locus-tag class description HPG46_00085 ENOG4108Z0C Uvrb UvrC protein HPG46_00100 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HPG46_00110 ENOG4105CTP PilT protein domain protein HPG46_00130 ENOG4105D7W serine acetyltransferase HPG46_00145 ENOG4105C2N RNA methyltransferase TrmH family group 3 HPG46_00150 ENOG4105M0M Tetracycline resistance protein HPG46_00155 ENOG4105QIV RNA polymerase HPG46_00170 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HPG46_00195 ENOG4107Y49 methyltransferase HPG46_00210 ENOG4105XPM ribosomal protein HPG46_00340 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HPG46_00350 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPG46_00395 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HPG46_00425 ENOG4105D1F ATP-binding protein HPG46_00440 ENOG4108NMV polysaccharide deacetylase HPG46_00520 ENOG4105C8B TIGR00159 family HPG46_00525 ENOG4107U5W ybbr family HPG46_00550 ENOG4108VQT Alpha beta hydrolase fold protein HPG46_00560 ENOG4105CMG Carbohydrate kinase HPG46_00570 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HPG46_00580 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HPG46_00600 ENOG4108PSK reductase HPG46_00605 ENOG4108UMI ABC transporter, permease HPG46_00610 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPG46_00615 ENOG4105D01 (LipO)protein HPG46_00630 ENOG4105IQ5 FAD linked oxidase domain protein HPG46_00645 ENOG4105C2C drug resistance transporter, Bcr CflA HPG46_00660 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPG46_00665 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPG46_00670 ENOG4105C3U ABC transporter HPG46_00675 ENOG4108JQ7 (ABC) transporter HPG46_00705 ENOG4108J59 Extracellular solute-binding protein, family 5 HPG46_00710 ENOG4108J59 Extracellular solute-binding protein, family 5 HPG46_00720 ENOG4105II7 pyrroline-5-carboxylate reductase HPG46_00725 ENOG4107XDY Nicotinamide Mononucleotide Transporter HPG46_00735 ENOG4105E0C molybdate abc transporter HPG46_00740 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HPG46_00745 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HPG46_00775 ENOG4105F6E Acyl-transferase HPG46_00795 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HPG46_00815 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HPG46_00835 ENOG4105C5H ABC transporter HPG46_00850 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HPG46_00860 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPG46_00865 ENOG4105C3U ABC transporter HPG46_00870 ENOG4108JQ7 (ABC) transporter HPG46_00875 ENOG410667J hydrolase HPG46_00905 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HPG46_00910 ENOG4105ERH Fumarylacetoacetate hydrolase HPG46_00920 ENOG4105CUB amino acid HPG46_00925 ENOG4108SC4 )-transporter HPG46_00930 ENOG4105CPF Cell wall formation (By similarity) HPG46_00935 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HPG46_00950 ENOG4107ZXI Rhomboid family HPG46_00960 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HPG46_00965 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPG46_00975 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HPG46_01075 ENOG4105K8N protein family UPF0079, ATPase HPG46_01080 ENOG41072GX Peptidase M22 Glycoprotease HPG46_01085 ENOG410801F ribosomal-protein-alanine acetyltransferase HPG46_01095 ENOG4105C5H ABC transporter HPG46_01110 ENOG4108TYN CAAX amino terminal protease family protein HPG46_01130 ENOG4105C7N Xanthine uracil vitamin C permease HPG46_01140 ENOG4105BZU Histidine kinase HPG46_01165 ENOG4107ZXU DSBA oxidoreductase HPG46_01195 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HPG46_01215 ENOG4108SHN Glycosyl transferase, family 2 HPG46_01260 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPG46_01280 ENOG4105SX7 Transporter HPG46_01305 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HPG46_01310 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HPG46_01315 ENOG4105C83 adenylosuccinate lyase HPG46_01325 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HPG46_01350 ENOG4108V3E phosphoribosylglycinamide formyltransferase HPG46_01360 ENOG4105C12 Phosphoribosylglycinamide synthetase HPG46_01385 ENOG4105C4R Atp-dependent dna helicase HPG46_01415 ENOG4108W2Y isochorismatase HPG46_01420 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPG46_01425 ENOG4108UMI ABC transporter, permease HPG46_01430 ENOG4105D01 (LipO)protein HPG46_01450 ENOG410834F Transcriptional regulator HPG46_01455 ENOG4107I77 yiaA/B two helix domain HPG46_01475 ENOG4105CBD Diacylglycerol kinase HPG46_01480 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HPG46_01485 ENOG4108JPW Aminotransferase HPG46_01495 ENOG4105C26 Dehydrogenase HPG46_01500 ENOG4105KPY Small multidrug resistance protein HPG46_01520 ENOG4105D9N nucleoside HPG46_01525 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HPG46_01535 ENOG4105BZU Histidine kinase HPG46_01540 ENOG4108W15 Protein of unknown function (DUF1456) HPG46_01555 ENOG4105DTQ mandelate racemase muconate lactonizing HPG46_01565 ENOG4105DFD Na H antiporter HPG46_01585 ENOG4105D3R alkyl hydroperoxide reductase HPG46_01605 ENOG4105EHG Permease protein HPG46_01610 ENOG4105DQ5 transport system permease protein HPG46_01615 ENOG4108V5C ABC transporter HPG46_01635 ENOG4106UIA HPG46_01640 ENOG4106UIA HPG46_01685 ENOG410756H nucleotidyltransferase HPG46_01690 ENOG4105D2S major facilitator superfamily HPG46_01705 ENOG4105E5Q amino acid AbC transporter HPG46_01710 ENOG4105EAB amino acid AbC transporter HPG46_01720 ENOG4105C8Q Methyl-accepting chemotaxis HPG46_01725 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPG46_01735 ENOG4105CI1 PTS System HPG46_01765 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPG46_01780 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HPG46_01800 ENOG4105C5H ABC transporter HPG46_01830 ENOG41062JF Transcriptional regulator HPG46_01850 ENOG4105DEU major facilitator superfamily HPG46_01880 ENOG4108N0M stress protein HPG46_01885 ENOG4106FN3 tellurium resistance protein HPG46_01890 ENOG4106FN3 tellurium resistance protein HPG46_01895 ENOG4107TS3 membrane protein, TerC HPG46_01900 ENOG4108TTB tellurium resistance protein HPG46_01920 ENOG4105KJF protein tyrosine phosphatase HPG46_01930 ENOG4107U9T Pfam:Ribonuclease_BN HPG46_01935 ENOG4105C59 p-type ATPase HPG46_01940 ENOG4108IPJ Membrane HPG46_01950 ENOG4105C3F Signal peptidase i HPG46_01960 ENOG4107ZTW SNARE associated Golgi HPG46_01975 ENOG410606W general stress protein HPG46_01980 ENOG4105UPD Calcium Proton HPG46_02015 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HPG46_02030 ENOG4108JUB Transcriptional regulator HPG46_02040 ENOG4108IQI permease HPG46_02080 ENOG4108A04 Beta-lactamase HPG46_02100 ENOG4105CKK Glycosyl transferase, family 2 HPG46_02105 ENOG4107QQG Dehydrogenase HPG46_02110 ENOG4105C3I Nad-dependent epimerase dehydratase HPG46_02130 ENOG4105F1A Pyruvate formate-lyase HPG46_02150 ENOG4105CI2 imidazolone-5-propionate hydrolase HPG46_02155 ENOG4105ECP epimerase HPG46_02185 ENOG41067AE Membrane-bound metal-dependent hydrolase HPG46_02190 ENOG4105CEN a g-specific adenine glycosylase HPG46_02195 ENOG4106BXE HPG46_02215 ENOG4105BZ1 (ABC) transporter HPG46_02220 ENOG4107NBY Membrane HPG46_02225 ENOG4105CBC glutamate synthase HPG46_02235 ENOG4108IUW ABC transporter HPG46_02255 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPG46_02260 ENOG4105G5W regulator Fur family HPG46_02375 ENOG4108JQC penicillin-binding protein 1A HPG46_02380 ENOG4107ZQN disulfide bond HPG46_02390 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HPG46_02400 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HPG46_02405 ENOG4105BZU Histidine kinase HPG46_02410 ENOG4105CYN Serine protein kinase HPG46_02430 ENOG4105C94 Transporter HPG46_02445 ENOG4105DZ6 Band 7 protein HPG46_02455 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HPG46_02460 ENOG4108V9W transcriptional regulatory protein HPG46_02465 ENOG4105D4T Citrate transporter HPG46_02485 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HPG46_02490 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPG46_02495 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HPG46_02500 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HPG46_02505 ENOG4105BZ7 extracellular solute-binding protein family 1 HPG46_02510 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HPG46_02515 ENOG4108STX response regulator HPG46_02520 ENOG4105US7 Histidine kinase HPG46_02545 ENOG4108MRH transcriptional regulatory protein HPG46_02555 ENOG4105C6K Malic enzyme HPG46_02565 ENOG4108UZ3 Transporter HPG46_02570 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPG46_02580 ENOG4105BZU Histidine kinase HPG46_02585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_02590 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HPG46_02595 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HPG46_02600 ENOG4108JB9 formate dehydrogenase HPG46_02620 ENOG4105CUB amino acid HPG46_02630 ENOG4105C59 p-type ATPase HPG46_02635 ENOG4105DAP Nicotinate phosphoribosyltransferase HPG46_02670 ENOG41073R8 VanW family HPG46_02675 ENOG4108KGH TRANSCRIPTIONal HPG46_02680 ENOG4105D9N nucleoside HPG46_02685 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HPG46_02690 ENOG4105C37 (CBS) domain HPG46_02695 ENOG4108IJ0 Aspartate ammonia-lyase HPG46_02700 ENOG4105DAA L-lactate HPG46_02715 ENOG4105DUX Transporter HPG46_02720 ENOG4108MES Periplasmic binding protein HPG46_02725 ENOG4105DQ5 transport system permease protein HPG46_02730 ENOG4108IHU transport system permease protein HPG46_02735 ENOG4105E0A ABC, transporter HPG46_02740 ENOG4105DMQ Methyltransferase HPG46_02750 ENOG4105EXW epimerase dehydratase HPG46_02755 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HPG46_02765 ENOG4107T89 von Willebrand factor, type A HPG46_02770 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HPG46_02775 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HPG46_02790 ENOG4105BZU Histidine kinase HPG46_02795 ENOG4105D5Q Arginine ornithine antiporter HPG46_02800 ENOG4107414 GntR family transcriptional regulator HPG46_02805 ENOG4105C5Y PTS System HPG46_02810 ENOG4105CG3 alpha amylase, catalytic region HPG46_02825 ENOG4105E1K spore germination protein HPG46_02835 ENOG4105CRN Aminoglycoside phosphotransferase HPG46_02840 ENOG4105BZG amino acid carrier protein HPG46_02845 ENOG4105CDA abc transporter atp-binding protein HPG46_02850 ENOG4105CT1 (ABC) transporter HPG46_02855 ENOG4105EAD ABC transporter HPG46_02860 ENOG4105DRP amino acid AbC transporter HPG46_02865 ENOG4108IQI permease HPG46_02890 ENOG4105D29 Helix-turn-helix type 11 domain protein HPG46_02895 ENOG4105NAE bifunctional deaminase-reductase domain protein HPG46_02900 ENOG4105BZU Histidine kinase HPG46_02905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_02915 ENOG4105CHH sulfate transporter HPG46_02920 ENOG41068KF Universal stress protein HPG46_02930 ENOG4105DEF Extracellular solute-binding protein, family 5 HPG46_02940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPG46_02945 ENOG4108JQ7 (ABC) transporter HPG46_02955 ENOG4105CXY transporter HPG46_02960 ENOG41067TZ transcriptional regulator, MarR family HPG46_02965 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG46_02970 ENOG4105ETE Transcriptional regulator (LacI family HPG46_02975 ENOG4108RVA ribokinase HPG46_02990 ENOG4105CNN ABC, transporter HPG46_02995 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HPG46_03055 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HPG46_03060 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPG46_03065 ENOG41069ER domain protein HPG46_03070 ENOG4105VZ8 Transcriptional regulator HPG46_03075 ENOG4107D63 HPG46_03085 ENOG4105DUX Transporter HPG46_03095 ENOG4105D01 (LipO)protein HPG46_03100 ENOG4105FDT acyl-CoA dehydrogenase HPG46_03105 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPG46_03110 ENOG4108UMI ABC transporter, permease HPG46_03125 ENOG4105C85 amino acid HPG46_03130 ENOG4105C7N Xanthine uracil vitamin C permease HPG46_03145 ENOG4105MA6 gCN5-related N-acetyltransferase HPG46_03170 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPG46_03175 ENOG4105E2S oxidase) subunit II HPG46_03180 ENOG4108IQI permease HPG46_03195 ENOG4106CAD Protein of unknown function (DUF3311) HPG46_03200 ENOG4105E1V na solute symporter HPG46_03215 ENOG4108NHD germination protein HPG46_03220 ENOG4105CE1 Ferrous iron transport protein b HPG46_03225 ENOG4105CE1 Ferrous iron transport protein b HPG46_03230 ENOG4105CE1 Ferrous iron transport protein b HPG46_03235 ENOG4105CVA phosphate