain protein WR47_03480 ENOG4105BZU Histidine kinase WR47_03505 ENOG4105CHH sulfate transporter WR47_03510 ENOG41068KF Universal stress protein WR47_03520 ENOG4105DEF Extracellular solute-binding protein, family 5 WR47_03530 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WR47_03535 ENOG4108JQ7 (ABC) transporter WR47_03545 ENOG4105CXY transporter WR47_03550 ENOG41067TZ transcriptional regulator, MarR family WR47_03555 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR47_03560 ENOG4105ETE Transcriptional regulator (LacI family WR47_03565 ENOG4108RVA ribokinase WR47_03575 ENOG4105C2J ABC transporter WR47_03580 ENOG4105CNN ABC, transporter WR47_03585 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator WR47_03590 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) WR47_03625 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) WR47_03655 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) WR47_03660 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer WR47_03665 ENOG41069ER domain protein WR47_03670 ENOG4105VZ8 Transcriptional regulator WR47_03675 ENOG4107D63 WR47_03690 ENOG4105DUX Transporter WR47_03710 ENOG4105C85 amino acid WR47_03715 ENOG4105C7N Xanthine uracil vitamin C permease WR47_03730 ENOG4105MA6 gCN5-related N-acetyltransferase WR47_03750 ENOG4105CCU oxidase (Subunit III) WR47_03755 ENOG4105BZ9 Cytochrome C oxidase, subunit I WR47_03760 ENOG4105E2S oxidase) subunit II WR47_03780 ENOG4106CAD Protein of unknown function (DUF3311) WR47_03785 ENOG4105E1V na solute symporter WR47_03800 ENOG4108NHD germination protein WR47_03810 ENOG4105CE1 Ferrous iron transport protein b WR47_03815 ENOG4105CE1 Ferrous iron transport protein b WR47_03820 ENOG4105CE1 Ferrous iron transport protein b WR47_03825 ENOG4105CVA phosphate WR47_03830 ENOG4105C8U phosphate abc transporter WR47_03835 ENOG4105E2Z phosphate ABC transporter (Permease WR47_03965 ENOG41080XQ Signal transduction protein with cbs domains WR47_03990 ENOG4105ETU transcriptional activator (TenA WR47_04000 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WR47_04010 ENOG4108VEU Thiamine monophosphate synthase WR47_04015 ENOG41080HI glycine oxidase WR47_04030 ENOG4105D06 uba thif-type nad fad binding protein WR47_04035 ENOG4105DWF phosphomethylpyrimidine kinase WR47_04070 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) WR47_04085 ENOG4108INS Transcriptional regulator WR47_04100 ENOG4105DQ6 Transposase WR47_04110 ENOG4105C7N Xanthine uracil vitamin C permease WR47_04120 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein WR47_04135 ENOG4105K63 Thioredoxin WR47_04155 ENOG4108B31 Spore germination protein WR47_04175 ENOG4107Y03 Nitroreductase WR47_04180 ENOG4105ED1 spovr family WR47_04190 ENOG4105J4Q Transcriptional regulator WR47_04205 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase WR47_04210 ENOG4105XTG Pfam:DUF156 WR47_04215 ENOG4105VFE sira family WR47_04220 ENOG4107TPS domain protein WR47_04225 ENOG4105VFE sira family WR47_04230 ENOG41085GJ domain protein WR47_04240 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase WR47_04245 ENOG41087NI Sulfite exporter TauE/SafE WR47_04255 ENOG4108KGH TRANSCRIPTIONal WR47_04280 ENOG4105EMD TRANSCRIPTIONal WR47_04285 ENOG4105VCP PTS System WR47_04290 ENOG4105VZJ PTS System WR47_04310 ENOG41069ER domain protein WR47_04315 ENOG4107RBB ABC transporter, permease WR47_04320 ENOG4105C19 ABC transporter WR47_04350 ENOG4105WEF catalase WR47_04385 ENOG4107T5V SNARE associated Golgi WR47_04420 ENOG4105CUB amino acid WR47_04425 ENOG4107RWR Sodium hydrogen exchanger WR47_04435 ENOG4106KNT transcriptional regulator WR47_04475 ENOG4108YXU transcriptional regulator AsnC family WR47_04480 ENOG4105CH7 arginosuccinase WR47_04485 ENOG4105UBK short-chain dehydrogenase reductase WR47_04495 ENOG4105KPY Small multidrug resistance protein WR47_04535 ENOG4107RKG DJ-1/PfpI family WR47_04540 ENOG4105CH6 catalase WR47_04550 ENOG4105D5Q Arginine ornithine antiporter WR47_04555 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) WR47_04565 ENOG4105C26 Dehydrogenase WR47_04575 ENOG4105BZ1 (ABC) transporter WR47_04580 ENOG4105BZ1 (ABC) transporter WR47_04590 ENOG4105DRP amino acid AbC transporter WR47_04595 ENOG4105CDA abc transporter atp-binding protein WR47_04610 ENOG410839P WR47_04620 ENOG4108UH6 UPF0754 membrane protein WR47_04630 ENOG4105BZU Histidine kinase WR47_04635 ENOG4105WH1 Two component transcriptional regulator luxr family WR47_04650 ENOG4105D7V transposase WR47_04660 ENOG4107FQX Alpha-acetolactate decarboxylase WR47_04680 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR47_04685 ENOG4105D4P Coproporphyrinogen iii oxidase WR47_04690 ENOG4105CEY Amp-dependent synthetase and ligase WR47_04705 ENOG4105CHH sulfate transporter WR47_04730 ENOG4105CGU Enoyl-CoA hydratase WR47_04750 ENOG4105DER m42 family WR47_04770 ENOG4105CTU Proline racemase WR47_04775 ENOG4105CIF Ornithine Cyclodeaminase WR47_04795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WR47_04805 ENOG4108JQ7 (ABC) transporter WR47_04845 ENOG4105CSH Transporter WR47_04855 ENOG4108MRH transcriptional regulatory protein WR47_04925 ENOG4105CDU Replicative dna helicase WR47_04965 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR47_04975 ENOG4105D9U N-acetyltransferase WR47_04995 ENOG4107SWG transcriptional regulator MERR family WR47_05030 ENOG4108VJ1 Transcriptional regulator (CarD family WR47_05060 ENOG4105CJ1 ABC, transporter WR47_05090 ENOG4105T09 s-layer domain-containing protein WR47_05095 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WR47_05120 ENOG4105F6J Alpha beta hydrolase fold WR47_05170 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase WR47_05185 ENOG4105F27 Major Facilitator WR47_05190 ENOG4105WAB arsR family transcriptional regulator WR47_05200 ENOG4105CMT Dihydroxyacetone kinase WR47_05210 ENOG4105CMT Dihydroxyacetone kinase WR47_05305 ENOG4105WN5 stage II sporulation protein WR47_05315 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR47_05325 ENOG4108MJI response regulator WR47_05330 ENOG4105BZU Histidine kinase WR47_05335 ENOG4105BZU Histidine kinase WR47_05375 ENOG4107QHE Choloylglycine hydrolase WR47_05395 ENOG4107VRP DNA repair exonuclease WR47_05400 ENOG4106D4I domain protein WR47_05420 ENOG410829K Lysine exporter protein (Lyse ygga) WR47_05450 ENOG4108MUZ hydrolase WR47_05465 ENOG4105F0F Oxalate decarboxylase WR47_05470 ENOG41067QW Transcriptional regulator WR47_05475 ENOG4105D7V transposase WR47_05480 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator WR47_05495 ENOG4105C6V Glycerol-3-phosphate dehydrogenase WR47_05505 ENOG4105DU6 RNA polymerase WR47_05515 ENOG4105CNI cell division protein FtsW WR47_05520 ENOG4105EEM helicase WR47_05525 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WR47_05555 ENOG4105K59 histidine triad (HIT) protein WR47_05625 ENOG410905X membrane-flanked domain protein WR47_05630 ENOG4105CKV Membrane WR47_05680 ENOG410905X membrane-flanked domain protein WR47_05685 ENOG4105CKV Membrane WR47_05690 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation WR47_05695 ENOG4105BZ4 penicillin-binding protein WR47_05705 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) WR47_05710 ENOG4105C1Q protoporphyrinogen oxidase WR47_05735 ENOG4105NA0 Transcriptional regulator WR47_05750 ENOG4105ECB domain protein WR47_05770 ENOG4108MK9 spermidine N(1)-acetyltransferase WR47_05780 ENOG4106AXD WR47_05785 ENOG4108RQ5 Beta-lactamase domain-containing protein WR47_05790 ENOG4105DF9 Lipoate-protein, ligase WR47_05800 ENOG4105CEY Amp-dependent synthetase and ligase WR47_05810 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein WR47_05815 ENOG4108I5D sulfate abc transporter WR47_05820 ENOG4105ECW sulfate abc transporter WR47_05825 ENOG4108IJ6 ABC transporter WR47_05830 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) WR47_05840 ENOG4107RN3 metallophosphoesterase WR47_05845 ENOG4107TVP HD domain protein WR47_05855 ENOG4108AEY RNA polymerase sigma factor WR47_05860 ENOG41086D8 Transcriptional regulator WR47_05875 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR47_05895 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 WR47_05900 ENOG4105C8Q Methyl-accepting chemotaxis WR47_05905 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) WR47_05915 ENOG4107QP3 malate synthase g WR47_05935 ENOG4105VEQ Cold shock protein WR47_05970 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation WR47_05975 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WR47_06015 ENOG4105ERH Fumarylacetoacetate hydrolase WR47_06025 ENOG4105C8Y Acetylornithine aminotransferase WR47_06040 ENOG4105CAQ asparagine synthetase WR47_06045 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) WR47_06050 ENOG4105CH6 catalase WR47_06055 ENOG4105BZU Histidine kinase WR47_06075 ENOG4105QNR S1 RNA binding domain protein WR47_06080 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WR47_06090 ENOG4107AYK membrAne WR47_06095 ENOG41073B9 WR47_06105 ENOG4108KP7 hydrolase WR47_06120 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit WR47_06145 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) WR47_06150 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) WR47_06165 ENOG4105C31 Tryptophanyl-tRNA synthetase WR47_06180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WR47_06185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WR47_06195 ENOG4108JQ7 (ABC) transporter WR47_06200 ENOG4105UQX Mate efflux family protein WR47_06225 ENOG4108ZCF integral membrane protein WR47_06235 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WR47_06245 ENOG4105DPN Oligoendopeptidase f WR47_06260 ENOG4108Z18 K06886 hemoglobin WR47_06265 ENOG4105MIX Adenylate cyclase WR47_06270 ENOG4106EFP UPF0738 protein WR47_06280 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) WR47_06285 ENOG4105EMS pseudouridine synthase WR47_06305 ENOG4105K64 Glycosyl transferase, family 2 WR47_06325 ENOG4107TVC Glycosyl transferase, family 2 WR47_06345 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) WR47_06350 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase WR47_06360 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase WR47_06410 ENOG4108ZMI UPF0477 protein WR47_06445 ENOG4105CK7 Sodium proline symporter WR47_06455 ENOG4105CRQ synthase (Component I) WR47_06460 ENOG4105DDQ anthranilate synthase WR47_06470 ENOG4105DK0 Indole-3-glycerol phosphate synthase WR47_06475 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase WR47_06480 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) WR47_06565 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WR47_06585 ENOG4105C7S Dehydrogenase WR47_06590 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 WR47_06595 ENOG4105VZ8 Transcriptional regulator WR47_06660 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) WR47_06670 ENOG4105DZ1 carboxypeptidase WR47_06675 ENOG4105VFR signal peptidase WR47_06710 ENOG4105C26 Dehydrogenase WR47_06715 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WR47_06720 ENOG4105F38 ABC transporter, permease WR47_06725 ENOG4105D38 putrescine abc transporter WR47_06730 ENOG4107RUE extracellular solute-binding protein family 1 WR47_06740 ENOG4105EYF MMPL domain protein WR47_06750 ENOG4108YBP pseudouridine synthase WR47_06760 ENOG4105K4I Scp-like extracellular WR47_06765 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) WR47_06770 ENOG4105CQB FAD linked oxidase domain protein WR47_06785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR47_06790 ENOG4105BZU Histidine kinase WR47_06795 ENOG4105JXH GntR family transcriptional regulator WR47_06815 ENOG4106A3R peptidase WR47_06825 ENOG4108QTI )-transporter WR47_06830 ENOG4107TS3 membrane protein, TerC WR47_06835 ENOG4105CZN Potassium uptake protein WR47_06840 ENOG410681C small acid-soluble spore protein WR47_06845 ENOG4108Z7G MaoC domain protein dehydratase WR47_06865 ENOG4105CHR reductase WR47_06895 ENOG4105C4Y ABC transporter WR47_06900 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WR47_06905 ENOG4107RCV ABC transporter, permease WR47_06925 ENOG4105E98 transcriptional regulator DeoR family