locus-tag	class	description
HPG46_00085	COG3880	PFAM UvrB UvrC protein
HPG46_00095	COG0542	response to heat
HPG46_00100	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPG46_00110	COG4956	integral membrane protein (PIN domain superfamily)
HPG46_00130	COG1045	serine acetyltransferase
HPG46_00145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPG46_00150	COG3688	RNA-binding protein containing a PIN domain
HPG46_00165	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPG46_00170	COG0250	Participates in transcription elongation, termination and antitermination
HPG46_00175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPG46_00195	COG2813	Specifically methylates the guanine in position
HPG46_00210	COG1358	cellular component organization or biogenesis
HPG46_00280	COG0255	Belongs to the universal ribosomal protein uL29 family
HPG46_00340	COG0201	protein transport
HPG46_00350	COG0024	Methionine aminopeptidase
HPG46_00360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPG46_00395	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPG46_00420	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_00425	COG0489	protein tyrosine kinase activity
HPG46_00435	COG2194	sulfuric ester hydrolase activity
HPG46_00440	COG0726	polysaccharide deacetylase
HPG46_00520	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HPG46_00525	COG4856	YbbR-like protein
HPG46_00550	COG0596	Alpha beta hydrolase
HPG46_00570	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPG46_00580	COG1506	peptidase
HPG46_00580	COG0823	Involved in the tonB-independent uptake of proteins
HPG46_00580	COG4946	Tricorn protease homolog
HPG46_00600	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_00605	COG2011	ABC-type metal ion transport system permease component
HPG46_00610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPG46_00615	COG1464	Belongs to the NlpA lipoprotein family
HPG46_00620	COG0604	alcohol dehydrogenase
HPG46_00630	COG0277	FAD linked oxidase domain protein
HPG46_00635	COG2271	Major facilitator Superfamily
HPG46_00645	COG2814	Major facilitator Superfamily
HPG46_00660	COG0601	transmembrane transport
HPG46_00665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPG46_00670	COG0444	Belongs to the ABC transporter superfamily
HPG46_00675	COG4608	Belongs to the ABC transporter superfamily
HPG46_00680	COG4166	transmembrane transport
HPG46_00690	COG2207	Transcriptional regulator
HPG46_00705	COG4166	transmembrane transport
HPG46_00710	COG4166	transmembrane transport
HPG46_00715	COG0656	L-ascorbic acid biosynthetic process
HPG46_00720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_00735	COG4149	molybdate abc transporter
HPG46_00740	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPG46_00745	COG1910	domain protein
HPG46_00760	COG0697	spore germination
HPG46_00775	COG0204	Acyl-transferase
HPG46_00785	COG1609	Transcriptional regulator
HPG46_00795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_00815	COG5298	Protein conserved in bacteria
HPG46_00835	COG0488	(ABC) transporter
HPG46_00850	COG0747	negative chemotaxis
HPG46_00855	COG0601	transmembrane transport
HPG46_00860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPG46_00865	COG0444	Belongs to the ABC transporter superfamily
HPG46_00870	COG4608	Belongs to the ABC transporter superfamily
HPG46_00875	COG0561	phosphatase activity
HPG46_00905	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HPG46_00910	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPG46_00920	COG0531	amino acid
HPG46_00925	COG2814	Major facilitator Superfamily
HPG46_00935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPG46_00945	COG4294	response to UV
HPG46_00950	COG0705	Rhomboid family
HPG46_00950	COG0457	Tetratricopeptide repeat
HPG46_00960	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPG46_00965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPG46_00970	COG0864	Transcriptional regulator
HPG46_00975	COG2337	Toxic component of a toxin-antitoxin (TA) module
HPG46_00980	COG2183	response to ionizing radiation
HPG46_01075	COG0802	atpase or kinase
HPG46_01080	COG1214	PFAM Peptidase M22, glycoprotease
HPG46_01085	COG0456	acetyltransferase
HPG46_01095	COG0488	(ABC) transporter
HPG46_01110	COG1266	CAAX protease self-immunity
HPG46_01130	COG2252	PERMEase
HPG46_01140	COG5002	protein histidine kinase activity
HPG46_01165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HPG46_01195	COG2226	methyltransferase
HPG46_01205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPG46_01215	COG1215	transferase activity, transferring glycosyl groups
HPG46_01255	COG2205	protein histidine kinase activity
HPG46_01260	COG0745	RESPONSE REGULATOR receiver
HPG46_01280	COG0697	spore germination
HPG46_01305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPG46_01310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPG46_01315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPG46_01325	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPG46_01340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPG46_01350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPG46_01360	COG0151	Belongs to the GarS family
HPG46_01385	COG0210	DNA helicase
HPG46_01395	COG4851	CamS sex pheromone cAM373 precursor
HPG46_01415	COG1335	isochorismatase
HPG46_01420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPG46_01425	COG2011	ABC-type metal ion transport system permease component
HPG46_01430	COG1464	Belongs to the NlpA lipoprotein family
HPG46_01445	COG0003	Pfam Anion-transporting ATPase
HPG46_01450	COG1846	Transcriptional regulator
HPG46_01455	COG4682	membrane
HPG46_01475	COG1597	lipid kinase activity
HPG46_01480	COG0546	phosphoglycolate phosphatase activity
HPG46_01485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPG46_01495	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_01500	COG2076	Multidrug Resistance protein
HPG46_01505	COG2309	aminopeptidase activity
HPG46_01520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_01525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPG46_01530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPG46_01535	COG5002	protein histidine kinase activity
HPG46_01540	COG4807	Protein conserved in bacteria
HPG46_01565	COG1757	Na H antiporter
HPG46_01570	COG1473	amidohydrolase
HPG46_01585	COG0450	alkyl hydroperoxide reductase
HPG46_01605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_01610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_01615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_01630	COG0166	Belongs to the GPI family
HPG46_01685	COG3541	Predicted nucleotidyltransferase
HPG46_01690	COG2814	Major facilitator Superfamily
HPG46_01695	COG0723	plastoquinol--plastocyanin reductase activity
HPG46_01695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_01705	COG0765	amino acid transport
HPG46_01710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_01720	COG0840	transmembrane signaling receptor activity
HPG46_01725	COG0840	transmembrane signaling receptor activity
HPG46_01730	COG0366	Alpha amylase catalytic
HPG46_01735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_01735	COG2190	(PTS) system
HPG46_01735	COG1263	PTS System
HPG46_01765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPG46_01780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPG46_01790	COG1116	anion transmembrane transporter activity
HPG46_01800	COG0488	(ABC) transporter
HPG46_01850	COG2270	Major facilitator Superfamily
HPG46_01880	COG2310	stress, protein
HPG46_01885	COG2310	stress, protein
HPG46_01890	COG2310	stress, protein
HPG46_01895	COG0861	Integral membrane protein TerC family
HPG46_01905	COG3853	Toxic anion resistance protein (TelA)
HPG46_01920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPG46_01930	COG1295	ribonuclease BN
HPG46_01935	COG2217	Heavy metal translocating P-type atpase
HPG46_01940	COG0697	spore germination
HPG46_01950	COG0681	Belongs to the peptidase S26 family
HPG46_01960	COG0586	Pfam SNARE associated Golgi protein
HPG46_01975	COG3871	stress protein (general stress protein 26)
HPG46_01980	COG0387	Pfam Sodium calcium exchanger
HPG46_01990	COG0535	radical SAM domain protein
HPG46_02010	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPG46_02015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPG46_02030	COG3829	transcription factor binding
HPG46_02040	COG0833	amino acid
HPG46_02045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPG46_02075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_02075	COG1263	PTS System
HPG46_02080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_02100	COG0463	Glycosyl transferase, family 2
HPG46_02110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPG46_02110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPG46_02130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPG46_02150	COG1228	amidohydrolase
HPG46_02155	COG1090	epimerase
HPG46_02185	COG1988	membrane-bound metal-dependent
HPG46_02190	COG1194	a g-specific adenine glycosylase
HPG46_02215	COG1132	(ABC) transporter
HPG46_02220	COG4129	membrane
HPG46_02225	COG0067	glutamate synthase
HPG46_02225	COG0069	glutamate synthase activity
HPG46_02225	COG0070	glutamate synthase
HPG46_02235	COG4555	ABC transporter
HPG46_02255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPG46_02260	COG0735	belongs to the Fur family
HPG46_02375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPG46_02380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPG46_02390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPG46_02400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPG46_02410	COG2766	serine protein kinase
HPG46_02430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPG46_02440	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPG46_02445	COG2268	Band 7 protein
HPG46_02455	COG3290	protein histidine kinase activity
HPG46_02460	COG4565	transcriptional regulatory protein
HPG46_02465	COG2851	Citrate transporter
HPG46_02485	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HPG46_02490	COG3842	ATPase activity
HPG46_02495	COG1175	transmembrane transport
HPG46_02500	COG0395	ABC-type sugar transport system, permease component
HPG46_02510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPG46_02515	COG0745	RESPONSE REGULATOR receiver
HPG46_02520	COG5002	protein histidine kinase activity
HPG46_02530	COG4990	cell redox homeostasis
HPG46_02540	COG3290	protein histidine kinase activity
HPG46_02545	COG4565	transcriptional regulatory protein
HPG46_02550	COG3493	citrate carrier protein
HPG46_02555	COG0281	malic enzyme
HPG46_02570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_02580	COG5002	protein histidine kinase activity
HPG46_02585	COG0745	RESPONSE REGULATOR receiver
HPG46_02590	COG0454	-acetyltransferase
HPG46_02590	COG0456	acetyltransferase
HPG46_02595	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPG46_02600	COG3383	formate dehydrogenase (NAD+) activity
HPG46_02605	COG2427	Protein of unknown function (DUF1641)
HPG46_02620	COG0531	amino acid
HPG46_02625	COG0640	Transcriptional regulator
HPG46_02630	COG2217	Heavy metal translocating P-type atpase
HPG46_02635	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPG46_02650	COG3227	Zinc metalloprotease (Elastase)
HPG46_02670	COG2720	vancomycin resistance protein
HPG46_02675	COG1316	TRANSCRIPTIONal
HPG46_02680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_02685	COG0346	lactoylglutathione lyase activity
HPG46_02690	COG1253	flavin adenine dinucleotide binding
HPG46_02695	COG1027	Aspartate ammonia-lyase
HPG46_02700	COG1620	l-lactate permease
HPG46_02715	COG3104	oligopeptide transport
HPG46_02720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_02725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_02730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_02740	COG2226	methyltransferase
HPG46_02745	COG0156	8-amino-7-oxononanoate synthase activity
HPG46_02750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPG46_02755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPG46_02765	COG4548	von Willebrand factor, type A
HPG46_02770	COG0714	Associated with various cellular activities
HPG46_02775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_02795	COG0531	amino acid
HPG46_02800	COG2188	Transcriptional regulator
HPG46_02805	COG1263	PTS System
HPG46_02805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_02810	COG0366	Alpha amylase catalytic
HPG46_02825	COG0697	spore germination
HPG46_02835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPG46_02840	COG1115	amino acid carrier protein
HPG46_02845	COG1126	abc transporter atp-binding protein
HPG46_02850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_02855	COG0765	amino acid transport
HPG46_02860	COG0765	amino acid transport
HPG46_02865	COG0833	amino acid
HPG46_02890	COG2378	regulation of single-species biofilm formation
HPG46_02895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPG46_02900	COG5002	protein histidine kinase activity
HPG46_02915	COG0659	secondary active sulfate transmembrane transporter activity
HPG46_02930	COG0747	negative chemotaxis
HPG46_02940	COG0601	transmembrane transport
HPG46_02945	COG4608	Belongs to the ABC transporter superfamily
HPG46_02955	COG2271	Major facilitator Superfamily
HPG46_02960	COG1846	Transcriptional regulator
HPG46_02965	COG0477	Major facilitator Superfamily
HPG46_02970	COG1609	Transcriptional regulator
HPG46_02975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPG46_02990	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPG46_02995	COG1879	ABC-type sugar transport system periplasmic component
HPG46_03015	COG1063	alcohol dehydrogenase
HPG46_03030	COG3568	Endonuclease Exonuclease Phosphatase
HPG46_03060	COG0840	transmembrane signaling receptor activity
HPG46_03065	COG3584	3D domain protein
HPG46_03065	COG1388	LysM domain
HPG46_03070	COG1476	TRANSCRIPTIONal
HPG46_03085	COG3104	oligopeptide transport
HPG46_03090	COG1114	Component of the transport system for branched-chain amino acids
HPG46_03095	COG1464	Belongs to the NlpA lipoprotein family
HPG46_03100	COG1960	acyl-CoA dehydrogenase activity
HPG46_03105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPG46_03110	COG2011	ABC-type metal ion transport system permease component
HPG46_03125	COG1113	amino acid transport
HPG46_03130	COG2252	PERMEase
HPG46_03145	COG2153	protein acetylation
HPG46_03155	COG0569	domain protein
HPG46_03155	COG0475	glutathione-regulated potassium exporter activity
HPG46_03170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPG46_03175	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPG46_03180	COG0833	amino acid
HPG46_03185	COG4990	cell redox homeostasis
HPG46_03200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPG46_03205	COG0697	spore germination
HPG46_03210	COG0531	amino acid
HPG46_03220	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPG46_03225	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPG46_03230	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPG46_03230	COG1918	ferrous iron import across plasma membrane
HPG46_03235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPG46_03240	COG0573	inorganic phosphate transmembrane transporter activity
HPG46_03245	COG0581	inorganic phosphate transmembrane transporter activity
HPG46_03255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPG46_03375	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HPG46_03395	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPG46_03400	COG1116	anion transmembrane transporter activity
HPG46_03405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPG46_03410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPG46_03415	COG0352	thiamine-phosphate diphosphorylase activity
HPG46_03420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_03425	COG2104	thiamine diphosphate biosynthetic process
HPG46_03435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPG46_03440	COG0351	phosphomethylpyrimidine kinase
HPG46_03480	COG2205	protein histidine kinase activity