HPG46_03240 ENOG4105C8U phosphate abc transporter HPG46_03245 ENOG4105E2Z phosphate ABC transporter (Permease HPG46_03375 ENOG41080XQ Signal transduction protein with cbs domains HPG46_03395 ENOG4105ETU transcriptional activator (TenA HPG46_03405 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HPG46_03415 ENOG4108VEU Thiamine monophosphate synthase HPG46_03420 ENOG41080HI glycine oxidase HPG46_03435 ENOG4105D06 uba thif-type nad fad binding protein HPG46_03440 ENOG4105DWF phosphomethylpyrimidine kinase HPG46_03490 ENOG4108INS Transcriptional regulator HPG46_03515 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPG46_03525 ENOG4105CNN ABC, transporter HPG46_03530 ENOG4105C2J ABC transporter HPG46_03540 ENOG4105C7N Xanthine uracil vitamin C permease HPG46_03550 ENOG4108PXI ErfK YbiS YcfS YnhG HPG46_03585 ENOG4108B31 Spore germination protein HPG46_03605 ENOG4107Y03 Nitroreductase HPG46_03610 ENOG4105ED1 spovr family HPG46_03615 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HPG46_03620 ENOG4105XTG Pfam:DUF156 HPG46_03625 ENOG4105VFE sira family HPG46_03630 ENOG4107TPS domain protein HPG46_03635 ENOG4105VFE sira family HPG46_03640 ENOG41085GJ domain protein HPG46_03650 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HPG46_03655 ENOG41087NI Sulfite exporter TauE/SafE HPG46_03665 ENOG4108KGH TRANSCRIPTIONal HPG46_03690 ENOG4105EMD TRANSCRIPTIONal HPG46_03695 ENOG4105VCP PTS System HPG46_03700 ENOG4105VZJ PTS System HPG46_03720 ENOG41069ER domain protein HPG46_03725 ENOG4107RBB ABC transporter, permease HPG46_03730 ENOG4105C19 ABC transporter HPG46_03760 ENOG4105WEF catalase HPG46_03795 ENOG4107T5V SNARE associated Golgi HPG46_03830 ENOG4105CUB amino acid HPG46_03835 ENOG4107RWR Sodium hydrogen exchanger HPG46_03845 ENOG4106KNT transcriptional regulator HPG46_03880 ENOG4108PCN EamA-like transporter family HPG46_03885 ENOG4108YXU transcriptional regulator AsnC family HPG46_03900 ENOG4105KPY Small multidrug resistance protein HPG46_03920 ENOG4105YA8 Transcriptional regulator HPG46_03925 ENOG4106A3M Cytochrome p-450 HPG46_03940 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HPG46_03945 ENOG4105E5W Transporter HPG46_03955 ENOG4107RKG DJ-1/PfpI family HPG46_03960 ENOG4105CH6 catalase HPG46_03970 ENOG4105D5Q Arginine ornithine antiporter HPG46_03975 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HPG46_03985 ENOG4105C26 Dehydrogenase HPG46_03990 ENOG4105BZ1 (ABC) transporter HPG46_03995 ENOG4105BZ1 (ABC) transporter HPG46_04005 ENOG4105DRP amino acid AbC transporter HPG46_04010 ENOG4105CDA abc transporter atp-binding protein HPG46_04025 ENOG410839P HPG46_04060 ENOG4107FQX Alpha-acetolactate decarboxylase HPG46_04075 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HPG46_04080 ENOG4105D4P Coproporphyrinogen iii oxidase HPG46_04085 ENOG4105CEY Amp-dependent synthetase and ligase HPG46_04095 ENOG4105CHH sulfate transporter HPG46_04140 ENOG4106AKK s-layer domain-containing protein HPG46_04150 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HPG46_04155 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HPG46_04170 ENOG4105CGU Enoyl-CoA hydratase HPG46_04195 ENOG4105DER m42 family HPG46_04215 ENOG4105CTU Proline racemase HPG46_04260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPG46_04270 ENOG4108JQ7 (ABC) transporter HPG46_04285 ENOG4105CSH Transporter HPG46_04295 ENOG4108MRH transcriptional regulatory protein HPG46_04360 ENOG4105CDU Replicative dna helicase HPG46_04400 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG46_04445 ENOG4107P5I polyketide synthase HPG46_04450 ENOG4108IG5 Transcriptional regulator HPG46_04465 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HPG46_04485 ENOG4105CMT Dihydroxyacetone kinase HPG46_04495 ENOG4105CMT Dihydroxyacetone kinase HPG46_04505 ENOG410847I Transcriptional regulator, BadM Rrf2 family HPG46_04550 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HPG46_04645 ENOG4105WN5 stage II sporulation protein HPG46_04655 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG46_04665 ENOG4108MJI response regulator HPG46_04670 ENOG4105BZU Histidine kinase HPG46_04675 ENOG4105BZU Histidine kinase HPG46_04730 ENOG4107VRP DNA repair exonuclease HPG46_04735 ENOG4106D4I domain protein HPG46_04790 ENOG4108MUZ hydrolase HPG46_04810 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HPG46_04825 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HPG46_04845 ENOG4105EMN RNA polymerase sigma factor HPG46_04870 ENOG4105C57 major facilitator superfamily HPG46_04875 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG46_04885 ENOG4105EEM helicase HPG46_04890 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HPG46_04915 ENOG4105K59 histidine triad (HIT) protein HPG46_04990 ENOG410905X membrane-flanked domain protein HPG46_04995 ENOG4105CKV Membrane HPG46_05035 ENOG410905X membrane-flanked domain protein HPG46_05040 ENOG4105CKV Membrane HPG46_05045 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HPG46_05050 ENOG4105BZ4 penicillin-binding protein HPG46_05065 ENOG4105C1Q protoporphyrinogen oxidase HPG46_05090 ENOG4105NA0 Transcriptional regulator HPG46_05105 ENOG4105ECB domain protein HPG46_05130 ENOG4105D29 Helix-turn-helix type 11 domain protein HPG46_05140 ENOG4106AXD HPG46_05145 ENOG4108RQ5 Beta-lactamase domain-containing protein HPG46_05150 ENOG4105DF9 Lipoate-protein, ligase HPG46_05160 ENOG4105CEY Amp-dependent synthetase and ligase HPG46_05180 ENOG4107RN3 metallophosphoesterase HPG46_05190 ENOG4107TVP HD domain protein HPG46_05200 ENOG4108AEY RNA polymerase sigma factor HPG46_05205 ENOG41086D8 Transcriptional regulator HPG46_05225 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPG46_05250 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HPG46_05255 ENOG4105C8Q Methyl-accepting chemotaxis HPG46_05280 ENOG4107QP3 malate synthase g HPG46_05310 ENOG4105XVF Competence transcription factor HPG46_05375 ENOG4105ERH Fumarylacetoacetate hydrolase HPG46_05400 ENOG4105CAQ asparagine synthetase HPG46_05405 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HPG46_05410 ENOG4105CH6 catalase HPG46_05415 ENOG4105BZU Histidine kinase HPG46_05435 ENOG4105QNR S1 RNA binding domain protein HPG46_05445 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HPG46_05455 ENOG4107AYK membrAne HPG46_05460 ENOG41073B9 HPG46_05470 ENOG4108KP7 hydrolase HPG46_05480 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPG46_05505 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HPG46_05510 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPG46_05525 ENOG4105C31 Tryptophanyl-tRNA synthetase HPG46_05540 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPG46_05545 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPG46_05555 ENOG4108JQ7 (ABC) transporter HPG46_05560 ENOG4105UQX Mate efflux family protein HPG46_05580 ENOG4108ZCF integral membrane protein HPG46_05590 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HPG46_05600 ENOG4105DPN Oligoendopeptidase f HPG46_05615 ENOG4108Z18 K06886 hemoglobin HPG46_05620 ENOG4105MIX Adenylate cyclase HPG46_05640 ENOG4105EMS pseudouridine synthase HPG46_05660 ENOG4105K64 Glycosyl transferase, family 2 HPG46_05680 ENOG4107TVC Glycosyl transferase, family 2 HPG46_05700 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HPG46_05705 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HPG46_05715 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HPG46_05790 ENOG4105CK7 Sodium proline symporter HPG46_05800 ENOG4105DDQ anthranilate synthase HPG46_05895 ENOG4105C7S Dehydrogenase HPG46_05905 ENOG4105VZ8 Transcriptional regulator HPG46_05960 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HPG46_05970 ENOG4105DZ1 carboxypeptidase HPG46_05975 ENOG4105VFR signal peptidase HPG46_06010 ENOG4105C26 Dehydrogenase HPG46_06020 ENOG4105F38 ABC transporter, permease HPG46_06025 ENOG4105D38 putrescine abc transporter HPG46_06030 ENOG4107RUE extracellular solute-binding protein family 1 HPG46_06040 ENOG4105EYF MMPL domain protein HPG46_06050 ENOG4108YBP pseudouridine synthase HPG46_06060 ENOG4105K4I Scp-like extracellular HPG46_06065 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPG46_06070 ENOG4105CQB FAD linked oxidase domain protein HPG46_06085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_06090 ENOG4105BZU Histidine kinase HPG46_06095 ENOG4105JXH GntR family transcriptional regulator HPG46_06115 ENOG4106A3R peptidase HPG46_06125 ENOG4108QTI )-transporter HPG46_06130 ENOG4107TS3 membrane protein, TerC HPG46_06135 ENOG4105CZN Potassium uptake protein HPG46_06140 ENOG410681C small acid-soluble spore protein HPG46_06145 ENOG4108Z7G MaoC domain protein dehydratase HPG46_06165 ENOG4105CHR reductase HPG46_06175 ENOG4105MWK D-amino acid dehydrogenase, small subunit HPG46_06195 ENOG4105C4Y ABC transporter HPG46_06200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPG46_06205 ENOG4107RCV ABC transporter, permease HPG46_06225 ENOG4105E98 transcriptional regulator DeoR family HPG46_06235 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HPG46_06245 ENOG4105PXI polysaccharide deacetylase HPG46_06255 ENOG4105BZU Histidine kinase HPG46_06260 ENOG41090MY MarR family Transcriptional regulator HPG46_06270 ENOG4106DF1 HPG46_06275 ENOG4105BZU Histidine kinase HPG46_06285 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HPG46_06290 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HPG46_06330 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HPG46_06350 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPG46_06355 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HPG46_06360 ENOG4105CZV ABC transporter HPG46_06370 ENOG4105CJ1 ABC, transporter HPG46_06410 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPG46_06415 ENOG4105EA8 2-Nitropropane dioxygenase HPG46_06420 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HPG46_06430 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HPG46_06455 ENOG4105NQC Flavodoxin HPG46_06495 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HPG46_06525 ENOG4105CZN Potassium uptake protein HPG46_06530 ENOG41063Y9 HPG46_06535 ENOG4105KBJ sporulation protein ytfj HPG46_06555 ENOG4105CM2 brancheD-chain amino acid aminotransferase HPG46_06560 ENOG4105C7K acetolactate synthase HPG46_06565 ENOG4108ZP8 Acetolactate synthase small subunit HPG46_06640 ENOG4107RVV histidinol phosphate phosphatase, hisj family HPG46_06655 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HPG46_06660 ENOG4105E0M Sulfatase HPG46_06670 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HPG46_06690 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HPG46_06695 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HPG46_06705 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HPG46_06710 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HPG46_06715 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HPG46_06720 ENOG4105C8J )-transporter HPG46_06740 ENOG4105DFD Na H antiporter HPG46_06760 ENOG4105ENE Histidine kinase HPG46_06765 ENOG4105WH1 Two component transcriptional regulator luxr family HPG46_06785 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HPG46_06830 ENOG4105CJ3 phosphate transporter HPG46_06835 ENOG4107GRR phosphate transport regulator HPG46_06840 ENOG4105BZ4 penicillin-binding protein HPG46_06855 ENOG4105BZU Histidine kinase HPG46_06860 ENOG4105I3N Conserved Protein HPG46_06875 ENOG4105BZU Histidine kinase HPG46_06905 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPG46_06910 ENOG4105DZ1 carboxypeptidase HPG46_06915 ENOG4108JIC nucleoside recognition domain protein HPG46_06925 ENOG4105FE9 pseudouridine synthase HPG46_06935 ENOG4107TWT Cytochrome c biogenesis protein HPG46_06940 ENOG4105CRE cytochrome C HPG46_06945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_06950 ENOG4105BZU Histidine kinase HPG46_06955 ENOG4108WBT adenosyltransferase HPG46_06960 ENOG41063SB peptidase HPG46_06970 ENOG4108SAX Membrane HPG46_06985 ENOG4105C9U ATP-dependent DNA helicase RecQ HPG46_06990 ENOG4105I7S Abortive infection protein HPG46_07000 ENOG4107RGJ metallophosphoesterase HPG46_07005 ENOG4107X2D transcriptional regulator, merr family HPG46_07010 ENOG4108S6Z Negative regulator of genetic competence HPG46_07035 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HPG46_07040 ENOG4105HDK L-asparaginase HPG46_07075 ENOG4105S2F HPG46_07080 ENOG41065D1 HPG46_07110 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HPG46_07125 ENOG4105XXQ heptaprenyl diphosphate synthase component I HPG46_07135 ENOG4105EAH synthase HPG46_07155 ENOG4105CIH