WR47_06940 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) WR47_06950 ENOG4105PXI polysaccharide deacetylase WR47_06960 ENOG4105BZU Histidine kinase WR47_06965 ENOG41090MY MarR family Transcriptional regulator WR47_06975 ENOG4106DF1 WR47_06985 ENOG4105BZU Histidine kinase WR47_06990 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) WR47_06995 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase WR47_07000 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) WR47_07050 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) WR47_07055 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WR47_07060 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WR47_07065 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family WR47_07070 ENOG4105CZV ABC transporter WR47_07080 ENOG4105CJ1 ABC, transporter WR47_07120 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A WR47_07125 ENOG4105EA8 2-Nitropropane dioxygenase WR47_07130 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD WR47_07140 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein WR47_07165 ENOG4105NQC Flavodoxin WR47_07205 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) WR47_07235 ENOG4105CZN Potassium uptake protein WR47_07240 ENOG41063Y9 WR47_07245 ENOG4105KBJ sporulation protein ytfj WR47_07275 ENOG4105CM2 brancheD-chain amino acid aminotransferase WR47_07280 ENOG4105C7K acetolactate synthase WR47_07285 ENOG4108ZP8 Acetolactate synthase small subunit WR47_07290 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase WR47_07305 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WR47_07325 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) WR47_07330 ENOG4105ECC imidazole-glycerol-phosphate dehydratase WR47_07335 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) WR47_07360 ENOG4107RVV histidinol phosphate phosphatase, hisj family WR47_07375 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase WR47_07380 ENOG4105E0M Sulfatase WR47_07390 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) WR47_07410 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) WR47_07415 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) WR47_07425 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WR47_07430 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein WR47_07435 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein WR47_07445 ENOG4105C8J )-transporter WR47_07465 ENOG4105DFD Na H antiporter WR47_07485 ENOG4105ENE Histidine kinase WR47_07490 ENOG4105WH1 Two component transcriptional regulator luxr family WR47_07510 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WR47_07535 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) WR47_07560 ENOG4105CJ3 phosphate transporter WR47_07565 ENOG4107GRR phosphate transport regulator WR47_07570 ENOG4105BZ4 penicillin-binding protein WR47_07585 ENOG4105BZU Histidine kinase WR47_07590 ENOG4105I3N Conserved Protein WR47_07605 ENOG4105BZU Histidine kinase WR47_07635 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WR47_07640 ENOG4105DZ1 carboxypeptidase WR47_07645 ENOG4108JIC nucleoside recognition domain protein WR47_07655 ENOG4105FE9 pseudouridine synthase WR47_07660 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WR47_07665 ENOG4107TWT Cytochrome c biogenesis protein WR47_07670 ENOG4105CRE cytochrome C WR47_07675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR47_07680 ENOG4105BZU Histidine kinase WR47_07685 ENOG4108WBT adenosyltransferase WR47_07700 ENOG4108SAX Membrane WR47_07715 ENOG4105C9U ATP-dependent DNA helicase RecQ WR47_07720 ENOG4105I7S Abortive infection protein WR47_07730 ENOG4107RGJ metallophosphoesterase WR47_07735 ENOG4108XDN Transcriptional regulator WR47_07740 ENOG4108S6Z Negative regulator of genetic competence WR47_07765 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase WR47_07770 ENOG4107RB3 L-asparaginase WR47_07805 ENOG4105S2F WR47_07810 ENOG41065D1 WR47_07840 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) WR47_07855 ENOG4105XXQ heptaprenyl diphosphate synthase component I WR47_07865 ENOG4105EAH synthase WR47_07870 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) WR47_07875 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase WR47_07890 ENOG41068YB TPR repeat-containing protein WR47_07905 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) WR47_07910 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) WR47_07945 ENOG4108JYZ YitT family WR47_07950 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase WR47_07965 ENOG4105FJR Lmbe family WR47_07970 ENOG4105CPK Glycosyl transferase (Group 1 WR47_07995 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) WR47_08010 ENOG4105DVT helicase WR47_08015 ENOG4105YAC WR47_08035 ENOG4105CSM endonuclease III WR47_08045 ENOG4105BZ4 penicillin-binding protein WR47_08085 ENOG4106F55 Protein of unknown function (DUF1273) WR47_08095 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) WR47_08105 ENOG4105DVT helicase WR47_08110 ENOG4105CTD carboxy-peptidase WR47_08120 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) WR47_08130 ENOG4105C2W permease WR47_08140 ENOG410890F Dynamin family WR47_08150 ENOG4108W0I acetyltransferase WR47_08160 ENOG4105KHC sulfurtransferase WR47_08205 ENOG4105HTX biosynthesis protein WR47_08235 ENOG4105CPK Glycosyl transferase (Group 1 WR47_08270 ENOG41081VK Ribonuclease WR47_08335 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WR47_08345 ENOG4107RWR Sodium hydrogen exchanger WR47_08350 ENOG4108Z5V transcriptional regulator, merr family WR47_08360 ENOG4105H67 Protein of unknown function (DUF421) WR47_08365 ENOG41080C8 DUF218 domain WR47_08375 ENOG4105DQ6 Transposase WR47_08435 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) WR47_08445 ENOG4107R0U MotA TolQ exbB proton channel WR47_08450 ENOG4105ER2 Ompa motb domain protein WR47_08455 ENOG4107YTP response regulator receiver protein WR47_08460 ENOG4105CBS Chea signal transduction histidine kinase WR47_08465 ENOG4105DD5 Flagellar motor switch protein WR47_08480 ENOG4105BZU Histidine kinase WR47_08500 ENOG4105E1Q flagellar hook-associated protein WR47_08505 ENOG4105DTJ flagellar hook-associated protein WR47_08525 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) WR47_08530 ENOG4108ZC9 flagellar basal-body rod protein flgc WR47_08535 ENOG41075Z6 flagellar hook-basal body complex protein fliE WR47_08540 ENOG4107U2N Flagellar M-ring protein WR47_08545 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WR47_08575 ENOG4105BZE flagellar hook protein, FlgE WR47_08590 ENOG4107R88 Chemotaxis protein (CheV) WR47_08605 ENOG4105I03 Flagellin WR47_08610 ENOG4105E4C Lytic transglycosylase catalytic WR47_08620 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WR47_08625 ENOG4105DD5 Flagellar motor switch protein WR47_08635 ENOG4105CN7 Flagellar biosynthetic protein FliP WR47_08640 ENOG4105VS8 Flagellar biosynthetic protein fliq WR47_08650 ENOG4105D00 flagellar biosynthetic protein flhB WR47_08655 ENOG4105D7B Flagellar biosynthesis protein flha WR47_08660 ENOG4105FZW flagellar biosynthesis regulator FlhF WR47_08665 ENOG4105KTQ flagellar basal-body rod protein WR47_08670 ENOG4105CPU Monooxygenase WR47_08675 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WR47_08710 ENOG4105KAC Antibiotic biosynthesis monooxygenase WR47_08735 ENOG4105DUM transcriptional regulator, lysR family WR47_08740 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WR47_08750 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component WR47_08780 ENOG4105CVJ phosphoglycerate mutase WR47_08790 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) WR47_08810 ENOG4105CAQ asparagine synthetase WR47_08830 ENOG4105PGM cation diffusion facilitator family transporter WR47_08840 ENOG4105DRR Transcriptional regulator, GntR family WR47_08845 ENOG4108UZ3 Transporter WR47_08855 ENOG4105CKI cobalamin synthesis protein WR47_08860 ENOG4108PJD permease WR47_08875 ENOG4105DFD Na H antiporter WR47_08880 ENOG4105VUF Transcriptional regulator WR47_08890 ENOG4105C9Q fumarate hydratase class II WR47_08915 ENOG4107QJQ Mate efflux family protein WR47_08920 ENOG4105EC3 peptidase S51, dipeptidase E WR47_08940 ENOG4107QIV Cytochrome c biogenesis protein WR47_08945 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WR47_08955 ENOG4107JM4 Tetratricopeptide repeat WR47_08970 ENOG4105BZC d-serine deaminase WR47_08975 ENOG4106BRA Membrane WR47_09010 ENOG4105CJ1 ABC, transporter WR47_09030 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) WR47_09040 ENOG4108IJ0 Aspartate ammonia-lyase WR47_09045 ENOG4105C6K Malic enzyme WR47_09110 ENOG4105FVX WR47_09115 ENOG4105E09 nadh pyrophosphatase WR47_09135 ENOG4105CSR polyphosphate kinase 2 WR47_09140 ENOG4105U3E Transcriptional regulator WR47_09150 ENOG4105DXI Major Facilitator superfamily WR47_09165 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) WR47_09170 ENOG4105EU0 Major facilitator Superfamily WR47_09175 ENOG4105C6T cysteine synthase WR47_09195 ENOG4105C8J )-transporter WR47_09205 ENOG4105X5K response regulator receiver protein WR47_09210 ENOG4105H67 Protein of unknown function (DUF421) WR47_09230 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) WR47_09235 ENOG4105CHR reductase WR47_09240 ENOG4105CM2 brancheD-chain amino acid aminotransferase WR47_09245 ENOG4105C7K acetolactate synthase WR47_09255 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase WR47_09260 ENOG4105C01 Dihydroxy-acid dehydratase WR47_09265 ENOG4105C7B Threonine dehydratase WR47_09290 ENOG4105C6X Major Facilitator WR47_09295 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b WR47_09305 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) WR47_09310 ENOG4105DY9 regulatoR WR47_09315 ENOG4105CYC Transferase WR47_09320 ENOG4105K5X acetyltransferase WR47_09380 ENOG41068WN WR47_09400 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) WR47_09415 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) WR47_09425 ENOG4105C0X amino acid WR47_09435 ENOG4106PZP Bacillus haemolytic enterotoxin (HBL) WR47_09470 ENOG410849A acetyltransferase, (GNAT) family WR47_09475 ENOG4105K8R UPF0145 protein WR47_09490 ENOG4107RHR regulatoR WR47_09500 ENOG4105D9N nucleoside WR47_09505 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) WR47_09535 ENOG410811B TRANSCRIPTIONal WR47_09550 ENOG4107RAQ aminopeptidase WR47_09560 ENOG4107R16 Multicopper oxidase WR47_09600 ENOG4108T5E Copper resistance protein WR47_09605 ENOG4105KTB nuclear export factor GLE1 WR47_09610 ENOG4107RT3 EamA-like transporter family WR47_09615 ENOG4105GZI Transcriptional regulator WR47_09620 ENOG4108Z40 Transcriptional regulator WR47_09625 ENOG4107ZXU DSBA oxidoreductase WR47_09630 ENOG4108TVJ Nitroreductase WR47_09640 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) WR47_09645 ENOG4106F5Q Membrane WR47_09650 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) WR47_09660 ENOG4105CKI cobalamin synthesis protein WR47_09670 ENOG4105C0Z ABC transporter WR47_09675 ENOG4108IV0 ABC, transporter WR47_09680 ENOG4105C32 Amino acid ABC transporter (Permease) WR47_09690 ENOG4105SKE transcriptional Regulator LysR family WR47_09700 ENOG4105MDS 4-oxalocrotonate tautomerase WR47_09720 ENOG4105C4M (Ubiquinol oxidase) subunit I WR47_09725 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii WR47_09730 ENOG4108JJ9 ABC, transporter WR47_09735 ENOG4108JJ8 (ABC) transporter WR47_09745 ENOG4105K64 Glycosyl transferase, family 2 WR47_09755 ENOG4108UT6 Transferase hexapeptide repeat containing protein WR47_09810 ENOG4105BZ1 (ABC) transporter WR47_09815 ENOG4105EFI regulatoR WR47_09820 ENOG4105BZU Histidine kinase WR47_09840 ENOG41075D4 Aminoglycoside 6-adenylyltransferase WR47_09845 ENOG4108ZJ4 polysaccharide deacetylase WR47_09865 ENOG4105D6E homoserine dehydrogenase WR47_09875 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) WR47_09890 ENOG4108KGH TRANSCRIPTIONal WR47_09900 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR47_09905 ENOG4105BZU Histidine kinase WR47_09910 ENOG4107VMI polysaccharide deacetylase WR47_09920 ENOG4105KT7 mgtC SapB transporter WR47_09925 ENOG4105VRR gCN5-related