HPG46_03485	COG2814	Major facilitator Superfamily
HPG46_03490	COG1846	Transcriptional regulator
HPG46_03515	COG1136	(ABC) transporter
HPG46_03515	COG0577	efflux transmembrane transporter activity
HPG46_03525	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPG46_03535	COG1879	ABC-type sugar transport system periplasmic component
HPG46_03540	COG2252	PERMEase
HPG46_03545	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_03550	COG1376	ErfK ybiS ycfS ynhG family protein
HPG46_03565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_03605	COG0778	Nitroreductase
HPG46_03610	COG2719	SpoVR family
HPG46_03615	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPG46_03620	COG1937	Protein conserved in bacteria
HPG46_03625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_03625	COG0425	Belongs to the sulfur carrier protein TusA family
HPG46_03630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_03630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_03635	COG0425	Belongs to the sulfur carrier protein TusA family
HPG46_03640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_03650	COG2210	Belongs to the sulfur carrier protein TusA family
HPG46_03655	COG0730	response to heat
HPG46_03665	COG1316	TRANSCRIPTIONal
HPG46_03670	COG0604	alcohol dehydrogenase
HPG46_03675	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPG46_03690	COG3711	transcriptional antiterminator
HPG46_03690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPG46_03695	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPG46_03700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_03720	COG3584	3D domain protein
HPG46_03720	COG1388	LysM domain
HPG46_03725	COG0577	efflux transmembrane transporter activity
HPG46_03730	COG1136	(ABC) transporter
HPG46_03740	COG5522	Integral membrane protein (intg_mem_TP0381)
HPG46_03755	COG1114	Component of the transport system for branched-chain amino acids
HPG46_03760	COG3546	catalase activity
HPG46_03795	COG0586	Pfam SNARE associated Golgi protein
HPG46_03830	COG0531	amino acid
HPG46_03835	COG0475	glutathione-regulated potassium exporter activity
HPG46_03845	COG1737	Transcriptional regulator
HPG46_03855	COG1263	PTS System
HPG46_03855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_03865	COG2259	Doxx family
HPG46_03880	COG0697	spore germination
HPG46_03885	COG1522	sequence-specific DNA binding
HPG46_03900	COG2076	Multidrug Resistance protein
HPG46_03905	COG1309	transcriptional regulator
HPG46_03910	COG2814	Major facilitator Superfamily
HPG46_03915	COG0657	acetylesterase activity
HPG46_03920	COG1309	transcriptional regulator
HPG46_03925	COG2124	cytochrome p450
HPG46_03935	COG1063	alcohol dehydrogenase
HPG46_03940	COG4533	DNA binding
HPG46_03945	COG2211	Major facilitator Superfamily
HPG46_03955	COG0693	protein deglycase activity
HPG46_03960	COG0693	protein deglycase activity
HPG46_03960	COG0753	catalase activity
HPG46_03970	COG0531	amino acid
HPG46_03985	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_03990	COG1132	(ABC) transporter
HPG46_03995	COG1132	(ABC) transporter
HPG46_04000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_04005	COG0765	amino acid transport
HPG46_04010	COG1126	abc transporter atp-binding protein
HPG46_04025	COG0189	ligase activity
HPG46_04055	COG0028	Belongs to the TPP enzyme family
HPG46_04060	COG3527	Alpha-acetolactate decarboxylase
HPG46_04070	COG0561	phosphatase activity
HPG46_04075	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPG46_04075	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_04080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPG46_04085	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_04095	COG0659	secondary active sulfate transmembrane transporter activity
HPG46_04120	COG0653	protein targeting
HPG46_04125	COG2244	polysaccharide biosynthetic process
HPG46_04135	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_04140	COG4196	transglutaminase domain protein
HPG46_04155	COG1696	Membrane protein involved in D-alanine export
HPG46_04170	COG1024	Enoyl-CoA hydratase
HPG46_04195	COG1363	Peptidase, m42
HPG46_04215	COG3938	Belongs to the proline racemase family
HPG46_04255	COG0601	transmembrane transport
HPG46_04260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPG46_04265	COG0444	Belongs to the ABC transporter superfamily
HPG46_04270	COG4608	Belongs to the ABC transporter superfamily
HPG46_04285	COG0477	Major facilitator Superfamily
HPG46_04290	COG3290	protein histidine kinase activity
HPG46_04295	COG4565	transcriptional regulatory protein
HPG46_04300	COG3181	Tripartite tricarboxylate transporter family receptor
HPG46_04345	COG4978	Transcriptional regulator
HPG46_04345	COG0789	Transcriptional regulator
HPG46_04360	COG0305	Participates in initiation and elongation during chromosome replication
HPG46_04400	COG0477	Major facilitator Superfamily
HPG46_04445	COG3320	Male sterility
HPG46_04445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPG46_04450	COG1309	transcriptional regulator
HPG46_04465	COG1183	phosphatidylcholine synthase activity
HPG46_04485	COG2376	Dihydroxyacetone kinase
HPG46_04495	COG2376	Dihydroxyacetone kinase
HPG46_04505	COG1959	2 iron, 2 sulfur cluster binding
HPG46_04595	COG1136	(ABC) transporter
HPG46_04600	COG0577	efflux transmembrane transporter activity
HPG46_04655	COG1191	sigma factor activity
HPG46_04665	COG2208	phosphoserine phosphatase activity
HPG46_04670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPG46_04675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_04675	COG0784	Response regulator, receiver
HPG46_04675	COG2198	Histidine kinase
HPG46_04675	COG2205	protein histidine kinase activity
HPG46_04730	COG0420	3'-5' exonuclease activity
HPG46_04735	COG4717	serine-type aminopeptidase activity
HPG46_04770	COG0346	lactoylglutathione lyase activity
HPG46_04775	COG0346	lactoylglutathione lyase activity
HPG46_04780	COG0457	Tetratricopeptide repeat
HPG46_04790	COG2267	carboxylic ester hydrolase activity
HPG46_04810	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HPG46_04815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPG46_04825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPG46_04870	COG0477	Major facilitator Superfamily
HPG46_04875	COG0477	Major facilitator Superfamily
HPG46_04885	COG3973	AAA domain
HPG46_04890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPG46_04910	COG4980	gas vesicle protein
HPG46_04915	COG0537	adenosine 5'-monophosphoramidase activity
HPG46_04920	COG1131	(ABC) transporter
HPG46_04925	COG4473	ABC transporter
HPG46_04980	COG1309	transcriptional regulator
HPG46_04990	COG3402	PFAM membrane-flanked domain
HPG46_04995	COG3428	Bacterial PH domain
HPG46_05035	COG3402	PFAM membrane-flanked domain
HPG46_05040	COG3428	Bacterial PH domain
HPG46_05045	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_05050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_05065	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HPG46_05100	COG1309	transcriptional regulator
HPG46_05105	COG1511	domain protein
HPG46_05130	COG2378	regulation of single-species biofilm formation
HPG46_05135	COG1609	Transcriptional regulator
HPG46_05145	COG1234	tRNA 3'-trailer cleavage
HPG46_05150	COG0095	Lipoate-protein ligase
HPG46_05160	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_05180	COG1408	metallophosphoesterase
HPG46_05190	COG1078	dGTPase activity
HPG46_05200	COG1595	DNA-templated transcription, initiation
HPG46_05205	COG2207	Transcriptional regulator
HPG46_05205	COG3708	Transcriptional regulator
HPG46_05220	COG2205	protein histidine kinase activity
HPG46_05225	COG0745	RESPONSE REGULATOR receiver
HPG46_05250	COG0501	Belongs to the peptidase M48B family
HPG46_05255	COG0840	transmembrane signaling receptor activity
HPG46_05260	COG0697	spore germination
HPG46_05280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPG46_05285	COG2224	Isocitrate lyase
HPG46_05310	COG4903	ComK protein
HPG46_05315	COG0398	Pfam SNARE associated Golgi protein
HPG46_05375	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPG46_05400	COG0367	asparagine synthase
HPG46_05405	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPG46_05410	COG0753	catalase activity
HPG46_05415	COG0004	ammonium transporteR
HPG46_05435	COG2996	Protein conserved in bacteria
HPG46_05445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPG46_05455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_05470	COG0561	phosphatase activity
HPG46_05480	COG0542	response to heat
HPG46_05490	COG2267	carboxylic ester hydrolase activity
HPG46_05505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_05510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPG46_05515	COG5504	Zn-dependent protease
HPG46_05525	COG0180	Tryptophanyl-tRNA synthetase
HPG46_05535	COG4166	transmembrane transport
HPG46_05540	COG0601	transmembrane transport
HPG46_05545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPG46_05550	COG0444	Belongs to the ABC transporter superfamily
HPG46_05555	COG4608	Belongs to the ABC transporter superfamily
HPG46_05560	COG0534	Mate efflux family protein
HPG46_05565	COG4166	transmembrane transport
HPG46_05580	COG0861	Integral membrane protein TerC family
HPG46_05585	COG4862	establishment of competence for transformation
HPG46_05590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_05600	COG1164	Oligoendopeptidase f
HPG46_05615	COG2346	COG2346, Truncated hemoglobins
HPG46_05620	COG4116	CYTH
HPG46_05630	COG2357	RelA SpoT domain protein
HPG46_05640	COG0564	pseudouridine synthase activity
HPG46_05655	COG0772	Belongs to the SEDS family
HPG46_05660	COG0463	Glycosyl transferase, family 2
HPG46_05660	COG1216	Glycosyl transferase, family 2
HPG46_05680	COG0457	Tetratricopeptide repeat
HPG46_05680	COG0463	Glycosyl transferase, family 2
HPG46_05700	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HPG46_05715	COG1091	dTDP-4-dehydrorhamnose reductase activity
HPG46_05760	COG2153	protein acetylation
HPG46_05770	COG2382	esterase
HPG46_05785	COG5492	domain, Protein
HPG46_05790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPG46_05800	COG0512	Glutamine amidotransferase of anthranilate synthase
HPG46_05800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPG46_05835	COG1620	l-lactate permease
HPG46_05840	COG5634	Uncharacterized conserved protein (DUF2278)
HPG46_05895	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPG46_05905	COG1476	TRANSCRIPTIONal
HPG46_05960	COG2226	methyltransferase
HPG46_05970	COG1686	Belongs to the peptidase S11 family
HPG46_05975	COG0681	Belongs to the peptidase S26 family
HPG46_06010	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_06020	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPG46_06025	COG1177	transmembrane transport
HPG46_06030	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPG46_06040	COG2409	Drug exporters of the RND superfamily
HPG46_06050	COG0564	pseudouridine synthase activity
HPG46_06060	COG2340	Cysteine-rich secretory protein family
HPG46_06065	COG0247	lactate metabolic process
HPG46_06070	COG0277	FAD linked oxidase domain protein
HPG46_06075	COG3835	regulator
HPG46_06085	COG0745	RESPONSE REGULATOR receiver
HPG46_06090	COG5002	protein histidine kinase activity
HPG46_06095	COG2186	Transcriptional regulator
HPG46_06115	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HPG46_06125	COG2116	formate transmembrane transporter activity
HPG46_06130	COG0861	Integral membrane protein TerC family
HPG46_06135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPG46_06145	COG2030	dehydratase
HPG46_06165	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_06170	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPG46_06175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_06180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPG46_06195	COG1840	ABC-type Fe3 transport system, periplasmic component
HPG46_06200	COG3842	ATPase activity
HPG46_06225	COG1349	DNA-binding transcription factor activity
HPG46_06235	COG0235	Class ii aldolase
HPG46_06245	COG2861	carbohydrate metabolic process
HPG46_06255	COG3852	Histidine kinase
HPG46_06260	COG1846	Transcriptional regulator
HPG46_06270	COG2318	DinB family
HPG46_06275	COG5002	protein histidine kinase activity
HPG46_06285	COG0720	synthase
HPG46_06300	COG4873	Protein conserved in bacteria
HPG46_06330	COG1780	Probably involved in ribonucleotide reductase function
HPG46_06350	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPG46_06355	COG1725	Transcriptional regulator
HPG46_06360	COG1131	(ABC) transporter
HPG46_06370	COG1131	(ABC) transporter
HPG46_06375	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPG46_06390	COG1522	sequence-specific DNA binding
HPG46_06410	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPG46_06415	COG2070	2-Nitropropane dioxygenase
HPG46_06420	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HPG46_06430	COG1696	Membrane protein involved in D-alanine export
HPG46_06455	COG0716	FMN binding
HPG46_06470	COG3173	Aminoglycoside phosphotransferase
HPG46_06495	COG1968	undecaprenyl-diphosphatase activity
HPG46_06510	COG1846	Transcriptional regulator
HPG46_06520	COG1301	dicarboxylic acid transport
HPG46_06525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPG46_06530	COG4709	membrane
HPG46_06535	COG3874	Sporulation protein YtfJ
HPG46_06555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPG46_06560	COG0028	Belongs to the TPP enzyme family
HPG46_06565	COG0440	acetolactate synthase activity
HPG46_06640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPG46_06655	COG1183	phosphatidylcholine synthase activity
HPG46_06660	COG1368	sulfuric ester hydrolase activity
HPG46_06670	COG0019	diaminopimelate decarboxylase activity
HPG46_06690	COG0529	Catalyzes the synthesis of activated sulfate
HPG46_06695	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPG46_06715	COG1648	precorrin-2 dehydrogenase activity
HPG46_06720	COG0733	neurotransmitter:sodium symporter activity
HPG46_06740	COG1757	Na H antiporter
HPG46_06755	COG4758	membrane
HPG46_06760	COG4585	Histidine kinase
HPG46_06765	COG2197	response regulator
HPG46_06775	COG1114	Component of the transport system for branched-chain amino acids
HPG46_06785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPG46_06825	COG0730	response to heat
HPG46_06830	COG0306	phosphate transporter
HPG46_06835	COG1392	Phosphate transport regulator
HPG46_06840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_06855	COG3852	Histidine kinase
HPG46_06860	COG1801	Protein of unknown function DUF72
HPG46_06870	COG0582	viral genome integration into host DNA
HPG46_06875	COG5002	protein histidine kinase activity
HPG46_06890	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HPG46_06890	COG0392	lysyltransferase activity
HPG46_06905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPG46_06910	COG1686	Belongs to the peptidase S11 family
HPG46_06915	COG2715	membrane protein required for spore maturation
HPG46_06920	COG0700	Nucleoside recognition
HPG46_06925	COG1187	pseudouridine synthase activity
HPG46_06935	COG1333	cytochrome c biogenesis protein
HPG46_06940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPG46_06945	COG0745	RESPONSE REGULATOR receiver
HPG46_06950	COG5002	protein histidine kinase activity
HPG46_06955	COG2096	Adenosyltransferase
HPG46_06960	COG4942	peptidase
HPG46_06970	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HPG46_06975	COG1141	Ferredoxin
HPG46_06985	COG0514	ATP-dependent DNA helicase (RecQ)
HPG46_06990	COG1266	CAAX protease self-immunity
HPG46_07000	COG1408	metallophosphoesterase
HPG46_07010	COG4862	establishment of competence for transformation
HPG46_07015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPG46_07035	COG0492	ferredoxin-NADP+ reductase activity
HPG46_07110	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPG46_07125	COG0142	geranyltranstransferase activity
HPG46_07135	COG0142	geranyltranstransferase activity
HPG46_07155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPG46_07160	COG0457	Tetratricopeptide repeat