Imidazole acetol-phosphate transaminase HPG46_07160 ENOG41068YB TPR repeat-containing protein HPG46_07175 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HPG46_07180 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HPG46_07185 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit HPG46_07215 ENOG4108JYZ YitT family HPG46_07220 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HPG46_07235 ENOG4105FJR Lmbe family HPG46_07240 ENOG4105CPK Glycosyl transferase (Group 1 HPG46_07275 ENOG4105DVT helicase HPG46_07280 ENOG4105YAC HPG46_07300 ENOG4105CSM endonuclease III HPG46_07310 ENOG4105BZ4 penicillin-binding protein HPG46_07365 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HPG46_07375 ENOG4105DVT helicase HPG46_07380 ENOG4105CTD carboxy-peptidase HPG46_07395 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPG46_07410 ENOG4105C2W permease HPG46_07415 ENOG4105DHF Membrane HPG46_07420 ENOG410890F Dynamin family HPG46_07430 ENOG4108W0I acetyltransferase HPG46_07440 ENOG4105KHC sulfurtransferase HPG46_07465 ENOG4106032 Glutathionylspermidine synthase HPG46_07525 ENOG4105CPK Glycosyl transferase (Group 1 HPG46_07540 ENOG4108SZE gCN5-related N-acetyltransferase HPG46_07560 ENOG41081VK Ribonuclease HPG46_07625 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPG46_07635 ENOG4107RWR Sodium hydrogen exchanger HPG46_07640 ENOG4105CN5 Metallo-Beta-Lactamase HPG46_07645 ENOG4108Z5V transcriptional regulator, merr family HPG46_07655 ENOG4105H67 Protein of unknown function (DUF421) HPG46_07660 ENOG41080C8 DUF218 domain HPG46_07715 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HPG46_07725 ENOG4107R0U MotA TolQ exbB proton channel HPG46_07730 ENOG4105ER2 Ompa motb domain protein HPG46_07735 ENOG4107YTP response regulator receiver protein HPG46_07740 ENOG4105CBS Chea signal transduction histidine kinase HPG46_07745 ENOG4105DD5 Flagellar motor switch protein HPG46_07760 ENOG4105BZU Histidine kinase HPG46_07780 ENOG4105E1Q flagellar hook-associated protein HPG46_07785 ENOG4105DTJ flagellar hook-associated protein HPG46_07790 ENOG4107TPX flagellar hook-associated HPG46_07805 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HPG46_07810 ENOG4108ZC9 flagellar basal-body rod protein flgc HPG46_07820 ENOG4107U2N Flagellar M-ring protein HPG46_07825 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPG46_07855 ENOG4105BZE flagellar hook protein, FlgE HPG46_07870 ENOG4107R88 Chemotaxis protein (CheV) HPG46_07910 ENOG4105I03 Flagellin HPG46_07915 ENOG4105E4C Lytic transglycosylase catalytic HPG46_07925 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPG46_07930 ENOG4105DD5 Flagellar motor switch protein HPG46_07940 ENOG4105CN7 Flagellar biosynthetic protein FliP HPG46_07945 ENOG4105VS8 Flagellar biosynthetic protein fliq HPG46_07955 ENOG4105D00 flagellar biosynthetic protein flhB HPG46_07960 ENOG4105D7B Flagellar biosynthesis protein flha HPG46_07965 ENOG4105FZW flagellar biosynthesis regulator FlhF HPG46_07970 ENOG4105KTQ flagellar basal-body rod protein HPG46_07975 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HPG46_08000 ENOG41062JF Transcriptional regulator HPG46_08020 ENOG4105KAC Antibiotic biosynthesis monooxygenase HPG46_08050 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPG46_08055 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HPG46_08060 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HPG46_08065 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HPG46_08120 ENOG4105CVJ phosphoglycerate mutase HPG46_08150 ENOG4105CAQ asparagine synthetase HPG46_08170 ENOG4105PGM cation diffusion facilitator family transporter HPG46_08180 ENOG4105DRR Transcriptional regulator, GntR family HPG46_08185 ENOG4108UZ3 Transporter HPG46_08190 ENOG4105CKI cobalamin synthesis protein HPG46_08195 ENOG4108PJD permease HPG46_08210 ENOG4105DFD Na H antiporter HPG46_08215 ENOG4105C9Q fumarate hydratase class II HPG46_08230 ENOG4105C5X domain protein HPG46_08240 ENOG4107QJQ Mate efflux family protein HPG46_08245 ENOG4105EC3 peptidase S51, dipeptidase E HPG46_08265 ENOG4107QIV Cytochrome c biogenesis protein HPG46_08295 ENOG4106BRA Membrane HPG46_08330 ENOG4105CJ1 ABC, transporter HPG46_08350 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HPG46_08360 ENOG4108IJ0 Aspartate ammonia-lyase HPG46_08365 ENOG4105C6K Malic enzyme HPG46_08400 ENOG41067QW Transcriptional regulator HPG46_08420 ENOG4105FVX HPG46_08460 ENOG4105CSR polyphosphate kinase 2 HPG46_08465 ENOG4105U3E Transcriptional regulator HPG46_08475 ENOG4105DXI Major Facilitator superfamily HPG46_08490 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HPG46_08500 ENOG4105EU0 Major facilitator Superfamily HPG46_08505 ENOG4105C6T cysteine synthase HPG46_08525 ENOG4105C8J )-transporter HPG46_08535 ENOG4105X5K response regulator receiver protein HPG46_08540 ENOG4105H67 Protein of unknown function (DUF421) HPG46_08555 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HPG46_08560 ENOG4105CHR reductase HPG46_08565 ENOG4105CM2 brancheD-chain amino acid aminotransferase HPG46_08570 ENOG4105C7K acetolactate synthase HPG46_08575 ENOG4108ZP8 Acetolactate synthase small subunit HPG46_08580 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HPG46_08590 ENOG4105C7B Threonine dehydratase HPG46_08615 ENOG4105C6X Major Facilitator HPG46_08620 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HPG46_08630 ENOG4107X42 5-methylthioadenosine S-adenosylhomocysteine nucleosidase HPG46_08635 ENOG4105DY9 regulatoR HPG46_08640 ENOG4105CYC Transferase HPG46_08660 ENOG4105F6J Alpha beta hydrolase fold HPG46_08705 ENOG41068WN HPG46_08725 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HPG46_08740 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HPG46_08745 ENOG4105C0X amino acid HPG46_08770 ENOG4107RHR regulatoR HPG46_08780 ENOG4105D9N nucleoside HPG46_08785 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HPG46_08820 ENOG4107RAQ aminopeptidase HPG46_08825 ENOG4107R16 Multicopper oxidase HPG46_08870 ENOG4108T5E Copper resistance protein HPG46_08875 ENOG4105KTB nuclear export factor GLE1 HPG46_08885 ENOG4107RT3 EamA-like transporter family HPG46_08890 ENOG4105GZI Transcriptional regulator HPG46_08895 ENOG4108Z40 Transcriptional regulator HPG46_08900 ENOG4107ZXU DSBA oxidoreductase HPG46_08905 ENOG4108TVJ Nitroreductase HPG46_08915 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPG46_08920 ENOG4106F5Q Membrane HPG46_08935 ENOG4105CKI cobalamin synthesis protein HPG46_08955 ENOG4108Z7G MaoC domain protein dehydratase HPG46_08960 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HPG46_08970 ENOG4105C0Z ABC transporter HPG46_08975 ENOG4108IV0 ABC, transporter HPG46_08980 ENOG4105C32 Amino acid ABC transporter (Permease) HPG46_08990 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family HPG46_09020 ENOG4105C4M (Ubiquinol oxidase) subunit I HPG46_09025 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPG46_09030 ENOG4108JJ9 ABC, transporter HPG46_09035 ENOG4108JJ8 (ABC) transporter HPG46_09050 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPG46_09080 ENOG4105BZ1 (ABC) transporter HPG46_09085 ENOG4105EFI regulatoR HPG46_09090 ENOG4105BZU Histidine kinase HPG46_09105 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HPG46_09115 ENOG4106AKJ HPG46_09130 ENOG4105D6E homoserine dehydrogenase HPG46_09155 ENOG4108KGH TRANSCRIPTIONal HPG46_09165 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPG46_09170 ENOG4105BZU Histidine kinase HPG46_09185 ENOG4105KT7 mgtC SapB transporter HPG46_09190 ENOG4105VRR gCN5-related N-acetyltransferase HPG46_09200 ENOG4105DUU IucA IucC family protein HPG46_09205 ENOG4105CEY Amp-dependent synthetase and ligase HPG46_09220 ENOG4108WBH protein TIM barrel HPG46_09225 ENOG4105YWU small acid-soluble spore protein HPG46_09235 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HPG46_09285 ENOG4105KRN Transcriptional regulator, abrb family HPG46_09295 ENOG4105YVS arsR family transcriptional regulator HPG46_09300 ENOG4107SET aldo keto reductase HPG46_09305 ENOG4107XZQ multidrug resistance protein HPG46_09330 ENOG4105C8Q Methyl-accepting chemotaxis HPG46_09345 ENOG4108K88 Membrane HPG46_09350 ENOG4108WPJ Ferritin-like domain HPG46_09365 ENOG4105DEN Luciferase family HPG46_09385 ENOG4107QM2 Aldo Keto reductase HPG46_09390 ENOG4105CKI cobalamin synthesis protein HPG46_09410 ENOG4108IBT Inherit from COG: transposase HPG46_09415 ENOG4105DSE periplasmic solute binding protein HPG46_09425 ENOG4105K4T epimerase HPG46_09435 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPG46_09460 ENOG4105CVJ phosphoglycerate mutase HPG46_09480 ENOG4107T5V SNARE associated Golgi HPG46_09495 ENOG4108PJD permease HPG46_09505 ENOG4108S4H thioesterase Superfamily protein HPG46_09515 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HPG46_09535 ENOG4105SXS Protein of unknown function (DUF456) HPG46_09540 ENOG4105C37 (CBS) domain HPG46_09560 ENOG4108Z7R Chaperone CsaA HPG46_09580 ENOG4108ZRV stage ii sporulation protein p HPG46_09590 ENOG4108VXD carboxy-peptidase HPG46_09600 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPG46_09620 ENOG4105EFA 4-hydroxyphenylacetate HPG46_09630 ENOG4105U1N riboflavin HPG46_09645 ENOG4105KME endoribonuclease L-psp HPG46_09655 ENOG4105IKQ hydratase HPG46_09675 ENOG41069HH 4-oxalocrotonate tautomerase HPG46_09685 ENOG4108X4Q Hydrolase HPG46_09695 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPG46_09715 ENOG41087PP glycosyltransferase MGT family HPG46_09720 ENOG4108JYZ YitT family HPG46_09725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPG46_09755 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HPG46_09780 ENOG4105KBJ sporulation protein ytfj HPG46_09805 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HPG46_09825 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HPG46_09830 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HPG46_09840 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HPG46_09845 ENOG4105EMN RNA polymerase sigma factor HPG46_09860 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HPG46_09880 ENOG4108V06 Glutathione peroxidase HPG46_09895 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPG46_09915 ENOG4108IUE nitrate reductase beta subunit HPG46_09920 ENOG4105R3A Nitrate reductase HPG46_09930 ENOG4107V6Q Cyclic nucleotide-binding domain HPG46_09935 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPG46_09940 ENOG4105D06 uba thif-type nad fad binding protein HPG46_09945 ENOG4105CVM Molybdenum cofactor synthesis domain protein HPG46_09950 ENOG4108ZAF Molybdopterin HPG46_09975 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HPG46_09980 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HPG46_09985 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HPG46_09990 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HPG46_09995 ENOG4108IFG nitrite reductase, (NAD(P)H) HPG46_10000 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HPG46_10025 ENOG4105MCT stage V sporulation protein S HPG46_10065 ENOG4105C5H ABC transporter HPG46_10080 ENOG4108UUM single-stranded DNA-binding protein HPG46_10100 ENOG4107YX5 Pfam:DUF548 HPG46_10130 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HPG46_10150 ENOG4105C5S asparaginyl-tRNA synthetase HPG46_10170 ENOG4105EC2 ftsk spoIIIe HPG46_10285 ENOG4105BZW Glycerate kinase HPG46_10290 ENOG4107QPK )-transporter HPG46_10295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_10300 ENOG41062D9 Histidine kinase HPG46_10315 ENOG4105C8J )-transporter HPG46_10335 ENOG4107XGZ Hydrolase HPG46_10340 ENOG4105CY2 Citrate transporter HPG46_10345 ENOG4105C0A alcohol dehydrogenase HPG46_10360 ENOG4105KD7 acetyltransferase HPG46_10365 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HPG46_10390 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 HPG46_10410 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) HPG46_10430 ENOG4107RVG penicillin-binding protein HPG46_10440 ENOG4105E9Q Acyl-transferase HPG46_10445 ENOG4108UT2 hemolysin iii HPG46_10455 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HPG46_10465 ENOG4108RCR degv family HPG46_10475 ENOG4108KF3 Electron transport protein SCO1 SenC HPG46_10480 ENOG4107Y70 Heat shock protein HPG46_10485 ENOG4105CAQ asparagine synthetase HPG46_10500 ENOG4108MES Periplasmic binding protein HPG46_10505 ENOG4105F0I Aminotransferase HPG46_10535 ENOG4107Y70 Heat shock protein HPG46_10540 ENOG4105D8X mechanosensitive ion channel HPG46_10545 ENOG4105BZU Histidine kinase HPG46_10550 ENOG4105WH1 Two component transcriptional regulator luxr family