N-acetyltransferase WR47_09935 ENOG4105DUU IucA IucC family protein WR47_09940 ENOG4105CEY Amp-dependent synthetase and ligase WR47_09955 ENOG4108WBH protein TIM barrel WR47_09960 ENOG4105YWU small acid-soluble spore protein WR47_09970 ENOG4108ZUB Lysine exporter protein (Lyse ygga) WR47_09975 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR47_10025 ENOG4105KRN Transcriptional regulator, abrb family WR47_10035 ENOG4105YVS arsR family transcriptional regulator WR47_10040 ENOG4105CPC Aldo Keto reductase WR47_10070 ENOG4105C8Q Methyl-accepting chemotaxis WR47_10090 ENOG4108K88 Membrane WR47_10095 ENOG4108WPJ Ferritin-like domain WR47_10110 ENOG4105DEN Luciferase family WR47_10125 ENOG4105VMI -acetyltransferase WR47_10130 ENOG4107QM2 Aldo Keto reductase WR47_10135 ENOG4105CKI cobalamin synthesis protein WR47_10145 ENOG4105DSE periplasmic solute binding protein WR47_10155 ENOG4105K4T epimerase WR47_10165 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) WR47_10210 ENOG4107T5V SNARE associated Golgi WR47_10225 ENOG4108PJD permease WR47_10235 ENOG4108S4H thioesterase Superfamily protein WR47_10240 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WR47_10260 ENOG4105SXS Protein of unknown function (DUF456) WR47_10265 ENOG4105C37 (CBS) domain WR47_10285 ENOG4108Z7R Chaperone CsaA WR47_10305 ENOG4108ZRV stage ii sporulation protein p WR47_10315 ENOG4108VXD carboxy-peptidase WR47_10335 ENOG4105DQ6 Transposase WR47_10355 ENOG4108ZRV stage ii sporulation protein p WR47_10365 ENOG4108X4Q Hydrolase WR47_10370 ENOG41082F9 transcriptional regulator WR47_10375 ENOG4105D94 Major Facilitator Superfamily WR47_10385 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) WR47_10390 ENOG4107RBS Methyltransferase WR47_10405 ENOG41087PP glycosyltransferase MGT family WR47_10410 ENOG4108JYZ YitT family WR47_10415 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR47_10445 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) WR47_10495 ENOG4105KBJ sporulation protein ytfj WR47_10520 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WR47_10540 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) WR47_10545 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily WR47_10555 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein WR47_10560 ENOG4105EMN RNA polymerase sigma factor WR47_10575 ENOG4105CNW domain protein WR47_10585 ENOG4108V06 Glutathione peroxidase WR47_10600 ENOG4105C7R Atpase associated with various cellular activities aaa_3 WR47_10610 ENOG4108IUE nitrate reductase beta subunit WR47_10615 ENOG4105R3A Nitrate reductase WR47_10625 ENOG4107V6Q Cyclic nucleotide-binding domain WR47_10630 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WR47_10635 ENOG4105D06 uba thif-type nad fad binding protein WR47_10640 ENOG4105CVM Molybdenum cofactor synthesis domain protein WR47_10645 ENOG4108ZAF Molybdopterin WR47_10675 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein WR47_10680 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein WR47_10685 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WR47_10690 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit WR47_10695 ENOG4108IFG nitrite reductase, (NAD(P)H) WR47_10700 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) WR47_10735 ENOG4105MCT stage V sporulation protein S WR47_10760 ENOG4105C5H ABC transporter WR47_10775 ENOG4108UUM single-stranded DNA-binding protein WR47_10805 ENOG4107YX5 Pfam:DUF548 WR47_10810 ENOG4105C75 arginyL-tRNA synthetase WR47_10825 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) WR47_10850 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) WR47_10855 ENOG4105C5S asparaginyl-tRNA synthetase WR47_10875 ENOG4105EC2 ftsk spoIIIe WR47_10980 ENOG4105C8J )-transporter WR47_11000 ENOG4107XGZ Hydrolase WR47_11005 ENOG4105CY2 Citrate transporter WR47_11025 ENOG4105KD7 acetyltransferase WR47_11035 ENOG4105VMP Transcriptional regulator WR47_11040 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase WR47_11065 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 WR47_11080 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) WR47_11095 ENOG4107RVG penicillin-binding protein WR47_11105 ENOG4105E9Q Acyl-transferase WR47_11110 ENOG4108UT2 hemolysin iii WR47_11120 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) WR47_11130 ENOG4108RCR degv family WR47_11140 ENOG4108KF3 Electron transport protein SCO1 SenC WR47_11145 ENOG4107Y70 Heat shock protein WR47_11150 ENOG4105CAQ asparagine synthetase WR47_11165 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase WR47_11170 ENOG4108MES Periplasmic binding protein WR47_11175 ENOG4105F0I Aminotransferase WR47_11205 ENOG4105D8X mechanosensitive ion channel WR47_11210 ENOG4105BZU Histidine kinase WR47_11215 ENOG4105WH1 Two component transcriptional regulator luxr family WR47_11220 ENOG4106KNT transcriptional regulator WR47_11225 ENOG4107ZY0 Phenazine biosynthesis-like protein WR47_11245 ENOG4105CMG Carbohydrate kinase WR47_11250 ENOG4105C6Z Gluconate WR47_11260 ENOG4108YV3 Protein of unknown function (DUF2711) WR47_11290 ENOG4108IJ8 ABC transporter WR47_11295 ENOG4105E90 ABC transporter WR47_11330 ENOG4105C37 (CBS) domain WR47_11355 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WR47_11370 ENOG4107S4Y M20 DapE family protein YgeY WR47_11375 ENOG4108TSC N-acetyltransferase WR47_11380 ENOG4108JUB Transcriptional regulator WR47_11385 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein WR47_11430 ENOG410841Q phosphoesterase PA-phosphatase related protein WR47_11440 ENOG4105SZ6 Thioredoxin WR47_11505 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WR47_11560 ENOG4105BZ4 penicillin-binding protein WR47_11570 ENOG4105CZM Major Facilitator WR47_11575 ENOG4105W8X HesB YadR YfhF-family protein WR47_11585 ENOG4105DXD 2-methylcitrate dehydratase WR47_11590 ENOG4105CR4 methylisocitrate lyase WR47_11595 ENOG4105C1G acyl-Coa dehydrogenase WR47_11600 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WR47_11610 ENOG4105N14 lysine exporter protein LysE YggA WR47_11615 ENOG4105E39 Enoyl-CoA hydratase WR47_11630 ENOG4107RFY SbcCD D subunit WR47_11635 ENOG4105EYH Exonuclease WR47_11660 ENOG4105FCD Major Facilitator WR47_11665 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase WR47_11670 ENOG4105E4F Isochorismate synthase WR47_11675 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase WR47_11680 ENOG4105WQI isochorismatase WR47_11685 ENOG4105CEY Amp-dependent synthetase and ligase WR47_11690 ENOG4105WQT MbtH domain protein WR47_11695 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR47_11710 ENOG4105K70 DNA-binding protein WR47_11730 ENOG4105BZG amino acid carrier protein WR47_11750 ENOG4105FE9 pseudouridine synthase WR47_11755 ENOG4105C22 threonyL-tRNA synthetase WR47_11760 ENOG4105C19 ABC transporter WR47_11800 ENOG41081I9 integral membrane protein WR47_11810 ENOG4108Y4K DNA-binding transcriptional activator WR47_11825 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) WR47_11835 ENOG4105EYF MMPL domain protein WR47_11850 ENOG4105DQ6 Transposase WR47_11870 ENOG4105WCN acetyltransferase WR47_11895 ENOG4105C1Q protoporphyrinogen oxidase WR47_11905 ENOG41068WN WR47_11935 ENOG4107V2S Transcriptional regulator WR47_11940 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) WR47_11960 ENOG4105DND Transcriptional regulator WR47_11965 ENOG4108RPX mosc domain containing protein WR47_11980 ENOG4105BZ1 (ABC) transporter WR47_11985 ENOG4105BZ1 (ABC) transporter WR47_12005 ENOG4105VTR Integrase WR47_12065 ENOG4105KRN Transcriptional regulator, abrb family WR47_12145 ENOG4105CAR Terminase, large subunit WR47_12155 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) WR47_12225 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR47_12255 ENOG4108JCI Transcriptional regulator WR47_12290 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) WR47_12295 ENOG4108KPJ rna polymerase sigma factor WR47_12320 ENOG4105F32 YngK protein WR47_12340 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) WR47_12345 ENOG4105RD7 BadF BadG BcrA BcrD WR47_12350 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) WR47_12355 ENOG4107STF Involved in phosphonate degradation (By similarity) WR47_12360 ENOG4105C7B Threonine dehydratase WR47_12365 ENOG4108INS Transcriptional regulator WR47_12380 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) WR47_12390 ENOG4105C1J atp-dependent rna helicase WR47_12400 ENOG4108RZE Tetr family transcriptional regulator WR47_12495 ENOG41088CC tellurite resistance protein tehB WR47_12505 ENOG4108I0C methyltransferase WR47_12510 ENOG4107RA9 decarboxylase WR47_12515 ENOG4105K56 Transcriptional regulator WR47_12520 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) WR47_12565 ENOG4105CIN aminoacyl-histidine dipeptidase WR47_12595 ENOG4105KRN Transcriptional regulator, abrb family WR47_12605 ENOG4105EJ9 Membrane WR47_12610 ENOG4105EQK -acetyltransferase WR47_12650 ENOG4105W8Z 4'-phosphopantetheinyl transferase WR47_12670 ENOG4105CSV Glutaminase WR47_12690 ENOG4108Q8B Spore germination protein WR47_12695 ENOG4108NHD germination protein WR47_12700 ENOG4105II7 pyrroline-5-carboxylate reductase WR47_12705 ENOG4105CUB amino acid WR47_12710 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) WR47_12715 ENOG4105YWU small acid-soluble spore protein WR47_12720 ENOG41075H3 AraC family transcriptional regulator WR47_12745 ENOG4105BZU Histidine kinase WR47_12760 ENOG4108B31 Spore germination protein WR47_12810 ENOG4108IMY Transcriptional regulator WR47_12825 ENOG4107VMI polysaccharide deacetylase WR47_12830 ENOG4108RZE Tetr family transcriptional regulator WR47_12835 ENOG4105CAQ asparagine synthetase WR47_12840 ENOG4108XG2 Histidine kinase WR47_12850 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin WR47_12895 ENOG4107RVG penicillin-binding protein WR47_12910 ENOG4107RF6 penicillin-binding protein WR47_12915 ENOG4107RF6 penicillin-binding protein WR47_12925 ENOG4105DIN metallophosphoesterase WR47_12935 ENOG4105CJ1 ABC, transporter WR47_12945 ENOG4107Z3H Transcriptional regulator, TetR family WR47_12960 ENOG4105C1G acyl-Coa dehydrogenase WR47_12965 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase WR47_12970 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit WR47_12975 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase WR47_12980 ENOG4105E39 Enoyl-CoA hydratase WR47_12985 ENOG4107QX3 carboxylase WR47_12990 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WR47_13020 ENOG4105DZ1 carboxypeptidase WR47_13035 ENOG4105T9C HD domain WR47_13045 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) WR47_13065 ENOG41075H3 AraC family transcriptional regulator WR47_13095 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) WR47_13105 ENOG4107Y80 Major Facilitator superfamily WR47_13110 ENOG41061TZ Short-chain dehydrogenase reductase Sdr WR47_13115 ENOG4105KVH Transcriptional regulator WR47_13170 ENOG4105EFA 4-hydroxyphenylacetate WR47_13185 ENOG4105CPQ Dehydrogenase WR47_13195 ENOG410900G Protein of unknown function (DUF421) WR47_13200 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) WR47_13205 ENOG4108V4B ThiJ pfpI WR47_13215 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein WR47_13225 ENOG4105DK7 lysyl-tRNA synthetase WR47_13295 ENOG4105D6E homoserine dehydrogenase WR47_13305 ENOG4105CPF Cell wall formation (By similarity) WR47_13310 ENOG4105ETU transcriptional activator (TenA WR47_13335 ENOG4105VTR Integrase WR47_13360 ENOG4108IMY Transcriptional regulator WR47_13410 ENOG4105KRN Transcriptional regulator, abrb family WR47_13535 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) WR47_13600 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis WR47_13690 ENOG410667J hydrolase WR47_13695 ENOG4105BZU Histidine kinase WR47_13700 ENOG4107RF6 penicillin-binding protein WR47_13725 ENOG4108JJB ABC transporter WR47_13735 ENOG4108HGU Histidine kinase WR47_13800 ENOG4105CB2 alcohol dehydrogenase WR47_13805 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase WR47_13810 ENOG4105CJN penicillin-binding protein WR47_13820 ENOG4105FQP Beta-lactamase WR47_13865 ENOG4107Y80 