HPG46_07180	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPG46_07190	COG4347	Protein of unknown function (DUF1405)
HPG46_07205	COG2738	Putative neutral zinc metallopeptidase
HPG46_07215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_07220	COG1694	Mazg nucleotide pyrophosphohydrolase
HPG46_07235	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPG46_07240	COG0438	transferase activity, transferring glycosyl groups
HPG46_07275	COG1199	ATP-dependent helicase activity
HPG46_07275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPG46_07295	COG3935	DnaD domain protein
HPG46_07300	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPG46_07310	COG4499	WXG100 protein secretion system (Wss), protein YukC
HPG46_07310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_07365	COG0116	Belongs to the methyltransferase superfamily
HPG46_07375	COG1199	ATP-dependent helicase activity
HPG46_07380	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPG46_07390	COG3173	Aminoglycoside phosphotransferase
HPG46_07395	COG0024	Methionine aminopeptidase
HPG46_07410	COG2233	PERMEase
HPG46_07415	COG2311	Membrane
HPG46_07420	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPG46_07430	COG0456	acetyltransferase
HPG46_07465	COG0754	glutathionylspermidine amidase activity
HPG46_07480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPG46_07505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPG46_07520	COG1215	transferase activity, transferring glycosyl groups
HPG46_07525	COG0438	transferase activity, transferring glycosyl groups
HPG46_07540	COG0454	-acetyltransferase
HPG46_07560	COG0328	RNA-DNA hybrid ribonuclease activity
HPG46_07595	COG3403	YqcI/YcgG family
HPG46_07600	COG1280	lysine exporter protein (LysE YggA)
HPG46_07615	COG3162	membrane
HPG46_07620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPG46_07625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPG46_07635	COG0475	glutathione-regulated potassium exporter activity
HPG46_07640	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPG46_07645	COG0789	Transcriptional regulator
HPG46_07645	COG4978	Transcriptional regulator
HPG46_07655	COG2323	membrane
HPG46_07660	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPG46_07715	COG1923	regulation of RNA biosynthetic process
HPG46_07725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPG46_07730	COG1360	Flagellar Motor Protein
HPG46_07735	COG2201	protein-glutamate methylesterase activity
HPG46_07740	COG2198	Histidine kinase
HPG46_07740	COG0643	Histidine kinase
HPG46_07745	COG1776	CheC inhibitor of MCP methylation
HPG46_07745	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPG46_07760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPG46_07780	COG1256	bacterial-type flagellum assembly
HPG46_07785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPG46_07790	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPG46_07805	COG1815	bacterial-type flagellum-dependent cell motility
HPG46_07810	COG1558	bacterial-type flagellum-dependent cell motility
HPG46_07820	COG1766	The M ring may be actively involved in energy transduction
HPG46_07825	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPG46_07835	COG1157	protein secretion by the type III secretion system
HPG46_07870	COG0784	Response regulator, receiver
HPG46_07870	COG0835	chemotaxis
HPG46_07910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPG46_07915	COG0741	lytic transglycosylase activity
HPG46_07925	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPG46_07930	COG1776	CheC inhibitor of MCP methylation
HPG46_07930	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPG46_07940	COG1338	Plays a role in the flagellum-specific transport system
HPG46_07945	COG1987	bacterial-type flagellum assembly
HPG46_07955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPG46_07960	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPG46_07965	COG1419	protein localization to endoplasmic reticulum
HPG46_07970	COG4786	Flagellar basal body rod
HPG46_07975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPG46_08020	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_08045	COG0583	DNA-binding transcription factor activity
HPG46_08050	COG3842	ATPase activity
HPG46_08055	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPG46_08065	COG1234	tRNA 3'-trailer cleavage
HPG46_08120	COG0406	alpha-ribazole phosphatase activity
HPG46_08150	COG0367	asparagine synthase
HPG46_08180	COG1802	Transcriptional regulator
HPG46_08185	COG0697	spore germination
HPG46_08190	COG0523	cobalamin synthesis protein
HPG46_08195	COG0701	Predicted permease
HPG46_08205	COG0438	transferase activity, transferring glycosyl groups
HPG46_08205	COG1216	Glycosyl transferase, family 2
HPG46_08210	COG1757	Na H antiporter
HPG46_08215	COG0114	fumarate hydratase activity
HPG46_08230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_08240	COG0534	Mate efflux family protein
HPG46_08245	COG3340	Belongs to the peptidase S51 family
HPG46_08265	COG0785	Cytochrome C biogenesis protein
HPG46_08295	COG2733	membrane
HPG46_08330	COG1131	(ABC) transporter
HPG46_08345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_08350	COG0528	UMP kinase activity
HPG46_08360	COG1027	Aspartate ammonia-lyase
HPG46_08365	COG0281	malic enzyme
HPG46_08370	COG4191	Histidine kinase
HPG46_08375	COG0784	Response regulator, receiver
HPG46_08380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPG46_08400	COG3620	sequence-specific DNA binding
HPG46_08425	COG1051	belongs to the nudix hydrolase family
HPG46_08430	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_08440	COG2814	Major facilitator Superfamily
HPG46_08465	COG1695	Transcriptional regulator
HPG46_08475	COG0477	Major facilitator Superfamily
HPG46_08480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_08490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPG46_08495	COG4166	transmembrane transport
HPG46_08500	COG2223	nitrite transmembrane transporter activity
HPG46_08505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPG46_08520	COG2244	polysaccharide biosynthetic process
HPG46_08525	COG0733	neurotransmitter:sodium symporter activity
HPG46_08535	COG5566	PFAM Mor transcription activator
HPG46_08540	COG2323	membrane
HPG46_08555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPG46_08565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPG46_08570	COG0028	Belongs to the TPP enzyme family
HPG46_08575	COG0440	acetolactate synthase activity
HPG46_08580	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPG46_08590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPG46_08615	COG2814	Major facilitator Superfamily
HPG46_08620	COG3384	dioxygenase
HPG46_08630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPG46_08635	COG3279	Response regulator of the LytR AlgR family
HPG46_08640	COG0427	acetyl-CoA hydrolase
HPG46_08660	COG1073	alpha beta
HPG46_08665	COG4166	transmembrane transport
HPG46_08700	COG0535	radical SAM domain protein
HPG46_08705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_08725	COG1914	H( )-stimulated, divalent metal cation uptake system
HPG46_08740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPG46_08745	COG0531	amino acid
HPG46_08770	COG2390	Transcriptional regulator
HPG46_08780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_08785	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPG46_08820	COG0006	proline dipeptidase activity
HPG46_08825	COG2132	Multicopper oxidase
HPG46_08840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPG46_08860	COG1114	Component of the transport system for branched-chain amino acids
HPG46_08870	COG1276	copper resistance
HPG46_08870	COG2372	response to copper ion
HPG46_08875	COG4549	nuclear export factor GLE1
HPG46_08885	COG0697	spore germination
HPG46_08890	COG0583	DNA-binding transcription factor activity
HPG46_08895	COG1959	2 iron, 2 sulfur cluster binding
HPG46_08900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HPG46_08905	COG0778	Nitroreductase
HPG46_08920	COG0628	permease
HPG46_08930	COG1231	oxidoreductase activity
HPG46_08935	COG0523	cobalamin synthesis protein
HPG46_08950	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_08955	COG2030	dehydratase
HPG46_08960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_08970	COG0411	ABC transporter
HPG46_08990	COG0583	DNA-binding transcription factor activity
HPG46_09000	COG1942	4-Oxalocrotonate Tautomerase
HPG46_09020	COG1271	oxidase subunit
HPG46_09025	COG1294	oxidase, subunit
HPG46_09030	COG4988	ABC transporter
HPG46_09035	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPG46_09050	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPG46_09055	COG1686	Belongs to the peptidase S11 family
HPG46_09070	COG0791	NLP P60 protein
HPG46_09070	COG1388	LysM domain
HPG46_09080	COG1132	(ABC) transporter
HPG46_09085	COG0745	RESPONSE REGULATOR receiver
HPG46_09090	COG5002	protein histidine kinase activity
HPG46_09095	COG0300	oxidoreductase activity
HPG46_09100	COG4122	O-methyltransferase activity
HPG46_09115	COG5658	integral membrane protein
HPG46_09130	COG0460	homoserine dehydrogenase
HPG46_09155	COG1316	TRANSCRIPTIONal
HPG46_09165	COG0745	RESPONSE REGULATOR receiver
HPG46_09170	COG5002	protein histidine kinase activity
HPG46_09185	COG1285	pathogenesis
HPG46_09190	COG1247	-acetyltransferase
HPG46_09210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPG46_09220	COG1082	Xylose isomerase domain protein TIM barrel
HPG46_09230	COG2814	Major facilitator Superfamily
HPG46_09235	COG1279	arginine transmembrane transporter activity
HPG46_09245	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPG46_09280	COG0577	efflux transmembrane transporter activity
HPG46_09285	COG2002	toxin-antitoxin pair type II binding
HPG46_09290	COG1404	Belongs to the peptidase S8 family
HPG46_09295	COG0640	Transcriptional regulator
HPG46_09300	COG0667	Aldo Keto reductase
HPG46_09305	COG2814	Major facilitator Superfamily
HPG46_09330	COG0840	transmembrane signaling receptor activity
HPG46_09345	COG3949	Membrane
HPG46_09350	COG0783	Belongs to the Dps family
HPG46_09365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPG46_09375	COG1231	oxidoreductase activity
HPG46_09385	COG4989	oxidoreductase activity
HPG46_09390	COG0523	cobalamin synthesis protein
HPG46_09395	COG0456	acetyltransferase
HPG46_09415	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPG46_09415	COG3443	Belongs to the bacterial solute-binding protein 9 family
HPG46_09425	COG0702	epimerase
HPG46_09435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPG46_09445	COG4166	transmembrane transport
HPG46_09460	COG0406	alpha-ribazole phosphatase activity
HPG46_09470	COG5337	Spore coat protein CotH
HPG46_09475	COG1051	belongs to the nudix hydrolase family
HPG46_09480	COG0586	Pfam SNARE associated Golgi protein
HPG46_09485	COG2244	polysaccharide biosynthetic process
HPG46_09495	COG0701	Predicted permease
HPG46_09500	COG3689	TIGRFAM TIGR03943 family protein
HPG46_09505	COG1607	acyl-coa hydrolase
HPG46_09515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_09530	COG0702	epimerase
HPG46_09535	COG2839	Protein conserved in bacteria
HPG46_09540	COG1253	flavin adenine dinucleotide binding
HPG46_09555	COG1114	Component of the transport system for branched-chain amino acids
HPG46_09560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPG46_09580	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_09590	COG1876	peptidase activity
HPG46_09600	COG0154	amidase activity
HPG46_09605	COG2211	Major facilitator Superfamily
HPG46_09620	COG2368	4-hydroxyphenylacetate
HPG46_09630	COG0196	riboflavin kinase activity
HPG46_09645	COG0251	oxidation-reduction process
HPG46_09655	COG3971	2-oxopent-4-enoate hydratase activity
HPG46_09675	COG1942	4-Oxalocrotonate Tautomerase
HPG46_09685	COG0561	phosphatase activity
HPG46_09695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPG46_09700	COG4106	trans-aconitate 2-methyltransferase activity
HPG46_09715	COG1819	glycosyl
HPG46_09720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_09725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_09755	COG0456	acetyltransferase
HPG46_09780	COG3874	Sporulation protein YtfJ
HPG46_09805	COG2226	methyltransferase
HPG46_09825	COG1082	Xylose isomerase domain protein TIM barrel
HPG46_09830	COG0346	lactoylglutathione lyase activity
HPG46_09840	COG0604	alcohol dehydrogenase
HPG46_09845	COG1595	DNA-templated transcription, initiation
HPG46_09860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPG46_09880	COG0386	Belongs to the glutathione peroxidase family
HPG46_09885	COG1305	Transglutaminase-like
HPG46_09890	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HPG46_09895	COG0714	Associated with various cellular activities
HPG46_09910	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPG46_09915	COG1140	nitrate reductase beta subunit
HPG46_09920	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPG46_09925	COG2181	nitrate reductase activity
HPG46_09930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPG46_09935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPG46_09940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPG46_09945	COG0303	'Molybdopterin
HPG46_09950	COG0314	molybdopterin synthase activity
HPG46_09960	COG2223	nitrite transmembrane transporter activity
HPG46_09975	COG1648	precorrin-2 dehydrogenase activity
HPG46_09985	COG1587	Uroporphyrinogen-III synthase
HPG46_09985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPG46_09990	COG2146	nitrite reductase [NAD(P)H] activity
HPG46_09995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPG46_10000	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HPG46_10025	COG2359	stage V sporulation protein S
HPG46_10060	COG1418	mRNA catabolic process
HPG46_10065	COG0488	(ABC) transporter
HPG46_10080	COG0629	single-stranded DNA binding
HPG46_10085	COG1413	lyase activity
HPG46_10100	COG2521	methyltransferase
HPG46_10100	COG2136	Putative SAM-dependent methyltransferase
HPG46_10130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPG46_10150	COG0017	Asparaginyl-tRNA synthetase
HPG46_10170	COG1674	ftsk spoiiie
HPG46_10285	COG1929	Belongs to the glycerate kinase type-1 family
HPG46_10290	COG0471	metal ion transport
HPG46_10295	COG0745	RESPONSE REGULATOR receiver
HPG46_10300	COG5002	protein histidine kinase activity
HPG46_10300	COG3850	Histidine kinase
HPG46_10315	COG0733	neurotransmitter:sodium symporter activity
HPG46_10340	COG2610	gluconate transmembrane transporter activity
HPG46_10345	COG1454	alcohol dehydrogenase
HPG46_10350	COG1794	racemase activity, acting on amino acids and derivatives
HPG46_10360	COG0456	acetyltransferase
HPG46_10365	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPG46_10375	COG1131	(ABC) transporter
HPG46_10380	COG4473	ABC transporter
HPG46_10390	COG0546	phosphoglycolate phosphatase activity
HPG46_10410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_10415	COG3250	beta-galactosidase activity
HPG46_10430	COG0768	penicillin binding
HPG46_10440	COG0204	Acyl-transferase
HPG46_10445	COG1272	protein, Hemolysin III
HPG46_10455	COG0805	protein transport
HPG46_10465	COG1307	EDD domain protein, DegV family
HPG46_10470	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HPG46_10475	COG1999	signal sequence binding
HPG46_10480	COG0071	Belongs to the small heat shock protein (HSP20) family
HPG46_10485	COG0367	asparagine synthase
HPG46_10500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_10505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPG46_10525	COG1335	isochorismatase
HPG46_10530	COG1051	belongs to the nudix hydrolase family
HPG46_10535	COG0071	Belongs to the small heat shock protein (HSP20) family
HPG46_10540	COG0668	transmembrane transport
HPG46_10545	COG4585	Histidine kinase
HPG46_10545	COG2203	Gaf domain
HPG46_10550	COG2197	response regulator
HPG46_10560	COG1064	alcohol dehydrogenase
HPG46_10585	COG1070	Carbohydrate kinase
HPG46_10590	COG1070	Carbohydrate kinase
HPG46_10620	COG1125	glycine betaine transport