HPG46_10585 ENOG4105CMG Carbohydrate kinase HPG46_10590 ENOG4105CMG Carbohydrate kinase HPG46_10620 ENOG4108IJ8 ABC transporter HPG46_10625 ENOG4105E90 ABC transporter HPG46_10660 ENOG4105C37 (CBS) domain HPG46_10685 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPG46_10700 ENOG4107S4Y M20 DapE family protein YgeY HPG46_10705 ENOG4108TSC N-acetyltransferase HPG46_10710 ENOG4108JUB Transcriptional regulator HPG46_10715 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HPG46_10755 ENOG4108N23 SpoOM-related protein HPG46_10760 ENOG410841Q phosphoesterase PA-phosphatase related protein HPG46_10770 ENOG4105SZ6 Thioredoxin HPG46_10830 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HPG46_10885 ENOG4105BZ4 penicillin-binding protein HPG46_10890 ENOG4105CZM Major Facilitator HPG46_10895 ENOG4105W8X HesB YadR YfhF-family protein HPG46_10905 ENOG4105DXD 2-methylcitrate dehydratase HPG46_10910 ENOG4105CR4 methylisocitrate lyase HPG46_10915 ENOG4105C1G acyl-Coa dehydrogenase HPG46_10920 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPG46_10930 ENOG4105N14 lysine exporter protein LysE YggA HPG46_10935 ENOG4105E39 Enoyl-CoA hydratase HPG46_10950 ENOG4107RFY SbcCD D subunit HPG46_10955 ENOG4105EYH Exonuclease HPG46_10970 ENOG4105FCD Major Facilitator HPG46_10975 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HPG46_10980 ENOG4105E4F Isochorismate synthase HPG46_10985 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HPG46_10990 ENOG4105WQI isochorismatase HPG46_10995 ENOG4105CEY Amp-dependent synthetase and ligase HPG46_11000 ENOG4105WQT MbtH domain protein HPG46_11005 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG46_11020 ENOG4105K70 DNA-binding protein HPG46_11040 ENOG4105BZG amino acid carrier protein HPG46_11060 ENOG4105FE9 pseudouridine synthase HPG46_11065 ENOG4105C22 threonyL-tRNA synthetase HPG46_11070 ENOG4105C19 ABC transporter HPG46_11080 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HPG46_11105 ENOG4108D32 Methyltransferase HPG46_11125 ENOG41081I9 integral membrane protein HPG46_11135 ENOG4108Y4K DNA-binding transcriptional activator HPG46_11150 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HPG46_11160 ENOG4105EYF MMPL domain protein HPG46_11185 ENOG4105WCN acetyltransferase HPG46_11215 ENOG4105C1Q protoporphyrinogen oxidase HPG46_11225 ENOG41068WN HPG46_11235 ENOG4105VEQ Cold shock protein HPG46_11255 ENOG410667J hydrolase HPG46_11305 ENOG4107V2S Transcriptional regulator HPG46_11310 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPG46_11325 ENOG4105DND Transcriptional regulator HPG46_11330 ENOG4108RPX mosc domain containing protein HPG46_11345 ENOG4105BZ1 (ABC) transporter HPG46_11350 ENOG4105BZ1 (ABC) transporter HPG46_11370 ENOG4108JCI Transcriptional regulator HPG46_11400 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPG46_11410 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HPG46_11415 ENOG4108KPJ rna polymerase sigma factor HPG46_11440 ENOG4105F32 YngK protein HPG46_11465 ENOG4105RD7 BadF BadG BcrA BcrD HPG46_11475 ENOG4107STF Involved in phosphonate degradation (By similarity) HPG46_11500 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HPG46_11515 ENOG4105C1J atp-dependent rna helicase HPG46_11530 ENOG4108RZE Tetr family transcriptional regulator HPG46_11550 ENOG41088CC tellurite resistance protein tehB HPG46_11560 ENOG4107RA9 decarboxylase HPG46_11565 ENOG41090HR transcriptional regulator HPG46_11605 ENOG4105CIN aminoacyl-histidine dipeptidase HPG46_11630 ENOG4107RF6 penicillin-binding protein HPG46_11635 ENOG4107RF6 penicillin-binding protein HPG46_11645 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HPG46_11650 ENOG4105ETE Transcriptional regulator (LacI family HPG46_11655 ENOG4105IE8 Alpha-ketoglutarate permease HPG46_11660 ENOG4105CK5 oxidoreductase HPG46_11685 ENOG4105D2N Aldolase HPG46_11690 ENOG4105DH8 myo-inositol catabolism HPG46_11700 ENOG4105CGH 5'-nucleotidase HPG46_11725 ENOG4108VXD carboxy-peptidase HPG46_11740 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity HPG46_11745 ENOG41067SE Tetr family transcriptional regulator HPG46_11750 ENOG4105C5H ABC transporter HPG46_11760 ENOG4105BZU Histidine kinase HPG46_11820 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HPG46_11850 ENOG4105C1G acyl-Coa dehydrogenase HPG46_11855 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HPG46_11860 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HPG46_11865 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HPG46_11870 ENOG4105E39 Enoyl-CoA hydratase HPG46_11875 ENOG4107QX3 carboxylase HPG46_11880 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPG46_11890 ENOG4105WCN acetyltransferase HPG46_11895 ENOG4105DBI uridine monophosphokinase HPG46_11905 ENOG4105DZ1 carboxypeptidase HPG46_11920 ENOG4105T9C HD domain HPG46_11930 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HPG46_11970 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HPG46_11985 ENOG4105FQP Beta-lactamase HPG46_11995 ENOG4107Y80 Major Facilitator superfamily HPG46_12015 ENOG4105CUV Homoserine Kinase HPG46_12055 ENOG4105CPQ Dehydrogenase HPG46_12075 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HPG46_12085 ENOG4105DK7 lysyl-tRNA synthetase HPG46_12155 ENOG4105D6E homoserine dehydrogenase HPG46_12170 ENOG4105ETU transcriptional activator (TenA HPG46_12195 ENOG4105VTR Integrase HPG46_12545 ENOG410667J hydrolase HPG46_12550 ENOG4105BZU Histidine kinase HPG46_12555 ENOG4107RF6 penicillin-binding protein HPG46_12575 ENOG4108JJB ABC transporter HPG46_12590 ENOG4108HGU Histidine kinase HPG46_12600 ENOG4105RHY Pfam:UPF0157 HPG46_12605 ENOG4105CB2 alcohol dehydrogenase HPG46_12610 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HPG46_12615 ENOG4105CJN penicillin-binding protein HPG46_12625 ENOG4105FQP Beta-lactamase HPG46_12680 ENOG4107Y80 Major Facilitator superfamily HPG46_12695 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HPG46_12715 ENOG4107Y9U Membrane HPG46_12755 ENOG4105FCD Major Facilitator HPG46_12770 ENOG4105E09 nadh pyrophosphatase HPG46_12775 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HPG46_12780 ENOG4108Z4K mutator MutT protein HPG46_12810 ENOG4108XI2 Domain of unknown function (DUF1963) HPG46_12830 ENOG4108NRW Phospholipase, patatin family HPG46_12835 ENOG4105KWG Pfam:DUF1696 HPG46_12870 ENOG4105PKS Excinuclease abc c subunit domain protein HPG46_12910 ENOG4107VFR oxidoreductase HPG46_12955 ENOG4108IUM Glycogen debranching enzyme HPG46_12980 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HPG46_12990 ENOG4105FDR Membrane HPG46_13050 ENOG4105MSI germination protein ypeb HPG46_13075 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) HPG46_13080 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HPG46_13085 ENOG4107Z3H Transcriptional regulator, TetR family HPG46_13115 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HPG46_13135 ENOG4105E98 transcriptional regulator DeoR family HPG46_13160 ENOG4107QKR Dehydrogenase HPG46_13170 ENOG4107RUY (E1 component), alpha subunit HPG46_13180 ENOG4105E1F short-chain dehydrogenase reductase HPG46_13185 ENOG4105RHY Pfam:UPF0157 HPG46_13195 ENOG4108TIT dATP pyrophosphohydrolase HPG46_13220 ENOG4107SQ8 Glycine betaine HPG46_13225 ENOG4108IJ7 Glycine betaine HPG46_13255 ENOG41082BV acetyltransferase HPG46_13260 ENOG4108M1A Chitin-binding protein HPG46_13280 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HPG46_13295 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HPG46_13325 ENOG4108Z7F N-acetyltransferase HPG46_13345 ENOG4105EEM helicase HPG46_13365 ENOG4105C9U ATP-dependent DNA helicase RecQ HPG46_13415 ENOG4108M1A Chitin-binding protein HPG46_13435 ENOG4105BZG amino acid carrier protein HPG46_13440 ENOG4105C26 Dehydrogenase HPG46_13445 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPG46_13450 ENOG4105CTU Proline racemase HPG46_13455 ENOG4105CTU Proline racemase HPG46_13460 ENOG41080HI glycine oxidase HPG46_13470 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HPG46_13510 ENOG4105DCI Phosphohydrolase HPG46_13515 ENOG4107T5V SNARE associated Golgi HPG46_13530 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HPG46_13535 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPG46_13550 ENOG4105DTQ mandelate racemase muconate lactonizing HPG46_13590 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HPG46_13595 ENOG4105BZU Histidine kinase HPG46_13600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_13635 ENOG4105DPN Oligoendopeptidase f HPG46_13650 ENOG4105EPR degv family HPG46_13705 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HPG46_13710 ENOG4106K7D Major facilitator family transporter HPG46_13730 ENOG4107BMA Transglycosylase associated protein HPG46_13745 ENOG41089UC methyltransferase, type 11 HPG46_13780 ENOG4105CHM Aminotransferase HPG46_13795 ENOG4108ZMI UPF0477 protein HPG46_13855 ENOG4105C02 permease HPG46_13865 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HPG46_13870 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HPG46_13875 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HPG46_13900 ENOG4105E09 nadh pyrophosphatase HPG46_13920 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HPG46_13970 ENOG4107VC0 DNA alkylation repair enzyme HPG46_13990 ENOG4108ZCF integral membrane protein HPG46_13995 ENOG4105E0M Sulfatase HPG46_14000 ENOG4105C5H ABC transporter HPG46_14010 ENOG4105EYF MMPL domain protein HPG46_14015 ENOG41082JN Transcriptional regulator HPG46_14035 ENOG4105CIH Imidazole acetol-phosphate transaminase HPG46_14045 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HPG46_14065 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) HPG46_14080 ENOG41069ER domain protein HPG46_14090 ENOG4105EMN RNA polymerase sigma factor HPG46_14115 ENOG4105D4B ABC, transporter HPG46_14125 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HPG46_14135 ENOG4105DKT Transcriptional regulator HPG46_14140 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HPG46_14150 ENOG41061GT Aldolase HPG46_14170 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HPG46_14200 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HPG46_14205 ENOG4105II7 pyrroline-5-carboxylate reductase HPG46_14215 ENOG4107258 Transcriptional regulator HPG46_14230 ENOG4105ECK Fatty Acid Desaturase HPG46_14235 ENOG4105G6Z alkaline phosphatase HPG46_14245 ENOG4105VMP Transcriptional regulator HPG46_14260 ENOG41090T1 Membrane HPG46_14270 ENOG4108WCX response regulator HPG46_14280 ENOG41068WN HPG46_14305 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPG46_14320 ENOG4105CSH Transporter HPG46_14330 ENOG4105CKK Glycosyl transferase, family 2 HPG46_14350 ENOG4105CKK Glycosyl transferase, family 2 HPG46_14360 ENOG4105C8Y Acetylornithine aminotransferase HPG46_14400 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPG46_14410 ENOG4108TVJ Nitroreductase HPG46_14415 ENOG4105FS7 Transcriptional regulator HPG46_14435 ENOG4105ERH Fumarylacetoacetate hydrolase HPG46_14455 ENOG4105CEY Amp-dependent synthetase and ligase HPG46_14460 ENOG4105CHU acetyl-coa acetyltransferase HPG46_14465 ENOG4105E39 Enoyl-CoA hydratase HPG46_14470 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPG46_14475 ENOG4105CS2 ec 3.2.1.21 HPG46_14480 ENOG4105VCP PTS System HPG46_14485 ENOG4108QVC Component IIC HPG46_14500 ENOG4105VZJ PTS System HPG46_14510 ENOG4105G9B Transcriptional regulator HPG46_14515 ENOG4105D2S major facilitator superfamily HPG46_14520 ENOG4105EFZ amidohydrolase HPG46_14550 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HPG46_14560 ENOG4105C19 ABC transporter HPG46_14590 ENOG4108XET gCN5-related N-acetyltransferase HPG46_14660 ENOG410635A Membrane HPG46_14665 ENOG4105KNA -acetyltransferase HPG46_14670 ENOG4108IQI permease HPG46_14680 ENOG4105F1N DNA alkylation repair HPG46_14710 ENOG4107RF6 penicillin-binding protein HPG46_14745 ENOG4105P4J Allophanate hydrolase, subunit 1 HPG46_14750 ENOG4107258 Transcriptional regulator HPG46_14765 ENOG4106N3A copper homeostasis protein cutc HPG46_14770 ENOG4108ZRV stage ii sporulation protein p HPG46_14775 ENOG4108ZHR arsR family transcriptional regulator HPG46_14785 ENOG4105FDT acyl-CoA dehydrogenase HPG46_14800 ENOG4105DWD nucleoside recognition domain protein HPG46_14830 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HPG46_14895 ENOG4105E2A Dehydrogenase HPG46_14905 ENOG4108IJ0 Aspartate ammonia-lyase HPG46_14910 ENOG4105HDK L-asparaginase HPG46_14915 ENOG4108IMY Transcriptional regulator HPG46_14930 ENOG4105CUB amino acid HPG46_14940 ENOG4105II7 pyrroline-5-carboxylate