Major Facilitator superfamily WR47_13880 ENOG4107VXM glycerophosphoryl diester phosphodiesterase WR47_13905 ENOG4107Y9U Membrane WR47_13950 ENOG4105FCD Major Facilitator WR47_13960 ENOG4105E09 nadh pyrophosphatase WR47_13965 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) WR47_14000 ENOG4108XI2 Domain of unknown function (DUF1963) WR47_14025 ENOG4108NRW Phospholipase, patatin family WR47_14030 ENOG4105KWG Pfam:DUF1696 WR47_14065 ENOG4105PKS Excinuclease abc c subunit domain protein WR47_14105 ENOG4107VFR oxidoreductase WR47_14130 ENOG4105U0R haloacid dehalogenase-like hydrolase WR47_14135 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR47_14140 ENOG4105BZU Histidine kinase WR47_14150 ENOG4105XDF Protein of unknown function (DUF1272) WR47_14175 ENOG4107WD8 ABC transporter, permease WR47_14190 ENOG4105DY8 decarboxylase WR47_14205 ENOG4108IUM Glycogen debranching enzyme WR47_14215 ENOG4105CGH 5'-nucleotidase WR47_14230 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) WR47_14240 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) WR47_14245 ENOG4105FDR Membrane WR47_14255 ENOG4105CIS alcohol dehydrogenase WR47_14260 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) WR47_14305 ENOG4105MSI germination protein ypeb WR47_14335 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) WR47_14340 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) WR47_14345 ENOG4107Z3H Transcriptional regulator, TetR family WR47_14375 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family WR47_14395 ENOG4105E98 transcriptional regulator DeoR family WR47_14410 ENOG41062ES Transcriptional regulator WR47_14430 ENOG4107QKR Dehydrogenase WR47_14440 ENOG4107RUY (E1 component), alpha subunit WR47_14450 ENOG4105E1F short-chain dehydrogenase reductase WR47_14455 ENOG4105RHY Pfam:UPF0157 WR47_14495 ENOG4107SQ8 Glycine betaine WR47_14500 ENOG4108IJ7 Glycine betaine WR47_14525 ENOG4105E66 phosphoriboisomerase A WR47_14530 ENOG41082BV acetyltransferase WR47_14535 ENOG4108M1A Chitin-binding protein WR47_14565 ENOG4105MSB protein, conserved in bacteria WR47_14585 ENOG4108Z7F N-acetyltransferase WR47_14610 ENOG4105KEG ribosomal-protein-alanine acetyltransferase WR47_14615 ENOG4105EEM helicase WR47_14630 ENOG4105C9U ATP-dependent DNA helicase RecQ WR47_14655 ENOG4105DQ6 Transposase WR47_14690 ENOG4108M1A Chitin-binding protein WR47_14710 ENOG4105BZG amino acid carrier protein WR47_14715 ENOG4105C26 Dehydrogenase WR47_14720 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WR47_14725 ENOG4105CTU Proline racemase WR47_14730 ENOG4105CTU Proline racemase WR47_14735 ENOG41080HI glycine oxidase WR47_14745 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein WR47_14775 ENOG4107T5V SNARE associated Golgi WR47_14785 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD WR47_14800 ENOG4105DTQ mandelate racemase muconate lactonizing WR47_14815 ENOG4107SET aldo keto reductase WR47_14820 ENOG4105ECQ AraC Family Transcriptional Regulator WR47_14845 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) WR47_14850 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WR47_14855 ENOG4105BZU Histidine kinase WR47_14860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR47_14900 ENOG4105DPN Oligoendopeptidase f WR47_14905 ENOG4105EPR degv family WR47_14965 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) WR47_14970 ENOG4106K7D Major facilitator family transporter WR47_14995 ENOG4107BMA Transglycosylase associated protein WR47_15010 ENOG41089UC methyltransferase, type 11 WR47_15050 ENOG4105CHM Aminotransferase WR47_15065 ENOG4108ZMI UPF0477 protein WR47_15080 ENOG4105DVE abc transporter atp-binding protein WR47_15140 ENOG4105C02 permease WR47_15155 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) WR47_15160 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component WR47_15165 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein WR47_15170 ENOG4105D7T ABC transporter WR47_15205 ENOG4108AQF aminoglycoside N(3)-acetyltransferase WR47_15240 ENOG4107VC0 DNA alkylation repair enzyme WR47_15245 ENOG4105C6T cysteine synthase WR47_15250 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase WR47_15265 ENOG4107VMI polysaccharide deacetylase WR47_15270 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC WR47_15280 ENOG4106ETB IIa component WR47_15285 ENOG4108ZCF integral membrane protein WR47_15290 ENOG4105E0M Sulfatase WR47_15295 ENOG4105C5H ABC transporter WR47_15300 ENOG4105EYF MMPL domain protein WR47_15305 ENOG41082JN Transcriptional regulator WR47_15310 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) WR47_15335 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase WR47_15340 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase WR47_15385 ENOG41069ER domain protein WR47_15395 ENOG4105DNP FAD linked oxidase domain protein WR47_15420 ENOG4105D4B ABC, transporter WR47_15425 ENOG4105F5R ABC transporter WR47_15430 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane WR47_15440 ENOG4105DKT Transcriptional regulator WR47_15445 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) WR47_15455 ENOG41061GT Aldolase WR47_15465 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) WR47_15495 ENOG4105II7 pyrroline-5-carboxylate reductase WR47_15505 ENOG4107258 Transcriptional regulator WR47_15525 ENOG4105ECK Fatty Acid Desaturase WR47_15535 ENOG4107RBI VanW family WR47_15540 ENOG4105G6Z alkaline phosphatase WR47_15550 ENOG4105VMP Transcriptional regulator WR47_15575 ENOG41068WN WR47_15605 ENOG4105C7R Atpase associated with various cellular activities aaa_3 WR47_15625 ENOG4105C8Y Acetylornithine aminotransferase WR47_15665 ENOG4108TVJ Nitroreductase WR47_15670 ENOG4105FS7 Transcriptional regulator WR47_15705 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family WR47_15715 ENOG4105CMR udp-glucose 4-epimerase WR47_15730 ENOG4108DMH HTH_ARAC WR47_15735 ENOG4108XET gCN5-related N-acetyltransferase WR47_15750 ENOG4108PCN EamA-like transporter family WR47_15795 ENOG410635A Membrane WR47_15805 ENOG4108IQI permease WR47_15815 ENOG4105F1N DNA alkylation repair WR47_15850 ENOG4107RF6 penicillin-binding protein WR47_15855 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) WR47_15860 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) WR47_15875 ENOG4105E7W lamb ycsf family protein WR47_15885 ENOG4105P4J Allophanate hydrolase, subunit 1 WR47_15890 ENOG4107258 Transcriptional regulator WR47_15905 ENOG4106N3A copper homeostasis protein cutc WR47_15910 ENOG4108ZHR arsR family transcriptional regulator WR47_15920 ENOG4105FDT acyl-CoA dehydrogenase WR47_15935 ENOG4105DWD nucleoside recognition domain protein WR47_15980 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) WR47_16005 ENOG4105E2A Dehydrogenase WR47_16015 ENOG4105CN5 Metallo-Beta-Lactamase WR47_16025 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WR47_16040 ENOG4105CGH 5'-nucleotidase WR47_16050 ENOG4105CHJ isochorismatase hydrolase WR47_16075 ENOG41090MY MarR family Transcriptional regulator WR47_16115 ENOG4108606 TspO/MBR family WR47_16120 ENOG4105CVP deoxyribo-dipyrimidine photolyase WR47_16145 ENOG4108TWJ NADH dehydrogenase subunit 5 WR47_16150 ENOG4105GPN Uncharacterized conserved protein (DUF2294) WR47_16155 ENOG4107VMI polysaccharide deacetylase WR47_16160 ENOG4105KY5 gCN5-related N-acetyltransferase WR47_16165 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase WR47_16170 ENOG4105ECQ AraC Family Transcriptional Regulator WR47_16185 ENOG4105D6J arsenicaL-resistance protein WR47_16190 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase WR47_16195 ENOG41085FC arsR family transcriptional regulator WR47_16230 ENOG4108IG5 Transcriptional regulator WR47_16235 ENOG4105F27 Major Facilitator WR47_16240 ENOG4105M4P Tetr family transcriptional regulator WR47_16245 ENOG4105CHR reductase WR47_16250 ENOG4108YXU transcriptional regulator AsnC family WR47_16295 ENOG4105C44 Serine transporter WR47_16300 ENOG4105DUM transcriptional regulator, lysR family WR47_16305 ENOG4105DWP Membrane WR47_16330 ENOG4105CZV ABC transporter WR47_16335 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family WR47_16345 ENOG4105N0V mono-oxygenase ydhR WR47_16380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR47_16385 ENOG41062D9 Histidine kinase WR47_16455 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) WR47_16460 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR47_16485 ENOG4105K6H D-cysteine desulfhydrase WR47_16495 ENOG4105E0Y RtcB Protein WR47_16505 ENOG4105JQZ Methyltransferase WR47_16525 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) WR47_16545 ENOG4105BZU Histidine kinase WR47_16555 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) WR47_16565 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A WR47_16585 ENOG4108JQ1 Dehydrogenase WR47_16590 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) WR47_16605 ENOG41082W1 Cupin 2, conserved barrel domain protein WR47_16610 ENOG410874W AraC family transcriptional regulator WR47_16630 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR47_16635 ENOG4108IG5 Transcriptional regulator WR47_16660 ENOG4108VXD carboxy-peptidase WR47_16665 ENOG4105PNM synthesis protein WR47_16675 ENOG4108ISG Major Facilitator WR47_16690 ENOG4107MII Sugar-specific transcriptional regulator TrmB WR47_16695 ENOG4105CZM Major Facilitator WR47_16710 ENOG4105DA5 (ABC) transporter WR47_16715 ENOG41069JR WR47_16725 ENOG4105RXJ WR47_16730 ENOG4105KPY Small multidrug resistance protein WR47_16735 ENOG4105KBX Transcriptional regulator, TetR family WR47_16755 ENOG4105CRW Short chain fatty acid transporter WR47_16765 ENOG4105DYS nad(p)h dehydrogenase (quinone) WR47_16800 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) WR47_16825 ENOG4108K8S endonuclease I WR47_16855 ENOG4108Z66 YbaK ebsC protein WR47_16875 ENOG4105KVH Transcriptional regulator WR47_16880 ENOG4108RCM Nitroreductase WR47_16910 ENOG4108PSK reductase WR47_16985 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase WR47_16990 ENOG4105DKQ ROK family WR47_17000 ENOG4108UW5 maltose o-acetyltransferase WR47_17005 ENOG4105C31 Tryptophanyl-tRNA synthetase WR47_17015 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR47_17020 ENOG41089BK Glutamine amido-transferase WR47_17050 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) WR47_17060 ENOG4105EV4 Multidrug resistance protein mdtH WR47_17100 ENOG4105C37 (CBS) domain WR47_17115 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase WR47_17120 ENOG4105FAW cDP-glucose 4,6-dehydratase WR47_17150 ENOG4105DDN Pentapeptide repeat-containing protein WR47_17155 ENOG4105XDF Protein of unknown function (DUF1272) WR47_17160 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) WR47_17165 ENOG4105CMG Carbohydrate kinase WR47_17170 ENOG4105C6Z Gluconate WR47_17185 ENOG4105CV1 Transketolase (EC 2.2.1.1) WR47_17190 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase WR47_17195 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase WR47_17215 ENOG41090KN UPF0303 protein WR47_17230 ENOG4105C44 Serine transporter WR47_17260 ENOG4108TZY GntR Family Transcriptional Regulator WR47_17265 ENOG4105D9R oxidoreductase WR47_17305 ENOG4105JAB phenazine biosynthesis protein, phzf family WR47_17315 ENOG4105KNA -acetyltransferase WR47_17325 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein WR47_17330 ENOG4105KVH Transcriptional regulator WR47_17335 ENOG4107SCK Monooxygenase WR47_17350 ENOG4105DQ6 Transposase WR47_17360 ENOG4108ZJ4 polysaccharide deacetylase WR47_17450 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) WR47_17460 ENOG4107YXZ hydrolase, family 25 WR47_17495 ENOG4105H3G oxidoreductase WR47_17530 ENOG4105CIS alcohol dehydrogenase WR47_17565 ENOG4108TN2 lmbE family WR47_17575 ENOG4107R3E Citrate transporter WR47_17590 ENOG4108MES Periplasmic binding protein WR47_17595 ENOG4105EHG Permease protein WR47_17600 ENOG4105DQ5 transport system permease protein WR47_17605 ENOG4105NX3 Membrane WR47_17625 ENOG4105D9U N-acetyltransferase WR47_17630 ENOG4107CUJ Protein of unknown function (DUF2690) WR47_17640 ENOG4107V2S Transcriptional