HPG46_10620	COG0517	IMP dehydrogenase activity
HPG46_10625	COG1174	glycine betaine transport
HPG46_10660	COG1253	flavin adenine dinucleotide binding
HPG46_10665	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_10670	COG5506	Protein of unknown function (DUF1694)
HPG46_10685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPG46_10690	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPG46_10695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPG46_10700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPG46_10705	COG0456	acetyltransferase
HPG46_10710	COG3829	transcription factor binding
HPG46_10715	COG1509	lysine 2,3-aminomutase activity
HPG46_10755	COG4326	sporulation control protein
HPG46_10760	COG0671	phosphoesterase, PA-phosphatase related
HPG46_10765	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPG46_10770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_10830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPG46_10865	COG0300	oxidoreductase activity
HPG46_10885	COG4499	WXG100 protein secretion system (Wss), protein YukC
HPG46_10885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_10890	COG2814	Major facilitator Superfamily
HPG46_10895	COG4841	protein insertion into membrane
HPG46_10900	COG0372	Belongs to the citrate synthase family
HPG46_10905	COG2079	MmgE PrpD family protein
HPG46_10910	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPG46_10915	COG1960	acyl-CoA dehydrogenase activity
HPG46_10920	COG2084	Dehydrogenase
HPG46_10930	COG1280	lysine exporter protein (LysE YggA)
HPG46_10935	COG1024	Enoyl-CoA hydratase
HPG46_10950	COG0420	3'-5' exonuclease activity
HPG46_10955	COG0419	ATPase involved in DNA repair
HPG46_10970	COG2223	nitrite transmembrane transporter activity
HPG46_10975	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_10980	COG1169	isochorismate synthase
HPG46_10985	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPG46_10990	COG1535	isochorismatase
HPG46_10990	COG3433	isochorismatase activity
HPG46_10995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPG46_11000	COG3251	PFAM MbtH domain protein
HPG46_11005	COG2814	Major facilitator Superfamily
HPG46_11020	COG0776	regulation of translation
HPG46_11030	COG2318	DinB family
HPG46_11040	COG1115	amino acid carrier protein
HPG46_11055	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_11060	COG1187	pseudouridine synthase activity
HPG46_11065	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPG46_11070	COG1136	(ABC) transporter
HPG46_11080	COG0596	Alpha beta hydrolase
HPG46_11085	COG2814	Major facilitator Superfamily
HPG46_11105	COG2226	methyltransferase
HPG46_11135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPG46_11150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_11185	COG1247	-acetyltransferase
HPG46_11215	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HPG46_11225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_11235	COG1278	Cold shock
HPG46_11250	COG0010	Belongs to the arginase family
HPG46_11255	COG0561	phosphatase activity
HPG46_11305	COG0583	DNA-binding transcription factor activity
HPG46_11310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPG46_11325	COG0583	DNA-binding transcription factor activity
HPG46_11330	COG2258	MOSC domain
HPG46_11345	COG1132	(ABC) transporter
HPG46_11350	COG1132	(ABC) transporter
HPG46_11370	COG1396	sequence-specific DNA binding
HPG46_11400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPG46_11410	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HPG46_11415	COG1595	DNA-templated transcription, initiation
HPG46_11440	COG1649	PFAM Uncharacterised BCR, COG1649
HPG46_11465	COG2971	BadF BadG BcrA BcrD
HPG46_11475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPG46_11500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_11530	COG1309	transcriptional regulator
HPG46_11545	COG0577	efflux transmembrane transporter activity
HPG46_11545	COG1136	(ABC) transporter
HPG46_11550	COG0500	methyltransferase
HPG46_11550	COG3615	Tellurite resistance protein tehB
HPG46_11560	COG3961	Belongs to the TPP enzyme family
HPG46_11565	COG1846	Transcriptional regulator
HPG46_11605	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPG46_11620	COG1595	DNA-templated transcription, initiation
HPG46_11630	COG0768	penicillin binding
HPG46_11635	COG0768	penicillin binding
HPG46_11640	COG2367	Beta-lactamase
HPG46_11645	COG0671	phosphoesterase, PA-phosphatase related
HPG46_11650	COG1609	Transcriptional regulator
HPG46_11655	COG2814	Major facilitator Superfamily
HPG46_11660	COG0673	inositol 2-dehydrogenase activity
HPG46_11685	COG0191	fructose-bisphosphate aldolase activity
HPG46_11690	COG3718	enzyme involved in inositol metabolism
HPG46_11700	COG0737	Belongs to the 5'-nucleotidase family
HPG46_11710	COG0457	Tetratricopeptide repeat
HPG46_11725	COG1876	peptidase activity
HPG46_11745	COG1309	transcriptional regulator
HPG46_11750	COG0488	(ABC) transporter
HPG46_11785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_11815	COG1252	NADH dehydrogenase
HPG46_11820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_11850	COG1960	acyl-CoA dehydrogenase activity
HPG46_11855	COG0439	Biotin carboxylase
HPG46_11860	COG0511	ligase activity, forming carbon-carbon bonds
HPG46_11865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPG46_11870	COG1024	Enoyl-CoA hydratase
HPG46_11875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPG46_11880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPG46_11890	COG1247	-acetyltransferase
HPG46_11895	COG0572	uridine kinase
HPG46_11905	COG1686	Belongs to the peptidase S11 family
HPG46_11930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPG46_11950	COG3227	Zinc metalloprotease (Elastase)
HPG46_11970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPG46_11995	COG2814	Major facilitator Superfamily
HPG46_12035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_12055	COG1063	alcohol dehydrogenase
HPG46_12075	COG3386	PFAM SMP-30 Gluconolaconase
HPG46_12085	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HPG46_12090	COG3773	Cell wall hydrolase
HPG46_12100	COG0745	RESPONSE REGULATOR receiver
HPG46_12105	COG2205	protein histidine kinase activity
HPG46_12115	COG0488	(ABC) transporter
HPG46_12130	COG1136	(ABC) transporter
HPG46_12135	COG0577	efflux transmembrane transporter activity
HPG46_12155	COG0460	homoserine dehydrogenase
HPG46_12160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_12170	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPG46_12195	COG0582	viral genome integration into host DNA
HPG46_12210	COG1396	sequence-specific DNA binding
HPG46_12240	COG1484	DNA-dependent DNA replication
HPG46_12325	COG0582	viral genome integration into host DNA
HPG46_12510	COG2124	cytochrome p450
HPG46_12545	COG0561	phosphatase activity
HPG46_12550	COG5002	protein histidine kinase activity
HPG46_12555	COG0768	penicillin binding
HPG46_12560	COG1819	glycosyl
HPG46_12565	COG1794	racemase activity, acting on amino acids and derivatives
HPG46_12575	COG1122	ATPase activity
HPG46_12590	COG2205	protein histidine kinase activity
HPG46_12600	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPG46_12605	COG0604	alcohol dehydrogenase
HPG46_12610	COG0671	phosphoesterase, PA-phosphatase related
HPG46_12615	COG0768	penicillin binding
HPG46_12625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_12680	COG2814	Major facilitator Superfamily
HPG46_12695	COG0584	glycerophosphoryl diester phosphodiesterase
HPG46_12710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_12715	COG0697	spore germination
HPG46_12745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_12755	COG2223	nitrite transmembrane transporter activity
HPG46_12770	COG2816	NAD+ diphosphatase activity
HPG46_12775	COG0592	DNA-directed DNA polymerase activity
HPG46_12780	COG1051	belongs to the nudix hydrolase family
HPG46_12810	COG3878	Protein conserved in bacteria
HPG46_12830	COG4667	esterase of the alpha-beta hydrolase superfamily
HPG46_12855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPG46_12870	COG0322	excinuclease ABC activity
HPG46_12910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_12935	COG1011	Hydrolase
HPG46_12955	COG1523	belongs to the glycosyl hydrolase 13 family
HPG46_12960	COG3227	Zinc metalloprotease (Elastase)
HPG46_12980	COG0201	protein transport
HPG46_12990	COG0697	spore germination
HPG46_12995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_13035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_13050	COG2959	enzyme of heme biosynthesis
HPG46_13075	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HPG46_13080	COG3844	kynureninase activity
HPG46_13085	COG1309	transcriptional regulator
HPG46_13115	COG3284	Transcriptional regulator
HPG46_13135	COG1349	DNA-binding transcription factor activity
HPG46_13155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPG46_13160	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPG46_13165	COG0022	dehydrogenase e1 component
HPG46_13170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPG46_13180	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_13185	COG0456	acetyltransferase
HPG46_13185	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPG46_13195	COG0494	nUDIX hydrolase
HPG46_13220	COG4176	ABC-type proline glycine betaine transport system permease component
HPG46_13225	COG4175	Glycine betaine
HPG46_13225	COG0517	IMP dehydrogenase activity
HPG46_13255	COG2153	protein acetylation
HPG46_13260	COG3397	chitin binding
HPG46_13275	COG2205	protein histidine kinase activity
HPG46_13280	COG2226	methyltransferase
HPG46_13295	COG0658	competence protein
HPG46_13295	COG2333	competence protein COMEC
HPG46_13345	COG3973	AAA domain
HPG46_13360	COG2105	PFAM AIG2 family protein
HPG46_13365	COG0514	ATP-dependent DNA helicase (RecQ)
HPG46_13395	COG4637	Psort location Cytoplasmic, score
HPG46_13415	COG3397	chitin binding
HPG46_13430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPG46_13435	COG1115	amino acid carrier protein
HPG46_13440	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_13445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPG46_13455	COG3938	Belongs to the proline racemase family
HPG46_13460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_13510	COG1078	dGTPase activity
HPG46_13515	COG0586	Pfam SNARE associated Golgi protein
HPG46_13530	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HPG46_13535	COG0519	Catalyzes the synthesis of GMP from XMP
HPG46_13540	COG4166	transmembrane transport
HPG46_13550	COG4948	Mandelate Racemase Muconate Lactonizing
HPG46_13590	COG2936	dipeptidyl-peptidase activity
HPG46_13595	COG5002	protein histidine kinase activity
HPG46_13600	COG0745	RESPONSE REGULATOR receiver
HPG46_13635	COG1164	Oligoendopeptidase f
HPG46_13650	COG1307	EDD domain protein, DegV family
HPG46_13685	COG2814	Major facilitator Superfamily
HPG46_13695	COG1664	Polymer-forming cytoskeletal
HPG46_13700	COG0789	Transcriptional regulator
HPG46_13705	COG4533	DNA binding
HPG46_13710	COG0477	Major facilitator Superfamily
HPG46_13710	COG2814	Major facilitator Superfamily
HPG46_13730	COG2261	transglycosylase associated protein
HPG46_13745	COG2226	methyltransferase
HPG46_13780	COG0436	Aminotransferase
HPG46_13785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPG46_13790	COG5146	pantothenate kinase activity
HPG46_13795	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HPG46_13855	COG0628	permease
HPG46_13865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPG46_13870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPG46_13875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPG46_13880	COG1116	anion transmembrane transporter activity
HPG46_13900	COG2816	NAD+ diphosphatase activity
HPG46_13920	COG2746	aminoglycoside 3-N-acetyltransferase activity
HPG46_13945	COG0697	spore germination
HPG46_13950	COG2318	DinB family
HPG46_13970	COG4912	Dna alkylation repair
HPG46_13990	COG0861	Integral membrane protein TerC family
HPG46_13995	COG1368	sulfuric ester hydrolase activity
HPG46_14000	COG0488	(ABC) transporter
HPG46_14010	COG1033	growth of symbiont in host cell
HPG46_14010	COG2409	Drug exporters of the RND superfamily
HPG46_14015	COG1309	transcriptional regulator
HPG46_14030	COG0287	Prephenate dehydrogenase
HPG46_14035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPG46_14045	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HPG46_14045	COG1605	Chorismate mutase
HPG46_14080	COG3584	3D domain protein
HPG46_14080	COG1388	LysM domain
HPG46_14090	COG1595	DNA-templated transcription, initiation
HPG46_14115	COG1879	ABC-type sugar transport system periplasmic component
HPG46_14125	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPG46_14135	COG2390	Transcriptional regulator
HPG46_14140	COG1070	Carbohydrate kinase
HPG46_14170	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_14190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_14200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPG46_14205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_14210	COG4187	Peptidase family M20/M25/M40
HPG46_14215	COG1414	Transcriptional regulator
HPG46_14220	COG0833	amino acid
HPG46_14230	COG3239	Fatty acid desaturase
HPG46_14235	COG1785	Belongs to the alkaline phosphatase family
HPG46_14245	COG3655	Transcriptional regulator
HPG46_14260	COG4377	Putative membrane peptidase family (DUF2324)
HPG46_14270	COG3279	Response regulator of the LytR AlgR family
HPG46_14280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_14285	COG0346	lactoylglutathione lyase activity
HPG46_14305	COG0714	Associated with various cellular activities
HPG46_14330	COG0463	Glycosyl transferase, family 2
HPG46_14350	COG0463	Glycosyl transferase, family 2
HPG46_14360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPG46_14365	COG0753	catalase activity
HPG46_14375	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HPG46_14400	COG0714	Associated with various cellular activities
HPG46_14410	COG0778	Nitroreductase
HPG46_14415	COG1846	Transcriptional regulator
HPG46_14435	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPG46_14455	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_14460	COG0183	Belongs to the thiolase family
HPG46_14465	COG1024	Enoyl-CoA hydratase
HPG46_14470	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPG46_14475	COG2723	6-phospho-beta-galactosidase activity
HPG46_14480	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPG46_14485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_14500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_14510	COG2508	Transcriptional regulator
HPG46_14515	COG2814	Major facilitator Superfamily
HPG46_14520	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HPG46_14550	COG1725	Transcriptional regulator
HPG46_14560	COG1136	(ABC) transporter
HPG46_14585	COG2207	Transcriptional regulator
HPG46_14590	COG0456	acetyltransferase
HPG46_14610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_14660	COG0730	response to heat
HPG46_14670	COG0833	amino acid
HPG46_14680	COG4335	DNA alkylation repair
HPG46_14710	COG0768	penicillin binding
HPG46_14740	COG1984	allophanate hydrolase subunit 2
HPG46_14745	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPG46_14750	COG1414	Transcriptional regulator
HPG46_14770	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_14775	COG0640	Transcriptional regulator
HPG46_14785	COG1960	acyl-CoA dehydrogenase activity
HPG46_14800	COG3314	Sporulation integral membrane protein YlbJ
HPG46_14830	COG3848	Pyruvate phosphate dikinase
HPG46_14830	COG0574	Belongs to the PEP-utilizing enzyme family
HPG46_14835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_14850	COG5577	PFAM Coat F domain
HPG46_14855	COG3403	YqcI/YcgG family
HPG46_14860	COG1280	lysine exporter protein (LysE YggA)
HPG46_14865	COG1113	amino acid transport
HPG46_14895	COG1063	alcohol dehydrogenase
HPG46_14905	COG1027	Aspartate ammonia-lyase
HPG46_14910	COG0252	asparaginase activity
HPG46_14915	COG1396	sequence-specific DNA binding