reductase HPG46_14970 ENOG4105CSV Glutaminase HPG46_15020 ENOG4107QJQ Mate efflux family protein HPG46_15030 ENOG4107QTZ amino acid HPG46_15040 ENOG4105CH6 catalase HPG46_15050 ENOG4105CHJ isochorismatase hydrolase HPG46_15075 ENOG41090MY MarR family Transcriptional regulator HPG46_15115 ENOG4108606 TspO/MBR family HPG46_15120 ENOG4105CVP deoxyribo-dipyrimidine photolyase HPG46_15135 ENOG4108TWJ NADH dehydrogenase subunit 5 HPG46_15140 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HPG46_15155 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPG46_15165 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HPG46_15185 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HPG46_15220 ENOG4105D6J arsenicaL-resistance protein HPG46_15225 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase HPG46_15230 ENOG41085FC arsR family transcriptional regulator HPG46_15250 ENOG4105BZU Histidine kinase HPG46_15255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_15275 ENOG4108IG5 Transcriptional regulator HPG46_15280 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HPG46_15360 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HPG46_15365 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG46_15375 ENOG4105IIP Membrane HPG46_15390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_15395 ENOG41062D9 Histidine kinase HPG46_15420 ENOG4105K6H D-cysteine desulfhydrase HPG46_15445 ENOG4108NNI Beta-lactamase domain-containing protein HPG46_15450 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HPG46_15460 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HPG46_15465 ENOG4105JQZ Methyltransferase HPG46_15485 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) HPG46_15500 ENOG4105BZU Histidine kinase HPG46_15510 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HPG46_15515 ENOG4105DJB Major Facilitator Superfamily HPG46_15525 ENOG4107QR9 Iron-sulfur cluster binding protein HPG46_15535 ENOG4106P55 Transcriptional regulator HPG46_15555 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPG46_15570 ENOG4108JQ1 Dehydrogenase HPG46_15590 ENOG4108AEY RNA polymerase sigma factor HPG46_15605 ENOG41082W1 Cupin 2, conserved barrel domain protein HPG46_15610 ENOG410874W AraC family transcriptional regulator HPG46_15625 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HPG46_15665 ENOG4108ISG Major Facilitator HPG46_15675 ENOG4107MII Sugar-specific transcriptional regulator TrmB HPG46_15680 ENOG4105CZM Major Facilitator HPG46_15695 ENOG4105DA5 (ABC) transporter HPG46_15700 ENOG41069JR HPG46_15710 ENOG4105RXJ HPG46_15715 ENOG4105KPY Small multidrug resistance protein HPG46_15720 ENOG4105KBX Transcriptional regulator, TetR family HPG46_15725 ENOG4107AUC HPG46_15735 ENOG4105CRW Short chain fatty acid transporter HPG46_15745 ENOG4105DYS nad(p)h dehydrogenase (quinone) HPG46_15775 ENOG4108JJB ABC transporter HPG46_15780 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HPG46_15805 ENOG4108K8S endonuclease I HPG46_15820 ENOG41067QW Transcriptional regulator HPG46_15830 ENOG4108Z66 YbaK ebsC protein HPG46_15850 ENOG4105KVH Transcriptional regulator HPG46_15855 ENOG4108RCM Nitroreductase HPG46_15875 ENOG4108PSK reductase HPG46_15885 ENOG4105CJ1 ABC, transporter HPG46_15945 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HPG46_15950 ENOG4105DKQ ROK family HPG46_15955 ENOG4106UW1 Major Facilitator superfamily HPG46_15960 ENOG4108UW5 maltose o-acetyltransferase HPG46_15995 ENOG4105DMQ Methyltransferase HPG46_16005 ENOG4105EV4 Multidrug resistance protein mdtH HPG46_16035 ENOG4105C37 (CBS) domain HPG46_16050 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HPG46_16055 ENOG4105FAW cDP-glucose 4,6-dehydratase HPG46_16085 ENOG4105DDN Pentapeptide repeat-containing protein HPG46_16090 ENOG4105XDF Protein of unknown function (DUF1272) HPG46_16095 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HPG46_16100 ENOG4105CMG Carbohydrate kinase HPG46_16105 ENOG4105C6Z Gluconate HPG46_16110 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HPG46_16125 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HPG46_16130 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HPG46_16135 ENOG4105CIS alcohol dehydrogenase HPG46_16140 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HPG46_16155 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HPG46_16160 ENOG4105D4Y metalloprotease HPG46_16170 ENOG4108UX3 '-nucleotidase HPG46_16175 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HPG46_16180 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HPG46_16185 ENOG4105KVH Transcriptional regulator HPG46_16200 ENOG4105CV8 reductase HPG46_16205 ENOG4105F27 Major Facilitator HPG46_16220 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HPG46_16225 ENOG4105C44 Serine transporter HPG46_16260 ENOG4105KVH Transcriptional regulator HPG46_16265 ENOG4108TZY GntR Family Transcriptional Regulator HPG46_16270 ENOG4105D9R oxidoreductase HPG46_16275 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HPG46_16280 ENOG4105KVH Transcriptional regulator HPG46_16285 ENOG4105KVH Transcriptional regulator HPG46_16325 ENOG4105JAB phenazine biosynthesis protein, phzf family HPG46_16335 ENOG4105CHR reductase HPG46_16345 ENOG4105KNA -acetyltransferase HPG46_16355 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HPG46_16360 ENOG4105KVH Transcriptional regulator HPG46_16415 ENOG4105KAF membrAne HPG46_16440 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HPG46_16455 ENOG4107YXZ hydrolase, family 25 HPG46_16490 ENOG4105H3G oxidoreductase HPG46_16560 ENOG4108TN2 lmbE family HPG46_16570 ENOG4107R3E Citrate transporter HPG46_16585 ENOG4108MES Periplasmic binding protein HPG46_16590 ENOG4105EHG Permease protein HPG46_16595 ENOG4105DQ5 transport system permease protein HPG46_16600 ENOG4105NX3 Membrane HPG46_16605 ENOG4107ZY0 Phenazine biosynthesis-like protein HPG46_16625 ENOG4107CUJ Protein of unknown function (DUF2690) HPG46_16635 ENOG4107V2S Transcriptional regulator HPG46_16655 ENOG4105C98 muts2 protein HPG46_16665 ENOG4105E5K Alpha-amylase HPG46_16670 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HPG46_16675 ENOG4105DPN Oligoendopeptidase f HPG46_16680 ENOG4108A04 Beta-lactamase HPG46_16710 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HPG46_16735 ENOG41082BM Transcriptional regulator, arsr family HPG46_16740 ENOG4105CIS alcohol dehydrogenase HPG46_16760 ENOG4105C09 Bile acid HPG46_16765 ENOG4105CQB FAD linked oxidase domain protein HPG46_16790 ENOG4108UT6 Transferase hexapeptide repeat containing protein HPG46_16800 ENOG4105K64 Glycosyl transferase, family 2 HPG46_16805 ENOG4105E39 Enoyl-CoA hydratase HPG46_16815 ENOG4105KT7 mgtC SapB transporter HPG46_16830 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HPG46_16835 ENOG41073R8 VanW family HPG46_16845 ENOG4108R1P HPG46_16865 ENOG4105VEQ Cold shock protein HPG46_16885 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HPG46_16905 ENOG410904N short-chain dehydrogenase reductase HPG46_16915 ENOG4106IQC argininosuccinate lyase HPG46_16930 ENOG4108IA2 Sodium pantothenate symporter HPG46_16940 ENOG4105C26 Dehydrogenase HPG46_16945 ENOG4105CHR reductase HPG46_16955 ENOG4105EWU Squalene--hopene cyclase HPG46_16965 ENOG4105FR1 rard protein HPG46_16970 ENOG410696E Membrane HPG46_16985 ENOG4105D1F ATP-binding protein HPG46_16995 ENOG4108ZAF Molybdopterin HPG46_17000 ENOG4105CVM Molybdenum cofactor synthesis domain protein HPG46_17005 ENOG4105D06 uba thif-type nad fad binding protein HPG46_17010 ENOG4105TMB Formate nitrite transporter HPG46_17020 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HPG46_17025 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HPG46_17035 ENOG4108JB9 formate dehydrogenase HPG46_17040 ENOG4105E1K spore germination protein HPG46_17100 ENOG4107QJT sodium dicarboxylate symporter HPG46_17105 ENOG4108KGH TRANSCRIPTIONal HPG46_17115 ENOG4105EMN RNA polymerase sigma factor HPG46_17135 ENOG4105CIG ABC transporter HPG46_17145 ENOG4105D9R oxidoreductase HPG46_17155 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPG46_17160 ENOG4105K4P CoA-binding domain protein HPG46_17165 ENOG4105C0H protease HPG46_17170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_17180 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HPG46_17190 ENOG4105W8X HesB YadR YfhF-family protein HPG46_17220 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HPG46_17225 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPG46_17235 ENOG4105BZ1 (ABC) transporter HPG46_17240 ENOG4108I0Z Aconitate hydratase HPG46_17280 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HPG46_17300 ENOG4107F3J Amp-dependent synthetase and ligase HPG46_17305 ENOG4107ZYJ bioY protein HPG46_17310 ENOG4105CEY Amp-dependent synthetase and ligase HPG46_17360 ENOG4107AYK membrAne HPG46_17370 ENOG4105BZU Histidine kinase HPG46_17375 ENOG4105FBA Phospholipase Carboxylesterase HPG46_17380 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HPG46_17385 ENOG4105CK7 Sodium proline symporter HPG46_17390 ENOG4105CBC glutamate synthase HPG46_17395 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPG46_17400 ENOG4108VJ1 Transcriptional regulator (CarD family HPG46_17405 ENOG4108903 Formimidoylglutamase HPG46_17430 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HPG46_17470 ENOG4107QIV Cytochrome c biogenesis protein HPG46_17490 ENOG4105CJ1 ABC, transporter HPG46_17500 ENOG4107RSM transcriptional regulator HPG46_17510 ENOG41067MG lrgb family HPG46_17535 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HPG46_17550 ENOG4105BZ1 (ABC) transporter HPG46_17555 ENOG4105BZ1 (ABC) transporter HPG46_17595 ENOG4105CGH 5'-nucleotidase HPG46_17605 ENOG4108SVB resolvase HPG46_17625 ENOG4105K7K Transcriptional regulator HPG46_17635 ENOG4105C5F glutamine synthetase HPG46_17640 ENOG4105KV4 Transcriptional regulator HPG46_17645 ENOG4105CXI aluminum resistance protein HPG46_17650 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HPG46_17655 ENOG4105EN6 Membrane HPG46_17660 ENOG4106F1P AAA ATPase, central domain protein HPG46_17690 ENOG41069ER domain protein HPG46_17695 ENOG4105DM4 PTS System HPG46_17700 ENOG4105DE4 1-phosphofructokinase HPG46_17705 ENOG4105E98 transcriptional regulator DeoR family HPG46_17710 ENOG4107QW4 alcohol dehydrogenase HPG46_17715 ENOG4108SJC Membrane HPG46_17725 ENOG4105C85 amino acid HPG46_17745 ENOG4105TMB Formate nitrite transporter HPG46_17750 ENOG4105K70 DNA-binding protein HPG46_17760 ENOG4105C59 p-type ATPase HPG46_17765 ENOG410681U heavy metal transport detoxification protein HPG46_17770 ENOG4105VPX protein, conserved in bacteria HPG46_17780 ENOG4105NIV Esterase HPG46_17785 ENOG4105E0A ABC, transporter HPG46_17805 ENOG4105CGK Exodeoxyribonuclease III HPG46_17815 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPG46_17820 ENOG4105D03 DNA-3-methyladenine glycosylase II HPG46_17850 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HPG46_17855 ENOG4105BZU Histidine kinase HPG46_17870 ENOG41067MG lrgb family HPG46_17885 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HPG46_17890 ENOG4107YEI lmbE family HPG46_17915 ENOG4105F0V Cell wall hydrolase HPG46_17920 ENOG4107R6R udp-galactopyranose mutase HPG46_17925 ENOG4105E0M Sulfatase HPG46_17930 ENOG410890F Dynamin family HPG46_17940 ENOG4107QHE Choloylglycine hydrolase HPG46_17970 ENOG4105DQU oxidoreductase, subunit beta HPG46_17975 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HPG46_17980 ENOG4108IGT Dipeptidase HPG46_17985 ENOG4105MCT stage V sporulation protein S HPG46_17990 ENOG4105D48 metallophosphoesterase HPG46_18015 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HPG46_18030 ENOG4105XZV Protein of unknown function (DUF3243) HPG46_18035 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HPG46_18055 ENOG4105UIB (ABC) transporter HPG46_18060 ENOG4108JQ9 ABC transporter HPG46_18065 ENOG4105DIH basic membrane HPG46_18070 ENOG4105FDP GntR family transcriptional regulator HPG46_18080 ENOG4107QZI cell division protein FtsK HPG46_18090 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HPG46_18100 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPG46_18110 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPG46_18115 ENOG4108S0H Dipicolinic acid synthetase, b subunit HPG46_18120 ENOG4105E35 Dipicolinate synthase subunit A HPG46_18130 ENOG4105C1V Peptidase, M16 HPG46_18150 ENOG4105DTN riboflavin biosynthesis protein ribF HPG46_18155 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HPG46_18165 ENOG4105W7A Protein of unknown function (DUF503) HPG46_18175 ENOG4105VHM