regulator WR47_17660 ENOG4105C98 muts2 protein WR47_17670 ENOG4105E5K Alpha-amylase WR47_17675 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase WR47_17680 ENOG4105DPN Oligoendopeptidase f WR47_17710 ENOG4108A04 Beta-lactamase WR47_17735 ENOG4107VXM glycerophosphoryl diester phosphodiesterase WR47_17780 ENOG41082BM Transcriptional regulator, arsr family WR47_17785 ENOG4105CIS alcohol dehydrogenase WR47_17790 ENOG4105CNG UPF0061 protein WR47_17795 ENOG4107JM4 Tetratricopeptide repeat WR47_17820 ENOG4105CQB FAD linked oxidase domain protein WR47_17835 ENOG4107TPS domain protein WR47_17840 ENOG4105CEP NADH dehydrogenase WR47_17855 ENOG4108QXE glycerophosphoryl diester phosphodiesterase WR47_17890 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C WR47_17895 ENOG4108M1A Chitin-binding protein WR47_17905 ENOG4105E1K spore germination protein WR47_17925 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase WR47_17935 ENOG4108IAJ Nad-dependent epimerase dehydratase WR47_17940 ENOG4105FAW cDP-glucose 4,6-dehydratase WR47_17945 ENOG4105D7V transposase WR47_18000 ENOG4105BZU Histidine kinase WR47_18005 ENOG4105C5H ABC transporter WR47_18010 ENOG41067SE Tetr family transcriptional regulator WR47_18015 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity WR47_18025 ENOG4108VXD carboxy-peptidase WR47_18030 ENOG4107DUR UPF0457 protein WR47_18050 ENOG4105BZU Histidine kinase WR47_18060 ENOG4105KT7 mgtC SapB transporter WR47_18070 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase WR47_18075 ENOG41073R8 VanW family WR47_18085 ENOG4108R1P WR47_18105 ENOG4105VEQ Cold shock protein WR47_18125 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) WR47_18145 ENOG410904N short-chain dehydrogenase reductase WR47_18155 ENOG4106IQC argininosuccinate lyase WR47_18170 ENOG4108IA2 Sodium pantothenate symporter WR47_18180 ENOG4105C26 Dehydrogenase WR47_18185 ENOG4105CHR reductase WR47_18195 ENOG4105EWU Squalene--hopene cyclase WR47_18205 ENOG4105FR1 rard protein WR47_18210 ENOG410696E Membrane WR47_18225 ENOG4105D1F ATP-binding protein WR47_18235 ENOG4108ZAF Molybdopterin WR47_18240 ENOG4105CVM Molybdenum cofactor synthesis domain protein WR47_18245 ENOG4105D06 uba thif-type nad fad binding protein WR47_18250 ENOG4105TMB Formate nitrite transporter WR47_18260 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) WR47_18265 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) WR47_18275 ENOG4108JB9 formate dehydrogenase WR47_18285 ENOG4105E1K spore germination protein WR47_18300 ENOG4105CUB amino acid WR47_18350 ENOG4105DQ6 Transposase WR47_18365 ENOG4108KGH TRANSCRIPTIONal WR47_18375 ENOG4105EMN RNA polymerase sigma factor WR47_18385 ENOG4105CIG ABC transporter WR47_18405 ENOG4105D9R oxidoreductase WR47_18415 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WR47_18425 ENOG4105K4P CoA-binding domain protein WR47_18430 ENOG4105C0H protease WR47_18435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR47_18445 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase WR47_18450 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) WR47_18455 ENOG4105W8X HesB YadR YfhF-family protein WR47_18480 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) WR47_18485 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WR47_18495 ENOG4108JJA ABC, transporter WR47_18500 ENOG4108I0Z Aconitate hydratase WR47_18530 ENOG4105E5W Transporter WR47_18540 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WR47_18560 ENOG4107F3J Amp-dependent synthetase and ligase WR47_18565 ENOG4107ZYJ bioY protein WR47_18570 ENOG4105CEY Amp-dependent synthetase and ligase WR47_18580 ENOG4105BZU Histidine kinase WR47_18595 ENOG4105C19 ABC transporter WR47_18610 ENOG4105CJ1 ABC, transporter WR47_18700 ENOG4107AYK membrAne WR47_18710 ENOG4105BZU Histidine kinase WR47_18715 ENOG4105FBA Phospholipase Carboxylesterase WR47_18720 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase WR47_18725 ENOG4105CK7 Sodium proline symporter WR47_18730 ENOG4105CBC glutamate synthase WR47_18735 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WR47_18740 ENOG4108VJ1 Transcriptional regulator (CarD family WR47_18745 ENOG4108903 Formimidoylglutamase WR47_18770 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) WR47_18805 ENOG4107QIV Cytochrome c biogenesis protein WR47_18815 ENOG4105CH2 amidohydrolase WR47_18825 ENOG4105CJ1 ABC, transporter WR47_18840 ENOG4107RSM transcriptional regulator WR47_18845 ENOG4105VAW lrga family WR47_18850 ENOG41067MG lrgb family WR47_18890 ENOG4105BZ1 (ABC) transporter WR47_18895 ENOG4105BZ1 (ABC) transporter WR47_18930 ENOG4108HW3 (ABC) transporter WR47_18935 ENOG4105CGH 5'-nucleotidase WR47_18945 ENOG4108SVB resolvase WR47_18965 ENOG4105K7K Transcriptional regulator WR47_18975 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase WR47_19015 ENOG4105C5F glutamine synthetase WR47_19020 ENOG4105KV4 Transcriptional regulator WR47_19025 ENOG4105CXI aluminum resistance protein WR47_19030 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) WR47_19035 ENOG4105EN6 Membrane WR47_19045 ENOG4106F1P AAA ATPase, central domain protein WR47_19075 ENOG41069ER domain protein WR47_19080 ENOG4105DM4 PTS System WR47_19085 ENOG4105DE4 1-phosphofructokinase WR47_19090 ENOG4105E98 transcriptional regulator DeoR family WR47_19095 ENOG4107QW4 alcohol dehydrogenase WR47_19100 ENOG4108SJC Membrane WR47_19115 ENOG4105C85 amino acid WR47_19135 ENOG4105TMB Formate nitrite transporter WR47_19140 ENOG4105K70 DNA-binding protein WR47_19150 ENOG4105C59 p-type ATPase WR47_19155 ENOG410681U heavy metal transport detoxification protein WR47_19160 ENOG4105DQ6 Transposase WR47_19170 ENOG4105VPX protein, conserved in bacteria WR47_19180 ENOG4105NIV Esterase WR47_19185 ENOG4105E0A ABC, transporter WR47_19205 ENOG4105CGK Exodeoxyribonuclease III WR47_19215 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) WR47_19220 ENOG4105D03 DNA-3-methyladenine glycosylase II WR47_19250 ENOG4105BZU Histidine kinase WR47_19290 ENOG41067MG lrgb family WR47_19310 ENOG4108S3Y transcriptional regulator WR47_19315 ENOG4105CS2 ec 3.2.1.21 WR47_19330 ENOG4105F0V Cell wall hydrolase WR47_19340 ENOG4105E0M Sulfatase WR47_19345 ENOG410890F Dynamin family WR47_19380 ENOG4105DQU oxidoreductase, subunit beta WR47_19385 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein WR47_19390 ENOG4108IGT Dipeptidase WR47_19395 ENOG4105MCT stage V sporulation protein S WR47_19400 ENOG4105D48 metallophosphoesterase WR47_19425 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase WR47_19440 ENOG4105XZV Protein of unknown function (DUF3243) WR47_19445 ENOG4108RKS Short-chain dehydrogenase reductase Sdr WR47_19465 ENOG4105UIB (ABC) transporter WR47_19470 ENOG4108JQ9 ABC transporter WR47_19475 ENOG4105DIH basic membrane WR47_19480 ENOG4105FDP GntR family transcriptional regulator WR47_19490 ENOG4105CNU cell division protein FtsK WR47_19500 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit WR47_19510 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WR47_19520 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) WR47_19525 ENOG4108S0H Dipicolinic acid synthetase, b subunit WR47_19600 ENOG4105CDU Replicative dna helicase WR47_19660 ENOG4105E35 Dipicolinate synthase subunit A WR47_19670 ENOG4105C1V Peptidase, M16 WR47_19690 ENOG4105DTN riboflavin biosynthesis protein ribF WR47_19705 ENOG4105W7A Protein of unknown function (DUF503) WR47_19715 ENOG4105VHM ribosomal protein WR47_19720 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination WR47_19725 ENOG4105CHV Transcription elongation factor NusA WR47_19735 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) WR47_19745 ENOG4105DZP Membrane-associated zinc metalloprotease WR47_19750 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) WR47_19755 ENOG4105KNE Phosphatidate cytidylyltransferase WR47_19760 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) WR47_19770 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) WR47_19800 ENOG4108HE4 integrase family WR47_19810 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) WR47_19815 ENOG4105C79 DNA protecting protein DprA WR47_19820 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha WR47_19835 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) WR47_19860 ENOG4105VB6 UPF0109 protein WR47_19880 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) WR47_19885 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) WR47_19900 ENOG4105CHR reductase WR47_19905 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase WR47_19920 ENOG4105CB5 ATP-dependent DNA helicase recG WR47_19925 ENOG4105DP4 dak2 domain fusion protein ylov WR47_19930 ENOG4108ZAA Alkaline-shock protein WR47_19945 ENOG4105FJ0 thiamine WR47_19950 ENOG4105DJV ribulose-phosphate 3-epimerase WR47_19955 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) WR47_19960 ENOG4105D9P serine threonine protein kinase WR47_19965 ENOG4108ZF3 Phosphatase WR47_19975 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B WR47_19990 ENOG4105C25 Primosomal protein n' WR47_19995 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase WR47_20015 ENOG4105DSJ YicC domain protein WR47_20025 ENOG4105F23 Fibronectin-binding protein WR47_20035 ENOG4105DC7 peptidase M24 WR47_20085 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) WR47_20120 ENOG4105C34 Pseudouridine synthase WR47_20135 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) WR47_20145 ENOG4105DBK s4 domain protein WR47_20150 ENOG41067XK integral membrane protein WR47_20160 ENOG4105DFA alanine racemase domain protein WR47_20165 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase WR47_20170 ENOG4105WR5 sporulation protein, YlmC YmxH family WR47_20180 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR47_20190 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) WR47_20195 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) WR47_20205 ENOG4105D4A Cell wall formation (By similarity) WR47_20210 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) WR47_20215 ENOG4105CNI cell division protein FtsW WR47_20230 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) WR47_20235 ENOG4105CJN penicillin-binding protein WR47_20240 ENOG4105CJN penicillin-binding protein WR47_20255 ENOG41074B2 UPF0747 protein WR47_20280 ENOG4105KNH Nucleic acid-binding protein WR47_20290 ENOG41063PX domain protein WR47_20295 ENOG4105D78 K07001 NTE family protein WR47_20300 ENOG4105H20 Sporulation integral membrane protein YlbJ WR47_20310 ENOG4106H78 methyltransferase WR47_20330 ENOG4107TB6 phosphoglycerate mutase WR47_20345 ENOG4106UY4 Inherit from COG: Scp-like extracellular WR47_20395 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) WR47_20400 ENOG4105CNI cell division protein FtsW WR47_20415 ENOG4108IAB Phoh family WR47_20435 ENOG4105QA2 WR47_20440 ENOG4105CI3 gtp-binding protein typa WR47_20450 ENOG4105ECY inositol monophosphatase WR47_20470 ENOG4105CXN decarboxylase WR47_20520 ENOG4105CPP Dehydrogenase, E1 component WR47_20535 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) WR47_20540 ENOG4108X4Q Hydrolase WR47_20550 ENOG4105CN5 Metallo-Beta-Lactamase WR47_20555 ENOG4107ZYR domain protein WR47_20590 ENOG4108XRC Protein of unknown function (DUF458) WR47_20600 ENOG4107IN1 Protein of unknown function (DUF1797) WR47_20615 ENOG4105EPM Diguanylate phosphodiesterase WR47_20620 ENOG4105K6S Short-chain dehydrogenase reductase Sdr WR47_20635 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) WR47_20645 ENOG4105UIN WR47_20685 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) WR47_20705 ENOG4108HGU Histidine kinase WR47_20715 ENOG4105CHM Aminotransferase WR47_20720 ENOG4105FKQ transcriptional regulator WR47_20725 ENOG4105EG2 ABC transporter, permease WR47_20735 ENOG4107FKK extracellular solute-binding protein family 1 WR47_20745 ENOG4105CG3 alpha amylase, catalytic region WR47_20790 ENOG4105CHU acetyl-coa acetyltransferase WR47_20825 ENOG4105K7K Transcriptional regulator WR47_20830 ENOG4105DTD Dehydrogenase WR47_20850 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase WR47_20875 