HPG46_14930	COG0531	amino acid
HPG46_14935	COG1114	Component of the transport system for branched-chain amino acids
HPG46_14940	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_14960	COG0784	Response regulator, receiver
HPG46_14965	COG4191	Histidine kinase
HPG46_14970	COG2066	Belongs to the glutaminase family
HPG46_14975	COG1115	amino acid carrier protein
HPG46_15015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_15015	COG0723	plastoquinol--plastocyanin reductase activity
HPG46_15020	COG0534	Mate efflux family protein
HPG46_15030	COG0531	amino acid
HPG46_15035	COG0737	Belongs to the 5'-nucleotidase family
HPG46_15035	COG1525	nuclease
HPG46_15035	COG4085	toxin activity
HPG46_15040	COG0753	catalase activity
HPG46_15045	COG2267	carboxylic ester hydrolase activity
HPG46_15050	COG1335	isochorismatase
HPG46_15070	COG0583	DNA-binding transcription factor activity
HPG46_15075	COG1846	Transcriptional regulator
HPG46_15080	COG0598	Magnesium transport protein CorA
HPG46_15120	COG0415	Belongs to the DNA photolyase family
HPG46_15125	COG0288	reversible hydration of carbon dioxide
HPG46_15135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPG46_15140	COG5609	conserved protein (DUF2294)
HPG46_15155	COG0714	Associated with various cellular activities
HPG46_15165	COG1575	Belongs to the MenA family. Type 1 subfamily
HPG46_15190	COG4641	Protein conserved in bacteria
HPG46_15220	COG0798	PFAM Bile acid sodium symporter
HPG46_15225	COG0346	lactoylglutathione lyase activity
HPG46_15230	COG0640	Transcriptional regulator
HPG46_15250	COG5002	protein histidine kinase activity
HPG46_15255	COG0745	RESPONSE REGULATOR receiver
HPG46_15260	COG0456	acetyltransferase
HPG46_15275	COG1309	transcriptional regulator
HPG46_15280	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_15300	COG0346	lactoylglutathione lyase activity
HPG46_15320	COG2169	Transcriptional regulator
HPG46_15365	COG2814	Major facilitator Superfamily
HPG46_15390	COG0745	RESPONSE REGULATOR receiver
HPG46_15395	COG3850	Histidine kinase
HPG46_15395	COG5002	protein histidine kinase activity
HPG46_15420	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HPG46_15445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_15450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPG46_15460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_15465	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HPG46_15485	COG0577	efflux transmembrane transporter activity
HPG46_15500	COG5002	protein histidine kinase activity
HPG46_15500	COG3850	Histidine kinase
HPG46_15510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_15515	COG2271	Major facilitator Superfamily
HPG46_15520	COG1556	Lactate utilization protein
HPG46_15525	COG1139	Iron-sulfur cluster binding protein
HPG46_15535	COG0583	DNA-binding transcription factor activity
HPG46_15555	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPG46_15570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPG46_15590	COG1595	DNA-templated transcription, initiation
HPG46_15605	COG0662	Cupin 2, conserved barrel domain protein
HPG46_15610	COG2207	Transcriptional regulator
HPG46_15610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_15625	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPG46_15625	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_15665	COG0477	Major facilitator Superfamily
HPG46_15675	COG1846	Transcriptional regulator
HPG46_15680	COG2814	Major facilitator Superfamily
HPG46_15690	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPG46_15695	COG1131	(ABC) transporter
HPG46_15715	COG2076	Multidrug Resistance protein
HPG46_15720	COG1309	transcriptional regulator
HPG46_15735	COG2031	fatty acid transporter
HPG46_15745	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPG46_15775	COG1122	ATPase activity
HPG46_15780	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPG46_15795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPG46_15800	COG1288	antiporter activity
HPG46_15805	COG2356	endonuclease I
HPG46_15820	COG3620	sequence-specific DNA binding
HPG46_15830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPG46_15850	COG1733	regulation of RNA biosynthetic process
HPG46_15855	COG0778	Nitroreductase
HPG46_15875	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_15885	COG1131	(ABC) transporter
HPG46_15910	COG1011	Hydrolase
HPG46_15920	COG2365	Tyrosine phosphatase family
HPG46_15945	COG0346	lactoylglutathione lyase activity
HPG46_15950	COG1940	carbohydrate kinase activity
HPG46_15955	COG0738	Major facilitator superfamily
HPG46_15960	COG0110	maltose O-acetyltransferase activity
HPG46_15975	COG0628	permease
HPG46_15995	COG2226	methyltransferase
HPG46_16005	COG0477	Major facilitator Superfamily
HPG46_16035	COG1253	flavin adenine dinucleotide binding
HPG46_16040	COG0789	Transcriptional regulator
HPG46_16050	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HPG46_16080	COG0697	spore germination
HPG46_16085	COG1357	PFAM Pentapeptide repeats (8 copies)
HPG46_16090	COG3813	Protein conserved in bacteria
HPG46_16095	COG2706	6-phosphogluconolactonase activity
HPG46_16100	COG1070	Carbohydrate kinase
HPG46_16110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HPG46_16115	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HPG46_16125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPG46_16130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPG46_16135	COG0604	alcohol dehydrogenase
HPG46_16140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPG46_16150	COG0604	alcohol dehydrogenase
HPG46_16150	COG3321	synthase
HPG46_16155	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_16175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPG46_16175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPG46_16180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPG46_16180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPG46_16185	COG1733	regulation of RNA biosynthetic process
HPG46_16200	COG0656	L-ascorbic acid biosynthetic process
HPG46_16205	COG2814	Major facilitator Superfamily
HPG46_16220	COG0346	lactoylglutathione lyase activity
HPG46_16225	COG0814	amino acid
HPG46_16255	COG1393	Belongs to the ArsC family
HPG46_16260	COG1733	regulation of RNA biosynthetic process
HPG46_16265	COG2188	Transcriptional regulator
HPG46_16270	COG0673	inositol 2-dehydrogenase activity
HPG46_16275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPG46_16280	COG1733	regulation of RNA biosynthetic process
HPG46_16285	COG1733	regulation of RNA biosynthetic process
HPG46_16305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_16325	COG0384	phenazine biosynthesis protein PhzF
HPG46_16335	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_16350	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_16355	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPG46_16360	COG1733	regulation of RNA biosynthetic process
HPG46_16380	COG1191	sigma factor activity
HPG46_16395	COG1309	transcriptional regulator
HPG46_16415	COG3152	Membrane
HPG46_16440	COG1151	hydroxylamine reductase activity
HPG46_16450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_16455	COG3757	hydrolase, family 25
HPG46_16455	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_16490	COG2072	flavoprotein involved in K transport
HPG46_16530	COG1113	amino acid transport
HPG46_16535	COG2814	Major facilitator Superfamily
HPG46_16565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPG46_16570	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPG46_16585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_16590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_16595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_16600	COG3739	integral membrane protein
HPG46_16605	COG0384	phenazine biosynthesis protein PhzF
HPG46_16635	COG0583	DNA-binding transcription factor activity
HPG46_16655	COG1193	negative regulation of DNA recombination
HPG46_16670	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HPG46_16675	COG1164	Oligoendopeptidase f
HPG46_16680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_16710	COG0584	glycerophosphoryl diester phosphodiesterase
HPG46_16735	COG0640	Transcriptional regulator
HPG46_16740	COG0604	alcohol dehydrogenase
HPG46_16750	COG0457	Tetratricopeptide repeat
HPG46_16760	COG0385	Bile acid
HPG46_16765	COG0277	FAD linked oxidase domain protein
HPG46_16800	COG1216	Glycosyl transferase, family 2
HPG46_16805	COG1024	Enoyl-CoA hydratase
HPG46_16815	COG1285	pathogenesis
HPG46_16830	COG2514	catechol 2,3-dioxygenase activity
HPG46_16835	COG2720	vancomycin resistance protein
HPG46_16875	COG0716	FMN binding
HPG46_16905	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_16915	COG0165	Argininosuccinate lyase
HPG46_16930	COG4145	pantothenate transmembrane transporter activity
HPG46_16940	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_16945	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_16955	COG1657	PFAM Prenyltransferase squalene oxidase
HPG46_16960	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HPG46_16965	COG2962	Rard protein
HPG46_16970	COG3326	Membrane
HPG46_16985	COG0489	protein tyrosine kinase activity
HPG46_16995	COG0314	molybdopterin synthase activity
HPG46_17000	COG0303	'Molybdopterin
HPG46_17005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPG46_17010	COG2116	formate transmembrane transporter activity
HPG46_17020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPG46_17025	COG5609	conserved protein (DUF2294)
HPG46_17030	COG2427	Protein of unknown function (DUF1641)
HPG46_17035	COG3383	formate dehydrogenase (NAD+) activity
HPG46_17040	COG0697	spore germination
HPG46_17080	COG2226	methyltransferase
HPG46_17085	COG4166	transmembrane transport
HPG46_17090	COG4166	transmembrane transport
HPG46_17095	COG4166	transmembrane transport
HPG46_17100	COG1301	dicarboxylic acid transport
HPG46_17105	COG1316	TRANSCRIPTIONal
HPG46_17115	COG1595	DNA-templated transcription, initiation
HPG46_17135	COG1131	(ABC) transporter
HPG46_17145	COG0673	inositol 2-dehydrogenase activity
HPG46_17150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPG46_17155	COG0187	DNA topoisomerase II activity
HPG46_17160	COG1832	CoA-binding protein
HPG46_17165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPG46_17170	COG0745	RESPONSE REGULATOR receiver
HPG46_17190	COG4841	protein insertion into membrane
HPG46_17195	COG0824	Thioesterase
HPG46_17225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_17235	COG1132	(ABC) transporter
HPG46_17240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPG46_17280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPG46_17295	COG0183	Belongs to the thiolase family
HPG46_17300	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_17305	COG1268	BioY protein
HPG46_17310	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_17360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_17370	COG5002	protein histidine kinase activity
HPG46_17375	COG0400	carboxylic ester hydrolase activity
HPG46_17380	COG0346	lactoylglutathione lyase activity
HPG46_17385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPG46_17390	COG0069	glutamate synthase activity
HPG46_17395	COG1902	pentaerythritol trinitrate reductase activity
HPG46_17400	COG1329	Transcriptional regulator
HPG46_17405	COG0010	Belongs to the arginase family
HPG46_17430	COG2226	methyltransferase
HPG46_17465	COG4846	Membrane protein involved in cytochrome C biogenesis
HPG46_17470	COG0785	Cytochrome C biogenesis protein
HPG46_17480	COG1473	amidohydrolase
HPG46_17490	COG1131	(ABC) transporter
HPG46_17500	COG0583	DNA-binding transcription factor activity
HPG46_17510	COG1346	cytolysis
HPG46_17525	COG0730	response to heat
HPG46_17535	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPG46_17535	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_17550	COG1132	(ABC) transporter
HPG46_17555	COG1132	(ABC) transporter
HPG46_17580	COG3639	organic phosphonate transmembrane transporter activity
HPG46_17595	COG0737	Belongs to the 5'-nucleotidase family
HPG46_17605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPG46_17625	COG1695	Transcriptional regulator
HPG46_17635	COG0174	glutamine synthetase
HPG46_17640	COG0789	Transcriptional regulator
HPG46_17645	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HPG46_17650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPG46_17655	COG2860	membrane
HPG46_17660	COG0464	growth
HPG46_17690	COG1388	LysM domain
HPG46_17690	COG3584	3D domain protein
HPG46_17695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPG46_17695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPG46_17695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPG46_17700	COG1105	Belongs to the carbohydrate kinase PfkB family
HPG46_17705	COG1349	DNA-binding transcription factor activity
HPG46_17710	COG1979	alcohol dehydrogenase
HPG46_17715	COG2322	membrane
HPG46_17725	COG1113	amino acid transport
HPG46_17740	COG1408	metallophosphoesterase
HPG46_17745	COG2116	formate transmembrane transporter activity
HPG46_17760	COG2217	Heavy metal translocating P-type atpase
HPG46_17765	COG2608	mercury ion transmembrane transporter activity
HPG46_17770	COG1937	Protein conserved in bacteria
HPG46_17780	COG2819	hydrolase of the alpha beta superfamily
HPG46_17785	COG1120	ATPase activity
HPG46_17790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_17795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_17800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_17805	COG0708	Exodeoxyribonuclease III
HPG46_17815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPG46_17820	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPG46_17830	COG2364	Membrane
HPG46_17845	COG2267	carboxylic ester hydrolase activity
HPG46_17850	COG0346	lactoylglutathione lyase activity
HPG46_17855	COG3300	MHYT domain
HPG46_17855	COG5001	Diguanylate cyclase
HPG46_17870	COG1346	cytolysis
HPG46_17875	COG1380	Effector of murein hydrolase LrgA
HPG46_17880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_17890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPG46_17910	COG1404	Belongs to the peptidase S8 family
HPG46_17915	COG3773	Cell wall hydrolase
HPG46_17920	COG0562	UDP-galactopyranose mutase
HPG46_17925	COG1368	sulfuric ester hydrolase activity
HPG46_17930	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPG46_17940	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HPG46_17960	COG4550	Control of competence regulator ComK, YlbF/YmcA
HPG46_17970	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPG46_17975	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPG46_17975	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPG46_17985	COG2359	stage V sporulation protein S
HPG46_17990	COG1692	metallophosphoesterase
HPG46_18015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPG46_18020	COG1426	Protein conserved in bacteria
HPG46_18035	COG0300	oxidoreductase activity
HPG46_18040	COG0612	Peptidase, M16
HPG46_18045	COG0612	Peptidase, M16
HPG46_18050	COG1079	Belongs to the binding-protein-dependent transport system permease family
HPG46_18055	COG4603	Belongs to the binding-protein-dependent transport system permease family
HPG46_18060	COG3845	ABC transporter
HPG46_18065	COG1744	ABC transporter substrate-binding protein PnrA-like
HPG46_18070	COG2188	Transcriptional regulator
HPG46_18080	COG1674	ftsk spoiiie
HPG46_18090	COG0740	serine-type endopeptidase activity
HPG46_18095	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPG46_18105	COG0527	aspartate kinase activity
HPG46_18110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPG46_18115	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPG46_18120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPG46_18125	COG1873	PFAM PRC-barrel domain
HPG46_18130	COG0612	Peptidase, M16
HPG46_18135	COG0726	polysaccharide deacetylase
HPG46_18150	COG0196	riboflavin kinase activity
HPG46_18155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HPG46_18165	COG1550	Protein conserved in bacteria