ribosomal protein HPG46_18180 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HPG46_18185 ENOG4105CHV Transcription elongation factor NusA HPG46_18195 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HPG46_18205 ENOG4105DZP Membrane-associated zinc metalloprotease HPG46_18215 ENOG4105KNE Phosphatidate cytidylyltransferase HPG46_18260 ENOG4108HE4 integrase family HPG46_18270 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HPG46_18275 ENOG4105C79 DNA protecting protein DprA HPG46_18280 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HPG46_18295 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HPG46_18320 ENOG4105VB6 UPF0109 protein HPG46_18340 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HPG46_18345 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HPG46_18360 ENOG4105CHR reductase HPG46_18365 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HPG46_18380 ENOG4105CB5 ATP-dependent DNA helicase recG HPG46_18385 ENOG4105DP4 dak2 domain fusion protein ylov HPG46_18390 ENOG4108ZAA Alkaline-shock protein HPG46_18405 ENOG4105FJ0 thiamine HPG46_18410 ENOG4105DJV ribulose-phosphate 3-epimerase HPG46_18415 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HPG46_18420 ENOG4105D9P serine threonine protein kinase HPG46_18425 ENOG4108ZF3 Phosphatase HPG46_18435 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HPG46_18445 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HPG46_18450 ENOG4105C25 Primosomal protein n' HPG46_18455 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HPG46_18475 ENOG4105DSJ YicC domain protein HPG46_18490 ENOG4105DC7 peptidase M24 HPG46_18575 ENOG4105C34 Pseudouridine synthase HPG46_18600 ENOG4105DBK s4 domain protein HPG46_18605 ENOG41067XK integral membrane protein HPG46_18615 ENOG4105DFA alanine racemase domain protein HPG46_18620 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HPG46_18625 ENOG4105WR5 sporulation protein, YlmC YmxH family HPG46_18635 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG46_18645 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HPG46_18650 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HPG46_18655 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HPG46_18660 ENOG4105D4A Cell wall formation (By similarity) HPG46_18670 ENOG4105CNI cell division protein FtsW HPG46_18685 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HPG46_18690 ENOG4105CJN penicillin-binding protein HPG46_18695 ENOG4105CJN penicillin-binding protein HPG46_18700 ENOG41068DC Essential cell division protein (By similarity) HPG46_18735 ENOG4105KNH Nucleic acid-binding protein HPG46_18745 ENOG41063PX domain protein HPG46_18750 ENOG4105D78 K07001 NTE family protein HPG46_18755 ENOG4105H20 Sporulation integral membrane protein YlbJ HPG46_18765 ENOG4106H78 methyltransferase HPG46_18785 ENOG4107TB6 phosphoglycerate mutase HPG46_18800 ENOG4106UY4 Inherit from COG: Scp-like extracellular HPG46_18850 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HPG46_18855 ENOG4105CNI cell division protein FtsW HPG46_18870 ENOG4108IAB Phoh family HPG46_18890 ENOG4105QA2 HPG46_18895 ENOG4105CI3 gtp-binding protein typa HPG46_18905 ENOG4105ECY inositol monophosphatase HPG46_18925 ENOG4105CXN decarboxylase HPG46_18975 ENOG4105CPP Dehydrogenase, E1 component HPG46_18990 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HPG46_18995 ENOG4108X4Q Hydrolase HPG46_19005 ENOG4105CN5 Metallo-Beta-Lactamase HPG46_19010 ENOG4107ZYR domain protein HPG46_19045 ENOG4108XRC Protein of unknown function (DUF458) HPG46_19055 ENOG4107IN1 Protein of unknown function (DUF1797) HPG46_19070 ENOG4105EPM Diguanylate phosphodiesterase HPG46_19075 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HPG46_19090 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HPG46_19100 ENOG4105UIN HPG46_19155 ENOG4108HGU Histidine kinase HPG46_19165 ENOG4105CHM Aminotransferase HPG46_19170 ENOG4105FKQ transcriptional regulator HPG46_19175 ENOG4105EG2 ABC transporter, permease HPG46_19185 ENOG4107FKK extracellular solute-binding protein family 1 HPG46_19195 ENOG4105CG3 alpha amylase, catalytic region HPG46_19240 ENOG4105CHU acetyl-coa acetyltransferase HPG46_19280 ENOG4105K7K Transcriptional regulator HPG46_19285 ENOG4105DTD Dehydrogenase HPG46_19305 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HPG46_19345 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPG46_19350 ENOG4105BZU Histidine kinase HPG46_19370 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPG46_19385 ENOG4105CID antiterminator HPG46_19405 ENOG4105CE4 GlcNAc 6-P deacetylase HPG46_19440 ENOG4107ZE5 PPIases accelerate the folding of proteins HPG46_19445 ENOG4105PTM secreted protein HPG46_19450 ENOG4105J7I hydrolase HPG46_19460 ENOG4105G6R Stage v sporulation protein ae HPG46_19470 ENOG4105CZ3 stage V sporulation protein ad HPG46_19475 ENOG41090VF Stage v sporulation protein ac HPG46_19495 ENOG4105C8J )-transporter HPG46_19500 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG46_19510 ENOG41082AN stage II sporulation protein HPG46_19515 ENOG4105DZ1 carboxypeptidase HPG46_19520 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HPG46_19525 ENOG4105DVE abc transporter atp-binding protein HPG46_19555 ENOG4105D7N magnesium and cobalt transport protein CorA HPG46_19580 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPG46_19590 ENOG4105I3K Ferric uptake regulator, Fur family HPG46_19595 ENOG4105MZ9 stage II sporulation protein m HPG46_19615 ENOG4105CPC Aldo Keto reductase HPG46_19625 ENOG4105RHY Pfam:UPF0157 HPG46_19645 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HPG46_19655 ENOG4105ETE Transcriptional regulator (LacI family HPG46_19660 ENOG4108YM7 Gcn5-related n-acetyltransferase HPG46_19680 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HPG46_19685 ENOG4108R6K riboflavin synthase, subunit alpha HPG46_19710 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HPG46_19715 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HPG46_19730 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPG46_19740 ENOG4105DFD Na H antiporter HPG46_19745 ENOG4105CGH 5'-nucleotidase HPG46_19785 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HPG46_19800 ENOG4108IXY short-chain dehydrogenase reductase HPG46_19805 ENOG41069FQ Metallo-beta-lactamase superfamily HPG46_19810 ENOG4105II7 pyrroline-5-carboxylate reductase HPG46_19815 ENOG4105EJQ L-serine dehydratase HPG46_19845 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HPG46_19855 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HPG46_19860 ENOG4105D9U N-acetyltransferase HPG46_19875 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HPG46_19880 ENOG4108QEG Membrane HPG46_19885 ENOG4105CDA abc transporter atp-binding protein HPG46_19890 ENOG4105E5Q amino acid AbC transporter HPG46_19895 ENOG4108HW3 (ABC) transporter HPG46_19905 ENOG4105G7B Protein of unknown function (DUF2992) HPG46_19910 ENOG4105E09 nadh pyrophosphatase HPG46_19920 ENOG4105C7S Dehydrogenase HPG46_19925 ENOG4105CPP Dehydrogenase, E1 component HPG46_19945 ENOG4107RDP Dehydrogenase HPG46_19955 ENOG4108JUB Transcriptional regulator HPG46_19965 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HPG46_19980 ENOG4107QQR Sporulation HPG46_19985 ENOG4105S1Z Stage IV sporulation protein B HPG46_19990 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HPG46_20000 ENOG4105DX0 Hemolysin A HPG46_20010 ENOG4105CTB Polyprenyl synthetase HPG46_20035 ENOG4108ZSR alkaline shock protein HPG46_20040 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HPG46_20065 ENOG410644B Stage III sporulation protein af HPG46_20075 ENOG4105KQ4 Stage iii sporulation protein ad HPG46_20080 ENOG4108CQH stage III sporulation protein AC HPG46_20085 ENOG4105KR5 Stage iii sporulation protein HPG46_20090 ENOG4105CD2 stage iii sporulation protein aa HPG46_20115 ENOG4105DC7 peptidase M24 HPG46_20130 ENOG4105CBJ Metal-dependent enzyme HPG46_20140 ENOG4107YBY Hydrolase HPG46_20170 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HPG46_20175 ENOG4105WZW rhodanese family HPG46_20195 ENOG41080TC multidrug resistance protein HPG46_20230 ENOG4105CJ1 ABC, transporter HPG46_20235 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HPG46_20265 ENOG4105C0D helicase HPG46_20380 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HPG46_20385 ENOG4105C3R Methionine synthase HPG46_20395 ENOG4105C28 cystathionine HPG46_20400 ENOG4105C28 cystathionine HPG46_20420 ENOG4105C5X domain protein HPG46_20430 ENOG4105DKQ ROK family HPG46_20440 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HPG46_20455 ENOG4108UTW Plays a role in the regulation of phosphate uptake HPG46_20465 ENOG4105E2Z phosphate ABC transporter (Permease HPG46_20470 ENOG4105C8U phosphate abc transporter HPG46_20475 ENOG4105PWN phosphate abc transporter HPG46_20480 ENOG4107RF6 penicillin-binding protein HPG46_20490 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPG46_20515 ENOG4105N80 Ferric uptake regulator, Fur family HPG46_20525 ENOG4105FDK ABC transporter HPG46_20530 ENOG4108JYZ YitT family HPG46_20535 ENOG41069ZM Protein of unknown function (DUF2624) HPG46_20560 ENOG4105EGD dinuclear metal center protein, YbgI family HPG46_20575 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG46_20580 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HPG46_20605 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HPG46_20610 ENOG4105KG3 cytidine deaminase HPG46_20615 ENOG4107YR5 Diacylglycerol kinase HPG46_20625 ENOG4105CTJ Metal Dependent Phosphohydrolase HPG46_20630 ENOG4105C9A Phoh family HPG46_20640 ENOG41068P3 sporulation protein YqfC HPG46_20645 ENOG4105KTH gatB Yqey HPG46_20655 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HPG46_20660 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HPG46_20690 ENOG4105CSA Coproporphyrinogen iii oxidase HPG46_20695 ENOG4105KVH Transcriptional regulator HPG46_20720 ENOG4105TQK DNA polymerase iii, delta' subunit HPG46_20730 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HPG46_20735 ENOG4108UK2 deaminase HPG46_20740 ENOG4105KQC Competence protein HPG46_20750 ENOG4105DXX methyltransferase HPG46_20760 ENOG4108WF2 Metal Dependent Phosphohydrolase HPG46_20770 ENOG410812S Rna-binding protein HPG46_20780 ENOG4105CQW ribosome biogenesis GTPase YqeH HPG46_20785 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HPG46_20800 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG46_20820 ENOG4108TVJ Nitroreductase HPG46_20835 ENOG4105G6Z alkaline phosphatase HPG46_20845 ENOG4108MUZ hydrolase HPG46_20880 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPG46_20885 ENOG4105MIR Phenylalanine 4-monooxygenase HPG46_20895 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HPG46_20935 ENOG4105S6R Iron-hydroxamate transporter permease subunit HPG46_20940 ENOG4108V5C ABC transporter HPG46_20950 ENOG4105C0A alcohol dehydrogenase HPG46_20955 ENOG4105C28 cystathionine HPG46_20985 ENOG4107XRG penicillin-binding protein HPG46_21000 ENOG4105CFP Peptidase U32 HPG46_21005 ENOG4105XYU peptidase (U32 family) HPG46_21015 ENOG4105HHA aminodeoxychorismate lyase HPG46_21045 ENOG4105C02 permease HPG46_21060 ENOG41060CR HPG46_21065 ENOG4105C7H Helicase, RecD TraA family HPG46_21080 ENOG4105C3J Cysteine desulfurase HPG46_21090 ENOG4105D1H recombination factor protein RarA HPG46_21095 ENOG4108VCI transcription factor, rsfa family HPG46_21100 ENOG4105CUZ uba thif-type nad fad binding protein HPG46_21130 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPG46_21140 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HPG46_21145 ENOG41076HS cation diffusion facilitator family transporter HPG46_21150 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPG46_21160 ENOG4105CKP Polysaccharide Biosynthesis Protein HPG46_21165 ENOG4108QG2 Membrane HPG46_21175 ENOG4105VIE preprotein translocase, subunit YajC HPG46_21190 ENOG41061AI Protein of unknown function (DUF2905) HPG46_21205 ENOG4108HUF Transporter HPG46_21215 ENOG4108IPJ Membrane HPG46_21220 ENOG41082BM Transcriptional regulator, arsr family HPG46_21245 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HPG46_21250 ENOG4108IYU L-aspartate oxidase HPG46_21265 ENOG4108RPX mosc domain containing protein HPG46_21270 ENOG4105CQC Prephenate dehydratase HPG46_21290 ENOG4105EWM Histidine kinase HPG46_21315 ENOG4105X36 (ribosomal) protein HPG46_21325 ENOG4105C03 ribonuclease HPG46_21340 ENOG4107QMS site-determining protein HPG46_21360 ENOG4105DFF Rod shape-determining protein mreb HPG46_21380 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HPG46_21385 