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) WR47_20890 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WR47_20900 ENOG4105BZU Histidine kinase WR47_20920 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) WR47_20935 ENOG4105CID antiterminator WR47_20945 ENOG4105FDP GntR family transcriptional regulator WR47_20955 ENOG4105CE4 GlcNAc 6-P deacetylase WR47_20995 ENOG4107ZE5 PPIases accelerate the folding of proteins WR47_21000 ENOG4105PTM secreted protein WR47_21005 ENOG4105J7I hydrolase WR47_21015 ENOG4105G6R Stage v sporulation protein ae WR47_21025 ENOG4105CZ3 stage V sporulation protein ad WR47_21030 ENOG41090VF Stage v sporulation protein ac WR47_21050 ENOG4105C8J )-transporter WR47_21055 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR47_21065 ENOG41082AN stage II sporulation protein WR47_21070 ENOG4105DZ1 carboxypeptidase WR47_21075 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family WR47_21080 ENOG4105DVE abc transporter atp-binding protein WR47_21110 ENOG4105D7N magnesium and cobalt transport protein CorA WR47_21135 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WR47_21145 ENOG4105I3K Ferric uptake regulator, Fur family WR47_21150 ENOG4105MZ9 stage II sporulation protein m WR47_21170 ENOG4105CPC Aldo Keto reductase WR47_21175 ENOG4105CV8 reductase WR47_21180 ENOG4105RHY Pfam:UPF0157 WR47_21200 ENOG4107SKW Inherit from COG: Alpha beta hydrolase WR47_21210 ENOG4105ETE Transcriptional regulator (LacI family WR47_21215 ENOG4108YM7 Gcn5-related n-acetyltransferase WR47_21235 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) WR47_21240 ENOG4108R6K riboflavin synthase, subunit alpha WR47_21265 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) WR47_21270 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) WR47_21285 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WR47_21295 ENOG4105DFD Na H antiporter WR47_21300 ENOG4105CGH 5'-nucleotidase WR47_21370 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) WR47_21385 ENOG4108IXY short-chain dehydrogenase reductase WR47_21390 ENOG41069FQ Metallo-beta-lactamase superfamily WR47_21395 ENOG4105II7 pyrroline-5-carboxylate reductase WR47_21400 ENOG4105EJQ L-serine dehydratase WR47_21435 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic WR47_21455 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) WR47_21460 ENOG4105D9U N-acetyltransferase WR47_21475 ENOG4108VZI ErfK ybiS ycfS ynhG family protein WR47_21480 ENOG4108QEG Membrane WR47_21485 ENOG4105CDA abc transporter atp-binding protein WR47_21490 ENOG4105E5Q amino acid AbC transporter WR47_21495 ENOG4108HW3 (ABC) transporter WR47_21510 ENOG4105G7B Protein of unknown function (DUF2992) WR47_21520 ENOG4108QY0 Membrane WR47_21535 ENOG4105C7S Dehydrogenase WR47_21540 ENOG4105CPP Dehydrogenase, E1 component WR47_21555 ENOG4105CKM Branched-chain carboxylic acid kinase WR47_21560 ENOG4107RDP Dehydrogenase WR47_21575 ENOG4108JUB Transcriptional regulator WR47_21585 ENOG4108QXE glycerophosphoryl diester phosphodiesterase WR47_21600 ENOG4107QQR Sporulation WR47_21610 ENOG4105S1Z Stage IV sporulation protein B WR47_21615 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) WR47_21620 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) WR47_21625 ENOG4105DX0 Hemolysin A WR47_21635 ENOG4105CTB Polyprenyl synthetase WR47_21650 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) WR47_21660 ENOG4108ZSR alkaline shock protein WR47_21665 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase WR47_21690 ENOG410644B Stage III sporulation protein af WR47_21700 ENOG4105KQ4 Stage iii sporulation protein ad WR47_21705 ENOG4108CQH stage III sporulation protein AC WR47_21710 ENOG4105KR5 Stage iii sporulation protein WR47_21715 ENOG4105CD2 stage iii sporulation protein aa WR47_21740 ENOG4105DC7 peptidase M24 WR47_21745 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) WR47_21755 ENOG4105CBJ Metal-dependent enzyme WR47_21765 ENOG4107YBY Hydrolase WR47_21795 ENOG41082GG biotin lipoate A B protein ligase WR47_21800 ENOG4105WZW rhodanese family WR47_21825 ENOG41080TC multidrug resistance protein WR47_21865 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family WR47_21895 ENOG4105C0D helicase WR47_21980 ENOG4107R6U sodium dicarboxylate symporter WR47_22020 ENOG4105D7V transposase WR47_22025 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) WR47_22030 ENOG4105C3R Methionine synthase WR47_22040 ENOG4105C28 cystathionine WR47_22045 ENOG4105C28 cystathionine WR47_22065 ENOG4105C5X domain protein WR47_22075 ENOG4105DKQ ROK family WR47_22085 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase WR47_22100 ENOG4108UTW Plays a role in the regulation of phosphate uptake WR47_22105 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) WR47_22110 ENOG4105C8U phosphate abc transporter WR47_22115 ENOG4105C8U phosphate abc transporter WR47_22120 ENOG4105EXS phosphate abc transporter WR47_22125 ENOG4107RF6 penicillin-binding protein WR47_22135 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WR47_22160 ENOG4105N80 Ferric uptake regulator, Fur family WR47_22170 ENOG4105FDK ABC transporter WR47_22175 ENOG4108JYZ YitT family WR47_22180 ENOG41069ZM Protein of unknown function (DUF2624) WR47_22205 ENOG4105EGD dinuclear metal center protein, YbgI family WR47_22220 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR47_22225 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) WR47_22255 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) WR47_22260 ENOG4105KG3 cytidine deaminase WR47_22265 ENOG4107YR5 Diacylglycerol kinase WR47_22270 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) WR47_22275 ENOG4105CTJ Metal Dependent Phosphohydrolase WR47_22280 ENOG4105C9A Phoh family WR47_22290 ENOG41068P3 sporulation protein YqfC WR47_22300 ENOG4105KTH gatB Yqey WR47_22310 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) WR47_22315 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) WR47_22345 ENOG4105CSA Coproporphyrinogen iii oxidase WR47_22350 ENOG4105KVH Transcriptional regulator WR47_22375 ENOG4105TQK DNA polymerase iii, delta' subunit WR47_22385 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 WR47_22390 ENOG4108UK2 deaminase WR47_22395 ENOG4105KQC Competence protein WR47_22405 ENOG4105DXX methyltransferase WR47_22415 ENOG4108WF2 Metal Dependent Phosphohydrolase WR47_22425 ENOG410812S Rna-binding protein WR47_22435 ENOG4105CQW ribosome biogenesis GTPase YqeH WR47_22440 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase WR47_22455 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR47_22475 ENOG4108TVJ Nitroreductase WR47_22490 ENOG4105G6Z alkaline phosphatase WR47_22495 ENOG4105KEG ribosomal-protein-alanine acetyltransferase WR47_22500 ENOG4108MUZ hydrolase WR47_22540 ENOG4105MIR Phenylalanine 4-monooxygenase WR47_22550 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase WR47_22590 ENOG4105S6R Iron-hydroxamate transporter permease subunit WR47_22595 ENOG4108V5C ABC transporter WR47_22605 ENOG4108EKI Dehydrogenase WR47_22610 ENOG4105C28 cystathionine WR47_22640 ENOG4107XRG penicillin-binding protein WR47_22645 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) WR47_22655 ENOG4105CFP Peptidase U32 WR47_22660 ENOG4105XYU peptidase (U32 family) WR47_22665 ENOG4108VQJ O-methyltransferase WR47_22670 ENOG4105HHA aminodeoxychorismate lyase WR47_22690 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WR47_22700 ENOG4105C02 permease WR47_22715 ENOG41060CR WR47_22720 ENOG4105C7H Helicase, RecD TraA family WR47_22730 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) WR47_22735 ENOG4105C3J Cysteine desulfurase WR47_22745 ENOG4105D1H recombination factor protein RarA WR47_22750 ENOG4108VCI transcription factor, rsfa family WR47_22760 ENOG4105CUZ uba thif-type nad fad binding protein WR47_22770 ENOG4105CUT histidyl-tRNA synthetase WR47_22780 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) WR47_22785 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) WR47_22795 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) WR47_22800 ENOG41076HS cation diffusion facilitator family transporter WR47_22805 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WR47_22815 ENOG4105CKP Polysaccharide Biosynthesis Protein WR47_22820 ENOG4108QG2 Membrane WR47_22830 ENOG4105VIE preprotein translocase, subunit YajC WR47_22845 ENOG41061AI Protein of unknown function (DUF2905) WR47_22860 ENOG4108HUF Transporter WR47_22890 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase WR47_22910 ENOG4108RPX mosc domain containing protein WR47_22915 ENOG4105CQC Prephenate dehydratase WR47_22930 ENOG4105C19 ABC transporter WR47_22935 ENOG4105EWM Histidine kinase WR47_22945 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control WR47_22960 ENOG4105X36 (ribosomal) protein WR47_22970 ENOG4105C03 ribonuclease WR47_22985 ENOG4107QMS site-determining protein WR47_23000 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) WR47_23005 ENOG4105DFF Rod shape-determining protein mreb WR47_23025 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase WR47_23030 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) WR47_23040 ENOG41068KH stage VI sporulation protein D WR47_23050 ENOG4105D52 delta-aminolevulinic acid dehydratase WR47_23075 ENOG4105K56 Transcriptional regulator WR47_23095 ENOG4108IUQ atp-dependent protease WR47_23125 ENOG4108QCI YvbH-like oligomerisation region WR47_23145 ENOG4105M59 Phosphodiesterase, mj0936 family WR47_23160 ENOG4108XJQ germination protein WR47_23170 ENOG4108PCX Major Facilitator WR47_23180 ENOG4105KBX Transcriptional regulator, TetR family WR47_23190 ENOG4105PFC Transcriptional regulator WR47_23200 ENOG4105DZC cytosine deaminase WR47_23205 ENOG41067S9 phage shock protein C, PspC WR47_23210 ENOG4108JCI Transcriptional regulator WR47_23220 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) WR47_23225 ENOG4108Z40 Transcriptional regulator WR47_23230 ENOG4105RHA ABC transporter, permease WR47_23235 ENOG4108IUX (ABC) transporter WR47_23240 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family WR47_23245 ENOG4105ER2 Ompa motb domain protein WR47_23250 ENOG4105E14 MotA TolQ exbB proton channel WR47_23255 ENOG4108VXD carboxy-peptidase WR47_23265 ENOG4105E33 succinate dehydrogenase WR47_23275 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit WR47_23285 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) WR47_23290 ENOG4105K63 Thioredoxin WR47_23295 ENOG4105C10 Electron transfer flavoprotein WR47_23300 ENOG4105BZJ Electron transfer flavoprotein WR47_23305 ENOG41060WC Enoyl-CoA hydratase WR47_23310 ENOG4107Z3H Transcriptional regulator, TetR family WR47_23315 ENOG4105CEY Amp-dependent synthetase and ligase WR47_23325 ENOG4105J76 Periplasmic binding protein WR47_23330 ENOG4105S6R Iron-hydroxamate transporter permease subunit WR47_23380 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR47_23395 ENOG4105DR4 Methyltransferase WR47_23405 ENOG4105KFN sortase, SrtB family WR47_23410 ENOG4105E0A ABC, transporter WR47_23425 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) WR47_23435 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) WR47_23445 ENOG4105FE9 pseudouridine synthase WR47_23460 ENOG4105DCG PHP domain protein WR47_23475 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) WR47_23495 ENOG4105C5S asparaginyl-tRNA synthetase WR47_23500 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) WR47_23510 ENOG4108RWN rrna methyltransferase WR47_23540 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR47_23545 ENOG4105CW7 secretion protein, HlyD family WR47_23550 ENOG4108JGH Tetr family transcriptional regulator WR47_23555 ENOG4105CN9 Peptidase m42 family protein WR47_23575 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) WR47_23580 ENOG4105C22 threonyL-tRNA synthetase WR47_23585 ENOG4108TDW sporulation protein YtxC WR47_23610 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) WR47_23615 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase WR47_23620 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) WR47_23630 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) WR47_23635 