HPG46_18175	COG1358	cellular component organization or biogenesis
HPG46_18180	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HPG46_18185	COG0195	Participates in both transcription termination and antitermination
HPG46_18205	COG0750	zinc metalloprotease
HPG46_18215	COG4589	Belongs to the CDS family
HPG46_18230	COG0528	UMP kinase activity
HPG46_18260	COG4974	Belongs to the 'phage' integrase family
HPG46_18270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPG46_18275	COG0758	DNA mediated transformation
HPG46_18280	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPG46_18320	COG1837	Belongs to the UPF0109 family
HPG46_18330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPG46_18340	COG0552	protein localization to endoplasmic reticulum
HPG46_18345	COG1196	nuclear chromosome segregation
HPG46_18355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPG46_18360	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_18365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPG46_18380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPG46_18385	COG1461	Dihydroxyacetone kinase
HPG46_18390	COG1302	Protein conserved in bacteria
HPG46_18405	COG1564	THIamine pyrophosphokinase
HPG46_18410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPG46_18415	COG1162	GTPase activity
HPG46_18420	COG0515	serine threonine protein kinase
HPG46_18420	COG2815	serine threonine protein kinase
HPG46_18425	COG0631	protein serine/threonine phosphatase activity
HPG46_18435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPG46_18435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPG46_18445	COG0242	peptide deformylase activity
HPG46_18450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPG46_18455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPG46_18475	COG1561	YicC-like family, N-terminal region
HPG46_18480	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPG46_18490	COG0006	proline dipeptidase activity
HPG46_18510	COG3069	C4-dicarboxylate transmembrane transporter activity
HPG46_18520	COG1011	Hydrolase
HPG46_18575	COG0564	pseudouridine synthase activity
HPG46_18595	COG3599	regulation of cell shape
HPG46_18600	COG2302	S4 RNA-binding domain
HPG46_18605	COG0762	integral membrane protein
HPG46_18615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPG46_18620	COG1496	oxidoreductase activity
HPG46_18625	COG1873	PFAM PRC-barrel domain
HPG46_18630	COG1191	sigma factor activity
HPG46_18635	COG1191	sigma factor activity
HPG46_18645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPG46_18650	COG0849	cell division
HPG46_18655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPG46_18660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPG46_18670	COG0772	Belongs to the SEDS family
HPG46_18685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPG46_18690	COG0768	penicillin binding
HPG46_18695	COG0768	penicillin binding
HPG46_18700	COG4839	cell division protein FtsL
HPG46_18715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPG46_18730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPG46_18735	COG1399	metal-binding, possibly nucleic acid-binding protein
HPG46_18745	COG3480	Lon protease (S16) C-terminal proteolytic domain
HPG46_18750	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPG46_18755	COG3314	Sporulation integral membrane protein YlbJ
HPG46_18765	COG0742	ribosomal rna small subunit methyltransferase
HPG46_18780	COG3679	Belongs to the UPF0342 family
HPG46_18785	COG0406	alpha-ribazole phosphatase activity
HPG46_18800	COG2340	Cysteine-rich secretory protein family
HPG46_18815	COG3336	cytochrome c oxidase
HPG46_18850	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HPG46_18855	COG0772	Belongs to the SEDS family
HPG46_18865	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPG46_18870	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPG46_18880	COG4896	Protein conserved in bacteria
HPG46_18895	COG1217	gtp-binding protein TYPA
HPG46_18905	COG0483	inositol monophosphate 1-phosphatase activity
HPG46_18925	COG1982	Orn Lys Arg decarboxylase major
HPG46_18975	COG0022	dehydrogenase e1 component
HPG46_18980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPG46_18990	COG0242	peptide deformylase activity
HPG46_18995	COG0561	phosphatase activity
HPG46_19005	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPG46_19010	COG0569	domain protein
HPG46_19030	COG0583	DNA-binding transcription factor activity
HPG46_19035	COG0517	IMP dehydrogenase activity
HPG46_19045	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HPG46_19055	COG4703	Protein of unknown function (DUF1797)
HPG46_19070	COG2200	EAL domain
HPG46_19075	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_19080	COG1408	metallophosphoesterase
HPG46_19090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPG46_19125	COG2814	Major facilitator Superfamily
HPG46_19145	COG3209	COG3209 Rhs family protein
HPG46_19155	COG2205	protein histidine kinase activity
HPG46_19165	COG0436	Aminotransferase
HPG46_19170	COG1609	Transcriptional regulator
HPG46_19175	COG3833	ABC-type maltose transport systems, permease component
HPG46_19180	COG1175	transmembrane transport
HPG46_19185	COG2182	Extracellular solute-binding protein
HPG46_19195	COG0366	Alpha amylase catalytic
HPG46_19200	COG3842	ATPase activity
HPG46_19240	COG0183	Belongs to the thiolase family
HPG46_19280	COG1695	Transcriptional regulator
HPG46_19285	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_19295	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HPG46_19305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPG46_19310	COG0436	Aminotransferase
HPG46_19345	COG2084	Dehydrogenase
HPG46_19350	COG2199	diguanylate cyclase activity
HPG46_19355	COG0778	Nitroreductase
HPG46_19380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_19380	COG2190	(PTS) system
HPG46_19380	COG1263	PTS System
HPG46_19385	COG3711	transcriptional antiterminator
HPG46_19395	COG2188	Transcriptional regulator
HPG46_19405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPG46_19430	COG1547	Domain of unknown function (DUF309)
HPG46_19435	COG0456	acetyltransferase
HPG46_19440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPG46_19445	COG4086	secreted protein
HPG46_19450	COG0561	phosphatase activity
HPG46_19455	COG0697	spore germination
HPG46_19470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_19495	COG0733	neurotransmitter:sodium symporter activity
HPG46_19515	COG1686	Belongs to the peptidase S11 family
HPG46_19520	COG1725	Transcriptional regulator
HPG46_19525	COG1131	(ABC) transporter
HPG46_19540	COG1846	Transcriptional regulator
HPG46_19555	COG0598	Magnesium transport protein CorA
HPG46_19580	COG4974	Belongs to the 'phage' integrase family
HPG46_19590	COG0735	belongs to the Fur family
HPG46_19595	COG1300	Membrane
HPG46_19615	COG0667	Aldo Keto reductase
HPG46_19620	COG0656	L-ascorbic acid biosynthetic process
HPG46_19625	COG0456	acetyltransferase
HPG46_19625	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPG46_19635	COG4085	toxin activity
HPG46_19635	COG1525	nuclease
HPG46_19635	COG0737	Belongs to the 5'-nucleotidase family
HPG46_19645	COG0596	Alpha beta hydrolase
HPG46_19650	COG2056	Na+-H+ antiporter family
HPG46_19655	COG1609	Transcriptional regulator
HPG46_19660	COG0456	acetyltransferase
HPG46_19665	COG1073	alpha beta
HPG46_19680	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPG46_19680	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPG46_19685	COG0307	riboflavin synthase, alpha
HPG46_19710	COG4106	trans-aconitate 2-methyltransferase activity
HPG46_19715	COG2226	methyltransferase
HPG46_19715	COG1073	alpha beta
HPG46_19730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPG46_19740	COG1757	Na H antiporter
HPG46_19745	COG0737	Belongs to the 5'-nucleotidase family
HPG46_19755	COG1522	sequence-specific DNA binding
HPG46_19775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPG46_19785	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HPG46_19800	COG0300	oxidoreductase activity
HPG46_19805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_19810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_19815	COG1760	l-serine dehydratase
HPG46_19820	COG1760	l-serine dehydratase
HPG46_19845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPG46_19855	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPG46_19860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_19875	COG1376	ErfK ybiS ycfS ynhG family protein
HPG46_19880	COG4129	membrane
HPG46_19885	COG1126	abc transporter atp-binding protein
HPG46_19890	COG0765	amino acid transport
HPG46_19895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_19910	COG2816	NAD+ diphosphatase activity
HPG46_19915	COG0772	Belongs to the SEDS family
HPG46_19920	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPG46_19925	COG0022	dehydrogenase e1 component
HPG46_19930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPG46_19935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPG46_19950	COG0280	phosphate acetyltransferase
HPG46_19955	COG3290	protein histidine kinase activity
HPG46_19955	COG3829	transcription factor binding
HPG46_19965	COG0584	glycerophosphoryl diester phosphodiesterase
HPG46_19970	COG3093	addiction module antidote protein HigA
HPG46_19980	COG0745	RESPONSE REGULATOR receiver
HPG46_19985	COG0750	zinc metalloprotease
HPG46_19990	COG0497	DNA recombination
HPG46_20000	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HPG46_20010	COG0142	geranyltranstransferase activity
HPG46_20035	COG1302	Protein conserved in bacteria
HPG46_20040	COG0439	Biotin carboxylase
HPG46_20045	COG0511	ligase activity, forming carbon-carbon bonds
HPG46_20090	COG3854	ATPases associated with a variety of cellular activities
HPG46_20115	COG0006	proline dipeptidase activity
HPG46_20130	COG3872	metal-dependent enzyme
HPG46_20140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPG46_20170	COG0095	Lipoate-protein ligase
HPG46_20175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_20180	COG1609	Transcriptional regulator
HPG46_20190	COG2076	Multidrug Resistance protein
HPG46_20195	COG2076	Multidrug Resistance protein
HPG46_20230	COG1131	(ABC) transporter
HPG46_20235	COG1725	Transcriptional regulator
HPG46_20265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPG46_20320	COG4970	Tfp pilus assembly protein FimT
HPG46_20330	COG1459	type II secretion system
HPG46_20335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPG46_20380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPG46_20385	COG1410	methionine synthase
HPG46_20385	COG0646	methionine synthase
HPG46_20390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPG46_20390	COG0646	methionine synthase
HPG46_20395	COG0626	cystathionine gamma-synthase activity
HPG46_20400	COG0626	cystathionine gamma-synthase activity
HPG46_20420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_20430	COG1940	carbohydrate kinase activity
HPG46_20435	COG4483	Protein conserved in bacteria
HPG46_20440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPG46_20445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPG46_20450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HPG46_20455	COG0704	Plays a role in the regulation of phosphate uptake
HPG46_20465	COG0581	inorganic phosphate transmembrane transporter activity
HPG46_20470	COG0573	inorganic phosphate transmembrane transporter activity
HPG46_20475	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPG46_20480	COG0768	penicillin binding
HPG46_20485	COG0477	Major facilitator Superfamily
HPG46_20490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPG46_20515	COG0735	belongs to the Fur family
HPG46_20520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPG46_20525	COG1121	(ABC) transporter
HPG46_20530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_20560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPG46_20565	COG2384	SAM-dependent methyltransferase
HPG46_20570	COG2010	Cytochrome c
HPG46_20575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPG46_20580	COG0358	DNA primase activity
HPG46_20590	COG0517	IMP dehydrogenase activity
HPG46_20605	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPG46_20610	COG0295	cytidine deaminase activity
HPG46_20615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPG46_20625	COG1480	7TM receptor with intracellular HD hydrolase
HPG46_20630	COG1702	phosphate starvation-inducible protein PhoH
HPG46_20645	COG1610	YqeY-like protein
HPG46_20650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPG46_20655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPG46_20660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPG46_20690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPG46_20695	COG1733	regulation of RNA biosynthetic process
HPG46_20720	COG1466	dna polymerase III delta subunit
HPG46_20730	COG0658	competence protein
HPG46_20730	COG2333	competence protein COMEC
HPG46_20735	COG2131	deaminase
HPG46_20740	COG1555	photosystem II stabilization
HPG46_20740	COG1596	polysaccharide export
HPG46_20745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_20750	COG2226	methyltransferase
HPG46_20755	COG0799	negative regulation of ribosome biogenesis
HPG46_20760	COG1713	HD superfamily hydrolase involved in NAD metabolism
HPG46_20770	COG1534	Rna-binding protein
HPG46_20780	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HPG46_20785	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HPG46_20810	COG1595	DNA-templated transcription, initiation
HPG46_20820	COG0778	Nitroreductase
HPG46_20825	COG2357	RelA SpoT domain protein
HPG46_20835	COG1785	Belongs to the alkaline phosphatase family
HPG46_20845	COG2267	carboxylic ester hydrolase activity
HPG46_20880	COG1404	Belongs to the peptidase S8 family
HPG46_20885	COG3186	Phenylalanine-4-hydroxylase
HPG46_20895	COG2514	catechol 2,3-dioxygenase activity
HPG46_20900	COG2259	Doxx family
HPG46_20940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_20950	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_20950	COG1454	alcohol dehydrogenase
HPG46_20955	COG0626	cystathionine gamma-synthase activity
HPG46_20960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPG46_20985	COG0768	penicillin binding
HPG46_21000	COG0826	peptidase U32
HPG46_21005	COG0826	peptidase U32
HPG46_21010	COG4122	O-methyltransferase activity
HPG46_21015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPG46_21045	COG0628	permease
HPG46_21065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPG46_21080	COG1104	cysteine desulfurase activity
HPG46_21085	COG1959	2 iron, 2 sulfur cluster binding
HPG46_21090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPG46_21100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPG46_21130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPG46_21140	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPG46_21140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPG46_21145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPG46_21150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPG46_21150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPG46_21160	COG2244	polysaccharide biosynthetic process
HPG46_21165	COG2323	membrane
HPG46_21175	COG1862	Preprotein translocase
HPG46_21205	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HPG46_21215	COG0697	spore germination
HPG46_21220	COG0640	Transcriptional regulator
HPG46_21245	COG0157	Belongs to the NadC ModD family
HPG46_21250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPG46_21255	COG1104	cysteine desulfurase activity
HPG46_21260	COG1827	regulation of RNA biosynthetic process
HPG46_21265	COG2258	MOSC domain
HPG46_21270	COG0077	Prephenate dehydratase
HPG46_21275	COG0577	efflux transmembrane transporter activity
HPG46_21280	COG0577	efflux transmembrane transporter activity
HPG46_21285	COG1136	(ABC) transporter
HPG46_21290	COG5002	protein histidine kinase activity
HPG46_21295	COG0745	RESPONSE REGULATOR receiver
HPG46_21305	COG3290	protein histidine kinase activity
HPG46_21315	COG2868	ribosomal protein