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HPG46_21395 ENOG41068KH stage VI sporulation protein D HPG46_21405 ENOG4105D52 delta-aminolevulinic acid dehydratase HPG46_21430 ENOG4105K56 Transcriptional regulator HPG46_21450 ENOG4108IUQ atp-dependent protease HPG46_21480 ENOG4108QCI YvbH-like oligomerisation region HPG46_21500 ENOG4105M59 Phosphodiesterase, mj0936 family HPG46_21515 ENOG4108XJQ germination protein HPG46_21525 ENOG4108PCX Major Facilitator HPG46_21535 ENOG4105KBX Transcriptional regulator, TetR family HPG46_21550 ENOG4105PFC Transcriptional regulator HPG46_21565 ENOG4105DZC cytosine deaminase HPG46_21570 ENOG4105DZC cytosine deaminase HPG46_21575 ENOG4105DEF Extracellular solute-binding protein, family 5 HPG46_21580 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPG46_21595 ENOG4108JQ7 (ABC) transporter HPG46_21600 ENOG4108HRK Histidine kinase HPG46_21605 ENOG4105DY9 regulatoR HPG46_21615 ENOG41067S9 phage shock protein C, PspC HPG46_21620 ENOG4108JCI Transcriptional regulator HPG46_21630 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HPG46_21635 ENOG4108Z40 Transcriptional regulator HPG46_21640 ENOG4105RHA ABC transporter, permease HPG46_21645 ENOG4108IUX (ABC) transporter HPG46_21650 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HPG46_21655 ENOG4105ER2 Ompa motb domain protein HPG46_21660 ENOG4105E14 MotA TolQ exbB proton channel HPG46_21665 ENOG4108VXD carboxy-peptidase HPG46_21675 ENOG4105E33 succinate dehydrogenase HPG46_21685 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HPG46_21700 ENOG4105K63 Thioredoxin HPG46_21705 ENOG4105C10 Electron transfer flavoprotein HPG46_21710 ENOG4105BZJ Electron transfer flavoprotein HPG46_21715 ENOG41060WC Enoyl-CoA hydratase HPG46_21720 ENOG4107Z3H Transcriptional regulator, TetR family HPG46_21725 ENOG4105CEY Amp-dependent synthetase and ligase HPG46_21735 ENOG4105J76 Periplasmic binding protein HPG46_21740 ENOG4105S6R Iron-hydroxamate transporter permease subunit HPG46_21775 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPG46_21790 ENOG4105DR4 Methyltransferase HPG46_21805 ENOG4105KFN sortase, SrtB family HPG46_21810 ENOG4105E0A ABC, transporter HPG46_21825 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) HPG46_21830 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) HPG46_21840 ENOG4105FE9 pseudouridine synthase HPG46_21850 ENOG4105DCG PHP domain protein HPG46_21900 ENOG4108RWN rrna methyltransferase HPG46_21920 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG46_21925 ENOG4105CW7 secretion protein, HlyD family HPG46_21930 ENOG4108JGH Tetr family transcriptional regulator HPG46_21935 ENOG4105CN9 Peptidase m42 family protein HPG46_21960 ENOG4105C22 threonyL-tRNA synthetase HPG46_21965 ENOG4108TDW sporulation protein YtxC HPG46_21990 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HPG46_21995 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HPG46_22010 ENOG4105C2M dna polymerase I HPG46_22015 ENOG4105BZU Histidine kinase HPG46_22020 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPG46_22040 ENOG4108HMX isocitrate dehydrogenase (NADP) HPG46_22045 ENOG4105BZN citrate synthase HPG46_22055 ENOG4108REF Sporulation integral membrane protein ytvi HPG46_22060 ENOG4105FS0 cytoplasmic membrane protein HPG46_22085 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HPG46_22090 ENOG4105C6K Malic enzyme HPG46_22095 ENOG4105C0B DNA polymerase III (alpha subunit) HPG46_22100 ENOG4105VV2 HPG46_22110 ENOG4105SFS phosphoesterase RecJ domain protein HPG46_22145 ENOG4105DC7 peptidase M24 HPG46_22185 ENOG4105Z7P Acetyltransferase (GNAT) family HPG46_22190 ENOG41082W1 Cupin 2, conserved barrel domain protein HPG46_22200 ENOG4105VZ8 Transcriptional regulator HPG46_22220 ENOG4107YZX Universal stress protein HPG46_22260 ENOG4108JYZ YitT family HPG46_22280 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HPG46_22290 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HPG46_22295 ENOG4105KBJ sporulation protein ytfj HPG46_22310 ENOG4105EFZ amidohydrolase HPG46_22320 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPG46_22345 ENOG4106KR7 LysR family Transcriptional regulator HPG46_22355 ENOG4105U5Y Transcriptional regulator HPG46_22365 ENOG4105C28 cystathionine HPG46_22420 ENOG4105EMN RNA polymerase sigma factor HPG46_22435 ENOG4105F1V Acetoin utilization protein HPG46_22440 ENOG4105W87 Cbs domain HPG46_22445 ENOG4105DGU Histone deacetylase HPG46_22460 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPG46_22465 ENOG4105BZU Histidine kinase HPG46_22470 ENOG4107SNB ankyrin repeat protein YahD HPG46_22475 ENOG4105EP9 oxidoreductase HPG46_22505 ENOG4105ETE Transcriptional regulator (LacI family HPG46_22525 ENOG4105C88 aminopeptidase HPG46_22550 ENOG4105K7K Transcriptional regulator HPG46_22580 ENOG4108VDD TRNA binding domain protein HPG46_22610 ENOG4105C8F Beta-lactamase domain protein HPG46_22625 ENOG4108V15 phosphotransferase enzyme family HPG46_22630 ENOG4108IUM Glycogen debranching enzyme HPG46_22640 ENOG4107QSE Dipeptidase HPG46_22645 ENOG4105YW5 deoR family transcriptional regulator HPG46_22660 ENOG4105CBX hi0933 family HPG46_22695 ENOG4108VJ1 Transcriptional regulator (CarD family HPG46_22700 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HPG46_22720 ENOG4108ZAF Molybdopterin HPG46_22725 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HPG46_22730 ENOG4105CVM Molybdenum cofactor synthesis domain protein HPG46_22740 ENOG4105D06 uba thif-type nad fad binding protein HPG46_22745 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPG46_22765 ENOG41085GJ domain protein HPG46_22775 ENOG4105DWV Homoserine O-trans-acetylase HPG46_22785 ENOG4108B31 Spore germination protein HPG46_22815 ENOG410605W Major Facilitator HPG46_22820 ENOG4107S91 Sodium hydrogen exchanger HPG46_22825 ENOG4105NCW Trka-c domain protein HPG46_22840 ENOG4105C19 ABC transporter HPG46_22860 ENOG4105N5T Radical SAM Protein HPG46_22870 ENOG4105CIG ABC transporter HPG46_22915 ENOG4105E8V Alpha Beta Hydrolase Fold protein HPG46_22920 ENOG4108Z0R Transferase HPG46_22925 ENOG4105YVM Phosphoesterase, PA-phosphatase related HPG46_22930 ENOG4105BZF Glycosyl transferase (Group 1 HPG46_22940 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPG46_22995 ENOG4105EGD dinuclear metal center protein, YbgI family HPG46_23000 ENOG4105BZU Histidine kinase HPG46_23005 ENOG4105BZU Histidine kinase HPG46_23010 ENOG4107S9D Alpha beta hydrolase HPG46_23015 ENOG4107T7U Sulfatase HPG46_23030 ENOG4105D2X ABC transporter substrate-binding protein HPG46_23040 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HPG46_23055 ENOG4107XGZ Hydrolase HPG46_23100 ENOG4108V2W Carbonate dehydratase HPG46_23105 ENOG4105C4M (Ubiquinol oxidase) subunit I HPG46_23110 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPG46_23155 ENOG41087YS Phage shock protein A HPG46_23200 ENOG4105BZU Histidine kinase HPG46_23205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_23230 ENOG4108UGV hypoxanthine phosphoribosyltransferase HPG46_23235 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HPG46_23255 ENOG4105C19 ABC transporter HPG46_23270 ENOG4107ZTW SNARE associated Golgi HPG46_23280 ENOG41063TF transcriptional regulator (AraC HPG46_23295 ENOG4105C19 ABC transporter HPG46_23300 ENOG41086D8 Transcriptional regulator HPG46_23355 ENOG4105C6Z Gluconate HPG46_23380 ENOG41069H0 dihydroorotase EC 3.5.2.3 HPG46_23400 ENOG4105DTQ mandelate racemase muconate lactonizing HPG46_23410 ENOG4108IPT Naphthoate synthase HPG46_23415 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HPG46_23420 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HPG46_23425 ENOG4105E4F Isochorismate synthase HPG46_23430 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HPG46_23440 ENOG4105VEQ Cold shock protein HPG46_23485 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPG46_23585 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HPG46_23620 ENOG4105KT7 mgtC SapB transporter HPG46_23625 ENOG4107PBV potassium channel HPG46_23640 ENOG4105WG9 Conserved Protein HPG46_23650 ENOG4105CHM Aminotransferase HPG46_23655 ENOG4108ZB6 transcriptional regulator AsnC family HPG46_23660 ENOG4105C5I Dehydrogenase HPG46_23665 ENOG4108MUZ hydrolase HPG46_23675 ENOG4105C87 Aminotransferase class I and II HPG46_23690 ENOG4105Y38 Kinase-associated protein B HPG46_23700 ENOG4107R3E Citrate transporter HPG46_23720 ENOG4105KA0 thioesterase Superfamily protein HPG46_23735 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPG46_23755 ENOG41069ER domain protein HPG46_23770 ENOG4105CEP NADH dehydrogenase HPG46_23800 ENOG4105EWC Purine nucleoside phosphorylase HPG46_23820 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HPG46_23845 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPG46_23850 ENOG4105C4B ABC transporter, permease HPG46_23855 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HPG46_23880 ENOG41083MR nifu domain-containing protein HPG46_23895 ENOG4108W5N phosphatidylglycerophosphatase a HPG46_23910 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPG46_23915 ENOG4105DYS nad(p)h dehydrogenase (quinone) HPG46_23925 ENOG4105D4U had-superfamily hydrolase, subfamily iia HPG46_23940 ENOG4105CBT Fructose-1,6-bisphosphatase HPG46_23955 ENOG4105MMD transcriptional regulator HPG46_23960 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HPG46_23965 ENOG4107TXC Transcriptional regulator HPG46_23970 ENOG41090T1 Membrane HPG46_23995 ENOG4105FAA peptidase M23 HPG46_24005 ENOG4105KZD Domain of unknown function (DUF1805) HPG46_24010 ENOG4107R8B 5'-nucleotidase HPG46_24025 ENOG4105DIW FeS assembly protein SUFB HPG46_24030 ENOG4108UNV SUF system FeS assembly protein, NifU family HPG46_24035 ENOG4105C9B Cysteine desulfurase HPG46_24040 ENOG4105JRK feS assembly protein SufD HPG46_24045 ENOG4105C3K feS assembly ATPase SufC HPG46_24050 ENOG4105D01 (LipO)protein HPG46_24055 ENOG4105D01 (LipO)protein HPG46_24060 ENOG4108UMI ABC transporter, permease HPG46_24090 ENOG41080E8 Transcriptional regulator, Spx MgsR family HPG46_24160 ENOG4108W8B Beta-lactamase domain protein HPG46_24165 ENOG4105C1G acyl-Coa dehydrogenase HPG46_24170 ENOG4105CHU acetyl-coa acetyltransferase HPG46_24185 ENOG4105DZ1 carboxypeptidase HPG46_24205 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPG46_24225 ENOG4108SUT Major Facilitator Superfamily HPG46_24230 ENOG4107R7I amino acid HPG46_24240 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HPG46_24250 ENOG4107AYK membrAne HPG46_24290 ENOG4107ZTW SNARE associated Golgi HPG46_24300 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPG46_24305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_24310 ENOG4105BZU Histidine kinase HPG46_24330 ENOG4105C8Q Methyl-accepting chemotaxis HPG46_24335 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPG46_24340 ENOG4105VG1 fes assembly suf system protein HPG46_24345 ENOG4105D4Y metalloprotease HPG46_24365 ENOG4107S91 Sodium hydrogen exchanger HPG46_24370 ENOG4105NCW Trka-c domain protein HPG46_24380 ENOG4108RMU ferritin dps family protein HPG46_24395 ENOG4108URH decarboxylase HPG46_24415 ENOG4105D9N nucleoside HPG46_24420 ENOG4105D9N nucleoside HPG46_24435 ENOG4108RYK Nad-dependent epimerase dehydratase HPG46_24455 ENOG4105CV8 reductase HPG46_24460 ENOG4105F27 Major Facilitator HPG46_24465 ENOG4105KVH Transcriptional regulator HPG46_24480 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HPG46_24485 ENOG4105D4A Cell wall formation (By similarity) HPG46_24495 ENOG4105C8Q Methyl-accepting chemotaxis HPG46_24525 ENOG4108MK9 spermidine N(1)-acetyltransferase HPG46_24545 ENOG4108IPW abc transporter atp-binding protein HPG46_24550 ENOG4105CM4 permease protein HPG46_24565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_24585 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HPG46_24595 ENOG4105XZU Preprotein translocase, subunit SecG HPG46_24600 ENOG41067MG lrgb family HPG46_24650 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG46_24695 ENOG41090VF Stage v sporulation protein ac HPG46_24700 ENOG4105CZ3 stage V sporulation protein ad HPG46_24715 ENOG4105H67 Protein of unknown function (DUF421) HPG46_24725 ENOG4105KRI phosphocarrier protein (HPr HPG46_24735 ENOG4105CHW UPF0052 protein HPG46_24745 ENOG4108Z4K mutator MutT protein HPG46_24755 ENOG4105C3M thioredoxin reductase HPG46_24765 ENOG4108S4C acetyltransferase HPG46_24785 ENOG41086DT Membrane protein of unknown function HPG46_24795 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HPG46_24815 ENOG4107TXC Transcriptional regulator HPG46_24845 ENOG4105HMI