ENOG4105C2M dna polymerase I WR47_23640 ENOG4105BZU Histidine kinase WR47_23645 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR47_23665 ENOG4108HMX isocitrate dehydrogenase (NADP) WR47_23670 ENOG4105BZN citrate synthase WR47_23685 ENOG4108REF Sporulation integral membrane protein ytvi WR47_23690 ENOG4105FS0 cytoplasmic membrane protein WR47_23715 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family WR47_23720 ENOG4105C6K Malic enzyme WR47_23725 ENOG4105C0B DNA polymerase III (alpha subunit) WR47_23730 ENOG4105VV2 WR47_23740 ENOG4105SFS phosphoesterase RecJ domain protein WR47_23770 ENOG4105DC7 peptidase M24 WR47_23805 ENOG4105Z7P Acetyltransferase (GNAT) family WR47_23810 ENOG41082W1 Cupin 2, conserved barrel domain protein WR47_23830 ENOG4107YZX Universal stress protein WR47_23870 ENOG4108JYZ YitT family WR47_23890 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) WR47_23900 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) WR47_23905 ENOG4105KBJ sporulation protein ytfj WR47_23920 ENOG4105EFZ amidohydrolase WR47_23930 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WR47_23965 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) WR47_23990 ENOG4108KB2 LysR family Transcriptional regulator WR47_24000 ENOG4105U5Y Transcriptional regulator WR47_24010 ENOG4105C28 cystathionine WR47_24040 ENOG4105EMN RNA polymerase sigma factor WR47_24050 ENOG4108UW5 maltose o-acetyltransferase WR47_24060 ENOG4105F1V Acetoin utilization protein WR47_24065 ENOG4105W87 Cbs domain WR47_24070 ENOG4105DGU Histone deacetylase WR47_24075 ENOG4106HB6 Alpha beta hydrolase WR47_24085 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR47_24090 ENOG4105BZU Histidine kinase WR47_24095 ENOG4107SNB ankyrin repeat protein YahD WR47_24100 ENOG4105EP9 oxidoreductase WR47_24125 ENOG4105ETE Transcriptional regulator (LacI family WR47_24135 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase WR47_24140 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase WR47_24160 ENOG4105C88 aminopeptidase WR47_24185 ENOG4108IPJ Membrane WR47_24220 ENOG4108VDD TRNA binding domain protein WR47_24250 ENOG4105C8F Beta-lactamase domain protein WR47_24265 ENOG4108V15 phosphotransferase enzyme family WR47_24270 ENOG4108IUM Glycogen debranching enzyme WR47_24285 ENOG4107QSE Dipeptidase WR47_24290 ENOG4105YW5 deoR family transcriptional regulator WR47_24305 ENOG4105CBX hi0933 family WR47_24340 ENOG4108VJ1 Transcriptional regulator (CarD family WR47_24345 ENOG4107EXU Short-chain dehydrogenase reductase Sdr WR47_24350 ENOG4105CSC Glucose uptake protein WR47_24365 ENOG4108ZAF Molybdopterin WR47_24370 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein WR47_24375 ENOG4105CVM Molybdenum cofactor synthesis domain protein WR47_24385 ENOG4105D06 uba thif-type nad fad binding protein WR47_24390 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WR47_24410 ENOG41085GJ domain protein WR47_24420 ENOG4105DWV Homoserine O-trans-acetylase WR47_24455 ENOG4105C8T Leucyl-tRNA synthetase WR47_24460 ENOG410605W Major Facilitator WR47_24465 ENOG4107S91 Sodium hydrogen exchanger WR47_24470 ENOG4105NCW Trka-c domain protein WR47_24485 ENOG4105C19 ABC transporter WR47_24505 ENOG4105N5T Radical SAM Protein WR47_24515 ENOG4105CIG ABC transporter WR47_24545 ENOG4105E8V Alpha Beta Hydrolase Fold protein WR47_24550 ENOG4108Z0R Transferase WR47_24555 ENOG4105YVM Phosphoesterase, PA-phosphatase related WR47_24560 ENOG4105BZF Glycosyl transferase (Group 1 WR47_24570 ENOG4105EPU Molybdenum cofactor synthesis domain protein WR47_24650 ENOG4105BZU Histidine kinase WR47_24655 ENOG4105BZU Histidine kinase WR47_24660 ENOG4105CH6 catalase WR47_24665 ENOG4107S9D Alpha beta hydrolase WR47_24670 ENOG4107T7U Sulfatase WR47_24690 ENOG4105D2X ABC transporter substrate-binding protein WR47_24700 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component WR47_24715 ENOG4107XGZ Hydrolase WR47_24765 ENOG4108V2W Carbonate dehydratase WR47_24770 ENOG4105C4M (Ubiquinol oxidase) subunit I WR47_24775 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii WR47_24810 ENOG41087YS Phage shock protein A WR47_24835 ENOG4105N67 Proton-coupled thiamine transporter YuaJ WR47_24840 ENOG4105BZU Histidine kinase WR47_24845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR47_24870 ENOG4108UGV hypoxanthine phosphoribosyltransferase WR47_24875 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) WR47_24905 ENOG4107ZTW SNARE associated Golgi WR47_24920 ENOG4105C19 ABC transporter WR47_24925 ENOG41086D8 Transcriptional regulator WR47_24940 ENOG41082BM Transcriptional regulator, arsr family WR47_24990 ENOG4105C6Z Gluconate WR47_24995 ENOG4105FDP GntR family transcriptional regulator WR47_25015 ENOG41069H0 dihydroorotase EC 3.5.2.3 WR47_25035 ENOG4105DTQ mandelate racemase muconate lactonizing WR47_25040 ENOG4105CEY Amp-dependent synthetase and ligase WR47_25045 ENOG4108IPT Naphthoate synthase WR47_25050 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) WR47_25055 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) WR47_25060 ENOG4105E4F Isochorismate synthase WR47_25065 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase WR47_25075 ENOG4105VEQ Cold shock protein WR47_25120 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) WR47_25125 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) WR47_25135 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin WR47_25270 ENOG4105KT7 mgtC SapB transporter WR47_25275 ENOG4107PBV potassium channel WR47_25295 ENOG4105WG9 Conserved Protein WR47_25305 ENOG4105CHM Aminotransferase WR47_25310 ENOG4108ZB6 transcriptional regulator AsnC family WR47_25315 ENOG4105C5I Dehydrogenase WR47_25320 ENOG4108MUZ hydrolase WR47_25330 ENOG4105C87 Aminotransferase class I and II WR47_25345 ENOG4105Y38 Kinase-associated protein B WR47_25355 ENOG4107R3E Citrate transporter WR47_25370 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) WR47_25375 ENOG4105KA0 thioesterase Superfamily protein WR47_25395 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase WR47_25420 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) WR47_25425 ENOG4106YN8 Prenyltransferase WR47_25435 ENOG41069ER domain protein WR47_25450 ENOG4105CEP NADH dehydrogenase WR47_25475 ENOG4105EWC Purine nucleoside phosphorylase WR47_25485 ENOG4108VQJ O-methyltransferase WR47_25500 ENOG4108YX9 iron--sulfur cluster insertion protein erpA WR47_25525 ENOG4108JJA ABC, transporter WR47_25530 ENOG4105C4B ABC transporter, permease WR47_25535 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA WR47_25565 ENOG41083MR nifu domain-containing protein WR47_25580 ENOG4108W5N phosphatidylglycerophosphatase a WR47_25600 ENOG4105DAX Pfam:DUF2983 WR47_25610 ENOG4105DYS nad(p)h dehydrogenase (quinone) WR47_25615 ENOG4105D4U had-superfamily hydrolase, subfamily iia WR47_25630 ENOG4105CBT Fructose-1,6-bisphosphatase WR47_25655 ENOG4105MMD transcriptional regulator WR47_25660 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) WR47_25665 ENOG4107TXC Transcriptional regulator WR47_25670 ENOG41090T1 Membrane WR47_25695 ENOG4105FAA peptidase M23 WR47_25700 ENOG4108YTE sporulation protein YunB WR47_25705 ENOG4105KZD Domain of unknown function (DUF1805) WR47_25710 ENOG4107R8B 5'-nucleotidase WR47_25715 ENOG4105DIW FeS assembly protein SUFB WR47_25720 ENOG4108UNV SUF system FeS assembly protein, NifU family WR47_25725 ENOG4105C9B Cysteine desulfurase WR47_25730 ENOG4105JRK feS assembly protein SufD WR47_25735 ENOG4105C3K feS assembly ATPase SufC WR47_25740 ENOG4105D01 (LipO)protein WR47_25745 ENOG4105D01 (LipO)protein WR47_25750 ENOG4108UMI ABC transporter, permease WR47_25755 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WR47_25780 ENOG41080E8 Transcriptional regulator, Spx MgsR family WR47_25815 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) WR47_25840 ENOG4108W8B Beta-lactamase domain protein WR47_25845 ENOG4105C1G acyl-Coa dehydrogenase WR47_25850 ENOG4105CHU acetyl-coa acetyltransferase WR47_25865 ENOG4105DZ1 carboxypeptidase WR47_25885 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer WR47_25900 ENOG4108SUT Major Facilitator Superfamily WR47_25905 ENOG4107R7I amino acid WR47_25920 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins WR47_25930 ENOG4107AYK membrAne WR47_25965 ENOG4107ZTW SNARE associated Golgi WR47_25975 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein WR47_25980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR47_25985 ENOG4105BZU Histidine kinase WR47_26015 ENOG4105C8Q Methyl-accepting chemotaxis WR47_26020 ENOG4105VG1 fes assembly suf system protein WR47_26025 ENOG4105D4Y metalloprotease WR47_26030 ENOG4105C2I pirin domain protein WR47_26045 ENOG4107T5V SNARE associated Golgi WR47_26050 ENOG4107S91 Sodium hydrogen exchanger WR47_26055 ENOG4105NCW Trka-c domain protein WR47_26070 ENOG4108RMU ferritin dps family protein WR47_26090 ENOG4108URH decarboxylase WR47_26100 ENOG41090A1 ferritin WR47_26110 ENOG4105D9N nucleoside WR47_26115 ENOG4105D9N nucleoside WR47_26130 ENOG4108RYK Nad-dependent epimerase dehydratase WR47_26145 ENOG4105CV8 reductase WR47_26150 ENOG4105F27 Major Facilitator WR47_26155 ENOG4105KVH Transcriptional regulator WR47_26170 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) WR47_26175 ENOG4105D4A Cell wall formation (By similarity) WR47_26195 ENOG4105WMR Protein CrcB homolog WR47_26200 ENOG4105WMR Protein CrcB homolog WR47_26215 ENOG4108MK9 spermidine N(1)-acetyltransferase WR47_26220 ENOG4108VY7 phosphate-starvation-inducible protein PsiE WR47_26230 ENOG4108W2Y isochorismatase WR47_26250 ENOG4108V2W Carbonate dehydratase WR47_26255 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) WR47_26275 ENOG4108IPW abc transporter atp-binding protein WR47_26280 ENOG4105CM4 permease protein WR47_26305 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) WR47_26315 ENOG4105XZU Preprotein translocase, subunit SecG WR47_26320 ENOG41067MG lrgb family WR47_26370 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR47_26380 ENOG4105RHA ABC transporter, permease WR47_26385 ENOG4108IUX (ABC) transporter WR47_26390 ENOG4105BZU Histidine kinase WR47_26395 ENOG4108W5X Transcriptional Regulator, LuxR family WR47_26450 ENOG41090VF Stage v sporulation protein ac WR47_26455 ENOG4105CZ3 stage V sporulation protein ad WR47_26470 ENOG4108QY0 Membrane WR47_26475 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) WR47_26480 ENOG4105KRI phosphocarrier protein (HPr WR47_26490 ENOG4105CHW UPF0052 protein WR47_26495 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) WR47_26500 ENOG4108Z4K mutator MutT protein WR47_26510 ENOG4105C3M thioredoxin reductase WR47_26520 ENOG4108S4C acetyltransferase WR47_26540 ENOG41086DT Membrane protein of unknown function WR47_26545 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) WR47_26565 ENOG4107TXC Transcriptional regulator WR47_26585 ENOG4105DUM transcriptional regulator, lysR family WR47_26595 ENOG4108WS4 fmn reductase WR47_26600 ENOG4105C5H ABC transporter WR47_26610 ENOG4105BZ1 (ABC) transporter WR47_26620 ENOG4105CN1 protease WR47_26625 ENOG4105CRP Part of the ABC transporter FtsEX involved in WR47_26630 ENOG4105CAK Cell division ATP-binding protein ftsE WR47_26645 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) WR47_26660 ENOG4108RDQ ABC transporter WR47_26690 ENOG4105MS2 ribosomal subunit Interface protein WR47_26695 ENOG4105VEQ Cold shock protein WR47_26700 ENOG41081UC Inherit from COG: Competence protein WR47_26715 ENOG4105KVH Transcriptional regulator WR47_26725 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein WR47_26730 ENOG4108KGH TRANSCRIPTIONal WR47_26735 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase WR47_26740 ENOG4105C6Y Udp-glucose 6-dehydrogenase WR47_26745 ENOG4105ESV Glycosyl transferase, family 4 WR47_26755 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WR47_26775 ENOG4105F8D glycoside hydrolase family 4 WR47_26780 ENOG4105VCP PTS System WR47_26785 ENOG4105CK1 PTS System WR47_26795 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) WR47_26800 