HPG46_21325	COG1530	ribonuclease E activity
HPG46_21330	COG1994	Peptidase M50
HPG46_21335	COG0739	heme binding
HPG46_21340	COG2894	cell division
HPG46_21360	COG1077	Cell shape determining protein MreB Mrl
HPG46_21380	COG0285	dihydrofolate synthase activity
HPG46_21385	COG0525	valine-tRNA ligase activity
HPG46_21395	COG1388	LysM domain
HPG46_21405	COG0113	porphobilinogen synthase activity
HPG46_21410	COG1587	Uroporphyrinogen-III synthase
HPG46_21420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPG46_21430	COG1846	Transcriptional regulator
HPG46_21435	COG1764	response to oxidative stress
HPG46_21450	COG0470	DNA polymerase III
HPG46_21450	COG1067	ATP-dependent peptidase activity
HPG46_21500	COG0622	Phosphoesterase
HPG46_21515	COG5401	PFAM Sporulation and spore germination
HPG46_21535	COG1309	transcriptional regulator
HPG46_21550	COG2197	response regulator
HPG46_21555	COG2233	PERMEase
HPG46_21565	COG0402	S-adenosylhomocysteine deaminase activity
HPG46_21570	COG0402	S-adenosylhomocysteine deaminase activity
HPG46_21580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPG46_21590	COG0444	Belongs to the ABC transporter superfamily
HPG46_21595	COG4608	Belongs to the ABC transporter superfamily
HPG46_21600	COG3275	phosphorelay sensor kinase activity
HPG46_21605	COG3279	Response regulator of the LytR AlgR family
HPG46_21615	COG1983	PspC domain protein
HPG46_21620	COG1396	sequence-specific DNA binding
HPG46_21625	COG0697	spore germination
HPG46_21635	COG1959	2 iron, 2 sulfur cluster binding
HPG46_21640	COG1668	transmembrane transport
HPG46_21645	COG4152	abc transporter atp-binding protein
HPG46_21650	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HPG46_21655	COG1360	Flagellar Motor Protein
HPG46_21660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPG46_21665	COG1876	peptidase activity
HPG46_21670	COG0824	Thioesterase
HPG46_21675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPG46_21680	COG1053	succinate dehydrogenase
HPG46_21685	COG2009	succinate dehydrogenase
HPG46_21690	COG1719	4-vinyl reductase, 4VR
HPG46_21700	COG3118	belongs to the thioredoxin family
HPG46_21705	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPG46_21710	COG2086	electron transfer activity
HPG46_21715	COG1024	Enoyl-CoA hydratase
HPG46_21720	COG1309	transcriptional regulator
HPG46_21725	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_21745	COG2318	DinB family
HPG46_21765	COG1131	(ABC) transporter
HPG46_21770	COG2205	protein histidine kinase activity
HPG46_21775	COG0745	RESPONSE REGULATOR receiver
HPG46_21785	COG4895	conserved protein (DUF2196)
HPG46_21790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPG46_21805	COG4509	Sortase family
HPG46_21810	COG1120	ATPase activity
HPG46_21825	COG5386	Cell surface protein
HPG46_21830	COG5386	Cell surface protein
HPG46_21835	COG1114	Component of the transport system for branched-chain amino acids
HPG46_21840	COG1187	pseudouridine synthase activity
HPG46_21850	COG1796	DNA polymerase
HPG46_21850	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPG46_21855	COG1286	toxin biosynthetic process
HPG46_21900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPG46_21910	COG1418	mRNA catabolic process
HPG46_21920	COG2814	Major facilitator Superfamily
HPG46_21925	COG1566	PFAM secretion protein HlyD family protein
HPG46_21930	COG1309	transcriptional regulator
HPG46_21935	COG1363	Peptidase, m42
HPG46_21960	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPG46_21970	COG1484	DNA-dependent DNA replication
HPG46_21975	COG3611	Membrane attachment protein
HPG46_21985	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HPG46_21990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPG46_21995	COG0237	dephospho-CoA kinase activity
HPG46_22000	COG1971	Probably functions as a manganese efflux pump
HPG46_22010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPG46_22010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPG46_22015	COG5002	protein histidine kinase activity
HPG46_22020	COG0745	RESPONSE REGULATOR receiver
HPG46_22040	COG0538	isocitrate dehydrogenase activity
HPG46_22045	COG0372	Belongs to the citrate synthase family
HPG46_22055	COG0628	permease
HPG46_22060	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPG46_22085	COG1725	Transcriptional regulator
HPG46_22090	COG0281	malic enzyme
HPG46_22095	COG0587	DNA-directed DNA polymerase activity
HPG46_22110	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPG46_22130	COG4109	DRTGG domain
HPG46_22145	COG0006	proline dipeptidase activity
HPG46_22185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_22190	COG0662	Cupin 2, conserved barrel domain protein
HPG46_22200	COG1476	TRANSCRIPTIONal
HPG46_22215	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_22220	COG0589	response to stress
HPG46_22260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_22280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPG46_22285	COG0827	DNA restriction-modification system
HPG46_22290	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPG46_22295	COG3874	Sporulation protein YtfJ
HPG46_22310	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HPG46_22320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPG46_22335	COG1104	cysteine desulfurase activity
HPG46_22345	COG0583	DNA-binding transcription factor activity
HPG46_22350	COG0697	spore germination
HPG46_22355	COG1309	transcriptional regulator
HPG46_22360	COG1956	GAF domain-containing protein
HPG46_22365	COG0626	cystathionine gamma-synthase activity
HPG46_22420	COG1595	DNA-templated transcription, initiation
HPG46_22430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPG46_22435	COG0454	-acetyltransferase
HPG46_22440	COG0517	IMP dehydrogenase activity
HPG46_22445	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPG46_22460	COG0745	RESPONSE REGULATOR receiver
HPG46_22465	COG5002	protein histidine kinase activity
HPG46_22470	COG0666	response to abiotic stimulus
HPG46_22505	COG1609	Transcriptional regulator
HPG46_22510	COG4851	CamS sex pheromone cAM373 precursor
HPG46_22515	COG3118	belongs to the thioredoxin family
HPG46_22525	COG2309	aminopeptidase activity
HPG46_22545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_22550	COG1695	Transcriptional regulator
HPG46_22570	COG1674	ftsk spoiiie
HPG46_22580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPG46_22590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_22595	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HPG46_22600	COG1363	Peptidase, m42
HPG46_22610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_22625	COG0510	thiamine kinase activity
HPG46_22630	COG1523	belongs to the glycosyl hydrolase 13 family
HPG46_22640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPG46_22645	COG1349	DNA-binding transcription factor activity
HPG46_22650	COG1187	pseudouridine synthase activity
HPG46_22655	COG2244	polysaccharide biosynthetic process
HPG46_22660	COG2081	HI0933 family
HPG46_22665	COG2814	Major facilitator Superfamily
HPG46_22675	COG3832	glyoxalase III activity
HPG46_22695	COG1329	Transcriptional regulator
HPG46_22720	COG0314	molybdopterin synthase activity
HPG46_22725	COG1763	Mo-molybdopterin cofactor biosynthetic process
HPG46_22730	COG0303	'Molybdopterin
HPG46_22740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPG46_22745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPG46_22765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_22775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPG46_22815	COG2814	Major facilitator Superfamily
HPG46_22820	COG0475	glutathione-regulated potassium exporter activity
HPG46_22825	COG0490	domain, Protein
HPG46_22830	COG0582	viral genome integration into host DNA
HPG46_22840	COG1136	(ABC) transporter
HPG46_22860	COG1242	4 iron, 4 sulfur cluster binding
HPG46_22865	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HPG46_22880	COG1794	racemase activity, acting on amino acids and derivatives
HPG46_22890	COG5504	Zn-dependent protease
HPG46_22915	COG2267	carboxylic ester hydrolase activity
HPG46_22920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPG46_22925	COG0671	phosphoesterase, PA-phosphatase related
HPG46_22930	COG0438	transferase activity, transferring glycosyl groups
HPG46_22940	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPG46_22995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPG46_23000	COG5002	protein histidine kinase activity
HPG46_23005	COG4191	Histidine kinase
HPG46_23010	COG2267	carboxylic ester hydrolase activity
HPG46_23015	COG1368	sulfuric ester hydrolase activity
HPG46_23030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPG46_23035	COG1116	anion transmembrane transporter activity
HPG46_23040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPG46_23055	COG0546	phosphoglycolate phosphatase activity
HPG46_23065	COG0494	nUDIX hydrolase
HPG46_23100	COG0288	reversible hydration of carbon dioxide
HPG46_23105	COG1271	oxidase subunit
HPG46_23110	COG1294	oxidase, subunit
HPG46_23130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_23155	COG1842	Phage shock protein A
HPG46_23200	COG5002	protein histidine kinase activity
HPG46_23205	COG0745	RESPONSE REGULATOR receiver
HPG46_23230	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HPG46_23235	COG1597	lipid kinase activity
HPG46_23250	COG0577	efflux transmembrane transporter activity
HPG46_23255	COG1136	(ABC) transporter
HPG46_23270	COG0586	Pfam SNARE associated Golgi protein
HPG46_23280	COG4977	sequence-specific DNA binding
HPG46_23290	COG0577	efflux transmembrane transporter activity
HPG46_23295	COG1136	(ABC) transporter
HPG46_23300	COG3708	Transcriptional regulator
HPG46_23300	COG2207	Transcriptional regulator
HPG46_23310	COG5658	integral membrane protein
HPG46_23320	COG0745	RESPONSE REGULATOR receiver
HPG46_23325	COG2205	protein histidine kinase activity
HPG46_23330	COG0577	efflux transmembrane transporter activity
HPG46_23335	COG0577	efflux transmembrane transporter activity
HPG46_23340	COG1136	(ABC) transporter
HPG46_23345	COG0577	efflux transmembrane transporter activity
HPG46_23360	COG2188	Transcriptional regulator
HPG46_23380	COG3964	amidohydrolase
HPG46_23400	COG4948	Mandelate Racemase Muconate Lactonizing
HPG46_23410	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPG46_23415	COG0596	Alpha beta hydrolase
HPG46_23420	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPG46_23425	COG1169	isochorismate synthase
HPG46_23430	COG1575	Belongs to the MenA family. Type 1 subfamily
HPG46_23435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPG46_23455	COG0058	SHG alpha-glucan phosphorylase activity
HPG46_23465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPG46_23485	COG1404	Belongs to the peptidase S8 family
HPG46_23585	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPG46_23620	COG1285	pathogenesis
HPG46_23625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPG46_23640	COG2155	Conserved Protein
HPG46_23645	COG1098	S1 RNA binding domain
HPG46_23650	COG0436	Aminotransferase
HPG46_23655	COG1522	sequence-specific DNA binding
HPG46_23660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPG46_23665	COG2267	carboxylic ester hydrolase activity
HPG46_23675	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPG46_23695	COG5018	Exonuclease
HPG46_23700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPG46_23720	COG2050	protein possibly involved in aromatic compounds catabolism
HPG46_23730	COG1268	BioY protein
HPG46_23735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPG46_23740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPG46_23755	COG3584	3D domain protein
HPG46_23770	COG1252	NADH dehydrogenase
HPG46_23785	COG3708	Transcriptional regulator
HPG46_23800	COG1683	Conserved Protein
HPG46_23820	COG0316	Belongs to the HesB IscA family
HPG46_23835	COG1252	NADH dehydrogenase
HPG46_23850	COG0390	transport system, permease component
HPG46_23855	COG2824	Alkylphosphonate utilization operon protein PhnA
HPG46_23875	COG4837	Protein of unknown function (DUF1462)
HPG46_23880	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HPG46_23890	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPG46_23895	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPG46_23910	COG0577	efflux transmembrane transporter activity
HPG46_23910	COG1136	(ABC) transporter
HPG46_23915	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPG46_23925	COG0647	UMP catabolic process
HPG46_23935	COG2445	Protein of unknown function DUF86
HPG46_23940	COG1494	fructose-1,6-bisphosphatase
HPG46_23955	COG4470	Protein conserved in bacteria
HPG46_23965	COG0789	Transcriptional regulator
HPG46_23970	COG4377	Putative membrane peptidase family (DUF2324)
HPG46_23995	COG0739	heme binding
HPG46_24005	COG3377	Domain of unknown function (DUF1805)
HPG46_24010	COG0737	Belongs to the 5'-nucleotidase family
HPG46_24015	COG1695	Transcriptional regulator
HPG46_24025	COG0719	Fe-S assembly protein
HPG46_24030	COG0822	iron-sulfur transferase activity
HPG46_24035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPG46_24040	COG0719	Fe-S assembly protein
HPG46_24045	COG0396	ATPase activity
HPG46_24050	COG1464	Belongs to the NlpA lipoprotein family
HPG46_24055	COG1464	Belongs to the NlpA lipoprotein family
HPG46_24060	COG2011	ABC-type metal ion transport system permease component
HPG46_24075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_24080	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HPG46_24090	COG1393	Belongs to the ArsC family
HPG46_24155	COG1309	transcriptional regulator
HPG46_24160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_24165	COG1960	acyl-CoA dehydrogenase activity
HPG46_24170	COG0183	Belongs to the thiolase family
HPG46_24175	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPG46_24175	COG1024	Enoyl-CoA hydratase
HPG46_24185	COG1686	Belongs to the peptidase S11 family
HPG46_24200	COG0011	TIGRFAM Protein of
HPG46_24205	COG0840	transmembrane signaling receptor activity
HPG46_24225	COG2814	Major facilitator Superfamily
HPG46_24230	COG0531	amino acid
HPG46_24240	COG0706	membrane insertase activity
HPG46_24250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_24290	COG0586	Pfam SNARE associated Golgi protein
HPG46_24300	COG1376	ErfK ybiS ycfS ynhG family protein
HPG46_24305	COG0745	RESPONSE REGULATOR receiver
HPG46_24310	COG5002	protein histidine kinase activity
HPG46_24335	COG0840	transmembrane signaling receptor activity
HPG46_24340	COG2151	metal-sulfur cluster biosynthetic enzyme
HPG46_24345	COG3227	Zinc metalloprotease (Elastase)
HPG46_24350	COG1741	Belongs to the pirin family
HPG46_24365	COG0475	glutathione-regulated potassium exporter activity
HPG46_24370	COG0490	domain, Protein
HPG46_24375	COG1115	amino acid carrier protein
HPG46_24380	COG0783	Belongs to the Dps family
HPG46_24395	COG1611	Belongs to the LOG family
HPG46_24415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_24420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_24425	COG1115	amino acid carrier protein
HPG46_24430	COG1115	amino acid carrier protein
HPG46_24435	COG2910	NAD(P)H-binding
HPG46_24455	COG0656	L-ascorbic acid biosynthetic process
HPG46_24460	COG2814	Major facilitator Superfamily
HPG46_24465	COG1733	regulation of RNA biosynthetic process
HPG46_24475	COG1252	NADH dehydrogenase
HPG46_24480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPG46_24485	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPG46_24495	COG3290	protein histidine kinase activity
HPG46_24495	COG0840	transmembrane signaling receptor activity
HPG46_24525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_24585	COG0557	exoribonuclease II activity
HPG46_24590	COG1647	Serine aminopeptidase, S33
HPG46_24595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPG46_24600	COG1346	cytolysis
HPG46_24635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPG46_24650	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPG46_24670	COG0457	Tetratricopeptide repeat