Membrane HPG46_24850 ENOG4105DUM transcriptional regulator, lysR family HPG46_24860 ENOG4108WS4 fmn reductase HPG46_24875 ENOG4105BZ1 (ABC) transporter HPG46_24880 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HPG46_24885 ENOG4107RSM transcriptional regulator HPG46_24895 ENOG4105CN1 protease HPG46_24900 ENOG4105CRP Part of the ABC transporter FtsEX involved in HPG46_24905 ENOG4105CAK Cell division ATP-binding protein ftsE HPG46_24925 ENOG4105MS2 ribosomal subunit Interface protein HPG46_24930 ENOG4105VEQ Cold shock protein HPG46_24935 ENOG41081UC Inherit from COG: Competence protein HPG46_24945 ENOG4105K4H Nlp p60 protein HPG46_24950 ENOG4105KVH Transcriptional regulator HPG46_24960 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HPG46_24965 ENOG4108KGH TRANSCRIPTIONal HPG46_24970 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPG46_24975 ENOG4105C6Y Udp-glucose 6-dehydrogenase HPG46_24980 ENOG4105ESV Glycosyl transferase, family 4 HPG46_24990 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPG46_25010 ENOG4105F8D glycoside hydrolase family 4 HPG46_25015 ENOG4105VCP PTS System HPG46_25020 ENOG4105CK1 PTS System HPG46_25030 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HPG46_25040 ENOG4105VCP PTS System HPG46_25050 ENOG4105VZJ PTS System HPG46_25065 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HPG46_25070 ENOG4105ECB domain protein HPG46_25075 ENOG4107RSM transcriptional regulator HPG46_25135 ENOG4105DAA L-lactate HPG46_25145 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) HPG46_25155 ENOG4105E0M Sulfatase HPG46_25180 ENOG4107R8N Glycosyl transferase, family 2 HPG46_25185 ENOG4105C94 Transporter HPG46_25190 ENOG41069ER domain protein HPG46_25215 ENOG4105KBK Zinc finger, swim domain protein HPG46_25220 ENOG4105C0D helicase HPG46_25250 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG46_25260 ENOG4107RBB ABC transporter, permease HPG46_25265 ENOG4105C19 ABC transporter HPG46_25285 ENOG4105CXY transporter HPG46_25300 ENOG4105BZU Histidine kinase HPG46_25305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_25310 ENOG4105CMR udp-glucose 4-epimerase HPG46_25335 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPG46_25340 ENOG4105EY8 ABC transporter HPG46_25390 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HPG46_25395 ENOG4107BJW polysaccharide deacetylase HPG46_25405 ENOG4105FRN stage II sporulation protein HPG46_25420 ENOG4105DY9 regulatoR HPG46_25440 ENOG4106778 Protein of unknown function (DUF1146) HPG46_25445 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPG46_25450 ENOG4105C8S subunit m HPG46_25455 ENOG4105D65 subunit l HPG46_25480 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPG46_25485 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HPG46_25500 ENOG4105BZU Histidine kinase HPG46_25550 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HPG46_25555 ENOG41062M3 atp synthase HPG46_25585 ENOG4108YZG isomerase HPG46_25600 ENOG4108VGI doxx family HPG46_25605 ENOG4107XC4 flavin reductase domain protein, FMN-binding HPG46_25620 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HPG46_25630 ENOG4108ZXQ stage ii sporulation protein r HPG46_25635 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HPG46_25655 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HPG46_25660 ENOG4105CBT Fructose-1,6-bisphosphatase HPG46_25700 ENOG4105C1G acyl-Coa dehydrogenase HPG46_25705 ENOG4105C1G acyl-Coa dehydrogenase HPG46_25710 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPG46_25720 ENOG4105DF6 Fe-S oxidoreductase HPG46_25735 ENOG4105BZU Histidine kinase HPG46_25760 ENOG4105BZU Histidine kinase HPG46_25765 ENOG4105KCT ABC transporter HPG46_25770 ENOG4108M15 ABC transporter HPG46_25775 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HPG46_25785 ENOG4105IIU Aminopeptidase HPG46_25805 ENOG4105EMN RNA polymerase sigma factor HPG46_25815 ENOG410684U Domain of unknown function (DUF1934) HPG46_25835 ENOG4105CYW agmatinase HPG46_25845 ENOG4105DXB Major Facilitator superfamily HPG46_25850 ENOG4107SWG transcriptional regulator MERR family HPG46_25855 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HPG46_25860 ENOG4105BZ4 penicillin-binding protein HPG46_25865 ENOG4108XFG YwhD family HPG46_25870 ENOG4108Z4T Peptidase M50 HPG46_25875 ENOG41069HH 4-oxalocrotonate tautomerase HPG46_25880 ENOG4105DCI Phosphohydrolase HPG46_25885 ENOG4108MES Periplasmic binding protein HPG46_25890 ENOG4105E0A ABC, transporter HPG46_25895 ENOG4105EHG Permease protein HPG46_25900 ENOG4105DQ5 transport system permease protein HPG46_25910 ENOG4108VCI transcription factor, rsfa family HPG46_25925 ENOG4108IJ2 phosphate acetyltransferase HPG46_25940 ENOG4108VKI Cell wall hydrolase HPG46_25960 ENOG4107SVH Potassium channel protein HPG46_25970 ENOG410667J hydrolase HPG46_25975 ENOG4105VCH membrane HPG46_25985 ENOG4108TU7 Inherit from COG: (ABC) transporter HPG46_25990 ENOG4105CJ1 ABC, transporter HPG46_25995 ENOG41090WU lipolytic protein G-D-S-L family HPG46_26010 ENOG4105D6E homoserine dehydrogenase HPG46_26035 ENOG4108Y4K DNA-binding transcriptional activator HPG46_26045 ENOG4105WH1 Two component transcriptional regulator luxr family HPG46_26050 ENOG4105BZU Histidine kinase HPG46_26055 ENOG4105DWF phosphomethylpyrimidine kinase HPG46_26060 ENOG4105BZU Histidine kinase HPG46_26065 ENOG4105VCD cytoplasmic protein HPG46_26070 ENOG4105D22 carbon starvation protein HPG46_26075 ENOG4105DY9 regulatoR HPG46_26080 ENOG41079KZ Major Facilitator Superfamily HPG46_26100 ENOG4105EN6 Membrane HPG46_26105 ENOG4106YBV Methyl-accepting chemotaxis HPG46_26115 ENOG4108S4H thioesterase Superfamily protein HPG46_26125 ENOG4105JEU Glycosyl transferase, family 2 HPG46_26130 ENOG4105C5H ABC transporter HPG46_26150 ENOG4105CKK Glycosyl transferase, family 2 HPG46_26155 ENOG41067SE Tetr family transcriptional regulator HPG46_26165 ENOG4105E0X reductase HPG46_26170 ENOG4106F5Q Membrane HPG46_26185 ENOG4105DY9 regulatoR HPG46_26190 ENOG4108HRK Histidine kinase HPG46_26195 ENOG4107RGD Major Facilitator superfamily HPG46_26210 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPG46_26220 ENOG4105IW1 AmiS UreI transporter HPG46_26230 ENOG4105CMR udp-glucose 4-epimerase HPG46_26235 ENOG4108UT2 hemolysin iii HPG46_26245 ENOG4105C1J atp-dependent rna helicase HPG46_26260 ENOG4105DPN Oligoendopeptidase f HPG46_26280 ENOG4105C0H protease HPG46_26285 ENOG4105Q2H domain protein HPG46_26300 ENOG4105BZU Histidine kinase HPG46_26305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_26335 ENOG4105CDU Replicative dna helicase HPG46_26345 ENOG4105BZR domain protein HPG46_26350 ENOG4108XMW Membrane HPG46_26360 ENOG4108UUM single-stranded DNA-binding protein HPG46_26370 ENOG4105C3G gtp-binding protein HPG46_26375 ENOG4105VDK protein, conserved in bacteria HPG46_26380 ENOG4105D8X mechanosensitive ion channel HPG46_26385 ENOG4108ZDA Sporulation protein YyaC HPG46_26390 ENOG4105FA0 parb-like partition protein HPG46_26395 ENOG4107QJE Chromosome Partitioning Protein HPG46_26425 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HPG46_26445 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HPG46_26450 ENOG410848D S4 domain protein YaaA HPG46_26465 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPG46_26500 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HPG46_26535 ENOG4105ZMH deoxynucleoside kinase HPG46_26545 ENOG4105GTG Isochorismatase HPG46_26550 ENOG4108Z6B deaminase HPG46_26560 ENOG4105C6E dna polymerase iii HPG46_26580 ENOG41067KS pro-sigma K processing HPG46_26615 ENOG4105CXN decarboxylase HPG46_26625 ENOG4105FA2 dna polymerase iii HPG46_26630 ENOG4105MA4 psp1 domain protein HPG46_26640 ENOG41060K3 Methyltransferase HPG46_26650 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HPG46_26655 ENOG4105KRN Transcriptional regulator, abrb family HPG46_26665 ENOG4105F8V Hydrolase, tatD family HPG46_26670 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) HPG46_26680 ENOG4105XFA sporulation peptidase YabG HPG46_26685 ENOG4105W42 Veg protein HPG46_26700 ENOG4105DFT pur operon repressor HPG46_26705 ENOG4105KME endoribonuclease L-psp HPG46_26735 ENOG4108JA2 transcriptioN-repair coupling factor HPG46_26740 ENOG4108M14 stage v sporulation protein t HPG46_26750 ENOG4108IY2 MazG family HPG46_26755 ENOG41082I2 s4 domain protein HPG46_26760 ENOG4105VYY sporulation protein yabp HPG46_26775 ENOG41060GV RNA binding s1 domain protein HPG46_26800 ENOG4108UGV hypoxanthine phosphoribosyltransferase HPG46_26805 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HPG46_26820 ENOG4105C6T cysteine synthase HPG46_26825 ENOG4105CRQ synthase (Component I) HPG46_26830 ENOG4105DDQ anthranilate synthase HPG46_26835 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HPG46_26840 ENOG4105EEI dihydropteroate synthase HPG46_26845 ENOG4105KRF dihydroneopterin aldolase HPG46_26850 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HPG46_26860 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPG46_26895 ENOG4105D7V transposase HPG46_26905 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPG46_26950 ENOG4108IMY Transcriptional regulator HPG46_26955 ENOG4105BZC d-serine deaminase HPG46_26970 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPG46_27015 ENOG4105MZU cell filamentation protein HPG46_27025 ENOG4105EJQ L-serine dehydratase HPG46_27030 ENOG4105C44 Serine transporter HPG46_27045 ENOG4108JGH Tetr family transcriptional regulator HPG46_27050 ENOG4105EQ0 Major Facilitator superfamily HPG46_27055 ENOG4105MZU cell filamentation protein HPG46_27065 ENOG4107QJQ Mate efflux family protein HPG46_27080 ENOG4107QTZ amino acid HPG46_27115 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HPG46_27120 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HPG46_27135 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) HPG46_27145 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase HPG46_27150 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HPG46_27155 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HPG46_27160 ENOG4107RBJ symporter HPG46_27165 ENOG4108R6W Transcriptional regulator, ARAC family HPG46_27175 ENOG4105IIP Membrane HPG46_27180 ENOG4106AM8 polysaccharide lyase family 8 HPG46_27190 ENOG4105EP8 Glycosyl Hydrolase Family 88 HPG46_27195 ENOG4105DAS pts system HPG46_27200 ENOG4105F3R pts system mannose fructose sorbose family iid HPG46_27205 ENOG4105ETZ PTS System HPG46_27215 ENOG4105CHR reductase HPG46_27220 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) HPG46_27225 ENOG4105D7K pfkb domain protein HPG46_27235 ENOG4106P37 HTH-type transcriptional regulator YjhI HPG46_27290 ENOG4107XGZ Hydrolase HPG46_27295 ENOG41067FT ParB-like nuclease domain HPG46_27300 ENOG4107R8B 5'-nucleotidase HPG46_27325 ENOG4105CIH Imidazole acetol-phosphate transaminase HPG46_27350 ENOG4105E5W Transporter HPG46_27380 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPG46_27405 ENOG4105W8Z 4'-phosphopantetheinyl transferase HPG46_27440 ENOG4108MEK Metal-binding protein YodA HPG46_27455 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HPG46_27610 ENOG4107SET aldo keto reductase HPG46_27630 ENOG4105VTR Integrase HPG46_27815 ENOG4105K70 DNA-binding protein HPG46_27825 ENOG4105D7V transposase HPG46_27890 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPG46_27895 ENOG4105WH1 Two component transcriptional regulator luxr family HPG46_27900 ENOG4108XG2 Histidine kinase HPG46_27980 ENOG4105E4C Lytic transglycosylase catalytic HPG46_28020 ENOG4105IIU Aminopeptidase HPG46_28110 ENOG4105T09 s-layer domain-containing protein HPG46_28120 ENOG4108M1A Chitin-binding protein HPG46_28140 ENOG4107SDU Methyl-accepting chemotaxis HPG46_28185 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HPG46_28230 ENOG4105D7V transposase HPG46_28275 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HPG46_28290 ENOG4105CNU cell division protein FtsK HPG46_28490 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HPG46_28600 ENOG4105DR5 peptidase HPG46_28605 ENOG4105D4Y metalloprotease HPG46_28625 ENOG4105F6J Alpha beta hydrolase fold HPG46_28630 ENOG4105DHF Membrane HPG46_28690 ENOG41067QW Transcriptional regulator HPG46_28700 ENOG4105D7V transposase HPG46_28715 ENOG41061CK Antibiotic biosynthesis monooxygenase HPG46_28760 ENOG4105W8Z 4'-phosphopantetheinyl transferase HPG46_28800 ENOG4105FQP Beta-lactamase HPG46_28810 ENOG4108IG5 Transcriptional regulator HPG46_28820 ENOG4105EMU Dehydrogenase HPG46_28845 ENOG410849A acetyltransferase, (GNAT) family HPG46_28870 ENOG41067QW Transcriptional regulator