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) WR47_26805 ENOG4105VCP PTS System WR47_26815 ENOG4105VZJ PTS System WR47_26835 ENOG4105ECB domain protein WR47_26840 ENOG4107RSM transcriptional regulator WR47_26875 ENOG4105DAA L-lactate WR47_26885 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) WR47_26895 ENOG4105E0M Sulfatase WR47_26920 ENOG4107R8N Glycosyl transferase, family 2 WR47_26930 ENOG4105C94 Transporter WR47_26935 ENOG41069ER domain protein WR47_26960 ENOG4105KBK Zinc finger, swim domain protein WR47_26965 ENOG4105C0D helicase WR47_26995 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR47_27005 ENOG4107RBB ABC transporter, permease WR47_27010 ENOG4105C19 ABC transporter WR47_27020 ENOG4105CXY transporter WR47_27035 ENOG4105BZU Histidine kinase WR47_27040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR47_27045 ENOG4105CMR udp-glucose 4-epimerase WR47_27050 ENOG4105CMR udp-glucose 4-epimerase WR47_27060 ENOG4108KGH TRANSCRIPTIONal WR47_27070 ENOG4105C6Y Udp-glucose 6-dehydrogenase WR47_27085 ENOG4107T8Q Glycosyl transferase (Group 1 WR47_27090 ENOG4105K64 Glycosyl transferase, family 2 WR47_27095 ENOG4108PQP glycosyl transferase group 1 WR47_27110 ENOG4105D3Q Sugar transferase WR47_27115 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase WR47_27125 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase WR47_27130 ENOG4108RB3 Capsular polysaccharide biosynthesis protein WR47_27135 ENOG4107YJ4 chain length determinant protein WR47_27140 ENOG4105HTX biosynthesis protein WR47_27145 ENOG4107YJ4 chain length determinant protein WR47_27160 ENOG4105MT0 Sporulation transcriptional regulator spoiiid WR47_27170 ENOG4105FRN stage II sporulation protein WR47_27185 ENOG4105DY9 regulatoR WR47_27205 ENOG4106778 Protein of unknown function (DUF1146) WR47_27210 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WR47_27215 ENOG4105C8S subunit m WR47_27220 ENOG4105D65 subunit l WR47_27245 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WR47_27250 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain WR47_27260 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain WR47_27265 ENOG4105BZU Histidine kinase WR47_27315 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) WR47_27320 ENOG41062M3 atp synthase WR47_27340 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) WR47_27345 ENOG4108UIC UPF0340 protein WR47_27350 ENOG4108YZG isomerase WR47_27365 ENOG4108VGI doxx family WR47_27370 ENOG4107XC4 flavin reductase domain protein, FMN-binding WR47_27390 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WR47_27400 ENOG4108ZXQ stage ii sporulation protein r WR47_27405 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) WR47_27410 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) WR47_27425 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) WR47_27430 ENOG4105CBT Fructose-1,6-bisphosphatase WR47_27435 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) WR47_27455 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) WR47_27470 ENOG4105C1G acyl-Coa dehydrogenase WR47_27475 ENOG4105C1G acyl-Coa dehydrogenase WR47_27480 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WR47_27490 ENOG4105DF6 Fe-S oxidoreductase WR47_27505 ENOG4105BZU Histidine kinase WR47_27520 ENOG4105D4Y metalloprotease WR47_27530 ENOG4105BZU Histidine kinase WR47_27535 ENOG4105KCT ABC transporter WR47_27540 ENOG4108M15 ABC transporter WR47_27545 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) WR47_27555 ENOG4105IIU Aminopeptidase WR47_27575 ENOG4105EMN RNA polymerase sigma factor WR47_27585 ENOG410684U Domain of unknown function (DUF1934) WR47_27610 ENOG4105CYW agmatinase WR47_27620 ENOG4105DXB Major Facilitator superfamily WR47_27625 ENOG4107SWG transcriptional regulator MERR family WR47_27630 ENOG4108QXE glycerophosphoryl diester phosphodiesterase WR47_27635 ENOG4105BZ4 penicillin-binding protein WR47_27640 ENOG4108XFG YwhD family WR47_27645 ENOG4108Z4T Peptidase M50 WR47_27650 ENOG41069HH 4-oxalocrotonate tautomerase WR47_27655 ENOG4105DCI Phosphohydrolase WR47_27660 ENOG4108MES Periplasmic binding protein WR47_27665 ENOG4105E0A ABC, transporter WR47_27670 ENOG4105EHG Permease protein WR47_27675 ENOG4105DQ5 transport system permease protein WR47_27685 ENOG4108VCI transcription factor, rsfa family WR47_27690 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) WR47_27695 ENOG4108IJ2 phosphate acetyltransferase WR47_27700 ENOG4107UEZ chlorite dismutase WR47_27710 ENOG4108VKI Cell wall hydrolase WR47_27730 ENOG4107SVH Potassium channel protein WR47_27740 ENOG410667J hydrolase WR47_27745 ENOG4105VCH membrane WR47_27755 ENOG4108TU7 Inherit from COG: (ABC) transporter WR47_27760 ENOG4105CJ1 ABC, transporter WR47_27765 ENOG41090WU lipolytic protein G-D-S-L family WR47_27780 ENOG4105D6E homoserine dehydrogenase WR47_27785 ENOG4105CVG Homoserine O-transsuccinylase WR47_27805 ENOG4108Y4K DNA-binding transcriptional activator WR47_27815 ENOG4105WH1 Two component transcriptional regulator luxr family WR47_27820 ENOG4105BZU Histidine kinase WR47_27825 ENOG4105DWF phosphomethylpyrimidine kinase WR47_27830 ENOG4105BZU Histidine kinase WR47_27835 ENOG4105VCD cytoplasmic protein WR47_27840 ENOG4105D22 carbon starvation protein WR47_27845 ENOG4105DY9 regulatoR WR47_27850 ENOG41079KZ Major Facilitator Superfamily WR47_27860 ENOG4105CG5 Glycosyl transferase (Group 1 WR47_27870 ENOG4105EN6 Membrane WR47_27875 ENOG4106YBV Methyl-accepting chemotaxis WR47_27885 ENOG4108S4H thioesterase Superfamily protein WR47_27890 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) WR47_27900 ENOG4105K64 Glycosyl transferase, family 2 WR47_27910 ENOG4105EJV Membrane WR47_27915 ENOG4105CKK Glycosyl transferase, family 2 WR47_27925 ENOG4108IG5 Transcriptional regulator WR47_27930 ENOG4105C5H ABC transporter WR47_27935 ENOG41067SE Tetr family transcriptional regulator WR47_27945 ENOG4105E0X reductase WR47_27950 ENOG4106F5Q Membrane WR47_27965 ENOG4108NEV two component transcriptional regulator, LytTR family WR47_27970 ENOG4108HRK Histidine kinase WR47_27975 ENOG4107RGD Major Facilitator superfamily WR47_27990 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WR47_28000 ENOG4105IW1 AmiS UreI transporter WR47_28010 ENOG4105CMR udp-glucose 4-epimerase WR47_28015 ENOG4108UT2 hemolysin iii WR47_28025 ENOG4105C1J atp-dependent rna helicase WR47_28030 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) WR47_28035 ENOG4105DPN Oligoendopeptidase f WR47_28045 ENOG4105BZU Histidine kinase WR47_28060 ENOG4105C0H protease WR47_28065 ENOG4105Q2H domain protein WR47_28080 ENOG4105BZU Histidine kinase WR47_28085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR47_28110 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis WR47_28115 ENOG4105CDU Replicative dna helicase WR47_28125 ENOG4105BZR domain protein WR47_28130 ENOG4108XMW Membrane WR47_28140 ENOG4108UUM single-stranded DNA-binding protein WR47_28150 ENOG4105C3G gtp-binding protein WR47_28155 ENOG4105VDK protein, conserved in bacteria WR47_28160 ENOG4105D8X mechanosensitive ion channel WR47_28165 ENOG4108ZDA Sporulation protein YyaC WR47_28170 ENOG4105FA0 parb-like partition protein WR47_28175 ENOG4107QJE Chromosome Partitioning Protein WR47_28190 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) WR47_28195 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) WR47_28205 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins WR47_28245 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin WR47_28250 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin WR47_28305 ENOG4108IBT Inherit from COG: transposase WR47_28365 ENOG4105FQP Beta-lactamase WR47_28385 ENOG4105CHR reductase WR47_28390 ENOG4108594 Permease of the drug metabolite transporter WR47_28395 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR47_28405 ENOG4105DUX Transporter WR47_28420 ENOG4108IAJ Nad-dependent epimerase dehydratase WR47_28425 ENOG4107SBE Glycosyl transferase (Group 1 WR47_28445 ENOG4107SBE Glycosyl transferase (Group 1 WR47_28450 ENOG4108KS4 Spore coat protein WR47_28455 ENOG4105KRN Transcriptional regulator, abrb family WR47_28465 ENOG4105K70 DNA-binding protein WR47_28480 ENOG4105CIF Ornithine Cyclodeaminase WR47_28520 ENOG4105CUJ penicillin amidase WR47_28525 ENOG4105E5W Transporter WR47_28535 ENOG4108UZ3 Transporter WR47_28540 ENOG4105DRR Transcriptional regulator, GntR family WR47_28545 ENOG4108UZ3 Transporter WR47_28550 ENOG4105D7V transposase WR47_28575 ENOG4105KRN Transcriptional regulator, abrb family WR47_28580 ENOG4105K70 DNA-binding protein WR47_28615 ENOG4105DQ6 Transposase WR47_28655 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WR47_28720 ENOG4108M0I Transcriptional regulator WR47_28765 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C WR47_28775 ENOG4105DHF Membrane WR47_28885 ENOG41068WN WR47_28905 ENOG4105E5W Transporter WR47_29040 ENOG4108SHJ s-layer protein WR47_29100 ENOG4105EKQ RNA-directed DNA polymerase WR47_29265 ENOG4105YWU small acid-soluble spore protein WR47_29275 ENOG4107JM4 Tetratricopeptide repeat WR47_29310 ENOG4105M6F mutator MutT protein WR47_29315 ENOG4108WZA zeta toxin WR47_29350 ENOG4107R0E Glycosyl transferase, family 2 WR47_29390 ENOG4105IIU Aminopeptidase WR47_29425 ENOG41065S2 pneumococcal vaccine antigen WR47_29430 ENOG4105DR5 peptidase WR47_29435 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase WR47_29450 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR47_29525 ENOG4108JJA ABC, transporter WR47_29550 ENOG4108IMY Transcriptional regulator WR47_29560 ENOG4107VMI polysaccharide deacetylase WR47_29575 ENOG4105D7V transposase WR47_29580 ENOG4108RZE Tetr family transcriptional regulator WR47_29585 ENOG4105CAQ asparagine synthetase WR47_29625 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR47_29655 ENOG4105K70 DNA-binding protein WR47_29670 ENOG410645S MarR family Transcriptional regulator WR47_29690 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WR47_29725 ENOG4105C4R Atp-dependent dna helicase WR47_29785 ENOG4107UNZ domain protein WR47_29795 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) WR47_29800 ENOG4105C4R Atp-dependent dna helicase WR47_29860 ENOG4107SET aldo keto reductase WR47_29885 ENOG4105C0W non-ribosomal peptide synthetase WR47_29885 ENOG4105C0W non-ribosomal peptide synthetase WR47_29905 ENOG4105C1G acyl-Coa dehydrogenase WR47_29920 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WR47_29925 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) WR47_29940 ENOG4105C0W non-ribosomal peptide synthetase WR47_29945 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) WR47_29950 ENOG4105IBP Cyclic peptide transporter WR47_29990 ENOG4105TRI Hydrolase WR47_30020 ENOG41067FT ParB-like nuclease domain WR47_30080 ENOG4105D4Y metalloprotease WR47_30175 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) WR47_30215 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) WR47_30225 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) WR47_30230 ENOG4105D7V transposase WR47_30280 ENOG4105C5E polysaccharide biosynthesis protein WR47_30285 ENOG4105C1B dTDP-glucose 4-6-dehydratase WR47_30290 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase WR47_30295 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) WR47_30315 ENOG4105D7V transposase WR47_30355 ENOG4107Y80 Major Facilitator superfamily WR47_30380 ENOG4105CEY Amp-dependent synthetase and ligase WR47_30430 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin WR47_30435 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases WR47_30440 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) WR47_30505 ENOG4105CJW magnesium transporter WR47_30510 ENOG4105CNI cell division protein FtsW WR47_30515 ENOG4105FQP Beta-lactamase WR47_30520 ENOG4107SCK Monooxygenase WR47_30540 ENOG41067SE Tetr family transcriptional regulator WR47_30560 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer WR47_30575 ENOG4105C44 Serine transporter WR47_30580 ENOG4105EJQ L-serine dehydratase WR47_30590 ENOG4105EQ0 Major Facilitator superfamily WR47_30595 ENOG4108JGH Tetr family transcriptional regulator