HPG46_24700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_24715	COG2323	membrane
HPG46_24725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPG46_24735	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPG46_24745	COG1051	belongs to the nudix hydrolase family
HPG46_24755	COG0492	ferredoxin-NADP+ reductase activity
HPG46_24760	COG0457	Tetratricopeptide repeat
HPG46_24765	COG0110	maltose O-acetyltransferase activity
HPG46_24785	COG1950	PFAM Membrane protein of
HPG46_24795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPG46_24815	COG0789	Transcriptional regulator
HPG46_24845	COG2855	membrane
HPG46_24850	COG0583	DNA-binding transcription factor activity
HPG46_24860	COG0655	NAD(P)H dehydrogenase (quinone) activity
HPG46_24875	COG1132	(ABC) transporter
HPG46_24885	COG0583	DNA-binding transcription factor activity
HPG46_24890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPG46_24895	COG0793	Belongs to the peptidase S41A family
HPG46_24895	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_24900	COG2177	Part of the ABC transporter FtsEX involved in
HPG46_24905	COG2884	Cell division ATP-binding protein ftsE
HPG46_24925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPG46_24930	COG1278	Cold shock
HPG46_24935	COG1040	competence protein
HPG46_24940	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HPG46_24945	COG0791	NLP P60 protein
HPG46_24945	COG1388	LysM domain
HPG46_24950	COG1733	regulation of RNA biosynthetic process
HPG46_24955	COG1307	EDD domain protein, DegV family
HPG46_24960	COG1739	Uncharacterized protein family UPF0029
HPG46_24965	COG1316	TRANSCRIPTIONal
HPG46_24970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPG46_24975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPG46_24980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPG46_24990	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPG46_24990	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HPG46_25010	COG1486	melibiose metabolic process
HPG46_25015	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPG46_25020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_25030	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPG46_25040	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPG46_25050	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_25055	COG1301	dicarboxylic acid transport
HPG46_25065	COG0346	lactoylglutathione lyase activity
HPG46_25070	COG1511	domain protein
HPG46_25075	COG0583	DNA-binding transcription factor activity
HPG46_25080	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HPG46_25090	COG1271	oxidase subunit
HPG46_25095	COG1294	oxidase, subunit
HPG46_25100	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPG46_25135	COG1620	l-lactate permease
HPG46_25145	COG2389	metal-binding protein
HPG46_25155	COG1368	sulfuric ester hydrolase activity
HPG46_25165	COG0791	NLP P60 protein
HPG46_25165	COG1388	LysM domain
HPG46_25170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_25180	COG1215	transferase activity, transferring glycosyl groups
HPG46_25185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPG46_25190	COG3584	3D domain protein
HPG46_25190	COG1388	LysM domain
HPG46_25215	COG4715	Zinc finger, swim domain protein
HPG46_25220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPG46_25260	COG0577	efflux transmembrane transporter activity
HPG46_25265	COG1136	(ABC) transporter
HPG46_25285	COG2271	Major facilitator Superfamily
HPG46_25300	COG5002	protein histidine kinase activity
HPG46_25305	COG0745	RESPONSE REGULATOR receiver
HPG46_25310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPG46_25335	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPG46_25340	COG1134	teichoic acid transport
HPG46_25345	COG1682	transport, permease protein
HPG46_25350	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPG46_25370	COG1216	Glycosyl transferase, family 2
HPG46_25370	COG1442	glycosyl transferase family 8
HPG46_25390	COG1609	Transcriptional regulator
HPG46_25395	COG0726	polysaccharide deacetylase
HPG46_25405	COG0739	heme binding
HPG46_25420	COG3279	Response regulator of the LytR AlgR family
HPG46_25425	COG2385	sporulation resulting in formation of a cellular spore
HPG46_25440	COG4836	Membrane
HPG46_25445	COG1007	ATP synthesis coupled electron transport
HPG46_25450	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPG46_25455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPG46_25465	COG0839	Belongs to the complex I subunit 6 family
HPG46_25480	COG0649	NAD binding
HPG46_25485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPG46_25500	COG5001	Diguanylate cyclase
HPG46_25500	COG3300	MHYT domain
HPG46_25550	COG0356	it plays a direct role in the translocation of protons across the membrane
HPG46_25585	COG0698	ribose 5-phosphate isomerase
HPG46_25595	COG2190	(PTS) system
HPG46_25600	COG2259	Doxx family
HPG46_25605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPG46_25620	COG0009	L-threonylcarbamoyladenylate synthase
HPG46_25635	COG2890	protein-(glutamine-N5) methyltransferase activity
HPG46_25655	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPG46_25660	COG1494	fructose-1,6-bisphosphatase
HPG46_25680	COG4821	SIS domain
HPG46_25700	COG1960	acyl-CoA dehydrogenase activity
HPG46_25705	COG1960	acyl-CoA dehydrogenase activity
HPG46_25710	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPG46_25715	COG0183	Belongs to the thiolase family
HPG46_25720	COG0247	lactate metabolic process
HPG46_25720	COG2181	nitrate reductase activity
HPG46_25725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_25735	COG3300	MHYT domain
HPG46_25735	COG5001	Diguanylate cyclase
HPG46_25755	COG2197	response regulator
HPG46_25760	COG4585	Histidine kinase
HPG46_25765	COG0842	Transport permease protein
HPG46_25770	COG1131	(ABC) transporter
HPG46_25775	COG0024	Methionine aminopeptidase
HPG46_25785	COG2234	aminopeptidase activity
HPG46_25805	COG1595	DNA-templated transcription, initiation
HPG46_25815	COG4506	Protein conserved in bacteria
HPG46_25820	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPG46_25835	COG0010	Belongs to the arginase family
HPG46_25845	COG2814	Major facilitator Superfamily
HPG46_25850	COG0789	Transcriptional regulator
HPG46_25855	COG0584	glycerophosphoryl diester phosphodiesterase
HPG46_25860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_25870	COG1994	Peptidase M50
HPG46_25880	COG1078	dGTPase activity
HPG46_25885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_25890	COG1120	ATPase activity
HPG46_25895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_25900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_25920	COG0095	Lipoate-protein ligase
HPG46_25925	COG0280	phosphate acetyltransferase
HPG46_25940	COG3773	Cell wall hydrolase
HPG46_25950	COG2363	Small membrane protein
HPG46_25960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPG46_25965	COG2233	PERMEase
HPG46_25970	COG0561	phosphatase activity
HPG46_25975	COG2814	Major facilitator Superfamily
HPG46_25985	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPG46_25990	COG1131	(ABC) transporter
HPG46_25995	COG2755	lipolytic protein G-D-S-L family
HPG46_26000	COG1609	Transcriptional regulator
HPG46_26010	COG0460	homoserine dehydrogenase
HPG46_26020	COG2873	o-acetylhomoserine
HPG46_26030	COG1011	Hydrolase
HPG46_26035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPG46_26045	COG2197	response regulator
HPG46_26050	COG2203	Gaf domain
HPG46_26050	COG4585	Histidine kinase
HPG46_26055	COG0351	phosphomethylpyrimidine kinase
HPG46_26060	COG3706	GGDEF domain
HPG46_26065	COG2879	small protein
HPG46_26070	COG1966	Carbon starvation protein
HPG46_26075	COG3279	Response regulator of the LytR AlgR family
HPG46_26080	COG0477	Major facilitator Superfamily
HPG46_26105	COG0840	transmembrane signaling receptor activity
HPG46_26115	COG1607	acyl-coa hydrolase
HPG46_26130	COG0488	(ABC) transporter
HPG46_26150	COG0463	Glycosyl transferase, family 2
HPG46_26155	COG1309	transcriptional regulator
HPG46_26160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPG46_26165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPG46_26165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPG46_26170	COG0628	permease
HPG46_26185	COG3279	Response regulator of the LytR AlgR family
HPG46_26190	COG3275	phosphorelay sensor kinase activity
HPG46_26195	COG2814	Major facilitator Superfamily
HPG46_26200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPG46_26205	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HPG46_26210	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPG46_26230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPG46_26235	COG1272	protein, Hemolysin III
HPG46_26260	COG1164	Oligoendopeptidase f
HPG46_26280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPG46_26285	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HPG46_26290	COG4853	Protein conserved in bacteria
HPG46_26295	COG4863	YycH protein
HPG46_26300	COG5002	protein histidine kinase activity
HPG46_26305	COG0745	RESPONSE REGULATOR receiver
HPG46_26335	COG0305	Participates in initiation and elongation during chromosome replication
HPG46_26345	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HPG46_26350	COG4241	membrane
HPG46_26360	COG0629	single-stranded DNA binding
HPG46_26370	COG0012	GTP binding
HPG46_26375	COG4481	Protein conserved in bacteria
HPG46_26380	COG0668	transmembrane transport
HPG46_26390	COG1475	DNA binding
HPG46_26395	COG1192	Involved in chromosome partitioning
HPG46_26420	COG1847	R3H domain protein
HPG46_26425	COG0706	membrane insertase activity
HPG46_26435	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPG46_26445	COG0592	DNA-directed DNA polymerase activity
HPG46_26450	COG2501	S4 domain
HPG46_26460	COG0187	DNA topoisomerase II activity
HPG46_26465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPG46_26500	COG0516	GMP reductase activity
HPG46_26500	COG0517	IMP dehydrogenase activity
HPG46_26505	COG1686	Belongs to the peptidase S11 family
HPG46_26535	COG1428	Deoxynucleoside kinase
HPG46_26540	COG1428	Deoxynucleoside kinase
HPG46_26545	COG1335	isochorismatase
HPG46_26550	COG0590	tRNA wobble adenosine to inosine editing
HPG46_26560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPG46_26615	COG1982	Orn Lys Arg decarboxylase major
HPG46_26625	COG0470	DNA polymerase III
HPG46_26630	COG1774	PSP1 C-terminal conserved region
HPG46_26640	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HPG46_26650	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPG46_26655	COG2002	toxin-antitoxin pair type II binding
HPG46_26660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPG46_26660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPG46_26665	COG0084	hydrolase, TatD family'
HPG46_26670	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HPG46_26685	COG4466	Protein conserved in bacteria
HPG46_26700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPG46_26705	COG0251	oxidation-reduction process
HPG46_26735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPG46_26740	COG2002	toxin-antitoxin pair type II binding
HPG46_26745	COG2244	polysaccharide biosynthetic process
HPG46_26750	COG3956	TIGRFAM MazG family protein
HPG46_26755	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPG46_26775	COG1098	S1 RNA binding domain
HPG46_26790	COG2208	phosphoserine phosphatase activity
HPG46_26800	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HPG46_26805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPG46_26820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPG46_26825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPG46_26830	COG0512	Glutamine amidotransferase of anthranilate synthase
HPG46_26835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPG46_26840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPG46_26845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPG46_26850	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPG46_26855	COG1396	sequence-specific DNA binding
HPG46_26860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPG46_26905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_26940	COG2312	Erythromycin esterase
HPG46_26950	COG1396	sequence-specific DNA binding
HPG46_26970	COG0840	transmembrane signaling receptor activity
HPG46_26990	COG5183	chlorophyll binding
HPG46_26990	COG2133	pyrroloquinoline quinone binding
HPG46_27015	COG2184	nucleotidyltransferase activity
HPG46_27020	COG1760	l-serine dehydratase
HPG46_27025	COG1760	l-serine dehydratase
HPG46_27030	COG0814	amino acid
HPG46_27045	COG1309	transcriptional regulator
HPG46_27050	COG2814	Major facilitator Superfamily
HPG46_27055	COG2184	nucleotidyltransferase activity
HPG46_27065	COG0534	Mate efflux family protein
HPG46_27080	COG0531	amino acid
HPG46_27110	COG2304	oxidoreductase activity
HPG46_27120	COG1404	Belongs to the peptidase S8 family
HPG46_27135	COG4974	Belongs to the 'phage' integrase family
HPG46_27145	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HPG46_27150	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPG46_27155	COG2017	converts alpha-aldose to the beta-anomer
HPG46_27165	COG2207	Transcriptional regulator
HPG46_27170	COG1266	CAAX protease self-immunity
HPG46_27180	COG5492	domain, Protein
HPG46_27190	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HPG46_27195	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPG46_27195	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_27200	COG3716	PTS system mannose fructose sorbose family IID component
HPG46_27205	COG3715	PTS system
HPG46_27215	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_27220	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HPG46_27225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPG46_27235	COG1414	Transcriptional regulator
HPG46_27245	COG0457	Tetratricopeptide repeat
HPG46_27290	COG0546	phosphoglycolate phosphatase activity
HPG46_27295	COG1475	DNA binding
HPG46_27300	COG0737	Belongs to the 5'-nucleotidase family
HPG46_27325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPG46_27350	COG2211	Major facilitator Superfamily
HPG46_27375	COG2205	protein histidine kinase activity
HPG46_27380	COG0745	RESPONSE REGULATOR receiver
HPG46_27410	COG2814	Major facilitator Superfamily
HPG46_27440	COG3443	Belongs to the bacterial solute-binding protein 9 family
HPG46_27450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_27455	COG1923	regulation of RNA biosynthetic process
HPG46_27540	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPG46_27555	COG1404	Belongs to the peptidase S8 family
HPG46_27610	COG0667	Aldo Keto reductase
HPG46_27625	COG1396	sequence-specific DNA binding
HPG46_27630	COG0582	viral genome integration into host DNA
HPG46_27735	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPG46_27890	COG1404	Belongs to the peptidase S8 family
HPG46_27895	COG2197	response regulator
HPG46_27900	COG4585	Histidine kinase
HPG46_27980	COG0739	heme binding
HPG46_27980	COG0741	lytic transglycosylase activity
HPG46_27980	COG1196	nuclear chromosome segregation
HPG46_28020	COG2234	aminopeptidase activity
HPG46_28110	COG2373	Large extracellular alpha-helical protein
HPG46_28120	COG3397	chitin binding
HPG46_28185	COG1404	Belongs to the peptidase S8 family
HPG46_28275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPG46_28370	COG4962	Type ii secretion system protein e
HPG46_28600	COG0739	heme binding
HPG46_28605	COG3227	Zinc metalloprotease (Elastase)
HPG46_28625	COG1073	alpha beta
HPG46_28630	COG2311	Membrane
HPG46_28715	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_28740	COG2814	Major facilitator Superfamily
HPG46_28770	COG0577	efflux transmembrane transporter activity
HPG46_28775	COG1136	(ABC) transporter
HPG46_28800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_28810	COG1309	transcriptional regulator
HPG46_28820	COG4221	oxidoreductase activity
HPG46_28830	COG2309	aminopeptidase activity
HPG46_28845	COG0456	acetyltransferase
HPG46_28870	COG1395	domain, Protein
HPG46_28880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins